Mercurial > repos > youngkim > ezbamqc
view ezBAMQC/src/htslib/cram/cram_stats.c @ 1:b4ff32b63fcd
Uploaded
author | cshl-bsr |
---|---|
date | Tue, 29 Mar 2016 15:25:51 -0400 |
parents | dfa3745e5fd8 |
children |
line wrap: on
line source
/* Copyright (c) 2012-2013 Genome Research Ltd. Author: James Bonfield <jkb@sanger.ac.uk> Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met: 1. Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer. 2. Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution. 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger Institute nor the names of its contributors may be used to endorse or promote products derived from this software without specific prior written permission. THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. */ #ifdef HAVE_CONFIG_H #include "io_lib_config.h" #endif #include <stdio.h> #include <errno.h> #include <assert.h> #include <stdlib.h> #include <string.h> #include <zlib.h> #include <sys/types.h> #include <sys/stat.h> #include <math.h> #include <ctype.h> #include "cram/cram.h" #include "cram/os.h" cram_stats *cram_stats_create(void) { return calloc(1, sizeof(cram_stats)); } void cram_stats_add(cram_stats *st, int32_t val) { st->nsamp++; //assert(val >= 0); if (val < MAX_STAT_VAL && val >= 0) { st->freqs[val]++; } else { khint_t k; int r; if (!st->h) { st->h = kh_init(m_i2i); } k = kh_put(m_i2i, st->h, val, &r); if (r == 0) kh_val(st->h, k)++; else if (r != -1) kh_val(st->h, k) = 1; else ; // FIXME: handle error } } void cram_stats_del(cram_stats *st, int32_t val) { st->nsamp--; //assert(val >= 0); if (val < MAX_STAT_VAL && val >= 0) { st->freqs[val]--; assert(st->freqs[val] >= 0); } else if (st->h) { khint_t k = kh_get(m_i2i, st->h, val); if (k != kh_end(st->h)) { if (--kh_val(st->h, k) == 0) kh_del(m_i2i, st->h, k); } else { fprintf(stderr, "Failed to remove val %d from cram_stats\n", val); st->nsamp++; } } else { fprintf(stderr, "Failed to remove val %d from cram_stats\n", val); st->nsamp++; } } void cram_stats_dump(cram_stats *st) { int i; fprintf(stderr, "cram_stats:\n"); for (i = 0; i < MAX_STAT_VAL; i++) { if (!st->freqs[i]) continue; fprintf(stderr, "\t%d\t%d\n", i, st->freqs[i]); } if (st->h) { khint_t k; for (k = kh_begin(st->h); k != kh_end(st->h); k++) { if (!kh_exist(st->h, k)) continue; fprintf(stderr, "\t%d\t%d\n", kh_key(st->h, k), kh_val(st->h, k)); } } } #if 1 /* Returns the number of bits set in val; it the highest bit used */ static int nbits(int v) { static const int MultiplyDeBruijnBitPosition[32] = { 1, 10, 2, 11, 14, 22, 3, 30, 12, 15, 17, 19, 23, 26, 4, 31, 9, 13, 21, 29, 16, 18, 25, 8, 20, 28, 24, 7, 27, 6, 5, 32 }; v |= v >> 1; // first up to set all bits 1 after the first 1 */ v |= v >> 2; v |= v >> 4; v |= v >> 8; v |= v >> 16; // DeBruijn magic to find top bit return MultiplyDeBruijnBitPosition[(uint32_t)(v * 0x07C4ACDDU) >> 27]; } #endif /* * Computes entropy from integer frequencies for various encoding methods and * picks the best encoding. * * FIXME: we could reuse some of the code here for the actual encoding * parameters too. Eg the best 'k' for SUBEXP or the code lengths for huffman. * * Returns the best codec to use. */ enum cram_encoding cram_stats_encoding(cram_fd *fd, cram_stats *st) { enum cram_encoding best_encoding = E_NULL; int best_size = INT_MAX, bits; int nvals, i, ntot = 0, max_val = 0, min_val = INT_MAX, k; int *vals = NULL, *freqs = NULL, vals_alloc = 0, *codes; //cram_stats_dump(st); /* Count