Mercurial > repos > iuc > hyphy_absrel
diff hyphy_absrel.xml @ 6:f73435dc282b draft
"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hyphy/ commit 8d5ae1d04c43988fdcc458f4f08376a15e72db8e"
author | iuc |
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date | Thu, 20 Feb 2020 18:17:51 -0500 |
parents | 181f5b9f139f |
children | cce7b18495e4 |
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--- a/hyphy_absrel.xml Mon Feb 17 14:51:50 2020 -0500 +++ b/hyphy_absrel.xml Thu Feb 20 18:17:51 2020 -0500 @@ -39,11 +39,77 @@ </test> </tests> <help><![CDATA[ -aBSREL (Adaptive branch-site random effects likelihood) uses an adaptive random effects branch-site model framework to test whether each branch has evolved under positive selection, using a procedure which infers an optimal number of rate categories per branch. + +aBSREL : Adaptive Branch-Site Random Effects Likelihood +======================================================= + +What question does this method answer? +-------------------------------------- + +Is some proportion of sites is subject to positive selection along specific branches or lineages of a phylogeny? + +Recommended Applications +------------------------ + +1. Exploratory testing for evidence of lineage-specific positive diversifying selection in small to medium sized alignments (up to 100 sequences). +2. Targeted testing of branches selected a priori for positive diversifying selection, including alignments with prohibitive runtimes under older branch-site models (up to 1,000 sequences) + +Brief description +----------------- + +aBSREL (Adaptive branch-site random effects likelihood) uses an adaptive +random effects branch-site model framework to test whether each branch +has evolved under positive selection, using a procedure which infers an +optimal number of rate categories per branch. + + +Input +----- + +1. A *FASTA* sequence alignment. +2. A phylogenetic tree in the *Newick* format + +Note: the names of sequences in the alignment must match the names of the sequences in the tree. + + +Output +------ -See the online documentation_ for more information. +A JSON file with analysis results (http://hyphy.org/resources/json-fields.pdf). + +For each tested branch the analysis will infer the appropriate number of selective regimes, +and whether or not there is statistical evidence of positive selection on that branch. + +A custom visualization module for viewing these results is available (see http://vision.hyphy.org/aBSREL for an example) + +Further reading +--------------- + +http://hyphy.org/methods/selection-methods/#absrel + + +Tool options +------------ +:: + -.. _documentation: http://hyphy.org/methods/selection-methods/#absrel + --code Which genetic code to use + + --branches Which branches should be tested for selection? + All [default] : test all branches + + Internal : test only internal branches (suitable for + intra-host pathogen evolution for example, where terminal branches + may contain polymorphism data) + + Leaves: test only terminal (leaf) branches + + Unlabeled: if the Newick string is labeled using the {} notation, + test only branches without explicit labels + (see http://hyphy.org/tutorials/phylotree/) + + + ]]></help> <expand macro="citations"> <citation type="doi">10.1093/molbev/msv022</citation>