Mercurial > repos > peterjc > mira4_assembler
view test-data/U13small_m.fastq @ 1:70248e6e3efc draft
v0.0.7 move dependency to package_mira_4_0_2 etc
author | peterjc |
---|---|
date | Wed, 05 Aug 2015 11:31:05 -0400 |
parents | 6a88b42ce6b9 |
children |
line wrap: on
line source
@122533a.t3 ACGCGTTATTAAAGACTTTTTTTTTGGTTTTTTTCAAGTTCAAGTATTCTTTATTCAAAGTTGAAACATGTACCATACTGCATTATTGCAAAAATTCACTGGTACAAAACACTTTGCAGCTGGTGAGAAGGCAATAAAAAGTTGATTTTTAAACTCATTACTATAAATTATTCTTACAGTACTTTGCAAATTCAGAATTTCAAACTGCATGTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAGCTAAGGCAGCTGTTTCATAGGAGGGGGAAGAAGTATCAAATCTCTTGGGATTTCCATTTCTCTTTCCATGCCGACATACTTCAGGGCATCTTCCTGACTGTCTCTTTTTTCGGGAAACTTCTCTTCGCCAATCTGGATGGCTCTCTCGGCAAAAATACCTATCCTGTGATCACCGTTAACCATCATAACTTTTGCATACCACTTTGGATTTACCACCGATATGCCACAACGATTTTTGTTACCCTTGCAGGTTGCACCACCCAAAATCGTTGTTCTTTTGCCCTTGCCAAATTCTGGGCCCCAAGGGCCAATTCCCCAAAATTAATCCTTTTAATTTCGTGGGCCGCGTTCCAGCTGTCCCCCTTGTTGAAGGTTTTTTTTCGCCCCCCGGCTCTCCCCCCCCCTTTTTAAACCCCGTAAACCATTATAGTTGGTTAAACCCCCGGGGGGTTCCCCCTTGTAAATTTTACCCCCCCCTCTCCCCCATTTAAAAATATGTGCCCTTTTTCTCCCCCCCACTGGGCCCGGGGTTTTCTCCTATTCCGGGGAAAGAAAAACCCTGTTTTCTCTTCGCCAAAATACTCCCCCCCCCCTTTTTATAAAAAAAAAAAAAACTTGGGGGCCCCCACCCCCCCCCGGGGGGGAAAAAAAAAAGCGCGGGGTTTTTGCGCGTTTTTTTTGGGGGGGGGGGGGTTTCTTTTCCCCCCCTTTTTTCCTTCCCCCCCAAAGGAGAAAAAATCTTTTTTGTTGGGGCGCCTCCCGGCGCCCCTCCCGGGGTTGGCGCGGCGAAAACGCGGTTTTTCCCCCCCCCCCAAAGGGGGGGGCGCAGATACCGCGTTTACTCCCCATAAATACTCCGGGGGGGAATAACATCCCGGGAAAAAAAAATTTTATATCTATATATGGGGCCTCCCAAAAAGGGGCATAAAACACGGAGAAACCGGCGCCCTTGTGTGGGCGTTTTTCTCTCAATGGGCGCCCCCCCCCTCAACAAAAATAAAAA + '%+2*(6.+;8:2)+(*).1AA88(-,(88AA=;==99@;BC21-,,-8?91695?=5:7?;11,)(*-55==@:BABBAEABABA?BA??;<?<7AAAA?A<<B=9:620576:;@;4>>;@;;7*0/*22;@BCCBE@F?<??DACAAABDAACD?=<B?BB@DA@?B@<@=9B>@??8??678>0,6?9@>8>;?CAEAD??>@DEA>?4>A?C?8;7:A?ACCAADB>=-5;3>:/6-3:6@A4597->58:6318=B?DAA?72*/+.1)01771-.1.+/+).(610)-7-(,0-8968?:/A/4928,))-+1))21/1-6??>9:3-572629.)2510-+,,/5,3,*+.)*.)*+/.7>-..00,+.40:82+68.;2/,-.)+.-+*)**)626;?988623-37./5/1))78@>G<??>;5:>7:/--68;8?A40/,.1--.5:768.4))(())(+%)))+*))**((+(*(*0*--/;::2,+()))++)**,--:2**2/2(*)+,*))+((0-,/*))*+)*+-2+()++/**,,*-=751,,)((*25;(,,2),(-.(*,-+1-.,,./-%.%*1,,'()+)+('%.*)*))0,&(+(),),+++,/*./*,*,))))*)(%%%+-%**,3.+)0**202%-0,,20*/(*,*++))(0())()'(+))17:84.)+1.)))+))41,)$'''))'*0))&),3-,))++-)*+..*',,),+.+.((.**+++),*+,)%(.,/51+()''),.,*/--+(002/((,&+&*,*,+,,,*)*),*)-))*+*%.***,(+))$'&+%)*-'%*0.*+***///+.,,*)*),-*267<;30-(%)**(,1456;63)*,*,+=759.3-.342-*-+0())'))**,)200,)025))++++(*/466,',$))12*&///,)()*)/)+-),2-,**,*1.1.,***,)/,22-*%)),*&/)+',,++)/,**)((()))*,%(*)+)))(*&)).03&1;5:22))+))'.-))+&+/+)))((+*+,33=36-,,3//,+)+)),./+,)*+))*(*)))))%)),)$'+)+,*&)+++,-))**++7702&**1+)-*(*-+)+*)))/1.0.+,-)*)(**.*)**')'')$*.-)42)**00),+*)))%*,)).+.-.****(()(+)-)(()*.())((-*,(++//+,1*.-()/31/8/,/47;7,+(),324)*))(**0C@ @122533a.t7 GTTCGAGCAATATCCCTACGATCAACTAGAACAATGATTTTGTGGTGGATGCAACCCGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAACGGTGATCACAGGATAGGTATTTTTGCCAAGAGAGCCATCCAGACTGGCGAAGAGCTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTCGGCATCGAAAGAGAAATGGAAATCCCTTGACATCTGCTACCTCCTCCCCCTCCTCTGAAACAGCTGCCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAGAACATGCAGTTTGAAATTCTGAATTTGCAAAGTACTGTAAGAATAATTTATAGTAATGAGTTAAAAATCAACTTTTATTGCCTTCCACCACTGCAAGTGTTTGTACCGTGAATTTTGCAATAATGCCATATGGTACATTTTCCACTTTGAATAAAGAATACTTGAGCTTGAAAAAAAAAAAAAAAAAAGATTCTTTATTTAAGCGGCCGCGAGCTTTTCCCTTTAATAGGGTTAATTTAACTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX + &&&,1/?/,/(+)+'('+)(1.+*+,0**1-1574=====EBAABA=:=56;6879=>7-025<???@BA>>>;?ACBA?A?AAAEBEA?ABAA=FF@@??AA?@AA?A=@=A<<ACAAAD?==>@==@=@E=@@A@=A@;2:22-&623@DFBAABB=59;/888B?B?<72;;:@==84.)1,9AAEEFECB???;B?<>??;BCBAAAAAA?==>=@DA??;7.<8<524/37AA??><.,1.87====AEB@AAA===869BA@?=@=?AAAABBABBABAAAAAC==A??ABBBEEDAEEBA97:053064:A7;)2,,2.63:5==>=@:::A@;A=7A==A?AAA?A=9====??=D====B@@=:E=A@AAA?;4:6=64==?AABAB05**33/,116>E@==9=:=:?@=:A=466,-)*..--/1230627:3666;.,*(1,996E<6;5@=8=@8-(/))..033AAA:992/2/>674;65936400,-.62++,$**-8;34.**)118''4.**)+)))).11,**..-(.()+*))+$)$+')12,02*,.-,+*(,6*)*)1)(..8'!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! @122533b.t3 ACGCGTTATTAAAGATTTTTTTTTTGGTTTTTTTCAAGTTCAAGTATTCTTTATTCAAAGTTGAAAAATGTACCATACTGCATTATTGCAAAAATTCACTGGTACAAAACACTTTGCAGCTGGTGAGAAGGCAATAAAAAGTTGATTTTTAAACTCATTACTATAAATTATTCTTACAGTACTTTGCGTATTCAGAATTTCAAACTGCATGTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAACCTAAGGCAGCTGTTTCAGAGGAGGGGGAGAAAGTATCAAATCTCTAGGGATTTCCATTTCTCTTTCCACGCCGAAATACTTCACGGCATCTTCCTGACTGTCTCTTTATTCGGGCAACATCTCTTCACCACTCTGGATGGCTCTCTCGGCATAAATACCTTTCCGGTGATCTCCGTTAAACTTCTTAATTTTTTGGCATCCCCGTTTGGGATGTACCGCACTGAATTGCAAAAACTAATTTTTGTTTACCCCTTGACGGGTTGCCATCCCACCCCAAAAATCCTTTGTTTCAAATTTGCCTCCGTGACCAAAATAACCTTGGGCCCCCCTAATGGGCCAAATTTCCCCTCATTAGTTTGAATTTCCTTTTTAAATTTTCCCTTGGTCCGCGTTTCCTAAACTCCCTCCCCCCGGTGTTGAGGGTTTGGTTTTTCCCGCCTCGGCAAATTCCCCCCCCTCACTTTTTAAAAACCCCTGTAAACCCACTTGGGTTTTTAAACCCCCTGGGGGGTGTCCCAAAATTTAAAGTTTAACCCAATCCCCACACATTAACTTCCCTTTTCCCCCCCCCTGGCCCGTTTTCTCCTTTCGGGAGAAACCCGTTCTGTTCCCCCCCTCCCTTAAAAAAAATTCCCCCCACCCCCCAGGGAAAAAGCGGTTATATCCTCCTTGGGGCCTCTCCCCCTCTCCCCCCCCCGAGTATATCTTTGGTGTCCCCGGCGCCTTTTTGCCCGGAAAATGTGTTATGCCCCTATAAAGGGGGGTCTATGGGGTTTCCCCCACACCCGGGTTCCCCCGTAATAAACCTTTTTCTCCCCGGCCCCCAGGGCGGAAGCCCCAAGGGGGGTTTCTCATGTTTTTTCATGGGCCCCCCCCCAAAAAATAAAAATTAG + &%,0*)2*)209.+)'.+=A?@68),,(<<AA??@=<;?>CD7456<:?A3.31/8=05.51880+*+-31====AAAAAA???B@>@A;9:9;@;@@????::?D9:520/52:A??;>><?==A9940.58>AA@BECC@>@C@BAACDAA@@@@:>97??A@BBC?=13*(*-3,7764.,.6<,.?;?22)2/4?ACAA?@@@@@:;9-;;<C?2=<?DA@A@=BAA<7*033;5,7,.36CC;-5/*1.0.*./:=??:?D26,(2+0.).02..%'64.+(,))91/(-,(1(-10-.+11..-;924++,<1:*)-2*0-9.42./0*';:7><<*'981=53./2))*3,,.)(()*,+.2.0218.)05%3'))(**/31/**(+/)28.,.)6&,,++)*+(/+0*)*2-0)(&,0,,/25*,*30/*,*.5C;;,),*)+**,(%*)0,*.))''*+4)/*),,.-+)*+*+5:=8*.+,3.1.)*.*),,-1)(+**(.**-**(*(,*)**+-1,%%(****)((+(+..*+*(..,--*+(/%)*++*88231.,,*/+,,*+**,,))))..))509-,21:@50))*$(*&-,(,,,(**)(*+.**'***005711%%*(%+*$+))/+4.2)((+*)))))),35()())))*0()+*-)-)*,+,.*.1,++)()*&)7/.+*..9;)(('))**/4/1%+369160)*+*+.2&,**(*&**)+**,*,*2**021&*263+*+*()+***.-'))))))*+++,*;6+)**)+))+'()*/,-)*)*,-6.,*(-,;A77+++,,***+11030,,*((())((..+***+))*)*)***6:79-+)))),*)*-.510,.)