#FILE	SEQUENCE	START	END	STRAND	GENE	COVERAGE	COVERAGE_MAP	GAPS	%COVERAGE	%IDENTITY	DATABASE	ACCESSION	PRODUCT	RESISTANCE
SAMN11840202	contig00001	43895	45142	+	mdtA	1-1248/1248	===============	0/0	100.00	98.00	card	U00096:2154016-2155264	MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC.	antibacterial_free_fatty_acids/aminoglycoside/diaminopyrimidine/carbapenem/aminocoumarin/phenicol/glycylcycline/monobactam/penam/fluoroquinolone/macrolide/acridine_dye/triclosan/tetracycline
SAMN11840202	contig00001	45142	48264	+	mdtB	1-3123/3123	===============	0/0	100.00	99.84	card	U00096:2155263-2158386	MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex.	aminocoumarin/aminoglycoside/diaminopyrimidine/carbapenem/antibacterial_free_fatty_acids/acridine_dye/tetracycline/triclosan/penam/fluoroquinolone/macrolide/phenicol/glycylcycline/monobactam
SAMN11840202	contig00001	48265	51342	+	mdtC	1-3078/3078	===============	0/0	100.00	99.84	card	U00096:2158386-2161464	MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.	diaminopyrimidine/carbapenem/aminoglycoside/antibacterial_free_fatty_acids/aminocoumarin/glycylcycline/monobactam/phenicol/acridine_dye/triclosan/tetracycline/macrolide/fluoroquinolone/penam
SAMN11840202	contig00001	52755	54158	+	baeS	1-1404/1404	===============	0/0	100.00	99.93	card	AP009048:2165013-2166417	BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity BaeS is not necessary for overexpressed BaeR to confer resistance.	aminocoumarin/carbapenem/diaminopyrimidine/aminoglycoside/antibacterial_free_fatty_acids/tetracycline/triclosan/acridine_dye/macrolide/fluoroquinolone/penam/monobactam/glycylcycline/phenicol
SAMN11840202	contig00001	54155	54877	+	baeR	1-723/723	===============	0/0	100.00	99.45	card	AP009048.1:2166413-2167136	BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes.	phenicol/monobactam/glycylcycline/tetracycline/triclosan/acridine_dye/penam/fluoroquinolone/macrolide/aminoglycoside/carbapenem/diaminopyrimidine/antibacterial_free_fatty_acids/aminocoumarin
SAMN11840202	contig00001	197758	199401	-	yojI	1-1644/1644	===============	0/0	100.00	97.51	card	U00096.3:2306972-2308616	YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules.  The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI.	peptide/nitroimidazole/rifamycin/pleuromutilin/penam/fluoroquinolone/cephalosporin/macrolide/tetracycline/acridine_dye
SAMN11840202	contig00001	257738	258706	+	pmrF	1-969/969	===============	0/0	100.00	100.00	card	U00096:2367071-2368040	PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.	peptide
SAMN11840202	contig00002	125167	126915	-	msbA	1-1749/1749	===============	0/0	100.00	100.00	card	U00096.3:966621-968370	MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A a major component of the bacterial outer cell membrane and is the only bacterial ABC transporter that is essential for cell viability.	peptide/rifamycin/pleuromutilin/nitroimidazole/tetracycline/acridine_dye/cephalosporin/macrolide/penam/fluoroquinolone
SAMN11840202	contig00002	208622	209854	-	Escherichia_coli_mdfA	1-1233/1233	===============	0/0	100.00	98.38	card	JQ394987:1-1234	Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter.	antibacterial_free_fatty_acids/bicyclomycin/diaminopyrimidine/isoniazid/lincosamide/benzalkonium_chloride/rifamycin/nitroimidazole/nucleoside/macrolide/penam/rhodamine/peptide/fosfomycin/glycylcycline/phenicol/cephalosporin/fluoroquinolone/tetracycline/acridine_dye/oxazolidinone
