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annotate discover_familial_relationships.py @ 39:e56023008e36 default tip

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Changed revision of package_fisher_0_1_4 to be2fc454d121 Changed revision of package_matplotlib_1_2 to a03ee94316b5
author miller-lab
date Mon, 06 Jul 2015 10:32:24 -0400
parents a631c2f6d913
children
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31
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1 #!/usr/bin/env python
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2
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3 import sys
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4 import gd_util
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5
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6 from Population import Population
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7
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8 ################################################################################
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9
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10 if len(sys.argv) != 6:
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11 gd_util.die('Usage')
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12
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13 input, input_type, ind_arg, pop_input, output = sys.argv[1:]
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14
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15 p_total = Population()
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16 p_total.from_wrapped_dict(ind_arg)
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17
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18 p1 = Population()
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19 p1.from_population_file(pop_input)
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20 if not p_total.is_superset(p1):
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21 gd_util.die('There is an individual in the population that is not in the SNP table')
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22
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23 ################################################################################
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24
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25 prog = 'kinship_prep'
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26
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27 args = [ prog ]
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28 args.append(input) # a Galaxy SNP table
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29 args.append(0) # required number of reads for each individual to use a SNP
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30 args.append(0) # required genotype quality for each individual to use a SNP
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31 args.append(0) # minimum spacing between SNPs on the same scaffold
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32
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33 for tag in p1.tag_list():
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34 if input_type == 'gd_genotype':
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35 column, name = tag.split(':')
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36 tag = '{0}:{1}'.format(int(column) - 2, name)
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37 args.append(tag)
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38
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39 gd_util.run_program(prog, args)
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40
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41 # kinship.map
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42 # kinship.ped
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43 # kinship.dat
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44
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45 ################################################################################
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46
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47 prog = 'king'
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48
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49 args = [ prog ]
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50 args.append('-d')
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51 args.append('kinship.dat')
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52 args.append('-p')
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53 args.append('kinship.ped')
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54 args.append('-m')
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55 args.append('kinship.map')
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56 args.append('--kinship')
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57
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58 gd_util.run_program(prog, args)
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59
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60 # king.kin
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61
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62 ################################################################################
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63
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64 valid_header = 'FID\tID1\tID2\tN_SNP\tZ0\tPhi\tHetHet\tIBS0\tKinship\tError\n'
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65
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66 with open('king.kin') as fh:
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67 header = fh.readline()
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68 if header != valid_header:
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69 gd_util.die('crap')
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70
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71 with open(output, 'w') as ofh:
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72
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73 for line in fh:
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74 elems = line.split('\t')
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75 if len(elems) != 10:
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76 gd_util.die('crap')
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77
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78 x = elems[1]
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79 y = elems[2]
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80 z = elems[8]
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81
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82 f = float(z)
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83
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84 message = ''
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85
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86 if f > 0.354:
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87 message = 'duplicate or MZ twin'
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88 elif f >= 0.177:
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89 message = '1st degree relatives'
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90 elif f >= 0.0884:
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91 message = '2nd degree relatives'
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92 elif f >= 0.0442:
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93 message = '3rd degree relatives'
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94
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95 print >> ofh, '\t'.join([x, y, z, message])
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96
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97 ################################################################################
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98
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99 sys.exit(0)
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100