--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/humann2_rna_dna_norm.xml	Tue Aug 01 07:56:14 2017 -0400
@@ -0,0 +1,73 @@
+<tool id="humann2_rna_dna_norm" name="Normalize" version="@WRAPPER_VERSION@.0">
+    <description> combined meta'omic sequencing data</description>
+    <macros>
+        <import>humann2_macros.xml</import>
+    </macros>
+    <expand macro="requirements"/>
+    <expand macro="version"/>
+    <command detect_errors="exit_code"><![CDATA[
+humann2_rna_dna_norm
+    --input_dna '$input_dna'
+    --input_rna '$input_rna'
+    --output_basename 'results'
+    --method '$method'
+    #if $log.log_transform == 'yes'
+        --log_transform
+        --log_base $log.log_base
+    #end if
+    ]]></command>
+    <inputs>
+        <param argument="--input_dna" type="data" format="tsv,tabular,biom1" label="Original DNA output table"/>
+        <param argument="--input_rna" type="data" format="tsv,tabular,biom1" label="Original RNA output table"/>
+        <param argument="--method" type="select" label="Choice of smoothing method">
+            <option value="laplace">Laplace</option>
+            <option value="witten_bell">Witten-Bell</option>
+        </param>
+        <conditional name="log">
+            <param argument="--log_transform" type="select" label="Report log-transformed relative expression values?">
+                <option value="yes">Yes</option>
+                <option value="no">No</option>
+            </param>
+            <when value="yes">
+                <param argument="--log_base" type="integer" value="2" label="Base for log transformation"/>
+            </when>
+            <when value="no"/>
+        </conditional>
+    </inputs>
+    <outputs>
+        <data format="tsv" name="results-relative_expression" from_work_dir="results-relative_expression.tsv" label="${tool.name} on ${on_string}: normalized RNA"/>
+        <data format="tsv" name="results-smoothed_dna" from_work_dir="results-smoothed_dna.tsv" label="${tool.name} on ${on_string}: smoothed DNA"/>
+        <data format="tsv" name="results-smoothed_rna" from_work_dir="results-smoothed_rna.tsv" label="${tool.name} on ${on_string}: smoothed RNA"/>
+    </outputs>
+    <tests>
+        <test>
+            <param name="input_dna" value="rna_dna_norm-dna.txt"/>
+            <param name="input_rna" value="rna_dna_norm-rna.txt"/>
+            <param name="method" value="laplace"/>
+            <conditional name="log">
+                <param name="log_transform" value="no"/>
+            </conditional>
+            <output name="results-relative_expression" md5="193000abf357cb14f70273ba6cd5f095"/>
+            <output name="results-smoothed_dna" md5="3767aa13988a4dca40a07cb6970bcc60"/>
+            <output name="results-smoothed_rna" md5="8b1bcb819c31ef0ba5ab4975582bfcf7"/>
+        </test>
+        <test>
+            <param name="input_dna" value="rna_dna_norm-dna.txt"/>
+            <param name="input_rna" value="rna_dna_norm-rna.txt"/>
+            <param name="method" value="witten_bell"/>
+            <conditional name="log">
+                <param name="log_transform" value="yes"/>
+                <param name="log_base" value="2"/>
+            </conditional>
+            <output name="results-relative_expression" md5="3064e6377c074c6e6e9cf7fdfd466ec9"/>
+            <output name="results-smoothed_dna" md5="3a1203c0986d79e9cb4ac0e3a4a89f4e"/>
+            <output name="results-smoothed_rna" md5="1038b44e52b95a867dc6341b4dd91697"/>
+        </test>
+    </tests>
+    <help><![CDATA[
+@HELP_HEADER@
+
+Given a DNA table and a RNA table, produce smoothed RNA and DNA values as well as relative expression values. "Smoothing" means substituting a small value in place of a zero or missing value. The default method used is "Laplace" (pseudocount) scaling, where the pseudocount is the sample-specific minimum non-zero value. (Witten-Bell smoothing is also implemented.)
+    ]]></help>
+    <expand macro="citations"/>
+</tool>