SAMN11840202	contig00003	180544	180902	+	Klebsiella_pneumoniae_KpnE	5-363/363	========/======	2/2	98.62	75.83	card	AP006725.1:2483890-2484253	KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime ceftriaxon colistin erythromycin rifampin tetracycline and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate deoxycholate dyes benzalkonium chloride chlorhexidine and triclosan	diaminopyrimidine/bicyclomycin/antibacterial_free_fatty_acids/benzalkonium_chloride/isoniazid/lincosamide/nucleoside/nitroimidazole/rifamycin/penam/macrolide/aminoglycoside/peptide/rhodamine/phenicol/glycylcycline/fosfomycin/oxazolidinone/acridine_dye/tetracycline/fluoroquinolone/cephalosporin
SAMN11840202	contig00003	180894	181218	+	Klebsiella_pneumoniae_KpnF	6-330/330	===============	0/0	98.48	75.39	card	AP006725.1:2484239-2484569	KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime ceftriaxon colistin erythromycin rifampin tetracycline and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate deoxycholate dyes benzalkonium chloride chlorhexidine and triclosan.	fosfomycin/glycylcycline/phenicol/cephalosporin/fluoroquinolone/acridine_dye/oxazolidinone/tetracycline/aminoglycoside/rhodamine/peptide/rifamycin/nitroimidazole/nucleoside/macrolide/penam/bicyclomycin/antibacterial_free_fatty_acids/diaminopyrimidine/isoniazid/lincosamide/benzalkonium_chloride
SAMN11840202	contig00003	213611	213994	-	marA	1-384/384	===============	0/0	100.00	100.00	card	AP009048.1:1621288-1621672	In the presence of antibiotic stress E. coli overexpresses the global activator protein MarA which besides inducing MDR efflux pump AcrAB also down- regulates synthesis of the porin OmpF.	antibacterial_free_fatty_acids/penem/diaminopyrimidine/macrolide/penam/rifamycin/cephamycin/aminocoumarin/carbapenem/aminoglycoside/cephalosporin/fluoroquinolone/tetracycline/triclosan/acridine_dye/monobactam/glycylcycline/phenicol
SAMN11840202	contig00004	202570	203978	-	mdtK	1-1409/1425	========/======	2/4	98.74	75.34	card	CP014358.1:2161326-2162751	A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin doxorubicin and acriflavine.	glycylcycline/fluoroquinolone/tetracycline/acridine_dye
SAMN11840202	contig00007	134424	135056	-	CRP	1-633/633	===============	0/0	100.00	99.68	card	AP009048.1:4153664-4154297	CRP is a global regulator that represses MdtEF multidrug efflux pump expression.	tetracycline/triclosan/acridine_dye/fluoroquinolone/penam/macrolide/phenicol/monobactam/glycylcycline/aminocoumarin/aminoglycoside/carbapenem/diaminopyrimidine/antibacterial_free_fatty_acids
SAMN11840202	contig00008	37607	38800	+	Escherichia_coli_acrA	1-1194/1194	===============	0/0	100.00	100.00	card	U00096.3:484426-485620	AcrA is a subunit of the AcrAB-TolC multidrug efflux system that in E. coli.	rifamycin/macrolide/penam/diaminopyrimidine/antibacterial_free_fatty_acids/glycylcycline/monobactam/phenicol/acridine_dye/tetracycline/triclosan/cephalosporin/fluoroquinolone/carbapenem/aminoglycoside/aminocoumarin
SAMN11840202	contig00008	38823	41972	+	acrB	1-3150/3150	===============	0/0	100.00	100.00	card	U00096.3:481254-484404	Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.	antibacterial_free_fatty_acids/diaminopyrimidine/rifamycin/penam/macrolide/aminoglycoside/carbapenem/aminocoumarin/phenicol/monobactam/glycylcycline/fluoroquinolone/cephalosporin/tetracycline/triclosan/acridine_dye
