Mercurial > repos > iuc > hamronize_tool

changeset 1:ec82fac4eb4b draft

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"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hamronization commit b872ea086ebd98be64839e7bbb1ddf7a181943d0"
author iuc
date Sat, 23 Oct 2021 21:38:09 +0000
parents d2590ecc4189
children 41c7e03b3eab
files hamronize_tool.xml macros.xml test-data/rgi/rgi.json test-data/summary.json
diffstat 4 files changed, 13 insertions(+), 15 deletions(-) [+]
line wrap: on
line diff
--- a/hamronize_tool.xml	Tue Mar 16 12:38:42 2021 +0000
+++ b/hamronize_tool.xml	Sat Oct 23 21:38:09 2021 +0000
@@ -1,9 +1,8 @@
-<tool id="hamronize_tool" name="hamronize" version="@VERSION@+galaxy0">
+<tool id="hamronize_tool" name="hamronize" version="@TOOL_VERSION@+galaxy1" profile="@PROFILE@">
     <description> parse multiple Antimicrobial Resistance Analysis Reports into a common data structure</description>
     <macros>
         <import>macros.xml</import>
     </macros>
-
     <expand macro="requirements" />
     <expand macro="version_command" />
 
@@ -34,7 +33,7 @@
     ]]>    </command>
 
     <inputs>
-        <param name="report" type="data" format="txt,tabular,tsv" label="Report file"/>
+        <param name="report" type="data" format="txt,tabular" label="Report file"/>
         <conditional name="select_tool">
             <param name="tool" type="select" label="Tool">
                 <option value="abricate" selected="true">abricate</option>
@@ -117,7 +116,7 @@
     </inputs>
 
     <outputs>
-        <data format="tsv" name="output_tsv" label="${tool.name} on ${on_string}: Output" from_work_dir="hamronized.tsv">
+        <data format="tabular" name="output_tsv" label="${tool.name} on ${on_string}: Output" from_work_dir="hamronized.tsv">
             <filter>output_format == "tsv"</filter>
         </data>
         <data format="json" name="output_json" label="${tool.name} on ${on_string}: Output" from_work_dir="hamronized.json">
@@ -127,31 +126,31 @@
     <tests>
         <!-- abricate -->
         <test expect_num_outputs="1">
-            <param name="report" value="abricate/report.tsv" ftype="tsv" />
+            <param name="report" value="abricate/report.tsv" ftype="tabular" />
             <param name="tool" value="abricate" />
             <param name="output_format" value="tsv" />
             <param name="reference_database_version" value="db_v_1" />
             <param name="analysis_software_version" value="tool_v_1" />
-            <output name="output_tsv" ftype="tsv" file="hamronized_abricate.tsv" />
+            <output name="output_tsv" file="hamronized_abricate.tsv" ftype="tabular" />
         </test>
         <test expect_num_outputs="1">
-            <param name="report" value="abricate/report.tsv" ftype="tsv" />
+            <param name="report" value="abricate/report.tsv" ftype="tabular" />
             <param name="tool" value="abricate" />
             <param name="output_format" value="json" />
             <param name="reference_database_version" value="db_v_1" />
             <param name="analysis_software_version" value="tool_v_1" />
-            <output name="output_json" ftype="json" file="hamronized_abricate.json" />
+            <output name="output_json" file="hamronized_abricate.json" ftype="json" />
         </test>
         <!-- ariba -->
         <test expect_num_outputs="1">
-            <param name="report" value="ariba/report.tsv" ftype="tsv" />
+            <param name="report" value="ariba/report.tsv" ftype="tabular" />
             <param name="tool" value="ariba" />
             <param name="output_format" value="tsv" />
             <param name="reference_database_version" value="db_v_1" />
             <param name="analysis_software_version" value="ariba_v1" />
             <param name="input_file_name" value="ariba_report" />
             <param name="reference_database_id" value="dbname" />
-            <output name="output_tsv" ftype="tsv" file="hamronized_ariba.tsv" />
+            <output name="output_tsv" file="hamronized_ariba.tsv" ftype="tabular" />
         </test>
         <!-- rgi -->
         <test expect_num_outputs="1">
@@ -161,7 +160,7 @@
             <param name="reference_database_version" value="card_v1" />
             <param name="analysis_software_version" value="rgi_v1" />
             <param name="input_file_name" value="rgi_report" />
-            <output name="output_tsv" ftype="tsv" file="hamronized_rgi.tsv" />
+            <output name="output_tsv" file="hamronized_rgi.tsv" ftype="tabular"/>
         </test>
     </tests>
     <help><![CDATA[
--- a/macros.xml	Tue Mar 16 12:38:42 2021 +0000
+++ b/macros.xml	Sat Oct 23 21:38:09 2021 +0000
@@ -1,9 +1,10 @@
 <macros>
-    <token name="@VERSION@">1.0.3</token>
+    <token name="@TOOL_VERSION@">1.0.3</token>
+    <token name="@PROFILE@">20.05</token>
     
     <xml name="requirements">
         <requirements>
-            <requirement type="package" version="@VERSION@">hamronization</requirement>
+            <requirement type="package" version="@TOOL_VERSION@">hamronization</requirement>
         </requirements>
     </xml>
     
--- a/test-data/rgi/rgi.json	Tue Mar 16 12:38:42 2021 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,1 +0,0 @@
-{"NODE_1_length_803036_cov_42.265_33 # 30758 # 31933 # 1 # ID=1_33;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.599": {"gnl|BL_ORD_ID|2216|hsp_num:0": {"type_match": "Perfect", "model_id": "2399", "orf_strand": "+", "orf_start": 30758, "orf_end": 31933, "orf_from": "NODE_1_length_803036_cov_42.265_33", "model_name": "oqxA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "670", "ARO_accession": "3003922", "ARO_name": "oqxA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35992": {"category_aro_accession": "0000075", "category_aro_cvterm_id": "35992", "category_aro_name": "nitrofurantoin", "category_aro_description": "Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "41240": {"category_aro_accession": "3004116", "category_aro_cvterm_id": "41240", "category_aro_name": "nitrofuran antibiotic", "category_aro_description": "Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 798.119, "max_identities": 391, "cvterm_id": "35914", "query": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "match": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "sequence_from_db": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "sequence_from_broadstreet": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "dna_sequence_from_broadstreet": "ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCACAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACTGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTCGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAAAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTGGGCGAGGAGGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACGCCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCAGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACCGTTGCCATGACCTCCAGCGCCACCCTTAACTGA", "partial": "0", "query_start": 30758, "query_end": 31930, "orf_dna_sequence": "ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCGCAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACCGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTGGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAGAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTTGGCGAGGAAGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACACCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCTGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACTGTTGCCATGACCTCCAGCGCCACCCTTAACTGA", "orf_prot_sequence": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "perc_identity": 100.0}}, "NODE_1_length_803036_cov_42.265_34 # 31957 # 35109 # 1 # ID=1_34;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.612": {"gnl|BL_ORD_ID|2217|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 31957, "orf_end": 35109, "orf_from": "NODE_1_length_803036_cov_42.265_34", "model_name": "oqxB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2400", "pass_evalue": "n/a", "pass_bitscore": "2000", "ARO_accession": "3003923", "ARO_name": "oqxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35992": {"category_aro_accession": "0000075", "category_aro_cvterm_id": "35992", "category_aro_name": "nitrofurantoin", "category_aro_description": "Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "41240": {"category_aro_accession": "3004116", "category_aro_cvterm_id": "41240", "category_aro_name": "nitrofuran antibiotic", "category_aro_description": "Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 2107.8, "max_identities": 1045, "cvterm_id": "35914", "query": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLLA", "match": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSP GKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLV KTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLT+LFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGP+RESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDL A", "sequence_from_db": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPGGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVGKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTDLFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPYRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLPA", "sequence_from_broadstreet": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPGGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVGKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTDLFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPYRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLPA", "dna_sequence_from_broadstreet": "ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTCTCCCCCGGCGGGAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCTGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGTTGATCGCTGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGCCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGACTGGTAGGCAAAACGCTTGGACGCCGTGGCGCAGTGTTTGCGGTGTACCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATCAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTTTCCATCCTGCCGCCGCCGATTTTAGGTCTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGATCTGTTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCTGACGGACCATACCGCGAGAGCGTGGAAGATATCGCCAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTACCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAAGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCATTCCTCGTACTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCATGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTGTTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTACGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCCCGCCTAG", "partial": "0", "query_start": 31957, "query_end": 35106, "orf_dna_sequence": "ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTTTCGCCAAACGGTAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCGGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGCTGATCGCGGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGTCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGGCTGGTGAGCAAAACCCTCGGACGCCGTGGCGCGGTGTTTGCGGTGTATCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATTAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTCTCCATCCTGCCGCCGCCGATTTTAGGACTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGAGCTATTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCCGATGGGCCATTCCGCGAGAGCGTGGAAGATATTGCTAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTGCCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAGGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCGTTCCTCGTGCTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCGTGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTATTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTGCGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCTCGCCTAG", "orf_prot_sequence": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLLA", "perc_identity": 99.52}, "gnl|BL_ORD_ID|137|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 31957, "orf_end": 35109, "orf_from": "NODE_1_length_803036_cov_42.265_34", "model_name": "adeF", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "153", "pass_evalue": "n/a", "pass_bitscore": "750", "ARO_accession": "3000777", "ARO_name": "adeF", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1208.74, "max_identities": 639, "cvterm_id": "35535", "query": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKH---TAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRK", "match": "M+ S+FFIDRPIFA VLS+LI + GL+++  LP+SEYP+VVPPSV VRA+YPGANPKVIAETVA+PLEE+INGVE+M+YM+S A SDG L  TV F+ G DPD+AQ  VQNRV+QA  RLPEDV+RLG+TT K SPTLT+VVHL SP+ +YD  Y+RNYA L VKD LARL GVG++ +FGSG+YAMRVWLDP KVA R LTA+++V A++EQN+QV+AG +GA P    S   +S+NAQGRL TE+EF +IILKTA DG++ RL DVAR+E+ +  Y LRS L+NK AV I IFQ+PGANA+ +S+ VR+ M EL+  FP  +++   YDPT FVR SI+AVV TLLEA+ LVV+VVILFLQTWRASIIPL+AVPVS++GTF+++   G+S+N LSLFG+VLAIGIVVDDAIVVVENVERNIE GL P  A ++AMREVSGPIIAIAL L AVFVP+AF++G+TGQFYKQFA+TIAISTVISA NSLTLSPALAALLLK H AK D  TR+++R+FG  F  FNR F R+S+ Y   VS+ +  + +   VY  LL     +  +VPGGF+P QDK YLI   ++P G+SL RT+AVIRKMS+  +   GV+ AVAFPGL+   FTN+ + G VF  LKPFD+RK    +A  I   +N K + IQ  +     PPP++GLG   G+ L ++DRG LGY AL  A      A    P +    S+YQ NVPQL+V +DR KAK QGV++T++F T+Q YLGS YVNDFN+FGR ++V AQAD PFR + EDI  L+TRN+ G+MVP+ S+VN++ TYGP+ V+RYNGY +AD+ G   P   SSSQA   +E ++ Q LP G+  EWTDL++Q+   GN  L VFP++VLL FLVLAA YES TLPLAVILIVPM +L+AL GVWLT GDNN+F Q+GL+VL+GLACKNAILIVEFARELE+QG    +AA+EA RLRLRPI+MTSIAFI G +PL+   GAG+E+R   G+ VF GM+GVT FGLFLTP FYV +R L ++ K", "sequence_from_db": "MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASP--SNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPG-YSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHK", "sequence_from_broadstreet": "MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPSNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHKLHSAAVHEAPLASPHDH", "dna_sequence_from_broadstreet": "ATGAATATTTCTAAATTTTTTATTGATCGGCCGATCTTTGCTGGTGTGCTATCAGTCTTGATTTTACTCGCCGGTCTCCTTTCGGTATTTCAGTTACCGATTTCTGAATATCCCGAGGTTGTTCCACCATCTGTGGTGGTACGCGCCCAATATCCGGGTGCAAACCCAAAAGTGATTGCTGAAACGGTTGCATCTCCGCTCGAAGAGTCAATCAACGGCGTCGAAGACATGCTGTATATGCAATCTCAAGCAAACAGCGACGGTAACCTAACCATTACGGTGAACTTTAAGCTCGGTATCGACCCAGACAAAGCCCAACAATTGGTTCAAAACCGTGTGTCTCAGGCCATGCCCCGTTTACCTGAAGATGTACAGCGCTTAGGTGTAACCACACTAAAAAGCTCACCTACTTTAACTATGGTAGTGCATCTGACCTCACCAGATAATCGCTATGACATGACCTACTTACGTAACTATGCGGTGCTCAACGTGAAAGACCGTTTAGCGCGTTTACAAGGGGTTGGTGAAGTCGGATTATTTGGTTCTGGTGACTACGCGATGCGTGTATGGCTTGACCCGCAAAAAGTAGCGCAGCGTAACCTCACCGCGACCGAAATTGTGAATGCAATCCGTGAACAAAATATTCAGGTTGCAGCGGGTACAATCGGTGCATCACCAAGTAATTCACCTTTACAGCTTTCAGTCAATGCTCAAGGTCGTTTAACTACTGAACAAGAATTCGCAGATATCATTTTAAAAACTGCACCAGATGGCGCGGTTACCCGATTGGGTGATGTTGCTCGTGTCGAACTTGCAGCCTCTCAATATGGCTTACGTTCATTGCTTGATAATAAACAAGCGGTCGCGATTCCAATTTTCCAAGCACCGGGTGCGAATGCTTTACAAGTTTCCGATCAAGTGCGTAGCACAATGAAGGAGCTTTCAAAAGATTTCCCATCTTCAATTAAATACGACATTGTTTATGACCCGACTCAATTCGTACGTGCAAGTATTAAAGCGGTCGTTCATACCTTACTTGAAGCAATTACACTGGTTGTTGTGGTCGTTATTTTATTCTTGCAAACATGGCGTGCCTCAATCATTCCATTGCTTGCCGTACCGGTTTCAATTATTGGTACATTCGCGCTCATGCTCGCTTTTGGTTACTCAATCAATGCGCTATCACTGTTCGGAATGGTACTTGCCATCGGGATTGTCGTCGATGACGCGATTGTGGTCGTCGAAAATGTCGAGAGGAATATTGAAGCAGGCTTAAACCCAAGGGAGGCGACTTACCGTGCCATGCGAGAAGTCAGTGGACCGATTATTGCCATTGCTTTAACACTTGTTGCAGTATTCGTACCTCTTGCCTTTATGACAGGCTTAACAGGGCAATTCTATAAACAATTTGCCATGACCATTGCCATTTCAACGGTTATTTCGGCATTTAACTCGCTTACCCTATCTCCTGCTTTGGCAGCGCTGTTACTGAAAGGACATGATGCTAAACCGGATGCCTTAACACGTATTATGAATCGTGTATTCGGTCGTTTCTTTGCACTGTTTAACCGTGTGTTTTCACGTGCTTCAGACCGTTATAGTCAAGGCGTCAGCCGTGTCATTTCCCATAAAGCTTCGGCAATGGGTGTCTATGCAGCACTCTTAGGTTTAACCGTTGGTATTTCCTATATTGTTCCAGGTGGTTTCGTTCCTGCGCAGGACAAACAATATTTAATTAGCTTTGCGCAGCTACCAAACGGCGCATCATTAGATCGTACCGAAGCGGTCATTCGTAAAATGAGTGACACTGCACTTAAACAACCTGGTGTAGAAAGTGCAGTTGCCTTTCCTGGCCTATCAATTAACGGTTTCACCAATAGCTCAAGTGCCGGTATTGTCTTTGTGACTTTAAAGCCATTTGATGAACGTAAGGCAAAAGACTTATCTGCAAATGCAATTGCAGGTGCGCTCAACCAGAAATATTCAGCTATTCAAGATGCCTATATCGCGGTTTTCCCACCGCCACCAGTGATGGGCTTAGGTACTATGGGCGGCTTTAAACTACAACTTGAAGACCGAGGTGCCTTAGGCTATTCAGCCTTGAACGATGCTGCACAAAACTTTATGAAGGCAGCACAATCAGCCCCTGAACTGGGTCCAATGTTCTCAAGTTATCAAATTAACGTACCTCAACTCAACGTAGATCTGGACCGTGTAAAAGCTAAACAGCAAGGCGTTGCTGTGACAGATGTTTTCAATACTATGCAGATTTATTTAGGTTCTCAGTACGTTAACGACTTTAACCGCTTTGGACGTGTTTATCAGGTTCGTGCACAAGCCGATGCGCCTTTCCGTGCTAACCCTGAAGATATTTTGCAGCTTAAAACCCGTAATAGTGCCGGACAAATGGTGCCATTATCTTCATTGGTGAATGTAACTCAAACCTATGGTCCTGAAATGGTCGTTCGTTATAACGGTTACACATCAGCAGATATTAACGGTGGCCCTGCCCCAGGTTATTCATCTAGCCAAGCAGAAGCTGCGGTTGAACGTATTGCTGCACAAACTCTACCGCGTGGTATCAAGTTTGAATGGACAGATTTAACTTATCAAAAAATCTTGGCTGGTAATGCTGGACTTTGGGTATTCCCTATTAGCGTATTACTCGTGTTCTTAGTGTTAGCTGCTCAGTATGAAAGCTTAACCCTACCATTAGCAGTTATCTTAATTGTACCAATGGGAATCTTAGCGGCTCTGACAGGTGTCTGGTTGACAGCTGGAGATAACAACATCTTTACTCAAATCGGTCTAATGGTACTGGTCGGGCTAGCCTGTAAAAATGCCATCTTAATTGTCGAATTTGCGAGGGAACTTGAAATGCAAGGTGCGACTGCCTTTAAAGCAGCCGTTGAAGCAAGTCGTCTACGTTTACGCCCAATTTTAATGACCTCTATTGCATTTATTATGGGTGTAGTGCCACTGGTTACTTCAACTGGCGCAGGTTCTGAAATGCGACATGCGATGGGTGTTGCCGTATTCTTCGGTATGATCGGTGTAACATTCTTTGGTTTATTCCTCACCCCGGCCTTTTACGTTCTGATTCGTACCCTCAACAGCAAACATAAACTGCATTCTGCGGCAGTTCATGAAGCGCCGTTAGCTAGCCCACATGATCATTAA", "partial": "0", "query_start": 31957, "query_end": 35082, "orf_dna_sequence": "ATGGACTTTTCCCGCTTTTTTATCGACAGGCCGATTTTCGCCGCGGTGCTGTCGATTTTAATTTTTATCACCGGGTTAATCGCTATCCCACTGCTGCCGGTGAGCGAATATCCGGATGTCGTCCCGCCGAGCGTCCAGGTGCGCGCGGAGTATCCCGGCGCCAACCCGAAAGTGATTGCCGAGACCGTGGCGACGCCGCTGGAGGAAGCGATCAACGGCGTTGAAAACATGATGTACATGAAATCGGTCGCCGGCTCCGACGGCGTGCTGGTCACCACCGTCACCTTCCGCCCGGGTACCGACCCGGATCAGGCGCAGGTTCAGGTGCAGAACCGCGTCGCGCAGGCCGAAGCGCGTCTGCCGGAGGATGTACGCCGTCTGGGGATCACCACCCAGAAGCAGTCTCCGACGCTGACCCTGGTGGTGCATCTGTTTTCGCCAAACGGTAAGTACGACTCGCTGTATATGCGCAACTACGCCACGCTGAAAGTGAAGGATGAGCTGGCGCGCCTGCCCGGCGTCGGCCAGATCCAGATTTTTGGCTCCGGTGAATATGCGATGCGCGTCTGGCTGGATCCCAATAAGGTCGCGGCCCGCGGTCTGACGGCCTCGGATGTGGTGACGGCGATGCAGGAGCAAAACGTCCAGGTGTCTGCCGGACAGCTTGGCGCCGAGCCGCTGCCGCAGGAGAGCGATTTCCTGATCTCCATTAACGCCCAGGGCCGTCTGCATACCGAAGAAGAGTTTGGCAATATCATTCTGAAAACGGCGCAGGATGGCTCGCTGGTCCGCCTGCGCGACGTGGCGCGCATCGAGATGGGTTCCGGTAGCTATGCGCTGCGCTCCCAGCTCAACAATAAGGATGCGGTCGGGATCGGTATCTTCCAGTCACCCGGCGCTAACGCCATCGATCTGTCGAACGCGGTACGCGCCAAAATGGCCGAGCTGGCCACCCGCTTCCCGGAAGATATGCAATGGGCGGCGCCGTACGACCCGACGGTTTTCGTCCGCGACTCCATCCGCGCGGTGGTGCAGACGCTGCTGGAGGCGGTAGTGCTGGTGGTGCTGGTAGTGATCCTGTTCCTGCAGACCTGGCGCGCGTCGATTATCCCGCTGATCGCGGTGCCGGTATCGGTGGTGGGTACCTTCAGCATTCTCTATCTGCTGGGCTTCTCGCTGAATACCCTGAGCCTGTTCGGGCTGGTACTGGCTATCGGTATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAGCGTAATATCGAAGAGGGGCTTGCGCCGCTTGCCGCGGCGCATCAGGCGATGCGTGAGGTCTCCGGGCCGATTATCGCCATTGCGCTGGTGCTGTGTGCGGTGTTCGTGCCGATGGCGTTTCTCTCCGGGGTCACCGGCCAGTTCTACAAACAGTTCGCGGTGACCATCGCCATCTCGACGGTGATCTCGGCCATCAACTCGCTGACGCTCTCCCCGGCGCTGGCGGCCCTGCTGTTAAAGCCGCACGGCGCGAAGAAAGACCTCCCTACCCGGCTGATCGATCGTCTGTTTGGCTGGATTTTCCGTCCGTTTAACCGCTTTTTCCTGCGCAGCTCGAACGGCTATCAGGGGCTGGTGAGCAAAACCCTCGGACGCCGTGGCGCGGTGTTTGCGGTGTATCTGCTGCTGCTCTGCGCCGCTGGGGTGATGTTTAAAGTCGTCCCCGGCGGGTTTATTCCCACCCAGGATAAGCTGTATCTCATTGGCGGCGTGAAGATGCCGGAAGGGTCGTCGCTGGCGCGCACCGACGCGGTGATCCGCAAAATGAGCGAGATCGGGATGAATACCGAAGGGGTCGACTATGCGGTCGCTTTCCCGGGGCTTAACGCGCTGCAGTTCACCAACACGCCGAATACCGGGACGGTCTTTTTTGGCCTGAAACCGTTCGACCAGCGCAAACACACGGCGGCGGAAATTAACGCGGAGATTAACGCCAAAATCGCGCAAATCCAGCAGGGCTTTGGCTTCTCCATCCTGCCGCCGCCGATTTTAGGACTGGGTCAGGGTTCCGGCTACTCCCTGTACATCCAGGATCGCGGAGGGCTGGGCTATGGCGCGCTGCAAAGCGCGGTGAATGCGATGTCCGGGGCGATTATGCAGACGCCGGGGATGCACTTCCCGATCTCGACTTACCAGGCTAACGTGCCGCAGCTGGACGTGCAGGTCGATCGCGATAAGGCGAAAGCGCAGGGGGTATCGCTAACCGAGCTATTCGGTACGCTGCAGACCTATCTCGGCTCGTCTTATGTCAATGACTTTAACCAGTTCGGGCGTACCTGGCGCGTGATGGCCCAGGCCGATGGGCCATTCCGCGAGAGCGTGGAAGATATTGCTAATCTGCGCACCCGCAATAATCAGGGCGAAATGGTGCCGATCGGCAGTATGGTGAATATCAGTACCACCTACGGGCCGGATCCGGTGATCCGCTACAACGGTTATCCGGCGGCGGACCTGATTGGCGATGCCGATCCGCGGGTCCTCTCTTCTTCGCAGGCGATGACGCATCTGGAGGAGCTGTCGAAGCAGATCCTGCCGAATGGGATGAATATTGAGTGGACGGATCTCAGCTTCCAGCAGGCCACCCAGGGCAACACGGCGCTGATCGTCTTCCCGGTGGCGGTGCTGCTGGCGTTCCTCGTGCTGGCCGCGCTGTATGAAAGCTGGACCCTGCCGCTGGCGGTGATCCTTATCGTACCGATGACGATGCTCTCCGCGCTGTTTGGCGTCTGGCTGACCGGGGGCGATAACAACGTCTTCGTGCAGGTGGGTCTGGTGGTCCTGATGGGCCTGGCCTGTAAAAACGCCATTCTGATCGTCGAGTTTGCCCGCGAGCTGGAGATCCAGGGGAAAGGCATCATGGAAGCGGCGCTGGAGGCGTGCCGCCTGCGTCTGCGCCCGATCGTGATGACCTCCATCGCCTTTATCGCCGGGACCATTCCGCTGATCCTCGGCCACGGCGCGGGGGCGGAAGTCCGCGGCGTCACCGGGATCACGGTATTCTCCGGGATGCTGGGCGTGACGCTCTTCGGTCTGTTCCTGACGCCGGTGTTTTACGTGACGCTGCGGAAACTGGTGACCCGCAGGAAGCCGGTCCAGGAGGATCTGCTCGCCTAG", "orf_prot_sequence": "MDFSRFFIDRPIFAAVLSILIFITGLIAIPLLPVSEYPDVVPPSVQVRAEYPGANPKVIAETVATPLEEAINGVENMMYMKSVAGSDGVLVTTVTFRPGTDPDQAQVQVQNRVAQAEARLPEDVRRLGITTQKQSPTLTLVVHLFSPNGKYDSLYMRNYATLKVKDELARLPGVGQIQIFGSGEYAMRVWLDPNKVAARGLTASDVVTAMQEQNVQVSAGQLGAEPLPQESDFLISINAQGRLHTEEEFGNIILKTAQDGSLVRLRDVARIEMGSGSYALRSQLNNKDAVGIGIFQSPGANAIDLSNAVRAKMAELATRFPEDMQWAAPYDPTVFVRDSIRAVVQTLLEAVVLVVLVVILFLQTWRASIIPLIAVPVSVVGTFSILYLLGFSLNTLSLFGLVLAIGIVVDDAIVVVENVERNIEEGLAPLAAAHQAMREVSGPIIAIALVLCAVFVPMAFLSGVTGQFYKQFAVTIAISTVISAINSLTLSPALAALLLKPHGAKKDLPTRLIDRLFGWIFRPFNRFFLRSSNGYQGLVSKTLGRRGAVFAVYLLLLCAAGVMFKVVPGGFIPTQDKLYLIGGVKMPEGSSLARTDAVIRKMSEIGMNTEGVDYAVAFPGLNALQFTNTPNTGTVFFGLKPFDQRKHTAAEINAEINAKIAQIQQGFGFSILPPPILGLGQGSGYSLYIQDRGGLGYGALQSAVNAMSGAIMQTPGMHFPISTYQANVPQLDVQVDRDKAKAQGVSLTELFGTLQTYLGSSYVNDFNQFGRTWRVMAQADGPFRESVEDIANLRTRNNQGEMVPIGSMVNISTTYGPDPVIRYNGYPAADLIGDADPRVLSSSQAMTHLEELSKQILPNGMNIEWTDLSFQQATQGNTALIVFPVAVLLAFLVLAALYESWTLPLAVILIVPMTMLSALFGVWLTGGDNNVFVQVGLVVLMGLACKNAILIVEFARELEIQGKGIMEAALEACRLRLRPIVMTSIAFIAGTIPLILGHGAGAEVRGVTGITVFSGMLGVTLFGLFLTPVFYVTLRKLVTRRKPVQEDLLA", "perc_identity": 61.15}}, "NODE_1_length_803036_cov_42.265_80 # 79380 # 79910 # 1 # ID=1_80;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.520": {"gnl|BL_ORD_ID|1251|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 79380, "orf_end": 79910, "orf_from": "NODE_1_length_803036_cov_42.265_80", "model_name": "emrR", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1330", "pass_evalue": "n/a", "pass_bitscore": "280", "ARO_accession": "3000516", "ARO_name": "emrR", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.09906e-122, "bit_score": 338.961, "max_identities": 162, "cvterm_id": "36849", "query": "MDSSFTPIEQMLKFRASRHEDFPFQEILLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHQFLREVLPPQHNCLHQLWSSLSTSEKDQLEHITRKLLSRLDQMEEEGVLADSL", "match": "MDSSFTPIEQMLKFRASRHEDFP+QEILLTRLCMHMQ KLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGH+FLREVLPPQHNCLHQLWS+LST+EKDQLE ITRKLLSRLDQME++GV+ +++", "sequence_from_db": "MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAM", "sequence_from_broadstreet": "MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS", "dna_sequence_from_broadstreet": "ATGGATAGTTCGTTTACGCCCATTGAACAAATGCTAAAATTTCGCGCCAGCCGCCACGAAGATTTTCCTTATCAGGAGATCCTTCTGACTCGTCTTTGCATGCACATGCAAAGCAAGCTGCTGGAGAACCGCAATAAAATGCTGAAGGCTCAGGGGATTAACGAGACGTTGTTTATGGCGTTGATTACGCTGGAGTCTCAGGAAAACCACAGTATTCAGCCTTCTGAATTAAGTTGTGCTCTTGGATCATCCCGTACCAACGCGACGCGTATTGCCGATGAACTGGAAAAACGCGGTTGGATCGAACGTCGTGAAAGCGATAACGATCGCCGCTGCCTGCATCTGCAATTAACGGAAAAAGGTCACGAGTTTTTGCGCGAGGTTTTACCACCGCAGCATAACTGCCTGCATCAACTCTGGTCCGCGCTCAGCACAACAGAAAAAGATCAGCTCGAGCAAATCACCCGCAAATTGCTCTCCCGTCTCGACCAGATGGAACAAGACGGTGTGGTTCTCGAAGCGATGAGCTAA", "partial": "0", "query_start": 79380, "query_end": 79904, "orf_dna_sequence": "ATGGATAGTTCGTTTACTCCCATTGAGCAAATGCTCAAGTTCCGCGCCAGCCGCCATGAAGATTTCCCGTTTCAGGAGATCCTGTTAACTCGTCTTTGCATGCATATGCAAGGTAAGCTGCTGGAAAATCGCAATAAAATGCTCAAAGCGCAGGGAATTAACGAGACATTATTTATGGCGCTGATTACGCTGGAGTCACAGGAAAACCACAGCATCCAGCCGTCCGAGCTGAGCTGTGCGCTGGGCTCGTCACGTACCAACGCCACCCGTATCGCTGATGAACTGGAAAAACGCGGCTGGATTGAGCGCCGCGAGAGCGATAACGATCGTCGCTGTTTGCATCTGCAACTGACCGAAAAGGGCCATCAGTTTTTGCGTGAAGTCCTGCCGCCGCAGCATAACTGCCTGCATCAGCTGTGGTCTTCACTTAGCACCAGCGAAAAAGATCAGCTCGAACACATCACCCGCAAACTCCTGAGCCGCCTTGATCAGATGGAAGAAGAAGGCGTGCTAGCGGACTCTCTACGCTAA", "orf_prot_sequence": "MDSSFTPIEQMLKFRASRHEDFPFQEILLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHQFLREVLPPQHNCLHQLWSSLSTSEKDQLEHITRKLLSRLDQMEEEGVLADSLR", "perc_identity": 92.57}}, "NODE_1_length_803036_cov_42.265_81 # 80036 # 81208 # 1 # ID=1_81;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.594": {"gnl|BL_ORD_ID|2786|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 80036, "orf_end": 81208, "orf_from": "NODE_1_length_803036_cov_42.265_81", "model_name": "Klebsiella pneumoniae KpnG", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3298", "pass_evalue": "n/a", "pass_bitscore": "700", "ARO_accession": "3004588", "ARO_name": "Klebsiella pneumoniae KpnG", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35957": {"category_aro_accession": "0000039", "category_aro_cvterm_id": "35957", "category_aro_name": "spectinomycin", "category_aro_description": "Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36969": {"category_aro_accession": "3000625", "category_aro_cvterm_id": "36969", "category_aro_name": "polymyxin B1", "category_aro_description": "Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36970": {"category_aro_accession": "3000626", "category_aro_cvterm_id": "36970", "category_aro_name": "polymyxin B2", "category_aro_description": "Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36971": {"category_aro_accession": "3000627", "category_aro_cvterm_id": "36971", "category_aro_name": "polymyxin B3", "category_aro_description": "Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36972": {"category_aro_accession": "3000628", "category_aro_cvterm_id": "36972", "category_aro_name": "polymyxin B4", "category_aro_description": "Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 788.875, "max_identities": 389, "cvterm_id": "42597", "query": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "match": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTAL+QAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "sequence_from_db": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "sequence_from_broadstreet": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "dna_sequence_from_broadstreet": "ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCTGACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACGATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACGGACTACGTGCAGAAAGGCGATCCGCTGGTCACTCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCAACTGGCCGCCAGCGTCCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAGCTGCAGGCAAATATCGACGTCAAAAAAACCGCCCTCTCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTGCAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGATCGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACTGAAGTGCGTAACGCCTGGCTGGCCCTGCAGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATCGGCACCACCACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCGTATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATATGGGTACCGGCAGCGCCTTCTCCCTGCTGCCGGCGCAGAATGCCACCGGCAACTGGATCAAAGTGGTACAGCGCCTGCCGGTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACACCACCGATCGCGATGGTGAAATGCTGGCCAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGCGAAATCGCTCTCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA", "partial": "0", "query_start": 80036, "query_end": 81205, "orf_dna_sequence": "ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCTGACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACGATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACGGACTACGTGCAGAAAGGCGATCCGCTGGTCACGCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCAACTGGCCGCCAGCGTGCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAGCTGCAGGCAAATATCGACGTCAAAAAAACCGCCCTCGCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTGCAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGATCGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACCGAAGTGCGTAACGCCTGGCTGGCCCTGCAGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATTGGCACCACCACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCGTATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATATGGGCACCGGCAGCGCCTTCTCTCTGCTGCCGGCGCAGAATGCCACCGGCAACTGGATCAAAGTGGTACAGCGTCTGCCGGTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACACCACCGATCGCGATGGTGAAATGCTGGCCAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGCGAAATCGCTCTCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA", "orf_prot_sequence": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALAQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "perc_identity": 99.74}}, "NODE_1_length_803036_cov_42.265_82 # 81224 # 82762 # 1 # ID=1_82;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=3-4bp;gc_cont=0.612": {"gnl|BL_ORD_ID|2787|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 81224, "orf_end": 82762, "orf_from": "NODE_1_length_803036_cov_42.265_82", "model_name": "Klebsiella pneumoniae KpnH", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3299", "pass_evalue": "n/a", "pass_bitscore": "700", "ARO_accession": "3004597", "ARO_name": "Klebsiella pneumoniae KpnH", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35957": {"category_aro_accession": "0000039", "category_aro_cvterm_id": "35957", "category_aro_name": "spectinomycin", "category_aro_description": "Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36969": {"category_aro_accession": "3000625", "category_aro_cvterm_id": "36969", "category_aro_name": "polymyxin B1", "category_aro_description": "Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36970": {"category_aro_accession": "3000626", "category_aro_cvterm_id": "36970", "category_aro_name": "polymyxin B2", "category_aro_description": "Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36971": {"category_aro_accession": "3000627", "category_aro_cvterm_id": "36971", "category_aro_name": "polymyxin B3", "category_aro_description": "Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36972": {"category_aro_accession": "3000628", "category_aro_cvterm_id": "36972", "category_aro_name": "polymyxin B4", "category_aro_description": "Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 937.947, "max_identities": 472, "cvterm_id": "42596", "query": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPF", "match": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIP+TGWLAKRVGEVKLFLWST AFAIASWACGVS+SL MLIFFRVIQGIVAGPLIPLSQSLLL+NYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLR RET+TE+RRID VGLALL+IGIGSLQ+MLDRGKELDWFSS EIIILT+VAVVAI FLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVG+IPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRA+TFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTT+WTNRE++HHAQLTESV PFNPNAQ +Y QL+G+GMTQQQASGWIAQQITNQGLIISANEIFW+SA IF++LLGLVWFA+PPF", "sequence_from_db": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLILLGLVWFAKPPF", "sequence_from_broadstreet": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLILLGLVWFAKPPFGAGGGGGGAH", "dna_sequence_from_broadstreet": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAACTGGTCATTATGACGATTGCGCTGTCACTGGCGACATTCATGCAGGTGCTGGACTCCACCATTGCTAACGTGGCGATCCCCACTATCGCCGGGAATCTGGGCTCATCGCTCAGCCAGGGAACGTGGGTAATCACTTCTTTCGGGGTGGCGAATGCCATCTCGATCCCGCTTACCGGCTGGCTGGCAAAGCGCGTCGGGGAAGTGAAACTGTTCCTTTGGTCCACCATCGCCTTTGCTATTGCGTCGTGGGCGTGTGGTGTCTCCAGCAGCCTGAATATGCTGATCTTCTTCCGCGTGATTCAGGGGATTGTCGCCGGGCCGTTGATCCCGCTTTCGCAAAGTCTATTGCTGAATAACTACCCGCCAGCCAAACGCTCGATCGCGCTGGCGTTGTGGTCGATGACGGTGATTGTCGCGCCAATTTGCGGCCCGATCCTCGGCGGTTATATCAGCGATAATTACCACTGGGGCTGGATATTCTTCATCAACGTGCCGATTGGCGTGGCGGTGGTGTTGATGACACTGCAAACTCTGCGCGGACGTGAAACCCGCACCGAACGGCGGCGGATTGATGCCGTGGGGCTGGCACTGCTGGTTATTGGTATCGGCAGCCTGCAGATTATGCTCGACCGCGGTAAAGAGCTGGACTGGTTTTCATCACAGGAAATTATCATCCTTACCGTGGTGGCGGTGGTGGCTATCTGCTTCCTGATTGTCTGGGAGCTGACCGACGATAACCCGATAGTCGATCTGTCGTTGTTTAAGTCGCGCAACTTCACCATCGGCTGCTTGTGTATCAGCCTCGCGTATATGCTCTACTTCGGCGCTATTGTTCTGCTGCCGCAGTTGTTGCAGGAGGTCTACGGTTACACGGCGACCTGGGCAGGTTTGGCCTCTGCGCCGGTAGGGATTATTCCGGTGATCCTGTCGCCGATTATCGGCCGCTTCGCGCATAAACTGGATATGCGGCGGCTGGTAACCTTCAGCTTTATTATGTATGCCGTCTGCTTCTACTGGCGTGCCTATACCTTTGAACCAGGTATGGATTTTGGCGCGTCGGCCTGGCCGCAGTTTATCCAGGGGTTTGCGGTGGCCTGCTTCTTTATGCCGCTGACCACCATTACGCTGTCTGGTTTGCCACCGGAACGACTGGCGGCGGCATCGAGCCTCTCTAACTTTACGCGAACGCTGGCGGGGTCTATCGGCACGTCGATAACCACGACCATGTGGACCAACCGCGAGTCGATGCACCATGCGCAGTTGACTGAGTCGGTAAACCCGTTCAACCCGAATGCCCAGGCGATGTACAGTCAACTGGAAGGGCTTGGGATGACGCAACAGCAGGCATCAGGCTGGATTGCCCAGCAGATCACCAATCAGGGGCTGATTATTTCCGCCAATGAGATCTTCTGGATGTCAGCCGGGATATTCCTCATCCTGCTGGGGCTGGTGTGGTTTGCTAAACCGCCATTTGGCGCAGGTGGCGGCGGAGGCGGTGCGCACTAA", "partial": "0", "query_start": 81224, "query_end": 82729, "orf_dna_sequence": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTGGTCATTATGACCATTGCGCTGTCGCTCGCGACGTTCATGCAGGTGCTGGATTCCACTATCGCCAACGTGGCGATCCCGACCATTGCCGGCAACCTTGGCTCGTCGCTGAGCCAGGGGACCTGGGTCATCACCTCGTTCGGGGTCGCTAACGCCATCTCCATCCCGATCACCGGCTGGCTGGCCAAGCGCGTCGGCGAGGTGAAGCTGTTCCTGTGGTCAACCACCGCCTTCGCCATTGCCTCCTGGGCCTGCGGCGTCTCCAACAGCCTGACGATGCTGATTTTCTTCCGCGTCATTCAGGGGATCGTCGCCGGACCGCTGATCCCGCTGTCGCAAAGTCTGCTGCTCAGCAACTATCCCCCGGCGAAGCGCTCTATCGCTCTGGCGCTGTGGTCAATGACGGTGATTGTCGCGCCCATCTGCGGTCCGATCCTCGGCGGCTATATCAGCGATAACTATCACTGGGGCTGGATCTTCTTTATCAACGTGCCCATTGGCGTGGCGGTGGTGCTGATGACCCTGCAGACCCTGCGCAACCGGGAAACCAAAACCGAACAGCGGCGGATCGACGGTGTCGGTCTGGCGCTGCTGATCATCGGTATCGGTAGCCTGCAGGTGATGCTGGACCGGGGTAAAGAGCTGGACTGGTTCTCCTCCAATGAGATTATCATTCTGACCATCGTGGCGGTGGTGGCGATAAGCTTCCTGATCGTCTGGGAGCTAACCGACGATAACCCGATTGTCGATCTGTCGCTATTTAAGTCGCGCAACTTCACCATCGGCTGCCTCTGTATCAGTCTGGCCTATATGCTCTACTTCGGCGCCATCGTGCTGCTGCCGCAGCTGTTGCAGGAGGTCTACGGTTACACCGCGACCTGGGCCGGCCTGGCGTCGGCGCCGGTGGGGGTGATCCCGGTCATTCTGTCGCCGATTATCGGCCGCTTCGCGCATAAGCTCGACATGCGGCGGCTGGTCACCTTCAGCTTTATTATGTACGCGGTCTGCTTCTACTGGCGCGCCTGGACCTTCGAACCGGGGATGGACTTTGGCGCCTCGGCGTGGCCACAGTTTATCCAGGGCTTCGCGGTGGCCTGCTTCTTCATGCCGTTGACCACCATCACCCTCTCCGGCCTGCCGCCGGAGCGGCTGGCGGCGGCGTCGAGCCTGTCGAACTTCACCCGTACCCTTGCCGGCTCCATCGGGACCTCGATCACCACCACCCTGTGGACCAACCGCGAGGCGCTGCATCATGCGCAGCTCACCGAATCGGTGACCCCCTTTAACCCCAACGCGCAGCAGATATACGATCAGCTGCAGGGCATGGGAATGACGCAGCAGCAGGCGTCCGGCTGGATAGCGCAGCAGATAACCAACCAGGGGCTGATTATCTCCGCCAACGAAATCTTCTGGATTTCTGCGGCTATTTTCATCCTGCTGTTGGGGCTGGTGTGGTTCGCCAGACCACCGTTCAGCGCCGGCGGAGGCGGCGGCGGCGCGCACTAG", "orf_prot_sequence": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPFSAGGGGGGAH", "perc_identity": 94.02}, "gnl|BL_ORD_ID|1745|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 81224, "orf_end": 82762, "orf_from": "NODE_1_length_803036_cov_42.265_82", "model_name": "emrB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1847", "pass_evalue": "n/a", "pass_bitscore": "900", "ARO_accession": "3000074", "ARO_name": "emrB", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 937.947, "max_identities": 472, "cvterm_id": "36849", "query": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPF", "match": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIP+TGWLAKRVGEVKLFLWST AFAIASWACGVS+SL MLIFFRVIQGIVAGPLIPLSQSLLL+NYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLR RET+TE+RRID VGLALL+IGIGSLQ+MLDRGKELDWFSS EIIILT+VAVVAI FLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVG+IPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRA+TFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTT+WTNRE++HHAQLTESV PFNPNAQ +Y QL+G+GMTQQQASGWIAQQITNQGLIISANEIFW+SA IF++LLGLVWFA+PPF", "sequence_from_db": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKPPF", "sequence_from_broadstreet": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKPPFGAGGGGGGAH", "dna_sequence_from_broadstreet": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAACTGGTCATTATGACGATTGCGCTGTCACTGGCGACATTCATGCAGGTGCTGGACTCCACCATTGCTAACGTGGCGATCCCCACTATCGCCGGGAATCTGGGCTCATCGCTCAGCCAGGGAACGTGGGTAATCACTTCTTTCGGGGTGGCGAATGCCATCTCGATCCCGCTTACCGGCTGGCTGGCAAAGCGCGTCGGGGAAGTGAAACTGTTCCTTTGGTCCACCATCGCCTTTGCTATTGCGTCGTGGGCGTGTGGTGTCTCCAGCAGCCTGAATATGCTGATCTTCTTCCGCGTGATTCAGGGGATTGTCGCCGGGCCGTTGATCCCGCTTTCGCAAAGTCTATTGCTGAATAACTACCCGCCAGCCAAACGCTCGATCGCGCTGGCGTTGTGGTCGATGACGGTGATTGTCGCGCCAATTTGCGGCCCGATCCTCGGCGGTTATATCAGCGATAATTACCACTGGGGCTGGATATTCTTCATCAACGTGCCGATTGGCGTGGCGGTGGTGTTGATGACACTGCAAACTCTGCGCGGACGTGAAACCCGCACCGAACGGCGGCGGATTGATGCCGTGGGGCTGGCACTGCTGGTTATTGGTATCGGCAGCCTGCAGATTATGCTCGACCGCGGTAAAGAGCTGGACTGGTTTTCATCACAGGAAATTATCATCCTTACCGTGGTGGCGGTGGTGGCTATCTGCTTCCTGATTGTCTGGGAGCTGACCGACGATAACCCGATAGTCGATCTGTCGTTGTTTAAGTCGCGCAACTTCACCATCGGCTGCTTGTGTATCAGCCTCGCGTATATGCTCTACTTCGGCGCTATTGTTCTGCTGCCGCAGTTGTTGCAGGAGGTCTACGGTTACACGGCGACCTGGGCAGGTTTGGCCTCTGCGCCGGTAGGGATTATTCCGGTGATCCTGTCGCCGATTATCGGCCGCTTCGCGCATAAACTGGATATGCGGCGGCTGGTAACCTTCAGCTTTATTATGTATGCCGTCTGCTTCTACTGGCGTGCCTATACCTTTGAACCAGGTATGGATTTTGGCGCGTCGGCCTGGCCGCAGTTTATCCAGGGGTTTGCGGTGGCCTGCTTCTTTATGCCGCTGACCACCATTACGCTGTCTGGTTTGCCACCGGAACGACTGGCGGCGGCATCGAGCCTCTCTAACTTTACGCGAACGCTGGCGGGGTCTATCGGCACGTCGATAACCACGACCATGTGGACCAACCGCGAGTCGATGCACCATGCGCAGTTGACTGAGTCGGTAAACCCGTTCAACCCGAATGCCCAGGCGATGTACAGTCAACTGGAAGGGCTTGGGATGACGCAACAGCAGGCATCAGGCTGGATTGCCCAGCAGATCACCAATCAGGGGCTGATTATTTCCGCCAATGAGATCTTCTGGATGTCAGCCGGGATATTCCTCGTCCTGCTGGGGCTGGTGTGGTTTGCTAAACCGCCATTTGGCGCAGGTGGCGGCGGAGGCGGTGCGCACTAA", "partial": "0", "query_start": 81224, "query_end": 82729, "orf_dna_sequence": "ATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTGGTCATTATGACCATTGCGCTGTCGCTCGCGACGTTCATGCAGGTGCTGGATTCCACTATCGCCAACGTGGCGATCCCGACCATTGCCGGCAACCTTGGCTCGTCGCTGAGCCAGGGGACCTGGGTCATCACCTCGTTCGGGGTCGCTAACGCCATCTCCATCCCGATCACCGGCTGGCTGGCCAAGCGCGTCGGCGAGGTGAAGCTGTTCCTGTGGTCAACCACCGCCTTCGCCATTGCCTCCTGGGCCTGCGGCGTCTCCAACAGCCTGACGATGCTGATTTTCTTCCGCGTCATTCAGGGGATCGTCGCCGGACCGCTGATCCCGCTGTCGCAAAGTCTGCTGCTCAGCAACTATCCCCCGGCGAAGCGCTCTATCGCTCTGGCGCTGTGGTCAATGACGGTGATTGTCGCGCCCATCTGCGGTCCGATCCTCGGCGGCTATATCAGCGATAACTATCACTGGGGCTGGATCTTCTTTATCAACGTGCCCATTGGCGTGGCGGTGGTGCTGATGACCCTGCAGACCCTGCGCAACCGGGAAACCAAAACCGAACAGCGGCGGATCGACGGTGTCGGTCTGGCGCTGCTGATCATCGGTATCGGTAGCCTGCAGGTGATGCTGGACCGGGGTAAAGAGCTGGACTGGTTCTCCTCCAATGAGATTATCATTCTGACCATCGTGGCGGTGGTGGCGATAAGCTTCCTGATCGTCTGGGAGCTAACCGACGATAACCCGATTGTCGATCTGTCGCTATTTAAGTCGCGCAACTTCACCATCGGCTGCCTCTGTATCAGTCTGGCCTATATGCTCTACTTCGGCGCCATCGTGCTGCTGCCGCAGCTGTTGCAGGAGGTCTACGGTTACACCGCGACCTGGGCCGGCCTGGCGTCGGCGCCGGTGGGGGTGATCCCGGTCATTCTGTCGCCGATTATCGGCCGCTTCGCGCATAAGCTCGACATGCGGCGGCTGGTCACCTTCAGCTTTATTATGTACGCGGTCTGCTTCTACTGGCGCGCCTGGACCTTCGAACCGGGGATGGACTTTGGCGCCTCGGCGTGGCCACAGTTTATCCAGGGCTTCGCGGTGGCCTGCTTCTTCATGCCGTTGACCACCATCACCCTCTCCGGCCTGCCGCCGGAGCGGCTGGCGGCGGCGTCGAGCCTGTCGAACTTCACCCGTACCCTTGCCGGCTCCATCGGGACCTCGATCACCACCACCCTGTGGACCAACCGCGAGGCGCTGCATCATGCGCAGCTCACCGAATCGGTGACCCCCTTTAACCCCAACGCGCAGCAGATATACGATCAGCTGCAGGGCATGGGAATGACGCAGCAGCAGGCGTCCGGCTGGATAGCGCAGCAGATAACCAACCAGGGGCTGATTATCTCCGCCAACGAAATCTTCTGGATTTCTGCGGCTATTTTCATCCTGCTGTTGGGGCTGGTGTGGTTCGCCAGACCACCGTTCAGCGCCGGCGGAGGCGGCGGCGGCGCGCACTAG", "orf_prot_sequence": "MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPITGWLAKRVGEVKLFLWSTTAFAIASWACGVSNSLTMLIFFRVIQGIVAGPLIPLSQSLLLSNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRNRETKTEQRRIDGVGLALLIIGIGSLQVMLDRGKELDWFSSNEIIILTIVAVVAISFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGVIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTLWTNREALHHAQLTESVTPFNPNAQQIYDQLQGMGMTQQQASGWIAQQITNQGLIISANEIFWISAAIFILLLGLVWFARPPFSAGGGGGGAH", "perc_identity": 94.02}}, "NODE_3_length_454317_cov_40.2449_14 # 17656 # 20778 # 1 # ID=3_14;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.646": {"gnl|BL_ORD_ID|774|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 17656, "orf_end": 20778, "orf_from": "NODE_3_length_454317_cov_40.2449_14", "model_name": "mdtB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "820", "pass_evalue": "n/a", "pass_bitscore": "1800", "ARO_accession": "3000793", "ARO_name": "mdtB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1835.85, "max_identities": 937, "cvterm_id": "36849", "query": "MQVLPPGRTGGPSRLFIMRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAIPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETVRTAITSANVNSAKGSLDGPARAVTLSANDQMQSAEDYRRLIIAYQNGAPIRLGDVASVEQGAENSWLGAWANQQRAIVMNVQRQPGANIIDTADSIRQMLPQLTESLPKSVKVQVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNVPATIIPGVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERFFERVIAVYGRWLSRVLNHPWLTLGVALSTLALSIILWVFIPKGFFPIQDNGIIQGTLQAPQSVSFASMAERQRQVASIILKDPAVESLTSFVGVDGTNPALNSARLQINLKPLDERDDRVQTVISRLQQAVDGVPGVALYLQPTQDLTIDTTVSRTQYQFTLQANSLEALSTWVPPLLSRLQAQPQLADVSSDWQDKGLAAYIKVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEQDTEATPGLAALENIRLTSSDGGIVPLTAIATVEQRFTPLSVNHLDQFPVTTISFNVPDNYSLGEAVEAILAAEQSLDFPTDIRTQFQGSSLAFQSALGSTVWLVVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALWLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMPPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLMLSQVLTLFTTPVIYLLFDRLSLHLKRRFPRQEEEA", "match": "MQVLPP  TGGPSRLFIMRPVATTLLMVAILLAGIIGYR LPVSALPEVDYPTIQVVTLYPGASPDV+TSA+TAPLERQFGQMSGLKQMSSQSSGGASV+TLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTS+A+PMTQVEDMVETRVAQKISQ+SGVGLVTL+GGQRPAVRVKLNAQAIAALGLTSETVRTAIT ANVNSAKGSLDGP+RAVTLSANDQMQSAE+YR+LIIAYQNGAPIRLGDVA+VEQGAENSWLGAWAN+++AIVMNVQRQPGANII TADSIRQMLPQLTESLPKSVKV VLSDRTTNIRASV DTQFELM+AIALVVMIIYLFLRN+PATIIPGVAVPLSL+GTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFA+TLAVAILISAVVSLTLTPMMCARMLS ESLRKQNRFSRASE+ F+R+IA YGR L++VLNHPWLTL VALSTL LS++LWVFIPKGFFP+QDNGIIQGTLQAPQS SFA+MA+RQRQVA +IL+DPAV+SLTSFVGVDGTNP+LNSARLQINLKPLDERDDRVQ VI+RLQ AVD VPGV L+LQPTQDLTIDT VSRTQYQFTLQA SL+ALSTWVP L+ +LQ  PQL+DVSSDWQDKGL AY+ VDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLE +TE TPGLAAL+ IRLTSSDGG+VPL++IA +EQRF PLS+NHLDQFPVTTISFNVPDNYSLG+AV+AI+  E++L+ P DI TQFQGS+LAFQSALGSTVWL+VAAVVAMYIVLG+LYESFIHPITILSTLPTAGVGALLAL +AGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGM PREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGL++SQVLTLFTTPVIYLLFDRL+L  K RF R EEEA", "sequence_from_db": "MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA", "sequence_from_broadstreet": "MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA", "dna_sequence_from_broadstreet": "ATGCAGGTGTTACCCCCGAGCAGCACAGGCGGCCCGTCGCGCCTGTTTATTATGCGTCCTGTGGCCACCACGCTGCTGATGGTGGCGATCTTACTCGCCGGGATTATCGGTTATCGCGCCCTGCCCGTTTCGGCGCTGCCGGAAGTGGACTATCCGACCATTCAGGTGGTCACGCTCTACCCAGGTGCCAGCCCGGATGTCATGACCTCTGCCGTTACCGCGCCGCTAGAACGCCAGTTCGGGCAGATGTCTGGCCTGAAACAGATGTCGTCGCAAAGTTCCGGCGGTGCGTCAGTTATCACTTTGCAGTTCCAGCTAACATTACCGCTCGATGTCGCCGAGCAGGAAGTGCAGGCCGCGATTAACGCTGCGACCAACTTGTTGCCGAGCGATCTGCCTAACCCGCCGGTTTACAGCAAAGTGAACCCGGCAGATCCGCCGATCATGACGCTCGCCGTCACCTCAACCGCCATGCCGATGACGCAAGTGGAAGATATGGTGGAAACCCGCGTCGCGCAGAAAATCTCGCAGATTTCCGGCGTCGGCCTGGTGACGCTTTCCGGCGGTCAGCGTCCGGCTGTTCGCGTCAAACTTAACGCTCAGGCGATTGCCGCCCTCGGCCTGACCAGCGAAACCGTGCGCACCGCCATTACCGGCGCTAACGTTAACTCGGCAAAAGGTAGCCTCGACGGCCCTTCCCGTGCGGTCACGCTTTCCGCGAACGACCAGATGCAATCCGCCGAAGAGTATCGCCAGCTAATCATCGCCTACCAGAACGGCGCGCCAATTCGTCTGGGCGATGTCGCAACTGTAGAGCAAGGTGCAGAAAACAGCTGGCTCGGCGCGTGGGCGAACAAAGAACAGGCCATTGTGATGAATGTTCAGCGCCAGCCCGGTGCTAACATTATCTCCACCGCCGACAGCATTCGGCAGATGCTGCCACAGCTCACTGAGAGTCTGCCGAAATCGGTGAAGGTGACAGTGCTTTCCGATCGCACCACCAATATCCGCGCATCCGTCGATGATACTCAGTTTGAATTGATGATGGCTATCGCGCTGGTAGTCATGATTATCTACCTGTTTTTGCGCAATATTCCGGCGACCATCATTCCCGGTGTTGCTGTACCGCTGTCGTTAATCGGCACTTTCGCGGTTATGGTGTTTCTCGATTTTTCAATCAATAACCTGACACTGATGGCGTTAACTATCGCCACCGGATTCGTGGTCGATGACGCCATCGTGGTGATCGAAAACATTTCCCGCTATATCGAAAAAGGCGAAAAACCGTTGGCGGCGGCGCTCAAGGGCGCAGGTGAAATCGGCTTTACCATTATCTCGCTGACCTTCTCACTGATTGCGGTGTTGATCCCACTGCTGTTTATGGGCGATATCGTCGGGCGACTGTTCCGCGAATTTGCTATTACCCTGGCGGTAGCGATTTTGATCTCAGCGGTGGTGTCGCTGACCCTGACACCGATGATGTGCGCGCGGATGCTCAGCCAGGAGTCGTTGCGTAAACAGAACCGCTTCTCCCGTGCCTCGGAAAAAATGTTCGACAGGATAATCGCCGCCTATGGTCGTGGACTGGCGAAAGTGCTGAATCATCCGTGGCTGACCTTAAGCGTGGCACTCAGCACGCTGCTGCTTAGCGTGCTGCTGTGGGTGTTCATTCCGAAAGGTTTCTTCCCGGTACAGGACAATGGCATTATTCAGGGCACTTTGCAGGCACCGCAATCCAGCTCCTTTGCCAATATGGCCCAGCGACAACGCCAGGTCGCGGACGTGATTTTGCAGGATCCGGCAGTGCAAAGCCTGACCTCATTTGTTGGCGTTGATGGCACTAACCCGTCGCTGAACAGTGCACGTTTACAAATCAACCTCAAACCGTTGGATGAACGTGATGATCGGGTGCAAAAAGTCATCGCCCGTCTGCAAACGGCGGTAGATAAAGTGCCGGGCGTCGATCTCTTCCTGCAACCAACGCAGGATCTGACTATTGATACTCAGGTCAGCCGCACCCAGTACCAGTTTACCTTGCAGGCCACGTCACTGGATGCGCTCAGTACCTGGGTGCCACAGTTGATGGAAAAACTCCAGCAACTGCCACAGCTTTCTGATGTCTCCAGCGACTGGCAGGACAAAGGGCTGGTGGCGTATGTCAATGTTGATCGCGACAGCGCCAGCCGTCTGGGGATCAGCATGGCGGATGTCGATAACGCCCTGTACAACGCGTTTGGTCAGCGGCTGATTTCCACTATTTATACTCAGGCCAACCAGTATCGCGTGGTGCTGGAGCACAACACCGAAAATACCCCAGGCCTCGCGGCGCTGGATACCATTCGCCTGACCAGCAGCGACGGCGGCGTGGTGCCGCTAAGCTCAATTGCCAAAATTGAGCAGCGTTTTGCGCCGCTCTCCATCAACCATCTGGATCAGTTCCCGGTAACGACCATCTCCTTTAACGTGCCGGATAACTATTCGCTGGGCGATGCGGTGCAGGCGATTATGGACACCGAAAAGACGCTGAATCTGCCGGTGGATATCACCACGCAGTTCCAGGGCAGCACCCTCGCCTTCCAGTCGGCGCTGGGCAGCACTGTCTGGCTGATTGTCGCGGCGGTGGTGGCGATGTATATCGTGCTCGGCATTCTGTACGAGAGCTTTATTCACCCGATCACCATTCTCTCGACGCTACCCACCGCAGGGGTTGGCGCACTGCTGGCGTTGCTGATTGCTGGTAGCGAACTGGATGTGATTGCGATTATCGGCATTATTTTGCTGATCGGTATCGTGAAGAAGAACGCCATCATGATGATCGACTTCGCGCTGGCTGCTGAGCGCGAGCAAGGCATGTCGCCGCGCGAGGCAATCTACCAGGCTTGTCTGTTGCGTTTTCGTCCGATCCTGATGACCACTCTGGCGGCTCTGCTTGGCGCGCTGCCGCTGATGTTGAGTACCGGGGTCGGCGCGGAACTGCGTCGTCCGTTAGGTATCGGCATGGTCGGCGGTCTGATTGTCAGCCAGGTGCTGACGCTGTTTACCACGCCGGTGATTTATTTGCTGTTCGACCGCCTGGCATTGTGGACCAAAAGCCGCTTTGCCCGTCATGAAGAGGAGGCGTAA", "partial": "0", "query_start": 17656, "query_end": 20775, "orf_dna_sequence": "ATGCAGGTGTTACCCCCAGGCCGCACCGGCGGCCCGTCCCGGCTGTTTATTATGCGTCCGGTGGCCACCACTCTGCTGATGGTGGCTATCCTGCTGGCCGGGATCATCGGCTACCGCTTTCTGCCGGTCTCCGCCCTGCCGGAGGTCGATTACCCGACCATTCAGGTAGTCACCCTCTATCCGGGCGCCAGCCCGGACGTGGTGACCTCCGCCATCACCGCCCCGCTGGAGCGCCAGTTCGGCCAAATGTCAGGCCTCAAGCAGATGTCGTCGCAAAGCTCCGGCGGCGCCTCGGTAGTCACGCTGCAGTTCCAGCTGACCCTGCCGCTGGACGTCGCCGAGCAGGAAGTGCAGGCGGCCATTAACGCCGCCACCAACCTGCTGCCGAGCGATCTGCCCAACCCGCCGGTCTACAGCAAGGTGAACCCGGCGGATCCGCCGATCATGACTCTCGCCGTCACCTCCTCCGCCATCCCGATGACCCAGGTTGAGGACATGGTGGAGACCCGGGTGGCGCAGAAGATCTCCCAGGTTTCCGGCGTCGGTCTGGTGACCCTCGCCGGCGGCCAGCGCCCGGCGGTGCGGGTGAAGCTTAACGCCCAGGCCATCGCCGCCCTCGGCCTGACCAGCGAAACCGTGCGCACCGCTATCACCAGCGCCAACGTTAACTCCGCGAAAGGCAGCCTCGACGGTCCGGCCCGCGCGGTGACGCTTTCCGCTAACGATCAGATGCAGTCCGCTGAGGATTATCGCCGGCTGATTATCGCTTATCAGAACGGGGCGCCGATCCGGCTCGGCGATGTCGCCAGCGTCGAACAAGGGGCCGAAAACAGCTGGCTCGGGGCGTGGGCCAACCAGCAGCGGGCCATCGTGATGAACGTCCAGCGCCAGCCGGGGGCCAACATCATCGACACCGCCGACAGCATTCGCCAGATGCTGCCGCAGCTTACCGAGAGCCTGCCGAAATCGGTGAAGGTGCAGGTCCTCTCCGACCGGACCACCAACATCCGCGCCTCGGTGCGCGACACCCAGTTTGAGCTGATGCTGGCCATCGCCCTGGTGGTGATGATCATCTACCTGTTTCTGCGCAACGTGCCGGCGACCATTATTCCCGGCGTCGCGGTGCCGCTGTCGCTGGTGGGCACTTTCGCGGTGATGGTGTTCCTCGACTTCTCGATCAACAACCTGACGCTGATGGCCCTGACCATCGCCACCGGCTTCGTGGTGGATGATGCCATCGTGGTGATCGAGAACATCTCGCGCTATATCGAAAAAGGCGAGAAGCCGCTGGCCGCCGCGCTGAAGGGCGCGGGGGAGATCGGCTTCACCATCATCTCCCTCACCTTCTCGCTGATCGCGGTGCTGATCCCGCTGCTGTTTATGGGCGATATCGTCGGCCGCCTGTTCCGCGAATTCGCCGTCACCCTTGCCGTCGCTATTCTTATCTCGGCGGTGGTCTCCCTGACCCTGACGCCGATGATGTGCGCTCGTATGCTAAGCCACGAATCGCTGCGCAAGCAGAACCGATTCTCGCGGGCCAGCGAGCGTTTCTTCGAACGGGTGATCGCCGTCTATGGCCGCTGGCTGAGCCGGGTGCTGAACCATCCGTGGCTGACGCTCGGCGTCGCCCTGAGCACCCTGGCGCTGTCGATTATCCTGTGGGTCTTTATCCCGAAAGGCTTTTTCCCGATCCAGGATAACGGCATTATCCAGGGTACCCTCCAGGCGCCGCAGTCGGTCTCCTTCGCCAGCATGGCCGAGCGCCAGCGGCAGGTGGCCAGCATTATCCTTAAGGATCCGGCGGTGGAGAGTCTGACCTCCTTCGTCGGCGTCGACGGCACCAACCCGGCGCTGAACAGCGCCCGTCTGCAGATCAACCTCAAGCCGCTGGATGAACGCGACGATCGCGTCCAGACGGTGATAAGCCGCCTGCAGCAGGCGGTGGACGGCGTCCCCGGCGTGGCGCTCTACCTGCAGCCGACCCAGGACCTGACCATCGACACCACGGTGAGCCGCACCCAGTATCAGTTCACCCTGCAGGCAAACTCCCTCGAGGCGCTGAGCACCTGGGTACCGCCGCTGCTCAGCCGTCTGCAGGCCCAGCCGCAGCTGGCCGACGTCAGCAGCGACTGGCAGGACAAAGGCCTGGCCGCCTATATCAAGGTGGATCGCGACAGCGCCAGCCGCCTCGGTATCTCAATGGCCGATGTCGATAATGCGCTGTACAACGCCTTCGGCCAGCGGCTGATCTCCACTATTTACACTCAGGCGAATCAGTATCGCGTGGTGCTCGAGCAGGATACCGAGGCGACGCCGGGCCTGGCGGCGCTGGAGAATATCCGTCTCACCAGCAGCGACGGCGGCATCGTGCCGTTGACCGCCATCGCCACGGTGGAGCAGCGCTTTACCCCGCTGTCGGTGAACCACCTCGATCAGTTCCCGGTGACCACCATCTCGTTTAACGTCCCGGACAACTACTCGCTGGGCGAAGCGGTGGAGGCGATCCTCGCCGCCGAACAGTCGCTGGATTTCCCGACCGATATTCGCACCCAGTTCCAGGGCAGCTCGCTGGCCTTCCAGTCGGCGCTCGGCAGCACCGTCTGGCTGGTGGTCGCCGCGGTGGTGGCGATGTATATCGTGCTGGGGGTGCTGTACGAGAGCTTTATCCATCCGATCACGATTCTCTCCACCCTGCCCACCGCCGGGGTCGGGGCGCTGCTGGCGCTGTGGCTGGCGGGCAGCGAGCTGGACGTGATCGCCATCATCGGAATCATTCTGCTGATCGGCATCGTGAAGAAGAACGCCATCATGATGATCGACTTCGCGCTGGCCGCTGAGCGCGAGCAGGGCATGCCGCCGCGGGAGGCGATCTACCAGGCCTGTCTGCTGCGTTTTCGGCCGATCCTGATGACTACCCTCGCCGCCCTGCTCGGCGCCCTGCCGCTGATGCTGAGCACCGGCGTCGGCGCCGAGCTGCGGCGTCCGCTGGGGATCGGCATGGTCGGCGGTCTGATGCTCAGCCAGGTGCTGACCCTGTTCACCACCCCGGTGATCTATCTGCTGTTCGACCGCCTGTCGCTGCACCTGAAGCGCCGCTTCCCGCGTCAGGAAGAGGAGGCGTAA", "orf_prot_sequence": "MQVLPPGRTGGPSRLFIMRPVATTLLMVAILLAGIIGYRFLPVSALPEVDYPTIQVVTLYPGASPDVVTSAITAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSSAIPMTQVEDMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETVRTAITSANVNSAKGSLDGPARAVTLSANDQMQSAEDYRRLIIAYQNGAPIRLGDVASVEQGAENSWLGAWANQQRAIVMNVQRQPGANIIDTADSIRQMLPQLTESLPKSVKVQVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNVPATIIPGVAVPLSLVGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSHESLRKQNRFSRASERFFERVIAVYGRWLSRVLNHPWLTLGVALSTLALSIILWVFIPKGFFPIQDNGIIQGTLQAPQSVSFASMAERQRQVASIILKDPAVESLTSFVGVDGTNPALNSARLQINLKPLDERDDRVQTVISRLQQAVDGVPGVALYLQPTQDLTIDTTVSRTQYQFTLQANSLEALSTWVPPLLSRLQAQPQLADVSSDWQDKGLAAYIKVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEQDTEATPGLAALENIRLTSSDGGIVPLTAIATVEQRFTPLSVNHLDQFPVTTISFNVPDNYSLGEAVEAILAAEQSLDFPTDIRTQFQGSSLAFQSALGSTVWLVVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALWLAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMPPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLMLSQVLTLFTTPVIYLLFDRLSLHLKRRFPRQEEEA", "perc_identity": 90.1}}, "NODE_3_length_454317_cov_40.2449_15 # 20779 # 23856 # 1 # ID=3_15;partial=00;start_type=GTG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.638": {"gnl|BL_ORD_ID|1239|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 20779, "orf_end": 23856, "orf_from": "NODE_3_length_454317_cov_40.2449_15", "model_name": "mdtC", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1315", "pass_evalue": "n/a", "pass_bitscore": "1800", "ARO_accession": "3000794", "ARO_name": "mdtC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1862.04, "max_identities": 937, "cvterm_id": "36849", "query": "MKFFALFIYRPVATILISLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVDLNPQALFNQGVSLDAVRTAISDANVRKPQGALEDSAHRWQVQTNDELKTAADYQPLIVHYQNGAAVRLGDVATVSDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRARLPELQQTIPAAIDLQIAQDRSPTIRASLEEVEQTLVISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGSREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLAVSLTLTPMMCGWLLKSGKPHQPTRNRGFGRLLVAMQGGYGKSLKWVLKHSRLTGLVVLGTIVLSVWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIREDPAVDNVTGFTGGSRVNSGMMFITLKPRDQRHETAQQVIDRLRKKLANEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLSALREWEPKIRKALAALPELADVNSDQQDNGAEMDLVYDRDTMSRLGISVQDANNLLNNAFGQRQISTIYQPLNQYKVVMEVDPAYTQDVSALDKMFVINSDGKPIPLAYFAKWQPANAPLSVNHQGLSAASTISFNLPTGRSLSEASEAIDRAMTQLGVPSSVRGSFAGTAHVFQQTMNAQVILILAAIATVYIVLGVLYESYVHPLTILSTLPSAGVGALLALEIFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTPEEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRHSSQPVSE", "match": "MKFFALFIYRPVATIL+S+AITLCGILGFR+LPVAPLPQVDFPVI+VSASLPGASPETMASSVATPLERSLGRIAGV+EMTSSSSLGSTRIIL+F+FDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLA TI+QIDGVGDVDVGGSSLPAVRV LNPQALFNQGVSLD VRTA+S+ANVRKPQGALED  HRWQ+QTNDELKTAA+YQPLI+HY NG AVRLGDVATV+DSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRA+LPELQ+TIPAAIDLQIAQDRSPTIRASLEEVEQTL+ISVALVILVVFLFLRSGRAT+IPAV+VPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENI+RHLEAGMKPLQAALQG+REVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISL VSLTLTPMMCGW+LK+ KP +  R RGFGR+LVA+Q GYGKSLKWVL H+RL G+V+LGTI L++WLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIR+DPAVDNVTGFTGGSRVNSGMMFITLKPRD+R ETAQQ+IDRLR KLA EPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDL+ALREWEPKIRK LA LPELADVNSDQQDNGAEM+LVYDRDTM+RLGI VQ AN+LLNNAFGQRQISTIYQP+NQYKVVMEVDP YTQD+SAL+KMFVIN++GK IPL+YFAKWQPANAPLSVNHQGLSAASTISFNLPTG+SLS+AS AIDRAMTQLGVPS+VRGSFAGTA VFQ+TMN+QVILI+AAIATVYIVLG+LYESYVHPLTILSTLPSAGVGALLALE+F+APFSLIALIGIMLLIGIVKKNAIMMVDFALEAQR+GNLTP+EAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSR   Q V+E", "sequence_from_db": "MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE", "sequence_from_broadstreet": "MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE", "dna_sequence_from_broadstreet": "GTGAAGTTTTTTGCCCTCTTCATTTACCGCCCGGTGGCGACGATTTTACTGTCGGTTGCCATTACCCTGTGCGGCATACTGGGCTTCCGTATGCTGCCGGTCGCCCCGCTGCCGCAGGTCGATTTTCCGGTGATTATCGTCAGCGCCTCGCTGCCCGGTGCGTCACCAGAAACAATGGCGTCTTCCGTTGCCACGCCGCTGGAGCGCTCACTTGGGCGCATTGCCGGAGTCAGTGAAATGACCTCCAGCAGTTCGCTCGGCAGCACGCGTATTATTTTGCAGTTTGATTTTGACCGGGATATCAACGGCGCAGCGCGTGATGTGCAGGCGGCGATCAACGCTGCACAAAGTTTGCTGCCCAGTGGGATGCCCAGCCGCCCGACCTATCGCAAAGCGAACCCGTCGGATGCGCCAATTATGATCCTCACGCTGACGTCCGATACTTATTCGCAGGGTGAACTGTACGATTTCGCCTCGACGCAGCTGGCTCCGACGATTTCGCAAATCGACGGTGTTGGTGATGTCGATGTCGGAGGCAGCTCACTGCCCGCCGTACGCGTCGGGCTGAATCCGCAGGCGCTGTTTAATCAGGGCGTGTCGCTGGACGACGTACGCACCGCCGTCAGCAATGCCAACGTGCGTAAACCGCAGGGCGCGCTGGAAGATGGCACTCACCGCTGGCAGATCCAGACCAATGATGAGCTAAAAACCGCCGCTGAATATCAGCCGTTGATTATTCACTACAACAACGGCGGCGCGGTTCGTCTGGGCGATGTGGCGACGGTGACCGACTCAGTGCAGGATGTGCGCAACGCCGGGATGACCAACGCCAAACCGGCTATTTTACTGATGATCCGCAAACTGCCGGAAGCCAATATTATCCAGACGGTTGACAGCATCCGGGCAAAATTACCGGAGTTGCAGGAAACCATTCCGGCGGCGATTGATCTGCAAATTGCCCAGGATCGCTCCCCCACCATTCGCGCCTCGCTGGAAGAAGTCGAGCAAACGCTGATTATCTCGGTGGCGCTGGTGATTCTGGTGGTGTTTTTATTCCTGCGCTCGGGTCGCGCCACTATTATTCCCGCCGTTTCGGTGCCGGTTTCGCTGATTGGTACGTTTGCGGCGATGTACCTGTGCGGATTCAGTCTCAATAACCTTTCGTTAATGGCGCTCACCATCGCTACTGGTTTCGTGGTGGATGACGCCATCGTGGTGCTGGAAAACATTGCACGTCATCTGGAAGCGGGAATGAAACCGTTGCAAGCCGCACTGCAAGGTACTCGCGAAGTCGGTTTTACGGTGCTGTCGATGAGTCTGTCACTGGTGGCGGTGTTCCTGCCGCTGCTGTTGATGGGCGGATTGCCGGGCCGACTGTTACGCGAATTTGCCGTGACGCTTTCTGTCGCCATTGGTATATCGTTGCTGGTTTCTCTGACATTAACGCCAATGATGTGTGGCTGGATGCTGAAAGCCAGCAAGCCGCGCGAGCAAAAGCGACTGCGTGGTTTTGGTCGCATGTTGGTAGCCCTGCAACAAGGCTACGGCAAGTCACTAAAATGGGTGCTCAATCATACCCGTCTGGTGGGCGTGGTGCTGCTTGGCACCATTGCGCTGAATATCTGGCTGTATATCTCGATCCCGAAAACCTTCTTCCCGGAGCAGGACACTGGCGTGTTGATGGGCGGGATTCAGGCGGATCAGAGTATTTCGTTTCAGGCGATGCGCGGTAAGTTGCAGGATTTCATGAAAATTATCCGTGACGATCCGGCAGTGGATAATGTCACCGGCTTTACAGGCGGTTCGCGAGTGAACAGCGGGATGATGTTTATCACCCTCAAGCCACGCGACGAACGCAGCGAAACGGCGCAGCAAATTATCGACCGTCTGCGCGTAAAACTGGCGAAAGAACCGGGGGCGAATCTGTTCCTGATGGCGGTACAGGATATTCGCGTTGGTGGGCGTCAGTCGAACGCCAGCTACCAGTACACGTTGTTATCCGACGACCTGGCGGCACTGCGAGAATGGGAGCCGAAAATCCGCAAAAAACTGGCGACGTTGCCGGAACTGGCGGACGTGAACTCCGATCAGCAGGATAACGGCGCGGAGATGAATCTGGTTTACGACCGCGACACCATGGCACGGCTGGGAATCGACGTACAAGCCGCCAACAGTCTGTTAAATAACGCCTTCGGTCAGCGGCAAATCTCGACCATTTACCAGCCGATGAACCAGTATAAAGTGGTGATGGAAGTGGATCCGCGCTATACCCAGGACATCAGTGCGCTGGAAAAAATGTTCGTTATCAATAACGAAGGCAAAGCGATCCCGCTGTCGTATTTCGCTAAATGGCAACCGGCGAATGCCCCACTATCGGTGAATCATCAGGGATTATCGGCGGCCTCGACCATTTCGTTTAACCTGCCGACCGGAAAATCGCTCTCGGACGCCAGTGCGGCGATCGATCGCGCAATGACCCAGCTTGGTGTGCCTTCGACGGTGCGCGGCAGTTTTGCCGGCACGGCGCAGGTGTTCCAGGAGACGATGAACTCGCAGGTGATCCTGATTATCGCCGCCATCGCCACGGTGTATATCGTGCTGGGTATCCTTTACGAGAGTTACGTACATCCGCTGACGATTCTCTCCACCCTGCCCTCGGCGGGCGTTGGAGCGCTGTTGGCGCTGGAGCTGTTCAATGCCCCGTTCAGCCTAATCGCCCTGATAGGGATCATGCTATTAATCGGCATCGTGAAGAAAAACGCCATTATGATGGTCGATTTTGCGCTTGAAGCCCAACGGCACGGTAACCTGACGCCGCAGGAAGCTATTTTCCAGGCCTGTCTGCTGCGTTTTCGCCCGATTATGATGACTACCCTGGCGGCGCTGTTTGGTGCGCTGCCGCTGGTATTGTCGGGCGGCGACGGCTCGGAGCTGCGGCAACCCCTGGGGATCACCATTGTCGGCGGACTGGTAATGAGCCAGCTCCTTACGCTGTATACCACGCCGGTGGTGTATCTCTTTTTCGACCGTCTGCGGCTGCGTTTTTCGCGTAAACCTAAACAAACGGTAACCGAGTAA", "partial": "0", "query_start": 20779, "query_end": 23853, "orf_dna_sequence": "GTGAAGTTTTTCGCCCTCTTCATTTACCGCCCGGTGGCGACGATCCTCATCTCGCTGGCCATCACCCTGTGCGGCATTCTCGGCTTCCGGCTGCTGCCGGTAGCCCCGCTGCCGCAGGTGGACTTCCCGGTGATCATGGTTAGCGCCTCGCTGCCGGGAGCCTCGCCGGAGACCATGGCCTCGTCGGTGGCCACCCCACTGGAGCGCTCCCTGGGGCGGATTGCCGGGGTCAATGAGATGACCTCCTCCAGCTCGCTCGGCAGCACCCGCATCATTCTTGAGTTTAACTTCGACCGCGATATCAACGGCGCGGCGCGCGACGTTCAGGCGGCGATCAACGCCGCGCAAAGCCTGCTGCCGAGCGGAATGCCCAGCCGGCCGACCTATCGCAAAGCTAATCCGTCAGATGCGCCGATCATGATCCTGACGCTGACCTCGGACACCTACTCCCAGGGTGAGCTGTATGATTTCGCCTCCACCCAGCTGGCGCAGACCATCGCGCAGATCGACGGCGTGGGCGATGTCGACGTCGGCGGCAGCTCCCTGCCGGCGGTGCGCGTCGACCTCAACCCGCAGGCGCTGTTTAACCAGGGCGTGTCGCTGGACGCGGTGCGCACCGCCATCAGCGACGCCAACGTGCGCAAACCGCAGGGGGCGCTGGAGGACAGCGCGCACCGCTGGCAGGTGCAGACCAACGATGAGCTGAAGACCGCCGCCGACTATCAGCCGCTGATCGTCCACTACCAGAATGGCGCCGCGGTGCGGCTGGGAGATGTCGCCACCGTCTCGGATTCGGTGCAGGACGTACGCAACGCCGGGATGACCAACGCCAAACCGGCGATCCTGCTGATGATCCGCAAACTGCCGGAAGCCAATATTATCCAGACGGTGGACAGCATCCGCGCCCGCCTGCCGGAGCTGCAGCAGACCATTCCGGCGGCTATCGACCTGCAGATCGCCCAGGACCGCTCGCCGACCATCCGCGCCTCGCTGGAGGAGGTGGAGCAGACGCTGGTGATTTCGGTGGCGCTGGTGATCCTCGTGGTGTTCCTGTTCCTGCGCTCGGGGCGCGCCACGCTGATCCCGGCCGTCGCCGTCCCGGTATCCTTAATCGGTACCTTCGCCGCGATGTATTTGTGCGGCTTCAGCCTCAATAACCTGTCGCTGATGGCCCTGACCATCGCCACCGGCTTCGTGGTGGATGACGCTATCGTGGTGCTGGAGAATATCTCCCGCCATCTGGAGGCGGGGATGAAACCGCTGCAGGCGGCGCTGCAGGGGAGCCGCGAGGTCGGCTTTACCGTGCTGTCGATGAGCCTGTCGCTGGTGGCGGTGTTTCTGCCGCTGCTGCTGATGGGCGGCCTGCCCGGCCGCCTGCTGCGCGAGTTCGCCGTCACCCTGTCGGTGGCGATCGGCATCTCGCTGGCGGTCTCCCTCACCCTGACGCCGATGATGTGCGGCTGGCTGCTGAAAAGCGGCAAGCCCCACCAGCCGACGCGCAACCGCGGCTTTGGCCGCCTGCTGGTGGCCATGCAGGGCGGCTATGGTAAATCGTTAAAATGGGTACTGAAGCACAGCCGGCTGACCGGCCTGGTGGTGCTGGGCACCATCGTCCTCAGCGTTTGGCTCTACATTTCGATCCCGAAAACCTTCTTCCCGGAGCAGGACACCGGGGTGCTGATGGGCGGCATTCAGGCCGACCAGAGCATCTCCTTCCAGGCGATGCGCGGCAAGCTGCAGGACTTTATGAAGATCATTCGCGAAGATCCGGCGGTGGATAACGTCACCGGCTTTACCGGCGGCTCGCGGGTCAACAGCGGGATGATGTTTATCACCCTCAAGCCGCGCGACCAGCGCCACGAGACGGCGCAGCAGGTGATCGACCGGCTGCGCAAAAAGCTGGCCAACGAGCCCGGGGCCAACCTGTTCCTGATGGCGGTGCAGGATATCCGCGTCGGCGGCCGGCAGTCGAACGCCAGCTATCAGTACACCCTGCTGTCCGACGACCTGTCGGCGCTGCGCGAGTGGGAGCCGAAGATCCGCAAAGCGCTGGCGGCGCTGCCGGAGCTGGCGGACGTCAACTCCGATCAGCAGGACAATGGCGCCGAAATGGACCTGGTCTATGACCGGGATACCATGTCGCGCCTCGGCATCAGCGTCCAGGACGCCAACAACCTGCTGAACAACGCCTTTGGCCAGCGGCAGATCTCTACCATCTACCAGCCGCTCAACCAGTATAAGGTGGTGATGGAGGTGGATCCGGCCTACACCCAGGACGTCAGCGCCCTGGATAAGATGTTCGTCATTAACAGCGACGGCAAGCCGATCCCGCTGGCCTACTTCGCCAAATGGCAGCCGGCCAATGCCCCGCTGTCGGTGAACCACCAGGGGCTGTCGGCGGCATCCACTATCTCCTTTAACCTGCCCACCGGCCGCTCGCTGTCGGAAGCCAGCGAGGCCATTGACCGCGCGATGACCCAGCTCGGGGTGCCGTCGAGCGTGCGCGGCTCCTTTGCCGGTACCGCTCACGTGTTCCAGCAGACCATGAACGCGCAGGTGATCCTGATCCTCGCGGCTATCGCCACGGTCTATATCGTGCTGGGGGTGCTATATGAGAGCTATGTGCATCCGTTGACCATCCTCTCGACGCTGCCCTCCGCCGGGGTGGGCGCTCTGCTGGCGCTGGAGATCTTCGATGCCCCGTTCAGCCTAATCGCCCTGATTGGGATTATGTTATTAATTGGCATCGTTAAGAAAAACGCCATCATGATGGTTGATTTTGCCCTGGAGGCGCAGCGCAACGGCAACCTGACGCCGGAAGAGGCGATTTTCCAGGCCTGCCTGCTGCGTTTCCGGCCGATTATGATGACCACCCTCGCCGCGCTGTTCGGCGCCCTGCCGCTGGTGCTCTCCGGGGGCGATGGCTCTGAGCTGCGCCAGCCGCTGGGGATCACCATCGTCGGCGGTCTGGTGATGAGCCAGCTGTTAACGCTCTACACCACGCCGGTGGTCTATCTTTTCTTTGACCGTCTGCGGCTGCGTTTTTCGCGTCACTCCTCTCAACCGGTAAGCGAATAA", "orf_prot_sequence": "MKFFALFIYRPVATILISLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVDLNPQALFNQGVSLDAVRTAISDANVRKPQGALEDSAHRWQVQTNDELKTAADYQPLIVHYQNGAAVRLGDVATVSDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRARLPELQQTIPAAIDLQIAQDRSPTIRASLEEVEQTLVISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGSREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLAVSLTLTPMMCGWLLKSGKPHQPTRNRGFGRLLVAMQGGYGKSLKWVLKHSRLTGLVVLGTIVLSVWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIREDPAVDNVTGFTGGSRVNSGMMFITLKPRDQRHETAQQVIDRLRKKLANEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLSALREWEPKIRKALAALPELADVNSDQQDNGAEMDLVYDRDTMSRLGISVQDANNLLNNAFGQRQISTIYQPLNQYKVVMEVDPAYTQDVSALDKMFVINSDGKPIPLAYFAKWQPANAPLSVNHQGLSAASTISFNLPTGRSLSEASEAIDRAMTQLGVPSSVRGSFAGTAHVFQQTMNAQVILILAAIATVYIVLGVLYESYVHPLTILSTLPSAGVGALLALEIFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTPEEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRHSSQPVSE", "perc_identity": 91.41}}, "NODE_3_length_454317_cov_40.2449_18 # 26745 # 27467 # 1 # ID=3_18;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.611": {"gnl|BL_ORD_ID|1258|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 26745, "orf_end": 27467, "orf_from": "NODE_3_length_454317_cov_40.2449_18", "model_name": "baeR", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1337", "pass_evalue": "n/a", "pass_bitscore": "450", "ARO_accession": "3000828", "ARO_name": "baeR", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.2562e-165, "bit_score": 454.136, "max_identities": 218, "cvterm_id": "36839", "query": "MTELPVDENTPRILIVEDEPKLGQLLIDYLQAAGYAPALINHGDKVLPYVRQSPPHLILLDLMLPGTDGLTLCREIRRFSDVPVVMVTAKIEEIDRLLGLEIGADDYVCKPYSPREVVARVKTILRRCKPQRDLQALDAQSPLIVDEGRFQASWRDKLLDLTPAEFRLLKTLSQEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLEALDAEQSFIRAVYGVGYRWEADACRLA", "match": "MTELP+DENTPRILIVEDEPKLGQLLIDYL+AA YAP LI+HGD+VLPYVRQ+PP LILLDLMLPGTDGLTLCREIRRFSD+P+VMVTAKIEEIDRLLGLEIGADDY+CKPYSPREVVARVKTILRRCKPQR+LQ  DA+SPLI+DEGRFQASWR K+LDLTPAEFRLLKTLS EPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLE+LDAEQSFIRAVYGVGYRWEADACR+ ", "sequence_from_db": "MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV", "sequence_from_broadstreet": "MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV", "dna_sequence_from_broadstreet": "ATGACCGAGTTACCAATCGACGAAAACACACCGCGTATTTTGATCGTGGAAGATGAACCGAAGCTGGGGCAGTTGCTCATTGATTATCTGCGTGCTGCGAGCTATGCGCCGACGCTTATCAGCCACGGCGATCAGGTACTGCCGTATGTGCGCCAGACACCACCGGATCTGATCCTGTTAGATCTGATGCTCCCTGGCACCGATGGCCTGACGCTGTGCCGGGAAATTCGTCGTTTTTCTGACATTCCGATCGTGATGGTGACGGCAAAAATCGAAGAGATCGATCGCCTGCTGGGGCTGGAGATTGGCGCAGATGATTATATCTGTAAGCCGTACAGCCCACGGGAAGTGGTAGCGCGCGTCAAAACCATTTTGCGCCGTTGCAAACCGCAGCGCGAGTTGCAGCAACAGGATGCTGAAAGCCCGTTGATTATCGACGAAGGTCGTTTTCAGGCTTCATGGCGCGGTAAAATGCTTGACCTGACGCCTGCGGAATTTCGTCTGCTGAAAACGCTCTCTCACGAACCAGGAAAAGTGTTCTCCCGCGAGCAATTGCTCAATCATCTTTATGACGACTACCGCGTAGTAACCGACCGCACCATCGACAGCCACATTAAAAACCTGCGCCGCAAGCTGGAATCTCTCGACGCCGAACAGTCATTTATCCGCGCCGTTTATGGCGTCGGTTACCGCTGGGAAGCCGACGCCTGCCGCATCGTTTAG", "partial": "0", "query_start": 26745, "query_end": 27464, "orf_dna_sequence": "ATGACTGAATTGCCTGTAGATGAAAACACCCCACGCATCCTTATCGTGGAAGATGAACCGAAGCTCGGCCAACTGCTGATTGATTATCTGCAGGCCGCCGGCTATGCGCCTGCGTTGATTAACCACGGCGACAAGGTCCTGCCCTACGTCCGCCAGTCGCCGCCGCACCTGATCCTGCTGGATCTGATGCTGCCCGGTACCGACGGTCTGACGCTGTGCCGGGAAATTCGCCGCTTCTCCGATGTTCCGGTGGTGATGGTGACGGCGAAAATCGAAGAGATCGACCGTTTGCTGGGGCTGGAAATAGGCGCCGACGACTATGTCTGCAAGCCCTACAGCCCGCGGGAAGTGGTCGCCCGGGTAAAAACCATCCTCCGCCGCTGCAAGCCGCAGCGCGATCTGCAGGCGCTGGACGCCCAGAGCCCGCTGATTGTCGACGAAGGTCGTTTTCAGGCCTCCTGGCGCGACAAGCTGCTGGACCTCACTCCCGCCGAGTTCCGGCTGCTGAAAACCCTCTCCCAGGAGCCGGGCAAAGTGTTCTCCCGCGAACAGCTACTCAACCATCTGTATGACGATTATCGGGTAGTCACCGATCGCACCATCGACAGCCACATCAAGAACCTGCGGCGCAAGCTGGAGGCGCTGGACGCCGAGCAGTCGTTTATCCGCGCGGTGTATGGCGTTGGCTACCGCTGGGAAGCGGACGCCTGCCGGCTGGCGTAG", "orf_prot_sequence": "MTELPVDENTPRILIVEDEPKLGQLLIDYLQAAGYAPALINHGDKVLPYVRQSPPHLILLDLMLPGTDGLTLCREIRRFSDVPVVMVTAKIEEIDRLLGLEIGADDYVCKPYSPREVVARVKTILRRCKPQRDLQALDAQSPLIVDEGRFQASWRDKLLDLTPAEFRLLKTLSQEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLEALDAEQSFIRAVYGVGYRWEADACRLA", "perc_identity": 90.83}}, "NODE_3_length_454317_cov_40.2449_285 # 330238 # 333351 # 1 # ID=3_285;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.609": {"gnl|BL_ORD_ID|1341|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 330238, "orf_end": 333351, "orf_from": "NODE_3_length_454317_cov_40.2449_285", "model_name": "acrD", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1427", "pass_evalue": "n/a", "pass_bitscore": "1900", "ARO_accession": "3000491", "ARO_name": "acrD", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1949.48, "max_identities": 943, "cvterm_id": "36839", "query": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPVKPGESHERTGFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGGNGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQLPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVRRRFPLKERPQ", "match": "MANFFIDRPIFAWVLAILLCLTG LAI SLPVEQYPDLAPPNVR+TANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSS TGQA++TLSF AGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILT+AFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNS+QMT KDVTDAI SQNAQIAVGQLGGTPSVDKQALNATIN+QSLLQTPEQFR+ITLRVNQDGSEV LGDVATVEMGAEKYDYLSR+N +PASGLG+KLASGANEMATAE V+NRL+ELAQ+FPHGLEYKVAYETTSFVKASI DVVKTLLEAI LVFLVMYLFLQNFRATLIPTIAVPVVLMGTF+VLYA GYS+NTLTMFAMVLAIGLLVDDAIVVVENVE IMSEEGL+PREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKP+K GE H + GFF WFN+ FNR+A RYE  V KILHRSLRW++IYVLLLGGMVFLFL LPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVV++ E Y+  +EK N+ SVFATVGSGPGGNGQNVARMF+RLKDW +RD +TGTSFAIIERATKAFNQI EARVIASSPPAISGLGSSAGFDMEL+DHAG GHDALMAAR+ LL LA +NP LTRVRHNGLDDSPQLQ+DIDQRKAQALGV+IDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAA YRMLPDDINLWYVRN  G MVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPG+STGTAMD+ME L  QLP GFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANE+N+KG DL  ATL ACRQRLRPILMTSLAFIFGVLPMATSTGAGSG QHAVGTGVMGGMISAT+LAI+FVPLFFVLVRRRFPLK RP+", "sequence_from_db": "MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRVTANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTAKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEVRLGDVATVEMGAEKYDYLSRFNGKPASGLGVKLASGANEMATAELVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSVNTLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPLKKGEHHGQKGFFAWFNQMFNRNAERYEKGVAKILHRSLRWIVIYVLLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEQIEKYYFTHEKDNIMSVFATVGSGPGGNGQNVARMFIRLKDWSERDSKTGTSFAIIERATKAFNQIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAENPELTRVRHNGLDDSPQLQIDIDQRKAQALGVAIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHACRQRLRPILMTSLAFIFGVLPMATSTGAGSGGQHAVGTGVMGGMISATILAIYFVPLFFVLVRRRFPLKPRPE", "sequence_from_broadstreet": "MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRVTANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTAKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEVRLGDVATVEMGAEKYDYLSRFNGKPASGLGVKLASGANEMATAELVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSVNTLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPLKKGEHHGQKGFFAWFNQMFNRNAERYEKGVAKILHRSLRWIVIYVLLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEQIEKYYFTHEKDNIMSVFATVGSGPGGNGQNVARMFIRLKDWSERDSKTGTSFAIIERATKAFNQIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAENPELTRVRHNGLDDSPQLQIDIDQRKAQALGVAIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHACRQRLRPILMTSLAFIFGVLPMATSTGAGSGGQHAVGTGVMGGMISATILAIYFVPLFFVLVRRRFPLKPRPE", "dna_sequence_from_broadstreet": "ATGGCGAATTTCTTTATTGATCGCCCCATTTTTGCCTGGGTGCTGGCAATCCTGTTGTGTCTGACAGGTACCCTGGCGATTTTTTCATTGCCCGTTGAACAATACCCCGATCTCGCGCCACCGAATGTGCGAGTGACCGCTAACTATCCCGGCGCATCGGCCCAGACGCTGGAAAACACCGTGACCCAGGTTATCGAGCAAAATATGACCGGCCTCGATAATCTCATGTATATGTCATCTCAGAGCAGTGGCACCGGTCAGGCATCTGTCACTTTAAGTTTTAAAGCAGGCACCGATCCGGACGAAGCCGTGCAGCAAGTACAAAACCAGCTGCAATCAGCCATGCGAAAGTTACCGCAGGCGGTGCAAAATCAGGGCGTGACGGTGCGTAAAACCGGCGATACCAACATTCTGACCATTGCCTTCGTCTCTACCGATGGTTCGATGGATAAACAGGATATTGCTGATTATGTTGCCAGTAATATTCAGGACCCGTTAAGCCGCGTGAATGGCGTCGGGGATATCGATGCCTATGGTTCGCAATATTCCATGCGTATCTGGCTGGACCCGGCGAAACTCAACAGTTTCCAGATGACGGCTAAAGATGTCACTGATGCCATTGAGTCACAGAACGCGCAGATTGCGGTTGGGCAACTTGGTGGTACACCTTCCGTCGATAAGCAGGCGCTCAACGCCACCATTAACGCCCAGTCACTGCTGCAAACACCAGAACAGTTCCGCGATATCACCTTGCGGGTCAATCAGGACGGCTCAGAGGTAAGGCTGGGCGATGTCGCCACCGTCGAAATGGGGGCGGAGAAATACGATTATCTTAGCCGCTTCAATGGTAAGCCAGCCTCCGGGCTGGGGGTAAAACTGGCCTCCGGCGCTAACGAAATGGCGACAGCGGAGCTGGTGCTCAATCGTCTCGACGAGCTGGCGCAGTATTTCCCGCATGGACTGGAATACAAGGTGGCGTATGAAACCACCTCGTTTGTTAAAGCCTCCATTGAAGACGTGGTGAAAACGCTGCTGGAAGCTATCGCTCTGGTTTTCCTCGTTATGTATCTGTTCCTGCAAAACTTCCGCGCCACGCTGATACCCACTATCGCCGTGCCGGTGGTGTTGATGGGAACCTTCTCCGTACTTTACGCCTTCGGTTACAGCGTCAACACCTTAACCATGTTCGCGATGGTGCTGGCGATCGGTCTGCTGGTGGATGACGCCATCGTGGTGGTGGAAAACGTCGAACGTATTATGAGTGAGGAAGGACTCACTCCTCGCGAAGCCACACGTAAATCGATGGGGCAGATCCAGGGGGCACTGGTCGGGATTGCGATGGTTCTTTCGGCGGTATTTGTACCAATGGCCTTCTTCGGCGGCACCACCGGTGCCATCTATCGCCAGTTCTCTATTACCATTGTTGCGGCGATGGTGCTGTCAGTACTGGTAGCGATGATCCTCACTCCGGCTCTGTGTGCCACACTACTTAAGCCACTGAAAAAAGGTGAGCATCATGGGCAAAAAGGCTTTTTTGCCTGGTTTAACCAGATGTTTAACCGCAACGCCGAACGCTACGAAAAAGGGGTGGCGAAAATTCTCCACCGTAGCCTGCGCTGGATTGTGATTTATGTCCTGCTGCTTGGCGGCATGGTGTTCCTGTTCCTGCGTTTGCCGACGTCGTTCTTACCGCTGGAAGACCGTGGCATGTTTACTACCTCGGTACAGTTGCCCAGCGGTTCAACGCAACAACAGACCCTGAAAGTCGTTGAGCAAATCGAGAAATACTACTTCACCCATGAAAAAGACAACATCATGTCGGTGTTTGCCACCGTTGGTTCTGGCCCTGGGGGTAACGGGCAAAACGTGGCGCGAATGTTTATCCGCCTGAAAGACTGGAGCGAACGCGACAGTAAGACCGGCACCTCGTTTGCCATTATCGAGCGTGCAACGAAGGCGTTTAACCAAATTAAAGAAGCTCGCGTTATCGCCAGCAGCCCGCCAGCAATTAGCGGTCTTGGTAGTTCTGCAGGTTTTGATATGGAGTTGCAGGACCACGCTGGAGCGGGTCACGATGCGCTGATGGCAGCACGTAATCAGTTGCTGGCGCTGGCGGCGGAAAACCCGGAGCTAACCCGTGTGCGCCATAACGGCCTCGACGACAGTCCGCAGTTGCAGATTGATATCGACCAGCGTAAAGCTCAGGCGCTGGGCGTTGCTATCGACGATATTAACGACACACTGCAAACCGCCTGGGGTTCGAGCTATGTGAATGACTTTATGGATCGCGGTCGCGTGAAGAAAGTCTATGTGCAGGCAGCTGCGCCGTATCGCATGCTGCCAGATGACATCAATCTCTGGTATGTCCGAAATAAAGATGGCGGCATGGTGCCCTTCTCTGCTTTCGCGACCTCACGCTGGGAAACAGGCTCGCCGCGTCTGGAACGCTATAACGGTTATTCTGCGGTTGAGATTGTTGGGGAAGCCGCACCGGGGGTCAGTACCGGTACGGCGATGGATATTATGGAATCGTTAGTGAAGCAGCTGCCAAACGGCTTTGGTCTGGAGTGGACGGCGATGTCGTATCAGGAGCGGCTTTCCGGCGCGCAGGCTCCGGCGCTGTACGCCATTTCCTTGCTGGTGGTATTCCTGTGTCTGGCTGCGTTGTATGAAAGCTGGTCGGTGCCGTTCTCGGTAATGCTGGTCGTGCCGCTGGGGGTAATCGGCGCGCTGCTGGCAACCTGGATGCGCGGGCTGGAAAACGACGTTTACTTCCAGGTGGGCCTGTTAACGGTCATTGGTTTATCGGCGAAAAACGCCATCCTGATCGTCGAGTTTGCTAACGAGATGAACCAAAAAGGCCACGACCTGTTTGAAGCGACGCTCCACGCCTGCCGTCAGCGTTTACGCCCGATTCTGATGACCTCGCTGGCATTTATCTTCGGCGTATTGCCAATGGCAACCAGCACGGGTGCCGGTTCCGGTGGTCAGCATGCGGTGGGTACTGGCGTAATGGGCGGGATGATTTCGGCCACTATTCTGGCTATTTACTTCGTGCCGCTGTTCTTTGTGCTGGTGCGCCGCCGCTTCCCGCTGAAGCCGCGCCCGGAATAA", "partial": "0", "query_start": 330238, "query_end": 333348, "orf_dna_sequence": "ATGGCGAATTTCTTTATCGATCGCCCCATTTTTGCATGGGTGCTGGCAATCCTGTTATGCCTGACGGGCGCCCTTGCCATTTTGTCGCTGCCGGTTGAACAGTATCCCGACCTCGCCCCGCCGAATGTGCGGATCACCGCCAACTATCCCGGCGCCTCCGCGCAAACCCTGGAGAATACCGTCACTCAGGTTATCGAACAGAATATGACCGGCCTCGATAACCTGATGTATATGTCCTCCCAGAGCAGCGCCACCGGCCAGGCGACGATCACCCTCAGCTTTACCGCCGGTACCGACCCGGATGAAGCCGTGCAGCAGGTTCAGAACCAGCTACAGTCGGCGATGCGTAAGCTGCCGCAGGCGGTGCAAAACCAGGGGGTGACGGTGCGCAAGACCGGTGATACCAATATCCTGACGCTCGCCTTCGTCTCCACTGACGGCAGTATGGATAAACAAGATATCGCCGACTACGTCGCCAGTAACATCCAGGACCCGCTCAGCCGCGTCAACGGCGTGGGGGATATCGACGCCTACGGTTCGCAATACTCAATGCGCATCTGGCTCGACCCGGCGAAGCTCAACAGCTACCAGATGACCACCAAGGATGTTACCGACGCCATCAGTTCGCAGAACGCCCAGATTGCCGTCGGCCAGCTTGGCGGGACGCCTTCGGTCGATAAGCAAGCGCTGAACGCCACCATCAACTCGCAATCTCTGCTGCAAACCCCGGAGCAGTTCCGCAATATCACTCTGCGCGTCAATCAGGATGGTTCAGAGGTGACGCTGGGCGATGTCGCCACCGTCGAGATGGGGGCGGAGAAGTACGACTATCTTAGCCGCTACAACCGCCAGCCGGCCTCAGGCCTCGGGATCAAGCTGGCTTCCGGCGCCAACGAAATGGCCACCGCGGAGCGCGTGATCAATCGCCTCAATGAGCTGGCGCAGTTTTTCCCCCACGGTCTGGAATATAAGGTCGCCTACGAGACCACCTCCTTCGTGAAGGCTTCCATCACCGACGTGGTGAAAACCCTGCTGGAGGCAATCCTGCTGGTCTTCCTCGTGATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCGACCATCGCCGTGCCGGTGGTGCTGATGGGCACTTTCGCGGTGCTGTATGCCTGTGGTTACAGCATTAACACCCTGACGATGTTCGCGATGGTGTTGGCGATCGGCCTGCTGGTGGATGACGCCATCGTGGTGGTGGAGAACGTCGAGCACATCATGAGCGAGGAGGGCCTGTCGCCACGCGAGGCGACCCGCAAATCGATGGGACAAATTCAGGGCGCGCTGGTAGGGATCGCGATGGTGCTGTCGGCGGTATTTGTGCCGATGGCCTTCTTCGGCGGCACCACCGGCGCCATCTATCGCCAGTTCTCAATCACTATCGTCGCGGCGATGGTCCTCTCGGTGCTGGTGGCCATGATCCTCACCCCTGCCCTTTGCGCCACGCTGCTTAAGCCGGTTAAGCCAGGTGAATCCCATGAAAGAACAGGCTTCTTCGGCTGGTTCAACCGCACCTTCAACCGCAGCGCCAGCCGCTACGAAACCTTCGTCGGCAAAATCCTGCACCGCTCGCTGCGCTGGATGCTGATCTACGTCCTCCTGCTCGGCGGGATGGTGTTCCTGTTTCTGCATTTGCCGACCTCGTTCCTGCCGCTGGAGGATCGCGGGATGTTCACCACCTCGGTCCAGTTGCCGAGCGGCAGCACCCAGCAGCAGACGCTGAAGGTGGTGCAGAAGGCGGAAGATTACTTTCTCAATAACGAGAAGCAGAACGTCGAGTCGGTGTTCGCTACCGTTGGCTCCGGCCCCGGCGGCAATGGGCAGAACGTGGCCCGCATGTTCGTTCGTCTCAAAGACTGGGACCAGCGCGACCCGCAAACCGGCACCTCCTTTGCCATTATTGAACGCGCCACCAAAGCGTTTAATCAGATTAACGAAGCGCGGGTTATCGCCAGCAGCCCGCCGGCGATCAGCGGCCTCGGCAGTTCGGCAGGCTTCGATATGGAGCTGGAGGATCATGCCGGGAAGGGGCACGATGCGCTGATGGCGGCGCGCGATACGCTGCTTGAGCTGGCCGGGAAAAATCCGCTGTTGACCCGCGTCCGGCATAACGGGCTCGATGACAGTCCGCAGCTGCAGGTCGATATCGATCAGCGTAAAGCGCAGGCGCTGGGCGTCTCCATTGACGACATCAACGATACGCTGCAAACCGCGTGGGGGTCGAGCTACGTCAACGACTTTATGGATCGCGGCCGGGTAAAGAAAGTCTACGTCCAGGCGGCGGCGAAATACCGGATGCTGCCTGACGATATCAATCTTTGGTACGTGCGCAACAGCAGCGGCACGATGGTGCCATTCTCGGCCTTCGCCACCTCGCGCTGGGAGACCGGCTCGCCGCGGCTGGAGCGCTACAATGGCTACTCAGCGGTCGAGATCGTCGGTGAGGCGGCGCCGGGTATCAGTACCGGTACCGCGATGGACATGATGGAGAAGCTGGCCGCGCAGTTACCCACCGGCTTTGGCCTCGAATGGACCGCCATGTCCTACCAGGAACGCCTCTCTGGCGCTCAGGCGCCGGCCCTGTATGCTATTTCTCTGCTGGTGGTGTTCCTGTGCCTGGCGGCGCTGTACGAGAGCTGGTCGGTGCCGTTCTCGGTGATGCTGGTGGTGCCGCTGGGGGTGATTGGCGCCCTGCTGGCGACCTGGATGCGCGGTCTGGAGAATGACGTGTACTTCCAGGTGGGTCTGTTGACGGTGATCGGCCTGTCGGCGAAAAACGCCATTCTGATCGTCGAGTTCGCCAATGAGCTCAACGAGAAGGGCCAGGATCTGCTCAGCGCCACGCTGTCGGCTTGCCGTCAGCGCCTGCGCCCCATCCTGATGACCTCGCTGGCGTTCATCTTCGGCGTGCTGCCGATGGCGACCAGCACCGGCGCCGGTTCCGGCAGCCAGCATGCGGTCGGCACCGGAGTGATGGGCGGGATGATCTCCGCCACCGTGCTGGCGATCTTTTTCGTGCCGCTGTTCTTTGTGCTGGTGCGTCGCCGTTTTCCGCTAAAGGAGCGTCCGCAATAA", "orf_prot_sequence": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPVKPGESHERTGFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGGNGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQLPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVRRRFPLKERPQ", "perc_identity": 90.94}, "gnl|BL_ORD_ID|137|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 330238, "orf_end": 333351, "orf_from": "NODE_3_length_454317_cov_40.2449_285", "model_name": "adeF", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "153", "pass_evalue": "n/a", "pass_bitscore": "750", "ARO_accession": "3000777", "ARO_name": "adeF", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 752.666, "max_identities": 433, "cvterm_id": "35535", "query": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGS-QYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLK--PVKPGESHERT------GFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGG--NGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQ-LPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVR", "match": "++ FFIDRPIFA VL++L+ L G L++  LP+ +YP++ PP+V + A YPGA+ + +  TV   +E+++ G+++++YM SQ+++ G  TIT++F  G DPD+A Q VQN++  AM +LP+ VQ  GVT  K+  T  + +   S D   D   + +Y   N++D L+R+ GVG++  +GS  Y+MR+WLDP K+    +T  ++ +AI  QN Q+A G +G +PS     L  ++N+Q  L T ++F +I L+   DG+   LGDVA VE+ A +Y   S  + + A  + I  A GAN +  +++V + + EL++ FP  ++Y + Y+ T FV+ASI  VV TLLEAI LV +V+ LFLQ +RA++IP +AVPV ++GTFA++ A GYSIN L++F MVLAIG++VDDAIVVVENVE  + E GL+PREAT ++M ++ G ++ IA+ L AVFVP+AF  G TG  Y+QF++TI  + V+S   ++ L+PAL A LLK    KP ++  R        FF  FNR F+R++ RY   V +++      M +Y  LLG  V +   +P  F+P +D+    +  QLP+G++  +T  V++K  D  L  ++  VES  A  G    G  N  +   +FV LK +D+R  +  ++ AI     + ++ I +A +    PP + GLG+  GF ++LED    G+ AL  A    ++ A   P L  +  +   + PQL VD+D+ KA+  GV++ D+ +T+Q   GS YVNDF   GRV +V  QA A +R  P+DI     RNS+G MVP S+        G   + RYNGY++ +I G  APG S+  A   +E++AAQ LP G   EWT ++YQ+ L+G     ++ IS+L+VFL LAA YES ++P +V+L+VP+G++ AL   W+   +N+++ Q+GL+ ++GL+ KNAILIVEFA EL  +G     A + A R RLRPILMTS+AFI GV+P+ TSTGAGS  +HA+G  V  GMI  T   +F  P F+VL+R", "sequence_from_db": "ISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPS--NSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNI-EAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKP-DALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTAL--KQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIR", "sequence_from_broadstreet": "MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPSNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHKLHSAAVHEAPLASPHDH", "dna_sequence_from_broadstreet": "ATGAATATTTCTAAATTTTTTATTGATCGGCCGATCTTTGCTGGTGTGCTATCAGTCTTGATTTTACTCGCCGGTCTCCTTTCGGTATTTCAGTTACCGATTTCTGAATATCCCGAGGTTGTTCCACCATCTGTGGTGGTACGCGCCCAATATCCGGGTGCAAACCCAAAAGTGATTGCTGAAACGGTTGCATCTCCGCTCGAAGAGTCAATCAACGGCGTCGAAGACATGCTGTATATGCAATCTCAAGCAAACAGCGACGGTAACCTAACCATTACGGTGAACTTTAAGCTCGGTATCGACCCAGACAAAGCCCAACAATTGGTTCAAAACCGTGTGTCTCAGGCCATGCCCCGTTTACCTGAAGATGTACAGCGCTTAGGTGTAACCACACTAAAAAGCTCACCTACTTTAACTATGGTAGTGCATCTGACCTCACCAGATAATCGCTATGACATGACCTACTTACGTAACTATGCGGTGCTCAACGTGAAAGACCGTTTAGCGCGTTTACAAGGGGTTGGTGAAGTCGGATTATTTGGTTCTGGTGACTACGCGATGCGTGTATGGCTTGACCCGCAAAAAGTAGCGCAGCGTAACCTCACCGCGACCGAAATTGTGAATGCAATCCGTGAACAAAATATTCAGGTTGCAGCGGGTACAATCGGTGCATCACCAAGTAATTCACCTTTACAGCTTTCAGTCAATGCTCAAGGTCGTTTAACTACTGAACAAGAATTCGCAGATATCATTTTAAAAACTGCACCAGATGGCGCGGTTACCCGATTGGGTGATGTTGCTCGTGTCGAACTTGCAGCCTCTCAATATGGCTTACGTTCATTGCTTGATAATAAACAAGCGGTCGCGATTCCAATTTTCCAAGCACCGGGTGCGAATGCTTTACAAGTTTCCGATCAAGTGCGTAGCACAATGAAGGAGCTTTCAAAAGATTTCCCATCTTCAATTAAATACGACATTGTTTATGACCCGACTCAATTCGTACGTGCAAGTATTAAAGCGGTCGTTCATACCTTACTTGAAGCAATTACACTGGTTGTTGTGGTCGTTATTTTATTCTTGCAAACATGGCGTGCCTCAATCATTCCATTGCTTGCCGTACCGGTTTCAATTATTGGTACATTCGCGCTCATGCTCGCTTTTGGTTACTCAATCAATGCGCTATCACTGTTCGGAATGGTACTTGCCATCGGGATTGTCGTCGATGACGCGATTGTGGTCGTCGAAAATGTCGAGAGGAATATTGAAGCAGGCTTAAACCCAAGGGAGGCGACTTACCGTGCCATGCGAGAAGTCAGTGGACCGATTATTGCCATTGCTTTAACACTTGTTGCAGTATTCGTACCTCTTGCCTTTATGACAGGCTTAACAGGGCAATTCTATAAACAATTTGCCATGACCATTGCCATTTCAACGGTTATTTCGGCATTTAACTCGCTTACCCTATCTCCTGCTTTGGCAGCGCTGTTACTGAAAGGACATGATGCTAAACCGGATGCCTTAACACGTATTATGAATCGTGTATTCGGTCGTTTCTTTGCACTGTTTAACCGTGTGTTTTCACGTGCTTCAGACCGTTATAGTCAAGGCGTCAGCCGTGTCATTTCCCATAAAGCTTCGGCAATGGGTGTCTATGCAGCACTCTTAGGTTTAACCGTTGGTATTTCCTATATTGTTCCAGGTGGTTTCGTTCCTGCGCAGGACAAACAATATTTAATTAGCTTTGCGCAGCTACCAAACGGCGCATCATTAGATCGTACCGAAGCGGTCATTCGTAAAATGAGTGACACTGCACTTAAACAACCTGGTGTAGAAAGTGCAGTTGCCTTTCCTGGCCTATCAATTAACGGTTTCACCAATAGCTCAAGTGCCGGTATTGTCTTTGTGACTTTAAAGCCATTTGATGAACGTAAGGCAAAAGACTTATCTGCAAATGCAATTGCAGGTGCGCTCAACCAGAAATATTCAGCTATTCAAGATGCCTATATCGCGGTTTTCCCACCGCCACCAGTGATGGGCTTAGGTACTATGGGCGGCTTTAAACTACAACTTGAAGACCGAGGTGCCTTAGGCTATTCAGCCTTGAACGATGCTGCACAAAACTTTATGAAGGCAGCACAATCAGCCCCTGAACTGGGTCCAATGTTCTCAAGTTATCAAATTAACGTACCTCAACTCAACGTAGATCTGGACCGTGTAAAAGCTAAACAGCAAGGCGTTGCTGTGACAGATGTTTTCAATACTATGCAGATTTATTTAGGTTCTCAGTACGTTAACGACTTTAACCGCTTTGGACGTGTTTATCAGGTTCGTGCACAAGCCGATGCGCCTTTCCGTGCTAACCCTGAAGATATTTTGCAGCTTAAAACCCGTAATAGTGCCGGACAAATGGTGCCATTATCTTCATTGGTGAATGTAACTCAAACCTATGGTCCTGAAATGGTCGTTCGTTATAACGGTTACACATCAGCAGATATTAACGGTGGCCCTGCCCCAGGTTATTCATCTAGCCAAGCAGAAGCTGCGGTTGAACGTATTGCTGCACAAACTCTACCGCGTGGTATCAAGTTTGAATGGACAGATTTAACTTATCAAAAAATCTTGGCTGGTAATGCTGGACTTTGGGTATTCCCTATTAGCGTATTACTCGTGTTCTTAGTGTTAGCTGCTCAGTATGAAAGCTTAACCCTACCATTAGCAGTTATCTTAATTGTACCAATGGGAATCTTAGCGGCTCTGACAGGTGTCTGGTTGACAGCTGGAGATAACAACATCTTTACTCAAATCGGTCTAATGGTACTGGTCGGGCTAGCCTGTAAAAATGCCATCTTAATTGTCGAATTTGCGAGGGAACTTGAAATGCAAGGTGCGACTGCCTTTAAAGCAGCCGTTGAAGCAAGTCGTCTACGTTTACGCCCAATTTTAATGACCTCTATTGCATTTATTATGGGTGTAGTGCCACTGGTTACTTCAACTGGCGCAGGTTCTGAAATGCGACATGCGATGGGTGTTGCCGTATTCTTCGGTATGATCGGTGTAACATTCTTTGGTTTATTCCTCACCCCGGCCTTTTACGTTCTGATTCGTACCCTCAACAGCAAACATAAACTGCATTCTGCGGCAGTTCATGAAGCGCCGTTAGCTAGCCCACATGATCATTAA", "partial": "0", "query_start": 330238, "query_end": 333318, "orf_dna_sequence": "ATGGCGAATTTCTTTATCGATCGCCCCATTTTTGCATGGGTGCTGGCAATCCTGTTATGCCTGACGGGCGCCCTTGCCATTTTGTCGCTGCCGGTTGAACAGTATCCCGACCTCGCCCCGCCGAATGTGCGGATCACCGCCAACTATCCCGGCGCCTCCGCGCAAACCCTGGAGAATACCGTCACTCAGGTTATCGAACAGAATATGACCGGCCTCGATAACCTGATGTATATGTCCTCCCAGAGCAGCGCCACCGGCCAGGCGACGATCACCCTCAGCTTTACCGCCGGTACCGACCCGGATGAAGCCGTGCAGCAGGTTCAGAACCAGCTACAGTCGGCGATGCGTAAGCTGCCGCAGGCGGTGCAAAACCAGGGGGTGACGGTGCGCAAGACCGGTGATACCAATATCCTGACGCTCGCCTTCGTCTCCACTGACGGCAGTATGGATAAACAAGATATCGCCGACTACGTCGCCAGTAACATCCAGGACCCGCTCAGCCGCGTCAACGGCGTGGGGGATATCGACGCCTACGGTTCGCAATACTCAATGCGCATCTGGCTCGACCCGGCGAAGCTCAACAGCTACCAGATGACCACCAAGGATGTTACCGACGCCATCAGTTCGCAGAACGCCCAGATTGCCGTCGGCCAGCTTGGCGGGACGCCTTCGGTCGATAAGCAAGCGCTGAACGCCACCATCAACTCGCAATCTCTGCTGCAAACCCCGGAGCAGTTCCGCAATATCACTCTGCGCGTCAATCAGGATGGTTCAGAGGTGACGCTGGGCGATGTCGCCACCGTCGAGATGGGGGCGGAGAAGTACGACTATCTTAGCCGCTACAACCGCCAGCCGGCCTCAGGCCTCGGGATCAAGCTGGCTTCCGGCGCCAACGAAATGGCCACCGCGGAGCGCGTGATCAATCGCCTCAATGAGCTGGCGCAGTTTTTCCCCCACGGTCTGGAATATAAGGTCGCCTACGAGACCACCTCCTTCGTGAAGGCTTCCATCACCGACGTGGTGAAAACCCTGCTGGAGGCAATCCTGCTGGTCTTCCTCGTGATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCGACCATCGCCGTGCCGGTGGTGCTGATGGGCACTTTCGCGGTGCTGTATGCCTGTGGTTACAGCATTAACACCCTGACGATGTTCGCGATGGTGTTGGCGATCGGCCTGCTGGTGGATGACGCCATCGTGGTGGTGGAGAACGTCGAGCACATCATGAGCGAGGAGGGCCTGTCGCCACGCGAGGCGACCCGCAAATCGATGGGACAAATTCAGGGCGCGCTGGTAGGGATCGCGATGGTGCTGTCGGCGGTATTTGTGCCGATGGCCTTCTTCGGCGGCACCACCGGCGCCATCTATCGCCAGTTCTCAATCACTATCGTCGCGGCGATGGTCCTCTCGGTGCTGGTGGCCATGATCCTCACCCCTGCCCTTTGCGCCACGCTGCTTAAGCCGGTTAAGCCAGGTGAATCCCATGAAAGAACAGGCTTCTTCGGCTGGTTCAACCGCACCTTCAACCGCAGCGCCAGCCGCTACGAAACCTTCGTCGGCAAAATCCTGCACCGCTCGCTGCGCTGGATGCTGATCTACGTCCTCCTGCTCGGCGGGATGGTGTTCCTGTTTCTGCATTTGCCGACCTCGTTCCTGCCGCTGGAGGATCGCGGGATGTTCACCACCTCGGTCCAGTTGCCGAGCGGCAGCACCCAGCAGCAGACGCTGAAGGTGGTGCAGAAGGCGGAAGATTACTTTCTCAATAACGAGAAGCAGAACGTCGAGTCGGTGTTCGCTACCGTTGGCTCCGGCCCCGGCGGCAATGGGCAGAACGTGGCCCGCATGTTCGTTCGTCTCAAAGACTGGGACCAGCGCGACCCGCAAACCGGCACCTCCTTTGCCATTATTGAACGCGCCACCAAAGCGTTTAATCAGATTAACGAAGCGCGGGTTATCGCCAGCAGCCCGCCGGCGATCAGCGGCCTCGGCAGTTCGGCAGGCTTCGATATGGAGCTGGAGGATCATGCCGGGAAGGGGCACGATGCGCTGATGGCGGCGCGCGATACGCTGCTTGAGCTGGCCGGGAAAAATCCGCTGTTGACCCGCGTCCGGCATAACGGGCTCGATGACAGTCCGCAGCTGCAGGTCGATATCGATCAGCGTAAAGCGCAGGCGCTGGGCGTCTCCATTGACGACATCAACGATACGCTGCAAACCGCGTGGGGGTCGAGCTACGTCAACGACTTTATGGATCGCGGCCGGGTAAAGAAAGTCTACGTCCAGGCGGCGGCGAAATACCGGATGCTGCCTGACGATATCAATCTTTGGTACGTGCGCAACAGCAGCGGCACGATGGTGCCATTCTCGGCCTTCGCCACCTCGCGCTGGGAGACCGGCTCGCCGCGGCTGGAGCGCTACAATGGCTACTCAGCGGTCGAGATCGTCGGTGAGGCGGCGCCGGGTATCAGTACCGGTACCGCGATGGACATGATGGAGAAGCTGGCCGCGCAGTTACCCACCGGCTTTGGCCTCGAATGGACCGCCATGTCCTACCAGGAACGCCTCTCTGGCGCTCAGGCGCCGGCCCTGTATGCTATTTCTCTGCTGGTGGTGTTCCTGTGCCTGGCGGCGCTGTACGAGAGCTGGTCGGTGCCGTTCTCGGTGATGCTGGTGGTGCCGCTGGGGGTGATTGGCGCCCTGCTGGCGACCTGGATGCGCGGTCTGGAGAATGACGTGTACTTCCAGGTGGGTCTGTTGACGGTGATCGGCCTGTCGGCGAAAAACGCCATTCTGATCGTCGAGTTCGCCAATGAGCTCAACGAGAAGGGCCAGGATCTGCTCAGCGCCACGCTGTCGGCTTGCCGTCAGCGCCTGCGCCCCATCCTGATGACCTCGCTGGCGTTCATCTTCGGCGTGCTGCCGATGGCGACCAGCACCGGCGCCGGTTCCGGCAGCCAGCATGCGGTCGGCACCGGAGTGATGGGCGGGATGATCTCCGCCACCGTGCTGGCGATCTTTTTCGTGCCGCTGTTCTTTGTGCTGGTGCGTCGCCGTTTTCCGCTAAAGGAGCGTCCGCAATAA", "orf_prot_sequence": "MANFFIDRPIFAWVLAILLCLTGALAILSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSATGQATITLSFTAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTLAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSYQMTTKDVTDAISSQNAQIAVGQLGGTPSVDKQALNATINSQSLLQTPEQFRNITLRVNQDGSEVTLGDVATVEMGAEKYDYLSRYNRQPASGLGIKLASGANEMATAERVINRLNELAQFFPHGLEYKVAYETTSFVKASITDVVKTLLEAILLVFLVMYLFLQNFRATLIPTIAVPVVLMGTFAVLYACGYSINTLTMFAMVLAIGLLVDDAIVVVENVEHIMSEEGLSPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVAAMVLSVLVAMILTPALCATLLKPVKPGESHERTGFFGWFNRTFNRSASRYETFVGKILHRSLRWMLIYVLLLGGMVFLFLHLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVQKAEDYFLNNEKQNVESVFATVGSGPGGNGQNVARMFVRLKDWDQRDPQTGTSFAIIERATKAFNQINEARVIASSPPAISGLGSSAGFDMELEDHAGKGHDALMAARDTLLELAGKNPLLTRVRHNGLDDSPQLQVDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAKYRMLPDDINLWYVRNSSGTMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGISTGTAMDMMEKLAAQLPTGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANELNEKGQDLLSATLSACRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATVLAIFFVPLFFVLVRRRFPLKERPQ", "perc_identity": 41.67}}, "NODE_4_length_367278_cov_42.3139_12 # 14037 # 14456 # 1 # ID=4_12;partial=00;start_type=ATG;rbs_motif=GGAGG;rbs_spacer=5-10bp;gc_cont=0.614": {"gnl|BL_ORD_ID|2472|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA6", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2779", "pass_evalue": "n/a", "pass_bitscore": "280", "ARO_accession": "3004111", "ARO_name": "FosA6", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.20667e-101, "bit_score": 283.108, "max_identities": 136, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "match": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVA+WKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQ YKGMVFF+Q", "sequence_from_db": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAIWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQQYKGMVFFDQ", "sequence_from_broadstreet": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAIWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQQYKGMVFFDQ", "dna_sequence_from_broadstreet": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGATCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGTCTGGCCGCCTGCCGCGAACAGCAGTATAAGGGGATGGTGTTTTTTGATCAGTGA", "partial": "0", "query_start": 14037, "query_end": 14453, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 97.84}, "gnl|BL_ORD_ID|98|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA5", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "112", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3003209", "ARO_name": "FosA5", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.79735e-101, "bit_score": 282.337, "max_identities": 136, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "match": "MLSGLNHLTLAVSQLAPSVAFYQQLLGM LHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFF +", "sequence_from_db": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMMLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFAE", "sequence_from_broadstreet": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMMLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFAE", "dna_sequence_from_broadstreet": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGATGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATCTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTAGCGGTCTGGAAGCTGAACCGTAGCGAAGGCGCTTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGTCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGCTGAGTGA", "partial": "0", "query_start": 14037, "query_end": 14453, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 97.84}, "gnl|BL_ORD_ID|786|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA3", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "834", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3002872", "ARO_name": "FosA3", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.2005e-80, "bit_score": 229.18, "max_identities": 110, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFE", "match": "ML GLNHLTLAVS LA S+AFYQQL GM LHA WDSGAYLSCG LWLCLSLD QRR TPP+ESDYTHYAFS++E +FA   A L  AG  VWK NRSEGAS+YFLDPDGHKLELHVG+LAQRLAACRE+PYKGMVFF+", "sequence_from_db": "MLQGLNHLTLAVSDLASSLAFYQQLPGMRLHASWDSGAYLSCGALWLCLSLDEQRRKTPPQESDYTHYAFSVAEEEFAGVVALLAQAGAEVWKDNRSEGASYYFLDPDGHKLELHVGNLAQRLAACRERPYKGMVFFD", "sequence_from_broadstreet": "MLQGLNHLTLAVSDLASSLAFYQQLPGMRLHASWDSGAYLSCGALWLCLSLDEQRRKTPPQESDYTHYAFSVAEEEFAGVVALLAQAGAEVWKDNRSEGASYYFLDPDGHKLELHVGNLAQRLAACRERPYKGMVFFD", "dna_sequence_from_broadstreet": "ATGCTGCAGGGATTGAATCATCTGACGCTGGCGGTCAGCGATCTGGCGTCAAGCCTGGCATTTTATCAGCAGTTACCTGGAATGCGCCTGCACGCCAGCTGGGATAGCGGAGCCTATCTCTCCTGTGGGGCGCTGTGGCTGTGCTTGTCGCTGGATGAGCAGCGGCGTAAAACGCCCCCTCAGGAAAGCGACTATACCCACTACGCCTTCAGCGTGGCGGAAGAAGAGTTTGCCGGGGTGGTGGCTCTGCTGGCGCAGGCGGGGGCTGAGGTATGGAAAGATAACCGCAGTGAAGGGGCGTCTTACTATTTTCTCGACCCTGACGGCCATAAGCTGGAGCTGCATGTGGGGAATCTGGCGCAGCGGCTGGCCGCCTGTCGCGAACGCCCCTACAAGGGGATGGTCTTTTTTGATTGA", "partial": "0", "query_start": 14037, "query_end": 14450, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 79.71}, "gnl|BL_ORD_ID|1869|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA4", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1979", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3003210", "ARO_name": "FosA4", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.42796e-78, "bit_score": 225.713, "max_identities": 109, "cvterm_id": "35914", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFE", "match": "ML GLNHLTLAVS LA S+AFYQ+L GM LHARWDSGAYLSCG LWLCLSLD QRR TP +ESDYTHYAFS++E  FA   A+L  AG  VWK NRSEGAS+YFLDPDGHKLELHVG LAQRLAACRE+PYKGMVFF+", "sequence_from_db": "MLQGLNHLTLAVSDLASSLAFYQRLPGMRLHARWDSGAYLSCGALWLCLSLDAQRRKTPAQESDYTHYAFSVAEEHFAEVVAQLAHAGAEVWKDNRSEGASYYFLDPDGHKLELHVGHLAQRLAACRERPYKGMVFFD", "sequence_from_broadstreet": "MLQGLNHLTLAVSDLASSLAFYQRLPGMRLHARWDSGAYLSCGALWLCLSLDAQRRKTPAQESDYTHYAFSVAEEHFAEVVAQLAHAGAEVWKDNRSEGASYYFLDPDGHKLELHVGHLAQRLAACRERPYKGMVFFD", "dna_sequence_from_broadstreet": "ATGCTGCAGGGATTGAATCATCTGACGCTGGCGGTCAGCGATCTGGCGTCAAGCCTGGCGTTTTATCAGCGGTTACCTGGAATGCGTCTGCACGCCCGTTGGGATAGCGGAGCATATCTTTCCTGCGGGGCGTTGTGGCTATGCTTGTCGCTGGATGCGCAGCGGCGTAAAACGCCCGCTCAGGAAAGCGACTATACCCATTATGCTTTCAGCGTGGCGGAAGAGCACTTTGCCGAGGTGGTCGCCCAGCTGGCGCACGCGGGGGCCGAAGTATGGAAAGACAACCGCAGCGAAGGGGCGTCGTACTATTTTCTCGACCCTGACGGCCATAAGCTGGAACTGCATGTGGGTCATTTGGCACAGCGGCTGGCCGCCTGTCGGGAACGCCCGTACAAGGGGATGGTCTTTTTTGACTGA", "partial": "0", "query_start": 14037, "query_end": 14450, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 78.99}, "gnl|BL_ORD_ID|29|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 14037, "orf_end": 14456, "orf_from": "NODE_4_length_367278_cov_42.3139_12", "model_name": "FosA2", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "35", "pass_evalue": "n/a", "pass_bitscore": "200", "ARO_accession": "3002804", "ARO_name": "FosA2", "ARO_category": {"36272": {"category_aro_accession": "3000133", "category_aro_cvterm_id": "36272", "category_aro_name": "fosfomycin thiol transferase", "category_aro_description": "Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.14464e-73, "bit_score": 211.46, "max_identities": 97, "cvterm_id": "36884", "query": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVF", "match": "ML  LNHLTLAVS L  SV F+ +LLG+TLHARW++GAYL+CGDLW+CLS D  R   PP+ESDYTHYAF+++  DF  F+ +LE AGV VWK N+SEGAS YFLDPDGHKLELHVGSLA RLAACRE+PY GMVF", "sequence_from_db": "MLQSLNHLTLAVSDLQKSVTFWHELLGLTLHARWNTGAYLTCGDLWVCLSYDEARGYVPPQESDYTHYAFTVAAEDFEPFSHKLEQAGVTVWKQNKSEGASFYFLDPDGHKLELHVGSLAARLAACREKPYAGMVF", "sequence_from_broadstreet": "MLQSLNHLTLAVSDLQKSVTFWHELLGLTLHARWNTGAYLTCGDLWVCLSYDEARGYVPPQESDYTHYAFTVAAEDFEPFSHKLEQAGVTVWKQNKSEGASFYFLDPDGHKLELHVGSLAARLAACREKPYAGMVFTSDEA", "dna_sequence_from_broadstreet": "ATGCTGCAATCACTCAACCATCTGACCCTCGCGGTCAGCGACCTGCAAAAAAGCGTTACCTTCTGGCACGAGCTGCTGGGGCTGACGCTGCACGCCCGCTGGAATACCGGGGCCTATCTTACCTGCGGCGATCTGTGGGTCTGCCTGTCCTATGACGAGGCGCGCGGTTACGTGCCGCCGCAGGAGAGCGACTATACCCATTACGCGTTTACCGTTGCGGCGGAAGATTTTGAGCCGTTCTCGCACAAGCTGGAGCAGGCGGGCGTTACCGTCTGGAAGCAAAACAAAAGTGAGGGGGCATCGTTCTATTTTCTCGACCCGGACGGGCACAAGCTGGAGCTGCACGTGGGCAGCCTCGCCGCGCGGCTGGCGGCGTGCCGGGAGAAACCCTATGCCGGAATGGTCTTCACCTCAGACGAGGCTTGA", "partial": "0", "query_start": 14037, "query_end": 14444, "orf_dna_sequence": "ATGCTGAGTGGACTGAATCACCTGACCCTGGCAGTCAGCCAGCTGGCGCCGAGCGTGGCGTTTTATCAGCAGCTGCTGGGCATGACGCTGCATGCCCGCTGGGACAGCGGGGCTTATCTCTCCTGCGGCGATTTGTGGCTGTGCCTGTCGCTGGATCCGCAGCGGCGCGTTACTCCGCCGGAAGAGAGCGACTACACCCATTATGCGTTTAGTATTAGCGAAGCCGATTTTGCTAGCTTCGCCGCCCGCCTTGAGGCTGCCGGCGTGGCGGTCTGGAAGCTGAACCGTAGCGAAGGTGCCTCGCACTATTTCCTCGATCCCGATGGCCATAAGCTGGAGCTGCACGTCGGCAGTCTCGCCCAGCGGCTGGCCGCCTGCCGCGAGCAGCCGTATAAGGGGATGGTGTTTTTTGAACAGTGA", "orf_prot_sequence": "MLSGLNHLTLAVSQLAPSVAFYQQLLGMTLHARWDSGAYLSCGDLWLCLSLDPQRRVTPPEESDYTHYAFSISEADFASFAARLEAAGVAVWKLNRSEGASHYFLDPDGHKLELHVGSLAQRLAACREQPYKGMVFFEQ", "perc_identity": 71.32}}, "NODE_6_length_262587_cov_42.4347_106 # 86156 # 87349 # 1 # ID=6_106;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.562": {"gnl|BL_ORD_ID|2388|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Klebsiella pneumoniae acrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "770", "model_id": "2659", "ARO_accession": "3004041", "ARO_name": "Klebsiella pneumoniae acrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 380, "bit_score": 738.028, "cvterm_id": "35915", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPI--SGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "match": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGV LYQIDPATYQ SYDSAKGDLAKAQAAANMDQLTVKRYQKLLGT+YISQQDYD AVATAQQ+NAAVVAAK AVETARINLAYT+  SP+  +   GKS VTEGALVQNGQTTALATVQQ+DPIYVDVTQSSNDFLRLKQELAD RLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "sequence_from_db": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVFLYQIDPATYQGSYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTQYISQQDYDPAVATAQQNNAAVVAAKTAVETARINLAYTQ-KSPLRSAAGSGKSPVTEGALVQNGQTTALATVQQVDPIYVDVTQSSNDFLRLKQELADARLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "sequence_from_broadstreet": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVFLYQIDPATYQGSYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTQYISQQDYDPAVATAQQNNAAVVAAKTAVETARINLAYTQKSPLRSAAGSGKSPVTEGALVQNGQTTALATVQQVDPIYVDVTQSSNDFLRLKQELADARLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "dna_sequence_from_broadstreet": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTTCCTGTATCAGATCGATCCAGCCACCTATCAAGGCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCCAATATATTAGTCAACAAGACTACGATCCCGCCGTTGCGACGGCGCAACAAAACAATGCCGCCGTGGTCGCGGCGAAAACTGCCGTTGAAACCGCGCGCATCAATTTGGCCTACACCCAAAAGTCACCTCTCCGATCAGCGGCCGGATCGGGTAAATCCCCCGTGACCGAAGGGGCGTTGGTACAGAATGGTCAAACGACCGCCTTGGCAACCGTTCAGCAAGTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGCCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTGGTGACTAATGACGGGCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTTCCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGTGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "partial": "0", "query_start": 86156, "query_end": 87346, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 95.24, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2389|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Enterobacter cloacae acrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "760", "model_id": "2660", "ARO_accession": "3004042", "ARO_name": "Enterobacter cloacae acrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 348, "bit_score": 661.759, "cvterm_id": "36884", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "match": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQ  PEVG+VTLKS PLQITTELPGRT+AYRIAEVRPQVSGIILKRNF EG D+QAG SLYQIDPATYQASY+SAKGDLAKAQAAA + QLT+ RYQKLLGTKYISQQDYDTA+A AQQ+NAAVVAAKAAVETARINLAYTKVTSPISGRIGKS+VTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELA+G LKQENGKAKVEL+TNDG+K+PQ GTLEFSDVTVDQTTGSITLRAIFPNPD  LLPGMFVRARLEEG NP ALLVPQQGVTRTPRGDAS +VVG  +KVE+R +TA+QAIGDKWLVT+GLK GDRVIVTGLQK++PG QVKAQEV SDDKQQA+    SEQTKS", "sequence_from_db": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQQAPEVGVVTLKSEPLQITTELPGRTNAYRIAEVRPQVSGIILKRNFTEGGDVQAGESLYQIDPATYQASYESAKGDLAKAQAAAKIAQLTLNRYQKLLGTKYISQQDYDTALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVELITNDGIKFPQEGTLEFSDVTVDQTTGSITLRAIFPNPDKNLLPGMFVRARLEEGTNPTALLVPQQGVTRTPRGDASALVVGADNKVEMRNITATQAIGDKWLVTEGLKDGDRVIVTGLQKVRPGAQVKAQEVKSDDKQQASAAGQSEQTKS", "sequence_from_broadstreet": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQQAPEVGVVTLKSEPLQITTELPGRTNAYRIAEVRPQVSGIILKRNFTEGGDVQAGESLYQIDPATYQASYESAKGDLAKAQAAAKIAQLTLNRYQKLLGTKYISQQDYDTALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVELITNDGIKFPQEGTLEFSDVTVDQTTGSITLRAIFPNPDKNLLPGMFVRARLEEGTNPTALLVPQQGVTRTPRGDASALVVGADNKVEMRNITATQAIGDKWLVTEGLKDGDRVIVTGLQKVRPGAQVKAQEVKSDDKQQASAAGQSEQTKS", "dna_sequence_from_broadstreet": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTTTCAGGCAGCTTAGCGCTAACAGGATGTGACGACAAACCGGCTCAACAAGGAGCTCAGCAGGCGCCAGAAGTAGGCGTTGTGACGCTCAAATCTGAACCTCTACAAATCACCACCGAATTACCCGGCCGTACAAATGCTTACCGCATTGCGGAAGTGCGTCCTCAGGTTAGCGGCATTATCCTGAAACGCAACTTCACCGAAGGCGGTGATGTGCAGGCCGGTGAGTCTCTGTATCAGATTGATCCCGCAACCTATCAGGCGTCTTATGAAAGCGCGAAAGGCGATCTGGCTAAAGCGCAGGCCGCGGCTAAAATTGCCCAGCTGACGCTGAACCGCTATCAAAAACTGCTCGGTACCAAGTACATCAGTCAGCAGGATTACGATACCGCCCTGGCGGATGCCCAGCAGGCTAACGCCGCCGTGGTGGCAGCCAAAGCGGCCGTCGAAACCGCGCGCATTAACCTGGCCTATACCAAAGTGACCTCCCCTATCAGCGGTCGTATTGGTAAATCTTCCGTCACGGAAGGGGCTCTGGTGCAAAACGGTCAGACCACTGCGCTGGCGACCGTGCAGCAGCTCGATCCGATCTATGTTGACGTCACGCAGTCCAGCAATGATTTCCTGCGCCTGAAACAGGAGTTGGCTAACGGCACCCTGAAACAGGAAAACGGCAAAGCCAAAGTGGAGCTGATTACCAACGACGGTATCAAGTTCCCGCAGGAAGGGACGCTGGAATTCTCTGACGTGACGGTCGACCAGACCACCGGTTCCATCACCTTACGTGCGATTTTCCCGAACCCTGACAAAAATCTGCTGCCAGGTATGTTCGTTCGCGCACGTCTGGAAGAAGGAACGAATCCAACCGCCCTTCTGGTTCCACAGCAGGGTGTGACCCGTACGCCACGCGGCGATGCGAGCGCACTGGTTGTTGGGGCTGATAACAAAGTCGAAATGCGCAACATCACCGCCACCCAGGCGATTGGGGATAAATGGCTGGTGACGGAAGGTCTGAAAGATGGCGATCGCGTGATTGTTACTGGTTTGCAAAAAGTTCGTCCTGGCGCGCAGGTTAAAGCACAGGAAGTGAAATCTGACGATAAACAACAAGCTTCGGCCGCTGGCCAGTCAGAACAAACCAAGTCTTAA", "partial": "0", "query_start": 86156, "query_end": 87346, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 87.66}, "gnl|BL_ORD_ID|2390|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Escherichia coli acrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "670", "model_id": "2661", "ARO_accession": "3004043", "ARO_name": "Escherichia coli acrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 337, "bit_score": 656.366, "cvterm_id": "36849", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "match": "MNKNRG TPLAVVLMLSGSLALTGCDDK AQQG Q MP VG+VT+K+ PLQITTELPGRTSAYRIAEVRPQVSGIILKRNF EGSDI+AGVSLYQIDPATYQA+YDSAKGDLAKAQAAAN+ QLTV RYQKLLGT+YIS+Q+YD A+A AQQ+NAAV AAKAAVETARINLAYTKVTSPISGRIGKS VTEGALVQNGQ TALATVQQLDPIYVDVTQSSNDFLRLKQELA+G LKQENGKAKV L+T+DG+K+PQ GTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEG+NP+A+LVPQQGVTRTPRGDA+V+VVG  DKVE R + ASQAIGDKWLVT+GLK+GDRV+++GLQK++PGVQVKAQEV +D+ QQAA  A  EQ+KS", "sequence_from_db": "MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS", "sequence_from_broadstreet": "MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS", "dna_sequence_from_broadstreet": "ATGAACAAAAACAGAGGGTTTACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCCCTAACAGGATGTGACGACAAACAGGCCCAACAAGGTGGCCAGCAGATGCCCGCCGTTGGCGTAGTAACAGTCAAAACTGAACCTCTGCAGATCACAACCGAGCTTCCGGGTCGCACCAGTGCCTACCGGATCGCAGAAGTTCGTCCTCAAGTTAGCGGGATTATCCTGAAGCGTAATTTCAAAGAAGGTAGCGACATCGAAGCAGGTGTCTCTCTCTATCAGATTGATCCTGCGACCTATCAGGCGACATACGACAGTGCGAAAGGTGATCTGGCGAAAGCCCAGGCTGCAGCCAATATCGCGCAATTGACGGTGAATCGTTATCAGAAACTGCTCGGTACTCAGTACATCAGTAAGCAAGAGTACGATCAGGCTCTGGCTGATGCGCAACAGGCGAATGCTGCGGTAACTGCGGCGAAAGCTGCCGTTGAAACTGCGCGGATCAATCTGGCTTACACCAAAGTCACCTCTCCGATTAGCGGTCGCATTGGTAAGTCGAACGTGACGGAAGGCGCATTGGTACAGAACGGTCAGGCGACTGCGCTGGCAACCGTGCAGCAACTTGATCCGATCTACGTTGATGTGACCCAGTCCAGCAACGACTTCCTGCGCCTGAAACAGGAACTGGCGAATGGCACGCTGAAACAAGAGAACGGCAAAGCCAAAGTGTCACTGATCACCAGTGACGGCATTAAGTTCCCGCAGGACGGTACGCTGGAATTCTCTGACGTTACCGTTGATCAGACCACTGGGTCTATCACCCTACGCGCTATCTTCCCGAACCCGGATCACACTCTGCTGCCGGGTATGTTCGTGCGCGCACGTCTGGAAGAAGGGCTTAATCCAAACGCTATTTTAGTCCCGCAACAGGGCGTAACCCGTACGCCGCGTGGCGATGCCACCGTACTGGTAGTTGGCGCGGATGACAAAGTGGAAACCCGTCCGATCGTTGCAAGCCAGGCTATTGGCGATAAGTGGCTGGTGACAGAAGGTCTGAAAGCAGGCGATCGCGTAGTAATAAGTGGGCTGCAGAAAGTGCGTCCTGGTGTCCAGGTAAAAGCACAAGAAGTTACCGCTGATAATAACCAGCAAGCCGCAAGCGGTGCTCAGCCTGAACAGTCCAAGTCTTAA", "partial": "0", "query_start": 86156, "query_end": 87346, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 84.89}, "gnl|BL_ORD_ID|1357|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "acrE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "675", "model_id": "1445", "ARO_accession": "3000499", "ARO_name": "AcrE", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 257, "bit_score": 514.227, "cvterm_id": "36849", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKA", "match": "M K+     L   +++S +L + GC+DK  ++     P+V +  +K+APL++ TELPGRT+AYRIAEVRPQVSGI+L RNF EGSD+QAG SLYQIDPATYQA+YDSAKG+LAK++AAA +  LTVKRY  L+GTKYISQQ+YD A+A A+Q++AAV+AAKA VE+ARINLAYTKVT+PISGRIGKSTVTEGALV NGQTT LATVQQLDPIYVDVTQSSNDF+RLKQ +  G L +EN  + VELV  +G  YP  GTL+FSDVTVD++TGSITLRA+FPNP HTLLPGMFVRAR++EG+ PDA+L+PQQGV+RTPRGDA+V++V +  +VE R V ASQAIGDKWL+++GLKSGD+VIV+GLQK +PG QVKA", "sequence_from_db": "MTKHARFFLLPSFILISAAL-IAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLNRNFTEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENATSNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDATVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKA", "sequence_from_broadstreet": "MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLNRNFTEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENATSNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDATVLIVNDKSQVEARPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADTASK", "dna_sequence_from_broadstreet": "ATGACGAAACATGCCAGGTTTTTCCTCCTGCCCTCCTTTATTCTGATCTCCGCGGCTTTAATCGCCGGTTGTAACGATAAGGGAGAAGAGAAAGCTCACGTCGGTGAACCGCAGGTTACCGTTCATATTGTAAAAACGGCCCCGTTAGAAGTTAAGACTGAATTACCAGGCCGCACCAATGCTTATCGTATAGCCGAAGTTCGCCCACAGGTTAGCGGGATCGTACTGAATCGCAATTTCACTGAAGGCAGCGATGTGCAAGCAGGCCAGTCCCTGTACCAGATCGATCCCGCGACCTATCAGGCAAATTATGACAGCGCGAAAGGCGAACTGGCGAAAAGTGAAGCCGCCGCCGCCATCGCGCATTTGACGGTAAAACGTTACGTTCCGCTCGTGGGTACGAAATACATCAGCCAGCAGGAGTACGACCAGGCCATTGCTGATGCTCGTCAGGCCGATGCCGCCGTGATTGCCGCAAAAGCCACAGTCGAAAGCGCTCGCATCAATCTTGCTTATACCAAAGTCACTGCGCCAATTAGCGGACGTATCGGCAAATCGACTGTGACCGAAGGCGCTCTTGTCACTAATGGGCAAACGACTGAACTGGCGACTGTCCAGCAGCTCGATCCTATCTACGTTGATGTGACCCAATCCAGCAACGATTTTATGAGGCTGAAGCAATCCGTAGAGCAAGGAAATTTGCATAAGGAAAACGCCACCAGCAACGTAGAGTTGGTCATGGAAAACGGTCAAACCTATCCCCTGAAAGGTACGCTGCAATTCTCCGATGTGACCGTTGATGAAAGCACCGGCTCCATAACCCTACGTGCTGTCTTCCCTAACCCGCAACATACGCTTTTGCCGGGTATGTTTGTGCGTGCACGGATTGATGAAGGCGTCCAACCTGACGCCATTCTTATCCCGCAACAAGGCGTTAGCCGCACACCGCGTGGTGATGCAACCGTGCTGATTGTTAACGATAAAAGTCAGGTTGAAGCGCGCCCTGTCGTTGCCAGTCAGGCGATTGGCGATAAATGGTTGATTAGTGAAGGACTGAAATCTGGCGATCAAGTCATTGTCAGCGGCCTGCAAAAAGCGCGTCCGGGAGAGCAGGTTAAAGCCACTACCGATACCCCCGCAGATACTGCATCGAAGTAA", "partial": "0", "query_start": 86156, "query_end": 87280, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 68.53}, "gnl|BL_ORD_ID|1797|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdtE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "675", "model_id": "1903", "ARO_accession": "3000795", "ARO_name": "mdtE", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35930": {"category_aro_accession": "0000011", "category_aro_cvterm_id": "35930", "category_aro_name": "cloxacillin", "category_aro_description": "Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections.", "category_aro_class_name": "Antibiotic"}, "35973": {"category_aro_accession": "0000056", "category_aro_cvterm_id": "35973", "category_aro_name": "oxacillin", "category_aro_description": "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.20033e-143, "max_identities": 208, "bit_score": 410.609, "cvterm_id": "36839", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKA----QEVASDDKQQ", "match": "MN+ R    L + L+  G++ LT CDDK A+  A   PEVG+VTL    + + +ELPGRT  Y +AE+RPQV GII+KRNF+EG  +  G SLYQIDPA  QA  +SAKG LAKA + A+  ++T  R   LL T Y+S+QDYDTA     ++ A V  AKAAVE A INL Y  VTSPI+G  GKS+VT GALV   Q  +L TVQ+LDPIYVD+TQS  DFLR+K+E+A G++KQ  G   V+L   +G +Y Q+GTL+FSD TVD+TTGS+TLRAIFPNP+  LLPGM+V A ++EG   + LLVPQ+GVT   +G A+ +++ + D V++R++ AS+AIGD+W+VT GL++GDRVIV+GLQ+I+PG++ +A    QE AS + +Q", "sequence_from_db": "MNRRR---KLLIPLLFCGAM-LTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ", "sequence_from_broadstreet": "MNRRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ", "dna_sequence_from_broadstreet": "ATGAACAGAAGAAGAAAGCTGTTAATACCGTTGTTATTCTGCGGCGCGATGCTCACCGCCTGCGATGACAAATCGGCGGAAAACGCCGCCGCCATGACGCCTGAGGTCGGTGTCGTCACACTCTCCCCCGGTTCGGTCAATGTGTTGAGCGAATTGCCCGGTAGAACCGTTCCTTATGAAGTTGCCGAGATACGTCCCCAGGTGGGCGGTATTATCATTAAACGCAACTTTATCGAAGGCGATAAAGTGAACCAGGGCGATTCGCTGTATCAGATTGATCCTGCACCTTTACAGGCCGAGCTAAACTCCGCCAAAGGCTCGCTGGCGAAAGCGCTCTCTACCGCCAGCAATGCCCGCATCACCTTTAACCGCCAGGCATCGTTGCTGAAGACCAACTACGTTAGCCGTCAGGATTACGACACCGCGCGCACCCAGTTGAATGAAGCAGAAGCCAATGTCACCGTCGCCAAAGCGGCTGTTGAACAGGCGACGATCAATCTGCAATACGCGAATGTCACCTCGCCGATTACGGGCGTCAGCGGGAAATCGTCGGTGACCGTCGGCGCACTCGTTACCGCTAATCAGGCAGATTCGCTGGTTACCGTACAACGTCTGGACCCGATTTATGTCGATCTCACGCAGTCGGTGCAAGATTTCTTACGCATGAAAGAAGAGGTCGCCAGTGGGCAAATCAAACAGGTTCAGGGCAGTACGCCAGTACAGCTCAATCTGGAAAATGGTAAACGCTACAGCCAGACCGGCACGCTGAAATTCTCCGACCCGACAGTGGATGAAACCACGGGCTCCGTGACGTTACGGGCGATTTTCCCCAACCCAAATGGTGACTTGCTGCCTGGCATGTACGTCACGGCATTAGTGGATGAAGGTAGCCGCCAGAATGTATTACTGGTGCCGCAGGAAGGCGTCACCCACAACGCCCAGGGTAAAGCAACGGCGCTCATTCTGGATAAAGACGATGTCGTGCAGCTACGCGAAATTGAAGCCAGCAAAGCCATCGGCGACCAGTGGGTCGTCACCTCTGGCTTGCAGGCTGGCGATCGGGTGATCGTTTCCGGTTTGCAACGCATTCGTCCGGGTATCAAAGCACGAGCAATTTCCTCCAGCCAGGAAAACGCCAGCACCGAATCGAAACAATAA", "partial": "0", "query_start": 86156, "query_end": 87310, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 53.47}, "gnl|BL_ORD_ID|451|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.98469e-140, "max_identities": 217, "bit_score": 400.979, "cvterm_id": "36804", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQE-NGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK---AQEVASDDKQQAA", "match": "M +   +  L   L+++ S AL+GC    A   AQ  PEVGIVTL++  + + TELPGRT+A+RIAEVRPQV+GIILKR F EGSD++AG  LYQIDPATY+A Y SA+ +LA  Q  A       +RY+ L+  + +S+Q Y  A       NAA + +KAAVE ARINL YTKV SPISGRIG+S VTEGALV NGQ  A+ATVQQLDPIYVDVTQ S   LRL++ELA G+L++  +  AKV L   DG +YP  G LEFS+V+VD+ TGS+T+RA+FPNP++ LLPGMFV A+L+EG+   A+L PQQGVTR  +G A+ +VV   +KVE+R + A + IGDKWLVT+GL +GD++I  GLQ ++PGV+VK   A+ VAS  K  AA", "sequence_from_db": "MQRTPAMRVLVPALLVAIS-ALSGCGKSEAPPPAQ-TPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQA-------QRYKLLVADQAVSKQQYADA-------NAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAA", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 86156, "query_end": 87316, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 