Mercurial > repos > proteore > proteore_clusterprofiler
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author | proteore |
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date | Fri, 09 Apr 2021 14:39:05 +0000 |
parents | d951677a50d4 |
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Wrapper for clusterProfiler Tool ================================ **Authors** clusterProfiler R package reference : G Yu, LG Wang, Y Han, QY He. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS: A Journal of Integrative Biology 2012, 16(5):284-287. doi:[10.1089/omi.2011.0118](http://dx.doi.org/10.1089/omi.2011.0118) **Galaxy integration** T.P. Lien Nguyen, Florence Combes, Yves Vandenbrouck CEA, INSERM, CNRS, Grenoble-Alpes University, BIG Institute, FR Sandra Dérozier, Olivier Rué, Christophe Caron, Valentin Loux INRA, Paris-Saclay University, MAIAGE Unit, Migale Bioinformatics platform This work has been partially funded through the French National Agency for Research (ANR) IFB project. Contact support@proteore.org for any questions or concerns about the Galaxy implementation of this tool. -------------------------------- **Galaxy component based on R package clusterProfiler (see ref below)** This component allows to perform GO enrichment-analyses. Given a list of IDs, the tool either (i) performs gene classification based on GO distribution at a specific level, or (ii) calculates GO categories enrichment (over- or under-representation) for the IDs of the input list, compared to a background (whole organism or user-defined list). **Input required** This component works with Gene ids (e.g : 4151, 7412) or Uniprot accession number (e.g. P31946). You can copy/paste these identifiers or supply a tabular file (.csv, .tsv, .txt, .tab) where there are contained. **Output** Text (tables) and graphics representing the repartition and/or enrichment of GO categories. **Packages used** - bioconductor-org.hs.eg.db v3.5.0 - bioconductor-org.mm.eg.db v3.5.0 - bioconductor-org.rn.eg.db v3.5.0 - dose v3.2.0 - clusterpofiler v 3.4.4 **User manual / Documentation** of the clusterProfiler R package (functions and parameters): https://bioconductor.org/packages/3.7/bioc/vignettes/clusterProfiler/inst/doc/clusterProfiler.html (Very well explained)