@ref1_grp1_p001/1 1:N:0:AC+GT	MD:Z:10	RG:Z:grp1	BC:Z:AC-GT
CGAGCTCGGT
+
!!!!!!!!!!
@ref1_grp1_p002/1 1:N:0:AATT+CCGG	MD:Z:10	RG:Z:grp1	BC:Z:AATT+CCGG
CTCGGTACCC
+
##########
@ref1_grp1_p003/1 1:N:0:0	MD:Z:10	RG:Z:grp1
GTACCCGGGG
+
%%%%%%%%%%
@ref1_grp1_p004/1 1:N:0:0	MD:Z:10	RG:Z:grp1
CCGGGGATCC
+
''''''''''
@ref1_grp1_p005/1 1:N:0:0	MD:Z:10	RG:Z:grp1	ia:i:40000
GGATCCTCTA
+
))))))))))
@ref1_grp1_p006/1 1:N:0:0	MD:Z:10	RG:Z:grp1	ia:i:255
CCTCTAGAGT
+
++++++++++
@ref1_grp2_p001/1 1:N:0:TG+CA	MD:Z:8	RG:Z:grp2	BC:Z:TG+CA	QT:Z:ab+cd
AGCTCGGTAC
+
""""""""""
@ref1_grp2_p002/1 1:N:0:0	MD:Z:10	RG:Z:grp2
CGGTACCCGG
+
$$$$$$$$$$
@ref1_grp2_p003/1 1:N:0:0	MD:Z:10	RG:Z:grp2	ia:i:4294967295
ACCCGGGGAT
+
&&&&&&&&&&
@ref1_grp2_p004/1 1:N:0:0	MD:Z:10	RG:Z:grp2	ia:i:-2147483648
GGGGATCCTC
+
((((((((((
@ref1_grp2_p005/1 1:N:0:0	MD:Z:10	RG:Z:grp2	ia:i:-1000
ATCCTCTAGA
+
**********
@ref1_grp2_p006/1 1:N:0:0	MD:Z:10	RG:Z:grp2	ia:i:-1
TCTAGAGTCG
+
,,,,,,,,,,
@ref2_grp3_p001/1 1:N:0:0	MD:Z:15	RG:Z:grp3
GTGACACTATAGAAT
+
~~~~~~~~~~~~~~~
@ref2_grp3_p002/1 1:N:0:0	MD:Z:15	RG:Z:grp3
CTGTTTCCTGTGTGA
+
{{{{{{{{{{{{{{{
@ref2_grp3_p003/1 1:N:0:0	MD:Z:1T0T0C0T0A0T0A0G0T0G0T0C0A0C0	RG:Z:grp3
ACGTMRWSYKVHDBN
+
0123456789abcd!
@ref12_grp1_p001/1 1:N:0:0	MD:Z:10	RG:Z:grp1
TGCAGGCATG
+
AAAAAAAAAA
@ref12_grp2_p001/1 1:N:0:0	MD:Z:10	RG:Z:grp2
CAAGCTTGAG
+
AAAAAAAAAA