55.5}, "gnl|BL_ORD_ID|450|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.98469e-140, "max_identities": 217, "bit_score": 400.979, "cvterm_id": "36804", "query": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQE-NGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK---AQEVASDDKQQAA", "match": "M +   +  L   L+++ S AL+GC    A   AQ  PEVGIVTL++  + + TELPGRT+A+RIAEVRPQV+GIILKR F EGSD++AG  LYQIDPATY+A Y SA+ +LA  Q  A       +RY+ L+  + +S+Q Y  A       NAA + +KAAVE ARINL YTKV SPISGRIG+S VTEGALV NGQ  A+ATVQQLDPIYVDVTQ S   LRL++ELA G+L++  +  AKV L   DG +YP  G LEFS+V+VD+ TGS+T+RA+FPNP++ LLPGMFV A+L+EG+   A+L PQQGVTR  +G A+ +VV   +KVE+R + A + IGDKWLVT+GL +GD++I  GLQ ++PGV+VK   A+ VAS  K  AA", "sequence_from_db": "MQRTPAMRVLVPALLVAIS-ALSGCGKSEAPPPAQ-TPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQA-------QRYKLLVADQAVSKQQYADA-------NAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAA", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 86156, "query_end": 87316, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 55.5}, "gnl|BL_ORD_ID|263|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "smeD", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "284", "ARO_accession": "3003055", "ARO_name": "smeD", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.40053e-125, "max_identities": 195, "bit_score": 364.385, "cvterm_id": "37076", "query": "LTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "+ P A+ L ++ ++A  G   +  +QG     +V +VTLKS  + +T ELPGRT+A+ +AEVRPQV+GI+ KR F EG  ++AG  LYQ+D A+Y+A  ++A+  LA+A+A AN  +L+ KR  +L     +SQQD + AVA  +Q+ A V AAKA+++ A + L Y ++T+PISGRIGKS+VT+GALV  GQ  ALATVQQLDPIYVD+TQSS + L+L++ELA GRL Q+N    V ++  DG  +   GTLEFS+V+VD TTGS  LR    NPD  L+PGM+VRA +  G+  DA+LVP QG+ R P+GD + MVVG+ +KVEVR V  S+ +GDKWLV DGLK+GD+VIV GLQKI PG+ VKA E", "sequence_from_db": "IRPFALSLAIAATVAACGGQPQAPEQGPG---DVTVVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQLDDASYRAQANNARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRL-QDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATE", "sequence_from_broadstreet": "MLLSRIRPFALSLAIAATVAACGGQPQAPEQGPGDVTVVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQLDDASYRAQANNARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATEKGDAPAKPAAAAQPAAPAGDAK", "dna_sequence_from_broadstreet": "ATGTTGCTGAGCCGAATCCGACCCTTTGCACTGTCGCTGGCAATCGCCGCGACCGTGGCTGCCTGCGGCGGCCAACCCCAGGCCCCCGAGCAGGGCCCGGGTGACGTCACCGTGGTCACGCTGAAGTCCGAGACCGTGGGCCTGACCCGCGAACTGCCGGGCCGTACCAATGCCTTCCTGGTCGCCGAAGTGCGCCCGCAGGTCAATGGCATCGTGGCCAAGCGCCTGTTTACCGAGGGCGGCATGGTCAAGGCCGGCGAGCCGCTGTACCAGCTCGACGATGCCAGCTACCGGGCCCAGGCCAACAACGCCCGCGCCCAGCTGGCCCGCGCCGAAGCCACCGCCAATGCCGCGCGCCTGAGTGCCAAGCGCATCACCGAGCTGGCCAAGGTCGATGCGGTCAGCCAGCAGGACCTGGAGAACGCCGTCGCCGCGCAGAAGCAGGCCGAGGCCGACGTCGGTGCCGCCAAGGCCTCGCTGGATGCGGCCAACGTCACCCTGGGCTACGCCCGCATCACCGCGCCGATCAGCGGCCGCATCGGCAAGTCCAGCGTCACCCAGGGTGCGCTGGTCAGCGCCGGCCAGGCCAACGCACTGGCCACCGTGCAGCAGCTGGACCCGATCTATGTCGACCTGACCCAGTCCTCGGCCGAGCTGCTGCAGCTGCGCCGCGAACTGGCCGCCGGCCGCCTGCAGGACAACCAGACCCTGCCGGTCAGCATCCTGATGGAAGACGGCAGCACCTTCGAGCACAAGGGCACTCTGGAGTTCTCCGAAGTCAGCGTTGATCCGACCACCGGCAGCTTCGGCCTGCGCGTGAAGGTGGACAACCCGGACGGCCTGCTGATGCCGGGCATGTACGTGCGTGCGGTGATCGGCGGCGGCGTGCGCAGCGACGCGGTGCTGGTGCCGATGCAGGGCATCGCGCGCGATCCGAAGGGCGACACCACCGCGATGGTGGTCGGCAAGGACAACAAGGTCGAAGTGCGCCCGGTCAAGGTCAGCCGCACGGTCGGCGACAAGTGGCTGGTCGAGGACGGCCTGAAGGCCGGTGACAAGGTCATCGTCGAAGGCCTGCAGAAGATCGGCCCCGGCATGCCGGTCAAGGCCACCGAGAAGGGCGACGCACCGGCCAAGCCGGCGGCAGCCGCCCAGCCTGCCGCCCCGGCCGGCGACGCGAAGTAA", "partial": "0", "query_start": 86174, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 52.56}, "gnl|BL_ORD_ID|763|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "805", "ARO_accession": "3000800", "ARO_name": "MexC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.03515e-109, "max_identities": 171, "bit_score": 322.398, "cvterm_id": "36752", "query": "LSGSLALTGCDDKPA---QQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQ", "match": "L+ ++AL GC   PA   Q+ A+ +  V ++T+++ PL +++ELPGR    R+AEVR +V+GI++++ F EG+D++AG  L+QIDPA  +A+   A+G+LA+ +A     Q  V+RY+ L+  + +SQQD+DTA A  + + AA  +A+A +ETAR+NL Y  VT+PISGRIG++ VTEGALV  G+ T +A +QQLDPIY D TQ++ + LRL+  L  G L    G ++   +  +G  Y + G L+F+DV VD+ TG I LR  F NPD  LLPGM+VR R  +GI+  A+LVPQ+ V R+  G A VMVVG  ++ E R V      G +W +T+GL+ GDRVIV GL  ++PGV++    V   D  QA   +P+ Q", "sequence_from_db": "LAMAIALAGCG--PAEERQEAAEMVLPVEVLTVQAEPLALSSELPGRIEPVRVAEVRARVAGIVVRKRFEEGADVKAGDLLFQIDPAPLKAAVSRAEGELARNRAVLFEAQARVRRYEPLVKIQAVSQQDFDTATADLRSAEAATRSAQADLETARLNLGYASVTAPISGRIGRALVTEGALVGQGEATLMARIQQLDPIYADFTQTAAEALRLRDALKKGTLA--AGDSQALTLRVEGTPYERQGALQFADVAVDRGTGQIALRGKFANPDGVLLPGMYVRVRTPQGIDNQAILVPQRAVHRSSDGSAQVMVVGADERAESRSVGTGVMQGSRWQITEGLEPGDRVIVGGLAAVQPGVKI----VPKPDGAQAQAQSPAPQ", "sequence_from_broadstreet": "MADLRAIGRIGALAMAIALAGCGPAEERQEAAEMVLPVEVLTVQAEPLALSSELPGRIEPVRVAEVRARVAGIVVRKRFEEGADVKAGDLLFQIDPAPLKAAVSRAEGELARNRAVLFEAQARVRRYEPLVKIQAVSQQDFDTATADLRSAEAATRSAQADLETARLNLGYASVTAPISGRIGRALVTEGALVGQGEATLMARIQQLDPIYADFTQTAAEALRLRDALKKGTLAAGDSQALTLRVEGTPYERQGALQFADVAVDRGTGQIALRGKFANPDGVLLPGMYVRVRTPQGIDNQAILVPQRAVHRSSDGSAQVMVVGADERAESRSVGTGVMQGSRWQITEGLEPGDRVIVGGLAAVQPGVKIVPKPDGAQAQAQSPAPQQ", "dna_sequence_from_broadstreet": "ATGGCTGATTTGCGTGCAATAGGAAGGATCGGGGCGTTGGCTATGGCCATCGCGTTGGCGGGTTGTGGGCCGGCGGAAGAGCGACAGGAGGCCGCCGAAATGGTGTTGCCGGTGGAGGTCCTGACGGTGCAGGCCGAGCCCCTGGCGCTGAGTTCGGAACTGCCTGGGCGGATCGAACCGGTGCGGGTCGCCGAGGTGCGCGCGCGGGTGGCCGGCATCGTCGTGCGGAAGCGCTTCGAGGAGGGCGCCGACGTCAAGGCTGGCGACCTGCTGTTCCAGATCGATCCGGCACCGCTGAAGGCTGCGGTGTCGCGCGCCGAGGGTGAGCTGGCGCGGAACCGCGCGGTGCTGTTCGAGGCGCAGGCGCGGGTGCGTCGCTACGAGCCGCTGGTGAAGATCCAGGCGGTCAGCCAGCAGGACTTCGATACCGCCACCGCCGACCTGCGCAGCGCCGAGGCGGCGACCCGCTCGGCCCAGGCCGACCTGGAGACCGCGCGCCTGAACCTCGGCTACGCCTCGGTCACTGCGCCGATCTCCGGGCGCATCGGCCGCGCGCTGGTGACCGAGGGCGCGCTGGTCGGGCAGGGCGAGGCGACGCTGATGGCGCGCATCCAGCAGCTCGATCCGATCTATGCGGATTTCACCCAGACCGCGGCCGAGGCCCTGCGCCTGCGCGACGCCCTGAAGAAAGGCACCTTGGCCGCCGGCGACAGCCAGGCGCTGACCCTGCGCGTCGAAGGGACGCCCTACGAGCGCCAGGGCGCGTTGCAGTTCGCCGACGTGGCGGTGGATCGCGGCACCGGCCAGATCGCCCTGCGCGGCAAGTTCGCCAACCCCGACGGGGTCCTGCTGCCGGGCATGTACGTGCGCGTACGTACGCCCCAGGGCATCGACAACCAGGCGATCCTGGTGCCGCAACGGGCCGTGCACCGCTCCAGCGACGGCAGCGCCCAGGTGATGGTGGTGGGCGCCGACGAGCGCGCCGAGTCGCGCAGCGTCGGTACCGGCGTCATGCAGGGTTCGCGCTGGCAGATCACCGAGGGCCTGGAGCCGGGTGACCGGGTCATAGTCGGCGGCCTGGCTGCGGTGCAGCCGGGGGTGAAGATCGTGCCGAAGCCGGATGGTGCCCAGGCGCAAGCCCAGTCACCTGCGCCGCAACAGTAA", "partial": "0", "query_start": 86201, "query_end": 87337, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 44.76}, "gnl|BL_ORD_ID|1384|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "adeI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "1471", "ARO_accession": "3000780", "ARO_name": "adeI", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.28264e-105, "max_identities": 180, "bit_score": 314.694, "cvterm_id": "35531", "query": "PLAVVLMLSGSLALTGC----DDKPAQQGAQHMP--EVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVK--RYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQ--EVASDDKQQAAGNA", "match": "P      L+ S+AL GC    D+K     AQ MP  EVG++  +   ++ + EL GRTSAY+I+EVRPQ SG+ILKR F EGS ++ G +LY++D  T +A+ ++AK  L + QA  N+  L  K  RY++L+ +  +S+Q+YD  +     + A V AAKA V  A ++L Y+ + SPISG+ G+S+VT GALV   QT  L T+QQLDPIYVD+ QSS + LRL+Q+L+ G L   N   KV+L   DG  YP  G L FSD +V+Q TG+ITLRA+F NP+H LLPGM+  A++ +G+ P+A L+PQ  +TR P G A  M+V     VE R V  S   G  W+VT+GLK+GD+VIV G+ K+K G +V A+  +    + Q AA NA", "sequence_from_db": "PALTACALATSIALVGCSKGSDEKQQAAAAQKMPPAEVGVIVAQPQSVEQSVELSGRTSAYQISEVRPQTSGVILKRLFAEGSYVREGQALYELDSRTNRATLENAKASLLQQQA--NLASLRTKLNRYKQLVSSNAVSKQEYDDLLGQVNVAEAQVAAAKAQVTNANVDLGYSTIRSPISGQSGRSSVTAGALVTANQTDPLVTIQQLDPIYVDINQSSAELLRLRQQLSKGSLNNSN-NTKVKLKLEDGSTYPIEGQLAFSDASVNQDTGTITLRAVFSNPNHLLLPGMYTTAQIVQGVVPNAYLIPQAAITRLPTGQAVAMLVNAKGVVESRPVETSGVQGQNWIVTNGLKAGDKVIVDGVAKVKEGQEVSAKPYQAQPANSQGAAPNA", "sequence_from_broadstreet": "MMSAKLWAPALTACALATSIALVGCSKGSDEKQQAAAAQKMPPAEVGVIVAQPQSVEQSVELSGRTSAYQISEVRPQTSGVILKRLFAEGSYVREGQALYELDSRTNRATLENAKASLLQQQANLASLRTKLNRYKQLVSSNAVSKQEYDDLLGQVNVAEAQVAAAKAQVTNANVDLGYSTIRSPISGQSGRSSVTAGALVTANQTDPLVTIQQLDPIYVDINQSSAELLRLRQQLSKGSLNNSNNTKVKLKLEDGSTYPIEGQLAFSDASVNQDTGTITLRAVFSNPNHLLLPGMYTTAQIVQGVVPNAYLIPQAAITRLPTGQAVAMLVNAKGVVESRPVETSGVQGQNWIVTNGLKAGDKVIVDGVAKVKEGQEVSAKPYQAQPANSQGAAPNAAKPAQSGKPQAEQKAASNA", "dna_sequence_from_broadstreet": "ATGATGTCGGCTAAGCTTTGGGCACCAGCCCTTACTGCTTGCGCATTAGCAACAAGTATCGCGCTTGTTGGTTGTAGCAAAGGCTCCGATGAGAAACAGCAAGCTGCTGCTGCTCAGAAAATGCCGCCTGCAGAAGTAGGTGTTATTGTTGCTCAACCACAAAGTGTTGAACAAAGCGTTGAGCTTTCAGGCCGTACTTCAGCATATCAAATTTCTGAAGTTCGTCCTCAAACAAGTGGCGTGATTTTAAAACGTTTATTTGCTGAAGGAAGCTATGTTCGTGAAGGTCAGGCGCTTTATGAGCTCGACTCTAGAACGAACCGTGCAACGTTAGAAAATGCAAAAGCATCACTCCTACAACAACAGGCAAATCTAGCTTCACTACGTACCAAGTTAAATCGTTATAAACAACTTGTTTCTAGTAATGCTGTGTCTAAACAGGAATATGATGACTTACTTGGTCAAGTCAATGTTGCAGAAGCACAAGTTGCAGCAGCTAAGGCTCAAGTAACAAATGCAAATGTAGATCTTGGTTATTCTACAATTCGCTCTCCTATTTCTGGCCAATCTGGTCGTTCTTCAGTAACGGCTGGTGCTTTGGTTACTGCAAACCAGACTGACCCGTTGGTAACGATTCAACAATTAGATCCTATCTATGTTGATATTAATCAGTCTAGTGCTGAGTTATTGCGTTTACGTCAACAACTAAGCAAAGGCAGTTTAAATAACAGTAACAACACGAAAGTAAAATTAAAGCTTGAAGATGGTTCTACCTATCCAATCGAAGGGCAACTTGCTTTCTCTGACGCTTCTGTAAACCAAGATACAGGAACAATTACATTACGTGCCGTATTCTCTAACCCGAATCATTTATTGCTTCCGGGTATGTATACCACTGCGCAAATTGTTCAGGGCGTTGTTCCAAATGCTTACCTGATTCCTCAAGCTGCCATTACTCGTTTACCTACAGGACAAGCTGTAGCGATGCTTGTTAATGCTAAAGGGGTTGTTGAGAGCCGTCCTGTTGAAACCTCTGGTGTTCAAGGACAAAACTGGATTGTGACTAACGGCTTAAAAGCCGGCGATAAAGTCATTGTTGATGGTGTTGCCAAAGTTAAAGAAGGGCAAGAAGTATCAGCAAAACCTTATCAAGCTCAACCAGCAAACTCTCAAGGTGCAGCACCAAATGCTGCGAAACCGGCTCAATCAGGTAAACCTCAAGCAGAACAGAAAGCAGCTTCAAATGCATAA", "partial": "0", "query_start": 86180, "query_end": 87325, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 45.92}, "gnl|BL_ORD_ID|1417|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "smeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1507", "ARO_accession": "3003051", "ARO_name": "smeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.41339e-101, "max_identities": 162, "bit_score": 302.753, "cvterm_id": "37076", "query": "AQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKA", "match": "A  MPEVG++   + PL +   LPGR   + I+EVRPQ+ G+I +R F EG  ++AG  LYQ+DPA YQA++D+A+G LA+A+A     Q   +R + L+     S+QD D A +  +Q+ A V+AA+AA++ ARINL YT+VT+PI GRIG S+VT GALV  GQ TAL T+Q+LDP+Y+DVTQSS   L L++ L  G +K  +GKA+V+++  DG  Y   GTLEF    VD  TG++ LRA+ PNPD  LLPGM+++A L    +  ALLVPQ+ V R  RG+  + ++   D V  R+V+  Q +G++W +T GLK+G+RVIV+    +  G QVKA", "sequence_from_db": "APAMPEVGVIIASAQPLALQQTLPGRAVPFEISEVRPQIGGLIRQRLFTEGQQVKAGQLLYQVDPAPYQAAFDTARGQLAQAEATVLSAQPKAERTRALVSMDAASKQDADDATSALKQAQANVIAARAALQAARINLDYTRVTAPIDGRIGTSSVTAGALVAAGQDTALTTIQRLDPVYLDVTQSSTQMLALRKRLDAGLVKAIDGKAQVKVLLEDGSTYAHEGTLEFVGSAVDPGTGNVKLRAVIPNPDGLLLPGMYLKAVLPMATDARALLVPQKAVVRNERGEPLLRLLDAKDHVVERRVSTGQVVGNQWQITSGLKAGERVIVSNGSAVSLGQQVKA", "sequence_from_broadstreet": "MSLLRPLSRSPRPLLLPLLLALAACSADRTDAPAMPEVGVIIASAQPLALQQTLPGRAVPFEISEVRPQIGGLIRQRLFTEGQQVKAGQLLYQVDPAPYQAAFDTARGQLAQAEATVLSAQPKAERTRALVSMDAASKQDADDATSALKQAQANVIAARAALQAARINLDYTRVTAPIDGRIGTSSVTAGALVAAGQDTALTTIQRLDPVYLDVTQSSTQMLALRKRLDAGLVKAIDGKAQVKVLLEDGSTYAHEGTLEFVGSAVDPGTGNVKLRAVIPNPDGLLLPGMYLKAVLPMATDARALLVPQKAVVRNERGEPLLRLLDAKDHVVERRVSTGQVVGNQWQITSGLKAGERVIVSNGSAVSLGQQVKAVAPTTAQLAAMPAVDPNGNTDEKSH", "dna_sequence_from_broadstreet": "ATGTCTCTCCTGCGCCCGCTGTCCCGTTCCCCGCGTCCCCTGCTGTTGCCCCTGCTGCTGGCCCTGGCGGCCTGTTCGGCGGACAGGACCGACGCCCCGGCCATGCCCGAAGTGGGCGTCATCATCGCCAGCGCGCAGCCGCTGGCACTCCAGCAGACCTTGCCCGGCCGTGCCGTGCCGTTCGAGATCTCCGAGGTGCGGCCGCAGATCGGCGGCCTGATCCGCCAGCGGTTGTTCACCGAAGGCCAGCAGGTCAAGGCAGGGCAGCTGCTGTACCAGGTCGACCCGGCACCGTACCAGGCGGCCTTCGATACCGCCCGCGGGCAGCTGGCGCAGGCCGAGGCCACCGTGTTGTCGGCACAGCCGAAGGCCGAGCGTACCCGCGCGCTGGTGAGCATGGATGCAGCCAGCAAGCAGGACGCCGACGATGCCACCTCGGCGTTGAAGCAGGCGCAGGCCAACGTGATTGCCGCGCGCGCTGCATTGCAGGCTGCCCGCATCAACCTCGACTACACCCGGGTGACCGCCCCCATCGACGGTCGCATCGGCACCTCCAGCGTCACCGCCGGCGCGCTGGTCGCGGCCGGCCAGGATACGGCGTTGACCACCATCCAGCGGCTGGACCCGGTGTACCTGGATGTCACCCAGTCCAGCACGCAGATGCTGGCGCTGCGCAAGCGGCTCGATGCGGGCCTAGTGAAGGCCATCGATGGCAAGGCACAGGTTAAGGTGCTGCTGGAGGACGGCAGCACCTACGCGCATGAAGGCACGTTGGAGTTCGTCGGCAGCGCAGTGGATCCGGGCACCGGAAACGTGAAGCTGCGCGCGGTCATTCCGAACCCGGACGGCCTGCTGTTGCCGGGCATGTACCTGAAGGCGGTGCTGCCGATGGCCACCGACGCGCGTGCCCTGCTGGTGCCGCAGAAGGCAGTGGTGCGCAACGAACGCGGCGAACCGCTGCTGCGCCTGCTCGACGCCAAGGATCATGTGGTCGAGCGCCGCGTCAGCACCGGCCAGGTGGTCGGTAACCAGTGGCAGATCACCAGCGGCCTCAAGGCTGGCGAACGGGTGATCGTCAGCAACGGCAGCGCGGTATCGCTCGGTCAGCAGGTGAAAGCGGTGGCGCCCACGACGGCGCAGTTGGCGGCGATGCCGGCGGTCGATCCGAACGGCAACACCGACGAAAAGTCGCACTGA", "partial": "0", "query_start": 86255, "query_end": 87280, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 47.37}, "gnl|BL_ORD_ID|1260|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mtrC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "790", "model_id": "1340", "ARO_accession": "3000810", "ARO_name": "mtrC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.91955e-92, "max_identities": 151, "bit_score": 279.641, "cvterm_id": "39597", "query": "PEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQ--KIKPGVQVKAQEVASDDKQQAA", "match": "P VG+VT+    + +T ELPGR  + R A+VR QV GII KR F EGS ++AG  LYQID +TY+A  +SA+  LA AQA        + RY+ L+  + +S+Q+YD AV   + + A V AA+AA+++A I+L  +++T+PISG IG+S V+EG L+  G  T LAT++Q +P+YV+VTQS+++ ++L++++A+G+L   +G   V +  +DG  YP+ G L F+D  V+++TG ITLRA  PN  + L+PG++VR  +++    +A +VPQQ VTR  +   +VM+V     +E R+VT +Q  G  W+VT GLK GD+V+V G+    I    +V  +E AS + Q AA", "sequence_from_db": "PVVGVVTVHPQTVALTVELPGRLESLRTADVRAQVGGIIQKRLFQEGSYVRAGQPLYQIDSSTYEAGLESARAQLATAQATLAKADADLARYKPLVAAEAVSRQEYDAAVTAKRSAEAGVKAAQAAIKSAGISLNRSRITAPISGFIGQSKVSEGTLLNAGDATVLATIRQTNPMYVNVTQSASEVMKLRRQIAEGKLLAADGVIAVGIKFDDGTVYPEKGRLLFADPAVNESTGQITLRAAVPNDQNILMPGLYVRVLMDQVAVDNAFVVPQQAVTRGAKD--TVMIVNAQGGMEPREVTVAQQQGTNWIVTSGLKDGDKVVVEGISIAGITGAKKVTPKEWASSENQAAA", "sequence_from_broadstreet": "MAFYAFKAMRAAALAAAVALVLSSCGKGGDAAQGGQPAGREAPAPVVGVVTVHPQTVALTVELPGRLESLRTADVRAQVGGIIQKRLFQEGSYVRAGQPLYQIDSSTYEAGLESARAQLATAQATLAKADADLARYKPLVAAEAVSRQEYDAAVTAKRSAEAGVKAAQAAIKSAGISLNRSRITAPISGFIGQSKVSEGTLLNAGDATVLATIRQTNPMYVNVTQSASEVMKLRRQIAEGKLLAADGVIAVGIKFDDGTVYPEKGRLLFADPAVNESTGQITLRAAVPNDQNILMPGLYVRVLMDQVAVDNAFVVPQQAVTRGAKDTVMIVNAQGGMEPREVTVAQQQGTNWIVTSGLKDGDKVVVEGISIAGITGAKKVTPKEWASSENQAAAPQSGVQTASEAKPASEAK", "dna_sequence_from_broadstreet": "ATGGCTTTTTATGCTTTTAAGGCGATGCGTGCGGCCGCGTTGGCTGCCGCCGTTGCATTGGTACTGTCGTCTTGCGGTAAAGGCGGAGACGCGGCGCAGGGCGGGCAGCCTGCTGGTCGGGAAGCCCCTGCGCCCGTCGTCGGTGTCGTAACCGTCCATCCGCAAACCGTCGCATTGACCGTCGAGTTGCCGGGGCGTTTGGAATCGCTGCGTACCGCCGATGTCCGCGCCCAAGTCGGCGGCATCATCCAAAAACGCCTGTTCCAAGAAGGCAGTTATGTCCGTGCCGGACAGCCGCTGTATCAGATCGACAGTTCCACTTATGAAGCAGGTCTGGAAAGCGCGCGCGCGCAACTGGCAACGGCTCAGGCAACGCTTGCCAAAGCGGATGCGGATTTGGCGCGATACAAGCCTTTGGTTGCCGCCGAAGCCGTCAGCCGGCAGGAATACGATGCTGCGGTAACGGCGAAACGTTCTGCCGAGGCAGGCGTTAAAGCGGCGCAGGCGGCAATCAAATCCGCCGGCATCAGCCTGAACCGTTCGCGCATTACCGCGCCGATTTCCGGCTTTATCGGTCAGTCCAAAGTTTCCGAAGGTACGTTGCTGAACGCTGGCGATGCGACCGTACTGGCGACCATCCGCCAAACCAATCCGATGTATGTGAACGTTACCCAGTCTGCATCCGAAGTGATGAAATTGCGCCGTCAGATAGCCGAAGGCAAACTGCTGGCGGCGGATGGTGTGATTGCGGTCGGCATCAAATTTGACGACGGCACAGTTTACCCTGAAAAAGGCCGCCTGCTGTTTGCCGATCCGGCCGTCAACGAATCGACCGGTCAGATTACCCTGCGCGCCGCCGTACCGAACGATCAGAATATCTTGATGCCCGGTCTGTATGTGCGCGTGCTGATGGACCAAGTGGCGGTGGATAACGCATTTGTTGTGCCGCAGCAGGCGGTAACGCGCGGTGCGAAAGATACCGTGATGATTGTGAATGCCCAAGGCGGTATGGAACCCCGCGAGGTAACGGTTGCGCAACAGCAGGGTACGAATTGGATTGTTACGTCGGGTCTGAAGGACGGGGACAAGGTGGTTGTGGAAGGCATCAGTATCGCCGGTATAACGGGTGCGAAAAAGGTAACGCCCAAAGAATGGGCGTCGTCTGAAAACCAAGCCGCCGCGCCTCAATCCGGCGTTCAGACGGCATCTGAAGCCAAACCTGCTTCTGAAGCGAAATAA", "partial": "0", "query_start": 86267, "query_end": 87316, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 42.9}, "gnl|BL_ORD_ID|2484|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "AxyX", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2797", "ARO_accession": "3004143", "ARO_name": "AxyX", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.17872e-89, "max_identities": 151, "bit_score": 272.322, "cvterm_id": "41271", "query": "PLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQ-ENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "P   +   S  + ++ C  + A + A+   EVG++  ++ P  + +ELPGR   YR AEVR +V+GI+ +R + EG ++  G  L+QIDPA  QA+YDS    LA+AQA  +     ++RY  L+  + IS++D+  +VA  +Q+ A V  AKA +++AR+ L Y +VTSPI GR  ++ VTEGALV  GQ T L  VQQLDPIYV+ +Q + + ++L++++  G L+     K +V L+  DG +Y Q GTL F+D+ VD  T ++T+RA+F NP   LLPGM+VR RLE+ +N D  LVP+  + R   G A V+V G+  ++    VTA + +G  W+VT+GL  G+RV+V    ++ PG ++K  E", "sequence_from_db": "PFRTLAFASVLVLVSACSKQEAPEAAKAPAEVGVIVARATPTAVASELPGRLEPYREAEVRARVAGIVTRRLYEEGQEVTRGTPLFQIDPAPLQAAYDSEAAALARAQANLSAAADKLRRYADLVSDRAISERDHAESVAQERQARAEVALAKANLQSARLRLEYARVTSPIDGRARRALVTEGALVGEGQATPLTVVQQLDPIYVNFSQPAAEVMQLQKQIRAGALQGVAPDKMRVRLLLPDGSEYGQGGTLSFADLAVDPGTDNVTMRALFANPGRELLPGMYVRVRLEQAVNRDTFLVPRNALLRNADG-AHVLVAGDDGELRSVAVTAHRLLGPNWVVTEGLAGGERVVVENAAQLAPGQKIKPVE", "sequence_from_broadstreet": "MTHRVPFRTLAFASVLVLVSACSKQEAPEAAKAPAEVGVIVARATPTAVASELPGRLEPYREAEVRARVAGIVTRRLYEEGQEVTRGTPLFQIDPAPLQAAYDSEAAALARAQANLSAAADKLRRYADLVSDRAISERDHAESVAQERQARAEVALAKANLQSARLRLEYARVTSPIDGRARRALVTEGALVGEGQATPLTVVQQLDPIYVNFSQPAAEVMQLQKQIRAGALQGVAPDKMRVRLLLPDGSEYGQGGTLSFADLAVDPGTDNVTMRALFANPGRELLPGMYVRVRLEQAVNRDTFLVPRNALLRNADGAHVLVAGDDGELRSVAVTAHRLLGPNWVVTEGLAGGERVVVENAAQLAPGQKIKPVERTAPSAPVATAGNNEKR", "dna_sequence_from_broadstreet": "ATGACGCACCGAGTTCCCTTCAGAACGCTCGCATTCGCATCCGTACTGGTTCTCGTTTCCGCATGCTCGAAGCAGGAAGCCCCCGAAGCCGCCAAGGCCCCCGCCGAAGTCGGCGTCATCGTGGCCAGGGCCACGCCCACCGCCGTCGCCAGCGAGCTGCCCGGCCGGCTGGAGCCCTATCGCGAGGCCGAGGTCCGCGCCCGCGTGGCCGGCATCGTCACCCGCCGCCTGTATGAAGAAGGCCAGGAAGTGACGCGCGGCACGCCGCTGTTCCAGATCGATCCGGCGCCGCTGCAGGCGGCCTACGATTCCGAGGCGGCCGCGTTGGCGCGTGCCCAGGCCAACCTGTCGGCCGCCGCCGACAAGCTGCGCCGCTACGCCGACCTGGTGTCGGACCGCGCCATCAGCGAACGCGACCACGCCGAGAGCGTGGCCCAGGAACGCCAGGCCCGCGCCGAAGTGGCGTTGGCCAAGGCCAACCTGCAGAGCGCCAGGCTGCGGCTGGAATACGCCCGCGTCACCTCGCCGATCGACGGCCGCGCGCGCCGCGCGCTGGTCACCGAGGGCGCGCTGGTGGGCGAAGGCCAGGCCACGCCGCTGACGGTGGTGCAGCAACTCGACCCGATCTACGTCAACTTCTCGCAACCCGCGGCCGAGGTCATGCAGTTGCAGAAGCAGATCCGCGCCGGCGCCCTGCAAGGCGTCGCGCCCGACAAGATGCGGGTGCGCCTGCTGCTGCCGGACGGCTCCGAGTATGGCCAGGGCGGCACGCTGTCGTTCGCCGACCTGGCGGTCGACCCCGGCACCGACAACGTGACCATGCGCGCGCTGTTCGCCAACCCGGGCCGCGAACTGTTGCCGGGCATGTACGTGCGGGTGCGGCTGGAGCAGGCGGTCAACCGCGACACCTTCCTGGTGCCGCGCAACGCCCTGCTGCGCAACGCCGACGGCGCGCACGTGCTGGTGGCCGGCGACGACGGCGAGCTGCGCAGCGTGGCGGTGACCGCGCACCGGCTGCTGGGCCCGAACTGGGTCGTCACCGAGGGCCTGGCGGGCGGCGAACGCGTGGTGGTGGAAAACGCCGCGCAGCTGGCCCCCGGCCAGAAAATCAAACCGGTCGAGCGGACCGCGCCGAGCGCGCCCGTGGCGACCGCGGGAAATAACGAAAAAAGGTAA", "partial": "0", "query_start": 86180, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 40.81}, "gnl|BL_ORD_ID|1237|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "adeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1313", "ARO_accession": "3000774", "ARO_name": "adeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.11574e-83, "max_identities": 139, "bit_score": 255.758, "cvterm_id": "35507", "query": "LAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPG", "match": "L + L LS  L L GCD K   Q      +V +++++   +  +  LP R  A+R AE+RPQV GII K  F +GS+++AG +LY+I+  T++A  +S +  L KA+A     ++ ++RY++LL +  IS+Q+   A A  +Q+ A V   KA +    +NL Y  V +PISGRIG+S VTEGALV  G T  +AT+QQ+D +YVDV QS +++ RL+  L  G L   N    V +  + G  Y  +  + F D+ VD  TG +T R    N +  LLPGM+VR  ++    P ALLVP Q + R   G+  V V+      E+R +   Q     ++   GLK GDRV+V G+++IKP ", "sequence_from_db": "LLLPLFLSIGLILQGCDSKEVAQAEPPPAKVSVLSIQPQSVNFSENLPARVHAFRTAEIRPQVGGIIEKVLFKQGSEVRAGQALYKINSETFEADVNSNRASLNKAEAEVARLKVQLERYEQLLPSNAISKQEVSNAQAQYRQALADVAQMKALLARQNLNLQYATVRAPISGRIGQSFVTEGALVGQGDTNTMATIQQIDKVYVDVKQSVSEYERLQAALQSGELS-ANSDKTVRITNSHGQPYNVTAKMLFEDINVDPETGDVTFRIEVNNTERKLLPGMYVRVNIDRASIPQALLVPAQAIQRNISGEPQVYVINAQGTAEIRPIEIGQQYEQFYIANKGLKVGDRVVVEGIERIKPN", "sequence_from_broadstreet": "MQKHLLLPLFLSIGLILQGCDSKEVAQAEPPPAKVSVLSIQPQSVNFSENLPARVHAFRTAEIRPQVGGIIEKVLFKQGSEVRAGQALYKINSETFEADVNSNRASLNKAEAEVARLKVQLERYEQLLPSNAISKQEVSNAQAQYRQALADVAQMKALLARQNLNLQYATVRAPISGRIGQSFVTEGALVGQGDTNTMATIQQIDKVYVDVKQSVSEYERLQAALQSGELSANSDKTVRITNSHGQPYNVTAKMLFEDINVDPETGDVTFRIEVNNTERKLLPGMYVRVNIDRASIPQALLVPAQAIQRNISGEPQVYVINAQGTAEIRPIEIGQQYEQFYIANKGLKVGDRVVVEGIERIKPNQKLALAAWKAPAVANHASSVETKTSIAEGAQP", "dna_sequence_from_broadstreet": "ATGCAAAAGCATCTTTTACTTCCTTTATTTTTATCTATTGGGCTGATATTACAGGGGTGTGATTCAAAAGAAGTCGCTCAAGCTGAGCCACCACCGGCTAAAGTCAGTGTATTAAGCATTCAACCGCAATCGGTAAATTTTAGTGAAAATCTTCCTGCACGTGTACATGCATTCCGTACGGCGGAAATCCGTCCGCAAGTCGGAGGTATCATTGAAAAGGTTCTATTTAAACAAGGTAGTGAAGTTAGAGCAGGGCAAGCCTTATATAAAATTAATTCCGAGACTTTTGAGGCCGATGTAAATAGCAATAGAGCTTCTCTCAATAAAGCTGAAGCTGAGGTGGCAAGACTCAAAGTTCAGTTAGAACGTTATGAGCAGTTATTACCAAGTAATGCAATTAGTAAGCAAGAAGTAAGTAATGCTCAAGCTCAGTATCGTCAGGCTCTAGCCGATGTCGCTCAAATGAAAGCATTGCTGGCCAGACAAAACTTGAATCTGCAATATGCAACAGTTCGAGCGCCTATTTCTGGGCGTATTGGGCAATCTTTTGTCACTGAAGGTGCATTGGTCGGTCAGGGCGATACCAATACGATGGCAACCATTCAACAGATTGATAAAGTCTATGTTGATGTAAAGCAATCGGTTAGTGAGTATGAACGCCTACAGGCTGCGCTACAAAGCGGCGAATTATCAGCAAATAGTGACAAAACCGTTCGTATTACCAATAGCCACGGACAGCCCTATAACGTCACAGCAAAAATGTTGTTTGAAGATATTAATGTTGACCCGGAAACAGGCGATGTCACATTCCGTATTGAAGTTAATAACACTGAACGAAAATTACTTCCGGGCATGTATGTGCGTGTCAATATTGATCGTGCTTCTATTCCTCAAGCGCTATTGGTTCCGGCGCAAGCGATCCAACGTAATATCAGTGGCGAGCCTCAGGTATATGTCATTAACGCCCAAGGGACAGCGGAAATTCGTCCTATCGAAATTGGACAGCAATATGAGCAGTTCTATATCGCTAACAAAGGCTTGAAAGTCGGTGACAGAGTCGTTGTTGAAGGTATTGAACGTATTAAGCCAAATCAAAAATTGGCATTGGCAGCATGGAAAGCACCAGCCGTCGCGAATCATGCTTCAAGTGTAGAAACCAAAACTTCTATAGCTGAAGGGGCACAACCATGA", "partial": "0", "query_start": 86183, "query_end": 87265, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 38.5}, "gnl|BL_ORD_ID|1450|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "amrA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "1542", "ARO_accession": "3002982", "ARO_name": "amrA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.56101e-77, "max_identities": 146, "bit_score": 241.506, "cvterm_id": "41211", "query": "GCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAA--ANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGR---LKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "GC    ++  A    E  +VT+K   + ++ ELPGR  AYR AEVR +V+GI+  R + EG +++ G  L++IDPA ++A+ D+A G L KA+AA  A +D+   +RY +L+  + +S++D+  A+A  +Q+ AAV +A+A +  A++ L Y  VT+PI GR  ++ VTEGALV   Q T L TV+QLDPIYV+ +Q + D   L++ +  GR   + Q++   +V LV  DG  Y + G L F+D+ VD +T ++ +RA+FPNP+  LLPG +VR  L+  +  DA+LVP+  + RT    A+V VVG+  K+    V A+Q  G  W+VT GL  G+RV+V    + + G  VKA E", "sequence_from_db": "GCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKARAAHLAALDKR--RRYDELVRDRAVSERDHTEALADERQAKAAVASARAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQQD--VEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTA-DSATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALE", "sequence_from_broadstreet": "MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKARAAHLAALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASARAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQQDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTADSATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST", "dna_sequence_from_broadstreet": "ATGAAATACGAATGGGCACGCACGCGCCGCTTGTCGGCGGCGCTCGCGGTCGCGGCGTTCGTCGCGGCCGGCTGCGGCAAGCACGAAAGCGAGCACGACGCCGCCGCGCCGCGCGAGGCGAGCGTCGTCACGGTGAAGAAGACATCGGTGCCGCTGTCGGTCGAATTGCCGGGCCGGCTCGACGCGTACCGGCAGGCCGAGGTGCGCGCGCGGGTCGCGGGCATCGTGACCGCGCGCACCTACGAGGAAGGGCAGGAAGTCAAGCGCGGCGCGGTGCTGTTCAGGATCGATCCCGCGCCGTTCAAGGCGGCGCGCGACGCGGCCGCGGGCGCGCTCGAGAAGGCGCGGGCCGCGCACCTCGCGGCGCTCGACAAGCGCCGCCGCTATGACGAGCTCGTGCGCGACCGCGCGGTCAGCGAGCGCGACCACACCGAGGCGCTCGCCGACGAACGGCAGGCGAAGGCGGCCGTCGCGTCGGCGCGCGCGGAGCTCGCGCGCGCGCAACTGCAGCTCGATTACGCGACCGTCACCGCGCCGATCGACGGCCGCGCGCGCCGCGCGCTCGTGACCGAAGGCGCGCTCGTCGGCCAGGATCAGGCGACGCCGCTCACGACCGTCGAGCAGCTCGATCCGATCTACGTGAACTTCTCGCAGCCCGCGGCCGACGTCGAATCGCTGCGGCGCGCGGTGAAGAGCGGACGCGCGGCGGGCATCGCGCAGCAGGACGTCGAGGTGACGCTCGTGCGCCCGGACGGCAGCACGTACGCGCGCAAGGGCAAGCTGCTGTTCGCGGATCTTGCCGTCGACCCGTCCACCGACACGGTGGCGATGCGTGCGCTCTTTCCGAACCCGGAGCGCGAACTGCTGCCCGGCGCGTACGTGCGGATCGCGCTCGATCGCGCGGTCGCGCGCGACGCGATCCTCGTGCCGCGCGACGCGCTGCTGCGCACGGCCGACAGCGCGACCGTCAAGGTCGTCGGCCAGAACGGCAAGATACGCGACGTGACGGTCGAGGCCGCGCAGATGAAAGGCCGCGACTGGATCGTCACGCGCGGGCTCGCGGGCGGCGAGCGCGTCGTCGTCGTCGACGCCGCGCAATTCGAAGCAGGCACGACGGTGAAGGCGCTCGAGCGCGGCGCCGCCGCGCAGCCGGCCTCCGGCGCCGCCGCGGCTTCCGCGCCCGGCCGGCGCTCAACCTGA", "partial": "0", "query_start": 86225, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 40.67}, "gnl|BL_ORD_ID|313|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexX", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "730", "model_id": "334", "ARO_accession": "3003034", "ARO_name": "mexX", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.22745e-69, "max_identities": 144, "bit_score": 220.32, "cvterm_id": "36804", "query": "GCDDKP-AQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDL-AKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAK-VELVTNDGL--KYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPS", "match": "GC++   A + A+   EVG++  + AP+ IT+ELPGR  AYR AEVR +V+GI+ +R + EG D++AG  L+QIDPA  +A+ D ++G L  + Q  A  D+L  K Y  L+  + IS+++Y  A   A+Q+ A + +AKA +E AR+ L Y  VT+PI GR  ++ VTEGALV     T L  V+Q+DPIYV+ +Q +    + +    D R   E  + +        G   + P +G L F D+ VD  T +I +RA+F NP   LLPG +V+ RL+  +NP A+ VP   + RT +  A V VV     VE  +V A    G  W+++ GLK G+ VIV    +   G  V+A       +Q A+ +APS", "sequence_from_db": "GCEEAADAGKTAEAPAEVGVIVARPAPIGITSELPGRLEAYRQAEVRARVAGIVTRRLYEEGQDVRAGTVLFQIDPAPLKAALDISRGALPGRGQPRAAADKL--KAYADLIKDRAISEREYTEAQTDARQALAQIASAKAELEQARLRLGYATVTAPIDGRARRALVTEGALVGEDSPTPLTRVEQIDPIYVNFSQPAA---KSRHAAGDPRRPGEGCRRQGHRRAPGPGRRQRVPLAGELLFIDLAVDPGTDTIAMRALFRNPHRELLPGGYVQVRLQRAVNPQAITVP-DALIRTAQ-SAVVKVVNPKGLVEDVEVRADTLQGRDWIISRGLKGGEWVIVENAAQHAAGSSVQAVV-----RQPASADAPS", "sequence_from_broadstreet": "MDRLAARLLAALVALFLLGCEEAADAGKTAEAPAEVGVIVARPAPIGITSELPGRLEAYRQAEVRARVAGIVTRRLYEEGQDVRAGTVLFQIDPAPLKAALDISRGALPGRGQPRAAADKLKAYADLIKDRAISEREYTEAQTDARQALAQIASAKAELEQARLRLGYATVTAPIDGRARRALVTEGALVGEDSPTPLTRVEQIDPIYVNFSQPAAKSRHAAGDPRRPGEGCRRQGHRRAPGPGRRQRVPLAGELLFIDLAVDPGTDTIAMRALFRNPHRELLPGGYVQVRLQRAVNPQAITVPDALIRTAQSAVVKVVNPKGLVEDVEVRADTLQGRDWIISRGLKGGEWVIVENAAQHAAGSSVQAVVRQPASADAPSPLAASPAGQ", "dna_sequence_from_broadstreet": "ATGGACCGGCTCGCTGCGCGGCTGCTGGCGGCCCTGGTCGCCCTATTCCTGCTGGGCTGCGAAGAAGCAGCGGACGCCGGGAAGACTGCGGAGGCCCCCGCCGAGGTCGGCGTGATCGTCGCCAGGCCGGCGCCTATCGGCATCACCAGCGAGCTGCCCGGACGCCTGGAAGCGTACCGCCAGGCTGAAGTGCGGGCGCGCGTCGCCGGCATCGTCACCCGTCGCCTGTACGAGGAAGGCCAGGACGTCCGCGCCGGCACCGTGCTGTTCCAGATCGACCCTGCGCCCTTGAAGGCGGCCCTGGACATCAGCCGCGGCGCCCTGCCCGGCCGAGGCCAGCCACGCGCGGCGGCCGACAAGCTCAAGGCGTACGCCGACCTGATCAAGGACCGCGCCATCAGCGAACGCGAGTACACCGAAGCGCAGACCGACGCGCGCCAGGCCCTGGCGCAGATCGCCTCGGCCAAGGCCGAACTGGAGCAGGCCCGCCTGCGCCTGGGCTACGCCACGGTCACCGCGCCGATCGACGGCCGCGCGCGGCGTGCGCTGGTCACCGAAGGCGCGCTGGTCGGCGAGGACTCGCCGACACCGCTGACCCGCGTCGAGCAGATCGATCCGATCTACGTGAACTTCTCCCAGCCGGCCGCGAAGTCGCGCCATGCAGCGGGCGATCCGCGAAGGCCAGGTGAAGGGTGTCGCCGACAAGGACATCGCCGTGCGCCTGGTCCTGGCCGACGGCAGCGAGTACCGCTGGCCGGCGAGCTGCTGTTCATCGACCTGGCGGTCGACCCCGGCACCGACACCATCGCCATGCGTGCCCTGTTCCGCAATCCGCATCGCGAATTGCTGCCCGGCGGCTACGTGCAGGTGCGCCTGCAGCGCGCGGTGAACCCGCAGGCGATCACCGTCCCGGACGCGCTGATCCGTACCGCCCAGTCCGCCGTGGTCAAGGTGGTCAACCCAAAGGGCTTGGTGGAAGACGTGGAGGTCCGCGCCGACACCCTGCAGGGCCGCGACTGGATCATCAGCCGCGGGCTCAAGGGCGGCGAGTGGGTGATCGTCGAGAACGCCGCCCAGCATGCCGCCGGCTCCAGCGTCCAGGCGGTGGTCCGCCAGCCGGCCAGCGCCGACGCCCCCTCACCGCTGGCCGCCTCGCCGGCGGGCCAGTGA", "partial": "0", "query_start": 86225, "query_end": 87331, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 38.5}, "gnl|BL_ORD_ID|1153|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "adeG", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "1226", "ARO_accession": "3000778", "ARO_name": "adeG", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.13297e-48, "max_identities": 112, "bit_score": 166.392, "cvterm_id": "35535", "query": "ELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQ----TTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEG-INPDALLVPQQ-GVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSE", "match": "E  GR  A    ++RPQVSG ++  +F +GS ++ G  L+ IDP  ++A  + AK  LA A+A        + R Q+L+ +  +S+Q+ D A   A+ +NA + AA+AAV++AR+NL YT++T+P+SGRI ++ VT G +V  G      T+L +V +L   Y         +L+          ++ + +  V +   +   + + GT+   D  ++ T+G+I +RA F NP+  LLPG++ R RL  G   P  L+ P   GV +  R    V+VV   ++   R+V          +V  GL++GDR++V GLQ+I+PG  V    V   + Q  A   P +", "sequence_from_db": "EYSGRLEAIDQVDIRPQVSGKLIAVHFKDGSLVKKGDLLFTIDPRPFEAELNRAKAQLASAEAQVTYTASNLSRIQRLIQSNAVSRQELDLAENDARSANANLQAARAAVQSARLNLEYTRITAPVSGRISRAEVTVGNVVSAGNGAQVLTSLVSVSRL---YASFDVDEQTYLKYISN------QRNSAQVPVYMGLANETGFTREGTINSIDNNLNTTSGTIRVRATFDNPNGVLLPGLYARIRLGGGQPRPAILISPTAVGVDQDKR---FVVVVDAKNQTAYREVKLGAQQDGLQIVNSGLQAGDRIVVNGLQRIRPGDPVTPHLVPMPNSQITASATPPQ", "sequence_from_broadstreet": "MSFSRKQFALSAIFVAILATGGSFMLLHENADAKAAPTAAQQAATVDVAPVVSKTITDWQEYSGRLEAIDQVDIRPQVSGKLIAVHFKDGSLVKKGDLLFTIDPRPFEAELNRAKAQLASAEAQVTYTASNLSRIQRLIQSNAVSRQELDLAENDARSANANLQAARAAVQSARLNLEYTRITAPVSGRISRAEVTVGNVVSAGNGAQVLTSLVSVSRLYASFDVDEQTYLKYISNQRNSAQVPVYMGLANETGFTREGTINSIDNNLNTTSGTIRVRATFDNPNGVLLPGLYARIRLGGGQPRPAILISPTAVGVDQDKRFVVVVDAKNQTAYREVKLGAQQDGLQIVNSGLQAGDRIVVNGLQRIRPGDPVTPHLVPMPNSQITASATPPQPQPTDKTSTPAKG", "dna_sequence_from_broadstreet": "ATGTCATTTTCCCGCAAACAGTTTGCACTGTCTGCCATCTTTGTCGCTATTTTAGCAACCGGTGGCAGTTTTATGTTGTTACATGAAAATGCCGATGCAAAAGCTGCACCAACCGCTGCCCAACAAGCTGCTACTGTTGATGTAGCCCCAGTAGTAAGCAAAACCATTACCGATTGGCAAGAATATTCCGGTCGTTTAGAAGCAATTGATCAAGTTGATATTCGGCCTCAAGTTTCAGGAAAACTTATTGCCGTACATTTCAAAGATGGAAGCCTCGTTAAAAAAGGTGATTTACTTTTCACAATCGACCCTCGTCCTTTTGAAGCAGAACTGAACCGTGCAAAAGCCCAACTTGCTTCAGCTGAAGCACAGGTAACATATACCGCAAGCAATCTTTCGCGTATTCAACGTCTCATTCAGAGTAATGCTGTTTCTCGCCAAGAACTGGATTTAGCCGAAAATGATGCACGTTCAGCGAATGCTAACCTACAAGCCGCTAGAGCTGCTGTCCAATCTGCACGTTTAAATCTAGAATACACCCGTATTACAGCACCTGTCAGCGGCCGGATTTCACGAGCTGAAGTCACCGTTGGTAATGTAGTTTCTGCAGGTAACGGCGCACAGGTTTTAACAAGTTTAGTGTCTGTATCCCGCCTTTATGCATCTTTCGATGTTGATGAACAAACTTACCTGAAATATATCAGTAATCAGCGTAATTCAGCACAAGTACCTGTCTATATGGGACTTGCCAATGAAACAGGCTTTACTCGTGAAGGTACAATCAACTCAATCGATAACAATCTGAATACAACCTCAGGTACGATCCGTGTTCGCGCAACTTTTGACAATCCAAACGGTGTTTTATTACCAGGCCTATATGCACGAATTCGTTTAGGTGGAGGCCAACCTCGCCCAGCGATTCTGATTAGTCCAACCGCGGTTGGTGTCGACCAAGATAAACGTTTTGTCGTAGTAGTAGATGCGAAAAATCAAACTGCTTATCGCGAAGTAAAACTCGGTGCCCAACAAGATGGCTTGCAAATCGTAAATAGCGGATTACAAGCGGGTGATCGTATTGTAGTGAATGGTTTACAACGGATTCGTCCGGGTGACCCTGTTACACCGCATCTCGTCCCTATGCCAAATTCACAAATCACTGCTAGCGCTACTCCTCCTCAACCTCAGCCAACAGATAAAACATCAACTCCGGCAAAAGGTTAA", "partial": "0", "query_start": 86318, "query_end": 87334, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.46}, "gnl|BL_ORD_ID|1112|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "cmeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "710", "model_id": "1181", "ARO_accession": "3000783", "ARO_name": "cmeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "36989": {"category_aro_accession": "3000645", "category_aro_cvterm_id": "36989", "category_aro_name": "cefotaxime", "category_aro_description": "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "37139": {"category_aro_accession": "3000759", "category_aro_cvterm_id": "37139", "category_aro_name": "fusidic acid", "category_aro_description": "Fusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to  block protein synthesis.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.13079e-47, "max_identities": 115, "bit_score": 162.54, "cvterm_id": "37595", "query": "VLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTL--KSAPLQITTELPGR-TSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK", "match": "+L+L     LT C  + A +    MP   + T+  KS  L +    P +  S Y +  ++PQVSG+I+ + F  G  ++ G +L+ I+ A ++AS DSA G    A+A          R + L     ISQ++YD+++AT   + A++ +A+A +  ARI+L +T++ +P  G IG + V  G  V    TT L  V  L+PIY D   S  D L L +    G+   ++  A + L   +G      G L F D  +D  +G++  +A+F N + TLLPG F     E  I  +   VPQ  + +  + D  V++V  G KVE   V  S    +  ++  GL++GD++I+   +KI+ G +VK", "sequence_from_db": "ILVLGVVFLLTACSKEEAPK--IQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVI-IKPQVSGVIVNKLFKAGDKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQLANARIDLDHTEIKAPFDGTIGDALVNIGDYVSTS-TTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLNL---NG--ETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQIAI-KQDQNDVYVLLVKNG-KVEKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSEVK", "sequence_from_broadstreet": "MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVIIKPQVSGVIVNKLFKAGDKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQLANARIDLDHTEIKAPFDGTIGDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLNLNGETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQIAIKQDQNDVYVLLVKNGKVEKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSEVKEIGAQ", "dna_sequence_from_broadstreet": "ATGAAATTATTTCAAAAAAATACTATTTTAGTTTTAGGTGTTGTGTTTTTACTCACTGCTTGCAGCAAAGAAGAAGCGCCAAAAATACAAATGCCGCCTCAACCTGTAACAACCATGAGTGCTAAATCTGAAGATTTACCACTTAATTTTACCTATCCTGCCAAACTTGTCAGTGATTATGATGTTATTATAAAACCTCAAGTTAGCGGTGTGATAGTAAATAAACTTTTTAAGGCTGGAGATAAGGTAAAAAGAGGACAAACATTATTTATTATAGAACAAGCCAAATTTAAAGCTAGCGTTGATTCAGCCTACGGACAAGCGTTAATGGCTAAAGCAACTTTCGAAAATGCAAGTAAAGATTTTAATCGCTCTGAGGCTCTTTTTAGCAAAAACGCAATCTCTCAAAAAGAATACGACTCTTCTCTTGCTACATTTAATAATGCAAAAGCTAGTCTAGCAAGTGCTAGAGCACAGCTTGCAAATGCAAGAATTGATCTAGATCATACCGAAATAAAAGCTCCTTTTGATGGTACTATAGGAGATGCTTTAGTTAATATAGGAGATTATGTAAGCACTTCAACAACTGAACTAGTTAGAGTTACAAATTTAAATCCTATTTACGCAGATTTCTTTATTTCAGATACAGATAAACTAAATTTAGTCCGCAATACTCAAAGTGGAAAATGGGATTTAGACAGCATTCATGCAAATTTAAATCTTAACGGAGAAACTGTTCAAGGCAAACTTTATTTTATTGATTCTGTTATAGATGCCAATAGTGGAACAGTAAAAGCCAAAGCTGTATTTGATAACAACAACTCGACACTTTTACCAGGTGCTTTTGCAACGATTACCTCAGAAGGTTTTATACAAAAAAATGGCTTTAAGGTACCTCAAATAGCTATTAAACAAGATCAAAATGATGTTTATGTTCTTCTTGTTAAAAATGGAAAAGTAGAAAAATCTTCTGTACATATAAGCTACCAAAACAATGAATACGCTATTATTGACAAAGGATTGCAAAATGGCGATAAAATCATTTTGGATAATTTTAAAAAAATTCAAGTTGGTAGCGAAGTTAAAGAAATTGGAGCACAATAA", "partial": "0", "query_start": 86192, "query_end": 87277, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 31.51}, "gnl|BL_ORD_ID|2355|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MuxA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "2717", "ARO_accession": "3004073", "ARO_name": "MuxA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "37626": {"category_aro_accession": "3001227", "category_aro_cvterm_id": "37626", "category_aro_name": "kitasamycin", "category_aro_description": "Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens.", "category_aro_class_name": "Antibiotic"}, "40353": {"category_aro_accession": "3003701", "category_aro_cvterm_id": "40353", "category_aro_name": "rokitamycin", "category_aro_description": "Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.81611e-47, "max_identities": 111, "bit_score": 162.54, "cvterm_id": "36804", "query": "VGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGL--KYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVA", "match": "VG+  ++   L +     G  +A+    V+P+V+G ++K  F EG +++AG  L  +DP TY+A+   A+G L + QA     ++ ++RY+ L     I++Q  DT  A  +Q    +   +  V+ AR+NL +T+V +PISGR+G   V  G LV +G TT L  + Q+ PI V           L Q+     ++Q NG  K+ +   D    K    GTL   D  +D TTG++ L+A F N D  L P  FV  RL        L +P   V R   G   V VVG  +KV  R V    +  ++ +V  GLK+G++V+V G  +++ G++V+  E +", "sequence_from_db": "VGVARVEQGDLALHFNALGTVTAFNTVNVKPRVNGELVKVLFQEGQEVKAGDLLAVVDPRTYKAALAQAEGTLMQNQAQLKNAEIDLQRYKGLYAEDSIAKQTLDTQEAQVRQLQGTIRTNQGQVDDARLNLTFTEVRAPISGRLGLRQVDIGNLVTSGDTTPLVVITQVKPISV--------VFSLPQQQIGTVVEQMNGPGKLTVTALDRNQDKVLAEGTLTTLDNQIDTTTGTVKLKARFENADGKLFPNQFVNVRLLAQTLKGVLTIPANAVQRGTNG-IYVYVVGADNKVSQRSVAIGTSENERVVVESGLKAGEQVVVEGTDRLRDGMEVRVAEAS", "sequence_from_broadstreet": "MTPTTGKSKFRTLRPWLITALAFAAVIGLVMWLAAPASAPSSDGRPGRGGKPGAALPKANALTVGVARVEQGDLALHFNALGTVTAFNTVNVKPRVNGELVKVLFQEGQEVKAGDLLAVVDPRTYKAALAQAEGTLMQNQAQLKNAEIDLQRYKGLYAEDSIAKQTLDTQEAQVRQLQGTIRTNQGQVDDARLNLTFTEVRAPISGRLGLRQVDIGNLVTSGDTTPLVVITQVKPISVVFSLPQQQIGTVVEQMNGPGKLTVTALDRNQDKVLAEGTLTTLDNQIDTTTGTVKLKARFENADGKLFPNQFVNVRLLAQTLKGVLTIPANAVQRGTNGIYVYVVGADNKVSQRSVAIGTSENERVVVESGLKAGEQVVVEGTDRLRDGMEVRVAEASPQVLEGEPQKPQTGRPSGLQGDSVGSGSAE", "dna_sequence_from_broadstreet": "ATGACTCCAACGACCGGTAAATCCAAGTTCCGTACCCTGCGCCCGTGGCTGATCACCGCCCTGGCCTTCGCCGCCGTGATCGGCCTGGTGATGTGGCTGGCGGCGCCCGCCTCGGCACCGTCCTCCGACGGGCGACCCGGTCGCGGCGGCAAGCCGGGCGCCGCGCTGCCCAAGGCCAACGCGCTCACCGTCGGCGTGGCCAGGGTGGAGCAGGGCGACCTGGCGCTGCATTTCAACGCGCTTGGCACCGTCACCGCCTTCAACACGGTGAACGTCAAGCCGCGGGTCAACGGCGAGCTGGTCAAGGTGCTGTTCCAGGAGGGGCAGGAGGTCAAGGCCGGCGACCTGCTGGCGGTGGTCGACCCGCGCACCTACAAGGCGGCGCTGGCCCAGGCCGAGGGCACGCTGATGCAGAACCAGGCGCAACTGAAGAACGCCGAGATCGACCTGCAGCGCTACAAGGGGCTGTATGCCGAGGACTCGATAGCCAAGCAGACCCTGGATACCCAGGAAGCCCAGGTCCGCCAGTTGCAGGGCACCATCCGTACCAACCAGGGCCAGGTCGACGACGCCCGCCTCAACCTGACCTTCACCGAGGTCCGCGCACCGATTTCCGGGCGCCTCGGCCTGCGCCAGGTGGACATCGGCAACCTGGTCACCAGCGGCGATACCACGCCGCTGGTGGTGATCACCCAGGTCAAGCCGATCTCGGTGGTGTTCAGCCTGCCGCAGCAGCAGATCGGCACCGTCGTCGAGCAGATGAACGGCCCCGGCAAGCTGACGGTCACCGCGCTGGACCGCAACCAGGACAAGGTTCTCGCCGAAGGCACCCTGACCACCCTGGACAACCAGATCGACACCACCACCGGCACGGTCAAGCTCAAGGCGCGCTTCGAGAACGCCGACGGCAAGCTGTTCCCCAACCAGTTCGTCAACGTGCGCCTGCTGGCGCAGACCCTCAAAGGCGTGCTGACCATTCCGGCCAACGCCGTGCAGCGCGGCACCAACGGTATCTATGTCTACGTGGTCGGCGCCGACAACAAGGTCAGCCAGCGCAGCGTCGCCATCGGCACCAGCGAGAACGAGCGGGTGGTGGTGGAAAGCGGCCTGAAGGCCGGCGAGCAGGTGGTGGTGGAAGGCACCGACCGCCTGCGCGACGGTATGGAAGTGCGTGTCGCCGAGGCCTCCCCGCAGGTCCTCGAGGGCGAGCCGCAGAAACCGCAGACTGGCCGCCCCAGCGGCCTCCAGGGCGACTCGGTGGGTAGCGGGAGCGCTGAATGA", "partial": "0", "query_start": 86273, "query_end": 87292, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.46}, "gnl|BL_ORD_ID|2216|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "oqxA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "670", "model_id": "2399", "ARO_accession": "3003922", "ARO_name": "oqxA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35992": {"category_aro_accession": "0000075", "category_aro_cvterm_id": "35992", "category_aro_name": "nitrofurantoin", "category_aro_description": "Nitrofurantoin is an antibiotic used to treat urinary tract infections. It inhibits enzyme synthesis by inhibiting essential enzymes involved in the citric acid cycle, as well as those involved in DNA, RNA, and protein synthesis. It is marketed under the following brand names: Furadantin, Macrobid, Macrodantin, Nitro Macro and Urantoin.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "41240": {"category_aro_accession": "3004116", "category_aro_cvterm_id": "41240", "category_aro_name": "nitrofuran antibiotic", "category_aro_description": "Nitrofurans are chemotherapeutic agents with antibacterial and antiprotozoal activity.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.9914e-46, "max_identities": 126, "bit_score": 160.614, "cvterm_id": "35914", "query": "NRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATV---QQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKA---KVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKI-KPGVQVKAQEVA", "match": "N  LT L  +++   S  L GCDD  AQ  A   P V    +    +       GR  A    ++RP+VSG I K N+ +G +++ G  L+ ID  TY+A+ + A+  LA+A+  A++ Q    R  KL+ T  +S+++++   + A Q+ A + AA+AAV+ A++NL +TKVT+PI GR  ++ +T G LV  G T ++ T    Q+   +Y DV +S+  +L  +     G+    + +A   ++ LV  +G  YP  G ++F D  +  +TG+I +RA+  N      PG+F R RL       A L+  + V  T +    V +V +  K + R +T  +      +V  GL  GD VIV GLQK+  PG+ V A+ VA", "sequence_from_db": "NIHLTALGAMML---SFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDEST--YLHYQNLARRGQGASSDNQALPVEIGLVGEEG--YPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVL-TDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVA", "sequence_from_broadstreet": "MSLQKTWGNIHLTALGAMMLSFLLVGCDDSVAQNAAPPAPTVSAAKVLVKSISQWDSFNGRIEAVESVQLRPRVSGYIDKVNYTDGQEVKKGQVLFTIDDRTYRAALEQAQAALARAKTQASLAQSEANRTDKLVHTNLVSREEWEQRRSAAVQAQADIRAAQAAVDAAQLNLDFTKVTAPIDGRASRALITSGNLVTAGDTASVLTTLVSQKTVYVYFDVDESTYLHYQNLARRGQGASSDNQALPVEIGLVGEEGYPHQGKVDFLDNQLTPSTGTIRMRALLDNSQRLFTPGLFARVRLPGSAEFKATLIDDKAVLTDQDRKYVYIVDKDGKAQRRDITPGRLADGLRIVQKGLNPGDSVIVDGLQKVFMPGMPVNAKTVAMTSSATLN", "dna_sequence_from_broadstreet": "ATGAGCCTGCAAAAAACCTGGGGAAACATTCACCTGACCGCGCTCGGCGCGATGATGCTCTCCTTTCTGCTCGTCGGCTGCGACGACAGCGTCGCACAGAATGCTGCGCCTCCCGCCCCGACGGTCAGCGCCGCTAAGGTGCTGGTGAAGTCGATCAGTCAGTGGGATAGTTTTAACGGTCGCATTGAAGCGGTGGAGAGCGTTCAGCTTCGCCCTCGCGTCTCGGGATACATTGATAAAGTGAATTACACTGACGGCCAGGAGGTGAAAAAGGGCCAGGTGCTGTTCACGATAGATGACAGAACCTATCGCGCCGCGCTGGAGCAGGCGCAGGCGGCGTTGGCAAGAGCCAAAACGCAGGCCAGCCTCGCGCAAAGCGAGGCGAACCGCACCGATAAATTAGTCCATACCAACCTCGTCTCCCGTGAAGAGTGGGAGCAGCGCCGGTCAGCCGCGGTTCAGGCGCAGGCCGACATTCGCGCCGCGCAGGCGGCGGTGGATGCCGCGCAGCTTAACCTCGACTTCACCAAAGTGACCGCCCCTATTGACGGCCGCGCCAGCCGGGCGCTGATCACCAGCGGTAACCTGGTCACCGCGGGCGACACCGCCAGCGTGCTCACCACCCTGGTCTCGCAAAAGACGGTGTACGTCTACTTTGACGTCGACGAGTCAACCTACCTCCACTATCAAAACCTCGCCCGCCGCGGGCAAGGCGCGTCCAGCGATAATCAGGCGCTCCCGGTGGAGATTGGCCTGGTGGGCGAGGAGGGTTACCCCCACCAGGGCAAAGTGGATTTTCTCGATAATCAGTTAACGCCGAGTACCGGCACCATCCGCATGCGTGCGCTGCTGGATAACTCGCAGCGTCTGTTCACGCCGGGGCTGTTTGCCCGCGTGCGTCTGCCGGGCAGCGCAGAGTTCAAAGCCACGCTGATCGACGACAAAGCGGTACTGACCGATCAGGATCGTAAATACGTCTATATCGTTGATAAAGATGGTAAAGCACAGCGCCGCGACATTACCCCAGGGCGGCTGGCAGACGGTTTACGCATCGTTCAGAAGGGGTTGAATCCTGGGGATAGCGTCATCGTCGACGGCTTACAAAAAGTGTTTATGCCGGGTATGCCGGTTAACGCCAAAACCGTTGCCATGACCTCCAGCGCCACCCTTAACTGA", "partial": "0", "query_start": 86165, "query_end": 87292, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.9}, "gnl|BL_ORD_ID|1064|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "MexE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1067", "ARO_accession": "3000803", "ARO_name": "MexE", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.65455e-45, "max_identities": 125, "bit_score": 157.147, "cvterm_id": "36804", "query": "LMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELAD--GRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQ--EVASDD", "match": "L L+  L L+ C   P        P+V +  +   PL    E  GR  A    E+RP+VSG I +  F EG+ ++ G  L+QIDP  ++A     +  L +A+AA        +R ++L  +  IS +  D     AQ++ AAV A +A ++ AR+NL++T++T+PI GR+ ++ VT G LV +G+T  L T+   D +Y         FL+   ELA   GR  +      + L + DG   P  G L+F D  V+  TG+I  RA+F N      PG++VR +L       A L+  + V  T  G   V+V+   +K   R V     +    +V  GL  GDR++V GLQ+++PG+QV  Q  E+AS D", "sequence_from_db": "LALAAVLVLSACGKAPETTQGMAAPKVSVAEVIEQPLNEWDEFTGRLEAPESVELRPRVSGYIDRVAFHEGALVKKGDLLFQIDPRPFEAEVKRLEAQLQQARAAQARSVNEAQRGERLRASNAISAELADARTTAAQEAKAAVAATQAQLDAARLNLSFTRITAPIDGRVSRAEVTAGNLVNSGETL-LTTLVSTDKVYAYFDADERVFLKY-VELARQAGRDTRSESPVYLGLSSEDG--NPHLGRLDFLDNQVNPRTGTIRGRAVFDNAKGEFTPGLYVRLKLVGSKTYAATLIKDEAVG-TDLGKKFVLVLDGDNKTVYRTVEMGPKLEGLRIVRSGLSKGDRIVVNGLQRVRPGMQVDPQKVEMASAD", "sequence_from_broadstreet": "MEQSSHFSWRYPLALAAVLVLSACGKAPETTQGMAAPKVSVAEVIEQPLNEWDEFTGRLEAPESVELRPRVSGYIDRVAFHEGALVKKGDLLFQIDPRPFEAEVKRLEAQLQQARAAQARSVNEAQRGERLRASNAISAELADARTTAAQEAKAAVAATQAQLDAARLNLSFTRITAPIDGRVSRAEVTAGNLVNSGETLLTTLVSTDKVYAYFDADERVFLKYVELARQAGRDTRSESPVYLGLSSEDGNPHLGRLDFLDNQVNPRTGTIRGRAVFDNAKGEFTPGLYVRLKLVGSKTYAATLIKDEAVGTDLGKKFVLVLDGDNKTVYRTVEMGPKLEGLRIVRSGLSKGDRIVVNGLQRVRPGMQVDPQKVEMASADTLATLARLRQSVGDSEPPKVAASKDNATRNEPRG", "dna_sequence_from_broadstreet": "ATGGAACAGTCATCCCACTTCTCCTGGCGCTACCCCCTCGCACTCGCGGCCGTACTGGTCCTGAGCGCCTGCGGCAAGGCCCCGGAAACCACCCAAGGCATGGCGGCGCCCAAGGTCAGCGTCGCCGAAGTCATCGAACAACCGCTGAACGAGTGGGACGAATTCACCGGCCGCCTGGAGGCCCCGGAGTCGGTGGAGCTGCGCCCGCGGGTGTCGGGCTACATCGACCGCGTGGCCTTCCATGAAGGCGCACTGGTGAAGAAAGGCGACCTGCTGTTCCAGATCGACCCGCGCCCGTTCGAGGCCGAGGTCAAGCGCCTCGAAGCCCAGCTGCAACAGGCCCGCGCGGCCCAGGCGCGGAGCGTCAACGAAGCCCAGCGCGGCGAACGCCTGCGCGCCAGCAACGCGATCTCCGCGGAACTCGCCGACGCCCGCACCACCGCCGCCCAGGAAGCCAAGGCGGCGGTCGCCGCGACCCAGGCGCAACTGGACGCGGCGCGCCTGAACCTGAGCTTCACCCGGATCACCGCGCCGATCGACGGTCGCGTCAGCCGCGCCGAGGTCACCGCCGGCAACCTGGTCAACTCCGGGGAGACCCTGCTCACCACCCTGGTCAGCACCGACAAGGTCTACGCCTACTTCGACGCCGACGAGCGCGTGTTCCTCAAGTACGTCGAGCTGGCCCGCCAGGCCGGTCGCGACACGCGCAGCGAGAGCCCGGTGTACCTCGGCCTGAGCAGCGAGGACGGCAACCCGCACCTGGGCCGGCTGGACTTCCTCGACAACCAGGTCAACCCGCGTACCGGCACCATCCGCGGCCGCGCCGTGTTCGACAACGCCAAGGGCGAGTTCACCCCGGGCCTCTACGTGCGCCTGAAGCTGGTCGGCAGCAAGACCTACGCCGCCACCCTGATCAAGGACGAAGCGGTCGGCACCGACCTGGGCAAGAAGTTCGTGCTGGTCCTGGATGGCGACAACAAGACCGTCTACCGCACCGTCGAGATGGGACCGAAGCTGGAGGGCCTGCGCATCGTCCGCAGCGGCCTGAGCAAGGGCGACCGGATCGTCGTGAATGGCCTGCAGCGGGTCCGCCCGGGCATGCAGGTGGATCCGCAGAAGGTCGAGATGGCCAGCGCCGACACCCTGGCCACCCTCGCGCGCCTGCGGCAGTCGGTCGGCGACAGCGAACCACCGAAGGTGGCGGCGTCCAAGGACAACGCCACTCGCAACGAGCCGCGCGGCTGA", "partial": "0", "query_start": 86195, "query_end": 87301, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 33.51}, "gnl|BL_ORD_ID|2053|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexP", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2211", "ARO_accession": "3003698", "ARO_name": "mexP", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "37626": {"category_aro_accession": "3001227", "category_aro_cvterm_id": "37626", "category_aro_name": "kitasamycin", "category_aro_description": "Kitasamycin is a macrolide antibiotic and is produced by Streptoverticillium kitasatoense. The drug has antimicrobial activity against a wide spectrum of pathogens.", "category_aro_class_name": "Antibiotic"}, "40353": {"category_aro_accession": "3003701", "category_aro_cvterm_id": "40353", "category_aro_name": "rokitamycin", "category_aro_description": "Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.78268e-44, "max_identities": 119, "bit_score": 153.68, "cvterm_id": "36752", "query": "LTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELA--DGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQV", "match": "+ GC +      A   P V +  +   P+    E  G  +A    E+RP+V+G I      EG  ++ G  L+ IDP  ++A+ D+A+  L +A+AAA + +   +R + L   K ++++  D+A+A+   S A V AA+AA++ A+++L +T+VT+PI GR+G   VTEG  V NG  TAL ++  +DP+YV        +L   Q LA   GR  ++  + KV L+T++   Y +S  L+F     D+ TG++ +RA+  NPD  L PG+F + RLE G     +LV    +  T +G   V+VV EG+K + R V     +    +V  GL+ G+R++V GL  ++P +Q+", "sequence_from_db": "IAGCGESAPPGAASAPPSVPVAEVVVRPVTPYAEFTGSLTAVEQVELRPRVAGYIQDVTVPEGRLVEKGQQLFLIDPRVFKAAQDAARARLREAEAAALLARTEHERAELLYARKVVARERLDSAIASRNASKAQVDAARAALDAAQLDLGFTRVTAPIGGRVGHIQVTEGNYVTNG-VTALTSIVSVDPLYVYFDVDERTYL---QALAPTRGREGEQAPRVKVALLTDE--SYGRSSRLDFLANAADRGTGTVRVRAVVDNPDGQLTPGLFAKVRLETGKPRAQVLVADHSIG-TDQGRRYVLVVDEGNKTQYRPVELGPMVDGLRVVRQGLQPGERIVVKGL--VRPDMQI", "sequence_from_broadstreet": "MNLRHFIRITATLGVAALIAGCGESAPPGAASAPPSVPVAEVVVRPVTPYAEFTGSLTAVEQVELRPRVAGYIQDVTVPEGRLVEKGQQLFLIDPRVFKAAQDAARARLREAEAAALLARTEHERAELLYARKVVARERLDSAIASRNASKAQVDAARAALDAAQLDLGFTRVTAPIGGRVGHIQVTEGNYVTNGVTALTSIVSVDPLYVYFDVDERTYLQALAPTRGREGEQAPRVKVALLTDESYGRSSRLDFLANAADRGTGTVRVRAVVDNPDGQLTPGLFAKVRLETGKPRAQVLVADHSIGTDQGRRYVLVVDEGNKTQYRPVELGPMVDGLRVVRQGLQPGERIVVKGLVRPDMQITPRLAEIDGTPVDLSKTVGAAQ", "dna_sequence_from_broadstreet": "ATGAATCTCAGACACTTCATCCGCATCACCGCGACGCTAGGTGTCGCGGCCCTTATCGCTGGCTGCGGGGAATCGGCGCCGCCGGGGGCGGCGAGCGCCCCGCCAAGCGTTCCCGTCGCCGAGGTGGTGGTTCGCCCGGTGACACCCTACGCCGAGTTCACCGGCTCGCTGACCGCTGTCGAGCAGGTAGAACTGCGGCCGCGCGTCGCCGGCTACATCCAGGACGTTACGGTGCCGGAAGGCCGCCTGGTAGAGAAGGGCCAGCAACTGTTCCTCATCGACCCGCGCGTGTTCAAGGCGGCGCAGGATGCCGCCAGGGCACGCCTGCGCGAGGCCGAGGCCGCGGCGTTGCTGGCGCGCACCGAACACGAGCGAGCCGAGCTGCTGTATGCGCGGAAGGTCGTCGCCCGGGAGCGGCTCGACAGCGCCATCGCCTCGCGCAATGCCAGCAAGGCCCAGGTCGATGCGGCCAGGGCCGCCCTCGACGCGGCGCAACTGGATCTCGGCTTCACGCGGGTGACGGCACCGATCGGCGGGCGTGTCGGGCATATCCAGGTCACCGAGGGCAACTACGTCACCAATGGCGTCACCGCGCTGACCAGCATCGTTTCGGTCGATCCGCTGTACGTGTACTTCGATGTCGACGAGCGCACCTACCTGCAGGCCCTGGCGCCGACCCGCGGCAGGGAAGGCGAGCAGGCCCCCAGGGTCAAGGTGGCGCTGCTCACCGACGAGTCCTATGGACGAAGCAGTCGCCTCGATTTCCTCGCCAACGCCGCCGACCGCGGGACCGGCACGGTCCGGGTTCGGGCGGTGGTGGACAACCCGGACGGGCAACTGACGCCGGGGCTGTTCGCCAAGGTCAGGCTGGAGACCGGCAAGCCTCGCGCGCAGGTGCTGGTCGCCGACCATTCCATCGGCACCGACCAGGGCAGGCGCTATGTGCTGGTCGTCGACGAAGGCAACAAGACCCAGTACCGGCCGGTGGAACTCGGCCCGATGGTCGACGGCCTGCGGGTCGTCCGCCAGGGCCTGCAGCCGGGCGAGCGCATCGTCGTCAAGGGCCTGGTCCGGCCGGACATGCAGATCACACCGCGCCTTGCGGAAATCGATGGCACGCCCGTCGACCTGTCGAAGACCGTGGGGGCCGCACAATGA", "partial": "0", "query_start": 86219, "query_end": 87274, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 33.62}, "gnl|BL_ORD_ID|399|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdsA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "770", "model_id": "429", "ARO_accession": "3000789", "ARO_name": "mdsA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.55805e-40, "max_identities": 106, "bit_score": 143.28, "cvterm_id": "35734", "query": "SAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQN---GQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEV", "match": "S  L  T E  G  +A    E+R +V G +   +  EG  +  G  L+QIDP  ++ + D+A   L +A+  A   Q    R Q+L+ +  +S+++ D   AT     A + +AKAAV  AR+ L++T++T+PI+GR+ +  VT G LV     G  T L T+   +P+YV        +L+    L   R  +      + L T++GL Y   G L+F    ++++TG+I  RA+ P+PD  L PG+F R  L  G   + +L+    V+   +G   V++VG+ ++VE R V   Q +    +VT G+  G+++I+ GL  ++PG+ V  + V", "sequence_from_db": "SRTLAPTAEFTGFLAAPETVELRSRVGGTLDAISVPEGRLVSRGQLLFQIDPRPFEVALDTAVAQLRQAEVLARQAQADFDRIQRLVASGAVSRKNADDVTATRNARQAQMQSAKAAVAAARLELSWTRITAPIAGRVDRILVTRGNLVSGGVAGNATLLTTIVSHNPMYVYFDIDEATWLK---ALRHTRSDKNPPVVNMGLTTDNGLPY--QGVLDFMGNQMNRSTGTIRARAVIPDPDGMLSPGLFARISLPIGEPRETVLIDDLAVS-ADQGKNYVLIVGKENQVEYRPVELGQMVDGFRVVTQGVLPGEKIILKGL--VRPGMTVAPRLV", "sequence_from_broadstreet": "MRRTFKIMLIAGVIAAIGGVIYMAGEALWDKDNAVGPPASAPPPPSVPVAKALSRTLAPTAEFTGFLAAPETVELRSRVGGTLDAISVPEGRLVSRGQLLFQIDPRPFEVALDTAVAQLRQAEVLARQAQADFDRIQRLVASGAVSRKNADDVTATRNARQAQMQSAKAAVAAARLELSWTRITAPIAGRVDRILVTRGNLVSGGVAGNATLLTTIVSHNPMYVYFDIDEATWLKALRHTRSDKNPPVVNMGLTTDNGLPYQGVLDFMGNQMNRSTGTIRARAVIPDPDGMLSPGLFARISLPIGEPRETVLIDDLAVSADQGKNYVLIVGKENQVEYRPVELGQMVDGFRVVTQGVLPGEKIILKGLVRPGMTVAPRLVPMRQNVTDKQTATLTKADGDSAPKAVRQ", "dna_sequence_from_broadstreet": "ATGCGTAGAACATTCAAAATTATGTTGATAGCCGGCGTCATCGCCGCCATCGGGGGCGTGATTTACATGGCCGGCGAAGCACTATGGGATAAAGACAACGCCGTCGGCCCCCCGGCCAGCGCGCCGCCTCCACCGTCGGTACCGGTTGCTAAAGCCCTTAGCCGTACACTCGCGCCTACGGCGGAATTCACCGGTTTTCTGGCCGCGCCGGAAACCGTGGAGCTGCGTTCGCGCGTGGGAGGAACCCTTGACGCCATCAGCGTTCCGGAAGGACGTCTGGTAAGCCGCGGACAACTGCTGTTCCAGATCGATCCGCGCCCGTTCGAGGTCGCCCTCGACACCGCCGTCGCGCAATTACGTCAGGCTGAAGTACTGGCCCGCCAGGCGCAGGCGGATTTCGATCGCATTCAACGACTGGTCGCCAGCGGCGCCGTATCACGTAAAAACGCTGACGATGTCACCGCCACGCGTAATGCGCGACAGGCGCAGATGCAATCGGCCAAAGCCGCCGTCGCCGCAGCGCGCCTTGAACTCTCCTGGACCCGTATTACCGCGCCCATTGCCGGACGCGTTGACCGCATACTGGTGACCCGGGGCAATCTGGTCAGCGGCGGCGTAGCGGGTAACGCCACGCTTCTGACGACTATCGTGTCTCACAATCCCATGTATGTGTATTTCGATATTGACGAAGCCACCTGGCTGAAGGCGTTACGGCATACCCGCTCCGACAAAAATCCACCGGTAGTCAACATGGGGTTAACCACCGATAACGGGCTGCCTTATCAGGGCGTACTCGACTTTATGGGCAATCAGATGAACCGCAGCACCGGCACTATCCGGGCACGCGCCGTGATTCCTGACCCCGACGGAATGCTTTCTCCCGGCCTGTTTGCCCGAATCAGTTTGCCCATCGGCGAGCCGCGGGAAACCGTGCTGATTGACGATCTGGCGGTGAGCGCCGATCAGGGCAAAAACTATGTGCTGATCGTCGGCAAGGAGAATCAGGTGGAGTATCGTCCGGTTGAGTTGGGACAAATGGTCGATGGATTCCGCGTCGTTACACAGGGAGTACTGCCGGGAGAAAAAATCATCCTCAAGGGGCTGGTGCGTCCTGGCATGACCGTTGCGCCACGTCTGGTGCCGATGCGGCAGAATGTGACCGACAAACAGACCGCGACATTGACTAAAGCGGACGGCGACAGTGCGCCGAAGGCGGTGCGCCAATGA", "partial": "0", "query_start": 86294, "query_end": 87289, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 31.64}, "gnl|BL_ORD_ID|359|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdtA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "387", "ARO_accession": "3000792", "ARO_name": "mdtA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.8515e-37, "max_identities": 106, "bit_score": 135.961, "cvterm_id": "36849", "query": "AQQGAQHMPEVGIVTLKS---APLQITTELP----------GRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAK-VELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVAS", "match": "A + AQ  P  G   ++S   AP+Q  T +           G  +A     VR +V G ++  +F EG  ++AG  L +IDP+ ++ +   A+G LAK +A     +  + RYQ+L  T  +S+Q+ D   A   ++   + A +A+V +A++ L ++++T+P+ GR+G   V  G  + +G TT +  + Q  PI +  T   +D   + Q        Q+ GK   VE       K    GTL   D  +D TTG+I ++A F N D  L P  FV AR+      +A+++P   +     G   V V+   +KV    VT       K ++  G+ +GDRV+  G+ ++  G +V+  E  S", "sequence_from_db": "ATKQAQQSPAGGRRGMRSGPLAPVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLIALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTLPESDIATVVQ-------AQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGH-FVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQS", "sequence_from_broadstreet": "MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPAGGRRGMRSGPLAPVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLIALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTLPESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS", "dna_sequence_from_broadstreet": "ATGAAAGGTAGTTATAAATCCCGTTGGGTAATCGTAATCGTGGTGGTTATCGCCGCCATCGCCGCATTCTGGTTCTGGCAAGGCCGCAATGACTCCCGGAGTGCAGCCCCAGGGGCGACGAAACAAGCGCAGCAATCGCCAGCGGGTGGTCGACGTGGTATGCGTTCCGGCCCATTAGCCCCGGTTCAGGCGGCGACCGCCGTAGAACAGGCAGTTCCGCGTTACCTCACCGGGCTTGGCACCATTACCGCCGCTAATACCGTTACGGTGCGCAGCCGCGTGGACGGCCAACTGATAGCGTTACATTTCCAGGAAGGCCAGCAGGTCAAAGCAGGCGATTTACTGGCAGAAATTGACCCCAGCCAGTTCAAAGTTGCATTAGCACAAGCCCAGGGCCAACTGGCAAAAGATAAAGCCACGCTTGCCAACGCCCGCCGTGACCTGGCGCGTTATCAACAACTGGCAAAAACCAATCTCGTTTCCCGCCAGGAGCTGGATGCCCAACAGGCGCTGGTCAGTGAAACCGAAGGCACCATTAAGGCTGATGAAGCAAGCGTTGCCAGCGCGCAGCTGCAACTCGACTGGAGCCGGATTACCGCACCAGTCGATGGTCGCGTTGGTCTCAAGCAGGTTGATGTTGGTAACCAAATCTCCAGTGGTGATACCACCGGGATCGTGGTGATCACCCAGACGCATCCTATCGATTTAGTCTTTACCCTGCCGGAAAGCGATATCGCTACCGTAGTGCAGGCGCAGAAAGCCGGAAAACCGCTGGTGGTAGAAGCCTGGGATCGCACCAACTCGAAGAAATTAAGTGAAGGCACGCTGTTAAGTCTAGATAACCAAATCGATGCCACTACCGGTACGATTAAAGTGAAAGCACGCTTTAATAATCAGGATGATGCGCTGTTTCCCAATCAGTTTGTTAACGCGCGCATGTTAGTCGACACCGAACAAAACGCCGTAGTGATCCCAACAGCCGCCCTGCAAATGGGCAATGAAGGCCATTTTGTCTGGGTGCTGAATAGCGAAAACAAGGTCAGCAAACATCTGGTGACGCCGGGCATTCAGGACAGTCAGAAAGTGGTGATCCGTGCAGGTATTTCTGCGGGCGATCGCGTGGTGACAGACGGCATTGATCGCCTGACCGAAGGGGCGAAAGTGGAAGTGGTGGAAGCCCAGAGCGCCACTACTCCGGAAGAGAAAGCCACCAGCCGCGAATACGCGAAAAAAGGAGCACGCTCCTGA", "partial": "0", "query_start": 86243, "query_end": 87295, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 29.04}, "gnl|BL_ORD_ID|2066|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexM", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2216", "ARO_accession": "3003704", "ARO_name": "mexM", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.6917e-35, "max_identities": 101, "bit_score": 129.028, "cvterm_id": "36752", "query": "VRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQE", "match": "+R Q+ G + +    EG  ++AG  L  ID     A+ + A+   A  QA     +  ++RY+ L   + +S+Q  D   AT  Q  A + A  A +   R+ L+YT++TSP+SG++G   V  G LV+ G +  L +V Q+ PI V           L+QE          G+A V   + DG      G L   D  +D +TG+I +RA F N    L PG FV   L  G+  D L++  + V R   G+    V    D+VE   V   Q I D   V +GL SGD+V+V G  ++ PG  V  QE", "sequence_from_db": "IRTQIDGQLTRLLVSEGQMVEAGELLATIDDRAVVAALEQAQASRASNQAQLKSAEQDLQRYRSLYAERAVSRQLLDQQQATVDQLRATLKANDATINAERVRLSYTRITSPVSGKVGIRNVDVGNLVRVGDSLGLFSVTQIAPISV--------VFSLQQEQLLQLQALLGGEAAVRAYSRDGGSALGEGRLLTIDNQIDSSTGTIRVRASFDNRQARLWPGQFVAVSLHTGVRRDQLVLSSKAVRRGLEGNFVYRVA--DDRVEAVPVRVLQDI-DGLSVVEGLASGDQVVVDGHSRLMPGALVDIQE", "sequence_from_broadstreet": "MQALRSGGGRVLVGVLAAGLVAFGGWAWLGGDAGAKAAPAPARVPVIVARVERRDVEQQVSGIGTVTSLHNVVIRTQIDGQLTRLLVSEGQMVEAGELLATIDDRAVVAALEQAQASRASNQAQLKSAEQDLQRYRSLYAERAVSRQLLDQQQATVDQLRATLKANDATINAERVRLSYTRITSPVSGKVGIRNVDVGNLVRVGDSLGLFSVTQIAPISVVFSLQQEQLLQLQALLGGEAAVRAYSRDGGSALGEGRLLTIDNQIDSSTGTIRVRASFDNRQARLWPGQFVAVSLHTGVRRDQLVLSSKAVRRGLEGNFVYRVADDRVEAVPVRVLQDIDGLSVVEGLASGDQVVVDGHSRLMPGALVDIQEPRPSLAQATERRP", "dna_sequence_from_broadstreet": "ATGCAGGCGTTGCGCAGTGGTGGGGGACGGGTCCTGGTGGGCGTGCTGGCGGCGGGCCTGGTCGCCTTCGGCGGTTGGGCATGGCTCGGCGGCGACGCCGGGGCGAAGGCGGCGCCCGCGCCGGCCAGGGTCCCGGTGATCGTGGCGCGGGTGGAGCGGCGCGACGTCGAGCAACAGGTCAGCGGCATCGGCACGGTGACTTCGTTGCACAACGTGGTGATCCGCACCCAGATCGACGGCCAGTTGACCCGCCTGCTGGTGAGCGAAGGGCAGATGGTCGAGGCGGGCGAGTTACTGGCGACCATCGATGACCGCGCCGTCGTCGCCGCGCTGGAGCAGGCGCAGGCCTCCAGGGCGAGCAACCAGGCCCAGCTGAAATCCGCCGAGCAGGACCTGCAACGCTACCGCAGCCTGTATGCCGAGCGTGCGGTGTCACGCCAACTGCTGGACCAGCAGCAGGCGACGGTCGACCAGTTGCGCGCGACCCTGAAGGCCAACGATGCCACCATCAACGCCGAGCGGGTGCGCCTGTCCTACACCCGGATCACCTCGCCGGTATCCGGCAAGGTCGGTATCCGCAACGTCGATGTCGGCAACCTGGTGCGGGTCGGCGACAGTCTCGGCCTGTTCAGCGTGACCCAGATCGCACCGATCTCCGTAGTCTTCTCCCTGCAACAGGAACAGTTGCTCCAGTTGCAGGCGCTGCTCGGCGGCGAGGCGGCGGTGCGCGCCTACAGCCGCGACGGCGGGAGCGCGCTGGGCGAGGGCCGGTTGCTGACCATCGACAACCAGATCGACAGTTCCACCGGCACCATCCGCGTGCGCGCCTCCTTCGATAACCGCCAGGCCCGGCTCTGGCCCGGGCAGTTCGTCGCGGTGAGCCTGCACACCGGGGTCCGGCGCGACCAGTTGGTGCTGTCGAGCAAGGCGGTGCGCCGCGGCCTGGAGGGCAATTTCGTCTACCGGGTCGCCGACGACCGGGTCGAGGCGGTGCCGGTGCGGGTGCTCCAGGACATCGACGGCCTCAGTGTGGTGGAAGGCCTGGCCAGCGGTGACCAGGTGGTGGTGGACGGCCACTCGCGGCTGATGCCCGGCGCCCTGGTCGATATCCAGGAGCCGCGCCCGAGCCTGGCCCAGGCCACGGAGCGGCGGCCGTGA", "partial": "0", "query_start": 86357, "query_end": 87286, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 32.58}, "gnl|BL_ORD_ID|2063|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexV", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2207", "ARO_accession": "3003030", "ARO_name": "MexV", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.05141e-20, "max_identities": 100, "bit_score": 89.3521, "cvterm_id": "36804", "query": "TELP--GRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYP-QSGTLEFSDVT--VDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGE----------GDKVEVRQVTASQA--IGDKW----LVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQ", "match": "+ LP  G   A++   +  +VSG +    F+ G  ++    L Q++    +A+  +A+ DL  A+A         +R ++L+G+K IS+ ++D   A   +++A V   KAA       LA  +V +P +G IG   V  G  V  G  T +AT+Q L  + +D      DF  L               ++ +LV      YP Q    E + +   VD  T ++ +RA   NPD  LLPGMF    +        ++VP+  +T T  GD S+ VVG+           DK + +QV   +   IG++     +V +GL+ G++V+ +G  K+  G  V    VA  D QQ", "sequence_from_db": "SRLPAIGSLKAFQGVTLTAEVSGTVRDVLFLSGDQVKLDQPLIQLESDVEEATLRTAEADLGLARA-------EYQRGRELIGSKAISKSEFDRLAAQWAKTSATVAELKAA-------LAKKRVLAPFAGTIGIRQVDVGDYVSPG--TPIATLQDLSTLLLDFHLPEQDFPLL---------------SRGQLVKVRVAAYPAQVFDAEIAAINPKVDNETRNLQVRAALENPDGKLLPGMFANLEVMLPGEEQRVVVPETAITFTLYGD-SIYVVGQKKDEQGQVSKDDKGQPQQVVERRFVRIGERREGLAVVLEGLEGGEQVVTSGQLKLDNGAAVAI--VAERDLQQ", "sequence_from_broadstreet": "MLLRRMLIMLAAVIAVVAILAGYKVYSIRQQIALFSAPKPPISVTASLAEKRPWQSRLPAIGSLKAFQGVTLTAEVSGTVRDVLFLSGDQVKLDQPLIQLESDVEEATLRTAEADLGLARAEYQRGRELIGSKAISKSEFDRLAAQWAKTSATVAELKAALAKKRVLAPFAGTIGIRQVDVGDYVSPGTPIATLQDLSTLLLDFHLPEQDFPLLSRGQLVKVRVAAYPAQVFDAEIAAINPKVDNETRNLQVRAALENPDGKLLPGMFANLEVMLPGEEQRVVVPETAITFTLYGDSIYVVGQKKDEQGQVSKDDKGQPQQVVERRFVRIGERREGLAVVLEGLEGGEQVVTSGQLKLDNGAAVAIVAERDLQQEH", "dna_sequence_from_broadstreet": "ATGTTGCTCCGCCGCATGTTGATCATGCTCGCCGCGGTGATCGCCGTGGTGGCGATTCTCGCCGGCTACAAGGTCTACTCCATCCGTCAGCAGATCGCCCTTTTCAGCGCACCGAAACCGCCGATCAGCGTGACCGCCAGCCTGGCCGAAAAGCGTCCCTGGCAGAGCCGCCTGCCAGCCATCGGCAGCCTCAAGGCATTCCAGGGCGTGACCCTCACCGCCGAAGTCTCCGGCACGGTACGCGACGTACTGTTCCTTTCCGGCGACCAGGTGAAGCTGGACCAACCGCTGATCCAGTTGGAAAGCGACGTCGAGGAAGCCACCCTGCGCACTGCCGAGGCCGATCTCGGCCTGGCCAGGGCCGAGTACCAGCGCGGCCGCGAACTGATCGGCAGCAAGGCCATCTCGAAAAGCGAATTCGATCGTCTCGCCGCGCAGTGGGCCAAGACCAGCGCCACCGTCGCCGAGCTGAAGGCGGCGCTGGCGAAGAAGCGCGTGCTCGCGCCCTTCGCCGGGACCATCGGCATCCGCCAGGTGGACGTCGGCGACTACGTCTCGCCCGGGACGCCGATCGCCACCTTGCAGGACCTTTCCACCCTGCTCCTGGATTTCCACCTGCCCGAGCAGGACTTCCCCCTGCTCAGCCGCGGCCAACTGGTGAAGGTCCGGGTCGCCGCCTACCCCGCCCAGGTGTTCGACGCCGAGATCGCCGCCATCAACCCCAAGGTCGACAACGAGACCCGCAACCTGCAGGTCCGCGCTGCCCTGGAGAACCCGGACGGCAAGCTGCTGCCGGGCATGTTCGCCAACCTCGAGGTGATGTTGCCTGGCGAGGAACAACGCGTCGTGGTCCCGGAGACGGCGATCACCTTCACCCTCTACGGCGACTCGATCTACGTCGTCGGGCAGAAGAAGGACGAGCAGGGCCAGGTGTCGAAGGATGACAAGGGCCAGCCGCAACAGGTCGTCGAGCGCCGCTTCGTCAGGATCGGCGAACGCCGCGAAGGCCTGGCGGTGGTGCTCGAAGGCCTTGAGGGCGGCGAGCAGGTAGTGACTTCCGGGCAACTGAAGCTCGACAACGGCGCCGCGGTGGCCATCGTCGCCGAGCGGGACCTCCAGCAAGAGCACTGA", "partial": "0", "query_start": 86315, "query_end": 87310, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 28.33}, "gnl|BL_ORD_ID|2049|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "TriB", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "2193", "ARO_accession": "3003680", "ARO_name": "TriB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.40296e-14, "max_identities": 97, "bit_score": 70.0922, "cvterm_id": "36804", "query": "LTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQ---SGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLE-----EGINPDALLVPQQGVTRTPRGDASVMVV-GEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVA", "match": "+ P ++  +   +L L+GC D+P     + +  V + TLK+  L       G   A   + +  + +G I  R F  G  +  G  L  +DP   Q    +++GDLA A+A     Q   +R ++L      +Q   D A    + S A+   AKAAV+ AR  L+YT++ +   G I       G +V  GQ    A V    P   +V ++  D   L  E+A      E+  A    + +  L  PQ   +G++       D +T +  +R            G  ++ +L        + P ++L+ + G T+       V VV G+   V +R+V        + ++  GL  GDRV+  G+  +KPG ++K  E A", "sequence_from_db": "MKPFSLAGLFGFALLLSGCGDEPPPAPPRPVLTVTVKTLKNDDL---GRFAGSIQARYESVLGFRTNGRIASRLFDVGDFVGKGALLATLDPTDQQNQLRASQGDLASAEAQLIDAQANARRQEELFARSVTAQARLDDARTRLKTSQASFDQAKAAVQQARDQLSYTRLVTDFDGVITTWHAEAGQVVSAGQ----AVVTLARP---EVREAVFD---LPTEVA------ESLPADARFLVSAQLD-PQARTTGSIRELGPQADASTRTRRVRLSLAQTPEAFRLGSTIQVQLSSAGSVRSVLPASVLLERDGKTQ-------VWVVDGKQSSVALREVQVLSRDERQVVIGQGLADGDRVVRAGVNSLKPGQKIKLDEDA", "sequence_from_broadstreet": "MKPFSLAGLFGFALLLSGCGDEPPPAPPRPVLTVTVKTLKNDDLGRFAGSIQARYESVLGFRTNGRIASRLFDVGDFVGKGALLATLDPTDQQNQLRASQGDLASAEAQLIDAQANARRQEELFARSVTAQARLDDARTRLKTSQASFDQAKAAVQQARDQLSYTRLVTDFDGVITTWHAEAGQVVSAGQAVVTLARPEVREAVFDLPTEVAESLPADARFLVSAQLDPQARTTGSIRELGPQADASTRTRRVRLSLAQTPEAFRLGSTIQVQLSSAGSVRSVLPASVLLERDGKTQVWVVDGKQSSVALREVQVLSRDERQVVIGQGLADGDRVVRAGVNSLKPGQKIKLDEDAR", "dna_sequence_from_broadstreet": "ATGAAGCCGTTTTCCCTCGCCGGCCTGTTCGGCTTCGCCCTGCTCCTCTCCGGCTGCGGCGACGAGCCGCCGCCGGCACCGCCGCGGCCGGTGCTGACGGTGACCGTGAAGACCCTGAAGAACGACGACCTCGGTCGCTTCGCCGGGAGCATCCAGGCGCGCTACGAGAGCGTGCTCGGCTTCCGCACCAACGGACGGATCGCCTCGCGCCTGTTCGACGTCGGTGACTTCGTCGGCAAGGGCGCGCTGCTGGCGACCCTCGACCCCACCGACCAGCAGAACCAGTTGCGCGCCAGCCAGGGCGACCTGGCCAGCGCCGAGGCACAGTTGATCGACGCCCAGGCCAATGCCCGGCGCCAGGAAGAACTGTTCGCCCGCAGCGTCACCGCCCAGGCGCGCCTGGACGATGCGCGGACCCGCCTGAAGACCAGCCAGGCCAGCTTCGACCAGGCCAAAGCGGCGGTGCAGCAGGCCAGGGACCAGCTTTCCTACACGCGCCTGGTGACCGATTTCGACGGCGTCATCACCACCTGGCACGCCGAGGCCGGGCAAGTGGTCAGCGCCGGCCAGGCGGTGGTCACCCTGGCCCGGCCCGAAGTGCGCGAGGCAGTCTTCGACCTGCCCACCGAGGTCGCCGAGAGCCTGCCGGCCGACGCGCGCTTCCTGGTCAGCGCCCAGCTCGACCCGCAGGCCAGGACCACCGGCAGCATCCGCGAGCTGGGTCCGCAGGCCGACGCCTCGACCCGCACCCGTCGCGTGCGCCTGAGCCTGGCGCAGACGCCGGAGGCGTTTCGCCTCGGTTCGACCATCCAGGTCCAGCTGAGCAGCGCCGGTAGCGTGCGCAGCGTGCTGCCGGCCAGCGTGCTGCTGGAGCGCGACGGCAAGACCCAGGTCTGGGTCGTCGATGGGAAACAGTCCAGCGTGGCCCTGCGCGAGGTACAGGTGCTCAGCCGCGACGAACGCCAGGTGGTGATCGGACAGGGCCTGGCCGACGGCGACCGGGTGGTCCGCGCCGGAGTCAACAGCCTCAAGCCCGGCCAGAAGATCAAACTCGACGAGGATGCGCGATGA", "partial": "0", "query_start": 86174, "query_end": 87292, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 25.39}, "gnl|BL_ORD_ID|1620|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "ceoA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "730", "model_id": "1719", "ARO_accession": "3003009", "ARO_name": "ceoA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.56212e-12, "max_identities": 49, "bit_score": 62.7734, "cvterm_id": "36822", "query": "LAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQS", "match": "LAVV +  G+           ++ A  +PEV + T+    +       GR  A    +VRPQVSG I+  NF +G+ ++ G  L+ IDP  YQA  D A   LA AQA     Q   +R Q+L+G   I+++DYD     A+++", "sequence_from_db": "LAVVGL--GTFGAMRVSANAPEKAAAPLPEVDVATVVPQTVTDWQSYSGRLEAVEKVDVRPQVSGTIVAVNFKDGALVKKGDVLFVIDPRPYQAEVDRAAAQLAAAQARNGYAQTDWQRAQRLIGDNAIAKRDYDEKQNAAREA", "sequence_from_broadstreet": "MAILRTSRSRIATAAIVTLAVVGLGTFGAMRVSANAPEKAAAPLPEVDVATVVPQTVTDWQSYSGRLEAVEKVDVRPQVSGTIVAVNFKDGALVKKGDVLFVIDPRPYQAEVDRAAAQLAAAQARNGYAQTDWQRAQRLIGDNAIAKRDYDEKQNAAREAKREPEGRRSRAGNGAHQSRLYAHHRAGVGPRVARGNHARQRRVGRRVGRAADDAGIGVADLRVVRRRRADLPAIHQRRAQRPQGAGRARPRERNRLLAQRRDRFGRQPARHVVRHDPRARPLRQRGRHPGPGPLRTREGGRQRAARGAARRRRGDQHRPGQEVRVRRRPAGPRVVSRSAARDAARQPARDRERAVGRRPRGRERHAARASGRAGEAAHGPDDGRRCAVRAVASTAKPAAPAKADS", "dna_sequence_from_broadstreet": "ATGGCCATCCTACGCACCTCCCGTTCCCGAATCGCGACCGCGGCGATCGTCACGCTCGCCGTCGTCGGCCTCGGCACGTTCGGCGCGATGCGCGTGAGCGCGAACGCCCCCGAGAAAGCGGCGGCGCCGCTGCCCGAAGTCGACGTCGCGACCGTCGTGCCGCAGACCGTGACCGACTGGCAAAGCTATTCGGGCCGCCTCGAGGCGGTCGAGAAAGTCGACGTGCGCCCGCAGGTGTCGGGCACGATCGTCGCGGTGAACTTCAAGGACGGCGCGCTCGTGAAGAAAGGCGACGTGCTGTTCGTGATCGACCCGCGCCCGTACCAGGCGGAAGTCGACCGCGCCGCCGCGCAGCTCGCGGCCGCGCAGGCCCGCAACGGCTACGCGCAGACCGACTGGCAGCGCGCGCAGCGGCTGATCGGCGACAACGCGATCGCGAAGCGCGACTACGACGAGAAGCAGAACGCGGCGCGCGAAGCGAAACGCGAACCTGAAGGCCGCCGAAGCCGCGCTGGAAACGGCGCGCATCAATCTCGGCTATACGCGCATCACCGCGCCGGTGTCGGGCCGCGTGTCGCGCGCGGAAATCACGCTCGGCAACGTCGTGTCGGCCGGCGCGTCGGCCGCGCCGCTGACGACGCTGGTATCGGTGTCGCCGATCTACGCGTCGTTCGACGCCGACGAGCAGACCTACCTGCAATACATCAACGGCGCGCGCAGCGGCCGCAAGGTGCCGGTCGAGCTCGGCCTCGCGAACGAAACCGGCTACTCGCGCAGCGGCGAGATCGATTCGGTCGACAACCGGCTCGACACGTCGTCCGGCACGATCCGCGTGCGCGCCCGCTTCGACAACGCGGACGGCACCCTGGTCCCGGGCCTCTACGCACGCGTGAAGGTGGGCGGCAGCGCGCCGCACGAGGCGCTGCTCGTCGACGACGCGGCGATCAACACCGACCAGGACAAGAAGTTCGTGTTCGTCGTCGACCAGCAGGGCCGCGTGTCGTATCGCGAAGTGCAGCAAGGGATGCAGCACGGCAACCGGCGCGTGATCGTGAGCGGGCTGTCGGCCGGCGACCGCGTGGTCGTGAACGGCACGCAGCGCGTGCGTCCGGGCGAGCAGGTGAAGCCGCACATGGTCCCGATGACGGGCGGCGATGCGCCGTCCGCGCCGTCGCGAGCACCGCGAAGCCGGCCGCACCGGCGAAGGCGGATTCGTAA", "partial": "0", "query_start": 86183, "query_end": 86614, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 34.03}, "gnl|BL_ORD_ID|2048|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "TriA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2192", "ARO_accession": "3003679", "ARO_name": "TriA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.26143e-11, "max_identities": 89, "bit_score": 62.003, "cvterm_id": "36804", "query": "LAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPIS----------GRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLE----FSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPG", "match": "+A+  +L   L L GC  +P    A+    V   T+K A     T + G   A   A+   +V G I++R    G  + AG  L ++DP   +++ ++A+  +A  QA + +  L  +R + LL   Y SQ +YD A+A+ + + +++ AA+A +  AR  L+YT++ +  +          G++ ++TV    L ++G+  A+  V      Y  +     D  R+   L        +GK +    T D     +SGTL+       V  + + GS+   ++    +H+++      +++ E   P   L+ QQG                  K  ++ V  ++   +K ++  GL++G  V+  G Q + PG", "sequence_from_db": "MALPAILCAGL-LVGCGAEPP---AEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNV------YESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVD----ERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVLPWSALSKVGE--QPAVWLLDQQG------------------KARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPG", "sequence_from_broadstreet": "MSDARGAFHSKGRWSRMALPAILCAGLLVGCGAEPPAEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVLPWSALSKVGEQPAVWLLDQQGKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQPPQPTQSTASRDAVGGGQP", "dna_sequence_from_broadstreet": "ATGTCAGACGCCAGAGGCGCTTTTCATTCCAAAGGTCGCTGGTCGCGGATGGCGCTGCCCGCCATCCTGTGCGCCGGCCTGCTTGTCGGTTGCGGCGCCGAGCCGCCCGCCGAGGAACACGTCCGTGTGCTGGCGCAGACGGTGAAGATGGCCGAGTTCGCCTCGGCCACCTCGATCACCGGCGACATCCAGGCACGGGTACAGGCCGACCAGTCGTTCCGTGTCGGCGGCAAGATCGTCGAGCGCCTGGTCGATGTCGGCGACCACGTCGCGGCTGGCCAGGTGCTGGCGCGGCTCGACCCGCAGGACCAGCGCAGCAACGTGGAGAACGCCCAGGCGGCGGTCGCCGCGCAGCAGGCGCAGTCGAAGCTCGCCGACCTCAACTACCAGCGGCAGAAGGCGCTGCTGCCCAAGGGCTACACCAGCCAGAGCGAGTACGACCAGGCGCTGGCCTCGGTGCGCAGCGCGCAGAGTTCGCTGAAGGCCGCCCAGGCGCAGTTGGCCAACGCCCGCGACCTGCTTTCCTATACCGAGCTGCGTGCCTCCGACGCCGGGGTCATCACCGCCCGCCAGGCCGAGGTCGGCCAGGTGGTGCAGGCCACCGTGCCGATCTTCACCCTGGCCCGCGACGGCGAGCGCGACGCGGTGTTCAACGTCTACGAGTCGTTGTTCAGCCACGATGTCGACGGCCAGCGGATCACCGTCAGCCTGCTCGGCAAGCCGGAAGTCACCGCCAGCGGCAAGGTCCGCGAGATCACCCCCACGGTGGACGAGCGCAGCGGTACGCTGAAGGTCAAGGTCGGCCTCGACTCGGTGCCGGCGGAAATGAGCCTCGGCAGCGTGGTCAACGCCAGCGTCGCCGCGCCGGCCGAGCACAGCGTGGTGCTGCCCTGGTCGGCGCTGTCCAAGGTCGGCGAGCAGCCGGCGGTCTGGTTGCTCGACCAGCAAGGCAAGGCGCGTCTGCAACCGGTGCGGGTGGCACGCTACGCCAGCGAGAAGGTGGTCATCGACGGTGGCCTGGAGGCGGGCCAGACGGTGGTCACGGTGGGCGGCCAACTGCTCCATCCGGGCCAGGTGGTCGAGGTGGCCCAGCCGCCGCAGCCGACCCAGAGCACCGCCAGCCGCGACGCCGTGGGCGGAGGCCAGCCATGA", "partial": "0", "query_start": 86183, "query_end": 87265, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 23.73}, "gnl|BL_ORD_ID|2061|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexJ", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "690", "model_id": "2205", "ARO_accession": "3003692", "ARO_name": "MexJ", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.33857e-11, "max_identities": 83, "bit_score": 60.077, "cvterm_id": "36804", "query": "PLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQ-VTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVK", "match": "PL V L L  SL L  C +      A       IV       +++   PG   A    E+  ++ G +++R    G  ++    L ++DP   +   ++A+  ++ A+A     +   +RY+ LL    +S   ++    + +   A +   +A    A     Y  + SP  G I    V  G +V  GQT           + + + + S +  R+ Q ++            VEL +    ++  +G +       D  + +   R  F +       G   R  +        L VP   +T    G A V VV  G     RQ V       D+  V +GLK+GD V+ TG+Q ++ G QV+", "sequence_from_db": "PL-VALSLFSSLFLAACGNGTPPPAAARP---AIVVQPQPAGEVSQAFPGEIRARHEPELAFRIGGKVIRRLVEVGERVKKDQPLAELDPQDVRLQLEAARAQVSAAEANLQTVRAEYRRYRTLLDRNLVSHSQFENIQNSYRAGEARLKQIRAEFNVADNQAGYAVLRSPQDGVIASRRVEVGQVVAAGQTVFSLAADGEREVLIGLPEHSFERFRIGQPVS------------VELWSQRDRRF--AGHIRELSPAADPQSRTFAARVAFDDRATPAELGQSARVYV-AAAEAVPLSVPLSALT-AEAGQAFVWVVEPGSSTLRRQAVRTGPYAEDRVPVLEGLKAGDWVVATGVQVLREGQQVR", "sequence_from_broadstreet": "MYRHIPLVALSLFSSLFLAACGNGTPPPAAARPAIVVQPQPAGEVSQAFPGEIRARHEPELAFRIGGKVIRRLVEVGERVKKDQPLAELDPQDVRLQLEAARAQVSAAEANLQTVRAEYRRYRTLLDRNLVSHSQFENIQNSYRAGEARLKQIRAEFNVADNQAGYAVLRSPQDGVIASRRVEVGQVVAAGQTVFSLAADGEREVLIGLPEHSFERFRIGQPVSVELWSQRDRRFAGHIRELSPAADPQSRTFAARVAFDDRATPAELGQSARVYVAAAEAVPLSVPLSALTAEAGQAFVWVVEPGSSTLRRQAVRTGPYAEDRVPVLEGLKAGDWVVATGVQVLREGQQVRPIDRANRTVKLAAKE", "dna_sequence_from_broadstreet": "ATGTACCGCCATATCCCGCTCGTCGCCCTGTCCCTGTTTTCCTCCCTGTTCCTCGCCGCCTGCGGCAACGGCACGCCGCCGCCAGCCGCGGCGCGTCCGGCGATCGTCGTCCAGCCCCAGCCGGCGGGGGAGGTGAGCCAGGCCTTTCCCGGCGAGATCCGCGCCCGCCACGAGCCGGAGCTGGCCTTCCGCATCGGCGGCAAGGTCATCCGCCGGCTGGTGGAAGTCGGCGAGCGGGTAAAGAAGGACCAGCCCCTGGCCGAACTCGATCCCCAGGACGTGCGCCTGCAACTGGAGGCGGCGCGGGCCCAGGTCAGTGCCGCCGAGGCCAACTTGCAGACCGTGCGCGCCGAGTACCGGCGCTACCGCACCTTGCTCGACCGCAACCTGGTCAGCCATTCCCAGTTCGAGAACATCCAGAACAGCTACCGCGCCGGCGAGGCGCGGCTGAAGCAGATCCGCGCCGAATTCAACGTCGCCGACAACCAGGCCGGCTACGCCGTGCTGCGCTCGCCCCAGGATGGCGTGATCGCCAGCCGGCGCGTCGAGGTGGGCCAGGTGGTGGCGGCCGGACAGACGGTCTTCAGCCTGGCCGCCGACGGCGAACGCGAGGTGCTGATCGGCCTGCCGGAACACAGCTTCGAACGTTTCCGCATCGGCCAGCCGGTGTCGGTCGAACTCTGGTCGCAACGCGACAGACGCTTCGCCGGGCATATCCGCGAGCTCTCGCCCGCGGCCGATCCGCAATCGCGTACCTTCGCCGCCCGGGTGGCCTTCGACGACCGCGCGACTCCGGCCGAACTGGGCCAGAGCGCGCGGGTCTACGTCGCCGCCGCCGAGGCGGTGCCGTTATCGGTTCCCTTGTCGGCGCTGACCGCAGAGGCCGGCCAGGCGTTCGTCTGGGTGGTCGAGCCGGGCAGCTCGACCCTGCGCCGGCAGGCGGTGCGCACCGGTCCCTATGCCGAGGACCGGGTGCCGGTGCTCGAAGGCCTGAAGGCTGGCGACTGGGTGGTGGCCACCGGGGTCCAGGTGCTTCGCGAAGGGCAGCAGGTGCGTCCGATCGACCGGGCCAACCGCACGGTGAAACTGGCGGCCAAGGAGTAG", "partial": "0", "query_start": 86180, "query_end": 87277, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 22.62}, "gnl|BL_ORD_ID|1584|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "macA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "760", "model_id": "1680", "ARO_accession": "3000533", "ARO_name": "macA", "ARO_category": {"36002": {"category_aro_accession": "0010001", "category_aro_cvterm_id": "36002", "category_aro_name": "ATP-binding cassette (ABC) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45684e-10, "max_identities": 83, "bit_score": 58.5362, "cvterm_id": "36806", "query": "TLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTV----KRYQK---LLGTKYISQQDYDTAVATAQ-------QSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTT-ALATVQQLDPIYVDVTQSSNDFLRLK--QELADGRLKQENGKAKVELVTND-GLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLE-EGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVT", "match": "T++   +  T    G  S   +  V  Q SG I K     G  ++ G  + +I+  T   + +  K  L   QA     Q+ +    K+Y++   L      S++D ++A            +  A +  +K ++ TA  +L YT++T+ + G +    V EG  V   Q+T  +  +  LD +   +  +  D  ++K  Q+++   L + +   K +L + D GL    SG    S  T          R+  PNPD  L  GM  +  +E +G+  + LL+P   V +   G A V V+G   K   R++           V  GLK GD+V+++", "sequence_from_db": "TVRRGGISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVKKGDLIAEINSTTQTNTLNMEKSKLETYQAKLVSAQIALGSAEKKYKRQTALWKDDATSKEDLESAQDALAAAKANVAELKALIRQSKISINTAESDLGYTRITATMDGTVVAIPVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAV-YYYARSFVPNPDGKLATGMTTQNTVEIDGVK-NVLLIPSLTV-KNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVIS", "sequence_from_broadstreet": "MAKMMKWSAVAAVAAAAVWGGWHYLKPEPQAAYITETVRRGGISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVKKGDLIAEINSTTQTNTLNMEKSKLETYQAKLVSAQIALGSAEKKYKRQTALWKDDATSKEDLESAQDALAAAKANVAELKALIRQSKISINTAESDLGYTRITATMDGTVVAIPVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLLIPSLTVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGGPPRR", "dna_sequence_from_broadstreet": "ATGGCGAAAATGATGAAATGGTCGGCTGTTGCGGCAGTCGCGGCGGCAGCGGTTTGGGGCGGATGGCATTATCTGAAGCCCGAACCGCAGGCTGCTTATATTACGGAAACGGTCAGGCGCGGCGGCATCAGCCGGACGGTTTCCGCGACGGGCGAGATTTCGCCGTCGAATCTGGTATCGGTCGGCGCGCAGGCTTCGGGGCAGATTAAAAAGCTTTATGTCAAACTCGGGCAACAGGTCAAAAAGGGAGATTTGATTGCGGAAATCAATTCGACCACGCAGACCAACACGCTCAATATGGAAAAATCTAAATTGGAAACGTATCAGGCGAAGCTGGTGTCGGCACAGATTGCATTGGGCAGCGCGGAGAAGAAATATAAGCGTCAGACGGCGTTGTGGAAGGATGATGCGACCTCTAAAGAAGATTTGGAAAGCGCGCAGGATGCGCTTGCCGCCGCCAAAGCCAATGTTGCCGAGTTGAAGGCTTTAATCAGACAGAGCAAAATTTCCATCAATACCGCCGAGTCGGATTTGGGCTACACGCGCATTACCGCGACGATGGACGGCACGGTGGTGGCGATTCCCGTGGAAGAGGGGCAAACCGTGAACGCGGCGCAGTCTACGCCGACGATTGTCCAATTGGCGAATCTGGATATGATGTTGAACAAAATGCAGATTGCCGAGGGCGATATTACCAAGGTGAAGGCGGGGCAGGATATTTCGTTTACGATTTTGTCCGAACCGGATACGCCGATTAAGGCGAAGCTCGACAGCGTCGACCCCGGGCTGACCACGATGTCGTCGGGCGGCTACAACAGCAGTACGGATACGGCTTCCAATGCGGTCTATTATTATGCCCGTTCGTTTGTGCCGAATCCGGACGGCAAACTCGCCACGGGGATGACGACGCAGAATACGGTTGAAATCGACGGTGTGAAAAATGTGTTGCTTATTCCGTCGCTGACCGTGAAAAATCGCGGCGGCAAGGCGTTCGTACGCGTGTTGGGTGCGGACGGCAAGGCGGCGGAACGCGAAATCCGGACCGGTATGAGAGACAGTATGAATACCGAAGTGAAAAGCGGGTTGAAAGAGGGGGACAAAGTGGTCATCTCCGAAATAACCGCCGCCGAGCAGCAGGAAAGCGGCGAACGCGCCCTAGGCGGCCCGCCGCGCCGATAA", "partial": "0", "query_start": 86285, "query_end": 87241, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 24.56}, "gnl|BL_ORD_ID|1263|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mexH", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "1344", "ARO_accession": "3000807", "ARO_name": "MexH", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.17017e-09, "max_identities": 65, "bit_score": 53.9138, "cvterm_id": "36804", "query": "KGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTA-LATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTG---SITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDK-VEVRQVTASQAIGDKW----LVTDGLKSGDRVIVTGLQKIKPGVQVK", "match": "+ +L + +A     ++   R +KL+     SQ+  D AVA    +  AV   +A ++   I        +P SG++G   V  G  +   +  A L   + L   +  + +S++  L+L Q L            +V +    G  +P   +       +D   G   ++ ++A+  NP+  L  GMF   R+    +  +L VP+  VT T  GD   +   +GD+ +  ++V+    IG++W     +  GL  GDRV+ +G   +  G+ V+", "sequence_from_db": "QAELIRLKAQLRNAEILHARARKLVERNVASQEQLDNAVAARDMALGAVRQTQALIDQKAIR-------APFSGQLGIRRVHLGQYLGVAEPVASLVDARTLKSNF-SLDESTSPELKLGQPL------------EVLVDAYPGRSFPARIS------AIDPLIGKSRTVQVQALLDNPEGLLAAGMFASIRVSRKADAPSLSVPETAVTYTAYGDTVFVAHQDGDRPLSAKRVSVR--IGERWDGRVEILQGLAEGDRVVTSGQINLSDGMAVE", "sequence_from_broadstreet": "MQKPVLIASAALICAAVIGIAVYATGSAKKDAGGFAGYPPVKVALASVERRVVPRVFDGVGELEAGRQVQVAAEAAGRITRIAFESGQQVQQGQLLVQLNDAVEQAELIRLKAQLRNAEILHARARKLVERNVASQEQLDNAVAARDMALGAVRQTQALIDQKAIRAPFSGQLGIRRVHLGQYLGVAEPVASLVDARTLKSNFSLDESTSPELKLGQPLEVLVDAYPGRSFPARISAIDPLIGKSRTVQVQALLDNPEGLLAAGMFASIRVSRKADAPSLSVPETAVTYTAYGDTVFVAHQDGDRPLSAKRVSVRIGERWDGRVEILQGLAEGDRVVTSGQINLSDGMAVEPVKEDTLSSAAPPVPVAGR", "dna_sequence_from_broadstreet": "ATGCAGAAACCCGTCCTGATCGCCAGTGCCGCGCTCATCTGCGCGGCGGTTATCGGCATCGCCGTCTACGCCACCGGCTCGGCGAAGAAAGACGCCGGCGGTTTCGCCGGCTACCCGCCGGTGAAGGTCGCCCTCGCCTCGGTGGAGCGGCGGGTGGTGCCGCGCGTCTTCGATGGCGTCGGCGAGCTGGAGGCCGGTCGCCAGGTCCAGGTGGCCGCCGAAGCGGCAGGACGGATCACCCGCATCGCCTTCGAATCGGGCCAGCAGGTGCAGCAAGGGCAGTTGCTGGTGCAACTCAACGACGCGGTGGAACAGGCCGAGCTGATCCGTCTCAAGGCGCAGTTGCGCAATGCCGAGATCCTCCATGCCCGTGCGCGCAAGCTGGTAGAGCGCAACGTCGCCTCGCAGGAACAGCTGGACAACGCCGTCGCCGCCCGCGACATGGCGCTCGGCGCGGTGCGCCAGACCCAGGCGCTGATCGACCAGAAGGCGATCCGCGCGCCCTTCTCCGGCCAGCTCGGCATCCGCCGCGTGCACCTCGGCCAGTACCTCGGCGTCGCCGAGCCGGTGGCCAGCCTGGTGGATGCGCGGACCCTGAAAAGCAATTTCTCCCTGGACGAAAGCACCAGTCCCGAGCTGAAGCTCGGCCAGCCCCTCGAGGTCCTGGTCGACGCCTATCCGGGGCGCAGCTTCCCGGCGCGCATCAGCGCCATCGACCCGCTGATCGGCAAGTCGCGCACGGTGCAGGTCCAGGCCTTGCTGGACAACCCCGAAGGCCTGCTCGCCGCCGGCATGTTCGCCAGCATCCGGGTCTCGCGCAAAGCCGACGCGCCGTCGCTGAGCGTGCCGGAAACCGCGGTCACCTATACCGCCTACGGCGACACCGTGTTCGTCGCCCACCAGGACGGCGACCGGCCGCTCAGCGCCAAGCGCGTCTCGGTGCGGATCGGCGAGCGCTGGGACGGTCGCGTGGAAATCCTCCAGGGCCTCGCCGAGGGCGACCGGGTAGTGACTTCCGGACAGATCAACCTGAGCGACGGGATGGCCGTGGAACCGGTCAAGGAAGACACCCTGAGCAGTGCCGCGCCCCCCGTGCCGGTCGCCGGCCGCTGA", "partial": "0", "query_start": 86480, "query_end": 87277, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 23.64}, "gnl|BL_ORD_ID|1354|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "mdtN", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "1442", "ARO_accession": "3003548", "ARO_name": "mdtN", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35963": {"category_aro_accession": "0000045", "category_aro_cvterm_id": "35963", "category_aro_name": "acriflavine", "category_aro_description": "Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish.", "category_aro_class_name": "Antibiotic"}, "35965": {"category_aro_accession": "0000047", "category_aro_cvterm_id": "35965", "category_aro_name": "puromycin", "category_aro_description": "Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, that causes premature chain termination during ribosomal protein translation.", "category_aro_class_name": "Antibiotic"}, "36174": {"category_aro_accession": "3000034", "category_aro_cvterm_id": "36174", "category_aro_name": "nucleoside antibiotic", "category_aro_description": "Nucleoside antibiotics are made of modified nucleosides and nucleotides with wide-ranging activities and means of antibacterial effects. This drug class includes aminonucleoside antibiotics, which contain an amino group.", "category_aro_class_name": "Drug Class"}, "36193": {"category_aro_accession": "3000054", "category_aro_cvterm_id": "36193", "category_aro_name": "acridine dye", "category_aro_description": "Acridine dyes are cell permeable, basic molecules with an acridine chromophore. These compounds intercalate DNA. The image shown represents the core structure of the acridine family, with specific dyes containing varying substituents.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.02562e-06, "max_identities": 50, "bit_score": 44.669, "cvterm_id": "36839", "query": "PGRTSAYRIAE---VRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLA----------------------------KAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQS-----NA----------------AVVAAKAAVET----ARINLAYTKVTSPISGRI", "match": "P    AY  A+   V P+VSG I++    +   ++ G  L++IDP  Y+A+   A+  LA                            KA+AAA     T++R + LL   ++S +D D A  TAQ++     NA                A+VA +AAVE      +++L    V +P  GR+", "sequence_from_db": "PSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRA-RTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRV", "sequence_from_broadstreet": "MESTPKKAPRSKFPALLVVALALVALVFVIWRVDSAPSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRARTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRVISLKTSVGQFASAMRPIFTLIDTRHWYVIANFRETDLKNIRSGTPATIRLMSDSGKTFEGKVDSIGYGVLPDDGGLVLGGLPKVSRSINWVRVAQRFPVKIMVDKPDPEMFRIGASAVANLEPQ", "dna_sequence_from_broadstreet": "ATGGAAAGTACGCCGAAAAAAGCTCCTCGCAGTAAATTCCCTGCTCTGTTAGTGGTTGCGTTGGCGCTGGTTGCCCTTGTTTTCGTTATCTGGCGCGTAGACAGTGCGCCATCAACTAATGACGCTTACGCGTCAGCAGATACCATTGATGTGGTACCGGAAGTCAGCGGCCGCATTGTAGAACTGGCGGTCACCGACAACCAGGCAGTCAAACAGGGCGATTTGCTGTTCCGCATCGACCCGCGCCCGTACGAAGCCAATCTGGCGAAAGCTGAAGCCTCCCTCGCGGCGCTGGATAAGCAAATTATGCTCACCCAGCGTAGCGTTGACGCGCAACAGTTTGGTGCCGACTCGGTTAATGCCACGGTAGAAAAAGCCCGTGCCGCCGCGAAACAGGCCACAGATACATTACGCCGCACCGAGCCATTACTGAAAGAAGGTTTTGTCTCAGCGGAAGATGTTGACCGTGCAAGAACGGCGCAGCGCGCCGCAGAAGCGGATCTTAATGCCGTATTGTTACAGGCGCAGTCAGCCGCCAGCGCCGTCAGCGGCGTGGATGCATTAGTTGCCCAGCGTGCGGCGGTCGAAGCGGATATTGCCCTGACCAAACTGCATCTGGAAATGGCGACCGTTCGCGCGCCGTTTGATGGCCGGGTCATTTCCCTCAAAACCTCCGTCGGGCAATTTGCTTCTGCCATGCGCCCTATTTTTACCCTAATCGACACTCGTCACTGGTATGTGATCGCCAACTTCCGCGAAACCGATCTGAAAAATATTCGCTCAGGTACACCCGCAACGATTCGCCTGATGAGTGACAGCGGCAAAACCTTCGAGGGTAAAGTGGATTCGATTGGCTACGGCGTGCTACCGGATGACGGCGGCCTGGTGCTGGGCGGCCTGCCGAAAGTGTCTCGTTCTATTAACTGGGTCCGCGTTGCCCAGCGTTTTCCGGTCAAAATCATGGTCGATAAACCTGACCCGGAAATGTTCCGCATCGGCGCTTCGGCAGTCGCTAATCTTGAGCCGCAATAA", "partial": "0", "query_start": 86324, "query_end": 86707, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 27.17}, "gnl|BL_ORD_ID|2786|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "Klebsiella pneumoniae KpnG", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3298", "ARO_accession": "3004588", "ARO_name": "Klebsiella pneumoniae KpnG", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35957": {"category_aro_accession": "0000039", "category_aro_cvterm_id": "35957", "category_aro_name": "spectinomycin", "category_aro_description": "Spectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "36969": {"category_aro_accession": "3000625", "category_aro_cvterm_id": "36969", "category_aro_name": "polymyxin B1", "category_aro_description": "Polymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36970": {"category_aro_accession": "3000626", "category_aro_cvterm_id": "36970", "category_aro_name": "polymyxin B2", "category_aro_description": "Polymyxin B2 is in the family of polymyxin lipopeptides with a 6-methylheptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36971": {"category_aro_accession": "3000627", "category_aro_cvterm_id": "36971", "category_aro_name": "polymyxin B3", "category_aro_description": "Polymyxin B3 is in the family of polymyxin lipopeptides with an octanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36972": {"category_aro_accession": "3000628", "category_aro_cvterm_id": "36972", "category_aro_name": "polymyxin B4", "category_aro_description": "Polymyxin B4 is in the family of polymyxin lipopeptides with a heptanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.00289322, "max_identities": 43, "bit_score": 35.8094, "cvterm_id": "42597", "query": "IDPATYQASYDSAKGDLAKAQA---------AANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNA--------------AVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVD", "match": "I+    QA+ D  K  L++AQA         AAN+  +  +  Q    T   +Q + D A+   QQ NA              AV+ A   V  A + L  T++ SPISG + + +V  GA  Q G TT L  V     +++D", "sequence_from_db": "INSKQLQANIDVKKTALSQAQADLNRRIPLGAANL--IGREELQHARDTVASAQAELDVAI---QQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGA--QIGTTTPLMAVVPATNLWID", "sequence_from_broadstreet": "MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG", "dna_sequence_from_broadstreet": "ATGAGTGCAAATGCGGAGAGCCAAACCCCGCAGCAACCAGGCAGCAAAAAAGGAAAGCGTAAAGGCGCCCTTCTGTTGCTGACATTGCTCTTCATTATTATTGCCGTGGCATATGGGATTTACTGGTTTCTGGTACTGCGTCACTACGAAGAGACCGACGATGCCTACGTGGCAGGGAATCAGGTACAAATTATGGCTCAGGTCGCGGGCAGCGTGACCAAAGTCTGGGCTGACAACACGGACTACGTGCAGAAAGGCGATCCGCTGGTCACTCTCGATCGGACCGATGCCCAACAGGCGTTTGAAAAGGCTAAGACCCAACTGGCCGCCAGCGTCCGTCAGACCCGCCAGCAGATGATCAACAGCAAGCAGCTGCAGGCAAATATCGACGTCAAAAAAACCGCCCTCTCCCAGGCGCAGGCTGACCTGAACCGCCGCATCCCGCTGGGCGCCGCGAACCTCATTGGCCGCGAAGAGCTGCAGCACGCCCGCGATACCGTCGCCAGCGCACAGGCCGAACTCGACGTGGCAATCCAGCAGTACAACGCCAACCAGGCGATCGTGCTGGGCACCAGGCTGGAACAGCAGCCGGCGGTGCTCCAGGCGGCCACTGAAGTGCGTAACGCCTGGCTGGCCCTGCAGCGTACGCAGATCGTCAGCCCGATTAGCGGCTACGTTTCCCGTCGCTCGGTACAGCCTGGCGCGCAGATCGGCACCACCACGCCGCTGATGGCGGTGGTCCCGGCGACCAACCTGTGGATCGATGCTAACTTTAAAGAGACTCAGCTGGCGCATATGCGTATCGGCCAGCCGGCCACCGTGATCAGCGATATCTATGGCGATGACGTGAAATACACCGGTAAAGTGGTCGGTCTGGATATGGGTACCGGCAGCGCCTTCTCCCTGCTGCCGGCGCAGAATGCCACCGGCAACTGGATCAAAGTGGTACAGCGCCTGCCGGTTCGTATCGAGCTGGATGAAAAACAACTAGCGGAACACCCGCTGCGCATCGGCCTCTCGACGCTGGTGGAAGTCAACACCACCGATCGCGATGGTGAAATGCTGGCCAGCCAGGTGCGGAGCTCCCCGGTTTACGAGAGCAATGCCCGCGAAATCGCTCTCGATCCGGTTAATAAGCTGATAGACGAGATCATTCAGGCCAACGCCGGATAA", "partial": "0", "query_start": 86441, "query_end": 86800, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 30.07}, "gnl|BL_ORD_ID|1329|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "AAC(2')-Id", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "1415", "ARO_accession": "3002526", "ARO_name": "AAC(2')-Id", "ARO_category": {"36480": {"category_aro_accession": "3000341", "category_aro_cvterm_id": "36480", "category_aro_name": "AAC(2')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 2'.", "category_aro_class_name": "AMR Gene Family"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0226012, "max_identities": 18, "bit_score": 32.3426, "cvterm_id": "36769", "query": "NPDALLVPQQGVTRTPRGDASVMV--VGEGDKVEV---RQVTASQAIGDKW", "match": " P ++L P +G+ RTP  D S+ V  V   D +E+   R++T     GD W", "sequence_from_db": "GPTSVLTPTEGIVRTPEDDRSLFVLPVDLPDGLELDTAREITCDWRSGDPW", "sequence_from_broadstreet": "MLTQHVSEARTRGAIHTARLIHTSDLDQETRDGARRMVIEAFRDPSGDSDFTDDFTDDDWDHALGGMHALISHHGALIAHGAVVQRRLMYRGPDGRGHALRCGYVEAVAVREDRRGDGLGTAVLDALEQVIRGAYQIGALSASDIARPMYIARGWLSWEGPTSVLTPTEGIVRTPEDDRSLFVLPVDLPDGLELDTAREITCDWRSGDPW", "dna_sequence_from_broadstreet": "GTGCTCACCCAGCATGTCAGTGAGGCTCGCACGCGCGGTGCGATCCACACCGCGCGTCTGATCCACACCTCCGATCTGGACCAGGAAACCCGCGACGGCGCGCGCCGCATGGTGATCGAGGCGTTCCGCGATCCGTCCGGAGACAGTGATTTCACCGACGATTTCACCGACGACGACTGGGACCACGCGCTCGGCGGCATGCACGCGCTGATCTCTCACCACGGTGCGCTCATCGCGCACGGCGCCGTCGTCCAACGTCGGTTGATGTACCGGGGACCCGACGGTAGAGGTCACGCGCTGCGCTGCGGTTACGTCGAGGCCGTCGCGGTGCGCGAGGACCGGCGGGGCGACGGTCTGGGCACCGCCGTGCTCGACGCGCTCGAGCAGGTGATCCGCGGCGCCTATCAGATCGGCGCGCTGAGCGCGTCGGACATCGCCCGGCCGATGTACATTGCCAGGGGCTGGCTGTCGTGGGAGGGTCCGACATCGGTGCTGACCCCCACCGAGGGCATCGTTCGCACCCCTGAGGACGACCGGTCGCTGTTCGTCCTGCCGGTCGATCTCCCGGACGGCCTCGAGTTGGACACCGCGCGCGAGATCACGTGCGACTGGCGCTCCGGCGACCCCTGGTGA", "partial": "0", "query_start": 87059, "query_end": 87196, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 35.29}, "gnl|BL_ORD_ID|569|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "emrK", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "609", "ARO_accession": "3000206", "ARO_name": "emrK", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.538308, "max_identities": 42, "bit_score": 28.4906, "cvterm_id": "35914", "query": "VRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYI----SQQDYDTAVATAQQS---------------------NAAVVAAKA---------------------AVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQT", "match": "+  QVSG +   N  + + ++ G  L  +D      + + AK +LA      N   L  K+Y   + +  I    S +DY+  V  A+Q                      NAA+ A KA                     A + A + L  T + SP++G I + +V  G  V  GQ+", "sequence_from_db": "ISAQVSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKETLEHTKDTLISSKAALNAAIQAYKANKALVMNTPLNRQPQVVEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQS", "sequence_from_broadstreet": "MELEDMISTDDAYVTGNADPISAQVSGSVTVVNHKDTNYVRQGDILVSLDKTDATIALNKAKNNLANIVRQTNKLYLQDKQYSAEVASARIQYQQSLEDYNRRVPLAKQGVISKETLEHTKDTLISSKAALNAAIQAYKANKALVMNTPLNRQPQVVEAADATKEAWLALKRTDIKSPVTGYIAQRSVQVGETVSPGQSLMAVVPARQMWVNANFKETQLTDVRIGQSVNIISDLYGENVVFHGRVTGINMGTGNAFSLLPAQNATGNWIKIVQRVPVEVSLDPKELMEHPLRIGLSMTATIDTKNEDIAEMPELASTVTSMPAYTSKALVIDTSPIEKEISNIISHNGQL", "dna_sequence_from_broadstreet": "ATGGAATTAGAAGACATGATTAGTACAGATGACGCCTATGTCACGGGGAATGCAGATCCAATTTCTGCACAAGTCTCAGGTAGTGTCACTGTCGTTAATCATAAAGATACGAACTACGTTCGACAAGGTGACATTTTAGTTTCACTGGATAAAACTGATGCCACTATCGCACTCAATAAAGCTAAAAATAATCTGGCAAATATTGTTCGGCAAACGAATAAACTATACTTACAGGATAAACAATACAGTGCCGAAGTCGCTTCAGCACGTATTCAGTATCAACAATCTTTAGAAGATTATAACCGTCGAGTGCCGTTAGCGAAGCAGGGGGTTATTTCAAAAGAAACGCTGGAGCATACCAAAGATACGTTAATAAGTAGCAAAGCGGCATTGAATGCCGCTATCCAGGCTTATAAAGCGAATAAAGCTTTAGTAATGAACACACCATTAAACCGTCAGCCACAAGTCGTTGAAGCGGCGGATGCAACTAAAGAAGCCTGGTTGGCGCTTAAACGTACGGATATTAAGAGTCCGGTTACCGGCTATATTGCCCAGAGAAGTGTTCAGGTCGGCGAAACAGTGAGCCCCGGACAATCGTTAATGGCTGTCGTACCGGCACGTCAAATGTGGGTTAATGCCAACTTTAAAGAAACACAACTCACGGATGTACGGATTGGTCAATCGGTCAATATTATCAGCGATCTTTATGGTGAAAATGTTGTGTTTCATGGTCGGGTGACAGGGATCAATATGGGAACCGGCAATGCGTTCTCCTTATTACCTGCACAAAATGCGACAGGGAACTGGATCAAAATCGTTCAGCGTGTACCGGTTGAAGTTTCTCTTGATCCAAAAGAACTCATGGAACACCCCTTGCGTATTGGTTTATCGATGACAGCAACTATTGATACGAAGAACGAAGACATTGCCGAGATGCCTGAGCTGGCTTCAACCGTGACCTCCATGCCGGCTTATACCAGTAAGGCTTTAGTTATCGATACCAGTCCGATAGAAAAAGAAATTAGCAACATTATTTCGCATAATGGACAACTTTAA", "partial": "0", "query_start": 86357, "query_end": 86755, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 23.46}, "gnl|BL_ORD_ID|2461|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "LpeA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "680", "model_id": "2758", "ARO_accession": "3004099", "ARO_name": "LpeA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "36295": {"category_aro_accession": "3000156", "category_aro_cvterm_id": "36295", "category_aro_name": "spiramycin", "category_aro_description": "Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.86306, "max_identities": 52, "bit_score": 26.1794, "cvterm_id": "41208", "query": "DLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDP--IYVDVTQSSNDFLRLKQELADGRLKQENGKAKVE-LVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQV", "match": "+LAKAQ          +R   L+ + Y+S ++        ++   A + A+  +   RI L   +  +P  G IG     EGA V  G++     V   DP  + VD     ++   L +      L +    + ++ ++  D    P    ++  D  +  TT S+ L     N                     + +++P Q +    R     + + +  K+ +  V       DK  + +GLK+G +++  G +++ P + V", "sequence_from_db": "ELAKAQ---------YERITPLIKSGYVSTKE-------VEEKKQAWIDAQKELSKTRIELDNLRFYAPFDGIIGAYKKREGAQVNAGESV----VSIYDPSALVVDFDIPCSNLATLNEGQPVYVLGKRYSLSHLQKMLDEDTHMCPADVDIQCDDCLIGATT-SVELLVAEKN---------------------NTIVIPFQAIFL--RNSKPFVYLVKKGKIVLASVKTGLQQEDKIEIVEGLKAGQQLVTKGQERLYPEMTV", "sequence_from_broadstreet": "MLGIQFNRGQWRSNYYWQIPVLIIAVISILFFISKKLFYSKVTPESIPNKLVEVEPIKSHNLQQTIHLLGTIHPKHATTLIAKESGMLDTLIPTGQKVTKGTLIAKINNPDLEKNLQLSLSAVELAKAQYERITPLIKSGYVSTKEVEEKKQAWIDAQKELSKTRIELDNLRFYAPFDGIIGAYKKREGAQVNAGESVVSIYDPSALVVDFDIPCSNLATLNEGQPVYVLGKRYSLSHLQKMLDEDTHMCPADVDIQCDDCLIGATTSVELLVAEKNNTIVIPFQAIFLRNSKPFVYLVKKGKIVLASVKTGLQQEDKIEIVEGLKAGQQLVTKGQERLYPEMTVDIYHPATSSS", "dna_sequence_from_broadstreet": "GTGTTAGGAATTCAATTCAATAGAGGTCAATGGCGGTCAAACTATTATTGGCAAATACCTGTGCTGATAATAGCTGTTATTAGCATTCTGTTTTTCATCAGTAAAAAATTATTCTACTCAAAAGTTACGCCAGAAAGCATACCTAATAAACTGGTGGAAGTTGAGCCCATTAAAAGCCACAACTTACAACAAACAATCCATTTATTAGGTACCATTCATCCAAAACACGCAACGACATTAATTGCTAAAGAATCAGGTATGTTGGACACCCTTATCCCAACTGGTCAAAAAGTCACAAAAGGGACACTTATTGCAAAAATCAACAACCCTGATCTTGAAAAAAATCTACAGCTTTCATTAAGTGCGGTAGAATTGGCAAAAGCACAATATGAACGTATCACCCCTTTAATTAAATCAGGATATGTCAGTACAAAGGAAGTCGAAGAAAAAAAACAAGCCTGGATTGATGCCCAAAAAGAATTATCAAAAACAAGGATTGAATTAGATAACCTCCGCTTTTACGCTCCTTTCGACGGAATAATTGGAGCATACAAAAAGAGAGAAGGAGCACAAGTCAATGCAGGTGAATCTGTTGTAAGTATTTACGACCCTTCTGCTTTAGTTGTCGATTTTGATATTCCTTGCAGTAATTTGGCAACTCTTAATGAAGGTCAGCCGGTTTATGTGCTGGGTAAACGGTATTCATTAAGTCATTTACAAAAAATGCTCGACGAAGACACCCACATGTGCCCTGCTGATGTTGATATTCAATGTGATGATTGTCTTATTGGTGCGACCACAAGTGTTGAGCTCCTTGTTGCGGAAAAAAATAACACTATTGTCATCCCCTTCCAGGCAATATTTTTGAGAAATAGTAAACCTTTTGTATATCTTGTAAAAAAGGGAAAGATTGTGCTTGCTTCAGTGAAAACTGGGTTGCAACAAGAGGATAAAATTGAAATTGTCGAGGGATTAAAAGCTGGGCAACAACTGGTTACAAAAGGCCAGGAACGCTTATATCCTGAAATGACCGTTGATATTTATCATCCAGCGACAAGTAGCAGCTAA", "partial": "0", "query_start": 86486, "query_end": 87274, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 19.55}, "gnl|BL_ORD_ID|1114|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "tetQ", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1183", "ARO_accession": "3000191", "ARO_name": "tetQ", "ARO_category": {"35921": {"category_aro_accession": "0000002", "category_aro_cvterm_id": "35921", "category_aro_name": "tetracycline-resistant ribosomal protection protein", "category_aro_description": "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35986": {"category_aro_accession": "0000069", "category_aro_cvterm_id": "35986", "category_aro_name": "doxycycline", "category_aro_description": "Doxycycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome.", "category_aro_class_name": "Antibiotic"}, "36291": {"category_aro_accession": "3000152", "category_aro_cvterm_id": "36291", "category_aro_name": "minocycline", "category_aro_description": "Minocycline is second generation semi-synthetic derivative of the tetracycline group of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome and preventing the aminotransferase-tRNA from associating with the ribosome.", "category_aro_class_name": "Antibiotic"}, "36667": {"category_aro_accession": "3000528", "category_aro_cvterm_id": "36667", "category_aro_name": "chlortetracycline", "category_aro_description": "Chlortetracycline was an early, first-generation tetracycline antibiotic developed in the 1940's. It inhibits bacterial protein synthesis by binding to the 30S subunit of bacterial ribosomes, preventing the aminoacyl-tRNA from binding to the ribosome.", "category_aro_class_name": "Antibiotic"}, "37011": {"category_aro_accession": "3000667", "category_aro_cvterm_id": "37011", "category_aro_name": "demeclocycline", "category_aro_description": "Demeclocycline is a tetracycline analog with 7-chloro and 6-methyl groups. Due to its fast absorption and slow excretion, it maintains higher effective blood levels compared to other tetracyclines.", "category_aro_class_name": "Antibiotic"}, "37012": {"category_aro_accession": "3000668", "category_aro_cvterm_id": "37012", "category_aro_name": "oxytetracycline", "category_aro_description": "Oxytetracycline is a derivative of tetracycline with a 5-hydroxyl group. Its activity is similar to other tetracyclines.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.63946, "max_identities": 18, "bit_score": 25.409, "cvterm_id": "35916", "query": "NAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPI", "match": "NA++V     ++   INL    + + I    GK++VTE  L  +G T     V   D I", "sequence_from_db": "NASIVVYYCLIQMNIINLG---ILAHIDA--GKTSVTENLLFASGATEKCGRVDNGDTI", "sequence_from_broadstreet": "MRFDNASIVVYYCLIQMNIINLGILAHIDAGKTSVTENLLFASGATEKCGRVDNGDTITDSMDIEKRRGITVRASTTSIIWNGVKCNIIDTPGHMDFIAEVERTFKMLDGAVLILSAKEGIQAQTKLLFNTLQKLQIPTIIFINKIDRDGVNLERLYLDIKTNLSQDVLFMQTVVDGLVYPICSQTYIKEEYKEFVCNHDDNILERYLADSEISPADYWNTIIDLVAKAKVYPVLHGSAMFNIGINELLDAISSFILPPESVSNRLSAYLYKIEHDPKGHKRSFLKIIDGSLRLRDIVRINDSEKFIKIKNLKTIYQGREINVDEVGANDIAIVEDMEDFRIGDYLGTKPCLIQGLSHQHPALKSSVRPDRSEERSKVISALNTLWIEDPSLSFSINSYSDELEISLYGLTQKEIIQTLLEERFSVKVHFDEIKTIYKERPVKKVNKIIQIEVPPNPYWATIGLTLEPLPLGTGLQIESDISYGYLNHSFQNAVFEGIRMSCQSGLHGWEVTDLKVTFTQAEYYSPVSTPADFRQLTPYVFRLALQQSGVDILEPMLYFELQIPQAASSKAITDLQKMMSEIEDISCNNEWCHIKGKVPLNTSKDYASEVSSYTKGLGVFMVKPCGYQITKGDYSDNIRMNEKDKLLFMFQKSMSSK", "dna_sequence_from_broadstreet": "GTGCGTTTCGACAATGCATCTATTGTAGTATATTATTGCTTAATCCAAATGAATATTATAAATTTAGGAATTCTTGCTCACATTGATGCAGGAAAAACTTCCGTAACCGAGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTGCGGCCGTGTGGATAATGGTGACACCATAACAGACTCTATGGATATAGAGAAACGTAGAGGAATTACTGTTCGGGCTTCTACGACATCTATTATCTGGAATGGAGTGAAATGCAATATCATTGACACTCCGGGACACATGGATTTTATTGCGGAAGTGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCTCATCTTATCCGCAAAGGAAGGCATACAAGCGCAAACAAAGTTGCTGTTCAATACTTTACAAAAACTGCAAATCCCGACAATTATATTTATCAATAAAATTGACCGTGACGGTGTGAATTTAGAGCGTTTGTATCTGGATATAAAAACAAATCTGTCTCAAGATGTCCTGTTTATGCAAACTGTTGTCGATGGATTGGTTTATCCGATTTGCTCCCAAACATATATAAAGGAAGAATACAAAGAATTTGTATGCAACCATGACGACAATATATTAGAACGATATTTGGCGGATAGCGAAATTTCACCGGCTGATTATTGGAATACGATAATCGATCTTGTGGCAAAAGCCAAAGTCTATCCGGTACTACATGGATCAGCAATGTTCAATATCGGTATCAATGAGTTGTTGGACGCCATCTCTTCTTTTATACTTCCTCCAGAATCAGTCTCAAACAGACTTTCAGCTTATCTCTATAAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTTTTCTAAAAATAATTGACGGAAGTCTGAGACTTCGAGACATTGTAAGAATCAACGATTCGGAAAAATTCATCAAGATTAAAAATCTAAAGACTATTTATCAGGGCAGAGAGATAAATGTTGATGAAGTGGGGGCCAATGATATCGCGATTGTAGAAGATATGGAAGATTTTCGAATCGGAGATTATTTAGGTACTAAACCTTGTTTGATTCAAGGGTTATCTCATCAGCATCCCGCTCTCAAATCCTCCGTCCGGCCAGACAGGTCCGAAGAGAGAAGCAAGGTGATATCCGCTCTGAATACATTGTGGATTGAAGACCCGTCTTTGTCCTTTTCCATAAACTCATATAGTGATGAATTGGAAATCTCGTTATATGGTTTGACACAAAAGGAAATCATACAGACATTGCTGGAAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGATCAAGACTATCTACAAAGAACGACCTGTAAAAAAGGTCAATAAGATTATTCAGATCGAAGTGCCACCCAACCCTTACTGGGCCACAATAGGGCTGACGCTTGAACCCTTGCCGTTAGGGACAGGGTTGCAAATCGAAAGTGACATCTCCTATGGTTATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGGGATTCGTATGTCTTGCCAATCTGGTTTACATGGATGGGAAGTGACTGATCTGAAAGTAACTTTTACTCAAGCCGAGTATTATAGCCCGGTAAGTACACCTGCTGATTTCAGACAGCTGACCCCTTATGTCTTCAGGCTGGCCTTGCAACAGTCAGGTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTTGCAGATACCCCAAGCGGCAAGTTCCAAAGCTATTACAGATTTGCAAAAAATGATGTCTGAGATTGAAGACATCAGTTGCAATAATGAGTGGTGTCATATTAAAGGGAAAGTTCCATTAAATACAAGTAAAGACTACGCCTCAGAAGTAAGTTCATACACTAAGGGCTTAGGCGTTTTTATGGTCAAGCCATGCGGGTATCAAATAACAAAAGGCGATTATTCTGATAATATCCGCATGAACGAAAAAGATAAACTTTTATTCATGTTCCAAAAATCAATGTCATCAAAATAA", "partial": "0", "query_start": 86615, "query_end": 86791, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 30.51}, "gnl|BL_ORD_ID|1072|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 86156, "orf_end": 87349, "orf_from": "NODE_6_length_262587_cov_42.4347_106 ", "model_name": "TEM-90", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "1137", "ARO_accession": "3000957", "ARO_name": "TEM-90", "ARO_category": {"36023": {"category_aro_accession": "3000014", "category_aro_cvterm_id": "36023", "category_aro_name": "TEM beta-lactamase", "category_aro_description": "TEM-1 is the most commonly-encountered beta-lactamase in gram-negative bacteria. Up to 90% of ampicillin resistance in E. coli is due to the production of TEM-1. Also responsible for the ampicillin and penicillin resistance that is seen in H. influenzae and N. gonorrhoeae in increasing numbers. Although TEM-type beta-lactamases are most often found in E. coli and K. pneumoniae, they are also found in other species of gram-negative bacteria with increasing frequency. The amino acid substitutions responsible for the ESBL phenotype cluster around the active site of the enzyme and change its configuration, allowing access to oxyimino-beta-lactam substrates. Opening the active site to beta-lactam substrates also typically enhances the susceptibility of the enzyme to b-lactamase inhibitors, such as clavulanic acid.  Although the inhibitor-resistant beta-lactamases are not ESBLs, they are often discussed with ESBLs because they are also derivatives of the classical TEM- or SHV-type enzymes. These enzymes were at first given the designation IRT for inhibitor-resistant TEM beta-lactamase; however, all have subsequently been renamed with numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM beta-lactamases. Inhibitor-resistant TEM beta-lactamases have been found mainly in clinical isolates of E. coli, but also some strains of K. pneumoniae, Klebsiella oxytoca, P. mirabilis, and Citrobacter freundii. Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam-lactamase inhibitor combinations of amoxicillin-clavulanate (Co-amoxiclav), ticarcillin-clavulanate, and ampicillin/sulbactam, they normally remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin/tazobactam, although resistance has been described.