*,+/0,,,,31,,*)+*,8:60+0(****1*(&)*.((+(*+*)+-+,).++/+,&*,3:99..,+++**)*-+)(&)*,*1*+*))))'-+)/+**&)()%,-,133**)(*(+%%.)**,)%+*(***0++()()+()+).+))*+)**)))))57*-))/51(*)**,*)))(*/2,++*-1('**/+.-***,*))),))**),%,),5*+,*-/+)()))*7:5+(*(*+*+278DA851)))()*,.,++**)))) @122533b.t7 CCGAGCAATATCCCCACGATCACTAGAAAATGATTTTGTGGTGGATGCAACCCGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAACGGTGATCACAGGATATGTATTTTTGCCAAGAGAGCCATCCAGACTGGCGAAGAGCTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTCGGCATCGAAAGAGAAATGGAAATCCCTTGACATCTGCTACCTCCTCCCCCTCCTCTGAAACAGCTGCCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAGAACATGCAGTTTGAAATTCTGAATTTGCAAAGTACTGTAAGAATAATTTATAGTAATGAGTTTAAAAATCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCAATAATGCAGTATGGTACATTTTCAACTTTGAGATAAAGAATACTTGAGCTTGAAAACAAAAATGTATCTTTATTAAAGCGGCGCAACCTATATCCCTTTTAAGTGAGGGGTTAATTTTAACTTTGGGCCCTGGCCCTCCTTTTTTACCAACCTTCTTTGAACTGGGGAAAAACACCTGGGCTTTTACCCAACCTTTATATCCGCCTTTGGGCAAACAAAATTCCCCCTTTTTTCCGCCAAAGCGGGGGGTTTTTTTTTTACCCAAAAAAAAAGGGCCCGCCCACCCCCTATATTTGCCGCCCCTCTCCTCCCCAAAACAATTTTTCCGCCCCCCCCCCCTTTAAAATTTTTGGGCGCCAAAAAATGTGGGGGGGAAACCCCCCCCCCCCCCTTTTTTTTCCCCCGGCGCGCCCCATATTTTTAAAAACCCCCCCCCCCCGGGGGGTGGTTTTTTTTGTTGGGGGTTTTCCCCCCCCCCCCCCCCCCCACCCTTTTTTTTAAAAACCCCCCTCTATTTTAAAACATCTTTTTGTTGGCCCAAAGACCCCCCCCCCCCCTATTAATAAACCCCCCCCCCCCCCCCCCCCCTTTTTTTGCCCCCTTTTTTCTCCTCTCTCCCCCCCCCCCTTCCCCCCCCTTTTTTCCCCCCCCCCCCCCCCCCATTTTTTTTTTTTTTTTTCCCCGCCCGGGGTGTTTTTCTCCCCCCCCCCCCCTTTTTTAAAAAAAAAACCCTCTCTCTAAAAAAAAAAATTGCGGGGGGGGGGGGGGGCCCCCCCCCCCTTTAGGGGGGGGTTTCTCCCAAAAAATTTTTATTTTTTTCTTTTTTAGGGGGGGCCCTCCCCCCCCCCCCCCCCCCCAAAAAAAAAAATTTTTTTGTTTTTTGGGGGGGG + '$(-,-4-)'()**'/4+7*+**,()8)(4/16458AAEAD?368/1:14489>5*-13;@::8D>>>>8>BABB@AAAF?AAA?=@BBA=??A@AAAAAAAABA=@=:=<AAAABA?==>D>?AAAA@=@@=BF@=8<6+,(../@ACBBEAA>44718:ADA@;;99:7:DBC650)2+7AAAFFAA????<;?<??C@@@@??A?A=<==8=AB@?C:6,>==;<<5<=AA?A<<..3,78@==B===@AAAAA@???@AA??A?ABAEEAABBBA?A?A=@@<;9@?ABFBFEBBAAAB>;9453054;B?A05..87=A?=AABAA9:A?A;E6<<9>==AAABAAAA???CAA?=====??=>@=<<8;?=A9:3;;7EAABABAEAAA566:69A==@@EAA=@==@EDCAAAA>====?====:=AAAA==B@===>=@@9:=541.52371=E@4;;9;4@>@>=@?=55666)*,(),--/@;?@120,*)-**./:11(*(++')'.+)'&&&&&'''+)*)+')01-04**(,-2,,**-,.*./52./62722--++,)-(*.2+()+---3//1**2986.0-3-+.-*''()-',.((%(,%*,))))))))*42/05<-24*%+(..*+0+**.62,011+))*+,+-,)*+.-,,())),+)('))*,**))1201.)/52.**+'.-*)))')).40***562/,,,)000,07:DBC0/,,+,))+&-),())).)*+++)+'(&.&.-0>66,*-)1++'-+)*(*+14.,))*(*.),-1772***%*.2,,*&&&%,(()()(,+-**)()*,,7463)*&)*+-.:17DD3+)))))))))*(**'()&&))&&*)(%)()1/*./-'*%(,+2.)&...+)))'+*'&&)))()*1,-)(+(+**,.+))&&'+)*))2.-.2*.**-('))&))**2+,*)&+((()))-))%))&))))))))))$$--0)))')'&)***&)+((((-114*2-+*))$)),(),(&**086><6.-*,)+65=D76),*16/)))+*'*(+*59/.())**.++$--1DE5/-,-)+)(*,,0+,.3)+*+)&&**+**-,-/*./+((()%&++988A8A774.*(&'(+()))-)*0,%(***-.*2-02<BB>94*())))')(')41+/****&))'+'++,*)&(+,,=/-)(()+-()),2A@ED5<A0;2*(.*)53@;23,*-*%)))3285,+**,),**)(*(((,***.&*),,-**%1289,(&-*.*)**,,.%*..3-)+*,+)))*)).0*&*,/5..*)*'*(-,))))))*)0))**,)-.6 @122533c.t3 CTTGCGTTATTAAAGACTTTTTTTTTGGTTTTTTTCAAGTTCAAGTATTCTTTATTCAAAGTTGAAAACTGTACCATACTGCATTATTGCAAAAATTCACTGGTACAAAAGACTTTGCAGCTGGTGAGAAGGCAATAAAAAGTTGATTTTTAAACTCATTACTATAAATTATTCTTACAGTACTTTGCAAATTCAGAATTTCAAACTGCATGTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAACCTAAGGGCAGCTGTTTCTGAGGATGGGGAGAAAGTACAAATCTCTGAGGATTTCCATTTCTCCTCCCACCTCTAAATACTCCGCGGCATCTTCCTGAATGTCATATGTTGTGGGCAACTTCTCTTCACAACTCTGGATGGGTCTCTCTGAAAAAATACCTTTCCGTTGAAACTCCGTTAACCTTCTTATTTTTTGCATCCCCGTTTGGATGCCCCCACCTCATCGCCAAACTATTTTTTTTCCCCCTAACTGGTTGCAACCACCCAAAAACTTTGTTCCACTACCCGAACCAATAACTTCGCCCCTATGGCCAATCCCTAAAATGATTCTTTTTTTTCCGGCCCCGTCCTACCCCCCCCTGTTGTGGATTTGGTTTTCCGCTCGCAATTCCCCCTCGTTTTAAACCTGAAACACTGAGGTATAACCCCGGGGGTTCCCAAATTAATTACCTCTCCCACATTAACCCCTTTCCCCCCCACTGCCCGTTTTCCAGTAAAAAAACCCTTTCCTATCCCCCCTCCCCAATAAATTCCCCCCCCCCCCGGGAAAAAGACGGATACCTTCTTTTGGCCCCTCCCCCTCTTCCCCCCCCGTGTGTTATTGTTTGTTCTCCCGCCTTTCTGGCCCGGAAAACTGTGTTTAAACTCCCTCTAGAGAGGCGGTCATTAGGGTTTCCCCACATTCCGGGGTAATCCCCGGTAAAAAAACTTTTCCCCGGCGCGCCCCTAAGGGGGGAGAGAGCCCCAAGGGCGTTTCTCACAGTGTTTTCTCTTAGGCCCCCCCCCCAAAAAAATAATTTGGGTTT + &&$)2*(1/*532-))&(.7AAE72&*,&49AA>;=@;AAABA636166?A34566;:57<?::@74()+53857=DAC=@@AAED@>B??;;<???@A@@D@@C@A81)(*,64=?A;/>>>??9=.0.*.17:=@=@?;;818;??@A?CDDAACF@>=9??ACA<C?C@<C?:>@@@@;?73/88.07C9;/2618?ADAC@@AADA>7>+8;7A<7:4?C@@B@CDDA98*.34A643057698-+24,/*-.),*)((()'+933((1*0,),1191)()212//---*(/)%(),*+.0.222.-211****----*%,&..//-**%*)%4:05993-;7<23)(*11,)))++))*(,/*,.,10.2.()1*(*/)***,.42*-)(3*-<,*,-,*52,*4.-/,(-**)*0))'+$)/,.;:0-4+,-*,,*0421/-,+5,(*)%..+0*+/(),5/33*)(+*(()),)**(+,,5:9*(**)**-,*))*(.*,.**)))**,,**9>7+**)**+.*)'')%(),)++.-*+()(,**)*,+,3.-3//464=4-79)/5;.*)***(++.((/,,3..559/+)(*,*++*,))(-**)**+,)))(-))*/-*,,*,)*+),--2+***,*+)&2731-7/,-*)*-*-/*))**(**-,-9-01*,-+**)/53*-,-***.-))*(+**+,)++++)()*01*0+*-1.-+*))*+*+,)*.0**,(%**)))+--)*.&*++,(()())27+*++*(*,*+++**+,;4/*-53,0()((*+6++*(())(+)(,')-)))(*)(/,,)))++*+*0+*1156-*(((.-****+1)**+**))'+))**+*-,)()-47776;30.),00,+))0*()(*)+++,+(*+*))++*)%*(&%1**,/1,**).**),*)),**+))**13,+)))),***)%*.1:8;;)*..5551-/-,.,-,+)*-33-*)))),**-),10*())*))))*0+*)-001/*,)*+,+20>;::950526/)**-))*+*()*,,, @122533c.t7 ACTGAGCAAATCGTTACGATCAATAGAACAATGATTTTGTGGTGGATGCAACCCGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAACGGTGATCACAGGATATGTATTTTTGCCAAGAGAGCCATCCAGACTGGCGAAGAGCTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTCGGCATCGAAAGAGAAATGGAAATCCCTTGACATCTGCTACCTCCTCCCCCTCCTCTGAAACAGCTGCCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAGAACATGCAGTTTGAAATTCTGAATTTGCAAAGTACTGTAAGAATAATTTATAGTAATGAGTTTAAAAATCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACAGTGAATTTTGCAATAATGCATATGGTACATTTTCACTTTGAATAAAAATACTTGACTTGAAAAAAAAAAAAAAAAATCTTAATAACGGCGCAGCTATCCTTATGAGGTATTTACTGGCCGGCGTCTTACACTCTGATGGAACCTGCTACCACTACGCTGCACACCCCTTCCACTGCTATACAGAGCCACATCCTCCCATGCCACGATGCATGACCCGTCGCCTACCGCGTTGTGTCCCCTACTAATCACCCACCGCCTCTCTCTCTCCCTCCGTCCTACCATGGGCTAGTCATTCTCGCCACAAATATGTA + ''&$),-0.,&'&)('))--(('(('..1874E;8;=AAAAAA;9A99<1849;>6*/24<;:6=>;9474;?BBA@AE@AAAEAA?ABBA=@@@@?AAEEAA@@>=@===<=AAABA?>====?AAAA@@@A=AA@=:<5-++..-?@ABBAA?:2,7-736B;?892.9:7?==66/)1+3?@EEEEA@D@@;B>8=@D?AF@?AA?A=AA?A?AA??