SAMN11840202	contig00008	126851	128008	+	Escherichia_coli_ampH	1-1158/1158	===============	0/0	100.00	100.00	card	AP012030.1:395554-396712	AmpH is a class C ampC-like beta-lactamase and penicillin-binding protein identified in Escherichia coli.	cephalosporin/penam
SAMN11840202	contig00010	97802	99268	-	mdtP	1-1467/1467	===============	0/0	100.00	100.00	card	AP009048.1:4303043-4304510	Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride	benzalkonium_chloride/isoniazid/lincosamide/antibacterial_free_fatty_acids/bicyclomycin/diaminopyrimidine/penam/macrolide/nitroimidazole/rifamycin/nucleoside/rhodamine/peptide/fluoroquinolone/cephalosporin/tetracycline/acridine_dye/oxazolidinone/fosfomycin/phenicol/glycylcycline
SAMN11840202	contig00010	99265	101316	-	mdtO	1-2052/2052	===============	0/0	100.00	99.95	card	AP009048.1:4304506-4306558	Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride	nucleoside/rifamycin/nitroimidazole/macrolide/penam/diaminopyrimidine/bicyclomycin/antibacterial_free_fatty_acids/isoniazid/lincosamide/benzalkonium_chloride/glycylcycline/phenicol/fosfomycin/oxazolidinone/acridine_dye/tetracycline/cephalosporin/fluoroquinolone/peptide/rhodamine
SAMN11840202	contig00010	101316	102347	-	mdtN	1-1032/1032	===============	0/0	100.00	100.00	card	AP009048.1:4306557-4307589	Multidrug resistance efflux pump. Could be involved in resistance to puromycin acriflavine and tetraphenylarsonium chloride.	tetracycline/oxazolidinone/acridine_dye/cephalosporin/fluoroquinolone/glycylcycline/phenicol/fosfomycin/peptide/rhodamine/macrolide/penam/nucleoside/rifamycin/nitroimidazole/isoniazid/lincosamide/benzalkonium_chloride/diaminopyrimidine/antibacterial_free_fatty_acids/bicyclomycin
SAMN11840202	contig00012	85775	87262	+	tolC	1-1488/1488	===============	0/0	100.00	100.00	card	FJ768952:1-1489	TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex.	rifamycin/triclosan/tetracycline/glycylcycline/cephamycin/carbapenem/aminoglycoside/macrolide/penam/pleuromutilin/nitroimidazole/nucleoside/isoniazid/lincosamide/benzalkonium_chloride/antibacterial_free_fatty_acids/bicyclomycin/penem/diaminopyrimidine/cephalosporin/fluoroquinolone/oxazolidinone/acridine_dye/fosfomycin/monobactam/phenicol/rhodamine/peptide/aminocoumarin
SAMN11840202	contig00013	50531	51007	-	mphB	1-477/477	===============	0/0	100.00	98.32	card	AE005174.2:3397371-3397848	The mphB gene encodes for MPH(2')-II. This enzymes phosphorylates 14-membered and 16-membered macrolides.  It phosphorylates macrolides in GTP- dependent manner at 2'-OH hydroxyl of desosamine sugar of macrolides.	macrolide
SAMN11840202	contig00013	71693	74806	-	acrD	1-3114/3114	===============	0/0	100.00	100.00	card	AP009048.1:2586251-2589365	AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole and is regulated by baeRS and cpxAR.	aminocoumarin/aminoglycoside/carbapenem/diaminopyrimidine/antibacterial_free_fatty_acids/tetracycline/triclosan/acridine_dye/fluoroquinolone/penam/macrolide/phenicol/monobactam/glycylcycline
SAMN11840202	contig00017	52034	53572	-	emrY	1-1539/1539	===============	0/0	100.00	98.83	card	D78168:1592-3131	emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB.	oxazolidinone/acridine_dye/tetracycline/cephalosporin/fluoroquinolone/glycylcycline/phenicol/fosfomycin/peptide/rhodamine/macrolide/penam/nucleoside/rifamycin/nitroimidazole/lincosamide/isoniazid/benzalkonium_chloride/diaminopyrimidine/bicyclomycin/antibacterial_free_fatty_acids