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.73227, "max_identities": 10, "bit_score": 24.6386, "cvterm_id": "35914", "query": "LKYPQSGTLEFSDVTVDQTTGSITLRAI", "match": "+ Y Q+  +E+S VT    TG +T+R +", "sequence_from_db": "IHYSQNDLVEYSPVTEKHLTGGMTVREL", "sequence_from_broadstreet": "MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTGGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW", "dna_sequence_from_broadstreet": "ATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGGTGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGCAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAA", "partial": "0", "query_start": 86909, "query_end": 86992, "orf_dna_sequence": "ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCTCAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACCAGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGCGTCTCCCTGTATCAGATCGATCCAGCCACCTATCAGGCCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAACATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCAAATATATTAGTCAACAAGACTACGATACCGCCGTTGCGACGGCGCAGCAGAGCAATGCGGCCGTGGTCGCGGCGAAAGCGGCCGTTGAAACCGCGCGCATCAATCTGGCCTACACCAAAGTCACCTCGCCGATCAGCGGCCGGATTGGTAAATCCACCGTGACCGAAGGGGCGCTGGTACAGAATGGTCAAACGACCGCCCTGGCAACCGTTCAGCAGCTGGATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGGCCGCCTGAAACAGGAAAACGGCAAAGCGAAAGTGGAGCTAGTGACTAATGACGGTCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAGACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTACCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAAGGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGGGAAGGCGATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTTATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAACGCGCCATCAGAACAAACCAAGTCTTAA", "orf_prot_sequence": "MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAGVSLYQIDPATYQASYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTKYISQQDYDTAVATAQQSNAAVVAAKAAVETARINLAYTKVTSPISGRIGKSTVTEGALVQNGQTTALATVQQLDPIYVDVTQSSNDFLRLKQELADGRLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRVIVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS", "perc_identity": 35.71}}, "NODE_6_length_262587_cov_42.4347_107 # 87372 # 90518 # 1 # ID=6_107;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.569": {"gnl|BL_ORD_ID|1035|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 87372, "orf_end": 90518, "orf_from": "NODE_6_length_262587_cov_42.4347_107", "model_name": "acrB", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1104", "pass_evalue": "n/a", "pass_bitscore": "1900", "ARO_accession": "3000216", "ARO_name": "acrB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1941.39, "max_identities": 960, "cvterm_id": "36849", "query": "MPNFFIDRPIFAWVIAIIIMLAGGLSILKLPVAQYPTIAPPAISITAMYPGADAETVQNTVTQVIEQNMNGIDHLMYMSSNGDSTGTATITLTFESGTDPDIAQVQVQNKLALATPLLPQEVQQQGISVEKASSSFLMVVGVINTNGTMNQDDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVISALKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTNTEEFGNILLKVNQDGSQVRLRDVAKIELGGESYDVVAKFNGQPASGLGIKLATGANALDTANAIRAELAKMEPFFPSGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIQKGSHG-ATTGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAWLFVRLPSSFLPDEDQGVFLSMAQLPAGATQERTQKVLDEMTNYYLTKEKDNVESVFAVNGFGFAGRGQNTGIAFVSLKDWSQRPGEENKVEAITARAMGYFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQGGLGHEKLTQARNQLFGMVAQHPDVLTGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYIMSEAKYRMLPEDIGKWYVRGSDGQMVPFSAFSTSRWEYGSPRLERYNGLPSLEILGQAAPGKSTGEAMALMEELAGKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVVGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATILAIFFVPVFFVVVRRRFSKKSEDIEHSHQVEHH", "match": "MPNFFIDRPIFAWVIAIIIMLAGGL+ILKLPVAQYPTIAPPA++I+A YPGADA+TVQ+TVTQVIEQNMNGID+LMYMSSN DSTGT  ITLTFESGTD DIAQVQVQNKL LA PLLPQEVQQQG+SVEK+SSSFLMVVGVINT+GTM Q+DISDYVAANMKD ISRTSGVGDVQLFGSQYAMRIWM+PN+LN FQLTPVDVI+A+KAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLT+TEEFG ILLKVNQDGS+V LRDVAKIELGGE+YD++A+FNGQPASGLGIKLATGANALDTA AIRAELAKMEPFFPSG+KIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVF+PMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPI KG HG    GFFGWFNRMF+KSTHHYTDSVG ILRSTGRYLVLYLIIVVGMA+LFVRLPSSFLPDEDQGVF++M QLPAGATQERTQKVL+E+T+YYLTKEK+NVESVFAVNGFGFAGRGQNTGIAFVSLKDW+ RPGEENKVEAIT RA   FSQIKDAMVFAFNLPAIVELGTATGFDFELIDQ GLGHEKLTQARNQL    A+HPD+LT VRPNGLEDTPQFKIDIDQEKAQALGVSI+DINTTLGAAWGGSYVNDFIDRGRVKKVY+MSEAKYRMLP+DIG WYVR +DGQMVPFSAFS+SRWEYGSPRLERYNGLPS+EILGQAAPGKSTGEAM LME+LA KLP+G+GYDWTGMSYQERLSGNQAP+LYAISLIVVFLCLAALYESWSIPFSVMLVVPLGV+GALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLM+KEGKGLIEATL+AVRMRLRPILMTSLAFILGVMPLVIS+GAGSGAQNAVGTGVMGGMVTAT+LAIFFVPVFFVVVRRRFS+K+EDIEHSH V+HH", "sequence_from_db": "MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH", "sequence_from_broadstreet": "MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH", "dna_sequence_from_broadstreet": "ATGCCTAATTTCTTTATCGATCGCCCGATTTTTGCGTGGGTGATCGCCATTATCATCATGTTGGCAGGGGGGCTGGCGATCCTCAAACTGCCGGTGGCGCAATATCCTACGATTGCACCGCCGGCAGTAACGATCTCCGCCTCCTACCCCGGCGCTGATGCGAAAACAGTGCAGGACACGGTGACACAGGTTATCGAACAGAATATGAACGGTATCGATAACCTGATGTACATGTCCTCTAACAGTGACTCCACGGGTACCGTGCAGATCACCCTGACCTTTGAGTCTGGTACTGATGCGGATATCGCGCAGGTTCAGGTGCAGAACAAACTGCAGCTGGCGATGCCGTTGCTGCCGCAAGAAGTTCAGCAGCAAGGGGTGAGCGTTGAGAAATCATCCAGCAGCTTCCTGATGGTTGTCGGCGTTATCAACACCGATGGCACCATGACGCAGGAGGATATCTCCGACTACGTGGCGGCGAATATGAAAGATGCCATCAGCCGTACGTCGGGCGTGGGTGATGTTCAGTTGTTCGGTTCACAGTACGCGATGCGTATCTGGATGAACCCGAATGAGCTGAACAAATTCCAGCTAACGCCGGTTGATGTCATTACCGCCATCAAAGCGCAGAACGCCCAGGTTGCGGCGGGTCAGCTCGGTGGTACGCCGCCGGTGAAAGGCCAACAGCTTAACGCCTCTATTATTGCTCAGACGCGTCTGACCTCTACTGAAGAGTTCGGCAAAATCCTGCTGAAAGTGAATCAGGATGGTTCCCGCGTGCTGCTGCGTGACGTCGCGAAGATTGAGCTGGGTGGTGAGAACTACGACATCATCGCAGAGTTTAACGGCCAACCGGCTTCCGGTCTGGGGATCAAGCTGGCGACCGGTGCAAACGCGCTGGATACCGCTGCGGCAATCCGTGCTGAACTGGCGAAGATGGAACCGTTCTTCCCGTCGGGTCTGAAAATTGTTTACCCATACGACACCACGCCGTTCGTGAAAATCTCTATTCACGAAGTGGTTAAAACGCTGGTCGAAGCGATCATCCTCGTGTTCCTGGTTATGTATCTGTTCCTGCAGAACTTCCGCGCGACGTTGATTCCGACCATTGCCGTACCGGTGGTATTGCTCGGGACCTTTGCCGTCCTTGCCGCCTTTGGCTTCTCGATAAACACGCTAACAATGTTCGGGATGGTGCTCGCCATCGGCCTGTTGGTGGATGACGCCATCGTTGTGGTAGAAAACGTTGAGCGTGTTATGGCGGAAGAAGGTTTGCCGCCAAAAGAAGCTACCCGTAAGTCGATGGGGCAGATTCAGGGCGCTCTGGTCGGTATCGCGATGGTACTGTCGGCGGTATTCGTACCGATGGCCTTCTTTGGCGGTTCTACTGGTGCTATCTATCGTCAGTTCTCTATTACCATTGTTTCAGCAATGGCGCTGTCGGTACTGGTGGCGTTGATCCTGACTCCAGCTCTTTGTGCCACCATGCTGAAACCGATTGCCAAAGGCGATCACGGGGAAGGTAAAAAAGGCTTCTTCGGCTGGTTTAACCGCATGTTCGAGAAGAGCACGCACCACTACACCGACAGCGTAGGCGGTATTCTGCGCAGTACGGGGCGTTACCTGGTGCTGTATCTGATCATCGTGGTCGGCATGGCCTATCTGTTCGTGCGTCTGCCAAGCTCCTTCTTGCCAGATGAGGACCAGGGCGTGTTTATGACCATGGTTCAGCTGCCAGCAGGTGCAACGCAGGAACGTACACAGAAAGTGCTCAATGAGGTAACGCATTACTATCTGACCAAAGAAAAGAACAACGTTGAGTCGGTGTTCGCCGTTAACGGCTTCGGCTTTGCGGGACGTGGTCAGAATACCGGTATTGCGTTCGTTTCCTTGAAGGACTGGGCCGATCGTCCGGGCGAAGAAAACAAAGTTGAAGCGATTACCATGCGTGCAACACGCGCTTTCTCGCAAATCAAAGATGCGATGGTTTTCGCCTTTAACCTGCCCGCAATCGTGGAACTGGGTACTGCAACCGGCTTTGACTTTGAGCTGATTGACCAGGCTGGCCTTGGTCACGAAAAACTGACTCAGGCGCGTAACCAGTTGCTTGCAGAAGCAGCGAAGCACCCTGATATGTTGACCAGCGTACGTCCAAACGGTCTGGAAGATACCCCGCAGTTTAAGATTGATATCGACCAGGAAAAAGCGCAGGCGCTGGGTGTTTCTATCAACGACATTAACACCACTCTGGGCGCTGCATGGGGCGGCAGCTATGTGAACGACTTTATCGACCGCGGTCGTGTGAAGAAAGTTTATGTCATGTCAGAAGCGAAATACCGTATGCTGCCGGATGATATCGGCGACTGGTATGTTCGTGCTGCTGATGGTCAGATGGTGCCATTCTCGGCGTTCTCCTCTTCTCGTTGGGAGTACGGTTCGCCGCGTCTGGAACGTTACAACGGCCTGCCATCCATGGAAATCTTAGGCCAGGCGGCACCGGGTAAAAGTACCGGTGAAGCAATGGAGCTGATGGAACAACTGGCGAGCAAACTGCCTACCGGTGTTGGCTATGACTGGACGGGGATGTCCTATCAGGAACGTCTCTCCGGCAACCAGGCACCTTCACTGTACGCGATTTCGTTGATTGTCGTGTTCCTGTGTCTGGCGGCGCTGTACGAGAGCTGGTCGATTCCGTTCTCCGTTATGCTGGTCGTTCCGCTGGGGGTTATCGGTGCGTTGCTGGCTGCCACCTTCCGTGGCCTGACCAATGACGTTTACTTCCAGGTAGGCCTGCTCACAACCATTGGGTTGTCGGCGAAGAACGCGATCCTTATCGTCGAATTCGCCAAAGACTTGATGGATAAAGAAGGTAAAGGTCTGATTGAAGCGACGCTTGATGCGGTGCGGATGCGTTTACGTCCGATCCTGATGACCTCGCTGGCGTTTATCCTCGGCGTTATGCCGCTGGTTATCAGTACTGGTGCTGGTTCCGGCGCGCAGAACGCAGTAGGTACCGGTGTAATGGGCGGGATGGTGACCGCAACGGTACTGGCAATCTTCTTCGTTCCGGTATTCTTTGTGGTGGTTCGCCGCCGCTTTAGCCGCAAGAATGAAGATATCGAGCACAGCCATACTGTCGATCATCATTGA", "partial": "0", "query_start": 87372, "query_end": 90515, "orf_dna_sequence": "ATGCCTAATTTCTTTATCGATCGCCCCATATTTGCATGGGTGATCGCCATTATCATCATGCTGGCTGGGGGATTATCGATCCTCAAATTGCCGGTGGCGCAATATCCGACGATTGCGCCGCCAGCAATTTCCATTACCGCCATGTACCCCGGTGCTGACGCCGAAACGGTGCAGAACACCGTAACTCAGGTTATCGAACAGAATATGAACGGTATCGATCACCTGATGTACATGTCCTCAAATGGCGACTCCACCGGTACGGCAACCATTACGCTGACCTTCGAATCCGGTACCGATCCGGATATCGCCCAGGTTCAGGTTCAGAACAAGCTGGCGCTGGCGACGCCTCTGCTGCCGCAAGAAGTACAGCAGCAAGGGATTAGCGTTGAGAAAGCGTCCAGCAGCTTCCTGATGGTTGTCGGCGTCATTAACACCAACGGCACCATGAACCAGGACGATATTTCGGACTACGTGGCGGCCAACATGAAGGATCCGATTAGCCGTACCAGCGGCGTCGGCGACGTTCAGCTATTCGGTTCCCAGTATGCGATGCGTATCTGGATGGATCCAAACAAACTGAACAACTTCCAGCTTACGCCGGTGGATGTGATCAGCGCCCTGAAAGCGCAGAACGCCCAGGTGGCCGCGGGCCAGTTAGGCGGTACGCCGCCGGTGAAAGGCCAGCAGCTTAACGCCTCGATCATCGCGCAGACGCGTCTGACCAATACGGAAGAGTTTGGCAACATCCTGCTGAAGGTGAACCAGGACGGTTCCCAGGTTCGTCTGCGTGATGTCGCCAAAATTGAGCTGGGCGGCGAAAGCTATGACGTAGTGGCGAAGTTTAACGGCCAGCCGGCATCCGGTCTGGGTATTAAACTGGCTACCGGCGCGAACGCGCTGGATACCGCCAACGCTATTCGCGCTGAACTGGCGAAGATGGAGCCGTTTTTCCCGTCGGGGATGAAGATCGTTTACCCGTATGACACCACCCCGTTCGTGAAAATTTCTATTCACGAAGTGGTTAAAACGCTGGTGGAAGCGATCATCCTGGTGTTCCTGGTCATGTATCTGTTCCTGCAGAACTTCCGCGCCACCCTGATCCCCACCATCGCGGTACCGGTGGTCCTGTTAGGCACCTTCGCGGTGCTGGCGGCGTTTGGCTTCTCGATAAACACCCTGACGATGTTCGGGATGGTGCTCGCCATCGGCCTGTTGGTGGATGACGCCATCGTGGTGGTAGAGAACGTCGAGCGCGTGATGGCGGAAGAGGGTCTGCCGCCGAAAGAAGCGACGCGTAAATCGATGGGACAGATTCAGGGCGCGCTGGTTGGTATCGCTATGGTGCTGTCGGCGGTATTTATCCCGATGGCGTTCTTCGGCGGCTCAACCGGGGCCATCTATCGCCAGTTCTCCATCACTATCGTTTCCGCGATGGCGCTGTCGGTACTGGTGGCGTTAATCCTGACGCCGGCGCTGTGCGCCACGATGCTGAAACCCATTCAGAAAGGCAGCCATGGCGCGACCACCGGCTTCTTCGGCTGGTTTAACCGCATGTTTGATAAGAGCACGCACCATTACACCGACAGCGTAGGCAACATTCTGCGCAGCACCGGTCGTTATCTGGTGCTGTATCTGATCATCGTGGTGGGTATGGCATGGCTGTTCGTCCGTCTGCCGAGCTCGTTCCTGCCGGACGAGGACCAGGGTGTATTCCTGAGTATGGCGCAGCTGCCTGCCGGCGCCACCCAGGAGCGTACGCAGAAAGTGCTGGATGAGATGACGAATTACTATCTCACCAAAGAGAAGGACAACGTGGAATCCGTGTTTGCGGTTAACGGCTTCGGTTTCGCCGGCCGCGGCCAGAACACCGGTATCGCGTTCGTTTCGCTGAAAGACTGGAGCCAGCGTCCGGGTGAGGAAAACAAAGTTGAAGCGATCACCGCGAGAGCAATGGGCTACTTCTCGCAGATTAAAGATGCGATGGTCTTCGCCTTTAACCTGCCGGCTATCGTTGAACTGGGTACCGCGACCGGCTTTGACTTCGAGCTGATTGACCAGGGCGGTCTGGGCCACGAAAAACTGACCCAGGCGCGTAACCAACTGTTTGGCATGGTGGCGCAGCATCCTGACGTGCTGACCGGCGTGCGCCCTAACGGTCTGGAAGATACACCGCAGTTTAAAATCGATATCGATCAGGAGAAAGCTCAGGCGCTGGGCGTCTCCATCAGCGACATTAACACCACGCTGGGCGCAGCCTGGGGCGGAAGCTATGTCAACGACTTTATCGACCGCGGCCGCGTGAAGAAAGTGTACATCATGTCCGAAGCGAAATACCGTATGCTGCCGGAAGATATCGGCAAGTGGTATGTTCGCGGCAGCGATGGTCAGATGGTGCCGTTCTCTGCTTTCTCGACCTCGCGTTGGGAATACGGTTCGCCGCGTCTGGAACGCTACAACGGTCTGCCGTCACTGGAAATCCTCGGTCAGGCCGCGCCAGGCAAGAGTACCGGTGAGGCGATGGCGCTGATGGAAGAGCTGGCGGGTAAACTGCCTTCCGGTATCGGCTACGACTGGACCGGGATGTCTTATCAGGAGCGACTGTCCGGCAACCAGGCCCCTGCCCTGTATGCCATCTCGCTGATTGTCGTCTTCCTGTGTCTGGCGGCGCTGTATGAGAGCTGGTCGATTCCGTTCTCGGTTATGCTGGTCGTCCCCTTGGGTGTGGTTGGTGCGCTGTTAGCCGCCACCTTCCGCGGGCTAACCAACGACGTTTACTTCCAGGTGGGTCTGCTGACCACCATCGGCCTGTCGGCGAAGAACGCAATATTGATCGTTGAATTCGCCAAAGACCTGATGGAGAAAGAGGGCAAAGGGCTGATTGAGGCGACGCTTGAAGCAGTACGTATGCGTCTACGTCCAATCCTGATGACATCTCTGGCGTTCATCCTCGGGGTAATGCCGCTAGTTATCAGCTCCGGCGCCGGCTCCGGTGCGCAGAACGCCGTCGGTACAGGCGTAATGGGCGGGATGGTGACCGCGACGATCCTGGCGATCTTCTTCGTGCCGGTGTTCTTTGTGGTGGTTCGTCGCCGCTTTAGCAAAAAATCGGAAGATATAGAGCACAGCCATCAGGTTGAGCATCATTAA", "orf_prot_sequence": "MPNFFIDRPIFAWVIAIIIMLAGGLSILKLPVAQYPTIAPPAISITAMYPGADAETVQNTVTQVIEQNMNGIDHLMYMSSNGDSTGTATITLTFESGTDPDIAQVQVQNKLALATPLLPQEVQQQGISVEKASSSFLMVVGVINTNGTMNQDDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTPVDVISALKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTNTEEFGNILLKVNQDGSQVRLRDVAKIELGGESYDVVAKFNGQPASGLGIKLATGANALDTANAIRAELAKMEPFFPSGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIQKGSHGATTGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAWLFVRLPSSFLPDEDQGVFLSMAQLPAGATQERTQKVLDEMTNYYLTKEKDNVESVFAVNGFGFAGRGQNTGIAFVSLKDWSQRPGEENKVEAITARAMGYFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQGGLGHEKLTQARNQLFGMVAQHPDVLTGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYIMSEAKYRMLPEDIGKWYVRGSDGQMVPFSAFSTSRWEYGSPRLERYNGLPSLEILGQAAPGKSTGEAMALMEELAGKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVVGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATILAIFFVPVFFVVVRRRFSKKSEDIEHSHQVEHH", "perc_identity": 91.52}}, "NODE_6_length_262587_cov_42.4347_234 # 216120 # 217280 # 1 # ID=6_234;partial=00;start_type=TTG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.621": {"gnl|BL_ORD_ID|2080|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 216120, "orf_end": 217280, "orf_from": "NODE_6_length_262587_cov_42.4347_234", "model_name": "Escherichia coli ampH", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3307", "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3004612", "ARO_name": "Escherichia coli ampH beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 690.263, "max_identities": 330, "cvterm_id": "42578", "query": "MKRSLLIFAALCAASWTSVQAAQPTVDPVFASDVVDRYANHIYYGSGATGMALVVIDGNQRVFRSFGETRPGNNQHPQLDSVIRIASLSKLMTSEMLVKLLDQGVVKLNDPLSKYAPPGARVPDWQGKPITLVNLATHTSALPREQPGGAAHRPVFVWPTRQQRWNWLSTATLKAAPGSQAAYSNLAFDLLADALATAAGKPYPQLFEEQITRPLGMKDTTFTPSPDQCQRLMIPEKGASPCNNTLAAIGSGGVYSTPGDMMRWMQQFLSSDFYTRSQQADRMQTLIYQRNQLTRVIGMDVPGRADALGLGWVYMKPKNGHPGIIQKTGGGGGFITYMAMNPQANVGAFVVVTRSPLTRFNNMSDGINDLVSELSGAQPNMQTAS", "match": "MKRSLL  A LCAAS TSV AAQP  +P FASD+VDRYA+HI+YGSGATGMALVVIDGNQRVFRS+GETRPGNN  PQLDSV+RIASL+KLMTSEMLVKLLDQG VKLNDPLSKYAPPGARVP + G PITLVNLATHTSALPREQPGGAAHRPVFVWPTR+QRW +LSTA LKAAPGSQAAYSNLAFDLLADALA A+GKPY QLFEEQITRPLGMKDTT+TPSPDQC+RLM+ E+GASPCNNTLAAIGSGGVYSTPGDMMRWMQQ+LSSDFY RS QADRMQTLIYQR Q T+VIGMDVPG+ADALGLGWVYM PK G PGIIQKTGGGGGFITYMAM PQ N+GAFVVVTRSPLTRF NMSDGINDLV+ELSG +P +  AS", "sequence_from_db": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS", "sequence_from_broadstreet": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS", "dna_sequence_from_broadstreet": "TTGAAACGTAGTCTGCTTTTTTCTGCCGTGCTGTGTGCGGCGTCATTGACCTCCGTCCATGCGGCGCAGCCGATCACTGAACCGGAGTTTGCCTCTGATATTGTCGATCGTTATGCCGATCATATTTTTTACGGCAGCGGTGCCACGGGGATGGCTCTGGTTGTTATCGACGGTAACCAGCGCGTCTTTCGCAGTTATGGCGAAACGCGACCTGGTAATAACGTTCGCCCGCAGCTGGATTCGGTCGTGCGTATTGCTTCCCTCACCAAGCTAATGACCAGTGAGATGCTGGTGAAATTGCTCGACCAGGGGACCGTGAAGTTAAACGATCCGCTAAGTAAATATGCTCCGCCAGGCGCACGCGTGCCAACCTACAATGGGACGCCCATTACGCTGGTCAATCTGGCAACCCATACCAGCGCCCTGCCCCGTGAACAGCCCGGTGGCGCGGCACATCGTCCGGTGTTTGTCTGGCCAACGCGCGAGCAACGCTGGAAATACCTTTCTACGGCGAAGCTGAAAGCCGCGCCAGGCAGTCAGGCGGCGTACTCTAACCTTGCGTTCGACCTGCTGGCAGATGCACTGGCGAATGCGTCCGGCAAGCCTTATACCCAGTTGTTTGAAGAGCAGATTACCCGTCCATTGGGGATGAAAGACACCACCTACACCCCCTCACCGGATCAGTGCCGCCGTTTAATGGTTGCTGAGCGCGGTGCCAGTCCGTGCAATAACACGCTGGCGGCAATTGGCAGCGGCGGCGTCTATTCCACGCCTGGCGATATGATGCGCTGGATGCAGCAGTATTTGTCATCTGATTTTTATCAGCGCAGTAACCAGGCAGATCGCATGCAGACGTTGATTTATCAGCGCGCGCAGTTTACGAAAGTGATTGGCATGGATGTCCCCGGCAAAGCGGATGCGCTTGGTTTAGGTTGGGTATATATGGCCCCGAAAGAGGGTCGTCCGGGGATTATTCAGAAGACAGGCGGTGGTGGCGGTTTCATTACCTATATGGCGATGATCCCGCAGAAGAATATTGGCGCGTTTGTGGTGGTCACTCGTTCGCCGTTGACGCGCTTTAAAAATATGAGCGATGGCATCAATGACCTGGTGACCGAGCTAAGCGGGAATAAACCGTTGGTTATCCCCGCGTCCTGA", "partial": "0", "query_start": 216120, "query_end": 217274, "orf_dna_sequence": "TTGAAACGTAGTTTGCTCATTTTTGCTGCGCTGTGCGCGGCGTCGTGGACCTCGGTGCAGGCCGCACAGCCTACCGTTGACCCGGTTTTCGCCTCGGATGTGGTCGATCGTTACGCCAATCATATCTACTACGGCAGCGGCGCCACCGGCATGGCGCTGGTGGTTATCGATGGCAATCAGCGTGTTTTTCGCAGCTTTGGCGAAACCCGCCCGGGGAATAATCAGCACCCGCAGCTCGACTCGGTGATCCGTATCGCCTCCCTCAGCAAACTGATGACCAGCGAGATGCTGGTGAAGCTGCTCGACCAGGGGGTGGTGAAACTCAACGATCCGCTGAGTAAATACGCCCCGCCGGGCGCCCGGGTGCCTGACTGGCAGGGAAAACCAATCACCCTGGTGAATCTCGCGACCCATACCAGCGCCCTGCCGCGCGAGCAGCCTGGTGGCGCCGCTCATCGTCCGGTGTTTGTCTGGCCGACCCGCCAGCAGCGCTGGAACTGGCTCTCTACCGCGACCCTGAAAGCCGCGCCGGGCTCGCAGGCGGCCTACTCCAACCTGGCCTTCGATTTACTGGCAGACGCGCTCGCCACCGCCGCCGGCAAACCGTATCCGCAGCTGTTTGAAGAGCAGATCACCCGGCCGCTGGGGATGAAGGACACCACCTTTACCCCGTCACCGGATCAGTGCCAGCGGCTGATGATCCCGGAAAAAGGCGCCAGCCCATGCAACAACACCCTGGCGGCGATCGGCAGCGGCGGAGTCTACTCGACGCCGGGGGATATGATGCGCTGGATGCAGCAGTTCCTGTCATCCGATTTCTATACCCGCAGCCAGCAGGCCGACCGGATGCAGACGCTGATTTATCAGCGTAACCAGCTGACCCGGGTGATTGGTATGGACGTGCCGGGCCGCGCCGACGCGCTGGGCCTCGGCTGGGTGTATATGAAGCCGAAGAACGGCCATCCGGGGATTATTCAGAAAACCGGCGGCGGCGGCGGGTTTATCACCTATATGGCGATGAATCCGCAGGCTAACGTTGGCGCCTTTGTGGTGGTAACCCGCTCGCCGTTGACCCGCTTCAACAATATGAGCGATGGCATCAACGACCTGGTCAGCGAGCTGAGCGGCGCACAGCCCAACATGCAGACGGCCAGCCAGTAA", "orf_prot_sequence": "MKRSLLIFAALCAASWTSVQAAQPTVDPVFASDVVDRYANHIYYGSGATGMALVVIDGNQRVFRSFGETRPGNNQHPQLDSVIRIASLSKLMTSEMLVKLLDQGVVKLNDPLSKYAPPGARVPDWQGKPITLVNLATHTSALPREQPGGAAHRPVFVWPTRQQRWNWLSTATLKAAPGSQAAYSNLAFDLLADALATAAGKPYPQLFEEQITRPLGMKDTTFTPSPDQCQRLMIPEKGASPCNNTLAAIGSGGVYSTPGDMMRWMQQFLSSDFYTRSQQADRMQTLIYQRNQLTRVIGMDVPGRADALGLGWVYMKPKNGHPGIIQKTGGGGGFITYMAMNPQANVGAFVVVTRSPLTRFNNMSDGINDLVSELSGAQPNMQTASQ", "perc_identity": 85.71}}, "NODE_8_length_247415_cov_40.5207_219 # 227800 # 229548 # -1 # ID=8_219;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.567": {"gnl|BL_ORD_ID|2249|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 227800, "orf_end": 229548, "orf_from": "NODE_8_length_247415_cov_40.5207_219", "model_name": "msbA", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2423", "pass_evalue": "n/a", "pass_bitscore": "1000", "ARO_accession": "3003950", "ARO_name": "msbA", "ARO_category": {"36002": {"category_aro_accession": "0010001", "category_aro_cvterm_id": "36002", "category_aro_name": "ATP-binding cassette (ABC) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. ATP-binding cassette (ABC) transporters are present in all cells of all organisms and use the energy of ATP binding/hydrolysis to transport substrates across cell membranes.", "category_aro_class_name": "AMR Gene Family"}, "37033": {"category_aro_accession": "3000689", "category_aro_cvterm_id": "37033", "category_aro_name": "metronidazole", "category_aro_description": "Metronidazole is a nitroimidazole that is active against anaerobic bacteria and protozoa. It is not effective against aerobic bacteria. Nitroimidazoles act by oxidizing DNA causing strand breaks and cell death.", "category_aro_class_name": "Antibiotic"}, "41239": {"category_aro_accession": "3004115", "category_aro_cvterm_id": "41239", "category_aro_name": "nitroimidazole antibiotic", "category_aro_description": "Nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity, classified with respect to the location of the nitro functional group.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 1126.69, "max_identities": 540, "cvterm_id": "36849", "query": "MQNDKDLSTWQTFRRLWPIIAPFKAGLIVAAVALVLNAGSDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMVLRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSSALITVVREGASIIGLFVMMFYYSWQLSLILIVLAPIVSVAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLMFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDTLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGTRVIERAKGNLKFENVTFTYPGREVAALRNINLDIPEGKTVALVGRSGSGKSTIASLITRFYDVDEGQILLDGHDLREYKLSSLRDQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVMLSGGQRQRIAIARALLRNSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGRIVERGTHHDLLEHKGVYAQLHKMQFGE", "match": "M NDKDLSTWQTFRRLWP IAPFKAGLIVA VAL+LNA SDTFMLSLLKPLLDDGFGKTDRSVL+WMPLVVIGLM+LRGITSY+SSYCISWVSGKVVMTMRRRLFGHMMGMPV+FFDKQSTGTLLSRITYDSEQVASSSS ALITVVREGASIIGLF+MMFYYSWQLS+ILIVLAPIVS+AIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVL+FGGQEVETKRFDKVSN+MRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMD+LTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLF ILDSEQEKDEG RVIERA G+++F NVTFTYPGR+V ALRNINL IP GKTVALVGRSGSGKSTIASLITRFYD+DEG+IL+DGHDLREY L+SLR+QVALVSQNVHLFNDTVANNIAYARTE+YSREQIEEAARMAYAMDFINKMDNGLDT+IGENGV+LSGGQRQRIAIARALLR+SPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIE+ADEIVVVEDG IVERGTH+DLLEH+GVYAQLHKMQFG+", "sequence_from_db": "MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ", "sequence_from_broadstreet": "MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ", "dna_sequence_from_broadstreet": "ATGCATAACGACAAAGATCTCTCTACGTGGCAGACATTCCGCCGACTGTGGCCAACCATTGCGCCTTTCAAAGCGGGTCTGATCGTGGCGGGCGTAGCGTTAATCCTCAACGCAGCCAGCGATACCTTCATGTTATCGCTCCTTAAGCCACTTCTTGATGATGGCTTTGGTAAAACAGATCGCTCCGTGCTGGTGTGGATGCCGCTGGTGGTGATCGGGCTGATGATTTTACGTGGTATCACCAGCTATGTCTCCAGCTACTGTATCTCCTGGGTATCAGGAAAGGTGGTAATGACCATGCGTCGCCGCCTGTTTGGTCACATGATGGGAATGCCAGTTTCATTCTTTGACAAACAGTCAACGGGTACGCTGTTGTCACGTATTACCTACGATTCCGAACAGGTTGCTTCTTCTTCTTCCGGCGCACTGATTACTGTTGTGCGTGAAGGTGCGTCGATCATCGGCCTGTTCATCATGATGTTCTATTACAGTTGGCAACTGTCGATCATTTTGATTGTGCTGGCACCGATTGTTTCGATTGCGATTCGCGTTGTATCGAAGCGTTTTCGCAACATCAGTAAAAACATGCAGAACACCATGGGGCAGGTGACCACCAGCGCAGAACAAATGCTGAAGGGCCACAAAGAAGTATTGATTTTCGGTGGTCAGGAAGTGGAAACGAAACGCTTTGATAAAGTCAGCAACCGAATGCGTCTTCAGGGGATGAAAATGGTTTCAGCCTCTTCCATCTCTGATCCGATCATTCAGCTGATCGCCTCTTTGGCGCTGGCGTTTGTTCTGTATGCGGCGAGCTTCCCAAGTGTCATGGATAGCCTGACTGCCGGTACGATTACCGTTGTTTTCTCTTCAATGATTGCACTGATGCGTCCGCTGAAATCGCTGACCAACGTTAACGCCCAGTTCCAGCGCGGTATGGCGGCTTGTCAGACGCTGTTTACCATTCTGGACAGTGAGCAGGAGAAAGATGAAGGTAAGCGCGTGATCGAGCGTGCGACTGGCGACGTGGAATTCCGCAATGTCACCTTTACTTATCCGGGACGTGACGTACCTGCATTGCGTAACATCAACCTGAAAATTCCGGCAGGGAAGACGGTTGCTCTGGTTGGACGCTCTGGTTCGGGTAAATCAACCATCGCCAGCCTGATCACGCGTTTTTACGATATTGATGAAGGCGAAATCCTGATGGATGGTCACGATCTGCGCGAGTATACCCTGGCGTCGTTACGTAACCAGGTTGCTCTGGTGTCGCAGAATGTCCATCTGTTTAACGATACGGTTGCTAACAACATTGCTTACGCACGGACTGAACAGTACAGCCGTGAGCAAATTGAAGAAGCGGCGCGTATGGCCTACGCCATGGACTTCATCAATAAGATGGATAACGGTCTCGATACAGTGATTGGTGAAAACGGCGTGCTGCTCTCTGGCGGTCAGCGTCAGCGTATTGCTATCGCTCGAGCCTTGTTGCGTGATAGCCCGATTCTGATTCTGGACGAAGCTACCTCGGCTCTGGATACCGAATCCGAACGTGCGATTCAGGCGGCACTGGATGAGTTGCAGAAAAACCGTACCTCTCTGGTGATTGCCCACCGCTTGTCTACCATTGAAAAGGCAGACGAAATCGTGGTCGTCGAGGATGGTGTCATTGTGGAACGCGGTACGCATAACGATTTGCTTGAGCACCGCGGCGTTTACGCGCAACTTCACAAAATGCAGTTTGGCCAATGA", "partial": "0", "query_start": 227800, "query_end": 229545, "orf_dna_sequence": "ATGCAGAACGATAAAGATCTCTCCACGTGGCAGACCTTCCGCCGACTTTGGCCGATTATCGCGCCGTTTAAAGCCGGGCTAATCGTAGCGGCGGTGGCGTTGGTGCTTAACGCGGGCAGTGACACCTTCATGTTATCGCTTCTTAAACCGTTATTGGATGATGGTTTTGGTAAAACGGATCGCTCAGTGCTGCTATGGATGCCGCTGGTGGTTATCGGCCTGATGGTGCTGCGTGGGATCACCAGCTACATCTCGAGCTATTGTATTTCCTGGGTTTCCGGCAAAGTGGTGATGACCATGCGTCGTCGCCTGTTCGGCCACATGATGGGTATGCCGGTGGCCTTCTTTGACAAGCAGTCTACCGGAACGCTGCTGTCACGCATCACCTATGATTCTGAGCAGGTCGCCTCCTCTTCTTCCAGCGCGCTGATCACCGTGGTCCGCGAAGGAGCATCGATTATCGGTCTGTTCGTGATGATGTTCTATTACAGCTGGCAGCTGTCGCTGATCCTGATCGTACTGGCGCCGATTGTGTCGGTGGCGATCCGCGTGGTCTCCAAGCGTTTTCGCAATATCAGTAAGAATATGCAGAACACGATGGGGCAGGTCACCACCAGCGCCGAGCAGATGCTGAAAGGGCACAAAGAGGTGCTGATGTTTGGCGGCCAGGAAGTGGAAACCAAACGTTTTGATAAAGTCAGCAATAAAATGCGTCTGCAGGGGATGAAGATGGTTTCCGCCTCGTCTATCTCCGACCCGATCATTCAGCTTATCGCCTCCCTGGCGCTGGCCTTTGTCCTGTATGCCGCCAGCTTCCCGAGCGTGATGGACACCCTGACCGCCGGGACCATTACCGTGGTCTTCTCCTCGATGATTGCGCTGATGCGTCCGCTGAAGTCGCTGACCAACGTCAATGCCCAGTTCCAGCGCGGGATGGCGGCGTGCCAGACGCTGTTTGCGATCCTCGATTCCGAGCAGGAAAAAGACGAAGGTACGCGGGTCATTGAGCGGGCGAAAGGCAATCTCAAGTTCGAGAACGTCACCTTTACCTACCCGGGTCGCGAAGTGGCCGCGCTGCGCAATATCAATCTCGATATCCCGGAAGGGAAAACAGTGGCGCTGGTGGGGCGCTCAGGGTCGGGTAAATCGACCATTGCCAGCCTGATCACCCGCTTCTACGATGTCGACGAGGGGCAGATCCTGCTGGATGGCCACGACCTGCGCGAGTACAAGCTGAGCTCGCTGCGCGACCAGGTGGCGCTGGTTTCACAAAACGTGCATCTGTTCAACGATACCGTCGCCAACAATATCGCCTATGCCCGTACCGAAGAGTACAGCCGCGAGCAGATTGAAGAGGCCGCGCGCATGGCCTACGCCATGGATTTCATTAACAAGATGGATAATGGTCTGGATACCATCATCGGCGAGAATGGCGTGATGCTGTCCGGCGGCCAGCGCCAGCGTATTGCTATTGCCCGCGCGCTGCTGCGTAACAGCCCGATCCTGATCCTCGATGAAGCCACCTCGGCGCTGGATACCGAGTCCGAGCGTGCTATTCAGGCGGCGCTGGATGAGCTGCAGAAAAACCGTACCTCGCTGGTTATCGCTCACCGTCTGTCGACCATTGAGCAGGCTGATGAAATCGTGGTGGTTGAAGACGGGCGGATCGTGGAGCGCGGAACGCACCATGACCTGCTGGAGCATAAGGGCGTGTACGCCCAGCTGCATAAGATGCAATTCGGCGAATGA", "orf_prot_sequence": "MQNDKDLSTWQTFRRLWPIIAPFKAGLIVAAVALVLNAGSDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMVLRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSSALITVVREGASIIGLFVMMFYYSWQLSLILIVLAPIVSVAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLMFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDTLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGTRVIERAKGNLKFENVTFTYPGREVAALRNINLDIPEGKTVALVGRSGSGKSTIASLITRFYDVDEGQILLDGHDLREYKLSSLRDQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVMLSGGQRQRIAIARALLRNSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGRIVERGTHHDLLEHKGVYAQLHKMQFGE", "perc_identity": 92.78}}, "NODE_9_length_203843_cov_42.4911_20 # 15303 # 15935 # 1 # ID=9_20;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.518": {"gnl|BL_ORD_ID|818|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 15303, "orf_end": 15935, "orf_from": "NODE_9_length_203843_cov_42.4911_20", "model_name": "CRP", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "869", "pass_evalue": "n/a", "pass_bitscore": "400", "ARO_accession": "3000518", "ARO_name": "CRP", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35930": {"category_aro_accession": "0000011", "category_aro_cvterm_id": "35930", "category_aro_name": "cloxacillin", "category_aro_description": "Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections.", "category_aro_class_name": "Antibiotic"}, "35973": {"category_aro_accession": "0000056", "category_aro_cvterm_id": "35973", "category_aro_name": "oxacillin", "category_aro_description": "Oxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.31251e-158, "bit_score": 432.95, "max_identities": 208, "cvterm_id": "36839", "query": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "match": "MVLGKPQTDPTLEWFLSHCHIHKYPSKS LIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLS+QMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "sequence_from_db": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "sequence_from_broadstreet": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "dna_sequence_from_broadstreet": "ATGGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCCAAGAGCAAGCTTATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCTCTGTGGCAGTGCTGATCAAAGACGAAGAGGGTAAAGAAATGATCCTCTCCTATCTGAATCAGGGTGATTTTATTGGCGAACTGGGCCTGTTTGAAGAGGGCCAGGAACGTAGCGCATGGGTACGTGCGAAAACCGCCTGTGAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGATTCAGGTAAACCCGGACATTCTGATGCGTTTGTCTGCACAGATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCAACCTGGCGTTCCTCGACGTGACGGGCCGCATTGCACAGACTCTGCTGAATCTGGCAAAACAACCAGACGCTATGACTCACCCGGACGGTATGCAAATCAAAATTACCCGTCAGGAAATTGGTCAGATTGTCGGCTGTTCTCGTGAAACCGTGGGACGCATTCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCGTTAA", "partial": "0", "query_start": 15303, "query_end": 15932, "orf_dna_sequence": "ATGGTGCTTGGCAAACCGCAAACAGACCCTACCCTTGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCAAAGAGCACGCTGATCCACCAGGGTGAAAAAGCAGAAACGCTGTACTACATCGTTAAAGGCTCCGTGGCTGTACTCATCAAGGATGAAGAAGGTAAAGAGATGATCCTCTCCTACCTCAACCAGGGCGATTTCATCGGTGAATTAGGCCTGTTTGAAGAGGGTCAGGAACGTAGCGCCTGGGTACGGGCGAAAACCGCATGTGAAGTGGCCGAAATCTCTTATAAGAAATTCCGTCAGCTGATCCAGGTGAACCCGGACATTCTGATGCGTCTCTCTTCGCAAATGGCTCGCCGTCTGCAGGTCACGTCTGAGAAAGTGGGCAACCTGGCCTTCCTCGACGTGACGGGCCGTATCGCCCAGACGCTGCTGAACCTGGCGAAGCAACCGGATGCCATGACCCACCCGGACGGTATGCAAATTAAAATTACCCGCCAGGAAATTGGTCAGATCGTCGGCTGCTCTCGTGAAACCGTTGGTCGTATTTTGAAAATGCTGGAAGATCAGAACCTGATTTCCGCGCACGGTAAAACCATCGTCGTCTACGGCACCCGTTAA", "orf_prot_sequence": "MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR", "perc_identity": 99.05}}, "NODE_9_length_203843_cov_42.4911_123 # 130217 # 131200 # -1 # ID=9_123;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.603": {"gnl|BL_ORD_ID|1977|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 130217, "orf_end": 131200, "orf_from": "NODE_9_length_203843_cov_42.4911_123", "model_name": "pmrF", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2014", "pass_evalue": "n/a", "pass_bitscore": "550", "ARO_accession": "3003578", "ARO_name": "PmrF", "ARO_category": {"41433": {"category_aro_accession": "3004269", "category_aro_cvterm_id": "41433", "category_aro_name": "pmr phosphoethanolamine transferase", "category_aro_description": "This family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane.", "category_aro_class_name": "AMR Gene Family"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 577.785, "max_identities": 272, "cvterm_id": "36849", "query": "MLTYPPVKKVSVVIPVYNEQDSLPELLRRTDAACATLGRQYEILLIDDGSSDDSARMLTEAAEAEGSHVVAVLLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSIFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIIDAMLNCHERSTFIPILANTFARRAVEIPVMHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSIFGSVIALLGFAFGLLLVVLRLAFGPQWAAEGVFMLFAVLFMFIGAQFVGMGLLGEYIGRIYNDVRARPRYFIQRVVRQPETASKEED", "match": "M    PVKKVSVVIPVYNEQ+SLPEL+RRT  AC +LG++YEILLIDDGSSD+SA ML EA++AE SH+V++LLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDS FRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHI+DAML+CHERSTFIPILAN FARRA+EIPV HAEREFG+SKYSFMRLINLMYDLVTCLTTTPLR+LS+ GS+IA+ GF+  +LLV+LRL FGPQWAAEGVFMLFAVLF FIGAQF+GMGLLGEYIGRIY DVRARPRYF+Q+V+R    +SKE +", "sequence_from_db": "MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIR---PSSKENE", "sequence_from_broadstreet": "MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE", "dna_sequence_from_broadstreet": "ATGTTTGAAATCCACCCTGTTAAGAAAGTCTCGGTGGTTATTCCCGTTTATAACGAGCAGGAAAGCTTACCGGAATTAATCAGGCGCACCACCACAGCCTGTGAATCGTTGGGGAAAGAGTATGAGATCCTGCTGATTGATGACGGCAGTAGCGATAATTCCGCGCATATGCTGGTCGAAGCCTCACAAGCGGAGAACAGCCATATTGTGTCTATTTTGCTTAACCGCAATTACGGGCAACATTCAGCGATTATGGCGGGATTCAGTCACGTTACTGGCGACTTAATTATTACCCTTGATGCCGATCTCCAGAATCCGCCAGAAGAAATCCCCCGCCTGGTGGCAAAAGCCGATGAAGGTTACGACGTGGTAGGGACTGTACGCCAGAACCGCCAGGACAGCTGGTTTCGTAAAACCGCTTCGAAGATGATTAACCGGCTTATTCAGCGCACCACTGGCAAAGCGATGGGTGATTACGGTTGTATGCTGCGCGCCTATCGCCGTCATATTGTCGATGCGATGTTGCACTGCCATGAACGCAGCACCTTTATCCCGATTCTGGCGAATATCTTCGCCCGCCGTGCCATTGAAATTCCAGTACATCATGCCGAGCGTGAGTTTGGTGAATCCAAATACAGTTTTATGCGCCTGATTAATTTGATGTACGACCTGGTGACCTGCCTTACCACAACGCCGCTACGTATGCTGAGTCTGCTCGGCAGCATTATTGCGATTGGAGGTTTTAGCATTGCGGTGCTGCTGGTGATTTTACGCCTGACCTTCGGACCACAATGGGCGGCAGAAGGCGTCTTTATGCTATTTGCCGTGCTGTTTACTTTTATTGGCGCTCAGTTTATCGGCATGGGATTACTCGGTGAATATATCGGCAGGATCTACACCGATGTCCGCGCCCGCCCCCGCTATTTTGTTCAGCAAGTTATCCGTCCATCCAGCAAGGAAAATGAATAA", "partial": "0", "query_start": 130217, "query_end": 131191, "orf_dna_sequence": "ATGCTTACTTACCCTCCCGTGAAGAAGGTCTCGGTGGTTATCCCGGTTTATAACGAACAGGATAGCCTGCCGGAACTGCTTCGTCGTACGGATGCCGCCTGCGCCACCCTGGGGCGGCAATATGAAATTCTGTTGATCGACGATGGCAGCAGCGACGATTCCGCGCGCATGCTCACCGAAGCCGCCGAGGCGGAAGGCAGCCACGTCGTCGCCGTGCTGTTAAACCGTAACTACGGCCAGCACTCGGCGATCATGGCCGGCTTCAGCCATGTAACCGGCGATCTGATTATTACCCTCGACGCCGACCTGCAAAACCCGCCGGAGGAGATCCCGCGGCTGGTGGCGAAGGCTGATGAAGGTTACGACGTGGTGGGCACCGTCCGCCAGAACCGTCAGGACAGCATCTTCCGTAAAACCGCGTCGAAGATGATCAACCGCCTGATCCAGCGCACCACCGGCAAAGCGATGGGCGACTACGGCTGCATGCTGCGCGCTTACCGCCGCCATATCATCGACGCCATGCTCAACTGCCATGAGCGCAGCACCTTTATCCCGATCCTGGCGAATACCTTCGCCCGGCGCGCGGTGGAGATCCCGGTGATGCACGCCGAGCGCGAATTCGGCGACTCCAAATACAGCTTTATGCGCCTGATCAACCTGATGTACGACCTGGTGACCTGTCTGACCACCACGCCGCTGCGTCTGCTCAGCATTTTCGGCAGCGTGATTGCCCTGCTGGGCTTCGCCTTCGGCCTGCTGCTGGTGGTGCTGCGTCTGGCCTTTGGCCCGCAGTGGGCGGCGGAAGGGGTGTTTATGCTCTTCGCCGTGCTGTTCATGTTCATCGGCGCCCAGTTTGTCGGTATGGGCCTGCTCGGGGAGTATATCGGCCGCATCTATAACGACGTGCGCGCCCGCCCCCGCTACTTTATTCAACGTGTTGTTCGCCAGCCGGAAACGGCATCTAAAGAGGAAGATCGTTCATGA", "orf_prot_sequence": "MLTYPPVKKVSVVIPVYNEQDSLPELLRRTDAACATLGRQYEILLIDDGSSDDSARMLTEAAEAEGSHVVAVLLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSIFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIIDAMLNCHERSTFIPILANTFARRAVEIPVMHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSIFGSVIALLGFAFGLLLVVLRLAFGPQWAAEGVFMLFAVLFMFIGAQFVGMGLLGEYIGRIYNDVRARPRYFIQRVVRQPETASKEEDRS", "perc_identity": 83.69}}, "NODE_11_length_157792_cov_39.2115_112 # 108413 # 108787 # 1 # ID=11_112;partial=00;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.509": {"gnl|BL_ORD_ID|1815|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 108413, "orf_end": 108787, "orf_from": "NODE_11_length_157792_cov_39.2115_112", "model_name": "marA", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1922", "pass_evalue": "n/a", "pass_bitscore": "230", "ARO_accession": "3000263", "ARO_name": "marA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "41445": {"category_aro_accession": "3004281", "category_aro_cvterm_id": "41445", "category_aro_name": "General Bacterial Porin with reduced permeability to beta-lactams", "category_aro_description": "These are GBPs that are associated with decreased susceptibility to beta-lactams either through mutations in the porin protein, absence of the porin protein, or expression of the porin protein.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}, "36383": {"category_aro_accession": "3000244", "category_aro_cvterm_id": "36383", "category_aro_name": "reduced permeability to antibiotic", "category_aro_description": "Reduction in permeability to antibiotic, generally through reduced production of porins, can provide resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.82183e-86, "bit_score": 243.432, "max_identities": 115, "cvterm_id": "36839", "query": "MSRRNNDAITIHSILSWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKLTEIAQKLKQSNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRITNVPGESRYLHPLNN", "match": "MSRRN DAITIHSIL WIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRK+TEIAQKLK+SNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYR+TN+ GESR+LHPLN+", "sequence_from_db": "MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNH", "sequence_from_broadstreet": "MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNHYNS", "dna_sequence_from_broadstreet": "ATGTCCAGACGCAATACTGACGCTATTACCATTCATAGCATTTTGGACTGGATCGAGGACAACCTGGAATCGCCACTGTCACTGGAGAAAGTGTCAGAGCGTTCGGGTTACTCCAAATGGCACCTGCAACGGATGTTTAAAAAAGAAACCGGTCATTCATTAGGCCAATACATCCGCAGCCGTAAGATGACGGAAATCGCGCAAAAGCTGAAGGAAAGTAACGAGCCGATACTCTATCTGGCAGAACGATATGGCTTCGAGTCGCAACAAACTCTGACCCGAACCTTCAAAAATTACTTTGATGTTCCGCCGCATAAATACCGGATGACCAATATGCAGGGCGAATCGCGCTTTTTACATCCATTAAATCATTACAACAGCTAG", "partial": "0", "query_start": 108413, "query_end": 108784, "orf_dna_sequence": "ATGTCCAGACGTAATAATGACGCCATCACTATCCATAGTATTTTGTCGTGGATCGAGGATAACCTGGAATCGCCCCTGTCGCTGGAAAAAGTGTCTGAGCGCTCCGGTTACTCTAAGTGGCACCTGCAACGTATGTTTAAGAAAGAGACCGGCCATTCCCTCGGCCAGTACATCCGCAGCCGCAAGCTGACGGAGATTGCGCAGAAGCTCAAGCAGAGTAATGAGCCAATCCTGTACCTGGCGGAACGCTATGGTTTCGAGTCGCAGCAGACCCTGACGCGAACGTTCAAGAACTATTTCGATGTTCCGCCCCACAAGTATCGCATAACGAATGTACCTGGCGAATCCCGCTATCTACATCCGCTAAATAACTGA", "orf_prot_sequence": "MSRRNNDAITIHSILSWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKLTEIAQKLKQSNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRITNVPGESRYLHPLNN", "perc_identity": 92.74}}, "NODE_11_length_157792_cov_39.2115_132 # 128890 # 129750 # 1 # ID=11_132;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.628": {"gnl|BL_ORD_ID|539|hsp_num:0": {"type_match": "Perfect", "model_id": "578", "orf_strand": "+", "orf_start": 128890, "orf_end": 129750, "orf_from": "NODE_11_length_157792_cov_39.2115_132", "model_name": "SHV-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "550", "ARO_accession": "3001070", "ARO_name": "SHV-11", "ARO_category": {"36024": {"category_aro_accession": "3000015", "category_aro_cvterm_id": "36024", "category_aro_name": "SHV beta-lactamase", "category_aro_description": "SHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 580.867, "max_identities": 286, "cvterm_id": "35915", "query": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "match": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "sequence_from_db": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "sequence_from_broadstreet": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "dna_sequence_from_broadstreet": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAGCGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGCATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "partial": "0", "query_start": 128890, "query_end": 129747, "orf_dna_sequence": "ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAACAAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAACGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAGATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACATCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCCGCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTGCTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAGATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCCAGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGATCGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTGGCGAACGGGGTGCGCGCGGGATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACGCCGGCGAGTATGGCCGAGCGAAATCAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA", "orf_prot_sequence": "MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR", "perc_identity": 100.0}}, "NODE_19_length_86672_cov_43.8582_38 # 39587 # 39811 # -1 # ID=19_38;partial=00;start_type=ATG;rbs_motif=AGxAG;rbs_spacer=5-10bp;gc_cont=0.551": {"gnl|BL_ORD_ID|608|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "tet(31)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "800", "model_id": "640", "ARO_accession": "3000476", "ARO_name": "tet(31)", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.286606, "max_identities": 12, "bit_score": 25.409, "cvterm_id": "40299", "query": "GQLSMKNVFPTLAVLFAIFSLTGCGLKGPL", "match": "G+L M N + T+A+L      TG GL  P+", "sequence_from_db": "GKLIMMNRYITIALLITFLDATGMGLIMPV", "sequence_from_broadstreet": "MIGKLIMMNRYITIALLITFLDATGMGLIMPVLPTLLEEFSVKESIATHYGFILAIYALMQVIFAPILGQLSDKFGRKPVLILSLIGAVCDYTLLSFSSALWMLYLGRMIAGISAATGAVAASMVADHTKKAERTKWFGKLGAAFGAGLIAGPAIGGFIGQYSAHFPFIIAAILNAIALIMVIILFPKEQSRPKEIEQDQSKIHEKTTINAPLIHILKPVLLLLMLFFTVQLIGQIPASTWVLFTEYRFEWNTFNIGLSLAGLGLMHIIFQAFVAGYIASRWKNETVFILGFILDASAFLLLAFISQVWLVIPTLILLAGGGIALPALQGLISIKTADEHQGKIQGIMVSLTNITGIIGPPIFAFSFAKTVTNWDGTLWLIGAVLYSILLGLYFLYQKIRAYKQLKSQTA", "dna_sequence_from_broadstreet": "ATGATAGGGAAGCTTATAATGATGAATCGCTATATCACAATCGCCCTCTTAATTACCTTCCTAGATGCAACAGGAATGGGCTTAATCATGCCTGTATTACCAACACTTTTAGAAGAGTTCTCTGTCAAAGAGTCTATCGCCACTCATTATGGTTTTATCCTCGCAATCTATGCGCTGATGCAAGTTATTTTTGCACCAATATTAGGACAACTCTCGGATAAATTTGGCAGAAAACCGGTCTTGATTCTCTCATTAATAGGCGCTGTTTGTGATTACACCCTACTCTCATTTTCTAGCGCCTTATGGATGCTCTATCTAGGGAGAATGATTGCCGGCATTTCTGCTGCAACAGGAGCCGTAGCAGCATCAATGGTCGCAGATCACACAAAAAAAGCAGAGAGAACTAAATGGTTTGGAAAGTTAGGCGCAGCTTTTGGGGCGGGACTCATTGCCGGACCCGCTATTGGTGGATTTATCGGACAATATTCTGCACATTTCCCCTTTATCATTGCCGCAATTTTAAATGCCATTGCTCTTATCATGGTCATTATCCTCTTCCCTAAAGAGCAATCACGCCCAAAAGAAATCGAGCAAGATCAATCTAAAATTCATGAAAAAACCACCATCAATGCCCCGCTAATTCATATTCTCAAACCCGTTTTGCTACTTCTCATGCTGTTTTTTACAGTACAACTCATCGGACAAATCCCTGCATCAACTTGGGTTCTATTTACTGAGTACCGTTTTGAGTGGAATACCTTTAACATTGGTTTATCCCTTGCAGGGCTAGGGTTAATGCATATTATCTTTCAGGCTTTTGTCGCAGGATATATCGCATCTCGCTGGAAAAATGAAACCGTATTTATTCTCGGATTTATACTAGATGCGAGCGCATTCTTATTACTGGCCTTTATCTCTCAAGTTTGGCTGGTAATTCCTACATTGATCTTATTAGCAGGAGGAGGCATCGCCTTACCGGCATTACAAGGATTAATCTCTATAAAGACAGCAGATGAACATCAAGGAAAGATACAAGGTATCATGGTTAGCCTCACTAATATTACCGGAATAATTGGACCGCCCATTTTTGCATTTTCCTTTGCAAAAACGGTTACAAACTGGGATGGCACACTTTGGCTAATCGGTGCTGTACTCTATAGCATTTTATTAGGTCTCTATTTTCTCTATCAAAAGATACGCGCCTATAAACAACTTAAGTCTCAAACTGCTTAA", "partial": "0", "query_start": 39596, "query_end": 39685, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 40.0}, "gnl|BL_ORD_ID|1111|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "mdsC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "940", "model_id": "1180", "ARO_accession": "3000791", "ARO_name": "mdsC", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.591105, "max_identities": 23, "bit_score": 24.6386, "cvterm_id": "35734", "query": "NHGQLSMKNVF------PTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRG", "match": "N G   MK  F       TLA L  + +L GC +  P +  PA  TA     P      S  PD  D G", "sequence_from_db": "NDGNGIMKITFTGYRQTATLATLAFVTTLAGCTM-APKHERPASPTA--MVYPYATSTVSGAPDAADIG", "sequence_from_broadstreet": "MRTALIRMISKHNDGNGIMKITFTGYRQTATLATLAFVTTLAGCTMAPKHERPASPTAMVYPYATSTVSGAPDAADIGWRDFFHDPLLQELIAIALRNNRDLRKAGLNVEAARALYRIQRAEMLPTLGIATAMDASRTPADLSVMDESEINRRYEAAGATTAWELDLWGRVRSLSDQALAAYMALDETYIAARMSLVSEVASAWLTLRADRELLRLTEDTLAAQKSSYTLTTQLARTGNATQLDLRMAEIALRSAEINRAAYTRQLARDRNALELLLGQPLTPELSRRLNEAVTLTEGAIPTTLPGGLPSDLLVRRPDIRAAEYRLRGANARIGAARAAFFPTISLTGSAGTASASLSGLFEPGSGSWRFLPQITLPLFHGGALRADLDRAHVQKQIEIARYENVIQQAFRDVADGLAGQRTLNDQVQSEQRAVEASQIAYELAGLRFQEGVDDYLTLLDTHRMLYGAQQRLVRTRLMQQLNIINLYKALGGGWREYSEKKQG", "dna_sequence_from_broadstreet": "GTGAGAACCGCGTTGATTCGCATGATCAGCAAGCATAATGATGGGAATGGCATAATGAAGATCACTTTTACAGGCTATCGGCAGACCGCCACGCTGGCGACGCTTGCTTTCGTCACCACGCTTGCTGGCTGTACGATGGCGCCGAAGCACGAACGCCCCGCATCGCCGACTGCGATGGTCTATCCCTACGCAACGTCAACCGTTTCTGGCGCGCCGGATGCCGCTGACATTGGCTGGCGTGATTTCTTCCACGATCCGCTTCTACAGGAACTGATTGCGATCGCGTTACGCAATAATCGGGATTTACGCAAGGCAGGGCTCAATGTTGAAGCCGCCCGGGCGTTATACCGCATTCAGCGCGCGGAGATGCTGCCGACGCTCGGCATCGCCACCGCCATGGACGCCAGTCGCACTCCCGCCGATCTCAGCGTCATGGACGAGTCTGAGATTAACCGACGCTACGAGGCGGCTGGGGCGACGACGGCCTGGGAACTGGATCTCTGGGGGCGAGTGCGAAGCCTTAGCGACCAGGCATTAGCCGCCTATATGGCGCTTGATGAGACGTACATTGCGGCGCGAATGAGCCTGGTTTCCGAAGTCGCCAGCGCCTGGCTGACGCTACGGGCTGACCGGGAGCTGCTGCGCTTAACCGAGGATACGCTGGCCGCGCAAAAAAGTTCATACACATTGACGACCCAGCTTGCCCGGACAGGTAACGCCACACAGCTCGATCTGCGTATGGCGGAGATCGCGCTGCGTTCTGCCGAAATCAATCGCGCGGCGTATACGCGACAGTTGGCGCGGGATCGTAACGCGCTGGAATTGCTGTTGGGCCAGCCGCTCACGCCTGAACTGTCGCGTCGACTAAACGAAGCGGTCACGCTTACAGAAGGCGCGATCCCGACCACACTGCCAGGCGGATTACCGTCAGATCTGCTGGTACGCCGCCCGGATATTCGCGCCGCCGAGTACAGGCTGCGCGGCGCAAACGCCCGGATAGGCGCAGCGCGCGCCGCCTTCTTCCCGACCATCAGCCTGACAGGCTCGGCGGGAACGGCCAGCGCGTCTCTTAGCGGACTCTTTGAACCGGGATCGGGAAGCTGGCGTTTTCTACCGCAAATCACCTTGCCTCTCTTTCACGGCGGCGCATTACGCGCTGACCTGGATAGGGCGCATGTCCAAAAACAGATTGAAATCGCCAGGTATGAAAACGTTATTCAGCAAGCCTTTCGCGACGTGGCGGATGGTCTGGCGGGACAGCGTACGCTGAATGACCAGGTGCAATCAGAACAACGCGCGGTTGAAGCCAGTCAAATCGCCTATGAGCTGGCCGGACTCCGTTTTCAGGAAGGCGTCGATGACTACCTTACGCTGCTTGATACCCATCGTATGCTTTATGGCGCACAACAGCGCCTGGTACGCACACGTCTCATGCAACAGTTAAATATCATTAACCTGTATAAAGCATTAGGCGGCGGTTGGCGGGAATACAGTGAGAAAAAGCAAGGTTAG", "partial": "0", "query_start": 39590, "query_end": 39778, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 33.33}, "gnl|BL_ORD_ID|1382|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "facT", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1050", "model_id": "1469", "ARO_accession": "3001313", "ARO_name": "facT", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "37619": {"category_aro_accession": "3001220", "category_aro_cvterm_id": "37619", "category_aro_name": "factumycin", "category_aro_description": "Factumycin is a kirromycin-like antibiotic produced by Kitasatospora setae and Streptomyces strains. Its biosynthetic cluster has been characterized which has interesting acetyl transferase domains in trans, or outside of the polyketide synthase domains. Factumycin has specific, rather than broad spectrum,  antibacterial properties, especially targeting various Acinetobacter baumanii strains.", "category_aro_class_name": "Antibiotic"}, "37618": {"category_aro_accession": "3001219", "category_aro_cvterm_id": "37618", "category_aro_name": "elfamycin antibiotic", "category_aro_description": "Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.753437, "max_identities": 11, "bit_score": 24.2534, "cvterm_id": "37730", "query": "GCGLKGPLYFPPADKTAPPPTKPVNPGIQSATP", "match": "G  + G L+F      A P  + V P +QS +P", "sequence_from_db": "GVAVIGSLFFAALAGNAGPQAERVAPTVQSVSP", "sequence_from_broadstreet": "MNKAGQAEKPAAAGPPATPETPEPDPKRWLALTVLLVATFMDLLDANIITVAIPSIQRDLGASTFAIQAMTAGYTLSFAVLLITGGRLGDIFGRKRMFLVGVGGFVLASAMCAAAPSTDLLVVARALQGLTAAVMVPQVLALIHVSFAPQEIGRVVSLYASMVGLAIVSGPLIGGALISWNPLDLGWRSIFVVNLPVGVLALVGAAKWMRESSSPHAKRLDIAGMLLIVLGLLLLMVPLTLGRELDWPVWSIVSLVAAAPVLVLFVVYERHKTAKDGSPLVTLSLFKVRAFGAGIGVQLLFSAIPAGFFLSWTLYLQAGLGWSALHTGLTAIPFSLCVPIVGGLAVRRLSPLYGRYCLLAGAVLMLAGILSYAWAADRFGTDITSWHAIPSMLLIGSGMGMLMPPLTALVLREVQPQEAGAASGIINATGQLGAALGVAVIGSLFFAALAGNAGPQAERVAPTVQSVSPRQASDLRDCATEALGQDDLAKVPDICSTLVQGADDGTRDTINGALGEIRAKTFVSTYSETLYWAAGGLVPVTALVLLLPHHRVRREEPAQ", "dna_sequence_from_broadstreet": "ATGAACAAGGCAGGGCAGGCAGAAAAGCCGGCGGCAGCCGGCCCACCTGCCACTCCCGAGACGCCCGAGCCCGACCCGAAGCGGTGGCTCGCGCTGACAGTCCTGCTGGTCGCCACCTTCATGGACCTGCTCGACGCGAACATCATCACCGTGGCCATCCCGAGCATCCAACGCGACCTCGGCGCCTCGACCTTCGCCATCCAGGCGATGACGGCCGGCTACACCCTGAGCTTCGCGGTCCTGCTGATCACCGGCGGCCGGCTCGGCGACATCTTCGGCCGCAAGCGCATGTTCCTCGTCGGCGTCGGCGGCTTCGTCCTCGCGTCCGCGATGTGCGCCGCCGCGCCGAGCACCGACTTACTCGTCGTCGCCCGCGCGCTCCAGGGCCTCACCGCCGCCGTCATGGTGCCCCAGGTGCTCGCGCTCATCCACGTCTCCTTCGCGCCCCAGGAGATCGGCCGCGTCGTCAGCCTGTACGCGAGCATGGTCGGTCTGGCCATCGTCTCCGGGCCCCTCATCGGCGGTGCGCTGATCAGCTGGAACCCGCTGGACCTCGGCTGGCGCAGCATCTTCGTGGTGAACCTGCCGGTCGGCGTGCTCGCCCTGGTCGGCGCCGCGAAGTGGATGCGGGAGTCGAGCTCCCCCCATGCGAAGCGCCTGGACATCGCCGGCATGCTGCTGATCGTGCTCGGCCTGCTGCTGCTCATGGTGCCGCTGACCCTCGGCCGCGAGCTCGACTGGCCGGTGTGGAGCATCGTCTCGCTCGTCGCCGCCGCCCCCGTCCTCGTGCTGTTCGTCGTCTACGAGCGCCACAAGACCGCCAAGGACGGCTCGCCCCTGGTGACGCTGTCCCTGTTCAAGGTCCGCGCGTTCGGCGCCGGCATCGGCGTCCAGCTCCTCTTCAGCGCCATCCCCGCGGGCTTCTTCCTCAGCTGGACCCTCTACCTCCAGGCCGGCCTCGGCTGGTCGGCCCTGCACACGGGCCTGACCGCCATCCCGTTCTCCCTGTGCGTCCCGATCGTCGGCGGTCTCGCCGTCCGCAGGCTCTCGCCGCTCTACGGCCGCTACTGCCTGCTCGCCGGTGCCGTCCTGATGCTCGCGGGCATCCTCTCCTACGCCTGGGCGGCCGACCGCTTCGGCACGGACATCACCTCCTGGCACGCGATCCCGTCCATGCTCCTGATCGGCTCCGGCATGGGCATGCTGATGCCCCCGCTGACGGCGCTGGTGCTCAGGGAGGTCCAGCCGCAGGAGGCCGGCGCCGCCTCCGGCATCATCAACGCCACCGGCCAGCTCGGTGCCGCGCTCGGCGTGGCGGTCATCGGCAGCCTCTTCTTCGCGGCCCTCGCCGGCAACGCCGGGCCGCAGGCCGAACGCGTCGCCCCCACCGTGCAGTCGGTCTCACCCCGGCAGGCCTCCGACCTCCGGGACTGCGCGACCGAGGCGCTGGGCCAGGACGACCTGGCCAAGGTCCCGGACATCTGCTCCACCCTGGTGCAGGGCGCCGACGACGGCACCCGGGATACGATCAATGGCGCGCTCGGCGAGATCCGCGCGAAGACGTTCGTGTCCACCTACAGCGAGACGCTGTACTGGGCGGCCGGTGGCCTCGTCCCGGTCACCGCCCTCGTCCTGCTCCTGCCGCACCACCGCGTCCGGCGGGAGGAACCGGCCCAGTGA", "partial": "0", "query_start": 39662, "query_end": 39760, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 33.33}, "gnl|BL_ORD_ID|451|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45385, "max_identities": 16, "bit_score": 23.483, "cvterm_id": "36804", "query": "SMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGI", "match": "+M+ + P  A+L AI +L+GCG             APPP +    GI", "sequence_from_db": "AMRVLVP--ALLVAISALSGCG----------KSEAPPPAQTPEVGI", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 39605, "query_end": 39745, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 34.04}, "gnl|BL_ORD_ID|450|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "MexA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "440", "ARO_accession": "3000377", "ARO_name": "MexA", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36689": {"category_aro_accession": "3000550", "category_aro_cvterm_id": "36689", "category_aro_name": "aztreonam", "category_aro_description": "Aztreonam was the first monobactam discovered, and is greatly effective against Gram-negative bacteria while inactive against Gram-positive bacteria. Artreonam is a poor substrate for beta-lactamases, and may even act as an inhibitor. In Gram-negative bacteria, Aztreonam interferes with filamentation, inhibiting cell division and leading to cell death.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "40362": {"category_aro_accession": "3003708", "category_aro_cvterm_id": "40362", "category_aro_name": "panipenem", "category_aro_description": "Panipenem is a carbapenem antibacterial agent with a broad spectrum of in vitro activity covering a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacterial.  It is used in combination with betamipron to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "40957": {"category_aro_accession": "3004024", "category_aro_cvterm_id": "40957", "category_aro_name": "trimethoprim-sulfamethoxazole", "category_aro_description": "An antibiotic cocktail containing the diaminopyrimidine antibiotic Trimethoprim and the sulfonamide antibiotic sulfamethoxazole (1 TMP:5 SMX).", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45385, "max_identities": 16, "bit_score": 23.483, "cvterm_id": "36804", "query": "SMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGI", "match": "+M+ + P  A+L AI +L+GCG             APPP +    GI", "sequence_from_db": "AMRVLVP--ALLVAISALSGCG----------KSEAPPPAQTPEVGI", "sequence_from_broadstreet": "MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG", "dna_sequence_from_broadstreet": "ATGCAACGAACGCCAGCCATGCGTGTACTGGTTCCGGCCCTGCTGGTCGCGATTTCGGCCCTTTCCGGGTGCGGAAAAAGCGAGGCGCCGCCGCCGGCGCAAACGCCGGAGGTCGGGATCGTGACCCTGGAAGCGCAGACGGTGACCCTGAATACCGAGCTGCCGGGCCGGACCAATGCGTTCCGCATCGCCGAGGTGCGTCCCCAGGTGAACGGCATCATCCTCAAGCGCCTGTTCAAGGAAGGCAGCGACGTCAAGGCCGGGCAGCAGCTCTACCAGATCGACCCCGCCACCTACGAGGCCGACTACCAGAGCGCCCAGGCCAACCTGGCTTCGACCCAGGAACAGGCCCAGCGCTACAAGCTGCTGGTCGCCGACCAGGCCGTGAGCAAGCAGCAGTACGCCGACGCCAATGCCGCCTACCTGCAGTCCAAGGCGGCGGTGGAGCAGGCGCGGATCAACCTGCGCTACACCAAGGTGCTGTCGCCGATCTCCGGCCGCATCGGCCGTTCCGCGGTGACCGAAGGCGCCCTGGTGACCAACGGCCAGGCCAACGCGATGGCCACCGTGCAACAGCTCGACCCGATCTACGTCGACGTCACCCAGCCGTCCACCGCCCTGCTGCGCCTGCGCCGCGAACTGGCCAGCGGCCAGTTGGAGCGCGCCGGCGACAACGCGGCGAAGGTCTCCCTGAAGCTGGAGGACGGTAGCCAATACCCGCTGGAAGGTCGCCTCGAATTCTCCGAGGTTTCCGTCGACGAAGGCACCGGCTCGGTCACCATCCGCGCCGTGTTCCCCAACCCGAACAACGAGCTGCTGCCCGGCATGTTCGTTCACGCGCAGTTGCAGGAAGGCGTCAAGCAGAAGGCCATCCTCGCTCCGCAGCAAGGCGTGACCCGCGACCTCAAGGGCCAGGCTACCGCGCTGGTGGTGAACGCGCAGAACAAGGTCGAGCTGCGGGTGATCAAGGCCGACCGGGTGATCGGCGACAAGTGGCTGGTTACCGAAGGCCTGAACGCCGGCGACAAGATCATTACCGAAGGCCTGCAGTTCGTGCAGCCGGGTGTCGAGGTGAAGACCGTGCCGGCGAAGAATGTCGCGTCCGCGCAGAAGGCCGACGCCGCTCCGGCGAAAACCGACAGCAAGGGCTGA", "partial": "0", "query_start": 39605, "query_end": 39745, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 34.04}, "gnl|BL_ORD_ID|2351|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "FRI-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "3594", "ARO_accession": "3004799", "ARO_name": "FRI-3", "ARO_category": {"42915": {"category_aro_accession": "3004796", "category_aro_cvterm_id": "42915", "category_aro_name": "FRI beta-lactamase", "category_aro_description": "FRI is a carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae.", "category_aro_class_name": "AMR Gene Family"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.97764, "max_identities": 9, "bit_score": 21.9422, "cvterm_id": "36884", "query": "NPGIQSATPDRNDRGDTGG", "match": "N  I++A PD+ D GD  G", "sequence_from_db": "NARIRAAVPDKWDVGDKTG", "sequence_from_broadstreet": "MFFLKKAQVHLFFFLCLPLNSFASQESNSIEQMRELEAAFGGRIGVYILNTKNGKEFSYRQDERFPLCSSFKAFLAASVLKKTQDKSVSLDDMMEYSGRVMEKHSPVSEKYRKTGASVRTLAKAAIQYSDNGASNLLMERYIGGPEGLTAFMRSTGDTDFRLDRWELELNSAIPGDERDTSTPKAVAMSLKNIAFGSVLDAKNKSLLQEWLKGNTTGNARIRAAVPDKWDVGDKTGTCGFYGTANDVAILWPDANSPAVMAVYTTRPNQNDKHDEAVIKNSAKIAINAVYGSYK", "dna_sequence_from_broadstreet": "ATGTTTTTTTTAAAAAAAGCGCAAGTACATTTATTTTTTTTTCTCTGTCTTCCATTGAACTCATTCGCCTCTCAGGAAAGTAATAGTATTGAGCAAATGAGGGAATTGGAAGCTGCTTTTGGGGGGCGGATAGGTGTTTATATTTTAAACACAAAGAATGGGAAAGAATTTTCCTACAGACAAGATGAGAGATTTCCTTTATGTAGTTCATTTAAGGCATTCCTCGCTGCATCCGTATTAAAAAAAACTCAGGATAAATCTGTTTCTCTTGATGATATGATGGAATATTCTGGACGTGTTATGGAAAAGCATTCTCCTGTGTCAGAAAAATACCGCAAAACAGGAGCAAGCGTGCGGACTTTGGCGAAGGCAGCAATTCAGTACAGTGACAATGGAGCTTCTAATCTATTAATGGAAAGATACATAGGAGGTCCTGAGGGTTTGACTGCATTTATGCGGTCAACGGGAGACACTGACTTCAGGCTTGATCGTTGGGAATTAGAATTAAACTCAGCTATTCCAGGCGATGAACGAGATACTTCAACTCCAAAAGCAGTGGCAATGAGCCTTAAAAATATTGCTTTTGGTTCAGTACTCGATGCTAAAAATAAATCATTGCTGCAGGAATGGCTTAAAGGCAACACTACTGGTAATGCGCGAATTAGAGCTGCGGTTCCAGATAAGTGGGATGTTGGCGATAAAACAGGCACCTGTGGTTTTTATGGTACAGCCAATGATGTTGCTATTTTATGGCCAGACGCTAATTCACCTGCAGTTATGGCTGTCTACACAACACGTCCTAATCAAAACGACAAACATGACGAAGCAGTAATTAAAAATTCTGCAAAAATAGCTATAAATGCAGTGTATGGAAGTTATAAATAA", "partial": "0", "query_start": 39734, "query_end": 39790, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 47.37}, "gnl|BL_ORD_ID|2592|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "CBP-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "3567", "ARO_accession": "3004764", "ARO_name": "CBP-1", "ARO_category": {"42877": {"category_aro_accession": "3004763", "category_aro_cvterm_id": "42877", "category_aro_name": "CBP beta-lactamase", "category_aro_description": "CBP is a class A beta-lactamase family found in C. botulinum.", "category_aro_class_name": "AMR Gene Family"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.59226, "max_identities": 8, "bit_score": 21.557, "cvterm_id": "41649", "query": "IFSLTGCG", "match": "IFSLTGCG", "sequence_from_db": "IFSLTGCG", "sequence_from_broadstreet": "MKKIVNSKLKVNKFKMCIFISILIFSLTGCGNVENKTSENTKPEIQYNSAFSKIESDYGVKLGVYAFDTETNKEVTYNADKRFAYCSTFKSLISGAILQKYSSDQLKQVIKYSPKDVLSYAPVTKNHVDKGMTIEELCDAAVRFSDNTAANLLINLIGGPNGFKSALNQLGDTVTEPARIEPELNVATPGDNRDTSTPRQLSIDLKEYTTGNILSDDKKKILINWMSGNATGDKLIRAGAPKDWMVSDKSGTGSYGTRNDIAIVIPPNKKPIFIAILSSKNDKDAKYDDKTISEASKIVFDYFINTRK", "dna_sequence_from_broadstreet": "ATGAAAAAAATAGTAAACTCAAAATTAAAGGTAAATAAATTTAAAATGTGTATATTTATATCAATTCTTATATTTTCTCTTACTGGATGTGGAAATGTAGAAAATAAAACTTCTGAAAATACAAAACCTGAGATACAATATAATTCAGCATTTTCAAAAATTGAAAGTGATTATGGTGTTAAACTTGGTGTATATGCTTTTGATACAGAAACAAATAAAGAAGTTACATATAATGCTGATAAGAGATTCGCTTACTGTTCTACCTTTAAATCTTTAATATCCGGTGCGATTTTACAAAAATATTCATCAGACCAACTTAAACAAGTAATTAAATATAGCCCAAAAGATGTACTGTCTTATGCACCAGTTACAAAAAATCATGTTGATAAAGGTATGACTATTGAAGAACTTTGCGATGCGGCAGTACGCTTTAGTGATAATACAGCTGCAAATCTTTTGATTAATCTTATAGGTGGACCTAATGGTTTTAAATCAGCACTTAATCAATTAGGTGACACAGTTACAGAACCTGCACGTATCGAACCAGAACTAAATGTTGCTACACCTGGAGATAATAGGGATACTAGTACTCCAAGACAATTATCAATTGATTTAAAAGAATACACAACTGGAAATATATTATCAGATGATAAGAAAAAAATTCTTATTAATTGGATGTCAGGAAATGCAACAGGTGATAAGCTAATTCGTGCAGGAGCACCAAAAGACTGGATGGTTTCTGATAAAAGTGGAACTGGTTCTTACGGAACAAGAAATGATATTGCAATAGTAATACCACCAAATAAAAAGCCTATATTTATTGCAATATTATCAAGTAAAAACGATAAAGATGCTAAATATGATGACAAAACAATTTCTGAGGCTTCTAAAATTGTATTTGATTATTTTATTAACACCAGGAAATAG", "partial": "0", "query_start": 39647, "query_end": 39670, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2555|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 39587, "orf_end": 39811, "orf_from": "NODE_19_length_86672_cov_43.8582_38 ", "model_name": "ACI-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2874", "ARO_accession": "3004359", "ARO_name": "ACI-1", "ARO_category": {"41530": {"category_aro_accession": "3004358", "category_aro_cvterm_id": "41530", "category_aro_name": "ACI beta-lactamase", "category_aro_description": "A family of class A beta-lactamase enzymes described in the gram-negative cocci Acidaminococcus fermentans.", "category_aro_class_name": "AMR Gene Family"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "36989": {"category_aro_accession": "3000645", "category_aro_cvterm_id": "36989", "category_aro_name": "cefotaxime", "category_aro_description": "Cefotaxime is a semisynthetic cephalosporin taken parenterally. It is resistant to most beta-lactamases and active against Gram-negative rods and cocci due to its aminothiazoyl and methoximino functional groups.", "category_aro_class_name": "Antibiotic"}, "40523": {"category_aro_accession": "3003832", "category_aro_cvterm_id": "40523", "category_aro_name": "ticarcillin", "category_aro_description": "Ticarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.58332, "max_identities": 8, "bit_score": 21.1718, "cvterm_id": "41532", "query": "PPPTKPVNPGIQSATPDRNDRGD", "match": "PP  KP+   I S   ++N + D", "sequence_from_db": "PPNRKPIVMAIMSRRTEKNAKSD", "sequence_from_broadstreet": "MKKFCFLFLIICGLMVFCLQDCQARQKLNLADLENKYNAVIGVYAVDMENGKKICYKPDTRFSYCSTHKVFTAAELLRQKNTSDLNEIRKFSAEDILSYAPITKDHVADGMTLAEICSASLRWSDNTAANLILQEIGGVENFKVALKNIGDKTTKPARNEPELNLFNPKDNRDTSTPRQMVKNLQVYIFGDILSDDKKKLLIDWMSDNSITDTLIKAETPQGWKVIDKSGSGDYGARNDIAVIYPPNRKPIVMAIMSRRTEKNAKSDDAMIAEAAKRIFDNLVF", "dna_sequence_from_broadstreet": "ATGAAGAAATTTTGTTTTTTGTTTTTGATAATCTGTGGCTTGATGGTTTTCTGCCTTCAGGATTGTCAAGCGCGGCAGAAATTAAATCTTGCTGATCTGGAAAATAAATATAACGCCGTGATTGGTGTTTACGCCGTTGACATGGAGAATGGAAAAAAAATTTGCTACAAACCTGATACGCGTTTTTCCTACTGCTCGACACACAAAGTTTTTACGGCTGCAGAATTGCTAAGACAAAAAAATACCTCCGATTTGAATGAAATTCGTAAGTTTTCGGCGGAAGATATTTTGTCCTACGCGCCAATCACCAAAGACCATGTTGCTGATGGCATGACGCTGGCGGAAATTTGTTCGGCATCGCTCAGGTGGAGTGACAACACGGCGGCAAATTTAATTTTGCAGGAGATCGGCGGCGTGGAAAATTTCAAGGTGGCACTTAAAAATATTGGCGACAAAACTACCAAACCTGCGCGAAATGAACCTGAACTTAATCTTTTCAATCCAAAAGATAATCGTGATACTAGCACGCCGAGACAGATGGTAAAAAATTTGCAAGTCTATATATTCGGCGATATTTTGAGCGACGACAAGAAAAAACTGCTGATTGATTGGATGAGCGACAATTCCATAACCGACACGCTTATCAAGGCAGAAACTCCGCAAGGTTGGAAAGTTATCGACAAGAGCGGTTCAGGCGATTATGGGGCGCGGAATGATATTGCCGTGATTTATCCGCCCAATCGCAAACCCATTGTCATGGCGATAATGTCGCGCCGCACGGAAAAAAATGCAAAATCTGACGACGCTATGATTGCGGAGGCGGCAAAACGAATTTTTGATAATTTAGTATTTTAA", "partial": "0", "query_start": 39713, "query_end": 39781, "orf_dna_sequence": "ATGAATCACGGGCAACTATCAATGAAAAACGTTTTTCCTACGCTTGCCGTTTTGTTTGCGATCTTCAGCCTGACCGGCTGCGGTCTGAAAGGGCCTCTCTATTTCCCACCGGCGGACAAAACCGCGCCGCCGCCGACCAAACCGGTTAACCCTGGCATTCAGAGCGCAACGCCGGATCGTAACGATCGTGGCGATACCGGTGGTCCGAGCCAGGTCAATTACTAA", "orf_prot_sequence": "MNHGQLSMKNVFPTLAVLFAIFSLTGCGLKGPLYFPPADKTAPPPTKPVNPGIQSATPDRNDRGDTGGPSQVNY", "perc_identity": 34.78}}, "NODE_21_length_66123_cov_41.3566_52 # 60858 # 62090 # 1 # ID=21_52;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.603": {"gnl|BL_ORD_ID|2494|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 60858, "orf_end": 62090, "orf_from": "NODE_21_length_66123_cov_41.3566_52", "model_name": "Escherichia coli mdfA", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "37", "pass_evalue": "n/a", "pass_bitscore": "700", "ARO_accession": "3001328", "ARO_name": "Escherichia coli mdfA", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "40514": {"category_aro_accession": "3003823", "category_aro_cvterm_id": "40514", "category_aro_name": "benzalkonium chloride", "category_aro_description": "Benzalkonium chloride is a type of cationic surfactant. It is an organic salt called a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent.", "category_aro_class_name": "Drug Class"}, "40518": {"category_aro_accession": "3003827", "category_aro_cvterm_id": "40518", "category_aro_name": "rhodamine", "category_aro_description": "Rhodamine is a flurone dye that is often used as a tracer due to determine the rate and direction of flow and transport. It permeates the cell membrane of gram negative organisms E. coli and P. aeruginosa.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 706.057, "max_identities": 351, "cvterm_id": "35914", "query": "MQNYSLSGRRLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVQEFQVGNEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFIVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEMMFVLFAVLAAISFFGLQRAMPETATRLGEKLSVKELGRDYRLVLKNLRFVAGALATGFVSLPLLAWIAQSPVIIISGEQATSYEYGMLQVPIFGALIAGNLVLARLTARRTVRSLIIMGGWPIMFGLILSAAATVVSSHAYLWMTAGLSFYAFGIGLANAGLVRLTLFASEMSKGTVSAAMGMLQMLIFTVGIELSKHAYELGGNGLFSLFNLLGGVLWLGLMIYFLKDKSVGNSQQG", "match": "MQN   SG RLGRQALLFPLCLVLYEFSTYIGNDM QPGML  V+++Q G EWVPTSM AYLAGGMF+QWLLGPLSDRIGRRPVML GVVWFIVTCLA LLAQ IEQFTLLRFL GISLCFIGAVGY AIQESFEEAVCIKITALMANVALIAPLLGPLVGA+W+HVLPWE MFVLFA LAAISFFGLQRAMPETATR+GEKLS+KELGRDY+LVLKN RFVAGALA GF+SLPLLAWIAQSP+III+GEQ +SYEYG+LQVPIFGALIAGNL+LARLT+RRTVRSLIIMGGWPIM GL+++AAATV+SSHAYLWMTAGLS YAFGIGLANAGLVRLTLFAS MSKGTVSAAMGMLQMLIFTVGIE+SKHA+  GGNGLF+LFNL+ G+L L LM+ FLKDK +GNS +G", "sequence_from_db": "MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMRQPGMLENVEQYQAGIEWVPTSMNAYLAGGMFIQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLHGISLCFIGAVGYDAIQESFEEAVCIKITALMANVALIAPLLGPLVGASWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFLSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASVMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILLLSLMVIFLKDKQMGNSHEG", "sequence_from_broadstreet": "MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMRQPGMLENVEQYQAGIEWVPTSMNAYLAGGMFIQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLHGISLCFIGAVGYDAIQESFEEAVCIKITALMANVALIAPLLGPLVGASWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFLSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASVMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILLLSLMVIFLKDKQMGNSHEG", "dna_sequence_from_broadstreet": "ATGCAAAATAAATTAGCTTCCGGTGCCAGGCTTGGACGTCAGGCGTTACTTTTTCCTCTCTGTCTGGTGCTTTACGAATTTTCAACCTATATCGGCAACGATATGAGGCAACCCGGTATGTTGGAAAATGTGGAACAATATCAGGCGGGCATTGAGTGGGTTCCTACTTCGATGAACGCGTATCTGGCGGGCGGGATGTTTATACAATGGCTGCTGGGGCCGCTGTCGGATCGTATTGGTCGTCGTCCGGTGATGCTGGCGGGAGTGGTGTGGTTTATCGTCACATGTCTGGCAATATTGCTGGCGCAAAACATTGAACAATTCACCCTGTTGCGCTTCTTGCACGGCATAAGCCTCTGTTTCATTGGCGCTGTGGGATACGACGCAATTCAGGAATCCTTCGAAGAGGCGGTTTGTATCAAGATCACCGCGCTGATGGCGAACGTGGCGCTGATTGCTCCGCTACTTGGTCCGCTGGTGGGCGCGTCGTGGATCCATGTGCTGCCCTGGGAGGGGATGTTTGTTTTGTTTGCCGCATTGGCAGCGATCTCCTTTTTCGGTCTGCAACGGGCCATGCCTGAAACCGCCACGCGTATAGGCGAGAAACTGTCACTGAAAGAACTCGGTCGTGACTATAAGCTGGTGCTGAAGAACGGCCGCTTTGTGGCGGGGGCGCTGGCGCTGGGATTCCTTAGTCTGCCGTTGCTGGCGTGGATCGCCCAGTCGCCGATTATCATCATTACCGGCGAGCAGTTGAGCAGCTATGAATATGGCTTGCTGCAAGTGCCTATTTTCGGGGCGTTAATTGCGGGTAACTTGCTGTTAGCGCGTCTGACCTCGCGCCGCACCGTACGTTCGCTGATTATTATGGGCGGCTGGCCGATTATGATTGGTCTATTGGTCGCTGCTGCGGCAACGGTTATCTCATCGCACGCGTATTTATGGATGACTGCCGGGTTAAGTATTTATGCTTTCGGTATTGGTCTGGCGAATGCGGGACTGGTGCGATTAACCCTGTTTGCCAGCGTTATGAGTAAAGGTACGGTTTCTGCCGCGATGGGAATGCTGCAAATGCTGATCTTTACCGTTGGTATTGAAATCAGCAAACATGCCTGGCTGAACGGGGGCAACGGACTGTTTAATCTCTTCAACCTTGTCAACGGAATTTTGTTGCTGTCGCTGATGGTTATCTTTTTAAAAGATAAACAGATGGGAAATTCTCACGAAGGGTAA", "partial": "0", "query_start": 60858, "query_end": 62087, "orf_dna_sequence": "ATGCAAAATTATTCGCTTTCAGGCCGCCGCCTCGGAAGGCAGGCGCTGTTGTTCCCGTTATGTCTGGTGCTGTACGAGTTTTCCACTTATATCGGCAACGATATGATTCAGCCGGGCATGTTAGCCGTGGTGCAGGAATTTCAGGTGGGCAACGAATGGGTACCTACTTCAATGACTGCCTATCTGGCAGGCGGCATGTTTTTACAGTGGCTGCTGGGGCCGCTGTCGGATCGTATTGGCCGCCGTCCGGTGATGTTGACCGGCGTAGTATGGTTTATCGTCACCTGCCTGGCGACGCTGCTGGCGCAGACCATTGAGCAGTTTACCCTGCTGCGCTTCCTGCAGGGGATCAGCCTGTGCTTTATCGGCGCGGTGGGCTATGCGGCGATACAGGAGTCCTTTGAGGAGGCGGTGTGTATCAAAATCACCGCCCTGATGGCTAACGTGGCGCTGATTGCCCCGCTGCTGGGGCCGCTGGTGGGCGCCGCCTGGGTGCATGTCCTGCCGTGGGAGATGATGTTTGTCCTGTTCGCCGTGCTGGCGGCCATCTCGTTCTTCGGCCTGCAGCGGGCGATGCCGGAGACCGCGACGCGGCTGGGCGAAAAGCTGTCGGTGAAAGAGCTGGGCCGCGACTATCGGCTGGTGCTGAAGAACCTGCGCTTCGTCGCCGGCGCGCTGGCCACTGGCTTTGTCAGCCTGCCGCTGCTGGCGTGGATTGCCCAGTCGCCGGTGATTATTATCAGCGGCGAACAGGCCACCAGCTATGAGTACGGCATGCTGCAGGTGCCGATTTTCGGGGCGCTGATTGCCGGCAACCTGGTGCTGGCGCGCCTGACTGCGCGTCGGACCGTGCGCTCGCTGATTATCATGGGCGGTTGGCCGATCATGTTTGGCCTGATCCTCTCTGCGGCGGCGACCGTGGTCTCTTCCCACGCTTATCTGTGGATGACGGCCGGTCTGAGCTTCTACGCCTTCGGGATTGGCCTCGCGAACGCCGGCCTGGTGCGTTTAACCCTGTTCGCCAGCGAGATGAGTAAAGGCACGGTCTCGGCGGCGATGGGAATGCTGCAGATGCTGATCTTCACCGTCGGCATCGAGCTCAGCAAACATGCTTACGAGCTGGGCGGCAACGGGCTGTTCAGCCTGTTTAACCTGCTGGGTGGGGTACTATGGCTGGGGCTGATGATTTACTTTCTGAAAGATAAAAGCGTCGGCAATTCGCAGCAGGGGTAG", "orf_prot_sequence": "MQNYSLSGRRLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVQEFQVGNEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFIVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEMMFVLFAVLAAISFFGLQRAMPETATRLGEKLSVKELGRDYRLVLKNLRFVAGALATGFVSLPLLAWIAQSPVIIISGEQATSYEYGMLQVPIFGALIAGNLVLARLTARRTVRSLIIMGGWPIMFGLILSAAATVVSSHAYLWMTAGLSFYAFGIGLANAGLVRLTLFASEMSKGTVSAAMGMLQMLIFTVGIELSKHAYELGGNGLFSLFNLLGGVLWLGLMIYFLKDKSVGNSQQG", "perc_identity": 85.61}}, "NODE_27_length_37761_cov_37.6839_21 # 25311 # 25673 # 1 # ID=27_21;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.471": {"gnl|BL_ORD_ID|2771|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 25311, "orf_end": 25673, "orf_from": "NODE_27_length_37761_cov_37.6839_21", "model_name": "Klebsiella pneumoniae KpnE", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "3283", "pass_evalue": "n/a", "pass_bitscore": "150", "ARO_accession": "3004580", "ARO_name": "Klebsiella pneumoniae KpnE", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.37865e-78, "bit_score": 223.402, "max_identities": 119, "cvterm_id": "42598", "query": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSKQEVAHAAV", "match": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASS+QEVAHAAV", "sequence_from_db": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSQQEVAHAAV", "sequence_from_broadstreet": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSQQEVAHAAV", "dna_sequence_from_broadstreet": "ATGTTTTATTGGATTTTATTAGCTTTAGCAATTATTGCTGAAATTACCGGCACCTTGTCTATGAAATGGGCAAGCGTGAGCGGCGGGCACACCGGCTTTATTTTAATGCTGGCCATGATTGCCCTGTCATATATTTTTCTTGCCTTTGCGGTTAAAAAGATTGCCCTCGGTGTGGCCTATGCGTTGTGGGAAGGGATCGGTATTTTACTGATTACCCTGTTCAGCGTGCTGCTGTTTGATGAGAGTCTGTCCCTGCTGAAAATAGCCGGCTTGACCACCCTGGTGATAGGGATCGTCTTAATTAAGTCCGGCACCCAGAAAAAAGCGTCTTCACAGCAGGAGGTGGCCCATGCAGCAGTTTGA", "partial": "0", "query_start": 25311, "query_end": 25670, "orf_dna_sequence": "ATGTTTTATTGGATTTTATTAGCTTTAGCAATTATTGCTGAAATTACCGGCACCTTGTCTATGAAATGGGCAAGCGTGAGCGGCGGGCACACCGGCTTTATTTTAATGCTGGCCATGATTGCCCTGTCATATATTTTTCTTGCCTTTGCGGTTAAAAAGATTGCCCTCGGTGTGGCCTATGCGTTGTGGGAAGGGATCGGTATTTTACTGATTACCCTGTTCAGCGTGCTGCTGTTTGATGAGAGTCTGTCCCTGCTGAAAATAGCCGGCTTGACCACCCTGGTGATAGGGATCGTCTTAATTAAGTCCGGCACCCAGAAAAAAGCGTCTTCCAAGCAGGAGGTGGCCCATGCAGCAGTTTGA", "orf_prot_sequence": "MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSKQEVAHAAV", "perc_identity": 99.17}}, "NODE_27_length_37761_cov_37.6839_22 # 25660 # 25989 # 1 # ID=27_22;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.588": {"gnl|BL_ORD_ID|2774|hsp_num:0": {"type_match": "Perfect", "model_id": "3286", "orf_strand": "+", "orf_start": 25660, "orf_end": 25989, "orf_from": "NODE_27_length_37761_cov_37.6839_22", "model_name": "Klebsiella pneumoniae KpnF", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "150", "ARO_accession": "3004583", "ARO_name": "Klebsiella pneumoniae KpnF", "ARO_category": {"36003": {"category_aro_accession": "0010002", "category_aro_cvterm_id": "36003", "category_aro_name": "major facilitator superfamily (MFS) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35958": {"category_aro_accession": "0000040", "category_aro_cvterm_id": "35958", "category_aro_name": "streptomycin", "category_aro_description": "Streptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36966": {"category_aro_accession": "3000622", "category_aro_cvterm_id": "36966", "category_aro_name": "colistin A", "category_aro_description": "Colistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "36968": {"category_aro_accession": "3000624", "category_aro_cvterm_id": "36968", "category_aro_name": "colistin B", "category_aro_description": "Colistin B, or polymyxin E2, has a 6-heptanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36192": {"category_aro_accession": "3000053", "category_aro_cvterm_id": "36192", "category_aro_name": "peptide antibiotic", "category_aro_description": "Peptide antibiotics have a wide range of antibacterial mechanisms, depending on the amino acids that make up the antibiotic, although most act to disrupt the cell membrane in some manner. Subclasses of peptide antibiotics can include additional sidechains of other types, such as lipids in the case of the lipopeptide antibiotics.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.08351e-72, "bit_score": 206.453, "max_identities": 109, "cvterm_id": "42598", "query": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "match": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "sequence_from_db": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "sequence_from_broadstreet": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "dna_sequence_from_broadstreet": "ATGCAGCAGTTTGAGTGGATCCACGCCGCCTGGCTGGCAATCGCCATTGTGCTGGAAATTATTGCCAACGTCTTTTTGAAGTTTTCCGACGGCTTCCGCCGCAAGATCTACGGCATCCTGTCCCTGGCGGCAGTATTGGGCGCGTTCAGCGCCCTGTCGCAGGCGGTTAAAGGGATCGATCTCTCGGTCGCCTATGCGCTGTGGGGCGGCTTCGGTATCGCGGCGACCATCGCCGCCGGCTGGGTGCTGTTTGGTCAGCGTCTGAATAACAAAGGCTGGGCGGGGGTTATCCTGCTGGTAGCCGGCATGGTGTTAATTAAACTCGCCTGA", "partial": "0", "query_start": 25660, "query_end": 25986, "orf_dna_sequence": "ATGCAGCAGTTTGAGTGGATCCACGCCGCCTGGCTGGCAATCGCCATTGTGCTGGAAATTATTGCCAACGTCTTTTTGAAGTTTTCCGACGGCTTCCGCCGCAAGATCTACGGCATCCTGTCCCTGGCGGCAGTATTGGGCGCGTTCAGCGCCCTGTCGCAGGCGGTTAAAGGGATCGATCTCTCGGTCGCCTATGCGCTGTGGGGCGGCTTCGGTATCGCGGCGACCATCGCCGCCGGCTGGGTGCTGTTTGGTCAGCGTCTGAATAACAAAGGCTGGGCGGGGGTTATCCTGCTGGTAGCCGGCATGGTGTTAATTAAACTCGCCTGA", "orf_prot_sequence": "MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA", "perc_identity": 100.0}}, "NODE_39_length_11164_cov_23.0187_6 # 4569 # 5429 # 1 # ID=39_6;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.598": {"gnl|BL_ORD_ID|2170|hsp_num:0": {"type_match": "Perfect", "model_id": "3322", "orf_strand": "+", "orf_start": 4569, "orf_end": 5429, "orf_from": "NODE_39_length_11164_cov_23.0187_6", "model_name": "AAC(3)-IId", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "570", "ARO_accession": "3004623", "ARO_name": "AAC(3)-IId", "ARO_category": {"36461": {"category_aro_accession": "3000322", "category_aro_cvterm_id": "36461", "category_aro_name": "AAC(3)", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 3.", "category_aro_class_name": "AMR Gene Family"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 586.645, "max_identities": 286, "cvterm_id": "35914", "query": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "match": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "sequence_from_db": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "sequence_from_broadstreet": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "dna_sequence_from_broadstreet": "ATGCATACGCGGAAGGCAATAACGGAGGCGCTTCAAAAACTCGGAGTCCAAACCGGTGACCTCTTGATGGTGCATGCCTCACTTAAAGCGATTGGTCCGGTCGAAGGAGGAGCGGAGACGGTCGTTGCCGCGTTACGCTCCGCGGTTGGGCCGACTGGCACTGTGATGGGATACGCGTCGTGGGACCGATCACCCTACGAGGAGACTCTGAATGGCGCTCGGCTGGATGACGAAGCCCGCCGTACCTGGCTGCCGTTCGATCCCGCAACAGCCGGGACTTACCGTGGGTTCGGCCTGCTGAATCAATTTCTGGTTCAAGCCCCCGGCGCGCGGCGCAGCGCGCACCCCGATGCATCGATGGTCGCGGTTGGTCCGCTGGCTGAAACGCTGACGGAGCCTCACGAACTCGGTCACGCCTTGGGGGAAGGATCGCCCGTCGAGCGGTTCGTTCGCCTTGGCGGGAAGGCCCTGCTGTTGGGTGCGCCGCTAAACTCCGTTACCGCATTGCACTACGCCGAGGCGGTTGCCGATATCCCCAACAAACGGTGGGTGACGTATGAGATGCCGATGCTTGGAAGAGACGGTGAAGTCGCCTGGAAAACGGCATCGGATTACGATTCAAACGGCATTCTCGATTGCTTTGCTATCGAAGGAAAGCCGGATGCGGTTGAAACTATAGCAAATGCTTACGTGAAGCTCGGTCGCCATCGAGAAGGTGTCGTGGGCTTTGCTCAGTGCTACCTGTTCGACGCGCAGGACATCGTGACGTTCGGCGTCACCTATCTTGAGAAGCATTTCGGAACCACTCCGATCGTGCCTCCGCACGAGGCCGTCGAGCGCTCTTGCGAGCCTTCCGGTTAG", "partial": "0", "query_start": 4569, "query_end": 5426, "orf_dna_sequence": "ATGCATACGCGGAAGGCAATAACGGAGGCGCTTCAAAAACTCGGAGTCCAAACCGGTGACCTCTTGATGGTGCATGCCTCACTTAAAGCGATTGGTCCGGTCGAAGGAGGAGCGGAGACGGTCGTTGCCGCGTTACGCTCCGCGGTTGGGCCGACTGGCACTGTGATGGGATACGCGTCGTGGGACCGATCACCCTACGAGGAGACTCTGAATGGCGCTCGGCTGGATGACGAAGCCCGCCGTACCTGGCTGCCGTTCGATCCCGCAACAGCCGGGACTTACCGTGGGTTCGGCCTGCTGAATCAATTTCTGGTTCAAGCCCCCGGCGCGCGGCGCAGCGCGCACCCCGATGCATCGATGGTCGCGGTTGGTCCGCTGGCTGAAACGCTGACGGAGCCTCACGAACTCGGTCACGCCTTGGGGGAAGGATCGCCCGTCGAGCGGTTCGTTCGCCTTGGCGGGAAGGCCCTGCTGTTGGGTGCGCCGCTAAACTCCGTTACCGCATTGCACTACGCCGAGGCGGTTGCCGATATCCCCAACAAACGGTGGGTGACGTATGAGATGCCGATGCTTGGAAGAGACGGTGAAGTCGCCTGGAAAACGGCATCGGATTACGATTCAAACGGCATTCTCGATTGCTTTGCTATCGAAGGAAAGCCGGATGCGGTTGAAACTATAGCAAATGCTTACGTGAAGCTCGGTCGCCATCGAGAAGGTGTCGTGGGCTTTGCTCAGTGCTACCTGTTCGACGCGCAGGACATCGTGACGTTCGGCGTCACCTATCTTGAGAAGCATTTCGGAACCACTCCGATCGTGCCTCCGCACGAGGCCGTCGAGCGCTCTTGCGAGCCTTCAGGTTAG", "orf_prot_sequence": "MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAALRSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFLVQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPLNSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDAVETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERSCEPSG", "perc_identity": 100.0}}, "NODE_40_length_7360_cov_24.8738_6 # 6358 # 7203 # -1 # ID=40_6;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.410": {"gnl|BL_ORD_ID|1448|hsp_num:0": {"type_match": "Perfect", "model_id": "1540", "orf_strand": "-", "orf_start": 6358, "orf_end": 7203, "orf_from": "NODE_40_length_7360_cov_24.8738_6", "model_name": "rmtC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3000861", "ARO_name": "rmtC", "ARO_category": {"41435": {"category_aro_accession": "3004271", "category_aro_cvterm_id": "41435", "category_aro_name": "16S rRNA methyltransferase (G1405)", "category_aro_description": "Methyltransferases that methylate the G1405 position of 16S rRNA, which is part of an aminoglycoside binding site.", "category_aro_class_name": "AMR Gene Family"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36997": {"category_aro_accession": "3000653", "category_aro_cvterm_id": "36997", "category_aro_name": "G418", "category_aro_description": "A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3').", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 578.941, "max_identities": 281, "cvterm_id": "36752", "query": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "match": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "sequence_from_db": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "sequence_from_broadstreet": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "dna_sequence_from_broadstreet": "ATGAAAACCAACGATAATTATATCGAAGAAGTAACAGCCAAAGTACTCACAAGTGGTAAATACTCCACACTTTATCCACCAACTGTACGACGTGTAACTGAGAGGCTTTTCGATCGATACCCTCCCAAGCAGCTAGAGAAGGAGGTTCGCAAGAAATTGCATCAAGCATATGGTGCTTATATTGGTGGGATCGATGGGAAAAGGTTGGAGAAGAAGATTGAGAAGATAATTCATGAGATACCAAATCCAACTACGGATGAAGCAACTCGTACGGAGTGGGAAAAAGAGATCTGCCTGAAAATATTGAACTTGCACACTTCAACAAATGAGCGAACGGTGGCTTACGATGAGCTTTACCAAAAGATCTTTGAGGTAACAGGGGTTCCAACAAGTATCACCGATGCAGGTTGCGCTTTGAATCCATTTTCTTTTCCATTCTTTACGGAGGCTGGCATGCTTGGGCAATACATAGGTTTCGATCTTGATAAAGGTATGATCGAAGCGATCGAACACTCGTTGAGAACGCTTAACGCCCCAGAGGGTATTGTTGTCAAACAGGGAGATATATTATCCGATCCGTCAGGCGAGAGTGATCTTCTACTTATGTTCAAGCTATATACTCTACTCGATCGGCAGGAAGAGGCCTCTGGTTTGAAAATTCTTCAAGAGTGGAAATACAAAAATGCTGTGATCTCTTTTCCTATTAAAACTATAAGTGGGAGAGATGTTGGGATGGAAGAGAATTACACTGTTAAGTTCGAGAATGATCTTGTTGGGTCAGATCTGAGAATCATGCAAAAATTGAAATTAGGAAACGAGATGTATTTTATCGTATCGAGATTGTAA", "partial": "0", "query_start": 6358, "query_end": 7200, "orf_dna_sequence": "ATGAAAACCAACGATAATTATATCGAAGAAGTAACAGCCAAAGTACTCACAAGTGGTAAATACTCCACACTTTATCCACCAACTGTACGACGTGTAACTGAGAGGCTTTTCGATCGATACCCTCCCAAGCAGCTAGAGAAGGAGGTTCGCAAGAAATTGCATCAAGCATATGGTGCTTATATTGGTGGGATCGATGGGAAAAGGTTGGAGAAGAAGATTGAGAAGATAATTCATGAGATACCAAATCCAACTACGGATGAAGCAACTCGTACGGAGTGGGAAAAAGAGATCTGCCTGAAAATATTGAACTTGCACACTTCAACAAATGAGCGAACGGTGGCTTACGATGAGCTTTACCAAAAGATCTTTGAGGTAACAGGGGTTCCAACAAGTATCACCGATGCAGGTTGCGCTTTGAATCCATTTTCTTTTCCATTCTTTACGGAGGCTGGCATGCTTGGGCAATACATAGGTTTCGATCTTGATAAAGGTATGATCGAAGCGATCGAACACTCGTTGAGAACGCTTAACGCCCCAGAGGGTATTGTTGTCAAACAGGGAGATATATTATCCGATCCGTCAGGCGAGAGTGATCTTCTACTTATGTTCAAGCTATATACTCTACTCGATCGGCAGGAAGAGGCCTCTGGTTTGAAAATTCTTCAAGAGTGGAAATACAAAAATGCTGTGATCTCTTTTCCTATTAAAACTATAAGTGGGAGAGATGTTGGGATGGAAGAGAATTACACTGTTAAGTTCGAGAATGATCTTGTTGGGTCAGATCTGAGAATCATGCAAAAATTGAAATTAGGAAACGAGATGTATTTTATCGTATCGAGATTGTAA", "orf_prot_sequence": "MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL", "perc_identity": 100.0}}, "NODE_44_length_4295_cov_23.2123_1 # 301 # 1113 # 1 # ID=44_1;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.615": {"gnl|BL_ORD_ID|731|hsp_num:0": {"type_match": "Perfect", "model_id": "783", "orf_strand": "+", "orf_start": 301, "orf_end": 1113, "orf_from": "NODE_44_length_4295_cov_23.2123_1", "model_name": "NDM-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3000589", "ARO_name": "NDM-1", "ARO_category": {"35996": {"category_aro_accession": "0000079", "category_aro_cvterm_id": "35996", "category_aro_name": "clavulanic acid", "category_aro_description": "Clavulanic acid is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins.", "category_aro_class_name": "Adjuvant"}, "36196": {"category_aro_accession": "3000057", "category_aro_cvterm_id": "36196", "category_aro_name": "NDM beta-lactamase", "category_aro_description": "NDM beta-lactamases or New Delhi metallo-beta-lactamases are class B beta-lactamases that confer resistance to a broad range of antibiotics including carbapenems, cephalosporins and penicillins.", "category_aro_class_name": "AMR Gene Family"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35987": {"category_aro_accession": "0000070", "category_aro_cvterm_id": "35987", "category_aro_name": "ertapenem", "category_aro_description": "Ertapenem is a carbapenem antibiotic and is highly resistant to beta-lactamases like other carbapenems. It inhibits bacterial cell wall synthesis.", "category_aro_class_name": "Antibiotic"}, "35990": {"category_aro_accession": "0000073", "category_aro_cvterm_id": "35990", "category_aro_name": "meropenem", "category_aro_description": "Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.", "category_aro_class_name": "Antibiotic"}, "36309": {"category_aro_accession": "3000170", "category_aro_cvterm_id": "36309", "category_aro_name": "imipenem", "category_aro_description": "Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.", "category_aro_class_name": "Antibiotic"}, "40924": {"category_aro_accession": "3003997", "category_aro_cvterm_id": "40924", "category_aro_name": "amoxicillin-clavulanic acid", "category_aro_description": "An antibiotic cocktail containing the beta-lactam antibiotic Amoxicillin and the beta-lactamase inhibitor Clavulanic Acid (potassium clavulanate).", "category_aro_class_name": "Antibiotic"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 555.829, "max_identities": 270, "cvterm_id": "35915", "query": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "match": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "sequence_from_db": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "sequence_from_broadstreet": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "dna_sequence_from_broadstreet": "ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA", "partial": "0", "query_start": 301, "query_end": 1110, "orf_dna_sequence": "ATGGAATTGCCCAATATTATGCACCCGGTCGCGAAGCTGAGCACCGCATTAGCCGCTGCATTGATGCTGAGCGGGTGCATGCCCGGTGAAATCCGCCCGACGATTGGCCAGCAAATGGAAACTGGCGACCAACGGTTTGGCGATCTGGTTTTCCGCCAGCTCGCACCGAATGTCTGGCAGCACACTTCCTATCTCGACATGCCGGGTTTCGGGGCAGTCGCTTCCAACGGTTTGATCGTCAGGGATGGCGGCCGCGTGCTGGTGGTCGATACCGCCTGGACCGATGACCAGACCGCCCAGATCCTCAACTGGATCAAGCAGGAGATCAACCTGCCGGTCGCGCTGGCGGTGGTGACTCACGCGCATCAGGACAAGATGGGCGGTATGGACGCGCTGCATGCGGCGGGGATTGCGACTTATGCCAATGCGTTGTCGAACCAGCTTGCCCCGCAAGAGGGGATGGTTGCGGCGCAACACAGCCTGACTTTCGCCGCCAATGGCTGGGTCGAACCAGCAACCGCGCCCAACTTTGGCCCGCTCAAGGTATTTTACCCCGGCCCCGGCCACACCAGTGACAATATCACCGTTGGGATCGACGGCACCGACATCGCTTTTGGTGGCTGCCTGATCAAGGACAGCAAGGCCAAGTCGCTCGGCAATCTCGGTGATGCCGACACTGAGCACTACGCCGCGTCAGCGCGCGCGTTTGGTGCGGCGTTCCCCAAGGCCAGCATGATCGTGATGAGCCATTCCGCCCCCGATAGCCGCGCCGCAATCACTCATACGGCCCGCATGGCCGACAAGCTGCGCTGA", "orf_prot_sequence": "MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR", "perc_identity": 100.0}}, "NODE_44_length_4295_cov_23.2123_2 # 1222 # 1482 # 1 # ID=44_2;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.621": {"gnl|BL_ORD_ID|2418|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "determinant of bleomycin resistance", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "200", "model_id": "255", "ARO_accession": "3001205", "ARO_name": "BRP(MBL)", "ARO_category": {"41420": {"category_aro_accession": "3004256", "category_aro_cvterm_id": "41420", "category_aro_name": "Bleomycin resistant protein", "category_aro_description": "Bleomycin resistant proteins (BRP) confer resistance to bleomycin and to bleomycin-like molecules.", "category_aro_class_name": "AMR Gene Family"}, "37034": {"category_aro_accession": "3000690", "category_aro_cvterm_id": "37034", "category_aro_name": "bleomycinic acid", "category_aro_description": "Bleomycinic acid is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids.", "category_aro_class_name": "Antibiotic"}, "37035": {"category_aro_accession": "3000691", "category_aro_cvterm_id": "37035", "category_aro_name": "bleomycin A2", "category_aro_description": "Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids.", "category_aro_class_name": "Antibiotic"}, "37036": {"category_aro_accession": "3000692", "category_aro_cvterm_id": "37036", "category_aro_name": "bleomycin B2", "category_aro_description": "Bleomycin B2 is a glycopeptide antibiotic produced by Streptomyces verticillus taken as a mixture of bleomycins. It induces stand breaks in bacterial nucleic acids.", "category_aro_class_name": "Antibiotic"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.47103e-61, "max_identities": 86, "bit_score": 177.563, "cvterm_id": "35507", "query": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "match": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "sequence_from_db": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "sequence_from_broadstreet": "MADHVTPNLPSRDFDVTEAFYAKLGFATSWKDRGWMILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "dna_sequence_from_broadstreet": "ATGGCTGACCACGTCACCCCCAATCTGCCATCGCGCGATTTCGATGTGACAGAGGCGTTTTATGCGAAGCTGGGCTTTGCGACGAGTTGGAAGGATCGCGGCTGGATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "partial": "0", "query_start": 1222, "query_end": 1479, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|263|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "smeD", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "284", "ARO_accession": "3003055", "ARO_name": "smeD", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.587866, "max_identities": 9, "bit_score": 25.0238, "cvterm_id": "37076", "query": "FPYPDLDPATSSFGCCLRLDDLDAMV", "match": "F    +DP T SFG  +++D+ D ++", "sequence_from_db": "FSEVSVDPTTGSFGLRVKVDNPDGLL", "sequence_from_broadstreet": "MLLSRIRPFALSLAIAATVAACGGQPQAPEQGPGDVTVVTLKSETVGLTRELPGRTNAFLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQLDDASYRAQANNARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATEKGDAPAKPAAAAQPAAPAGDAK", "dna_sequence_from_broadstreet": "ATGTTGCTGAGCCGAATCCGACCCTTTGCACTGTCGCTGGCAATCGCCGCGACCGTGGCTGCCTGCGGCGGCCAACCCCAGGCCCCCGAGCAGGGCCCGGGTGACGTCACCGTGGTCACGCTGAAGTCCGAGACCGTGGGCCTGACCCGCGAACTGCCGGGCCGTACCAATGCCTTCCTGGTCGCCGAAGTGCGCCCGCAGGTCAATGGCATCGTGGCCAAGCGCCTGTTTACCGAGGGCGGCATGGTCAAGGCCGGCGAGCCGCTGTACCAGCTCGACGATGCCAGCTACCGGGCCCAGGCCAACAACGCCCGCGCCCAGCTGGCCCGCGCCGAAGCCACCGCCAATGCCGCGCGCCTGAGTGCCAAGCGCATCACCGAGCTGGCCAAGGTCGATGCGGTCAGCCAGCAGGACCTGGAGAACGCCGTCGCCGCGCAGAAGCAGGCCGAGGCCGACGTCGGTGCCGCCAAGGCCTCGCTGGATGCGGCCAACGTCACCCTGGGCTACGCCCGCATCACCGCGCCGATCAGCGGCCGCATCGGCAAGTCCAGCGTCACCCAGGGTGCGCTGGTCAGCGCCGGCCAGGCCAACGCACTGGCCACCGTGCAGCAGCTGGACCCGATCTATGTCGACCTGACCCAGTCCTCGGCCGAGCTGCTGCAGCTGCGCCGCGAACTGGCCGCCGGCCGCCTGCAGGACAACCAGACCCTGCCGGTCAGCATCCTGATGGAAGACGGCAGCACCTTCGAGCACAAGGGCACTCTGGAGTTCTCCGAAGTCAGCGTTGATCCGACCACCGGCAGCTTCGGCCTGCGCGTGAAGGTGGACAACCCGGACGGCCTGCTGATGCCGGGCATGTACGTGCGTGCGGTGATCGGCGGCGGCGTGCGCAGCGACGCGGTGCTGGTGCCGATGCAGGGCATCGCGCGCGATCCGAAGGGCGACACCACCGCGATGGTGGTCGGCAAGGACAACAAGGTCGAAGTGCGCCCGGTCAAGGTCAGCCGCACGGTCGGCGACAAGTGGCTGGTCGAGGACGGCCTGAAGGCCGGTGACAAGGTCATCGTCGAAGGCCTGCAGAAGATCGGCCCCGGCATGCCGGTCAAGGCCACCGAGAAGGGCGACGCACCGGCCAAGCCGGCGGCAGCCGCCCAGCCTGCCGCCCCGGCCGGCGACGCGAAGTAA", "partial": "0", "query_start": 1258, "query_end": 1335, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 34.62}, "gnl|BL_ORD_ID|2150|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "OXA-440", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3510", "ARO_accession": "3003596", "ARO_name": "OXA-440", "ARO_category": {"36026": {"category_aro_accession": "3000017", "category_aro_cvterm_id": "36026", "category_aro_name": "OXA beta-lactamase", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.16443, "max_identities": 12, "bit_score": 22.3274, "cvterm_id": "35507", "query": "TGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQN", "match": "TGW   K PQ+   G   G++  PD  +V    N", "sequence_from_db": "TGWAMDKKPQV---GWLTGWVEQPDGKIVAFALN", "sequence_from_broadstreet": "MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDKKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII", "dna_sequence_from_broadstreet": "ATGAATAAATATTTTACTTGCTATGTGGTTGCTTCTCTTTTTCTTTCTGGTTGTACGGTTCAGCATAATTTAATAAATGAAACCCCGAGTCAGATTGTTCAAGGACATAATCAGGTGATTCATCAATACTTTGATGAAAAAAACACCTCAGGTGTGCTGGTTATTCAAACAGATAAAAAAATTAATCTATATGGTAATGCTCTAAGCCGCGCAAATACAGAATATGTGCCAGCCTCTACATTTAAAATGTTGAATGCCCTGATCGGATTGGAGAACCAGAAAACGGATATTAATGAAATATTTAAATGGAAGGGCGAGAAAAGGTCATTTACCGCTTGGGAAAAAGACATGACACTAGGAGAAGCCATGAAGCTTTCTGCAGTCCCAGTCTATCAGGAACTTGCGCGACGTATCGGTCTTGATCTCATGCAAAAAGAAGTAAAACGTATTGGTTTCGGTAATGCTGAAATTGGACAGCAGGTTGATAATTTCTGGTTGGTAGGACCATTAAAGGTTACGCCTATTCAAGAGGTAGAGTTTGTTTCCCAATTAGCACATACACAGCTTCCATTTAGTGAAAAAGTGCAGGCTAATGTAAAAAATATGCTTCTTTTAGAAGAGAGTAATGGCTACAAAATTTTTGGAAAGACTGGTTGGGCAATGGATAAAAAACCACAAGTGGGCTGGTTGACCGGCTGGGTTGAGCAGCCAGATGGAAAAATTGTCGCTTTTGCATTAAATATGGAAATGCGGTCAGAAATGCCGGCATCTATACGTAATGAATTATTGATGAAATCATTAAAACAGCTGAATATTATTTAA", "partial": "0", "query_start": 1372, "query_end": 1473, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 35.29}, "gnl|BL_ORD_ID|2048|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1222, "orf_end": 1482, "orf_from": "NODE_44_length_4295_cov_23.2123_2 ", "model_name": "TriA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "650", "model_id": "2192", "ARO_accession": "3003679", "ARO_name": "TriA", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.55444, "max_identities": 10, "bit_score": 21.557, "cvterm_id": "36804", "query": "LVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDP", "match": "+ +A GA      W R   P +  +GL +G   +P", "sequence_from_db": "MSDARGAFHSKGRWSRMALPAILCAGLLVGCGAEP", "sequence_from_broadstreet": "MSDARGAFHSKGRWSRMALPAILCAGLLVGCGAEPPAEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVLPWSALSKVGEQPAVWLLDQQGKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQPPQPTQSTASRDAVGGGQP", "dna_sequence_from_broadstreet": "ATGTCAGACGCCAGAGGCGCTTTTCATTCCAAAGGTCGCTGGTCGCGGATGGCGCTGCCCGCCATCCTGTGCGCCGGCCTGCTTGTCGGTTGCGGCGCCGAGCCGCCCGCCGAGGAACACGTCCGTGTGCTGGCGCAGACGGTGAAGATGGCCGAGTTCGCCTCGGCCACCTCGATCACCGGCGACATCCAGGCACGGGTACAGGCCGACCAGTCGTTCCGTGTCGGCGGCAAGATCGTCGAGCGCCTGGTCGATGTCGGCGACCACGTCGCGGCTGGCCAGGTGCTGGCGCGGCTCGACCCGCAGGACCAGCGCAGCAACGTGGAGAACGCCCAGGCGGCGGTCGCCGCGCAGCAGGCGCAGTCGAAGCTCGCCGACCTCAACTACCAGCGGCAGAAGGCGCTGCTGCCCAAGGGCTACACCAGCCAGAGCGAGTACGACCAGGCGCTGGCCTCGGTGCGCAGCGCGCAGAGTTCGCTGAAGGCCGCCCAGGCGCAGTTGGCCAACGCCCGCGACCTGCTTTCCTATACCGAGCTGCGTGCCTCCGACGCCGGGGTCATCACCGCCCGCCAGGCCGAGGTCGGCCAGGTGGTGCAGGCCACCGTGCCGATCTTCACCCTGGCCCGCGACGGCGAGCGCGACGCGGTGTTCAACGTCTACGAGTCGTTGTTCAGCCACGATGTCGACGGCCAGCGGATCACCGTCAGCCTGCTCGGCAAGCCGGAAGTCACCGCCAGCGGCAAGGTCCGCGAGATCACCCCCACGGTGGACGAGCGCAGCGGTACGCTGAAGGTCAAGGTCGGCCTCGACTCGGTGCCGGCGGAAATGAGCCTCGGCAGCGTGGTCAACGCCAGCGTCGCCGCGCCGGCCGAGCACAGCGTGGTGCTGCCCTGGTCGGCGCTGTCCAAGGTCGGCGAGCAGCCGGCGGTCTGGTTGCTCGACCAGCAAGGCAAGGCGCGTCTGCAACCGGTGCGGGTGGCACGCTACGCCAGCGAGAAGGTGGTCATCGACGGTGGCCTGGAGGCGGGCCAGACGGTGGTCACGGTGGGCGGCCAACTGCTCCATCCGGGCCAGGTGGTCGAGGTGGCCCAGCCGCCGCAGCCGACCCAGAGCACCGCCAGCCGCGACGCCGTGGGCGGAGGCCAGCCATGA", "partial": "0", "query_start": 1339, "query_end": 1443, "orf_dna_sequence": "ATGATCCTGCAGCGCGGCGGTTTGCAGCTCGAATTCTTCCCCTATCCTGACCTCGACCCAGCTACGAGCTCGTTCGGCTGTTGCCTGCGGTTGGATGATCTCGATGCCATGGTGGCATTGGTGAACGCGGCGGGAGCCGAGGAAAAAAGCACCGGCTGGCCGCGCTTCAAAGCTCCGCAACTGGAGGCGAGCGGCCTGAGGATCGGCTACCTGATCGATCCCGACTGCACGCTGGTGCGGCTGATCCAGAACCCCGACTGA", "orf_prot_sequence": "MILQRGGLQLEFFPYPDLDPATSSFGCCLRLDDLDAMVALVNAAGAEEKSTGWPRFKAPQLEASGLRIGYLIDPDCTLVRLIQNPD", "perc_identity": 28.57}}, "NODE_44_length_4295_cov_23.2123_3 # 1846 # 2862 # -1 # ID=44_3;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.571": {"gnl|BL_ORD_ID|582|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "622", "ARO_accession": "3002136", "ARO_name": "DHA-7", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 265, "bit_score": 538.88, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGSGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTCCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|817|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "868", "ARO_accession": "3002132", "ARO_name": "DHA-1", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 265, "bit_score": 538.11, "cvterm_id": "35750", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|781|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "829", "ARO_accession": "3002148", "ARO_name": "DHA-17", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 537.339, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVA VVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAVVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAVVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGTGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1332|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1418", "ARO_accession": "3002135", "ARO_name": "DHA-6", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 536.954, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKS SKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSTSKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSTSKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCACCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1694|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1793", "ARO_accession": "3002145", "ARO_name": "DHA-14", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 536.569, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGCACTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1599|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1695", "ARO_accession": "3002138", "ARO_name": "DHA-5", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 535.413, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKG+PYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGRPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGRPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGACATTCCCGGGATGGCGGTTGCCGTCTCTGTAAAGGGCAGGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGCACTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGCATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGTTACTATAAAACCGCCGCGATTAATCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1900|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2015", "ARO_accession": "3002134", "ARO_name": "DHA-3", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 263, "bit_score": 535.028, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVP+SAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMN+EPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPDSAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNIEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPDSAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNIEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGATAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCAGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATTGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.25, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1693|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1792", "ARO_accession": "3002151", "ARO_name": "DHA-20", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 535.028, "cvterm_id": "36934", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCCCTGCTGGCATTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGACGCTGAATGACCCGGCAGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACACTGTTGGATCTGGCCACCTACACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCAGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGCGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACCGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1135|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1207", "ARO_accession": "3002144", "ARO_name": "DHA-13", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 263, "bit_score": 534.258, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATATCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACGCTGCTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCATCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.25, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|26|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "32", "ARO_accession": "3002146", "ARO_name": "DHA-15", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 264, "bit_score": 534.258, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPG MRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGYMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGYMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCTATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGCGCAACAACTGGTTTCGGCGCCTATGTCGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.62, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2744|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3581", "ARO_accession": "3002140", "ARO_name": "DHA-9", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 533.487, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "M KS+SATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQS YAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MTKSVSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSHYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MTKSVSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSHYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGACAAAATCTGTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCAGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCATTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "1", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1555|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1649", "ARO_accession": "3002152", "ARO_name": "DHA-21", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 261, "bit_score": 533.102, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCTGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGACGTTGAATGACCCGGCAGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACACTGCTGGATCTGGCTACCTACACCGCAGGCGGGCTGCCGTTACAGGTGCCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGCATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACGGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.49, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1004|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1071", "ARO_accession": "3002153", "ARO_name": "DHA-22", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 263, "bit_score": 533.102, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDS IKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALND AAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSAIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDLAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSAIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDLAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCGCCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCAGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCTGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 99.25, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1780|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1883", "ARO_accession": "3002141", "ARO_name": "DHA-10", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 260, "bit_score": 531.561, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYTAGGLPLQVPD VKSRADLL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDEVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDEVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCTGTCTCTGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGACGCTGAATGACCCGGCGGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAAGGGATCACGCTGCTGGATCTGGCCACCTACACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGAGGTGAAAAGCCGTGCGGATCTGCTGCATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCAGCGGGGATGCCGTATGAGCAGTTGCTGACCGCGCGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACCGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCAGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACTGCCGCGATTAATCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGCGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.11, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|166|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "180", "ARO_accession": "3002150", "ARO_name": "DHA-19", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 262, "bit_score": 531.561, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSP QLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPEQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPEQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTACGGTTTTGCCGATGTTCAGGCAAAACAGCCTGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATATCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACGCTGCTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCATCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGAACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCATTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.87, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1385|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1472", "ARO_accession": "3002149", "ARO_name": "DHA-18", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 260, "bit_score": 528.865, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKE ALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPES QS+YAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESVQSRYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESVQSRYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCAGCGGTGGTGGACAGCACTATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTATCCGTAAAGGGCAAGCCCTATTATTTTAACTATGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGACGGCGCTGAATGATCCGGCGGCAAAATATCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACGCTGCTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTACCGGATGCGGTGAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCATCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAATGCGGCGGGGATGCCGTATGAGCAGTTGCTGACCGCGCGGATCCTGGCACCGCTGGGATTATCTCACACCTTTATTACCGTGCCGGAAAGTGTGCAAAGCCGGTATGCGTACGGCTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTCGCCCAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGTGTGACCAACGAGGTCGCATTGCAGCCGCATCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 98.11, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|294|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "315", "ARO_accession": "3002133", "ARO_name": "DHA-2", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 258, "bit_score": 528.48, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM LNDPA KYQPELALPQWKGITLLDLATYT GGLPLQVPDAVK+RA+LL+FYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMMLNDPAEKYQPELALPQWKGITLLDLATYTTGGLPLQVPDAVKNRAELLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMMLNDPAEKYQPELALPQWKGITLLDLATYTTGGLPLQVPDAVKNRAELLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCTGTAAAGGGCAAGCCCTATTATTTCAATTATGGTTTTGCCGATGTTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTGGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGATGTTGAATGACCCGGCAGAAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACACTGCTGGATCTGGCCACCTACACCACAGGCGGGCTGCCGTTACAGGTGCCGGATGCGGTGAAAAACCGTGCGGAACTGCTGCACTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCAGCGGGGATGCCGTATGAGCAGTTGCTGACCGCGCGGATCCTGGCACCGCTGGGATTATCTCACACCTTTATTACCGTGCCGGAAAGCGCGCAAAGCCAGTATGCGTACGGCTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAGTCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAGATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAACGAGGTCGCACTGCAGCCGCACCCGGTAACAGACAACCAGGTTCAGCCGTATAACCGTGCTTCCTGGGTGCATAAAACGGGGGCAACAACTGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCGCTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 97.36, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|797|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "846", "ARO_accession": "3002143", "ARO_name": "DHA-12", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 255, "bit_score": 522.316, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD++AKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEM+LNDPAAKY+PEL  PQWKGITLLDLATYTAGGLPLQVPDAVKSRADLL+FYQQWQPS KPGDMRLYANSSIGLFGALTANAAGMPYEQLLT RIL+PLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_db": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVEAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMSLNDPAAKYRPELTQPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTTRILSPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVEAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMSLNDPAAKYRPELTQPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSWKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTTRILSPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIVNGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGATTTCTGCCCTGCTGGCGTTTTCCGCCCCGGGGTTTTCCGCCGCTGACAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCAGTTGCTGTTTCCGTAAAGGGCAAGCCCTATTATTTCAACTATGGTTTTGCCGATGTTGAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCAGTTTCCGTGGCGAAAAAAGAGATGTCCCTGAATGACCCGGCGGCAAAATACCGGCCTGAACTGACACAACCGCAGTGGAAGGGGATCACATTGCTCGATCTGGCTACTTATACCGCAGGCGGGCTGCCGTTACAGGTGCCGGACGCGGTGAAAAGCCGTGCGGATCTGTTGCATTTCTATCAGCAGTGGCAGCCGTCATGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCCAACGCCGCAGGAATGCCGTATGAGCAGTTGCTGACCACGCGTATCCTGTCTCCGCTGGGGTTATCACACACCTTTATTACCGTGCCGGAAAGCGCGCAAAGCCAGTATGCGTACGGCTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCAGAATCTTACGGGGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAACCGTCACGGGCCGGTAATGCGGATCTGGAAATGGCAATGTATCTTGCACAGACCCGCTACTATAAAACCGCCGCGATTAACCAGGGGCTGGGCTGGGAAATGTATGATTGGCCGCAGCAGAAGGACATGATCGTGAACGGCGTGACCAATGAAGTCGCATTGCAGCCGCATCCGGTAACCGACAATCAGGTGCAGCCGTACAACCGCGCTTCCTGGGTGCATAAAACGGGGGCGACAACCGGTTTCGGCGCCTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATCCTGGCGAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCTGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|393|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "DHA-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "423", "ARO_accession": "3002147", "ARO_name": "DHA-16", "ARO_category": {"36207": {"category_aro_accession": "3000068", "category_aro_cvterm_id": "36207", "category_aro_name": "DHA beta-lactamase", "category_aro_description": "DHA beta-lactamases are plasmid-mediated AmpC \u03b2-lactamases that confer resistance to cephamycins and oxyimino-cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.29146e-178, "max_identities": 243, "bit_score": 495.352, "cvterm_id": "36917", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSLSATL+SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFAD+QAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKE +LNDPA KYQPEL  PQWKGITLLDLATYTAGGLPLQVP+AVKS  DLL+FYQQWQPS +PG MRLYANSSIGLFGALTA AAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKN +PVRV+ G LDAESYGVKSASKDMLRWAE+NM PSRAGNA", "sequence_from_db": "MKKSLSATLVSALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETSLNDPAVKYQPELTQPQWKGITLLDLATYTAGGLPLQVPEAVKSSEDLLHFYQQWQPSWQPGKMRLYANSSIGLFGALTATAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNNQPVRVTGGPLDAESYGVKSASKDMLRWAEINMSPSRAGNA", "sequence_from_broadstreet": "MKKSLSATLVSALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKETSLNDPAVKYQPELTQPQWKGITLLDLATYTAGGLPLQVPEAVKSSEDLLHFYQQWQPSWQPGKMRLYANSSIGLFGALTATAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNNQPVRVTGGPLDAESYGVKSASKDMLRWAEINMSPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATCTGCAACACTGGTTTCCGCCCTGCTGGCCTTTTCTGCCCCGGGGTTCTCTGCCGCTGATAATGTCGCGGCAGTCGTCGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATCCCCGGGATGGCGGTTGCTGTCTCCGTAAAGGGAAAACCGTATTACTTCAACTATGGTTTTGCGGATGTGCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAACTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCCGTGGCGAAAAAAGAGACGTCGCTGAATGACCCGGCAGTCAAATACCAGCCTGAACTGACACAGCCGCAGTGGAAAGGGATCACATTACTGGATCTGGCCACCTATACCGCAGGCGGGCTGCCGTTACAGGTGCCGGAAGCGGTGAAAAGCAGTGAGGATCTGCTGCATTTCTATCAGCAGTGGCAGCCGTCATGGCAACCGGGAAAGATGCGTCTGTATGCGAACAGCAGTATCGGCCTGTTCGGTGCGCTGACCGCGACAGCGGCGGGAATGCCTTATGAGCAGCTGCTGACCGCACGTATCCTGGCGCCGCTGGGGTTATCACATACCTTTATTACTGTACCGGAAAGTGCGCAAAGTCAGTATGCATACGGTTATAAAAACAATCAGCCGGTACGGGTGACGGGGGGACCGCTCGATGCGGAATCTTACGGGGTAAAATCCGCCTCAAAAGATATGCTGCGCTGGGCAGAAATCAATATGTCGCCGTCACGGGCGGGCAATGCGGATCTGGAAATGGCGATGTATCTCGCACAGACCCGTTACTATAAAACGGCGGCAATCAACCAGGGACTGGGCTGGGAGATGTATGACTGGCCGCAGCAGAAAGATATGATCATTAACGGCGTGACCAATGAAGTGGCATTGCAGCCGCATCCGGTAACGGATAATCAGGTTCAGCCGTATAACCGCGCTTCCTGGGTACATAAAACAGGAGCAACAACCGGTTTCGGTGCTTATGTGGCCTTTATTCCGGAAAAACAGGTGGCGATTGTGATTCTGGCAAATAAAAACTACCCGAATACCGAAAGAGTCAAAGCCGCACAGGCTATTTTGAGTGCACTGGAATAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 91.7}, "gnl|BL_ORD_ID|1415|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-108", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1504", "ARO_accession": "3002120", "ARO_name": "CMY-108", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.66173e-110, "max_identities": 160, "bit_score": 322.398, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWHILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACTGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAGGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCACATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.61}, "gnl|BL_ORD_ID|1728|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-87", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1829", "ARO_accession": "3002100", "ARO_name": "CMY-87", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.04103e-109, "max_identities": 159, "bit_score": 321.627, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ LNDP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAACGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|37|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-114", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "46", "ARO_accession": "3002125", "ARO_name": "CMY-114", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.04103e-109, "max_identities": 158, "bit_score": 321.627, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATTACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1809|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-47", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1915", "ARO_accession": "3002058", "ARO_name": "CMY-47", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.62599e-109, "max_identities": 157, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGAGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGTTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1697|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-119", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1796", "ARO_accession": "3002130", "ARO_name": "CMY-119", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.66175e-109, "max_identities": 159, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F++A     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWIQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWIQVNMDASRVQEKMLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAAEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAACTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGACCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGTTGGATTCAGGTCAACATGGATGCCAGCCGCGTTCAGGAGAAAATGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGTGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGCTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|729|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-113", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "775", "ARO_accession": "3002124", "ARO_name": "CMY-113", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.66175e-109, "max_identities": 158, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDAS", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASLVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGGCAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCTCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.08}, "gnl|BL_ORD_ID|193|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-105", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "208", "ARO_accession": "3002117", "ARO_name": "CMY-105", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.8128e-109, "max_identities": 157, "bit_score": 321.242, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1965|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-36", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2134", "ARO_accession": "3002047", "ARO_name": "CMY-36", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.02107e-109, "max_identities": 159, "bit_score": 320.857, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG   +A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVPE+ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACTGTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCTTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCAGAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCACAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|241|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-65", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "261", "ARO_accession": "3002078", "ARO_name": "CMY-65", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.35345e-109, "max_identities": 157, "bit_score": 320.857, "cvterm_id": "39093", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|316|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-51", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "340", "ARO_accession": "3002062", "ARO_name": "CMY-51", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.4052e-109, "max_identities": 158, "bit_score": 320.857, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ LNDP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLNDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAACGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|641|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-75", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "683", "ARO_accession": "3002088", "ARO_name": "CMY-75", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.65252e-109, "max_identities": 157, "bit_score": 320.857, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1109|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-81", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1178", "ARO_accession": "3002094", "ARO_name": "CMY-81", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.15666e-109, "max_identities": 157, "bit_score": 