number of unique symbols */ for (nvals = i = 0; i < MAX_STAT_VAL; i++) { if (!st->freqs[i]) continue; if (nvals >= vals_alloc) { vals_alloc = vals_alloc ? vals_alloc*2 : 1024; vals = realloc(vals, vals_alloc * sizeof(int)); freqs = realloc(freqs, vals_alloc * sizeof(int)); if (!vals || !freqs) { if (vals) free(vals); if (freqs) free(freqs); return E_HUFFMAN; // Cannot do much else atm } } vals[nvals] = i; freqs[nvals] = st->freqs[i]; ntot += freqs[nvals]; if (max_val < i) max_val = i; if (min_val > i) min_val = i; nvals++; } if (st->h) { khint_t k; int i; for (k = kh_begin(st->h); k != kh_end(st->h); k++) { if (!kh_exist(st->h, k)) continue; if (nvals >= vals_alloc) { vals_alloc = vals_alloc ? vals_alloc*2 : 1024; vals = realloc(vals, vals_alloc * sizeof(int)); freqs = realloc(freqs, vals_alloc * sizeof(int)); if (!vals || !freqs) return E_HUFFMAN; // Cannot do much else atm } i = kh_key(st->h, k); vals[nvals]=i; freqs[nvals] = kh_val(st->h, k); ntot += freqs[nvals]; if (max_val < i) max_val = i; if (min_val > i) min_val = i; nvals++; } } st->nvals = nvals; assert(ntot == st->nsamp); if (nvals <= 1) { free(vals); free(freqs); return E_HUFFMAN; } if (fd->verbose > 1) fprintf(stderr, "Range = %d..%d, nvals=%d, ntot=%d\n", min_val, max_val, nvals, ntot); /* Theoretical entropy */ // if (fd->verbose > 1) { // double dbits = 0; // for (i = 0; i < nvals; i++) { // dbits += freqs[i] * log((double)freqs[i]/ntot); // } // dbits /= -log(2); // if (fd->verbose > 1) // fprintf(stderr, "Entropy = %f\n", dbits); // } if (nvals > 1 && ntot > 256) { #if 0 /* * CRUDE huffman estimator. Round to closest and round up from 0 * to 1 bit. * * With and without ITF8 incase we have a few discrete values but with * large magnitude. * * Note rans0/arith0 and Z_HUFFMAN_ONLY vs internal huffman can be * compared in this way, but order-1 (eg rans1) or maybe LZ77 modes * may detect the correlation of high bytes to low bytes in multi- * byte values. So this predictor breaks down. */ double dbits = 0; // entropy + ~huffman double dbitsH = 0; double dbitsE = 0; // external entropy + ~huffman double dbitsEH = 0; int F[256] = {0}, n = 0; double e = 0; // accumulated error bits for (i = 0; i < nvals; i++) { double x; int X; unsigned int v = vals[i]; //Better encoding would cope with sign. //v = ABS(vals[i])*2+(vals[i]<0); if (!(v & ~0x7f)) { F[v] += freqs[i], n+=freqs[i]; } else if (!(v & ~0x3fff)) { F[(v>>8) |0x80] += freqs[i]; F[ v &0xff] += freqs[i], n+=2*freqs[i]; } else if (!(v & ~0x1fffff)) { F[(v>>16)|0xc0] += freqs[i]; F[(v>>8 )&0xff] += freqs[i]; F[ v &0xff] += freqs[i], n+=3*freqs[i]; } else if (!(v & ~0x0fffffff)) { F[(v>>24)|0xe0] += freqs[i]; F[(v>>16)&0xff] += freqs[i]; F[(v>>8 )&0xff] += freqs[i]; F[ v &0xff] += freqs[i], n+=4*freqs[i]; } else { F[(v>>28)|0xf0] += freqs[i]; F[(v>>20)&0xff] += freqs[i]; F[(v>>12)&0xff] += freqs[i]; F[(v>>4 )&0xff] += freqs[i]; F[ v &0x0f] += freqs[i], n+=5*freqs[i]; } x = -log((double)freqs[i]/ntot)/.69314718055994530941; X = x+0.5; if ((int)(x+((double)e/freqs[i])+.5)>X) { X++; } else if ((int)(x+((double)e/freqs[i])+.5)<X) { X--; } e-=freqs[i]*(X-x); X += (X==0); //fprintf(stderr, "Val %d = %d x %d (ent %f, %d) e %f\n", i, v, freqs[i], x, X, e); dbits += freqs[i] * x; dbitsH += freqs[i] * X; } for (i = 0; i < 256; i++) { if (F[i]) { double x = -log((double)F[i]/n)/.69314718055994530941; int X = x+0.5; X += (X==0); dbitsE += F[i] * x; dbitsEH += F[i] * X; //fprintf(stderr, "Val %d = %d x %d (e %f, %d)\n", i, i, F[i], x, X); } } //fprintf(stderr, "CORE Entropy = %f, %f\n", dbits/8, dbitsH/8); //fprintf(stderr, "Ext. Entropy = %f, %f\n", dbitsE/8, dbitsEH/8); if (dbitsE < 1000 || dbitsE / dbits > 1.1) { //fprintf(stderr, "=> %d < 200 ? E_HUFFMAN : E_BETA\n", nvals); free(vals); free(freqs); return nvals < 200 ? E_HUFFMAN : E_BETA; } #endif free(vals); free(freqs); return E_EXTERNAL; } /* * Avoid complex stats for now, just do heuristic of HUFFMAN for small * alphabets and BETA for anything large. */ free(vals); free(freqs); return nvals < 200 ? E_HUFFMAN : E_BETA; //return E_HUFFMAN; //return E_EXTERNAL; /* We only support huffman now anyway... */ //free(vals); free(freqs); return E_HUFFMAN; /* Beta */ bits = nbits(max_val - min_val) * ntot; if (fd->verbose > 1) fprintf(stderr, "BETA = %d\n", bits); if (best_size > bits) best_size = bits, best_encoding = E_BETA; #if 0 /* Unary */ if (min_val >= 0) { for (bits = i = 0; i < nvals; i++) bits += freqs[i]*(vals[i]+1); if (fd->verbose > 1) fprintf(stderr, "UNARY = %d\n", bits); if (best_size > bits) best_size = bits, best_encoding = E_NULL; //E_UNARY; } /* Gamma */ for (bits = i = 0; i < nvals; i++) bits += ((nbits(vals[i]-min_val+1)-1) + nbits(vals[i]-min_val+1)) * freqs[i]; if (fd->verbose > 1) fprintf(stderr, "GAMMA = %d\n", bits); if (best_size > bits) best_size = bits, best_encoding = E_GAMMA; /* Subexponential */ for (k = 0; k < 10; k++) { for (bits = i = 0; i < nvals; i++) { if (vals[i]-min_val < (1<<k)) bits += (1 + k)*freqs[i]; else bits += (nbits(vals[i]-min_val)*2-k)*freqs[i]; } if (fd->verbose > 1) fprintf(stderr, "SUBEXP%d = %d\n", k, bits); if (best_size > bits) best_size = bits, best_encoding = E_SUBEXP; } #endif /* byte array len */ /* byte array stop */ /* External? Guesswork! */ /* Huffman */ // qsort(freqs, nvals, sizeof(freqs[0]), sort_freqs); // for (i = 0; i < nvals; i++) { // fprintf(stderr, "%d = %d\n", i, freqs[i]); // vals[i] = 0; // } /* Grow freqs to 2*freqs, to store sums */ /* Vals holds link data */ freqs = realloc(freqs, 2*nvals*sizeof(*freqs)); codes = calloc(2*nvals, sizeof(*codes)); if (!freqs || !codes) return E_HUFFMAN; // Cannot do much else atm /* Inefficient, use pointers to form chain so we can insert and maintain * a sorted list? This is currently O(nvals^2) complexity. */ for (;;) { int low1 = INT_MAX, low2 = INT_MAX; int ind1 = 0, ind2 = 0; for (i = 0; i < nvals; i++) { if (freqs[i] < 0) continue; if (low1 > freqs[i]) low2 = low1, ind2 = ind1, low1 = freqs[i], ind1 = i; else if (low2 > freqs[i]) low2 = freqs[i], ind2 = i; } if (low2 == INT_MAX) break; //fprintf(stderr, "Merge ind %d (%d), %d (%d) = %d+%d, => %d=%d\n", // ind1, vals[ind1], ind2, vals[ind2], low1, low2, // nvals, low1+low2); freqs[nvals] = low1 + low2; codes[ind1] = nvals; codes[ind2] = nvals; freqs[ind1] *= -1; freqs[ind2] *= -1; nvals++; } nvals = nvals/2+1; for (i = 0; i < nvals; i++) { int code_len = 0; for (k = codes[i]; k; k = codes[k]) code_len++; codes[i] = code_len; freqs[i] *= -1; //fprintf(stderr, "%d / %d => %d\n", vals[i], freqs[i], codes[i]); } for (bits = i = 0; i < nvals; i++) { bits += freqs[i] * codes[i]; } if (fd->verbose > 1) fprintf(stderr, "HUFFMAN = %d\n", bits); if (best_size >= bits) best_size = bits, best_encoding = E_HUFFMAN; free(codes); free(vals); free(freqs); return best_encoding; } void cram_stats_free(cram_stats *st) { if (st->h) kh_destroy(m_i2i, st->h); free(st); }