Mercurial > repos > matces > carpet_toolsuite
annotate carpet-src-1/tools/CARPET/com_uni.cpp @ 0:cdd489d98766
Migrated tool version 1.0.0 from old tool shed archive to new tool shed repository
| author | matces | 
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| date | Tue, 07 Jun 2011 16:50:41 -0400 | 
| parents | |
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| rev | line source | 
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1 /* | 
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2 * Copyright 2009 Matteo Cesaroni, Lucilla Luzi | 
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3 * | 
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4 * This program is free software; ; you can redistribute it and/or modify | 
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5 * it under the terms of the GNU Lesser General Public License as published by | 
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6 * the Free Software Foundation; either version 3 of the License, or (at your | 
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7 * option) any later version. | 
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8 * | 
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9 * This program is distributed in the hope that it will be useful, | 
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10 * but WITHOUT ANY WARRANTY; without even the implied warranty of | 
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11 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the | 
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12 * GNU General Public License for more details. | 
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13 | 
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14 */ | 
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15 | 
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16 #include <iostream> | 
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17 #include <fstream> | 
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18 #include <string> | 
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19 #include <vector> | 
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20 #include <algorithm> | 
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21 #include <sstream> | 
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22 #include <deque> | 
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23 #include <map> | 
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24 #include <ctime> | 
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25 #include <cstdlib> | 
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26 | 
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27 using namespace std; | 
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28 | 
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29 inline void Tokenize(const string& str, | 
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30 vector<string>& tokens, | 
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31 const string& delimiters = " ") | 
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32 { | 
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33 // Skip delimiters at beginning. | 
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34 string::size_type lastPos = str.find_first_not_of(delimiters, 0); | 
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35 // Find first "non-delimiter". | 
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36 string::size_type pos = str.find_first_of(delimiters, lastPos); | 
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37 | 
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38 while (string::npos != pos || string::npos != lastPos) | 
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39 { | 
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40 // Found a token, add it to the vector. | 
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41 tokens.push_back(str.substr(lastPos, pos - lastPos)); | 
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42 // Skip delimiters. Note the "not_of" | 
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43 lastPos = str.find_first_not_of(delimiters, pos); | 
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44 // Find next "non-delimiter" | 
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45 pos = str.find_first_of(delimiters, lastPos); | 
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46 } | 
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47 } | 
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48 | 
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49 | 
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50 typedef struct { | 
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51 int inizioprobe; | 
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52 int fineprobe; | 
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53 string score; | 
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54 string campo1; | 
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55 string campo2; | 
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56 string strand; | 
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57 string index; | 
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58 int file; | 
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59 } Probe; | 
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60 | 
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61 struct Comparatore2 { | 
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62 bool operator()(const Probe& s1, const Probe& s2) const { | 
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63 if (s1.inizioprobe < s2.inizioprobe) { | 
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64 return true; | 
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65 } | 
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66 else if (s1.inizioprobe == s2.inizioprobe) { | 
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67 if (s1.fineprobe < s2.fineprobe) { | 
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68 return true; | 
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69 } | 
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70 else if (s1.fineprobe == s2.fineprobe){ | 
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71 return true; | 
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72 } | 
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73 else { | 
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74 return false; | 
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75 } | 
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76 | 
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77 } | 
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78 else { | 
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79 return false; | 
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80 } | 
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81 | 
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82 } | 
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83 }; | 
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84 | 
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85 int main (int argc, char * const argv[]) { | 
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86 | 
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87 string concatenate=argv[3]; | 
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88 int dist_t=atoi(argv[1]); | 
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89 string choice=argv[2]; | 
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90 | 
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91 string name_out= argv[6]; | 
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92 ofstream resfile; | 