SAMN11840202	contig00017	53572	54627	-	emrK	1-1056/1056	===============	0/0	100.00	99.72	card	D78168:537-1593	emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC it mediates multidrug efflux.	macrolide/penam/rifamycin/nitroimidazole/nucleoside/isoniazid/lincosamide/benzalkonium_chloride/bicyclomycin/antibacterial_free_fatty_acids/diaminopyrimidine/cephalosporin/fluoroquinolone/acridine_dye/oxazolidinone/tetracycline/fosfomycin/glycylcycline/phenicol/rhodamine/peptide
SAMN11840202	contig00017	55151	55765	+	evgA	1-615/615	===============	0/0	100.00	99.02	card	BA000007.3:3212026-3212641	EvgA when phosphorylated is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner it can be phosphorylated in the absence of EvgS when overexpressed.	diaminopyrimidine/antibacterial_free_fatty_acids/bicyclomycin/benzalkonium_chloride/isoniazid/lincosamide/nucleoside/nitroimidazole/rifamycin/penam/macrolide/aminoglycoside/carbapenem/aminocoumarin/peptide/rhodamine/phenicol/monobactam/glycylcycline/fosfomycin/triclosan/tetracycline/oxazolidinone/acridine_dye/fluoroquinolone/cephalosporin
SAMN11840202	contig00017	55770	59363	+	evgS	1-3594/3594	===============	0/0	100.00	99.11	card	U00096:2484374-2487968	EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.	triclosan/tetracycline/acridine_dye/oxazolidinone/fluoroquinolone/cephalosporin/phenicol/monobactam/glycylcycline/fosfomycin/aminocoumarin/peptide/rhodamine/aminoglycoside/carbapenem/penam/macrolide/nucleoside/nitroimidazole/rifamycin/benzalkonium_chloride/isoniazid/lincosamide/diaminopyrimidine/antibacterial_free_fatty_acids/bicyclomycin
SAMN11840202	contig00018	15251	16072	-	bacA	1-822/822	===============	0/0	100.00	100.00	card	U00096.3:3203310-3204132	The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin.	peptide
SAMN11840202	contig00023	7667	9310	-	eptA	1-1644/1644	===============	0/0	100.00	99.94	card	AP009048:4338625-4340269	PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine resulting in a less negative cell membrane and decreased binding of polymyxin B.	peptide
SAMN11840202	contig00023	51538	52671	-	Escherichia_coli_ampC	1-1134/1134	===============	0/0	100.00	97.27	card	NC_000913.3:4377811-4378945	A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics.	cephalosporin/penam
SAMN11840202	contig00024	3696	5234	-	emrB	1-1539/1539	===============	0/0	100.00	100.00	card	U00096:2812616-2814155	emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP) nalidixic acid and thioloactomycin.	rhodamine/peptide/fosfomycin/glycylcycline/phenicol/cephalosporin/fluoroquinolone/tetracycline/acridine_dye/oxazolidinone/antibacterial_free_fatty_acids/bicyclomycin/diaminopyrimidine/lincosamide/isoniazid/benzalkonium_chloride/rifamycin/nitroimidazole/nucleoside/macrolide/penam
SAMN11840202	contig00024	5251	6423	-	emrA	1-1173/1173	===============	0/0	100.00	99.92	card	AP009048:2810083-2811256	EmrA is a membrane fusion protein providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli a Gram-negative bacterium.	benzalkonium_chloride/isoniazid/lincosamide/diaminopyrimidine/bicyclomycin/antibacterial_free_fatty_acids/penam/macrolide/nucleoside/nitroimidazole/rifamycin/peptide/rhodamine/acridine_dye/oxazolidinone/tetracycline/fluoroquinolone/cephalosporin/phenicol/glycylcycline/fosfomycin
