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view java-genomics-toolkit/src/edu/unc/genomics/wigmath/MovingAverageSmooth.java @ 0:1daf3026d231
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author | timpalpant |
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date | Mon, 13 Feb 2012 21:55:55 -0500 |
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package edu.unc.genomics.wigmath; import java.io.IOException; import java.util.Iterator; import org.apache.commons.math.stat.descriptive.DescriptiveStatistics; import org.apache.log4j.Logger; import org.broad.igv.bbfile.WigItem; import com.beust.jcommander.Parameter; import edu.unc.genomics.PositiveIntegerValidator; import edu.unc.genomics.io.WigFile; import edu.unc.genomics.io.WigFileException; public class MovingAverageSmooth extends WigMathTool { private static final Logger log = Logger.getLogger(MovingAverageSmooth.class); @Parameter(names = {"-i", "--input"}, description = "Input file", required = true) public WigFile inputFile; @Parameter(names = {"-w", "--width"}, description = "Width of kernel (bp)") public int width = 10; WigFile input; DescriptiveStatistics stats; @Override public void setup() { inputs.add(inputFile); log.debug("Initializing statistics"); stats = new DescriptiveStatistics(); stats.setWindowSize(width); } @Override public float[] compute(String chr, int start, int stop) throws IOException, WigFileException { log.debug("Smoothing chunk "+chr+":"+start+"-"+stop); // Pad the query so that we can provide values for the ends int queryStart = Math.max(start-width/2, input.getChrStart(chr)); int queryStop = Math.min(stop+width/2, input.getChrStop(chr)); Iterator<WigItem> result = input.query(chr, queryStart, queryStop); float[] data = WigFile.flattenData(result, queryStart, queryStop); float[] smoothed = new float[stop-start+1]; for (int bp = start; bp <= stop; bp++) { stats.addValue(data[bp-queryStart]); if (bp-start-width/2 >= 0) { smoothed[bp-start-width/2] = (float) stats.getMean(); } } return smoothed; } /** * @param args * @throws WigFileException * @throws IOException */ public static void main(String[] args) throws IOException, WigFileException { new MovingAverageSmooth().instanceMain(args); } }