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93 resfile.open (name_out.c_str()); | 
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94 | 
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95 | 
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96 | 
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97 if (concatenate=="no" && choice!="union"){ | 
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98 | 
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99 //print "flank=$win , type=$type col6=%overlap, concatenate=$concatenate"; | 
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100 if (choice=="common"){ | 
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101 cout<<"flank="<<dist_t<<" , type="<<choice<<" , col6=%overlap, concatenate="<<concatenate; | 
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102 } | 
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103 if (choice=="unique"){ | 
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104 cout<<"flank="<<dist_t<<" , type="<<choice<<" , col6=score o p-value"; | 
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105 } | 
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106 | 
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107 string line; | 
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108 Probe thisprobe; | 
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109 Probe thisanno; | 
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110 int overlap=0; | 
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111 vector<string> arraypro; | 
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112 map<string, vector<Probe> > seq; | 
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113 map<string, vector<Probe> > annotation; | 
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114 map<string, vector<Probe> >::iterator itseq; | 
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115 | 
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116 ifstream seque_file(argv[4]); | 
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117 while (getline(seque_file, line)) { | 
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118 string s4; | 
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119 s4.assign(line, 0, 1); | 
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120 if (line=="" || s4=="#"){ | 
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121 continue; | 
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122 } | 
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123 arraypro.clear(); | 
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124 Tokenize(line, arraypro, "\t"); | 
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125 string chr2 = (arraypro[0].c_str()); | 
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126 thisprobe.inizioprobe=atoi(arraypro[3].c_str()); | 
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127 thisprobe.fineprobe=atoi(arraypro[4].c_str()); | 
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128 thisprobe.campo1=(arraypro[1].c_str()); | 
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129 thisprobe.campo2=(arraypro[2].c_str()); | 
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130 thisprobe.score=(arraypro[5].c_str()); | 
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131 thisprobe.strand=(arraypro[6].c_str()); | 
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132 thisprobe.index=(arraypro[8].c_str()); | 
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133 seq[chr2].push_back(thisprobe); | 
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134 } | 
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135 | 
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136 | 
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137 ifstream anno_file(argv[5]); | 
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138 while (getline(anno_file, line)) { | 
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139 string s4; | 
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140 s4.assign(line, 0, 1); | 
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141 if (line=="" || s4=="#"){ | 
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142 continue; | 
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143 } | 
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144 arraypro.clear(); | 
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145 Tokenize(line, arraypro, "\t"); | 
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146 string chr3= (arraypro[0].c_str()); | 
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147 thisanno.inizioprobe=atoi(arraypro[3].c_str()); | 
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148 thisanno.fineprobe=atoi(arraypro[4].c_str()); | 
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149 thisanno.campo1=(arraypro[1].c_str()); | 
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150 thisanno.campo2=(arraypro[2].c_str()); | 
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151 thisanno.score=(arraypro[5].c_str()); | 
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152 thisanno.strand=(arraypro[6].c_str()); | 
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153 thisanno.index=(arraypro[8].c_str()); | 
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154 annotation[chr3].push_back(thisanno); | 
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155 } | 
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156 | 
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157 | 
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158 for ( itseq=seq.begin() ; itseq != seq.end(); itseq++ ){ | 
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159 | 
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160 vector <Probe> seq_chr = (*itseq).second; | 
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161 vector <Probe> anno_chr = annotation[(*itseq).first]; | 
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162 if(anno_chr.size()==0 && choice=="unique"){ | 
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163 for (int i=0; i<seq_chr.size();i++){ | 
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164 resfile<<(*itseq).first<<"\t"<<seq_chr[i].campo1<<"\t"<<seq_chr[i].campo2<<"\t"<<seq_chr[i].inizioprobe<<"\t"<<seq_chr[i].fineprobe<<"\t"<<seq_chr[i].score<<"\t"<<seq_chr[i].strand<<"\t.\t"<<seq_chr[i].index<<endl; | 
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165 } | 
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166 continue; | 
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167 } | 
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168 if(anno_chr.size()==0 && choice=="common"){ | 
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169 continue; | 
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170 } | 
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171 sort (seq_chr.begin(),seq_chr.end(),Comparatore2()); | 
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172 sort (anno_chr.begin(),anno_chr.end(),Comparatore2()); | 
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173 | 
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174 int finefine=0; | 
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175 | 
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176 for (int i=0; i<anno_chr.size();i++){ | 
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177 if(anno_chr[i].fineprobe<=finefine){ | 
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178 anno_chr[i].fineprobe=finefine; | 
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179 } | 
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180 if(anno_chr[i].fineprobe>finefine){ | 
