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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/MANIFEST.in Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,20 @@ + +# BASIC INCLUDES +include setup.py +include ezBAMQC +include README.rst + +# DOC INCLUDES +include doc/* + +# SRC ezBAMQC INCLUDES +include src/ezBAMQC/* + +# SRC HTSLIB INCLUDES +include src/htslib/* + +#SRC HTSLIB HEADER INCLUDES +include src/htslib/htslib/* + +#SRC HTSLIB CRAM INCLUDES +include src/htslib/cram/*
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/Makefile Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,133 @@ +# Makefile for ezBAMQC, utilities for the Sequence Alignment/Map format. +# +# Version 0.6.5 +# +# Copyright (C) 2015 Bioinformatics Shared Resource, CSHL. +# Portions copyright (C) 2015 Cold Spring Harbor Laboratory. +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +CC = g++ +CPPFLAGS = $(DFLAGS) $(INCLUDES) +CFLAGS = -g -fpermissive -Wall -O9 -O3 -std=c++11 -fPIC +LDFLAGS = -O9 -fpermissive +LDLIBS = +DFLAGS= -D_FILE_OFFSET_BITS=64 -D_LARGEFILE64_SOURCE -D_CURSES_LIB=1 +LOBJS= src/ezBAMQC/GeneFeatures.o src/ezBAMQC/rRNA.o src/ezBAMQC/IntervalTree.o src/ezBAMQC/InnerDist_prof.o \ + src/ezBAMQC/Results.o src/ezBAMQC/Mappability.o src/ezBAMQC/Coverage_prof.o src/ezBAMQC/parseBAM.o + +INCLUDES= -I$(HTSDIR) +LIBCURSES= -lcurses # -lXCurses + +prefix = /usr/local +exec_prefix = $(prefix) +bindir = $(exec_prefix)/bin +mandir = $(prefix)/share/man +man1dir = $(mandir)/man1 + +MKDIR_P = mkdir -p +#INSTALL = install -p +#INSTALL_PROGRAM = $(INSTALL) +#INSTALL_DATA = $(INSTALL) -m 644 +#INSTALL_DIR = $(MKDIR_P) -m 755 + + +PROGRAMS = libBAMqc.so + + +all: $(PROGRAMS) + + +# Adjust $(HTSDIR) to point to your top-level htslib directory +HTSDIR = ./src/htslib +include $(HTSDIR)/htslib.mk +HTSLIB = $(HTSDIR)/libhts.a +BGZIP = $(HTSDIR)/bgzip + + +PACKAGE_VERSION = 0.5 + + +.SUFFIXES: .cpp .o + +.cpp.o: + $(CC) $(CFLAGS) $(CPPFLAGS) -c -o $@ $< + + +#lib:libbam.a + +#libbam.a:$(LOBJS) +# $(AR) -csru $@ $(LOBJS) + +#libBAMqc.so: $(LOBJS) $(HTSLIB) +# $(CC) -pthread $(LDFLAGS) -o $@ $(AOBJS) $(HTSLIB) $(LDLIBS) $(LIBCURSES) -lm -lz + +libBAMqc.so: $(LOBJS) $(HTSLIB) +# $(CC) -shared -Wl,-soname, libBAMqc.so.$(PACKAGE_VERSION) -lpthread $(LDFLAGS) -o $@ $(LOBJS) $(HTSLIB) $(LDLIBS) -lz -lm + $(CC) -shared -lpthread $(LDFLAGS) -o $@ $(LOBJS) $(HTSLIB) $(LDLIBS) -lz -lm +# ln -sf $@ libBAMqc.so.$(PACKAGE_VERSION) + +Constants_h = src/ezBAMQC/Constants.h +IntervalTree_h = src/ezBAMQC/IntervalTree.h $(Constants_h) +GeneFeatures_h = src/ezBAMQC/GeneFeatures.h $(Constants_h) +rRNA_h = src/ezBAMQC/rRNA.h $(IntervalTree_h) $(GeneFeatures_h) +Results_h = src/ezBAMQC/Resualts.h +Mappability_h = src/ezBAMQC/Mappability.h $(Constants_h) +InnerDist_prof_h = src/ezBAMQC/InnerDist_prof.h $(GeneFeatures_h) +Coverage_prof_h = src/ezBAMQC/Coverage_prof.h $(GeneFeatures_h) +parseBAM_h = src/ezBAMQC/parseBAM.h + + +IntervalTree.o: src/ezBAMQC/IntervalTree.cpp $(IntervalTree_h) +GeneFeatures.o: src/ezBAMQC/GeneFeatures.cpp $(GeneFeatures_h) +rRNA.o: src/ezBAMQC/rRNA.cpp $(rRNA_h) +Results.o: src/ezBAMQC/Results.cpp $(Results_h) +Mappability.o: src/ezBAMQC/Mappability.cpp $(Mappability_h) $(htslib_sam_h) +InnerDist_prof.o: src/ezBAMQC/InnerDist_prof.cpp $(InnerDist_prof_h) $(htslib_sam_h) +Coverage_prof.o: src/ezBAMQC/Coverage_prof.cpp $(Coverage_prof_h) +parseBAM.o: src/ezBAMQC/parseBAM.cpp $(parseBAM_h) $(htslib_sam_h) $(GeneFeatures_h) $(rRNA_h) $(Mappability_h) $(Coverage_prof_h) $(InnerDist_prof_h) + + +#install: $(PROGRAMS) $(BUILT_MISC_PROGRAMS) +# $(INSTALL_DIR) $(DESTDIR)$(bindir) $(DESTDIR)$(man1dir) +# $(INSTALL_PROGRAM) $(PROGRAMS) $(MISC_PROGRAMS) $(DESTDIR)$(bindir) +# $(INSTALL_DATA) samtools.1 $(DESTDIR)$(man1dir) + + +mostlyclean: + -rm -f src/*.o + +clean: mostlyclean + -rm -f $(PROGRAMS) + +distclean: clean + -rm -f TAGS + +clean-all: clean + + +tags: + ctags -f TAGS *.[ch] misc/*.[ch] + + +force: + + +.PHONY: all clean clean-all distclean force +.PHONY: mostlyclean tags
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/README.rst Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,184 @@ +.. image:: https://raw.githubusercontent.com/mhammell-laboratory/bamqc/master/doc/bamqc-icon.png + :width: 200 px + :alt: generated at codeology.braintreepayments.com/mhammell-laboratory/bamqc + :align: right + :target: http://codeology.braintreepayments.com/mhammell-laboratory/bamqc + +===== +ezBAMQC +===== +*"ezBAMQC, a tool to check the quality of mapped next generation sequencing files."* + +:Description: + + ezBAMQC is a tool to check the quality of either one or many mapped next-generation-sequencing datasets. It conducts comprehensive evaluations of aligned sequencing data from multiple aspects including: clipping profile, mapping quality distribution, mapped read length distribution, genomic/transcriptomic mapping distribution, inner distance distribution (for paired-end reads), ribosomal RNA contamination, transcript 5’ and 3’ end bias, transcription dropout rate, sample correlations, sample reproducibility, sample variations. It outputs a set of tables and plots and one HTML page that contains a summary of the results. Many metrics are designed for RNA-seq data specifically, but ezBAMQC can be applied to any mapped sequencing dataset such as RNA-seq, CLIP-seq, GRO-seq, ChIP-seq, DNA-seq and so on. :: + +:Links: + + `Github Page <https://github.com/mhammell-laboratory/bamqc>`_ + + `Pypi Page <https://pypi.python.org/pypi/ezBAMQC>`_ + + `MHammell Lab <http://hammelllab.labsites.cshl.edu/software>`_ + +:Authors: + Ying Jin, David Molik, and Molly Hammell + +:Version: 0.6.5 + +:Contact: + Ying Jin (yjin@cshl.edu) + +Installation guide for ezBAMQC for from source installs +===================================================== + +When installing ezBAMQC there are several options, but the main point is: since ezBAMQC uses C++ STD 11 you'll need a version of GCC that can support that, this useally means 4.8 or 4.9. beyond that, you'll need Python, R and Corrplot for interfacing with the C code. + +:Intallation: + `Source Code <https://github.com/mhammell-laboratory/ezBAMQC/releases>`_ + + `Pypi <https://pypi.python.org/pypi?:action=display&name=ezBAMQC>`_ + +:Prerequisites: + * `python2.7 <https://www.python.org/download/releases/2.7/>`_ + * `R <https://www.r-project.org/>`_ + * `corrplot <https://cran.r-project.org/web/packages/corrplot/>`_ + * `GCC 4.8.1 or greater <https://gcc.gnu.org/gcc-4.8/>`_ GCC 4.9.1 or greater is recomended for PyPi install + +:Notes: + * While there are multiple methods of installing the prerequistes it may help to look at (if using a yum based linux distro):* + * `Devtoolset-3 <https://access.redhat.com/documentation/en-US/Red_Hat_Developer_Toolset/3/html/User_Guide/sect-Red_Hat_Developer_Toolset-Install.html>`_ for GCC compilers + * `IUS <https://ius.io/>`_ for Python2.7 + * `Software Collections <https://www.softwarecollections.org/>`_ for collections of software (like devtoolset 3 or python) + * `rpmfinder <https://www.rpmfind.net/>`_ for searching rpms across mutliple systems + +Setup +===== + +1) Make sure that the GCC comiler is in your PATH: + +:: + + export PATH=/path/to/gcc:$PATH + +2) Make sure that python2.7 is in your PYTHONPATH: + +:: + + export PYTHONPATH=/path/to/python2.7/site-packages:$PYTHONPATH + +3) There are three methods of installation of ezBAMQC, from source, from setup.py, and from pypi, once prequistes are setup. + +From Source +~~~~~~~~~~~ + +1) Download source + +2) Unpack tarball and go to the directory of the package: + +:: + + tar xvfz bamqc-0.6.6.tar.gz + + cd bamqc-0.6.6 + +3) Run make: + +:: + + make + +From Setup.py +~~~~~~~~~~~~~ + +:: + + python2.7 setup.py install + +From Pypi +~~~~~~~~~ + +:: + + pip2.7 install BAMqc + +Usage +===== + +:: + + ezBAMQC [-h] -i alignment_files [alignment_files ...] -r [refgene] + [-f [attrID]] [--rRNA [rRNA]] -o [dir] [--stranded [stranded]] + [-q [mapq]] [-l labels [labels ...]] [-t NUMTHREADS] + +optional arguments: + +:: + + -h, --help show this help message and exit. + -i, --inputFile alignment files. Could be multiple SAM/BAM files separated by space. Required. + -r, --refgene gene annotation file in GTF format. Required + -f the read summation at which feature level in the GTF file. DEFAULT: gene_id. + --rRNA rRNA coordinates in BED format. + -o, --outputDir output directory. Required. + --stranded strandness of the library? + yes : sense stranded + reverse : reverse stranded + no : not stranded + DEFAULT: yes. + -q, --mapq Minimum mapping quality (phred scaled) for an alignment to be called uniquely mapped. DEFAULT:30 + -l, --label Labels of input files. DEFAULT:smp1 smp2 ... + -t, --threads Number of threads to use. DEFAULT:1 + +Example: + +:: + + ezBAMQC -i test-data/exp_data/treat1.bam test-data/exp_data/treat2.bam test-data/exp_data/treat3.bam -r test-data/exp_data/hg9_refGene.gtf -q 30 --rRNA test-data/exp_data/hg19_rRNA.bed -o exp_output2 + + Please find the example output from folder test-data. + +FAQ +==== +Q: Why use ezBAMQC? + +A: ezBAMQC is efficient and easy to use. With one command line, it reports a comprehensive evaluation of the data with a set of plots and tables.The ability to assess multiple samples together with high efficiency make it especially useful in cases where there are a large number of samples from the same condition, genotype, or treatment. ezBAMQC was written in C++ and supports multithreading. A mouse RNA-seq sample with 120M alignments can be done in 8 minutes with 5 threads. + +Q: Why the total number of reads reported by ezBAMQC does not match with samtools flagstat? + +A: The difference is because of non-uniquely mapped reads or multiply aligned reads (multi-reads). Samtools flagstat counts each multiple aligment as a different reads, but ezBAMQC counts reads accoriding to the read ID, i.e., each individual read will be counted once no matter that it is a uniquely mapped read or multi-read. + +Q: What is "Low Quality Reads" ? + +A: Reads marked as qc fail accoriding to SAM format or reads with mapping quality lower than the value set by the option -q will be considered as "Low Quality Reads". + +Q: How the setting of option -q alter the results? + +A: Reads with low quality, i.e., did not pass -q cutoff, are only counted in Total Reads, Mapped Reads, and Mappability by mapping quality plot. The rest of the report does not include low quality reads. + +Q: Do multi-reads (non-uniquely mapped reads) have been considered in Read distribution and gene quantification? + +A: No. Only uniquely mapped reads were counted. + + +Acknowledgements +================ + +#) Samtools contributors +#) Users' valuable feedback + +Copying & Distribution +====================== + +ezBAMQC is free software: you can redistribute it and/or modify +it under the terms of the GNU General Public License as published by +the Free Software Foundation, either version 3 of the License, or +(at your option) any later version. + +This program is distributed in the hope that it will be useful, +but *WITHOUT ANY WARRANTY*; without even the implied warranty of +*MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE*. See the +GNU General Public License for more details. + +You should have received a copy of the GNU General Public License +along with ezBAMQC. If not, see `this website <http://www.gnu.org/licenses/>`_
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/doc/CONTACTS Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1 @@ +Ying Jin: yjin@cshl.edu
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/doc/COPYING Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,619 @@ + GNU GENERAL PUBLIC LICENSE + Version 3, 29 June 2007 + + Copyright (C) 2007 Free Software Foundation, Inc. <http://fsf.org/> + Everyone is permitted to copy and distribute verbatim copies + of this license document, but changing it is not allowed. + + Preamble + + The GNU General Public License is a free, copyleft license for +software and other kinds of works. + + The licenses for most software and other practical works are designed +to take away your freedom to share and change the works. By contrast, +the GNU General Public License is intended to guarantee your freedom to +share and change all versions of a program--to make sure it remains free +software for all its users. We, the Free Software Foundation, use the +GNU General Public License for most of our software; it applies also to +any other work released this way by its authors. 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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/doc/INSTALL Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,74 @@ + +Installation guide for ezBAMQC for from source installs +===================================================== + +When installing ezBAMQC there are several options, but the main point is: since ezBAMQC uses C++ STD 11 you'll need a version of GCC that can support that, this useally means 4.8 or 4.9. beyond that, you'll need Python, R and Corrplot for interfacing with the C code. + +:Intallation: + `Source Code <https://github.com/mhammell-laboratory/bamqc/archive/0.6.4.tar.gz>`_ + + `Pypi <https://pypi.python.org/pypi?:action=display&name=BAMQC&version=0.6.4>`_ + +:Prerequisites: + * `python2.7 <https://www.python.org/download/releases/2.7/>`_ + * `R <https://www.r-project.org/>`_ + * `corrplot <https://cran.r-project.org/web/packages/corrplot/>`_ + * `GCC 4.8.1 or greater <https://gcc.gnu.org/gcc-4.8/>`_ GCC 4.9.1 or greater is recomended for PyPi install + +:Notes: + * While there are multiple methods of installing the prerequistes it may help to look at (if using a yum based linux distro):* + * `Devtoolset-3 <https://access.redhat.com/documentation/en-US/Red_Hat_Developer_Toolset/3/html/User_Guide/sect-Red_Hat_Developer_Toolset-Install.html>`_ for GCC compilers + * `IUS <https://ius.io/>`_ for Python2.7 + * `Software Collections <https://www.softwarecollections.org/>`_ for collections of software (like devtoolset 3 or python) + * `rpmfinder <https://www.rpmfind.net/>`_ for searching rpms across mutliple systems + +Setup +===== + +1) Make sure that the GCC comiler is in your PATH: + +:: + + export PATH=/path/to/gcc:$PATH + +2) Make sure that python2.7 is in your PYTHONPATH: + +:: + + export PYTHONPATH=/path/to/python2.7/site-packages:$PYTHONPATH + +3) There are three methods of installation of ezBAMQC, from source, from setup.py, and from pypi, once prequistes are setup. + +From Source +~~~~~~~~~~~ + +1) Download source + +2) Unpack tarball and go to the directory of the package: + +:: + + tar xvfz bamqc-0.6.4.tar.gz + + cd bamqc-0.6.4 + +3) Run make: + +:: + + make + +From Setup.py +~~~~~~~~~~~~~ + +:: + + python2.7 setup.py install + +From Pypi +~~~~~~~~~ + +:: + + pip2.7 install BAMqc +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/doc/THANKS Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3 @@ +Acknowledgements goes to: +1) Samtools contributors +4) Users' valuable feedback
