Mercurial > repos > iuc > hyphy_prime

annotate hyphy_prime.xml @ 4:e06961ac014b draft

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"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hyphy/ commit 2413d0043c5d263ecfa75ec0f8614e322fb65f99"
author iuc
date Fri, 08 May 2020 18:45:52 -0400
parents 8f66e659530b
children 1d9d3c6bc246
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1 <?xml version="1.0"?>
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2 <tool id="hyphy_prime" name="HyPhy-PRIME" version="@VERSION@+galaxy0">
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3 <description>Property Informed Models of Evolution</description>
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4 <macros>
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5 <import>macros.xml</import>
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6 </macros>
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7 <expand macro="requirements"/>
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8 <command detect_errors="exit_code"><![CDATA[
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9 ln -s '$input_file' prime_input.fa &&
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10 ln -s '$input_nhx' prime_input.nhx &&
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11 @HYPHYMPI@ prime
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12 --alignment ./prime_input.fa
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13 --tree ./prime_input.nhx
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14 --code '$gencodeid'
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15 --branches '$branches'
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16 --pvalue '$p_value'
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17 --properties '$prop_set'
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18 --output '$prime_output'
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19 > '$prime_log'
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20 ;
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21 @CATCH_MPIERR@
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22 ]]></command>
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23 <inputs>
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24 <expand macro="inputs"/>
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25 <expand macro="gencode"/>
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26 <expand macro="branches"/>
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27 <param name="prop_set" type="select" label="Biochemical properties to use">
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28 <option value="Atchley">Atchley</option>
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29 <option value="LCAP">LCAP</option>
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30 </param>
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31 <param name="p_value" type="float" value=".1" min="0" max="1" label="P-value threshold"/>
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32 </inputs>
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33 <outputs>
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34 <data name="prime_log" format="txt"/>
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35 <data name="prime_output" format="hyphy_results.json" />
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36 </outputs>
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37 <tests>
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38 <test>
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39 <param name="input_file" ftype="fasta" value="prime-in1.fa"/>
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40 <param name="input_nhx" ftype="nhx" value="prime-in1.nhx"/>
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41 <param name="branches" value="All"/>
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42 <param name="p_value" value="0.1"/>
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43 <param name="prop_set" value="Atchley"/>
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44 <output name="prime_output" file="prime-out1.json" compare="sim_size"/>
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45 </test>
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46 </tests>
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47 <help><![CDATA[
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48 PRIME: Property Informed Model of Evolution
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49 ===========================================
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50
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51 What question does this method answer?
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52 --------------------------------------
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53
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54 Does evolution at specific sites in a coding alignment preserve or alter some biochemical properties?
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55
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56 Recommended Applications
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57 ------------------------
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58
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59 Identify biochemical evolutionary constraints or changes with site level resolution: e.g. site 23 is
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60 evolving to conserve residue polarity, but alter it's volume.
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61
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62
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63 Brief description
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64 -----------------
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65
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66 Most methods of coding sequence analysis do not take direct account of the fact that
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67 the rate at which amino-acids are exchanged is different depending on the amino-acids.
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68 While this seems obvious (e.g. radical changes should happen slower), there are many technical reasons
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69 for why the standard assumption of "one-rate for all residues" holds.
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70
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71
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72 Given a set of N amino-acid properties, fit a site-level model where non-synonymous rates
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73 depend on how much a non-synonymous substitution changes the properties
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74 of the residue, beta (X,Y) = Exp (log_omega - lambda_1 * diff_1 (X,Y )-
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75 lambda_2 * diff_2 (X,Y) -...). When lambda_k > 0, changes in property k
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76 are disfavored and when lambda_k < 0 -- they are promoted. At each site,
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77 N+1 tests are performed (one for each property, and an omnibus test).
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78
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79 Input
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80 -----
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81
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82 1. A *FASTA* sequence alignment.
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83 2. A phylogenetic tree in the *Newick* format
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84
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85 Note: the names of sequences in the alignment must match the names of the sequences in the tree.
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86
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87
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88 Output
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89 ------
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90
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91 A JSON file with analysis results (http://hyphy.org/resources/json-fields.pdf).
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92
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93 A custom visualization module for viewing these results will soon be available at http://vision.hyphy.org/
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94
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95 Further reading
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96 ---------------
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97
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98 http://hyphy.org/methods/selection-methods/#PRIME
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99
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100
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101 Tool options
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102 ------------
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103 ::
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104
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105
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106 --code Which genetic code to use
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107
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108 --branches Which branches should be tested for selection?
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109 All [default] : test all branches
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110
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111 Internal : test only internal branches (suitable for
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112 intra-host pathogen evolution for example, where terminal branches
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113 may contain polymorphism data)
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114
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115 Leaves: test only terminal (leaf) branches
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116
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117 Unlabeled: if the Newick string is labeled using the {} notation,
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118 test only branches without explicit labels
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119 (see http://hyphy.org/tutorials/phylotree/)
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120
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121 --pvalue The significance level used to determine significance
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122
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123 --properties Which property set to use
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124 Atchley : Use the five properties derived from a factor analysis of 500 amino-acid properties [Table 2 in PNAS (2005) 102(18) 6395-6400 doi: 10.1073/pnas.0408677102]
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125 LCAP: Use the five properties defined in the Conant and Stadler LCAP model [Mol Biol Evol (2009) 26 (5): 1155-1161. doi: 10.1093/molbev/msp031]
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126
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127
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128 ]]></help>
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129 <expand macro="citations" />
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130 </tool>