<:6,;6=6661994<=:99.,3,97:=:====?@B??=C>5C@?EE??A?A?AAABBABAAAAADAD??C@AAEFBAEAAAAAA==;520/05.@9@23.+658;;5=8?<;:=:@@9<4*55::=AAADA?;??>CCA?B====BA?A?AAAAAAAAB9:7<88>==AA@<AABA25.1,76=??CB?D<ABABAEAAAAAA@@@>?=;@=8=4;33431..89@=E>10(*1.A7>15,*46AA>8=E;22,,,,,/-4250:E43273E-30/200*23+1/,+),+*/1=77+*659<2758.,,)*.*)(&'(',+2+.,*.*(.(/.2-8/*-3-3-1=4;:0+.***033-/+,/*0)2.+,)&),,6,/,0%-//33..)))+86.-),(*5133//.+02%-1/9+01+-,*,))*)+,.))).)),-*(26;+3--1,.((,+-/--7//7,0,*8.70*6-%.*)))(+,1)102),)(),,-,28@9<*),1**<=96,***(/36,-+(/9+,,*(+)*0.9;56++-,+.) @230375a.t3 GTCTCTTTTTTAGAAATTTTTTTTTCAAGTTCCAGTATTCTTTATTCAAAGTTGAAAAATGTACCATACTGCATTATTGCAAAAATTCACTGGTACAAAACACTTTGCAGCTGGTGAGAAGGCAATAAAAAGTTGATTTTTAAACTCATTACTATAAATTATTCTTACAGTACTTTGCAAATTCAGAATTTCAAACTGCATGTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAGCTAAGGCACCTGTTTCAAAGGAGGGGGAGGAGGTACCAAATTTCAAGGGATTTCCATTTCTTTTTCGATGCCGACATACTTCAGGGCATCAGCCTGGCTGTATCTGTAATCAAAAAACAGCTCTTCGCCAGTCTGGATGGCTCTCTTGGCAAAAATACCTATCCTGTGATCACCGTCAACCATCATAACTTTTGCATAGCATTTGGATTTTCCGAATTATTTGCTAAACGAATTTTTTACCCCTGGCGGTTTGCATCCACCACCAAAATCATTGTTTCATTTTGAACAGAAAACCGCACATTTTTTTTTTCATTACAACCCCCTTCCCAAATTCTGGGCCCCAAAGGGCAAAATCCCCAAAAATTGAATTCCTTTTTAAATTTCCCTAACCCCTTTTCTAAACTTGTTTCCCTTTTTTTAAAAATTGTTTATCCCCCCCCTCATTTCCTCCCCCACCCTTTTGAAAACCCGGAAAACCTTAAATTTTTTTAAACCCCTGGGGGTTCCCCCAAAAATTGTTAACCCCACCCCTCCCCTTAAAATTGCGCTTGTGTGCGCCCCCCACATGCCCCCCCTTTTCTTAATCGGGAAAGAACCTTTTTTTTCACCACTCTTCCTTTTATAATAAAAAAAATCCGCCCCACCCCCCCCCGGGAAAAAAAAAGGGGGTTTTCTTTTTTTGGGGGGCGCCTCTTCCCCTTTTCTCCTCCCTCCACAAAAAATCTCCTGTGTGCCCCTCGGGTGTCTTTTCGGGGGTGGGGGAAAAAAAAGGTGTTTCTCTCCTCCCCCCCCCCACAAGAGGGGGGGGGGTAAAAATAGGGGTTTTTCCCCCAAAAAATATCTGGGGGGGAGTAATAAAACCCCCCGGGAAAAAAAAAAAAATTTTTTTTTTCATCAAAAGAGGGCGCCGCTCCACAACAAGGGGGCGCAAAAAAAAAACTCTTATAAAAAGGGCGGCGCCT + $&&+&)&))+)('+'$&.3AAAA??==736).*()1244=A@8;.&028=@A6:@;?==;>=:5==?AA?A?@A@DG<AAE?===:8DA@???D===@?AAA??==CBA???A@;<</752:=@AAAA=@;2;52@?@AAAA@@@@CEBAAAAAAAAAACAA9?@>AACC????:;@<<<CD5;:*:7:??AAAAA??D??@AAA@AA@@@@DDAAA@A@@?::>8;788*/*461@96/725;>9<=,+-&+*,B=>A97<)1.*7640/),/*./,)2--16,41/6.315:8>D@AAA;9/()533*/39==;:12866<775886?C;;8A8;13-192;,6;9?C>4;=@B@@E8553????7:059/+/-,,,.02638:6931342::==811,.,2,5/,-2)*/1**0,,)*.*,**)*55494=>?65*31%**,017535/-%*/.5/*,,*2,*,%+++2&-)*+1)+50746.**2,,/*+2***2/-*5*)*+05201,))1+))%()$.2.)0.1-%12;00-*,*7**028<6:8,2-()())))(**+0/6/66>B52..-*55;71.-*)0/,-*+5++*1**'*,51**)+&++***,.=503-,*(3+)25).5/,)++,'%))))(+)++2,,+((),,0+)))))(((,)()))).1/./0*-/,4**,,0/6+,())),.,)$**+/37-1,.))(+)')/+*..00+)(.-).22*%0642**.+33+**)),+)**/(**,*))),+)+*-,+()+(*+1+))))(,-++$(-++)+.1*)))(&*)++,+*+032*-(%)&*(*,,,)+$))))*..6/.+))$+)%(&/&*),+.+),,)))'(,*(**)(++*2*+).)),9@A1,)****,****+))&)')%+-/20,034/+)-1-/++,--)20-1)**)(1--+-(')+*+$)),)+240,,-+-+*+))1)*))*,*).+,+*-+,200--5))++))694-10760-)++)*-0-*+)(-+(**--/*)**))')))+0))**+'+**)'''&*-,*+*&)**+-//1-*++/+*,***-+-,202+))./1**2),+,39;52,,*+)))+)/65*))''))7797-**(*()**-,--//2/***..*79,&*&(($)--+.,*,*---30C*))()))+(*)+)(&)*())))***2 @230375a.t7 TTCGAAGGCAATATCGTGACGATATGTATGATAAATACTGTGCAGCTTTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCCGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAACGGTGATCACAGGATAGGTATTTTTGCCAAGAGTGCCATCCAGACTGGCGAAAAGCTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTCGGCATCGAAAGAGAAATGGAAATCCCTTGACATCTGCTACCTCCTCCCCCTCCTCTGAAACAGCTGCCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAGAACATGCAGTTTGAAATTCTGAATTTGCAAAGTACTGTAAGAATAATTTATAGTAATGAGTTAAAAATCAACTTTTTATTGCCTCTCACCACTGCAAGTGTTTGTCCAGTGAATTTTGCATAATGCATATGTACATTTCACTTGATAAAATTCTGACTTGAAAAAAAAAAAAAAATTTATACGCCACTACCTTATAGTATTACTGCCGCCTTCACTTAGGAACTGGTACATACCTCACACACCTCCCTGGTATACAAGCGCCATGCCTCACATGCCCTTATGGATGGACCCCTTCGCCTTACCGCGGGTTTGTGTACCCATTACGTACTTGCCACCCTAACCCCGCTCCTTCCTTTTTCCTCTTCCCCCCATTCCGGGTTTCCCTAACTCTAAAGTGGGGGCCCTTG + '%)&=995+)+(+)+))*(.).*+//0,.2===;9/3*/67A@A8;4.:?DD=====A>9====@>>:C:=AABAAAB===68>::>>=?:-.44:????B==::8=@CAA<A?@A?AAAA>===A=AAAAAAAAA?AAAAAAAA@@@AC@BA======A@@===:=@=>A@;:C3/-*326?@@AAEA>81'.%&*,5;<884)937==A@;:,6,6?AABEEAGB@@;;:94=A;AFAAABGG??>===@DAAC@;1;6965:19::B<?A75/1/5A?AAAAAAFAA@===:=8@?EAAAAA?B=>@=AA??BA@E??E<=9<8?BBBEEAAAAAA=:3377268;;;;/8+.584;;4==@>A==:==??9:3376;====A@=?====??===>?==@==E@?A?7;C?<5*7249@?BAAAA?AA?<?7399;?AE@==?A@AAAAA@A;<,,(+,0@6.2103**.+366601-)+/8@;:==E@==>?<;9772,341::30,14:64))0-820,*,,()'(..-.,4:?9931/52*))*,)))*-*14,*(01(*./1,++/36522<89.*-.,-*&2**(**/1.,++)-.-+,.,,(%++1+%+--,,(.,(00/+&+0.+3,,*+(.+,,-03/.,++)((,0,+1..+622*,-)(+*+1+++-++('.0*),&()*/.(*+)*))0(),,*((-++)+('02*//.--)(%((*,2/1..-,8),/-*((,+*,*2.+*(+1+.20-.,,)+))*5..0*-+,/*' @230375b.t1 CAATGGATCCTTGAATCTTCTACACCTCCCCCTCCTCTGAAACAGCTGCCTTAGCTTCAGGAACTCGAGTACTGTGGGCAATTTAGAAAAACAACATGCAGTTTGAAATTCTGAATTTGCAAAGTACTGTAAGAATAATTTATAGTAATGAGTTTAAAAATCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCAATAATGCAGTATGGTACATTTTTCAACTTTGAATAAAGAATACTTGAACTTGAAAAAAAAATAAAAAACCAAAAGATCTTTATTTAACCGGCCGCAAGCTTATTCCCTTTAGTGAGGGTTAATTTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX + ''*,32+,1/4(&)(033,.51,(*01B=@@=AA?@@BB>=383*>8<A:628<=;6<<3..'*//86*443=????AAAA@A8;,;82;2)2.4:;AAAAAA:C:7??ABAA?????EE@@?????;BA1;4948==AAAA@@ABG?@????@A@>??A<A==DA@BA?D@@AAAA@@??>84.+;<AA@@CA>?>>C<@;@4;3*305:;;@=696554>@@?CC@==>===DAAAAAA@C><A=6;==98?<?>>1426==8:::<8-,'+,.A=92/-+39;+,*'2&))152435/8B?76)516>=B?>??C>>?BABEEAAAA4:33;=9@?A@=<43!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! @230375b.t2 GAAACTAGAGTCCTGTACTTAGCTAAACCTCCCCCTCCTCTGAACAGCTGCCTTAGCGGCAGGAACCTCGAGTACTGTGGGCAATTTAGAAAAAGAACATGCAGTTTGAAATTCTGAATTTGCAAAGTACTGTAAGAATAATTTATAGTAATGAGTTTAAAAATCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCAATAATGCAGTATGGTACATTTTTCAACTTTGAATAAAGAATACTTGAACTTGAAAAACATTAAAAACAAAAAAAAGATCTTTATTTAAGCGGCCGCAAGCTTATTCCCTTTAGTGAGGGTTAATTTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX + +)))&()*,)&)))')*))))+/,*,,-12A?<77>A@A<7/.&**)066A9?89,2-*11263-133:*30155DC=BE@?@??@@@9@==@<865:9=DD@@D;;?===?;@99;7;;?DA@@@>????A?BA:<:;??AAAC@A=B=;??DA?CEF@AAD@CA@ACAADBEA@????ABBAA@@AACABF@>DDA@@=????>7;2*658=<AA?>=?==?ADC8>82?86?D@>@@?>??>???@;:9:=::=9:3<57AC===??A;3,/)%%)*&*-),''//..714,))(-1,7773-/;/**.5---2=8???<999=A?A<46525-1697?<<>==A>!