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/ezBAMQC Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1832 @@ +#!/usr/bin/env python2.7 + +''' + +Created on July 24, 2015 + + + +@author: Ying Jin + +@contact: yjin@cshl.edu + +@status: + +@version: 0.6.6 + +''' + +import argparse, subprocess,traceback + +import sys, os, time, string, re + +import warnings, logging + +import collections + +import math, copy + +import sets + +from time import strftime + +from datetime import datetime + +import ctypes + +import multiprocessing,threading,Queue + + + +def locate(name, path): + + for root, dirs, files in os.walk(path): + + if name in files: + + return os.path.join(root, name) + + + +def locBAMqc(loc): + + for p in os.environ[loc].split(os.pathsep): + + potential_file = locate('libBAMqc.so',p) + + if potential_file: + + return potential_file + + + +in_path = locBAMqc('PATH') + +in_pythonpath = locBAMqc('PYTHONPATH') + +in_local = locate('libBAMqc.so','./') + + + +if in_local: + + so=ctypes.CDLL(in_local) + +elif in_path: + + so=ctypes.CDLL(in_path) + +elif in_pythonpath: + + so=ctypes.CDLL(in_pythonpath) + +else: + + print "can not find libBAMqc.so, you're not setup correctly, exiting\n" + + sys.exit() + + + +if sys.version_info[0] != 2 or sys.version_info[1] != 7: + + print >>sys.stderr, "\nYou are using python" + str(sys.version_info[0]) + '.' + str(sys.version_info[1]) + " ezBAMQC needs python2.7!\n" + + sys.exit() + + + + + +class pyResults : + + + + def __init__(self): + + self.filename = "" + + self.is_pairEnd = False + + self.clipping_plot_file = "" + + self.mapq_plot_file = "" + + self.mapq_file = "" + + self.read_cov_plot_file = "" + + self.trans_cov_plot_file = "" + + self.insert_plot_file = "" + + self.insert_file = "" + + self.read_dist_plot_file1 = "" + + self.read_dist_plot_file2 = "" + + self.read_dup_plot_file = "" + + self.readLen_plot_file = "" + + self.geneCount_file = "" + + + + self.seqDeDup_percent = 0 + + self.posDeDup_percent = 0 + + + + self.no_clipping = False + + self.no_rRNA = False + + + + + + self.total_reads = 0 + + self.uniq_mapped_reads = 0 + + self.multi_mapped_reads = 0 + + self.unmapped_reads = 0 + + self.low_qual = 0 + + self.low_qual_read1 = 0 + + self.low_qual_read2 = 0 + + self.pcr_dup = 0 + + + + self.unmapped_read1 = 0 + + self.unmapped_read2 = 0 + + self.mapped_read1 = 0 + + self.mapped_read2 = 0 + + self.forward_read = 0 + + self.reverse_read = 0 + + self.paired_reads = 0 + + + + self.mapped_plus_minus = 0 + + self.mapped_plus_plus = 0 + + self.mapped_minus_plus = 0 + + self.mapped_minus_minus = 0 + + + + self.ins_read = 0 + + self.del_read = 0 + + + + self.noSplice = 0 + + self.splice = 0 + + self.paired_diff_chrom = 0 + + + + self.rRNA_read = 0 + + self.intron_read = 0 + + self.cds_exon_read = 0 + + self.utr_5_read = 0 + + self.utr_3_read = 0 + + self.intergenic_up1kb_read = 0 + + self.intergenic_down1kb_read = 0 + + self.intergenic_read = 0 + + + + + +def read_in_res(cur_data_dir,label): + + res = pyResults() + + fname = cur_data_dir+label+'.res.txt' + + + + try : + + if os.path.exists(fname) : + + f = open(fname,'r') + + for line in f : + + line = line.strip() + + (name,value) = line.split('\t') + + if name == "rRNA_read" : + + res.rRNA_read = int(value) + + if name == "low_qual_read1" : + + res.low_qual_read1 = int(value) + + if name == "low_qual_read2" : + + res.low_qual_read2 = int(value) + + if name == "filename" : + + res.filename = value + + if name == "is_pairEnd" : + + res.is_pairEnd = True if int(value) == 1 else False + + if name == "clipping_plot_file" : + + res.clipping_plot_file = value + + if name == "mapq_plot_file" : + + res.mapq_plot_file = value + + if name == "mapq_file" : + + res.mapq_file = value + + if name == "read_cov_plot_file": + + res.read_cov_plot_file = value + + if name == "trans_cov_plot_file": + + res.trans_cov_plot_file = value + + if name == "insert_plot_file" : + + res.insert_plot_file = value + + if name == "insert_file" : + + res.insert_file = value + + if name == "read_dist_plot_file1" : + + res.read_dist_plot_file1 = value + + if name == "read_dist_plot_file2" : + + res.read_dist_plot_file2 = value + + if name == "read_dup_plot_file" : + + res.read_dup_plot_file = value + + if name == "readLen_plot_file" : + + res.readLen_plot_file = value + + if name == "geneCount_file" : + + res.geneCount_file = value + + if name == "seqDeDup_percent" : + + res.seqDeDup_percent = float(value) + + if name == "posDeDup_percent" : + + res.posDeDup_percent = float(value) + + if name == "no_clipping" : + + res.no_clipping = False if int(value) == 0 else True + + if name == "no_rRNA" : + + res.no_rRNA = False if int(value) == 0 else True + + if name == "total_reads" : + + res.total_reads = int(value) + + if name == "uniq_mapped_reads" : + + res.uniq_mapped_reads = int(value) + + if name == "multi_mapped_reads" : + + res.multi_mapped_reads = int(value) + + if name == "unmapped_reads" : + + res.unmapped_reads = int(value) + + if name =="low_qual" : + + res.low_qual = int(value) + + if name == "pcr_dup" : + + res.pcr_dup = int(value) + + if name == "unmapped_read1" : + + res.unmapped_read1 = int(value) + + if name == "unmapped_read2" : + + res.unmapped_read2 = int(value) + + if name =="mapped_read1": + + res.mapped_read1 = int(value) + + if name =="mapped_read2": + + res.mapped_read2 = int(value) + + if name =="forward_read": + + res.forward_read = int(value) + + if name =="reverse_read" : + + res.reverse_read = int(value) + + if name =="paired_reads": + + res.paired_reads = int(value) + + if name =="mapped_plus_minus": + + res.mapped_plus_minus = int(value) + + if name =="mapped_plus_plus": + + res.mapped_plus_plus = int(value) + + if name == "mapped_minus_plus" : + + res.mapped_minus_plus = int(value) + + if name =="mapped_minus_minus" : + + res.mapped_minus_minus = int(value) + + if name =="ins_read" : + + res.ins_read = int(value) + + if name == "del_read" : + + res.del_read = int(value) + + if name == "noSplice" : + + res.noSplice = int(value) + + if name =="splice": + + res.splice = int(value) + + if name =="paired_diff_chrom" : + + res.paired_diff_chrom = int(value) + + f.close() + + #os.remove(fname) + + else : + + sys.stderr.write("output file does not exist for sample %s\n" % (label)) + + except : + + sys.stderr.write("Error in reading output.\n") + + sys.exit(1) + + return res + + + + + + + +def worker(in_queue,out_queue) : + + #for (label,fname,param) in iter(in_queue.get,'STOP'): + + (fname,label,cur_data_dir,cur_fig_dir,rRNA_model,ref_gene_model,attrID,mapq,stranded) = in_queue.get() + + if fname is not None : + + ret = so.run_qc(cur_data_dir,cur_fig_dir,ref_gene_model,attrID,fname,rRNA_model,label,mapq,stranded) + + if ret == 1 : + + res = read_in_res(cur_data_dir,label) + + create_per_sample_plot(fname,label,cur_data_dir,cur_fig_dir,res) + + out_queue.put((label,res)) + + + + + + + + + +def distr_jobs2(args,cur_data_dir,cur_fig_dir): + + + + smp_res = dict() + + try: + + #mgr = multiprocessing.Manager() + + #param = [cur_data_dir,cur_fig_dir,args.mapq,args.stranded] + + if args.numProc <= len(args.ifiles) : + + num_process = args.numProc + + else : + + num_process = len(args.ifiles) + + + + processed = 0 + + while processed < len(args.ifiles) : + + task_queue = multiprocessing.Queue() + + result_queue = multiprocessing.Queue() + + + + if processed + num_process > len(args.ifiles) : + + num_process = len(args.ifiles) - processed + + + + for i in range(processed,processed+num_process) : + + label = args.labels[i] + + fname = args.ifiles[i] + + t = ((fname,label,cur_data_dir,cur_fig_dir,args.rRNA_model,args.ref_gene_model,args.attrID,args.mapq,args.stranded)) + + task_queue.put(t) + + + + procs = [] + + for i in range(num_process) : + + p = multiprocessing.Process(target=worker,args=(task_queue,result_queue)) + + #p.daemon=True + + p.start() + + procs.append(p) + + #task_queue.put('STOP') + + finished = 0 + + for p in procs : + + p.join() + + #sys.stderr.write(str(p.exitcode)+"\n") + + if p.exitcode != 0 : + + sys.stderr.write("subprocess error %s " % (p.exitcode)) + + sys.exit(1) + + if p.exitcode == 0 : + + finished += 1 + + processed += 1 + + if finished == len(procs) : + + break + + + + for i in range(num_process) : + + (label,res) = result_queue.get() + + smp_res[label] = res + + + + except: + + sys.stderr.write("Error: %s\n" % str(sys.exc_info()[1])) + + sys.stderr.write( "[Exception type: %s, raised in %s:%d]\n" % + + ( sys.exc_info()[1].__class__.__name__, + + os.path.basename(traceback.extract_tb( sys.exc_info()[2] )[-1][0]), + + traceback.extract_tb( sys.exc_info()[2] )[-1][1] ) ) + + sys.exit(1) + + + + return smp_res + + + + + + + +def main(): + + + + #read in options + + args = read_opts(prepare_parser()) + + + + info = args.info + + warn = args.warn + + debug = args.debug + + error = args.error + + crit = args.critical + + #local_rRNAIdx = None + + #local_geneIdx = None + + + + info("*** Starting BAMqc run. ***\n") + + + + #list of qc results + + smp_res = dict() + + + + #working directory and output files + + cur_dir = os.path.abspath(args.dir) + + cur_base_dir = os.path.basename(args.dir) + + cur_fig_dir = cur_dir+"/figs/" + + cur_data_dir = cur_dir + "/data/" + + data_file = cur_dir+"summary_data.txt" + + html_file = cur_dir+"/ezBAMQC_output.html" + + + + #check folders and files + + try : + + if os.path.exists(cur_dir) : + + error("Folder already exists!\n") + + sys.exit(1) + + if not os.path.exists(cur_dir) : + + os.makedirs(cur_dir) + + if not os.path.exists(cur_fig_dir): + + os.makedirs(cur_fig_dir) + + if not os.path.exists(cur_data_dir): + + os.makedirs(cur_data_dir) + + + + except : + + error("Error in create output folder.\n") + + sys.exit(1) + + + + if args.numProc >=2 : + + smp_res = distr_jobs2(args,cur_data_dir,cur_fig_dir) + + else : + + for i in range(len(args.ifiles)) : + + ifile = args.ifiles[i] + + + + ret = so.run_qc(cur_data_dir,cur_fig_dir,args.ref_gene_model,args.attrID,ifile,args.rRNA_model,args.labels[i],args.mapq,args.stranded,args.numThreads) + + if ret == 1 : + + res = read_in_res(cur_data_dir,args.labels[i]) + + create_per_sample_plot(ifile,args.labels[i],cur_data_dir,cur_fig_dir,res) + + smp_res[args.labels[i]] = res + + + + #sample correlation + + smp_corr_plot_file = cur_fig_dir+"smp_corr.png" + + smp_repro_plot_file = cur_fig_dir+"smp_reproducibility.png" + + smp_var_plot_file = cur_fig_dir+"smp_var.png" + + smp_inner_plot_file = cur_fig_dir+"smp_inner_dist.png" + + smp_cov_plot_file = cur_fig_dir+"smp_cov.png" + + smp_quality_plot_file = cur_fig_dir+"smp_qual.png" + + #smp_dup_plot_file = cur_fig_dir+"smp_dup.png" + + #smp_summary_file = cur_data_dir +"smp_summary.txt" + + + + if len(smp_res) > 1 : + + + + smp_cnt = 0 + + header_corr = 'c(' + + header_insert = 'c(' + + header_mapq = 'c(' + + #header_dup = 'c(' + + #sys.stderr.write(','.join(smp_res.values()+"\n")) + + + + filenames_corr = 'c(' + + filenames_insert = 'c(' + + filenames_mapq = 'c(' + + #filenames_dup_seq = 'c(' + + #filenames_dup_pos = 'c(' + + pe_smp_cnt = 0 + + for k in range(len(args.labels)) : + + key = args.labels[k] + + if not smp_res[key].mapq_file == "" : + + filenames_mapq += '"' + cur_base_dir+ "/data/" + os.path.basename(smp_res[key].mapq_file) + '",' + + header_mapq += '"'+key+'",' + + + + if not smp_res[key].insert_file == "" and smp_res[key].is_pairEnd: + + pe_smp_cnt += 1 + + filenames_insert += '"' + cur_base_dir + "/data/"+os.path.basename(smp_res[key].insert_file) + '",' + + header_insert += '"'+key+'",' + + + + if not smp_res[key].geneCount_file == "" : + + smp_cnt += 1 + + filenames_corr += '"' + cur_base_dir + "/data/"+ os.path.basename(smp_res[key].geneCount_file) + '",' + + header_corr += '"'+key+'",' + + + + header_corr = header_corr[0:len(header_corr)-1] + ')' + + filenames_corr = filenames_corr[0:len(filenames_corr)-1] + ')' + + filenames_insert = filenames_insert[0:len(filenames_insert)-1] + ')' + + header_insert = header_insert[0:len(header_insert)-1] + ')' + + + + header_mapq = header_mapq[0:len(header_mapq)-1] + ')' + + filenames_mapq = filenames_mapq[0:len(filenames_mapq)-1] + ')' + + #header_dup = header_dup[0:len(header_dup)-1] + ')' + + #filenames_dup_seq = filenames_dup_seq[0:len(filenames_dup_seq)-1] + ')' + + #filenames_dup_pos = filenames_dup_pos[0:len(filenames_dup_pos)-1] + ')' + + + + if smp_cnt > 1 : + + info("*** Sample Correlation ***") + + try : + + #subprocess.call(cmd_str+" >"+smp_summary_file, shell=True) + + + + smp_corr_r = cur_data_dir+"smp_correlation.r" + + + + f = open(smp_corr_r,'w') + + f.write("library(corrplot)\n") + + f.write('srcfiles = '+filenames_corr+'\n') + + f.write('destfile = "'+smp_corr_plot_file+'"\n') + + f.write('f1 = read.delim(srcfiles[1],header=T)\n') + + f.write('MM=matrix(nrow=length(f1[,1]),ncol=length(srcfiles))\n') + + f.write('rownames(MM)=f1[,1]\n') + + f.write('MM[,1]=f1[,2]\n') + + f.write('for (i in 2:length(srcfiles)){ \n') + + f.write(' f = read.delim(srcfiles[i],header=T)\n') + + f.write(' MM[,i] = f[,2] }\n') + + f.write('colnames(MM)='+header_corr+'\n') + + f.write('libSize<-colSums(MM)\n') + + f.write('MM<-t(t(MM)*1000000/libSize)\n') + + f.write('ss<-rowSums(MM)\n') + + f.write('M1<-MM[ss>0,]\n') + + f.write('MM_s<-t(scale(t(M1)))\n') + + f.write("M.cor<-cor(MM_s,method='sp')\n") + + f.write("M.cor[is.na(M.cor)]<- 0\n") + + f.write("png(destfile,width=500,height=500,units='px')\n") + + f.write("corrplot(M.cor,is.corr=T,order='FPC',method='color',type='full',add=F,diag=T)\n") + + f.write("dev.state = dev.off()\n") + + f.write("nz_genes = length(M1[,1])\n") + + f.write('destfile = "'+smp_repro_plot_file+'"\n') + + f.write("if(nz_genes >0) { \n") + + f.write("png(destfile,width=500,height=500,units='px')\n") + + f.write("nz_gene_mm = rep(0,length(M1[1,]))\n") + + f.write("for(i in 1:length(M1[1,])) { \n") + + f.write("nz_gene_mm[i] = length(which(M1[,i]>0))/nz_genes * 100 } \n") + + f.write("bplt <- barplot(nz_gene_mm,beside=T,border='NA',space=1.5,ylim=c(0,100),ylab='Genes reproducibly detected (%)',col='blue',names.arg=colnames(MM))\n") + + f.write("text(y= nz_gene_mm+2, x= bplt, labels=paste(as.character(round(nz_gene_mm,digits=1)),'%',sep=''), xpd=TRUE)\n") + + f.write("dev.state = dev.off()}\n") + + + + f.write('destfile = "'+smp_var_plot_file+'"\n') + + f.write("png(destfile,width=500,height=500,units='px')\n") + + f.write("mad = rep(0,length(M1[,1]))\n") + + f.write("nz_gene_median = rep(0,length(M1[,1]))\n") + + f.write("for(i in 1:length(M1[,1])) { \n") + + f.write("nz_gene_median[i] = median(M1[i,]) \n") + + f.write("mad[i] = median(abs(M1[i,]-nz_gene_median[i])) } \n") + + f.write("mad2 = mad[nz_gene_median >0] \n") + + f.write("nz_gene_median2 = nz_gene_median[nz_gene_median>0] \n") + + f.write("mad_vs_median = mad2/nz_gene_median2 \n") + + f.write("nz_gene_median3 = log(nz_gene_median2, base=2)\n") + + f.write("dd<-data.frame(nz_gene_median3,mad_vs_median) \n") + + f.write("x = densCols(nz_gene_median3,mad_vs_median, colramp=colorRampPalette(c('black', 'white')))\n") + + f.write("dd$dens <- col2rgb(x)[1,] + 1L \n") + + f.write('cols <- colorRampPalette(c("#000099", "#00FEFF", "#45FE4F", "#FCFF00", "#FF9400", "#FF3100"))(256)\n') + + f.write('dd$col <- cols[dd$dens]\n') + + f.write('plot(mad_vs_median ~ nz_gene_median3,data=dd[order(dd$dens),], col=col, pch=20,xlab="Gene expression (median RPM log2)",ylab="Median absolute deviation/median")\n') + + f.write('dev.state = dev.off()\n') + + + + #f.write('destfile = "'+smp_corr_plot_file2+'"\n') + + #f.write("M.pc<-prcomp(t(MM_s))\n") + + #f.write("png(destfile,width=500,height=500,units='px')\n") + + #f.write("plot(M.pc)\n") + + #f.write("dev.state = dev.off()\n") + + + + f.write('destfile = "'+smp_cov_plot_file+'"\n') + + f.write("png(destfile,width=500,height=500,units='px')\n") + + f.write('xname=c("<0.5","0.5-10","10-100",">=100")\n') + + f.write('Fn_mm = matrix(0,nrow=length(xname),ncol=length(M1[1,]))\n') + + f.write('rownames(Fn_mm) = xname \n') + + f.write('colnames(Fn_mm) = ' + header_corr + ' \n') + + + + f.write('for(i in 1:length(M1[1,])) { \n') + + f.write('Fn_mm[1,i] = length(which(M1[,i]<0.5)) \n') + + f.write('Fn_mm[2,i] = length(which(M1[,i]>=0.5 & M1[,i]<10))\n') + + f.write('Fn_mm[3,i] = length(which(M1[,i]>=10 & M1[,i]<100))\n') + + f.write('Fn_mm[4,i] = length(which(M1[,i]>=100)) }\n') + + + + f.write('barplot(Fn_mm,main="Gene abundance (RPM)",xlab="Sample",ylab="Frequency",col=c("green","blue","red","yellow"),legend=xname)\n') + + f.write("dev.state = dev.off()\n") + + if pe_smp_cnt > 0 : + + f.write('srcfiles2 = '+filenames_insert+'\n') + + f.write('destfile2 = "'+smp_inner_plot_file+'"\n') + + f.write("png(destfile2,width=500,height=500,units='px')\n") + + f.write('f = read.delim(srcfiles2[1],header=T)\n') + + f.write('freq=rep(round((f[,1]+f[,2]+1)/2,0),times=f[,3])\n') + + f.write('smp ='+header_insert+'\n') + + f.write('boxplot(freq,outline=F,xlim=c(0,length(smp)+1),ylab="Inner distance (bp)",col="blue",border="black") \n') + + f.write('for (i in 2:length(srcfiles2)){ \n') + + f.write(' f = read.delim(srcfiles2[i],header=T)\n') + + f.write('freq=rep(round((f[,1]+f[,2]+1)/2,0),times=f[,3])\n') + + f.write('boxplot(freq,add=T,outline=F,at=i,col="blue",border="black") }\n') + + f.write('axis(1,at=seq(1,length(smp),by=1),labels=smp,las=2)\n') + + f.write("dev.state = dev.off()\n") + + + + f.write('destfile3 = "'+smp_quality_plot_file+'"\n') + + f.write('srcfiles3 = '+filenames_mapq+'\n') + + f.write("png(destfile3,width=500,height=500,units='px')\n") + + f.write('xname=c("<3","3-10","10-20","20-30",">=30")\n') + + f.write('Fn_mm = matrix(0,nrow=length(xname),ncol=length(srcfiles3))\n') + + f.write('rownames(Fn_mm) = xname \n') + + f.write('colnames(Fn_mm) = ' + header_mapq + ' \n') + + + + f.write('for(i in 1:length(srcfiles3)) { \n') + + f.write(' f = read.delim(srcfiles3[i],header=T)\n') + + f.write(' if(length(which(f[,1]<3)) >0){ Fn_mm[1,i] = sum(f[which(f[,1]<3),3])/f[1,2]} \n') + + f.write('if(length(which(f[,1]>=3 & f[,1]<10)) >0) {Fn_mm[2,i] = sum(f[which(f[,1]<10 & f[,1]>=3),3])/f[1,2]} \n') + + f.write('if(length(which(f[,1]>=10 & f[,1]<20)) >0) {Fn_mm[3,i] = sum(f[which(f[,1]<20 & f[,1]>=10),3])/f[1,2] }\n') + + f.write('if(length(which(f[,1]>=20 & f[,1]<30)) >0) {Fn_mm[4,i] = sum(f[which(f[,1]<30 & f[,1]>=20),3])/f[1,2]} \n') + + f.write('if(length(which(f[,1]>=30)) >0) {Fn_mm[5,i] = sum(f[which(f[,1]>=30),3])/f[1,2] }} \n') + + + + f.write('barplot(Fn_mm,xlab="Sample",main="Mapping Quality",ylim=c(0,1),ylab="Frequency",col=c("blue","green","yellow","orange","red"),legend=xname)\n') + + f.write("dev.state = dev.off()\n") + + + + #f.write('destfile3 = "'+smp_dup_plot_file+'"\n') + + #f.write('srcfiles3 = '+filenames_dup_pos+'\n') + + #f.write('srcfiles4 = '+filenames_dup_seq+'\n') + + #f.write('png(destfile3,width=500,height=500,units="px")\n') + + #f.write('M = matrix(0,nrow=2,ncol=length(srcfiles3))\n') + + #f.write('colnames(M) = ' + header_dup + ' \n') + + + + #f.write('for(i in 1:length(srcfiles3)) { \n') + + #f.write('f_pos = read.delim(srcfiles3[i],header=T) \n') + + #f.write('f_seq = read.delim(srcfiles4[i],header=T) \n') + + #f.write('total = sum(f_pos[,1]*f_pos[,2]) \n') + + #f.write('pos_dedup = round(sum(f_pos[,2])/total*100,2) \n') + + #f.write('seq_dedup = round(sum(f_seq[,2])/total*100,2) \n') + + #f.write('M[1,i] = pos_dedup \n') + + #f.write('M[2,i] = seq_dedup }\n') + + + + #f.write('rownames(M)<-c("Position","Sequence")\n') + + #f.write('barplot(M,ylim=c(0,100),beside=T,col=c("blue","red"),main="Duplication",xlab="Sample",ylab="Percentage after deduplication",legend=c("Mapping position","Sequence"),args.legend=list(bty="n"))\n') + + #f.write('dev.state = dev.off()\n') + + + + + + + + f.close() + + + + subprocess.call("Rscript " + smp_corr_r , shell=True) + + + + except: + + sys.stderr.write("Error in computing sample correlation.\n") + + smp_corr_plot_file = "" + + smp_corr_plot_file2 = "" + + pass + + + + info("*** Correlation completed ***\n") + + + + #outputToHTML(smp_res,args.labels,smp_corr_plot_file,smp_inner_plot_file, smp_quality_plot_file,smp_cov_plot_file,html_file) + + outputToHTML(smp_res,args.labels,html_file) + + info("*** BAM QC run completed. ***\n") + + + + + +def create_per_sample_plot(ifile,label,cur_data_dir,cur_fig_dir,res): + + output_prefix_data = cur_data_dir + label + + output_prefix_fig = cur_fig_dir + label + + try: + + subprocess.call("Rscript "+output_prefix_data+'.read_distr.r',shell=True) + + except : + + print("Error in plotting read distributions.\n") + + res.read_dist_plot_file1 = "" + + pass + + try: + + subprocess.call("Rscript "+output_prefix_data+'.read_distr_pie.r',shell=True) + + except : + + print("Error in plotting read distributions.\n") + + res.read_dist_plot_file2 = "" + + pass + + + + #res.filename = ifile + + if os.path.isfile(output_prefix_data+'.clipping_profile.r') : + + try: + + subprocess.call("Rscript " + output_prefix_data + '.clipping_profile.r',shell=True) + + # subprocess.call("rm -rf "+ output_prefix + '.clipping_profile.r',shell=True) + + except: + + print("Cannot generate png file form " + output_prefix_data + '.clipping_profile.r\n') + + res.clipping_plot_file = "" + + pass + + else : + + res.no_clipping = True + + + + if os.path.isfile(output_prefix_data+'.mapq_profile.r') : + + try: + + subprocess.call("Rscript " + output_prefix_data + '.mapq_profile.r',shell=True) + + + + except: + + print("Cannot generate png file form " + output_prefix_data + '.mapq_profile.r\n') + + res.mapq_plot_file = "" + + pass + + else : + + res.mapq_plot_file = "" + + if os.path.isfile(output_prefix_data+'.geneBodyCoverage_plot.r') : + + try: + + subprocess.call("Rscript " + output_prefix_data + '.geneBodyCoverage_plot.r',shell=True) + + + + except: + + print("Cannot generate png file from " + output_prefix_data + '.geneBodyCoverage_plot.r\n') + + res.read_cov_plot_file = "" + + pass + + + + try: + + subprocess.call("Rscript " + output_prefix_data + '.TransCoverage.r',shell=True) + + + + except: + + print("Cannot generate png file from " + output_prefix_data + '.TransCoverage.r\n') + + res.trans_cov_plot_file = "" + + pass + + try: + + subprocess.call("Rscript " + output_prefix_data + ".ReadLen_plot.r", shell=True) + + + + except: + + print("Cannot generate png file form " + output_prefix_data + '.ReadLen_plot.rn') + + pass + + if res.is_pairEnd and os.path.isfile(output_prefix_data+'.inner_distance_plot.r') : + + try: + + subprocess.call("Rscript " + output_prefix_data + '.inner_distance_plot.r',shell=True) + + except: + + print("Cannot generate png file form " + output_prefix_data + '.inner_distance_plot.r\n') + + res.insert_plot_file = "" + + pass + + else : + + res.insert_plot_file = "" + + + + + + + +#def outputToHTML(res_list,smps,corr_plot_file,smp_inner_plot_file,smp_quality_plot_file,smp_cov_plot_file,html_file): + +def outputToHTML(res_list,smps,html_file): + + + + #smps = res_list.keys() + + tohtml = '<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Strict//EN">\n' + + tohtml += '<html>\n' + + tohtml += '<head><title>ezBAMQC Report</title>\n' + + tohtml += '<style type="text/css">\n' + + #/*ul Styles*/ + + tohtml += 'html,body{margin:0;padding:0;height:100%;width:1500px}\n' + + tohtml += 'div#header{background-color:#F3F2ED;}\n' + + tohtml += 'div#header h1{text-align:center; height:80px;line-height:80px;margin:0;padding-left:10px;}\n' + + tohtml += 'div#container{text-align:left;height:100%;width:1500px}\n' + + tohtml += 'div#navigation{background:#F6F0E0;}\n' + + tohtml += 'div#navigation{float:left;width:200px;height:100%}\n' + + + + tohtml += '.menu-item ul { \n' + + tohtml += 'background: #F6F0E0; \n' + + tohtml += 'font-size: 13px; \n' + + tohtml += 'line-height: 30px; \n' + + tohtml += 'height: 0px; \n' + + tohtml += 'list-style-type: none;' + + tohtml += 'overflow: hidden; \n' + + tohtml += 'padding: 0px; }\n' + + + + tohtml += '.menu-item:hover ul { height: 220px; }\n ' + + #/* table * + + tohtml += 'table{ margin:0;padding:0;width:1300px;table-layout:fixed;text-align:left; }\n' + + tohtml += 'table > thead > tr.tableizer-firstrow > th { padding: 10px; background: lavenderblush;} \n' + + #/*border: 4px solid #fff;*/ /*text-overflow: ellipsis;*/ /*overflow: hidden;*/ + + tohtml += 'table > tbody > tr > td{ padding: 10px; background: #f8f8f8; word-wrap: break word; } \n' + + tohtml += 'div#footer{background:#BFBD93;}\n' + + tohtml += 'div#footer p{margin:0;padding:5px 10px}\n' + + tohtml += 'div#footer{clear:both;width:100%;text-align:center}\n' + + tohtml += 'div#main{float:right;width:1300px}\n' + + tohtml += 'a{text-decoration:none; color:#000000;}\n' + + tohtml += 'a:hover {text-decoration: underline; }\n' + + + + + + tohtml += '</style> </head>\n' + + tohtml += '<body>\n' + + tohtml += '<div id ="container">\n' + + tohtml += '<div id="header"><h1>ezBAMQC Report</h1><p text-align="left">Created On: '+datetime.now().strftime('%m-%d-%Y')+'</p></div>\n' + + + + i = 0 + + tohtml += '<div id="wrapper">\n' + + tohtml += '<div class="summary" id="navigation">\n' + + #tohtml += '<div id="update_time">\n' + + #tohtml += + + #tohtml += '</div>\n' + + tohtml += '<h2>Summary</h2>\n' + + tohtml += '<ul>\n' + + + + #i = 0 + + for i in range(len(smps)) : + + key = smps[i] + + tohtml += '<li>' + + tohtml += '<div class="menu-item">\n' + + tohtml += '<h4>'+key+'</h4>\n' + + tohtml += '<ul>\n' + + tohtml += '<li><a href="#M'+str(i)+'0">Basic Statistics</a></li>\n' + + tohtml += '<li><a href="#M'+str(i)+'1">Read Distribution</a></li>\n' + + tohtml += '<li><a href="#M'+str(i)+'2">Mappability</a></li>\n' + + tohtml += '<li><a href="#M'+str(i)+'3">Coverage</a></li>\n' + + tohtml += '<li><a href="#M'+str(i)+'4">Read Length and Insertion Size</a></li>\n' + + #tohtml += '<li><a href="#M'+str(i)+'6">rRNA contamination</a></li>\n' + + tohtml += '</ul></div></li>\n' + + #i += 1 + + + + smp_corr_pos = len(smps)*5 + 100 + + + + if len(res_list) > 1: + + tohtml += '<li><div class="menu-item"><a href="#M'+str(smp_corr_pos)+'"><h4>Sample Correlation</h4></a></div></li>\n' + + + + tohtml += '</ul>\n' + + tohtml += '</div>\n' + + + + tohtml += '<div id="main" >\n' + + for i in range(len(smps)): + + key = smps[i] + + res = res_list[key] + + + + tohtml += '<h2>'+key+'</h2>\n' + + tohtml += '<div class="module"><h2 id="M'+str(i)+'0">Basic Statistics</h2>\n' + + tohtml += '<table>\n' + + tohtml += '<thead><tr class=\"tableizer-firstrow\">\n'; + + tohtml += '<th>Measure</th><th>Value</th></tr></thead>\n' + + tohtml += '<tbody><tr><td>Total Reads</td><td>'+str(res.total_reads)+'</td></tr>\n' + + if not res.is_pairEnd : + + tohtml += '<tr><td>Unique