Mercurial > repos > iuc > macs2
diff readme.rst @ 0:fe62ba547975 draft
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author | iuc |
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date | Wed, 11 Feb 2015 10:18:02 -0500 |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/readme.rst Wed Feb 11 10:18:02 2015 -0500 @@ -0,0 +1,60 @@ +======================== +Galaxy wrapper for MACS2 +======================== + +With the improvement of sequencing techniques, chromatin immunoprecipitation +followed by high throughput sequencing (ChIP-Seq) is getting popular to study +genome-wide protein-DNA interactions. To address the lack of powerful ChIP-Seq +analysis method, we present a novel algorithm, named Model-based Analysis of +ChIP-Seq (MACS), for identifying transcript factor binding sites. MACS captures +the influence of genome complexity to evaluate the significance of enriched ChIP +regions, and MACS improves the spatial resolution of binding sites through +combining the information of both sequencing tag position and orientation. +MACS can be easily used for ChIP-Seq data alone, or with control sample with the increase of specificity. + + +============ +Installation +============ + +It is recommended to install this wrapper via the `Galaxy Tool Shed`. + +.. _`Galaxy Tool Shed`: http://toolshed.g2.bx.psu.edu/view/modencode-dcc/macs2 + + +======= +History +======= +- v2.0.10.1: Initial public release +- v2.0.10.3: add "broad peaks" options + + +==================== +Detailed description +==================== + +View the original MACS2 documentation: https://github.com/taoliu/MACS/blob/master/README.rst + + +=============================== +Wrapper Licence (MIT/BSD style) +=============================== + +Permission to use, copy, modify, and distribute this software and its +documentation with or without modifications and for any purpose and +without fee is hereby granted, provided that any copyright notices +appear in all copies and that both those copyright notices and this +permission notice appear in supporting documentation, and that the +names of the contributors or copyright holders not be used in +advertising or publicity pertaining to distribution of the software +without specific prior permission. + +THE CONTRIBUTORS AND COPYRIGHT HOLDERS OF THIS SOFTWARE DISCLAIM ALL +WARRANTIES WITH REGARD TO THIS SOFTWARE, INCLUDING ALL IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS, IN NO EVENT SHALL THE +CONTRIBUTORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY SPECIAL, INDIRECT +OR CONSEQUENTIAL DAMAGES OR ANY DAMAGES WHATSOEVER RESULTING FROM LOSS +OF USE, DATA OR PROFITS, WHETHER IN AN ACTION OF CONTRACT, NEGLIGENCE +OR OTHER TORTIOUS ACTION, ARISING OUT OF OR IN CONNECTION WITH THE USE +OR PERFORMANCE OF THIS SOFTWARE. +