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! @230375b.t3 CCGCGTTAATAAAGGCCTTTTTTAGGATTTTTTTTTTCAAGTTCCAGTATTACCTATGCAAAATTGAAAAATGTACCATACTGCATTATTGCAAAAATTCACTGGTACAAAACACTTTGCAGCTGGTGAGAAGGCAATAAAAAGTTGATTTTTAAACTCATTACTATAAATTATTCTTACAGTACTTTGCAAATTCAGAATTTCAAACTGCATGTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAACTAAGGCAGCTGTTTCACATGAAGGGGAAGAATGTACCAAATTTCATGGAATCCATTTCCCCTTCCAATGCCAAATAACTCCGAGGGCTCCACCCTGCCTTTTCTCTGTATCCAAAAAACCCCTCTCGCCCCCTCTCGGAATGGGCTCTCGTGGAAAAAAAACCATCCTCCTGTAATATCCCCGGTAAACCCATTAAAAATTTTCGGCAAAAACTTTGGTGGGATTTCCACGAAATATTTTGCAACAACCAATTTTTTGTCCCCCCCGGCGTGGTCTGCCCCCCACCCAAAACATCCCTTGCTCCTTGTTAAAAAAAAAACGCCCCCCCTTTTTTTTTTCCAACCCCCCCTCCCCTGCCCAAAATCCTGGGCCTCCGGAGAGGGCGCAAAACTCCCCCAAAGAGATAATAGATTCTTTTTAAATTTCCGTAAATCCCTTTTTCACACCTGTGTCTCCCTCGTTTTAAAAAGGGTTTACCCCCCCCACAATTTCTCCCCCCCTCCCTTTCTAAAAACCGGAAAACCCTATAATTTTTTAAACCCCGGGGGGGTGTCCCCAAAGTAGATTTTAACACTCACACCCCCCATTTAAATTGTGCCTTTGCCCCACACTGGGCCCGCCTCTTTCCAATTCGGGAAAAAACCTTTCTTTCCCCCCCCCTATTAATATGAATCCCGCCCACACCCCCGCGGGGAAAAAGAGAGAGGGTGTGGTGCAGTCTTTTGGGGCCCCCCTCCCCTCTCTCTCCCCCCACATAGAAATCCCCTGCGGCGCTCTGCGTGCTCTCTGGTGGCGGGAAAAGGTGTATACTCTCTCTCCTCCTCAAGGGGGGATATCGCACGTGTGTCCCCCTAATCTGCGGAGAGATACCCCGAGAGAGAATAAATTTATACATCATCAGGGGCCCCAATGGGGCAAACACGCCTATAGGGCGC + &%()()*1++/321((++-.1+&+'''&,?EE,AE?AA>665&,)((2/+%''))-+,023--2.,3*6665,265=7=?AABABABB?=@===?;>;=@@ABAAA??AAA?=A:7<9D??A???AAAC18;6;;ACE@@@@B7<05;;?@A@A??@A?:<<A@@D@@AAA?>99?@:AAA@A?A?=;????AA599*848;AAA@AAAAB;:7:2;@?BBA??ACGGABCDA=??=;;==<,;24?7></9;5650/24.13)4,.772-.%+&.,/0:;222),,'()$))),+.+*,,(,.,+)*-((0A1,2150*(**&+*,,,,+*)*-''-++*0,*,.323/*+)*)*+1())*)*+*..3;9/-/%(()))*,)-12/**.4.*-(()+*)5415((()(*03*)2**)*+()*,+)(),))()(**.-0+(+()()*()),.//*/<++-030.+*,**()-(*)*)()(*)))'(),,)++)(+*+*(*,()((),+5420*()+176;1./32-))((..()0/;8121-)**))(***-()*&),,)**(*)(36;@@@5/*))/-,;722335@@::6*+**3,,-,+*-*1***+))()(25,+,,++-2./-,+*..6-5-.,/+)*0+-..)+.4/*-,*''')))())*,*,+-+*,/.-*/4<+*,,+*(//,,0/-*()**(**++))+.)),*))),,23=3.+()(,***.34;96-*)*+,+24,,*,,15472-**935(250/1*-.***-10<2*+,++,.))),2+.=2?3/1832-+*/*))+*)')+'-())()(())''(&+()+,--.-**,1.:57,)),((*+23-1*.()((''()'**)+*(*,,-))***)+&(('+))21())(()))**-6-/.<1,**()))+0+,'&&(())*(()))))+0))),*(,()))+**,+*+%)(),+((+'(*)(''')145))(+,+,++,,,)**+*08...051..+.-,)+')((+)'()')+1***%(+--+/+))((()*),***,51./1,(*,11--1,,&%*)*,**(+++))'(7:/,,()(),&)'''(),))(),((()(&(,*/*),*-&**+)))),..2-+-+,,-,*)+(((,/,((((,+))(&+*0+*+))))(()+'''('))(.(*)*+++- @230375b.t7 ACGAGCAATATCGTGACGATATGTAAGATAAATACATGTGCAGCTCTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCCGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAACGGTGATCACAGGATAGGTATTTTTGCCAAAAGTGCCATCCAAACTGGCGAAAAGCTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTCGGCATCGAAAGAGAAATGGAAATCCCTTGACATCTGCTACCTCCTCCCCCTCCTCTGAAACAGCTGCCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAGAACATGCAGTTTGAAATTCTGAATTTGCAAAGTACTGTAAGAATAATTTATAGTAATGAGTTTAAAAATCCACCTTTTAATGCCTTCCCACCACGCTGCAAAGTTTTGTTGTTCCACTGAAATTTTTGCCATAAATGCCGTAATGTTCATTTTTCCCCCTTGAAAAAAAAGAACTTTGAACTTGGAGCCGGTCGCCGTGGCTTAAGATTTTTTTTTAACCGGCCGCGAAGCCTTATTCCCCTTTAATTGAGGGGGTTTATTTTTAAACTTGGGCCCTTGGCCCCCCCTTTTTACAAACCTTCTTAAATTGGGAAAAAACCCTGGGTTTTCCCCAACTCTTAACCGCCTTGGAAAGCAAATCCCCCCTTTTCCCCCCAGTGGGGGTTTATTACCAGAATAAAGCCGCCCCCCAATTCCCCTCCCCAAAATTTTTCCCCCCCTAATTGCAAATTGGAACCCCCCTGTTACGGCCCTTTAACCCCCGCGGGTGTTTGTGGTTCCCCCCCGTTAACCTAACTTTCCAGCCCCCAACCCCCCCCTTTCCTTTCTCCCTCCCTCCCCCCCTTTCGCGGGTTCCCCTCAACCCTAAATGGGGGCCCTTTG + ''$,.--+'+)*'')'.)/*+01*,-+99>AA>>>>===?B?7<1*+?9?AD==A=7.5954=>B:@==AE?A?A?EBA??B>?@DAB:5597:?;?@?AAB??DFBBE?AAAAABBBA=====BEAEABBAAAABBBAAAABCBB8B?AA=:===>AAAA?==D==>C?838---*.05?BEABA@@<8/.&(*-99=805)1-6<==553-.*57ECEAACC@BC?;>:8>@<EBAAAAAA=<C===@AA?883*9.22754:9?A??89.-2.=;;==@===F@AA??==7=B@A?@>@?A?ABABBBBA?B?AB=>=B>??BAABBECC>7??;33-43,22.?=>/8-/0/3360A9@=@747:7:;88;=:==AAAAAACC===A?=@=;:=@??;>@>?A87=876-)/,-67>@AA7@<<=@;1,,-14>=?://)((,())211*-5*0*+,***)+++$+.,3,.6'/))-&.+-9020)).++/0),,5,)())),.*,-..(*((),()*,/438,2/./*1.*35+.21,,&+)()'*(,+**))))$'%$$$$$$$$$$&&&('))))*-36-*-,)&(*/1*,)*()/)*(+*--*483181-/,/-,1**5;+)****,*)*((&+(*%*5**+%(++(+-06:75;2-0)**),,*)**++***))*001-0..**.,()**.8;BA-.0)))+$))))(+*--*++****)))))),,4530.*56.//9-*%((**-+.,-/)+))-+.%*,&,+)++-)'))11)((+*.66/,.2-,8511-...'&)4:1-((/+)))((,,))(+*-,/68.-)%++'*)+*+,*----*.+*(,),+)*0+)--.)))(*,>9/**(+*+%**-/1+02**--(*002-+0/032/*--/5**-/)*,()1,-)+11))**+*&+.,*).),++.++*.,03,()))*)*,)74..*,,4))/ @230375c.t3 CCGCGTTAATAAAATCTTCTTTTTAGGAATTTTTTTTTCAAGTGCCCCTATTCTTTATACAAAGTTGAAAAATGTACCATACTGCATTATTGCAAAAATTCACTGGTACAAAACACTTTGCAGCTGGTGAGAAGGCAATAAAAATTTGATTTTTAAACTCATTACTATAAATTATTCTTACAGTACTTTGCAAATTCAGAATTTCAAACTGCATGTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAGCTAAGGCAGCTGTTTCAAAGGAGGGGGAGGAGGTACCAAATGTCAAGGGATTTCCATTTCTCTTTCGATGCCGACATACTTCAGGGCATCACCCTGGCTGTATCTGTAATCAAAAAACAGCTCTTCACCACTCTGGATGGCTCTCTTGGGCAAAAAATACCAATCCGTTAATCACCCGTAAACCATTCCATTAACTTTTGGCAAAACCAATTTTTGGAAATTTCCCGAAAATAATTTTGCTCAAAACCCAAATTTTTGTTAACCCCCTGGGGGGGTTTTGCCCTCCCCCCCCCCCAATAATTCCCTTTGTTCCCAATTTTTTAAAACCAAAAAAACCCTGCCCCCACTGTTTTTTTTTTACCATAAACCCCTCCCCCCGTTGCCCCGAAATATTCCTTGGGCCCCCCAAAGGGGGCCCAAAAATTCCCCCAAAATGTGGGAATTCTCTTTTTTTAAAATTCCCTAAACCCCACTGTTTTCCCAAAACCTTTTTCCCCTCGTTTTTTAAGAGTTGTTTATATCCCGCCCCCCCTGTTTCCCCCCCTCCCTTTTCTAAACCGCGGAAAACCTTAAAAGTTTTTAAAACCCCGGGGGTTCTCCTCTCCTAAAATATTATACCCTCACCCCCCCTTTATAATTGTGCTTTCGTCCCTCCACACTGCGCCGCGTCCGTTCCCATTTCGGAAAAACACCTTCCTTTTCCCATATCCGCCCTTAAATAAATCGCGCTCACACCCCCCGCAGGGAAAAAGGGGAGTTTTTTATTTTTGCGGGCCTCTTCCCCCTTCTCTCTCCCCTAACAGAGATCTCTCTCGCTCTGTGTCTTTCCGGGTGCTGGGAAAAGGTTTTCTCATCCCTCTCCCAGGGGGGGTTCGGTGTTCTCCCATATATCGGGGAGATATACCCGAGAGAAAAATCTTTACACACTAGAGCGCGCCACAAGCGCGCAAAACTCGATGAGAGAGGGCGCCTCTTCTT + &%()&)*0+,)+(*))())()(++.*+.),AAAEFBA7;@:89&5'''312*7<573)-))99A98),)23=5783486??=@==@=?AAAAAAA@;:;;;AAAA@@=>@AA????@AB@;;?ABA=;?:40614:CBC?;,--2-++.2CEFBBFEAAAAAA@@@A><<C?=C<9?>5?=@@????=;A<9<?D2;>.>;>@ABA@@DDD@::8;5;C<=A?A?A?=@=A?CA3894;;855*2*/66<:,*.+-347;8508*9..=6<B:64*0.-56643/,*(+-.+82)34+2,+**328<2/;5?/5-62:A;69-4+,?A6?:96438=749:75<<30+17.2-6049/:22;9==9==B?D=33/(402405)*)*)()*,./0/-,)*,+*.*,-+-+/2//))*).*)6**.,,*0--,/*))*,/)****)(()(,*(*.-,+*(*+.