Reads</td><td>'+str(res.uniq_mapped_reads)+'</td></tr>\n' + + tohtml += '<tr><td>Multi-reads</td><td>'+str(res.multi_mapped_reads)+'</td></tr>\n' + + tohtml += '<tr><td>Unmapped Reads</td><td>'+str(res.unmapped_reads)+'</td></tr>\n' + + tohtml += '<tr><td>Low Quality Reads</td><td>'+str(res.low_qual)+'</td></tr>\n' + + tohtml += '<tr><td>Forward Reads</td><td>'+str(res.forward_read)+'</td></tr>\n' + + tohtml += '<tr><td>Reverse Reads</td><td>'+str(res.reverse_read)+'</td></tr>\n' + + tohtml += '<tr><td>Splice Reads</td><td>'+str(res.splice)+'</td></tr>\n' + + tohtml += '<tr><td>Non-Splice Reads</td><td>'+str(res.noSplice)+'</td></tr>\n' + + tohtml += '<tr><td>rRNA Reads</td><td>'+str(res.rRNA_read)+'</td></tr></tbody></table></div>\n' + + else : # paired read + + tohtml += '<tr><td>Uniquely Mapped Pairs</td><td>'+str(res.paired_reads)+'</td></tr>\n' + + tohtml += '<tr><td>Uniquely Mapped Read1</td><td>'+str(res.mapped_read1)+'</td></tr>\n' + + tohtml += '<tr><td>Uiquely Mapped Read2</td><td>'+str(res.mapped_read2)+'</td></tr>\n' + + tohtml += '<tr><td>Multi-reads</td><td>'+str(res.multi_mapped_reads)+'</td></tr>\n' + + tohtml += '<tr><td>Unmapped Read1</td><td>'+str(res.unmapped_read1)+'</td></tr>\n' + + tohtml += '<tr><td>Unmapped Read2</td><td>'+str(res.unmapped_read2)+'</td></tr>\n' + + tohtml += '<tr><td>Number of read mapped "+,-" </td><td>'+str(res.mapped_plus_minus)+'</td></tr>\n' + + tohtml += '<tr><td>Number of read mapped "+,+" </td><td>'+str(res.mapped_plus_plus)+'</td></tr>\n' + + tohtml += '<tr><td>Number of read mapped "-,+" </td><td>'+str(res.mapped_minus_plus)+'</td></tr>\n' + + tohtml += '<tr><td>Number of read mapped "-,-" </td><td>'+str(res.mapped_minus_minus)+'</td></tr>\n' + + tohtml += '<tr><td>Low Quality Read1</td><td>'+str(res.low_qual_read1)+'</td></tr>\n' + + tohtml += '<tr><td>Low Quality Read2</td><td>'+str(res.low_qual_read2)+'</td></tr>\n' + + tohtml += '<tr><td>Forward Reads</td><td>'+str(res.forward_read)+'</td></tr>\n' + + tohtml += '<tr><td>Reverse Reads</td><td>'+str(res.reverse_read)+'</td></tr>\n' + + tohtml += '<tr><td>Splice Reads</td><td>'+str(res.splice)+'</td></tr>\n' + + tohtml += '<tr><td>Non-Splice Reads</td><td>'+str(res.noSplice)+'</td></tr>\n' + + tohtml += '<tr><td>Pairs mapped to different chromosomes</td><td>'+str(res.paired_diff_chrom)+'</td></tr>\n' + + tohtml += '<tr><td>rRNA Reads</td><td>'+str(res.rRNA_read)+'</td></tr></tbody></table></div>\n' + + + + tohtml += '<div class="module"><h2 id="M'+str(i)+'1">Read Distribution</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/'+os.path.basename(res.read_dist_plot_file1)+'" alt="Read Distribution"><img class="indented" src="./figs/'+os.path.basename(res.read_dist_plot_file2)+'" alt="Read Distribution"></p></div>\n' + + if res.no_clipping : + + tohtml += '<div class="module"><h2 id="M'+str(i)+'2">Mappability Profile</h2>\n' + + tohtml += '<p>There is no soft clipping. <img class="indented" src="./figs/'+os.path.basename(res.mapq_plot_file)+'" alt="MapQ Profile"> </p></div>\n' + + else : + + tohtml += '<div class="module"><h2 id="M'+str(i)+'2">Mappability</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/'+os.path.basename(res.clipping_plot_file)+'" alt="Mappablity Profile"> <img class="indented" src="./figs/'+os.path.basename(res.mapq_plot_file)+'" alt="MapQ Profile"></p></div>\n' + + + + tohtml += '<div class="module"><h2 id="M'+str(i)+'3">Coverage</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/'+os.path.basename(res.read_cov_plot_file)+'" alt="Read Coverage"> <img class="indented" src="./figs/'+os.path.basename(res.trans_cov_plot_file)+'" alt="Read Coverage"></p></div>\n' + + + + if res.is_pairEnd : + + tohtml += '<div class="module"><h2 id="M'+str(i)+'4">Read Length and Insertion Size</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/'+os.path.basename(res.readLen_plot_file)+'" alt="Read Length"> <img class="indented" src="./figs/'+os.path.basename(res.insert_plot_file)+'" alt="Insertion Size"></p></div>\n' + + else : + + tohtml += '<div class="module"><h2 id="M'+str(i)+'4">Read Length</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/'+os.path.basename(res.readLen_plot_file)+'" alt="Read Length"></p></div>\n' + + + + if len(res_list) >1 : + + tohtml += '<div class="Smp_corr"><h2 id="M'+str(smp_corr_pos)+'">Sample Correlation and Quality</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/smp_corr.png" alt="Sample Correlation"><img class="indented" src="./figs/smp_qual.png" alt="Sample Correlation"></p>\n' + + + + if res.is_pairEnd : + + tohtml += '<h2 id="M'+str(smp_corr_pos)+'">Sample Coverage and Insert size</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/smp_cov.png" alt="Sample Coverage"><img class="indented" src="./figs/smp_inner.png" alt="Sample insert size"></p></div>\n' + + else : + + tohtml += '<h2 id="M'+str(smp_corr_pos)+'">Sample Coverage</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/smp_cov.png" alt="Sample Coverage"></p></div>\n' + + tohtml += '<h2 id="M'+str(smp_corr_pos)+'">Sample Variation</h2>\n' + + tohtml += '<p><img class="indented" src="./figs/smp_reproducibility.png" alt="Sample Variation"><img class="indented" src="./figs/smp_var.png" alt="Sample Variation"></p></div>\n' + + + + tohtml += '</div>\n' + + + + tohtml += '<div id="footer"><p>Produced by Bioinformatics Shared Resource at CSHL </p></div></div></div></body></html>\n' + + + + try : + + f = open(html_file,'w') + + + + f.write(tohtml+"\n") + + f.close() + + except : + + sys.stderr.write("Cannot generate the final report. \n") + + sys.exit(1) + + + + + + + +def prepare_parser (): + + """ inputs(parameters) required/allowed in this pipeline """ + + desc = "Quality control of mapped NGS data (BAM/SAM files) ." + + + + + + exmp = "Example: ezBAMQC -r mm9_refGene.gtf -i treat1.bam treat2.bam treat3.bam -q 30 --rRNA mm9_rRNA.bed -o bamqc_out" + + parser = argparse.ArgumentParser(description = desc,epilog = exmp) + + parser.add_argument('-i', '--inputFile', metavar = 'alignment_files', dest = 'ifiles', nargs = '+', required = True, + + help = 'Alignment files. Could be multiple SAM/BAM files separated by space. Required.') + + parser.add_argument('-r', '--refgene', metavar = 'refgene', dest='ref_gene_model', nargs = '?', type=str, required = True,help = 'refGene GTF file. Required') + + + + parser.add_argument('-f', metavar='attrID', dest='attrID', nargs='?', type=str, default="gene_id", + + help='The read summation at which feature level in the GTF file. DEFAULT: gene_id.') + + + + parser.add_argument('--rRNA', metavar = 'rRNA', dest='rRNA_model', nargs = '?', type=str, default="", + + help = 'rRNA BED file.') + + parser.add_argument('-o', '--outputDir', metavar = 'dir', dest='dir', nargs = '?', type=str, required = True, + + help = 'output directory. Required.') + +# parser.add_argument('-i', '--index', metavar = 'transript_Index', dest='trIdx', nargs = '?', + +# help = 'Transcriptome index file.') + + parser.add_argument('--stranded', metavar='stranded', dest='stranded', nargs='?', type=str, default="yes", choices=['yes','no','reverse'], + + help='Is this a stranded library? (yes, no, or reverse). DEFAULT: yes.') + + + + parser.add_argument('-q', '--mapq', metavar = 'mapq', dest='mapq', nargs = '?', default=30, type=int, + + help = 'Minimum mapping quality (phred scaled) for an alignment to be called uniquely mapped. DEFAULT:30') + + #parser.add_argument('-l', '--lowBound', metavar = 'lb', dest='lb', nargs = '?', default=-250, type=int, + + # help = 'Lower bound for plotting insert size distribution. DEFAULT:-250') + + #parser.add_argument('-u', '--upperBound', metavar = 'ub', dest='ub', nargs = '?', default=250, type=int, + + # help = 'Upper bound for plotting insert size distribution. DEFAULT:250') + + #parser.add_argument('-s', '--stepSize', metavar = 'stepsize', dest='step_size', nargs = '?', default=5, type=int, + + # help = 'Step size for plotting insert size distribution. DEFAULT:5') + + parser.add_argument('-l','--label',metavar = 'labels', dest = 'labels', nargs = '+', + + help = 'Labels of input files. DEFAULT:smp1 smp2 ...') + + #parser.add_argument('-p', '--processes', dest='numProc', default=1, type=int,help='Number of processes to use .DEFAULT:1') + + parser.add_argument('-t', '--threads', dest='numThreads', default=1, type=int,help='Number of threads to use .DEFAULT:1') + + + + return parser + + + + + + + +def read_opts(parser): + + ''' object parser contains parsed options ''' + + + + args = parser.parse_args() + + args.numProc = 1 + + # logging object + + logging.basicConfig(level=20, + + format='%(levelname)-5s @ %(asctime)s: %(message)s ', + + datefmt='%a, %d %b %Y %H:%M:%S', + + stream=sys.stderr, + + filemode="w" + + ) + + + + #treatment files + + if args.labels is not None : + + if len(args.labels) >0 and len(args.ifiles) != len(args.labels) : + + logging.error("Number of labels does not match with the number of samples.\n") + + sys.exit(1) + + + + + + if args.labels is None : + + args.labels = [] + + + + for i in range(len(args.ifiles)) : + + if not os.path.isfile(args.ifiles[i]) : + + logging.error("No such file: %s !\n" % (args.ifiles[i])) + + sys.exit(1) + + if len(args.labels) < len(args.ifiles) : + + args.labels.append("smp"+str(i)) + + + + + +# if args.trIdx is None : + +# logging.warning("Trancsriptome index file is not available.\n") + +# + +# else : + +# if not os.path.isfile(args.trIdx) : + +# logging.error("No such file : %s !\n" %(args.trIdx)) + +# sys.exit(1) + + + + if args.stranded not in ['yes', 'no', 'reverse'] : + + logging.error("Does not support such stranded value: %s !\n" % (args.stranded)) + + sys.exit(1) + + + + if args.mapq is None : + + args.mapq = 30 + + + + if args.rRNA_model is not None and args.rRNA_model != "": + + if not os.path.isfile(args.rRNA_model) : + + logging.error("No such file : %s \n" %(args.rRNA_model)) + + sys.exit(1) + + + + if args.rRNA_model is None : + + args.rRNA_model = "" + + + + if args.attrID is None or args.attrID == "": + + logging.error("please specify the read summation at which feature level in the GTF file\n") + + sys.exit(1) + + + + if args.ref_gene_model is None : + + logging.error("reference gene model is required.\n") + + sys.exit(1) + + else : + + if not os.path.isfile(args.ref_gene_model) : + + logging.error("No such file : %s !\n" %(args.ref_gene_model)) + + sys.exit(1) + + + + # logging alias + + args.critical = logging.critical + + args.error = logging.error + + args.warn = logging.warning + + args.debug = logging.debug + + args.info = logging.info + + + + return args + + + + + +if __name__ == '__main__': + + try: + + start_time = time.time() + + main() + + end_time = time.time() + + sys.stderr.write("Elapsed time was " + str(round((end_time - start_time) / 60, 2)) + " minutes.\n") + + except KeyboardInterrupt: + + sys.stderr.write("User interrupt !\n") + + sys.exit(0) +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/setup.py Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,226 @@ +#!/usr/bin/env python2.7 +# Setup for ezBAMQC, utilities for the Sequence Alignment/Map format. +# +# Copyright (C) 2015 Bioinformatics Shared Resource, CSHL. +# Portions copyright (C) 2015 Cold Spring Harbor Laboratory. +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +import argparse +import sys, os, glob, fnmatch + +## Added 10 Jan 2008 +from distutils.core import setup, Extension +import distutils.command.install_data + +## Code borrowed from wxPython's setup and config files +## Thanks to Robin Dunn for the suggestion. +## I am not 100% sure what's going on, but it works! +def opj(*args): + path = os.path.join(*args) + return os.path.normpath(path) + +## Added 10 Jan 2008 +# Specializations of some distutils command classes +class wx_smart_install_data(distutils.command.install_data.install_data): + """need to change self.install_dir to the actual library dir""" + def run(self): + install_cmd = self.get_finalized_command('install') + self.install_dir = getattr(install_cmd, 'install_lib') + return distutils.command.install_data.install_data.run(self) + +def find_data_files(srcdir, *wildcards, **kw): + # get a list of all files under the srcdir matching wildcards, + # returned in a format to be used for install_data + def walk_helper(arg, dirname, files): + if '.svn' in dirname: + return + names = [] + lst, wildcards = arg + for wc in wildcards: + wc_name = opj(dirname, wc) + for f in files: + filename = opj(dirname, f) + + if fnmatch.fnmatch(filename, wc_name) and not os.path.isdir(filename): + names.append(filename) + if names: + lst.append( (dirname, names ) ) + + file_list = [] + recursive = kw.get('recursive', True) + if recursive: + os.path.walk(srcdir, walk_helper, (file_list, wildcards)) + else: + walk_helper((file_list, wildcards), + srcdir, + [os.path.basename(f) for f in glob.glob(opj(srcdir, '*'))]) + return file_list + +## This is a list of files to install, and where: +## Make sure the MANIFEST.in file points to all the right +## directories too. +files = find_data_files('ezBAMQC/', '*.