SAMN11840202	contig00024	6550	7080	-	emrR	1-531/531	===============	0/0	100.00	99.81	card	U00096.3:2810770-2811301	EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression.	rifamycin/nitroimidazole/nucleoside/macrolide/penam/bicyclomycin/antibacterial_free_fatty_acids/diaminopyrimidine/lincosamide/isoniazid/benzalkonium_chloride/fosfomycin/glycylcycline/phenicol/cephalosporin/fluoroquinolone/oxazolidinone/acridine_dye/tetracycline/rhodamine/peptide
SAMN11840202	contig00033	19630	20838	+	mdtH	1-1209/1209	===============	0/0	100.00	99.92	card	U00096:1124118-1125327	Multidrug resistance protein MdtH	nitroimidazole/rifamycin/nucleoside/penam/macrolide/antibacterial_free_fatty_acids/bicyclomycin/diaminopyrimidine/benzalkonium_chloride/isoniazid/lincosamide/fosfomycin/phenicol/glycylcycline/fluoroquinolone/cephalosporin/tetracycline/acridine_dye/oxazolidinone/rhodamine/peptide
SAMN11840202	contig00033	29467	30693	+	mdtG	1-1227/1227	===============	0/0	100.00	99.43	card	CP000800.1:1191728-1192955	The MdtG protein also named YceE appears to be a member of the major facilitator superfamily of transporters and it has been reported when overexpressed to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon.	macrolide/penam/rifamycin/nitroimidazole/nucleoside/isoniazid/lincosamide/benzalkonium_chloride/bicyclomycin/antibacterial_free_fatty_acids/diaminopyrimidine/cephalosporin/fluoroquinolone/acridine_dye/oxazolidinone/tetracycline/fosfomycin/glycylcycline/phenicol/rhodamine/peptide
SAMN11840202	contig00035	41010	41423	+	H-NS	1-414/414	===============	0/0	100.00	99.28	card	BA000007.3:1737691-1738105	H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE mdtE and emrK as well as nearby genes of many RND-type multidrug exporters.	bicyclomycin/antibacterial_free_fatty_acids/diaminopyrimidine/benzalkonium_chloride/isoniazid/lincosamide/nitroimidazole/rifamycin/nucleoside/penam/macrolide/aminoglycoside/carbapenem/rhodamine/cephamycin/aminocoumarin/peptide/fosfomycin/phenicol/glycylcycline/monobactam/fluoroquinolone/cephalosporin/acridine_dye/oxazolidinone/triclosan/tetracycline
SAMN11840202	contig00043	12125	13429	-	Escherichia_coli_ampC1_beta-lactamase	1-1305/1305	===============	0/0	100.00	100.00	card	FN649414.1:2765051-2766356	An ampC-like beta-lactamase identified from Escherichia coli.	cephalosporin/penam
SAMN11840202	contig00044	462	1286	+	gadX	1-825/825	===============	0/0	100.00	100.00	card	AP009048.1:3974605-3975430	GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance.	aminoglycoside/diaminopyrimidine/carbapenem/antibacterial_free_fatty_acids/aminocoumarin/phenicol/glycylcycline/monobactam/acridine_dye/tetracycline/triclosan/penam/fluoroquinolone/macrolide
SAMN11840202	contig00044	1654	2382	+	gadW	1-729/729	===============	0/0	100.00	94.65	card	CP015085.1:2551712-2552441	GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and in situations where GadX is missing activates gadA and gadBC.	phenicol/monobactam/glycylcycline/penam/fluoroquinolone/macrolide/triclosan/tetracycline/acridine_dye/antibacterial_free_fatty_acids/aminoglycoside/carbapenem/diaminopyrimidine/aminocoumarin