-(),++857*11,*)00,**))+-*)*((023-*,*+**-+**),,*.65.))))()-.1*(*)+**,.2**,+****)*+7955820+)*)$*)*+1-++0*),/,/+*),5;:96:485++,7?C861/-,))*+*+*,)*)+0/485,))&))))()**++5)**-**,****)*+-()2..1,+**(**-*+39+*,(,,)+311+,+,5505)+).43,*)*--&)+*((++)*)+,)528;?523+*66.-21,72-2201)),/**-(''(,3)))(((--0.,,()*(*+25,*''.&(***-)0,-*+216,--84+*)**+-1265,.2%+*/1252*+30**+.,.*,./-,/,./+++')))..+-0)*+,,+-+4,**&)++.((()*)//0+),)*)*-,/-)*++*00-/,1..6///1--+*++)))'''*.))**&+*4).*+,))()'$)))***../)**,40+))()))+))**.3;-**.**(((*))13***+,-*)')')+&*(*)))052,))))))+++.,****&/.+*)(,..*+*,,.)()**,0***,12)/)+++3.+,**)%')&+,,)*+*+*)&))&+*-,/11.****,*+)')(''+***+*'((*+)*)))'))(()****(+)+5.0.((***())/+-1.,,((,,'()')*))()/,--)),,(-*+,,++)''(.'')+,)+),*)*+.,+(+)(''+.(2*))(,+')+()+,,6?++(((*)+)')'(((* @230375c.t7 ATGCGAGCAAGATGGGACGATATGTGGGATAAATACATGTGCAGCTTTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCCGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAACGGTGATCACAGGATATGTATTTTTGCCAAGAAAGCCATCCACACTGGCGAAAAGCTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTCGGCATCGAAAGAGAAATGGAAATCCCTTGACATCTGCTACCTCCTCCCCCTCCTCTGAAACAGCTGCCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAAAACATGCAGTTTGAAATTCTGAATTTTGCAAAGTACTGTAAGAGTAATTTATAGTAATGAATTTAAAAATCAACTTTTTATTGCCTTCTCACCAGCTGCAAATTTTTTGTTACAGTGAATTTTGCAATAATGCAGTATGGTACCTTTTTCCACCTTTGAATAAAGAAAACTTGAACTTGAGGGACCCCCCGGGGCCGGGTCTACTTTCTTTTTTTTATGCCGGGCGCAAACCTTAACCCCCTTAATTGAGGGGTTTAATTTTAACCTTGGGCCCTGGGCCCTTCTTTTTTACAACCTTCCTTGACGTGGGAAAAACCCCTGGGCGTTTCCCCCACCTCTAATTCCCCCTGGGGGAACATATCCCCCCTTTCCGCCCAACTTTGGGTTTTTTTACCAAAAGAAAGGCCCCCCCCCGATATTCCCCCTCTCCCAACATTTTTGCCCCCCCCTTAATTGGGAAAATTGGGACCCCCCCCTTTTCCGGGCCCTTTATACCCCCGGGGGGTTTTTTGGTTTTCCCCCCCCCTTTACCCCCTTCCATTGTCCAAGGCCCCTTAGGCCCCCCCCCTTCCCCTTCTCTCCCCTTCCTTTCCCCCCCATATTGCCCGGTTCCCCTTATAACTTCTTAATTTGGGGGCCCCTTTGGG + '&$).35,1-%-)/)'*,(-/++3-,+*2.=9489;:;=>DAA17***9<@CC?@=;3+/174@:=;?::BAAAAAAD??;@7/1:9?A915256;::@;BDB??AAGAAABEACCAAAA>@A=:?5>AA@F@?D@AAAA@CDA><5*873?9====?A>?;9;5?===@C:0:1..)566DCCCC??8A8./+0,4?97212.3.6@==956*/.6CCAEEE=@??;88241:=?BCA??A<AA5:@>B@DAAA?;.<4334.,1469:5709,3,3:<====>=F@CB?D==55BBGA??????AAABB???C???CB>5848>>CCDAC>8.10*)12/7767958,1&&..48,*22=:A?A==;=@@?E;7::9?=<=AA>9=/.-+*+1/63778401.06<0,1*)(1*).%&.4?A84,*(/3.4*-,133.++*+)***1139544,/**+'*(&0-27(&,)'-*2*+**343((.)-*-+*3:1..('),1/,+*))(%)'+(**(+(,534(),))+596-/2,20<041)+-,2)-+)+()*&&(*.*,-&&&&$$&&&%%&&)*&'),*122*,-0*.&*(*.+()*(*-)+,,**)*643()0*,-***/0/4.+-++,39<4+,**)024,,,)+-,,0-()*(756,+)()+(')***-(()))+++--2365.1/,+++))'+-+(-33*-'),')),)+,,17-.+,+(()%$)()+)+/?D<,0.(++50++%),()22+&-3.*-*))+)-00,0-,,+*+-,2-571(*.)**08-+)))))()**)+,+3,,**64A8984-/1++-+,++1+*-(+0)**.5664-+3-0+*-,,-*..,/*,)+*/77-2,1))))+*2.*))**+(*..24-*+*,,--****(*''''),)('(*(&()+)))&.(),356;886-4.,.)))'(*,)+,***(112*))),*),(%.&,*)))(,/09./,*(()+..)&)*)(***)%,**-****(,,*)** @U13a03c03.t1 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTTAACAAATCTCATGGTTTAAAAATTTCATAAAATTTCTCATTTCAAAAACGAGAAAATTAAGGCCTTGCGGGGTTAAATCGTTATCAAGTAATCAGTCGGCTCACTGCCCAGTGTGGACACTGGCCAATATTATGGCACCAGCCTTTGAGAAAAGGAAACCTTTTTTTGAATCCATCTCCCTGACCTGGGGTTTGGGTTGGGTTTTATCACCATAGGGTGACAGGCAAGTTCAATCTGATTGGATCCTGGATCCCATCATGGGGTATCTGTTCCTAAATCATTCCCTGATCCTCGGTCAGAGCGAGCGCTTAGGTTCCCGCTGCAGTTAAACACCTGGTTCATCTGGGCATACTAAGGTTATGACTTTCCACCTGGGAGTCCACGACAACTGAAAAAACTCAAAACTTCTTTAAGTAGAAGTTGAGCCTGAAGCTGAGGCAGCTGTTTCAGAGAGGAGGAGGAGGAGGAGATTGCTCATGTCCAGGGATTTCCATTTCTCTTTCAATGCCAACATACTTCAGGGCATCAGCCTGGCTGTATCTGTAATCAAAAAACAATTCTTCGCCAAGTCTGGATGGCTCTCCCTGAACAAAAAACACCTATCCCTGGTTGAATCACCCCATTAAACCCAATCCCTAAACTTTTTGGCCATAAACCAATTTTTGGGGAATTTTTCTCCCAAAAATTGAATATTTTGCCCAAAAAACCGCAAAAATATTTGTTGTTTTTAACCCCCCTCTTTGTCCCCGAGGGTGTTTTGCCCTCTTCCCCATCCCCCTCTCTAAAAAAAATTCATTTCTTTGTTTTCTCCAAAAAGTTTTTTGATAAAAACAAGAAAAAAAAGCGCCCCGCCCCTCCTCATTTGTTTTTTTTTTTTTATTTTACAACCACACCCACACCTTTTTTTCTCCCCTCTCCTCTCTCTCCCCCTTCTTCACCCCCCTCTTTTTCTCTTTTTTTGGGGGGGGGGAGAGAGAGAGAAAAAAAAATTTTTTCTCCT + !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!;8777==----61511EAAE,=>=>>>@AE@====>AAEAEAAAAAAABA83:*3.1=>>:?>8;>?AB@?8;;??8@599,BB<A@@DB?=???><C>?@><ACAAAA??D?B7887736?A???A?@<<=>AEEAAAAAAAAAAB826-8739:694?@F@ABBAAB???BEABABAABAD?@?BAA?AA?=?988:8?;;?>@?A865.;63797564889C@?>C5;BBA?AAA????A??@?A=@@@@ABCAA:====?D@?@AB????B?AAAABAAAAAAA?C??D@B>D<;804*5178:9@245188548AED@>?A8@?:@A@>?D???A@BB=<<<@;A<=?<:A?@@@?AB@@G??;9:1::9=:86/6?4792;;;EAAAAAAAAA?AAAEABAAAABBDAC1;1)62.72>??@82183*4+02)3737?;=D?=8+-7-5-162730;98:;2::/8:.*+(('+342.5.3;???A@@;8983545:;;?AA@;6/78;=;=>C0/,9/3++*)(40-<<>AA??D@@@@?ACA@BBC@A7:267.4,*35*+..3153,*(+-5+/),,,5.*)),,,40,+)*,,)**20-,,.+**)***-88-+2-+.-2<=32-*+)3-:.3+,/0)*,,-(,..*/.*)(/,..0/3/7/142+)))).,/582,*)()))-))//,))))++3)))))*1.0*')&+'+%''*22+)(((()+38,,))*)(()))((+()).()+*,&)*(&)&&),1)++/0,6.+,(&%,.5:15,*())(()+(+))))*,,),+,0325-'.12.,**,+,04,*&*+**-5@D1.*)+++.*)(,+)),''+''),-0-./946?<>>,))*,))+)0))()()),)),.5+,./,,4+.((''/,...()(,),((11592(.,)'))(,,*+11,**,,-)*+,1==A2/+5.-0;;:11*())','+.3/78;>??</*...1+*+(()( @U13a03e10.p2 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGCAAATTCAGAATTTCAAACGGCATTTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAGCTAAGCTGACGGAAGAGGGAAAGTGTGTGATAAATACATGTGCAGCTTTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCTGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAATGGTGATCACAGGATAGGTGTTTTTGTCAGGAGAGCCATCCAGACTTGCGAAGAACTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTTGGCATTGAAAGAGAAATGGAAATCCCTTGACATTTGCTATCTCCTCCTCCTCCTCCTCTCTGAAACAGCTGCCTCAGCTTCAGGCTCAACTTCTACTTAAAGAAGTTTTGAGTTTTTTCAGTTGTCGTGGACTCCCAGGTGGAAAGTCATAACCTTAGTATGCCCAGATGAACCAGGTGTTTAACTGCAGCGGGAACCTAAGCGCTCGCTCTGACCGAGGATCAGGGAATGATTTAGGAACAGATACCCCATGATGGGATCCAGGATCCAATCAGATTGAACTTGCCTGTCACCCTATGCTGATAAAACCCAACCCCAAACCCCAGGTCAGGGAGATGGATTCCAAAAAAGGTTTCCTTTTCTCAAAGGGCTGGTGCCATAAATATTGGGCCAGTGGTCCAACACTGGGCCAGTGAAGCCGACTGGATTACCTTTGATAAACGATTTAACCCCCGGAAAGGGCCTTAAATTTCCCCCCGTTTTTTGAAAATGGGGAAATTTTTTTAATGAAAATTTCTCAAAACCCCCTTGGAGGTTTTTGTTTAAAGCCCGTTTAAAAAAAAATTTCTCCTTGGTTAAAATAAAAGGAAGGGTTCTCTCCCGGGGGGAAAAT + !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!>9;8:533752?C544;4148449@7<@@@;=866686AB@=====@==E==;;;@=>===B==@::;;:7ABB99?A??<AAA>==;==?????AB??????AA??AAA==A========AA?B???