320.472, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIVNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIVNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDYVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGTCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATTACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|795|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-117", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "844", "ARO_accession": "3002128", "ARO_name": "CMY-117", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.48124e-109, "max_identities": 158, "bit_score": 320.472, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRA", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S A", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHA", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHAQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGCTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGTACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2631, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.62}, "gnl|BL_ORD_ID|854|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-50", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "911", "ARO_accession": "3002061", "ARO_name": "CMY-50", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.59669e-109, "max_identities": 158, "bit_score": 320.472, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWCIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGTGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCTAACCCGGTCCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1074|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-86", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1140", "ARO_accession": "3002099", "ARO_name": "CMY-86", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.14286e-109, "max_identities": 159, "bit_score": 320.087, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEVAWHILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTCTCCACGTTTGCCGCAGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGTGGCCTGGCACATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 60.23}, "gnl|BL_ORD_ID|1163|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-53", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1236", "ARO_accession": "3002064", "ARO_name": "CMY-53", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.18816e-109, "max_identities": 158, "bit_score": 320.087, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGICLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGICLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCTGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAATAAAAGCTATCCTAACCCTGCCCGCGTCGAGGCGGCCTGGCGTATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1172|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-72", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1247", "ARO_accession": "3002085", "ARO_name": "CMY-72", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.93021e-109, "max_identities": 157, "bit_score": 320.087, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|791|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-44", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "839", "ARO_accession": "3002055", "ARO_name": "CMY-44", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.27473e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCACCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1412|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-49", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1501", "ARO_accession": "3002060", "ARO_name": "CMY-49", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.61745e-109, "max_identities": 157, "bit_score": 320.087, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV V+PGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALHTVEVNPPAPAVKASWVHKTGSTGGFGSYVAFIPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCATTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACAGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTACTCCTGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCCCGTTGGATTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGTGACAGCAAAGTGGCATTGGCAGCGCTTCACACCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCATTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|339|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-83", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "364", "ARO_accession": "3002096", "ARO_name": "CMY-83", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.19504e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "39584", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL  N +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVNPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVNPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCGTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAACCCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCGCCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGGCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCCCTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAAGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|77|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-55", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "88", "ARO_accession": "3002066", "ARO_name": "CMY-55", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.33125e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGEAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGEAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACATGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGAAGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|288|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-35", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "309", "ARO_accession": "3002046", "ARO_name": "CMY-35", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.68503e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACATGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|267|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-60", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "288", "ARO_accession": "3002073", "ARO_name": "CMY-60", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.21376e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFIGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFIGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTATCGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1097|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-94", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1163", "ARO_accession": "3002107", "ARO_name": "CMY-94", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.70013e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVASAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATCGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1574|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-68", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1668", "ARO_accession": "3002081", "ARO_name": "CMY-68", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.95547e-109, "max_identities": 156, "bit_score": 319.701, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPG+AVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGIAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGIAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATTGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGTTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|287|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-118", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "308", "ARO_accession": "3002129", "ARO_name": "CMY-118", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.95547e-109, "max_identities": 158, "bit_score": 319.701, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|2685|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-132", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "550", "model_id": "3577", "ARO_accession": "3003652", "ARO_name": "CMY-132", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.04245e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKKLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAAACTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|969|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-102", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1029", "ARO_accession": "3002114", "ARO_name": "CMY-102", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.58468e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNCTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNCTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATTGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTAGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|560|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "600", "ARO_accession": "3002013", "ARO_name": "CMY-2", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35927": {"category_aro_accession": "0000008", "category_aro_cvterm_id": "35927", "category_aro_name": "cefoxitin", "category_aro_description": "Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.67854e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|2701|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-133", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3578", "ARO_accession": "3003653", "ARO_name": "CMY-133", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.06436e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGNDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAACGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|676|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-33", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "719", "ARO_accession": "3002044", "ARO_name": "CMY-33", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.17469e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|83|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-56", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "95", "ARO_accession": "3002067", "ARO_name": "CMY-56", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.46733e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKTDSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAACTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|662|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-116", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "705", "ARO_accession": "3002127", "ARO_name": "CMY-116", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.57084e-109, "max_identities": 157, "bit_score": 319.316, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTAGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGTACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1346|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1433", "ARO_accession": "3002029", "ARO_name": "CMY-18", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.66286e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGNGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|491|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "525", "ARO_accession": "3002024", "ARO_name": "CMY-13", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.67549e-109, "max_identities": 157, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F++A     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCATTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACTGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCACGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1034|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1103", "ARO_accession": "3002028", "ARO_name": "CMY-17", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.78127e-109, "max_identities": 158, "bit_score": 319.316, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAFAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTTGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1488|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-73", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1585", "ARO_accession": "3002086", "ARO_name": "CMY-73", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.17673e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV V+PGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVLYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYLPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVLYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYLPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPTVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTCTCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTTGCCAGAACTGACAGGCAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACAGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTACTCCTGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCCCGTTGGATTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGTGACAGCAAAGTGGCATTGGCAGCGCTTCCCACCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGTTCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTACAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|901|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-69", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "963", "ARO_accession": "3002082", "ARO_name": "CMY-69", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.17673e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALPALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGCCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1193|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-115", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1268", "ARO_accession": "3002126", "ARO_name": "CMY-115", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.1896e-108, "max_identities": 157, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  KGKPYYF +G ADI    PVT++TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM  W + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYKGKPYYFTWGKADIANNHPVTQHTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYKGKPYYFTWGKADIANNHPVTQHTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACAAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCATACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCACTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTATCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1451|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1543", "ARO_accession": "3002033", "ARO_name": "CMY-22", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.20261e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAYWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGTACTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1761|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-67", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1864", "ARO_accession": "3002080", "ARO_name": "CMY-67", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.24248e-108, "max_identities": 157, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEVAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGTTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGACCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTACACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGTGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|792|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "840", "ARO_accession": "3002031", "ARO_name": "CMY-20", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.32709e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCCGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGTTTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAACAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTCCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1818|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-34", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1926", "ARO_accession": "3002045", "ARO_name": "CMY-34", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.34075e-108, "max_identities": 158, "bit_score": 318.931, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTAGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1081|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-63", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1147", "ARO_accession": "3002076", "ARO_name": "CMY-63", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.75958e-108, "max_identities": 158, "bit_score": 318.546, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKKLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGAGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAAACTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|86|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-48", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "98", "ARO_accession": "3002059", "ARO_name": "CMY-48", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.8782e-108, "max_identities": 157, "bit_score": 318.546, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|260|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-110", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "281", "ARO_accession": "3002071", "ARO_name": "CMY-110", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.9195e-108, "max_identities": 157, "bit_score": 318.546, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSKFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSKFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWGIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCAAGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGCATGGCCGTGGCAATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGGGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCGGCTCGCGTAGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1494|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-64", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1591", "ARO_accession": "3002077", "ARO_name": "CMY-64", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.11684e-108, "max_identities": 157, "bit_score": 318.546, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMA+AV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAIAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAIAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTATCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTATTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAAGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|725|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-24", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "771", "ARO_accession": "3002035", "ARO_name": "CMY-24", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.25955e-108, "max_identities": 158, "bit_score": 318.546, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVYVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVYVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTATACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|653|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-66", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "695", "ARO_accession": "3002079", "ARO_name": "CMY-66", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.33447e-108, "max_identities": 156, "bit_score": 318.161, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDAS", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASLVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGTGGTAAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGGCAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCTCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.32}, "gnl|BL_ORD_ID|1103|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-46", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1170", "ARO_accession": "3002057", "ARO_name": "CMY-46", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.38579e-108, "max_identities": 158, "bit_score": 318.161, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPKNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPKNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGAAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACACTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|162|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-25", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "176", "ARO_accession": "3002036", "ARO_name": "CMY-25", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.51909e-108, "max_identities": 158, "bit_score": 318.161, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V  +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACTGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|82|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-79", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "94", "ARO_accession": "3002092", "ARO_name": "CMY-79", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.68892e-108, "max_identities": 156, "bit_score": 318.161, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQDKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGATAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGTACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1400|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-37", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1489", "ARO_accession": "3002048", "ARO_name": "CMY-37", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.19987e-108, "max_identities": 158, "bit_score": 318.161, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY  EL   QW+GI+LL LATYTAGGLPLQ+PD V  +  LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWSELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWSELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAAIPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPIRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGTCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAACCGCATTACTGCACTTTTATCAAAACTGGCAGCCTCAATGGGCTCCGGGCGCTAAGAGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAGCCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGATGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCACGCTGGGTTCAGGCCAACATGGATGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAGGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGATTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTATCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|839|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-90", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "894", "ARO_accession": "3002103", "ARO_name": "CMY-90", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.23485e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+P  V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGGTGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1948|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2065", "ARO_accession": "3002016", "ARO_name": "CMY-5", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.37865e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "36788", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+  +DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGTTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACTTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1607|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-57", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1704", "ARO_accession": "3002068", "ARO_name": "CMY-57", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.37865e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQ DAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQFDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQFDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAATTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1543|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-111", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1638", "ARO_accession": "3002122", "ARO_name": "CMY-111", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.37865e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "36783", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLD E+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDVEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDVEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGTCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1595|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1691", "ARO_accession": "3002042", "ARO_name": "CMY-31", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.52883e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPG+LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACGACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|630|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-27", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "672", "ARO_accession": "3002038", "ARO_name": "CMY-27", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.8079e-108, "max_identities": 158, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYACGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYACGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGTGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1878|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1988", "ARO_accession": "3002018", "ARO_name": "CMY-7", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.15396e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|280|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-95", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "301", "ARO_accession": "3002108", "ARO_name": "CMY-95", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.15396e-108, "max_identities": 157, "bit_score": 317.775, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVASAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGCTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATCGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|835|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-74", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "889", "ARO_accession": "3002087", "ARO_name": "CMY-74", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.68171e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "39584", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRVGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGCATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTGTTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAATAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|617|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-104", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "658", "ARO_accession": "3002116", "ARO_name": "CMY-104", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.83694e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "39654", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   P   RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNHTITPLMQKQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPSTKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASQ", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNHTITPLMQKQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPSTKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVDAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCACACCATCACCCCGTTGATGCAGAAGCAGGCTATTCCGGGGATGGCCGTTGCAGTTATCTACCAGGGTAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGTGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAGCCACAATGGACTCCGAGCACTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCGATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAAAAAACACTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGTTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTACATAAAACGGGATCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGCCCGCGTCGATGCAGCCTGGCGTATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|465|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-28", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "495", "ARO_accession": "3002039", "ARO_name": "CMY-28", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.83694e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAACAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|2505|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2843", "ARO_accession": "3004290", "ARO_name": "Escherichia coli ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.01027e-108, "max_identities": 153, "bit_score": 317.39, "cvterm_id": "36849", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": " K +L A LI+A    S   F+A   +  +V  TI PL+ QQ IPGMAVAV  +GKPYYF +G+ADI  KQPVT+ TLFELGSVSKTFTGVLG  ++A+ E+ L+DP  KY PEL   QW GITLL LATYTAGGLPLQVPD VKS +DLL FYQ WQP+  PG  RLYANSSIGLFGAL    +G+ +EQ +  R+  PL L+HT+I VP + +  YA+GY+  K V VSPG LDAE+YGVKS  +DM RW + N++P", "sequence_from_db": "FKTTLCALLITA----SCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKP", "sequence_from_broadstreet": "MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ", "dna_sequence_from_broadstreet": "ATGTTCAAAACGACGCTCTGCGCCTTATTAATTACCGCCTCTTGCTCCACATTTGCTGCCCCTCAACAAATCAACGATATTGTGCATCGCACAATTACCCCGCTTATAGAGCAACAAAAGATCCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTAAACCTTATTACTTTACCTGGGGCTATGCGGACATCGCCAAAAAGCAGCCCGTCACACAGCAAACGTTGTTTGAGTTAGGTTCGGTCAGCAAAACATTTACTGGCGTGCTTGGTGGCGACGCTATTGCTCGAGGGGAAATCAAGTTAAGCGATCCCACAACAAAATACTGGCCTGAACTTACCGCTAAACAGTGGAATGGGATCACACTATTACATCTCGCAACCTACACTGCTGGCGGCCTGCCATTGCAGGTGCCGGATGAGGTGAAATCCTCAAGCGACTTGCTGCGCTTCTATCAAAACTGGCAGCCTGCATGGGCTCCAGGAACACAACGTCTGTATGCCAACTCCAGTATCGGTTTGTTCGGCGCACTGGCTGTGAAGCCGTCTGGTTTGAGTTTTGAGCAGGCGATGCAAACTCGTGTCTTCCAGCCACTCAAACTCAACCATACGTGGATTAATGTACCGCCCGCAGAAGAAAAGAATTACGCCTGGGGATATCGCGAAGGTAAGGCAGTGCATGTTTCGCCTGGGGCGTTAGATGCTGAAGCTTATGGTGTGAAGTCGACCATTGAAGATATGGCCCGCTGGGTGCAAAGCAATTTAAAACCCCTTGATATCAATGAGAAAACGCTTCAACAAGGGATACAACTGGCACAATCTCGCTACTGGCAAACCGGCGATATGTATCAGGGCCTGGGCTGGGAAATGCTGGACTGGCCGGTAAATCCTGACAGCATCATTAACGGCAGTGACAATAAAATTGCACTGGCAGCACGCCCCGTAAAAGCGATTACGCCCCCAACTCCTGCAGTACGCGCATCATGGGTACATAAAACAGGGGCGACCGGCGGATTTGGTAGCTATGTCGCGTTTATTCCAGAAAAAGAGCTGGGTATCGTGATGCTGGCAAACAAAAACTATCCCAATCCAGCGAGAGTCGACGCCGCCTGGCAGATTCTTAACGCTCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.07}, "gnl|BL_ORD_ID|2504|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2843", "ARO_accession": "3004290", "ARO_name": "Escherichia coli ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35971": {"category_aro_accession": "0000054", "category_aro_cvterm_id": "35971", "category_aro_name": "penicillin", "category_aro_description": "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.01027e-108, "max_identities": 153, "bit_score": 317.39, "cvterm_id": "36849", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": " K +L A LI+A    S   F+A   +  +V  TI PL+ QQ IPGMAVAV  +GKPYYF +G+ADI  KQPVT+ TLFELGSVSKTFTGVLG  ++A+ E+ L+DP  KY PEL   QW GITLL LATYTAGGLPLQVPD VKS +DLL FYQ WQP+  PG  RLYANSSIGLFGAL    +G+ +EQ +  R+  PL L+HT+I VP + +  YA+GY+  K V VSPG LDAE+YGVKS  +DM RW + N++P", "sequence_from_db": "FKTTLCALLITA----SCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKP", "sequence_from_broadstreet": "MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ", "dna_sequence_from_broadstreet": "ATGTTCAAAACGACGCTCTGCGCCTTATTAATTACCGCCTCTTGCTCCACATTTGCTGCCCCTCAACAAATCAACGATATTGTGCATCGCACAATTACCCCGCTTATAGAGCAACAAAAGATCCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTAAACCTTATTACTTTACCTGGGGCTATGCGGACATCGCCAAAAAGCAGCCCGTCACACAGCAAACGTTGTTTGAGTTAGGTTCGGTCAGCAAAACATTTACTGGCGTGCTTGGTGGCGACGCTATTGCTCGAGGGGAAATCAAGTTAAGCGATCCCACAACAAAATACTGGCCTGAACTTACCGCTAAACAGTGGAATGGGATCACACTATTACATCTCGCAACCTACACTGCTGGCGGCCTGCCATTGCAGGTGCCGGATGAGGTGAAATCCTCAAGCGACTTGCTGCGCTTCTATCAAAACTGGCAGCCTGCATGGGCTCCAGGAACACAACGTCTGTATGCCAACTCCAGTATCGGTTTGTTCGGCGCACTGGCTGTGAAGCCGTCTGGTTTGAGTTTTGAGCAGGCGATGCAAACTCGTGTCTTCCAGCCACTCAAACTCAACCATACGTGGATTAATGTACCGCCCGCAGAAGAAAAGAATTACGCCTGGGGATATCGCGAAGGTAAGGCAGTGCATGTTTCGCCTGGGGCGTTAGATGCTGAAGCTTATGGTGTGAAGTCGACCATTGAAGATATGGCCCGCTGGGTGCAAAGCAATTTAAAACCCCTTGATATCAATGAGAAAACGCTTCAACAAGGGATACAACTGGCACAATCTCGCTACTGGCAAACCGGCGATATGTATCAGGGCCTGGGCTGGGAAATGCTGGACTGGCCGGTAAATCCTGACAGCATCATTAACGGCAGTGACAATAAAATTGCACTGGCAGCACGCCCCGTAAAAGCGATTACGCCCCCAACTCCTGCAGTACGCGCATCATGGGTACATAAAACAGGGGCGACCGGCGGATTTGGTAGCTATGTCGCGTTTATTCCAGAAAAAGAGCTGGGTATCGTGATGCTGGCAAACAAAAACTATCCCAATCCAGCGAGAGTCGACGCCGCCTGGCAGATTCTTAACGCTCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.07}, "gnl|BL_ORD_ID|1279|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-101", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1364", "ARO_accession": "3002113", "ARO_name": "CMY-101", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.10717e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCCAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACGCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCATACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGTTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|251|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "271", "ARO_accession": "3002015", "ARO_name": "CMY-4", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.45145e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCAGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTACAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|711|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-80", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "757", "ARO_accession": "3002093", "ARO_name": "CMY-80", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.57129e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAAD---NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GK YYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+I VP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEPQIADIVNRTITPLMQEQAIPGMAVAVIYQGKSYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEPQIADIVNRTITPLMQEQAIPGMAVAVIYQGKSYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCATTCTCCACGTTTGCCGCCGCCAAAACAGAACCACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAATCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTAAAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGTATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1021|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1089", "ARO_accession": "3002025", "ARO_name": "CMY-14", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.6322e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGATAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1323|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1409", "ARO_accession": "3002017", "ARO_name": "CMY-6", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.75601e-108, "max_identities": 158, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTTGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|1879|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-82", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1990", "ARO_accession": "3002095", "ARO_name": "CMY-82", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.27909e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCGTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGTGCCCTGGCGGTCAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCGCCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCGTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|622|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-43", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "664", "ARO_accession": "3002054", "ARO_name": "CMY-43", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.34773e-108, "max_identities": 157, "bit_score": 317.39, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLF AL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFAALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFAALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGCCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1556|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1650", "ARO_accession": "3002026", "ARO_name": "CMY-15", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.70237e-108, "max_identities": 158, "bit_score": 317.005, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.85}, "gnl|BL_ORD_ID|804|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-58", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "854", "ARO_accession": "3002072", "ARO_name": "CMY-58", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.70237e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+Y VKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYCVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYCVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATTGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1365|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-112", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1454", "ARO_accession": "3002123", "ARO_name": "CMY-112", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.77563e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTACCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1539|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-78", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1634", "ARO_accession": "3002091", "ARO_name": "CMY-78", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.07681e-108, "max_identities": 156, "bit_score": 317.005, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+P  V  +A+LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPGDVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGGTGACGTTACGGATAAAGCCGAATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1321|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-62", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1407", "ARO_accession": "3002075", "ARO_name": "CMY-62", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.55385e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLF AL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFSALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFSALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTAGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|262|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-85", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "283", "ARO_accession": "3002098", "ARO_name": "CMY-85", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.97586e-108, "max_identities": 156, "bit_score": 317.005, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL   ++GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY   KP+ VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPLHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYLEGKPLHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQLGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAATCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCTCGAAGGGAAGCCTTTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCTGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|2601|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "BIL-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "780", "model_id": "3562", "ARO_accession": "3004755", "ARO_name": "BIL-1", "ARO_category": {"42866": {"category_aro_accession": "3004754", "category_aro_cvterm_id": "42866", "category_aro_name": "BIL Beta-lactamase", "category_aro_description": "BIL beta-lactamase is plasmid-borne and is a class C beta-lactamase.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.15119e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+ Y+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGRDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWAYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGRDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWAYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDTKVALAAVPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVIVANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCCGCGATGCTATCGCGCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGCGTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACACGAAAGTGGCATTGGCAGCCGTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATCGTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|52|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-42", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "62", "ARO_accession": "3002053", "ARO_name": "CMY-42", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35927": {"category_aro_accession": "0000008", "category_aro_cvterm_id": "35927", "category_aro_name": "cefoxitin", "category_aro_description": "Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.15119e-108, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHSSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHSSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACAGTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1496|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-99", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1593", "ARO_accession": "3002070", "ARO_name": "CMY-99", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.06971e-107, "max_identities": 157, "bit_score": 316.62, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPATAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCACCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1738|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-59", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1840", "ARO_accession": "3002069", "ARO_name": "CMY-59", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.08024e-107, "max_identities": 157, "bit_score": 317.005, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "GPGHLFAFNYGTDFMMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "GGGCCCGGACACCTTTTTGCTTTTAATTACGGAACTGATTTCATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGCTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|743|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "790", "ARO_accession": "3002043", "ARO_name": "CMY-32", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.15429e-107, "max_identities": 157, "bit_score": 316.62, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSP QLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPEQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPEQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGAACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|918|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "972", "ARO_accession": "3002034", "ARO_name": "CMY-23", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30093e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35671", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDA +YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAGAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAGAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGGAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|593|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CFE-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "636", "ARO_accession": "3001856", "ARO_name": "CFE-1", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.34406e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTTRVLQPLKLAHTWITVPQSEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVVDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTTRVLQPLKLAHTWITVPQSEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVVDMTRWVQANMDASQVQEKTLQQGIKLAQSRYWRIGDMYQGLGWEMLNWPVKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTTTCCACCTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTACCAGGGAAAACCTTATTACTTTACCTGGGGTAAAGCTGATATCGCCAATAACCGTCCAGTCACTCAGCAAACGCTGTTTGAACTCGGCTCGGTCAGTAAAACGTTCAACGGCGTGCTGGGCGGCGATGCTATCGCTCGCGGCGAAATCAAGCTCAGCGATCCGGTCACGCAATACTGGCCTGAGCTGACGGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCGACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCCGACGACGTCACGGATAAAGCCGCCTTACTGCGTTTTTATCAAAACTGGCAGCCACAATGGGCACCGGGCGCTAAACGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCACTGGCGGTGAAACCTTCAGGCATGAGCTACGAAGAGGCGATGACCACCCGCGTCCTGCAGCCCTTAAAACTGGCGCATACATGGATTACGGTTCCACAGAGCGAACAAAAAGATTATGCATTGGGCTATCGCGAAGGAAAGCCTGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTATGGGGTAAAATCAAGCGTTGTCGATATGACCCGCTGGGTCCAGGCCAACATGGATGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGAATCAAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGTCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCAATAATTAACGGTAGCGACAGCAAAGTGGCGCTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCGCCTGCTGTGAAAGCATCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATTGTGATGCTGGCAAACAAGAGCTATCCAAACCCTGCTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1155|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-30", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1228", "ARO_accession": "3002041", "ARO_name": "CMY-30", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.35875e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV  SPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGGTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|54|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-70", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "64", "ARO_accession": "3002083", "ARO_name": "CMY-70", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.4662e-107, "max_identities": 156, "bit_score": 316.235, "cvterm_id": "39584", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ ++ R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMSKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMSKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGTATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACGCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGTGTGCTGGGCGGCGATGCTATAGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCAGTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCAGTGAAACCCTCAGGCATGAGCTACGAAGAGGCGATGTCCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCATACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|940|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-77", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "996", "ARO_accession": "3002090", "ARO_name": "CMY-77", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.51481e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "39655", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTATCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGATGCCGAAGCCTATGGCGTGAAATCCAGTGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCTGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1443|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1535", "ARO_accession": "3002027", "ARO_name": "CMY-16", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.70724e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|237|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "256", "ARO_accession": "3002032", "ARO_name": "CMY-21", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.70724e-107, "max_identities": 156, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPG+LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGKLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGKLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGAAAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1405|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LAT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1494", "ARO_accession": "3001857", "ARO_name": "LAT-1", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.80261e-107, "max_identities": 156, "bit_score": 316.235, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL + L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG   +A+ E+ L+DP  KY PEL   +W+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPG+LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCSAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKKWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCSALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKKWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTCCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAACCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGGAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACTGTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAAAAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCTTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACGACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1774|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1877", "ARO_accession": "3002023", "ARO_name": "CMY-12", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.82231e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTACAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|426|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-29", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "460", "ARO_accession": "3002040", "ARO_name": "CMY-29", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.82231e-107, "max_identities": 157, "bit_score": 316.235, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGTTCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGAGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1655|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-93", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1756", "ARO_accession": "3002106", "ARO_name": "CMY-93", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.00963e-107, "max_identities": 156, "bit_score": 315.849, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+  +DP   Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTHYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLRPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRVGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCGTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGCATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGATCGGTCAGTAAAACGTTCAACGGTGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGTTCAGCGATCCGGTCACGCATTACTGGCCTGAACTGACTGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCGTTACTACGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGTGCCCTGGCGGTCAAACCCTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCGCCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGCATCGAGCTTGCGCAGTCACGTTACTGGCGTGTTGGCGATATGTACCAGGGCCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAAGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTGGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|700|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-40", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "745", "ARO_accession": "3002051", "ARO_name": "CMY-40", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.19224e-107, "max_identities": 157, "bit_score": 315.849, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFG L    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM  W + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGTLAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGTLAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGYTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGGTTATCTACCAGGGAAAACCCTATTATTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGTCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCACGCTGGCGGTGAAACCCTCCGGTATGAGCTACGAAGAGGCGATGACCAGACGCGTTCTGCAGCCATTAAAGCTGGCGCATACCTGGATTACGGTTCCACAGAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAACCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCACTGGGTACAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAACAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCCGATTCGATCATCAACGGCAGCGACAGCAAAGTAGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTACACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1903|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-76", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2018", "ARO_accession": "3002089", "ARO_name": "CMY-76", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.75446e-107, "max_identities": 156, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVQPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGCAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|205|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-100", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "221", "ARO_accession": "3002112", "ARO_name": "CMY-100", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.78457e-107, "max_identities": 156, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL+FYQ WQP    G  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLHFYQNWQPQWASGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLHFYQNWQPQWASGAKRLYANSSIGLFGALAVKPSGMSYEEAMTKRVLHPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMTRWVQANMDASQVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPVKADSIISGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCTTCTTTCTCCACGTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCAATTCCGGGCATGGCCGTTGCGATTATCTATCAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCGTCCAGTCACTCAACAAACGCTGTTTGAACTCGGTTCGGTCAGTAAAACGTTCAACGGTGTGCTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGCAGTACTGGCCTGAACTGACGGGTAAGCAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCGGACGACGTTACGGATAAAGCCGCATTACTACACTTTTATCAAAACTGGCAGCCGCAATGGGCCTCAGGCGCTAAACGTCTTTATGCTAACTCCAGCATTGGTCTGTTTGGCGCCCTGGCGGTGAAACCTTCAGGCATGAGCTACGAAGAGGCGATGACCAAACGCGTCCTGCACCCCTTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAGCGAACAAAAAGATTATGCCTGGGGTTATCGCGAAGGAAAGCCAGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCCTACGGGGTGAAATCGAGCGTTATCGATATGACCCGTTGGGTTCAGGCCAACATGGACGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAGGGAATCGAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGCCTGGGTTGGGAGATGCTGAACTGGCCGGTGAAGGCCGACTCGATAATTAGCGGTAGCGACAGCAAAGTAGCACTGGCAGCGCTTCCTGCCGTTGAGGTAAACCCGCCCGCGCCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGCGGATTTGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAGAGCTACCCAAACCCTGTTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1912|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-84", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2027", "ARO_accession": "3002097", "ARO_name": "CMY-84", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.97226e-107, "max_identities": 155, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY P L   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPALTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPALTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGCACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTATCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|1019|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-41", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1086", "ARO_accession": "3002052", "ARO_name": "CMY-41", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.61467e-107, "max_identities": 155, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+A      +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCACAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTACCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|154|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-39", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "167", "ARO_accession": "3002050", "ARO_name": "CMY-39", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.61467e-107, "max_identities": 157, "bit_score": 315.464, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+I VP+S Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTATCCACGTTTGCCGCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCTGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTAAAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCAATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1513|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-38", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1613", "ARO_accession": "3002049", "ARO_name": "CMY-38", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.65418e-107, "max_identities": 157, "bit_score": 315.464, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQL+AE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLNAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLNAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTAACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAACTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|2712|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-135", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "740", "model_id": "3579", "ARO_accession": "3004778", "ARO_name": "CMY-135", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.64148e-107, "max_identities": 155, "bit_score": 315.079, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI     VT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD +  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHLVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHLVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCACTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCGCAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGGGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCTAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTGCCGCTGCAGATCCCCGATGACATTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAACTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTGCACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGCTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACAGGATCCACAGGCGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTAATGTTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|512|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-71", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "550", "ARO_accession": "3002084", "ARO_name": "CMY-71", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.69221e-107, "max_identities": 157, "bit_score": 315.079, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL      F+AA     +A  V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  K V VSPGQLDAE+YGVKS+  DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTAPFSTFAAAKTEQQIADTVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTAPFSTFAAAKTEQQIADTVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKKLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCCCTTTCTCCACGTTTGCCGCAGCCAAAACAGAACAACAGATTGCCGATACCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCACCAATAACCACCCAGTCACGCAGCAAACTCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCAGCCTGCTGCACTTAGCCACCTACACGGCAGGCGGCCTGCCGCTGCAGATCCCCGATGACGTTACGGATAAAGCCGCATTACTGCGTTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGGCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGGTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGAGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAAACTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.47}, "gnl|BL_ORD_ID|1426|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-45", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1516", "ARO_accession": "3002056", "ARO_name": "CMY-45", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.79535e-107, "max_identities": 156, "bit_score": 315.079, "cvterm_id": "36771", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPL++PD V+ +A LL+FYQ WQP   PG  RLY+NSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLKIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLKIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTVGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGAAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACTCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCCGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGTTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|1646|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-103", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1747", "ARO_accession": "3002115", "ARO_name": "CMY-103", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.90075e-107, "max_identities": 155, "bit_score": 315.079, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L   LL  S   F+A      +A +V+ TI PLM +Q IPGMAVA+  + KPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI+LL LATYTAGGLPLQ+PD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSICCAL---LLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSICCALLLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQGKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCTGCCACAAAAACAGAACAACAAATTGCCGATATCGTTAACCGCACCATCACACCACTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTGGCGATTATCTACGAGGAGAAACCTTATTACTTTACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAATTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGACGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCGGGGTATCAGCCTGCTGCACTTAGCCACCTATACAGCGGGTGGCCTACCGCTGCAGATCCCCGATGAAGTTACGGATAAAGCCGCATTACTGCGCTTTTATCAAAACTGGCAACCACAATGGACTCCGGGCGCTAAGCGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGTGCGCTGGCGGTGAAACCTTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAAAGCGAACAAAAAAATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATCGATATGGCCCGCTGGGTTCAGGCCAACATGGACGCCAGCCACGTTCAAGGGAAAACGCTCCAGCAGGGCATTGAGCTTGCGCAGTCTCGTTACTGGCGTATTGGTGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCAGCACCTGCCGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACAGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATAGTGATGCTGGCAAACAAAAGCTACCCCAACCCGGCTCGCGTCGAGGCGGCCTGGCGCATTCTTGAAAAACTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|1288|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-26", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1373", "ARO_accession": "3002037", "ARO_name": "CMY-26", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.17449e-107, "max_identities": 156, "bit_score": 315.079, "cvterm_id": "36788", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F++A     +A +V+ TI PLM +Q IPGMAVAV  +GK YYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+ I+LL LATYTAGGLPLQ+PD V  +  LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS   DM RW ++NM+ SR", "sequence_from_db": "MKKSLCCAL---LLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKTYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQDISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASR", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKTYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQDISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACGTTTGCCTCCGCCAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAAACCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGGTCGGTCAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGATATCAGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTACGGATAAAACCGCATTACTGCACTTTTATCAAAACTGGCAGCCGCAATGGGCTCCGGGCGCTAAGAGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGTATGAGCTACGAAGAGGCAATGACCAGACGCGTCCTGCAGCCATTAAAACTGGCGCATACCTGGATTACAGTTCCGCAAAGCGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCTGTACACGTTTCTCCGGGACAACTTGATGCCGAAGCCTATGGCGTGAAATCCAACGTTACCGATATGGCACGCTGGGTTCAGGTCAACATGGACGCCAGCCGCGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGTAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCGGCAGTGAAAGCCTCATGGGTGCATAAAACGGGATCCACTGGTGGATTTGGCAGCTACGTTGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.09}, "gnl|BL_ORD_ID|638|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-54", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "680", "ARO_accession": "3002065", "ARO_name": "CMY-54", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.00264e-106, "max_identities": 158, "bit_score": 314.309, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQ--LDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKSL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQ  LDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MKKSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLELDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLELDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGTTATGCTGCGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.4}, "gnl|BL_ORD_ID|813|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-61", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "864", "ARO_accession": "3002074", "ARO_name": "CMY-61", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.76199e-106, "max_identities": 155, "bit_score": 313.153, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "M +  +A L++A  +FS   F+AA     +A +V+ TI PLM +Q IPGMAVAV  +GKPYYF +G ADI    PVT+ TLFELGSVSKTF GVLG  ++A+ E+ L+DP  KY PEL   QW+GI LL LATYTAGGLPLQ+PD V+ +A LL+FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP++ Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S ", "sequence_from_db": "MNRYAAALLLTA--SFST--FAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASH", "sequence_from_broadstreet": "MMNRYAAALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAATCGTTATGCTGCAGCTCTGCTGCTGACAGCCTCTTTCTCCACATTTGCTGCCGCAAAAACAGAACAACAGATTGCCGATATCGTTAATCGCACCATCACCCCGTTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCCGTTATCTACCAGGGAAAACCCTATTATTTCACCTGGGGTAAAGCCGATATCGCCAATAACCACCCAGTCACGCAGCAAACGCTGTTTGAGCTAGGATCGGTTAGTAAGACGTTTAACGGCGTGTTGGGCGGCGATGCTATCGCCCGCGGCGAAATTAAGCTCAGCGATCCGGTCACGAAATACTGGCCAGAACTGACAGGCAAACAGTGGCAGGGTATCCGCCTGCTGCACTTAGCCACCTATACGGCAGGCGGCCTACCGCTGCAGATCCCCGATGACGTTAGGGATAAAGCCGCATTACTGCATTTTTATCAAAACTGGCAGCCGCAATGGACTCCGGGCGCTAAGCGACTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCGCTGGCGGTGAAACCCTCAGGAATGAGTTACGAAGAGGCAATGACCAGACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCGCAGAACGAACAAAAAGATTATGCCTGGGGCTATCGCGAAGGGAAGCCCGTACACGTTTCTCCGGGACAACTTGACGCCGAAGCCTATGGCGTGAAATCCAGCGTTATTGATATGGCCCGCTGGGTTCAGGCCAACATGGATGCCAGCCACGTTCAGGAGAAAACGCTCCAGCAGGGCATTGCGCTTGCGCAGTCTCGCTACTGGCGTATTGGCGATATGTACCAGGGATTAGGCTGGGAGATGCTGAACTGGCCGCTGAAAGCTGATTCGATCATCAACGGCAGCGACAGCAAAGTGGCATTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCCCCCGCAGTGAAAGCCTCATGGGTGCATAAAACGGGCTCCACTGGTGGATTTGGCAGCTACGTAGCCTTCGTTCCAGAAAAAAACCTTGGCATCGTGATGCTGGCAAACAAAAGCTATCCTAACCCTGTCCGTGTCGAGGCGGCCTGGCGCATTCTTGAAAAGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.71}, "gnl|BL_ORD_ID|276|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-98", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "297", "ARO_accession": "3002111", "ARO_name": "CMY-98", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.32545e-105, "max_identities": 155, "bit_score": 311.227, "cvterm_id": "36915", "query": "KSLSATLISALLAFSAPGFSAA---DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "+SL   L   LL  S   F+AA     +A +V+ TI PLM +Q IPGMAVA+  +GKPYYF +G ADI   +PVT  TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y PEL   QW+GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYANSSIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA+GY+  KPV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "QSLCCAL---LLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQ", "sequence_from_broadstreet": "MAAQSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQVQEKTLRQGIEIAQARYWHIGDMYQGLGWEMLNWPVNADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRI", "dna_sequence_from_broadstreet": "ATGGCTGCACAATCGTTATGCTGCGCGTTGCTGCTGACAGCCTCTTTCTCTACGTTTGCCGCCGCAAAAACAGAACAACAGATTGCCGATATCGTAAACCGTACCATCACACCGCTGATGCAAGAACAGGCTATTCCGGGTATGGCCGTAGCAATTATCTACCAGGGAAAACCCTATTACTTTACCTGGGGGAAAGCCGATATCGCCAATGACCGCCCCGTCACCCGGCAAACGCTGTTTGAGCTTGGATCGGTAAGTAAGACGTTTAACGGTGTGCTGGGCGGCGATGCTATCGCCCGTGGTGAAATTAAGCTCAGCGATCCGGTCACCCAATACTGGCCCGAATTAACTGGCAAACAATGGCAGGGTATCAGCCTGCTGCACCTGGCCACCTATACGGCGGGTGGTCTGCCGCTTCAGGTACCTGACGACGTTACAGATAAAGCGGCATTACTGCGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGTGCTAAACGCCTGTATGCTAACTCCAGTATTGGTCTGTTTGGCGCACTGGCGGTGAAACCTTCAGGAATGGGCTATGAAGAGGCGATGACCAAACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCACAGAGCGAACAAAAGGATTATGCCTGGGGTTATCGCGAAGGGAAGCCCGTACACGTATCTCCGGGCCAGCTTGATGCCGAAGCCTACGGGGTGAAATCCAGCCTTGTCGATATGACTCGTTGGATTCAGGCCAACATGGACGCCAGCCAGGTGCAGGAGAAAACGCTCCGACAGGGAATTGAAATTGCGCAGGCTCGTTACTGGCATATTGGCGATATGTACCAGGGATTAGGTTGGGAGATGCTGAACTGGCCGGTGAATGCCGACTCGATAATCAACGGTAGCGACAGTAAAGTCGCACTAGCGGCGCTTCCCGCCGTTGAGGTCAATCCGCCCGCCCCTGCAGTGAAAGCCTCATGGGTGCACAAAACCGGCTCCACTGGCGGATTTGGCAGCTACGTTGCGTTCGTTCCGGAAAAAAATCTCGGCATCGTGATGCTGGCAAACAAAAGCTACCCAAACCCTGCTCGCGTCGAGGCCGCCTGGCGCATCTAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 59.16}, "gnl|BL_ORD_ID|1395|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-27", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1484", "ARO_accession": "3001847", "ARO_name": "ACT-27", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.71336e-105, "max_identities": 151, "bit_score": 310.842, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCAGAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|1190|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1265", "ARO_accession": "3002167", "ARO_name": "MIR-4", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.93726e-105, "max_identities": 153, "bit_score": 309.301, "cvterm_id": "35914", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP F     +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAPMFE--KQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMFEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTTCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCACGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTAGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.4}, "gnl|BL_ORD_ID|621|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-36", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "663", "ARO_accession": "3003171", "ARO_name": "ACT-36", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.4106e-104, "max_identities": 152, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +TI PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGALT   +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALTVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALTVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGATTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGACGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCTGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.72}, "gnl|BL_ORD_ID|1044|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1114", "ARO_accession": "3001838", "ARO_name": "ACT-17", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.45734e-104, "max_identities": 146, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGATGGTAAAGCGGTGCGTGTTTCGCCGGGTATGCTAGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1966|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-33", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2135", "ARO_accession": "3001853", "ARO_name": "ACT-33", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.67844e-104, "max_identities": 146, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTAGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCACATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1798|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1904", "ARO_accession": "3001852", "ARO_name": "ACT-32", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.81108e-104, "max_identities": 146, "bit_score": 308.531, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|5|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-35", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "9", "ARO_accession": "3001855", "ARO_name": "ACT-35", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.99713e-104, "max_identities": 146, "bit_score": 308.145, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYYILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTAGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTGTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACTATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1853|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1959", "ARO_accession": "3001830", "ARO_name": "ACT-7", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.08429e-104, "max_identities": 145, "bit_score": 307.76, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "M+KSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MRKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAGAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTAGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCACATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.72}, "gnl|BL_ORD_ID|1362|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1451", "ARO_accession": "3003173", "ARO_name": "MIR-17", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.15204e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVTSAAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAGTAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.02}, "gnl|BL_ORD_ID|1784|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1888", "ARO_accession": "3002175", "ARO_name": "MIR-10", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.25648e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|595|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "638", "ARO_accession": "3001827", "ARO_name": "ACT-16", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.33127e-104, "max_identities": 146, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILEAL", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|370|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "399", "ARO_accession": "3002181", "ARO_name": "MIR-16", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.47584e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACATGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCTCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.02}, "gnl|BL_ORD_ID|208|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "224", "ARO_accession": "3002168", "ARO_name": "MIR-2", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.51381e-104, "max_identities": 152, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAACACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|658|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "700", "ARO_accession": "3001851", "ARO_name": "ACT-31", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.7505e-104, "max_identities": 146, "bit_score": 307.76, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACAGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTTCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTACCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|401|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-25", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "433", "ARO_accession": "3001845", "ARO_name": "ACT-25", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.00314e-104, "max_identities": 146, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILKALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACAGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCATTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACTGGCGGATTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCAAGGCGCTTCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1471|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1565", "ARO_accession": "3001839", "ARO_name": "ACT-18", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.22662e-104, "max_identities": 151, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +TI PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGATTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTATACGTTTGGCAAAGCCGATATCGCGGCTAATAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGGGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|2450|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3557", "ARO_accession": "3004745", "ARO_name": "MIR-23", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.61042e-104, "max_identities": 152, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQASSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTTCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTTAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGTGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|627|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "669", "ARO_accession": "3002177", "ARO_name": "MIR-12", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.92098e-104, "max_identities": 152, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEVALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAGTAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACATGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|1772|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1875", "ARO_accession": "3002176", "ARO_name": "MIR-11", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.13955e-104, "max_identities": 152, "bit_score": 307.375, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGAGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAACAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|1233|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1309", "ARO_accession": "3001841", "ARO_name": "ACT-20", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.60625e-104, "max_identities": 145, "bit_score": 306.99, "cvterm_id": "39098", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKSHYYTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTGGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTCGGTAAAGCCGATGTTGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGTTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.72}, "gnl|BL_ORD_ID|346|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "373", "ARO_accession": "3002169", "ARO_name": "MIR-3", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.1977e-104, "max_identities": 152, "bit_score": 306.99, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCACGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.02}, "gnl|BL_ORD_ID|1449|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1541", "ARO_accession": "3001836", "ARO_name": "ACT-14", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.35581e-104, "max_identities": 150, "bit_score": 306.99, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYLAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCAGATATCGCGGCTAATAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGGGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTAACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACTTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.97}, "gnl|BL_ORD_ID|537|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "576", "ARO_accession": "3002170", "ARO_name": "MIR-5", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.85127e-104, "max_identities": 152, "bit_score": 306.605, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 58.24}, "gnl|BL_ORD_ID|1550|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1645", "ARO_accession": "3001828", "ARO_name": "ACT-23", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.75672e-104, "max_identities": 150, "bit_score": 306.605, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMVPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMVPEKVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTAACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGTGCCGGAGAAGGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.97}, "gnl|BL_ORD_ID|1821|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-24", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1929", "ARO_accession": "3001844", "ARO_name": "ACT-24", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12367e-103, "max_identities": 151, "bit_score": 306.22, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +TI PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTITPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIDGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGATTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTATACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGGGCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGACGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|1545|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1640", "ARO_accession": "3002179", "ARO_name": "MIR-14", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12367e-103, "max_identities": 149, "bit_score": 306.22, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +L+LATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T RI  PL L+HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIHMLELATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRIFKPLNLNHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIHMLELATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRIFKPLNLNHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDSSLRKGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPLVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTTGCCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGCATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCAAACAAACCCGTCACCCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTGGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTCGGCGATCCGGTGACAAAATACTGGCCTGAACTGACGGGCAAGCAGTGGCAGGGCATTCACATGCTGGAGCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGAATCTTTAAGCCGCTCAATCTGAACCATACCTGGATTAACGTTCCGAAAACGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTCCACGTTTCGCCAGGAATGCTGGATGCAGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAGGAAAGGCATTGCCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAAGGGTTAGGTTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGCAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCACCGCTGGTCAACGCGTCCTGGGTCCATAAAACAGGCTCAACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAACAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCTGCCCGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.09}, "gnl|BL_ORD_ID|1161|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1234", "ARO_accession": "3002178", "ARO_name": "MIR-13", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33699e-103, "max_identities": 151, "bit_score": 306.22, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG L+AE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLNAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLNAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTTGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGAACGCAGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTTAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGTGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|1736|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1838", "ARO_accession": "3001824", "ARO_name": "ACT-5", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.44263e-103, "max_identities": 149, "bit_score": 306.22, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMP+EQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YG+K+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYPILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTTGGCAAAGCCGATATCGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCCCTTTGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCATGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAATATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCCTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.6}, "gnl|BL_ORD_ID|906|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "968", "ARO_accession": "3002180", "ARO_name": "MIR-15", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.75419e-103, "max_identities": 151, "bit_score": 305.834, "cvterm_id": "39773", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PL+  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P ", "sequence_from_db": "MTKSLSCALLLSVASAAFAAP--MSEKQLAEVVERTVTPLINAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPD", "sequence_from_broadstreet": "MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLINAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGCGCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATAAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTACACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTTAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGTGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.63}, "gnl|BL_ORD_ID|224|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-30", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "241", "ARO_accession": "3001850", "ARO_name": "ACT-30", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.8123e-103, "max_identities": 146, "bit_score": 305.834, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  L   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GK +Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P +  +A", "sequence_from_db": "MKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMIAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYARGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGLSCSALAAPVSEKQLAEVVANTVTPLMIAQSVPGMAVAVIYQGKSHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYARGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQVGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCCTCTCTTGCTCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGATAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAATCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCAGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAAGGTTGCCGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAAGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTACCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCATGGGTCCATAAAACGGGTTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGGTCGGTATTGTAATGCTCGCGAATAAAAGCTATCCGAATCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.09}, "gnl|BL_ORD_ID|1605|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1702", "ARO_accession": "3002166", "ARO_name": "MIR-1", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.5937e-103, "max_identities": 151, "bit_score": 305.449, "cvterm_id": "35915", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ +A+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTTCGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|891|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "951", "ARO_accession": "3001837", "ARO_name": "ACT-15", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.95483e-103, "max_identities": 145, "bit_score": 305.449, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  +   +     +   +A VV +T+ PLM  Q +PGMAVAV  +GKP+Y+ +G ADI A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  K G  RLYAN+SIGLFGAL    +GMPYEQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKSGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKSGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTTTGCTGCGCCCTGCTGCTCGGCATTTCTTGCTCTGCTCTCGCCACGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCTGTTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGAAAACCGCACTATTACACGTTTGGCAAGGCCGATATCGCGGCGAATAAACCCGTTACGCCTCAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCCACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGTCTGGCACAACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTCAAACCTTCTGGCATGCCCTATGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTGCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGCTATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGTATGCTGGATGCACAAGCCTATGGCGTGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGGTCGAGGGCAGCGACAGTAAGGTAGCGCTGGCGCCGTTGCCCGTGGTAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATACAAGCTATCCGAACCCGGCACGTGTTGAGGCGGCATACCATATCCTCGAGGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.72}, "gnl|BL_ORD_ID|1799|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1905", "ARO_accession": "3001842", "ARO_name": "ACT-21", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.18827e-103, "max_identities": 148, "bit_score": 305.064, "cvterm_id": "39098", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L   LL  S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  +Y P+L   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GMP+EQ +T R+L PL L HT+I VP++ ++ YA+GY++ K VRVSPG LDA++YG+K+  +DM  W   NM P    +A", "sequence_from_db": "MKKSLCCAL---LLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADVAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADVAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYPILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCGGCATCTCTTGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGTCGATTCCAGGCATGGCGGTGGCCGTTATTTATCAGGGTAAACCGCACTATTACACGTTCGGTAAAGCCGATGTTGCGGCCAGCAAACCCGTTACGCCTCAGACTCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGGGTTTTAGGAGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGACGATCCGGTGACCAGATACTGGCCACAGCTGACGGGCAAGCAGTGGCAGGGGATTCGTATGCTGGATCTCGCAACCTACACCGCTGGCGGCCTGCCGCTACAGGTACCGGATGAGGTCACGGATAATGCCGCCCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAACGCCAGTATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCCCTTTGAGCAGGCCATGACGACGCGGGTCCTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATATCGTGACGGTAAAGCGGTGCGCGTTTCGCCGGGAATGCTGGATGCACAAGCCTATGGCATGAAAACCAACGTGCAGGATATGGCGAACTGGGTCATGGCAAATATGGCGCCGGAGAACGTTGCTGATGCCTCACTTAAGCAGGGCATCTCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCCGTGGAGGCCAACACGGTGATCGAGGGCAGCGACAGTAAGGTGGCGCTGGCACCGCTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCCTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.22}, "gnl|BL_ORD_ID|1098|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1164", "ARO_accession": "3002174", "ARO_name": "MIR-9", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.2231e-103, "max_identities": 151, "bit_score": 305.064, "cvterm_id": "36926", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E+AL DP AKY PEL   QW+ I +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVASSAFAAP--MSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQSIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQSIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCGCCAGTTCTGCATTCGCCGCACCGATGTCCGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGAGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGTTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGGTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGTTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCACCGCCGGTCAAGGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTTGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|17|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "22", "ARO_accession": "3001832", "ARO_name": "ACT-10", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.3703e-103, "max_identities": 147, "bit_score": 304.679, "cvterm_id": "36783", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKS+   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPG+AVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QWKGI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MKKSVCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGIAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWKGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPD", "sequence_from_broadstreet": "MMKKSVCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGIAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWKGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKTEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPDSLEDSSLRKGFTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCGTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCTCAGGCCATTCCGGGTATAGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAATAAACCTGTCACCCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGAAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAACGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCGCTTGAGGATAGTTCACTCAGGAAAGGCTTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGTTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACCGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCGTTTATTCCCGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCCAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|70|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-29", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "80", "ARO_accession": "3001849", "ARO_name": "ACT-29", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.45943e-103, "max_identities": 147, "bit_score": 304.294, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "MKKSL   L+  ++    +AP   +   +A +V+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MKKSLCCALLLSTSCSVLAAP--MSEKQLAEMVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPD", "sequence_from_broadstreet": "MMKKSLCCALLLSTSCSVLAAPMSEKQLAEMVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPDSLQDSSLRKGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCTCTTTGCTGCGCCCTGCTGCTCAGCACATCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGATGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTCGCGGCGAATAAACCTGTCACTCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGTATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCCAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAGCTGGGTGATGGTCAATATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAGGAAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGTTGCCTGCGAGAGAAGTGAATCCACCGGCTCCCCCGGTCAATGCGTCCTGGGTCCATAAAACCGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCCGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|238|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-37", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "257", "ARO_accession": "3003172", "ARO_name": "ACT-37", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.12279e-103, "max_identities": 151, "bit_score": 304.294, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKS    L   LLA S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI AK+PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  KY PEL   QW+GI +LDLATYTAGGLPLQVP+ V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L+HT+I VP++  + YA+GY++ K V VSPG LDAE+YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSFCCAL---LLAISGAALAAPVSEKQLAEVVANTVTPLMKAQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVIKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMANMAPENVADA", "sequence_from_broadstreet": "MMKKSFCCALLLAISGAALAAPVSEKQLAEVVANTVTPLMKAQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVIKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEAKTVIEGSDNKVALAPLPVAEVNPPVPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCTTTTGCTGCGCCCTGCTGCTCGCCATCTCTGGCGCTGCTCTCGCCGCGCCAGTATCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAGCCCAGGCTATTCCAGGCATGGCGGTGGCCGTTATCTATCAGGGAAAACCGCACTATTACACGTTTGGCGAAGCCGATATTGCGGCCAAAAAACCCGTTACGCCACAAACCCTGTTCGAGCTAGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCGCTGGATGATCCGGTGATCAAATACTGGCCTGAACTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCAACCTACACCGCGGGCGGCCTGCCGCTACAGGTACCGGAAGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAACACTGGCAACCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAATGCCAGCATCGGACTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCGCTATGAGCAGGCCATGACGAAGCGGGTCTTCAAGCCGCTCAGGCTGAACCATACCTGGATTAACGTTCCGAAAGCGGAAGCGGCGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTCCACGTTTCACCGGGTATGCTGGACGCAGAGGCCTATGGCGTGAAAACTAACGTGCAGGATATGGCGAACTGGGTGATGGCGAACATGGCGCCGGAGAACGTTGCTGATGCCTCACTCAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGTATCGGGTCAATGTATCAGGGCCTGGGCTGGGAAATGCTCAACTGGCCCGTGGAGGCCAAAACAGTGATCGAGGGCAGCGACAATAAGGTGGCACTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGTTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACGGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAATCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCACTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.34}, "gnl|BL_ORD_ID|1794|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1900", "ARO_accession": "3001835", "ARO_name": "ACT-13", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.09987e-102, "max_identities": 147, "bit_score": 303.908, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKP", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVMVNMKPDSLEESSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCAGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACCCCACAAACCTTATTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACCAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTCTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCGCTTGAGGAAAGTTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGGTTGGGCTGGGAAATGCTTAACTGGCCGGTCGATGCAAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACCGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.32}, "gnl|BL_ORD_ID|1689|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1788", "ARO_accession": "3001825", "ARO_name": "ACT-6", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.09987e-102, "max_identities": 147, "bit_score": 303.908, "cvterm_id": "35915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPD", "sequence_from_broadstreet": "MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPDSLQDSSLKEGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCTCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTCGCGGCGAATAAACCCGTCACCCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGTGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCACTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAACTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAAGGAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGATTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAATGCGTCATGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|1071|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MIR-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1136", "ARO_accession": "3002171", "ARO_name": "MIR-6", "ARO_category": {"36197": {"category_aro_accession": "3000058", "category_aro_cvterm_id": "36197", "category_aro_name": "MIR beta-lactamase", "category_aro_description": "MIR beta-lactamases are plasmid-mediated beta-lactamases that confer resistance to oxyimino- and alpha-methoxy beta-lactams", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30862e-102, "max_identities": 151, "bit_score": 303.523, "cvterm_id": "36884", "query": "MKKSLSATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSLS  L+ ++   AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKT TGVLG  ++A+ E+AL DP AKY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY+  K V VSPG LDAE+YGVK+  KDM  W   NM+P", "sequence_from_db": "MTKSLSCALLLSVTSAAFAAP--MSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTSTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKP", "sequence_from_broadstreet": "MMTKSLSCALLLSVTSAAFAAPMSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTSTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGTGCCCTGCTGCTCAGCGTCACCAGCGCTGCATTCGCCGCACCGATGTCCGAAACACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAACGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTAATTTATCAGGGTCAGCCACACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCCGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTCCACCGGCGTACTGGGCGGCGATGCCATTGCCCGGGGTGAAATAGCGCTGGGCGATCCGGTAGCAAAATACTGGCCTGAGCTCACGGGCAAGCAGTGGCAGGGCATTCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTGCCGGATGAGGTCACGGATACCGCTTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCTAACGCCAGCATCGGTCTTTTTGGTGCGCTGGCGGTTAAACCTTCCGGCATGAGCTATGAGCAGGCCATGACGACGCGGGTCTTTAAACCCCTCAAGCTGGACCATACCTGGATTAACGTCCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGTGAGGGTAAAGCGGTCCACGTTTCGCCAGGGATGCTGGACGCGGAAGCCTATGGCGTAAAAACTAACGTGAAGGATATGGCGAGCTGGCTGATAGCCAACATGAAGCCGGATTCTCTTCAGGCTCCCTCACTCAAGCAAGGCATTGCTCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCTATGTATCAGGGGCTGGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTCGTCGGAGGCAGTGATAACAAGGTGGCGCTGGCACCATTGCCCGTGGCAGAAGTGAATCCACCCGCGCCGCCGGTCAAAGCCTCCTGGGTCCATAAAACAGGCTCGACGGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.85}, "gnl|BL_ORD_ID|625|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "667", "ARO_accession": "3001821", "ARO_name": "ACT-1", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.32708e-102, "max_identities": 146, "bit_score": 303.138, "cvterm_id": "35915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD VK  A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCAAGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCAGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTTGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCAGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.73}, "gnl|BL_ORD_ID|220|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "236", "ARO_accession": "3001840", "ARO_name": "ACT-19", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.05303e-102, "max_identities": 149, "bit_score": 302.753, "cvterm_id": "36884", "query": "MKKSLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKS    L   LLA S    +A      +A VV +T+ PLM  Q IPGMAVAV  +GKP+Y+ +G ADI AK+PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  K+ PEL   QW+GI +LDLATYTAGGLPLQVP+ V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L+HT+I VP++  + YA+GY++ K V +SPG LDAE+YGVK+  +DM  W   NM P    +A", "sequence_from_db": "MKKSFCCAL---LLAISGSALAAPVSEKQLAEVVANTVTPLMKTQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTKFWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHISPGMLDAEAYGVKTNVQDMANWVMANMAPENIADA", "sequence_from_broadstreet": "MMKKSFCCALLLAISGSALAAPVSEKQLAEVVANTVTPLMKTQAIPGMAVAVIYQGKPHYYTFGEADIAAKKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTKFWPELTGKQWQGIRMLDLATYTAGGLPLQVPEEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMRYEQAMTKRVFKPLRLNHTWINVPKAEAAHYAWGYRDGKAVHISPGMLDAEAYGVKTNVQDMANWVMANMAPENIADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEAKMVIEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYHILDALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCTTTTGCTGCGCCCTGCTGCTCGCCATCTCTGGCTCTGCTCTCGCCGCGCCAGTGTCAGAAAAACAGCTGGCGGAGGTGGTCGCGAATACGGTTACCCCGCTGATGAAAACCCAGGCTATTCCAGGCATGGCGGTGGCCGTTATCTATCAGGGAAAACCGCACTATTACACGTTTGGCGAAGCCGATATTGCGGCCAAAAAACCTGTTACGCCACAGACCCTGTTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTTTTAGGTGGGGATGCCATTGCTCGCGGTGAAATTTCCCTGGACGATCCGGTGACCAAATTCTGGCCTGAACTGACGGGCAAGCAGTGGCAGGGTATTCGTATGCTGGATCTCGCAACCTACACCGCGGGCGGCCTGCCGCTACAGGTACCGGAAGAGGTCACGGATAACGCCTCCCTGCTGCGCTTTTATCAACACTGGCAACCGCAGTGGAAGCCTGGCACAACGCGTCTTTACGCCAATGCCAGCATCGGACTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGCGCTATGAGCAGGCCATGACGAAGCGGGTCTTCAAGCCGCTCAGGCTGAACCATACCTGGATTAACGTTCCGAAAGCGGAAGCGGCGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTCCACATTTCACCGGGTATGCTGGACGCAGAGGCCTATGGCGTGAAAACTAACGTGCAGGATATGGCGAACTGGGTGATGGCGAACATGGCGCCGGAGAACATTGCTGATGCCTCACTCAAGCAGGGCATCGCGCTGGCGCAGTCGCGCTACTGGCGCATCGGGTCAATGTATCAGGGCCTGGGCTGGGAAATGCTCAACTGGCCCGTGGAGGCCAAAATGGTGATCGAGGGCAGCGACAATAAGGTGGCACTGGCGCCGTTGCCCGTGGCAGAAGTGAATCCACCGGCTCCCCCGGTCAAAGCGTCCTGGGTCCATAAAACAGGCTCTACTGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCGAATAAAAGCTATCCGAATCCGGCACGCGTTGAGGCGGCATACCATATCCTCGACGCACTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.6}, "gnl|BL_ORD_ID|1416|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1506", "ARO_accession": "3001834", "ARO_name": "ACT-12", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.18859e-102, "max_identities": 148, "bit_score": 302.753, "cvterm_id": "36884", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  ++  A +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A  PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+G+ +LDLATYTAGGLPLQVPD V   A LL FYQ WQP   PG  RLYAN+SIGLFGAL    +GM +EQ +T R+L PL L+HT+I VP++ +  YA+GY++ K V VSPG LDAE+YGVK+  KDM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLSTSCAALAAP--LSETQLAKVVERTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDA", "sequence_from_broadstreet": "MMKKSLCCALLLSTSCAALAAPLSETQLAKVVERTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDASLKQGMVLAQSRYWRTGSMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKSYPNPARVEAAYRILSALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTGTGCTGCGCCCTGCTGCTCAGCACCTCCTGCGCTGCATTAGCCGCACCTCTGTCAGAAACACAGCTGGCGAAGGTCGTGGAACGTACCGTTACGCCCCTGATGAAAGCGCAGTCTATTCCGGGTATGGCGGTCGCCGTGATCTATCAGGGCCAGCCGCACTACTTCACCTTCGGCAAGGCCGATGTCGCCGCGAACACACCCGTCACTGCACAAACGCTGTTTGAGCTGGGCTCAATCAGCAAAACCTTCACCGGCGTTCTGGGTGGCGATGCTATTGCTCGCGGTGAAATTTCGCTGGGCGATCCGGTGACCAAATACTGGCCTGAACTGACCGGCAAACAGTGGCAGGGCGTTCGCATGCTGGACCTGGCAACCTATACTGCCGGTGGCCTGCCGTTACAGGTGCCCGATGAGGTTACCGATAATGCCTCGCTGCTGCGTTTTTACCAGTCCTGGCAACCACAGTGGGCGCCAGGCACCACGCGTCTTTATGCGAATGCCAGCATCGGTCTGTTTGGGGCTCTGGCAGTGAAACCTTCTGGCATGCGCTTTGAGCAGGCGATGACGGAGCGGGTCCTGAAGCCGCTTAACCTGAACCATACGTGGATTAACGTTCCGAAGGCAGAAGAACAGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTTCACGTTTCGCCGGGCATGCTCGATGCCGAAGCATATGGCGTGAAAACCAACGTGAAGGATATGGCGAGCTGGGTGGTGGCTAACATGGCCCCCGATGGGGTACAGGATGCCTCACTGAAGCAGGGCATGGTGCTTGCACAGTCTCGCTACTGGCGCACAGGCTCGATGTACCAGGGCCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTGGTGGAGGGCAGCGACAACAAGGTAGCGCTTGCACCGTTGCCCGTGGCAGAAGTGAACCCTCCGGCTCCACCGGTAAAAGCGTCATGGGTACATAAAACAGGCTCGACGGGCGGATTTGGCAGCTACGTGGCATTTATCCCTGAGAAGGAACTCGGCATCGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCACGCGTGGAAGCGGCATACCGTATTCTGAGCGCTCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.43}, "gnl|BL_ORD_ID|1406|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1495", "ARO_accession": "3001829", "ARO_name": "ACT-4", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.75704e-102, "max_identities": 146, "bit_score": 302.368, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNASLLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNASLLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCACCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGCCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACCCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTTACCGGCGTACTGGGTGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACGGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGCGGTCTGCCGTTACAGGTACCGGATGAGGTCGCGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGTACCACGCGTCTTTACGCCAATACCAGCATCGGCCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAACAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGCATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGCAAGGCATTGCCCTGGCGCAGTCTCGCTACTGGCGCGTAGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGCTGCCCGCAAGAGAAGTGAATCCTCCGGCGCCTCCGGTCAACGCGTCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCCTTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCCAACCCAGCACGCGTTGAGGCGGCTTACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.73}, "gnl|BL_ORD_ID|2135|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3313", "ARO_accession": "3001831", "ARO_name": "ACT-8", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.18325e-102, "max_identities": 146, "bit_score": 302.368, "cvterm_id": "35914", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ +S YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEESHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMVNMKP", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEESHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMANWVMVNMKPDSLQDSSLRKGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCTCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAATAAACCTGTCACCCCACAAACCTTATTCGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTACTGGGCGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACCAAATACTGGCCTGAACTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACTACGCGTCTTTACGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCCAAAGCGGAAGAGTCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGCATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAACTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAGGAAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTAGGTGCCATGTATCAGGGTTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAATGCGTCATGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCGTTTATTCCCGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.94}, "gnl|BL_ORD_ID|372|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "401", "ARO_accession": "3001843", "ARO_name": "ACT-22", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.60185e-102, "max_identities": 148, "bit_score": 301.597, "cvterm_id": "36884", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "MKKSL   L+  ++  A +AP   +   +A VV  T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A  PVT  TLFELGS+SKTFTGVLG  ++A+ E++L+DP  KY PEL   QW+G+ +LDLATYTAGGLPLQVPD V   A LL FYQ WQP   PG  RLYAN+SIGLFGAL    +GM +EQ +T R+L PL L+HT+I VP++ +  YA+GY++ K V VSPG LDAE+YGVK+  KDM  W   NM P    +A", "sequence_from_db": "MKKSLCCALLLSTSCAALAAP--MSETQLAKVVARTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLSDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDA", "sequence_from_broadstreet": "MMKKSLCCALLLSTSCAALAAPMSETQLAKVVARTVTPLMKAQSIPGMAVAVIYQGQPHYFTFGKADVAANTPVTAQTLFELGSISKTFTGVLGGDAIARGEISLSDPVTKYWPELTGKQWQGVRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQSWQPQWAPGTTRLYANASIGLFGALAVKPSGMRFEQAMTERVLKPLNLNHTWINVPKAEEQHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMASWVVANMAPDGVQDASLKQGMALAQSRYWRTGSMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKKLGIVMLANKSYPNPARVEAAYRILSALQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCCCTGTGCTGCGCCCTGCTGCTCAGCACCTCCTGCGCTGCATTAGCCGCACCTATGTCAGAAACACAGCTGGCGAAGGTCGTGGCACGTACCGTTACGCCCCTGATGAAAGCGCAGTCTATTCCGGGTATGGCGGTCGCCGTGATCTATCAGGGCCAGCCGCACTACTTCACCTTCGGCAAGGCCGATGTCGCAGCGAACACACCCGTCACTGCACAAACGCTGTTTGAGCTGGGCTCAATCAGCAAAACCTTCACCGGCGTTCTGGGTGGCGATGCTATTGCTCGCGGTGAAATTTCGCTGAGCGATCCGGTGACCAAATACTGGCCTGAGCTGACCGGCAAACAGTGGCAGGGCGTTCGCATGCTGGACCTGGCAACCTATACTGCCGGTGGCCTGCCGTTACAGGTGCCCGATGAGGTTACCGATAATGCCTCGCTGCTGCGTTTTTACCAGTCCTGGCAACCACAGTGGGCGCCAGGCACCACGCGTCTTTATGCGAATGCCAGCATCGGTCTGTTTGGGGCTCTGGCGGTGAAACCTTCTGGCATGCGCTTTGAGCAGGCGATGACAGAGCGGGTCCTGAAGCCGCTTAACCTGAACCATACGTGGATTAACGTTCCGAAGGCAGAAGAACAGCATTACGCCTGGGGTTATCGTGACGGTAAAGCGGTTCACGTTTCGCCGGGCATGCTCGATGCCGAAGCGTATGGCGTGAAAACCAACGTGAAGGATATGGCGAGCTGGGTAGTGGCTAACATGGCCCCCGATGGCGTACAGGATGCCTCACTGAAGCAGGGCATGGCGCTTGCACAGTCTCGCTACTGGCGCACAGGCTCGATGTACCAGGGCCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTGGTGGAGGGCAGCGACAACAAAGTAGCGCTTGCGCCGTTGCCCGTGGCAGAAGTGAACCCTCCTGCTCCACCGGTAAAAGCGTCATGGGTACATAAAACAGGCTCGACGGGCGGATTTGGCAGCTACGTGGCATTTATCCCTGAGAAGAAACTCGGCATTGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCGCGCGTGGAAGCGGCATACCGTATTCTGAGCGCTCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.43}, "gnl|BL_ORD_ID|2109|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-38", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3311", "ARO_accession": "3003655", "ARO_name": "ACT-38", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.38235e-102, "max_identities": 147, "bit_score": 301.597, "cvterm_id": "36915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    +AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A  PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  KDM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLAAP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANNPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWLGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITMRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPD", "sequence_from_broadstreet": "MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANNPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWLGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITMRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPDSLQDSSLKEGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTGCCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGTACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGTAAAGCCGATGTTGCGGCGAACAACCCTGTCACCCCACAAACCTTATTCGAGCTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGCGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCTGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGTGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGCTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTATGCCAACGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGATGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACCTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAGGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGAAGGATATGGCAAACTGGGTGATGGTCAACATGAAGCCGGACTCGCTTCAGGATAGTTCACTCAAGGAAGGCATTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGATTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCGCTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAATGCGTCATGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGCATTGTGATGCTGGCGAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATCCTCGACGCGCTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.11}, "gnl|BL_ORD_ID|2700|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMH-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "3576", "ARO_accession": "3004777", "ARO_name": "CMH-1", "ARO_category": {"42891": {"category_aro_accession": "3004776", "category_aro_cvterm_id": "42891", "category_aro_name": "CMH beta-lactamase", "category_aro_description": "CMH is a class C beta-lactamase gene family belonging to Enterobacter cloacae.