SAMN11840202	contig00044	2745	5858	-	mdtF	1-3114/3114	===============	0/0	100.00	99.97	card	U00096:3660414-3663528	MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex.	triclosan/tetracycline/acridine_dye/macrolide/fluoroquinolone/penam/monobactam/glycylcycline/phenicol/aminocoumarin/carbapenem/diaminopyrimidine/aminoglycoside/antibacterial_free_fatty_acids
SAMN11840202	contig00044	5883	7040	-	mdtE	1-1158/1158	===============	0/0	100.00	100.00	card	AP009048.1:3980026-3981184	MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA.	glycylcycline/monobactam/phenicol/acridine_dye/tetracycline/triclosan/macrolide/fluoroquinolone/penam/diaminopyrimidine/carbapenem/aminoglycoside/antibacterial_free_fatty_acids/aminocoumarin
SAMN11840202	contig00049	8136	8813	+	kdpE	1-678/678	===============	0/0	100.00	100.00	card	U00096.3:721056-721734	kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.	aminoglycoside
SAMN11840202	contig00049	12775	12918	+	kdpE	535-678/678	...........====	0/0	21.24	90.28	card	U00096.3:721056-721734	kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.	aminoglycoside
SAMN11840202	contig00050	22680	23032	-	Nocardia_rifampin_resistant_beta-subunit_of_RNA_polymerase_(rpoB2)	2980-3332/3489	......../...===	4/6	10.03	75.56	card	AP006618.1:4835200-4838689	Due to gene duplication the genomes of Nocardia species include both rifampin-sensitive beta-subunit of RNA polymerase (rpoB) and rifampin-resistant beta-subunit of RNA polymerase (rpoB2) genes with ~88% similarity between the two gene products. Expression of the rpoB2 variant results in replacement of rifampin sensitivity with rifampin resistance.	rifamycin
SAMN11840202	contig00055	17804	19036	-	mdtM	1-1233/1233	===============	0/0	100.00	96.27	card	U00096.3:4567287-4568520	Multidrug resistance protein MdtM	nitroimidazole/rifamycin/nucleoside/penam/macrolide/bicyclomycin/antibacterial_free_fatty_acids/diaminopyrimidine/benzalkonium_chloride/lincosamide/isoniazid/fosfomycin/phenicol/glycylcycline/fluoroquinolone/cephalosporin/oxazolidinone/acridine_dye/tetracycline/rhodamine/peptide
SAMN11840202	contig00057	2580	3826	+	tet(A)	1-1247/1275	===============	0/0	97.80	100.00	card	AF534183.1:2971-4246	TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria.	phenicol/glycylcycline/fosfomycin/tetracycline/oxazolidinone/acridine_dye/fluoroquinolone/cephalosporin/peptide/rhodamine/nucleoside/nitroimidazole/rifamycin/penam/macrolide/diaminopyrimidine/antibacterial_free_fatty_acids/bicyclomycin/benzalkonium_chloride/isoniazid/lincosamide
SAMN11840202	contig00063	8997	10370	-	cpxA	1-1374/1374	===============	0/0	100.00	98.98	card	BA000007.3:4903689-4905063	CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR which promotes efflux complex expression.	acridine_dye/tetracycline/triclosan/macrolide/fluoroquinolone/penam/glycylcycline/monobactam/phenicol/aminocoumarin/diaminopyrimidine/carbapenem/aminoglycoside/antibacterial_free_fatty_acids
SAMN11840202	contig00074	561	1373	+	NDM-5	1-813/813	===============	0/0	100.00	100.00	card	JN104597:115-928	New Delhi beta-lactamase NDM-5.	cephamycin/penam/cephalosporin/carbapenem
SAMN11840202	contig00074	1377	1742	+	determinant_of_bleomycin_resistance	1-366/366	===============	0/0	100.00	100.00	card	KC503911.1:9884-10250	A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter where it is co-expressed with an MBL and controlled by the same promoter region.	glycopeptide