@??A??ADCA@EE@@AAAAA======@??D@???BD?AAAAAA@=?C>:=?AAAAA??A===B???????D?@==<<@?AA?A???AC@BBAECAAA@@@C@@G@A@B<?A???AAAEE@@@BACA@@AACAFE=?7337AAAAEBA@?DD@AAACC?CD@ACAA@C@AABAABAAA=:===A<???A??AAA?AAA???AAAAAAC@@B@CAAAAABAA??BDA;7;?A?AACAABA@@CAAA?AA???<?87*.*29AAAAAAAABBBA@@?AAAAA?A==;BB??@?ABA??????@@>@@B?????@AA@AC?=<52*/38@A??>B=====8=>A=B======AB=8=;>==>==C=>=A=B=>=BA??A??DAAAA??===B=9EEAA?=;<538A??<773766C?@@EEBA?A>=6;/3=?4;8689C<79251:378=9:8:@BEAAA?AA=:5*,85=89..43:5:G@AAAABA>====>=>=====E=?AA??>3;:8=8=D?=?=?E;17?=?@=73/3/268B=B844*+()*))49BB==:3.,*1,**,**,-*2,/2,3*,5./;;8==>56.2@6A===7681/.33*+-66632,(,*).**.31,)(&))*)**()*00.56.4.1/1/6C85526575,,0,,41-+((.8882//35BB2/,+,*)'+*/54)(0)+,**&).))&),*'%''))***)*.*(/,))1*)))%(%'')(,-,**),0,3,+*,*)%,/3&&&)844..+))'$))*****050/++*+)**%+***))**+*(+..**))+')()& @U13a03e10.t1 CCTTGCATGCCTTGCAGGTCAACTCTAGAGGACCCCTGCAAATTCAGAATTTCAAACGGCATTTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAGCTAAGCTGACGGAAGAGGGAAAGTGTGTGATAAATACATGTGCAGCTTTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCTGCAAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCAAACTGCTATGCAAAAGTTATGATGGTTAATGGTGATCACAGGATAGGTGTTTTTGTCAGGAGAGCCATCCAGACTTGCGAAGAACTGTTTTTTGATTACAGATACAGCCAGGCTGATGCCCTGAAGTATGTTGGCATTGAAAGAGAAATGGAAATCCCTTGACATTTGCTATCTCCTCCTCCTCCTCCTCTCTGAAACAGCTGCCTCAGCTTCAGGCTCAACTTCTACTTAAAGAAGTTTTGAGTTTTTTCAGTTGTCGTGGACTCCCAGGTGGAAAGTCATAACCTTAGTATGCCCAGATGAACCAGGTGTTTAACTGCAGCGGGAACCTAAGCGCTCGCTCTGACCGAGGATCAGGGAATGATTTAGGAACAGATACCCCATGATGGGATCCAGGATCCAATCAGATTGAACTTGCCTGTCACCCTATGCTGATAAAACCCCAACCCCAAACCCCCAGGTGCAGGGGAGAAGGGATTCCAAAAAAAAGGGTTTCCCTTTTTCCTCCAAAAGGCCTGGGTGCCCATAAATTATTTGGGCCAAGTTGTTCCCACCACTTGGGGCCCGTTGGAACCCCGAACCTGAATTTAACTTTGAATTAAACGCAATTTTAACCCCCCCCCAAGAGACACCTT + (')*14.-*0-0**1,).0.%-.1:9479)7)'11>AAA=A>A>=912-/5:?A@DBA;;;@@@AAAA??ADAAEDBAAAAAABA@???@==40-:16:=???@?>9?C?;;C8?55-1.*1198<AA@F?;4686=?AAABA9;79;>DBABD@@A@C@AA=B=<><C8<=@;=@@@A@A??=C56>CC?CC?@A>87=;/<?A????A?AAA@@@A@@ABBAAA???@?AEAAAACC????BBB???AB@@D@>>?BC?@@F@@?==:;769?B69<570266=CBC==;;><?78-688@A??A<<942?:=;@85:49??DBAC@???D;A======ABA@?>?>6::=A<?DBB??;:;:;????<?CAAAA?C<;4;96====?AAACDCA@@AAAAAAAAA????BAAABAAAAAAAAAAAAAA==9===AAAAAAAAAAA@A88678B@AAAAAAAAAAA@A8==5;;?EAC9B=A?@@@B???=;;;?::===??8:2768=<@?9@?<??B???@G@@AAAAC@@;;;,2--81576A?>??A?A@A>=11/000210<=@@>5;75:ABB@@AA=7/6361,188@=====>8728709418823=5>1:-04128=:;;537753?<@?<4.8988;9;==<??@=;5;;@B==:=====9=757226.-7?C;/,///:?E;:)/.)((,()2/,,,',-/304)-337;?E=6242/72/5*,21,(((,,.243,)3-),1,))*/+)()+)*334:8/3')))*5,-+/5*+0)**,1**//2+1,(,,/-(,*-,1.,-,)))*.,,47/,0*+.))-**>+'*').,4371-*+22**-*-1))*)(+'&+*+& @U13a03g02.t1 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTTGCAAAGTACTATAAGAATAATTTATAGCAATGAGTTTAAAACTCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCAATAATGCAGTATGGTATATTTTTCAACTTTGAATAAAGAATACTTGAAATTGAAAAAAAAAATTGAGTCTGATGGGTCTAGTGTGTTTATAAAATGACTTAAGATCCCACAGTTATTTTAAAGTAATACATTACTCAACTGGTATTCATTTTGATGCCATTATTTTATTTTATAAAACTAGTCATCCTTGCAGAAGTGTATCTGATTAACTCTTGACAACTACTTTGCCTATTTTATTAACAGCTGCATTTAACCCACGTGACAGGATAACTAATTTCTATTGTTTTTGTATTTTTGCCTCCTCCTTCCAAGATAGCAGTAGAGTACTGTGTTAAATCTTGCTTCAGAAGAGCTTGTTTAAAATAGTTATAAAGAAAGTAAAATACATAGAAAAACACGTTATAATTTTAAATTAAAAAAGAAAAAAGATGTCTACTCTGAATAAATTATGCATACATATAAGGTCTGAACAAAAACATGAAAAGATGGGCTCTGAGTATCAATTTTAAAAATCTTTACCAGTATAACATTACTCAAACAAAAATTAAAATTTAATATAATTTAAGTACATATTCCAAGACAACCAATGGAACCTTGACTGTTAATTCTGGGAAAAGATCCC + !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!DEEEAA=2?777;42;/73E;;=@=@@?@AA>==>=;?BB@@@AA?ABAAABAAAA@AEABAB?A==?@AEEBAAAAADBECCA========?7=3==AABDEEEEDADFA????DB?AAAAAAAE@=@==@@@@=BB==:@@>E?A?AAA?@@A=AAEFBEFE@?==@>;AA???;B==??A?A????AFCABCCDC?A?DAA@????DAA@DAAAAABABEEAAAABAAAA@@CD@BC@ED@A?>?@CBA?B=>>:@EEAAAACAAAAAABBAAABACD?AAA?????@A???8:=5:6;A@DA?AAAECAAA==>=:9ADABC@@==>>DAAAAABABAEEEAAAAABEDA?A:@=<@>A?===8==?ACEAAAAAABAA<<??<?>>;;;ABAAAABA>@@AAAAEEE?AA;=>EAAAD?8A39:<==?????CCDAAB@@=:<=>880424?DADEBAAAEEEEBAABA??AAA?;?9??>@==8@ABBA=AA?@9:C;C;AA@DABCC@ADBEAAABAABBA@=B;;>????;=8<>>=@=AAAA@A><0.2-*30:82/)/,'*11=::A=@;42+99BD56-./(/+-BD@@=:==842?3/*,39=A??<<6.8)053;9AAAA??B?:611-*211*,3-0**.03;A4..56@B;:60.).)+)-.42,*(,*0)*&*1--1+-72054-+02?8:-,0.+,9(+22..'(,10 @U13a04c06.t1 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXATTTTAAACAACCTCTTCTGAAGCAAGATTTAACACAGTACTCTACTGCTATCTTGGAAGGAGGAGGCAAAAATACAAAAACAATAGAAATTAGTTATCCTGTCACGTGGGTTAAATGCAGCTGTTAATAAAATAGGCAAAGTAGTTGTCAAGAGTTAATCAGATACACTTCTGCAAGGATGACTAGTTTTATAAAATAAAATAATGGCATCAAAATGAATACCAGTTGAGTAATGTATTACTTTAAAATAACTGTGGGATCTTAAGTCATTTAATAAACACACTAGACCCATCAGACTCAATTTTTTTTTTCAATTTCAAGTATTCTTTATTCAAAGTTGAAAAATATACCATACTGCATTATTGCAAAAATTCACTGGTACAAAACACTTTGCAGCTGGTGAGAAGGCCATAAAAAGTTGAGTTTTAAACTCATTGCTATAAATTATTCTTATAGTACTTTGCAAATTCAGAATTTCAAACGGCATTTTCTTTTTCTAAATTGCCCACAGTACTCGAGGTTCCTGAAGCTAAGCTGACGGAAGAGGGAAAGTGTGTGATAAATGCATGTGCAGCTTTCTGTTCAACTTGAACAATGATTTTGTGGTGGATGCAACCTGCAGGGTAACAAAATTCGTTTTGCAAATCATTCGGTAAATCCCAACTGCTATGCAAAATTTATGATGGTTAATGGTGATCACAGGATAGGTGTTTTTGTCAGGAGAACCCCCCCAGAATTGCGAAAGAAACTGTTTTTTTTGAATTACCGAATACCAGCCCAGGGCCGAATGCCCATGAAAATTATGTTTGGGCCTTTGAAAAAGAAAAAAATGGGGAAAATCCCCTTTGGACCATTTT + !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!@@=B@:6;2@=,?647<>>ADB??:0,1..53392=A2711?AAABAAAAAAAAAB==;667.88,367;=9===867:AAB=A52)..0;;?@CC@???>AAC>@9@;;9>4:>@=8??@;?>>9>@BA??;;;9@;AD@8;5,75<@9/2*777<>A<4,*736AAAB=;;9;86:4:7187ABCDD?=?/*8;AAA:=:@859:?>AAA=B??@@@@@A@??49:5;=C<@=?????>???AAAAD=9>?;;?@==;;6586@8@???34+---58>@@B?:7-837::3+/29;;?C:9.977??7:;;?@>@@AAB?@??>?AA@B684-8@@@?@DAAA>>,*0;?>AB>B>A>A??86@@@B?@=???CGAAC@@@@EBB75;;=;:8415138=?D=78,/.*32:B>>@?;8888C@@@@@A????<6;>9;C=@?87:9:?ADD;74;<AAAAA@@>AB?>@EBBB@A@AAA@;CA=C?7;578?@@@@=@@@@A:;4+486<7/--/2/.5/49?AAA;>7)99?>::7/41./1.75C?<AAAA@@A=8>=0.)*-9BBAAADE@AAAAAA?????9;;;2;8==:<6=A?==:C<677=;==DA?1./*.1=:,024*,/285CCAA@@65543-)(/-/4=7/,).1)/,,-2)(.().+48./1**031;8==?<=002-*-./.71.976/.;;;BAB?<7-()(+,)+)+.+()12:*0*(2+,*-0156522/111;5;;=7//,)*(,*,/-+*+1'+09<0),)*()1-(('(,'++10.