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.94671e-102, "max_identities": 151, "bit_score": 301.597, "cvterm_id": "36884", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSLS  L+   A  AF+AP   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGSVSKTFTGVLG  ++A+KE++L DP  KY PEL   QW+GI LLDLATYTAGGLPLQVPD V   A LL FYQ WQP   PG  RLYAN+SIGLFG+L    +GM +EQ +  R+  PL L+HT+I VP + +  YA+GY+  K V VSPG LDAE+YGVKS  KDM  W   NM P ", "sequence_from_db": "MTKSLSCALLLSVACSAFAAP--MSEKQLADVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSVSKTFTGVLGGDAIARKEISLADPVTKYWPELTGKQWQGIRLLDLATYTAGGLPLQVPDDVTDNASLLRFYQSWQPKWAPGTTRLYANTSIGLFGSLAVKPSGMCFEQAMAERVFKPLKLNHTWINVPHAEEPHYAWGYREGKAVHVSPGMLDAEAYGVKSNVKDMASWVMANMAPE", "sequence_from_broadstreet": "MMTKSLSCALLLSVACSAFAAPMSEKQLADVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSVSKTFTGVLGGDAIARKEISLADPVTKYWPELTGKQWQGIRLLDLATYTAGGLPLQVPDDVTDNASLLRFYQSWQPKWAPGTTRLYANTSIGLFGSLAVKPSGMCFEQAMAERVFKPLKLNHTWINVPHAEEPHYAWGYREGKAVHVSPGMLDAEAYGVKSNVKDMASWVMANMAPETLPQSTLQQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVDGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPVRVETAYRILDALQ", "dna_sequence_from_broadstreet": "ATGATGACAAAATCCCTAAGCTGCGCGCTGCTGCTCAGCGTTGCCTGCTCTGCTTTTGCCGCGCCGATGTCAGAAAAACAGCTGGCTGACGTCGTGGAACGTACCGTTACGCCTCTGATGAAGGCGCAGGCCATACCCGGAATGGCCGTGGCCGTCATTTATCAGGGCCAGCCACACTATTTTACTTTCGGTAAAGCAGACGTCGCGGCGAATAAGCCCGTCACGCCGCAAACCTTATTTGAGCTGGGCTCCGTCAGCAAAACCTTCACCGGCGTGCTGGGTGGCGATGCCATTGCCCGCAAAGAGATTTCGCTGGCCGACCCGGTCACGAAATATTGGCCTGAATTGACGGGCAAGCAGTGGCAAGGCATTCGCCTGCTAGACCTGGCAACCTATACCGCAGGCGGATTGCCGTTGCAGGTACCGGATGATGTCACCGATAACGCCTCTCTGCTGCGTTTCTACCAGTCCTGGCAGCCAAAGTGGGCCCCGGGTACCACGCGTCTGTACGCCAACACCAGCATCGGTTTGTTTGGCTCACTGGCCGTTAAACCGTCCGGCATGTGCTTCGAGCAGGCCATGGCGGAGCGGGTCTTTAAGCCCCTGAAACTCAACCATACGTGGATAAACGTTCCACACGCTGAAGAACCGCACTACGCATGGGGTTATCGTGAGGGAAAAGCGGTCCACGTTTCGCCTGGTATGCTGGATGCAGAAGCCTATGGCGTGAAATCTAACGTCAAAGATATGGCGAGTTGGGTGATGGCCAATATGGCACCTGAGACACTCCCGCAGTCCACTCTGCAGCAGGGTATTGCGCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAAGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGATGCCAAAACCGTGGTGGATGGCAGCGATAATAAGGTCGCACTGGCGCCGTTGCCGGTCGCAGAAGTGAATCCTCCGGCTCCGCCAGTAAAAGCCTCCTGGGTGCATAAAACGGGCTCTACGGGTGGGTTTGGCAGCTACGTGGCGTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCAAATAAAAGCTATCCGAACCCGGTACGGGTGGAAACGGCTTACCGTATCCTCGACGCGCTACAGTAA", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 57.63}, "gnl|BL_ORD_ID|2582|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CFE-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2901", "ARO_accession": "3004464", "ARO_name": "CFE-2", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12384e-101, "max_identities": 149, "bit_score": 301.212, "cvterm_id": "36915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "MKKS+   L+  ++L  F+A        +A +V+ TI PLM +Q IPGM  A+  +GKPYYF +G ADI   +PVT  TLFELGSVSKTF GVLG  ++A+ E+ L+DP  +Y P+L   QW GI+LL LATYTAGGLPLQVPD V  +A LL FYQ WQP   PG  RLYAN SIGLFGAL    +GM YE+ +T R+L PL L+HT+ITVP+S Q  YA GY+  +PV VSPGQLDAE+YGVKS+  DM RW + NM+ S+", "sequence_from_db": "MKKSICCALLVTASLSTFAAD--KTEQQIADIVNRTITPLMQEQAIPGMRFAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPKLTGKQWLGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANPSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYALGYREGRPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQ", "sequence_from_broadstreet": "MMKKSICCALLVTASLSTFAADKTEQQIADIVNRTITPLMQEQAIPGMRFAIIYQGKPYYFTWGKADIANDRPVTRQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTQYWPKLTGKQWLGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANPSIGLFGALAVKPSGMGYEEAMTKRVLQPLKLAHTWITVPQSEQKDYALGYREGRPVHVSPGQLDAEAYGVKSSLVDMTRWIQANMDASQVQEKTLRQGIEIAQARYWHIGDMYQGLGWEMVNWPVNADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGTSGGFGTYVALVPEKNLVGMMLANKSYPKPARVEAAWRILEKLQ", "dna_sequence_from_broadstreet": "ATGATGAAAAAATCGATTTGCTGCGCGTTGCTGGTCACAGCCTCTCTGTCAACGTTTGCCGCCGACAAAACAGAACAACAGATTGCCGATATCGTAAACCGTACCATCACACCGCTGATGCAAGAACAGGCTATTCCGGGTATGCGCTTCGCAATTATCTACCAGGGAAAACCCTATTACTTTACCTGGGGGAAAGCCGATATCGCCAATGACCGCCCCGTCACCCGGCAAACGCTGTTTGAGCTTGGATCGGTAAGTAAGACGTTTAACGGTGTGCTGGGCGGCGATGCTATCGCCCGTGGTGAAATTAAGCTCAGCGATCCGGTCACCCAATACTGGCCCAAATTAACTGGCAAACAATGGCTGGGTATCAGCCTGCTGCATCTGGCCACCTATACGGCGGGTGGCCTGCCGCTTCAGGTACCTGACGACGTTACAGATAAAGCGGCATTACTGCGCTTTTATCAAAACTGGCAGCCGCAATGGGCCCCGGGCGCTAAACGCCTGTATGCTAACCCAAGTATTGGTCTGTTTGGCGCACTGGCGGTGAAACCTTCAGGAATGGGCTATGAAGAGGCGATGACCAAACGCGTCCTGCAACCATTAAAACTGGCGCATACCTGGATTACGGTTCCACAGAGCGAACAAAAGGATTATGCCTTGGGTTATCGCGAAGGAAGGCCCGTGCACGTATCTCCGGGCCAGCTTGATGCCGAAGCCTACGGGGTGAAATCCAGCCTTGTCGATATGACTCGCTGGATTCAGGCCAACATGGACGCCAGCCAGGTGCAGGAGAAAACGCTCCGACAGGGAATTGAAATTGCGCAGGCTCGTTACTGGCATATTGGCGATATGTACCAGGGATTAGGTTGGGAGATGGTCAACTGGCCGGTGAATGCCGACTCGATAATCAACGGTAGCGACAGTAAAGTCGCGTTAGCGGCGCTTCCCGCCGTTGAGGTCAATCCGCCCGCCCCTGCAGTGAAAGCCTCATGGGTGCACAAAACCGGCACTTCCGGCGGATTTGGCACGTACGTTGCGTTGGTTCCGGAAAAAAATCTCGTCGGCATGATGCTGGCAAACAAAAGCTACCCAAAGCCTGCTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAATTGCAGTAA", "partial": "0", "query_start": 1846, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 56.65}, "gnl|BL_ORD_ID|492|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "526", "ARO_accession": "3001822", "ARO_name": "ACT-2", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.67957e-101, "max_identities": 145, "bit_score": 300.827, "cvterm_id": "36926", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K V VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAACGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGCGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGGTACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTGGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCGGCGCCCCCGGTCAACGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 55.34}, "gnl|BL_ORD_ID|1485|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1581", "ARO_accession": "3001823", "ARO_name": "ACT-3", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.53748e-101, "max_identities": 144, "bit_score": 300.442, "cvterm_id": "35915", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "M KSL   L+  ++    + P   +   +A VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM YEQ +T R+  PL L HT+I VP++ ++ YA+GY++ K + VSPG LDAE+YGVK+  +DM  W  +NM+P ", "sequence_from_db": "MTKSLCCALLLSTSCSVLATP--MSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPD", "sequence_from_broadstreet": "MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGATGATGACTAAATCCCTTTGCTGCGCCCTGCTGCTCAGCACCTCCTGCTCGGTATTGGCTACCCCGATGTCAGAAAAACAGCTGGCTGAGGTGGTGGAGCGGACCGTTACGCCGCTGATGAAAGCGCAGGCCATTCCGGGTATGGCGGTGGCGGTGATTTATGAGGGTCAGCCGCACTACTTCACCTTCGGTAAAGCCGATGTTGCGGCGAACAAACCTGTCACTCCACAAACCTTGTTCGAACTGGGTTCTATAAGTAAAACCTTCACCGGCGTACTCGGTGGCGATGCCATTGCTCGGGGTGAAATATCGCTGGGCGATCCGGTGACAAAATACTGGCCTGAGCTGACAGGCAAGCAGTGGCAGGGGATCCGCATGCTGGATCTGGCAACCTATACCGCAGGAGGTTTGCCGTTACAGGTACCGGATGAGGTCACGGATAACGCCTCTCTGTTGCGCTTTTATCAAAACTGGCAGCCGCAGTGGAAGCCGGGCACCACGCGTCTTTACGCCAATGCCAGCATCGGTCTTTTTGGCGCGCTGGCGGTCAAACCTTCCGGCATGAGCTATGAGCAGGCCATAACGACGCGGGTCTTTAAGCCGCTCAAGCTGGACCATACGTGGATTAACGTTCCGAAAGCGGAAGAGGCGCATTACGCCTGGGGATACCGCGACGGTAAAGCGATACACGTTTCGCCAGGAATGCTGGACGCTGAAGCCTATGGCGTAAAAACCAACGTGCAGGATATGGCAAGCTGGGTGATGGTCAACATGAAGCCGGACTCCCTTCAGGATAATTCACTCAGGAAAGGCCTTACCCTGGCGCAGTCTCGCTACTGGCGCGTGGGGGCCATGTATCAGGGGTTAGGCTGGGAAATGCTTAACTGGCCGGTCGATGCCAAAACCGTGGTTGAAGGTAGCGACAATAAGGTTGCACTGGCACCGCTGCCTGCGAGAGAAGTGAATCCACCAGCGCCCCCGGTCAATGCATCCTGGGTCCATAAAACAGGCTCTACCGGCGGGTTTGGCAGCTACGTGGCATTTATTCCTGAAAAGCAGCTCGGTATTGTGATGCTGGCAAATAAAAGCTATCCGAACCCGGCACGCGTTGAGGCGGCATACCGTATTTTGAGCGCGCTGTAG", "partial": "0", "query_start": 1846, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.96}, "gnl|BL_ORD_ID|2508|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "BUT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2846", "ARO_accession": "3004294", "ARO_name": "BUT-1", "ARO_category": {"41459": {"category_aro_accession": "3004293", "category_aro_cvterm_id": "41459", "category_aro_name": "BUT beta-lactamase", "category_aro_description": "A class C beta-lactamase family of chromosome-encoded antibiotic resistance genes originally described from Buttiauxella spp.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.83006e-101, "max_identities": 150, "bit_score": 300.442, "cvterm_id": "41461", "query": "MKKSLSATLI--SALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTS", "match": "MKK+L   L+  ++  AF+A    +   +   V+ T+KP++  Q IPGMAVAV  +GKP+YF YG ADI   QPVT  T+FELGSVSKTFTGVLG   VA+ E+ L+DPA KY PEL   QW+GITLLDLATYTAGGLPLQVPD V ++A LL FYQ WQP   PG  R YANSSIGLFGAL    +GM +   +  R+L PL L HT++TVP S ++ YA+GY++ K + V PG LD E+YGVKS  +DM  W + NM P +      L   LE++ S", "sequence_from_db": "MKKTLCCALVLSASFSAFAAQKTLSDKQLEEAVNQTLKPMITAQAIPGMAVAVIYQGKPHYFTYGVADIAKNQPVTTQTIFELGSVSKTFTGVLGGDIVARGEVKLSDPAMKYWPELTGKQWQGITLLDLATYTAGGLPLQVPDEVDNQAALLKFYQNWQPDWAPGTRRQYANSSIGLFGALAVKPSGMTFNDAMRQRVLQPLNLKHTWLTVPASEENHYAWGYRDGKAMHVGPGMLDTEAYGVKSTIEDMASWVQYNMNPQQVKQP-TLQKGLEIAQS", "sequence_from_broadstreet": "MCRTLCHVTYGRFSMMKKTLCCALVLSASFSAFAAQKTLSDKQLEEAVNQTLKPMITAQAIPGMAVAVIYQGKPHYFTYGVADIAKNQPVTTQTIFELGSVSKTFTGVLGGDIVARGEVKLSDPAMKYWPELTGKQWQGITLLDLATYTAGGLPLQVPDEVDNQAALLKFYQNWQPDWAPGTRRQYANSSIGLFGALAVKPSGMTFNDAMRQRVLQPLNLKHTWLTVPASEENHYAWGYRDGKAMHVGPGMLDTEAYGVKSTIEDMASWVQYNMNPQQVKQPTLQKGLEIAQSRYWRSGSMYQGLGWEMLNWPVAAATVINGSDNKVALAASPVTAIEPPVAPVKASLVHKTGSTNGFGAYVAFIPEKQIGIVMLANKMYPNTERVKAANTLLNTLQ", "dna_sequence_from_broadstreet": "ATGTGCCGGACCCTCTGTCATGTTACTTATGGAAGATTTTCAATGATGAAAAAAACACTCTGCTGCGCGCTGGTTCTGAGCGCCTCTTTCTCCGCCTTTGCTGCACAAAAAACATTGAGTGACAAACAGTTAGAAGAGGCTGTCAATCAAACGCTTAAACCGATGATTACAGCCCAGGCCATTCCCGGCATGGCGGTGGCGGTGATTTATCAGGGCAAGCCGCACTACTTTACCTACGGCGTGGCCGACATCGCGAAAAATCAGCCGGTGACGACACAGACGATTTTTGAGCTGGGCTCCGTGAGTAAAACTTTCACCGGCGTGCTGGGCGGCGATATCGTGGCGCGCGGGGAAGTGAAGCTGAGTGACCCGGCGATGAAATACTGGCCAGAACTGACGGGCAAGCAGTGGCAGGGCATCACGTTGCTGGATCTGGCGACCTACACCGCCGGCGGCTTGCCGTTGCAGGTGCCGGATGAGGTCGATAATCAGGCCGCGCTGCTGAAGTTTTACCAGAACTGGCAGCCGGACTGGGCGCCGGGAACCCGTCGTCAGTACGCCAACTCGAGCATTGGCCTGTTTGGTGCGTTGGCAGTGAAACCGTCCGGGATGACGTTTAACGATGCGATGCGCCAGCGCGTTCTGCAACCGCTGAACCTGAAACATACCTGGCTCACCGTTCCGGCCAGTGAAGAAAATCATTACGCCTGGGGCTATCGTGACGGCAAAGCCATGCACGTCGGGCCGGGCATGCTGGATACCGAAGCCTACGGTGTCAAATCCACCATCGAAGATATGGCGAGCTGGGTGCAATACAACATGAACCCGCAGCAGGTGAAACAGCCGACGCTGCAAAAAGGGCTGGAGATTGCGCAGTCGCGCTACTGGCGCAGCGGCAGTATGTATCAGGGCTTAGGCTGGGAAATGCTGAACTGGCCGGTTGCGGCGGCGACCGTCATTAACGGCAGCGATAACAAAGTGGCGCTGGCGGCTTCGCCCGTGACGGCCATTGAACCGCCGGTTGCGCCGGTGAAAGCTTCTCTGGTGCATAAAACCGGGTCGACCAACGGCTTCGGCGCGTACGTGGCGTTCATTCCTGAAAAACAAATCGGCATCGTGATGCTGGCTAACAAAATGTATCCGAATACCGAGCGGGTTAAAGCGGCAAATACTCTTCTCAACACGCTGCAATAA", "partial": "0", "query_start": 1846, "query_end": 2676, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 53.76}, "gnl|BL_ORD_ID|1603|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-28", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1700", "ARO_accession": "3001848", "ARO_name": "ACT-28", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.76977e-99, "max_identities": 142, "bit_score": 295.819, "cvterm_id": "36884", "query": "SATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "+ +L  ALL  ++    AA      ++ VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V   A LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM +EQ +T R+  PL L HT+I VP+  ++ YA+GY++ K + VSPG LDAE+YGVK+  +DM  W + NM P ", "sequence_from_db": "TKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQHWQPQWKPGATRLYANASIGLFGALAVKPSGMSFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPD", "sequence_from_broadstreet": "MKTKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQHWQPQWKPGATRLYANASIGLFGALAVKPSGMSFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPDALPDSTLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKSYPNPARVEAAYRILSALQ", "dna_sequence_from_broadstreet": "ATGAAGACAAAATCCCTTTGCTGTGCCCTGCTGCTCAGCACCTCCTGCTCTGTTCTCGCCGCGCCGATGTCAGAGAAACAGCTGTCTGACGTGGTGGAACGTACCGTTACCCCCCTGATGAAAGCGCAAGCCATTCCGGGCATGGCGGTAGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGAAAGGCCGATGTTGCGGCGAACAAACCTGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTATTAGGTGGCGATGCGATTGCGCGCGGAGAAATATCGCTGGGCGACCCCGTGACAAAGTACTGGCCCGAGCTAACAGGCAAGCAGTGGCAGGGTATTCGCATGTTGGATCTGGCGACCTACACCGCGGGTGGCCTGCCGCTACAGGTGCCGGATGAGGTCACGGATAACGCCTCCCTGCTGCGTTTCTATCAACACTGGCAACCGCAGTGGAAACCAGGCGCAACGCGTCTTTATGCGAACGCCAGCATCGGGCTTTTTGGCGCCCTCGCGGTTAAACCCTCCGGCATGAGCTTTGAACAGGCCATGACGAAGCGGGTCTTCAAGCCACTCAAACTGGACCATACATGGATTAACGTTCCGAAAGAAGAAGAGGCGCATTACGCCTGGGGATACCGTGATGGTAAAGCAATCCACGTTTCACCGGGAATGCTGGATGCCGAAGCGTATGGTGTCAAAACCAACATCCAGGATATGGCGAGCTGGCTGAAGGCCAACATGAACCCTGACGCCCTTCCGGATTCAACGTTGAAACAGGGTATTGCCCTGGCACAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTCGTGGAGGGCAGCGATAACAAGGTGGCTCTTGCACCGTTACCGGTGGCAGAAGTGAACCCTCCAGCTCCGCCAGTAAAAGCATCATGGGTACATAAAACAGGCTCGACGGGTGGATTCGGCAGCTATGTCGCATTTATTCCTGAAAAGGAACTCGGCATTGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCGCGCGTGGAAGCGGCATACCGTATTCTGAGCGCTCTGCAGTAA", "partial": "0", "query_start": 1861, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.83}, "gnl|BL_ORD_ID|1089|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACT-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1155", "ARO_accession": "3001826", "ARO_name": "ACT-9", "ARO_category": {"36211": {"category_aro_accession": "3000072", "category_aro_cvterm_id": "36211", "category_aro_name": "ACT beta-lactamase", "category_aro_description": "ACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.78868e-99, "max_identities": 141, "bit_score": 294.664, "cvterm_id": "36950", "query": "SATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "+ +L  ALL  ++    AA      ++ VV+ T+ PLM  Q IPGMAVAV  +G+P+YF +G AD+ A +PVT  TLFELGS+SKTFTGVLG  ++A+ E++L DP  KY PEL   QW+GI +LDLATYTAGGLPLQVPD V     LL FYQ WQP  KPG  RLYAN+SIGLFGAL    +GM +EQ +T R+  PL L HT+I VP+  ++ YA+GY++ K + VSPG LDAE+YGVK+  +DM  W + NM P ", "sequence_from_db": "TKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVTANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNTSLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMNFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPD", "sequence_from_broadstreet": "MKTKSLCCALLLSTSCSVLAAPMSEKQLSDVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVTANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNTSLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMNFEQAMTKRVFKPLKLDHTWINVPKEEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNIQDMASWLKANMNPDALSDSTLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVEAKTVVEGSDNKVALAPLLVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKSYPNPARVEAAYRILSAL", "dna_sequence_from_broadstreet": "ATGAAGACAAAATCCCTTTGCTGTGCCCTGCTGCTCAGCACCTCCTGCTCTGTTCTCGCCGCGCCGATGTCAGAGAAACAGCTGTCTGACGTGGTGGAACGTACCGTTACCCCCCTGATGAAAGCGCAAGCCATTCCGGGCATGGCGGTGGCGGTGATTTATCAGGGTCAGCCGCACTACTTTACCTTCGGAAAGGCCGATGTTACGGCGAACAAACCTGTCACCCCGCAAACCCTGTTTGAGCTGGGCTCTATAAGTAAAACCTTCACCGGCGTATTAGGTGGCGATGCGATTGCGCGCGGAGAAATATCGCTGGGCGACCCCGTGACAAAGTACTGGCCCGAGCTAACAGGCAAGCAGTGGCAGGGTATTCGCATGTTGGATCTGGCGACCTACACCGCGGGTGGCCTGCCGCTACAGGTGCCGGATGAGGTCACGGATAACACCTCCCTGCTGCGTTTCTATCAACACTGGCAACCGCAGTGGAAACCAGGCACAACGCGTCTTTATGCGAACGCCAGCATCGGGCTTTTTGGCGCCCTCGCGGTTAAACCCTCCGGTATGAACTTTGAACAGGCCATGACGAAGCGGGTCTTCAAGCCACTCAAACTGGACCATACATGGATTAACGTTCCGAAAGAAGAAGAGGCGCATTACGCCTGGGGATACCGTGATGGTAAAGCAATCCACGTTTCACCGGGAATGCTGGATGCCGAAGCGTATGGTGTCAAAACCAACATCCAGGATATGGCGAGCTGGCTGAAGGCCAACATGAACCCTGACGCCCTTTCGGATTCAACGTTGAAACAGGGTATTGCCCTGGCACAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAGGGTCTGGGCTGGGAGATGCTCAACTGGCCGGTAGAAGCCAAAACCGTCGTGGAGGGCAGCGATAACAAGGTGGCTCTTGCACCGTTACTGGTGGCAGAAGTGAACCCTCCAGCTCCGCCAGTAAAAGCATCATGGGTACATAAAACAGGCTCGACGGGTGGATTCGGCAGCTATGTCGCATTTATTCCTGAAAAGGAACTCGGCATTGTTATGCTGGCGAACAAGAGCTACCCGAACCCGGCGCGCGTGGAAGCGGCATACCGTATTTTGAGCGCTCTGTAG", "partial": "0", "query_start": 1861, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 54.44}, "gnl|BL_ORD_ID|2047|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1", "ARO_accession": "3002501", "ARO_name": "PDC-4", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.70112e-86, "max_identities": 130, "bit_score": 261.151, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ EM L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDEMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDEMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACGAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.43}, "gnl|BL_ORD_ID|2542|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-82", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2861", "ARO_accession": "3004345", "ARO_name": "PDC-82", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.6625e-85, "max_identities": 125, "bit_score": 259.61, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ+PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+LL  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQLPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLLEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQLPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLLEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGCTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCCTGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.23}, "gnl|BL_ORD_ID|327|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "352", "ARO_accession": "3002502", "ARO_name": "PDC-5", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.6974e-85, "max_identities": 129, "bit_score": 259.225, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCAGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.05}, "gnl|BL_ORD_ID|672|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "715", "ARO_accession": "3002500", "ARO_name": "PDC-3", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.12141e-85, "max_identities": 129, "bit_score": 259.225, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.05}, "gnl|BL_ORD_ID|1060|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1130", "ARO_accession": "3002508", "ARO_name": "PDC-9", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.46434e-85, "max_identities": 128, "bit_score": 259.225, "cvterm_id": "36752", "query": "SLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P  +    AD + A+VD+ ++P+M   DIPG+ VA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K RA + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAVEAPADRLKALVDAAVQPVMKANDIPGLTVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDRAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAVEAPADRLKALVDAAVQPVMKANDIPGLTVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDRAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGTCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGACCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCGGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|2536|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-76", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2855", "ARO_accession": "3004339", "ARO_name": "PDC-76", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.63868e-85, "max_identities": 124, "bit_score": 258.07, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPIAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGTCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCCCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCATTGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.82}, "gnl|BL_ORD_ID|636|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "678", "ARO_accession": "3002509", "ARO_name": "PDC-10", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.47453e-85, "max_identities": 129, "bit_score": 258.84, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFAATPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFAATPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCGCCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.05}, "gnl|BL_ORD_ID|2533|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-73", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2852", "ARO_accession": "3004336", "ARO_name": "PDC-73", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.64094e-85, "max_identities": 124, "bit_score": 258.07, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTATGCGCCGGGCAGCCAGCGCCTCTATTCCAACCTGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGACTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.82}, "gnl|BL_ORD_ID|2541|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-81", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2860", "ARO_accession": "3004344", "ARO_name": "PDC-81", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.24191e-85, "max_identities": 124, "bit_score": 257.684, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNLSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCTGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.82}, "gnl|BL_ORD_ID|2549|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-89", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2868", "ARO_accession": "3004352", "ARO_name": "PDC-89", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.23931e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGTCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCAATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGGCGCTGCAGCCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2552|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-92", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2871", "ARO_accession": "3004355", "ARO_name": "PDC-92", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.27692e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMAPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2550|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-90", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2869", "ARO_accession": "3004353", "ARO_name": "PDC-90", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30819e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCCGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACTCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2547|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-87", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2866", "ARO_accession": "3004350", "ARO_name": "PDC-87", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.46207e-84, "max_identities": 123, "bit_score": 257.299, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPIAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCTTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCGCTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCATTGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2548|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-88", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2867", "ARO_accession": "3004351", "ARO_name": "PDC-88", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.48568e-84, "max_identities": 123, "bit_score": 256.914, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCTTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCGCTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGATGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2551|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-91", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2870", "ARO_accession": "3004354", "ARO_name": "PDC-91", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.59341e-84, "max_identities": 123, "bit_score": 256.914, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSLQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCTTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCGCTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|2553|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-93", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2872", "ARO_accession": "3004356", "ARO_name": "PDC-93", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.5942e-84, "max_identities": 123, "bit_score": 256.914, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMAPQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCCGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.25}, "gnl|BL_ORD_ID|1358|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1446", "ARO_accession": "3002505", "ARO_name": "PDC-6", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.68034e-84, "max_identities": 128, "bit_score": 257.684, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRQVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCAGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|572|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "612", "ARO_accession": "3002506", "ARO_name": "PDC-7", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.79283e-84, "max_identities": 128, "bit_score": 257.684, "cvterm_id": "36752", "query": "SLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P  +    AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGACGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|371|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "400", "ARO_accession": "3002497", "ARO_name": "PDC-1", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.85187e-84, "max_identities": 128, "bit_score": 257.684, "cvterm_id": "36804", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|2545|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-85", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2864", "ARO_accession": "3004348", "ARO_name": "PDC-85", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.65023e-84, "max_identities": 123, "bit_score": 256.529, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE +GVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGHGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGHGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCCATGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|95|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "108", "ARO_accession": "3002507", "ARO_name": "PDC-8", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.69645e-84, "max_identities": 128, "bit_score": 256.914, "cvterm_id": "36752", "query": "SLSATLISALLAFSAP---GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P   G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  R Y+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRRYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRRYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCGCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|1038|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "1107", "ARO_accession": "3002498", "ARO_name": "PDC-2", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.39363e-84, "max_identities": 128, "bit_score": 256.914, "cvterm_id": "36752", "query": "SLSATLISALLAFSAPGFSA---ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": " L     S LL  + P  +    AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "CLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTVTLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "MRDTRFPCLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTVTLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "ATGCGCGATACCAGATTCCCCTGCCTGTGCGGCATCGCCGCTTCCACACTGCTGTTCGCCACCACCCCGGCCATTGCCGACGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGTCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAACTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTATGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1855, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.67}, "gnl|BL_ORD_ID|2546|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-86", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2865", "ARO_accession": "3004349", "ARO_name": "PDC-86", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.39105e-84, "max_identities": 122, "bit_score": 254.988, "cvterm_id": "36752", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDA+ YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "ADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "DEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GATGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAATTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCAAAGGCTACGGGGTGAAGACCAGCGCCGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACTCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATTCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1915, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.83}, "gnl|BL_ORD_ID|2535|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-75", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2854", "ARO_accession": "3004338", "ARO_name": "PDC-75", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.39105e-84, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFIPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTATGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGACTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCCCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCATGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCATCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2544|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-84", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2863", "ARO_accession": "3004347", "ARO_name": "PDC-84", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.70065e-84, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+R  PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPIAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGCGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGCCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCATTGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2543|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-83", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2862", "ARO_accession": "3004346", "ARO_name": "PDC-83", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.70065e-84, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+R  PG LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPAMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRAGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCATTGGTCGACGCCGCCGTACAACCGGCGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGTCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGCCGGTCCCGGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCACACAGGATCGCTAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGCTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGCCTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTATGCCATCCTCAGCGGCCTGGAGCAGCAGGCCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2534|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-74", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2853", "ARO_accession": "3004337", "ARO_name": "PDC-74", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.03508e-83, "max_identities": 123, "bit_score": 254.988, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++A+ +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGGCCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTATGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGACTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.41}, "gnl|BL_ORD_ID|2539|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-79", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2858", "ARO_accession": "3004342", "ARO_name": "PDC-79", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.38595e-83, "max_identities": 122, "bit_score": 254.603, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDA+ YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAKGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTTCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCAAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2540|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-80", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2859", "ARO_accession": "3004343", "ARO_name": "PDC-80", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.91256e-83, "max_identities": 122, "bit_score": 253.447, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV PG LDA  YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAGGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAGGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTCCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCGGCCCGCTGGATGCCGGAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCACTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2537|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-77", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2856", "ARO_accession": "3004340", "ARO_name": "PDC-77", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.04152e-83, "max_identities": 122, "bit_score": 253.447, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L   ++ GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCGCTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTTCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2538|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "PDC-78", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2857", "ARO_accession": "3004341", "ARO_name": "PDC-78", "ARO_category": {"36237": {"category_aro_accession": "3000098", "category_aro_cvterm_id": "36237", "category_aro_name": "PDC beta-lactamase", "category_aro_description": "PDC beta-lactamases are class C beta-lactamases that are found in Pseudomonas aeruginosa.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.2201e-83, "max_identities": 122, "bit_score": 253.447, "cvterm_id": "36752", "query": "GFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAV-KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "G + AD + A+VD+ ++P+M   DIPG+AVA+S+KG+P+YF+YG A  +  + VT  TLFE+GSVSKTFT  L   ++ + +M L+D A+++ P L    + GI+LLDLATYTAGGLPLQ PD+V K +A + ++Y+QWQP+  PG  RLY+N SIGLFG L A + G P+E+L+  ++   LGL  T + VPE+A +QYA GY K+ +P+RV P  LDAE YGVK+++ D+LR+ + N+ P R", "sequence_from_db": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSHFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPER", "sequence_from_broadstreet": "GEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSHFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPRPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR", "dna_sequence_from_broadstreet": "GGCGAGGCCCCGGCGGATCGCCTGAAGGCACTGGTCGACGCCGCCGTACAACCGGTGATGAAGGCCAATGACATTCCGGGCCTGGCCGTAGCCATCAGCCTGAAAGGAGAACCGCATTACTTCAGCTATGGGCTGGCCTCGAAAGAGGACGGCCGCCGGGTGACGCCGGAGACCCTGTTCGAGATCGGCTCGGTGAGCAAGACCTTCACCGCCACCCTCGCCGGCTATGCCCTGACCCAGGACAAGATGCGCCTCGACGACCGCGCCAGCCAGCACTGGCCGGCACTGCAGGGCAGCCACTTCGACGGCATCAGCCTGCTCGACCTCGCGACCTATACCGCCGGCGGCTTGCCGCTGCAGTTTCCCGACTCGGTGCAGAAGGACCAGGCACAGATCCGCGACTACTACCGCCAGTGGCAGCCGACCTACGCGCCGGGCAGCCAGCGCCTCTATTCCAACCCGAGCATCGGCCTGTTCGGCTATCTCGCCGCGCGCAGCCTGGGCCAGCCGTTCGAACGGCTCATGGAGCAGCAAGTGTTCCCGGCACTGGGCCTCGAACAGACCCACCTCGACGTGCCCGAGGCGGCGCTGGCGCAGTACGCCCAGGGCTACGGCAAGGACGACCGCCCGCTACGGGTCGGTCCCCGCCCGCTGGATGCCGAAGGCTACGGGGTGAAGACCAGCGCGGCCGACCTGCTGCGCTTCGTCGATGCCAACCTGCATCCGGAGCGCCTGGACAGGCCCTGGGCGCAGGCGCTCGATGCCACCCATCGCGGTTACTACAAGGTCGGCGACATGACCCAGGGCCTGGGCTGGGAAGCCTACGACTGGCCGATCTCCCTGAAGCGCCTGCAGGCCGGCAACTCGACGCCGATGGCGCTGCAACCGCACAGGATCGCCAGGCTGCCCGCGCCACAGGCGCTGGAGGGCCAGCGCCTGCTGAACAAGACCGGTTCCACCAACGGCTTCGGCGCCTACGTGGCGTTCGTCCCGGGCCGCGACCTGGGACTGGTGATCCTGGCCAACCGCAACTATCCCAATGCCGAGCGGGTGAAGATCGCCTACGCCATCCTCAGCGGCCTGGAGCAGCAGGGCAAGGTGCCGCTGAAGCGCTGA", "partial": "0", "query_start": 1903, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|494|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "528", "ARO_accession": "3002521", "ARO_name": "OCH-8", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.57476e-80, "max_identities": 116, "bit_score": 247.284, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALATSKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTACGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAACCCGATTATCCGGCAGGGACGCAGCGTCGTTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.15}, "gnl|BL_ORD_ID|186|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "201", "ARO_accession": "3002516", "ARO_name": "OCH-3", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.97598e-80, "max_identities": 116, "bit_score": 246.899, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A     L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFTLSDPATKWAPELADSSFDKITMLDLGTYTPGGLPLQFPDAVSDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALAASKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFTLSDPATKWAPELADSSFDKITMLDLGTYTPGGLPLQFPDAVSDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYRVDANNQGLGWEFYNYPTALKTLLEGNSSDMALKSHKIEKFDTPSQPSADVWLNKTGSTNGFGAYAAFIPAKKIGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTGCGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAGGAAAGCGGGCAAAAAGTCACCGAAGACACGATTTTCGAGATCGGCTCGGTCAGCAAGACCTTCACTGCAATGCTCGGCGGCTACGGGCTGGCGACAGGCGCGTTCACTCTGTCCGATCCCGCGACCAAATGGGCCCCCGAACTGGCAGACAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCTCCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGCACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCGTGTCGATGCGAACAATCAGGGGCTTGGCTGGGAGTTCTACAACTATCCGACCGCGCTCAAGACGCTTCTTGAGGGCAACTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTAGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTCTGCTTGCCAACCGGAACTATCCGATTGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.15}, "gnl|BL_ORD_ID|713|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "759", "ARO_accession": "3002515", "ARO_name": "OCH-2", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.27938e-80, "max_identities": 116, "bit_score": 246.514, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L +++ W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKNWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRTSTTLLIGFLTTAAVIPNNGALAASKVNDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKNWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLELDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERIKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAACATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTGTTATCCCGAATAACGGCGCGCTGGCTGCGAGCAAGGTGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAGGAAAGCGGGCAAAAAGTCACCGAAGACACGATTTTCGAGATCGGCTCGGTCAGCAAGACCTTCACTGCAATGCTCGGCGGCTACGGGCTTGCGACCGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCCGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAACTGGAAACCCGATTACCCGGCAGGGACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCTTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCATAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.15}, "gnl|BL_ORD_ID|1148|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1220", "ARO_accession": "3002518", "ARO_name": "OCH-5", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.53964e-80, "max_identities": 115, "bit_score": 245.358, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+LDL TYT GGLPLQ PDAV   + +L ++++W+P    G    Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWRPDYPAGTQHRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGTLDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALAASKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWRPDYPAGTQHRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGTLDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVDANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVVLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAACGGCGCGCTGGCTGCGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAGGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGCTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGCTACGGGCTGGCGACGGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCTTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAGGCCGGACTATCCGGCAGGCACGCAGCATCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGACGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATTGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACACACACGGGTTACTACCATGTCGATGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTGTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.73}, "gnl|BL_ORD_ID|1601|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1698", "ARO_accession": "3002519", "ARO_name": "OCH-6", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.38573e-79, "max_identities": 115, "bit_score": 244.588, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VPES    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALAASKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPESQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTGCGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGCACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGAAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAATCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.73}, "gnl|BL_ORD_ID|727|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "773", "ARO_accession": "3002517", "ARO_name": "OCH-4", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.52394e-78, "max_identities": 114, "bit_score": 242.276, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VP S    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNNGALATSKANDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAATGGCGCGCTGGCTACGAGCAAGGCGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCCGTCGCTATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGCACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGCAAGCCAGATGAAGAACTACGCCTACGGATATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGATCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.31}, "gnl|BL_ORD_ID|694|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LRA-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "739", "ARO_accession": "3002492", "ARO_name": "LRA-18", "ARO_category": {"41395": {"category_aro_accession": "3004231", "category_aro_cvterm_id": "41395", "category_aro_name": "class C LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.705e-78, "max_identities": 121, "bit_score": 242.276, "cvterm_id": "39683", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGF", "match": "VD+ + P+MAQ D+PGMAVAV+V G+P++FNYG A   +KQPVTE T+FELGS SKTFT  L A + A+ ++AL+D   KY P+L      G TLL L TYTAGG PLQ+PD +K+R  L +++Q W+P   PG  R Y+N SIGLFG +   A G  +       +   LGL HT+I VP+SA + YA+GY   + VRV P   D+E+YGVKS + DM+R+ ++ ++PSR                 AP+R    AT  G+", "sequence_from_db": "VDAAVGPVMAQFDVPGMAVAVTVDGQPHFFNYGVAARDSKQPVTEATIFELGSNSKTFTATLAAYAQAQGKLALDDHPGKYVPQLQGSALDGATLLHLGTYTAGGFPLQIPDNLKTREQLFSYFQHWKPDAAPGKQRNYSNPSIGLFGHIAGLALGGGFADAAERDLFPQLGLQHTYIRVPQSAMAHYAWGYSKDQAVRVQPDLFDSEAYGVKSTAADMIRYVQLQIDPSRL---------------AAPMRRAVQATHTGY", "sequence_from_broadstreet": "MLKRIRLPQLALALAALFPLAAYAAPDAAALRQAVDAAVGPVMAQFDVPGMAVAVTVDGQPHFFNYGVAARDSKQPVTEATIFELGSNSKTFTATLAAYAQAQGKLALDDHPGKYVPQLQGSALDGATLLHLGTYTAGGFPLQIPDNLKTREQLFSYFQHWKPDAAPGKQRNYSNPSIGLFGHIAGLALGGGFADAAERDLFPQLGLQHTYIRVPQSAMAHYAWGYSKDQAVRVQPDLFDSEAYGVKSTAADMIRYVQLQIDPSRLAAPMRRAVQATHTGYFKAGPMTQGLGWESYPYPVSLEQLLQGNSTDMAWKPQPVQAIQPVQTAAPALYNKTGSTRGFGSYVAFVPSQKIGIVLLANRAYPNDARIKLAYAILNQLAPAAN", "dna_sequence_from_broadstreet": "ATGTTGAAACGTATCCGCTTGCCCCAACTGGCGCTGGCCCTTGCGGCGCTGTTCCCCTTGGCCGCCTACGCGGCGCCGGACGCCGCCGCGCTGCGCCAGGCCGTCGACGCGGCAGTCGGCCCCGTCATGGCGCAGTTCGATGTGCCGGGCATGGCGGTCGCCGTCACGGTCGATGGCCAGCCGCACTTTTTCAATTACGGCGTCGCCGCGCGCGACAGCAAGCAACCCGTGACGGAAGCGACCATCTTTGAGTTGGGTTCGAACAGCAAGACTTTTACGGCCACCCTGGCGGCCTATGCCCAGGCGCAAGGCAAACTGGCGCTGGACGATCACCCCGGCAAGTATGTGCCGCAATTGCAGGGCAGTGCGCTCGATGGCGCCACCTTGCTGCACCTCGGCACCTACACGGCGGGCGGCTTTCCGTTGCAAATTCCGGACAACCTGAAAACCCGGGAGCAGTTGTTCAGTTACTTTCAGCACTGGAAACCGGACGCGGCGCCGGGCAAGCAGCGTAACTATTCCAATCCCAGCATCGGCCTATTCGGCCATATTGCCGGCCTGGCGCTCGGTGGCGGCTTTGCCGACGCGGCGGAGCGCGACTTGTTCCCGCAACTGGGTTTGCAACACACTTACATCCGCGTGCCGCAGTCAGCCATGGCCCATTACGCGTGGGGCTATTCGAAAGACCAGGCGGTCCGTGTCCAGCCTGATTTGTTCGATAGTGAAGCCTATGGCGTGAAATCCACGGCGGCCGACATGATCCGCTACGTGCAACTGCAAATCGACCCGTCGCGCCTGGCCGCACCGATGCGGCGCGCGGTGCAAGCGACCCATACCGGCTACTTCAAGGCCGGCCCGATGACGCAGGGACTGGGATGGGAATCGTACCCGTATCCCGTCAGCCTGGAGCAACTGTTGCAGGGCAATTCCACCGACATGGCGTGGAAGCCGCAGCCAGTCCAGGCAATACAACCAGTGCAGACCGCGGCCCCGGCCCTGTACAACAAGACCGGTTCCACGCGGGGCTTCGGCAGCTATGTCGCCTTTGTCCCGTCGCAAAAAATTGGTATCGTGCTGCTGGCCAACCGGGCTTATCCGAACGATGCGCGGATCAAGCTGGCGTATGCGATCTTGAATCAGCTGGCCCCGGCGGCAAATTGA", "partial": "0", "query_start": 1936, "query_end": 2721, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.18}, "gnl|BL_ORD_ID|170|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "184", "ARO_accession": "3002514", "ARO_name": "OCH-1", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.85026e-78, "max_identities": 114, "bit_score": 242.276, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VP S    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNSGALAASKVNDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLEGNSSDMALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAGCGGCGCGCTGGCTGCGAGCAAGGTGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGGACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGCAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACGCTTCTTGAGGGCAACTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGCTGATCAATAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.31}, "gnl|BL_ORD_ID|397|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OCH-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "427", "ARO_accession": "3002520", "ARO_name": "OCH-7", "ARO_category": {"36233": {"category_aro_accession": "3000094", "category_aro_cvterm_id": "36233", "category_aro_name": "OCH beta-lactamase", "category_aro_description": "OCH beta-lactamases are Ambler class C chromosomal-encoded beta-lactamases in Ochrobactrum anthropi", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "40360": {"category_aro_accession": "3003706", "category_aro_cvterm_id": "40360", "category_aro_name": "penem", "category_aro_description": "Penems are a class of unsaturated beta-lactam antibiotics with a broad spectrum of antibacterial activity and have a structure which renders them highly resistant to beta-lactamases. All penems are all synthetically made and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. They are structurally similar to carbapenems, however, where carbapenems have a carbon, penems have a sulfur.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.15164e-78, "max_identities": 114, "bit_score": 241.891, "cvterm_id": "37077", "query": "NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++  +VD T++PLMA+Q IPGMAVA+++ GK ++F YG A  ++ Q VTE+T+FE+GSVSKTFT +LG   +A    +L+DPA K+ PELA   +  IT+ DL TYT GGLPLQ PDAV   + +L ++++W+P    G  R Y+N SIGLFG L A +   P++ L+  ++L   GL +TFI VP S    YAYGY K  KP+RVS G LDA++YG+K+ + D+ R+ E+N++ S", "sequence_from_db": "DLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSS", "sequence_from_broadstreet": "MRKSTTLLIGFLTTAAIIPNSGALAASKVNDGDLRRIVDETVRPLMAEQKIPGMAVAITIDGKSHFFGYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGLATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDAVTDDSSMLAYFKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAFGLKNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAYGIKTTALDLARFVELNIDSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDMALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRNYPIDERVKAAYRILQALDNKQ", "dna_sequence_from_broadstreet": "ATGAGAAAATCTACGACACTTTTGATCGGTTTCCTCACCACTGCCGCTATTATCCCGAATAGCGGCGCGCTGGCTGCGAGCAAGGTGAATGATGGCGACTTGCGCCGTATTGTCGATGAAACGGTGCGCCCGCTCATGGCCGAGCAGAAAATCCCCGGCATGGCGGTTGCCATAACCATCGACGGCAAGAGCCACTTCTTCGGTTATGGTGTGGCATCGAAAGAAAGCGGGCAAAAAGTCACTGAAGACACGATTTTCGAGATCGGTTCGGTCAGCAAGACCTTCACTGCAATGCTTGGCGGTTACGGGCTGGCGACAGGCGCGTTCTCCCTGTCCGATCCCGCGACCAAATGGGCTCCTGAACTGGCAGGCAGCAGCTTCGACAAGATCACCATGCGTGATCTTGGGACCTACACGCCGGGCGGATTGCCCCTCCAGTTTCCCGATGCTGTCACCGATGACAGTTCGATGCTGGCATATTTCAAGAAATGGAAGCCGGACTATCCGGCAGGGACGCAGCGTCGCTATTCGAATCCCAGCATCGGCCTGTTCGGCTATCTGGCGGCACGAAGCATGGACAAGCCGTTCGACGTTTTGATGGAGCAAAAGCTTCTGCCTGCATTCGGCCTGAAGAACACCTTCATCAATGTGCCGGCAAGCCAGATGAAGAACTACGCCTACGGCTATTCCAAAGCCAACAAGCCGATCCGGGTATCGGGCGGGGCGCTGGATGCACAAGCCTATGGCATCAAGACCACCGCGCTTGATCTTGCCCGCTTCGTCGAACTGAACATCGACAGCTCATCTCTGGAGCCTGATTTCCAGAAAGCCGTCGCCGCAACGCATACCGGTTACTACCATGTCGGAGCGAACAATCAGGGACTTGGCTGGGAGTTCTACAACTATCCGACTGCGCTCAAGACACTTCTTGCCGGCAATTCGTCGGACATGGCGCTGAAGTCGCACAAAATCGAGAAATTCGATACACCTCGCCAACCGTCAGCTGATGTGTGGCTCAACAAGACAGGCTCAACCAACGGCTTTGGCGCTTATGCGGCCTTTATTCCTGCGAAGAAGACCGGAATTGTTCTGCTTGCCAACCGGAATTATCCGATCGATGAGCGCGTAAAGGCTGCCTATCGGATATTGCAGGCGCTCGACAACAAGCAATAG", "partial": "0", "query_start": 1921, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.31}, "gnl|BL_ORD_ID|478|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "509", "ARO_accession": "3002155", "ARO_name": "FOX-1", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.06457e-78, "max_identities": 124, "bit_score": 241.121, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSG", "match": "+ A VD  I+P++ +  IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KPVRV+PG L AE+YG+K+ S D+L++ E NM     G+A AL T + ++ +G", "sequence_from_db": "LTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFTEANM--GYQGDA-ALKTRIALTHTG", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKTRIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCCGCGGGGAGGCTCCGCTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATGGCGGTCGCCGTGCTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGTCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTTGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGCACTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATTCAGGTGCCGGAGTCGGCCATAGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGTCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTACCGAGGCCAACATGGGGTATCAGGGAGATGCCGCGCTAAAAACGCGGATCGCGCTGACCCATACCGGTTTCTACTCGGTGGGAGACATGACTCAGGGGCTGGGTTGGGAGAGCTACGCCTATCCGTTGACCGAGCAGGCGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2679, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.01}, "gnl|BL_ORD_ID|1613|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "AQU-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "1711", "ARO_accession": "3002993", "ARO_name": "AQU-1", "ARO_category": {"39426": {"category_aro_accession": "3002992", "category_aro_cvterm_id": "39426", "category_aro_name": "AQU beta-lactamase", "category_aro_description": "AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.29531e-77, "max_identities": 115, "bit_score": 239.58, "cvterm_id": "39651", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "AD +  VVD  I+PL+ +  IPGMAVAV  +G+P+YFNYG A++   + V+E TLFE+GSVSKT+T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V+S   +  +Y+QW P+ +PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT+I VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ADPLVGVVDEVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTYTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MKQTSPLSSLALSALLLSPLTQAAPADPLVGVVDEVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTYTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANINGVDDKGLQQAIALTHQGRYSVGEMTQGLGWESYPYPVSEQTLLAGNSVQVIMKANPTTAAPKEMGSQRLFNKTGSTNGFGAYVAFVPAKGVGIVMLANRNYPIQERVKAAHSILSKLAP", "dna_sequence_from_broadstreet": "ATGAAGCAAACCTCACCCTTGTCGTCGCTGGCGCTGAGCGCCCTGCTGCTGTCGCCCCTCACCCAGGCCGCTCCCGCCGATCCGCTGGTCGGGGTAGTGGATGAGGTCATTCGTCCGCTGGTGAAAGAGCACAGGATCCCGGGCATGGCGGTAGCCGTGTTCAAAGAGGGGCAACCCCACTACTTCAACTACGGGGTTGCCGAGCTGGCGACGGGGAAGAAGGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAAACCTATACCGCCACCCTGGGGGCCTACGCCGTGGTCAAGGGGAGCATTGGGCTGGATGACAAGGTGAGCCGGCACGCTCCCTGGCTCAAGGGCTCCGCCTTTGATGGCATCACCATGGCCGAGCTTGCCACTTACAGTGCCGGGGGTCTGCCGCTGCAATTCCCCGACGAGGTGGAATCGCTCGAGCAGATGCAGGCTTACTATCGCCAGTGGACGCCGGCCTATCAACCAGGCAGCCATCGCCAGTACTCCAACCCCAGTATCGGCCTGTTCGGCTATCTGGCGGCGAGCAGTCTGCAGCAGCCGTTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCCTGCATCACACCTATATCAATGTGCCGAAGCAGGCGATGGCGAACTACGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCACGCCAGGGGTGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCAACGGGGTGGATGACAAGGGATTGCAGCAGGCCATCGCTTTGACCCACCAGGGGCGCTACTCGGTAGGCGAGATGACCCAGGGGCTGGGCTGGGAGAGTTACCCCTATCCGGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCGGTCCAGGTGATCATGAAGGCCAATCCGACGACGGCCGCGCCGAAGGAGATGGGGAGCCAGCGGCTCTTCAACAAGACCGGCTCGACCAACGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAAGGGAGTGGGCATCGTCATGCTGGCCAACCGCAACTACCCCATCCAGGAGAGGGTAAAGGCGGCCCACTCCATCCTGAGCAAGCTGGCTCCCTGA", "partial": "0", "query_start": 1915, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.94}, "gnl|BL_ORD_ID|2186|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "AQU-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3346", "ARO_accession": "3004647", "ARO_name": "AQU-2", "ARO_category": {"39426": {"category_aro_accession": "3002992", "category_aro_cvterm_id": "39426", "category_aro_name": "AQU beta-lactamase", "category_aro_description": "AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.03715e-77, "max_identities": 115, "bit_score": 239.195, "cvterm_id": "36810", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "AD +  VVD  I+PL+ +  IPGMAVAV  +G+P+YFNYG A++   + V+E TLFE+GSVSKT T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V+S   +  +Y+QW P+ +PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT+I VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ADPLVGVVDDVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVQANI", "sequence_from_broadstreet": "MKQTSPLSLLALSALLLSPLTQAAPADPLVGVVDDVIRPLVKEHRIPGMAVAVFKEGQPHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVQANINGVDDKGLQQAIALTHQGHYSVGGMTQGLGWESYPYPVSEQTLLAGNSAQVIMKANPTTAAPXEMGSQRLFNKTGSTNGFGAYVAFVPAKGVGIVMLANRNYPIQERVKAAHAILSKLAP", "dna_sequence_from_broadstreet": "ATGAAGCAAACCTCACCCTTGTCGTTGCTGGCGCTGAGCGCCCTGCTGCTGTCGCCCCTCACCCAGGCCGCTCCCGCCGATCCGCTGGTCGGGGTAGTGGATGACGTCATTCGTCCGCTGGTGAAAGAGCACAGGATCCCGGGCATGGCGGTAGCCGTGTTCAAAGAGGGGCAACCCCACTACTTCAACTACGGGGTTGCCGAGCTGGCGACGGGGAAGAAGGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTGGGGGCCTACGCCGTGGTCAAGGGGAGCATTGGGCTGGATGACAAGGTGAGCCGGCACGCTCCCTGGCTCAAGGGCTCCGCCTTTGATGGCATTACCATGGCCGAGCTTGCCACTTACAGTGCCGGGGGTCTGCCGCTGCAATTCCCCGACGAGGTGGAATCGCTCGAGCAGATGCAGGCTTACTATCGCCAGTGGACGCCGGCCTATCAACCAGGCAGCCATCGCCAGTACTCCAACCCCAGTATCGGCCTGTTCGGCTATCTGGCGGCGAGCAGTCTGCAGCAGCCGTTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCCTGCATCACACCTATATCAATGTGCCGAAGCAGGCCATGGCGAACTACGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAATCCCGGCATGCTGGCCGACGAGGCCTACGGCATCAAGACTAGCTCGGCGGATCTGCTCGCCTTCGTGCAGGCCAACATCAACGGGGTGGATGACAAGGGGTTGCAGCAGGCCATCGCTTTGACCCACCAGGGGCACTACTCGGTAGGCGGGATGACTCAGGGGCTGGGCTGGGAGAGTTACCCCTATCCGGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCGGCCCAGGTGATCATGAARGCCAATCCGACGACGGCCGCGCCGAAKGAGATGGGGAGCCAGCGGCTCTTCAACAAGACTGGCTCGACCAACGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAAGGGAGTGGGCATCGTCATGCTGGCCAACCGCAACTACCCCATCCAGGAGAGGGTAAAGGCGGCCCACGCCATCCTGAGCAAGCTGGCTCCCTGA", "partial": "0", "query_start": 1915, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.94}, "gnl|BL_ORD_ID|71|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "81", "ARO_accession": "3002157", "ARO_name": "FOX-3", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.6472e-77, "max_identities": 117, "bit_score": 238.81, "cvterm_id": "36788", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPG+AVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KP+RV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCAGCGGGGAGGCCCCGCTGACCGCCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATAGCGGTCGCCGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGTGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATAAGGTGGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCAGGGACTCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCATCCGGGTCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCCTGGTAAAAAGCGCAATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGGGAAATGACCCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.43}, "gnl|BL_ORD_ID|1053|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1123", "ARO_accession": "3002161", "ARO_name": "FOX-8", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.94848e-77, "max_identities": 117, "bit_score": 238.81, "cvterm_id": "35914", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPG+AVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KP+RV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSLQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCAGCGGGGAGGCCCCGCTGACCGCCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATAGCGGTCGCCGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGTGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATAAGGTGGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCAGGGACTCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCATCCGGGTCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCCTGGTAAAAAGCGCAATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGGGAAATGACCCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCCTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.43}, "gnl|BL_ORD_ID|1174|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1249", "ARO_accession": "3002159", "ARO_name": "FOX-5", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.81892e-77, "max_identities": 119, "bit_score": 238.424, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA   YAYGY K  KPVRV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGGCGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGTTAGCCCCTTGTACTTATGCCAGCGGGGAGGCTCCGTTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCCGTACTGAAAGATGGCAAAGCCCACTATTTCAACTATGGGGTTGCCAACCGGGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACTGCGACCCTCGGTGCCTATGCCGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATCGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTACCGGAGTCGGCTATGGTGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGTCACTCCGGGCGTGCTGGCAGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGGTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACCCAGGGACTGGGCTGGGAGAGTTACGCCTATCCGGTGACCGAGCAGACATTGCTGGCGGGTAACGCACCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAGGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 51.29}, "gnl|BL_ORD_ID|543|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "582", "ARO_accession": "3002160", "ARO_name": "FOX-7", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.16281e-77, "max_identities": 117, "bit_score": 238.424, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KPVR +PG L AE+YG+K+ S D+L++ E NM", "sequence_from_db": "LTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRATPGVLAAEAYGIKTGSADLLKFTEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRATPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCCGCGGGGAGGCTCCGCTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATGGCGGTCGCCGTGCTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGTCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTTGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGCACTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATTCAGGTGCCGGAGTCGGCCATAGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGCCACTCCGGGCGTGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTACCGAGGCCAACATGGGGTATCAGGGAGATGCCGCGCTAAAAAGCGCGATCGCGCTGACCCATACCGGTTTCTACTCGGTGGGAGACATGACTCAGGGGCTGGGTTGGGAGAGCTACGCCTATCCGTTGACCGAGCAGGCGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.43}, "gnl|BL_ORD_ID|718|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "764", "ARO_accession": "3002156", "ARO_name": "FOX-2", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.45007e-77, "max_identities": 116, "bit_score": 238.039, "cvterm_id": "35914", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++ +  IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  + + P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+E+L++  +L  LGL HT+I VPESA + YAYGY K  KP+RV+PG L AE+YG+K+ S D+L++ E NM", "sequence_from_db": "LTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSHHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEKLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFVEANM", "sequence_from_broadstreet": "MQQRRALALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSHHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEKLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGCTCGCGCTACTGACGCTGGGTAGCCTGCTGCTAGCCCCTTGTACTTATGCCAGCGGGGAGGCTCCGCTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGAGTATCGGATCCCGGGGATGGCGGTCGCCGTGCTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGCCAGCGCGTCAGCGAGCAGACGCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTCGGTGCCTATGCTGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCACCACGCCCCTTGGCTCAAAGGTTCCGCTTTCGATGGTGTGACTATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCTGATGAGGTGGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGAAACTGATGAGCCAGACCCTGCTGCCCAAGCTTGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCATCCGGGTCACTCCGGGCGTACTGGCGGCCGAGGCTTACGGGATCAAAACCGGCTCGGCGGATCTGCTGAAGTTTGTCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGCTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACCCAGGGACTGGGCTGGGAGAGCTACGCCTATCCGGTGACCGAGCAGGCGTTGCTGGCGGGCAACTCCCCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACCGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|934|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "990", "ARO_accession": "3002163", "ARO_name": "FOX-9", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.76099e-77, "max_identities": 116, "bit_score": 238.039, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+   VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ P+ V S   +  +Y+ W P    G  R YAN+SIGLFG L AN+ G  +EQL++  +L  LGL HT+I VPESA + YAYGY K +KP+RV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTVTVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPEEVDSNDKMRTYYRSWSPVYPAGTHRQYANTSIGLFGYLAANSLGQSFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEEKPIRVTPGMLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTVTVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPEEVDSNDKMRTYYRSWSPVYPAGTHRQYANTSIGLFGYLAANSLGQSFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEEKPIRVTPGMLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYDYPVTEQVLLADNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGTTAGCCCCTTGTACCTATGCCAGCGGGGAGGCCCCGCTGACCGTCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCCGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGTGGTCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAAACCCTGACCGCGACCCTTGGCGCTTATGCAGCGGTCAAGGGAGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTGAAAGGTTCCGCCTTTGATGGGGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGAAGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGAGTTGGTCACCGGTTTATCCGGCGGGGACCCACCGTCAGTACGCCAATACCAGTATCGGTCTGTTCGGCTATCTGGCTGCCAACTCCCTGGGCCAGTCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGAGAAGCCCATCCGGGTCACTCCGGGCATGCTGGCGGCCGAGGCTTACGGGATCAAGACCGGTTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGGTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACTCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGACAACTCACCAGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGTTTTGCTGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACCGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATAGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|1626|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1726", "ARO_accession": "3002158", "ARO_name": "FOX-4", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.46882e-76, "max_identities": 116, "bit_score": 236.884, "cvterm_id": "35914", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L    + G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SIGLFG L AN+ G P+EQL++  +L  LGL HT+I VPESA + YAYGY K  KP+R +PG L AE+YG+K+ S D+L++ E NM", "sequence_from_db": "LTATVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRATPGVLAAEAYGIKTGSADLLKFVEANM", "sequence_from_broadstreet": "MQQRRALALLMLGSLLLAPCTYASGEAPLTATVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRATPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAALKSAIALTHTGFHSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGACGTGCGCTCGCGCTACTGATGCTGGGTAGCCTGCTGTTAGCCCCTTGCACTTATGCCAGCGGGGAGGCCCCGCTGACCGCCACTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCTGTACTGAAAGATGGCAAGGCCCACTATTTCAACTATGGGGTTGCCAACCGCGAGAGCGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTTGGCGCCTATGCCGCAGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTTGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTAGATTCGAATGACAAGATGCAAACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACTCATCGCCAGTATTCCAACCCCAGCATAGGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAACTGGGTTTGCACCACACCTATATCCAGGTGCCGGAGTCGGCCATGGCGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCTATCCGGGCCACTCCGGGCGTGCTGGCTGCCGAGGCTTACGGGATCAAGACCGGTTCGGCGGATCTGCTGAAGTTTGTCGAGGCCAACATGGGGTATCAGGGAGATGCCGCGCTAAAAAGCGCGATCGCGCTGACCCACACCGGCTTCCATTCGGTGGGGGAAATGACCCAGGGGCTGGGCTGGGAGAGTTACGACTATCCCGTCACCGAGCAGGTGCTGCTGGCGGGCAACTCACCAGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAAGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGTGGCTTTGGCGCCTATGTGGCGTTCGTGCCTGCCAGAGGGATAGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|1713|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1813", "ARO_accession": "3002184", "ARO_name": "MOX-4", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.08778e-76, "max_identities": 124, "bit_score": 235.728, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA  A   SA D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAH-AGDTSAVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGDTSAVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSAEVILEANPTAAPRESGNLMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTTTGGCCACCCTGATGTGGGCCGGTCTGGCTCATGCCGGTGACACTTCAGCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCGGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCATGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGAGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAATTCGGCCGAGGTGATTCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAACCTGATGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 49.21}, "gnl|BL_ORD_ID|392|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "FOX-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "422", "ARO_accession": "3002162", "ARO_name": "FOX-10", "ARO_category": {"36206": {"category_aro_accession": "3000067", "category_aro_cvterm_id": "36206", "category_aro_name": "FOX beta-lactamase", "category_aro_description": "FOX beta-lactamases are plasmid-encoded AmpC-type beta-lactamase which conferred resistance to broad-spectrum cephalosporins and cephamycins", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.22205e-76, "max_identities": 118, "bit_score": 235.728, "cvterm_id": "35915", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+ A VD  I+P++    IPGMAVAV   GK +YFNYG A+ ++ Q V+E TLFE+GSVSKT T  LGA +  K    L+D  +++ P L      G+T+ +LATY+AGGLPLQ PD V S   +  +Y+ W P    G  R Y+N SI LFG L AN+ G P+EQL++  +L  LGL HT+I VPESA   YAYGY K  KPVRV+PG L AE+YG+K+ S D+L++AE NM", "sequence_from_db": "LTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSISLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANM", "sequence_from_broadstreet": "MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSISLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE", "dna_sequence_from_broadstreet": "ATGCAACAACGGCGTGCGTTCGCGCTACTGACGCTGGGTAGCCTGCTGTTAGCCCCTTGTACTTATGCCAGCGGGGAGGCTCCGTTGACCGCCGCTGTGGACGGCATTATCCAGCCGATGCTCAAGGCGTATCGGATCCCGGGGATGGCGGTCGCCGTACTGAAAGATGGCAAAGCCCACTATTTCAACTATGGGGTTGCCAACCGGGAGAGTGGCCAGCGCGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACTGCGACCCTCGGTGCCTATGCCGCGGTCAAGGGGGGCTTTGAGCTGGATGACAAGGTGAGCCAGCACGCCCCCTGGCTCAAAGGTTCCGCCTTGGATGGTGTGACCATGGCCGAGCTTGCCACCTACAGTGCGGGTGGTTTGCCGCTGCAGTTCCCCGATGAGGTGGATTCGAATGACAAGATGCGCACTTACTATCGGAGCTGGTCACCGGTTTATCCGGCGGGGACCCATCGCCAGTATTCCAACCCCAGCATCAGCCTGTTTGGTCACCTGGCCGCAAATAGTCTGGGCCAGCCATTTGAGCAACTGATGAGCCAGACCCTGCTGCCCAAGCTGGGTTTGCACCACACCTATATCCAGGTACCGGAGTCGGCTATGGTGAACTATGCCTACGGCTATTCGAAGGAAGATAAGCCCGTCCGGGTCACTCCGGGCGTGCTGGCAGCCGAGGCTTACGGGATCAAGACCGGCTCGGCGGATCTGCTGAAGTTTGCCGAGGCAAACATGGGGTATCAGGGAGATGCCGCGGTAAAAAGCGCGATCGCGCTGACCCACACCGGTTTCTACTCGGTGGGAGACATGACCCAGGGACTGGGCTGGGAGAGTTACGCCTATCCGGTGACCGAGCAGACATTGCTGGCGGGTAACGCACCGGCGGTGAGCTTCCAGGCCAATCCGGTTACGCGCTTTGCGGTGCCCAAGGCGATGGGCGAGCAGCGGCTCTATAACAAGACGGGCTCGACTGGCGGCTTTGGCGCCTATGTGGCGTTCGTGCCCGCCAGAGGGATCGCCATCGTCATGCTGGCCAATCGCAACTATCCCATCGAGGCCAGGGTGAAGGCGGCTCACGCCATCCTGAGTCAGTTGGCCGAGTGA", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 50.86}, "gnl|BL_ORD_ID|2163|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2329", "ARO_accession": "3002191", "ARO_name": "MOX-9", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.56454e-76, "max_identities": 121, "bit_score": 235.343, "cvterm_id": "36915", "query": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M   +++TL+ A LA  A   + AD +  +VD++I+P++ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V S   +  +Y+QW P+ + G  R Y+N SIGLFG L A + G P+EQL++  +L  LGL HT++ VP  A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L++   NM", "sequence_from_db": "MTLLMASTLLWAGLA-QATADTQADPLRPLVDASIRPVLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGARVSEQTLFEIGSVSKTLTATLGAYAVVKGALKLDDKVSQHGPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSIDKMRAYYRQWTPAYRAGSHRQYSNPSIGLFGHLAAQSLGQPFEQLMSQTLLPGLGLEHTYLKVPAEAMANYAYGYSKEDKPIRVNPGVLADEAYGIKTSSADLLKFVGANM", "sequence_from_broadstreet": "MQQQVRMTLLMASTLLWAGLAQATADTQADPLRPLVDASIRPVLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGARVSEQTLFEIGSVSKTLTATLGAYAVVKGALKLDDKVSQHGPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSIDKMRAYYRQWTPAYRAGSHRQYSNPSIGLFGHLAAQSLGQPFEQLMSQTLLPGLGLEHTYLKVPAEAMANYAYGYSKEDKPIRVNPGVLADEAYGIKTSSADLLKFVGANMTGTGDEAMQQAIALTHKGVYSVGAMTQGLGWESYAYPVTEETLLAGNSGKVILEANPTAPASNETGSQVLFNKTGSTGGFGAYVAFVPAKGIGIVMLANRNYPIQARVETAHAILSKLAE", "dna_sequence_from_broadstreet": "ATGCAACAACAGGTGCGGATGACATTGCTGATGGCGAGCACGCTGCTCTGGGCCGGTCTGGCCCAGGCCACGGCGGACACCCAGGCCGATCCCCTGCGCCCCCTGGTGGATGCCAGTATCCGGCCCGTGCTCAAGGAGCACCGGATCCCCGGCATGGCGGTGGCGGTGCTGAAAGATGGCAAGGCCCACTACTTCAACTACGGGGTGGCCAACCGGGAGAGCGGGGCCCGTGTCAGCGAGCAGACCCTGTTCGAGATTGGATCGGTCAGCAAGACTCTTACGGCAACGCTTGGGGCTTATGCCGTGGTGAAGGGGGCGCTCAAGCTCGATGACAAGGTGAGTCAGCATGGGCCCTGGCTGAAAGGATCGGCTTTTGACGGTATCACCATGGCCGAGCTCGCCACCTACAGCGCCGGGGGCTTGCCGCTGCAATTCCCCGACGAGGTGGATTCCATCGACAAGATGCGTGCCTACTATCGCCAGTGGACGCCTGCCTATCGGGCGGGCAGCCATCGCCAGTACTCCAACCCCAGCATCGGCCTGTTCGGCCATCTCGCGGCCCAGAGCCTGGGCCAACCCTTTGAACAGTTGATGAGCCAGACCCTGCTGCCCGGGCTTGGTCTCGAGCACACCTATCTCAAGGTCCCTGCCGAGGCCATGGCGAACTACGCCTATGGCTACTCGAAAGAGGACAAGCCTATCAGGGTCAACCCGGGGGTCCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGAAGTTTGTCGGCGCCAACATGACAGGCACCGGGGACGAGGCGATGCAGCAGGCGATTGCCCTGACCCACAAGGGGGTTTACTCGGTGGGTGCCATGACTCAGGGGCTCGGCTGGGAGAGTTATGCCTATCCCGTGACCGAAGAGACCTTGCTTGCAGGCAACTCGGGCAAGGTGATCCTCGAGGCCAACCCGACGGCGCCCGCCTCCAACGAGACGGGTAGCCAGGTGCTCTTCAACAAGACCGGCTCCACCGGCGGCTTTGGTGCCTATGTGGCCTTTGTGCCAGCCAAGGGGATTGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCAGGCCAGGGTAGAGACGGCCCACGCCATCCTGAGCAAGCTGGCCGAGTGA", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.9}, "gnl|BL_ORD_ID|2212|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "AQU-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3347", "ARO_accession": "3004648", "ARO_name": "AQU-3", "ARO_category": {"39426": {"category_aro_accession": "3002992", "category_aro_cvterm_id": "39426", "category_aro_name": "AQU beta-lactamase", "category_aro_description": "AQU beta-lactamases are chromosomal class C beta-lactamases that confer resistance to cephalosporins.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.99135e-75, "max_identities": 114, "bit_score": 234.187, "cvterm_id": "39651", "query": "ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "AD +  VVD  I+PL+ +  IPGMAVAV   G+ +YFNYG A++   + V+E TLFE+GSVSKT T  LGA +V K  + L+D  +++ P L    + GIT+ +LATY+AGGLPLQ PD V+S   +  +Y+QW P+ +PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT+I VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ADPLVGVVDDVIRPLVKEHRIPGMAVAVLKGGQAHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MKQTSPLSLLALSALLLSPLTQAAPADPLVGVVDDVIRPLVKEHRIPGMAVAVLKGGQAHYFNYGVAELATGKKVSEQTLFEIGSVSKTLTATLGAYAVVKGSIGLDDKVSRHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVESLEQMQAYYRQWTPAYQPGSHRQYSNPSIGLFGYLAASSLQQPFAQLMEQTLLPGLGLHHTYINVPKQAMANYAYGYSKEDKPIRVTPGVLADEAYGIKTSSADLLAFVKANINGVDDKGLQQAIALTHQGHYSVGGMTQGLGWESYPYPVSEQTLQVGNSREVSFKGNPVKGFKAPVTFGEARLYNKTGSTNGFGAYVAFVXAKGVGIVMLANRNYPIQERVKAAHAILSKLAP", "dna_sequence_from_broadstreet": "ATGAAGCAAACCTCACCCTTGTCGTTGCTGGCGCTGAGCGCCCTGCTGCTGTCGCCCCTCACCCAGGCCGCTCCCGCCGATCCGCTGGTCGGGGTAGTGGATGACGTCATTCGTCCGCTGGTGAAAGAGCACAGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGGGGGGCAGGCCCACTACTTCAACTACGGGGTTGCCGAGCTGGCAACGGGGAAGAAGGTCAGCGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCCTGACCGCGACCCTGGGGGCCTACGCCGTGGTCAAGGGGAGCATTGGGCTGGATGACAAGGTGAGCCGGCACGCTCCCTGGCTCAAGGGCTCCGCCTTTGATGGCATTACCATGGCCGAGCTTGCCACTTACAGTGCCGGGGGCCTGCCGCTGCAATTCCCCGACGAGGTGGAATCGCTCGAGCAGATGCAGGCTTACTATCGCCAGTGGACGCCGGCCTATCAACCAGGCAGCCATCGCCAGTACTCCAACCCCAGTATCGGCCTGTTCGGCTATCTGGCGGCGAGCAGTCTGCAGCAGCCGTTTGCCCAGTTGATGGAGCAGACCCTGCTGCCAGGGCTCGGCCTGCATCACACCTATATCAATGTGCCTAAGCAGGCGATGGCGAACTACGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCACGCCAGGGGTGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCAACGGGGTGGATGACAAGGGGTTGCAGCAGGCCATCGCTTTGACCCACCAGGGGCACTACTCGGTAGGCGGGATGACTCAGGGGCTGGGCTGGGAGAGCTACCCCTATCCAGTCAGTGAGCAGACGCTGCAGGTTGGGAACTCCCGCGAGGTGAGTTTCAAGGGCAATCCTGTCAAAGGATTCAAGGCGCCGGTTACATTTGGTGAGGCGCGGCTCTACAACAAGACCGGCTCGACCAACGGCTTTGGCGCCTATGTGGCCTTCGTGCMGGCCAAGGGAGTGGGCATCGTCATGCTGGCCAACCGCAACTACCCCATCCAGGAGAGGGTAAAGGCGGCCCACGCCATCCTGAGCAAGCTGGCTCCCTGA", "partial": "0", "query_start": 1915, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.51}, "gnl|BL_ORD_ID|1396|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1485", "ARO_accession": "3002190", "ARO_name": "MOX-8", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.09297e-75, "max_identities": 122, "bit_score": 234.187, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGDK-AATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSPAMIYNANPAAPAPAAAGHPVLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTTTGGCCACCCTGATGTGGGCCGGTCTGGCTCATGCCGGTGACAAGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCGGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCATGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGAGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAACTCCCCGGCGATGATTTACAATGCCAACCCGGCGGCGCCCGCGCCCGCTGCGGCAGGGCACCCTGTGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.41}, "gnl|BL_ORD_ID|646|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "688", "ARO_accession": "3002183", "ARO_name": "MOX-2", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.63961e-75, "max_identities": 122, "bit_score": 233.417, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGE-TSPVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGETSPVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVHDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTCTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGACTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCATGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTCATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGAGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGATGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.41}, "gnl|BL_ORD_ID|1403|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1492", "ARO_accession": "3002186", "ARO_name": "MOX-3", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.0742e-75, "max_identities": 122, "bit_score": 232.646, "cvterm_id": "36942", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSK  T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R Y+N SIGLFG L A++   P+ QL+   +L  LGL HT++ VP+ A + YAYGY K  KP+RVSPG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGE-TSPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGETSPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWERYAYPVSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGACTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGCCCCTGACCGCGACCCTAGGAGCCTATGCGGTGGTCAAGGGAGCGATGCAACTGGATGACAAGGCGAGCCGGCACGCCCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACTCTAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCAGTTGATGGAGCAGACGCTCCTGCCGGGGCTTGGCCTGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCAGGGTCAGCCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAAACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCACTACTCGGTAGGCGGGATGACCCAGGGACTGGGTTGGGAGCGTTACGCCTATCCCGTCAGCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGATGCTCTTCAACAAGACCGGCTCGACCAGCGGCTTCGGCGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAACCGCAACTATCCTATCCCGGCCAGGGTGAAAGCGGCCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.41}, "gnl|BL_ORD_ID|1542|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1637", "ARO_accession": "3002189", "ARO_name": "MOX-7", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.14956e-75, "max_identities": 121, "bit_score": 232.261, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A L  +    +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSKT T  LGA +V +    L+D A+ + P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R YAN SIGLFG L A++   P+++L+   +L  LGL HT++TVPE A   YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLVHAGDK-AATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLTVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLVHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLTVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANIGGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYPVSEQTLLAGNSPAMIYNAIPAVPAPAAAGHPVLFNKTGSTNGFGAYVAFVPAKGIGIVMLANRNSPIEARIKAAHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTCTGGCCACCTTGATGTGGGCCGGCTTGGTTCATGCCGGTGACAAGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGTTCCGTGAGCAAGACCCTGACCGCGACGCTGGGGGCCTACGCCGTGGTGCAGGGGAGCTTCGAGCTCGATGACAAGGCGAGTCTGTTCGCCCCCTGGCTCAAGGGATCCGTCTTTGACAACATCACCATGGGGGAGCTGGCTACCTACAGCGCAGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACTCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACGCCAACCCCAGCATCGGGCTCTTTGGCTATCTGGCGGCGAGCAGCATGAAGCAGCCGTTCGATCGCCTGATGGAGCAGACGATGCTGCCGGGGCTAGGCCTGTACCATACTTACCTCACTGTGCCCGAGCAGGCCATGGGGCACTACGCCTACGGCTACTCGAAGGAGGACAAGCCGATCCGCGTCACTCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGTTCGGCGGATCTGCTGCGCTTTGTGAAGGCGAACATCGGCGGGGTGGATAATGCGGCCATGCAGCAGGCCATCGACCTGACTCACCAGGGCCAGTATGCGGTGGGGGAGATGACCCAGGGACTGGGCTGGGAGCGTTACGCCTATCCCGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCCCGGCGATGATTTACAATGCCATCCCGGCTGTGCCCGCGCCCGCTGCGGCAGGCCACCCTGTGCTTTTCAACAAGACCGGCTCGACCAATGGCTTCGGGGCTTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAATCGCAACTCTCCCATCGAGGCGCGCATCAAGGCGGCTCACGCAATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.02}, "gnl|BL_ORD_ID|1290|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1376", "ARO_accession": "3002185", "ARO_name": "MOX-6", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.14705e-74, "max_identities": 122, "bit_score": 232.261, "cvterm_id": "36936", "query": "TLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "TL+ A LA  A   +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSKT T  LGA +V +    L+D A+ + P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+  PG  R YAN SIGLFG L A++   P+++L+   IL  LGL HT++ VPE A   YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "TLMWAGLA-HAGDRAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTILPGLGLYHTYLNVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGVLPTLMWAGLAHAGDRAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTILPGLGLYHTYLNVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYPVSEQTLLAGNSAAMIYNANPAAPAPAARGHPVLFNKTGSTNGFGAYVAFVPAKGIGIVMLANRNSPIEGTLKAGHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGTTCTGCCCACCCTGATGTGGGCCGGCCTGGCCCATGCAGGTGACAGGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCAGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGTTCCGTGAGCAAGACCCTGACCGCGACGCTGGGGGCCTACGCCGTGGTGCAGGGGAGCTTCGAGCTCGATGACAAGGCGAGTCTGTTCGCCCCCTGGCTCAAGGGATCCGTCTTTGACAACATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCCGGGTTCCCATCGCCAGTACGCCAACCCCAGCATCGGGCTCTTTGGCTATCTGGCGGCGAGCAGCATGAAGCAGCCGTTCGATCGCCTGATGGAGCAGACGATCCTGCCGGGGCTTGGCCTGTACCATACCTACCTCAATGTGCCCGAGCAGGCCATGGGGCACTACGCCTACGGCTACTCGAAGGAGGACAAGCCCATCCGCGTCACTCCCGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTTGTGAAGGCCAACATCAGCGGGGTGGATAATGCGGCCATGCAGCAGGCCATCGACCTGACTCACCAGGGGCAGTATGCGGTGGGGGAGATGACCCAGGGACTGGGCTGGGAGCGTTACGCCTATCCCGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCGCGGCGATGATTTACAATGCGAACCCGGCTGCGCCCGCGCCCGCTGCAAGGGGGCACCCTGTGCTCTTCAACAAGACCGGCTCGACCAACGGCTTCGGGGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCATCGTCATGCTGGCCAATCGCAACTCTCCCATCGAGGGCACGCTCAAGGCGGGCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1867, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 48.61}, "gnl|BL_ORD_ID|249|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "269", "ARO_accession": "3002019", "ARO_name": "CMY-8", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.28369e-73, "max_identities": 119, "bit_score": 229.565, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|986|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1049", "ARO_accession": "3002182", "ARO_name": "MOX-1", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.29758e-73, "max_identities": 119, "bit_score": 229.565, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGAGCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|1289|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1375", "ARO_accession": "3002022", "ARO_name": "CMY-11", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.44499e-73, "max_identities": 119, "bit_score": 229.18, "cvterm_id": "35914", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+  L+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTACTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCGGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCCCTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGTGTCAACCCTGGCATGCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGCGTTTTGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACCAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGAGCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTACCCCATCGAGGCGCGCATCAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|15|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "20", "ARO_accession": "3002012", "ARO_name": "CMY-1", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.52486e-73, "max_identities": 119, "bit_score": 229.18, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+  L+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPNEARIKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTACTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCGGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCCCTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGTGTCAACCCTGGCATGCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGCGTTTTGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACCAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTACCCCAACGAGGCGCGCATCAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|766|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "812", "ARO_accession": "3002021", "ARO_name": "CMY-10", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.59192e-73, "max_identities": 119, "bit_score": 229.18, "cvterm_id": "36770", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLFE+GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+  L+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTACTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCGGCGTCAGCGAGCAGACCCTGTTCGAGATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGCCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCGTTTGCCCCCTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGTGTCAACCCTGGCATGCTGGCGGACGAGGCCTATGGCATCAAGACCAGCTCGGCGGATCTGCTGCGTTTTGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACCAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCGCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTACCCCATCGAGGCGCGCATCAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.22}, "gnl|BL_ORD_ID|121|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "136", "ARO_accession": "3002020", "ARO_name": "CMY-9", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.08793e-73, "max_identities": 118, "bit_score": 228.024, "cvterm_id": "35914", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLF++GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGATATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGATCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.83}, "gnl|BL_ORD_ID|1059|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CMY-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1129", "ARO_accession": "3002030", "ARO_name": "CMY-19", "ARO_category": {"36208": {"category_aro_accession": "3000069", "category_aro_cvterm_id": "36208", "category_aro_name": "CMY beta-lactamase", "category_aro_description": "CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.42714e-73, "max_identities": 118, "bit_score": 227.639, "cvterm_id": "35915", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    S  D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG A+ ++   V+E TLF++GSVSKT T  LGA +V K  M L+D A+++ P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P   PG  R Y+N SIGLFG L A++   P+ QL+   +L  LG+ HT++ VP+ A + YAYGY K  KP+RV+PG L  E+YG+K++S D+L + + N+", "sequence_from_db": "ATLMWAGLAHAGEA-SPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANI", "sequence_from_broadstreet": "MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGGGCCGTGGCCACCCTGATGTGGGCCGGTCTGGCCCATGCAGGTGAGGCTTCACCGGTCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCAGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAATTACGGGGTGGCCAACCGGGAGAGCGGGGCCAGCGTCAGCGAGCAGACCCTGTTCGATATAGGATCCGTGAGCAAGACCCTGACTGCGACCCTGGGGGCCTATGCGGTGGTCAAGGGAGCGATGCAGCTGGATGACAAGGCGAGCCGGCACGCGCCCTGGCTCAAGGGATCCGTCTTTGACAGCATCACCATGGGGGAGCTTGCCACCTACAGCGCCGGAGGCCTGCCACTGCAATTCCCCGAGGAGGTGGATTCATCCGAGAAGATGCGCGCCTACTACCGCCAGTGGGCCCCTGTCTATTCGCCGGGCTCCCATCGCCAGTACTCCAACCCCAGCATAGGGCTGTTCGGCCACCTGGCGGCGAGCAGCCTGAAGCAGCCATTTGCCCAGTTGATGGAGCAGACCCTGCTGCCCGGGCTCGGCATGCACCACACCTATGTCAATGTGCCGAAGCAGGCCATGGCGAGTTATGCCTATGGCTATTCGAAAGAGGACAAGCCCATCCGGGTCAACCCTGGCATGCTGGCGGACGAGGCCTACGGCATCAAGACCAGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAACATCGGCGGGGTTGATGACAAGGCGTTGCAGCAGGCCATCTCCCTGACCCACAAAGGGCATTACTCGGTAGGCGGGATGACCCAGGGGCTGGGTTGGGAGAGTTACGCCTATCCCGTCACCGAGCAGACATTGCTGGCGGGCAATTCGGCCAAGGTGAGCCTCGAAGCCAATCCGACGGCGGCTCCCCGGGAGTCGGGGAGCCAGGTGCTCTTCAACAAGACCGGCTCGACCAATGGCTTTGGCGCCTATGTGGCCTTCGTGCCGGCCAGGGGGATCGGCATCGTCATGCTGGCCAATCGCAACTATCCCATCCCGGCCAGGGTGAAGGCGGCCCACGCCATCCTGGCGCAGTTGGCCGGTTGA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.83}, "gnl|BL_ORD_ID|2570|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "TRU-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2889", "ARO_accession": "3004450", "ARO_name": "TRU-1", "ARO_category": {"41644": {"category_aro_accession": "3004449", "category_aro_cvterm_id": "41644", "category_aro_name": "TRU beta-lactamase", "category_aro_description": "A class C beta-lactamase endogenous to Aeromonas enteropelogenes (tructi)", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.79088e-72, "max_identities": 112, "bit_score": 226.483, "cvterm_id": "41646", "query": "FSAADN-VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPS", "match": "++AAD  +A +V+  ++PL+ +  IPGMAVAV  +GKP+YFNYG A+ ++ + ++E TLFE+GSVSKTFT  LG  +V K    L+D  +++ P L    +  +T+  LATY+AGGLPLQ PDAV S   +  +Y+QW P    G  R Y+N SIGLFG L A+  G P+ QL++  +L  L L HT++ VP++A   YAYGY K  KPVRV+PG L  E+YG+K+++ D++++   NM  S", "sequence_from_db": "YAAADEPMANIVEKAVQPLLEEYRIPGMAVAVLKEGKPHYFNYGVANRESGRRISERTLFEIGSVSKTFTATLGTYAVVKGGFRLDDKVSQHAPWLQNSAFDRVTMAQLATYSAGGLPLQFPDAVDSNERMRQYYRQWSPLYAAGTHREYSNPSIGLFGHLAASTLGQPFRQLMSQTLLPKLDLQHTYLEVPDAAMVDYAYGYSKEDKPVRVNPGVLADEAYGIKTSAADLIKFVGANMTGS", "sequence_from_broadstreet": "MKQRIALSLLALGPLLLVPRVYAAADEPMANIVEKAVQPLLEEYRIPGMAVAVLKEGKPHYFNYGVANRESGRRISERTLFEIGSVSKTFTATLGTYAVVKGGFRLDDKVSQHAPWLQNSAFDRVTMAQLATYSAGGLPLQFPDAVDSNERMRQYYRQWSPLYAAGTHREYSNPSIGLFGHLAASTLGQPFRQLMSQTLLPKLDLQHTYLEVPDAAMVDYAYGYSKEDKPVRVNPGVLADEAYGIKTSAADLIKFVGANMTGSGDKAVQQALAMTRTGFYSVGEMTQGLGWESYAYPVTEQALLAGNSPAVSFKANPVKPFVAPRVMGNERLYNKTGSTNGFGAYVVFVPARGVGIVMLANRNYPIEARVKAAYAIMRHLAP", "dna_sequence_from_broadstreet": "ATGAAACAACGAATCGCGCTATCACTGCTGGCATTGGGGCCCCTGTTGCTCGTCCCACGCGTTTATGCCGCGGCAGATGAGCCCATGGCGAACATAGTGGAAAAGGCTGTCCAGCCGCTGCTGGAGGAGTACCGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGAGGGCAAGCCTCACTACTTCAATTATGGCGTCGCCAATCGGGAGAGCGGCCGGCGCATCAGCGAGCGGACCCTGTTCGAGATTGGTTCGGTCAGCAAGACCTTTACTGCGACCTTGGGCACCTACGCGGTCGTCAAAGGGGGCTTTCGGCTGGATGACAAGGTGAGCCAGCACGCGCCTTGGTTGCAGAATTCGGCGTTTGATCGCGTCACCATGGCCCAGCTGGCGACCTACAGCGCAGGGGGCTTGCCGTTGCAGTTTCCCGATGCGGTCGACTCAAACGAGAGAATGCGCCAGTACTACCGGCAGTGGTCACCGCTTTATGCGGCAGGCACTCATCGCGAGTACTCCAACCCCAGCATAGGTCTGTTCGGCCATCTGGCGGCGAGCACCCTGGGCCAACCATTCAGACAACTGATGAGCCAGACTCTGCTGCCCAAGCTCGATTTGCAGCACACCTATCTCGAGGTGCCAGACGCAGCCATGGTTGACTACGCCTATGGCTATTCGAAGGAAGACAAACCCGTCAGGGTCAATCCCGGAGTGCTGGCGGACGAAGCCTATGGCATCAAGACCAGCGCGGCGGATCTCATCAAGTTTGTGGGCGCCAACATGACAGGCAGTGGCGACAAGGCGGTGCAGCAAGCGCTGGCCATGACCCGTACCGGTTTCTACTCGGTGGGAGAGATGACCCAGGGGCTGGGGTGGGAGAGCTACGCCTATCCCGTGACCGAACAGGCGCTGCTGGCGGGCAATTCACCGGCGGTGAGCTTCAAGGCCAATCCGGTCAAACCCTTTGTGGCTCCCAGAGTGATGGGGAACGAGCGACTCTACAACAAGACAGGCTCGACCAACGGCTTTGGTGCCTATGTGGTGTTTGTCCCGGCCAGAGGCGTGGGCATCGTCATGCTGGCCAATCGCAACTACCCCATCGAGGCCAGGGTCAAGGCTGCCTATGCCATCATGCGCCATCTGGCACCCTGA", "partial": "0", "query_start": 1906, "query_end": 2625, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.28}, "gnl|BL_ORD_ID|278|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "CepS beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "299", "ARO_accession": "3003553", "ARO_name": "CepS", "ARO_category": {"41363": {"category_aro_accession": "3004199", "category_aro_cvterm_id": "41363", "category_aro_name": "CepS beta-lactamase", "category_aro_description": "CepS beta-lactamases are Class C beta-lactamases capable of hydrolyzing cephalosporin.