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181 finefine=anno_chr[i].fineprobe; | 
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182 } | 
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183 } | 
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184 | 
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185 for (int i=0; i<seq_chr.size();i++){ | 
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186 int start_array=0; | 
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187 int fine_array=anno_chr.size(); | 
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188 int pos=1; | 
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189 int trovato=0; | 
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190 | 
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191 while (pos>0){ | 
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192 pos=(fine_array-start_array)/2; | 
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193 int position=start_array+pos; | 
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194 | 
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195 if((seq_chr[i].inizioprobe-dist_t)<anno_chr[position].inizioprobe){ | 
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196 fine_array=position; | 
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197 } | 
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198 if((seq_chr[i].inizioprobe-dist_t)>anno_chr[position].inizioprobe){ | 
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199 start_array=position; | 
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200 } | 
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201 if((seq_chr[i].inizioprobe-dist_t)<=anno_chr[position].fineprobe && (seq_chr[i].fineprobe+dist_t)>=anno_chr[position].inizioprobe){ | 
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202 if (choice=="common"){ | 
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203 if (seq_chr[i].inizioprobe<=anno_chr[position].inizioprobe && seq_chr[i].fineprobe<=anno_chr[position].fineprobe){ | 
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204 overlap=(seq_chr[i].fineprobe-anno_chr[position].inizioprobe)*100/(seq_chr[i].fineprobe-seq_chr[i].inizioprobe); | 
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205 } | 
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206 if (seq_chr[i].inizioprobe<=anno_chr[position].inizioprobe && seq_chr[i].fineprobe>=anno_chr[position].fineprobe){ | 
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207 overlap=(anno_chr[position].fineprobe-anno_chr[position].inizioprobe)*100/(seq_chr[i].fineprobe-seq_chr[i].inizioprobe); | 
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208 } | 
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209 if (seq_chr[i].inizioprobe>=anno_chr[position].inizioprobe && seq_chr[i].fineprobe>=anno_chr[position].fineprobe){ | 
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210 overlap=(anno_chr[position].fineprobe-seq_chr[i].inizioprobe)*100/(seq_chr[i].fineprobe-seq_chr[i].inizioprobe); | 
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211 } | 
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212 if (seq_chr[i].inizioprobe>=anno_chr[position].inizioprobe && seq_chr[i].fineprobe<=anno_chr[position].fineprobe){ | 
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213 overlap=100; | 
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214 } | 
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215 if (overlap<0){ | 
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216 overlap=-1; | 
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217 } | 
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218 resfile<<(*itseq).first<<"\t"<<seq_chr[i].campo1<<"\t"<<seq_chr[i].campo2<<"\t"<<seq_chr[i].inizioprobe<<"\t"<<seq_chr[i].fineprobe<<"\t"<<overlap<<"\t"<<seq_chr[i].strand<<"\t.\t"<<"ValueA:"<<seq_chr[i].score<<"~"<<"ValueB:"<<anno_chr[position].score<<endl; | 
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219 } | 
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220 trovato=1; | 
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221 break; | 
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222 } | 
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223 } | 
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224 if (choice=="unique" && trovato==0){ | 
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225 resfile<<(*itseq).first<<"\t"<<seq_chr[i].campo1<<"\t"<<seq_chr[i].campo2<<"\t"<<seq_chr[i].inizioprobe<<"\t"<<seq_chr[i].fineprobe<<"\t"<<seq_chr[i].score<<"\t"<<seq_chr[i].strand<<"\t.\t"<<seq_chr[i].index<<endl; | 
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226 } | 
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227 } | 
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228 } | 
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229 } | 
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230 | 
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231 if (concatenate=="yes" || choice == "union"){ | 
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232 | 
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233 cout<<"flank="<<dist_t<<" , type="<<choice<<" , col6=#overlaping regions, concatenate="<<concatenate; | 
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234 | 
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235 string line; | 
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236 Probe thisprobe; | 
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237 Probe thisanno; | 
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238 vector<string> arraypro; | 
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239 map<string, vector<Probe> > seq; | 
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240 map<string, vector<Probe> > annotation; | 
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241 map<string, vector<Probe> >::iterator itseq; | 
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242 string concatenate=argv[3]; | 
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243 int dist_t=atoi(argv[1]); | 
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244 string choice=argv[2]; | 
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245 | 
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246 ifstream seque_file(argv[4]); | 
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247 while (getline(seque_file, line)) { | 
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248 string s4; | 
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249 s4.assign(line, 0, 1); | 
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250 if (line=="" || s4=="#"){ | 
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251 continue; | 
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252 } | 
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253 arraypro.clear(); | 
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254 Tokenize(line, arraypro, "\t"); | 
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255 string chr2 = (arraypro[0].c_str()); | 
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256 thisprobe.inizioprobe=atoi(arraypro[3].c_str()); | 
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257 thisprobe.fineprobe=atoi(arraypro[4].c_str()); | 
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258 thisprobe.campo2=(arraypro[2].c_str()); | 
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259 thisprobe.campo1=(arraypro[1].c_str()); | 
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260 thisprobe.score=(arraypro[5].c_str()); | 
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261 thisprobe.index=(arraypro[8].c_str()); | 
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262 thisprobe.strand=(arraypro[6].c_str()); | 
