Mercurial > repos > iuc > mageck_test
diff test-data/out.mle.log.txt @ 2:81bbbddcf285 draft
planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/mageck commit 49e456dda49db1f52fc876f406a10273a408b1a2
| author | iuc |
|---|---|
| date | Wed, 04 Apr 2018 11:03:59 -0400 |
| parents | b8da4d41aa1d |
| children |
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--- a/test-data/out.mle.log.txt Sat Feb 17 10:41:53 2018 -0500 +++ b/test-data/out.mle.log.txt Wed Apr 04 11:03:59 2018 -0400 @@ -1,749 +1,57 @@ -INFO @ Mon, 12 Feb 2018 21:46:26: Parameters: /home/maria/miniconda3/envs/mulled-v1-b1e6893952d2d7e4d51a13d040adcd7bea052bfdc57a24d59056014db875e749/bin/mageck mle -k /tmp/tmpRFR3vr/files/000/dataset_1.dat -d /tmp/tmpRFR3vr/files/000/dataset_2.dat -n output --norm-method median --genes-varmodeling 1000 --permutation-round 10 --adjust-method fdr --threads 1 -INFO @ Mon, 12 Feb 2018 21:46:27: Cannot parse design matrix as a string; try to parse it as a file name ... -INFO @ Mon, 12 Feb 2018 21:46:27: Design matrix: -INFO @ Mon, 12 Feb 2018 21:46:27: [[1. 0. 0.] -INFO @ Mon, 12 Feb 2018 21:46:27: [1. 0. 0.] -INFO @ Mon, 12 Feb 2018 21:46:27: [1. 1. 0.] -INFO @ Mon, 12 Feb 2018 21:46:27: [1. 0. 1.]] -INFO @ Mon, 12 Feb 2018 21:46:27: Beta labels:baseline,HL60,KBM7 -INFO @ Mon, 12 Feb 2018 21:46:27: Included samples:HL60.initial,KBM7.initial,HL60.final,KBM7.final -INFO @ Mon, 12 Feb 2018 21:46:27: Loaded samples:HL60.initial;KBM7.initial;HL60.final;KBM7.final -INFO @ Mon, 12 Feb 2018 21:46:27: Sample index: 0;1;2;3 -INFO @ Mon, 12 Feb 2018 21:46:27: Loaded 100 genes. -DEBUG @ Mon, 12 Feb 2018 21:46:27: Initial (total) size factor: 1.6654412961322171 2.025116092944715 0.720025234995028 0.6592307725342162 -DEBUG @ Mon, 12 Feb 2018 21:46:27: Median factor: 1.4705915949061357 1.773663484525946 0.6311218804203026 0.5731039100868989 -INFO @ Mon, 12 Feb 2018 21:46:27: Final size factor: 1.4705915949061357 1.773663484525946 0.6311218804203026 0.5731039100868989 -INFO @ Mon, 12 Feb 2018 21:46:27: size factor: 0.6799984465189518,0.5638048078028025,1.5844800046134337,1.744884273862957 -INFO @ Mon, 12 Feb 2018 21:46:27: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:46:27: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:46:27: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:46:27: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:46:27: All threads completed. -INFO @ Mon, 12 Feb 2018 21:46:27: Modeling the mean and variance ... -INFO @ Mon, 12 Feb 2018 21:46:27: Linear regression: y=-0.902175602829449x+14.539230037913281 -INFO @ Mon, 12 Feb 2018 21:46:27: Run the algorithm for the second time ... -WARNING @ Mon, 12 Feb 2018 21:46:27: A1CF: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:27: A1CF: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:28: A1CF: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:28: A1CF: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:29: A1CF: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:29: A1CF: alpha: 0.09 -INFO @ Mon, 12 Feb 2018 21:46:29: Calculating AAAS (1) ... -WARNING @ Mon, 12 Feb 2018 21:46:29: AAAS: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:29: AAAS: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:30: AAAS: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:30: AAAS: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:31: AAAS: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:31: AAAS: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:31: AAK1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:31: AAK1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:31: AAK1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:31: AAK1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:32: AAK1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:32: AAK1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:32: AATF: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:32: AATF: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:33: AATF: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:33: AATF: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:33: AATF: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:33: AATF: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:33: AATK: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:33: AATK: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:34: AATK: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:34: AATK: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:35: AATK: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:35: AATK: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:35: ABCB8: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:35: ABCB8: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:36: ABCB8: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:36: ABCB8: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:37: ABCB8: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:37: ABCB8: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:37: ABCC1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:37: ABCC1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:38: ABCC1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:38: ABCC1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:38: ABCC1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:38: ABCC1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:38: ABCF1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:38: ABCF1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:39: ABCF1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:39: ABCF1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:40: ABCF1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:40: ABCF1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:40: ABHD14B: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:40: ABHD14B: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:41: ABHD14B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:41: ABHD14B: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:42: ABHD14B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:42: ABHD14B: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:42: ABI1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:42: ABI1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:43: ABI1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:43: ABI1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:44: ABI1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:44: ABI1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:44: ABL1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:44: ABL1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:44: ABL1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:44: ABL1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:45: ABL1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:45: ABL1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:45: ABL2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:45: ABL2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:46: ABL2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:46: ABL2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:47: ABL2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:47: ABL2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:47: ABLIM2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:47: ABLIM2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:48: ABLIM2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:48: ABLIM2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:49: ABLIM2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:49: ABLIM2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:49: ABT1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:49: ABT1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:50: ABT1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:50: ABT1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:50: ABTB1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:50: ABTB1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:51: ABTB1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:51: ABTB1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:52: ABTB1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:52: ABTB1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:52: ACAD11: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:52: ACAD11: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:53: ACAD11: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:53: ACAD11: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:54: ACAD11: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:54: ACAD11: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:54: ACAD9: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:54: ACAD9: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:55: ACAD9: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:55: ACAD9: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:55: ACAD9: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:55: ACAD9: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:56: ACAT2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:56: ACAT2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:56: ACAT2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:56: ACAT2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:57: ACAT2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:57: ACAT2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:57: ACBD6: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:57: ACBD6: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:46:58: ACBD6: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:58: ACBD6: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:46:59: ACBD6: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:46:59: ACBD6: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:46:59: ACD: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:46:59: ACD: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:00: ACD: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:00: ACD: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:00: ACD: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:00: ACD: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:00: ACHE: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:00: ACHE: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:01: ACHE: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:01: ACHE: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:02: ACHE: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:02: ACHE: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:02: ACIN1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:02: ACIN1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:03: ACIN1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:03: ACIN1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:04: ACIN1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:04: ACIN1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:04: ACLY: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:04: ACLY: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:05: ACLY: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:05: ACLY: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:05: ACO2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:05: ACO2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:06: ACO2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:06: ACO2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:07: ACO2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:07: ACO2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:07: ACP1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:07: ACP1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:08: ACP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:08: ACP1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:08: ACP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:08: ACP1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:08: ACRC: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:08: ACRC: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:09: ACRC: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:09: ACRC: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:10: ACRC: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:10: ACRC: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:10: ACSL6: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:10: ACSL6: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:11: ACSL6: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:11: ACSL6: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:11: ACSL6: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:11: ACSL6: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:11: ACSS2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:11: ACSS2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:12: ACSS2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:12: ACSS2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:13: ACSS2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:13: ACSS2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:13: ACTL6A: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:13: ACTL6A: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:13: ACTL6A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:13: ACTL6A: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:14: ACTL6A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:14: ACTL6A: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:14: ACTL6B: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:14: ACTL6B: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:15: ACTL6B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:15: ACTL6B: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:16: ACTL6B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:16: ACTL6B: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:16: ACTL7A: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:16: ACTL7A: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:16: ACTL7A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:16: ACTL7A: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:17: ACTL7A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:17: ACTL7A: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:17: ACTN1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:17: ACTN1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:18: ACTN1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:18: ACTN1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:19: ACTN1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:19: ACTN1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:19: ACTN4: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:19: ACTN4: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:19: ACTN4: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:19: ACTN4: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:20: ACTN4: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:20: ACTN4: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:20: ACTR1A: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:20: ACTR1A: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:21: ACTR1A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:21: ACTR1A: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:22: ACTR1A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:22: ACTR1A: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:22: ACTR3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:22: ACTR3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:22: ACTR3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:22: ACTR3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:23: ACTR3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:23: ACTR3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:23: ACTR5: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:23: ACTR5: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:24: ACTR5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:24: ACTR5: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:25: ACTR5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:25: ACTR5: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:25: ACTR8: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:25: ACTR8: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:25: ACTR8: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:25: ACTR8: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:26: ACTR8: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:26: ACTR8: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:26: ACTRT3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:26: ACTRT3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:27: ACTRT3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:27: ACTRT3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:28: ACTRT3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:28: ACTRT3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:28: ACVR1B: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:28: ACVR1B: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:28: ACVR1B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:28: ACVR1B: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:29: ACVR1B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:29: ACVR1B: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:29: ACVR1C: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:29: ACVR1C: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:30: ACVR1C: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:30: ACVR1C: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:30: ACVR1C: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:30: ACVR1C: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:30: ACVR1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:30: ACVR1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:31: ACVR1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:31: ACVR1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:32: ACVR1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:32: ACVR1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:32: ACVR2A: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:32: ACVR2A: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:33: ACVR2A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:33: ACVR2A: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:33: ACVR2A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:33: ACVR2A: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:33: ACVR2B: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:33: ACVR2B: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:34: ACVR2B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:34: ACVR2B: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:35: ACVR2B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:35: ACVR2B: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:35: ACVRL1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:35: ACVRL1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:36: ACVRL1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:36: ACVRL1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:36: ACVRL1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:36: ACVRL1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:36: ADAD1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:36: ADAD1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:37: ADAD1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:37: ADAD1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:38: ADAD1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:38: ADAD1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:38: ADAM10: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:38: ADAM10: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:38: ADAM10: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:38: ADAM10: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:39: ADAM10: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:39: ADAM10: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:39: ADAM12: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:39: ADAM12: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:40: ADAM12: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:40: ADAM12: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:41: ADAM12: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:41: ADAM12: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:41: ADAMTS5: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:41: ADAMTS5: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:41: ADAMTS5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:41: ADAMTS5: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:42: ADAMTS5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:42: ADAMTS5: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:42: ADAP1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:42: ADAP1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:43: ADAP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:43: ADAP1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:44: ADAP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:44: ADAP1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:44: ADARB1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:44: ADARB1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:44: ADARB1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:44: ADARB1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:45: ADARB1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:45: ADARB1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:45: ADARB2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:45: ADARB2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:46: ADARB2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:46: ADARB2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:47: ADARB2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:47: ADARB2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:47: ADAR: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:47: ADAR: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:48: ADAR: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:48: ADAR: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:48: ADAR: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:48: ADAR: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:48: ADCK1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:48: ADCK1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:49: ADCK1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:49: ADCK1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:50: ADCK1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:50: ADCK1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:50: ADCK2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:50: ADCK2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:51: ADCK2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:51: ADCK2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:51: ADCK2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:51: ADCK2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:51: ADCK3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:51: ADCK3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:52: ADCK3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:52: ADCK3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:53: ADCK3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:53: ADCK3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:53: ADCK4: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:53: ADCK4: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:54: ADCK4: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:54: ADCK4: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:54: ADCK4: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:54: ADCK4: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:54: ADCK5: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:54: ADCK5: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:55: ADCK5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:55: ADCK5: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:56: ADCK5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:56: ADCK5: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:56: ADCY1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:56: ADCY1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:57: ADCY1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:57: ADCY1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:57: ADCY1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:57: ADCY1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:57: ADD1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:57: ADD1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:47:58: ADD1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:58: ADD1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:47:59: ADD1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:47:59: ADD1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:47:59: ADD3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:47:59: ADD3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:00: ADD3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:00: ADD3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:00: ADD3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:00: ADD3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:00: ADH5: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:00: ADH5: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:01: ADH5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:01: ADH5: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:02: ADH5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:02: ADH5: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:02: ADH7: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:02: ADH7: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:03: ADH7: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:03: ADH7: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:04: ADH7: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:04: ADH7: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:04: ADI1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:04: ADI1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:04: ADI1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:04: ADI1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:05: ADI1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:05: ADI1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:06: ADIRF: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:06: ADIRF: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:06: ADIRF: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:06: ADIRF: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:07: ADIRF: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:07: ADIRF: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:07: ADK: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:07: ADK: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:08: ADK: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:08: ADK: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:08: ADK: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:08: ADK: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:09: ADNP2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:09: ADNP2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:09: ADNP2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:09: ADNP2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:10: ADNP2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:10: ADNP2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:10: ADNP: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:10: ADNP: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:11: ADNP: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:11: ADNP: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:12: ADNP: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:12: ADNP: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:12: ADPRHL2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:12: ADPRHL2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:12: ADPRHL2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:12: ADPRHL2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:13: ADPRHL2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:13: ADPRHL2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:13: ADRA1A: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:13: ADRA1A: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:14: ADRA1A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:14: ADRA1A: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:14: ADRA1A: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:14: ADRA1A: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:14: ADRA1B: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:14: ADRA1B: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:15: ADRA1B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:15: ADRA1B: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:16: ADRA1B: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:16: ADRA1B: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:16: ADRB1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:16: ADRB1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:17: ADRB1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:17: ADRB1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:18: ADRB1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:18: ADRB1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:18: ADRB2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:18: ADRB2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:19: ADRB2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:19: ADRB2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:20: ADRB2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:20: ADRB2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:20: ADRB3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:20: ADRB3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:21: ADRB3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:21: ADRB3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:21: ADRB3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:21: ADRB3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:21: ADRBK1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:21: ADRBK1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:22: ADRBK1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:22: ADRBK1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:23: ADRBK1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:23: ADRBK1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:23: ADRBK2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:23: ADRBK2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:24: ADRBK2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:24: ADRBK2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:25: ADRBK2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:25: ADRBK2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:25: ADRM1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:25: ADRM1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:26: ADRM1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:26: ADRM1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:26: ADRM1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:26: ADRM1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:27: AEBP1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:27: AEBP1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:27: AEBP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:27: AEBP1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:28: AEBP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:28: AEBP1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:28: AEBP2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:28: AEBP2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:29: AEBP2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:29: AEBP2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:30: AEBP2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:30: AEBP2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:30: AEN: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:30: AEN: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:31: AEN: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:31: AEN: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:31: AEN: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:31: AEN: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:31: AES: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:31: AES: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:32: AES: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:32: AES: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:33: AES: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:33: AES: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:33: AFAP1L2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:33: AFAP1L2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:34: AFAP1L2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:34: AFAP1L2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:34: AFAP1L2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:34: AFAP1L2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:34: AFF1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:34: AFF1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:35: AFF1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:35: AFF1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:36: AFF1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:36: AFF1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:36: AFF2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:36: AFF2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:37: AFF2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:37: AFF2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:37: AFF2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:37: AFF2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:37: AFF3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:37: AFF3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:38: AFF3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:38: AFF3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:39: AFF3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:39: AFF3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:39: AFF4: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:39: AFF4: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:40: AFF4: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:40: AFF4: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:40: AFF4: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:40: AFF4: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:40: AFMID: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:40: AFMID: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:41: AFMID: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:41: AFMID: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:42: AFMID: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:42: AFMID: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:42: AFTPH: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:42: AFTPH: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:43: AFTPH: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:43: AFTPH: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:43: AFTPH: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:43: AFTPH: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:43: AGAP2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:43: AGAP2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:44: AGAP2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:44: AGAP2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:45: AGAP2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:45: AGAP2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:45: AGAP3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:45: AGAP3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:45: AGAP3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:45: AGAP3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:46: AGAP3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:46: AGAP3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:46: AGBL5: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:46: AGBL5: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:47: AGBL5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:47: AGBL5: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:48: AGBL5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:48: AGBL5: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:48: AGFG1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:48: AGFG1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:48: AGFG1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:48: AGFG1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:49: AGFG1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:49: AGFG1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:50: AGL: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:50: AGL: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:51: AGL: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:51: AGL: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:51: AGPAT3: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:51: AGPAT3: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:52: AGPAT3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:52: AGPAT3: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:52: AGPAT3: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:52: AGPAT3: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:52: AGPAT5: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:52: AGPAT5: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:53: AGPAT5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:53: AGPAT5: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:54: AGPAT5: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:54: AGPAT5: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:54: AGTPBP1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:54: AGTPBP1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:55: AGTPBP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:55: AGTPBP1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:55: AGTPBP1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:55: AGTPBP1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:55: AHCTF1: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:55: AHCTF1: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:56: AHCTF1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:56: AHCTF1: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:57: AHCTF1: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:57: AHCTF1: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:57: AHCY: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:57: AHCY: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:58: AHCY: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:58: AHCY: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:48:58: AHCY: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:58: AHCY: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:48:58: AHNAK2: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:48:58: AHNAK2: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:48:59: AHNAK2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:48:59: AHNAK2: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:49:00: AHNAK2: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:49:00: AHNAK2: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:49:01: AHNAK: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:49:01: AHNAK: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:49:01: AHNAK: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:49:01: AHNAK: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:49:02: AHNAK: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:49:02: AHNAK: alpha: 0.09 -WARNING @ Mon, 12 Feb 2018 21:49:02: AHRR: beta value does not converge. Try to increase the value of alpha .. -WARNING @ Mon, 12 Feb 2018 21:49:02: AHRR: alpha: 0.01 -WARNING @ Mon, 12 Feb 2018 21:49:03: AHRR: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:49:03: AHRR: alpha: 0.03 -WARNING @ Mon, 12 Feb 2018 21:49:04: AHRR: reaches the maximum number of iterations. -WARNING @ Mon, 12 Feb 2018 21:49:04: AHRR: alpha: 0.09 -INFO @ Mon, 12 Feb 2018 21:49:04: Permuting groups of gene with 9 sgRNAs per gene. Group progress: 1/2 -INFO @ Mon, 12 Feb 2018 21:49:04: Start permuting 10 rounds ... -INFO @ Mon, 12 Feb 2018 21:49:04: Collecting 999 sgRNAs from 100 genes. -INFO @ Mon, 12 Feb 2018 21:49:04: Permuting round 0 ... -INFO @ Mon, 12 Feb 2018 21:49:04: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:04: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:04: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:04: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:04: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:04: Permuting round 1 ... -INFO @ Mon, 12 Feb 2018 21:49:05: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:05: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:05: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:05: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:05: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:05: Permuting round 2 ... -INFO @ Mon, 12 Feb 2018 21:49:05: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:05: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:05: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:06: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:06: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:06: Permuting round 3 ... -INFO @ Mon, 12 Feb 2018 21:49:06: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:06: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:06: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:07: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:07: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:07: Permuting round 4 ... -INFO @ Mon, 12 Feb 2018 21:49:07: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:07: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:07: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:08: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:08: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:08: Permuting round 5 ... -INFO @ Mon, 12 Feb 2018 21:49:08: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:08: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:08: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:09: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:09: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:09: Permuting round 6 ... -INFO @ Mon, 12 Feb 2018 21:49:09: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:09: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:09: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:09: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:09: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:10: Permuting round 7 ... -INFO @ Mon, 12 Feb 2018 21:49:10: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:10: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:10: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:10: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:10: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:10: Permuting round 8 ... -INFO @ Mon, 12 Feb 2018 21:49:10: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:10: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:10: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:11: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:11: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:11: Permuting round 9 ... -INFO @ Mon, 12 Feb 2018 21:49:11: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:11: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:11: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:12: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:12: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:12: Assigning p values... -INFO @ Mon, 12 Feb 2018 21:49:12: Permuting groups of gene with 10 sgRNAs per gene. Group progress: 2/2 -INFO @ Mon, 12 Feb 2018 21:49:12: Start permuting 10 rounds ... -INFO @ Mon, 12 Feb 2018 21:49:12: Collecting 999 sgRNAs from 100 genes. -INFO @ Mon, 12 Feb 2018 21:49:12: Permuting round 0 ... -INFO @ Mon, 12 Feb 2018 21:49:12: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:12: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:12: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:13: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:13: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:13: Permuting round 1 ... -INFO @ Mon, 12 Feb 2018 