+61/3--+)+/./,*-*.376588773?:88*-11::515,20,,-+*(()(-+33A< @U13a05b10.t1 ACTTCCCTTGCCGCTGCAGGTCGACCTAACAGGATCCCTGGCTGTATCTGTAATCAAAAAACAGTTCTTCGCAAGTCTGGATGGCTCTCCTGACAAAAACACCTATCCTGTGATCACCATTAACCATCATAACTTTTGCATAGCAGTTTGGATTTACCGAATGATTTGCAAAACGAATTTTGTTACCCTTGCAGGTTGCATCCACCACAAAATCATTGTTCAAGTTGAACAGAAAGCTGCACATGTATTTATCACACACTTTCCCTCTTCCGTCAGCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAGAAAAAGAAAATGCCGTTTGAAATTCTGAATTTGCAAAGTACTATAAGAATAATTTATAGGCAAGGAGTTTAAAACTCAACTTTTTATTGCCTTCTCACCCGCTGCAAAGTGTTTTGTACCACTGGAATTTTTGCAATAATGCAGTATGGTATATTTTTCAACTTTGGAGCTAAAGAATACTTGAAACTGAAAAAGAAAAATTGAGTCGGATGGGTCTAGTGTGTTTATAACAATGACTTAAGATCCCACAGTTATTTTAAAGTAATACATTACACCACTGGTATTCATTTTGATGCCATTTTTTTATTTTAAAAAACTAGTCATCCTTGCAGAAGTGTATCTGATTAACTCTTGACAACTACTTTGCCATATTTTATTACCAGCTGCATTTCCCCCCGTGACAGGATAACTAATTTCTATTGTTTTTGTATTTTTGCCGCCACCTTCCAAGATAGCCCTAGGAGTACTGTGTGAAATCCTTGCATCAGAAAGACCTGCTTTAAAATAGTCATAAAGAAAGTAAGAATACATTCAAAAACTCCTTT + (+/+*&)))+)))+)+10/79:*-))*.*(.,.***-6====A=>@E==A=>87;:BC<863)*;:A@?=7=CA??:746;BC?????;@=>=A>A993578@@=A?AAA==::=A=@@==?B=>=AAEAAAAB@>?AA?@FAC@BD?;;;??=@@===D==::4-6,25<=8;2<79@@B?;6;>==?984106<>??=0.+*/-/67AB@;5*.37:9==@?=.00*3.5;;;?@@;>4:==????CA;;.,,*-<2,+2,.2245===?A?9=?;>A6>6/669==B=?=<6853*708;873>39?.*)(1-2==:A9=:=?A@@=9<@@<9????>@@AA?;@5<?9@7:9=::305.32.2.95;?A;5-))2,*729**608??23???CAC98+.8;>A?@@@-2*)23.664<AAA?:2.>>C@:44.00465=<12;>56;4*+,3/*C;8@A???>><=CBA:8://011.)(,(*<1823...167,,)(21=286777551137943,))2.2-0>??+/;16;;GAA=1-.,+.:<6964626497?7:0084;9AC?AAAAA;;85>-53-1+77?:?;@C;???@7898;;=6::***,)*0/5+.463/.6774,1-8:?@AA=@;A-*4.84.37.,0).1(1;9@</-*,.)**,/5*-663-3-042,,23-,,.024,2::20/,-38/1/34355-1+).++)*//-*2-2+2,-46:>;:,(1**314,+,+)25,*))-+*/--**((+(0//*---*(*++)01--1*,(()(),-?311'+.))'(()17:6-++(+*%,19-(**)*-&'+*..(+**((,*,0))+)()0/ @U13a06d03.t1 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTTTAAGTAGAAGTTGAGCCTGAAGCTGAGGCAGCTGTTTCAGAGAGGAGGAGGAGGAGGAGATAGCAAATGTCAAGGGATTTCCATTTCTCTTTCAATGCCAACATACTTCAGGGCATCAGCCTGGCTGTATCTGTAATCAAAAAACAGTTCTTCGCAAGTCTGGATGGCTCTCCTGACAAAAACACCTATCCTATGATCACCATTAACCATCATAACTTTTGCATAGCATTTTGGATTTACCGAATGATTTGCAAAACGAATTTTGTTACCCTTGCAGGTTGCATCCACCACAAAATCATTGTTCAAGTTGAACAGAAAGCTGCACATGTATTTATCACACACTTTCCCTCTTCCGTCAGCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAGAAAATGCCGTTTGAAATTCTGAATTTGCAAAGTACTATAAGAATAATTTATAGCAATGAGTTTAAAACTCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCGTTAATGCAGTATGGTATATTTTTCACTTTGAATAAAGAATACTTGAAGTTGAAAAAAAAAATTGAGTCTGAAGGGTCTAGTGTGTTTATAAAATGACCTTAGGAACCCCCCGTTATTTTAAAGTTAGACCTTTACCTCCACTGGGTATTCCTTTTTGAAAGCCATTTATTTTATTTTTAAAAAAACCTAGTTTCTCCTTTGGCCGAAATGTTTTCTGAAATAAACCCTTTGAACCACTTTCTTTTGCCCTTTTTATTGTTAACCCGCCCGCCTTTTAACCCCACCGTTTAACACGGGAAACA + !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!@A???>??893;5.8;?B?C;=;====;88;=CAAA==961/9.5.5=7::>=8:=75:6/34-6;?A@??;<,6625777:5:4:C;?DAAAAAAAADAAACDB@@EAF@A>??EDBBFDGCAAAAF@DA@B?=AC?DAACCC@?@@AAEEEDAAA@@A;;>7==?=@==A=>==A?AAEB@??;???CC?32(*).66/8??AAABAC@EAAA=ACBAAB??AAA?97+799B@=?=A?@==B;=====?EA@@@?B@=B=A@A?A?AABAABB??A????BAA?B??=BB?::8:=9DD:=9:?5:838<@@?;??;AAACD?FACEA??AAACC@@CF?D?CA?CD?@A??;6??BBA>==6??A?B======>@<;4:=A:=====?<AA997+;????>???AAAAAA?6:=63*3?9>/86:??B?8??>?9A>=B16;9:=?>DA?D@A?C<6<=C==AAAAAA?BB89448=C=AAABD@?A???CAAAC@95778;?CABCA6.5--2+*3,495;></93**.567?;++9-,0//23==DB33.+4.66553?=>==51+*.()+.+,57;?AAAA@AA@@8/1((21/32,*51345514*)(21./3/00+/,-))),-*,0))11:87?6941355)),'*)))'*,(*()-*),)+-*,+)((+,+1.::42+.-(+.,6*-+(*+53-.3.,.(*(+)6.+)**,**)(,,2*+5+(*)).*'0**1+*(*,+-2-01/)*)))-+)))(),()*,).,2)+,.03.+)$')'-2*..-)*+)()-+0056))*-6+))))))))/..(++*-))&& @U13a08b04.t1 CCTCGATCTAGAGGACCCTCTCCTGACAAAAACACCTATCCTGTGATCACCATTAACCAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX + (),**+(,/+*.**'&**;;B===6:4/A4266385;===@AB453355==B?7476<;!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! @U13a08f10.p2 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTTAACAAATCATCAGTGGTTTAGAAATTTCATAAAATTTCTCATTTCAAAAACGAGAAAATTAAGGCCTTGCGGGGTTAAATCGTTATCAAGTAATCAGTCGGCTCACTGCCCAGTGTGGACACTGGCCAATATTATGGCACCAGCCTTTGAGAAAAGGAAACCTTTTTTTGAATCCATCTCCCTGACCTGGGGTTTGGGTTGGGTTTTATCAGCATAGGGTGACAGGCAAGTTCAATCTGATTGGATCCTGGATCCCATCATGGGGTATCTGTTCCTAAATCATTCCCTGATCCTCGGTCAGAGCGAGCGCTTAGGTTCCCGCTGCAGTTAAACACCTGGTTCATCTGGGCATACTAAGGTTATGACTTTCCACCTGGGAGTCCACGACAACTGAAAAAACTCAAAACTTCTTTAAGTAGAAGTTGAGCCTGAAGCTGAGGCAGCTGTTTCAGAGAGGAGGAGGAGGAGGAGATAGCAAATGTCAAGGGATTTCCATTTCTCTTTCAATGCCAACATACTTCAGGGCATCAGCCTGGCTGTATCTGTAATCAAAAAACAGTTCTTCGCAAGTCTGGATGGCTCTCCTGACAAAAACACCTATCCTGTGATCACCATTAACCATCATAACTTTTGCATAGCAGTTTGGATTTACCGAATGATTTGCAAAACGAATTTTGTTACCCTTGCAGGTTGCATCCACCACAAAATCATTGTTCAAGTTGAACAGAAAGCTGCACATGTATTTATCACACACTTTCCCTCTTCCGTCAGTTTAGCTTCAGGAACCCCGAGTACTGTGGGAATTTAGAAAAGAAAATGCCGTTTGAAATTCTGAATTTGCAAAGTACTATTGAGATTATTTATCGCAATGAGTTTAAAACCCACT + !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?;=;F@844AA4=@7AAAAAAAA@??@??B?<GA==4239==@@=:@:9;22;96:525:;896:;;;;??B;;AD??AAA?B???AAA??AA==>=?==@====?===>=??AAAAA?B;54/14=BACABBABA====@:=?<A=:CCABAA@@@@D??@@??ABBAAAA?A????AAAAAAAAAA??ECACB@@GGEC@EEAAAA?A?:=>===AAAA?BAAA?AAA@======??>AAAB@8::==>F?>?DA?AAAAABBB???ACDFA@BAABB@>@>@DEEA@@?????AAAAAB<@;9=@A===;=AA=5====AAAAAAAAA???=@=>>?=;=???A?====??@C@>@@AAAAAAA??AA@====<C@A==8?==AAEA@D>@AG??:<61<<?>@@@@@@@AAAAAAAAAAAA?645/.5A=::87;?AB:=;::<AB??BBFBBBAABBEABFBBCG@@@A==BC;>D@?>??@8B?;331747?A=;==>E====@;A??E@?==8@=;;BA=>;=:9==44==;=??AA<:=9<6:???AAA;;841581/78;6;166:9?E?>@==9;98;9;=;92:/88====>==>?A:0575:;=====:EAA======AABAB62199==98===;544/6;6=4/3**35;5:;A9/()**0;0**,,-2;:?;;7-,+*-(,,,3555.*+-63;0+.,*(,+6892/.)*/),15?9-+))17=====@810(),-64-0/..**13*&(*,)(%)*--;3713-4.+(()),.,+/-+,*,,/389-'*)*(,)2A04,1./+,*/+)+)&&*.*)+)(()0/21**-.)((($(%)((++**+*-//(*())(((0(*(.