*') + +from distutils.core import setup + +def readme(): + with open('README.rst') as f: + return f.read() + +if sys.version_info[0] != 2 or sys.version_info[1] < 7: + print >> sys.stderr, "ERROR: ezBAMQC requires Python 2.7" + sys.exit() + +BAMQC_HEADER = [ + 'src/bamqc/Constants.h', + 'src/bamqc/Coverage_prof.h', + 'src/bamqc/GeneFeatures.h', + 'src/bamqc/InnerDist_prof.h', + 'src/bamqc/IntervalTree.h', + 'src/bamqc/Mappability.h', + 'src/bamqc/parseBAM.h', + 'src/bamqc/ReadDup_prof.h', + 'src/bamqc/Results.h', + 'src/bamqc/rRNA.h' +] + +BAMQC_SOURCE = [ + 'src/bamqc/Coverage_prof.cpp', + 'src/bamqc/GeneFeatures.cpp', + 'src/bamqc/InnerDist_prof.cpp', + 'src/bamqc/IntervalTree.cpp', + 'src/bamqc/Mappability.cpp', + 'src/bamqc/parseBAM.cpp', + 'src/bamqc/ReadDup_prof.cpp', + 'src/bamqc/Results.cpp', + 'src/bamqc/rRNA.cpp' +] + +###TODO HAVE TO SPLIT INTO TWO AND MAKE THE A FILE +HTSLIB_PUBLIC_HEADERS = [ + 'src/htslib/bgzf.h', + 'src/htslib/faidx.h', + 'src/htslib/hfile.h', + 'src/htslib/hts.h', + 'src/htslib/hts_defs.h', + 'src/htslib/khash.h', + 'src/htslib/klist.h', + 'src/htslib/knetfile.h', + 'src/htslib/kseq.h', + 'src/htslib/ksort.h', + 'src/htslib/kstring.h', + 'src/htslib/regidx.h', + 'src/htslib/sam.h', + 'src/htslib/synced_bcf_reader.h', + 'src/htslib/tbx.h', + 'src/htslib/vcf.h', + 'src/htslib/vcf_sweep.h', + 'src/htslib/vcfutils.h' +] + + +HTSLIB = [ + 'src/htslib/bgzf.c', + 'src/htslib/faidx.c', + 'src/htslib/hfile.c', + 'src/htslib/hfile_net.c', + 'src/htslib/hts.c', + 'src/htslib/kfunc.c', + 'src/htslib/knetfile.c', + 'src/htslib/kstring.c', + 'src/htslib/regidx.c', + 'src/htslib/sam.c', + 'src/htslib/synced_bcf_reader.c', + 'src/htslib/tbx.c', + 'src/htslib/vcf.c', + 'src/htslib/vcfutils.c', + 'src/htslib/cram/cram_codecs.c', + 'src/htslib/cram/cram_decode.c', + 'src/htslib/cram/cram_encode.c', + 'src/htslib/cram/cram_index.c', + 'src/htslib/cram/cram_io.c', + 'src/htslib/cram/cram_samtools.c', + 'src/htslib/cram/cram_stats.c', + 'src/htslib/cram/files.c', + 'src/htslib/cram/mFILE.c', + 'src/htslib/cram/md5.c', + 'src/htslib/cram/open_trace_file.c', + 'src/htslib/cram/pooled_alloc.c', + 'src/htslib/cram/rANS_static.c', + 'src/htslib/cram/sam_header.c', + 'src/htslib/cram/string_alloc.c', + 'src/htslib/cram/thread_pool.c', + 'src/htslib/cram/vlen.c', + 'src/htslib/cram/zfio.c' +] + +BAMqc_CFLAGS = ['-fpermissive','-O3','-std=c++11','-Wno-error=declaration-after-statement'] +BAMqc_DFLAGS = [('_FILE_OFFSET_BITS','64'),('_LARGEFILE64_SOURCE',''),('_CURSES_LIB','1')] +BAMqc_INCLUDES = ['./src/htslib'] +BAMqc_HEADERS = ['./src/bamqc'] +BAMqc_EXTRA = ['build/lib.linux-x86_64-2.7/htslib.so'] + +htslib_CFLAGS = ['-Wno-error=declaration-after-statement'] +htslib_HEADERS = ['./src/htslib','./src/htslib/htslib','./src/htslib/cram'] +htslib_DFLAGS = [('_FILE_OFFSET_BITS','64'),('_USE_KNETFILE','')] + +setup(name = "ezBAMQC", + version = "0.6.5", + description = 'Quality control tools for NGS alignment file', + keywords = 'Quality control BAM file', + # make sure to add all the nessacary requires + dependency_links=['https://gcc.gnu.org/gcc-4.8/','https://www.r-project.org/','https://cran.r-project.org/web/packages/corrplot/'], + cmdclass = { 'install_data': wx_smart_install_data }, + scripts = ["ezBAMQC"], + author = "Ying Jin", + author_email ="yjin@cshl.edu", + license='GPLv3', + platforms = ['Linux'], + url='http://hammelllab.labsites.cshl.edu/software#BAMqc', + long_description=readme(), + classifiers=[ + 'Development Status :: 4 - Beta', + 'Natural Language :: English', + 'License :: OSI Approved :: GNU General Public License v3 (GPLv3)', + 'Topic :: Scientific/Engineering :: Bio-Informatics', + 'Intended Audience :: Science/Research', + 'Programming Language :: Python :: 2.7', + 'Programming Language :: C++', + 'Operating System :: Unix', + ], + zip_safe = False, + include_package_data=True, + ext_modules = [ + Extension('htslib', + sources = HTSLIB, + include_dirs = htslib_HEADERS, + extra_compile_args = htslib_CFLAGS, + define_macros = htslib_DFLAGS, + libraries=['z'] + ), + Extension('libBAMqc', + sources = BAMQC_SOURCE, + extra_compile_args = BAMqc_CFLAGS, + include_dirs = BAMqc_HEADERS + htslib_HEADERS, + extra_objects = BAMqc_EXTRA, + define_macros = BAMqc_DFLAGS + ) + ] + )
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/Constants.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,37 @@ +// +// Constants.h +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef BAMQC_c___Constants_h +#define BAMQC_c___Constants_h + +#include <limits> + +#define BIN_SIZE 100000 + +#define MAX_BUCKET 128 +#define MIN_BUCKET 16 +#define DEPTH 16 + +//#define SAMPLESIZE 500000 +#define SAMPLESIZE std::numeric_limits<int>::max() +#define LOW_BOUND -200 +#define UPPER_BOUND 1000 +#define STEP 10 + +#define CDS 1 +#define UTR5 2 +#define UTR3 3 +#define INTRON 4 +#define ITGUP1K 5 +#define ITGDN1K 6 +#define INTERGENIC 7 +#define RRNA 8 + +#define MAX_READ_LEN 1000 + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/Coverage_prof.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,217 @@ +// +// Coverage_prof.cpp +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "Coverage_prof.h" + +#include <string> +//#include <stdio> +#include <iostream> +#include <fstream> +#include <stdlib.h> + + + +Coverage_prof::Coverage_prof(std::string outfile_data,std::string outfile_fig, GeneFeatures * geneIdx) +{ + frag_num = 0; + cov_script_file = outfile_data + ".geneBodyCoverage_plot.r"; + cov_data_file = outfile_data + ".geneBodyCoverage.txt"; + cov_fig_file = outfile_fig + ".geneBodyCoverage.png"; + + transcov_fig_file = outfile_fig + ".TransCoverage.png"; + transcov_script_file = outfile_data + ".TransCoverage.r"; + transcov_data_file = outfile_data + ".geneAbundance.txt"; + + int num_of_genes = geneIdx->get_numofgenes(); + int num_of_exons = geneIdx->total_exon; + //geneCounts_list[num_of_genes]; + for (int i=0; i< num_of_genes; i++) { + geneCounts_list.push_back(0); + std::vector<int> idx_cnt ; + for(int j=0;j<=100; j++) + { + idx_cnt.push_back(0); + } + gene_percentile_base.push_back(idx_cnt); + } + //std::cout << num_of_genes << std::endl; + for (int i=0; i< num_of_exons; i++) { + mapped_exon.push_back(0); + } + gene_Idx = geneIdx; + total_exons = num_of_exons; +} + +Coverage_prof::Coverage_prof(GeneFeatures * geneIdx){ + gene_Idx = geneIdx; + frag_num = 0; + total_exons = geneIdx->total_exon; + + int num_of_genes = geneIdx->get_numofgenes(); + int num_of_exons = geneIdx->total_exon; + //geneCounts_list[num_of_genes]; + for (int i=0; i< num_of_genes; i++) { + geneCounts_list.push_back(0); + std::vector<int> idx_cnt ; + for(int j=0;j<=100; j++) + { + idx_cnt.push_back(0); + } + gene_percentile_base.push_back(idx_cnt); + } + //std::cout << num_of_genes << std::endl; + for (int i=0; i< num_of_exons; i++) { + mapped_exon.push_back(0); + } + +} + +int Coverage_prof::write(int totalReads){ + int coverage[101] = {0}; + //total_exons = 0; + int zero_exons = 0; + //std::cout << "start to write" << std::endl; + + for(size_t i=0;i< gene_percentile_base.size();i++) + { + std::vector<int> percentile_list = gene_percentile_base[i]; + for(size_t j=0;j< percentile_list.size();j++){ + coverage[j] += percentile_list[j]; + + } + + } + std::string geneCnt_str = ""; + for (size_t i=0;i<geneCounts_list.size(); i++) { + geneCnt_str += ',' + std::to_string(geneCounts_list[i]); + } + std::string x_coord=""; + std::string y_coord=""; + try { + std::ofstream OUT1, OUT2, OUT3, OUT4; + OUT2.open(cov_data_file,std::ofstream::out); + OUT3.open(transcov_data_file,std::ofstream::out); + OUT3 << "gene" << "\t" << "Counts\n"; + if (geneCnt_str !=""){ + OUT4.open(transcov_script_file,std::ofstream::out); + + OUT4 << "png(\'" << transcov_fig_file << "\',width=500,height=500,units='px')\n"; + OUT4 << "a=c("<< geneCnt_str.substr(1) << ")\n"; + OUT4 << "Fn = ecdf(a)\n"; + OUT4 << "max_x = round(log(max(knots(Fn)),2),0)\n"; + OUT4 << "xx = c(0,2^seq(0,max_x,by=2))\n"; + OUT4 << "y=Fn(xx)\n"; + OUT4 << "xlog = log(xx[2:length(xx)],base=2)\n"; + OUT4 << "plot(x=c(-1,xlog),y=y,xaxt = 'n',type=\"b\",col=\"blue\",pch=20,xlab=\"Number of Reads\",ylab=\"Cumulative proportion of Genes\")\n"; + OUT4 << "axis(1,at = c(-1,seq(0,max_x,by=2)),labels=c(0,2^seq(0,max_x,by=2)))\n"; + OUT4 << "dev.state = dev.off()"; + OUT4.close(); + } + OUT2 << "Total reads: " << std::to_string(totalReads) << "\n"; + OUT2 << "Fragment number: " << frag_num << "\n"; + OUT2 << "percentile\tcount\n"; + + for(int i=0; i< 101;i++){ + x_coord += ',' + std::to_string(i); + y_coord += ',' + std::to_string(coverage[i]); + + OUT2 << std::to_string(i) << '\t' << std::to_string(coverage[i]) << "\n"; + } + if(x_coord != ""){ + OUT1.open(cov_script_file,std::ofstream::out); + OUT1 << "png(\'" << cov_fig_file << "\',width=500,height=500,units='px')\n"; + OUT1 << "x=c(" << x_coord.substr(1) << ")\n"; + OUT1 << "y=c(" << y_coord.substr(1) << ")\n"; + + OUT1 << "smoothsp = smooth.spline(x,y,spar=0.35)\n"; + OUT1 << "plot(smoothsp,type=\"l\",col=\"blue\",xlab=\"Percentile of Gene Body (5\'->3\')\",ylab=\"Number of read\",xlim=c(0,100))\n"; + OUT1 << "dev.state = dev.off()"; + + OUT1.close(); + } + OUT2.close(); + + for(size_t i=0;i<geneCounts_list.size();i++) + { + + OUT3 << gene_Idx->get_name(i) << "\t" << std::to_string(geneCounts_list[i]) << "\n"; + } + OUT3.close(); + + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing clipping profile." << std::endl; + return -1; + } + zero_exons = total_exons; + for (size_t i=0; i< mapped_exon.size(); i++) { + if (mapped_exon[i] > 0) { + zero_exons --; + } + } + return zero_exons; +} + +void Coverage_prof::add(Coverage_prof * cov_prof) +{ + frag_num += cov_prof->frag_num; + + for(size_t i=0;i< geneCounts_list.size();i++){ + geneCounts_list[i] += cov_prof->geneCounts_list[i]; + } + + for(size_t i=0;i<gene_percentile_base.size();i++){ + std::vector<int> * g0_perc_cnt = &(gene_percentile_base[i]); + std::vector<int> g1_perc_cnt = cov_prof->gene_percentile_base[i]; + for (size_t j=0; j<= 100; j++ ) { + g0_perc_cnt->at(j) = g1_perc_cnt[j] + g0_perc_cnt->at(j); + } + } + for (int i=0; i< total_exons; i++) { + mapped_exon[i] += cov_prof->mapped_exon[i]; + } +} + +void Coverage_prof::count(int gene,std::vector<std::pair<int,int> > exon_blocks1,std::vector<std::pair<int,int> > exon_blocks2,std::vector<int> exons) +{ + for (size_t i=0; i < exons.size(); i++) { + mapped_exon[exons[i]] =1; + } + if (gene != -1){ + frag_num += exon_blocks1.size() + exon_blocks2.size(); + geneCounts_list[gene] += 1; + + //__per_base_count(gene,exon_blocks,exon_blocks2); + int gene_start = gene_Idx->get_start(gene); + int gene_stop = gene_Idx->get_stop(gene); + for (auto& kv : exon_blocks1) { + if (kv.second >= gene_start && kv.first <= gene_stop) + { + for (int j=kv.first; j<=kv.second; j++) { + int idx = gene_Idx->exist_in_percentile_list(gene,j); + if (idx != -1) { + gene_percentile_base[gene][idx] +=1; + } + } + } + } + + for (auto& kv : exon_blocks2) { + if (kv.second >= gene_start && kv.first <= gene_stop) + { + for (int j=kv.first; j<=kv.second; j++) { + int idx = gene_Idx->exist_in_percentile_list(gene,j); + if (idx != -1) { + gene_percentile_base[gene][idx] +=1; + } + } + } + } + + } +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/Coverage_prof.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,43 @@ +// +// Coverage_prof.h +// BAMQC_c++ +// +// Created by Ying Jin on 11/18/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_c____Coverage_prof__ +#define __BAMQC_c____Coverage_prof__ + +#include <stdio.h> +#include <vector> +#include <utility> + +#include "GeneFeatures.h" + +class Coverage_prof{ +public: + int frag_num ; + int total_exons; + GeneFeatures * gene_Idx; + + std::string cov_script_file ; + std::string cov_data_file ; + std::string cov_fig_file ; + + std::vector<int> geneCounts_list; + std::vector<int> mapped_exon; + std::vector<std::vector<int> > gene_percentile_base; + + std::string transcov_fig_file ; + std::string transcov_script_file ; + std::string transcov_data_file ; + + Coverage_prof(GeneFeatures * geneIdx); + Coverage_prof(std::string outfile_data,std::string outfile_fig, GeneFeatures * geneIdx); + int write(int totalReads); + void add(Coverage_prof * cov_prof); + void count(int gene,std::vector<std::pair<int,int> > exon_blocks1,std::vector<std::pair<int,int> > exon_blocks2,std::vector<int> exons); +}; + +#endif /* defined(__BAMQC_c____Coverage_prof__) */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/GeneFeatures.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1065 @@ +// +// GeneFeatures.cpp +// BAMQC-0.5 +// +// Created by Ying Jin on 9/15/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "GeneFeatures.h" + +#include <cmath> +#include <fstream> +#include <sstream> +//#include <regex> +#include "stdlib.h" +#include <algorithm> +#include <iostream> +#include <math.h> +#include <iterator> + + +//#include <boost/tokenizer.hpp> + +//template <class T1, class T2, class Pred = std::less<T2> > +//struct sort_pair_second { +//(const std::pair<T1,T2>&left, const std::pair<T1,T2>&right) { +// Pred p; +// return p(left.second, right.second); +// } +//}; +//bool sort_pair_second(std::pair<int,int> first, std::pair<int,int> second) +//{ +// return first.second > second.second ; +//} + +bool itv_comp(Interval first, Interval second){ + return first.start < second.start ; +} + +int pivot(std::vector<Interval> &intervals, int first, int last) +{ + int p = first; + int pivotElement = intervals[first].start; + + + for(int i = first+1 ; i <= last ; i++) + { + /* If you want to sort the list in the other order, change "<=" to ">" */ + if(intervals[i].start <= pivotElement) + { + std::swap(intervals[i],intervals[p]); + p++; + + } + } + + return p; +} + +void quick_sort(std::vector<Interval> &intervals, int first, int last){ + + int pivotElement; + + if(first < last) + { + pivotElement = pivot(intervals, first, last); + quick_sort(intervals, first, pivotElement-1); + quick_sort(intervals, pivotElement+1, last); + } + +} + + +bool reverse_ord_func (int i,int j) { return (j<i); } + + +Gene::Gene(std::string gid, std::string ss){ + id = gid; + strand = ss ; + min_start = std::numeric_limits<int>::max(); + max_stop = std::numeric_limits<int>::min(); + gene_actual_len = 0; + stop_codon_st = -1; + stop_codon_end = -1; +} + +Gene::~Gene(){} + +void Gene::add_cds(int st, int end){ + std::pair<int,int> cds_interval (st,end); + cds.push_back(cds_interval); +} + +void Gene::add_exons(int st, int end){ + if (this->min_start > st) { + this->min_start = st; + } + if (this->max_stop<end) { + this->max_stop = end; + } + std::pair<int,int> exon_interval (st,end); + gene_actual_len += (end - st+1); + exons.push_back(exon_interval); +} +void Gene::set_stop_codon(int st,int end) +{ + stop_codon_st = st; + stop_codon_end = end; +} + + +void Gene::get_others(){ + std::vector<std::pair<int,int> > left_cds; + std::vector<std::pair<int,int> > left_exons; + //int idx[exons.size()]; + size_t i; //,j; + int itgUp1k_st, itgUp1k_end,itgDn1k_st,itgDn1k_end ; + + sort(exons.begin(),exons.end()); + sort(cds.begin(),cds.end()); + + + for (i = 1; i < exons.size(); i++) { + intron.push_back(std::make_pair(exons[i-1].second +1, exons[i].first -1)); + } + + if(strand == "+") { + itgUp1k_st = std::max(int(0),exons[0].first-1000); + itgUp1k_end = std::max(int(0),exons[0].first-1 ); + itgDn1k_st = exons[exons.size()-1].second + 1; + itgDn1k_end = exons[exons.size()-1].second + 1000 ; + itg1k.push_back(std::make_pair(itgUp1k_st,itgUp1k_end)) ; + itg1k.push_back(std::make_pair(itgDn1k_st,itgDn1k_end)) ; + + if (stop_codon_st == -1) { + utr5 = exons; + } + else { + cds[cds.size()-1].second = stop_codon_end; + for( i=0;i < exons.size(); i++) { + + if (exons[i].second < cds[0].first) { utr5.push_back(exons[i]); } + + if (exons[i].first < cds[0].first && exons[i].second > cds[0].first ) { utr5.push_back(std::make_pair(exons[i].first,cds[0].first - 1)); } + + if (exons[i].first <= stop_codon_st && exons[i].second > stop_codon_end ) + { utr3.push_back(std::make_pair(stop_codon_end + 1,exons[i].second)); } + if (exons[i].first > stop_codon_end ) { utr3.push_back(exons[i]) ; } + + } + } + + } + else { + itgDn1k_st = std::max(int(0),exons[0].first - 1000); + itgDn1k_end = std::max(int(0),exons[0].first -1); + itgUp1k_st = exons[exons.size()-1].second + 1 ; + itgUp1k_end = exons[exons.size()-1].second + 1000 ; + itg1k.push_back(std::make_pair(itgUp1k_st,itgUp1k_end)); + itg1k.push_back(std::make_pair(itgDn1k_st,itgDn1k_end)); + + if (stop_codon_st == -1 ) { utr3 = exons; } + else { + //if (left_cds.size() == 1) { + cds[0].first = stop_codon_st; + for( i=0;i < exons.size(); i++) { + + if (exons[i].second < stop_codon_st) { utr3.push_back(exons[i]); } + + if (exons[i].first < stop_codon_st && exons[i].second >= stop_codon_end ) + { utr3.push_back(std::make_pair(exons[i].first,stop_codon_st - 1)); } + + if (exons[i].first <= cds[cds.size()-1].first && exons[i].second > cds[cds.size()-1].second ) + { utr5.push_back(std::make_pair(cds[cds.size()-1].second + 1,exons[i].second)); } + + if (exons[i].first > cds[cds.size()-1].second ) { utr5.push_back(exons[i]) ; } + } + } + + } + +} + + + +GeneFeatures::GeneFeatures(std::string GTFfilename,std::string id_attribute) +{ + this->total_exon = 0; + read_features(GTFfilename,id_attribute); + +} + +GeneFeatures::~GeneFeatures(){ + chrom_itvTree_Dict_itr it; + + for (it=cds_exon_idx_plus.begin(); it != cds_exon_idx_plus.end(); it++) { + std::map<int,IntervalTree *> tmp = it->second; + std::map<int,IntervalTree *>::iterator tmp_itr ; + //std::cout << tmp.size() << std::endl; + for (tmp_itr = tmp.begin(); tmp_itr != tmp.end(); tmp_itr ++) { + delete tmp_itr->second; + } + + } + for (it=cds_exon_idx_minus.begin(); it != cds_exon_idx_minus.end(); it++) { + std::map<int,IntervalTree *> tmp = it->second; + std::map<int,IntervalTree *>::iterator tmp_itr ; + + for (tmp_itr = tmp.begin(); tmp_itr != tmp.end(); tmp_itr ++) { + delete tmp_itr->second; + } + + } + +} + +void GeneFeatures::build_tree(std::map<std::string, std::map<std::string,Gene> > temp_plus, std::map<std::string, std::map<std::string,Gene> > temp_minus) +{ + std::vector<Interval> itemlist; + std::vector<Interval> sublist; + std::map<std::string, std::map<std::string,Gene> >::iterator it; + std::map<std::string,Gene> tmp; + std::map<std::string,Gene>::iterator tmp_itr; + gene_exon_Dict_It exon_str_itr; + + std::string chr,gid;//,start_ss,end_ss; + + int g_idx =-1; + int e_idx =0; + size_t i ; + int cur_bin_id,start_bin_id, js, je, k;//, buket_size; + + for (it = temp_plus.begin(); it != temp_plus.end(); it++) { + chr = it->first; + tmp = it->second; + itemlist.clear(); + + for (tmp_itr = tmp.begin(); tmp_itr != tmp.end(); tmp_itr++) { + gid = tmp_itr->first; + features.push_back(gid); //save gene name + g_idx +=1; + Gene tmp_gene = tmp_itr->second; + tmp_gene.get_others(); + + //int gene_len = (int) tmp_gene.max_stop - tmp_gene.min_start + 1; + //std::cout << gene_len << std::endl; + + std::vector<int> gene_base_pos ; + + for (i=0; i< tmp_gene.exons.size(); i++) { + int st = (int) tmp_gene.exons[i].first - tmp_gene.min_start; + int end = (int) tmp_gene.exons[i].second - tmp_gene.min_start; + for (int j=st; j<=end; j++) { + gene_base_pos.push_back(j); + } + } + gene_lengths.push_back(tmp_gene.gene_actual_len); + gene_starts.push_back(tmp_gene.min_start); + gene_ends.push_back(tmp_gene.max_stop); + + std::vector<int> percentile_list; + std::sort(gene_base_pos.begin(),gene_base_pos.end()); + + for (int j=0; j<=100;j++) { + float kk = (tmp_gene.gene_actual_len - 1) * j/100.0; + float f = floor(kk); + float c = ceil(kk); + if (f == c){ + percentile_list.push_back( gene_base_pos[kk]); + } + else{ + float d0 = gene_base_pos[int(f)] * (c-kk); + float d1 = gene_base_pos[int(c)] * (kk-f); + percentile_list.push_back(int(round(d0+d1))); + } + } + gene_percentile_list.push_back(percentile_list); + + for (i=0; i < tmp_gene.cds.size(); i++) { + this->total_exon ++ ; + //std::cout<< this->total_exon << std::endl; + itemlist.push_back(Interval(g_idx,e_idx,tmp_gene.cds[i].first,tmp_gene.cds[i].second,CDS)); + e_idx ++; + } + for (i=0; i < tmp_gene.utr5.size(); i++) { + this->total_exon ++ ; + itemlist.push_back(Interval(g_idx,e_idx,tmp_gene.utr5[i].first,tmp_gene.utr5[i].second,UTR5)); + e_idx ++; + } + + for (i=0; i < tmp_gene.utr3.size(); i++) { + this->total_exon ++ ; + //std::cout << chr << "\t" << tmp_gene.utr3[i].first << "\t" << tmp_gene.utr3[i].second << "\t" << gid << std::endl; + itemlist.push_back(Interval(g_idx,e_idx,tmp_gene.utr3[i].first,tmp_gene.utr3[i].second,UTR3)); + e_idx ++; + } + for (i=0; i < tmp_gene.intron.size(); i++) { + itemlist.push_back(Interval(g_idx,-1,tmp_gene.intron[i].first,tmp_gene.intron[i].second,INTRON)); + } + itemlist.push_back(Interval(g_idx,-1,tmp_gene.itg1k[0].first,tmp_gene.itg1k[0].second,ITGUP1K)); + itemlist.push_back(Interval(g_idx,-1,tmp_gene.itg1k[1].first,tmp_gene.itg1k[1].second,ITGDN1K)) ; + + } + + std::sort(itemlist.begin(),itemlist.end(),itv_comp) ; //key=operator.attrgetter('start')); + //quick_sort(itemlist,0,itemlist.size()-1); + start_bin_id = itemlist[0].start/BIN_SIZE; + js = 0 ; + je = 0 ; + k = 0 ; + + + for (i=0; i < itemlist.size(); i++) { + cur_bin_id = itemlist[i].start/BIN_SIZE; + //std::cout << cur_bin_id << std::endl; + + if (cur_bin_id == start_bin_id) { + je += 1; + } + else { + //buket_size = (int)sqrt(je - js) + 1; + //std::cout << buket_size << std::endl; + + sublist = std::vector<Interval>(itemlist.begin()+js,itemlist.begin() + je); + + cds_exon_idx_plus[chr][start_bin_id] = new IntervalTree(sublist); + // std::cout << start_bin_id << " built one tree." << std::endl; + k ++; + start_bin_id = cur_bin_id ; + js = je ; + je ++; + } + } + + + if (js != je) { + //buket_size = (int) sqrt(je - js) + 1; + sublist = std::vector<Interval>(itemlist.begin()+js,itemlist.begin() + je); + cds_exon_idx_plus[chr][start_bin_id] = new IntervalTree(sublist); + //print("tree depth = " + str(cds_exon_idx_plus[chr][start_bin_id].get_depth())+ "\n") + k+=1; + } + + + } + //std::cout << " build minus strand." << std::endl; + for (it = temp_minus.begin(); it != temp_minus.end(); it++) { + //std::cout << "negative strand " << std::endl; + chr = it->first; + tmp = it->second; + itemlist.clear(); + + for (tmp_itr = tmp.begin(); tmp_itr != tmp.end(); tmp_itr++) { + gid = tmp_itr->first; + //std::cout << "GID " << gid << std::endl; + Gene tmp_gene = tmp_itr->second; + tmp_gene.get_others(); + + features.push_back(gid); //save gene name + g_idx +=1; + + //std::string bs_string = ""; + //int gene_len = (int) tmp_gene.max_stop - tmp_gene.min_start + 1; + + //std::vector<std::bitset<100> > bs_list; + std::vector<int> gene_base_pos ; + + /*for (int j=0; j< gene_len; j+=100) { + std::bitset<100> bs; + bs_list.push_back(bs); + }*/ + + for (i=0; i< tmp_gene.exons.size(); i++) { + int st = (int) tmp_gene.exons[i].first - tmp_gene.min_start; + int end = (int) tmp_gene.exons[i].second - tmp_gene.min_start; + //int size = end - st; + + for (int j=st; j<=end; j++) { + gene_base_pos.push_back(j); + } + + } + gene_lengths.push_back(tmp_gene.gene_actual_len); + gene_starts.push_back(tmp_gene.min_start); + gene_ends.push_back(tmp_gene.max_stop); + + std::vector<int> percentile_list; + std::sort(gene_base_pos.begin(),gene_base_pos.end(),reverse_ord_func); + + for (int j=0; j<=100;j++) { + float kk = (tmp_gene.gene_actual_len - 1) * j/100.0; + float f = floor(kk); + float c = ceil(kk); + if (f == c){ + percentile_list.push_back( gene_base_pos[kk]); + } + else{ + float d0 = gene_base_pos[int(f)] * (c-kk); + float d1 = gene_base_pos[int(c)] * (kk-f); + percentile_list.push_back(int(round(d0+d1))); + } + } + gene_percentile_list.push_back(percentile_list); + + + for (i=0; i < tmp_gene.cds.size(); i++) { + total_exon += 1; + itemlist.push_back(Interval(g_idx,e_idx,tmp_gene.cds[i].first,tmp_gene.cds[i].second,CDS)); + e_idx ++; + } + for (i=0; i < tmp_gene.utr5.size(); i++) { + total_exon += 1; + itemlist.push_back(Interval(g_idx,e_idx,tmp_gene.utr5[i].first,tmp_gene.utr5[i].second,UTR5)); + e_idx ++; + } + for (i=0; i < tmp_gene.utr3.size(); i++) { + total_exon += 1; + itemlist.push_back(Interval(g_idx,e_idx,tmp_gene.utr3[i].first,tmp_gene.utr3[i].second,UTR3)); + e_idx ++; + } + for (i=0; i < tmp_gene.intron.size(); i++) { + itemlist.push_back(Interval(g_idx,-1,tmp_gene.intron[i].first,tmp_gene.intron[i].second,INTRON)); + } + itemlist.push_back(Interval(g_idx,-1,tmp_gene.itg1k[0].first,tmp_gene.itg1k[0].second,ITGUP1K)); + itemlist.push_back(Interval(g_idx,-1,tmp_gene.itg1k[1].first,tmp_gene.itg1k[1].second,ITGDN1K)) ; + + } + + //std::sort(key=operator.attrgetter('start')); + //quick_sort(itemlist,0,itemlist.size()-1); + std::sort(itemlist.begin(),itemlist.end(),itv_comp) ; + start_bin_id = itemlist[0].start/BIN_SIZE; + js = 0 ; + je = 0 ; + k = 0 ; + + for (i=0; i < itemlist.size(); i++) { + cur_bin_id = itemlist[i].start/BIN_SIZE; + if (cur_bin_id == start_bin_id) { + je += 1; + } + else { + //buket_size = (int)sqrt(je - js) + 1; + // std::cout << buket_size << std::endl; + + + sublist = std::vector<Interval>(itemlist.begin()+js,itemlist.begin() + je); + //cds_exon_idx_minus[chr][start_bin_id] = new IntervalTree(sublist,16,buket_size,-1,-1,buket_size); + cds_exon_idx_minus[chr][start_bin_id] = new IntervalTree(sublist); + k ++; + start_bin_id = cur_bin_id ; + js = je ; + je ++; + } + } + + + if (js != je) { + //buket_size = (int) sqrt(je - js) + 1; + //std::cout << buket_size << std::endl; + + sublist = std::vector<Interval>(itemlist.begin()+js,itemlist.begin() + je); + //cds_exon_idx_minus[chr][start_bin_id] = new IntervalTree(sublist, 16, buket_size,-1,-1,buket_size ); + cds_exon_idx_minus[chr][start_bin_id] = new IntervalTree(sublist); + //print("tree depth = " + str(cds_exon_idx_plus[chr][start_bin_id].get_depth())+ "\n") + k+=1; + } + + + } + +} +//Reading & processing annotation files +void GeneFeatures::read_features(std::string gff_filename, std::string id_attribute) +{ + + //dict of dicts since the builtin type doesn't support it for some reason + std::map<std::string, std::map<std::string, Gene> > temp_plus ; + std::map<std::string, std::map<std::string, Gene> > temp_minus ; + std::map<std::string, std::map<std::string, Gene> >::iterator tmp_itr; + std::map<std::string, Gene>::iterator id_itr; + + bool matched = false; + //int k = 0; + int i = 0; + int counts = 0 ; + int line_no = 0; + int start = -1; + int end = -1; + std::size_t pos,cur_pos; + //std::string left_str,sub_str; + + std::ifstream input; //(gff_filename); + + try{ + input.open (gff_filename, std::ifstream::in); + + while(! input.eof()){ + + std::string line,chrom,source,feature,start_ss,end_ss,score,strand,frame,attributeStr; + std::stringstream ss; + std::string id = ""; + + if (! std::getline(input,line)){ + break; + } + + line_no ++; + + if (line == "\n" || !line.compare(0,1,"#")) { + continue; + } + + ss << line; + std::getline(ss,chrom,'\t'); + + std::getline(ss,source,'\t'); + std::getline(ss,feature,'\t'); + std::getline(ss,start_ss,'\t'); + std::getline(ss,end_ss,'\t'); + std::getline(ss,score,'\t'); + std::getline(ss,strand,'\t'); + std::getline(ss,frame,'\t'); + std::getline(ss,attributeStr,'\t'); + + //std::cout << strand << std::endl; + try{ + start = std::stol(start_ss); + end = std::stol(end_ss); + } + catch (const std::invalid_argument& ia) { + std::cerr << "Invalid argument: " << ia.what() << '\n'; + std::exit(1); + + } + + cur_pos = 0; + //std::cout <<attributeStr << std::endl; + while (cur_pos < attributeStr.length()) { + std::size_t next_pos = attributeStr.find(";",cur_pos); + if (next_pos !