Mercurial > repos > miller-lab > genome_diversity
view evaluate_population_numbers.xml @ 0:2c498d40ecde
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author | miller-lab |
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date | Mon, 09 Apr 2012 12:03:06 -0400 |
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<tool id="gd_evaluate_population_numbers" name="Evaluate" version="1.0.0"> <description>possible numbers of populations</description> <command interpreter="bash"> evaluate_population_numbers.bash "${input.extra_files_path}/admix.ped" "$output" "$max_populations" </command> <inputs> <param name="input" type="data" format="wped" label="Dataset" /> <param name="max_populations" type="integer" min="1" value="5" label="Maximum number of populations" /> </inputs> <outputs> <data name="output" format="txt" /> </outputs> <!-- <tests> <test> <param name="input" value="fake" ftype="wped" > <metadata name="base_name" value="admix" /> <composite_data value="test_out/prepare_population_structure/prepare_population_structure.html" /> <composite_data value="test_out/prepare_population_structure/admix.ped" /> <composite_data value="test_out/prepare_population_structure/admix.map" /> <edit_attributes type="name" value="fake" /> </param> <param name="max_populations" value="2" /> <output name="output" file="test_out/evaluate_population_numbers/evaluate_population_numbers.txt" /> </test> </tests> --> <help> **What it does** The users selects a set of data generated by the Galaxy tool to "prepare to look for population structure". For all possible numbers K of ancestral populations, from 1 up to a user-specified maximum, this tool produces values that indicate how well the data can be explained as genotypes from individuals derived from K ancestral populations. These values are computed by a 5-fold cross-validation procedure, so that a good choice for K will exhibit a low cross-validation error compared with other potential settings for K. **Acknowledgments** We use the program "Admixture", downloaded from http://www.genetics.ucla.edu/software/admixture/ and described in the paper "Fast model-based estimation of ancestry in unrelated individuals" by David H. Alexander, John Novembre and Kenneth Lange, Genome Research 19 (2009), pp. 1655-1664. Admixture is called with the "--cv" flag to produce these values. </help> </tool>