*'%**))-++' @U13a08f11.t1 GGGAGTGCACTCGATCTAGAGGACCCTATTTATCACACACTTTCCCTCTTCCGTCAGCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAGAAAAAGAAAATGCCGTTTGAAATTCTGAATTTGCAAAGTACTATAAGAATAATTTATAGCAAGGAGTTTAAAACTCAACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCAATTAATGCAGGTATGGTTATATTTTTTCAACCTTTGAATCAAAGGAATACTTTGCAAATCTGGAAACAATAACTATACTTTAAGTCTGAAACTCTGTTCCTGGATGTCGTTTTAATAAAAATATGGACCTTCAACGAATCCCCCACATAGCTTTAATTTTTAAGAAGTTTAAGATACAACATCTTCGACCTTCAAAACTGGGTTAGATATCTCTATTCTTTGGATGGCCCACTTATATTGTCTCTCAGATCTTCTTCTATTACATAACTAATAGCGTCCGGTTCTCACTCTCTCTCTCGACCAGCGAAGGTATGCTGTGCCCTGGAATTGAATACCTCCTTTCGGAACACTACACTGCTACTTTATGGCCCTTATACTTATATAATCTTATATCACTATGAGCCTGGCCATATCTTACACCGCGCGCAGACGGTTGAGAACAGACGATAAGACCACTACACATCTATTCTCATAGATTTGTTTCTATCTGAGTATGATATCTTCTCTGAGCCTCTCCACTCTCCCTTCTCCGAATGAGGCAATATAGCGCACGATGCTCAGAGAAGCGTAGTCGCGTGGTTGGTTTCTCGATAGATCCTCTTCGCCCTCTCTCATGACAAAAGCGAAGCACTCTTGTTCTCTGAACGAGAGTCTAGCTGTCTTTACCAGAGACGGAAATGAGTTGTACTAAATTATACTCTACTCTCGTCCATAAGCATCAGCCGCGCCGTCTCTTATCGCACATCTCTGCTCTCTCAATAGCTATCGTGCATGTATACACAGAGAATAGATCATGCATGTACTCGTATATACGTTATGTCATCACTCTCTCTGCGTAACACATGACGATATCTGCTGATCTGCGCGATCATCTCTCTATTCATATATCATGATAGGGTCGTCTGTGAACACATCACATACTCATCTTATCGCGAGAA + ''$&'&-&((,/,')68;=2.+&(*.1=:9==9:@@?A?9::=::=BAA???AAAA@@=>==AAC?=>:489/-1(22/===BAAG@????<7;397498/730????A=D??@;<@?>=A8?884/37>@AAC=A::2.2.744??:>;982:A8)'03/97=@?<@@?@A@B@@?::>:;;@=B;95;76886==@C=:?8?:A;5;:7/,/-*20233623-<:6*))*)),,*-*+74596.2//5/.*7:32,/,/2/<,+*)*+/-*2/,-2*-2+--**)+**,-,*++++)()+)())))(,,()(((,,)*),))+)&()))*+'+())&**,3//5+)*((+)*())'((++%()2+:@/-,***(.*,+./)**,.6-))*+***./*,**-1&**((*())+)(,+)*+)*-*+*+/,-.((()(512,)),.,+,*(*+*+/5),'')'0+)()((((..3))*'(()*-,*0(+/+(*))*(()))-))*,'((*,/*))')))*++,*,*()(,(()+((+*,,**)*),&()*.,--3+(+,))(*(+/(,,)*()())((,)+.,)),'''1)+*(*)*0/.-*)+),)(('//(*-+1..*0*.-.+/-4+*))))*/.)+++*),,)))+))+('+))))(()*)))-+4''))''()))))-/0.0+.81/*+*,*+)+,)/,1,,*/,))+,***-)))))+)()))))-0,,+)))('-)*(*++)-62,*)))()++))+-')**.,./)+*()+)))))))()***11.1))''+()+)1)),,))*,,,)*15.*+1***+)+)).&****,,.3*/.-+)),/-**))),)))(+**))+),0*)(($*)()))%.+*+/*)*,+*&)')*0()+()+*)-)(()))))'()'''(()2/,.))-/+-,1+(-'+'')+)))(()),,*)))).)/--)()(-+)()))*,+3-0..-*+()*.++')++')')))%**.6456**,*+))(,(..713+0*,.1))(,)+*)(1())))*,.)*0,)++,+/76,,,,))-)+)+,),(),***,)(*.,,.:,+*+1(((,,)**%,*,)))+*)*5/:/0+(((&))&()))())+*)))(***.02*,())),()*(++*+)))(' @U13e07d02.t2 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXATTTTATACTTTTAGGCACTACTGGTCAAAGTATTTGGGATCTTTTCCAGAATTAACAGTCAAGGTCCATTTGTTGTCTTGGAATATGTACTTAATTATATTAAATTTTAATTTTTGTTTGAGTAATGTTATACTGGTAAAGATTTTTAAAATTGATACTCAGAGCCCATCTTTTCATGTTTTTGTTCAGACCTTATATGTATGCATAATTTATTCAGAGTAGACATCTTTTTTCTTTTTTAATTTAAAATTATAACGTGTTTTTCTATGTATTTTACTTTCTTTATAACTATTTTAAACAAGCTCTTCTGAAGCAAGATTTAACACAGTACTCTACTGCTATCTTGGAAGGAGGAGGCAAAAATACAAAAACAATAGAAATTAGTTATCCTGTCACGTGGGTTAAATGCAGCTGTTAATAAAATAGGCAAAGTAGTTGTCAAGAGTTAATCAGATACACTTCTGCAAGGATGACTAGTTTTATAAAATAAAATAATGGCATCAAAATGAATACCAGTTGAGTAATGTATTACTTTAAAATAACTGTGGGATCTTAAGTCATTTTATAAACACACTAGACCCATCAGACTCAATTTTTTTTTTCAATTTCAAGTATTCTTTATTCCAAGTTGAAAAATATCCATACTGCATTATTGCAAAAATTCACTGGTACAAAACACTTTGCAGCCGGGTGAGAAGGCCATAAAAAATTGAGTGTTTAAACTCATTGCTATAAATTATTCTTATAGTTCTCTTGCCAATTTCGAAATTTCAAACGGGCCTTTTCTTTTTTCTAAATTGCCCACCGTTTCCCGAAGGTTCCTGAAACCAAACTGAACGGAAGAAGGGAAAGTGTGTGAATAACTC + !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!=9=;49.-,,66,2(*18=56--1A;CEC?4787<?A;;;A:=BBAA=@@992;A>@D?EAEB894+75??BD?AAAAA??@=B=@?A??B???ABBEAAAABA@@@?CCFBBBAC@A>???>;AA@ACA?;8817AA?=;8;58?DDBAAAC???>CC93.*9.8CAAABAEDA@>D????A@??5:94>?:@BAA=??A?CDA@CCAB@AADC??97176/6;1?ADABAAAAAADAAAAEAAAAAAAAAAAAD??@??@DDAAA??8===?AAAAAAAADAAABABBBCAADAADDFAD@?CADDD?=A<5;2686==AAAC@AA@DDFCAFD??;;:8AA=>@:=9:==>>=88:+363?=;?@@EDFAAAAA?AA?AA??AAA===C?;<?@??=844.97?A@?:9A97B;;=>>AD9::646+6>2>806669>@??;8@???@=<<;@;E@D@AABAD>=>>=@===AAAEFFAAAAAAA??59?=@?20)),.7<@DC>==9=>A@;6532748?@@;<5<==A;==8==61**0-12173>@<@=A@2935<EBAA??AA??B>81..2988:61*25:<B@CCAADDEAAA??B?AA61-+34/836ADAA@98/8:55-397BD:1+,.2,.**/+--0?<8-,2*-24=;;5?>/5+,*24.,.+(+))*(-*(,))-)(-*(9,,,,(*.6@AA>-/-/((),+23;67>61)()(*()****,5:>A8;-,-*())))+))),,-,*+*,%15*43,+)))*(-3+,,65,*++,/-+((+,.36-4,+)+((0,())+&3*.)*++**)/4(5/(3..*)-/0453315702**-*14*-+/+(+.*((++ @U13e07f02.t2 ACATGCTGCAGTCGATCTAGAGGATCCCATGTCAAGGGATTTCCATTTCTCTTTCAATGCCAACATACTTCAGGGCATCAGCCTGGCTGTATCTGTAATCAAAAAACAGTTCTTCGCAAGTCTGGATGGCTCTCCTGACAAAAACACCTATCCTGTGATCACCATTAACCATCATAACTTTTGCATAGCAGTTTGGATTTACCGAATGATTTGCAAAACGAATTTTGTTACCCTTGCAGGTTGCATCCACCACAAAATCATTGTTCAAGTTGAACAGAAAGCTGCACATGTATTTATCACACACTTTCCCTCTTCCGTCAGCTTAGCTTCAGGAACCTCGAGTACTGTGGGCAATTTAAAAAAAGAAAATGCCGTTTGAAATTCTGAATTTGCAAAGTACTATAAGAATAATTTATAGCAATGAGTTTAAAACTCGACTTTTTATTGCCTTCTCACCAGCTGCAAAGTGTTTTGTACCAGTGAATTTTTGCAACAATGCAGTATGGTTTATTTTTCAACTTTGAATAAAGAATACTTGTAAATTGAAAAAAAAAATTGGAGTTCTGGATGGGTCTACGTGGTGTTTATAAAATAACCTAACGCATCGCCCCATCCAGCTTTTTTTCTGAGAGAGTACAGATACCAGCCACTCCCGCGGGGTTGTTTCGATCTTGCAATGCCCCGCCAACTTTTTAATTTTTAGCAGAAAACCCCAGGTTCTAGCTCCCATTGACCAGAAAAATTGTTTATCCTCGGAAATACAAACGCCCTGTTGGAACCACAACTCATGCCTCTCTGCGCCCCTCAAGTTCGTGTAAATGTGAAAACCAGCGCCCCGCCCCGAGTTTTAGAAACGCCCGCCCCGCCTTGTGGAAGCCTTAGGGGAAGTATAACGCCCAGCGACGTTCTGCTCTCCTGGACAGCGTCGGCGTATGGTATCTGACGGTCTAAACATACGTCACGTAACGGGAGCCCCCCTCTTCCGCATCTCTCCCCACTATTTGTGGCTAGCAGAAGAGAAATAATAAGCCGCAGCGTATCTGATGAGGAGCAGACGTTATCACGCTCTGCGGTGGCGGTCTTTAGAACACAAAATTTCGCTGTTGTCGCGCCCTTCTCCGACGGAAAAGAGAAAAAACCCTCTCTGTCTTTTCTATTAAAATAAGTAATTGGTGGGTTTTTTCTGCTGCCTTCTGACGACGACCGAAGAGAAACGCGGGTTTTGTATAACGCAGATATCACATCGCGCGCCCTCCGCGTCCG + *'-,,*55(,++/)''..912.-')).3ABAABAA=02-633===ABBAAA?A?A@AECAAAABADAA<>225*5/.6=?AADDAAAAABB???C?AAAAAEE?AA?A@AAAA??=@;:;77:9=B=>AABCA??B??A?AAAAAAAAAACCA=8<;C==@@@@A?AA?A?AAAAADAAAAADA::>67:5A==????=?9965?>9>?>>ADAAAB39*776??DC?<<?A<??88;69;>;A59A@?@@AAAAA@A?=AC@AC@8A18094130.9525;7;>;=77>>5;@@?=A8:?@>>==A;??>>?@@A<;<7;9-*1(//,0577;231.,+828=92;;@@;?@?A84:197138.705AA@@A@@88889....02;?@>=:?@99>A@@AD=6:6=7395577A;=B84*-)2/8FB@@@<13.*/8=@@??;98181215<<;:=9/.***(++*+),*/2571-65*7/8944/3,0*&+)),28;2*0*.000*/,.7>=>5.1.1389B83;.3.2,(2-())&,)01/.318=84-,**((+)/)22-**,.*+2-+(()(,,**.2659.+-+),,%-)))*())(((,,,)(,,+**)(()*(**)+%*()&*'')'')+)))(+**))')(),*)&+%)-,*-)**,.))**+,,*-.*)-,,)(((()(()*-++*)*-**,)*((((),-,))(()('))((())**)*)+)*+*,.22-),+*++*++**,)*..2-)(+***+&('(+&((()+**,*,)***))())))+,(,.((,*-.***(*)((''('('(*(*)))*,*(%$)(()((().3+(((*-**'%)))+++)+*,*)*+--**)*,(*,&&)%%+-1,+*-)+*''('(')*))()+)++))'())))))*)))*-,*,,)))))(*)(((-)***+,*)(*+-*)&()''*.).('&)'*)-))()++30*+**%***(,))),))-,0))(++***((())*1,-64/2,./.-/()).*)))))(('')++).++,))--))-)6'(''''(-,//,/)%)((+((''***()/*())*+*0'+)*+**),*))+'((&(+**,-+*)+-:;.,*,**)+()'+2-192-*+(+(*$$+$)'))0+,*,2*)-).+'+''*)(+*,))*&*++')(++(+(()+))($(&(*+().'*+)))+)'-))+)&*))))**))*)()*+)*,+))))'+)+/12,)(')+$'*()(*