=std::string::npos) { + + std::string tok = attributeStr.substr(cur_pos,(next_pos - cur_pos)); + //std::cout << tok << std::endl; + tok = tok.substr(tok.find_first_not_of(' ')); + pos = tok.find('='); + if (pos == std::string::npos) { + pos = tok.find(' '); + } + std::string key = tok.substr(0,pos); + key = key.substr(0,key.find(' ')); + + std::size_t pos_stop = 1 + pos + tok.substr(pos+1).find_first_not_of(' '); + std::string val = (tok[pos_stop] == '"') ? tok.substr(pos_stop+1, (tok.length() - (pos_stop+2))) : tok.substr(pos_stop, (tok.length() - (pos_stop+1))); + + if (key == id_attribute) { + id = val; + matched = true; + break; + } + cur_pos = next_pos + 1; + } + else { + break; + } + + } + + if (!matched) { + + std::cout << "Failure parsing GFF attribute line." << std::endl; + exit (EXIT_FAILURE); + } + + if (id == "") { + continue; + } + if (feature == "stop_codon") { + if (strand == "+" ){ + tmp_itr = temp_plus.find(chrom); + if (tmp_itr != temp_plus.end()) { + id_itr = temp_plus[chrom].find(id); + if (id_itr != temp_plus[chrom].end()) { + Gene *g = &(id_itr->second); + + (*g).set_stop_codon(start,end); + } + else{ + Gene g (id,strand); + g.set_stop_codon(start,end); + temp_plus[chrom].insert(std::pair<std::string,Gene>(id,g)); + } + } + else{ + Gene g(id,strand); + g.set_stop_codon(start,end); + std::map<std::string, Gene> gene_id_map ; + gene_id_map.insert(std::pair<std::string,Gene> (id,g)); + temp_plus.insert(std::pair<std::string,std::map<std::string, Gene> > (chrom,gene_id_map)); + + } + + } + + if (strand == "-" ) { + tmp_itr = temp_minus.find(chrom); + if (tmp_itr != temp_minus.end()) { + id_itr = temp_minus[chrom].find(id); + if (id_itr != temp_minus[chrom].end()) { + Gene *g = &(id_itr->second); + (*g).set_stop_codon(start,end); + } + else{ + Gene g(id,strand); + g.set_stop_codon(start,end); + std::map<std::string, Gene> gene_id_map ; + temp_minus[chrom].insert(std::pair<std::string,Gene>(id,g)); + + } + } + else{ + Gene g(id,strand); + g.set_stop_codon(start,end); + std::map<std::string, Gene> gene_id_map ; + gene_id_map.insert(std::pair<std::string,Gene> (id,g)); + + temp_minus.insert(std::pair<std::string,std::map<std::string, Gene> > (chrom,gene_id_map)); + + + } + + } + + } + if (feature == "CDS" ){ + if (strand == "+" ){ + tmp_itr = temp_plus.find(chrom); + if (tmp_itr != temp_plus.end()) { + id_itr = temp_plus[chrom].find(id); + if (id_itr != temp_plus[chrom].end()) { + Gene *g = &(id_itr->second); + //(id_itr->second).add_cds(start,end); + (*g).add_cds(start,end); + } + else{ + Gene g (id,strand); + g.add_cds(start,end); + temp_plus[chrom].insert(std::pair<std::string,Gene>(id,g)); + } + } + else{ + Gene g(id,strand); + g.add_cds(start,end); + std::map<std::string, Gene> gene_id_map ; + gene_id_map.insert(std::pair<std::string,Gene> (id,g)); + temp_plus.insert(std::pair<std::string,std::map<std::string, Gene> > (chrom,gene_id_map)); + + } + + } + + if (strand == "-" ) { + + tmp_itr = temp_minus.find(chrom); + if (tmp_itr != temp_minus.end()) { + id_itr = temp_minus[chrom].find(id); + if (id_itr != temp_minus[chrom].end()) { + Gene *g = &(id_itr->second); + (*g).add_cds(start,end); + } + else{ + Gene g(id,strand); + g.add_cds(start,end); + std::map<std::string, Gene> gene_id_map ; + temp_minus[chrom].insert(std::pair<std::string,Gene>(id,g)); + + } + } + else{ + Gene g(id,strand); + g.add_cds(start,end); + std::map<std::string, Gene> gene_id_map ; + gene_id_map.insert(std::pair<std::string,Gene> (id,g)); + + temp_minus.insert(std::pair<std::string,std::map<std::string, Gene> > (chrom,gene_id_map)); + + + } + + } + } + + if (feature == "exon" ){ + counts += 1 ; + if (strand == "+" ){ + tmp_itr = temp_plus.find(chrom); + if (tmp_itr != temp_plus.end()) { + id_itr = temp_plus[chrom].find(id); + if (id_itr != temp_plus[chrom].end()) { + Gene *g = &(id_itr->second); + (*g).add_exons(start,end); + } + else{ + Gene g (id,strand); + g.add_exons(start,end); + + temp_plus[chrom].insert(std::pair<std::string,Gene>(id,g)); + } + } + else{ + Gene g (id,strand); + g.add_exons(start,end); + std::map<std::string, Gene> gene_id_map ; + + gene_id_map.insert(std::pair<std::string,Gene> (id,g)); + temp_plus.insert(std::pair<std::string,std::map<std::string, Gene> > (chrom,gene_id_map)); + + } + + } + + if (strand == "-" ) { + + tmp_itr = temp_minus.find(chrom); + if (tmp_itr != temp_minus.end()) { + + id_itr = temp_minus[chrom].find(id); + if (id_itr != temp_minus[chrom].end()) { + Gene *g = &(id_itr->second); + (*g).add_exons(start,end); + } + else{ + Gene g(id,strand); + g.add_exons(start,end); + + temp_minus[chrom].insert(std::pair<std::string,Gene>(id,g)); + + } + } + else{ + Gene g (id,strand); + g.add_exons(start,end); + std::map<std::string, Gene> gene_id_map ; + gene_id_map.insert(std::pair<std::string,Gene> (id,g)); + + temp_minus.insert(std::pair<std::string,std::map<std::string, Gene> > (chrom,gene_id_map)); + + } + } + + } + + i += 1 ; + //if (i % 100000 == 0 ) + //{ + //sys.stderr.write("%d GTF lines processed.\n" % i); + //std::cout << i << " GTF lines processed." << std::endl; + //} + + } + + + input.close(); + + } + catch(std::ifstream::failure e){ + std::cout << "error in read file " << gff_filename << std::endl; + } + + if (counts == 0 ){ + std::cout << "Warning: No features of type 'exon' or 'CDS' found in gene GTF file." << std::endl; + } + + + build_tree(temp_plus,temp_minus); + + +} + +//find exons of given gene that overlap with the given intervals +//return list of tuples +std::vector<std::pair<int,int> > GeneFeatures::get_exons(std::string chrom,int st,int end,std::string strand) +{ + std::vector<std::pair<int,int> > exons; + chrom_itvTree_Dict::iterator chrom_it; + std::map<int,IntervalTree *>::iterator bin_iter; + std::vector<Interval> fs ; + std::vector<Interval> temp ; + size_t i; + int bin_id ; + + //try: + bin_id = st/BIN_SIZE ; + + if (strand == "+" || strand == "."){ + chrom_it = cds_exon_idx_plus.find(chrom); + if (chrom_it != cds_exon_idx_plus.end()) { + bin_iter = cds_exon_idx_plus[chrom].find(bin_id); + if (bin_iter != cds_exon_idx_plus[chrom].end()) { + fs = (*cds_exon_idx_plus[chrom][bin_id]).find(st,end); + } + } + } + + if (strand == "-" || strand == "."){ + chrom_it = cds_exon_idx_minus.find(chrom); + if (chrom_it != cds_exon_idx_minus.end()) { + bin_iter = cds_exon_idx_minus[chrom].find(bin_id); + if (bin_iter != cds_exon_idx_minus[chrom].end()) { + temp = (*cds_exon_idx_minus[chrom][bin_id]).find(st,end); + fs.insert(fs.end(),temp.begin(),temp.end()); + } + } + } + + for(i =0 ; i < fs.size(); i++){ + if (fs[i].type != INTRON && fs[i].type != ITGUP1K && fs[i].type != ITGDN1K){ + int s = fs[i].start; + int e = fs[i].stop; + + if (s < st) { + s = st; + } + if (e > end) { + e = end; + } + exons.push_back(std::make_pair(s,e)); + } + } + + //std::sort(exons.begin(),exons.end()); + return exons; +} + +std::vector<std::string> GeneFeatures::getFeatures() { + return features ; +} + +int GeneFeatures::get_start(int g) +{ + if ((size_t) g < gene_starts.size() && g >=0) { + return gene_starts[g]; + } + else{ + return -1; + } +} + +int GeneFeatures::get_stop(int g) +{ + if ((size_t)g < gene_ends.size() && g >=0) { + return gene_ends[g]; + } + else{ + return -1; + } +} + +std::string GeneFeatures::get_name(int g) +{ + if ((size_t)g < features.size() && g >=0) { + return features[g]; + } + else{ + return ""; + } + +} +int GeneFeatures::get_numofgenes(){ + return features.size(); +} + +int GeneFeatures::exist_in_percentile_list(int gene,int pos){ + int idx = (int)pos - gene_starts[gene]; + for (int i=0; i<=100; i++) { + + if (idx == gene_percentile_list[gene][i]) { + return i; + } + + } + return -1; +} + + + +std::map<int,int> GeneFeatures::Gene_annotation(std::string chrom, std::vector<std::pair<int,int> > itv_list,std::string strand,std::vector<int> * mapped_exons ) +{ + std::vector<Interval> fs ; + chrom_itvTree_Dict::iterator chrom_it; + std::map<int,IntervalTree *>::iterator bin_iter; + + size_t i,j; + int bin_id_s, bin_id_e; + + for (i=0; i < itv_list.size(); i ++) { + bin_id_s = itv_list[i].first/BIN_SIZE; + bin_id_e = itv_list[i].second/BIN_SIZE; + + if (strand == "+" || strand == ".") { + chrom_it = cds_exon_idx_plus.find(chrom); + if (chrom_it != cds_exon_idx_plus.end()) { + + bin_iter = cds_exon_idx_plus[chrom].find(bin_id_s); + if (bin_iter != cds_exon_idx_plus[chrom].end() ) + { + fs = (*cds_exon_idx_plus[chrom][bin_id_s]).find(itv_list[i].first,itv_list[i].second); + if (bin_id_s != bin_id_e) { + bin_iter = cds_exon_idx_plus[chrom].find(bin_id_e); + if (bin_iter != cds_exon_idx_plus[chrom].end() ){ + std::vector<Interval> tmp = (*cds_exon_idx_plus[chrom][bin_id_e]).find(itv_list[i].first,itv_list[i].second); + fs.insert(fs.end(),tmp.begin(),tmp.end()); + } + } + } + } + } + + if (strand == "-" or strand == ".") { + chrom_it = cds_exon_idx_minus.find(chrom); + if (chrom_it != cds_exon_idx_minus.end()) { + bin_iter = cds_exon_idx_minus[chrom].find(bin_id_s); + if (bin_iter != cds_exon_idx_minus[chrom].end() ) + { + std::vector<Interval> tmp = (*cds_exon_idx_minus[chrom][bin_id_s]).find(itv_list[i].first,itv_list[i].second); + fs.insert(fs.end(),tmp.begin(),tmp.end()); + + if (bin_id_s != bin_id_e) { + bin_iter = cds_exon_idx_minus[chrom].find(bin_id_e); + if (bin_iter != cds_exon_idx_minus[chrom].end() ){ + std::vector<Interval> tmp = (*cds_exon_idx_minus[chrom][bin_id_e]).find(itv_list[i].first,itv_list[i].second); + fs.insert(fs.end(),tmp.begin(),tmp.end()); + } + } + } + } + } + } + + + std::map<int,int> gene_type_map; + std::map<int,int> gene_ovp_len_map; + + std::map<int,int> None_gene_type_map; + std::map<int,int>::iterator gene_type_map_itr; + int min_type = 6; + for (i=0; i < fs.size(); i++) { + if (fs[i].type <= UTR3) { + + int ovp_len = 0; + for(j=0; j < itv_list.size(); j ++) { + if (itv_list[j].first < fs[i].stop && itv_list[j].second > fs[i].start) { + int ovp_st = itv_list[j].first > fs[i].start ? itv_list[j].first : fs[i].start; + int ovp_end = itv_list[j].second > fs[i].stop ? fs[i].stop : itv_list[j].second; + ovp_len += ovp_end - ovp_st+1; + } + } + if (gene_ovp_len_map.find(fs[i].gene) != gene_ovp_len_map.end()) { + gene_ovp_len_map[fs[i].gene] += ovp_len; + if (fs[i].type <= min_type) { + gene_type_map[fs[i].gene] = fs[i].type; + min_type = fs[i].type; + } + + } else { + gene_ovp_len_map.insert(std::pair<int,int> (fs[i].gene,ovp_len)); + gene_type_map.insert(std::pair<int,int>(fs[i].gene,fs[i].type)); + min_type = fs[i].type; + } + } + else { //not CDS or UTR + if (None_gene_type_map.find(fs[i].gene) != None_gene_type_map.end()) + { + if(fs[i].type < None_gene_type_map[fs[i].gene]) + { + None_gene_type_map[fs[i].gene] = fs[i].type; + } + } + else { + None_gene_type_map.insert(std::pair<int, int> (fs[i].gene,fs[i].type)); + } + } + + //genes.push_back(std::pair<int,int>(fs[i].type,fs[i].gene)); + if (fs[i].exon != -1) { + mapped_exons->push_back(fs[i].exon); + } + } + + if (gene_type_map.size() == 0) { + return None_gene_type_map; + } + else { + std::map<int,int> res_gene_type_map; + int max_ovp_len = 0; + for (auto& kv : gene_ovp_len_map) { + if( max_ovp_len < kv.second) { max_ovp_len = kv.second; } + } + for (auto& kv : gene_ovp_len_map) { + if (gene_ovp_len_map[kv.first] == max_ovp_len) { + res_gene_type_map.insert(std::pair<int,int> (kv.first,gene_type_map[kv.first])); + } + } + return res_gene_type_map; + } + + return gene_type_map; + +} +/* + +int main() { + std::string filename = "test.gtf"; + std::string id_attr = "gene_id"; + + std::vector<std::pair<int,int> > itv_list ; + chr_ITV exp ; + exp.chrom = "chr4"; + int start = 1048489; + int end = 1049900; + std::pair<int,int> p (start,end); + + itv_list.push_back(p); + + std::cout << "start to build tree " << std::endl; + GeneFeatures gIdx (filename,id_attr); + std::cout << "after build tree " << std::endl; + + std::cout << "total exon " << gIdx.total_exon << std::endl; + std::cout << "total gene " << gIdx.features.size() << std::endl; + + // for (int i=0; i < itv_list.size(); i++) { + // std::cout << itv_list[i].start << std::endl; + //} + std::vector<int> *exons = new std::vector<int>(); + std::vector<int> res = gIdx.Gene_annotation("chr4",itv_list,".",exons); + std::vector<std::pair<int,int> > exon_list = gIdx.get_exons("chr4",start,end,"."); + for (auto& p : exon_list){ + std::cout << p.first << "\t" << p.second << std::endl; + } + std::vector<std::vector<int> > gene_percentile_list = gIdx.gene_percentile_list; + + for (int i=0; i<gene_percentile_list.size(); i++) { + std::cout << i << std::endl; + std::vector<int> perc_list = gene_percentile_list[i]; + for (int j=0; j<perc_list.size(); j++) { + std::cout << perc_list[j] << "\t"; + } + std::cout << "\n"; + } + + std::cout << exons->size() << std::endl; + + for (int i=0;i<res.size(); i++) { + std::cout << res[i] << std::endl; + //std::cout << exons->operator[](i) << std::endl; + + } + delete exons; + + + bool test_bool = false; + std::cout << test_bool << std::endl; + +}*/