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.97165e-72, "max_identities": 111, "bit_score": 224.942, "cvterm_id": "36957", "query": "DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "D + AVVD  I+P++ Q  IPGMAVAV   G+ +YFNYG AD+     V E TLFE+GSVSKT+T  LGA +V K    L+D  + + P L    + GIT+ +LATY+AGGLPLQ PD V S   +  +Y+ W P  + G  R Y+N SIGLFG L A++   P+  L+   +L  LGL HT++ VPE+A ++YA+GY K  KP+RV+PG L  E+YG+K+ S D+L + + N+", "sequence_from_db": "DPLKAVVDDAIRPVLKQHRIPGMAVAVLKGGQAHYFNYGLADVATGAKVNEQTLFEIGSVSKTYTATLGAYAVVKGGFKLDDQVSGHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSSDTMRAYYRHWTPPYQAGTQRQYSNPSIGLFGHLAASSLQQPFSTLMEQTLLPALGLEHTYLQVPEAAMARYAFGYSKEDKPIRVNPGMLADEAYGIKTGSADLLAFVKANI", "sequence_from_broadstreet": "MKQTRALPLLALGTLLLAPLSLAAPVDPLKAVVDDAIRPVLKQHRIPGMAVAVLKGGQAHYFNYGLADVATGAKVNEQTLFEIGSVSKTYTATLGAYAVVKGGFKLDDQVSGHAPWLKGSAFDGITMAELATYSAGGLPLQFPDEVDSSDTMRAYYRHWTPPYQAGTQRQYSNPSIGLFGHLAASSLQQPFSTLMEQTLLPALGLEHTYLQVPEAAMARYAFGYSKEDKPIRVNPGMLADEAYGIKTGSADLLAFVKANISGVDDKALQQAIALTHTGFYRIGEMSQGLGWESYAYPVSEQTLLAGNSPAVSLKANPVTKFETPAAPGAMRLYNKTGSTGGFGAYVAFVPAKGIGIVMLANRNYPIEARVSAAHAILSQLAP", "dna_sequence_from_broadstreet": "ATGAAACAGACCAGAGCCCTGCCACTGCTGGCCCTCGGCACCCTGCTGCTTGCCCCGCTCTCCCTGGCGGCCCCCGTCGATCCGCTGAAGGCGGTGGTGGATGACGCCATCCGCCCCGTGCTCAAGCAGCACAGGATCCCGGGCATGGCGGTCGCCGTGCTGAAGGGGGGGCAGGCCCACTACTTCAACTACGGGCTGGCCGATGTGGCGACCGGGGCCAAGGTCAATGAGCAGACCCTGTTCGAGATTGGCTCGGTCAGCAAGACCTATACCGCCACCCTTGGCGCCTACGCCGTGGTCAAGGGGGGCTTCAAGCTCGATGACCAGGTGAGCGGGCACGCACCCTGGCTCAAGGGCTCCGCCTTCGATGGCATCACCATGGCGGAACTTGCCACCTACAGTGCCGGGGGGCTGCCGCTGCAATTCCCCGACGAGGTTGATTCGAGCGATACCATGCGGGCCTATTACCGGCACTGGACGCCGCCATATCAGGCGGGAACCCAGCGCCAATACTCCAATCCCAGCATCGGCCTGTTCGGCCATCTGGCGGCGAGCAGCCTGCAGCAGCCGTTTTCCACGTTGATGGAGCAGACCCTGCTGCCAGCACTCGGGTTGGAGCACACCTATCTGCAGGTGCCCGAGGCCGCCATGGCTCGCTACGCCTTCGGCTACTCGAAGGAGGACAAACCCATCAGGGTCAACCCTGGCATGCTGGCCGACGAGGCCTACGGCATCAAGACCGGCTCGGCGGATCTGCTCGCCTTCGTGAAGGCCAATATCAGCGGGGTTGATGACAAGGCGTTGCAACAGGCGATCGCCCTGACCCACACCGGTTTTTATCGGATAGGGGAGATGAGCCAGGGGCTGGGCTGGGAGAGCTACGCCTACCCGGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCCCGGCGGTGAGCCTCAAGGCCAATCCGGTCACTAAGTTCGAGACGCCAGCCGCGCCCGGGGCTATGCGCCTCTACAACAAGACCGGGTCGACCGGTGGCTTCGGCGCCTACGTGGCCTTCGTGCCCGCCAAAGGGATCGGCATCGTCATGCTGGCCAATCGCAATTATCCCATCGAGGCCAGAGTCAGCGCGGCCCATGCCATTTTGAGCCAGCTGGCACCCTGA", "partial": "0", "query_start": 1918, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 47.44}, "gnl|BL_ORD_ID|43|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "MOX-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "53", "ARO_accession": "3002188", "ARO_name": "MOX-5", "ARO_category": {"36222": {"category_aro_accession": "3000083", "category_aro_cvterm_id": "36222", "category_aro_name": "MOX beta-lactamase", "category_aro_description": "MOX beta-lactamases are plasmid-mediated AmpC-type beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.84564e-70, "max_identities": 118, "bit_score": 220.705, "cvterm_id": "36936", "query": "ATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "ATL+ A LA +    +A D +  VVD++I+PL+ +  IPGMAVAV   GK +YFNYG AD +    V+E TLFE+GSVSKT T  LGA +V +    L+D A+ + P L    +  IT+ +LATY+AGGLPLQ P+ V S   +  +Y+QW P+   G  R YAN SIGLFG L A++   P+++L+   +L  LGL HT++ VPE     YAYGY K  KP RV+P  L  E YG+K++S D+LR+ + N+", "sequence_from_db": "ATLMWAGLAHAGDK-AATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGGFELDDKASLFAPWLKGSAFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSRGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLNVPEQPMGHYAYGYWKEDKPFRVTPAMLAEEPYGIKTSSADLLRFVKANI", "sequence_from_broadstreet": "MQQRQSILWGALATLMWAGLAHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGGFELDDKASLFAPWLKGSAFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSRGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLNVPEQPMGHYAYGYWKEDKPFRVTPAMLAEEPYGIKTSSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYPYPVSEQTLLAGNSPAMIYNANPAAPAPAAAGHPVLFKKTGSTNGFGAYVAFVPAKGIGVVMLANRNYPNEGTLKAGHAILTQLAR", "dna_sequence_from_broadstreet": "ATGCAACAACGACAATCCATCCTGTGGGGCGCTCTGGCCACCCTGATGTGGGCCGGTTTGGCCCATGCCGGTGACAAGGCGGCGACCGATCCCCTGCGCCCCGTGGTGGATGCCAGCATCCGGCCGCTGCTCAAGGAGCACAGGATCCCGGGCATGGCGGTGGCCGTGCTCAAGGATGGCAAGGCCCACTATTTCAACTACGGTGTGGCCGATCGGGAGCGCGCGGTCGGTGTCAGCGAGCAGACCCTGTTCGAGATAGGCTCCGTGAGCAAGACCCTGACCGCGACGCTGGGGGCCTACGCCGTGGTGCAGGGGGGCTTCGAGCTCGATGACAAGGCGAGTCTGTTCGCCCCCTGGCTCAAGGGATCCGCCTTTGACAACATCACCATGGGGGAGCTGGCTACCTACAGCGCGGGCGGCTTGCCGCTGCAATTCCCCGAGGAGGTGGATTCGCTCGAGAAGATGCAGGCCTACTACCGCCAGTGGACCCCAGCCTACTCGCGGGGTTCCCATCGCCAGTACGCCAACCCCAGCATCGGGCTTTTTGGCTATCTGGCGGCGAGCAGCATGAAGCAGCCGTTCGATCGCTTGATGGAGCAGACGATGCTGCCGGGGCTTGGCCTGTACCATACCTACCTCAATGTGCCCGAGCAGCCCATGGGGCACTACGCCTACGGTTACTGGAAGGAGGACAAGCCATTCCGCGTCACTCCCGCCATGCTGGCGGAGGAGCCTTACGGCATCAAGACCAGCTCGGCGGATCTGCTGCGCTTCGTGAAGGCGAACATCAGCGGGGTGGATAATGCGGCCATGCAGCAGGCCATCGATCTGACTCACCAGGGCCAGTATGCGGTGGGGGAGATGACCCAGGGACTGGGCTGGGAGCGTTACCCCTATCCCGTCAGCGAGCAGACGCTGCTGGCGGGCAACTCCCCGGCGATGATTTACAATGCCAACCCGGCGGCGCCCGCGCCCGCTGCGGCAGGGCACCCTGTGCTCTTCAAAAAGACCGGCTCGACCAATGGCTTCGGGGCCTATGTGGCCTTCGTGCCGGCCAAAGGGATCGGCGTCGTCATGCTGGCCAATCGCAACTACCCCAACGAGGGCACGCTCAAGGCGGGCCACGCCATCCTGACGCAACTGGCCAGGTAA", "partial": "0", "query_start": 1864, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.83}, "gnl|BL_ORD_ID|2201|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2341", "ARO_accession": "3003854", "ARO_name": "ADC-8", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.35412e-69, "max_identities": 107, "bit_score": 219.55, "cvterm_id": "41144", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEP", "match": "VD   KPLMAQ  I GMA+AVS+ G+ YY NYG A  Q +Q V+E+TLFELGSVSK F   L   + A+ ++ L+D  A+Y PEL        TLL+L TYTAGG PLQ P+ +K+  D+  ++Q WQP   P  +R Y+N SIGL G +TA A    Y  L+   +   LG+ H++I VP +  S YA+GY+  + +RVSPG  DAE+YG+KS + DML++ +  + P", "sequence_from_db": "VDRHFKPLMAQYQISGMAIAVSINGQHYYQNYGVASKQTEQNVSEHTLFELGSVSKLFNATLTGYAQAQGQLKLSDHPAQYFPELKNTAVNQATLLNLGTYTAGGFPLQFPEQIKTTQDMTQYFQHWQPKAAPRRIREYSNPSIGLMGYVTALAMKNSYSNLIENTLFPALGMHHSYINVPAAQMSNYAWGYQADQAIRVSPGMFDAEAYGIKSNTADMLKFLDAQINP", "sequence_from_broadstreet": "MMKDILGNLDNVPFKIMTGCIAGLLSCGTVAQSTVQQSIQQSVDRHFKPLMAQYQISGMAIAVSINGQHYYQNYGVASKQTEQNVSEHTLFELGSVSKLFNATLTGYAQAQGQLKLSDHPAQYFPELKNTAVNQATLLNLGTYTAGGFPLQFPEQIKTTQDMTQYFQHWQPKAAPRRIREYSNPSIGLMGYVTALAMKNSYSNLIENTLFPALGMHHSYINVPAAQMSNYAWGYQADQAIRVSPGMFDAEAYGIKSNTADMLKFLDAQINPQNLKPTLRKAIQTTQMGYFRVGQMRQGLGWEQYTYPVSLTTLLAGNSAKMALQPQPVTGISKPITAPQQALLNKTGATNGFSAYVVVIPSQKIGLVMLANRNFPNDARVKAAYATLQQILNADIQK", "dna_sequence_from_broadstreet": "ATGATGAAAGACATATTAGGTAACTTAGATAACGTGCCATTTAAGATCATGACAGGCTGTATTGCAGGACTATTGTCCTGTGGTACGGTCGCTCAATCGACAGTCCAACAATCAATTCAACAAAGTGTAGATCGACATTTTAAGCCCCTTATGGCTCAGTATCAAATTTCAGGAATGGCGATTGCGGTCAGCATAAATGGGCAACATTACTATCAGAATTATGGCGTAGCATCTAAACAGACCGAGCAAAATGTCTCTGAACATACTCTATTTGAGTTGGGTTCGGTGAGTAAGCTCTTTAATGCAACGCTGACGGGATATGCTCAAGCACAAGGTCAACTTAAGTTGAGTGATCATCCTGCCCAATATTTTCCAGAATTAAAAAATACAGCAGTGAATCAGGCGACTCTCCTGAATCTGGGGACCTATACCGCAGGTGGTTTTCCGCTACAGTTTCCTGAGCAGATCAAGACAACACAAGACATGACTCAGTATTTTCAGCACTGGCAGCCTAAAGCGGCTCCAAGACGTATTCGAGAATATTCAAATCCAAGCATTGGCTTGATGGGCTATGTCACCGCACTTGCGATGAAAAATAGCTATTCAAATCTAATTGAAAATACGTTATTCCCTGCGTTGGGGATGCATCATAGCTATATCAACGTTCCAGCAGCGCAGATGTCAAATTATGCATGGGGATATCAGGCAGATCAGGCGATACGTGTCTCACCAGGTATGTTTGATGCAGAGGCGTATGGCATCAAAAGTAACACTGCCGATATGCTTAAATTTCTAGATGCTCAAATAAATCCCCAAAATCTAAAACCCACGCTCCGAAAGGCCATACAAACCACTCAGATGGGTTATTTTCGGGTGGGACAGATGCGACAGGGCTTGGGTTGGGAGCAATATACTTATCCAGTATCCTTAACAACCTTGCTGGCGGGAAATTCCGCTAAAATGGCTCTACAGCCTCAACCTGTTACAGGCATTTCAAAACCTATCACTGCTCCGCAGCAGGCCCTTTTGAATAAAACTGGTGCAACCAATGGTTTTTCGGCTTATGTGGTGGTTATTCCGAGCCAAAAGATTGGACTGGTGATGCTTGCCAATCGTAATTTTCCCAATGATGCACGGGTGAAAGCAGCTTATGCCACACTACAGCAAATCCTCAATGCAGATATTCAGAAATGA", "partial": "0", "query_start": 1936, "query_end": 2622, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 46.72}, "gnl|BL_ORD_ID|1961|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LRA-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2119", "ARO_accession": "3002489", "ARO_name": "LRA-10", "ARO_category": {"41395": {"category_aro_accession": "3004231", "category_aro_cvterm_id": "41395", "category_aro_name": "class C LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.25991e-69, "max_identities": 113, "bit_score": 217.238, "cvterm_id": "39682", "query": "AADN---VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKN-KKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPV", "match": "AAD+   + A+VD  I+P+MA+ D+PGMAVAV+V G+P+ FNYG A  ++  PV++ TLFELGS+SKTF   L + +    +++L+D   KY P+L        TLL+L TYTAGGLPLQ PD V S   + +++Q W+P   PG  R Y+N S+GLFG LT+ A    +   L   +L  +G+  T++ VP+SA + YA+GY    KP R++PG L    YG++S + DM+R+ + N+ P      G L TPL  +  G  V", "sequence_from_db": "AADDSARIRAIVDQAIRPVMAEHDVPGMAVAVTVDGQPFVFNYGVASRESNTPVSDATLFELGSISKTFAATLASYAQVTGKLSLDDHPGKYMPQLKGSAIDKATLLNLGTYTAGGLPLQFPDDV-SDQQMASYFQHWKPKAAPGVQRTYSNPSLGLFGHLTSLALKSRFTDALETNVLTQMGMKSTYVHVPQSAMANYAWGYDQANKPGRMNPGVLADGIYGIRSTAADMIRYVQANIAP------GKLETPLRRAVEGTHV", "sequence_from_broadstreet": "MAIAILSSCFAPLASRAADDSARIRAIVDQAIRPVMAEHDVPGMAVAVTVDGQPFVFNYGVASRESNTPVSDATLFELGSISKTFAATLASYAQVTGKLSLDDHPGKYMPQLKGSAIDKATLLNLGTYTAGGLPLQFPDDVSDQQMASYFQHWKPKAAPGVQRTYSNPSLGLFGHLTSLALKSRFTDALETNVLTQMGMKSTYVHVPQSAMANYAWGYDQANKPGRMNPGVLADGIYGIRSTAADMIRYVQANIAPGKLETPLRRAVEGTHVGYFKVGGMVQGLGWEQYPYPVSLQQLQAGNSTTMAWEANPAQKLTPPSVPSGATLFNKTGSTSRFGAYVAFVPEKKIGIVILANKNIPGPDRIKAAHAILEQL", "dna_sequence_from_broadstreet": "ATGGCAATCGCCATCCTGTCTTCCTGTTTCGCGCCGCTCGCCAGCCGGGCCGCCGACGACAGCGCCAGGATCCGCGCCATCGTCGACCAGGCGATACGCCCCGTCATGGCCGAACACGACGTGCCGGGCATGGCGGTCGCCGTGACGGTCGACGGCCAACCGTTCGTCTTCAACTATGGCGTCGCCTCGCGCGAGAGCAACACGCCCGTCAGCGACGCGACGCTGTTCGAGCTCGGCTCCATCAGCAAGACTTTTGCCGCCACGCTGGCCTCGTATGCGCAGGTGACCGGCAAGCTGTCGCTGGACGACCATCCCGGCAAGTACATGCCGCAGCTGAAGGGCAGCGCGATCGACAAGGCCACCCTGCTCAATCTGGGCACCTACACGGCGGGCGGACTGCCGCTGCAATTCCCGGACGACGTCTCGGACCAGCAGATGGCCAGCTACTTCCAGCACTGGAAACCGAAGGCCGCGCCCGGCGTACAACGGACCTATTCCAATCCCAGCCTCGGGCTGTTCGGACACCTGACCAGCCTTGCGCTGAAGAGCCGTTTTACCGACGCGCTGGAAACGAATGTCCTCACGCAGATGGGCATGAAGAGCACCTATGTCCACGTGCCACAAAGCGCCATGGCCAATTACGCCTGGGGATACGATCAAGCAAACAAGCCTGGCCGCATGAACCCCGGCGTCCTCGCCGACGGAATCTATGGCATCCGGTCGACAGCCGCCGACATGATCCGCTATGTGCAAGCCAACATCGCCCCGGGCAAGCTGGAAACGCCGTTGCGGCGCGCGGTGGAAGGCACCCATGTCGGCTACTTCAAGGTGGGCGGCATGGTGCAGGGACTCGGCTGGGAGCAATACCCTTACCCGGTCTCCCTGCAGCAGCTACAGGCCGGCAACTCCACCACCATGGCATGGGAAGCCAACCCCGCGCAGAAACTCACGCCGCCGAGCGTACCGTCCGGCGCGACCCTGTTCAACAAGACCGGCTCCACCAGCCGCTTCGGCGCCTACGTGGCGTTCGTGCCGGAGAAGAAAATCGGCATCGTCATCCTCGCGAACAAGAACATCCCGGGTCCGGACCGTATCAAGGCGGCCCATGCGATCCTGGAACAACTGTAA", "partial": "0", "query_start": 1912, "query_end": 2688, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 42.97}, "gnl|BL_ORD_ID|1775|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "SRT-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "1878", "ARO_accession": "3002494", "ARO_name": "SRT-2", "ARO_category": {"36234": {"category_aro_accession": "3000095", "category_aro_cvterm_id": "36234", "category_aro_name": "SRT beta-lactamase", "category_aro_description": "SRT beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.77291e-69, "max_identities": 111, "bit_score": 216.853, "cvterm_id": "36783", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGF", "match": "+D+ I+PLM +  +PGMA+AVSV GK   + YG A  Q  +P+TE TLFE+GS+SKTFT  L   +  + +++ NDPA++Y PEL    + G++LL+LAT+T+ GLPL VPD V + A L+ +Y+ WQP    G  R+Y+N  IG+ G + A +   P+ Q +   +L  LG+SHT++ VP +  + YA GY K+ KPVRV+PG LDAESYG+KS ++D++R+ + N++  +                  P R   +AT VG+", "sequence_from_db": "IDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEETLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTS-GLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKSNARDLIRYLDANLQQVKVAQ---------------PWRDALAATHVGY", "sequence_from_broadstreet": "MTKMNRLAAALIAALILPTAQAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEETLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSGLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKSNARDLIRYLDANLQQVKVAQPWRDALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLANKWFPNDDRVEAAYHIVQALEKR", "dna_sequence_from_broadstreet": "ATGACGAAAATGAACCGCCTGGCGGCCGCGCTGATCGCCGCACTGATCTTGCCGACCGCGCAGGCCGCGCAGCAGCAGGATATCGACGCCGTTATTCAGCCGCTGATGAAAAAATATGGCGTACCGGGCATGGCGATCGCCGTGTCGGTCGACGGCAAACAGCAGATTTACCCGTATGGCGTCGCCTCGAAGCAGACCGGCAAACCGATCACCGAGGAGACGCTGTTCGAAGTGGGCTCGCTGAGCAAAACCTTTACCGCGACGCTGGCGGTCTATGCGCAGCAGCAGGGCAAGCTGTCGTTCAACGATCCGGCCAGCCGCTATCTGCCCGAGCTGCGCGGCAGCGCCTTCGACGGCGTCAGCCTGCTGAATCTGGCGACGCATACCTCCGGCCTGCCGCTGTTCGTGCCGGACGACGTCACTAACGACGCCCAGCTGATGGCCTACTACCGGGCCTGGCAGCCGAAACACCCGGCGGGCAGCTACCGTGTCTATTCCAACCTCGGCATCGGCATGCTGGGCATGATCGCCGCCAAGAGCCTCGACCAGCCGTTTATCCAGGCGATGGAACAGGGGATGCTGCCGGCGCTGGGCATGAGCCACACCTACGTTCAGGTGCCGGCGGCGCAGATGGCTAACTATGCGCAGGGTTACAGCAAGGACGATAAGCCGGTGCGGGTCAACCCCGGCCCGCTGGATGCCGAGTCTTACGGCATCAAGTCCAACGCTCGCGATCTGATTCGCTATCTGGACGCCAACCTGCAGCAGGTGAAGGTGGCGCAGCCGTGGCGCGACGCGCTGGCCGCGACGCACGTCGGGTATTACAAGGCGGGCGCGTTCACGCAGGATCTGATGTGGGAGAACTACCCGTATCCGGTGAAACTGTCGCGTTTGATTGAAGGCAACAACGCCGGGATGATCATGAACGGCACGCCGGCCACCGCCATCACGCCGCCGCAGCCGGAATTGCGCGCCGGCTGGTATAACAAAACCGGCTCCACCGGCGGCTTCTCCACCTACGCGGTATTTATCCCGGCGAAAAATATCGCCGTGGTGATGCTGGCCAACAAGTGGTTCCCGAACGACGATCGCGTCGAGGCGGCTTACCACATCGTCCAGGCGCTGGAGAAGCGCTGA", "partial": "0", "query_start": 1936, "query_end": 2721, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 42.21}, "gnl|BL_ORD_ID|184|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "SRT-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "725", "model_id": "199", "ARO_accession": "3002493", "ARO_name": "SRT-1", "ARO_category": {"36234": {"category_aro_accession": "3000095", "category_aro_cvterm_id": "36234", "category_aro_name": "SRT beta-lactamase", "category_aro_description": "SRT beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.4167e-67, "max_identities": 104, "bit_score": 213.001, "cvterm_id": "36783", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNA", "match": "+D+ I+PLM +  +PGMA+AVSV GK   + YG A  Q  +P+TE TLFE+GS+SKTFT  L   +  + +++ NDPA++Y PEL    + G++LL+LAT+T+ GLPL VPD V + A L+ +Y+ WQP    G  R+Y+N  I + G + A +   P+ Q +   +L  LG+SHT++ VP +  + YA GY K+ KPVRV+PG LDA+SYG+KS ++D++R+ + N++  +  +A", "sequence_from_db": "IDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEQTLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTS-GLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIVMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAKSYGIKSNARDLIRYLDANLQQVKVAHA", "sequence_from_broadstreet": "MTKMNRLAAALIAALILPTAQAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEQTLFEVGSLSKTFTATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSGLPLFVPDDVTNDAQLMAYYRAWQPKHPAGSYRVYSNLGIVMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAKSYGIKSNARDLIRYLDANLQQVKVAHAWRDALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLANKWFPNDDRVEAAYHIVQALEKR", "dna_sequence_from_broadstreet": "ATGACGAAAATGAACCGCCTGGCGGCCGCGCTGATCGCCGCACTGATCTTGCCGACCGCGCAGGCCGCGCAGCAGCAGGATATCGACGCCGTTATTCAGCCGCTGATGAAAAAATATGGCGTACCGGGCATGGCGATCGCCGTGTCGGTCGACGGCAAACAGCAGATTTACCCGTATGGCGTCGCCTCGAAGCAGACCGGCAAACCGATCACCGAGCAGACGCTGTTCGAAGTGGGCTCGCTGAGCAAAACCTTTACCGCGACGCTGGCGGTCTATGCGCAGCAGCAGGGCAAGCTGTCGTTCAACGATCCGGCCAGCCGCTATCTGCCCGAGCTGCGCGGCAGCGCCTTCGACGGCGTCAGCCTGCTGAATCTGGCGACGCATACCTCCGGCCTGCCGCTGTTCGTGCCGGACGACGTCACCAACGACGCCCAGCTGATGGCCTACTACCGGGCCTGGCAGCCGAAACACCCGGCGGGCAGCTACCGCGTCTATTCCAACCTCGGCATCGTCATGCTGGGCATGATCGCCGCCAAGAGCCTCGACCAGCCGTTTATCCAGGCGATGGAACAGGGGATGCTGCCGGCGCTGGGCATGAGCCACACCTACGTTCAGGTGCCGGCGGCGCAGATGGCTAACTATGCGCAGGGTTACAGCAAGGACGATAAGCCGGTGCGGGTCAATCCCGGCCCGCTGGACGCCAAATCTTACGGCATCAAGTCCAACGCTCGCGATCTGATTCGCTATCTGGACGCCAACCTGCAGCAGGTGAAGGTGGCGCACGCGTGGCGCGACGCGCTGGCCGCGACGCACGTCGGGTATTACAAGGCGGGCGCGTTCACGCAGGATCTGATGTGGGAGAACTACCCGTATCCGGTGAAACTGTCGCGTTTGATTGAAGGCAACAACGCCGGGATGATCATGAACGGCACGCCGGCCACCGCCATCACGCCACCGCAGCCGGAATTGCGCGCCGGCTGGTATAACAAAACCGGCTCCACCGGCGGCTTCTCCACCTACGCGGTATTTATCCCGGCGAAAAATATCGCCGTGGTGATGCTGGCCAACAAGTGGTTCCCGAACGACGATCGCGTCGAGGCGGCTTACCACATCGTCCAGGCGCTGGAGAAGCGCTGA", "partial": "0", "query_start": 1936, "query_end": 2640, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 44.07}, "gnl|BL_ORD_ID|2513|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-16", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2346", "ARO_accession": "3003860", "ARO_name": "ADC-16", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.08384e-66, "max_identities": 107, "bit_score": 210.305, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSA----ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS+  ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  NT+FELGSVSK FT   G  +  K  ++ ND   KY  EL       + LL LATYT+G L LQ PD VK+   +L F+++W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSSSIYAGNTPKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKTKGTISFNDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSSSIYAGNTPKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKTKGTISFNDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQKYPANIQRAINETHQGFYQVGTMYQALGWEEFSYPALLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCGCCTCTTTTTATTTTTAGTAGCTCAATTTATGCGGGTAATACACCAAAAGAGCAAGAGATCAAAAAACTGGTTGATCAAAATTTTAAGCCTTTATTAGAAAAATATGATGTGCCCGGTATGGCTGTGGGCGTTATTCAAAATAACAAAAAGTATGAAATGTATTATGGTCTACAATCCGTTCAAGATAAAAAAGCCGTTAATAGCAATACCATTTTTGAGCTAGGCTCGGTCAGTAAATTATTTACCGCTACAGCAGGCGGATATGCCAAAACAAAAGGAACAATCTCTTTTAATGACACGCCTGGAAAATATTGGAAAGAACTAAAAAATACACCGATTGATCAAGTGAATTTACTTCAACTTGCGACATATACCAGTGGCAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACGTTTTTCAAAGAATGGAAACCTAAAAACCCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTTGACCAAGTCTTGGAAAAAACCATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTGCCTAAAACTCAAATGCAAAACTATGCATTTGGCTATAACCAAGAAAATCAGCCGATTCGCGTCAATCCTGGTCCACTCGATGCACCAGCATACGGCGTTAAATCTACCCTACCGGATATGCTGAGTTTTATTAATGCAAACCTAAATCCACAAAAATATCCAGCAAATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACCATGTATCAAGCACTAGGTTGGGAAGAGTTCTCTTATCCAGCACTTTTACAAACTTTATTAGACAGTAATTCAGAACAAATCGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAACCTTCCGTTAAGATGTTCCACAAAACTGGATCGACTAACGGTTTTGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACTAATAAACGTATTCCCAATGAAGAACGCATTAAAGCAGCTTATGCTGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.53}, "gnl|BL_ORD_ID|2200|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2340", "ARO_accession": "3003853", "ARO_name": "ADC-7", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.1125e-66, "max_identities": 109, "bit_score": 209.534, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  NT+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCTGTAAATAGCAATACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAGCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.98}, "gnl|BL_ORD_ID|2199|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2340", "ARO_accession": "3003853", "ARO_name": "ADC-7", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.1125e-66, "max_identities": 109, "bit_score": 209.534, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  NT+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCTGTAAATAGCAATACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAGCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.98}, "gnl|BL_ORD_ID|2432|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-20", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2350", "ARO_accession": "3003864", "ARO_name": "ADC-20", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.35251e-65, "max_identities": 108, "bit_score": 208.764, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D + KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKTVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKTVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGTGTTATTCAGAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAACCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGTCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAATTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGCCTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAAGCAGCGTATGCCGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.6}, "gnl|BL_ORD_ID|2130|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-30", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3315", "ARO_accession": "3004617", "ARO_name": "ADC-30", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.28586e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2521|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-75", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2364", "ARO_accession": "3003881", "ARO_name": "ADC-75", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.36049e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2175|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-67", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3332", "ARO_accession": "3004633", "ARO_name": "ADC-67", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.3859e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2524|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-78", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2367", "ARO_accession": "3003884", "ARO_name": "ADC-78", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.57163e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2527|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-82", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2371", "ARO_accession": "3003888", "ARO_name": "ADC-82", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.59931e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "42628", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDALAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDALAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCTAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2459|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-25", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2354", "ARO_accession": "3003868", "ARO_name": "ADC-25", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.74228e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2141|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Acinetobacter baumannii AmpC beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "750", "model_id": "2300", "ARO_accession": "3003796", "ARO_name": "Acinetobacter baumannii ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35976": {"category_aro_accession": "0000059", "category_aro_cvterm_id": "35976", "category_aro_name": "cefepime", "category_aro_description": "Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.98756e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35531", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2133|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3310", "ARO_accession": "3004615", "ARO_name": "ADC-11", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.05223e-65, "max_identities": 106, "bit_score": 207.994, "cvterm_id": "35535", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2338|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-39", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2356", "ARO_accession": "3003871", "ARO_name": "ADC-39", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.15187e-65, "max_identities": 106, "bit_score": 207.608, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCACCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2136|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-59", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3317", "ARO_accession": "3004619", "ARO_name": "ADC-59", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.90457e-65, "max_identities": 106, "bit_score": 207.608, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAATAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2202|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2338", "ARO_accession": "3003851", "ARO_name": "ADC-5", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.32141e-65, "max_identities": 106, "bit_score": 206.838, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLTPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLTPQKYPTDIQRAINETHQGFYQVGTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCATTATTAGAAAAATATGATGTACCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGATCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGCAACCTCGCTTTACAATTTCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTTGATGCCCCAGCATACGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTACCCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTGGTCTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2525|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-79", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2368", "ARO_accession": "3003885", "ARO_name": "ADC-79", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.66482e-65, "max_identities": 108, "bit_score": 206.838, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAADN------VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   +  ADN      +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIY--ADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MQFKKISCLLLSPLFIFSTSIYADNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCAATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGACAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCATTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTGTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.6}, "gnl|BL_ORD_ID|2431|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-19", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2349", "ARO_accession": "3003863", "ARO_name": "ADC-19", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.03437e-64, "max_identities": 104, "bit_score": 206.453, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGF----SAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  F+   +    S    +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  +L       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFNTSIYAGNTSKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKKLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFNTSIYAGNTSKEQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKKLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPALLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTATCTCCTCTTTTTATTTTTAATACATCAATTTATGCGGGCAATACATCAAAAGAACAAGAAATTAAAAAACTGGTAGATCAGAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCTGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTTAGTAAATTATTTACCGCAACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAAAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTGGCATTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCACTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCTTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2519|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-61", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2362", "ARO_accession": "3003879", "ARO_name": "ADC-61", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.13897e-64, "max_identities": 106, "bit_score": 206.453, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P +Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTCTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2131|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-58", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3316", "ARO_accession": "3004618", "ARO_name": "ADC-58", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.15123e-64, "max_identities": 106, "bit_score": 206.453, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N  P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANFNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANFNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGATCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACTTCAACCCACAGAAATATCCGGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCACCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2337|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2355", "ARO_accession": "3003870", "ARO_name": "ADC-31", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.21452e-64, "max_identities": 106, "bit_score": 206.453, "cvterm_id": "35649", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P +Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPLDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTAGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAGCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.15}, "gnl|BL_ORD_ID|2518|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-56", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2361", "ARO_accession": "3003878", "ARO_name": "ADC-56", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.30901e-64, "max_identities": 105, "bit_score": 206.068, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ + Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYQQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYQQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCAACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2203|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-12", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2342", "ARO_accession": "3003856", "ARO_name": "ADC-12", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.3231e-64, "max_identities": 105, "bit_score": 206.068, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F+++W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDTQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGSYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAATCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGAATGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCCGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATACTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGATCTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2161|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-60", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3318", "ARO_accession": "3004620", "ARO_name": "ADC-60", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.50443e-64, "max_identities": 105, "bit_score": 206.068, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+R +PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTTTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGCTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2515|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-42", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2358", "ARO_accession": "3003873", "ARO_name": "ADC-42", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.84369e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D + KY  EL       + LL LATYT+G L LQ PD V++   +L F+++W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKSVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTSGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKEWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQKYPKDTQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGSYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAATCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGTCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGAATGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCCGGTCCGCTAGATGCTCCAGCATACGGTGTTAAATCGACCTTACCTGATATGCTGAGTTTCATTAATGCCAATATAAATCCACAAAAATATCCGAAAGATACTCAACGTGCAATTAATGAAACACATCAAGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGATCTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2167|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2335", "ARO_accession": "3003848", "ARO_name": "ADC-2", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.25941e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "36930", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCTCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTAATGCCAACCTTAACCCACAAAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2520|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-74", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2363", "ARO_accession": "3003880", "ARO_name": "ADC-74", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.28372e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+R +PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRANPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGCTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCACCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2523|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-77", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2366", "ARO_accession": "3003883", "ARO_name": "ADC-77", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.33313e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCTCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTAATGCCAACCTTAACCCACAAAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2176|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-73", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "680", "model_id": "3333", "ARO_accession": "3004634", "ARO_name": "ADC-73", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.3836e-64, "max_identities": 105, "bit_score": 205.682, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +Y VKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYSVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYSVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATAGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2514|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-41", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2357", "ARO_accession": "3003872", "ARO_name": "ADC-41", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.08158e-64, "max_identities": 105, "bit_score": 205.297, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKNQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKNQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPADIQRAINETHQGFYQVGIMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGAACCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATACGGCGTCAAATCGACACTACCCGATATGCTTAAGTTTATTAATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCATCATGTATCAAGCATTAGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCCGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2195|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2334", "ARO_accession": "3003847", "ARO_name": "ADC-1", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.38657e-64, "max_identities": 105, "bit_score": 204.912, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG L A +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLGAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLGAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNRFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGGTGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACCGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2511|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2345", "ARO_accession": "3003859", "ARO_name": "ADC-15", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.48145e-64, "max_identities": 104, "bit_score": 204.912, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  F+   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + L  LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++QLL   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTTGKYWKELKNTPIDQVNLFQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQLLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTTGKYWKELKNTPIDQVNLFQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQLLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKIFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAATACCTCAATTTATGCAGGGAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTACGGCCTACAATCCGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTCGGTTCAGTTAGTAAATTATTTACCGCTACAGCAGGTGGATATGCCAAAACAAAAGGAACAATTTCTTTTAAAGACACAACCGGAAAATATTGGAAAGAATTAAAAAACACACCAATTGACCAAGTTAACTTATTTCAACTTGCTACTTATACGAGTGGCAACCTTGGCTTACAGTTTCCAGATGAAGTCCAAACAGATCAGCAAGTTTTAACTTTTTTCAAAGACTGGAAGCCTAAAAACTCAATCGGTGAATATCGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCATTGTCTATGAATAAACCTTTCGACCAACTCTTAGAAAAAACAATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTACCGAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGTTAGATGCACCTGCGTACGGCGTCAAATCGACACTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATATTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCGGTGTTAAATGCAATAAAAAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2207|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-62", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3331", "ARO_accession": "3004632", "ARO_name": "ADC-62", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.43322e-64, "max_identities": 104, "bit_score": 204.527, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD VK+   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+R++ G LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRINSGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVKTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRINSGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTTGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAGTATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAATTTCCAGATGAAGTAAAAACAGATCAGCAAGTTTTAACATTTTTTAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATCGACAATATTCAAACCCAAGCATTGGTTTATTTGGAAAAGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAATTAACTCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGGGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTACCGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGTTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2197|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2337", "ARO_accession": "3003850", "ARO_name": "ADC-4", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.98239e-64, "max_identities": 105, "bit_score": 204.527, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNRFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACTGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCCTTCCGGATATGTTGAGTTTTATTTATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAAAGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACCGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2196|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2336", "ARO_accession": "3003849", "ARO_name": "ADC-3", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.65131e-64, "max_identities": 105, "bit_score": 204.142, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFFFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFFFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIYANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLSAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTTTTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACTGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCCTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCTGGCCCACTCGATGCCCCAGCATACGGCGTCAAATCCACCTTACCGGATATGTTGAGTTTTATTTATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAAAGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAGTGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2198|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2339", "ARO_accession": "3003852", "ARO_name": "ADC-6", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.15935e-63, "max_identities": 104, "bit_score": 202.986, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L  ++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTLFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTLFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPAMLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTGTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCAACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCGGCAGATATTCAACGTGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAATGTTACAAACTTTACTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACGTATGTGGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCGTATGCAGTTTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2510|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-14", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2344", "ARO_accession": "3003858", "ARO_name": "ADC-14", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.18257e-63, "max_identities": 104, "bit_score": 202.986, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   L L H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPADIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERFKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTTGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATTTATTATGGTCTACAATCCGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAACAAAAGGAACAATCTCTTTTAAAGACACACCCGGAAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAGCTTGCTACCTATACAAGTGGGAACCTTGCTTTGCAATTTCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGATTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTAGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACACTACCAGACATGCTTAAGTTTATTAATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCACCATGTATCAAGCATTAGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACCGCTATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACCAATGGTTTCGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCTTTAAGGCAGCGTATGCAGTGTTAAACGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2509|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2343", "ARO_accession": "3003857", "ARO_name": "ADC-13", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.18257e-63, "max_identities": 104, "bit_score": 202.986, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   L L H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPADIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTTGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATTTATTATGGTCTACAATCCGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAACAAAAGGAACAATCTCTTTTAAAGACACACCCGGAAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTTGCTACCTATACAAGTGGGAACCTTGCTTTGCAATTTCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGATTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTAGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACACTACCAGACATGCTTAAGTTTATTAATGCCAACCTAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCACCATGTATCAAGCATTAGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCTATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACCAATGGTTTCGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTGTTAAACGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2692|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-68", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "3013", "ARO_accession": "3004493", "ARO_name": "ADC-68", "ARO_category": {"42444": {"category_aro_accession": "3004545", "category_aro_cvterm_id": "42444", "category_aro_name": "ADC beta-lactamase with carbapenemase activity", "category_aro_description": "ADC beta-lactamase enzymes with demonstrable carbapenemase activity, an exception amongst these enzymes.", "category_aro_class_name": "AMR Gene Family"}, "35939": {"category_aro_accession": "0000020", "category_aro_cvterm_id": "35939", "category_aro_name": "carbapenem", "category_aro_description": "Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.53146e-63, "max_identities": 104, "bit_score": 202.601, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  F+   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   GA +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ V ++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGAYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVAKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFNTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGAYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKIIFPALGLKHSYVNVAKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAATACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGCTTATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCTGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGATCAAGTCTTAGAAAAAATAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTAGCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTAAATCCACAAAAATATCCGGCTGATATTCAACGTGCAATTAATGAAACACATCAGGGTCGCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAAGAGCCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2507|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Laribacter hongkongensis ampC beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2845", "ARO_accession": "3004292", "ARO_name": "Laribacter hongkongensis ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.02288e-63, "max_identities": 109, "bit_score": 202.216, "cvterm_id": "41458", "query": "VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLE", "match": "+D+ ++ +M    IPGMA+A+   GK  Y NYG A  +  QPV E TLFE+GS+SK FT ++   +  +  + L+ PA++Y   L    +  ITL  L TY+AGGLPLQ PD V + AD+L +YQ WQP    G  RLY+N SIGL G   + A G  +  LL   +L PLG++ T++ VP  A+S+YA GY    K VRVSPG LD E+YGVKS + DM  +   +M+P+R  + GAL + L+", "sequence_from_db": "MDAMVQTVMQAHQIPGMAIAIIQPGKTTYHNYGVASRETGQPVRETTLFEIGSLSKPFTALVAQRAETEGRIDLSAPASRYVAALRGSAFDRITLRQLGTYSAGGLPLQFPDNVTTPADVLAYYQHWQPVHPAGTTRLYSNPSIGLMGLAASQATGESFAGLLGTTVLHPLGMNSTYLQVPPEARSRYAMGYTAAGKAVRVSPGPLDEETYGVKSTTADMAGFLLAHMDPAR--SKGALQSALQ", "sequence_from_broadstreet": "MKKRITPFSRFASKGLFACSAGMLLVTVAHAANTAAAPAGMDAMVQTVMQAHQIPGMAIAIIQPGKTTYHNYGVASRETGQPVRETTLFEIGSLSKPFTALVAQRAETEGRIDLSAPASRYVAALRGSAFDRITLRQLGTYSAGGLPLQFPDNVTTPADVLAYYQHWQPVHPAGTTRLYSNPSIGLMGLAASQATGESFAGLLGTTVLHPLGMNSTYLQVPPEARSRYAMGYTAAGKAVRVSPGPLDEETYGVKSTTADMAGFLLAHMDPARSKGALQSALQQTRVPVYCAGQTRQGLGWESYQDWKNLDVLLAGNSNQMVFEPQPVKACPAGTMNDPDVWVNKTGSTAGFGAYAVFLPARQTGIVILANRNFPIADRIRLAHGILTALH", "dna_sequence_from_broadstreet": "ATGAAAAAACGGATTACCCCATTTTCCCGCTTTGCATCAAAAGGCCTTTTCGCCTGTAGCGCAGGCATGTTGCTGGTGACGGTGGCACATGCTGCCAATACGGCAGCAGCACCAGCCGGCATGGATGCCATGGTACAAACCGTGATGCAGGCACACCAGATTCCGGGCATGGCCATTGCCATCATCCAGCCAGGAAAGACCACTTATCACAATTATGGTGTCGCCTCCCGCGAAACCGGCCAGCCGGTCCGGGAAACCACCCTGTTTGAAATCGGGTCCCTTTCCAAACCGTTTACTGCACTGGTCGCCCAGCGGGCTGAAACCGAAGGCCGGATTGACCTGTCTGCACCGGCCAGCCGCTACGTTGCCGCCCTGCGAGGCAGTGCATTCGACCGGATCACCCTCAGGCAGCTCGGTACTTATAGCGCAGGCGGATTACCGCTCCAGTTTCCTGACAATGTCACCACCCCGGCAGACGTGCTGGCTTATTACCAGCATTGGCAACCTGTCCATCCGGCAGGTACCACCCGGCTGTATTCCAATCCGAGCATTGGCCTGATGGGGCTGGCTGCCAGTCAGGCAACCGGAGAGTCCTTTGCCGGCCTGCTCGGGACAACGGTGCTGCACCCCCTCGGCATGAACTCGACCTATCTGCAAGTGCCCCCGGAGGCCCGTTCACGTTATGCCATGGGATATACCGCCGCCGGAAAAGCGGTCAGGGTCAGCCCCGGTCCGCTGGATGAGGAAACCTACGGCGTCAAGTCCACAACCGCAGACATGGCCGGATTTTTATTGGCGCATATGGACCCTGCGCGCAGCAAAGGTGCATTGCAGTCGGCATTACAGCAAACACGTGTACCGGTTTATTGCGCCGGACAGACCCGGCAAGGACTGGGCTGGGAAAGTTATCAAGACTGGAAAAACCTAGACGTGCTGCTGGCGGGAAATTCAAATCAAATGGTGTTTGAGCCGCAGCCGGTAAAAGCCTGTCCTGCCGGCACCATGAATGATCCTGATGTGTGGGTCAACAAGACCGGTTCTACTGCGGGATTCGGCGCTTATGCCGTATTCCTGCCTGCCCGACAGACCGGCATTGTCATCCTGGCCAACCGTAATTTCCCGATTGCAGACCGTATCCGGCTCGCTCACGGGATTTTGACCGCATTGCACTGA", "partial": "0", "query_start": 1936, "query_end": 2664, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 44.67}, "gnl|BL_ORD_ID|2522|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-76", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2365", "ARO_accession": "3003882", "ARO_name": "ADC-76", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.18942e-63, "max_identities": 104, "bit_score": 202.216, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY   L       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKVLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGESRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKVLKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGESRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACCCCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCGTTATTAGAAAAATATGATGTGCCGGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGTGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATCCAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATACGGTGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGACAGATATTCAACGGGCAATTAATGAAACACATCAAGGTCGCTATCAAGTAAATACCATGTATCAAGCGCTTGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTGGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGTATTAAGGCAGCGTATGCAGTTTTAAATGCAATAAAAAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2435|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-23", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2353", "ARO_accession": "3003867", "ARO_name": "ADC-23", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.49566e-63, "max_identities": 105, "bit_score": 201.83, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSA----ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        V  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  + AK +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+     G+ R Y+N SIGLFG + A +   P++Q+L   I  PL L ++++ VP++    YAYGY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKIVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKIVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPASLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCGCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGAACAAGAAGTTAAAAAACTGGTAGATCAAAATTTTAAGCCTTTATTAGATAAATATGATGTGCCTGGTATGGCCGTGGGGGTCATTCAAAATAATAAAAAATATGAAATATATTATGGCCTACAATCCGTTCAGGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAACTAGGTTCGGTCAGTAAATTATTTACCGCTACAGCTGGTGGATATGCAAAAGCAAAAGGAAAAATCTCTTTTGATGACACACCCGGAAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAATCTTCTTCAACTTGCGACGTATACAAGTGGCAATCTCGCCTTACAATTTCCAGATGAAGTTCAAACAGACCAACAAGTTTTAACTTTTTTCAAAGATTGGAAAACTAAAAACGCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAATTGTGGCTTTGTCTATGAATAAACCTTTTGACCAAGTCTTAGAAAAAACAATTTTTCCACCTCTCCATTTAAAAAATAGCTATGTAAATGTACCTAAAACTCAAATGCAAAATTATGCATATGGCTATAACCAAGAAAATCAGCCGATCCGAGTTAACCCTGGTCCGCTAGATGCCCCTGCGTACGGCGTTAAATCGACACTACCAGATATGCTGACTTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGTACGATGTATCAAGCATTGGGTTGGGAAGAATTTTCTTATCCAGCGTCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGAACTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2516|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-43", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2359", "ARO_accession": "3003874", "ARO_name": "ADC-43", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.54435e-63, "max_identities": 104, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPLK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANLNPLKYPKDIQRAINETHKGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCCCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTCGGTTCAGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAATTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAATTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCTGCATACGGCGTTAAATCGACACTACCAGACATGCTGAGTTTTATTAATGCCAACCTCAACCCACTGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATAAAGGTTTCTATCAAGTCGGCACCATGTATCAAGCCTTGGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGAACTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTGAATGCTATAAAAAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2430|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-18", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2348", "ARO_accession": "3003862", "ARO_name": "ADC-18", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.48574e-63, "max_identities": 105, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSA----ADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        V  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  + AK +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+     G+ R Y+N SIGLFG + A +   P++Q+L   I  PL L ++++ VP++    YAYGY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKEQEVKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEIYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKAKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKTKNAIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPPLHLKNSYVNVPKTQMQNYAYGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLTFINANLNPQKYPKDIQRAISETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGSYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCGCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGAACAAGAAGTTAAAAAACTGGTAGATCAAAATTTTAAGCCTTTATTAGATAAATATGATGTGCCTGGTATGGCCGTGGGGGTCATTCAAAATAATAAAAAATATGAAATATATTATGGCCTACAATCCGTTCAGGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAACTAGGTTCGGTCAGTAAATTATTTACCGCTACAGCTGGTGGATATGCAAAAGCAAAAGGAAAAATCTCTTTTGATGACACACCCGGAAAATATTGGAAAGAACTAAAAAATACACCGATTGACCAAGTTAATCTTCTTCAACTTGCGACGTATACAAGTGGCAATCTCGCCTTACAATTTCCAGATGAAGTTCAAACAGACCAACAAGTTTTAACTTTTTTCAAAGATTGGAAAACTAAAAACGCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCTTATTTGGAAAAGTTGTGGCTTTGTCTATGAATAAACCTTTTGACCAAGTCTTAGAAAAAACAATTTTTCCACCTCTCCATTTAAAAAATAGCTATGTAAATGTACCCAAAACTCAAATGCAAAATTATGCATATGGCTATAACCAAGAAAATCAGCCGATCCGAGTTAACCCTGGCCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACACTACCAGATATGCTGACTTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAGTGAAACACATCAAGGTTTCTATCAAGTCGGTACGATGTATCAAGCATTGGGTTGGGAAGAATTTTCTTATCCAGCACCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGATCTTATGTGGTGTTTATTCCAAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCAGTATTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.77}, "gnl|BL_ORD_ID|2512|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-17", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2347", "ARO_accession": "3003861", "ARO_name": "ADC-17", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.14506e-63, "max_identities": 103, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+   +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDRQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNRENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDRQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNRENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCTCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTGTTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATTTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACGCCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCGACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTGGCATTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTTGGCCTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCGAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACACACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCCGTGTTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.02}, "gnl|BL_ORD_ID|2433|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-21", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2351", "ARO_accession": "3003865", "ARO_name": "ADC-21", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.24334e-63, "max_identities": 104, "bit_score": 201.445, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+     G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKLKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKLKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFINANINPQKYPADIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSIKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAATTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGTGTTATTCAGAATAATAAAAAGTATGAAATGTATTATGGTCTACAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGTACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACTTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAAGTTGTTGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTGGGATTAAAACATAGTTATGTAAATGTGCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAATCAAGAAAATCAGCCAATTCGTGTTAACCCCGGTCCGCTAGATGCTCCAGCATACGGCGTTAAATCGACCCTACCTGATATGCTGAGTTTCATTAATGCCAATATAAATCCACAAAAATATCCAGCAGATATTCAACGTGCAATTAATGAAACACATCAAGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCCAAAGAACCTTCAATTAAGATGTTCCACAAAACTGGTTCGACTAACGGTTTTGGAACATATGTCGTGTTCATTCCTAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCGAATGAAGAACGCATTAAAGCAGCTTATGCTGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.39}, "gnl|BL_ORD_ID|2526|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-81", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2370", "ARO_accession": "3003887", "ARO_name": "ADC-81", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.76089e-63, "max_identities": 106, "bit_score": 201.445, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLD-----AESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ WQP    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LD     A +YGVKS   DML +   N+ P +", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGAPAYGVKSTLPDMLSFIHANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNRSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWQPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGAPAYGVKSTLPDMLSFIHANLNPQKYPADIQRAINETHQGFYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLDAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAAATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATCGCAGTACCATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGCAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTGGCTTTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAGATGCAAAACTATGCATTTGGTTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCTGCATATGGCGCCCCTGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGAAATATCCGGCTGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGTAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACCAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGCTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGGATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.41}, "gnl|BL_ORD_ID|2434|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-22", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2352", "ARO_accession": "3003866", "ARO_name": "ADC-22", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.44808e-62, "max_identities": 103, "bit_score": 201.06, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V+ +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+   +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTPKDREIKKLVDQNFKPLLDKYDVPGMAVGVIQNNKKYETYYGLQSVQDKKAVSSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPDLGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNTQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSVKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCTCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCGAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATGATGTGCCGGGTATGGCCGTGGGCGTTATTCAGAATAATAAAAAATATGAAACGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAGTAGCAGCACCATTTTTGAACTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATTTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAACTAAAAAACACACCGATTGACCAAGTTAACTTACTTCAACTCGCAACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACTCAATCGGTGAATATAGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTGGCATTGTCTATGAATAAACCTTTCGACCAAGTCTTAGAAAAAACAATTTTTCCAGATCTTGGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGCTAGATGCTCCAGCATATGGGGTTAAATCGACGCTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACACACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTATCAAGTCGGCACCATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAACAAATTGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAGTTAAGATGTTCCACAAAACTGGTTCAACCAATGGTTTCGGAACTTATGTCGTGTTCATTCCTAAAGAAAATATTGGTTTAGTCATGTTAACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCGTATGCCGTGTTAAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.02}, "gnl|BL_ORD_ID|2517|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-44", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2360", "ARO_accession": "3003876", "ARO_name": "ADC-44", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.72035e-62, "max_identities": 103, "bit_score": 200.29, "cvterm_id": "36787", "query": "KSLSATLISALLAFSAPGF----SAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+  L  FS   +    S    +  +VD   KPL+ + ++PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K  ++  D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   L L H+++ VP++    YA+GY +  +P+RV+PG LDA +YGVKS   DML++   N+ P +", "sequence_from_db": "KKISCLLLPPLFIFSTSIYAGNTSKEQEIKKLVDQNFKPLLDKYNVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQK", "sequence_from_broadstreet": "MRFKKISCLLLPPLFIFSTSIYAGNTSKEQEIKKLVDQNFKPLLDKYNVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKTKGTISFKDTPGKYWKELKNTPIDQVNLLQLATYTSGNLGLQFPDEVQTDQQVLTFFKDWKPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPGLSLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLKFINANLNPQKYPKDIQRAINETHQGFYQVGTMYQALGWEEFSYPAPLQTLLDSNSEQIVMKPNKVTAISKEPSIKMFHKTGSTNGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGCTTACTTTTACCCCCTCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACATCAAAAGAACAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCTTTATTAGATAAATATAATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACCATTTTTGAGCTAGGTTCAGTTAGTAAATTATTTACCGCGACAGCAGGTGGATATGCCAAAACAAAAGGAACAATCTCTTTTAAAGACACACCCGGAAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTTGCTACCTATACAAGTGGCAACCTTGGCTTACAGTTTCCAGATGAAGTACAAACAGACCAACAAGTTTTAACTTTTTTCAAAGACTGGAAGCCTAAAAACTCAATCGGTGAATATCGACAATATTCAAATCCAAGCATTGGTTTATTTGGAAAAGTTGTTGCATTGTCTATGAATAAACCTTTCGATCAAGTCTTAGAAAAAACAATTTTTCCGGGCCTTAGCTTAAAACATAGCTATGTAAATGTTCCTAAAACTCAGATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCAATTCGTGTTAACCCTGGTCCGTTAGATGCACCTGCGTACGGCGTCAAATCGACACTACCCGATATGCTTAAGTTTATTAATGCCAACCTCAACCCACAGAAATATCCGAAAGATATTCAACGTGCAATTAATGAAACACATCAGGGTTTCTACCAAGTCGGCACGATGTATCAGGCACTTGGTTGGGAAGAATTTTCTTATCCAGCGCCTTTACAAACTTTATTAGACAGTAATTCAGAGCAAATCGTGATGAAGCCTAATAAAGTGACTGCCATTTCAAAAGAACCTTCAATTAAGATGTTCCACAAAACTGGCTCAACAAATGGCTTTGGAACTTATGTGGTGTTTATTCCAAAAGAAAATATTGGCTTAGTCATGTTGACCAATAAACGTATTCCAAATGAAGAACGCATTAAGGCAGCATATGCGGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.02}, "gnl|BL_ORD_ID|1806|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "LRA-13", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1912", "ARO_accession": "3002484", "ARO_name": "LRA-13", "ARO_category": {"41395": {"category_aro_accession": "3004231", "category_aro_cvterm_id": "41395", "category_aro_name": "class C LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class C beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "41405": {"category_aro_accession": "3004241", "category_aro_cvterm_id": "41405", "category_aro_name": "class D LRA beta-lactamase", "category_aro_description": "Beta-lactamases that are part of the LRA gene family and are classified as Class D beta-lactamases.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.09654e-61, "max_identities": 97, "bit_score": 204.142, "cvterm_id": "39085", "query": "PGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKN-KKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "PG    D    +VD  ++PLM + DIPGMAVAV+  GK Y+FNYG A  +  Q VT +TLFE+GS+SKT    L + +    ++AL D  +++ P+L    +  I+LL+L T+TAG  P+QVPD +++   L+ +Y+ W+P    G  R Y+N ++GL G +TA + GMP+ + +  R+   LG+ H++I VP +    YA GY     PVR++P  L  E+YGVK+ + D++R+ + NM", "sequence_from_db": "PGLMIKD----MVDRAVQPLMKKYDIPGMAVAVTDNGKNYFFNYGLASRETGQAVTSHTLFEIGSLSKTMAATLTSYAQVNGQLALTDTVSRHMPKLRGGGFDKISLLNLGTHTAGDFPMQVPDHIETYEQLMEYYKNWKPGVAAGGARTYSNLTVGLLGIITAQSMGMPFAEAMENRLFPQLGMHHSYINVPAAEMKNYAQGYNQANAPVRINPAVLATEAYGVKTDAADLIRFVDANM", "sequence_from_broadstreet": "MNFRHIVMAALCGLAWTPAIHATEVCIAIAEAGTGAVLVQRGDCQRQVTPASTFKIAISLMGYDSGFLKDAHAPKLPFRPGYVDWRPSWREPTDPAKWMSDSVVWYSQQVTKSLGMQRFADYTRNFKYGNADVSGDAENDGLSMSWISSSLRISPLEQLAFLDKIVNRRLGVSAHAYDMTAQLTKFDQPPAGWRINGKTGAASGYGWYVGWASKGSRTFVFAHLMQRDATQPQDVSAGVLARDEFLKELPGLMIKDMVDRAVQPLMKKYDIPGMAVAVTDNGKNYFFNYGLASRETGQAVTSHTLFEIGSLSKTMAATLTSYAQVNGQLALTDTVSRHMPKLRGGGFDKISLLNLGTHTAGDFPMQVPDHIETYEQLMEYYKNWKPGVAAGGARTYSNLTVGLLGIITAQSMGMPFAEAMENRLFPQLGMHHSYINVPAAEMKNYAQGYNQANAPVRINPAVLATEAYGVKTDAADLIRFVDANMGLVKLDEKLQRAVTGTHTAYFKTGELTQDLIWEQYPAASKLDRMLAGVSEKMVFESNPATRLAPPMPPQADVLINKTGSTGGFGAYALFNPGKKTGIVMLANKSYPGAERVTAAWHILDQLDQR", "dna_sequence_from_broadstreet": "ATGAATTTTCGCCACATAGTCATGGCGGCGCTGTGCGGTCTCGCCTGGACGCCAGCCATCCACGCCACCGAAGTGTGTATCGCCATCGCCGAGGCCGGCACCGGCGCTGTGCTGGTCCAGCGCGGCGATTGCCAGCGCCAGGTGACGCCGGCGTCGACCTTCAAGATCGCCATCAGCCTGATGGGCTACGACTCGGGTTTTCTGAAGGACGCGCACGCGCCGAAACTGCCGTTCCGTCCAGGCTATGTCGATTGGCGGCCCAGCTGGCGCGAACCGACGGATCCGGCCAAGTGGATGAGCGATTCGGTCGTATGGTATTCGCAGCAGGTGACAAAATCCCTGGGCATGCAGCGTTTCGCCGACTACACGCGGAACTTCAAGTATGGCAATGCCGACGTTTCGGGGGACGCGGAAAATGACGGCCTGAGCATGTCGTGGATAAGTTCCTCGCTGCGGATCTCGCCGCTGGAACAACTCGCGTTCCTGGACAAGATCGTCAACCGTCGGCTGGGCGTGAGCGCCCATGCCTACGACATGACCGCGCAATTGACGAAATTCGATCAGCCTCCGGCGGGATGGCGCATCAACGGCAAGACCGGCGCCGCCTCCGGTTATGGCTGGTACGTGGGATGGGCGTCGAAAGGTTCGCGAACCTTCGTCTTTGCGCACCTGATGCAGAGGGACGCGACGCAGCCGCAAGACGTGTCGGCGGGCGTGCTGGCGCGTGACGAATTCCTCAAGGAACTCCCCGGCTTGATGATCAAGGATATGGTGGACCGCGCCGTCCAGCCGTTGATGAAGAAATACGATATCCCGGGGATGGCGGTGGCCGTCACCGACAACGGCAAGAACTACTTCTTCAACTACGGGCTGGCGTCGAGGGAAACCGGGCAAGCCGTTACCAGCCACACCCTGTTCGAGATCGGTTCGCTGAGCAAGACCATGGCGGCAACGCTGACTTCCTACGCGCAGGTCAACGGCCAGCTTGCGTTGACCGACACGGTCAGCCGGCATATGCCCAAGCTGCGCGGCGGCGGCTTCGACAAGATCAGCCTGCTCAATCTGGGCACCCACACGGCCGGCGATTTTCCGATGCAGGTTCCCGACCATATCGAGACCTACGAGCAGCTGATGGAGTACTACAAAAACTGGAAGCCCGGGGTTGCTGCGGGCGGCGCCAGGACCTACTCCAACCTGACCGTCGGCCTGCTGGGCATCATCACGGCGCAAAGCATGGGCATGCCGTTTGCGGAGGCGATGGAAAACAGGTTGTTCCCCCAGCTTGGCATGCATCACAGCTATATCAATGTGCCGGCGGCGGAGATGAAGAACTACGCGCAAGGCTACAACCAGGCCAACGCACCGGTCAGGATCAATCCGGCGGTGCTGGCAACCGAGGCATACGGGGTAAAGACCGATGCCGCCGACTTGATCCGGTTTGTCGACGCCAACATGGGGTTGGTCAAGCTGGACGAAAAACTGCAGCGCGCGGTCACCGGCACGCACACCGCCTACTTCAAGACGGGTGAGCTGACGCAGGATCTGATCTGGGAACAATATCCCGCCGCATCGAAACTCGATCGCATGCTGGCGGGCGTTTCCGAAAAAATGGTCTTTGAAAGCAATCCCGCGACCAGGCTGGCGCCGCCGATGCCGCCGCAAGCGGATGTGCTGATCAACAAGACCGGATCAACCGGCGGCTTTGGCGCCTATGCGCTGTTCAACCCGGGCAAGAAGACCGGCATCGTGATGCTGGCGAACAAGAGCTATCCTGGCGCAGAAAGGGTGACGGCGGCCTGGCACATACTGGATCAACTGGACCAGCGTTAG", "partial": "0", "query_start": 1900, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 40.42}, "gnl|BL_ORD_ID|2129|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ADC-10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3314", "ARO_accession": "3003855", "ARO_name": "ADC-10", "ARO_category": {"40543": {"category_aro_accession": "3003846", "category_aro_cvterm_id": "40543", "category_aro_name": "ADC beta-lactamase without carbapenemase activity", "category_aro_description": "ADC beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases with extended-spectrum resistance to cephalosporins but not to carbapenems. ADC beta-lactamases are found in Acinetobacter sp. and Oligella urethralis.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.22685e-61, "max_identities": 105, "bit_score": 198.749, "cvterm_id": "35507", "query": "KSLSATLISALLAFSAPGFSAA----DNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDA-----ESYGVKSASKDMLRWAEMNMEPSR", "match": "K +S  L+S L  FS   ++        +  +VD   KPL+ + D+PGMAV V    K Y   YG   +Q K+ V  +T+FELGSVSK FT   G  +  K +++ +D   KY  EL       + LL LATYT+G L LQ PD V++   +L F++ W+P    G+ R Y+N SIGLFG + A +   P++Q+L   I   LGL H+++ VP++    YA+GY +  +P+RV+PG LDA      +YGVKS   DML +   N+ P  ", "sequence_from_db": "KKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLERYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVPAYGVKSTLPDMLSFIHANLNPQE", "sequence_from_broadstreet": "MRFKKISCLLLSPLFIFSTSIYAGNTPKDQEIKKLVDQNFKPLLERYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVPAYGVKSTLPDMLSFIHANLNPQEYPADIQRAINETHQGFYQANTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTNGFGTYVVFIPKENIGLVTLTNKRIPNEERIKAAYAVLNAIKK", "dna_sequence_from_broadstreet": "ATGCGATTTAAAAAAATTTCTTGTCTACTTTTATCCCCGCTTTTTATTTTTAGTACCTCAATTTATGCGGGCAATACACCAAAAGACCAAGAAATTAAAAAACTGGTAGATCAAAACTTTAAACCGTTATTAGAAAGATATGATGTGCCAGGTATGGCTGTGGGTGTTATTCAAAATAATAAAAAGTATGAAATGTATTATGGTCTTCAATCTGTTCAAGATAAAAAAGCCGTAAATAGCAGTACTATTTTTGAGCTAGGTTCTGTCAGTAAATTATTTACCGCGACAGCAGGTGGATATGCAAAAAATAAAGGAAAAATCTCTTTTGACGATACGCCTGGTAAATATTGGAAAGAGCTAAAAAATACACCGATTGACCAAGTTAACTTACTTCAACTCGCGACGTATACAAGTGGTAACCTTGCCTTGCAGTTCCCAGATGAAGTACAAACAGATCAACAAGTTTTAACTTTTTTCAAAGACTGGAAACCTAAAAACCCAATCGGTGAATACAGACAATATTCAAATCCAAGTATTGGCCTATTTGGAAAGGTTGTAGCTTTGTCTATGAATAAACCTTTCGACCAAGTGTTAGAAAAAACAATTTTTCCGGCCCTTGGCTTAAAACATAGCTATGTAAATGTACCTAAGACCCAAATGCAAAACTATGCTTTTGGCTATAACCAAGAAAATCAGCCGATTCGAGTTAACCCCGGCCCACTCGATGCCCCAGCATATGGCGTCCCAGCATATGGCGTCAAATCGACACTACCCGACATGTTGAGTTTTATTCATGCCAACCTTAACCCACAGGAATATCCGGCAGATATTCAACGGGCAATTAATGAAACACATCAAGGGTTCTATCAAGCAAATACCATGTATCAGGCACTCGGTTGGGAAGAGTTTTCTTATCCGGCAACGTTACAAACTTTATTAGACAGTAATTCAGAACAGATTGTGATGAAACCTAATAAAGTGACTGCTATTTCAAAGGAACCTTCAGTTAAGATGTACCATAAAACTGGCTCAACTAACGGTTTCGGAACATATGTAGTGTTTATTCCTAAAGAAAATATTGGTTTAGTCACGTTAACCAATAAACGTATTCCAAATGAAGAGCGCATTAAGGCAGCTTATGCTGTGCTGAATGCAATAAAGAAATAA", "partial": "0", "query_start": 1852, "query_end": 2628, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.03}, "gnl|BL_ORD_ID|1336|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1422", "ARO_accession": "3001817", "ARO_name": "ACC-3", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.77255e-59, "max_identities": 99, "bit_score": 191.43, "cvterm_id": "36784", "query": "MKKSLSATL----ISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY-KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M+K +  TL    +   LA +A G  A++     +   VDS I+PLM + +IPGM+VAV++ GK Y +NYG A  Q +QPVT+NTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  I++L+  T+T  GL L +P+ VK+   L+ + + W+P+   G  R+Y+N   GL G + A + GM YE  +   +L  LG++HT++ VP      YA+GY K  +P+ V+   L  E+YG+++ + D++R+ + NM", "sequence_from_db": "MRKKMQNTLKMLSVITCLALTAQGAMASEMDQAKIKDTVDSLIQPLMQKNNIPGMSVAVTLNGKNYIYNYGLASKQPQQPVTDNTLFEVGSLSKTFAATLASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTT-GLALFMPEEVKNTDQLMAYLKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDAIEKTLLPKLGMTHTYLNVPADQAENYAWGYNKKNEPIHVNMEVLGNEAYGIRTNASDLIRYVQANM", "sequence_from_broadstreet": "MRKKMQNTLKMLSVITCLALTAQGAMASEMDQAKIKDTVDSLIQPLMQKNNIPGMSVAVTLNGKNYIYNYGLASKQPQQPVTDNTLFEVGSLSKTFAATLASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTTGLALFMPEEVKNTDQLMAYLKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDAIEKTLLPKLGMTHTYLNVPADQAENYAWGYNKKNEPIHVNMEVLGNEAYGIRTNASDLIRYVQANMGQLKLDGNSTLQKALTDTHIGYFKSGKITQDLMWEQLPYPVSLPDLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVT", "dna_sequence_from_broadstreet": "ATGCGTAAAAAAATGCAGAACACCTTGAAGATGTTATCCGTGATTACCTGTCTGGCTTTAACGGCTCAGGGTGCCATGGCGTCAGAAATGGATCAGGCCAAAATTAAAGACACCGTTGATAGCCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCGGGCATGTCGGTGGCAGTTACGCTGAACGGTAAAAATTATATTTATAACTATGGCTTAGCCTCCAAACAGCCCCAGCAGCCCGTAACGGACAACACGCTATTTGAAGTTGGCTCGCTGAGCAAAACCTTTGCAGCGACGCTGGCGTCTTATGCACAGGTCAGCGGCAAGTTATCGCTGGATAAAAGCATTAGCCATTATGTTCCAGAACTGCGCGGCAGCAGCTTCGATCACATTAGCGTGCTGAATGCGGGAACGCATACCACAGGTTTAGCGCTGTTCATGCCTGAAGAAGTGAAAAACACCGATCAGCTGATGGCTTATCTGAAAGCGTGGAAACCCGCCGATCCTGCGGGGACTCACCGTGTTTATTCCAATATTGGTACCGGCTTGTTGGGCATGATTGCCGCGCAAAGCATGGGAATGACTTACGAAGATGCGATTGAGAAAACGCTCCTTCCGAAGTTGGGCATGACGCACACCTATCTTAATGTTCCAGCAGACCAAGCGGAAAATTATGCTTGGGGCTATAACAAAAAGAATGAGCCGATCCACGTTAATATGGAAGTGTTGGGCAACGAAGCCTATGGCATTAGAACCAATGCGAGTGACCTGATTCGCTATGTGCAAGCCAATATGGGGCAGCTAAAACTTGATGGAAATTCGACGCTGCAAAAAGCGCTCACCGACACGCATATCGGTTACTTCAAGTCAGGCAAAATCACTCAGGATCTGATGTGGGAACAGCTGCCATATCCGGTATCTCTGCCGGATCTGCTCACTGGCAACGATATGGCGATGACAAAAAGCGTTGCTACGCCGATTGTTCCACCGCTGCCACCACAGGAAAATGTATGGATTAACAAAACCGGTTCCACCAATGGTTTTGGTGCCTACATCGCATTTGTTCCGGCTAAAAAGATGGGTATCGTGATGCTGGCGAACAAGAACTACTCTATCGATCAGCGTGTAACG", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 37.22}, "gnl|BL_ORD_ID|1569|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1663", "ARO_accession": "3001815", "ARO_name": "ACC-1", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.2332e-58, "max_identities": 98, "bit_score": 190.66, "cvterm_id": "35915", "query": "MKKSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M+ +L    +   LA +  G  AA+     +   VD  I+PLM + +IPGM+VAV+V GK Y +NYG A  Q +QPVTENTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   +L  LG+ H+++ VP      YA+GY  K +PV V+   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK", "dna_sequence_from_broadstreet": "ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGTCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGGTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGTGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCGCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 37.4}, "gnl|BL_ORD_ID|1909|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2024", "ARO_accession": "3001816", "ARO_name": "ACC-2", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.58333e-58, "max_identities": 91, "bit_score": 189.504, "cvterm_id": "36784", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+   VD  I+PLM + +IPGM+VAV+++G+ Y +NYG A  Q +QPVTENTLFE+GS+SKTF  +L + + A  +++L    + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   IL  LG++ T++ VP      YA+GY  K +PV V+   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "IKDTVDGLIQPLMQKNNIPGMSVAVTIRGRNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAAILASYAQASGKLSLEQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMTYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEQTILPLLGMNQTYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MRKKMQNTLKLLSVITCLAATAQGAMAANIDESKIKDTVDGLIQPLMQKNNIPGMSVAVTIRGRNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAAILASYAQASGKLSLEQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMTYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEQTILPLLGMNQTYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDGNAKIQHALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEVNK", "dna_sequence_from_broadstreet": "ATGCGTAAAAAAATGCAGAACACCTTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGCCCAAGGTGCTATGGCTGCCAATATCGATGAGAGCAAAATTAAAGACACCGTCGATGGCCTAATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCATCAGAGGTAGGAACTATATTTATAACTACGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTGACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCATCTTGGCGTCCTATGCGCAGGCGAGCGGTAAGCTGTCTTTGGAGCAAAGCGTTAGCCACTATGTTCCAGAACTACGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGTACGCATACCTCAGGTCTACAGCTGTTTATGCCGGAAGATATCAAGAACACCACACAGCTGATGACTTATCTAAAAGCATGGAAACCTGCTGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACCGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGCAAACCATCCTTCCTCTATTAGGCATGAATCAAACCTACCTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGTCAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGGTAATGCCAAGATCCAACATGCACTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCAGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCCCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAACGAGTGACGGTGGCGTATAAAATCCTGAGCTCGTTGGAAGTGAATAAGTAG", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.22}, "gnl|BL_ORD_ID|376|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "406", "ARO_accession": "3001818", "ARO_name": "ACC-4", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.94289e-57, "max_identities": 97, "bit_score": 187.578, "cvterm_id": "35914", "query": "MKKSLSATLISALLAFSAPGFSAAD----NVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "M+ +L    +   LA +  G  AA+     +   VD  I+PLM + +IPGM+VAV+V GK Y +NYG A  Q +QPVTENTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   +L  LG+ H+++ VP      YA+GY  K +PV  +   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK", "dna_sequence_from_broadstreet": "ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGTCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGGTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGGGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGCGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACAGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCGCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG", "partial": "0", "query_start": 1846, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 37.02}, "gnl|BL_ORD_ID|1762|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "ACC-5", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "1865", "ARO_accession": "3001819", "ARO_name": "ACC-5", "ARO_category": {"36212": {"category_aro_accession": "3000073", "category_aro_cvterm_id": "36212", "category_aro_name": "ACC beta-lactamase", "category_aro_description": "ACC beta-lactamases or Ambler class C beta-lactamases are AmpC beta-lactamases. They possess an interesting resistance phenotype due to their low activity against cephamycins.", "category_aro_class_name": "AMR Gene Family"}, "35923": {"category_aro_accession": "0000004", "category_aro_cvterm_id": "35923", "category_aro_name": "monobactam", "category_aro_description": "Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Unlike penams and cephems, monobactams do not have any ring fused to its four-member lactam structure. Monobactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.32808e-57, "max_identities": 91, "bit_score": 187.578, "cvterm_id": "36784", "query": "VAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNK-KPVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "+   VD  I+PLM + +IPGM+VAV+V GK Y +NYG A  Q +QPVTENTLFE+GS+SKTF   L + +    +++L+   + Y PEL    +  +++L++ T+T+ GL L +P+ +K+   L+ + + W+P+   G  R+Y+N   GL G + A + G+ YE  +   +L  LG+ H+++ VP      YA+GY  K +PV V+   L  E+YG+K+ S D+LR+ + NM", "sequence_from_db": "IKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQLSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTS-GLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANM", "sequence_from_broadstreet": "MQNTLKLLSVITCLAATAQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQLSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK", "dna_sequence_from_broadstreet": "ATGCAGAACACATTGAAGCTGTTATCCGTGATTACCTGTCTGGCAGCAACTGCCCAAGGTGCTCTGGCTGCTAATATCGATGAGAGCAAAATTAAAGACACCGTTGATGACCTGATCCAGCCGCTGATGCAGAAGAATAATATTCCCGGTATGTCGGTCGCAGTGACCGTCAACGGTAAAAACTACATTTATAACTATGGGTTAGCGGCAAAACAGCCTCAGCAGCCGGTTACGGAAAATACGTTATTTGAAGTGGGTTCGCTGAGTAAAACGTTTGCTGCCACCTTGGCGTCCTATGCGCAGTTGAGCGGTAAGCTGTCTTTGGATCAAAGCGTTAGCCATTACGTTCCAGAGTTGCGTGGCAGCAGCTTTGACCACGTTAGCGTACTCAATGTGGGCACGCATACCTCAGGCCTACAGCTATTTATGCCGGAAGATATTAAAAATACCACACAGCTGATGGCTTATCTAAAAGCATGGAAACCTGCCGATGCGGCTGGAACCCATCGCGTTTATTCCAATATCGGTACTGGTTTGCTAGGGATGATTGCGGCGAAAAGTCTGGGTGTGAGCTATGAAGATGCGATTGAGAAAACCCTCCTTCCTCAGTTAGGCATGCATCACAGCTACTTGAAGGTTCCGGCTGACCAGATGGAAAACTATGCGTGGGGCTACAACAAGAAAGATGAGCCAGTGCACGTGAATATGGAGATTTTGGGTAACGAAGCTTATGGTATCAAAACCACCTCCAGTGACTTGTTACGCTACGTGCAAGCCAATATGGGGCAGTTAAAGCTTGATGCTAATGCCAAGATGCAACAGGCTCTGACTGCCACCCACACCGGCTATTTCAAATCGGGTGAGATTACTCAGGATCTGATGTGGGAGCAGCTGCCATATCCGGTTTCTCTGCCGAATTTGCTCACCGGTAACGATATGGCGATGACGAAAAGCGTGGCTACGCCGATTGTTCCCCCGTTACCGCCACAGGAAAATGTGTGGATTAATAAGACCGGATCAACTAACGGCTTCGGTGCCTATATTGCGTTTGTTCCTGCTAAGAAGATGGGGATCGTGATGCTGGCTAACAAAAACTACTCAATCGATCAGCGAGTGACGGTGGCGTATAAAATCCTGAGCTCATTGGAAGGGAATAAGTAG", "partial": "0", "query_start": 1924, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 39.22}, "gnl|BL_ORD_ID|2506|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Rhodobacter sphaeroides ampC beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2844", "ARO_accession": "3004291", "ARO_name": "Rhodobacter sphaeroides ampC beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "36976": {"category_aro_accession": "3000632", "category_aro_cvterm_id": "36976", "category_aro_name": "benzylpenicillin", "category_aro_description": "Benzylpenicillin, commonly referred to as penicillin G, is effective against both Gram-positive and Gram-negative bacteria. It is unstable in acid.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.28114e-54, "max_identities": 95, "bit_score": 178.333, "cvterm_id": "41456", "query": "LMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKK--PVRVSPGQLDAESYGVKSASKDMLRWAEMNM", "match": "++ + DIPG+ V V+  G+  ++  G A  + +QPVT +TLFELGS+SK F   L A++  +  ++L+ P A Y P L       +TL+DLAT+  GGLPLQVPD V     L+++ + W+P  +PG  R Y+N SIGL G +TA   GM Y       I   LGL  T+I VP  A  +YA+GY  K   P RV+PG LD E+YGVKS+++DML   ++ +", "sequence_from_db": "VIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLFELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRPP-EPG-TRSYSNISIGLLGHITAGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEAYGVKSSARDMLTLLDLEL", "sequence_from_broadstreet": "MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLFELGSISKIFNVTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRPPEPGTRSYSNISIGLLGHITAGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEAYGVKSSARDMLTLLDLELGTGTASPEVQTAVATTQEGRFQTRLYTQAMIWEAYPWPVDPERLVEGNGYDFILQPQPVDEVDTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRNYPNEARVRATYDLITHILAE", "dna_sequence_from_broadstreet": "ATGAAGCACCTTTCCCCCCTCTCCATCCTGCTCATGGTGGGCGCGCTGACGCCCGCGCTTGCGCAAGACACCACGCCGTCGTTCGAGAGCGCCGCCGCCGCGGCCTTCGAGAGCGTCATCGAGGAGCATGACATTCCCGGTCTGGTGGTGGGCGTGACCCACGGCGGACGGCACAGTTTCTATCAGACAGGCTTGGCCTCACGGGAAGATCAGCAGCCGGTAACCCCTGACACGCTTTTTGAGCTCGGTTCGATCAGCAAGATCTTCAACGTGACGCTGGCGGCCTTGGCAGAGGAGCGGGGCGCGCTGTCGCTCGATGCGCCGGTCGCCGACTATCTTCCCTCCCTGCGAGGTTCTCCTGCAGGAGAGCTGACGCTGATCGATCTGGCGACGCACCATACCGGCGGCCTCCCGTTGCAGGTGCCGGACGAAGTTGCAGATGTAGATCGCCTGGTCGACTGGCTACGGAGTTGGCGACCGCCCGAGCCCGGTACGCGCAGCTATTCCAACATCAGCATCGGCCTATTGGGGCACATCACCGCGGGCGTGCTGGGCATGAGCTATGCTGATGCGTCCCAGACGGTTATCTTCCCGGCGCTCGGATTGAAGAGCACGTGGATCGACGTCCCCACCGATGCGATGGGACGCTACGCCTTCGGCTATGACCGCAAGACAGACGCGCCAACCCGGGTTACGCCCGGCGTGCTGGACGATGAAGCGTACGGGGTAAAATCCTCCGCTCGCGACATGCTGACGCTGCTCGACCTCGAGCTTGGAACCGGCACTGCCTCGCCCGAAGTTCAAACGGCGGTGGCCACCACGCAGGAGGGCCGGTTCCAGACCCGCCTGTACACGCAGGCCATGATATGGGAGGCCTATCCTTGGCCTGTCGACCCAGAGCGTCTGGTGGAGGGGAACGGGTATGACTTCATCCTCCAGCCTCAGCCTGTGGACGAGGTGGACACGACACCCGATCGGAGGGTCATCCTGAACAAGACAGGTTCCACGAACGGCTTCGGTGGGTACATCGCGATCGTGCCAAGCGAGGATCTGGGCGTCGTCGTCCTTGCCAACCGCAACTACCCCAACGAGGCGCGGGTTCGAGCCACTTACGACCTGATCACTCACATCTTGGCCGAATAA", "partial": "0", "query_start": 1957, "query_end": 2616, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 42.79}, "gnl|BL_ORD_ID|2080|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampH", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3307", "ARO_accession": "3004612", "ARO_name": "Escherichia coli ampH beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.90189e-13, "max_identities": 72, "bit_score": 67.0106, "cvterm_id": "42578", "query": "MKKSL--SATLISALL--AFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELA-LPQWKG--ITLLDLATYTAGGLPLQVPDAVKSRADLL--NFYQQWQ------PSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAE", "match": "MK+SL  SA L +A L    +A   +  +  + +VD     +       GMA+ V    +  + +YG            +++  + S++K  T  +    + +  + LNDP +KY P  A +P + G  ITL++LAT+T+  LP + P     R   +     Q+W+          PG    Y+N +  L     ANA+G PY QL   +I  PLG+  T  T       +     +   P   +   +   S GV S   DM+RW +", "sequence_from_db": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSA-LPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIG--SGGVYSTPGDMMRWMQ", "sequence_from_broadstreet": "MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADHIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS", "dna_sequence_from_broadstreet": "TTGAAACGTAGTCTGCTTTTTTCTGCCGTGCTGTGTGCGGCGTCATTGACCTCCGTCCATGCGGCGCAGCCGATCACTGAACCGGAGTTTGCCTCTGATATTGTCGATCGTTATGCCGATCATATTTTTTACGGCAGCGGTGCCACGGGGATGGCTCTGGTTGTTATCGACGGTAACCAGCGCGTCTTTCGCAGTTATGGCGAAACGCGACCTGGTAATAACGTTCGCCCGCAGCTGGATTCGGTCGTGCGTATTGCTTCCCTCACCAAGCTAATGACCAGTGAGATGCTGGTGAAATTGCTCGACCAGGGGACCGTGAAGTTAAACGATCCGCTAAGTAAATATGCTCCGCCAGGCGCACGCGTGCCAACCTACAATGGGACGCCCATTACGCTGGTCAATCTGGCAACCCATACCAGCGCCCTGCCCCGTGAACAGCCCGGTGGCGCGGCACATCGTCCGGTGTTTGTCTGGCCAACGCGCGAGCAACGCTGGAAATACCTTTCTACGGCGAAGCTGAAAGCCGCGCCAGGCAGTCAGGCGGCGTACTCTAACCTTGCGTTCGACCTGCTGGCAGATGCACTGGCGAATGCGTCCGGCAAGCCTTATACCCAGTTGTTTGAAGAGCAGATTACCCGTCCATTGGGGATGAAAGACACCACCTACACCCCCTCACCGGATCAGTGCCGCCGTTTAATGGTTGCTGAGCGCGGTGCCAGTCCGTGCAATAACACGCTGGCGGCAATTGGCAGCGGCGGCGTCTATTCCACGCCTGGCGATATGATGCGCTGGATGCAGCAGTATTTGTCATCTGATTTTTATCAGCGCAGTAACCAGGCAGATCGCATGCAGACGTTGATTTATCAGCGCGCGCAGTTTACGAAAGTGATTGGCATGGATGTCCCCGGCAAAGCGGATGCGCTTGGTTTAGGTTGGGTATATATGGCCCCGAAAGAGGGTCGTCCGGGGATTATTCAGAAGACAGGCGGTGGTGGCGGTTTCATTACCTATATGGCGATGATCCCGCAGAAGAATATTGGCGCGTTTGTGGTGGTCACTCGTTCGCCGTTGACGCGCTTTAAAAATATGAGCGATGGCATCAATGACCTGGTGACCGAGCTAAGCGGGAATAAACCGTTGGTTATCCCCGCGTCCTGA", "partial": "0", "query_start": 1846, "query_end": 2607, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 26.77}, "gnl|BL_ORD_ID|1968|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "Escherichia coli ampC1 beta-lactamase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "3306", "ARO_accession": "3004611", "ARO_name": "Escherichia coli ampC1 beta-lactamase", "ARO_category": {"41396": {"category_aro_accession": "3004232", "category_aro_cvterm_id": "41396", "category_aro_name": "ampC-type beta-lactamase", "category_aro_description": "AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.000134295, "max_identities": 39, "bit_score": 39.6614, "cvterm_id": "41021", "query": "KQPV--TENTLFELGSVSKTF-TGVLGAVSVAKKEMALNDPAAKYQPELAL---PQWKGITLLDLAT--YTAGGLPL--QVPDAV-------KSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHT", "match": "+QPV  T  TL++L S +K + T       +++ ++  +D  AKY P  A       KG   L ++   + +GG P   Q P+         + +   L   ++     +PG   +Y++    L G +  +  G P ++ +   I  PLGL+HT", "sequence_from_db": "EQPVKATTGTLYDLASNTKMYATNFALQKLMSEGKLHPDDRIAKYIPGFADSPNDTIKGKNTLRISDLLHHSGGFPADPQYPNKAVAGALYSQDKGQTLEMIKRTPLEYQPGSKHIYSDVDYMLLGFIVESVTGQPLDRYVEESIYRPLGLTHT", "sequence_from_broadstreet": "MKRTMLYLSLLAVSCSVSAAKYPVLTESSPEKAGFNVERLNQMDRWISQQVDVGYPSVNLLIIKDNQIVYRKAWGAAKKYDGSVLMEQPVKATTGTLYDLASNTKMYATNFALQKLMSEGKLHPDDRIAKYIPGFADSPNDTIKGKNTLRISDLLHHSGGFPADPQYPNKAVAGALYSQDKGQTLEMIKRTPLEYQPGSKHIYSDVDYMLLGFIVESVTGQPLDRYVEESIYRPLGLTHTVFNPLLKGFKPQQIAATELNGNTRDGVIHFPNIRTSTLWGQVHDEKAFYSMGGVSGHAGLFSNTGDIAVLMQTMLNGGGYGDVQLFNAETVKMFTTSSKEDATFGLGWRVNGNATMTPTFGTLASPQTYGHTGWTGTVTVIDPVNHMTIVMLSNKPHSPVADPQKNPNMFESGQLPIATYGWVVDQVYAALKQK", "dna_sequence_from_broadstreet": "ATGAAACGGACAATGCTCTATCTTTCTCTGCTGGCTGTTAGTTGTAGCGTCAGCGCCGCAAAATACCCTGTTCTGACAGAAAGCTCGCCAGAGAAAGCAGGGTTTAACGTCGAACGGCTTAACCAGATGGATCGCTGGATTAGCCAGCAAGTTGATGTCGGTTATCCCAGCGTAAACCTGCTGATCATTAAAGATAATCAGATTGTGTATCGCAAAGCCTGGGGAGCGGCGAAAAAGTACGATGGCAGCGTGTTGATGGAACAGCCTGTCAAAGCCACCACCGGGACGCTGTATGACCTGGCCTCAAACACCAAAATGTACGCCACGAACTTCGCCCTGCAAAAGCTGATGAGCGAAGGCAAACTGCATCCTGACGATCGGATTGCGAAATATATTCCGGGGTTTGCCGATAGTCCAAATGACACCATTAAAGGCAAAAACACCCTGCGGATTTCTGACCTGCTGCATCACAGCGGCGGTTTCCCGGCAGATCCGCAATACCCGAATAAAGCGGTCGCGGGCGCGTTATATTCCCAGGATAAAGGCCAGACGCTGGAGATGATCAAGCGCACGCCGCTGGAATATCAGCCCGGCAGCAAACATATCTACAGCGATGTCGATTATATGCTGCTTGGATTTATCGTCGAGTCGGTTACCGGTCAGCCGCTTGACCGCTATGTTGAAGAGTCGATTTATCGCCCGCTCGGCCTGACACATACGGTATTTAACCCGCTGCTGAAAGGCTTTAAACCGCAACAAATTGCCGCCACGGAATTGAACGGCAATACCCGCGATGGCGTGATCCATTTCCCGAATATCCGCACCTCCACTCTCTGGGGTCAGGTGCACGATGAAAAAGCCTTTTATTCGATGGGCGGCGTTTCCGGGCACGCAGGTTTGTTTTCCAATACCGGCGATATTGCGGTGTTAATGCAAACGATGCTGAACGGCGGGGGCTATGGTGATGTGCAGCTGTTCAATGCGGAAACGGTGAAGATGTTCACCACCAGCTCTAAGGAAGATGCCACTTTTGGCCTCGGCTGGCGCGTGAATGGTAATGCCACCATGACGCCGACGTTTGGCACGCTGGCAAGCCCGCAAACCTACGGTCACACTGGCTGGACCGGAACGGTGACCGTTATCGATCCGGTGAATCATATGACGATTGTGATGTTAAGCAACAAGCCACATTCGCCGGTTGCCGATCCGCAAAAGAATCCCAATATGTTCGAAAGCGGTCAGTTGCCGATTGCAACTTATGGTTGGGTAGTTGATCAGGTGTATGCGGCGTTAAAGCAGAAGTAA", "partial": "0", "query_start": 2053, "query_end": 2463, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 25.32}, "gnl|BL_ORD_ID|712|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1846, "orf_end": 2862, "orf_from": "NODE_44_length_4295_cov_23.2123_3 ", "model_name": "OXA-198", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "758", "ARO_accession": "3001805", "ARO_name": "OXA-198", "ARO_category": {"36026": {"category_aro_accession": "3000017", "category_aro_cvterm_id": "36026", "category_aro_name": "OXA beta-lactamase", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0309057, "max_identities": 38, "bit_score": 31.9574, "cvterm_id": "36752", "query": "MKKSLSATLISALLAF--SAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVK-GKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPEL-ALPQW", "match": "M K +S   I A LAF  S P        AA  D T+  L AQQ I G  V  S+  GK +  N    D +AKQ           S + TF  +   +S+ +K ++  D   K+   +   P W", "sequence_from_db": "MHKHMSKLFI-AFLAFLLSVP--------AAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHN----DPRAKQRF---------STASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDW", "sequence_from_broadstreet": "MHKHMSKLFIAFLAFLLSVPAAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHNDPRAKQRFSTASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDWNRDQTLESAFKVSCVWCYQALARQVGAEKYRNYLRKSVYGELREPFEETTFWLDGSLQISAIEQVNFLKKVHLRTLPFSASSYETLRQIMLIEQTPAFTLRAKTGWATRVKPQVGWYVGHVETPTDVWFFATNIEVRDEKDLPLRQKLTRKALQAKGIIE", "dna_sequence_from_broadstreet": "ATGCATAAACACATGAGTAAGCTCTTCATCGCTTTTTTAGCCTTTCTGCTGTCGGTGCCAGCAGCCGCTGAAGACCAGACACTTGCCGAGCTCTTTGCCCAACAAGGCATTGACGGGACTATAGTGATTTCGTCGCTACACAACGGAAAGACATTTATCCACAACGATCCCCGCGCAAAACAGAGATTCTCGACAGCATCCACGTTCAAGATACTGAACACGCTGATCTCGCTCGAAGAAAAAGCCATCTCTGGAAAAGACGATGTGCTGAAATGGGACGGGCATATTTACGATTTTCCAGATTGGAATCGTGACCAGACGCTAGAAAGTGCGTTCAAGGTTTCCTGTGTCTGGTGTTATCAGGCGCTTGCACGCCAGGTCGGCGCGGAGAAGTATCGAAATTATTTACGCAAGTCAGTTTACGGAGAATTACGCGAGCCTTTTGAGGAAACAACATTCTGGCTTGATGGTTCACTTCAAATCAGCGCAATTGAACAAGTGAATTTCCTCAAGAAAGTTCATCTGCGCACTCTCCCATTCAGTGCATCGTCCTACGAAACGCTACGACAAATCATGCTTATCGAGCAAACGCCGGCTTTTACGCTGCGGGCCAAGACAGGCTGGGCAACAAGAGTAAAGCCGCAAGTTGGCTGGTATGTGGGCCATGTCGAAACTCCAACGGATGTATGGTTCTTTGCCACGAATATTGAAGTCCGTGACGAAAAAGACTTGCCCTTACGTCAGAAGCTAACGCGAAAAGCATTACAAGCAAAGGGGATCATCGAATAA", "partial": "0", "query_start": 1846, "query_end": 2205, "orf_dna_sequence": "ATGAAAAAATCGTTATCTGCAACACTGATTTCCGCTCTGCTGGCGTTTTCCGCCCCGGGGTTTTCTGCCGCTGATAATGTCGCGGCGGTGGTGGACAGCACCATTAAACCGCTGATGGCACAGCAGGATATTCCCGGGATGGCGGTTGCCGTCTCCGTAAAGGGTAAGCCCTATTATTTCAATTATGGTTTTGCCGATATTCAGGCAAAACAGCCGGTCACTGAAAATACACTATTTGAGCTCGGATCTGTAAGTAAAACTTTCACAGGTGTGCTGGGTGCGGTTTCTGTGGCGAAAAAAGAGATGGCGCTGAATGATCCGGCGGCAAAATACCAGCCGGAGCTGGCTCTGCCGCAGTGGAAGGGGATCACATTGCTGGATCTGGCTACCTATACCGCAGGCGGACTGCCGTTACAGGTGCCGGATGCGGTAAAAAGCCGTGCGGATCTGCTGAATTTCTATCAGCAGTGGCAGCCGTCCCGGAAACCGGGCGATATGCGTCTGTATGCAAACAGCAGTATCGGCCTGTTTGGTGCTCTGACCGCAAACGCGGCGGGGATGCCGTATGAGCAGTTGCTGACTGCACGGATCCTGGCACCGCTGGGGTTATCTCACACCTTTATTACTGTGCCGGAAAGTGCGCAAAGCCAGTATGCGTACGGTTATAAAAACAAAAAACCGGTCCGCGTGTCGCCGGGACAGCTTGATGCGGAATCTTACGGCGTGAAATCCGCCTCAAAAGATATGCTGCGCTGGGCGGAAATGAATATGGAGCCGTCACGGGCCGGTAATGCGGGCGCGCTTTCGACGCCGCTGGAGGTATCGACCAGCGGCGCTCCGGTGCGCGCAATCGCCTCGGCAACATTCGTCGGATTTAGCCCGCCTGCCAGCCCCCACGGCAAGGCACCGCGATATCCGGCCAGCAGCGACCAGTCGAACGCCAACCCCATGCCGCCGGGCAGCGCGCCTTTGGGGGTCTTGGCGTCGAACAAGATCAAGTCCGCCGCCCCGGCATAG", "orf_prot_sequence": "MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNAGALSTPLEVSTSGAPVRAIASATFVGFSPPASPHGKAPRYPASSDQSNANPMPPGSAPLGVLASNKIKSAAPA", "perc_identity": 30.65}}, "NODE_47_length_3813_cov_27.9457_4 # 2763 # 3638 # -1 # ID=47_4;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.550": {"gnl|BL_ORD_ID|1919|hsp_num:0": {"type_match": "Perfect", "model_id": "2035", "orf_strand": "-", "orf_start": 2763, "orf_end": 3638, "orf_from": "NODE_47_length_3813_cov_27.9457_4", "model_name": "CTX-M-15", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3001878", "ARO_name": "CTX-M-15", "ARO_category": {"36025": {"category_aro_accession": "3000016", "category_aro_cvterm_id": "36025", "category_aro_name": "CTX-M beta-lactamase", "category_aro_description": "These enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime.  CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam.", "category_aro_class_name": "AMR Gene Family"}, "35977": {"category_aro_accession": "0000060", "category_aro_cvterm_id": "35977", "category_aro_name": "ceftazidime", "category_aro_description": "Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections.", "category_aro_class_name": "Antibiotic"}, "35979": {"category_aro_accession": "0000062", "category_aro_cvterm_id": "35979", "category_aro_name": "ceftriaxone", "category_aro_description": "Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 593.578, "max_identities": 291, "cvterm_id": "35914", "query": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "match": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "sequence_from_db": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "sequence_from_broadstreet": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "dna_sequence_from_broadstreet": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "partial": "0", "query_start": 2763, "query_end": 3635, "orf_dna_sequence": "ATGGTTAAAAAATCACTGCGCCAGTTCACGCTGATGGCGACGGCAACCGTCACGCTGTTGTTAGGAAGTGTGCCGCTGTATGCGCAAACGGCGGACGTACAGCAAAAACTTGCCGAATTAGAGCGGCAGTCGGGAGGCAGACTGGGTGTGGCATTGATTAACACAGCAGATAATTCGCAAATACTTTATCGTGCTGATGAGCGCTTTGCGATGTGCAGCACCAGTAAAGTGATGGCCGCGGCCGCGGTGCTGAAGAAAAGTGAAAGCGAACCGAATCTGTTAAATCAGCGAGTTGAGATCAAAAAATCTGACCTTGTTAACTATAATCCGATTGCGGAAAAGCACGTCAATGGGACGATGTCACTGGCTGAGCTTAGCGCGGCCGCGCTACAGTACAGCGATAACGTGGCGATGAATAAGCTGATTGCTCACGTTGGCGGCCCGGCTAGCGTCACCGCGTTCGCCCGACAGCTGGGAGACGAAACGTTCCGTCTCGACCGTACCGAGCCGACGTTAAACACCGCCATTCCGGGCGATCCGCGTGATACCACTTCACCTCGGGCAATGGCGCAAACTCTGCGGAATCTGACGCTGGGTAAAGCATTGGGCGACAGCCAACGGGCGCAGCTGGTGACATGGATGAAAGGCAATACCACCGGTGCAGCGAGCATTCAGGCTGGACTGCCTGCTTCCTGGGTTGTGGGGGATAAAACCGGCAGCGGTGGCTATGGCACCACCAACGATATCGCGGTGATCTGGCCAAAAGATCGTGCGCCGCTGATTCTGGTCACTTACTTCACCCAGCCTCAACCTAAGGCAGAAAGCCGTCGCGATGTATTAGCGTCGGCGGCTAAAATCGTCACCGACGGTTTGTAA", "orf_prot_sequence": "MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL", "perc_identity": 100.0}}, "NODE_51_length_1731_cov_22.5767_1 # 196 # 1026 # 1 # ID=51_1;partial=00;start_type=ATG;rbs_motif=ATA;rbs_spacer=6bp;gc_cont=0.345": {"gnl|BL_ORD_ID|1846|hsp_num:0": {"type_match": "Perfect", "model_id": "1952", "orf_strand": "+", "orf_start": 196, "orf_end": 1026, "orf_from": "NODE_51_length_1731_cov_22.5767_1", "model_name": "OXA-1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3001396", "ARO_name": "OXA-1", "ARO_category": {"35994": {"category_aro_accession": "0000077", "category_aro_cvterm_id": "35994", "category_aro_name": "tazobactam", "category_aro_description": "Tazobactam is a compound which inhibits the action of bacterial beta-lactamases.", "category_aro_class_name": "Adjuvant"}, "36026": {"category_aro_accession": "3000017", "category_aro_cvterm_id": "36026", "category_aro_name": "OXA beta-lactamase", "category_aro_description": "OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.", "category_aro_class_name": "AMR Gene Family"}, "35981": {"category_aro_accession": "0000064", "category_aro_cvterm_id": "35981", "category_aro_name": "amoxicillin", "category_aro_description": "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.", "category_aro_class_name": "Antibiotic"}, "35995": {"category_aro_accession": "0000078", "category_aro_cvterm_id": "35995", "category_aro_name": "piperacillin", "category_aro_description": "Piperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "40951": {"category_aro_accession": "3004021", "category_aro_cvterm_id": "40951", "category_aro_name": "piperacillin-tazobactam", "category_aro_description": "An antibiotic cocktail containing the penam beta-lactam antibiotic Piperacillin and the beta-lactamase inhibitor Tazobactam.", "category_aro_class_name": "Antibiotic"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 564.303, "max_identities": 276, "cvterm_id": "35915", "query": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "match": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "sequence_from_db": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "sequence_from_broadstreet": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA", "partial": "0", "query_start": 196, "query_end": 1023, "orf_dna_sequence": "ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTACAGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACTGAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAAGCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATGGCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAAGGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTTTGGGTTTCGCAAGAAATAACCCAAAAAATTGGATTAAATAAAATCAAGAATTATCTCAAAGATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACAGAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGTAAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAACATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTCACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGACATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGCATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA", "orf_prot_sequence": "MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL", "perc_identity": 100.0}}, "NODE_51_length_1731_cov_22.5767_2 # 1164 # 1712 # 1 # ID=51_2;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.494": {"gnl|BL_ORD_ID|134|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "150", "ARO_accession": "3002676", "ARO_name": "catB3", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.4043e-109, "max_identities": 147, "bit_score": 308.145, "cvterm_id": "36884", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "sequence_from_db": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "sequence_from_broadstreet": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVEPYAIVGGNPAKKIKKRFTDEEISLLLEMEWWNWSLEKIKAAMPMLCSSNIVGLHKYWLEFAV", "dna_sequence_from_broadstreet": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGAGCCTTACGCTATCGTTGGCGGCAATCCCGCTAAGAAGATTAAGAAACGCTTCACCGATGAGGAAATTTCATTGCTTCTGGAGATGGAGTGGTGGAATTGGTCACTGGAGAAGATCAAAGCGGCAATGCCCATGCTGTGCTCGTCTAATATTGTTGGCCTGCACAAGTATTGGCTCGAGTTTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|413|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "446", "ARO_accession": "3002680", "ARO_name": "catB8", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.05722e-89, "max_identities": 135, "bit_score": 257.299, "cvterm_id": "35731", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "M NYF+SPFKG+LLSEQVKNPNI+VGRYSYYSGYYHGHSFD+CARYL PDRDDVDKLIIGSFCSIGSGASFIMAGNQGHR+DWASSFPFFYMQEEPAFS ALDAFQ+AG+TVIGNDVWIGSEAM+MPGIKIG GAVIGSRSLVTKDV", "sequence_from_db": "MKNYFNSPFKGELLSEQVKNPNIRVGRYSYYSGYYHGHSFDECARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWASSFPFFYMQEEPAFSRALDAFQRAGDTVIGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTKDV", "sequence_from_broadstreet": "MKNYFNSPFKGELLSEQVKNPNIRVGRYSYYSGYYHGHSFDECARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWASSFPFFYMQEEPAFSRALDAFQRAGDTVIGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTKDVEPYAIIGGNPAKQIKKRFSDEEISLLMEMEWWNWPLDKIKTAMPLLCSSNIFGLHKYWREFAV", "dna_sequence_from_broadstreet": "ATGAAAAACTACTTTAACAGCCCTTTCAAAGGGGAACTTCTTTCTGAGCAAGTGAAAAATCCAAATATCAGAGTAGGCCGGTATAGCTATTACTCTGGCTACTATCACGGGCACTCATTTGATGAATGCGCGCGATACTTGCTTCCAGATCGTGATGACGTTGATAAATTGATCATTGGCAGCTTTTGTTCTATAGGAAGCGGGGCTTCCTTCATCATGGCTGGCAATCAGGGGCATCGGCATGACTGGGCATCATCCTTCCCCTTCTTCTATATGCAAGAGGAGCCTGCTTTCTCAAGAGCACTCGACGCCTTCCAAAGAGCAGGTGATACCGTCATTGGCAATGATGTCTGGATAGGCTCGGAGGCAATGATTATGCCTGGCATCAAAATTGGAGACGGTGCCGTGATAGGTAGTCGCTCGTTGGTGACAAAAGATGTAGAGCCTTATGCCATCATCGGGGGAAATCCCGCAAAGCAAATTAAGAAGCGCTTCTCCGATGAGGAAATCTCATTGCTCATGGAGATGGAGTGGTGGAACTGGCCACTAGATAAAATTAAGACAGCAATGCCTCTGCTGTGCTCGTCAAATATTTTTGGTCTGCATAAGTATTGGCGCGAGTTTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 91.84}, "gnl|BL_ORD_ID|669|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB2", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "712", "ARO_accession": "3002675", "ARO_name": "catB2", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.87251e-89, "max_identities": 131, "bit_score": 256.144, "cvterm_id": "36867", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "MTNYF+SPFKGKLL+EQVKNPNIKVGRYSYYSGYYHGHSFDDCARYL PDRDDVD+LIIGSFCSIGSGA+FIMAGNQGHRYDW SSFPFFYM EEPAF+ ++DAFQ+AG+TVIG+DVWIGSEAM+MPGIKIGHGAVIGSR+LVTKDV", "sequence_from_db": "MTNYFESPFKGKLLTEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDQLIIGSFCSIGSGAAFIMAGNQGHRYDWVSSFPFFYMNEEPAFAKSVDAFQRAGDTVIGSDVWIGSEAMIMPGIKIGHGAVIGSRALVTKDV", "sequence_from_broadstreet": "MTNYFESPFKGKLLTEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDQLIIGSFCSIGSGAAFIMAGNQGHRYDWVSSFPFFYMNEEPAFAKSVDAFQRAGDTVIGSDVWIGSEAMIMPGIKIGHGAVIGSRALVTKDVEPYTIVGGNPAKSIRKRFSEEEISMLLDMAWWDWPLEQIKEAMPFLCSSGIASLYRRWQGTSA", "dna_sequence_from_broadstreet": "ATGACGAATTATTTTGAGAGTCCCTTCAAAGGGAAGCTTCTGACTGAGCAGGTGAAGAATCCGAACATCAAGGTAGGGCGGTATAGCTACTATTCCGGCTATTACCATGGGCACTCGTTTGATGATTGTGCTCGCTACCTTCTACCAGACCGTGATGACGTTGATCAGCTGATTATCGGCAGCTTCTGCTCCATCGGATCAGGCGCAGCTTTTATTATGGCTGGGAATCAAGGCCACCGATATGATTGGGTCTCTTCTTTCCCTTTCTTCTACATGAACGAGGAGCCCGCGTTTGCAAAATCAGTCGATGCATTCCAGCGGGCTGGCGACACAGTTATAGGAAGTGATGTGTGGATCGGTTCGGAGGCCATGATCATGCCCGGGATCAAGATCGGGCATGGAGCGGTGATAGGTAGCCGCGCTTTGGTTACCAAAGACGTGGAACCCTACACCATAGTGGGGGGAAACCCTGCAAAGTCGATTAGGAAGCGCTTTTCTGAAGAAGAAATTTCTATGCTTTTAGATATGGCTTGGTGGGATTGGCCGCTGGAACAAATCAAGGAAGCAATGCCTTTTCTTTGTTCGTCTGGCATTGCCAGCCTGTATCGTCGCTGGCAAGGCACAAGCGCCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 89.12}, "gnl|BL_ORD_ID|586|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "628", "ARO_accession": "3003110", "ARO_name": "catB10", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.63679e-88, "max_identities": 129, "bit_score": 253.447, "cvterm_id": "36752", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "MTNYF+SPFKGKLL++QVKNPNIKVGRYSYYSGYYHGHSFD+CAR+L PDRDD+D+LI+GSFCSIG+GASFIMAGNQGHRYDWASSFPFFYM+EEPAFS ALDAFQKAG+TVIG+DVWIGSEAM+MPGI +GHGAVIGSR+LVTKDV", "sequence_from_db": "MTNYFESPFKGKLLADQVKNPNIKVGRYSYYSGYYHGHSFDECARFLLPDRDDIDQLIVGSFCSIGTGASFIMAGNQGHRYDWASSFPFFYMKEEPAFSGALDAFQKAGDTVIGSDVWIGSEAMIMPGINVGHGAVIGSRALVTKDV", "sequence_from_broadstreet": "MTNYFESPFKGKLLADQVKNPNIKVGRYSYYSGYYHGHSFDECARFLLPDRDDIDQLIVGSFCSIGTGASFIMAGNQGHRYDWASSFPFFYMKEEPAFSGALDAFQKAGDTVIGSDVWIGSEAMIMPGINVGHGAVIGSRALVTKDVEPYTIVGGNPAKPIKKRFSDEEIAMLLKMNWWDWPTEKIEEAMPLLCSSNIVGLHRYWQGFAV", "dna_sequence_from_broadstreet": "ATGACCAACTATTTTGAAAGTCCATTTAAAGGCAAACTGCTGGCCGACCAGGTAAAGAACCCGAACATCAAAGTCGGACGGTATAGCTATTATTCCGGCTATTACCATGGCCATTCGTTTGACGAGTGCGCTCGCTTTCTCTTGCCAGATCGCGATGACATCGACCAACTGATCGTTGGTAGCTTCTGTTCCATCGGCACGGGCGCCTCCTTCATCATGGCCGGAAATCAGGGGCACCGTTATGACTGGGCGTCTTCTTTTCCCTTCTTCTACATGAAAGAGGAGCCAGCATTCTCGGGCGCACTTGATGCATTCCAAAAAGCCGGTGACACAGTCATCGGAAGTGATGTCTGGATAGGCTCTGAGGCCATGATCATGCCCGGCATCAACGTCGGTCATGGCGCTGTGATTGGAAGCCGCGCTTTGGTCACGAAAGATGTGGAGCCGTACACTATCGTTGGCGGAAATCCCGCCAAACCGATCAAGAAACGCTTCTCCGACGAGGAGATCGCCATGCTTTTGAAAATGAATTGGTGGGATTGGCCAACTGAAAAAATTGAGGAAGCAATGCCTTTGCTATGCTCATCCAACATCGTTGGGCTGCATCGATACTGGCAAGGCTTTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 87.76}, "gnl|BL_ORD_ID|1374|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "Pseudomonas aeruginos catB6", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1316", "ARO_accession": "3002678", "ARO_name": "Pseudomonas aeruginosa catB6", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.49039e-87, "max_identities": 132, "bit_score": 252.292, "cvterm_id": "36752", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "M NYFDSPFKGKLLSEQV N NIKVGRYSYYSGYYHGHSFDDCARYL PDRDDVDKLIIGSFCSIGSGASFIMAGNQGHR+DW +SFPFFYMQEEPAFSS+ DAFQKAG+T++GNDVWIGSEAM+MPGIKIG GAVIGSRSLVT+DV", "sequence_from_db": "MENYFDSPFKGKLLSEQVTNRNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWVTSFPFFYMQEEPAFSSSTDAFQKAGDTIVGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTRDV", "sequence_from_broadstreet": "MENYFDSPFKGKLLSEQVTNRNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRHDWVTSFPFFYMQEEPAFSSSTDAFQKAGDTIVGNDVWIGSEAMIMPGIKIGDGAVIGSRSLVTRDVEPYTIIGGNPAKQIKKRFSDEEISLLMEMEWWNWPLDKIKTAMPLLCSSDIFGLHRHWRGIAV", "dna_sequence_from_broadstreet": "ATGGAAAATTACTTTGACAGTCCCTTCAAAGGGAAACTACTTTCAGAGCAAGTGACTAACCGCAACATCAAAGTTGGTCGGTACAGCTACTACTCTGGTTACTATCACGGGCATTCATTTGATGACTGCGCACGATACTTGCTCCCAGACCGTGATGACGTTGACAAACTAATCATCGGCAGCTTTTGCTCCATCGGAAGCGGGGCTTCTTTCATCATGGCGGGCAATCAGGGTCACCGGCATGACTGGGTAACATCTTTCCCTTTCTTCTACATGCAAGAAGAGCCAGCTTTTTCAAGTTCAACGGACGCCTTTCAAAAGGCCGGTGACACCATCGTCGGCAATGATGTCTGGATAGGATCAGAGGCAATGATTATGCCCGGCATCAAGATTGGAGATGGCGCGGTAATAGGCAGCCGATCGTTGGTGACGAGAGATGTAGAACCCTATACCATCATTGGCGGAAACCCTGCAAAGCAAATTAAAAAGCGATTCTCTGACGAGGAGATTTCATTACTCATGGAAATGGAGTGGTGGAACTGGCCGTTAGATAAAATCAAAACAGCTATGCCCCTTCTCTGCTCTTCAGACATTTTTGGTCTGCACAGGCATTGGCGTGGGATTGCCGTCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 89.8}, "gnl|BL_ORD_ID|2265|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "3360", "ARO_accession": "3004660", "ARO_name": "catB11", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.51536e-86, "max_identities": 128, "bit_score": 250.366, "cvterm_id": "42700", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "M NYF+SPFKGK L EQVKNPNIKVGRYSYYSGYYHGHSFDDCARYL PDRDDVDKLIIGSFCSIG+GASFIMAGNQGHRYDW +SFPFFYM EEPAFS ++DAFQ AGNTVIG+DVWIGSEAM+MPG+K+GHGAVIGSR+LVTKD+", "sequence_from_db": "MKNYFESPFKGKPLVEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGTGASFIMAGNQGHRYDWVTSFPFFYMNEEPAFSESVDAFQAAGNTVIGSDVWIGSEAMIMPGVKVGHGAVIGSRALVTKDI", "sequence_from_broadstreet": "MKNYFESPFKGKPLVEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLLPDRDDVDKLIIGSFCSIGTGASFIMAGNQGHRYDWVTSFPFFYMNEEPAFSESVDAFQAAGNTVIGSDVWIGSEAMIMPGVKVGHGAVIGSRALVTKDIEPYTIVGGNPAKEIKKRFSEQEISMLLDMKWWDWPLEQIKEAMPLLCSSDIAGLYHFWQRSSA", "dna_sequence_from_broadstreet": "ATGAAGAACTATTTTGAGAGCCCGTTTAAGGGAAAACCTCTCGTCGAACAGGTAAAGAACCCAAATATCAAGGTGGGCCGTTATAGCTATTATTCAGGCTATTACCACGGGCATTCATTTGATGATTGCGCTCGCTACCTCCTGCCTGATCGTGATGACGTTGATAAATTGATAATTGGAAGCTTTTGCTCCATAGGGACGGGTGCATCTTTTATCATGGCTGGAAATCAAGGTCACCGATATGATTGGGTTACATCATTCCCTTTTTTCTATATGAATGAGGAACCGGCATTTTCGGAATCAGTTGATGCTTTCCAGGCGGCAGGTAATACCGTCATAGGAAGCGACGTGTGGATTGGCTCTGAAGCAATGATTATGCCTGGAGTAAAGGTTGGCCATGGAGCGGTAATTGGCAGCCGGGCTTTGGTTACCAAAGATATAGAGCCATACACAATTGTTGGTGGCAACCCTGCAAAAGAGATAAAGAAGCGCTTTTCAGAACAGGAAATTTCAATGTTGCTAGATATGAAGTGGTGGGATTGGCCGTTGGAGCAAATTAAAGAAGCAATGCCTCTTTTGTGCTCGTCTGATATTGCAGGCTTGTACCATTTTTGGCAGCGTTCAAGTGCCTAA", "partial": "0", "query_start": 1164, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 87.07}, "gnl|BL_ORD_ID|93|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "catB9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "106", "ARO_accession": "3002681", "ARO_name": "catB9", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.82473e-78, "max_identities": 104, "bit_score": 228.024, "cvterm_id": "36789", "query": "NYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVG", "match": "N+F SPF G  L +QV NPNI VG++SYYSGYYHGHSFDDC RYL P+RDDVDKL+IGSFCSIGSGA F+MAGNQGHR DW S+FPFFY Q+   F+ A D F ++G+T+IG+DVWIG+EAM+MPG+KIGHGA+I SRS+VTKDV ", "sequence_from_db": "NFFTSPFSGIPLDQQVTNPNIIVGKHSYYSGYYHGHSFDDCVRYLHPERDDVDKLVIGSFCSIGSGAVFMMAGNQGHRSDWISTFPFFY-QDNDNFADARDGFTRSGDTIIGHDVWIGTEAMIMPGVKIGHGAIIASRSVVTKDVA", "sequence_from_broadstreet": "MNFFTSPFSGIPLDQQVTNPNIIVGKHSYYSGYYHGHSFDDCVRYLHPERDDVDKLVIGSFCSIGSGAVFMMAGNQGHRSDWISTFPFFYQDNDNFADARDGFTRSGDTIIGHDVWIGTEAMIMPGVKIGHGAIIASRSVVTKDVAPYEVVGSNPAKHIKFRFSDVEIAMLLEMAWWNWPESWLKESMQSLCSSDIEGLYLNWQSKART", "dna_sequence_from_broadstreet": "ATGAACTTCTTTACGTCTCCATTTTCTGGGATTCCCTTAGATCAGCAAGTAACAAATCCGAACATTATTGTGGGAAAACACAGTTATTATTCTGGTTATTATCACGGGCACAGTTTCGATGATTGTGTGCGATATTTACATCCAGAAAGAGATGACGTTGATAAGTTAGTCATAGGGAGTTTTTGTTCTATAGGCTCTGGTGCTGTATTTATGATGGCCGGTAATCAAGGGCATCGCAGTGATTGGATAAGTACATTCCCATTTTTCTATCAGGATAATGATAATTTTGCAGATGCACGCGATGGTTTTACGCGTTCAGGAGACACAATTATTGGTCATGATGTGTGGATTGGCACTGAGGCTATGATAATGCCTGGGGTTAAAATTGGACATGGAGCGATAATCGCCAGTCGTTCAGTAGTGACTAAGGATGTTGCACCTTATGAAGTGGTCGGTTCAAATCCTGCTAAACATATCAAGTTTAGATTTTCTGATGTGGAAATAGCGATGTTACTTGAAATGGCATGGTGGAATTGGCCAGAATCGTGGTTGAAAGAGAGTATGCAGTCTCTGTGTTCATCAGACATTGAAGGGCTTTATCTCAATTGGCAGTCAAAAGCACGCACATAA", "partial": "0", "query_start": 1170, "query_end": 1607, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 71.23}, "gnl|BL_ORD_ID|2580|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "Pseudomonas aeruginosa catB7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1042", "ARO_accession": "3002679", "ARO_name": "Pseudomonas aeruginosa catB7", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36521": {"category_aro_accession": "3000382", "category_aro_cvterm_id": "36521", "category_aro_name": "azidamfenicol", "category_aro_description": "Azidamfenicol is a water soluble derivative of chloramphenicol, sharing the same mode of action of inhibiting peptide synthesis by interacting with the 23S RNA of the 50S ribosomal subunit.