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263 thisprobe.file=1; | 
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264 seq[chr2].push_back(thisprobe); | 
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265 } | 
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266 | 
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267 ifstream anno_file(argv[5]); | 
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268 while (getline(anno_file, line)) { | 
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269 string s4; | 
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270 s4.assign(line, 0, 1); | 
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271 if (line=="" || s4=="#"){ | 
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272 continue; | 
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273 } | 
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274 arraypro.clear(); | 
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275 Tokenize(line, arraypro, "\t"); | 
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276 string chr3= (arraypro[0].c_str()); | 
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277 thisanno.inizioprobe=atoi(arraypro[3].c_str()); | 
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278 thisanno.fineprobe=atoi(arraypro[4].c_str()); | 
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279 thisanno.campo2=(arraypro[2].c_str()); | 
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280 thisanno.campo1=(arraypro[1].c_str()); | 
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281 thisanno.score=(arraypro[5].c_str()); | 
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282 thisanno.index=(arraypro[8].c_str()); | 
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283 thisanno.strand=(arraypro[6].c_str()); | 
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284 thisanno.file=2; | 
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285 seq[chr3].push_back(thisanno); | 
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286 } | 
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287 | 
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288 int inizio; | 
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289 int fine; | 
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290 string annot; | 
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291 int overlap; | 
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292 int inizio_ann; | 
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293 int fine_ann; | 
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294 | 
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295 for ( itseq=seq.begin() ; itseq != seq.end(); itseq++ ){ | 
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296 | 
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297 vector <Probe> seq_chr = (*itseq).second; | 
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298 sort (seq_chr.begin(),seq_chr.end(),Comparatore2()); | 
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299 | 
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300 for (int i=0; i<seq_chr.size();i++){ | 
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301 inizio = seq_chr[i].inizioprobe; | 
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302 fine=seq_chr[i].fineprobe; | 
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303 int file_t=0; | 
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304 int file_t2=0; | 
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305 int entrato=1; | 
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306 int z=1; | 
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307 if(seq_chr[i].file==1){ | 
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308 file_t=1; | 
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309 } | 
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310 if(seq_chr[i].file==2){ | 
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311 file_t2=1; | 
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312 } | 
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313 if(i==(seq_chr.size()-1)){ | 
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314 if (choice=="union"){ | 
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315 resfile<<(*itseq).first<<"\tfile_"<<seq_chr[i].file<<"\tunique\t"<<seq_chr[i].inizioprobe<<"\t"<<seq_chr[i].fineprobe<<"\t"<<seq_chr[i].score<<"\t"<<seq_chr[i].strand<<"\t.\t"<<seq_chr[i].index<<endl; | 
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316 } | 
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317 } | 
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318 | 
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319 //cout<<"x"<<(*itseq).first<<"\t"<<seq_chr[i].inizioprobe<<"\t"<<seq_chr[i].fineprobe<<"\t"<<seq_chr[i].file<<endl; | 
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320 for (int y=i+1; y<seq_chr.size(); y++){ | 
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321 if((inizio-dist_t)<=seq_chr[y].fineprobe && (fine+dist_t)>=seq_chr[y].inizioprobe){ | 
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322 if(seq_chr[y].file==1){ | 
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323 file_t=1; | 
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324 } | 
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325 if(seq_chr[y].file==2){ | 
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326 file_t2=1; | 
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327 } | 
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328 if(seq_chr[y].fineprobe>fine){ | 
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329 fine=seq_chr[y].fineprobe; | 
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330 } | 
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331 entrato=2; | 
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332 i++; | 
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333 z++; | 
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334 } | 
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335 if(seq_chr[y].inizioprobe>fine || y==seq_chr.size()-1){ | 
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336 if (choice == "union" && entrato==1){ | 
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337 resfile<<(*itseq).first<<"\tfile_"<<seq_chr[i].file<<"\tunique\t"<<inizio<<"\t"<<fine<<"\t"<<seq_chr[i].score<<"\t"<<seq_chr[i].strand<<"\t.\t"<<seq_chr[i].index<<endl; | 
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338 } | 
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339 if (choice == "union" && entrato==2){ | 
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340 resfile<<(*itseq).first<<"\tcommon\tcommon\t"<<inizio<<"\t"<<fine<<"\t"<<z<<"\t.\t.\tcommon"<<endl; | 
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341 } | 
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342 if (choice == "common" && entrato==2 && file_t == 1 && file_t2 == 1 && concatenate=="yes"){ | 
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343 resfile<<(*itseq).first<<"\t"<<seq_chr[i].campo1<<"\t"<<seq_chr[i].campo2<<"\t"<<inizio<<"\t"<<fine<<"\t"<<z<<"\t"<<seq_chr[i].strand<<"\t.\t"<<seq_chr[i].index<<endl; | 
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344 } | 
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345 break; | 
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346 } | 
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347 } | 
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348 } | 
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349 } | 
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350 } | 
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351 } | 
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352 | 
