Mercurial > repos > ucsb-phylogenetics > ucsb_phylogenetics
diff phylobayes_README.txt @ 0:bbf0d9e9b82a draft
Uploaded
author | ucsb-phylogenetics |
---|---|
date | Thu, 31 May 2012 19:44:16 -0400 |
parents | |
children |
line wrap: on
line diff
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/phylobayes_README.txt Thu May 31 19:44:16 2012 -0400 @@ -0,0 +1,70 @@ +Phylobayes Galaxy Installation and Configuration Instructions + +Phylobayes original binaries written by: Lartillot N., Philippe H. Molecular Biology and Evolution + +Galaxy and Perl wrapper script written by: Roger Ngo and Todd H. Oakley, UCSB + + + Phylobayes - Bayesian phylogenetic software based on mixture models. + Lartillot N., Philippe H. Molecular Biology and Evolution. 2004 21(6):1095-1109. + + PhyloBayes is a Bayesian Monte Carlo Markov Chain (MCMC) sampler for phylogenetic reconstruction using protein alignments. + Compared to other phylogenetic MCMC samplers (e.g. MrBayes ), the main distinguishing feature of PhyloBayes is the underlying probabilistic model, CAT. + It is particularly well suited for large multigene alignments, such as those used in phylogenomics. + + The version 2.3 of phylobayes allows for divergence time estimation, posterior predictive analyses, including compositional homogeneity and saturation tests, + data recoding (analogous to R/Y coding, but for amino-acids), and cross-validation. It also implements a more efficient tree searching MCMC algorithm. + + http://www.atgc-montpellier.fr/phylobayes/ + + "A Bayesian Mixture Model for Across-Site Heterogeneities in the Amino-Acid Replacement Process." + http://www.atgc-montpellier.fr/download/papers/cat_2004.pdf + Lartillot N., Philippe H. + Molecular Biology and Evolution. 2004 21(6):1095-1109. + + "Computing Bayes factors using thermodynamic integration." + http://www.atgc-montpellier.fr/download/papers/phylobayes_2006.pdf + Lartillot N., Philippe H. + Systematic Biology. 2006 55:195-207. + + Suppression of long-branch attraction artefacts in the animal phylogeny using a site-heterogeneous model." + http://www.atgc-montpellier.fr/download/papers/cat_2007.pdf + Lartillot N., Brinkmann H., Philippe H. + BMC Evolutionary Biology. 2007 Feb 8;7 Suppl 1:S4. + + "Phylogenomics." + http://www.atgc-montpellier.fr/download/papers/phylogenomics_2005.pdf + Philippe H., Delsuc F., Brinkmann H., Lartillot N. + Annual Review of Ecology, Evolution and Systematics. 2005 36,541-562. + + + +Included in this package: + +* pb.pl - Perl wrapper script for the Galaxy tool +* pb.xml - Galaxy Phylobayes XML file +* phylobayes_README - Documentation file + +Dependencies: PHYLOBAYES 3.3b must be installed on the Galaxy user account. + +How to install Phylobayes + +1. Ensure phylobayes 3.3b is installed. + +2. Modify the $phylobayes_path and $readPB_path to reflect the location +of pb and readpb in your user account. The default is listed below: + +my $phylobayes_path = '/home/galaxy/pkgs/phylobayes3.3b/exe_lin64/pb'; +my $readPB_path = '/home/galaxy/pkgs/phylobayes3.3b/exe_lin64/readpb'; + +3. Copy pb.pl and pb.xml to a folder in the /galaxy-dist/tools directory. + +4. Add the XML tool into the tool_conf.xml file in galaxy-dist/ + +5. Restart Galaxy with: + +./run.sh --stop-daemon + +and then + +./run.sh --reload --daemon \ No newline at end of file