SAMN11840202	contig00074	5686	6525	-	sul1	1-840/840	===============	0/0	100.00	100.00	card	JF969163:1054-1894	Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons.	sulfonamide
SAMN11840202	contig00074	7030	7809	-	aadA2	1-780/780	===============	0/0	100.00	99.87	card	AF156486:5013-5793	aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae Salmonella spp. Corynebacterium glutamicum C. freundii and Aeromonas spp.	aminoglycoside
SAMN11840202	contig00074	8229	8726	-	dfrA12	1-498/498	===============	0/0	100.00	100.00	card	GU585907.1:21606-22104	dfrA12 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae	diaminopyrimidine
SAMN11840202	contig00074	8727	8975	-	AAC(6')-Ib7	1-249/980	====...........	0/0	25.41	98.80	card	Y11946.1:1-981	AAC(6')-Ib7 is a plasmid-encoded aminoglycoside acetyltransferase in E. cloacae and C. freundii	aminoglycoside
SAMN11840202	contig00077	5190	8294	-	acrF	1-3105/3105	===============	0/0	100.00	99.97	card	U00096:3415033-3418138	AcrF is a inner membrane transporter similar to AcrB.	aminoglycoside/carbapenem/diaminopyrimidine/antibacterial_free_fatty_acids/aminocoumarin/cephamycin/phenicol/monobactam/glycylcycline/tetracycline/triclosan/acridine_dye/fluoroquinolone/penam/cephalosporin/macrolide
SAMN11840202	contig00077	8306	9272	-	acrE	192-1158/1158	..=============	0/0	83.51	99.90	card	U00096:3413864-3415022	AcrE is a membrane fusion protein similar to AcrA.	aminocoumarin/cephamycin/carbapenem/diaminopyrimidine/aminoglycoside/antibacterial_free_fatty_acids/triclosan/tetracycline/acridine_dye/cephalosporin/macrolide/penam/fluoroquinolone/monobactam/glycylcycline/phenicol
SAMN11840202	contig00080	1250	2005	-	rmtB	1-756/756	===============	0/0	100.00	100.00	card	AM886293.1:116480-117236	RmtB is a 16S rRNA methyltransferase that targets mature or nearly mature 30S subunits. It transfers a methyl group from S-adenosyl-L-methionine to N7-G1405 of the 16S rRNA an aminoglycoside binding site.	aminoglycoside
SAMN11840202	contig00080	2175	3035	-	TEM-1	1-861/861	===============	0/0	100.00	99.88	card	AL513383:161911-162772	TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins.	penam/cephalosporin/penem/monobactam
SAMN11840202	contig00080	7165	8067	-	mphA	1-903/906	===============	0/0	99.67	100.00	card	D16251.1:1626-2532	The mphA gene encodes for resistance enzyme MPH(2')-I which preferentially inactivate 14-membered macrolides (e.g.erythromycin telithromycin roxithromycin) over 16-membered macrolides (e.g.tylosin spiramycin). It phosphorylates macrolides at 2'-OH hydroxyl of desosamine sugar of macrolides in a GTP-dependent manner.	macrolide
SAMN11840202	contig00088	2703	3578	-	CTX-M-15	1-876/876	===============	0/0	100.00	100.00	card	AY044436:1436-2312	CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family	cephalosporin
SAMN11840202	contig00102	130	779	+	OXA-368	2072-2721/2721	...........====	0/0	23.89	99.08	card	KT736121.1:1-2722	OXA-368 is a beta-lactamase found in Aeromonas sobria. From the Lahey list of OXA beta-lactamases.	cephalosporin/penam
SAMN11840202	contig00102	844	1674	+	OXA-1	1-831/831	===============	0/0	100.00	100.00	card	JN420336.1:1400-2231	OXA-1 is a beta-lactamase found in E. coli	penam/cephalosporin
SAMN11840202	contig00102	1812	2256	+	catB3	1-445/633	===========....	0/0	70.30	99.78	card	JX101693.1:58201-58834	catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium Acinetobacter baumannii and Escherichia coli	phenicol