21:49:13: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:13: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:13: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:14: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:14: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:14: Permuting round 2 ... -INFO @ Mon, 12 Feb 2018 21:49:14: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:14: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:14: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:15: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:15: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:15: Permuting round 3 ... -INFO @ Mon, 12 Feb 2018 21:49:15: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:15: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:15: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:16: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:16: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:16: Permuting round 4 ... -INFO @ Mon, 12 Feb 2018 21:49:16: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:16: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:16: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:16: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:16: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:17: Permuting round 5 ... -INFO @ Mon, 12 Feb 2018 21:49:17: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:17: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:17: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:17: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:17: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:18: Permuting round 6 ... -INFO @ Mon, 12 Feb 2018 21:49:18: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:18: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:18: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:19: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:19: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:19: Permuting round 7 ... -INFO @ Mon, 12 Feb 2018 21:49:19: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:19: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:19: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:20: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:20: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:20: Permuting round 8 ... -INFO @ Mon, 12 Feb 2018 21:49:20: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:20: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:20: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:21: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:21: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:21: Permuting round 9 ... -INFO @ Mon, 12 Feb 2018 21:49:21: Thread 0 started. -INFO @ Mon, 12 Feb 2018 21:49:21: Thread 0: total 100 instances. -INFO @ Mon, 12 Feb 2018 21:49:21: Thread 0: Calculating AAAS (1) ... -INFO @ Mon, 12 Feb 2018 21:49:21: Thread 0 completed. -INFO @ Mon, 12 Feb 2018 21:49:21: All threads completed. -INFO @ Mon, 12 Feb 2018 21:49:22: Assigning p values... -INFO @ Mon, 12 Feb 2018 21:49:22: Writing gene results to output.gene_summary.txt -INFO @ Mon, 12 Feb 2018 21:49:22: Writing sgRNA results to output.sgrna_summary.txt +INFO @ Sun, 25 Mar 2018 22:27:41: Parameters: /Users/doylemaria/miniconda3/envs/mulled-v1-9ee130591ca78526e74a59d8d6dc03cb7db20645470975762936caeac62972dc/bin/mageck mle -k /private/var/folders/zn/m_qvr9zd7tq0wdtsbq255f8xypj_zg/T/tmpELNsjE/files/000/dataset_28.dat -d /private/var/folders/zn/m_qvr9zd7tq0wdtsbq255f8xypj_zg/T/tmpELNsjE/files/000/dataset_29.dat -n output --norm-method median --threads 1 +INFO @ Sun, 25 Mar 2018 22:27:42: Cannot parse design matrix as a string; try to parse it as a file name ... +INFO @ Sun, 25 Mar 2018 22:27:42: Design matrix: +INFO @ Sun, 25 Mar 2018 22:27:42: [[1. 0. 0.] +INFO @ Sun, 25 Mar 2018 22:27:42: [1. 0. 0.] +INFO @ Sun, 25 Mar 2018 22:27:42: [1. 1. 0.] +INFO @ Sun, 25 Mar 2018 22:27:42: [1. 0. 1.]] +INFO @ Sun, 25 Mar 2018 22:27:42: Beta labels:baseline,HL60,KBM7 +INFO @ Sun, 25 Mar 2018 22:27:42: Included samples:HL60.initial,KBM7.initial,HL60.final,KBM7.final +INFO @ Sun, 25 Mar 2018 22:27:42: Loaded samples:HL60.initial;KBM7.initial;HL60.final;KBM7.final +INFO @ Sun, 25 Mar 2018 22:27:42: Sample index: 0;1;2;3 +INFO @ Sun, 25 Mar 2018 22:27:42: Loaded 100 genes. +DEBUG @ Sun, 25 Mar 2018 22:27:42: Initial (total) size factor: 1.6654412961322171 2.025116092944715 0.720025234995028 0.6592307725342162 +DEBUG @ Sun, 25 Mar 2018 22:27:42: Median factor: 1.4705915949061357 1.773663484525946 0.6311218804203026 0.5731039100868989 +INFO @ Sun, 25 Mar 2018 22:27:42: Final size factor: 1.4705915949061357 1.773663484525946 0.6311218804203026 0.5731039100868989 +INFO @ Sun, 25 Mar 2018 22:27:42: size factor: 0.6799984465189518,0.5638048078028025,1.5844800046134337,1.744884273862957 +INFO @ Sun, 25 Mar 2018 22:27:42: Thread 0 started. +INFO @ Sun, 25 Mar 2018 22:27:42: Thread 0: total 1 instances. +INFO @ Sun, 25 Mar 2018 22:27:42: Thread 0 completed. +INFO @ Sun, 25 Mar 2018 22:27:42: All threads completed. +INFO @ Sun, 25 Mar 2018 22:27:42: Modeling the mean and variance ... +INFO @ Sun, 25 Mar 2018 22:27:42: Run the algorithm for the second time ... +INFO @ Sun, 25 Mar 2018 22:27:42: Calculating AAAS (1) ... +INFO @ Sun, 25 Mar 2018 22:27:43: Permuting groups of gene with 9 sgRNAs per gene. Group progress: 1/2 +INFO @ Sun, 25 Mar 2018 22:27:43: Start permuting 2 rounds ... +INFO @ Sun, 25 Mar 2018 22:27:43: Collecting 999 sgRNAs from 100 genes. +INFO @ Sun, 25 Mar 2018 22:27:43: Permuting round 0 ... +INFO @ Sun, 25 Mar 2018 22:27:43: Thread 0 started. +INFO @ Sun, 25 Mar 2018 22:27:43: Thread 0: total 100 instances. +INFO @ Sun, 25 Mar 2018 22:27:43: Thread 0: Calculating AAAS (1) ... +INFO @ Sun, 25 Mar 2018 22:27:45: Thread 0 completed. +INFO @ Sun, 25 Mar 2018 22:27:45: All threads completed. +INFO @ Sun, 25 Mar 2018 22:27:45: Permuting round 1 ... +INFO @ Sun, 25 Mar 2018 22:27:45: Thread 0 started. +INFO @ Sun, 25 Mar 2018 22:27:45: Thread 0: total 100 instances. +INFO @ Sun, 25 Mar 2018 22:27:45: Thread 0: Calculating AAAS (1) ... +INFO @ Sun, 25 Mar 2018 22:27:46: Thread 0 completed. +INFO @ Sun, 25 Mar 2018 22:27:46: All threads completed. +INFO @ Sun, 25 Mar 2018 22:27:46: Assigning p values... +INFO @ Sun, 25 Mar 2018 22:27:46: Permuting groups of gene with 10 sgRNAs per gene. Group progress: 2/2 +INFO @ Sun, 25 Mar 2018 22:27:46: Start permuting 2 rounds ... +INFO @ Sun, 25 Mar 2018 22:27:46: Collecting 999 sgRNAs from 100 genes. +INFO @ Sun, 25 Mar 2018 22:27:46: Permuting round 0 ... +INFO @ Sun, 25 Mar 2018 22:27:47: Thread 0 started. +INFO @ Sun, 25 Mar 2018 22:27:47: Thread 0: total 100 instances. +INFO @ Sun, 25 Mar 2018 22:27:47: Thread 0: Calculating AAAS (1) ... +INFO @ Sun, 25 Mar 2018 22:27:48: Thread 0 completed. +INFO @ Sun, 25 Mar 2018 22:27:48: All threads completed. +INFO @ Sun, 25 Mar 2018 22:27:49: Permuting round 1 ... +INFO @ Sun, 25 Mar 2018 22:27:49: Thread 0 started. +INFO @ Sun, 25 Mar 2018 22:27:49: Thread 0: total 100 instances. +INFO @ Sun, 25 Mar 2018 22:27:49: Thread 0: Calculating AAAS (1) ... +INFO @ Sun, 25 Mar 2018 22:27:50: Thread 0 completed. +INFO @ Sun, 25 Mar 2018 22:27:50: All threads completed. +INFO @ Sun, 25 Mar 2018 22:27:50: Assigning p values... +INFO @ Sun, 25 Mar 2018 22:27:50: Writing gene results to output.gene_summary.txt +INFO @ Sun, 25 Mar 2018 22:27:50: Writing sgRNA results to output.sgrna_summary.txt