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36595": {"category_aro_accession": "3000456", "category_aro_cvterm_id": "36595", "category_aro_name": "thiamphenicol", "category_aro_description": "Derivative of Chloramphenicol. The nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3).", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.78045e-77, "max_identities": 117, "bit_score": 226.868, "cvterm_id": "36804", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "M NYF+SPF+GKLLSEQV NPNI+VGRYSYYSGYYHGHSFDDCARYL PDRDDVDKL+IGSFCSIGSGA+FIMAGNQGHR +WAS+FPF +M EEP F+ A++ +Q AG+T+IG+DVWIG+EAM MPG+++GHGA+IGSR+LVT DV     V    A  + +R", "sequence_from_db": "MGNYFESPFRGKLLSEQVSNPNIRVGRYSYYSGYYHGHSFDDCARYLMPDRDDVDKLVIGSFCSIGSGAAFIMAGNQGHRAEWASTFPFHFMHEEPVFAGAVNGYQPAGDTLIGHDVWIGTEAMFMPGVRVGHGAIIGSRALVTGDVEPYAIVGGNPARTIRKR", "sequence_from_broadstreet": "MGNYFESPFRGKLLSEQVSNPNIRVGRYSYYSGYYHGHSFDDCARYLMPDRDDVDKLVIGSFCSIGSGAAFIMAGNQGHRAEWASTFPFHFMHEEPVFAGAVNGYQPAGDTLIGHDVWIGTEAMFMPGVRVGHGAIIGSRALVTGDVEPYAIVGGNPARTIRKRFSDGDIQNLLEMAWWDWPLADIEAAMPLLCTGDIPALYRHWKQRQATA", "dna_sequence_from_broadstreet": "ATGGGCAACTATTTCGAGAGCCCCTTCAGGGGCAAGCTGCTCTCGGAACAGGTCAGCAACCCGAACATACGGGTGGGGCGCTACAGCTACTACTCCGGCTACTATCACGGGCATTCCTTCGACGACTGCGCCCGCTACCTGATGCCGGACCGCGACGACGTGGACAAGCTGGTCATCGGCAGTTTCTGCTCGATCGGCAGTGGCGCCGCCTTCATCATGGCCGGCAACCAGGGACACCGCGCCGAATGGGCGTCGACCTTCCCCTTCCACTTCATGCACGAAGAGCCTGTCTTCGCCGGCGCCGTGAACGGCTATCAGCCAGCCGGCGACACGCTGATCGGCCATGACGTCTGGATCGGTACCGAGGCGATGTTCATGCCCGGCGTACGGGTCGGCCACGGAGCCATCATCGGCAGCCGCGCGCTGGTGACCGGCGATGTCGAGCCCTATGCCATCGTCGGCGGTAACCCGGCCCGGACCATTCGTAAGCGCTTTTCCGATGGCGATATCCAGAACCTGCTGGAAATGGCCTGGTGGGACTGGCCACTGGCCGATATCGAGGCAGCCATGCCACTGCTGTGTACTGGGGATATCCCCGCCTTGTACCGGCACTGGAAACAGCGCCAGGCCACGGCCTGA", "partial": "0", "query_start": 1164, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 71.34}, "gnl|BL_ORD_ID|2572|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "Agrobacterium fabrum chloramphenicol acetyltransferase", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2890", "ARO_accession": "3004451", "ARO_name": "Agrobacterium fabrum chloramphenicol acetyltransferase", "ARO_category": {"36261": {"category_aro_accession": "3000122", "category_aro_cvterm_id": "36261", "category_aro_name": "chloramphenicol acetyltransferase (CAT)", "category_aro_description": "Inactivates chloramphenicol by addition of an acyl group. cat is used to describe many variants of the chloramphenicol acetyltransferase gene in a range of organisms including Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Bacillus clausii, Bacillus subtilis, Campylobacter coli, Enterococcus faecalis, Enterococcus faecium, Lactococcus lactis, Listeria monocytogenes, Listonella anguillarum Morganella morganii, Photobacterium damselae subsp. piscicida, Proteus mirabilis, Salmonella typhi, Serratia marcescens, Shigella flexneri, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus intermedius, Streptococcus agalactiae, Streptococcus suis and Streptomyces acrimycini", "category_aro_class_name": "AMR Gene Family"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.31903e-65, "max_identities": 106, "bit_score": 197.208, "cvterm_id": "36775", "query": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "M NYF+SPF+G  L +QVK+PN+ VG+YSYYSGYYHGHSF+DCARYL PD +  D+L+IGSFCSIGSGA+FIMAGNQGHR +W S+FPFF+M E P F +A + +  AG+TVIGNDVWIGSEA++MPGI +G GAVIG+R+LVTKDV     V    A  + +R", "sequence_from_db": "MENYFESPFRGITLDKQVKSPNLVVGKYSYYSGYYHGHSFEDCARYLLPD-EGADRLVIGSFCSIGSGAAFIMAGNQGHRNEWISTFPFFFMPEVPEFENAANGYLPAGDTVIGNDVWIGSEAIIMPGITVGDGAVIGTRALVTKDVEPYAIVGGNPAKTIRKR", "sequence_from_broadstreet": "MENYFESPFRGITLDKQVKSPNLVVGKYSYYSGYYHGHSFEDCARYLLPDEGADRLVIGSFCSIGSGAAFIMAGNQGHRNEWISTFPFFFMPEVPEFENAANGYLPAGDTVIGNDVWIGSEAIIMPGITVGDGAVIGTRALVTKDVEPYAIVGGNPAKTIRKRFDDDSIALLLEMKWWGWPAERLKAAMPLMTSGNVAALYRFWRSDSL", "dna_sequence_from_broadstreet": "ATGGAAAACTATTTCGAAAGCCCATTCCGGGGCATTACACTCGACAAGCAGGTGAAGAGCCCGAACCTGGTGGTCGGAAAATACAGCTATTATTCCGGCTATTACCACGGCCACAGTTTCGAGGATTGCGCCCGGTACCTGCTGCCCGATGAGGGCGCGGACAGGCTGGTGATCGGAAGCTTCTGCTCGATCGGTTCGGGCGCCGCCTTCATCATGGCGGGCAATCAGGGGCACCGCAACGAATGGATCAGTACCTTCCCGTTCTTCTTCATGCCGGAGGTGCCGGAATTCGAGAATGCCGCCAACGGTTATCTGCCGGCGGGCGACACCGTCATCGGCAACGATGTCTGGATCGGTTCGGAAGCGATCATCATGCCCGGCATCACCGTCGGTGATGGCGCGGTGATCGGAACGCGGGCGCTGGTGACGAAGGACGTCGAGCCCTACGCCATCGTCGGCGGCAACCCCGCAAAAACGATCCGCAAGCGGTTTGACGACGATAGCATCGCCCTGCTGCTCGAGATGAAATGGTGGGGCTGGCCGGCGGAGCGGCTGAAAGCTGCAATGCCGCTGATGACCAGCGGCAATGTCGCGGCGCTCTATCGTTTCTGGCGGTCCGATAGCCTCTAG", "partial": "0", "query_start": 1164, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 64.63}, "gnl|BL_ORD_ID|789|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatH", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "837", "ARO_accession": "3002845", "ARO_name": "vatH", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.28247e-30, "max_identities": 62, "bit_score": 107.457, "cvterm_id": "36779", "query": "KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "+ +   +  PNI VG ++YY    +G  F+D   Y +    D  +LIIG FCSIG G +FIM G   HR D  S++PF  +       +  LD     G+T++GNDVWIG +A +MPG+KIG GA+I ++S+VTKDV     V    A  + +R", "sequence_from_db": "QFVKPSLTRPNIIVGEFTYYDSK-NGELFEDQVLYHYEIIGD--RLIIGKFCSIGPGVTFIMNG-ANHRMD-GSTYPFNIFGHGWEKHTPTLDMLPLKGDTIVGNDVWIGLDATIMPGVKIGDGAIIAAKSVVTKDVDPSTIVGGNPAKQIKKR", "sequence_from_broadstreet": "MAEKLKGPNSNEMYPIAGNKSVQFVKPSLTRPNIIVGEFTYYDSKNGELFEDQVLYHYEIIGDRLIIGKFCSIGPGVTFIMNGANHRMDGSTYPFNIFGHGWEKHTPTLDMLPLKGDTIVGNDVWIGLDATIMPGVKIGDGAIIAAKSVVTKDVDPSTIVGGNPAKQIKKRFSESKIQELLKIKWWDFEDQVISDNIDAILSLDVEALNNISKEND", "dna_sequence_from_broadstreet": "ATGGCAGAAAAATTAAAAGGACCCAACTCAAATGAAATGTATCCGATTGCCGGAAATAAAAGTGTTCAATTTGTTAAACCGTCATTAACAAGGCCCAATATTATAGTTGGTGAGTTCACTTATTATGATAGCAAGAACGGAGAGCTTTTTGAGGATCAAGTTCTGTATCATTATGAAATTATAGGGGATCGACTGATCATCGGGAAATTTTGTTCAATCGGTCCTGGAGTCACTTTTATTATGAATGGAGCTAATCATCGCATGGATGGCTCCACTTATCCATTTAATATCTTTGGGCATGGGTGGGAAAAGCATACACCTACACTAGATATGCTGCCTTTAAAGGGGGATACTATTGTTGGTAATGACGTATGGATTGGACTAGATGCTACAATTATGCCAGGCGTAAAAATAGGAGACGGCGCGATTATTGCAGCCAAATCTGTAGTAACAAAAGACGTTGACCCCTCCACAATTGTTGGTGGTAATCCTGCAAAACAAATAAAGAAACGATTTTCGGAGTCAAAAATTCAAGAACTATTAAAGATAAAATGGTGGGATTTTGAAGACCAGGTTATTAGCGATAATATTGATGCTATTCTAAGTTTGGATGTTGAAGCGCTTAATAATATTTCTAAAGAAAATGATTAG", "partial": "0", "query_start": 1197, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 40.26}, "gnl|BL_ORD_ID|820|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatC", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "872", "ARO_accession": "3002842", "ARO_name": "vatC", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.04845e-30, "max_identities": 61, "bit_score": 106.686, "cvterm_id": "36766", "query": "KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "+ +   +  PNI VG YSYY     G SF+    Y +    D  KLI+G FCSIG G +FIM G   HR D  S+FPF  +       +  L+     GNT IGNDVWIG +  +MPG+KIG+GA+I ++S+VTK+V", "sequence_from_db": "QFIKPSITKPNILVGEYSYYDSK-DGESFESQVLYHYELIGD--KLILGKFCSIGPGTTFIMNG-ANHRMD-GSTFPFNLFGNGWEKHTPTLEDLPYKGNTEIGNDVWIGRDVTIMPGVKIGNGAIIAAKSVVTKNV", "sequence_from_broadstreet": "MKWQNQQGPNPEEIYPIEGNKHVQFIKPSITKPNILVGEYSYYDSKDGESFESQVLYHYELIGDKLILGKFCSIGPGTTFIMNGANHRMDGSTFPFNLFGNGWEKHTPTLEDLPYKGNTEIGNDVWIGRDVTIMPGVKIGNGAIIAAKSVVTKNVDPYSVVGGNPSRLIKIRFSKEKIAALLKVRWWDLEIETINENIDCILNGDIKKVKRS", "dna_sequence_from_broadstreet": "ATGAAATGGCAAAATCAGCAAGGCCCCAATCCAGAAGAAATATACCCTATAGAAGGTAATAAACATGTTCAATTTATTAAACCATCTATAACAAAGCCCAATATTTTAGTTGGGGAATATTCATATTACGATAGTAAAGATGGTGAATCTTTTGAAAGCCAAGTTCTTTATCACTATGAATTGATTGGGGATAAACTAATATTAGGGAAGTTTTGTTCTATTGGACCCGGAACGACATTTATAATGAATGGGGCTAATCATCGTATGGATGGTTCAACATTTCCATTCAATCTTTTCGGAAATGGTTGGGAGAAGCATACCCCTACATTGGAAGACCTTCCTTATAAGGGTAACACGGAAATTGGGAACGATGTTTGGATTGGACGAGATGTGACAATTATGCCCGGTGTAAAAATAGGAAACGGGGCTATTATTGCAGCAAAATCGGTTGTGACAAAGAACGTTGATCCTTATTCAGTTGTTGGCGGTAATCCTTCACGATTAATTAAGATAAGGTTTTCCAAGGAAAAAATCGCAGCATTACTAAAAGTAAGGTGGTGGGACCTAGAGATAGAGACGATAAATGAAAATATTGATTGCATCCTGAATGGTGATATAAAAAAGGTTAAAAGAAGTTAG", "partial": "0", "query_start": 1197, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 44.53}, "gnl|BL_ORD_ID|1120|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatB", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1189", "ARO_accession": "3002841", "ARO_name": "vatB", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.49332e-30, "max_identities": 58, "bit_score": 106.301, "cvterm_id": "35508", "query": "LLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQE--EPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": " +   + NPNI VG Y+YYS       F++   + +  R D  KL+IG FC+I  G  FIM G   HR +  +++PF  M    E A + +L+     G+TV+GNDVWIG    VMPGI+IG GA++ + S+VTKDV", "sequence_from_db": "FIKNTITNPNIIVGDYTYYSDVNGAEKFEEHVTHHYEFRGD--KLVIGKFCAIAEGIEFIMNG-ANHRMNSITTYPFNIMGNGWEKA-TPSLEDLPFKGDTVVGNDVWIGQNVTVMPGIQIGDGAIVAANSVVTKDV", "sequence_from_broadstreet": "MKYGPDPNSIYPHEEIKSVCFIKNTITNPNIIVGDYTYYSDVNGAEKFEEHVTHHYEFRGDKLVIGKFCAIAEGIEFIMNGANHRMNSITTYPFNIMGNGWEKATPSLEDLPFKGDTVVGNDVWIGQNVTVMPGIQIGDGAIVAANSVVTKDVPPYRIIGGNPSRIIKKRFEDELIDYLLQIKWWDWSAQKIFSNLETLCSSDLEKIKSIRD", "dna_sequence_from_broadstreet": "ATGAAATATGGCCCTGATCCAAATAGCATATATCCACATGAAGAAATAAAAAGTGTTTGTTTTATTAAAAATACAATTACCAATCCAAATATTATAGTTGGAGATTATACTTACTATTCCGATGTTAACGGAGCTGAAAAATTTGAAGAACATGTGACACATCATTATGAATTTAGGGGTGATAAACTTGTAATTGGCAAGTTTTGTGCAATAGCTGAAGGTATAGAATTTATTATGAATGGAGCAAACCATAGAATGAATTCAATAACAACTTATCCTTTTAATATAATGGGAAATGGTTGGGAAAAAGCAACTCCATCTCTTGAAGATTTACCATTTAAGGGAGATACTGTTGTTGGAAATGATGTGTGGATTGGTCAGAATGTTACTGTTATGCCAGGAATTCAAATAGGAGATGGAGCAATTGTTGCTGCGAATTCAGTTGTTACAAAAGATGTACCACCATATCGTATTATTGGTGGAAATCCGAGTAGAATTATAAAGAAAAGGTTTGAAGATGAATTGATAGATTATTTATTGCAAATAAAATGGTGGGATTGGTCAGCACAAAAAATATTTTCTAATCTTGAAACACTTTGTAGCTCTGATTTAGAGAAAATAAAATCTATTCGAGATTAG", "partial": "0", "query_start": 1200, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 42.34}, "gnl|BL_ORD_ID|269|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatD", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "290", "ARO_accession": "3002843", "ARO_name": "vatD", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.50114e-29, "max_identities": 59, "bit_score": 103.99, "cvterm_id": "36779", "query": "NIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": "N++VG YSYY    +G +FD    Y +P  +D  KL IG FCSIG G + IM G   HR D  S++PF  +          LD     G+T+IGNDVWIG + ++MPG+KIG GA++ + S+V KD+          A  + QR", "sequence_from_db": "NVEVGEYSYYDSK-NGETFDKQILYHYPILND--KLKIGKFCSIGPGVTIIMNG-ANHRMD-GSTYPFNLFGNGWEKHMPKLDQLPIKGDTIIGNDVWIGKDVVIMPGVKIGDGAIVAANSVVVKDIAPYMLAGGNPANEIKQR", "sequence_from_broadstreet": "MKMYPIEGNKSVQFIKPILEKLENVEVGEYSYYDSKNGETFDKQILYHYPILNDKLKIGKFCSIGPGVTIIMNGANHRMDGSTYPFNLFGNGWEKHMPKLDQLPIKGDTIIGNDVWIGKDVVIMPGVKIGDGAIVAANSVVVKDIAPYMLAGGNPANEIKQRFDQDTINQLLDIKWWNWPIDIINENIDKILDNSIIREVIWKK", "dna_sequence_from_broadstreet": "ATGAAAATGTATCCTATAGAAGGAAACAAATCAGTACAATTTATCAAACCTATTTTAGAAAAATTAGAAAATGTTGAGGTTGGAGAATACTCATATTATGATTCTAAGAATGGAGAAACTTTTGATAAGCAAATTTTATATCATTATCCAATCTTAAACGATAAGTTAAAAATAGGTAAATTTTGCTCAATAGGACCAGGTGTAACTATTATTATGAATGGAGCAAATCATAGAATGGATGGCTCAACATATCCATTTAATTTATTTGGTAATGGATGGGAGAAACATATGCCAAAATTAGATCAACTACCTATTAAGGGGGATACAATAATAGGTAATGATGTATGGATAGGAAAAGATGTTGTAATTATGCCAGGAGTAAAAATCGGGGATGGTGCAATAGTAGCTGCTAATTCTGTTGTTGTAAAAGATATAGCGCCATACATGTTAGCTGGAGGAAATCCTGCTAACGAAATAAAACAAAGATTTGATCAAGATACAATAAATCAGCTGCTTGATATAAAATGGTGGAATTGGCCAATAGACATTATTAATGAGAATATAGATAAAATTCTTGATAATAGCATCATTAGAGAAGTCATATGGAAAAAATGA", "partial": "0", "query_start": 1227, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 40.97}, "gnl|BL_ORD_ID|1635|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1735", "ARO_accession": "3002840", "ARO_name": "vatA", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.74342e-29, "max_identities": 68, "bit_score": 104.375, "cvterm_id": "35508", "query": "PFKG----KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDV--DKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF--FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "P KG    + +   + N NI VG YSYY     G SF+D   Y +    +V  DKLIIG FCSIG G +FIM G   HR D  S++PF  F M  E    S  D   K G+  IGNDVWIG +  +MPG+KIG GA+I + ++VTK+V", "sequence_from_db": "PIKGNRNLQFIKPTITNENILVGEYSYYDSK-RGESFEDQVLYHY----EVIGDKLIIGRFCSIGPGTTFIMNG-ANHRMD-GSTYPFHLFRMGWEKYMPSLKDLPLK-GDIEIGNDVWIGRDVTIMPGVKIGDGAIIAAEAVVTKNV", "sequence_from_broadstreet": "MNLNNDHGPDPENILPIKGNRNLQFIKPTITNENILVGEYSYYDSKRGESFEDQVLYHYEVIGDKLIIGRFCSIGPGTTFIMNGANHRMDGSTYPFHLFRMGWEKYMPSLKDLPLKGDIEIGNDVWIGRDVTIMPGVKIGDGAIIAAEAVVTKNVAPYSIVGGNPLKFIRKRFSDGVIEEWLALQWWNLDMKIINENLPFIINGDIEMLKRKRKLLDDT", "dna_sequence_from_broadstreet": "TTGAATTTAAACAATGACCATGGACCTGATCCCGAAAATATTTTACCGATAAAAGGGAATCGGAATCTTCAATTTATAAAACCTACTATAACGAACGAAAACATTTTGGTGGGGGAATATTCTTATTATGATAGTAAGCGAGGAGAATCCTTTGAAGATCAAGTCTTATATCATTATGAAGTGATTGGAGATAAGTTGATTATAGGAAGATTTTGTTCAATTGGTCCCGGAACAACATTTATTATGAATGGTGCAAACCATCGGATGGATGGATCAACATATCCTTTTCATCTATTCAGGATGGGTTGGGAGAAGTATATGCCTTCCTTAAAAGATCTTCCCTTGAAAGGGGACATTGAAATTGGAAATGATGTATGGATAGGTAGAGATGTAACCATTATGCCTGGGGTGAAAATTGGGGACGGGGCAATCATTGCTGCAGAAGCTGTTGTCACAAAGAATGTTGCTCCCTATTCTATTGTCGGTGGAAATCCCTTAAAATTTATAAGAAAAAGGTTTTCTGATGGAGTTATCGAAGAATGGTTAGCTTTACAATGGTGGAATTTAGATATGAAAATTATTAATGAAAATCTTCCCTTCATAATAAATGGAGATATCGAAATGCTGAAGAGAAAAAGAAAACTTCTAGATGACACTTGA", "partial": "0", "query_start": 1185, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 45.95}, "gnl|BL_ORD_ID|1429|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatE", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1519", "ARO_accession": "3002844", "ARO_name": "vatE", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.62292e-28, "max_identities": 55, "bit_score": 100.523, "cvterm_id": "36779", "query": "VKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQ-EEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVG", "match": "+K+PNI++G Y+YY    +   F+    + +    D  KLIIG FCSI SG  FIM G   H     S++PF  +  +   ++  L      G+TV+GNDVW G    V+PG+KIG GA+IG+ S+VTKDV ", "sequence_from_db": "IKSPNIEIGDYTYYDDPVNPTDFEKHVTHHYEFLGD--KLIIGKFCSIASGIEFIMNG-ANHVMKGISTYPFNILGGDWQQYTPELTDLPLKGDTVVGNDVWFGQNVTVLPGVKIGDGAIIGANSVVTKDVA", "sequence_from_broadstreet": "MTIPDANAIYPNSAIKEVVFIKNVIKSPNIEIGDYTYYDDPVNPTDFEKHVTHHYEFLGDKLIIGKFCSIASGIEFIMNGANHVMKGISTYPFNILGGDWQQYTPELTDLPLKGDTVVGNDVWFGQNVTVLPGVKIGDGAIIGANSVVTKDVAPYTIVGGNPIQLIGPRFEPEVIQALENLAWWNKDIEWITANVPKLMQTTPTLELINSLMEK", "dna_sequence_from_broadstreet": "ATGACTATACCTGACGCAAATGCAATCTATCCTAACTCAGCCATCAAAGAGGTTGTCTTTATCAAGAACGTGATCAAAAGTCCCAATATTGAAATTGGGGACTACACCTATTATGATGACCCAGTAAATCCCACCGATTTTGAGAAACACGTTACCCATCACTATGAATTTCTAGGCGACAAATTAATCATCGGTAAATTTTGTTCTATCGCCAGTGGCATTGAATTTATCATGAACGGTGCCAACCACGTAATGAAAGGTATTTCGACTTATCCATTTAATATTTTAGGTGGCGATTGGCAACAATACACTCCTGAACTGACTGATTTGCCGTTGAAAGGTGATACTGTAGTCGGAAATGACGTGTGGTTTGGGCAAAATGTGACCGTCCTACCAGGCGTAAAAATAGGTGACGGTGCCATTATCGGAGCAAATAGTGTTGTAACAAAAGACGTCGCTCCATATACAATTGTCGGTGGCAATCCAATTCAACTCATCGGACCAAGATTTGAACCGGAAGTTATTCAAGCATTAGAAAATCTGGCATGGTGGAATAAAGATATTGAATGGATAACTGCTAATGTTCCTAAACTAATGCAAACAACACCCACACTTGAATTGATAAACAGTTTAATGGAAAAATAA", "partial": "0", "query_start": 1215, "query_end": 1607, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 41.67}, "gnl|BL_ORD_ID|2102|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "vatF", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2260", "ARO_accession": "3003744", "ARO_name": "vatF", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.21527e-27, "max_identities": 56, "bit_score": 100.523, "cvterm_id": "40164", "query": "LLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQR", "match": " +    +NPNI +G Y+YY       +F+    Y +P   D  KLIIG FC++  G  FIM G   H+    S++PF  +       + + D     G+T +GNDVWIG + ++MPG+ IG+GA+I SRS+VT+DV     V    A  +  R", "sequence_from_db": "FIKNTTQNPNIIIGDYTYYDDPQDSENFERNVLYHYPFIGD--KLIIGKFCALAHGVKFIMNG-ANHKMSGLSTYPFNIFGNGWERVAPSRDELPYKGDTHVGNDVWIGYDVLIMPGVTIGNGAIISSRSVVTRDVPAYSVVGGNPATLIKNR", "sequence_from_broadstreet": "MEDKPILGPDPQCKHPMVGFSQVCFIKNTTQNPNIIIGDYTYYDDPQDSENFERNVLYHYPFIGDKLIIGKFCALAHGVKFIMNGANHKMSGLSTYPFNIFGNGWERVAPSRDELPYKGDTHVGNDVWIGYDVLIMPGVTIGNGAIISSRSVVTRDVPAYSVVGGNPATLIKNRFSAEVIGKLQTIAWWDWPIDAISRNLHLIVAGDIEALARAASEIDHT", "dna_sequence_from_broadstreet": "ATGGAAGATAAGCCAATATTAGGGCCAGATCCCCAGTGTAAACACCCGATGGTGGGGTTTTCTCAAGTATGCTTTATCAAAAATACCACACAGAATCCGAACATTATTATCGGTGATTATACCTACTACGACGATCCACAAGATTCTGAAAACTTTGAACGTAACGTGCTTTATCACTACCCCTTTATTGGTGATAAGCTGATTATCGGCAAATTCTGTGCATTAGCTCATGGGGTGAAGTTCATTATGAATGGTGCCAACCATAAAATGTCTGGGTTATCGACTTACCCATTCAATATTTTTGGTAACGGTTGGGAAAGAGTCGCCCCGTCCAGGGATGAGCTGCCTTATAAAGGCGATACTCATGTCGGAAATGATGTGTGGATTGGCTATGATGTGTTGATTATGCCAGGTGTCACCATTGGCAATGGGGCAATTATTTCATCACGCTCAGTGGTCACGCGCGATGTGCCCGCTTATAGTGTGGTCGGCGGTAATCCCGCAACACTGATTAAAAATCGCTTCTCAGCCGAGGTTATCGGTAAGCTACAAACCATTGCCTGGTGGGATTGGCCAATAGACGCGATCAGTCGCAATCTACACCTGATCGTTGCCGGTGATATCGAGGCATTAGCGCGAGCAGCCAGCGAGATTGATCACACCTAA", "partial": "0", "query_start": 1200, "query_end": 1655, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 36.6}, "gnl|BL_ORD_ID|2299|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "VatI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "2523", "ARO_accession": "3003987", "ARO_name": "VatI", "ARO_category": {"36592": {"category_aro_accession": "3000453", "category_aro_cvterm_id": "36592", "category_aro_name": "streptogramin vat acetyltransferase", "category_aro_description": "vat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.", "category_aro_class_name": "AMR Gene Family"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.24117e-27, "max_identities": 57, "bit_score": 97.8265, "cvterm_id": "40862", "query": "KLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPF-FYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDV", "match": "+ +   +  PNI  G YSYY    +G SF+D   Y +       KL+IG FCSI S   F+M G   HR D  S+FPF  +      F+ +LD     G+T+IGNDVWIG  A +M G++IG GA+I + ++V KDV", "sequence_from_db": "QFIKNTITKPNIIAGDYSYYYAL-NGESFEDQVLYHYEFIGT--KLMIGKFCSIASEVRFMMDGGN-HRMD-GSTFPFNIFGNGWEKFTPSLDQLPIKGDTIIGNDVWIGRRATIMSGVRIGDGAIIAAEAVVVKDV", "sequence_from_broadstreet": "MTGPNPNERYPIPGDNNLQFIKNTITKPNIIAGDYSYYYALNGESFEDQVLYHYEFIGTKLMIGKFCSIASEVRFMMDGGNHRMDGSTFPFNIFGNGWEKFTPSLDQLPIKGDTIIGNDVWIGRRATIMSGVRIGDGAIIAAEAVVVKDVEPYTIVGGNPAKDIRKRYSTEVIQELLDIKWWDCDIEVINQYIGAIVSGDMDLLRKMRQN", "dna_sequence_from_broadstreet": "ATGACAGGACCGAATCCAAATGAGAGATATCCTATACCCGGAGATAACAATCTTCAGTTTATCAAGAACACGATTACAAAACCTAATATTATCGCAGGGGATTATTCATACTACTATGCCTTAAACGGAGAATCATTTGAGGATCAAGTATTGTATCATTATGAATTCATTGGAACTAAATTAATGATCGGCAAGTTTTGTTCCATTGCTTCCGAGGTCAGATTTATGATGGATGGAGGGAACCATCGGATGGACGGTTCAACCTTTCCATTTAATATCTTTGGAAACGGCTGGGAGAAATTCACTCCATCTTTGGATCAATTGCCGATCAAGGGAGATACGATCATTGGAAATGACGTGTGGATCGGAAGGCGTGCAACGATCATGTCGGGTGTAAGGATTGGCGATGGAGCTATCATTGCCGCTGAAGCTGTCGTTGTAAAGGATGTGGAGCCTTATACGATCGTTGGAGGCAATCCAGCGAAGGATATCCGCAAGCGATATTCCACCGAAGTCATTCAAGAGTTATTGGATATTAAATGGTGGGATTGCGATATCGAAGTCATCAATCAATATATTGGCGCAATTGTAAGCGGAGATATGGACTTGCTTAGAAAAATGAGACAAAATTAG", "partial": "0", "query_start": 1197, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 41.61}, "gnl|BL_ORD_ID|2226|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1164, "orf_end": 1712, "orf_from": "NODE_51_length_1731_cov_22.5767_2 ", "model_name": "apmA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "model_id": "2395", "ARO_accession": "3003918", "ARO_name": "apmA", "ARO_category": {"41422": {"category_aro_accession": "3004258", "category_aro_cvterm_id": "41422", "category_aro_name": "amp acetyltransferase", "category_aro_description": "A family of acetyltransferases that confer resistance to apramycin.", "category_aro_class_name": "AMR Gene Family"}, "35955": {"category_aro_accession": "0000037", "category_aro_cvterm_id": "35955", "category_aro_name": "apramycin", "category_aro_description": "Apramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections in animals. Apramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.00481428, "max_identities": 33, "bit_score": 33.113, "cvterm_id": "35508", "query": "IGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPA-FSSALD-------AFQKAGNTVIGNDVWIGSEAMVMPGI--KIGHGAVIGSRSLVTKDV", "match": "IG F SI +G + I A +Q +    +     F+ +E  A F   L        A+ K   T IG+DV+IG+ A +       IG GA+IGS ++V ++V", "sequence_from_db": "IGQFTSI-NGTAEIHANHQLNMTFVSDDIQNFFNEESMAVFQEKLRKDPKHPYAYSKEPMT-IGSDVYIGAHAFINASTVTSIGDGAIIGSGAVVLENV", "sequence_from_broadstreet": "MKTRLEQVLERYLNGREVAVWGVPTRRLLRALKPFKFHTADRVDPQYHYVVAVTDDDLTDFLSDEQSKSFQYANDYLTFDDEGGELPFERMCFNVPVGRQTYFGDGVVGACENGYIKSIGQFTSINGTAEIHANHQLNMTFVSDDIQNFFNEESMAVFQEKLRKDPKHPYAYSKEPMTIGSDVYIGAHAFINASTVTSIGDGAIIGSGAVVLENVPPFAVVVGVPARIKRYRFSKEMIETLLRVKWWDWSIEEINENVDALISPELFMKKYGSL", "dna_sequence_from_broadstreet": "ATGAAAACCAGACTTGAACAAGTTTTAGAACGTTATCTCAACGGACGCGAGGTAGCTGTATGGGGTGTTCCGACACGCCGTTTGCTTCGTGCATTAAAACCTTTTAAATTTCATACTGCCGATCGTGTTGATCCTCAATATCATTATGTTGTTGCTGTAACCGATGACGACTTAACCGACTTTTTATCCGATGAACAGAGCAAGTCGTTTCAATACGCGAATGACTACCTTACGTTTGACGACGAGGGAGGCGAACTTCCGTTTGAACGAATGTGCTTCAATGTCCCCGTTGGCAGGCAAACGTATTTTGGAGACGGTGTCGTAGGAGCTTGCGAAAACGGGTATATCAAGAGCATCGGCCAATTTACATCGATTAACGGCACGGCAGAGATCCATGCGAACCATCAGTTAAACATGACCTTTGTAAGCGACGATATTCAAAACTTCTTCAACGAAGAAAGCATGGCTGTATTCCAAGAAAAGCTGCGAAAAGACCCGAAACACCCTTATGCTTATAGCAAAGAACCTATGACCATAGGTAGCGATGTTTATATCGGCGCACATGCATTCATCAATGCTTCCACTGTGACAAGCATCGGTGACGGTGCAATAATTGGCTCAGGGGCAGTAGTTCTGGAAAATGTTCCTCCTTTTGCTGTCGTCGTTGGTGTCCCTGCGAGAATCAAGCGTTACCGCTTCTCAAAGGAGATGATTGAAACCCTCCTTCGTGTCAAATGGTGGGACTGGAGTATAGAGGAAATTAACGAAAATGTTGATGCGCTTATATCACCTGAACTATTTATGAAAAAGTACGGGAGTTTGTAA", "partial": "0", "query_start": 1338, "query_end": 1604, "orf_dna_sequence": "ATGACCAACTACTTTGATAGCCCCTTCAAAGGCAAGCTGCTTTCTGAGCAAGTGAAGAACCCCAATATCAAAGTTGGGCGGTACAGCTATTACTCTGGCTACTATCATGGGCACTCATTCGATGACTGCGCACGGTATCTGTTTCCGGACCGTGATGACGTTGATAAGTTGATCATCGGTAGTTTCTGCTCTATCGGGAGTGGGGCTTCCTTTATCATGGCTGGCAATCAGGGGCATCGGTACGACTGGGCATCATCTTTCCCGTTCTTTTATATGCAGGAAGAACCTGCATTCTCAAGCGCACTCGATGCCTTCCAAAAAGCAGGTAATACTGTCATTGGCAATGACGTTTGGATCGGCTCTGAGGCAATGGTCATGCCCGGAATCAAGATCGGGCACGGTGCGGTGATAGGCAGCCGCTCGTTGGTGACAAAAGATGTGGGGCACTGTTGCAAAGTTAGCGATGAGGCAGCCTTTTGTCTTATTCAAAGGCCTTACATTTCAAAAACTCTGCTTACCAGGCGCATTTCGCCCAGGGGATCACCATAA", "orf_prot_sequence": "MTNYFDSPFKGKLLSEQVKNPNIKVGRYSYYSGYYHGHSFDDCARYLFPDRDDVDKLIIGSFCSIGSGASFIMAGNQGHRYDWASSFPFFYMQEEPAFSSALDAFQKAGNTVIGNDVWIGSEAMVMPGIKIGHGAVIGSRSLVTKDVGHCCKVSDEAAFCLIQRPYISKTLLTRRISPRGSP", "perc_identity": 33.33}}, "NODE_54_length_1272_cov_25.1921_2 # 1130 # 1270 # 1 # ID=54_2;partial=01;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.496": {"gnl|BL_ORD_ID|1582|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib-cr", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1678", "ARO_accession": "3002547", "ARO_name": "AAC(6')-Ib-cr", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.5007e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "35914", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|937|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "993", "ARO_accession": "3002580", "ARO_name": "AAC(6')-Ib9", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.69358e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "36752", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1285|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1370", "ARO_accession": "3002581", "ARO_name": "AAC(6')-Ib10", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.71194e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "36752", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1960|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "475", "model_id": "2117", "ARO_accession": "3002578", "ARO_name": "AAC(6')-Ib7", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.30278e-26, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "35906", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MRSRNWSRTLTERSGGNGAVAVFMACYDCFFVQSMPRASKQQARYAVGRCLMLWSSNDVTQQGSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGCGCTCACGCAACTGGTCCAGAACCTTGACCGAACGCAGCGGTGGTAACGGCGCAGTGGCGGTTTTCATGGCTTGTTATGACTGTTTTTTTGTACAGTCTATGCCTCGGGCATCCAAGCAGCAAGCGCGTTACGCCGTGGGTCGATGTTTGATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1950|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2071", "ARO_accession": "3002579", "ARO_name": "AAC(6')-Ib8", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.95946e-26, "max_identities": 41, "bit_score": 90.1225, "cvterm_id": "36884", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNS DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSLKPGPKRIAESTGQPDQRQRDNKKTPGNTDKLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCCTTAAACCCGGACCAAAAAGAATTGCCGAATCGACGGGGCAACCTGATCAACGCCAACGCGACAATAAAAAGACGCCTGGAAATACTGACAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 93.18}, "gnl|BL_ORD_ID|1702|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1801", "ARO_accession": "3002582", "ARO_name": "AAC(6')-Ib11", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.37107e-26, "max_identities": 43, "bit_score": 89.3521, "cvterm_id": "35732", "query": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MKNTIH    NSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MKNTIH---INSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MKNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCTGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1130, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 91.49}, "gnl|BL_ORD_ID|865|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "922", "ARO_accession": "3002599", "ARO_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.02077e-25, "max_identities": 42, "bit_score": 90.5077, "cvterm_id": "36752", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTFLIRPVEQSDAESWERLRNLLWEGDDHKSEITQFFNGEVEEPNEVLLAVTEENDAIAHIELSLRYDIDGLTGIKTGYIEGLFVEERHRAAGVVLKLLRAAEFWARDQGCLAFASDRDDRVIIYARYTGAPPNNSLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "ATGACATTCCTGATCCGACCCGTAGAACAAAGTGACGCTGAATCTTGGGAGCGCTTACGCAACCTTTTGTGGGAGGGCGACGACCACAAAAGCGAGATCACACAATTCTTCAACGGCGAAGTAGAAGAACCCAATGAAGTGTTGCTTGCCGTAACCGAAGAAAATGATGCAATAGCGCACATCGAGCTATCGTTGAGGTATGACATTGATGGCTTGACGGGCATCAAGACCGGTTACATCGAAGGCCTTTTTGTAGAGGAGCGGCACCGTGCCGCAGGTGTAGTCCTCAAGCTATTGCGAGCCGCAGAGTTCTGGGCAAGAGATCAAGGATGTCTGGCGTTTGCCTCAGACAGGGATGATCGTGTCATCATCTATGCTCGCTACACGGGAGCGCCACCTAACAATTCATTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2046|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "339", "ARO_accession": "3002598", "ARO_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "41439": {"category_aro_accession": "3004275", "category_aro_cvterm_id": "41439", "category_aro_name": "ANT(3'')", "category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.35403e-25, "max_identities": 42, "bit_score": 91.2781, "cvterm_id": "36783", "query": "TIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "T +SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "TKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAVPAEISVQLSLALNAIERHLESTLLAVHLYGSALDGGLKPYSDIDLLVTVAAQLDETVRQALVVDLLEISASPGQSEALRALEVTIVVHGDVVPWRYPARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKVRQHSLALAGSAAEDFFNPVPEGDLFKALSDTLKLWNSQPDWEGDERNVVLTLSRIWYSAATGKIAPKDIVANWAIERLPDQHKPVLLEARQAYLGRGEDCLASRADQLAAFVHFVKHEATKLLGAMPVMSKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGTAACGCAGTACCCGCCGAGATTTCGGTACAGCTATCACTGGCTCTCAACGCCATCGAGCGTCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTGGACGGTGGCCTGAAGCCATACAGTGATATTGATTTGCTGGTTACTGTGGCTGCACAGCTCGATGAGACTGTCCGACAAGCCCTGGTCGTAGATCTCTTGGAAATTTCTGCCTCCCCTGGCCAAAGTGAGGCTCTCCGCGCCTTGGAAGTTACCATCGTCGTGCATGGTGATGTTGTCCCTTGGCGTTATCCGGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGTAAAGACATTCTTGCGGGCATCTTCGAGCCCGCCACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGTAAGGCAGCATAGCCTTGCATTGGCAGGTTCGGCCGCAGAGGATTTCTTTAACCCAGTTCCGGAAGGCGATCTATTCAAGGCATTGAGCGACACTCTGAAACTATGGAATTCGCAGCCGGATTGGGAAGGCGATGAGCGGAATGTAGTGCTTACCTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCACCGAAGGATATCGTTGCCAACTGGGCAATTGAGCGTCTGCCAGATCAACATAAGCCCGTACTGCTTGAAGCCCGGCAGGCTTATCTTGGACGAGGAGAAGATTGCTTGGCCTCACGCGCGGATCAGTTGGCGGCGTTCGTTCACTTCGTGAAACATGAAGCCACTAAATTGCTTGGTGCCATGCCAGTGATGTCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1139, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 95.45, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1162|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib'", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1235", "ARO_accession": "3003676", "ARO_name": "AAC(6')-Ib'", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.93886e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|194|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(3)-Ib/AAC(6')-Ib''", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "209", "ARO_accession": "3002600", "ARO_name": "AAC(3)-Ib/AAC(6')-Ib''", "ARO_category": {"36461": {"category_aro_accession": "3000322", "category_aro_cvterm_id": "36461", "category_aro_name": "AAC(3)", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 3.", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.12027e-24, "max_identities": 37, "bit_score": 87.0409, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEW+NRSHIVEWWGGEEA", "sequence_from_db": "LTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSIIATVKIGPDEISAMRAVLDLFGKEFEDIPTYSDRQPTNEYLANLLHSETFIALAAFDRGTAIGGLAAYVLPKFEQARSEIYIYDLAVASSHRRLGVATALISHLKRVAVELGAYVIYVQADYGDDPAVALYTKLGVREDVMHFDIDPLTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGGGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCATCATTGCAACCGTCAAGATCGGCCCTGACGAAATTTCAGCCATGAGGGCTGTGCTCGATCTCTTCGGCAAAGAGTTTGAGGACATTCCAACCTACTCTGATCGCCAGCCGACCAATGAGTATCTTGCCAATCTTCTGCACAGCGAGACGTTCATCGCGCTCGCTGCTTTTGACCGCGGAACAGCAATAGGTGGGCTCGCAGCCTACGTTCTACCCAAGTTCGAGCAAGCGCGAAGCGAGATCTACATTTATGACTTGGCAGTCGCTTCCAGCCATCGAAGGCTAGGAGTCGCAACTGCCCTGATTAGCCACCTGAAGCGTGTGGCGGTTGAACTTGGCGCGTATGTAATCTATGTGCAAGCAGACTACGGTGACGATCCGGCAGTCGCTCTCTACACAAAGCTTGGAGTTCGGGAAGACGTCATGCACTTCGACATTGATCCATTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGGTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAGGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 94.87}, "gnl|BL_ORD_ID|53|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "63", "ARO_accession": "3002546", "ARO_name": "AAC(6')-Ib", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.13431e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "35915", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTAACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAAGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|945|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1002", "ARO_accession": "3002577", "ARO_name": "AAC(6')-Ib4", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.40495e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1001|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1068", "ARO_accession": "3002576", "ARO_name": "AAC(6')-Ib3", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.7601e-24, "max_identities": 38, "bit_score": 84.3445, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATTGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|411|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib-Suzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "444", "ARO_accession": "3002591", "ARO_name": "AAC(6')-Ib-Suzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.51337e-16, "max_identities": 27, "bit_score": 64.3142, "cvterm_id": "36884", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCATGGATGCCTAA", "partial": "0", "query_start": 1190, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|944|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ib-Hangzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1000", "ARO_accession": "3002592", "ARO_name": "AAC(6')-Ib-Hangzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.06367e-15, "max_identities": 26, "bit_score": 62.7734, "cvterm_id": "35507", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDL MLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLVMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGTGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 1190, "query_end": 1270, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.3, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1481|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1577", "ARO_accession": "3002586", "ARO_name": "AAC(6')-32", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.64612e-15, "max_identities": 27, "bit_score": 61.2326, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   VTLRLMTE DL ML+ WLNR HIVEWWGGEE", "sequence_from_db": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "dna_sequence_from_broadstreet": "ATGTCCCCGAGCAAAACACCCGTTACCTTGCGCCTCATGACCGAGCGCGACCTACCGATGCTGCATGCATGGCTGAACCGGCCGCACATTGTCGAGTGGTGGGGTGGAGAAGAAGAACGCCCGACTCTTCATGAAGTGGTCAAACACTACCTGCCGAGGGTTTTGGCAGAAGAAGCCGTCACACCATACATCGCGATGTTGGGCGACGAACCCATCGGCTACGCTCAGTCATACGTCGCACTCGGAAGCGGTGATGGATGGTGGGAGGATGAAACCGACCCAGGCGTACGAGGGATAGACCAATTCCTGTCGAACCATACACAGTTGAACCAGGGCCTAGGTACAAAGCTCGTCCAGGCACTCGTTGAACTGCTGTTCTCAGATCCTACCGTGACGAAGATCCAAACCGACCCGGCGCCAAACAACCATCGAGCGATTCGCTGCTACGAGAAAGCTGGCTTTGTTCAGCAAAACGTCATCACCACACCAGACGGCCCAGCCGTCTACATGGTTCAAACCAGGCAGGCCTTCGAGCGTGTGCGCAGTGCTGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 71.05}, "gnl|BL_ORD_ID|1563|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-IIa", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1657", "ARO_accession": "3002594", "ARO_name": "AAC(6')-IIa", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.73463e-15, "max_identities": 25, "bit_score": 60.8474, "cvterm_id": "35731", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   +TLRLMTE DL ML++WLNR HIVEWWGG+E", "sequence_from_db": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDE", "sequence_from_broadstreet": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "dna_sequence_from_broadstreet": "ATGTCCGCGAGCACCCCCCCCATAACTCTTCGCCTCATGACCGAGCGCGACCTGCCGATGCTCCATGATTGGCTCAACCGGCCGCACATCGTTGAGTGGTGGGGTGGTGACGAAGAGCGACCGACTCTTGATGAAGTGCTGGAACACTACCTGCCCAGAGCGATGGCGGAAGAGTCCGTAACACCGTACATCGCAATGCTGGGCGAGGAACCGATCGGCTATGCTCAGTCGTACGTCGCGCTCGGAAGCGGTGATGGCTGGTGGGAAGATGAAACTGATCCAGGAGTGCGAGGAATAGACCAGTCTCTGGCTGACCCGACACAGTTGAACAAAGGCCTAGGAACAAGGCTTGTCCGCGCTCTCGTTGAACTACTGTTCTCGGACCCCACCGTGACGAAGATTCAGACCGACCCGACTCCGAACAACCATCGAGCCATACGCTGCTATGAGAAGGCAGGATTCGTGCGGGAGAAGATCATCACCACGCCTGACGGGCCGGCGGTTTACATGGTTCAAACACGACAAGCCTTCGAGAGAAAGCGCGGTGTTGCCTAA", "partial": "0", "query_start": 1154, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 65.79}, "gnl|BL_ORD_ID|125|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-IIb", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "140", "ARO_accession": "3002595", "ARO_name": "AAC(6')-IIb", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.683e-14, "max_identities": 24, "bit_score": 58.9214, "cvterm_id": "36937", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGE", "match": "VTLR MTE D+ ML+EWLNR HIVEWWGGE", "sequence_from_db": "VTLRPMTEDDIGMLHEWLNRPHIVEWWGGE", "sequence_from_broadstreet": "MHPGVVTLRPMTEDDIGMLHEWLNRPHIVEWWGGERPSLEEVKEDYRPSALAEEGVTPYIGLLDGTPFAFAQSYVALGSGGGWWEEETDPGVRGIDQSIADSGLLGRGYGTRLVQALVDLLFADPQVSKVQTDPSPNNMRAIRCYEKAGFRKVKVVSTPDGPAMYMLHERPLVNGLRSAA", "dna_sequence_from_broadstreet": "ATGCATCCCGGCGTTGTTACTCTGCGTCCGATGACCGAAGACGACATCGGTATGCTTCACGAATGGTTGAATCGGCCGCACATTGTCGAATGGTGGGGTGGTGAGCGGCCCTCGCTCGAAGAGGTGAAAGAGGACTATCGGCCCAGCGCGTTGGCCGAAGAAGGAGTGACGCCGTACATCGGTTTGCTTGACGGAACTCCATTCGCGTTCGCACAGTCGTACGTTGCGCTCGGGTCGGGTGGTGGATGGTGGGAGGAAGAGACCGATCCTGGTGTCCGCGGAATCGATCAATCAATCGCCGATTCCGGGCTTCTCGGAAGAGGTTACGGCACTCGGCTGGTGCAGGCGCTTGTTGATTTGCTGTTCGCCGACCCGCAGGTATCCAAGGTTCAGACGGACCCCTCCCCGAACAACATGCGCGCGATACGCTGCTATGAGAAGGCAGGCTTCCGGAAGGTCAAGGTCGTTTCAACACCGGATGGGCCGGCCATGTACATGTTGCACGAGCGTCCGTTGGTGAACGGTTTGCGCAGTGCGGCCTAA", "partial": "0", "query_start": 1175, "query_end": 1264, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 80.0}, "gnl|BL_ORD_ID|1024|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "325", "model_id": "1093", "ARO_accession": "3002585", "ARO_name": "AAC(6')-31", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.8099e-13, "max_identities": 22, "bit_score": 56.6102, "cvterm_id": "36803", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "MTEHDL ML++WLNR HIVEWWGGEE", "sequence_from_db": "MTEHDLPMLHDWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MTEHDLPMLHDWLNRPHIVEWWGGEETRPTLAEVLEQYLPSALAKESVTPYIAMLDEEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLGKGLGTKLVCALVEMLFKDAEVTKIQTDPSPNNLRAIRCYEKAGFVAQRTINTPDGPAVYMVQTRQAFEQARSAV", "dna_sequence_from_broadstreet": "ATGACCGAGCACGACCTTCCGATGCTCCATGACTGGCTAAATCGGCCTCACATCGTTGAGTGGTGGGGCGGAGAAGAAACACGTCCAACACTTGCTGAAGTGCTGGAGCAATACCTACCAAGCGCCCTGGCGAAAGAGTCCGTCACTCCCTACATCGCAATGCTGGATGAAGAACCGATTGGGTACGCTCAGTCGTACATTGCACTCGGAAGCGGTGACGGATGGTGGGAAGACGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCTCTGGCGAATCCATCGCAGCTGGGCAAGGGCTTGGGAACCAAGCTCGTTTGCGCGCTCGTTGAGATGCTGTTCAAAGACGCTGAGGTAACCAAGATCCAAACGGACCCGTCGCCGAACAACTTACGCGCAATCCGGTGCTACGAGAAGGCGGGTTTTGTGGCGCAAAGAACCATAAACACCCCAGATGGACCGGCCGTATACATGGTTCAAACACGTCAGGCGTTCGAGCAGGCGCGCAGTGCTGTCTAA", "partial": "0", "query_start": 1190, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 84.62}, "gnl|BL_ORD_ID|687|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-IIc", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "730", "ARO_accession": "3002596", "ARO_name": "AAC(6')-IIc", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.33726e-13, "max_identities": 22, "bit_score": 56.225, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ +N ++ LR+M E+DL ML+ WLNR HIVEWWGGE+", "sequence_from_db": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGED", "sequence_from_broadstreet": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRTVQSFKIKGKWS", "dna_sequence_from_broadstreet": "ATGTCCGCCAACAATGCCGCAATAGTTCTACGAGTCATGGCCGAGAACGATCTGCCAATGCTCCATGCTTGGCTGAACCGCCCCCACATAGTCGAGTGGTGGGGCGGCGAGGATGAACGCCCAACTCTTGACGAAGTCTTAGAACACTATTCGCCCGAAGTTCTGGCAAAGCAAGCTGTAGTGCCTTACATCGCAATGCTAGATGACGAACCCATCGGCTACGCCCAATCCTACATCGCACTTGGAAGTGGCGATGGATGGTGGGAAGACGAAACTGATCCAGGGGTCCGCGGGATTGACCAGTCTTTGGCTAATCCATCACAGTTAAACAAGGGGTTGGGTACAAAGCTCGTACGCTCGCTCGTTGAACTCCTGTTTAGCGACCCGGCCGTAACGAAAATCCAAACCGATCCATCTCCTAGCAACCATCGCGCCATTCGCTGCTACGAGAAGGCCGGGTTCGTTCAAGAAAAAAACATCCTCACACCTGACGGCCCTGCGGTGTACATGGTCCAAACACGCCAGGCGTTCGAAAGCCTGCGCACTGTTCAAAGCTTCAAAATCAAGGGGAAGTGGTCATGA", "partial": "0", "query_start": 1154, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 57.89}, "gnl|BL_ORD_ID|1714|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-Ie-APH(2'')-Ia", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "1814", "ARO_accession": "3002597", "ARO_name": "AAC(6')-Ie-APH(2'')-Ia", "ARO_category": {"36267": {"category_aro_accession": "3000128", "category_aro_cvterm_id": "36267", "category_aro_name": "APH(2'')", "category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0252516, "max_identities": 7, "bit_score": 26.9498, "cvterm_id": "35508", "query": "DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+ + +R + + D  ++ +WL    ++E++GG +", "sequence_from_db": "NEICIRTLIDDDFPLMLKWLTDERVLEFYGGRD", "sequence_from_broadstreet": "MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD", "dna_sequence_from_broadstreet": "ATGAATATAGTTGAAAATGAAATATGTATAAGAACTTTAATAGATGATGATTTTCCTTTGATGTTAAAATGGTTAACTGATGAAAGAGTATTAGAATTTTATGGTGGTAGAGATAAAAAATATACATTAGAATCATTAAAAAAACATTATACAGAGCCTTGGGAAGATGAAGTTTTTAGAGTAATTATTGAATATAACAATGTTCCTATTGGATATGGACAAATATATAAAATGTATGATGAGTTATATACTGATTATCATTATCCAAAAACTGATGAGATAGTCTATGGTATGGATCAATTTATAGGAGAGCCAAATTATTGGAGTAAAGGAATTGGTACAAGATATATTAAATTGATTTTTGAATTTTTGAAAAAAGAAAGAAATGCTAATGCAGTTATTTTAGACCCTCATAAAAATAATCCAAGAGCAATAAGGGCATACCAAAAATCTGGTTTTAGAATTATTGAAGATTTGCCAGAACATGAATTACACGAGGGCAAAAAAGAAGATTGTTATTTAATGGAATATAGATATGATGATAATGCCACAAATGTTAAGGCAATGAAATATTTAATTGAGCATTACTTTGATAATTTCAAAGTAGATAGTATTGAAATAATCGGTAGTGGTTATGATAGTGTGGCATATTTAGTTAATAATGAATACATTTTTAAAACAAAATTTAGTACTAATAAGAAAAAAGGTTATGCAAAAGAAAAAGCAATATATAATTTTTTAAATACAAATTTAGAAACTAATGTAAAAATTCCTAATATTGAATATTCGTATATTAGTGATGAATTATCTATACTAGGTTATAAAGAAATTAAAGGAACTTTTTTAACACCAGAAATTTATTCTACTATGTCAGAAGAAGAACAAAATTTGTTAAAACGAGATATTGCCAGTTTTTTAAGACAAATGCACGGTTTAGATTATACAGATATTAGTGAATGTACTATTGATAATAAACAAAATGTATTAGAAGAGTATATATTGTTGCGTGAAACTATTTATAATGATTTAACTGATATAGAAAAAGATTATATAGAAAGTTTTATGGAAAGACTAAATGCAACAACAGTTTTTGAGGGTAAAAAGTGTTTATGCCATAATGATTTTAGTTGTAATCATCTATTGTTAGATGGCAATAATAGATTAACTGGAATAATTGATTTTGGAGATTCTGGAATTATAGATGAATATTGTGATTTTATATACTTACTTGAAGATAGTGAAGAAGAAATAGGAACAAATTTTGGAGAAGATATATTAAGAATGTATGGAAATATAGATATTGAGAAAGCAAAAGAATATCAAGATATAGTTGAAGAATATTATCCTATTGAAACTATTGTTTATGGAATTAAAAATATTAAACAGGAATTTATCGAAAATGGTAGAAAAGAAATTTATAAAAGGACTTATAAAGATTGA", "partial": "0", "query_start": 1169, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 21.21}, "gnl|BL_ORD_ID|1698|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "ErmY", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1797", "ARO_accession": "3002825", "ARO_name": "ErmY", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.430364, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "35508", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALLLMTEVDISIL", "sequence_from_broadstreet": "MNKKDIKFSQNFITSKRHINKIMSNLELNRNDNVFEIGSGKGHFTLELVQKCNYVTVIEIDSNLCIQTQNKVTNYDNFRIINKDILQFKFPNNKAYKIYGNIPYYISTDIVRKIVFESEATVSYLIVEEGFAKRLLNTNRSLALLLMTEVDISILSKIPKEYFHPKPKINSSLIILKRHPSKISYKDKKMYNNFVMKWVNQEYSKLFTKNQFNKALNYAKIKDLKNINFEQFLSVFNSYKLFNN", "dna_sequence_from_broadstreet": "ATGAACAAAAAAGATATAAAATTTAGTCAAAATTTTATTACTTCGAAACGACATATAAATAAAATAATGAGTAATTTAGAATTAAATAGAAATGATAATGTTTTTGAAATTGGTTCAGGAAAAGGGCATTTCACACTAGAACTGGTTCAAAAATGTAATTATGTAACAGTTATCGAGATAGATTCAAATTTATGTATTCAAACACAAAATAAAGTTACAAATTACGATAACTTTCGAATTATAAATAAGGATATATTACAGTTTAAGTTCCCAAACAACAAAGCATATAAAATCTACGGTAATATACCTTATTATATAAGTACGGATATAGTACGAAAAATTGTCTTTGAAAGTGAAGCAACAGTTAGTTACTTAATAGTTGAAGAAGGATTTGCTAAAAGGCTACTCAATACAAATCGTTCTCTAGCGTTACTTTTAATGACTGAAGTAGATATATCCATATTAAGTAAAATCCCTAAAGAATACTTTCATCCAAAGCCTAAAATTAATAGCTCTTTAATTATATTAAAAAGACACCCGTCAAAAATATCATACAAAGATAAAAAAATGTATAATAATTTTGTTATGAAATGGGTTAACCAAGAATACAGCAAACTATTTACCAAAAATCAGTTTAATAAAGCCTTAAATTATGCAAAAATAAAGGATTTAAAGAACATTAACTTCGAACAATTTTTATCAGTATTTAATAGCTATAAATTGTTTAATAACTAA", "partial": "0", "query_start": 1160, "query_end": 1216, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|1199|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "ErmT", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1275", "ARO_accession": "3000595", "ARO_name": "ErmT", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35946": {"category_aro_accession": "0000027", "category_aro_cvterm_id": "35946", "category_aro_name": "roxithromycin", "category_aro_description": "Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35964": {"category_aro_accession": "0000046", "category_aro_cvterm_id": "35964", "category_aro_name": "lincomycin", "category_aro_description": "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction.", "category_aro_class_name": "Antibiotic"}, "35974": {"category_aro_accession": "0000057", "category_aro_cvterm_id": "35974", "category_aro_name": "telithromycin", "category_aro_description": "Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35982": {"category_aro_accession": "0000065", "category_aro_cvterm_id": "35982", "category_aro_name": "clarithromycin", "category_aro_description": "Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections.", "category_aro_class_name": "Antibiotic"}, "35983": {"category_aro_accession": "0000066", "category_aro_cvterm_id": "35983", "category_aro_name": "clindamycin", "category_aro_description": "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria.", "category_aro_class_name": "Antibiotic"}, "36284": {"category_aro_accession": "3000145", "category_aro_cvterm_id": "36284", "category_aro_name": "tylosin", "category_aro_description": "Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36295": {"category_aro_accession": "3000156", "category_aro_cvterm_id": "36295", "category_aro_name": "spiramycin", "category_aro_description": "Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36315": {"category_aro_accession": "3000176", "category_aro_cvterm_id": "36315", "category_aro_name": "dirithromycin", "category_aro_description": "Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36722": {"category_aro_accession": "3000583", "category_aro_cvterm_id": "36722", "category_aro_name": "pristinamycin IA", "category_aro_description": "Pristinamycin 1A is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains.", "category_aro_class_name": "Antibiotic"}, "36723": {"category_aro_accession": "3000584", "category_aro_cvterm_id": "36723", "category_aro_name": "quinupristin", "category_aro_description": "Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "37019": {"category_aro_accession": "3000675", "category_aro_cvterm_id": "37019", "category_aro_name": "pristinamycin IB", "category_aro_description": "Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group).", "category_aro_class_name": "Antibiotic"}, "37021": {"category_aro_accession": "3000677", "category_aro_cvterm_id": "37021", "category_aro_name": "virginiamycin S2", "category_aro_description": "Virginiamycin S2 is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37022": {"category_aro_accession": "3000678", "category_aro_cvterm_id": "37022", "category_aro_name": "vernamycin B-gamma", "category_aro_description": "Vernamycin B-gamma is a class B streptogramin derived from virginiamycin S1.", "category_aro_class_name": "Antibiotic"}, "37023": {"category_aro_accession": "3000679", "category_aro_cvterm_id": "37023", "category_aro_name": "vernamycin C", "category_aro_description": "Vernamycin C is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37024": {"category_aro_accession": "3000680", "category_aro_cvterm_id": "37024", "category_aro_name": "patricin A", "category_aro_description": "Patricin A is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37025": {"category_aro_accession": "3000681", "category_aro_cvterm_id": "37025", "category_aro_name": "patricin B", "category_aro_description": "Patricin B is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37026": {"category_aro_accession": "3000682", "category_aro_cvterm_id": "37026", "category_aro_name": "ostreogrycin B3", "category_aro_description": "Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid.", "category_aro_class_name": "Antibiotic"}, "37247": {"category_aro_accession": "3000867", "category_aro_cvterm_id": "37247", "category_aro_name": "oleandomycin", "category_aro_description": "Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.466262, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "36841", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALFLMTEVDISIL", "sequence_from_broadstreet": "MNKKNIKDSQNFITSKHHINEILRNVHLNTNDNIIEIGSGKGHFSFELAKRCNYVTAIEIDPKLCRITKNKLIEYENFQVINKDILQFKFPKNKSYKIFGNIPYNISTDIIRKIVFESTATESYLIVEYGFAKRLLNTNRSLALFLMTEVDISILSKIPREYFHPKPRVNSSLIVLKRHPSKISLKDRKQYENFVMKWVNKEYIKLFSKNQFYQALKYARIDDLNNISFEQFLSLFNSYKLFNR", "dna_sequence_from_broadstreet": "ATGAACAAAAAAAATATAAAAGATAGTCAAAACTTTATTACTTCAAAGCATCATATAAATGAAATTTTGAGAAATGTACATTTAAATACAAATGATAATATTATTGAGATTGGTTCAGGGAAAGGTCATTTCTCGTTTGAATTAGCTAAAAGGTGTAATTATGTAACCGCCATTGAAATAGATCCTAAATTATGTAGGATAACTAAAAACAAACTTATTGAATATGAGAACTTCCAGGTTATCAATAAAGATATTTTACAATTTAAGTTTCCTAAAAATAAGTCATATAAGATATTTGGAAATATACCCTACAATATAAGTACAGATATAATTCGAAAAATTGTTTTTGAAAGCACAGCTACAGAAAGTTATTTAATAGTGGAATATGGATTTGCTAAAAGGTTGCTAAATACAAATCGTTCACTAGCACTATTTTTAATGACAGAAGTTGATATATCCATATTAAGTAAAATCCCTAGAGAATACTTTCATCCAAAACCTAGAGTTAATAGCTCGTTAATTGTATTAAAAAGACACCCTTCAAAAATATCACTCAAAGATAGAAAACAATATGAAAATTTTGTTATGAAATGGGTTAACAAAGAATACATAAAACTATTTTCCAAAAACCAATTTTATCAAGCCTTAAAATATGCAAGAATTGACGATTTAAACAATATTAGCTTTGAACAATTCTTGTCTCTTTTCAATAGCTATAAATTATTTAATAGATAA", "partial": "0", "query_start": 1160, "query_end": 1216, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|2493|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "Nocardia rifampin resistant beta-subunit of RNA polymerase (rpoB2)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "2200", "model_id": "2831", "ARO_accession": "3000501", "ARO_name": "rpoB2", "ARO_category": {"36349": {"category_aro_accession": "3000210", "category_aro_cvterm_id": "36349", "category_aro_name": "rifamycin-resistant beta-subunit of RNA polymerase (rpoB)", "category_aro_description": "Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin.", "category_aro_class_name": "AMR Gene Family"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36656": {"category_aro_accession": "3000517", "category_aro_cvterm_id": "36656", "category_aro_name": "rifaximin", "category_aro_description": "Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase.", "category_aro_class_name": "Antibiotic"}, "36669": {"category_aro_accession": "3000530", "category_aro_cvterm_id": "36669", "category_aro_name": "rifabutin", "category_aro_description": "Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis.", "category_aro_class_name": "Antibiotic"}, "36673": {"category_aro_accession": "3000534", "category_aro_cvterm_id": "36673", "category_aro_name": "rifapentine", "category_aro_description": "Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy.", "category_aro_class_name": "Antibiotic"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "35998": {"category_aro_accession": "0001002", "category_aro_cvterm_id": "35998", "category_aro_name": "antibiotic target replacement", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.821022, "max_identities": 10, "bit_score": 22.7126, "cvterm_id": "41346", "query": "RLMTEHDLAMLYEWLNRSHIVE", "match": "R++TE D+A   E+L R H  E", "sequence_from_db": "RVLTEDDIAATIEYLVRLHAGE", "sequence_from_broadstreet": "MLEGRIVTVSSRTESPLAAPGVPGAPRRLSFARIREPLAVPGLLDIQTESFGWLIGAPDWCARAAARGTEPVAGLAEVLAEISPIEDFAGTMSLTLSDPRFEEVKASVEECKDKDLTYAAPWFVTAEFVNNNTGEIKSQTVFMGDFPMMTAHGTFVVNGTERVVVSQLVRSPGVYFDHAIDKGSEKDVHSARVIPSRGAWLEFDVDKRDTLGVRIDRKRRQPVTVLLKALGWSAERIAERFGFAPLIMASLAKDNVAGTDDALLEIHRKLRPGEPPTKESAQNLLANLFFTEKRYDLARVGRYKIDKKLGLRAPGAPRVLTEDDIAATIEYLVRLHAGERTMIAPGGVEVPVEVDDIDHFGNRRVRTVGELIQNQIRVGLSRMERVVRERMTTQDVEAITPQSLMNIRPVVAAMKEFFGTSQLSQFMDQRNPLASLTNKRRLSALGPGGLSRERAGLEVRDVHYSHYGRMCPIETPEGPNIGLMGYLSVYARVNPFGFVETPYRRVVDGRVTDEVDYLTADEEDRHVVAQANEPLDAEGRFLAARIPVRRKNSEVELVDSAAVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLIRSEAPIVGTGMELRAAVDAGDVVVNEKAGVVEEVSADYVTVMADDGTRKSYRMRKFNRSNQGTCSNQRPIVDEGQRVEAGQVLADGPCTENGEMALGKNLLVAIMPWEGHNYEDAIILSQRLVEQDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDDLPPGVNELVRVYVAQKRKIQDGDKLAGRHGNKGVIGKILPTEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWIGKAGWKVEGNPEWAKDLPEEMWEAPADSNIATPVFDGAREEELTGLLGSTLPNRDGERMVDDNGKAVLFDGRSGEPFPYPVAVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGDNIPEPGVPESFKVLLKELQALCLNVEVLSAGAAVELAHGVDDDHERTAANLGINLSRAESITETELSG", "dna_sequence_from_broadstreet": "GTGCTGGAAGGACGCATCGTGACAGTCTCGAGTCGGACCGAGTCCCCGCTCGCCGCGCCCGGAGTCCCGGGTGCGCCCCGGCGGCTCTCGTTCGCCAGAATCCGCGAGCCCCTGGCGGTTCCGGGCCTGCTGGACATTCAGACCGAATCGTTCGGGTGGCTGATCGGCGCACCCGACTGGTGCGCCCGCGCGGCAGCCCGCGGGACGGAACCGGTCGCCGGGCTGGCCGAGGTGCTCGCCGAGATCAGCCCCATCGAGGACTTCGCGGGCACGATGTCGCTGACGTTGTCCGATCCGCGGTTCGAGGAGGTCAAGGCCTCCGTCGAGGAGTGCAAGGACAAGGATCTGACCTATGCCGCGCCGTGGTTCGTCACGGCGGAATTCGTGAACAACAACACCGGCGAGATCAAGAGCCAGACCGTTTTCATGGGTGATTTCCCCATGATGACCGCGCACGGGACATTCGTCGTCAACGGCACCGAACGGGTGGTCGTGTCGCAACTGGTGCGCTCGCCGGGCGTGTACTTCGACCACGCGATCGACAAGGGTTCGGAGAAGGACGTGCACAGCGCGCGGGTGATCCCGTCGCGCGGTGCCTGGCTGGAGTTCGACGTCGACAAGCGCGACACCCTGGGCGTGCGCATCGACCGCAAGCGCCGTCAGCCGGTAACGGTGCTGCTCAAGGCGCTGGGCTGGAGTGCGGAGCGAATCGCCGAGCGATTCGGGTTCGCCCCGCTGATCATGGCCTCGCTGGCCAAGGACAACGTGGCGGGCACCGACGACGCTTTGCTCGAGATCCATCGCAAGCTGCGTCCGGGCGAGCCGCCGACCAAGGAGTCGGCACAGAACCTGCTGGCAAATCTGTTCTTCACCGAGAAGCGCTACGACCTGGCGCGGGTGGGCCGTTACAAGATCGACAAGAAGCTCGGGCTGCGCGCTCCGGGGGCACCGCGGGTGCTCACCGAGGACGACATCGCGGCCACCATCGAGTACCTGGTGCGCCTGCACGCCGGGGAGAGGACGATGATCGCGCCCGGCGGGGTCGAGGTGCCGGTGGAGGTCGACGACATCGACCATTTCGGTAACCGCCGGGTGCGCACCGTGGGTGAGCTGATCCAGAACCAGATCCGCGTGGGTCTGTCCCGGATGGAACGGGTGGTGCGGGAGCGCATGACCACCCAGGACGTCGAGGCGATCACGCCGCAGTCGCTGATGAACATCCGCCCGGTGGTCGCGGCGATGAAGGAGTTCTTCGGCACCTCGCAGCTGTCGCAGTTCATGGACCAGCGCAACCCGCTGGCGAGCCTGACCAACAAGCGGCGGCTGTCCGCGCTCGGGCCGGGCGGGCTCTCGCGCGAACGGGCCGGCTTGGAGGTCCGCGACGTGCACTACAGCCACTACGGCCGGATGTGCCCGATCGAGACGCCGGAGGGGCCGAACATCGGCCTGATGGGGTACCTGTCGGTGTACGCGCGGGTCAACCCGTTCGGTTTCGTCGAGACCCCCTACCGGCGGGTGGTGGACGGCCGGGTCACCGACGAGGTCGATTACCTCACCGCCGACGAGGAGGACCGGCACGTGGTGGCCCAGGCGAACGAACCGCTGGACGCCGAGGGCCGCTTCCTGGCCGCGCGAATCCCGGTGCGCCGGAAGAACTCCGAGGTGGAACTCGTCGATTCCGCCGCGGTGGATTACATGGATGTGTCGCCGCGGCAGATGGTGTCGGTGGCGACGGCGATGATTCCGTTCCTCGAGCATGATGATGCCAACCGTGCGCTGATGGGTGCGAATATGCAGCGTCAGGCGGTGCCGTTGATTCGGTCGGAGGCGCCGATCGTGGGTACCGGTATGGAGCTGCGTGCGGCGGTGGATGCCGGTGATGTGGTGGTGAACGAGAAGGCCGGTGTGGTCGAGGAGGTTTCGGCCGATTACGTCACGGTGATGGCCGATGACGGGACTCGTAAGTCGTATCGGATGCGGAAGTTCAACCGGTCGAATCAGGGGACGTGTTCGAATCAGCGGCCGATCGTGGACGAGGGTCAGCGGGTCGAGGCCGGGCAGGTGTTGGCTGATGGGCCGTGCACCGAGAACGGTGAGATGGCGCTGGGTAAGAACCTGTTGGTGGCGATCATGCCGTGGGAGGGGCACAACTACGAGGACGCGATCATCCTGTCGCAGCGGTTGGTGGAGCAGGATGTGTTGACCTCGATCCATATCGAGGAGCACGAGATCGATGCTCGTGACACCAAGCTCGGTGCCGAGGAGATCACTCGCGACATTCCGAATGTCTCCGATGAGGTGTTGGCGGATCTGGACGAGCGTGGCATCGTGCGGATCGGTGCGGAGGTGCGTGATGGTGACATCCTGGTCGGTAAGGTCACGCCCAAGGGTGAGACCGAGCTGACGCCGGAGGAGCGGTTGCTGCGGGCGATCTTCGGGGAGAAGGCGCGTGAGGTGCGTGATACCTCGTTGAAGGTGCCCCACGGTGAGTCGGGCAAGGTCATCGGGATCCGGGTGTTCTCTCGGGAGGACGATGACGATCTGCCGCCCGGTGTCAACGAGTTGGTGCGGGTGTATGTGGCGCAGAAGCGCAAGATCCAAGACGGTGACAAGCTGGCCGGTCGGCACGGGAACAAGGGTGTGATCGGCAAGATCCTGCCCACCGAGGACATGCCGTTCCTGCCCGATGGCACCCCGGTCGACATCATCCTCAACACCCACGGTGTGCCGCGGCGTATGAACATCGGCCAGATCCTGGAAACCCACCTCGGCTGGATCGGCAAAGCCGGCTGGAAGGTCGAGGGCAACCCCGAGTGGGCCAAGGATCTGCCGGAGGAGATGTGGGAGGCCCCCGCGGACTCCAACATCGCGACTCCGGTGTTCGACGGTGCCCGCGAGGAGGAGCTGACGGGTCTGCTGGGCTCGACGCTGCCCAACCGTGACGGTGAGCGGATGGTCGACGACAACGGCAAGGCCGTGCTGTTCGACGGTCGTTCCGGTGAGCCGTTCCCGTACCCGGTGGCGGTGGGCTACATGTACATCCTGAAGCTGCACCACCTGGTCGACGACAAGATCCACGCTCGCTCCACCGGCCCGTACTCGATGATCACCCAGCAGCCGCTCGGTGGTAAGGCCCAGTTCGGTGGCCAGCGCTTCGGTGAGATGGAGTGCTGGGCGATGCAGGCCTACGGCGCGGCCTACACCCTGCAGGAACTGCTCACGATCAAGTCCGACGACGTCGTCGGCCGCGTGAAGGTCTACGAGGCGATCGTCAAGGGCGACAACATCCCGGAACCCGGTGTGCCGGAATCGTTCAAGGTGTTGTTGAAGGAACTCCAGGCACTGTGCCTCAACGTCGAGGTGCTGTCCGCCGGTGCCGCGGTCGAACTGGCGCACGGGGTCGACGACGATCACGAGCGGACGGCCGCGAACCTCGGCATCAACCTGTCCCGCGCCGAATCCATCACGGAGACCGAGCTGTCCGGGTGA", "partial": "0", "query_start": 1184, "query_end": 1249, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 45.45}, "gnl|BL_ORD_ID|2301|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "AAC(6')-34", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2525", "ARO_accession": "3003989", "ARO_name": "AAC(6')-34", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.998271, "max_identities": 8, "bit_score": 22.7126, "cvterm_id": "40862", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+T+R + E D   L  WL+   +++++ G +", "sequence_from_db": "ITVRELEEKDEISLASWLSNPDVLQYYEGRD", "sequence_from_broadstreet": "MRIGDLIREDGGIAMLVYEAGPITVRELEEKDEISLASWLSNPDVLQYYEGRDNPHDVERVREHFYVDDDETRCIIKYEGKPIGYIQFYLLDEETLGEYGYNESDADCRTFATDQFIGEPDYWNRGIGTKLMTSMVEYLVFQRQADRIVMDPQAWNERAIACYEKCGFRKVRLLEKHEQHEGELRDCWIMEYRAERK", "dna_sequence_from_broadstreet": "ATGAGAATTGGGGATCTAATAAGGGAAGATGGGGGGATCGCGATGCTGGTGTACGAGGCTGGACCGATTACGGTTCGCGAGCTGGAGGAGAAGGATGAAATATCCTTAGCTTCTTGGCTGTCCAATCCGGATGTGCTGCAGTATTATGAGGGACGGGACAATCCTCACGACGTGGAGCGGGTGCGGGAGCATTTTTACGTGGATGATGATGAGACTCGCTGCATCATTAAATATGAGGGGAAACCGATCGGATATATTCAGTTTTATCTTCTGGATGAAGAGACGTTAGGCGAGTATGGATATAACGAGAGTGATGCAGACTGCAGAACCTTCGCCACGGATCAATTCATCGGGGAGCCGGATTATTGGAATCGAGGCATCGGTACGAAGCTCATGACTTCCATGGTGGAGTATCTCGTGTTTCAGAGGCAGGCTGATCGGATCGTAATGGACCCGCAGGCATGGAATGAACGGGCGATTGCTTGTTACGAAAAGTGCGGCTTCCGGAAGGTCAGACTGCTGGAGAAGCATGAACAGCATGAAGGTGAACTGCGGGACTGCTGGATTATGGAGTATCGGGCAGAGCGAAAGTAA", "partial": "0", "query_start": 1175, "query_end": 1267, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 25.81}, "gnl|BL_ORD_ID|1219|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "otr(A)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1273", "ARO_accession": "3002891", "ARO_name": "otr(A)", "ARO_category": {"35921": {"category_aro_accession": "0000002", "category_aro_cvterm_id": "35921", "category_aro_name": "tetracycline-resistant ribosomal protection protein", "category_aro_description": "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein.", "category_aro_class_name": "AMR Gene Family"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.54342, "max_identities": 7, "bit_score": 21.557, "cvterm_id": "36773", "query": "LMTEHDLAMLYEWLNRSHIV", "match": "L+ +HD A L  +L+  H++", "sequence_from_db": "LLADHDDAFLTAYLDEEHVL", "sequence_from_broadstreet": "MNKLNLGILAHVDAGKTSLTERLLHRTGVIDEVGSVDAGTTTTDSMELERQRGITIRSAVATFVLDDLKVNLIDTPGHSDFISEVERALGVLDGAVLVVSAVEGVQPQTRILMRTLRRLGIPTLVFVNKIDRGGARPDGVLREIRDRLTPAAVALSAVADAGTPRARAIALGPDTDPDFAVRVGELLADHDDAFLTAYLDEEHVLTEKEYAEELAAQTARGLVHPVYFGSALTGEGLDHLVHGIRELLPSVHASQDAPLRATVFKVDRGARGEAVAYLRLVSGTLGTRDSVTLHRVDHTGRVTEHAGRITALRVFEHGSATSETRATAGDIAQAWGLKDVRVGDRAGHLDGPPPRNFFAPPSLETVIRPERPEEAGRLHAALRMLDEQDPSIDLRQDEENAAGAVVRLYGEVQKEILGSTLAESFGVRVRFDPTRTVCIEKPVGTGEALIELDTRTHNYFWGAPWVCASDRPSPARAITFRLAVELGSLPLAFHKAIEETVHTTLRHGLYGWQVTDCAVTLTRTGVRSPVSAADDFRKANARLVLMDALGRAGTEVHEPVSSFELEVPAARLSPVLAKLAELGATPGVPTAEGDVFRLEGTMPTSLVHDFNQRVPGLTQGEGVFLAEHRGYRPAVGQPPVRPRPEGPNPLNRDEYILHVLKRV", "dna_sequence_from_broadstreet": "ATGAACAAGCTGAATCTGGGCATCCTGGCCCACGTTGACGCCGGCAAGACCAGCCTCACCGAGCGCCTGCTGCACCGCACCGGTGTGATCGACGAGGTCGGCAGCGTGGACGCCGGCACCACGACGACCGACTCGATGGAGCTGGAGCGGCAGCGCGGCATCACCATCCGGTCCGCCGTGGCCACGTTCGTCCTGGACGATCTCAAGGTCAACCTCATCGACACCCCGGGCCACTCCGACTTCATCTCCGAGGTCGAGCGGGCGCTCGGGGTGCTCGACGGCGCGGTCCTGGTGGTCTCGGCCGTCGAGGGCGTCCAGCCGCAGACCCGCATCCTGATGCGGACCCTGCGCAGGCTGGGCATTCCCACGCTGGTCTTCGTCAACAAGATCGACCGGGGCGGCGCGCGTCCCGACGGTGTGCTGCGGGAGATCCGCGACCGGCTCACCCCCGCCGCGGTGGCACTGTCCGCCGTGGCGGACGCCGGCACGCCGCGGGCCCGCGCGATCGCGCTCGGCCCGGACACCGACCCGGACTTCGCCGTCCGGGTCGGTGAGCTGCTGGCCGACCACGACGACGCGTTCCTCACCGCCTACCTGGACGAGGAACACGTACTGACCGAGAAGGAGTACGCGGAGGAACTGGCCGCGCAGACCGCGCGCGGTCTGGTGCACCCGGTGTACTTCGGGTCCGCGCTGACCGGCGAGGGCCTGGACCATCTGGTGCACGGCATCCGGGAGTTGCTGCCGTCCGTGCACGCGTCGCAGGACGCGCCGCTGCGGGCCACCGTGTTCAAGGTGGACCGTGGCGCGCGCGGCGAGGCCGTCGCGTACCTGCGGCTGGTCTCCGGCACGCTGGGCACCCGCGATTCGGTGACGCTGCACCGCGTCGACCACACCGGCCGGGTCACCGAGCACGCCGGACGCATCACCGCGCTGCGGGTCTTCGAGCACGGGTCGGCCACCAGCGAGACCCGGGCGACCGCCGGGGACATCGCGCAGGCGTGGGGCCTGAAGGACGTACGGGTCGGTGACCGGGCCGGGCACCTCGACGGTCCCCCGCCGCGCAACTTCTTCGCGCCGCCCAGCCTGGAGACCGTGATCAGGCCGGAGCGCCCGGAGGAAGCGGGACGGCTGCACGCCGCGCTGCGCATGCTGGACGAGCAGGACCCCTCGATCGACCTGCGGCAGGACGAGGAGAACGCGGCCGGCGCGGTGGTCCGCCTCTACGGGGAGGTGCAGAAGGAGATCCTCGGCAGCACGCTCGCGGAGTCCTTCGGCGTACGGGTGCGCTTCGACCCGACCCGTACGGTCTGCATCGAAAAGCCCGTGGGGACCGGCGAGGCGCTGATCGAGCTGGACACGCGGACGCACAACTACTTCTGGGGCGCACCGTGGGTCTGCGCGTCGGACCGGCCGAGCCCGGCGCGGGCGATCACGTTCCGTTTGGCGGTGGAACTGGGCTCGCTCCCCCTGGCCTTCCACAAGGCCATCGAGGAGACGGTGCACACCACCCTGCGGCACGGTCTGTACGGCTGGCAGGTCACCGACTGCGCCGTCACCCTGACCCGTACCGGCGTTCGCAGTCCGGTCAGCGCGGCCGACGACTTCCGCAAGGCCAACGCGCGCTTGGTCCTGATGGACGCGCTCGGCAGGGCCGGTACGGAGGTGCACGAGCCGGTCAGCTCCTTCGAACTGGAGGTGCCCGCCGCCCGGCTCAGCCCGGTACTTGCGAAACTCGCGGAACTGGGCGCGACGCCCGGTGTGCCCACGGCCGAGGGGGACGTCTTCCGCCTGGAGGGCACGATGCCGACCAGCCTCGTGCACGACTTCAACCAGCGGGTTCCCGGACTGACCCAGGGCGAGGGCGTGTTCCTGGCCGAGCACCGGGGCTACCGGCCCGCCGTCGGACAGCCGCCCGTGCGGCCGCGGCCCGAGGGGCCCAACCCGCTCAACCGCGACGAGTACATCCTGCACGTGCTCAAGCGCGTGTGA", "partial": "0", "query_start": 1187, "query_end": 1246, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 35.0}, "gnl|BL_ORD_ID|2106|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "salA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1100", "model_id": "2265", "ARO_accession": "3003749", "ARO_name": "salA", "ARO_category": {"41687": {"category_aro_accession": "3004469", "category_aro_cvterm_id": "41687", "category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins.", "category_aro_class_name": "AMR Gene Family"}, "37716": {"category_aro_accession": "3001317", "category_aro_cvterm_id": "37716", "category_aro_name": "pleuromutilin", "category_aro_description": "Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36218": {"category_aro_accession": "3000079", "category_aro_cvterm_id": "36218", "category_aro_name": "oxazolidinone antibiotic", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37014": {"category_aro_accession": "3000670", "category_aro_cvterm_id": "37014", "category_aro_name": "pleuromutilin antibiotic", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.26075, "max_identities": 8, "bit_score": 21.1718, "cvterm_id": "40406", "query": "MTEHDLAMLYEWLNRSHIVE", "match": "M E DL   Y+W    +I+E", "sequence_from_db": "MMEQDLTPYYDWTVMDYIIE", "sequence_from_broadstreet": "MLFLFEEKALEVEHKVLIPELTFSIEDHEHLAIVGVNGVGKSTLLKVIHQDQSVDSAMMEQDLTPYYDWTVMDYIIESYPEIAKIRLQLNHTDMINKYIELDGYIIEGEIVTEAKKLGIKEEQLEQKISTLSGGEQTKVSFLKVKMSKASLLLIDEPTNHMDLEMKEWLTKAFKQEQRAILFVSHDRTFLNETPDAILELSLDGAKKYIGKYDKYKQQKDIEHETLKLQYEKQQKEQAAIEETIKKYKAWYQKAEQSASVRSPYQQKQLSKLAKRFKSKEQQLNRKLDQEHIPNPHKKEKTFSIQHHNFKSHYLVQFNHVSFAYDNRKIFDDVSFYIKRNQNVIVEGRNGTGKSTLIKLILGELEPTKGDITVHPELEIGYFSQDFENLNMHHTVLDEILEIPEMKEADARTILASFYFDKDRINDVVETLSMGEKCRLQFVKLYFSNPHIMILDEPTNYFDIGMQENIIQLIQSFQGSVLIVSHDNYFKSQIKDQTWTIKNHQMTHENVQVKDPINTESMKHHLKELEQYTDERNRETEF", "dna_sequence_from_broadstreet": "ATGCTATTTTTATTTGAAGAAAAAGCATTAGAAGTTGAACATAAAGTATTAATACCCGAGTTGACTTTTTCAATAGAGGACCATGAACATTTAGCAATCGTTGGTGTTAATGGTGTTGGAAAATCAACATTATTAAAAGTCATTCATCAAGATCAATCAGTTGATTCAGCGATGATGGAACAAGATTTAACACCTTATTATGATTGGACTGTTATGGATTATATAATTGAATCATATCCTGAAATCGCAAAGATTAGATTGCAACTTAATCATACAGATATGATTAATAAATATATTGAATTAGATGGATACATTATAGAAGGTGAAATCGTAACAGAAGCAAAAAAGCTCGGAATAAAAGAGGAACAACTAGAACAGAAAATTTCTACTTTAAGTGGTGGAGAACAAACAAAAGTATCATTTTTAAAAGTGAAAATGTCTAAAGCATCATTACTATTAATCGATGAACCAACAAACCACATGGATTTAGAAATGAAGGAATGGTTGACGAAAGCTTTTAAACAAGAACAACGTGCTATATTATTTGTATCTCATGACCGAACATTTTTAAATGAAACGCCAGATGCTATATTAGAATTGAGTCTTGATGGGGCTAAGAAGTATATCGGTAAATACGATAAATACAAACAACAAAAAGATATAGAGCATGAAACATTAAAGCTACAGTATGAAAAACAACAAAAAGAACAAGCGGCCATTGAAGAAACGATTAAAAAATATAAAGCATGGTATCAAAAAGCAGAACAAAGTGCTTCTGTGAGAAGCCCATATCAACAAAAACAATTAAGTAAGTTAGCGAAACGGTTTAAATCAAAAGAACAACAATTAAATCGTAAACTTGATCAAGAGCATATCCCAAATCCACATAAAAAAGAGAAAACTTTCTCAATACAACATCATAATTTTAAATCACATTATTTAGTTCAATTTAATCATGTTTCGTTTGCTTATGATAACCGGAAAATATTCGATGATGTATCATTCTATATTAAGCGAAATCAAAATGTTATTGTTGAAGGCAGAAATGGTACAGGTAAATCAACTTTAATCAAATTGATACTCGGTGAACTCGAGCCAACTAAAGGTGATATAACTGTTCATCCAGAATTAGAAATTGGATATTTCTCTCAAGATTTTGAGAATTTAAATATGCATCATACTGTCTTAGATGAAATATTAGAAATTCCTGAAATGAAAGAAGCAGATGCAAGAACCATATTAGCAAGCTTTTATTTTGATAAAGATAGGATAAATGATGTTGTTGAAACACTATCGATGGGTGAAAAATGTAGGTTACAATTTGTAAAATTATATTTTTCAAATCCTCATATTATGATATTAGATGAGCCAACAAACTATTTCGATATTGGCATGCAAGAAAATATCATTCAATTAATACAATCATTTCAAGGTTCGGTCCTTATTGTATCTCATGATAATTATTTTAAATCACAAATTAAAGATCAGACTTGGACTATAAAAAATCATCAAATGACGCATGAAAATGTTCAAGTCAAAGATCCTATTAATACAGAATCTATGAAACATCATTTAAAAGAATTAGAACAATATACAGATGAAAGAAATCGTGAAACAGAGTTCTAG", "partial": "0", "query_start": 1190, "query_end": 1249, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 40.0}, "gnl|BL_ORD_ID|2095|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.03791, "max_identities": 9, "bit_score": 20.7866, "cvterm_id": "42594", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 1175, "query_end": 1228, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2094|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 1130, "orf_end": 1270, "orf_from": "NODE_54_length_1272_cov_25.1921_2 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.03791, "max_identities": 9, "bit_score": 20.7866, "cvterm_id": "40382", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 1175, "query_end": 1228, "orf_dna_sequence": "ATGAAAAACACAATACACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MKNTIHSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}}, "NODE_57_length_1134_cov_34.8908_1 # 25 # 864 # -1 # ID=57_1;partial=00;start_type=ATG;rbs_motif=GGAGG;rbs_spacer=5-10bp;gc_cont=0.615": {"gnl|BL_ORD_ID|1003|hsp_num:0": {"type_match": "Perfect", "model_id": "1070", "orf_strand": "-", "orf_start": 25, "orf_end": 864, "orf_from": "NODE_57_length_1134_cov_34.8908_1", "model_name": "sul1", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "500", "ARO_accession": "3000410", "ARO_name": "sul1", "ARO_category": {"41402": {"category_aro_accession": "3004238", "category_aro_cvterm_id": "41402", "category_aro_name": "sulfonamide resistant sul", "category_aro_description": "The sul genes encode forms of dihydropteroate synthase that confer resistance to sulfonamide.", "category_aro_class_name": "AMR Gene Family"}, "36463": {"category_aro_accession": "3000324", "category_aro_cvterm_id": "36463", "category_aro_name": "sulfadiazine", "category_aro_description": "Sulfadiazine is a potent inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids.", "category_aro_class_name": "Antibiotic"}, "36464": {"category_aro_accession": "3000325", "category_aro_cvterm_id": "36464", "category_aro_name": "sulfadimidine", "category_aro_description": "Sulfadimidine is an alkaline sulfonamide antibiotic that inhibits dihydropteroate synthase, and enzyme in the tetrahydrofolic acid biosynthesis pathway. This interferes with the production of folate, which is a precursor to many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36466": {"category_aro_accession": "3000327", "category_aro_cvterm_id": "36466", "category_aro_name": "sulfadoxine", "category_aro_description": "Sulfadoxine is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids.", "category_aro_class_name": "Antibiotic"}, "36468": {"category_aro_accession": "3000329", "category_aro_cvterm_id": "36468", "category_aro_name": "sulfamethoxazole", "category_aro_description": "Sulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.", "category_aro_class_name": "Antibiotic"}, "36469": {"category_aro_accession": "3000330", "category_aro_cvterm_id": "36469", "category_aro_name": "sulfisoxazole", "category_aro_description": "Sulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids.", "category_aro_class_name": "Antibiotic"}, "37027": {"category_aro_accession": "3000683", "category_aro_cvterm_id": "37027", "category_aro_name": "sulfacetamide", "category_aro_description": "Sulfacetamide is a very soluable sulfonamide antibiotic previously used to treat urinary tract infections. Its relatively low activity and toxicity to those with Stevens-Johnson syndrome have reduced its use and availability.", "category_aro_class_name": "Antibiotic"}, "37028": {"category_aro_accession": "3000684", "category_aro_cvterm_id": "37028", "category_aro_name": "mafenide", "category_aro_description": "Mafenide is a sulfonamide used topically for treating burns.", "category_aro_class_name": "Antibiotic"}, "37042": {"category_aro_accession": "3000698", "category_aro_cvterm_id": "37042", "category_aro_name": "sulfasalazine", "category_aro_description": "Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis.", "category_aro_class_name": "Antibiotic"}, "37043": {"category_aro_accession": "3000699", "category_aro_cvterm_id": "37043", "category_aro_name": "sulfamethizole", "category_aro_description": "Sulfamethizole is a short-acting sulfonamide that inhibits dihydropteroate synthetase.", "category_aro_class_name": "Antibiotic"}, "36421": {"category_aro_accession": "3000282", "category_aro_cvterm_id": "36421", "category_aro_name": "sulfonamide antibiotic", "category_aro_description": "Sulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.", "category_aro_class_name": "Drug Class"}, "35998": {"category_aro_accession": "0001002", "category_aro_cvterm_id": "35998", "category_aro_name": "antibiotic target replacement", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 553.132, "max_identities": 279, "cvterm_id": "39525", "query": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "match": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "sequence_from_db": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "sequence_from_broadstreet": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "dna_sequence_from_broadstreet": "ATGGTGACGGTGTTCGGCATTCTGAATCTCACCGAGGACTCCTTCTTCGATGAGAGCCGGCGGCTAGACCCCGCCGGCGCTGTCACCGCGGCGATCGAAATGCTGCGAGTCGGATCAGACGTCGTGGATGTCGGACCGGCCGCCAGCCATCCGGACGCGAGGCCTGTATCGCCGGCCGATGAGATCAGACGTATTGCGCCGCTCTTAGACGCCCTGTCCGATCAGATGCACCGTGTTTCAATCGACAGCTTCCAACCGGAAACCCAGCGCTATGCGCTCAAGCGCGGCGTGGGCTACCTGAACGATATCCAAGGATTTCCTGACCCTGCGCTCTATCCCGATATTGCTGAGGCGGACTGCAGGCTGGTGGTTATGCACTCAGCGCAGCGGGATGGCATCGCCACCCGCACCGGTCACCTTCGACCCGAAGACGCGCTCGACGAGATTGTGCGGTTCTTCGAGGCGCGGGTTTCCGCCTTGCGACGGAGCGGGGTCGCTGCCGACCGGCTCATCCTCGATCCGGGGATGGGATTTTTCTTGAGCCCCGCACCGGAAACATCGCTGCACGTGCTGTCGAACCTTCAAAAGCTGAAGTCGGCGTTGGGGCTTCCGCTATTGGTCTCGGTGTCGCGGAAATCCTTCTTGGGCGCCACCGTTGGCCTTCCTGTAAAGGATCTGGGTCCAGCGAGCCTTGCGGCGGAACTTCACGCGATCGGCAATGGCGCTGACTACGTCCGCACCCACGCGCCTGGAGATCTGCGAAGCGCAATCACCTTCTCGGAAACCCTCGCGAAATTTCGCAGTCGCGACGCCAGAGACCGAGGGTTAGATCATGCCTAG", "partial": "0", "query_start": 25, "query_end": 861, "orf_dna_sequence": "ATGGTGACGGTGTTCGGCATTCTGAATCTCACCGAGGACTCCTTCTTCGATGAGAGCCGGCGGCTAGACCCCGCCGGCGCTGTCACCGCGGCGATCGAAATGCTGCGAGTCGGATCAGACGTCGTGGATGTCGGACCGGCCGCCAGCCATCCGGACGCGAGGCCTGTATCGCCGGCCGATGAGATCAGACGTATTGCGCCGCTCTTAGACGCCCTGTCCGATCAGATGCACCGTGTTTCAATCGACAGCTTCCAACCGGAAACCCAGCGCTATGCGCTCAAGCGCGGCGTGGGCTACCTGAACGATATCCAAGGATTTCCTGACCCTGCGCTCTATCCCGATATTGCTGAGGCGGACTGCAGGCTGGTGGTTATGCACTCAGCGCAGCGGGATGGCATCGCCACCCGCACCGGTCACCTTCGACCCGAAGACGCGCTCGACGAGATTGTGCGGTTCTTCGAGGCGCGGGTTTCCGCCTTGCGACGGAGCGGGGTCGCTGCCGACCGGCTCATCCTAGATCCGGGGATGGGATTTTTCTTGAGCCCCGCACCGGAAACATCGCTGCACGTGCTGTCGAACCTTCAAAAGCTGAAGTCGGCGTTGGGGCTTCCGCTATTGGTCTCGGTGTCGCGGAAATCCTTCTTGGGCGCCACCGTTGGCCTTCCTGTAAAGGATCTGGGTCCAGCGAGCCTTGCGGCGGAACTTCACGCGATCGGCAATGGCGCTGACTACGTCCGCACCCACGCGCCTGGAGATCTGCGAAGCGCAATCACCTTCTCGGAAACCCTCGCGAAATTTCGCAGTCGCGACGCCAGAGACCGAGGGTTAGATCATGCCTAG", "orf_prot_sequence": "MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA", "perc_identity": 100.0}}, "NODE_69_length_625_cov_55.4398_1 # 63 # 623 # -1 # ID=69_1;partial=01;start_type=Edge;rbs_motif=None;rbs_spacer=None;gc_cont=0.542": {"gnl|BL_ORD_ID|1285|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib10", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1370", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002581", "ARO_name": "AAC(6')-Ib10", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.16864e-140, "bit_score": 385.185, "max_identities": 186, "cvterm_id": "36752", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 100.0}, "gnl|BL_ORD_ID|937|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib9", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "993", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002580", "ARO_name": "AAC(6')-Ib9", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.39704e-139, "bit_score": 382.874, "max_identities": 185, "cvterm_id": "36752", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 99.46}, "gnl|BL_ORD_ID|1001|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib3", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1068", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002576", "ARO_name": "AAC(6')-Ib3", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.74224e-138, "bit_score": 379.022, "max_identities": 183, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATTGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 99.46}, "gnl|BL_ORD_ID|1950|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib8", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "2071", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002579", "ARO_name": "AAC(6')-Ib8", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33948e-137, "bit_score": 380.178, "max_identities": 184, "cvterm_id": "36884", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNS DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MSLKPGPKRIAESTGQPDQRQRDNKKTPGNTDKLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCCTTAAACCCGGACCAAAAAGAATTGCCGAATCGACGGGGCAACCTGATCAACGCCAACGCGACAATAAAAAGACGCCTGGAAATACTGACAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.92}, "gnl|BL_ORD_ID|1582|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib-cr", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1678", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002547", "ARO_name": "AAC(6')-Ib-cr", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.66084e-137, "bit_score": 377.867, "max_identities": 184, "cvterm_id": "35914", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDG WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTP GPAVYMVQTRQAFERTRSDA", "sequence_from_db": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.92}, "gnl|BL_ORD_ID|945|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib4", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1002", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002577", "ARO_name": "AAC(6')-Ib4", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.84326e-137, "bit_score": 376.326, "max_identities": 182, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.91}, "gnl|BL_ORD_ID|53|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "63", "pass_evalue": "n/a", "pass_bitscore": "350", "ARO_accession": "3002546", "ARO_name": "AAC(6')-Ib", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.97025e-136, "bit_score": 375.555, "max_identities": 181, "cvterm_id": "35915", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFE+QGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTAACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAAGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.37}, "gnl|BL_ORD_ID|1162|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib'", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1235", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3003676", "ARO_name": "AAC(6')-Ib'", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.43592e-135, "bit_score": 373.629, "max_identities": 181, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRS A", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.37}, "gnl|BL_ORD_ID|1702|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib11", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1801", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002582", "ARO_name": "AAC(6')-Ib11", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.40982e-135, "bit_score": 373.244, "max_identities": 181, "cvterm_id": "35732", "query": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "+I  NSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGID  LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "TIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MKNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCTGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 63, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 97.31}, "gnl|BL_ORD_ID|411|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib-Suzhou", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "444", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002591", "ARO_name": "AAC(6')-Ib-Suzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.1426e-128, "bit_score": 354.755, "max_identities": 171, "cvterm_id": "36884", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTR DA", "sequence_from_db": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "sequence_from_broadstreet": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCATGGATGCCTAA", "partial": "0", "query_start": 105, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 99.42}, "gnl|BL_ORD_ID|944|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-Ib-Hangzhou", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1000", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002592", "ARO_name": "AAC(6')-Ib-Hangzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.18675e-127, "bit_score": 352.829, "max_identities": 170, "cvterm_id": "35507", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "MTEHDL MLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQ LANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_db": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "sequence_from_broadstreet": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGTGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 105, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 98.84}, "gnl|BL_ORD_ID|1481|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-32", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1577", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002586", "ARO_name": "AAC(6')-32", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.23597e-106, "bit_score": 299.671, "max_identities": 142, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "++ S   VTLRLMTE DL ML+ WLNR HIVEWWGGEE RPTL +V + YLP VLA+E+VTPYIAML  EPIGYAQSYVALGSGDGWWE+ETDPGVRGIDQ L+N +QL +GLGTKLV+ALVELLF+DP VTKIQTDP+P+N RAIRCYEKAGF +Q  +TTPDGPAVYMVQTRQAFER RS A", "sequence_from_db": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "sequence_from_broadstreet": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "dna_sequence_from_broadstreet": "ATGTCCCCGAGCAAAACACCCGTTACCTTGCGCCTCATGACCGAGCGCGACCTACCGATGCTGCATGCATGGCTGAACCGGCCGCACATTGTCGAGTGGTGGGGTGGAGAAGAAGAACGCCCGACTCTTCATGAAGTGGTCAAACACTACCTGCCGAGGGTTTTGGCAGAAGAAGCCGTCACACCATACATCGCGATGTTGGGCGACGAACCCATCGGCTACGCTCAGTCATACGTCGCACTCGGAAGCGGTGATGGATGGTGGGAGGATGAAACCGACCCAGGCGTACGAGGGATAGACCAATTCCTGTCGAACCATACACAGTTGAACCAGGGCCTAGGTACAAAGCTCGTCCAGGCACTCGTTGAACTGCTGTTCTCAGATCCTACCGTGACGAAGATCCAAACCGACCCGGCGCCAAACAACCATCGAGCGATTCGCTGCTACGAGAAAGCTGGCTTTGTTCAGCAAAACGTCATCACCACACCAGACGGCCCAGCCGTCTACATGGTTCAAACCAGGCAGGCCTTCGAGCGTGTGCGCAGTGCTGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 77.17}, "gnl|BL_ORD_ID|1563|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-IIa", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "1657", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002594", "ARO_name": "AAC(6')-IIa", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.22253e-104, "bit_score": 295.434, "max_identities": 140, "cvterm_id": "35731", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "match": "++ S   +TLRLMTE DL ML++WLNR HIVEWWGG+E RPTL +V E YLP  +A+ESVTPYIAML  EPIGYAQSYVALGSGDGWWE+ETDPGVRGIDQ LA+ +QL KGLGT+LVRALVELLF+DP VTKIQTDP+P+N RAIRCYEKAGF R+  +TTPDGPAVYMVQTRQAFER R  A", "sequence_from_db": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "sequence_from_broadstreet": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "dna_sequence_from_broadstreet": "ATGTCCGCGAGCACCCCCCCCATAACTCTTCGCCTCATGACCGAGCGCGACCTGCCGATGCTCCATGATTGGCTCAACCGGCCGCACATCGTTGAGTGGTGGGGTGGTGACGAAGAGCGACCGACTCTTGATGAAGTGCTGGAACACTACCTGCCCAGAGCGATGGCGGAAGAGTCCGTAACACCGTACATCGCAATGCTGGGCGAGGAACCGATCGGCTATGCTCAGTCGTACGTCGCGCTCGGAAGCGGTGATGGCTGGTGGGAAGATGAAACTGATCCAGGAGTGCGAGGAATAGACCAGTCTCTGGCTGACCCGACACAGTTGAACAAAGGCCTAGGAACAAGGCTTGTCCGCGCTCTCGTTGAACTACTGTTCTCGGACCCCACCGTGACGAAGATTCAGACCGACCCGACTCCGAACAACCATCGAGCCATACGCTGCTATGAGAAGGCAGGATTCGTGCGGGAGAAGATCATCACCACGCCTGACGGGCCGGCGGTTTACATGGTTCAAACACGACAAGCCTTCGAGAGAAAGCGCGGTGTTGCCTAA", "partial": "0", "query_start": 69, "query_end": 620, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 76.09}, "gnl|BL_ORD_ID|687|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 63, "orf_end": 623, "orf_from": "NODE_69_length_625_cov_55.4398_1", "model_name": "AAC(6')-IIc", "model_type": "protein homolog model", "model_type_id": 40292, "model_id": "730", "pass_evalue": "n/a", "pass_bitscore": "275", "ARO_accession": "3002596", "ARO_name": "AAC(6')-IIc", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.40724e-102, "bit_score": 288.886, "max_identities": 134, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRS", "match": "++ +N ++ LR+M E+DL ML+ WLNR HIVEWWGGE+ RPTL +V E Y P VLA+++V PYIAML+ EPIGYAQSY+ALGSGDGWWE+ETDPGVRGIDQ LAN SQL KGLGTKLVR+LVELLF+DP VTKIQTDPSPSN RAIRCYEKAGF ++  + TPDGPAVYMVQTRQAFE  R+", "sequence_from_db": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRT", "sequence_from_broadstreet": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRTVQSFKIKGKWS", "dna_sequence_from_broadstreet": "ATGTCCGCCAACAATGCCGCAATAGTTCTACGAGTCATGGCCGAGAACGATCTGCCAATGCTCCATGCTTGGCTGAACCGCCCCCACATAGTCGAGTGGTGGGGCGGCGAGGATGAACGCCCAACTCTTGACGAAGTCTTAGAACACTATTCGCCCGAAGTTCTGGCAAAGCAAGCTGTAGTGCCTTACATCGCAATGCTAGATGACGAACCCATCGGCTACGCCCAATCCTACATCGCACTTGGAAGTGGCGATGGATGGTGGGAAGACGAAACTGATCCAGGGGTCCGCGGGATTGACCAGTCTTTGGCTAATCCATCACAGTTAAACAAGGGGTTGGGTACAAAGCTCGTACGCTCGCTCGTTGAACTCCTGTTTAGCGACCCGGCCGTAACGAAAATCCAAACCGATCCATCTCCTAGCAACCATCGCGCCATTCGCTGCTACGAGAAGGCCGGGTTCGTTCAAGAAAAAAACATCCTCACACCTGACGGCCCTGCGGTGTACATGGTCCAAACACGCCAGGCGTTCGAAAGCCTGCGCACTGTTCAAAGCTTCAAAATCAAGGGGAAGTGGTCATGA", "partial": "0", "query_start": 69, "query_end": 614, "orf_dna_sequence": "AGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "orf_prot_sequence": "SIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "perc_identity": 73.63}}, "NODE_185_length_335_cov_33.8077_1 # 172 # 333 # 1 # ID=185_1;partial=01;start_type=ATG;rbs_motif=GGAG/GAGG;rbs_spacer=5-10bp;gc_cont=0.494": {"gnl|BL_ORD_ID|1582|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib-cr", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1678", "ARO_accession": "3002547", "ARO_name": "AAC(6')-Ib-cr", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.79463e-36, "max_identities": 54, "bit_score": 115.931, "cvterm_id": "35914", "query": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGRWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPYGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGACGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCATATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 172, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|937|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib9", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "993", "ARO_accession": "3002580", "ARO_name": "AAC(6')-Ib9", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.52072e-33, "max_identities": 51, "bit_score": 109.768, "cvterm_id": "36752", "query": "SNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "S  KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 175, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1285|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib10", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1370", "ARO_accession": "3002581", "ARO_name": "AAC(6')-Ib10", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.58816e-33, "max_identities": 51, "bit_score": 109.768, "cvterm_id": "36752", "query": "SNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "S  KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MLRSSSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGTTACGCAGCAGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 175, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1960|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib7", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "475", "model_id": "2117", "ARO_accession": "3002578", "ARO_name": "AAC(6')-Ib7", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.03278e-32, "max_identities": 51, "bit_score": 107.071, "cvterm_id": "35906", "query": "SNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "S  KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MRSRNWSRTLTERSGGNGAVAVFMACYDCFFVQSMPRASKQQARYAVGRCLMLWSSNDVTQQGSRPKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGCGCTCACGCAACTGGTCCAGAACCTTGACCGAACGCAGCGGTGGTAACGGCGCAGTGGCGGTTTTCATGGCTTGTTATGACTGTTTTTTTGTACAGTCTATGCCTCGGGCATCCAAGCAGCAAGCGCGTTACGCCGTGGGTCGATGTTTGATGTTATGGAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 175, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.23, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2046|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "339", "ARO_accession": "3002598", "ARO_name": "ANT(3'')-Ii-AAC(6')-IId fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "41439": {"category_aro_accession": "3004275", "category_aro_cvterm_id": "41439", "category_aro_name": "ANT(3'')", "category_aro_description": "Nucleotidylylation of streptomycin at the hydroxyl group at position 3''", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.23962e-31, "max_identities": 50, "bit_score": 107.457, "cvterm_id": "36783", "query": "AKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+KTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "SKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSNAVPAEISVQLSLALNAIERHLESTLLAVHLYGSALDGGLKPYSDIDLLVTVAAQLDETVRQALVVDLLEISASPGQSEALRALEVTIVVHGDVVPWRYPARRELQFGEWQRKDILAGIFEPATTDVDLAILLTKVRQHSLALAGSAAEDFFNPVPEGDLFKALSDTLKLWNSQPDWEGDERNVVLTLSRIWYSAATGKIAPKDIVANWAIERLPDQHKPVLLEARQAYLGRGEDCLASRADQLAAFVHFVKHEATKLLGAMPVMSKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGTAACGCAGTACCCGCCGAGATTTCGGTACAGCTATCACTGGCTCTCAACGCCATCGAGCGTCATCTGGAATCAACGTTGCTGGCCGTGCATTTGTACGGCTCTGCACTGGACGGTGGCCTGAAGCCATACAGTGATATTGATTTGCTGGTTACTGTGGCTGCACAGCTCGATGAGACTGTCCGACAAGCCCTGGTCGTAGATCTCTTGGAAATTTCTGCCTCCCCTGGCCAAAGTGAGGCTCTCCGCGCCTTGGAAGTTACCATCGTCGTGCATGGTGATGTTGTCCCTTGGCGTTATCCGGCCAGACGGGAACTGCAATTCGGGGAGTGGCAGCGTAAAGACATTCTTGCGGGCATCTTCGAGCCCGCCACAACCGATGTTGATCTGGCTATTCTGCTAACTAAAGTAAGGCAGCATAGCCTTGCATTGGCAGGTTCGGCCGCAGAGGATTTCTTTAACCCAGTTCCGGAAGGCGATCTATTCAAGGCATTGAGCGACACTCTGAAACTATGGAATTCGCAGCCGGATTGGGAAGGCGATGAGCGGAATGTAGTGCTTACCTTGTCTCGCATTTGGTACAGCGCAGCAACCGGCAAGATCGCACCGAAGGATATCGTTGCCAACTGGGCAATTGAGCGTCTGCCAGATCAACATAAGCCCGTACTGCTTGAAGCCCGGCAGGCTTATCTTGGACGAGGAGAAGATTGCTTGGCCTCACGCGCGGATCAGTTGGCGGCGTTCGTTCACTTCGTGAAACATGAAGCCACTAAATTGCTTGGTGCCATGCCAGTGATGTCTAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 181, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 98.04, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1950|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib8", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2071", "ARO_accession": "3002579", "ARO_name": "AAC(6')-Ib8", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 6.35836e-30, "max_identities": 47, "bit_score": 100.908, "cvterm_id": "36884", "query": "KLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "KLGITKYSIVTNS DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "KLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSLKPGPKRIAESTGQPDQRQRDNKKTPGNTDKLGITKYSIVTNSTDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCCTTAAACCCGGACCAAAAAGAATTGCCGAATCGACGGGGCAACCTGATCAACGCCAACGCGACAATAAAAAGACGCCTGGAAATACTGACAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCACCGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 190, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.92, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|865|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "922", "ARO_accession": "3002599", "ARO_name": "AAC(6')-30/AAC(6')-Ib' fusion protein", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.11286e-29, "max_identities": 47, "bit_score": 100.138, "cvterm_id": "36752", "query": "LGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "LGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "LGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTFLIRPVEQSDAESWERLRNLLWEGDDHKSEITQFFNGEVEEPNEVLLAVTEENDAIAHIELSLRYDIDGLTGIKTGYIEGLFVEERHRAAGVVLKLLRAAEFWARDQGCLAFASDRDDRVIIYARYTGAPPNNSLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "ATGACATTCCTGATCCGACCCGTAGAACAAAGTGACGCTGAATCTTGGGAGCGCTTACGCAACCTTTTGTGGGAGGGCGACGACCACAAAAGCGAGATCACACAATTCTTCAACGGCGAAGTAGAAGAACCCAATGAAGTGTTGCTTGCCGTAACCGAAGAAAATGATGCAATAGCGCACATCGAGCTATCGTTGAGGTATGACATTGATGGCTTGACGGGCATCAAGACCGGTTACATCGAAGGCCTTTTTGTAGAGGAGCGGCACCGTGCCGCAGGTGTAGTCCTCAAGCTATTGCGAGCCGCAGAGTTCTGGGCAAGAGATCAAGGATGTCTGGCGTTTGCCTCAGACAGGGATGATCGTGTCATCATCTATGCTCGCTACACGGGAGCGCCACCTAACAATTCATTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 193, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|53|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "350", "model_id": "63", "ARO_accession": "3002546", "ARO_name": "AAC(6')-Ib", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.02013e-24, "max_identities": 38, "bit_score": 85.1149, "cvterm_id": "35915", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFEKQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTAACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAAGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|194|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(3)-Ib/AAC(6')-Ib''", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "600", "model_id": "209", "ARO_accession": "3002600", "ARO_name": "AAC(3)-Ib/AAC(6')-Ib''", "ARO_category": {"36461": {"category_aro_accession": "3000322", "category_aro_cvterm_id": "36461", "category_aro_name": "AAC(3)", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 3.", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.77985e-24, "max_identities": 41, "bit_score": 87.0409, "cvterm_id": "36752", "query": "TKLGITKYSI------VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "TKLG+ +  +      +TNSNDSVTLRLMTEHDLAMLYEW+NRSHIVEWWGGEEA", "sequence_from_db": "TKLGVREDVMHFDIDPLTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MSIIATVKIGPDEISAMRAVLDLFGKEFEDIPTYSDRQPTNEYLANLLHSETFIALAAFDRGTAIGGLAAYVLPKFEQARSEIYIYDLAVASSHRRLGVATALISHLKRVAVELGAYVIYVQADYGDDPAVALYTKLGVREDVMHFDIDPLTNSNDSVTLRLMTEHDLAMLYEWVNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGGGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAGCATCATTGCAACCGTCAAGATCGGCCCTGACGAAATTTCAGCCATGAGGGCTGTGCTCGATCTCTTCGGCAAAGAGTTTGAGGACATTCCAACCTACTCTGATCGCCAGCCGACCAATGAGTATCTTGCCAATCTTCTGCACAGCGAGACGTTCATCGCGCTCGCTGCTTTTGACCGCGGAACAGCAATAGGTGGGCTCGCAGCCTACGTTCTACCCAAGTTCGAGCAAGCGCGAAGCGAGATCTACATTTATGACTTGGCAGTCGCTTCCAGCCATCGAAGGCTAGGAGTCGCAACTGCCCTGATTAGCCACCTGAAGCGTGTGGCGGTTGAACTTGGCGCGTATGTAATCTATGTGCAAGCAGACTACGGTGACGATCCGGCAGTCGCTCTCTACACAAAGCTTGGAGTTCGGGAAGACGTCATGCACTTCGACATTGATCCATTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGGTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAGGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 187, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 74.55}, "gnl|BL_ORD_ID|1702|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib11", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1801", "ARO_accession": "3002582", "ARO_name": "AAC(6')-Ib11", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 9.1424e-24, "max_identities": 39, "bit_score": 84.3445, "cvterm_id": "35732", "query": "KYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "K +I  NSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "KNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MKNTIHINSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDLSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGAAAAACACAATACATATCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCTGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 205, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 90.7}, "gnl|BL_ORD_ID|1001|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib3", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1068", "ARO_accession": "3002576", "ARO_name": "AAC(6')-Ib3", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.12083e-23, "max_identities": 38, "bit_score": 83.9593, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATTGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1162|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib'", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1235", "ARO_accession": "3003676", "ARO_name": "AAC(6')-Ib'", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33203e-23, "max_identities": 38, "bit_score": 83.9593, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGTTGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|945|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib4", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1002", "ARO_accession": "3002577", "ARO_name": "AAC(6')-Ib4", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.33203e-23, "max_identities": 38, "bit_score": 83.9593, "cvterm_id": "35507", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "+TNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "GTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 217, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 97.44, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|411|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib-Suzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "444", "ARO_accession": "3002591", "ARO_name": "AAC(6')-Ib-Suzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.41848e-16, "max_identities": 27, "bit_score": 64.3142, "cvterm_id": "36884", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRMDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTTACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCATGGATGCCTAA", "partial": "0", "query_start": 253, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|944|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ib-Hangzhou", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1000", "ARO_accession": "3002592", "ARO_name": "AAC(6')-Ib-Hangzhou", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.47733e-15, "max_identities": 26, "bit_score": 62.7734, "cvterm_id": "35507", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEEA", "match": "MTEHDL MLYEWLNRSHIVEWWGGEEA", "sequence_from_db": "MTEHDLVMLYEWLNRSHIVEWWGGEEA", "sequence_from_broadstreet": "MTEHDLVMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA", "dna_sequence_from_broadstreet": "ATGACTGAGCATGACCTTGTGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCACGCCCGACACTTGCTGACGTACAGGAACAGTACTTGCCAAGCGTTTTAGCGCAAGAGTCCGTCACTCCATACATTGCAATGCTGAATGGAGAGCCGATTGGGTATGCCCAGTCGTACGTTGCTCTTGGAAGCGGGGACGGATGGTGGGAAGAAGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCACTGGCGAATGCATCACAACTGGGCAAAGGCTTGGGAACCAAGCTGGTTCGAGCTCTGGTTGAGTTGCTGTTCAATGATCCCGAGGTCACCAAGATCCAAACGGACCCGTCGCCGAGCAACTTGCGAGCGATCCGATGCTACGAGAAAGCGGGGTTTGAGAGGCAAGGTACCGTAACCACCCCAGATGGTCCAGCCGTGTACATGGTTCAAACACGCCAGGCATTCGAGCGAACACGCAGTGATGCCTAA", "partial": "0", "query_start": 253, "query_end": 333, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 96.3, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|1481|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-32", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1577", "ARO_accession": "3002586", "ARO_name": "AAC(6')-32", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.00459e-15, "max_identities": 27, "bit_score": 62.003, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   VTLRLMTE DL ML+ WLNR HIVEWWGGEE", "sequence_from_db": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MSPSKTPVTLRLMTERDLPMLHAWLNRPHIVEWWGGEEERPTLHEVVKHYLPRVLAEEAVTPYIAMLGDEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQFLSNHTQLNQGLGTKLVQALVELLFSDPTVTKIQTDPAPNNHRAIRCYEKAGFVQQNVITTPDGPAVYMVQTRQAFERVRSAA", "dna_sequence_from_broadstreet": "ATGTCCCCGAGCAAAACACCCGTTACCTTGCGCCTCATGACCGAGCGCGACCTACCGATGCTGCATGCATGGCTGAACCGGCCGCACATTGTCGAGTGGTGGGGTGGAGAAGAAGAACGCCCGACTCTTCATGAAGTGGTCAAACACTACCTGCCGAGGGTTTTGGCAGAAGAAGCCGTCACACCATACATCGCGATGTTGGGCGACGAACCCATCGGCTACGCTCAGTCATACGTCGCACTCGGAAGCGGTGATGGATGGTGGGAGGATGAAACCGACCCAGGCGTACGAGGGATAGACCAATTCCTGTCGAACCATACACAGTTGAACCAGGGCCTAGGTACAAAGCTCGTCCAGGCACTCGTTGAACTGCTGTTCTCAGATCCTACCGTGACGAAGATCCAAACCGACCCGGCGCCAAACAACCATCGAGCGATTCGCTGCTACGAGAAAGCTGGCTTTGTTCAGCAAAACGTCATCACCACACCAGACGGCCCAGCCGTCTACATGGTTCAAACCAGGCAGGCCTTCGAGCGTGTGCGCAGTGCTGCCTAA", "partial": "0", "query_start": 217, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 71.05}, "gnl|BL_ORD_ID|1563|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-IIa", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "1657", "ARO_accession": "3002594", "ARO_name": "AAC(6')-IIa", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.44358e-15, "max_identities": 25, "bit_score": 61.6178, "cvterm_id": "35731", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ S   +TLRLMTE DL ML++WLNR HIVEWWGG+E", "sequence_from_db": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDE", "sequence_from_broadstreet": "MSASTPPITLRLMTERDLPMLHDWLNRPHIVEWWGGDEERPTLDEVLEHYLPRAMAEESVTPYIAMLGEEPIGYAQSYVALGSGDGWWEDETDPGVRGIDQSLADPTQLNKGLGTRLVRALVELLFSDPTVTKIQTDPTPNNHRAIRCYEKAGFVREKIITTPDGPAVYMVQTRQAFERKRGVA", "dna_sequence_from_broadstreet": "ATGTCCGCGAGCACCCCCCCCATAACTCTTCGCCTCATGACCGAGCGCGACCTGCCGATGCTCCATGATTGGCTCAACCGGCCGCACATCGTTGAGTGGTGGGGTGGTGACGAAGAGCGACCGACTCTTGATGAAGTGCTGGAACACTACCTGCCCAGAGCGATGGCGGAAGAGTCCGTAACACCGTACATCGCAATGCTGGGCGAGGAACCGATCGGCTATGCTCAGTCGTACGTCGCGCTCGGAAGCGGTGATGGCTGGTGGGAAGATGAAACTGATCCAGGAGTGCGAGGAATAGACCAGTCTCTGGCTGACCCGACACAGTTGAACAAAGGCCTAGGAACAAGGCTTGTCCGCGCTCTCGTTGAACTACTGTTCTCGGACCCCACCGTGACGAAGATTCAGACCGACCCGACTCCGAACAACCATCGAGCCATACGCTGCTATGAGAAGGCAGGATTCGTGCGGGAGAAGATCATCACCACGCCTGACGGGCCGGCGGTTTACATGGTTCAAACACGACAAGCCTTCGAGAGAAAGCGCGGTGTTGCCTAA", "partial": "0", "query_start": 217, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 65.79}, "gnl|BL_ORD_ID|125|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-IIb", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "140", "ARO_accession": "3002595", "ARO_name": "AAC(6')-IIb", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 4.04725e-14, "max_identities": 24, "bit_score": 59.3066, "cvterm_id": "36937", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGE", "match": "VTLR MTE D+ ML+EWLNR HIVEWWGGE", "sequence_from_db": "VTLRPMTEDDIGMLHEWLNRPHIVEWWGGE", "sequence_from_broadstreet": "MHPGVVTLRPMTEDDIGMLHEWLNRPHIVEWWGGERPSLEEVKEDYRPSALAEEGVTPYIGLLDGTPFAFAQSYVALGSGGGWWEEETDPGVRGIDQSIADSGLLGRGYGTRLVQALVDLLFADPQVSKVQTDPSPNNMRAIRCYEKAGFRKVKVVSTPDGPAMYMLHERPLVNGLRSAA", "dna_sequence_from_broadstreet": "ATGCATCCCGGCGTTGTTACTCTGCGTCCGATGACCGAAGACGACATCGGTATGCTTCACGAATGGTTGAATCGGCCGCACATTGTCGAATGGTGGGGTGGTGAGCGGCCCTCGCTCGAAGAGGTGAAAGAGGACTATCGGCCCAGCGCGTTGGCCGAAGAAGGAGTGACGCCGTACATCGGTTTGCTTGACGGAACTCCATTCGCGTTCGCACAGTCGTACGTTGCGCTCGGGTCGGGTGGTGGATGGTGGGAGGAAGAGACCGATCCTGGTGTCCGCGGAATCGATCAATCAATCGCCGATTCCGGGCTTCTCGGAAGAGGTTACGGCACTCGGCTGGTGCAGGCGCTTGTTGATTTGCTGTTCGCCGACCCGCAGGTATCCAAGGTTCAGACGGACCCCTCCCCGAACAACATGCGCGCGATACGCTGCTATGAGAAGGCAGGCTTCCGGAAGGTCAAGGTCGTTTCAACACCGGATGGGCCGGCCATGTACATGTTGCACGAGCGTCCGTTGGTGAACGGTTTGCGCAGTGCGGCCTAA", "partial": "0", "query_start": 238, "query_end": 327, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 80.0}, "gnl|BL_ORD_ID|1024|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-31", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "325", "model_id": "1093", "ARO_accession": "3002585", "ARO_name": "AAC(6')-31", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.02019e-13, "max_identities": 22, "bit_score": 56.6102, "cvterm_id": "36803", "query": "MTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "MTEHDL ML++WLNR HIVEWWGGEE", "sequence_from_db": "MTEHDLPMLHDWLNRPHIVEWWGGEE", "sequence_from_broadstreet": "MTEHDLPMLHDWLNRPHIVEWWGGEETRPTLAEVLEQYLPSALAKESVTPYIAMLDEEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLGKGLGTKLVCALVEMLFKDAEVTKIQTDPSPNNLRAIRCYEKAGFVAQRTINTPDGPAVYMVQTRQAFEQARSAV", "dna_sequence_from_broadstreet": "ATGACCGAGCACGACCTTCCGATGCTCCATGACTGGCTAAATCGGCCTCACATCGTTGAGTGGTGGGGCGGAGAAGAAACACGTCCAACACTTGCTGAAGTGCTGGAGCAATACCTACCAAGCGCCCTGGCGAAAGAGTCCGTCACTCCCTACATCGCAATGCTGGATGAAGAACCGATTGGGTACGCTCAGTCGTACATTGCACTCGGAAGCGGTGACGGATGGTGGGAAGACGAAACCGATCCAGGAGTACGCGGAATAGACCAGTCTCTGGCGAATCCATCGCAGCTGGGCAAGGGCTTGGGAACCAAGCTCGTTTGCGCGCTCGTTGAGATGCTGTTCAAAGACGCTGAGGTAACCAAGATCCAAACGGACCCGTCGCCGAACAACTTACGCGCAATCCGGTGCTACGAGAAGGCGGGTTTTGTGGCGCAAAGAACCATAAACACCCCAGATGGACCGGCCGTATACATGGTTCAAACACGTCAGGCGTTCGAGCAGGCGCGCAGTGCTGTCTAA", "partial": "0", "query_start": 253, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 84.62}, "gnl|BL_ORD_ID|687|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-IIc", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "730", "ARO_accession": "3002596", "ARO_name": "AAC(6')-IIc", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.87001e-13, "max_identities": 22, "bit_score": 56.6102, "cvterm_id": "36752", "query": "VTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "++ +N ++ LR+M E+DL ML+ WLNR HIVEWWGGE+", "sequence_from_db": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGED", "sequence_from_broadstreet": "MSANNAAIVLRVMAENDLPMLHAWLNRPHIVEWWGGEDERPTLDEVLEHYSPEVLAKQAVVPYIAMLDDEPIGYAQSYIALGSGDGWWEDETDPGVRGIDQSLANPSQLNKGLGTKLVRSLVELLFSDPAVTKIQTDPSPSNHRAIRCYEKAGFVQEKNILTPDGPAVYMVQTRQAFESLRTVQSFKIKGKWS", "dna_sequence_from_broadstreet": "ATGTCCGCCAACAATGCCGCAATAGTTCTACGAGTCATGGCCGAGAACGATCTGCCAATGCTCCATGCTTGGCTGAACCGCCCCCACATAGTCGAGTGGTGGGGCGGCGAGGATGAACGCCCAACTCTTGACGAAGTCTTAGAACACTATTCGCCCGAAGTTCTGGCAAAGCAAGCTGTAGTGCCTTACATCGCAATGCTAGATGACGAACCCATCGGCTACGCCCAATCCTACATCGCACTTGGAAGTGGCGATGGATGGTGGGAAGACGAAACTGATCCAGGGGTCCGCGGGATTGACCAGTCTTTGGCTAATCCATCACAGTTAAACAAGGGGTTGGGTACAAAGCTCGTACGCTCGCTCGTTGAACTCCTGTTTAGCGACCCGGCCGTAACGAAAATCCAAACCGATCCATCTCCTAGCAACCATCGCGCCATTCGCTGCTACGAGAAGGCCGGGTTCGTTCAAGAAAAAAACATCCTCACACCTGACGGCCCTGCGGTGTACATGGTCCAAACACGCCAGGCGTTCGAAAGCCTGCGCACTGTTCAAAGCTTCAAAATCAAGGGGAAGTGGTCATGA", "partial": "0", "query_start": 217, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 57.89}, "gnl|BL_ORD_ID|1714|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-Ie-APH(2'')-Ia", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "900", "model_id": "1814", "ARO_accession": "3002597", "ARO_name": "AAC(6')-Ie-APH(2'')-Ia", "ARO_category": {"36267": {"category_aro_accession": "3000128", "category_aro_cvterm_id": "36267", "category_aro_name": "APH(2'')", "category_aro_description": "Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 2''", "category_aro_class_name": "AMR Gene Family"}, "36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "40307": {"category_aro_accession": "3003675", "category_aro_cvterm_id": "40307", "category_aro_name": "plazomicin", "category_aro_description": "Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.035308, "max_identities": 7, "bit_score": 26.9498, "cvterm_id": "35508", "query": "DSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+ + +R + + D  ++ +WL    ++E++GG +", "sequence_from_db": "NEICIRTLIDDDFPLMLKWLTDERVLEFYGGRD", "sequence_from_broadstreet": "MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD", "dna_sequence_from_broadstreet": "ATGAATATAGTTGAAAATGAAATATGTATAAGAACTTTAATAGATGATGATTTTCCTTTGATGTTAAAATGGTTAACTGATGAAAGAGTATTAGAATTTTATGGTGGTAGAGATAAAAAATATACATTAGAATCATTAAAAAAACATTATACAGAGCCTTGGGAAGATGAAGTTTTTAGAGTAATTATTGAATATAACAATGTTCCTATTGGATATGGACAAATATATAAAATGTATGATGAGTTATATACTGATTATCATTATCCAAAAACTGATGAGATAGTCTATGGTATGGATCAATTTATAGGAGAGCCAAATTATTGGAGTAAAGGAATTGGTACAAGATATATTAAATTGATTTTTGAATTTTTGAAAAAAGAAAGAAATGCTAATGCAGTTATTTTAGACCCTCATAAAAATAATCCAAGAGCAATAAGGGCATACCAAAAATCTGGTTTTAGAATTATTGAAGATTTGCCAGAACATGAATTACACGAGGGCAAAAAAGAAGATTGTTATTTAATGGAATATAGATATGATGATAATGCCACAAATGTTAAGGCAATGAAATATTTAATTGAGCATTACTTTGATAATTTCAAAGTAGATAGTATTGAAATAATCGGTAGTGGTTATGATAGTGTGGCATATTTAGTTAATAATGAATACATTTTTAAAACAAAATTTAGTACTAATAAGAAAAAAGGTTATGCAAAAGAAAAAGCAATATATAATTTTTTAAATACAAATTTAGAAACTAATGTAAAAATTCCTAATATTGAATATTCGTATATTAGTGATGAATTATCTATACTAGGTTATAAAGAAATTAAAGGAACTTTTTTAACACCAGAAATTTATTCTACTATGTCAGAAGAAGAACAAAATTTGTTAAAACGAGATATTGCCAGTTTTTTAAGACAAATGCACGGTTTAGATTATACAGATATTAGTGAATGTACTATTGATAATAAACAAAATGTATTAGAAGAGTATATATTGTTGCGTGAAACTATTTATAATGATTTAACTGATATAGAAAAAGATTATATAGAAAGTTTTATGGAAAGACTAAATGCAACAACAGTTTTTGAGGGTAAAAAGTGTTTATGCCATAATGATTTTAGTTGTAATCATCTATTGTTAGATGGCAATAATAGATTAACTGGAATAATTGATTTTGGAGATTCTGGAATTATAGATGAATATTGTGATTTTATATACTTACTTGAAGATAGTGAAGAAGAAATAGGAACAAATTTTGGAGAAGATATATTAAGAATGTATGGAAATATAGATATTGAGAAAGCAAAAGAATATCAAGATATAGTTGAAGAATATTATCCTATTGAAACTATTGTTTATGGAATTAAAAATATTAAACAGGAATTTATCGAAAATGGTAGAAAAGAAATTTATAAAAGGACTTATAAAGATTGA", "partial": "0", "query_start": 232, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 21.21}, "gnl|BL_ORD_ID|1199|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "ErmT", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1275", "ARO_accession": "3000595", "ARO_name": "ErmT", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35946": {"category_aro_accession": "0000027", "category_aro_cvterm_id": "35946", "category_aro_name": "roxithromycin", "category_aro_description": "Roxithromycin is a semi-synthetic, 14-carbon ring macrolide antibiotic derived from erythromycin. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35964": {"category_aro_accession": "0000046", "category_aro_cvterm_id": "35964", "category_aro_name": "lincomycin", "category_aro_description": "Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction.", "category_aro_class_name": "Antibiotic"}, "35974": {"category_aro_accession": "0000057", "category_aro_cvterm_id": "35974", "category_aro_name": "telithromycin", "category_aro_description": "Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35982": {"category_aro_accession": "0000065", "category_aro_cvterm_id": "35982", "category_aro_name": "clarithromycin", "category_aro_description": "Clarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections.", "category_aro_class_name": "Antibiotic"}, "35983": {"category_aro_accession": "0000066", "category_aro_cvterm_id": "35983", "category_aro_name": "clindamycin", "category_aro_description": "Clindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria.", "category_aro_class_name": "Antibiotic"}, "36284": {"category_aro_accession": "3000145", "category_aro_cvterm_id": "36284", "category_aro_name": "tylosin", "category_aro_description": "Tylosin is a 16-membered macrolide, naturally produced by Streptomyces fradiae. It interacts with the bacterial ribosome 50S subunit to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36295": {"category_aro_accession": "3000156", "category_aro_cvterm_id": "36295", "category_aro_name": "spiramycin", "category_aro_description": "Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36297": {"category_aro_accession": "3000158", "category_aro_cvterm_id": "36297", "category_aro_name": "azithromycin", "category_aro_description": "Azithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.", "category_aro_class_name": "Antibiotic"}, "36315": {"category_aro_accession": "3000176", "category_aro_cvterm_id": "36315", "category_aro_name": "dirithromycin", "category_aro_description": "Dirithromycin is an oxazine derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome to inhibit bacterial protein synthesis.", "category_aro_class_name": "Antibiotic"}, "36722": {"category_aro_accession": "3000583", "category_aro_cvterm_id": "36722", "category_aro_name": "pristinamycin IA", "category_aro_description": "Pristinamycin 1A is a type B streptogramin antibiotic produced by Streptomyces pristinaespiralis. It binds to the P site of the 50S subunit of the bacterial ribosome, preventing the extension of protein chains.", "category_aro_class_name": "Antibiotic"}, "36723": {"category_aro_accession": "3000584", "category_aro_cvterm_id": "36723", "category_aro_name": "quinupristin", "category_aro_description": "Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis.", "category_aro_class_name": "Antibiotic"}, "37013": {"category_aro_accession": "3000669", "category_aro_cvterm_id": "37013", "category_aro_name": "pristinamycin IIA", "category_aro_description": "Pristinamycin IIA is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37016": {"category_aro_accession": "3000672", "category_aro_cvterm_id": "37016", "category_aro_name": "madumycin II", "category_aro_description": "Madumycin II is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37017": {"category_aro_accession": "3000673", "category_aro_cvterm_id": "37017", "category_aro_name": "griseoviridin", "category_aro_description": "Griseoviridin is a streptogramin A antibiotic.", "category_aro_class_name": "Antibiotic"}, "37018": {"category_aro_accession": "3000674", "category_aro_cvterm_id": "37018", "category_aro_name": "dalfopristin", "category_aro_description": "Dalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.", "category_aro_class_name": "Antibiotic"}, "37019": {"category_aro_accession": "3000675", "category_aro_cvterm_id": "37019", "category_aro_name": "pristinamycin IB", "category_aro_description": "Pristinamycin IB is a class B streptogramin similar to pristinamycin IA, the former containing a N-methyl-4-(methylamino)phenylalanine instead of a N-methyl-4-(dimethylamino)phenylalanine in its class A streptogramin counterpart (one less methyl group).", "category_aro_class_name": "Antibiotic"}, "37021": {"category_aro_accession": "3000677", "category_aro_cvterm_id": "37021", "category_aro_name": "virginiamycin S2", "category_aro_description": "Virginiamycin S2 is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37022": {"category_aro_accession": "3000678", "category_aro_cvterm_id": "37022", "category_aro_name": "vernamycin B-gamma", "category_aro_description": "Vernamycin B-gamma is a class B streptogramin derived from virginiamycin S1.", "category_aro_class_name": "Antibiotic"}, "37023": {"category_aro_accession": "3000679", "category_aro_cvterm_id": "37023", "category_aro_name": "vernamycin C", "category_aro_description": "Vernamycin C is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37024": {"category_aro_accession": "3000680", "category_aro_cvterm_id": "37024", "category_aro_name": "patricin A", "category_aro_description": "Patricin A is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37025": {"category_aro_accession": "3000681", "category_aro_cvterm_id": "37025", "category_aro_name": "patricin B", "category_aro_description": "Patricin B is a streptogramin B antibiotic.", "category_aro_class_name": "Antibiotic"}, "37026": {"category_aro_accession": "3000682", "category_aro_cvterm_id": "37026", "category_aro_name": "ostreogrycin B3", "category_aro_description": "Ostreogrycin B3 is a derivative of pristinamycin IA, with an additional 3-hydroxy group on its 4-oxopipecolic acid.", "category_aro_class_name": "Antibiotic"}, "37247": {"category_aro_accession": "3000867", "category_aro_cvterm_id": "37247", "category_aro_name": "oleandomycin", "category_aro_description": "Oleandomycin is a 14-membered macrolide produced by Streptomyces antibioticus. It is ssimilar to erythromycin, and contains a desosamine amino sugar and an oleandrose sugar. It targets the 50S ribosomal subunit to prevent protein synthesis.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.643841, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "36841", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALFLMTEVDISIL", "sequence_from_broadstreet": "MNKKNIKDSQNFITSKHHINEILRNVHLNTNDNIIEIGSGKGHFSFELAKRCNYVTAIEIDPKLCRITKNKLIEYENFQVINKDILQFKFPKNKSYKIFGNIPYNISTDIIRKIVFESTATESYLIVEYGFAKRLLNTNRSLALFLMTEVDISILSKIPREYFHPKPRVNSSLIVLKRHPSKISLKDRKQYENFVMKWVNKEYIKLFSKNQFYQALKYARIDDLNNISFEQFLSLFNSYKLFNR", "dna_sequence_from_broadstreet": "ATGAACAAAAAAAATATAAAAGATAGTCAAAACTTTATTACTTCAAAGCATCATATAAATGAAATTTTGAGAAATGTACATTTAAATACAAATGATAATATTATTGAGATTGGTTCAGGGAAAGGTCATTTCTCGTTTGAATTAGCTAAAAGGTGTAATTATGTAACCGCCATTGAAATAGATCCTAAATTATGTAGGATAACTAAAAACAAACTTATTGAATATGAGAACTTCCAGGTTATCAATAAAGATATTTTACAATTTAAGTTTCCTAAAAATAAGTCATATAAGATATTTGGAAATATACCCTACAATATAAGTACAGATATAATTCGAAAAATTGTTTTTGAAAGCACAGCTACAGAAAGTTATTTAATAGTGGAATATGGATTTGCTAAAAGGTTGCTAAATACAAATCGTTCACTAGCACTATTTTTAATGACAGAAGTTGATATATCCATATTAAGTAAAATCCCTAGAGAATACTTTCATCCAAAACCTAGAGTTAATAGCTCGTTAATTGTATTAAAAAGACACCCTTCAAAAATATCACTCAAAGATAGAAAACAATATGAAAATTTTGTTATGAAATGGGTTAACAAAGAATACATAAAACTATTTTCCAAAAACCAATTTTATCAAGCCTTAAAATATGCAAGAATTGACGATTTAAACAATATTAGCTTTGAACAATTCTTGTCTCTTTTCAATAGCTATAAATTATTTAATAGATAA", "partial": "0", "query_start": 223, "query_end": 279, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|1698|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "ErmY", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "400", "model_id": "1797", "ARO_accession": "3002825", "ARO_name": "ErmY", "ARO_category": {"36699": {"category_aro_accession": "3000560", "category_aro_cvterm_id": "36699", "category_aro_name": "Erm 23S ribosomal RNA methyltransferase", "category_aro_description": "Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.", "category_aro_class_name": "AMR Gene Family"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.683681, "max_identities": 10, "bit_score": 23.483, "cvterm_id": "35508", "query": "NSNDSVTLRLMTEHDLAML", "match": "N+N S+ L LMTE D+++L", "sequence_from_db": "NTNRSLALLLMTEVDISIL", "sequence_from_broadstreet": "MNKKDIKFSQNFITSKRHINKIMSNLELNRNDNVFEIGSGKGHFTLELVQKCNYVTVIEIDSNLCIQTQNKVTNYDNFRIINKDILQFKFPNNKAYKIYGNIPYYISTDIVRKIVFESEATVSYLIVEEGFAKRLLNTNRSLALLLMTEVDISILSKIPKEYFHPKPKINSSLIILKRHPSKISYKDKKMYNNFVMKWVNQEYSKLFTKNQFNKALNYAKIKDLKNINFEQFLSVFNSYKLFNN", "dna_sequence_from_broadstreet": "ATGAACAAAAAAGATATAAAATTTAGTCAAAATTTTATTACTTCGAAACGACATATAAATAAAATAATGAGTAATTTAGAATTAAATAGAAATGATAATGTTTTTGAAATTGGTTCAGGAAAAGGGCATTTCACACTAGAACTGGTTCAAAAATGTAATTATGTAACAGTTATCGAGATAGATTCAAATTTATGTATTCAAACACAAAATAAAGTTACAAATTACGATAACTTTCGAATTATAAATAAGGATATATTACAGTTTAAGTTCCCAAACAACAAAGCATATAAAATCTACGGTAATATACCTTATTATATAAGTACGGATATAGTACGAAAAATTGTCTTTGAAAGTGAAGCAACAGTTAGTTACTTAATAGTTGAAGAAGGATTTGCTAAAAGGCTACTCAATACAAATCGTTCTCTAGCGTTACTTTTAATGACTGAAGTAGATATATCCATATTAAGTAAAATCCCTAAAGAATACTTTCATCCAAAGCCTAAAATTAATAGCTCTTTAATTATATTAAAAAGACACCCGTCAAAAATATCATACAAAGATAAAAAAATGTATAATAATTTTGTTATGAAATGGGTTAACCAAGAATACAGCAAACTATTTACCAAAAATCAGTTTAATAAAGCCTTAAATTATGCAAAAATAAAGGATTTAAAGAACATTAACTTCGAACAATTTTTATCAGTATTTAATAGCTATAAATTGTTTAATAACTAA", "partial": "0", "query_start": 223, "query_end": 279, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 52.63}, "gnl|BL_ORD_ID|2301|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "AAC(6')-34", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "275", "model_id": "2525", "ARO_accession": "3003989", "ARO_name": "AAC(6')-34", "ARO_category": {"36484": {"category_aro_accession": "3000345", "category_aro_cvterm_id": "36484", "category_aro_name": "AAC(6')", "category_aro_description": "Acetylation of the aminoglycoside antibiotic on the amino group at position 6'.", "category_aro_class_name": "AMR Gene Family"}, "35924": {"category_aro_accession": "0000005", "category_aro_cvterm_id": "35924", "category_aro_name": "neomycin", "category_aro_description": "Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35926": {"category_aro_accession": "0000007", "category_aro_cvterm_id": "35926", "category_aro_name": "dibekacin", "category_aro_description": "Dibekacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Dibekacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35932": {"category_aro_accession": "0000013", "category_aro_cvterm_id": "35932", "category_aro_name": "amikacin", "category_aro_description": "Amikacin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35953": {"category_aro_accession": "0000035", "category_aro_cvterm_id": "35953", "category_aro_name": "sisomicin", "category_aro_description": "Sisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35956": {"category_aro_accession": "0000038", "category_aro_cvterm_id": "35956", "category_aro_name": "netilmicin", "category_aro_description": "Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.", "category_aro_class_name": "Antibiotic"}, "35966": {"category_aro_accession": "0000049", "category_aro_cvterm_id": "35966", "category_aro_name": "kanamycin A", "category_aro_description": "Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35969": {"category_aro_accession": "0000052", "category_aro_cvterm_id": "35969", "category_aro_name": "tobramycin", "category_aro_description": "Tobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "36996": {"category_aro_accession": "3000652", "category_aro_cvterm_id": "36996", "category_aro_name": "isepamicin", "category_aro_description": "A semi-synthetic derivative of gentamicin B (hydroxyamino propionyl genamicin B). It is modified to combat microbial inactivation and has a slightly larger spectrum of activity compared to other aminoglycosides, including Ser marcescens, Enterobacteria, and K pneumoniae.", "category_aro_class_name": "Antibiotic"}, "36998": {"category_aro_accession": "3000654", "category_aro_cvterm_id": "36998", "category_aro_name": "arbekacin", "category_aro_description": "A synthetic derivative (1-N-(4-amino-2-hydroxybutyryl) of dibekacin used in Japan. It is active against methicillin-resistant Staph. aureus and shows synergy with ampicillin when treating gentamicin and vancomycin resistant enterocci.", "category_aro_class_name": "Antibiotic"}, "36999": {"category_aro_accession": "3000655", "category_aro_cvterm_id": "36999", "category_aro_name": "gentamicin B", "category_aro_description": "Gentamicin B is a semisynthetic aminoglycoside antibacterial.", "category_aro_class_name": "Antibiotic"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "36000": {"category_aro_accession": "0001004", "category_aro_cvterm_id": "36000", "category_aro_name": "antibiotic inactivation", "category_aro_description": "Enzymatic inactivation of antibiotic to confer drug resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.07752, "max_identities": 8, "bit_score": 22.7126, "cvterm_id": "40862", "query": "VTLRLMTEHDLAMLYEWLNRSHIVEWWGGEE", "match": "+T+R + E D   L  WL+   +++++ G +", "sequence_from_db": "ITVRELEEKDEISLASWLSNPDVLQYYEGRD", "sequence_from_broadstreet": "MRIGDLIREDGGIAMLVYEAGPITVRELEEKDEISLASWLSNPDVLQYYEGRDNPHDVERVREHFYVDDDETRCIIKYEGKPIGYIQFYLLDEETLGEYGYNESDADCRTFATDQFIGEPDYWNRGIGTKLMTSMVEYLVFQRQADRIVMDPQAWNERAIACYEKCGFRKVRLLEKHEQHEGELRDCWIMEYRAERK", "dna_sequence_from_broadstreet": "ATGAGAATTGGGGATCTAATAAGGGAAGATGGGGGGATCGCGATGCTGGTGTACGAGGCTGGACCGATTACGGTTCGCGAGCTGGAGGAGAAGGATGAAATATCCTTAGCTTCTTGGCTGTCCAATCCGGATGTGCTGCAGTATTATGAGGGACGGGACAATCCTCACGACGTGGAGCGGGTGCGGGAGCATTTTTACGTGGATGATGATGAGACTCGCTGCATCATTAAATATGAGGGGAAACCGATCGGATATATTCAGTTTTATCTTCTGGATGAAGAGACGTTAGGCGAGTATGGATATAACGAGAGTGATGCAGACTGCAGAACCTTCGCCACGGATCAATTCATCGGGGAGCCGGATTATTGGAATCGAGGCATCGGTACGAAGCTCATGACTTCCATGGTGGAGTATCTCGTGTTTCAGAGGCAGGCTGATCGGATCGTAATGGACCCGCAGGCATGGAATGAACGGGCGATTGCTTGTTACGAAAAGTGCGGCTTCCGGAAGGTCAGACTGCTGGAGAAGCATGAACAGCATGAAGGTGAACTGCGGGACTGCTGGATTATGGAGTATCGGGCAGAGCGAAAGTAA", "partial": "0", "query_start": 238, "query_end": 330, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 25.81}, "gnl|BL_ORD_ID|2493|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "Nocardia rifampin resistant beta-subunit of RNA polymerase (rpoB2)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "2200", "model_id": "2831", "ARO_accession": "3000501", "ARO_name": "rpoB2", "ARO_category": {"36349": {"category_aro_accession": "3000210", "category_aro_cvterm_id": "36349", "category_aro_name": "rifamycin-resistant beta-subunit of RNA polymerase (rpoB)", "category_aro_description": "Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin.", "category_aro_class_name": "AMR Gene Family"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36656": {"category_aro_accession": "3000517", "category_aro_cvterm_id": "36656", "category_aro_name": "rifaximin", "category_aro_description": "Rifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase.", "category_aro_class_name": "Antibiotic"}, "36669": {"category_aro_accession": "3000530", "category_aro_cvterm_id": "36669", "category_aro_name": "rifabutin", "category_aro_description": "Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis.", "category_aro_class_name": "Antibiotic"}, "36673": {"category_aro_accession": "3000534", "category_aro_cvterm_id": "36673", "category_aro_name": "rifapentine", "category_aro_description": "Rifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy.", "category_aro_class_name": "Antibiotic"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "35998": {"category_aro_accession": "0001002", "category_aro_cvterm_id": "35998", "category_aro_name": "antibiotic target replacement", "category_aro_description": "Replacement or substitution of antibiotic action target, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 1.11689, "max_identities": 10, "bit_score": 22.7126, "cvterm_id": "41346", "query": "RLMTEHDLAMLYEWLNRSHIVE", "match": "R++TE D+A   E+L R H  E", "sequence_from_db": "RVLTEDDIAATIEYLVRLHAGE", "sequence_from_broadstreet": "MLEGRIVTVSSRTESPLAAPGVPGAPRRLSFARIREPLAVPGLLDIQTESFGWLIGAPDWCARAAARGTEPVAGLAEVLAEISPIEDFAGTMSLTLSDPRFEEVKASVEECKDKDLTYAAPWFVTAEFVNNNTGEIKSQTVFMGDFPMMTAHGTFVVNGTERVVVSQLVRSPGVYFDHAIDKGSEKDVHSARVIPSRGAWLEFDVDKRDTLGVRIDRKRRQPVTVLLKALGWSAERIAERFGFAPLIMASLAKDNVAGTDDALLEIHRKLRPGEPPTKESAQNLLANLFFTEKRYDLARVGRYKIDKKLGLRAPGAPRVLTEDDIAATIEYLVRLHAGERTMIAPGGVEVPVEVDDIDHFGNRRVRTVGELIQNQIRVGLSRMERVVRERMTTQDVEAITPQSLMNIRPVVAAMKEFFGTSQLSQFMDQRNPLASLTNKRRLSALGPGGLSRERAGLEVRDVHYSHYGRMCPIETPEGPNIGLMGYLSVYARVNPFGFVETPYRRVVDGRVTDEVDYLTADEEDRHVVAQANEPLDAEGRFLAARIPVRRKNSEVELVDSAAVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLIRSEAPIVGTGMELRAAVDAGDVVVNEKAGVVEEVSADYVTVMADDGTRKSYRMRKFNRSNQGTCSNQRPIVDEGQRVEAGQVLADGPCTENGEMALGKNLLVAIMPWEGHNYEDAIILSQRLVEQDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDDLPPGVNELVRVYVAQKRKIQDGDKLAGRHGNKGVIGKILPTEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWIGKAGWKVEGNPEWAKDLPEEMWEAPADSNIATPVFDGAREEELTGLLGSTLPNRDGERMVDDNGKAVLFDGRSGEPFPYPVAVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGDNIPEPGVPESFKVLLKELQALCLNVEVLSAGAAVELAHGVDDDHERTAANLGINLSRAESITETELSG", "dna_sequence_from_broadstreet": "GTGCTGGAAGGACGCATCGTGACAGTCTCGAGTCGGACCGAGTCCCCGCTCGCCGCGCCCGGAGTCCCGGGTGCGCCCCGGCGGCTCTCGTTCGCCAGAATCCGCGAGCCCCTGGCGGTTCCGGGCCTGCTGGACATTCAGACCGAATCGTTCGGGTGGCTGATCGGCGCACCCGACTGGTGCGCCCGCGCGGCAGCCCGCGGGACGGAACCGGTCGCCGGGCTGGCCGAGGTGCTCGCCGAGATCAGCCCCATCGAGGACTTCGCGGGCACGATGTCGCTGACGTTGTCCGATCCGCGGTTCGAGGAGGTCAAGGCCTCCGTCGAGGAGTGCAAGGACAAGGATCTGACCTATGCCGCGCCGTGGTTCGTCACGGCGGAATTCGTGAACAACAACACCGGCGAGATCAAGAGCCAGACCGTTTTCATGGGTGATTTCCCCATGATGACCGCGCACGGGACATTCGTCGTCAACGGCACCGAACGGGTGGTCGTGTCGCAACTGGTGCGCTCGCCGGGCGTGTACTTCGACCACGCGATCGACAAGGGTTCGGAGAAGGACGTGCACAGCGCGCGGGTGATCCCGTCGCGCGGTGCCTGGCTGGAGTTCGACGTCGACAAGCGCGACACCCTGGGCGTGCGCATCGACCGCAAGCGCCGTCAGCCGGTAACGGTGCTGCTCAAGGCGCTGGGCTGGAGTGCGGAGCGAATCGCCGAGCGATTCGGGTTCGCCCCGCTGATCATGGCCTCGCTGGCCAAGGACAACGTGGCGGGCACCGACGACGCTTTGCTCGAGATCCATCGCAAGCTGCGTCCGGGCGAGCCGCCGACCAAGGAGTCGGCACAGAACCTGCTGGCAAATCTGTTCTTCACCGAGAAGCGCTACGACCTGGCGCGGGTGGGCCGTTACAAGATCGACAAGAAGCTCGGGCTGCGCGCTCCGGGGGCACCGCGGGTGCTCACCGAGGACGACATCGCGGCCACCATCGAGTACCTGGTGCGCCTGCACGCCGGGGAGAGGACGATGATCGCGCCCGGCGGGGTCGAGGTGCCGGTGGAGGTCGACGACATCGACCATTTCGGTAACCGCCGGGTGCGCACCGTGGGTGAGCTGATCCAGAACCAGATCCGCGTGGGTCTGTCCCGGATGGAACGGGTGGTGCGGGAGCGCATGACCACCCAGGACGTCGAGGCGATCACGCCGCAGTCGCTGATGAACATCCGCCCGGTGGTCGCGGCGATGAAGGAGTTCTTCGGCACCTCGCAGCTGTCGCAGTTCATGGACCAGCGCAACCCGCTGGCGAGCCTGACCAACAAGCGGCGGCTGTCCGCGCTCGGGCCGGGCGGGCTCTCGCGCGAACGGGCCGGCTTGGAGGTCCGCGACGTGCACTACAGCCACTACGGCCGGATGTGCCCGATCGAGACGCCGGAGGGGCCGAACATCGGCCTGATGGGGTACCTGTCGGTGTACGCGCGGGTCAACCCGTTCGGTTTCGTCGAGACCCCCTACCGGCGGGTGGTGGACGGCCGGGTCACCGACGAGGTCGATTACCTCACCGCCGACGAGGAGGACCGGCACGTGGTGGCCCAGGCGAACGAACCGCTGGACGCCGAGGGCCGCTTCCTGGCCGCGCGAATCCCGGTGCGCCGGAAGAACTCCGAGGTGGAACTCGTCGATTCCGCCGCGGTGGATTACATGGATGTGTCGCCGCGGCAGATGGTGTCGGTGGCGACGGCGATGATTCCGTTCCTCGAGCATGATGATGCCAACCGTGCGCTGATGGGTGCGAATATGCAGCGTCAGGCGGTGCCGTTGATTCGGTCGGAGGCGCCGATCGTGGGTACCGGTATGGAGCTGCGTGCGGCGGTGGATGCCGGTGATGTGGTGGTGAACGAGAAGGCCGGTGTGGTCGAGGAGGTTTCGGCCGATTACGTCACGGTGATGGCCGATGACGGGACTCGTAAGTCGTATCGGATGCGGAAGTTCAACCGGTCGAATCAGGGGACGTGTTCGAATCAGCGGCCGATCGTGGACGAGGGTCAGCGGGTCGAGGCCGGGCAGGTGTTGGCTGATGGGCCGTGCACCGAGAACGGTGAGATGGCGCTGGGTAAGAACCTGTTGGTGGCGATCATGCCGTGGGAGGGGCACAACTACGAGGACGCGATCATCCTGTCGCAGCGGTTGGTGGAGCAGGATGTGTTGACCTCGATCCATATCGAGGAGCACGAGATCGATGCTCGTGACACCAAGCTCGGTGCCGAGGAGATCACTCGCGACATTCCGAATGTCTCCGATGAGGTGTTGGCGGATCTGGACGAGCGTGGCATCGTGCGGATCGGTGCGGAGGTGCGTGATGGTGACATCCTGGTCGGTAAGGTCACGCCCAAGGGTGAGACCGAGCTGACGCCGGAGGAGCGGTTGCTGCGGGCGATCTTCGGGGAGAAGGCGCGTGAGGTGCGTGATACCTCGTTGAAGGTGCCCCACGGTGAGTCGGGCAAGGTCATCGGGATCCGGGTGTTCTCTCGGGAGGACGATGACGATCTGCCGCCCGGTGTCAACGAGTTGGTGCGGGTGTATGTGGCGCAGAAGCGCAAGATCCAAGACGGTGACAAGCTGGCCGGTCGGCACGGGAACAAGGGTGTGATCGGCAAGATCCTGCCCACCGAGGACATGCCGTTCCTGCCCGATGGCACCCCGGTCGACATCATCCTCAACACCCACGGTGTGCCGCGGCGTATGAACATCGGCCAGATCCTGGAAACCCACCTCGGCTGGATCGGCAAAGCCGGCTGGAAGGTCGAGGGCAACCCCGAGTGGGCCAAGGATCTGCCGGAGGAGATGTGGGAGGCCCCCGCGGACTCCAACATCGCGACTCCGGTGTTCGACGGTGCCCGCGAGGAGGAGCTGACGGGTCTGCTGGGCTCGACGCTGCCCAACCGTGACGGTGAGCGGATGGTCGACGACAACGGCAAGGCCGTGCTGTTCGACGGTCGTTCCGGTGAGCCGTTCCCGTACCCGGTGGCGGTGGGCTACATGTACATCCTGAAGCTGCACCACCTGGTCGACGACAAGATCCACGCTCGCTCCACCGGCCCGTACTCGATGATCACCCAGCAGCCGCTCGGTGGTAAGGCCCAGTTCGGTGGCCAGCGCTTCGGTGAGATGGAGTGCTGGGCGATGCAGGCCTACGGCGCGGCCTACACCCTGCAGGAACTGCTCACGATCAAGTCCGACGACGTCGTCGGCCGCGTGAAGGTCTACGAGGCGATCGTCAAGGGCGACAACATCCCGGAACCCGGTGTGCCGGAATCGTTCAAGGTGTTGTTGAAGGAACTCCAGGCACTGTGCCTCAACGTCGAGGTGCTGTCCGCCGGTGCCGCGGTCGAACTGGCGCACGGGGTCGACGACGATCACGAGCGGACGGCCGCGAACCTCGGCATCAACCTGTCCCGCGCCGAATCCATCACGGAGACCGAGCTGTCCGGGTGA", "partial": "0", "query_start": 247, "query_end": 312, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 45.45}, "gnl|BL_ORD_ID|1219|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "otr(A)", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1200", "model_id": "1273", "ARO_accession": "3002891", "ARO_name": "otr(A)", "ARO_category": {"35921": {"category_aro_accession": "0000002", "category_aro_cvterm_id": "35921", "category_aro_name": "tetracycline-resistant ribosomal protection protein", "category_aro_description": "A family of proteins known to bind to the 30S ribosomal subunit. This interaction prevents tetracycline and tetracycline derivatives from inhibiting ribosomal function. Thus, these proteins confer elevated resistance to tetracycline derivatives as a ribosomal protection protein.", "category_aro_class_name": "AMR Gene Family"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.44126, "max_identities": 7, "bit_score": 21.557, "cvterm_id": "36773", "query": "LMTEHDLAMLYEWLNRSHIV", "match": "L+ +HD A L  +L+  H++", "sequence_from_db": "LLADHDDAFLTAYLDEEHVL", "sequence_from_broadstreet": "MNKLNLGILAHVDAGKTSLTERLLHRTGVIDEVGSVDAGTTTTDSMELERQRGITIRSAVATFVLDDLKVNLIDTPGHSDFISEVERALGVLDGAVLVVSAVEGVQPQTRILMRTLRRLGIPTLVFVNKIDRGGARPDGVLREIRDRLTPAAVALSAVADAGTPRARAIALGPDTDPDFAVRVGELLADHDDAFLTAYLDEEHVLTEKEYAEELAAQTARGLVHPVYFGSALTGEGLDHLVHGIRELLPSVHASQDAPLRATVFKVDRGARGEAVAYLRLVSGTLGTRDSVTLHRVDHTGRVTEHAGRITALRVFEHGSATSETRATAGDIAQAWGLKDVRVGDRAGHLDGPPPRNFFAPPSLETVIRPERPEEAGRLHAALRMLDEQDPSIDLRQDEENAAGAVVRLYGEVQKEILGSTLAESFGVRVRFDPTRTVCIEKPVGTGEALIELDTRTHNYFWGAPWVCASDRPSPARAITFRLAVELGSLPLAFHKAIEETVHTTLRHGLYGWQVTDCAVTLTRTGVRSPVSAADDFRKANARLVLMDALGRAGTEVHEPVSSFELEVPAARLSPVLAKLAELGATPGVPTAEGDVFRLEGTMPTSLVHDFNQRVPGLTQGEGVFLAEHRGYRPAVGQPPVRPRPEGPNPLNRDEYILHVLKRV", "dna_sequence_from_broadstreet": "ATGAACAAGCTGAATCTGGGCATCCTGGCCCACGTTGACGCCGGCAAGACCAGCCTCACCGAGCGCCTGCTGCACCGCACCGGTGTGATCGACGAGGTCGGCAGCGTGGACGCCGGCACCACGACGACCGACTCGATGGAGCTGGAGCGGCAGCGCGGCATCACCATCCGGTCCGCCGTGGCCACGTTCGTCCTGGACGATCTCAAGGTCAACCTCATCGACACCCCGGGCCACTCCGACTTCATCTCCGAGGTCGAGCGGGCGCTCGGGGTGCTCGACGGCGCGGTCCTGGTGGTCTCGGCCGTCGAGGGCGTCCAGCCGCAGACCCGCATCCTGATGCGGACCCTGCGCAGGCTGGGCATTCCCACGCTGGTCTTCGTCAACAAGATCGACCGGGGCGGCGCGCGTCCCGACGGTGTGCTGCGGGAGATCCGCGACCGGCTCACCCCCGCCGCGGTGGCACTGTCCGCCGTGGCGGACGCCGGCACGCCGCGGGCCCGCGCGATCGCGCTCGGCCCGGACACCGACCCGGACTTCGCCGTCCGGGTCGGTGAGCTGCTGGCCGACCACGACGACGCGTTCCTCACCGCCTACCTGGACGAGGAACACGTACTGACCGAGAAGGAGTACGCGGAGGAACTGGCCGCGCAGACCGCGCGCGGTCTGGTGCACCCGGTGTACTTCGGGTCCGCGCTGACCGGCGAGGGCCTGGACCATCTGGTGCACGGCATCCGGGAGTTGCTGCCGTCCGTGCACGCGTCGCAGGACGCGCCGCTGCGGGCCACCGTGTTCAAGGTGGACCGTGGCGCGCGCGGCGAGGCCGTCGCGTACCTGCGGCTGGTCTCCGGCACGCTGGGCACCCGCGATTCGGTGACGCTGCACCGCGTCGACCACACCGGCCGGGTCACCGAGCACGCCGGACGCATCACCGCGCTGCGGGTCTTCGAGCACGGGTCGGCCACCAGCGAGACCCGGGCGACCGCCGGGGACATCGCGCAGGCGTGGGGCCTGAAGGACGTACGGGTCGGTGACCGGGCCGGGCACCTCGACGGTCCCCCGCCGCGCAACTTCTTCGCGCCGCCCAGCCTGGAGACCGTGATCAGGCCGGAGCGCCCGGAGGAAGCGGGACGGCTGCACGCCGCGCTGCGCATGCTGGACGAGCAGGACCCCTCGATCGACCTGCGGCAGGACGAGGAGAACGCGGCCGGCGCGGTGGTCCGCCTCTACGGGGAGGTGCAGAAGGAGATCCTCGGCAGCACGCTCGCGGAGTCCTTCGGCGTACGGGTGCGCTTCGACCCGACCCGTACGGTCTGCATCGAAAAGCCCGTGGGGACCGGCGAGGCGCTGATCGAGCTGGACACGCGGACGCACAACTACTTCTGGGGCGCACCGTGGGTCTGCGCGTCGGACCGGCCGAGCCCGGCGCGGGCGATCACGTTCCGTTTGGCGGTGGAACTGGGCTCGCTCCCCCTGGCCTTCCACAAGGCCATCGAGGAGACGGTGCACACCACCCTGCGGCACGGTCTGTACGGCTGGCAGGTCACCGACTGCGCCGTCACCCTGACCCGTACCGGCGTTCGCAGTCCGGTCAGCGCGGCCGACGACTTCCGCAAGGCCAACGCGCGCTTGGTCCTGATGGACGCGCTCGGCAGGGCCGGTACGGAGGTGCACGAGCCGGTCAGCTCCTTCGAACTGGAGGTGCCCGCCGCCCGGCTCAGCCCGGTACTTGCGAAACTCGCGGAACTGGGCGCGACGCCCGGTGTGCCCACGGCCGAGGGGGACGTCTTCCGCCTGGAGGGCACGATGCCGACCAGCCTCGTGCACGACTTCAACCAGCGGGTTCCCGGACTGACCCAGGGCGAGGGCGTGTTCCTGGCCGAGCACCGGGGCTACCGGCCCGCCGTCGGACAGCCGCCCGTGCGGCCGCGGCCCGAGGGGCCCAACCCGCTCAACCGCGACGAGTACATCCTGCACGTGCTCAAGCGCGTGTGA", "partial": "0", "query_start": 250, "query_end": 309, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 35.0}, "gnl|BL_ORD_ID|2106|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "salA", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "1100", "model_id": "2265", "ARO_accession": "3003749", "ARO_name": "salA", "ARO_category": {"41687": {"category_aro_accession": "3004469", "category_aro_cvterm_id": "41687", "category_aro_name": "ABC-F ATP-binding cassette ribosomal protection protein", "category_aro_description": "A subfamily of the ATP-binding cassette protein superfamily. Unlike other ABC proteins, ABC-F genes are not fused to a transmembrane domain nor associated with transport. It has been shown that ABC-F proteins confer antibiotic resistance via ribosomal protection and not antibiotic efflux as in other ABC proteins.", "category_aro_class_name": "AMR Gene Family"}, "37716": {"category_aro_accession": "3001317", "category_aro_cvterm_id": "37716", "category_aro_name": "pleuromutilin", "category_aro_description": "Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35936": {"category_aro_accession": "0000017", "category_aro_cvterm_id": "35936", "category_aro_name": "lincosamide antibiotic", "category_aro_description": "Lincosamides (e.g. lincomycin, clindamycin) are a class of drugs which bind to the 23s portion of the 50S subunit of bacterial ribosomes. This interaction inhibits early elongation of peptide chains by inhibiting the transpeptidase reaction, acting similarly to macrolides.", "category_aro_class_name": "Drug Class"}, "35945": {"category_aro_accession": "0000026", "category_aro_cvterm_id": "35945", "category_aro_name": "streptogramin antibiotic", "category_aro_description": "Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36218": {"category_aro_accession": "3000079", "category_aro_cvterm_id": "36218", "category_aro_name": "oxazolidinone antibiotic", "category_aro_description": "Oxazolidinones are a class of synthetic antibiotics discovered the the 1980's.  They inhibit protein synthesis by binding to domain V of the 23S rRNA of the 50S subunit of bacterial ribosomes.  Linezolid is the only member of this class currently in clinical use.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37014": {"category_aro_accession": "3000670", "category_aro_cvterm_id": "37014", "category_aro_name": "pleuromutilin antibiotic", "category_aro_description": "Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes.", "category_aro_class_name": "Drug Class"}, "35999": {"category_aro_accession": "0001003", "category_aro_cvterm_id": "35999", "category_aro_name": "antibiotic target protection", "category_aro_description": "Protection of antibiotic action target from antibiotic binding, which process will result in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 3.63586, "max_identities": 8, "bit_score": 21.557, "cvterm_id": "40406", "query": "MTEHDLAMLYEWLNRSHIVE", "match": "M E DL   Y+W    +I+E", "sequence_from_db": "MMEQDLTPYYDWTVMDYIIE", "sequence_from_broadstreet": "MLFLFEEKALEVEHKVLIPELTFSIEDHEHLAIVGVNGVGKSTLLKVIHQDQSVDSAMMEQDLTPYYDWTVMDYIIESYPEIAKIRLQLNHTDMINKYIELDGYIIEGEIVTEAKKLGIKEEQLEQKISTLSGGEQTKVSFLKVKMSKASLLLIDEPTNHMDLEMKEWLTKAFKQEQRAILFVSHDRTFLNETPDAILELSLDGAKKYIGKYDKYKQQKDIEHETLKLQYEKQQKEQAAIEETIKKYKAWYQKAEQSASVRSPYQQKQLSKLAKRFKSKEQQLNRKLDQEHIPNPHKKEKTFSIQHHNFKSHYLVQFNHVSFAYDNRKIFDDVSFYIKRNQNVIVEGRNGTGKSTLIKLILGELEPTKGDITVHPELEIGYFSQDFENLNMHHTVLDEILEIPEMKEADARTILASFYFDKDRINDVVETLSMGEKCRLQFVKLYFSNPHIMILDEPTNYFDIGMQENIIQLIQSFQGSVLIVSHDNYFKSQIKDQTWTIKNHQMTHENVQVKDPINTESMKHHLKELEQYTDERNRETEF", "dna_sequence_from_broadstreet": "ATGCTATTTTTATTTGAAGAAAAAGCATTAGAAGTTGAACATAAAGTATTAATACCCGAGTTGACTTTTTCAATAGAGGACCATGAACATTTAGCAATCGTTGGTGTTAATGGTGTTGGAAAATCAACATTATTAAAAGTCATTCATCAAGATCAATCAGTTGATTCAGCGATGATGGAACAAGATTTAACACCTTATTATGATTGGACTGTTATGGATTATATAATTGAATCATATCCTGAAATCGCAAAGATTAGATTGCAACTTAATCATACAGATATGATTAATAAATATATTGAATTAGATGGATACATTATAGAAGGTGAAATCGTAACAGAAGCAAAAAAGCTCGGAATAAAAGAGGAACAACTAGAACAGAAAATTTCTACTTTAAGTGGTGGAGAACAAACAAAAGTATCATTTTTAAAAGTGAAAATGTCTAAAGCATCATTACTATTAATCGATGAACCAACAAACCACATGGATTTAGAAATGAAGGAATGGTTGACGAAAGCTTTTAAACAAGAACAACGTGCTATATTATTTGTATCTCATGACCGAACATTTTTAAATGAAACGCCAGATGCTATATTAGAATTGAGTCTTGATGGGGCTAAGAAGTATATCGGTAAATACGATAAATACAAACAACAAAAAGATATAGAGCATGAAACATTAAAGCTACAGTATGAAAAACAACAAAAAGAACAAGCGGCCATTGAAGAAACGATTAAAAAATATAAAGCATGGTATCAAAAAGCAGAACAAAGTGCTTCTGTGAGAAGCCCATATCAACAAAAACAATTAAGTAAGTTAGCGAAACGGTTTAAATCAAAAGAACAACAATTAAATCGTAAACTTGATCAAGAGCATATCCCAAATCCACATAAAAAAGAGAAAACTTTCTCAATACAACATCATAATTTTAAATCACATTATTTAGTTCAATTTAATCATGTTTCGTTTGCTTATGATAACCGGAAAATATTCGATGATGTATCATTCTATATTAAGCGAAATCAAAATGTTATTGTTGAAGGCAGAAATGGTACAGGTAAATCAACTTTAATCAAATTGATACTCGGTGAACTCGAGCCAACTAAAGGTGATATAACTGTTCATCCAGAATTAGAAATTGGATATTTCTCTCAAGATTTTGAGAATTTAAATATGCATCATACTGTCTTAGATGAAATATTAGAAATTCCTGAAATGAAAGAAGCAGATGCAAGAACCATATTAGCAAGCTTTTATTTTGATAAAGATAGGATAAATGATGTTGTTGAAACACTATCGATGGGTGAAAAATGTAGGTTACAATTTGTAAAATTATATTTTTCAAATCCTCATATTATGATATTAGATGAGCCAACAAACTATTTCGATATTGGCATGCAAGAAAATATCATTCAATTAATACAATCATTTCAAGGTTCGGTCCTTATTGTATCTCATGATAATTATTTTAAATCACAAATTAAAGATCAGACTTGGACTATAAAAAATCATCAAATGACGCATGAAAATGTTCAAGTCAAAGATCCTATTAATACAGAATCTATGAAACATCATTTAAAAGAATTAGAACAATATACAGATGAAAGAAATCGTGAAACAGAGTTCTAG", "partial": "0", "query_start": 253, "query_end": 312, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 40.0}, "gnl|BL_ORD_ID|2095|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.48609, "max_identities": 9, "bit_score": 20.4014, "cvterm_id": "42594", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 238, "query_end": 291, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}, "gnl|BL_ORD_ID|2094|hsp_num:0": {"type_match": "Loose", "orf_strand": "+", "orf_start": 172, "orf_end": 333, "orf_from": "NODE_185_length_335_cov_33.8077_1 ", "model_name": "vanKI", "model_type": "protein homolog model", "model_type_id": 40292, "pass_evalue": "n/a", "pass_bitscore": "700", "model_id": "2245", "ARO_accession": "3003727", "ARO_name": "vanKI", "ARO_category": {"36373": {"category_aro_accession": "3000234", "category_aro_cvterm_id": "36373", "category_aro_name": "glycopeptide resistance gene cluster", "category_aro_description": "Genes that when expressed confer resistance to vancomycin and teicoplanin type antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "39349": {"category_aro_accession": "3002915", "category_aro_cvterm_id": "39349", "category_aro_name": "vanK", "category_aro_description": "VanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance", "category_aro_class_name": "AMR Gene Family"}, "36220": {"category_aro_accession": "3000081", "category_aro_cvterm_id": "36220", "category_aro_name": "glycopeptide antibiotic", "category_aro_description": "Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria.  This inhibits transglycosylation leading to cell death due to osmotic stress.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 7.48609, "max_identities": 9, "bit_score": 20.4014, "cvterm_id": "40382", "query": "VTLRLMTEHDLAMLYEWL", "match": "V +R+ TE DL   YE L", "sequence_from_db": "VKVRVGTEQDLPAFYELL", "sequence_from_broadstreet": "MLNVDKISEETYYAFISQADLGNFMQYPSWAKVKTEWTSDLLGWFTPDNKLAGCGLILYRKMPCLNRYLAYCPRGPLIDWQSPNLREWFEPLVAYLRSKQVFSIKIDPPVVQAKWSAPTIKTFLGQAREQGSKGKVLRDLPPDEDYTTVQQVQQQLRQMGWRKQRGDTGFAATQPQYVYRLPLEGRSLEEVFAGFHTNWRRNVKKAERLGVKVRVGTEQDLPAFYELLKVTSERDHFKVRSFSYFSNLYRSLKAEAADRIALYLAEDEEELLAATLAVHSNAHSWYLYGASSNVKREKAPNHAIQWRMIQDAYQLKAYTYDFRGISPTLDESDPLFGLLRFKLGFGGEACEMISAWDYPLQPLLYRAFQLYLKRR", "dna_sequence_from_broadstreet": "ATGTTAAACGTTGACAAGATAAGTGAAGAAACCTATTATGCGTTCATTTCTCAAGCGGATCTAGGCAATTTTATGCAGTATCCTTCCTGGGCCAAGGTCAAAACTGAGTGGACCAGCGATTTATTGGGGTGGTTCACCCCGGACAATAAATTGGCAGGGTGTGGTTTGATCTTATACCGGAAAATGCCCTGCCTTAACCGGTACCTGGCGTATTGTCCCCGCGGTCCCCTTATTGACTGGCAGAGCCCCAACCTCAGGGAATGGTTCGAACCTCTTGTGGCTTATTTGAGAAGCAAGCAGGTTTTCAGTATCAAGATCGATCCTCCGGTGGTCCAGGCAAAATGGTCTGCCCCCACCATTAAAACGTTTTTAGGGCAAGCCCGTGAACAGGGCAGCAAAGGGAAAGTTTTGCGCGATTTGCCGCCGGACGAAGACTACACAACGGTCCAACAAGTGCAGCAGCAATTACGGCAAATGGGTTGGCGGAAGCAGCGGGGGGATACGGGTTTCGCTGCGACCCAGCCCCAATATGTTTACCGCCTGCCCTTAGAGGGGCGCAGCCTGGAGGAGGTCTTCGCCGGTTTTCATACCAACTGGAGGCGCAATGTTAAAAAGGCCGAGCGTTTGGGCGTCAAGGTCCGGGTCGGGACCGAACAGGATTTACCGGCTTTTTATGAGCTGCTGAAGGTAACTTCAGAACGGGATCACTTCAAGGTGCGCAGTTTCTCCTACTTTTCCAATCTGTACCGGTCCTTAAAGGCTGAAGCGGCAGACCGTATTGCTCTTTATCTGGCGGAAGATGAAGAGGAATTATTGGCTGCTACCTTAGCCGTCCATTCCAACGCCCACTCATGGTATCTTTACGGGGCCAGCAGCAATGTAAAACGGGAGAAGGCCCCGAATCATGCTATCCAGTGGCGGATGATTCAAGATGCTTATCAGCTTAAGGCCTACACCTATGATTTTAGAGGCATCAGCCCTACCCTGGATGAATCTGACCCCCTGTTTGGGTTGTTGAGATTTAAATTGGGCTTTGGAGGCGAGGCTTGTGAAATGATCAGTGCTTGGGACTACCCCCTGCAGCCTTTATTATACCGGGCTTTCCAGCTGTACTTAAAACGGCGGTAG", "partial": "0", "query_start": 238, "query_end": 291, "orf_dna_sequence": "ATGAGCAACGCAAAAACAAAGTTAGGCATCACAAAGTACAGCATCGTGACCAACAGCAACGATTCCGTCACACTGCGCCTCATGACTGAGCATGACCTTGCGATGCTCTATGAGTGGCTAAATCGATCTCATATCGTCGAGTGGTGGGGCGGAGAAGAAGCA", "orf_prot_sequence": "MSNAKTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEA", "perc_identity": 50.0}}, "NODE_1_length_803036_cov_42.265_543 # 550760 # 553018 # -1 # ID=1_543;partial=00;start_type=ATG;rbs_motif=AGGA;rbs_spacer=5-10bp;gc_cont=0.593": {"gnl|BL_ORD_ID|2055|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "I", "position": 80}, "query_snp": {"original": "S", "change": "I", "position": 80}, "orf_strand": "-", "orf_start": 550760, "orf_end": 553018, "orf_from": "NODE_1_length_803036_cov_42.265_543 ", "model_name": "Escherichia coli parC conferring resistance to fluoroquinolone", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "1450", "pass_evalue": "n/a", "pass_bitscore": 1400, "ARO_accession": "3003308", "ARO_name": "Escherichia coli parC conferring resistance to fluoroquinolone", "ARO_category": {"36913": {"category_aro_accession": "3000619", "category_aro_cvterm_id": "36913", "category_aro_name": "fluoroquinolone resistant parC", "category_aro_description": "ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations.", "category_aro_class_name": "AMR Gene Family"}, "35942": {"category_aro_accession": "0000023", "category_aro_cvterm_id": "35942", "category_aro_name": "enoxacin", "category_aro_description": "Enoxacin belongs to a group called fluoroquinolones. Its mode of action depends upon blocking bacterial DNA replication by binding itself to DNA gyrase and causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "35988": {"category_aro_accession": "0000071", "category_aro_cvterm_id": "35988", "category_aro_name": "levofloxacin", "category_aro_description": "Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Its main target is topoisomerase IV, inhibiting its function and disrupting DNA replication.", "category_aro_class_name": "Antibiotic"}, "35991": {"category_aro_accession": "0000074", "category_aro_cvterm_id": "35991", "category_aro_name": "moxifloxacin", "category_aro_description": "Moxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases.", "category_aro_class_name": "Antibiotic"}, "37003": {"category_aro_accession": "3000659", "category_aro_cvterm_id": "37003", "category_aro_name": "gatifloxacin", "category_aro_description": "Gatifloxacin is an 8-methoxy, 7-piperazinyl, 6-fluoroquinolone that can be taken orally or by intravenous administration. It is active against most Gram-positive and Gram-negative bacteria, but inactive against non-fermenting Gram-negative rods including Pseudomonas aeruginosa.", "category_aro_class_name": "Antibiotic"}, "37004": {"category_aro_accession": "3000660", "category_aro_cvterm_id": "37004", "category_aro_name": "lomefloxacin", "category_aro_description": "Lomefloxacin is a difluoropiperazinyl quinolone, sharing similar activities with other fluoroquinolones. It is used to treat urinary tract infections. Relative to other fluoroquinolones, it has a longer half life and has higher serum concentrations.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "37006": {"category_aro_accession": "3000662", "category_aro_cvterm_id": "37006", "category_aro_name": "norfloxacin", "category_aro_description": "Norfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a wide range of activity against Gram-negative bacteria. It is inactive against most anaerobes.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "37008": {"category_aro_accession": "3000664", "category_aro_cvterm_id": "37008", "category_aro_name": "trovafloxacin", "category_aro_description": "Trovafloxacin is a trifluoroquinalone with a broad spectrum of activity that acts by inhibiting the uncoiling of supercoiled DNA. While potent against many Gram-positive and Gram-negative bacteria, it is less active against pseudomonads and Cl. difficile. It is usually taken as the prodrug trovafloxacin mesylate or alatrofloxacin mesylate for oral or intravenous administration, respectively.", "category_aro_class_name": "Antibiotic"}, "37009": {"category_aro_accession": "3000665", "category_aro_cvterm_id": "37009", "category_aro_name": "grepafloxacin", "category_aro_description": "Grepafloxacin is a broad-spectrum antibacterial quinoline. It is no longer taken due to its high toxicity.", "category_aro_class_name": "Antibiotic"}, "37010": {"category_aro_accession": "3000666", "category_aro_cvterm_id": "37010", "category_aro_name": "sparfloxacin", "category_aro_description": "Sparfloxacin is a dimethylpiperazinyl difluoroquinolone that acts by inhibiting DNA gyrase. It is active against aerobic Gram-positive and Gram-negative bacteria, as well as some mycobacteria. It has moderate activity against some anaerobes.", "category_aro_class_name": "Antibiotic"}, "37142": {"category_aro_accession": "3000762", "category_aro_cvterm_id": "37142", "category_aro_name": "pefloxacin", "category_aro_description": "Pefloxacin is structurally and functionally similar to norfloxacin. It is poorly active against mycobacteria, while anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 710, "bit_score": 1470.29, "cvterm_id": "36849", "query": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDIACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWSKEDGAVVISALPHQVSGAKVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDDRRSPLHEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAQGLSYKAGDSWKASAKGKSNQPVVFIDTTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVEHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPDNAHVMPPLVIEDESDMLLAITAAGRMLMFPVSDLPQLSKGKGNKIISIPAAEAAAGQDGLAHLFVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGSLMRGLQKIDRVEIDSPRRAAAGDSEE", "match": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGD ACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKY+ELLLSELGQGT DWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVA+AAI LI+QPKTTLD+LLDIVQGPD+PTEAEIITSRAEIRKIY+NGRGSVRMRAVW KEDGAVVISALPHQVSGA+VLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDM+QVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLN+RLEKVLKRLHILEGLLVAFLNIDEVIEIIR EDEPKPALMSRFG++ETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQ ILASERKMNNLLKKELQADA A+GDDRRSPL EREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDA GL+YKAGDS+KA+ KGKSNQPVVF+D+TGRSYAIDPITLPSARGQGEPLTGKLTLPPGATV+HMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLP+NAHVMPP+VIED SDMLLAIT AGRMLMFPVSDLPQLSKGKGNKII+IP+AEAA G+DGLA L+VLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRG+LMRGLQ+IDRVEIDSPRRA++GDSEE", "sequence_from_db": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE", "sequence_from_broadstreet": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVRMRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPLQEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSNQPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDLPQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE", "dna_sequence_from_broadstreet": "ATGAGCGATATGGCAGAGCGCCTTGCGCTACATGAATTTACGGAAAACGCCTACTTAAACTACTCCATGTACGTGATCATGGACCGTGCGTTGCCGTTTATTGGTGATGGTCTGAAACCTGTTCAGCGCCGCATTGTGTATGCGATGTCTGAACTGGGCCTGAATGCCAGCGCCAAATTTAAAAAATCGGCCCGTACCGTCGGTGACGTACTGGGTAAATACCATCCGCACGGCGATAGCGCCTGTTATGAAGCGATGGTCCTGATGGCGCAACCGTTCTCTTACCGTTATCCGCTGGTTGATGGTCAGGGGAACTGGGGCGCGCCGGACGATCCGAAATCGTTCGCGGCAATGCGTTACACCGAATCCCGGTTGTCGAAATATTCCGAGCTGCTATTGAGCGAGCTGGGGCAGGGGACGGCTGACTGGGTGCCAAACTTCGACGGCACTTTGCAGGAGCCGAAAATGCTACCTGCCCGTCTGCCAAACATTTTGCTTAACGGCACCACCGGTATTGCCGTCGGCATGGCGACCGATATTCCACCGCATAACCTGCGTGAAGTGGCTCAGGCGGCAATCGCATTAATCGACCAGCCGAAAACCACGCTCGATCAGCTGCTGGATATCGTGCAGGGGCCGGATTATCCGACTGAAGCGGAAATTATCACTTCGCGCGCCGAGATCCGTAAAATCTACGAGAACGGACGTGGTTCAGTGCGTATGCGCGCGGTGTGGAAGAAAGAAGATGGCGCGGTGGTTATCAGCGCATTGCCGCATCAGGTTTCAGGTGCGCGCGTACTGGAGCAAATTGCTGCGCAAATGCGCAACAAAAAGCTGCCGATGGTTGACGATCTGCGCGATGAATCTGACCACGAGAACCCGACCCGCCTGGTGATTGTGCCGCGTTCCAACCGCGTGGATATGGATCAGGTGATGAACCACCTCTTCGCTACCACCGATCTGGAAAAGAGCTATCGTATTAACCTTAATATGATCGGTCTGGATGGTCGTCCGGCGGTGAAAAACCTGCTGGAAATCCTCTCCGAATGGCTGGTGTTCCGCCGCGATACCGTGCGCCGCCGACTGAACTATCGTCTGGAGAAAGTCCTCAAGCGCCTGCATATCCTCGAAGGTTTGCTGGTGGCGTTTCTCAATATCGACGAAGTGATTGAGATCATTCGTAATGAAGATGAACCGAAACCGGCGCTGATGTCGCGGTTTGGCCTTACGGAAACCCAGGCGGAAGCGATCCTCGAACTGAAACTGCGTCATCTTGCCAAACTGGAAGAGATGAAGATTCGCGGTGAGCAGAGTGAACTGGAAAAAGAGCGCGACCAGTTGCAGGGCATTTTGGCTTCCGAGCGTAAAATGAATAACCTGCTGAAGAAAGAACTGCAGGCAGACGCGCAAGCCTACGGTGACGATCGTCGTTCGCCGTTGCAGGAACGCGAAGAAGCGAAAGCGATGAGCGAGCACGACATGCTGCCGTCTGAACCTGTCACCATTGTGCTGTCGCAGATGGGCTGGGTACGCAGCGCTAAAGGCCATGATATCGACGCGCCGGGCCTGAATTATAAAGCGGGTGATAGCTTCAAAGCGGCGGTGAAAGGTAAGAGCAACCAACCGGTAGTGTTTGTTGATTCCACCGGTCGTAGCTATGCCATTGACCCGATTACGCTGCCGTCGGCGCGTGGTCAGGGCGAGCCGCTCACCGGCAAATTAACGTTGCCGCCTGGGGCGACCGTTGACCATATGCTGATGGAAAGCGACGATCAGAAACTGCTGATGGCTTCCGATGCGGGTTACGGTTTCGTCTGCACCTTTAACGATCTGGTGGCGCGTAACCGTGCAGGTAAGGCTTTGATCACCTTACCGGAAAATGCCCATGTTATGCCGCCGGTGGTGATTGAAGATGCTTCCGATATGCTGCTGGCAATCACTCAGGCAGGCCGTATGTTGATGTTCCCGGTAAGTGATCTGCCGCAGCTGTCGAAGGGCAAAGGCAACAAGATTATCAACATTCCATCGGCAGAAGCCGCGCGTGGAGAAGATGGTCTGGCGCAATTGTACGTTCTGCCGCCGCAAAGCACGCTGACCATTCATGTTGGGAAACGCAAAATTAAACTGCGCCCGGAAGAGTTACAGAAAGTCACTGGCGAACGTGGACGCCGCGGTACGTTGATGCGCGGTTTGCAGCGTATCGATCGTGTTGAGATCGACTCTCCTCGCCGTGCCAGCAGCGGTGATAGCGAAGAGTAA", "partial": "0", "query_start": 550760, "query_end": 553015, "orf_dna_sequence": "ATGAGCGATATGGCAGAGCGCCTTGCGCTGCATGAATTTACGGAAAATGCTTACCTGAACTACTCCATGTACGTGATCATGGACAGGGCATTACCGTTTATTGGCGATGGCTTAAAACCGGTCCAGCGTCGCATCGTCTATGCGATGTCCGAGCTGGGGCTGAACGCCAGCGCGAAATTCAAAAAGTCCGCCCGCACCGTCGGCGACGTGTTGGGTAAATATCACCCGCACGGCGACATCGCCTGCTATGAAGCGATGGTGCTGATGGCGCAGCCGTTCTCTTACCGCTATCCGCTGGTGGATGGTCAGGGAAACTGGGGGGCGCCGGACGATCCCAAATCTTTCGCCGCCATGCGTTACACCGAATCCCGCCTGTCGAAGTATGCCGAGCTGCTGCTCAGCGAGCTGGGGCAGGGGACGGTCGACTGGGTGCCAAACTTTGACGGCACGCTGCAGGAGCCGAAAATGCTGCCAGCGCGTCTGCCGAACATCCTGCTGAACGGCACCACCGGCATCGCGGTAGGCATGGCGACCGATATTCCTCCGCACAACCTGCGGGAAGTGGCCAAAGCGGCGATTACGCTGATTGAGCAGCCGAAAACCACCCTCGACGAACTGCTGGATATCGTACAGGGGCCGGATTTCCCGACCGAGGCGGAGATCATCACCTCGCGGGCGGAAATTCGCAAAATCTACCAGAACGGGCGCGGCTCAGTGCGCATGCGTGCGGTGTGGAGTAAAGAGGACGGCGCGGTGGTGATCAGTGCGCTGCCGCATCAGGTCTCCGGCGCCAAAGTGCTGGAGCAGATTGCGGCGCAGATGCGCAATAAAAAGCTGCCGATGGTTGACGATCTGCGCGACGAATCGGACCACGAAAACCCGACCCGTCTGGTGATTGTCCCGCGCTCCAACCGGGTGGATATGGAACAGGTGATGAACCACCTGTTCGCCACCACCGATCTGGAGAAGAGCTACCGCATCAACCTCAATATGATCGGCCTTGACGGCCGCCCGGCGGTGAAAAACCTGCTGGAGATCCTCAGCGAGTGGCTGGTGTTCCGTCGCGATACCGTGCGTCGCCGTCTAAACCATCGGTTAGAGAAAGTGCTGAAGCGCCTGCATATCCTCGAAGGTTTGCTGGTGGCGTTTCTTAATATCGATGAAGTGATTGAGATCATCCGCACTGAAGATGAACCGAAGCCGGCCCTGATGTCGCGCTTTGGCATCAGCGAAACCCAGGCGGAAGCGATTCTGGAATTAAAACTGCGCCACCTCGCCAAACTGGAAGAGATGAAGATCCGCGGCGAGCAGAGCGAGCTGGAAAAAGAGCGCGACCAGCTGCAGGCGATTCTGGCGTCTGAACGTAAGATGAACAACCTGCTGAAAAAAGAGCTGCAGGCCGATGCCGATGCCTTCGGCGACGACCGTCGCTCGCCGCTTCACGAGCGTGAAGAAGCGAAAGCGATGAGCGAGCATGACATGCTGCCGTCTGAGCCGGTGACTATCGTTCTGTCGCAGATGGGCTGGGTGCGCAGCGCCAAAGGACACGACATTGACGCCCAGGGCTTGAGCTATAAGGCGGGCGACAGCTGGAAAGCCTCGGCGAAGGGCAAGAGCAACCAGCCGGTGGTGTTTATCGATACCACCGGACGCAGCTATGCCATCGATCCGATTACTCTGCCTTCCGCGCGTGGCCAGGGTGAACCGCTTACCGGCAAACTGACCCTGCCGCCGGGCGCGACCGTGGAGCATATGCTAATGGAAAGCGACGATCAGAAACTGCTGATGGCTTCCGACGCGGGCTACGGTTTCGTCTGTACCTTCAACGATCTGGTGGCGCGCAACCGTGCCGGTAAAGCGCTAATCACCCTGCCTGACAACGCGCACGTGATGCCGCCGCTGGTGATTGAGGATGAGTCCGATATGCTGCTGGCCATCACCGCCGCCGGGCGGATGCTGATGTTCCCGGTCAGCGATCTGCCGCAGCTGTCGAAAGGCAAGGGCAACAAAATTATCAGCATTCCGGCGGCGGAAGCCGCAGCCGGCCAGGACGGTCTGGCACATCTGTTTGTTCTGCCGCCGCAGAGTACGCTGACCATTCACGTCGGCAAACGGAAGATCAAACTGCGTCCGGAAGAGCTGCAAAAAGTCACCGGCGAGCGCGGCCGCCGCGGTTCGCTGATGCGCGGGCTGCAGAAAATTGACCGCGTGGAAATTGACTCGCCGCGTCGTGCCGCGGCAGGCGATAGCGAAGAGTAA", "orf_prot_sequence": "MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGDIACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWSKEDGAVVISALPHQVSGAKVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDDRRSPLHEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAQGLSYKAGDSWKASAKGKSNQPVVFIDTTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVEHMLMESDDQKLLMASDAGYGFVCTFNDLVARNRAGKALITLPDNAHVMPPLVIEDESDMLLAITAAGRMLMFPVSDLPQLSKGKGNKIISIPAAEAAAGQDGLAHLFVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRGSLMRGLQKIDRVEIDSPRRAAAGDSEE", "perc_identity": 94.41}}, "NODE_3_length_454317_cov_40.2449_130 # 161019 # 163652 # -1 # ID=3_130;partial=00;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.584": {"gnl|BL_ORD_ID|2531|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "F", "position": 83}, "query_snp": {"original": "S", "change": "F", "position": 83}, "orf_strand": "-", "orf_start": 161019, "orf_end": 163652, "orf_from": "NODE_3_length_454317_cov_40.2449_130 ", "model_name": "Salmonella enterica gyrA with mutation conferring resistance to triclosan", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2850", "pass_evalue": "n/a", "pass_bitscore": 1500, "ARO_accession": "3004334", "ARO_name": "Salmonella enterica gyrA with mutation conferring resistance to triclosan", "ARO_category": {"41501": {"category_aro_accession": "3004333", "category_aro_cvterm_id": "41501", "category_aro_name": "triclosan resistant gyrA", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 834, "bit_score": 1702.95, "cvterm_id": "35734", "query": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADT", "match": "MSDLAREITPVNIEEELK+SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGD AVY TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTE+IPDVMPTKIPNLLVNG+SGIAVGMATNIPPHNLTEVINGCLAY+D+EDISIEGLM HIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVE DAK+GRETIIVHEIPYQVNKARLIEKIAELVK+KRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDII+AFVRHRREVVTRRTIFELRKARDRAHILEALA+ALANIDPIIELIRRAPTPAEAK AL+++ WDLGNVAAMLERAGDDAARPEWLEPEFGVRDG+YYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREE+ELIRDQFGDERRTEITANSADINIEDLI+QEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEA+ERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLN+GDELIGVDLTSG DEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLA +D VVSLIIPRGEGAILTVTQNGYGKRTAA EYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSE+S+VGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGS AEGD+DIAPEA++", "sequence_from_db": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAES", "sequence_from_broadstreet": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE", "dna_sequence_from_broadstreet": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAGGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCACGGCGATTCCGCAGTGTATGACACCATCGTTCGTATGGCGCAGCCATTCTCGCTGCGTTACATGCTGGTGGATGGTCAGGGTAACTTCGGTTCTATTGACGGCGACTCCGCGGCGGCAATGCGTTATACGGAGATCCGTCTGGCGAAAATCGCCCACGAACTGATGGCCGATCTCGAAAAAGAGACGGTGGATTTCGTGGATAACTATGACGGTACGGAAAAAATTCCGGACGTCATGCCGACCAAAATTCCGAATCTGCTGGTGAACGGTTCTTCCGGTATCGCAGTAGGTATGGCGACGAATATCCCGCCGCACAACCTGACGGAAGTGATTAACGGCTGCCTGGCGTATATCGACAACGAAGACATCAGCATTGAAGGGCTGATGGAACATATTCCGGGGCCGGACTTCCCGACCGCCGCGATCATCAACGGTCGTCGTGGTATCGAAGAAGCCTACCGCACCGGTCGTGGCAAAGTGTACATTCGCGCCCGCGCGGAAGTTGAAGCTGACGCCAAAACGGGCCGTGAAACCATCATCGTCCATGAAATTCCCTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTGAAAGATAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAATCCGACAAAGACGGGATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTGGGCGAGGTGGTGCTTAATAATCTCTACTCCCAGACCCAGCTACAGGTTTCCTTCGGTATTAACATGGTGGCGCTGCATCACGGCCAGCCGAAGATCATGAACCTGAAAGATATCATTTCAGCGTTCGTGCGCCACCGCCGTGAAGTGGTGACGCGTCGGACTATTTTTGAACTGCGTAAAGCCCGTGACCGTGCGCATATCCTTGAAGCTCTGGCGATTGCGCTGGCCAACATCGACCCGATTATCGAACTGATTCGCCGCGCGCCAACGCCGGCGGAAGCAAAAGCGGCGCTGATTTCGCGTCCGTGGGATCTGGGCAACGTTGCTGCGATGCTGGAGCGCGCTGGTGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAATTTGGCGTGCGTGACGGTCAGTACTACCTGACTGAACAGCAGGCGCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGCCTGGAGCATGAAAAACTGCTCGACGAATACAAAGAGCTGCTGGAGCAGATTGCTGAATTGCTGCACATTCTGGGCAGCGCCGATCGCCTGATGGAAGTGATCCGCGAAGAGATGGAGTTAATTCGCGATCAGTTCGGCGATGAGCGTCGTACCGAAATCACCGCCAACAGCGCCGATATTAATATCGAAGATCTGATTAGCCAGGAAGATGTTGTCGTGACGCTGTCTCACCAGGGTTACGTCAAATATCAACCGCTGACAGATTACGAAGCGCAACGTCGTGGTGGGAAAGGTAAATCTGCCGCGCGTATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCCAGCCGGGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAAGCCAACGAACGTATCACCGCGATTCTGCCGGTTCGTGAGTATGAAGAAGGCGTCAACGTCTTTATGGCGACCGCCAGCGGTACCGTGAAGAAAACGGCGCTGACCGAATTCAGCCGTCCGCGTTCCGCCGGTATTATCGCGGTGAACCTCAACGACGGCGACGAGCTGATTGGCGTTGACCTGACTTCTGGTTCTGACGAAGTCATGCTGTTCTCGGCCGCGGGTAAAGTGGTGCGCTTCAAAGAAGACGCCGTCCGTGCGATGGGGCGTACCGCGACCGGTGTGCGCGGTATTAAGCTGGCGGGAGACGATAAAGTCGTCTCTCTGATCATCCCACGCGGCGAAGGCGCTATTCTGACCGTAACGCAAAACGGCTACGGGAAGCGTACCGCAGCGGACGAGTACCCGACCAAGTCTCGTGCGACGCAGGGCGTTATCTCTATCAAAGTGACCGAGCGCAACGGTTCCGTTGTCGGTGCGGTACAGGTAGACGATTGCGACCAGATCATGATGATCACGGATGCCGGTACTCTGGTGCGTACCCGTGTGTCCGAGATCAGCGTAGTGGGACGTAATACCCAGGGCGTTATCCTTATCCGCACGGCGGAAGATGAAAACGTGGTGGGTCTGCAACGCGTTGCTGAACCGGTAGATGACGAAGAACTCGACGCTATCGACGGCAGCGTGGCGGAAGGGGATGAGGATATCGCCCCGGAAGCGGAAAGCGATGACGACGTTGCGGATGACGCTGACGAGTAA", "partial": "0", "query_start": 161019, "query_end": 163622, "orf_dna_sequence": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCACGGCGACTTCGCGGTATACGCCACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGGTAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGCTGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCGACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCTGACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTGGCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTGTACATTCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTCTATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCTGAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGCGCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCGCCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGCCGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTATCTGACCGAGCAGCAGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAGCTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGAGCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGATCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAGCGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTAGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATTACCGCCATCCTGCCGGTCCGCGAGTACGAAGAGGGCGTCAACGTCTTTATGGCCACCGCCAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCGTTCCGCCGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAGTGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAGGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGCGTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGTGACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGCGCCACCCAGGGCGTTATTTCGATCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGACGCCGGGACGCTGGTGCGTACCCGCGTTTCCGAGGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCACCGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTAGCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA", "orf_prot_sequence": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE", "perc_identity": 96.08}, "gnl|BL_ORD_ID|2220|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "F", "position": 83}, "query_snp": {"original": "S", "change": "F", "position": 83}, "orf_strand": "-", "orf_start": 161019, "orf_end": 163652, "orf_from": "NODE_3_length_454317_cov_40.2449_130 ", "model_name": "Salmonella enterica gyrA conferring resistance to fluoroquinolones", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2403", "pass_evalue": "n/a", "pass_bitscore": 1500, "ARO_accession": "3003926", "ARO_name": "Salmonella enterica gyrA conferring resistance to fluoroquinolones", "ARO_category": {"39876": {"category_aro_accession": "3003292", "category_aro_cvterm_id": "39876", "category_aro_name": "fluoroquinolone resistant gyrA", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. GyrA point mutations confer resistance by preventing fluoroquinolone antibiotics from binding the alpha-subunit.", "category_aro_class_name": "AMR Gene Family"}, "35954": {"category_aro_accession": "0000036", "category_aro_cvterm_id": "35954", "category_aro_name": "ciprofloxacin", "category_aro_description": "Ciprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.", "category_aro_class_name": "Antibiotic"}, "37005": {"category_aro_accession": "3000661", "category_aro_cvterm_id": "37005", "category_aro_name": "nalidixic acid", "category_aro_description": "Nalidixic acid is a quinolone derivative of naphthyridine active against many enterobacteria, but ineffective against Ps aeruginosa, Gram-positive bacteria, and anaerobes. Acquired resistance is common in nalidixic acid treatments.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 834, "bit_score": 1702.95, "cvterm_id": "35734", "query": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADT", "match": "MSDLAREITPVNIEEELK+SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGD AVY TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTE+IPDVMPTKIPNLLVNG+SGIAVGMATNIPPHNLTEVINGCLAY+D+EDISIEGLM HIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVE DAK+GRETIIVHEIPYQVNKARLIEKIAELVK+KRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDII+AFVRHRREVVTRRTIFELRKARDRAHILEALA+ALANIDPIIELIRRAPTPAEAK AL+++ WDLGNVAAMLERAGDDAARPEWLEPEFGVRDG+YYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREE+ELIRDQFGDERRTEITANSADINIEDLI+QEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEA+ERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLN+GDELIGVDLTSG DEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLA +D VVSLIIPRGEGAILTVTQNGYGKRTAA EYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSE+S+VGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGS AEGD+DIAPEA++", "sequence_from_db": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAES", "sequence_from_broadstreet": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE", "dna_sequence_from_broadstreet": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAGGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCACGGCGATTCCGCAGTGTATGACACCATCGTTCGTATGGCGCAGCCATTCTCGCTGCGTTACATGCTGGTGGATGGTCAGGGTAACTTCGGTTCTATTGACGGCGACTCCGCGGCGGCAATGCGTTATACGGAGATCCGTCTGGCGAAAATCGCCCACGAACTGATGGCCGATCTCGAAAAAGAGACGGTGGATTTCGTGGATAACTATGACGGTACGGAAAAAATTCCGGACGTCATGCCGACCAAAATTCCGAATCTGCTGGTGAACGGTTCTTCCGGTATCGCAGTAGGTATGGCGACGAATATCCCGCCGCACAACCTGACGGAAGTGATTAACGGCTGCCTGGCGTATATCGACAACGAAGACATCAGCATTGAAGGGCTGATGGAACATATTCCGGGGCCGGACTTCCCGACCGCCGCGATCATCAACGGTCGTCGTGGTATCGAAGAAGCCTACCGCACCGGTCGTGGCAAAGTGTACATTCGCGCCCGCGCGGAAGTTGAAGCTGACGCCAAAACGGGCCGTGAAACCATCATCGTCCATGAAATTCCCTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTGAAAGATAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAATCCGACAAAGACGGGATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTGGGCGAGGTGGTGCTTAATAATCTCTACTCCCAGACCCAGCTACAGGTTTCCTTCGGTATTAACATGGTGGCGCTGCATCACGGCCAGCCGAAGATCATGAACCTGAAAGATATCATTTCAGCGTTCGTGCGCCACCGCCGTGAAGTGGTGACGCGTCGGACTATTTTTGAACTGCGTAAAGCCCGTGACCGTGCGCATATCCTTGAAGCTCTGGCGATTGCGCTGGCCAACATCGACCCGATTATCGAACTGATTCGCCGCGCGCCAACGCCGGCGGAAGCAAAAGCGGCGCTGATTTCGCGTCCGTGGGATCTGGGCAACGTTGCTGCGATGCTGGAGCGCGCTGGTGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAATTTGGCGTGCGTGACGGTCAGTACTACCTGACTGAACAGCAGGCGCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGCCTGGAGCATGAAAAACTGCTCGACGAATACAAAGAGCTGCTGGAGCAGATTGCTGAATTGCTGCACATTCTGGGCAGCGCCGATCGCCTGATGGAAGTGATCCGCGAAGAGATGGAGTTAATTCGCGATCAGTTCGGCGATGAGCGTCGTACCGAAATCACCGCCAACAGCGCCGATATTAATATCGAAGATCTGATTAGCCAGGAAGATGTTGTCGTGACGCTGTCTCACCAGGGTTACGTCAAATATCAACCGCTGACAGATTACGAAGCGCAACGTCGTGGTGGGAAAGGTAAATCTGCCGCGCGTATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCCAGCCGGGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAAGCCAACGAACGTATCACCGCGATTCTGCCGGTTCGTGAGTATGAAGAAGGCGTCAACGTCTTTATGGCGACCGCCAGCGGTACCGTGAAGAAAACGGCGCTGACCGAATTCAGCCGTCCGCGTTCCGCCGGTATTATCGCGGTGAACCTCAACGACGGCGACGAGCTGATTGGCGTTGACCTGACTTCTGGTTCTGACGAAGTCATGCTGTTCTCGGCCGCGGGTAAAGTGGTGCGCTTCAAAGAAGACGCCGTCCGTGCGATGGGGCGTACCGCGACCGGTGTGCGCGGTATTAAGCTGGCGGGAGACGATAAAGTCGTCTCTCTGATCATCCCACGCGGCGAAGGCGCTATTCTGACCGTAACGCAAAACGGCTACGGGAAGCGTACCGCAGCGGACGAGTACCCGACCAAGTCTCGTGCGACGCAGGGCGTTATCTCTATCAAAGTGACCGAGCGCAACGGTTCCGTTGTCGGTGCGGTACAGGTAGACGATTGCGACCAGATCATGATGATCACGGATGCCGGTACTCTGGTGCGTACCCGTGTGTCCGAGATCAGCGTAGTGGGACGTAATACCCAGGGCGTTATCCTTATCCGCACGGCGGAAGATGAAAACGTGGTGGGTCTGCAACGCGTTGCTGAACCGGTAGATGACGAAGAACTCGACGCTATCGACGGCAGCGTGGCGGAAGGGGATGAGGATATCGCCCCGGAAGCGGAAAGCGATGACGACGTTGCGGATGACGCTGACGAGTAA", "partial": "0", "query_start": 161019, "query_end": 163622, "orf_dna_sequence": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCACGGCGACTTCGCGGTATACGCCACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGGTAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGCTGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCGACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCTGACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTGGCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTGTACATTCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTCTATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCTGAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGCGCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCGCCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGCCGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTATCTGACCGAGCAGCAGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAGCTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGAGCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGATCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAGCGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTAGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATTACCGCCATCCTGCCGGTCCGCGAGTACGAAGAGGGCGTCAACGTCTTTATGGCCACCGCCAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCGTTCCGCCGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAGTGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAGGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGCGTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGTGACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGCGCCACCCAGGGCGTTATTTCGATCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGACGCCGGGACGCTGGTGCGTACCCGCGTTTCCGAGGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCACCGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTAGCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA", "orf_prot_sequence": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE", "perc_identity": 96.08}, "gnl|BL_ORD_ID|2532|hsp_num:0": {"type_match": "Strict", "snp": {"original": "S", "change": "F", "position": 83}, "query_snp": {"original": "S", "change": "F", "position": 83}, "orf_strand": "-", "orf_start": 161019, "orf_end": 163652, "orf_from": "NODE_3_length_454317_cov_40.2449_130 ", "model_name": "Escherichia coli gyrA with mutation conferring resistance to triclosan", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2851", "pass_evalue": "n/a", "pass_bitscore": 1500, "ARO_accession": "3004335", "ARO_name": "Escherichia coli gyrA with mutation conferring resistance to triclosan", "ARO_category": {"41501": {"category_aro_accession": "3004333", "category_aro_cvterm_id": "41501", "category_aro_name": "triclosan resistant gyrA", "category_aro_description": "DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA.", "category_aro_class_name": "AMR Gene Family"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 806, "bit_score": 1639.01, "cvterm_id": "36849", "query": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAED", "match": "MSDLAREITPVNIEEELK+SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGD AVY TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTE+IPDVMPTKIPNLLVNG+SGIAVGMATNIPPHNLTEVINGCLAY+DDEDISIEGLM HIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAK+GRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIR APTPAEAKTALVA  W LGNVAAMLERAGDDAARPEWLEPEFGVRDG YYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELL+QIAELL ILGSADRLMEVIREELEL+R+QFGD+RRTEITANSADIN+EDLI QEDVVVTLSHQGYVKYQPL++YEAQRRGGKGKSAARIKEEDFIDRLLVANTHD ILCFSSRGR+Y MKVYQLPEA+RGARGRPIVNLLPLE DERITAILPV E+EEGV VFMATA+GTVKKT LTEF+R R+AG +A+ L +GDELIGVDLTSG+DEVMLFSA GKVVRFKE +VRAMG   TGVRGI+L E D VVSLI+PRG+GAILT TQNGYGKRTA AEYPTKSRAT+GVISIKVTERNG VVGAVQVDDCDQIMMITDAGTLVRTRVSE+SIVGRNTQGVILIRTAEDENVVGLQRVAEPVD+E+LD IDGSAAEGDD+IAPE D DD+  E+", "sequence_from_db": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE", "sequence_from_broadstreet": "MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE", "dna_sequence_from_broadstreet": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCAGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTACTAGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCATGGTGACTCGGCGGTCTATGACACGATCGTCCGCATGGCGCAGCCATTCTCGCTGCGTTATATGCTGGTAGACGGTCAGGGTAACTTCGGTTCTATCGACGGCGACTCTGCGGCGGCAATGCGTTATACGGAAATCCGTCTGGCGAAAATTGCCCATGAACTGATGGCCGATCTCGAAAAAGAGACGGTCGATTTCGTTGATAACTATGACGGCACGGAAAAAATTCCGGACGTCATGCCAACCAAAATTCCTAACCTGCTGGTGAACGGTTCTTCCGGTATCGCCGTAGGTATGGCAACCAACATCCCGCCGCACAACCTGACGGAAGTCATCAACGGTTGTCTGGCGTATATTGATGATGAAGACATCAGCATTGAAGGGCTGATGGAACACATCCCGGGGCCGGACTTCCCGACGGCGGCAATCATTAACGGTCGTCGCGGTATTGAAGAAGCTTACCGTACCGGTCGCGGCAAGGTGTATATCCGCGCTCGCGCAGAAGTGGAAGTTGACGCCAAAACCGGTCGTGAAACCATTATCGTCCACGAAATTCCGTATCAGGTAAACAAAGCGCGCCTGATCGAGAAGATTGCGGAACTGGTAAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGACAAAGACGGTATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTCGGTGAAGTTGTGCTCAACAACCTCTACTCCCAGACCCAGTTGCAGGTTTCTTTCGGTATCAACATGGTGGCATTGCACCATGGTCAGCCGAAGATCATGAACCTGAAAGACATCATCGCGGCGTTTGTTCGTCACCGCCGTGAAGTGGTGACCCGTCGTACTATTTTCGAACTGCGTAAAGCTCGCGATCGTGCTCATATCCTTGAAGCATTAGCCGTGGCGCTGGCGAACATCGACCCGATCATCGAACTGATCCGTCATGCGCCGACGCCTGCAGAAGCGAAAACTGCGCTGGTTGCTAATCCGTGGCAGCTGGGCAACGTTGCCGCGATGCTCGAACGTGCTGGCGACGATGCTGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTGCGTGATGGTCTGTACTACCTGACCGAACAGCAAGCTCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGTCTTGAGCACGAAAAACTGCTCGACGAATACAAAGAGCTGCTGGATCAGATCGCGGAACTGTTGCGTATTCTTGGTAGCGCCGATCGTCTGATGGAAGTGATCCGTGAAGAGCTGGAGCTGGTTCGTGAACAGTTCGGTGACAAACGTCGTACTGAAATCACCGCCAACAGCGCAGACATCAACCTGGAAGATCTGATCACCCAGGAAGATGTGGTCGTGACGCTCTCTCACCAGGGCTACGTTAAGTATCAGCCGCTTTCTGAATACGAAGCGCAGCGTCGTGGCGGGAAAGGTAAATCTGCCGCACGTATTAAAGAAGAAGACTTTATCGACCGACTGCTGGTGGCGAACACTCACGACCATATTCTGTGCTTCTCCAGCCGTGGTCGCGTCTATTCGATGAAAGTTTATCAGTTGCCGGAAGCCACTCGTGGCGCGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAGCAGGACGAACGTATCACTGCGATCCTGCCAGTGACCGAGTTTGAAGAAGGCGTGAAAGTCTTCATGGCGACCGCTAACGGTACCGTGAAGAAAACTGTCCTCACCGAGTTCAACCGTCTGCGTACCGCCGGTAAAGTGGCGATCAAACTGGTTGACGGCGATGAGCTGATCGGCGTTGACCTGACCAGCGGCGAAGACGAAGTAATGCTGTTCTCCGCTGAAGGTAAAGTGGTGCGCTTTAAAGAGTCTTCTGTCCGTGCGATGGGCTGCAACACCACCGGTGTTCGCGGTATTCGCTTAGGTGAAGGCGATAAAGTCGTCTCTCTGATCGTGCCTCGTGGCGATGGCGCAATCCTCACCGCAACGCAAAACGGTTACGGTAAACGTACCGCAGTGGCGGAATACCCAACCAAGTCGCGTGCGACGAAAGGGGTTATCTCCATCAAGGTTACCGAACGTAACGGTTTAGTTGTTGGCGCGGTACAGGTAGATGACTGCGACCAGATCATGATGATCACCGATGCCGGTACGCTGGTACGTACTCGCGTTTCGGAAATCAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGTACTGCGGAAGATGAAAACGTAGTGGGTCTGCAACGTGTTGCTGAACCGGTTGACGAGGAAGATCTGGATACCATCGACGGCAGTGCCGCGGAAGGGGACGATGAAATCGCTCCGGAAGTGGACGTTGACGACGAGCCAGAAGAAGAATAA", "partial": "0", "query_start": 161019, "query_end": 163643, "orf_dna_sequence": "ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTCGGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCACGGCGACTTCGCGGTATACGCCACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGGTAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGCTGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCGACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCTGACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTGGCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTGTACATTCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCAGGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTCTATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCTGAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGCGCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCGCCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGCCGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTATCTGACCGAGCAGCAGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAGCTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGAGCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGATCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAGCGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTAGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATTACCGCCATCCTGCCGGTCCGCGAGTACGAAGAGGGCGTCAACGTCTTTATGGCCACCGCCAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCGTTCCGCCGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAGTGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAGGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGCGTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGTGACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGCGCCACCCAGGGCGTTATTTCGATCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGACGCCGGGACGCTGGTGCGTACCCGCGTTTCCGAGGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCACCGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTAGCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA", "orf_prot_sequence": "MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDFAVYATIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE", "perc_identity": 92.11}}, "NODE_4_length_367278_cov_42.3139_202 # 219948 # 221714 # 1 # ID=4_202;partial=00;start_type=ATG;rbs_motif=AGGA/GGAG/GAGG;rbs_spacer=11-12bp;gc_cont=0.564": {"gnl|BL_ORD_ID|2567|hsp_num:0": {"type_match": "Strict", "snp": {"original": "D", "change": "N", "position": 350}, "query_snp": {"original": "D", "change": "N", "position": 327}, "orf_strand": "+", "orf_start": 219948, "orf_end": 221714, "orf_from": "NODE_4_length_367278_cov_42.3139_202 ", "model_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2886", "pass_evalue": "n/a", "pass_bitscore": 500, "ARO_accession": "3004446", "ARO_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "ARO_category": {"40661": {"category_aro_accession": "3003938", "category_aro_cvterm_id": "40661", "category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 297, "bit_score": 593.964, "cvterm_id": "41640", "query": "APKTPKAKRQEE--QANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSG-LYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALA", "match": "AP+T K  + ++  +  F+  R+ L    ILL L  L+ R A++Q I+ D L  + D RSLR  EV + RG I DR+G+ L+VSVP+ AI ADPK +     +    R  ALA+ L M  + L  +I  N +  ++YLARQV    A+YI++LK+ GI L  E RR+YP  E  AH++G+T++D  GIEG+EKSF+  L G+ G R VRKD+ G ++  IS      A ++ LSIDE+LQ++VYRE+  AV+ N AESG+AVLVDV TGEVLAMA +PSYNPNN  G   + MRNRAITD FEPGSTVKP VV+T LQRG+V  + +++T  ++++G EI DVA  ++ TL  +L  SSN GVS+LAL MP SAL++TY   GL K T+LGL+GE+ G L   ++RW+DIERAT ++GYG+  TPLQ+AR YAT+GS+G+YRPLSITKVDPPV G+RVF E + + +V ++E VA+      +A ++GYR+ +KTGTA+K+  +G Y+NKY+A+TAG+AP S PR+ALVV+INDP+AG+YYGGAVSAPVF  IMG  LR   I  DA A", "sequence_from_db": "APETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNK---RAMVEGYRVGVKTGTARKI-ENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEA", "sequence_from_broadstreet": "MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN", "dna_sequence_from_broadstreet": "ATGGTGAAATTTAATTCCTCGCGTAAATCAGGTAAGTCAAAAAAAACAATTAGAAAATTGACCGCACCTGAAACTGTAAAGCAAAACAAGCCTCAAAAGGTGTTTGAAAAATGCTTTATGCGTGGACGTTATATGCTTTCTACGGTTCTTATTTTACTTGGCCTGTGTGCTTTAGTCGCACGAGCAGCTTATGTTCAATCTATTAATGCCGATACGTTATCGAATGAAGCGGATAAGCGTTCTTTGCGTAAAGATGAAGTATTATCGGTGCGTGGTTCTATTTTAGATCGTAATGGTCAGCTTTTATCTGTAAGCGTGCCGATGAGCGCGATTGTGGCAGATCCAAAAACGATGTTGAAGGAAAATTCGCTTGCGGATAAAGAACGAATTGCAGCTTTAGCCGAAGAATTAGGTATGACTGAAAATGATTTAGTGAAAAAAATTGAGAAAAATTCTAAATCTGGTTATTTGTATTTAGCACGTCAAGTTGAATTAAGTAAAGCTAACTATATTCGTAGATTAAAAATTAAGGGTATTATTTTAGAAACAGAGCATCGCCGTTTTTATCCTCGTGTAGAAGAAGCTGCACACGTGGTGGGTTATACGGATATTGATGGAAATGGTATTGAAGGCATTGAGAAAAGTTTTAATTCCCTGCTTGTTGGTAAAGACGGTTCACGTACTGTTCGTAAAGATAAACGTGGGAATATTGTTGCACATATCTCCGATGAGAAAAAATATGATGCACAAGATGTTACCTTAAGTATCGATGAAAAATTGCAATCTATGGTGTATCGTGAGATTAAAAAGGCGGTGTCTGAGAATAATGCTGAGTCTGGTACTGCGGTGTTAGTTGATGTTCGAACAGGGGAAGTGTTAGCTATGGCGACTGCGCCCTCTTATAATCCAAACAACCGTGTCGGCGTGAAATCAGAGTTAATGCGTAACCGTGCAATTACCGATACTTTTGAGCCAGGTTCTACGGTAAAACCTTTCGTTGTTTTAACCGCACTTCAACGAGGTGTAGTTAAACGAGATGAAATTATTGATACTACGTCCTTTAAATTAAGCGGTAAAGAAATTGTGGACGTTGCACCACGTGCTCAGCAAACTTTAGACGAGATTTTAATGAACTCTAGTAACCGTGGTGTAAGTCGTCTTGCATTACGTATGCCACCTAGTGCATTAATGGAAACTTATCAAAATGCAGGTTTAAGTAAACCGACAGATTTAGGCTTGATCGGAGAGCAAGTTGGGATTTTGAATGCAAATCGTAAACGCTGGGCAGATATTGAGCGTGCAACAGTCGCTTATGGTTATGGTATTACTGCGACACCTTTACAAATTGCTCGTGCCTATGCAACCCTTGGTAGTTTCGGTGTTTATCGTCCGCTTTCTATCACTAAAGTTGATCCGCCAGTTATTGGGAAACGGGTTTTCTCTGAAAAAATAACTAAAGATATTGTGGGAATTTTAGAGAAAGTAGCAATTAAAAATAAACGCGCAATGGTGGAAGGCTACCGTGTCGGCGTAAAAACAGGTACGGCACGTAAGATTGAAAATGGACATTATGTAAATAAGTATGTGGCATTTACTGCGGGTATTGCACCAATTAGTGATCCTCGTTATGCATTAGTGGTTTTGATCAATGATCCAAAAGCAGGAGAATATTATGGTGGTGCGGTTTCTGCCCCTGTATTCTCTAACATTATGGGCTATGCGTTACGTGCAAATGCTATTCCGCAAGATGCTGAAGCAGCTGAAAACACAACAACGAAAAGTGCAAAACGTATTGTTTATATTGGCGAACACAAGAATCAAAAAGTGAATTAA", "partial": "0", "query_start": 219957, "query_end": 221654, "orf_dna_sequence": "ATGAAAGCAGCGCCAAAAACGCCTAAAGCAAAACGTCAGGAAGAACAGGCCAACTTTATCAGTTGGCGTTTTGCGTTGCTGTGCGGCTGTATTCTGCTGGCGCTGGCTTTTCTGCTGGGTCGCGTCGCCTGGCTACAGGTGATCAGCCCCGATATGCTGGTGCGCCAGGGCGATATGCGTTCTCTGCGCGTACAGGAAGTGTCCACCGCGCGCGGGATGATTACCGATCGCTCCGGACGTCCGCTGGCGGTCAGCGTGCCGGTGAAGGCTATCTGGGCCGACCCGAAAGAGCTCCATGACGCCGGCGGGGTTACCCTGGATACGCGCTGGAAAGCGCTGGCGGATGCCCTCAATATGCCGCTGGATCAGCTGGCGACGCGCATCAATACCAATCCGCGGATGCGGTTTATCTATCTGGCGCGTCAGGTTAACCCTGACATGGCCGATTACATCAAGAAGCTGAAGCTGCCGGGCATTCATCTGCGCGAAGAATCCCGTCGGTACTACCCTTCCGGGGAAGTAACCGCTCACCTCATCGGCTTTACCAACGTCGATAGCCAGGGGATTGAAGGGGTTGAAAAAAGCTTTGATAAATGGCTTACCGGTCAGCCGGGCGAGCGTATCGTGCGTAAAGACCGCTATGGCCGGGTAATTGAAGACATCTCTTCTACCGATAGCCAGGCAGCGCACAACCTGGCGCTGAGTATCGACGAACGCCTGCAGGCGCTGGTCTATCGCGAGCTAAACAACGCCGTGGCCTTTAACAAAGCCGAGTCGGGCAGCGCCGTGTTAGTAGATGTTAACACCGGTGAAGTGCTGGCGATGGCCAACAGCCCATCCTATAACCCGAACAACTTCGCCGGTACGGCAAAAGACACCATGCGTAACCGTGCGATTACCGACGTGTTTGAGCCGGGTTCGACGGTGAAACCGATGGTGGTCATGACGGTGCTGCAGCGCGGTATCGTCAACGAAAATACCGTGCTCAATACCGTGCCTTATCGAATTAACGGCCACGAAATCAAAGACGTGGCGCGCTACAGCGAATTGACCCTGACCGGGGTGCTACAGAAGTCGAGTAACGTCGGTGTTTCTAAGCTGGCGTTAGCGATGCCGTCCTCAGCGTTAGTAGATACTTACTCACGTTTTGGGCTTGGAAAGGCGACCAATTTGGGGTTGGTCGGAGAACGCAGTGGCTTATATCCTCAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTTTCTTTCGGCTATGGGCTAATGGTAACCCCGTTACAGTTAGCGCGAGTCTACGCAACGATTGGCAGCTATGGCATCTATCGCCCGTTGTCGATTACCAAAGTTGATCCTCCGGTTCCGGGCGAGCGCGTCTTCCCGGAATCACTCGTTCGTACCGTCGTTCATATGATGGAAAGCGTGGCGCTGCCCGGCGGCGGCGGTGTGAAAGCGGCGATCAAAGGCTATCGCATCGCGATTAAAACCGGTACGGCGAAAAAAGTGGGGCCGGATGGCCGCTATATCAACAAATATATTGCTTACACCGCAGGCGTTGCGCCCGCCAGCCATCCGCGCTTCGCGCTGGTGGTGGTGATCAACGACCCGCAGGCAGGTAAATACTACGGTGGCGCCGTTTCCGCGCCGGTCTTCGGTGCCATCATGGGCGGCGTATTGCGCACCATGAACATCGAGCCGGATGCGCTGGCAACGGGCGAAAAAAGTGAATTTGTAATTAATCAAGGCGAGGGAACAGGTGGCAGATCGTAA", "orf_prot_sequence": "MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS", "perc_identity": 52.2}, "gnl|BL_ORD_ID|2567|hsp_num:1": {"type_match": "Strict", "snp": {"original": "S", "change": "N", "position": 357}, "query_snp": {"original": "S", "change": "N", "position": 334}, "orf_strand": "+", "orf_start": 219948, "orf_end": 221714, "orf_from": "NODE_4_length_367278_cov_42.3139_202 ", "model_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2886", "pass_evalue": "n/a", "pass_bitscore": 500, "ARO_accession": "3004446", "ARO_name": "Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics", "ARO_category": {"40661": {"category_aro_accession": "3003938", "category_aro_cvterm_id": "40661", "category_aro_name": "Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics", "category_aro_description": "Mutations in PBP transpeptidases that change the affinity for penicillin thereby conferring resistance to penicillin antibiotics", "category_aro_class_name": "AMR Gene Family"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35962": {"category_aro_accession": "0000044", "category_aro_cvterm_id": "35962", "category_aro_name": "cephamycin", "category_aro_description": "Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 297, "bit_score": 593.964, "cvterm_id": "41640", "query": "APKTPKAKRQEE--QANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSG-LYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALA", "match": "AP+T K  + ++  +  F+  R+ L    ILL L  L+ R A++Q I+ D L  + D RSLR  EV + RG I DR+G+ L+VSVP+ AI ADPK +     +    R  ALA+ L M  + L  +I  N +  ++YLARQV    A+YI++LK+ GI L  E RR+YP  E  AH++G+T++D  GIEG+EKSF+  L G+ G R VRKD+ G ++  IS      A ++ LSIDE+LQ++VYRE+  AV+ N AESG+AVLVDV TGEVLAMA +PSYNPNN  G   + MRNRAITD FEPGSTVKP VV+T LQRG+V  + +++T  ++++G EI DVA  ++ TL  +L  SSN GVS+LAL MP SAL++TY   GL K T+LGL+GE+ G L   ++RW+DIERAT ++GYG+  TPLQ+AR YAT+GS+G+YRPLSITKVDPPV G+RVF E + + +V ++E VA+      +A ++GYR+ +KTGTA+K+  +G Y+NKY+A+TAG+AP S PR+ALVV+INDP+AG+YYGGAVSAPVF  IMG  LR   I  DA A", "sequence_from_db": "APETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNK---RAMVEGYRVGVKTGTARKI-ENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEA", "sequence_from_broadstreet": "MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN", "dna_sequence_from_broadstreet": "ATGGTGAAATTTAATTCCTCGCGTAAATCAGGTAAGTCAAAAAAAACAATTAGAAAATTGACCGCACCTGAAACTGTAAAGCAAAACAAGCCTCAAAAGGTGTTTGAAAAATGCTTTATGCGTGGACGTTATATGCTTTCTACGGTTCTTATTTTACTTGGCCTGTGTGCTTTAGTCGCACGAGCAGCTTATGTTCAATCTATTAATGCCGATACGTTATCGAATGAAGCGGATAAGCGTTCTTTGCGTAAAGATGAAGTATTATCGGTGCGTGGTTCTATTTTAGATCGTAATGGTCAGCTTTTATCTGTAAGCGTGCCGATGAGCGCGATTGTGGCAGATCCAAAAACGATGTTGAAGGAAAATTCGCTTGCGGATAAAGAACGAATTGCAGCTTTAGCCGAAGAATTAGGTATGACTGAAAATGATTTAGTGAAAAAAATTGAGAAAAATTCTAAATCTGGTTATTTGTATTTAGCACGTCAAGTTGAATTAAGTAAAGCTAACTATATTCGTAGATTAAAAATTAAGGGTATTATTTTAGAAACAGAGCATCGCCGTTTTTATCCTCGTGTAGAAGAAGCTGCACACGTGGTGGGTTATACGGATATTGATGGAAATGGTATTGAAGGCATTGAGAAAAGTTTTAATTCCCTGCTTGTTGGTAAAGACGGTTCACGTACTGTTCGTAAAGATAAACGTGGGAATATTGTTGCACATATCTCCGATGAGAAAAAATATGATGCACAAGATGTTACCTTAAGTATCGATGAAAAATTGCAATCTATGGTGTATCGTGAGATTAAAAAGGCGGTGTCTGAGAATAATGCTGAGTCTGGTACTGCGGTGTTAGTTGATGTTCGAACAGGGGAAGTGTTAGCTATGGCGACTGCGCCCTCTTATAATCCAAACAACCGTGTCGGCGTGAAATCAGAGTTAATGCGTAACCGTGCAATTACCGATACTTTTGAGCCAGGTTCTACGGTAAAACCTTTCGTTGTTTTAACCGCACTTCAACGAGGTGTAGTTAAACGAGATGAAATTATTGATACTACGTCCTTTAAATTAAGCGGTAAAGAAATTGTGGACGTTGCACCACGTGCTCAGCAAACTTTAGACGAGATTTTAATGAACTCTAGTAACCGTGGTGTAAGTCGTCTTGCATTACGTATGCCACCTAGTGCATTAATGGAAACTTATCAAAATGCAGGTTTAAGTAAACCGACAGATTTAGGCTTGATCGGAGAGCAAGTTGGGATTTTGAATGCAAATCGTAAACGCTGGGCAGATATTGAGCGTGCAACAGTCGCTTATGGTTATGGTATTACTGCGACACCTTTACAAATTGCTCGTGCCTATGCAACCCTTGGTAGTTTCGGTGTTTATCGTCCGCTTTCTATCACTAAAGTTGATCCGCCAGTTATTGGGAAACGGGTTTTCTCTGAAAAAATAACTAAAGATATTGTGGGAATTTTAGAGAAAGTAGCAATTAAAAATAAACGCGCAATGGTGGAAGGCTACCGTGTCGGCGTAAAAACAGGTACGGCACGTAAGATTGAAAATGGACATTATGTAAATAAGTATGTGGCATTTACTGCGGGTATTGCACCAATTAGTGATCCTCGTTATGCATTAGTGGTTTTGATCAATGATCCAAAAGCAGGAGAATATTATGGTGGTGCGGTTTCTGCCCCTGTATTCTCTAACATTATGGGCTATGCGTTACGTGCAAATGCTATTCCGCAAGATGCTGAAGCAGCTGAAAACACAACAACGAAAAGTGCAAAACGTATTGTTTATATTGGCGAACACAAGAATCAAAAAGTGAATTAA", "partial": "0", "query_start": 219957, "query_end": 221654, "orf_dna_sequence": "ATGAAAGCAGCGCCAAAAACGCCTAAAGCAAAACGTCAGGAAGAACAGGCCAACTTTATCAGTTGGCGTTTTGCGTTGCTGTGCGGCTGTATTCTGCTGGCGCTGGCTTTTCTGCTGGGTCGCGTCGCCTGGCTACAGGTGATCAGCCCCGATATGCTGGTGCGCCAGGGCGATATGCGTTCTCTGCGCGTACAGGAAGTGTCCACCGCGCGCGGGATGATTACCGATCGCTCCGGACGTCCGCTGGCGGTCAGCGTGCCGGTGAAGGCTATCTGGGCCGACCCGAAAGAGCTCCATGACGCCGGCGGGGTTACCCTGGATACGCGCTGGAAAGCGCTGGCGGATGCCCTCAATATGCCGCTGGATCAGCTGGCGACGCGCATCAATACCAATCCGCGGATGCGGTTTATCTATCTGGCGCGTCAGGTTAACCCTGACATGGCCGATTACATCAAGAAGCTGAAGCTGCCGGGCATTCATCTGCGCGAAGAATCCCGTCGGTACTACCCTTCCGGGGAAGTAACCGCTCACCTCATCGGCTTTACCAACGTCGATAGCCAGGGGATTGAAGGGGTTGAAAAAAGCTTTGATAAATGGCTTACCGGTCAGCCGGGCGAGCGTATCGTGCGTAAAGACCGCTATGGCCGGGTAATTGAAGACATCTCTTCTACCGATAGCCAGGCAGCGCACAACCTGGCGCTGAGTATCGACGAACGCCTGCAGGCGCTGGTCTATCGCGAGCTAAACAACGCCGTGGCCTTTAACAAAGCCGAGTCGGGCAGCGCCGTGTTAGTAGATGTTAACACCGGTGAAGTGCTGGCGATGGCCAACAGCCCATCCTATAACCCGAACAACTTCGCCGGTACGGCAAAAGACACCATGCGTAACCGTGCGATTACCGACGTGTTTGAGCCGGGTTCGACGGTGAAACCGATGGTGGTCATGACGGTGCTGCAGCGCGGTATCGTCAACGAAAATACCGTGCTCAATACCGTGCCTTATCGAATTAACGGCCACGAAATCAAAGACGTGGCGCGCTACAGCGAATTGACCCTGACCGGGGTGCTACAGAAGTCGAGTAACGTCGGTGTTTCTAAGCTGGCGTTAGCGATGCCGTCCTCAGCGTTAGTAGATACTTACTCACGTTTTGGGCTTGGAAAGGCGACCAATTTGGGGTTGGTCGGAGAACGCAGTGGCTTATATCCTCAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTTTCTTTCGGCTATGGGCTAATGGTAACCCCGTTACAGTTAGCGCGAGTCTACGCAACGATTGGCAGCTATGGCATCTATCGCCCGTTGTCGATTACCAAAGTTGATCCTCCGGTTCCGGGCGAGCGCGTCTTCCCGGAATCACTCGTTCGTACCGTCGTTCATATGATGGAAAGCGTGGCGCTGCCCGGCGGCGGCGGTGTGAAAGCGGCGATCAAAGGCTATCGCATCGCGATTAAAACCGGTACGGCGAAAAAAGTGGGGCCGGATGGCCGCTATATCAACAAATATATTGCTTACACCGCAGGCGTTGCGCCCGCCAGCCATCCGCGCTTCGCGCTGGTGGTGGTGATCAACGACCCGCAGGCAGGTAAATACTACGGTGGCGCCGTTTCCGCGCCGGTCTTCGGTGCCATCATGGGCGGCGTATTGCGCACCATGAACATCGAGCCGGATGCGCTGGCAACGGGCGAAAAAAGTGAATTTGTAATTAATCAAGGCGAGGGAACAGGTGGCAGATCGTAA", "orf_prot_sequence": "MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTVLQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS", "perc_identity": 52.2}}, "NODE_15_length_100593_cov_44.6763_85 # 89219 # 90610 # 1 # ID=15_85;partial=00;start_type=ATG;rbs_motif=AGGAG;rbs_spacer=5-10bp;gc_cont=0.585": {"gnl|BL_ORD_ID|2191|hsp_num:0": {"type_match": "Strict", "snp": {"original": "E", "change": "Q", "position": 350}, "query_snp": {"original": "E", "change": "Q", "position": 350}, "orf_strand": "+", "orf_start": 89219, "orf_end": 90610, "orf_from": "NODE_15_length_100593_cov_44.6763_85 ", "model_name": "Escherichia coli UhpT with mutation conferring resistance to fosfomycin", "model_type": "protein variant model", "model_type_id": 40293, "model_id": "2373", "pass_evalue": "n/a", "pass_bitscore": 850, "ARO_accession": "3003890", "ARO_name": "Escherichia coli UhpT with mutation conferring resistance to fosfomycin", "ARO_category": {"41412": {"category_aro_accession": "3004248", "category_aro_cvterm_id": "41412", "category_aro_name": "UhpT", "category_aro_description": "UhpT encodes a transporter that can import fosfomycin-type drugs into bacterial cells. Mutations to UhpT confer resistance.", "category_aro_class_name": "AMR Gene Family"}, "35944": {"category_aro_accession": "0000025", "category_aro_cvterm_id": "35944", "category_aro_name": "fosfomycin", "category_aro_description": "Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "max_identities": 440, "bit_score": 864.374, "cvterm_id": "40589", "query": "MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA", "match": "MLAFLNQVRKPTLDLPL+VRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMG+GS SLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLG AEELFGE ISEEDKETE   MTKWQIFVEYVLKNKVIWLLCF+NIFLYVVRIGIDQWSTVYAFQELKLSK VAIQGFTLFE GALVGTLLWGWLSDLANGRR LVACIALALIIATLGVYQHASN+Y+YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALD AA+GCICLMAIVA+ EERKIRREKK + L  A", "sequence_from_db": "MLAFLNQVRKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNEYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTVA", "sequence_from_broadstreet": "MLAFLNQVRKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNEYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTVA", "dna_sequence_from_broadstreet": "ATGCTGGCTTTCTTAAACCAGGTTCGCAAGCCGACCCTGGACCTTCCGCTCGAAGTGCGGCGCAAAATGTGGTTCAAACCGTTCATGCAATCCTACCTGGTGGTCTTTATCGGCTACCTGACGATGTACCTGATTCGCAAGAACTTTAACATCGCGCAGAACGATATGATTTCGACCTACGGGTTGAGCATGACGCAGCTGGGGATGATCGGCCTGGGTTTCTCCATCACTTATGGCGTGGGTAAAACGCTGGTTTCCTACTACGCCGACGGCAAAAACACCAAACAATTCCTGCCGTTCATGCTGATCCTCTCTGCTATTTGTATGCTGGGCTTCAGTGCCAGTATGGGCAGCGGCTCGGTTAGCCTGTTCCTGATGATTGCCTTCTACGCCTTAAGCGGCTTTTTCCAGAGTACCGGCGGTTCGTGCAGTTACTCCACCATCACCAAATGGACGCCGCGTCGTAAACGCGGGACATTCCTCGGTTTCTGGAATATTTCTCACAACCTTGGCGGTGCAGGCGCAGCAGGTGTGGCGCTGTTCGGGGCAAATTACCTGTTCGATGGCCATGTCATCGGCATGTTTATCTTCCCGTCGATTATCGCGCTGATTGTCGGTTTTATCGGCCTGCGTTACGGCAGCGACTCCCCGGAATCTTATGGCCTCGGCAAAGCTGAAGAACTGTTCGGCGAGGAGATCAGCGAAGAGGACAAAGAGACAGAATCTACCGATATGACCAAGTGGCAGATCTTTGTTGAGTATGTGCTGAAAAACAAAGTGATCTGGCTGCTGTGCTTCGCCAACATTTTCCTCTATGTGGTACGTATTGGTATCGACCAGTGGTCAACCGTATACGCGTTCCAGGAACTGAAACTCTCTAAAGCGGTGGCGATTCAGGGCTTTACGCTGTTTGAAGCTGGTGCGCTGGTCGGTACGCTGCTGTGGGGCTGGCTCTCTGACCTGGCGAACGGTCGCCGTGGCCTGGTGGCCTGCATCGCGCTGGCGCTGATTATCGCCACGCTCGGTGTGTATCAACATGCCAGTAACGAATATATCTATCTGGCTTCTCTCTTTGCGTTGGGTTTCCTGGTCTTTGGCCCGCAATTGTTGATTGGTGTGGCTGCTGTTGGCTTTGTACCTAAAAAAGCGATTGGCGCTGCCGATGGTATTAAAGGCACCTTTGCTTACCTGATTGGTGACAGCTTTGCCAAGTTAGGTCTGGGAATGATTGCCGATGGGACGCCGGTATTCGGCCTTACCGGCTGGGCAGGCACCTTCGCCGCGCTGGATATCGCCGCGATTGGTTGTATCTGCCTGATGGCGATAGTGGCGGTAATGGAAGAACGCAAAATCCGCCGCGAGAAAAAAATTCAGCAGTTGACAGTGGCATAA", "partial": "0", "query_start": 89219, "query_end": 90607, "orf_dna_sequence": "ATGCTGGCCTTTCTGAATCAGGTGCGCAAGCCGACCTTGGATCTGCCGCTCGATGTGCGGCGCAAAATGTGGTTCAAACCTTTCATGCAGTCCTATCTGGTGGTTTTCATCGGCTACCTGACCATGTACTTGATCCGCAAGAACTTTAACATCGCGCAGAACGACATGATCTCCACCTACGGGCTGAGCATGACCCAGCTGGGGATGATTGGCCTGGGCTTCTCCATCACCTACGGCGTGGGCAAGACGCTGGTCTCTTATTATGCCGACGGCAAAAACACCAAGCAGTTCCTGCCGTTTATGCTGATCCTCTCCGCCATCTGTATGCTGGGCTTTAGCGCCAGCATGGGGGCGGGTTCTACCAGCCTGTTCCTGATGATCGCCTTCTATGCGCTGAGCGGTTTCTTCCAGAGCACCGGCGGCTCGTGCAGCTATTCCACCATCACCAAGTGGACGCCCAGACGCAAACGCGGCACTTTCCTCGGCTTCTGGAATATCTCCCACAACCTCGGCGGCGCGGGCGCGGCGGGCGTGGCGCTGTTTGGCGCCAACTATCTGTTCGACGGCCATGTGATCGGCATGTTTATCTTCCCGTCGATTATTGCGCTGATCGTTGGCTTTATCGGCCTGCGCTACGGTAGCGACTCTCCGGAATCCTACGGCCTCGGCACGGCGGAAGAGCTGTTTGGCGAAGCGATCAGCGAAGAGGACAAAGAGACCGAAGAAAATGCGATGACCAAGTGGCAGATCTTTGTTGAGTACGTGCTGAAAAACAAAGTGATCTGGCTGCTGTGCTTCTCCAACATCTTCCTCTACGTGGTGCGTATCGGTATCGATCAGTGGTCCACCGTGTACGCCTTCCAGGAGCTGAAGCTGTCGAAAGAGGTGGCGATTCAGGGCTTTACCCTGTTTGAGGTCGGCGCGCTGGTCGGCACGCTGCTGTGGGGCTGGCTGTCGGATCTGGCCAACGGCCGCCGCGCGCTGGTGGCCTGCATCGCGCTGGCGCTGATTATCGCCACCCTCGGGGTTTACCAACACGCCAGCAACCAGTACGTCTATCTGGCCTCGTTATTTGCGCTGGGCTTCCTGGTGTTTGGTCCGCAGCTGTTGATCGGCGTCGCCGCCGTCGGTTTCGTACCGAAAAAAGCGATCGGCGCCGCCGATGGGATCAAGGGCACCTTCGCCTATCTGATCGGCGATAGCTTCGCCAAACTGGGTCTCGGGATGATCGCCGACGGCACCCCGGTCTTCGGCCTGACCGGCTGGGCCGGCACCTTTGCGGCGCTGGACGCCGCCGCCGTCGGCTGTATCTGCCTGATGGCCATCGTGGCTATCTTTGAAGAGCGTAAAATTCGCCGCGAGAAAAAGAACCGTATTTTGCAGACCGCCTGA", "orf_prot_sequence": "MLAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQTA", "perc_identity": 95.03}}, "NODE_59_length_1013_cov_103.874_1 # 1 # 1011 # 1 # ID=59_1;partial=11;start_type=Edge;rbs_motif=None;rbs_spacer=None;gc_cont=0.547": {"gnl|BL_ORD_ID|2022|hsp_num:0": {"type_match": "Strict", "snp": {"original": "R", "change": "F", "position": 234}, "query_snp": {"original": "R", "change": "F", "position": 176}, "orf_strand": "+", "orf_start": 1, "orf_end": 1011, "orf_from": "NODE_59_length_1013_cov_103.874_1 ", "model_name": "Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin", "model_type": "protein variant model", "model_type_id": 40293, "pass_evalue": "n/a", "pass_bitscore": 700, "model_id": "2158", "ARO_accession": "3003369", "ARO_name": "Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin", "ARO_category": {"37711": {"category_aro_accession": "3001312", "category_aro_cvterm_id": "37711", "category_aro_name": "elfamycin resistant EF-Tu", "category_aro_description": "Sequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics.", "category_aro_class_name": "AMR Gene Family"}, "36725": {"category_aro_accession": "3000586", "category_aro_cvterm_id": "36725", "category_aro_name": "pulvomycin", "category_aro_description": "Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance.", "category_aro_class_name": "Antibiotic"}, "37618": {"category_aro_accession": "3001219", "category_aro_cvterm_id": "37618", "category_aro_name": "elfamycin antibiotic", "category_aro_description": "Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP.", "category_aro_class_name": "Drug Class"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 0.0, "bit_score": 676.396, "max_identities": 331, "cvterm_id": "36763", "query": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKIIELAGHLDTYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETAKTTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTINPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "match": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKI+ELAG LD+YIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKET K+TCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTI PHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "sequence_from_db": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "sequence_from_broadstreet": "MLSPEGESTIVRNIAVSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG", "dna_sequence_from_broadstreet": "GTGCTCTCTCCTGAAGGGGAGAGCACTATAGTAAGGAATATAGCCGTGTCTAAAGAAAAATTTGAACGTACAAAACCGCACGTTAACGTTGGTACTATCGGCCACGTTGACCACGGTAAAACTACTCTGACCGCTGCAATCACCACCGTACTGGCTAAAACCTACGGCGGTGCTGCTCGTGCATTCGACCAGATCGATAACGCGCCGGAAGAAAAAGCTCGTGGTATCACCATCAACACTTCTCACGTTGAATACGACACCCCGACCCGTCACTACGCGCACGTAGACTGCCCGGGGCACGCCGACTATGTTAAAAACATGATCACCGGTGCTGCTCAGATGGACGGCGCGATCCTGGTAGTTGCTGCGACTGACGGCCCGATGCCGCAGACTCGTGAGCACATCCTGCTGGGTCGTCAGGTAGGCGTTCCGTACATCATCGTGTTCCTGAACAAATGCGACATGGTTGATGACGAAGAGCTGCTGGAACTGGTTGAAATGGAAGTTCGTGAACTTCTGTCTCAGTACGACTTCCCGGGCGACGACACTCCGATCGTTCGTGGTTCTGCTCTGAAAGCGCTGGAAGGCGACGCAGAGTGGGAAGCGAAAATCCTGGAACTGGCTGGCTTCCTGGATTCTTACATTCCGGAACCAGAGCGTGCGATTGACAAGCCGTTCCTGCTGCCGATCGAAGACGTATTCTCCATCTCCGGTCGTGGTACCGTTGTTACCGGTCGTGTAGAACGCGGTATCATCAAAGTTGGTGAAGAAGTTGAAATCGTTGGTATCAAAGAGACTCAGAAGTCTACCTGTACTGGCGTTGAAATGTTCCGCAAACTGCTGGACGAAGGCCGTGCTGGTGAGAACGTAGGTGTTCTGCTGCGTGGTATCAAACGTGAAGAAATCGAACGTGGTCAGGTACTGGCTAAGCCGGGCACCATCAAGCCGCACACCAAGTTCGAATCTGAAGTGTACATTCTGTCCAAAGATGAAGGCGGTCGTCATACTCCGTTCTTCAAAGGCTACCGTCCGCAGTTCTACTTCCGTACTACTGACGTGACTGGTACCATCGAACTGCCGGAAGGCGTAGAGATGGTAATGCCGGGCGACAACATCAAAATGGTTGTTACCCTGATCCACCCGATCGCGATGGACGACGGTCTGCGTTTCGCAATCCGTGAAGGCGGCCGTACCGTTGGCGCGGGCGTTGTTGCTAAAGTTCTGGGCTAA", "partial": "0", "query_start": 1, "query_end": 1011, "orf_dna_sequence": "GCTCGCGCATTCGACCAGATCGATAACGCGCCGGAAGAAAAAGCTCGTGGTATCACCATCAACACCTCTCACGTTGAATATGACACCCCGACTCGCCACTACGCGCACGTAGACTGCCCGGGCCACGCCGACTATGTTAAAAACATGATCACCGGTGCTGCGCAGATGGACGGCGCGATCCTGGTTGTTGCTGCGACTGACGGCCCGATGCCGCAGACTCGTGAGCACATCCTGCTGGGTCGTCAGGTAGGCGTTCCGTACATCATCGTGTTCCTGAACAAATGCGACATGGTTGATGACGAAGAGCTGCTGGAACTGGTTGAGATGGAAGTTCGTGAACTGCTGTCTCAGTACGATTTCCCGGGCGACGACACCCCGATCGTTCGTGGTTCTGCTCTGAAAGCGCTGGAAGGCGACGCAGAGTGGGAAGCGAAAATCATCGAACTGGCTGGCCACCTGGATACCTATATCCCGGAACCAGAGCGTGCGATTGACAAGCCGTTCCTGCTGCCGATCGAAGACGTATTCTCCATCTCTGGTCGTGGTACCGTTGTTACCGGTCGTGTAGAGCGCGGTATCATCAAAGTAGGTGAAGAAGTTGAAATCGTTGGTATCAAAGAAACCGCGAAAACCACCTGTACTGGCGTTGAAATGTTCCGCAAACTGCTGGACGAAGGCCGTGCTGGTGAGAACGTAGGTGTTCTGCTGCGTGGTATCAAACGTGAAGAAATCGAACGTGGTCAGGTACTGGCTAAGCCGGGCACCATCAACCCGCACACCAAGTTCGAATCTGAAGTGTACATCCTGTCCAAAGATGAAGGCGGCCGTCACACTCCGTTCTTCAAAGGCTACCGTCCGCAGTTCTACTTCCGTACTACTGACGTGACTGGCACCATCGAACTGCCGGAAGGCGTAGAGATGGTAATGCCGGGCGACAACATCAAAATGGTTGTTACCCTGATCCACCCGATCGCGATGGACGACGGTCTGCGTTTCGCAATCCGTGAAGGC", "orf_prot_sequence": "ARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKIIELAGHLDTYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETAKTTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTINPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREG", "perc_identity": 98.22, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}}, "NODE_11_length_157792_cov_39.2115_111 # 107958 # 108392 # 1 # ID=11_111;partial=00;start_type=ATG;rbs_motif=None;rbs_spacer=None;gc_cont=0.545": {"gnl|BL_ORD_ID|2040|hsp_num:0": {"type_match": "Strict", "orf_strand": "+", "orf_start": 107958, "orf_end": 108392, "orf_from": "NODE_11_length_157792_cov_39.2115_111", "model_name": "Escherichia coli marR mutant conferring antibiotic resistance", "model_type": "protein overexpression model", "model_type_id": 41091, "model_id": "431", "pass_evalue": "n/a", "pass_bitscore": "210", "ARO_accession": "3003378", "ARO_name": "Escherichia coli marR mutant conferring antibiotic resistance", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 8.24177e-89, "bit_score": 251.906, "max_identities": 120, "cvterm_id": "36849", "query": "MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLACKGWIKRLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP", "match": "MKSTSDLFNE+IPLGRLI MVNQKKDRLLN+YLSP+DITA QF+VLCSIRC  CITPVELK VLSVD GA+TRMLDRL CKGW++RLPNP DKRGVLV+LT  GAA+CEQCHQ+VGQ LHQELTKNL+ADEVA LE LLKKVLP", "sequence_from_db": "MKSTSDLFNEIIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP", "sequence_from_broadstreet": "MKSTSDLFNEIIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP", "dna_sequence_from_broadstreet": "GTGAAAAGTACCAGCGATCTGTTCAATGAAATTATTCCATTGGGTCGCTTAATCCATATGGTTAATCAGAAGAAAGATCGCCTGCTTAACGAGTATCTGTCTCCGCTGGATATTACCGCGGCACAGTTTAAGGTGCTCTGCTCTATCCGCTGCGCGGCGTGTATTACTCCGGTTGAACTGAAAAAGGTATTGTCGGTCGACCTGGGAGCACTGACCCGTATGCTGGATCGCCTGGTCTGTAAAGGCTGGGTGGAAAGGTTGCCGAACCCGAATGACAAGCGCGGCGTACTGGTAAAACTTACCACCGGCGGCGCGGCAATATGTGAACAATGCCATCAATTAGTTGGCCAGGACCTGCACCAAGAATTAACAAAAAACCTGACGGCGGACGAAGTGGCAACACTTGAGTATTTGCTTAAGAAAGTCCTGCCGTAA", "partial": "0", "query_start": 107958, "query_end": 108389, "orf_dna_sequence": "ATGAAAAGTACCAGCGACCTGTTTAATGAAATGATCCCGCTGGGTCGCTTGATCCAGATGGTTAACCAGAAAAAAGATCGCCTGCTCAATGACTACCTCTCACCTATGGATATTACCGCGACCCAGTTTCGCGTGCTCTGCTCCATTCGTTGCGAAGTATGTATTACCCCCGTTGAGCTGAAAACCGTGCTTTCCGTCGACCCGGGCGCAATGACGCGCATGCTCGACCGCCTGGCGTGCAAAGGCTGGATTAAACGGTTACCCAACCCCGCTGACAAGCGCGGCGTGCTGGTGCAGTTGACGCCGGACGGCGCAGCCCTTTGCGAGCAGTGTCATCAGGTTGTGGGTCAGAAGTTACACCAGGAGTTAACGAAAAATCTGTCGGCGGACGAAGTCGCCATGCTTGAGCAACTGCTCAAGAAGGTCCTGCCGTAA", "orf_prot_sequence": "MKSTSDLFNEMIPLGRLIQMVNQKKDRLLNDYLSPMDITATQFRVLCSIRCEVCITPVELKTVLSVDPGAMTRMLDRLACKGWIKRLPNPADKRGVLVQLTPDGAALCEQCHQVVGQKLHQELTKNLSADEVAMLEQLLKKVLP", "perc_identity": 83.33}}, "NODE_152_length_397_cov_0.740741_1 # 1 # 270 # -1 # ID=152_1;partial=10;start_type=ATG;rbs_motif=GGA/GAG/AGG;rbs_spacer=5-10bp;gc_cont=0.637": {"gnl|BL_ORD_ID|2412|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Type B NfxB", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "310", "model_id": "2693", "ARO_accession": "3004060", "ARO_name": "Type B NfxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35933": {"category_aro_accession": "0000014", "category_aro_cvterm_id": "35933", "category_aro_name": "gentamicin C", "category_aro_description": "Gentamicin C is a mixture of gentamicin C1, gentamicin C1a, and gentamicin C2 (these differ in substituents at position C6'). Gentamicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35935": {"category_aro_accession": "0000016", "category_aro_cvterm_id": "35935", "category_aro_name": "aminoglycoside antibiotic", "category_aro_description": "Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.91668e-62, "max_identities": 90, "bit_score": 182.956, "cvterm_id": "36804", "query": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "match": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_db": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_broadstreet": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS", "dna_sequence_from_broadstreet": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA", "partial": "0", "query_start": 1, "query_end": 270, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2410|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Type A NfxB", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "310", "model_id": "2691", "ARO_accession": "3004059", "ARO_name": "Type A NfxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.91668e-62, "max_identities": 90, "bit_score": 182.956, "cvterm_id": "36804", "query": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "match": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_db": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_broadstreet": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS", "dna_sequence_from_broadstreet": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA", "partial": "0", "query_start": 1, "query_end": 270, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2409|hsp_num:0": {"type_match": "Strict", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Type A NfxB", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "310", "model_id": "2691", "ARO_accession": "3004059", "ARO_name": "Type A NfxB", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35925": {"category_aro_accession": "0000006", "category_aro_cvterm_id": "35925", "category_aro_name": "erythromycin", "category_aro_description": "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36250": {"category_aro_accession": "3000111", "category_aro_cvterm_id": "36250", "category_aro_name": "novobiocin", "category_aro_description": "Novobiocin is an aminocoumarin antibiotic produced by Streptomyces spheroides and Streptomyces niveus, and binds DNA gyrase subunit B inhibiting ATP-dependent DNA supercoiling.", "category_aro_class_name": "Antibiotic"}, "36327": {"category_aro_accession": "3000188", "category_aro_cvterm_id": "36327", "category_aro_name": "trimethoprim", "category_aro_description": "Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "37007": {"category_aro_accession": "3000663", "category_aro_cvterm_id": "37007", "category_aro_name": "ofloxacin", "category_aro_description": "Ofloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.", "category_aro_class_name": "Antibiotic"}, "35919": {"category_aro_accession": "0000000", "category_aro_cvterm_id": "35919", "category_aro_name": "macrolide antibiotic", "category_aro_description": "Macrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.", "category_aro_class_name": "Drug Class"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36242": {"category_aro_accession": "3000103", "category_aro_cvterm_id": "36242", "category_aro_name": "aminocoumarin antibiotic", "category_aro_description": "Aminocoumarin antibiotics bind DNA gyrase subunit B to inhibit ATP-dependent DNA supercoiling.", "category_aro_class_name": "Drug Class"}, "36310": {"category_aro_accession": "3000171", "category_aro_cvterm_id": "36310", "category_aro_name": "diaminopyrimidine antibiotic", "category_aro_description": "Diaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups.  They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 5.91668e-62, "max_identities": 90, "bit_score": 182.956, "cvterm_id": "36804", "query": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "match": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_db": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "sequence_from_broadstreet": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYGMVDAERRGRAASSNSAHTLEQMFLHGASNPARS", "dna_sequence_from_broadstreet": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCGCGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCACCGCGAGCTGCTGGTATTCCTGGTATTCCAGTACCGCCCGGACTTCCTCGACCCGCACGGCGAAGGCGCACGCTGGCAGTCCTACCTGGAAGCGCTGGACGCCTTCTTCCTGCGCGGACAGCAGAAAGGCGTGTTTCGCATCGACATCACGGCGGCCGTGTTCACCGAACTGTTCATCACCCTGGTCTACGGCATGGTCGATGCGGAACGTCGCGGACGGGCGGCCAGCTCCAATTCCGCGCATACCCTGGAGCAGATGTTCCTCCATGGCGCCTCCAATCCGGCTCGCTCCTGA", "partial": "0", "query_start": 1, "query_end": 270, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 100.0, "nudged": true, "note": "loose hit with at least 95 percent identity pushed strict"}, "gnl|BL_ORD_ID|2149|hsp_num:0": {"type_match": "Loose", "orf_strand": "-", "orf_start": 1, "orf_end": 270, "orf_from": "NODE_152_length_397_cov_0.740741_1 ", "model_name": "Escherichia coli acrR with mutation conferring multidrug antibiotic resistance", "model_type": "protein overexpression model", "model_type_id": 41091, "pass_evalue": "n/a", "pass_bitscore": "375", "model_id": "2306", "ARO_accession": "3003807", "ARO_name": "Escherichia coli acrR with mutation conferring multidrug antibiotic resistance", "ARO_category": {"36005": {"category_aro_accession": "0010004", "category_aro_cvterm_id": "36005", "category_aro_name": "resistance-nodulation-cell division (RND) antibiotic efflux pump", "category_aro_description": "Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.", "category_aro_class_name": "AMR Gene Family"}, "35949": {"category_aro_accession": "0000030", "category_aro_cvterm_id": "35949", "category_aro_name": "tigecycline", "category_aro_description": "Tigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "35968": {"category_aro_accession": "0000051", "category_aro_cvterm_id": "35968", "category_aro_name": "tetracycline", "category_aro_description": "Tetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.", "category_aro_class_name": "Antibiotic"}, "36308": {"category_aro_accession": "3000169", "category_aro_cvterm_id": "36308", "category_aro_name": "rifampin", "category_aro_description": "Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.", "category_aro_class_name": "Antibiotic"}, "36524": {"category_aro_accession": "3000385", "category_aro_cvterm_id": "36524", "category_aro_name": "chloramphenicol", "category_aro_description": "Chloramphenicol is a bacteriostatic antimicrobial originally derived from the bacterium Streptomyces venezuelae. It was the first antibiotic to be manufactured synthetically on a large scale. It functions by inhibiting peptidyl transferase activity of the bacterial ribosome, binding to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit and preventing peptide bond formation.", "category_aro_class_name": "Antibiotic"}, "36981": {"category_aro_accession": "3000637", "category_aro_cvterm_id": "36981", "category_aro_name": "ampicillin", "category_aro_description": "Ampicillin is a penicillin derivative that is highly acid stable, with its activity similar to benzylpenicillin.", "category_aro_class_name": "Antibiotic"}, "37084": {"category_aro_accession": "3000704", "category_aro_cvterm_id": "37084", "category_aro_name": "cefalotin", "category_aro_description": "Cefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.", "category_aro_class_name": "Antibiotic"}, "35920": {"category_aro_accession": "0000001", "category_aro_cvterm_id": "35920", "category_aro_name": "fluoroquinolone antibiotic", "category_aro_description": "The fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.", "category_aro_class_name": "Drug Class"}, "35951": {"category_aro_accession": "0000032", "category_aro_cvterm_id": "35951", "category_aro_name": "cephalosporin", "category_aro_description": "Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.", "category_aro_class_name": "Drug Class"}, "35960": {"category_aro_accession": "0000042", "category_aro_cvterm_id": "35960", "category_aro_name": "glycylcycline", "category_aro_description": "Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.", "category_aro_class_name": "Drug Class"}, "36017": {"category_aro_accession": "3000008", "category_aro_cvterm_id": "36017", "category_aro_name": "penam", "category_aro_description": "Penams, often referred to as penicillins, are a group of antibiotics derived from Penicillium fungi. Penicillin antibiotics are historically significant because they are the first drugs that were effective against many previously serious diseases such as syphilis and Staphylococcus infections. Penicillins are still widely used today, though many types of bacteria are now resistant. All penicillins are beta-lactam antibiotics in the penam sub-group, and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms.", "category_aro_class_name": "Drug Class"}, "36189": {"category_aro_accession": "3000050", "category_aro_cvterm_id": "36189", "category_aro_name": "tetracycline antibiotic", "category_aro_description": "These antibiotics are derived from tetracycline, a polyketide antibiotic that inhibits the 30S subunit of bacterial ribosomes.", "category_aro_class_name": "Drug Class"}, "36296": {"category_aro_accession": "3000157", "category_aro_cvterm_id": "36296", "category_aro_name": "rifamycin antibiotic", "category_aro_description": "Rifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.", "category_aro_class_name": "Drug Class"}, "36526": {"category_aro_accession": "3000387", "category_aro_cvterm_id": "36526", "category_aro_name": "phenicol antibiotic", "category_aro_description": "Phenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.", "category_aro_class_name": "Drug Class"}, "37250": {"category_aro_accession": "3000870", "category_aro_cvterm_id": "37250", "category_aro_name": "triclosan", "category_aro_description": "Triclosan is a common antibacterial agent added to many consumer products as a biocide.  It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).", "category_aro_class_name": "Drug Class"}, "36298": {"category_aro_accession": "3000159", "category_aro_cvterm_id": "36298", "category_aro_name": "efflux pump complex or subunit conferring antibiotic resistance", "category_aro_description": "Efflux proteins that pump antibiotic out of a cell to confer resistance.", "category_aro_class_name": "Efflux Component"}, "36590": {"category_aro_accession": "3000451", "category_aro_cvterm_id": "36590", "category_aro_name": "protein(s) and two-component regulatory system modulating antibiotic efflux", "category_aro_description": "Protein(s) and two component regulatory systems that directly or indirectly change rates of antibiotic efflux.", "category_aro_class_name": "Efflux Regulator"}, "35997": {"category_aro_accession": "0001001", "category_aro_cvterm_id": "35997", "category_aro_name": "antibiotic target alteration", "category_aro_description": "Mutational alteration or enzymatic modification of antibiotic target which results in antibiotic resistance.", "category_aro_class_name": "Resistance Mechanism"}, "36001": {"category_aro_accession": "0010000", "category_aro_cvterm_id": "36001", "category_aro_name": "antibiotic efflux", "category_aro_description": "Antibiotic resistance via the transport of antibiotics out of the cell.", "category_aro_class_name": "Resistance Mechanism"}}, "evalue": 2.11739, "max_identities": 14, "bit_score": 23.483, "cvterm_id": "36849", "query": "TLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEH-----AEPLEALQRLI", "match": "+L E+A+AAGV++  ++     + +L   + +  E+ + ++    +LE+      +PL  L+ ++", "sequence_from_db": "SLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGEL----ELEYQAKFPGDPLSVLREIL", "sequence_from_broadstreet": "MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE", "dna_sequence_from_broadstreet": "ATGGCACGAAAAACCAAACAAGAAGCGCAAGAAACGCGCCAACACATCCTCGATGTGGCTCTACGTCTTTTCTCACAGCAGGGGGTATCATCCACCTCGCTGGGCGAGATTGCAAAAGCAGCTGGCGTTACGCGCGGTGCAATCTACTGGCATTTTAAAGACAAGTCGGATTTGTTCAGTGAGATCTGGGAACTGTCAGAATCCAATATTGGTGAACTAGAGCTTGAGTATCAGGCAAAATTCCCTGGCGATCCACTCTCAGTATTAAGAGAGATATTAATTCATGTTCTTGAATCCACGGTGACAGAAGAACGGCGTCGATTATTGATGGAGATTATATTCCACAAATGCGAATTTGTCGGAGAAATGGCTGTTGTGCAACAGGCACAACGTAATCTCTGTCTGGAAAGTTATGACCGTATAGAACAAACGTTAAAACATTGTATTGAAGCGAAAATGTTGCCTGCGGATTTAATGACGCGTCGCGCAGCAATTATTATGCGCGGCTATATTTCCGGCCTGATGGAAAACTGGCTCTTTGCCCCGCAATCTTTTGATCTTAAAAAAGAAGCCCGCGATTACGTTGCCATCTTACTGGAGATGTATCTCCTGTGCCCCACGCTTCGTAATCCTGCCACTAACGAATAA", "partial": "0", "query_start": 73, "query_end": 252, "orf_dna_sequence": "ATGACCCTGATTTCCCATGACGAGCGACTCATCAAGGCGCTGGCAGTCGCTATCGTCGACCGCCCACGAGCGACGCTGAAGGAACTGGCCGAGGCGGCCGGCGTAAGCAAGGCCACCCTGCACCGCTTCTGCGGCACGCGGGACAACCTGGTGCAGATGCTCGAGGACCACGGAGAGACCGTACTGAACCAGATCATCCAGGCCTGCGACCTGGAGCATGCCGAGCCTCTGGAGGCGTTGCAGCGCCTGATCAAGGAACACCTCACCCAC", "orf_prot_sequence": "MTLISHDERLIKALAVAIVDRPRATLKELAEAAGVSKATLHRFCGTRDNLVQMLEDHGETVLNQIIQACDLEHAEPLEALQRLIKEHLTH", "perc_identity": 21.54}}}
\ No newline at end of file
--- a/test-data/summary.json	Tue Mar 16 12:38:42 2021 +0000
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,1 +0,0 @@
-[{"input_file_name":"GCF_010120755.1_ASM1012075v1_genomic","gene_symbol":"aacA-ENT1","gene_name":"aminoglycoside 6'-N-acetyltransferase","reference_database_id":"ncbi","reference_database_version":"db_v_1","reference_accession":"NG_052371.1","analysis_software_name":"abricate","analysis_software_version":"tool_v_1","sequence_identity":100.0,"input_sequence_id":"NZ_CP039729.1","input_protein_start":"","input_protein_stop":"","input_gene_start":2163439,"input_gene_stop":2163987,"reference_protein_start":"","reference_protein_stop":"","reference_gene_start":"","reference_gene_stop":"","strand_orientation":"-","coverage_depth":"","coverage_percentage":100.0,"coverage_ratio":"","reference_gene_length":"","reference_protein_length":"","input_gene_length":"","input_protein_length":"","drug_class":"AMINOGLYCOSIDE","antimicrobial_agent":"","resistance_mechanism":""},{"input_file_name":"GCF_010120755.1_ASM1012075v1_genomic","gene_symbol":"aacA-ENT1","gene_name":"aminoglycoside 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\ No newline at end of file