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/GeneFeatures.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,113 @@ +// +// GeneFeatures.h +// BAMQC-0.5 +// +// Created by Ying Jin on 9/15/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_0_5__GeneFeatures__ +#define __BAMQC_0_5__GeneFeatures__ + +#include <stdio.h> +#include <string.h> +#include <vector> +#include <map> +#include <bitset> +#include <utility> + +#include "IntervalTree.h" +#include "Constants.h" +#include <limits> + +typedef struct { + std::string chrom; + int start; + int end; +} chr_ITV; + +extern "C" bool itv_comp(Interval, Interval); + + + +typedef std::map<std::string, std::vector<std::string> > gene_exon_Dict ; +typedef gene_exon_Dict::iterator gene_exon_Dict_It; + +typedef std::map<std::string,std::map<int, IntervalTree *> > chrom_itvTree_Dict ; +typedef chrom_itvTree_Dict::iterator chrom_itvTree_Dict_itr; +//typedef Dict::const_iterator gene_exon_Dict_It; + + +class Gene { +public: + std::vector<std::pair<int,int> > exons; + std::vector<std::pair<int,int> > cds; + std::string id; + std::string strand; + int min_start ; + int max_stop ; + int gene_actual_len; + int stop_codon_st; + int stop_codon_end; + int start_codon_st; + int start_codon_end; + std::vector<std::pair<int,int> > utr5; + std::vector<std::pair<int,int> > utr3 ; + std::vector<std::pair<int,int> > intron ; + std::vector<std::pair<int,int> > itg1k ; + Gene(std::string gid, std::string ss); + //Gene& operator= (const Gene& gg); + //Gene(const std::string gid, const std::string ss); + ~Gene(); + void set_stop_codon(int st, int end); + void add_cds(int st, int end); + void add_exons(int st,int end); + void get_others(); +}; + +class GeneFeatures{ + +public: + std::vector<std::string> features; + std::vector<std::vector<int> > gene_percentile_list; + + std::vector<int> gene_starts; + std::vector<int> gene_ends; + std::vector<int> gene_lengths; + + int total_exon; + + chrom_itvTree_Dict cds_exon_idx_plus ; + chrom_itvTree_Dict cds_exon_idx_minus ; + + GeneFeatures(std::string GTFfilename,std::string id_attribute); + ~GeneFeatures(); + + std::vector<std::string> getFeatures() ; + std::string get_name(int g); + + int get_start(int g); + int get_stop(int g); + int get_numofgenes(); + int exist_in_percentile_list(int gene,int pos); + + std::map<int,int> Gene_annotation(std::string chrom, std::vector<std::pair<int,int> > itv_list, std::string strand,std::vector<int> * mapped_exons); + + std::vector<std::pair<int,int> > get_exons(std::string chrom,int read1_end,int read2_start,std::string strand); + +private: + + void read_features(std::string gff_filename, std::string id_attribute) ; + void build_tree(std::map<std::string, std::map<std::string,Gene> > temp_plus, std::map<std::string, std::map<std::string,Gene> > temp_minus); + +}; + +/*extern "C" { + void quick_sort(std::vector<Interval> &intervals, int first, int last); + int pivot(std::vector<Interval> &intervals, int first, int last); + int get_first(const std::pair<int, int>& p); + + int get_last(const std::pair<int, int>& p); +};*/ + +#endif /* defined(__BAMQC_0_5__GeneFeatures__) */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/InnerDist_prof.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,178 @@ +// +// InnerDist_prof.cpp +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "InnerDist_prof.h" +#include "Mappability.h" +#include <map> +#include <iostream> +#include <fstream> +//#include <stdio> +#include <stdlib.h> +#include <math.h> +#include <htslib/sam.h> + +InnerDist_prof::InnerDist_prof(std::string outfile_data,std::string outfile_fig,int sample_size,int l_bound,int u_bound,int s) +{ + + InnDist_data_file = outfile_data + ".inner_distance_freq.txt"; + InnDist_script_file= outfile_data + ".inner_distance_plot.r"; + InnDist_fig_file = outfile_fig+".inner_distance_plot.png"; + lower_bound = l_bound; + upper_bound = u_bound; + + //samplesize = sample_size; + step = s; + + //window_left_bound = range(lower_bound,up_bound,step); + +} +InnerDist_prof::InnerDist_prof(int sample_size,int l_bound,int u_bound,int s) +{ + lower_bound = l_bound; + upper_bound = u_bound; + + //samplesize = sample_size; + step = s; +} +InnerDist_prof::~InnerDist_prof(){ + +} +void InnerDist_prof::write() +{ + //estimate the inner distance of mRNA pair end fragment. fragment size = insert_size + 2 x read_length''' + if (pair_num == 0){ + return ; + } + try{ + + std::string pos_str = ""; + std::string cnt_str = ""; + int size = ceil((upper_bound-lower_bound)/step)-1; + int to_plot[size]; + + for(int i=0;i<size;i++) + { + to_plot[i] = 0; + } + for (auto& kv: counts){ + if (kv.first >= lower_bound && kv.first <= upper_bound) { + int pos = ceil((kv.first - lower_bound - step/2)/step); + if (pos < 0) { + pos = 0; + } + to_plot[pos] += kv.second; + } + } + std::ofstream FQ ; + FQ.open(InnDist_data_file,std::ofstream::out); + + for(int i=0; i < size; i++) { + int pos = (int)(i*step + lower_bound + step/2); + int pos1 = i*step + lower_bound; + + pos_str +=','+ std::to_string(pos); + cnt_str += ',' + std::to_string(to_plot[i]); + + FQ << pos1 << '\t' << std::to_string(pos1 + step-1) << '\t' << to_plot[i] << '\n' ; + } + FQ.close(); + if(pos_str != ""){ + std::ofstream RS ; + RS.open(InnDist_script_file,std::ofstream::out); + //plot_file = outfile_fig+".inner_distance_plot.png" + RS << "png(\"" << InnDist_fig_file << "\",width=500,height=500,units=\"px\")\n"; + + RS << "fragsize=rep(c(" << pos_str.substr(1) << "),times=c(" << cnt_str.substr(1) << + "))\n"; + RS << "frag_sd = round(sd(fragsize),digits=0)\n"; + RS << "frag_mean = round(mean(fragsize),digits=0)\n"; + RS << "frag_median = round(median(fragsize),digits=0)\n"; + + RS << "hist(fragsize,probability=T,breaks="<< size + 1 <<",xlim=c("<< lower_bound << ',' <<upper_bound << "),xlab=\"Inner distance (bp)\",main=paste(c(\"Median=\",frag_median,\";\",\"Mean=\",frag_mean,\";\",\"SD=\",frag_sd),collapse=\"\"),border=\"blue\")\n"; + + RS << "lines(density(fragsize,bw=" << 2 * step <<"),col='red')\n"; + RS << "abline(v=frag_median,lty=2)\n"; + RS << "dev.state = dev.off()\n"; + + RS.close(); + } + }catch(std::ofstream::failure e){ + std::cout << "Error in writing inner distance profile." << std::endl; + return; + } +} + +void InnerDist_prof::add(InnerDist_prof * inDist) +{ + //samplesize += inDist->samplesize; + pair_num += inDist->pair_num; + + for(auto& kv: inDist->counts) + { + std::map<int, int>::iterator it; + it = counts.find(kv.first); + if (it != counts.end()) { + counts[kv.first] += kv.second; + } + else { + counts[kv.first] = kv.second; + } + } +} + +void InnerDist_prof::count(GeneFeatures * geneIdx,int type,bam1_t * aligned_read,std::string chrom,std::vector<std::pair<int,int> > intron_blocks,std::string strand) +{ + //if (pair_num >= samplesize) + // return ; + int splice_intron_size=0; + //int read1_len = aligned_read->core.l_qseq; //infer_query_length() + uint32_t *cigar = bam_get_cigar(aligned_read); + int read1_len = bam_cigar2mapped_read_len(aligned_read->core.n_cigar,cigar); + + int read1_start = aligned_read->core.pos; + int read2_start = aligned_read->core.mpos; + int read1_end = 0; + + for(auto& intron : intron_blocks){ + splice_intron_size += intron.second - intron.first; + } + + read1_end = read1_start + read1_len + splice_intron_size; + int inner_distance = read2_start - read1_end +1; + // if(inner_distance > -130 && inner_distance < -120) +//{ + // char * name = bam_get_qname(aligned_read); +// printf("read name %s \n", name); + +//} + if (inner_distance >= lower_bound && inner_distance <= upper_bound) + { + pair_num ++; + std::vector<std::pair<int,int> > exons ; + if (type == CDS || type== UTR5 || type== UTR3 ) { + exons = geneIdx->get_exons(chrom,read1_end,read2_start,strand); + } + + if (exons.size() > 0 ) + { + int size = 0; + for (auto& p : exons){ + size += p.second - p.first; + } + if (size <= inner_distance && size > 1){ + counts[size] += 1; + } + else{ + counts[inner_distance] += 1; + } + } + else{ + counts[inner_distance] += 1; + } + } + +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/InnerDist_prof.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,42 @@ +// +// InnerDist_prof.h +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_c____InnerDist_prof__ +#define __BAMQC_c____InnerDist_prof__ + +#include <stdio.h> +#include <vector> +#include <utility> + +#include "GeneFeatures.h" +#include "Constants.h" +#include "htslib/sam.h" + +class InnerDist_prof{ +public: + + std::string InnDist_data_file; + std::string InnDist_fig_file; + std::string InnDist_script_file; + int samplesize = 0; + int step= 0; + int lower_bound = 0; + int upper_bound = 0; + int pair_num = 0; + + std::map<int,int> counts ; + + InnerDist_prof(int sample_size=SAMPLESIZE,int low_bound= LOW_BOUND,int up_bound= UPPER_BOUND,int step= STEP); + InnerDist_prof(std::string data_dir,std::string fig_dir,int sample_size=SAMPLESIZE,int low_bound= LOW_BOUND,int up_bound= UPPER_BOUND,int step= STEP); + ~InnerDist_prof(); + void write(); + void count(GeneFeatures * geneIdx, int type,bam1_t * aligned_read,std::string chrom,std::vector<std::pair<int,int> > intron_blocks,std::string strand); + void add(InnerDist_prof * inDist_prof); +}; + +#endif /* defined(__BAMQC_c____InnerDist_prof__) */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/IntervalTree.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,250 @@ +// +// IntervalTree.cpp +// BAMQC-0.5 +// +// Created by Ying Jin on 9/15/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "IntervalTree.h" +#include <iostream> + +Interval::Interval(int g, int e, int st, int end, int t) { + gene = g; + start = st; + stop = end; + type = t; + exon = e; +} + +Interval::Interval(){} +Interval::~Interval() { } + + + +IntervalTree::IntervalTree(){} + +IntervalTree::IntervalTree(std::vector<Interval> intervals, int depth, int minbucket, int extent_st , int extent_end, int maxbucket){ + + std::vector<Interval> lefts ; + std::vector<Interval> rights ; + int left_ext = 0; + int right_ext = 0; + int max_stop = 0; + float center_pos = 0.0 ; + Interval itv ; + size_t i ; + + left = nullptr; + right = nullptr; + + depth -= 1; + if ((depth == 0 || intervals.size() < (size_t)minbucket) && intervals.size() < (size_t)maxbucket){ + itvlist = intervals; + left = right = nullptr; + center = -1; + return ; + } + + //if (extent_st == -1){ + // sorting the first time through allows it to get + // better performance in searching later. + + // quick_sort(intervals,0,intervals.size()-1); + //} + + for(i=0;i<intervals.size(); i++){ + itv = intervals[i]; + if (itv.stop > max_stop) { max_stop = itv.stop; } + } + + if(extent_st != -1){ + left_ext = extent_st; + right_ext = extent_end; + } + else { + + left_ext = intervals[0].start; + right_ext = max_stop; + } + //left, right = _extent or (intervals[0].start, max_stop) + //center = intervals[len(intervals)/ 2].stop + center_pos = (left_ext + right_ext) / 2.0; + + //std::cout << "left_ext " << left_ext << std::endl; + //std::cout << "right_ext " << right_ext << std::endl; + //std::cout << "center " << center_pos << std::endl; + + for(i=0;i<intervals.size();i++){ + + itv = intervals[i]; + + if (itv.stop < center_pos) { lefts.push_back(itv); } + else { + if (itv.start > center_pos) { rights.push_back(itv);} else { itvlist.push_back(itv) ;} + } + } + if (lefts.empty()) { + left = nullptr; + } + else{ + + left = new IntervalTree(lefts,depth,minbucket,intervals[0].start,center_pos,maxbucket); + } + if (rights.empty()) { + right = nullptr; + } + else { + right = new IntervalTree(rights, depth, minbucket, center_pos,right_ext,maxbucket); + } + + center = center_pos; + +} + +void IntervalTree::clear(IntervalTree * node){ + // std::cout << "clear node" << std::endl; + //if (node != nullptr) { + // std::cout << node->center << std::endl; + //} + if (node != nullptr) { + clear(node->left); + clear(node->right); + // delete node; + } +} + +IntervalTree::~IntervalTree() { + + clear(left); + clear(right); + +/* if (left != nullptr){ + + if( left->left == nullptr && left->right == nullptr) { + delete left; + } + + else { + //if (left->left != nullptr) { + (*left).~IntervalTree(); + // } + //if (left->right != nullptr) { + // (*left->right).~IntervalTree(); + //} + } + } + if (right != nullptr ) { + + if(right->left == nullptr && right->right == nullptr) { + delete right; + } + else{ + // if (right->left != nullptr) { + // (*right->left).~IntervalTree(); + //} + //if (right->right != nullptr) { + // (*right->right).~IntervalTree(); + //} + (*right).~IntervalTree(); + } + } + delete this;*/ +} + + + +std::vector<Interval> IntervalTree::find(int start, int stop){ +//"""find all elements between (or overlapping) start and stop""" + std::vector<Interval> overlapping ; + std::vector<Interval> temp ; + size_t i; + + if (!itvlist.empty() && stop >= itvlist[0].start) { + for (i=0;i< itvlist.size(); i++) { + if (itvlist[i].stop >= start && itvlist[i].start <= stop) { + overlapping.push_back(itvlist[i]); + } + + } + } + + + if( left != nullptr && start <= center) { + temp = (*left).find(start, stop); + overlapping.insert(overlapping.end(), temp.begin(),temp.end()); + } + + if(right != nullptr && stop >= center){ + temp = (*right).find(start, stop); + + overlapping.insert(overlapping.end(),temp.begin(),temp.end()); + } + + return overlapping ; +} + +std::vector<int> IntervalTree::find_gene(int start, int stop){ + + std::vector<int> overlapping ; + std::vector<int> temp ; + size_t i; + + if (!itvlist.empty() && stop >= itvlist[0].start) { + for (i=0;i< itvlist.size(); i++) { + if (itvlist[i].stop >= start && itvlist[i].start <= stop) { + overlapping.push_back(itvlist[i].gene); + } + + } + } + + + if( left != nullptr && start <= center) { + temp = (*left).find_gene(start, stop); + overlapping.insert(overlapping.end(), temp.begin(),temp.end()); + } + + if(right != nullptr && stop >= center){ + temp = (*right).find_gene(start, stop); + + overlapping.insert(overlapping.end(),temp.begin(),temp.end()); + } + + return overlapping ; +} + + +/* +int main(){ + std::vector<Interval> ll; + IntervalTree *Idx; + std::vector<Interval> res; + std::vector<std::string> res_gene; + int i; + + + ll.push_back(Interval("gid1",100,300,"cds")); + ll.push_back(Interval("gid2",10,100,"cds")); + ll.push_back(Interval("gid3",1000,3000,"cds")); + ll.push_back(Interval("gid4",500,800,"cds")); + ll.push_back(Interval("gid5",200,700,"cds")); + + std::cout << "before create idx" << std::endl; + + Idx = new IntervalTree(ll,16, 2, -1, -1, 3); + + std::cout << "after create idx" << std::endl; + + res = (*Idx).find(20,600); + res_gene = (*Idx).find_gene(20,600); + + for (i = 0; i<res.size(); i++) { + std::cout << res[i].gene << std::endl; + } + + for (i = 0; i<res_gene.size(); i++) { + std::cout << res[i].gene << std::endl; + } +} +*/
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/IntervalTree.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,56 @@ +// +// IntervalTree.h +// BAMQC-0.5 +// +// Created by Ying Jin on 9/15/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_0_5__IntervalTree__ +#define __BAMQC_0_5__IntervalTree__ + +#include <stdio.h> +#include <string> +#include <vector> + +#include "Constants.h" + +class Interval{ +public: + int start; + int stop; + //std::string gene; + int gene; + //std::string type; + int type; + int exon; + + Interval(); + Interval(int g, int exon,int st, int end, int t); + ~Interval(); +}; + + + + + +class IntervalTree{ +public : + std::vector<Interval> itvlist; + IntervalTree* left ; + IntervalTree* right ; + float center ; + + IntervalTree(); + IntervalTree(std::vector<Interval> intervals, int depth = DEPTH, int minbucket= MIN_BUCKET, int extent_st=-1, int extent_end = -1 , int maxbucket= MAX_BUCKET); + ~IntervalTree(); + std::vector<Interval> find(int start, int stop); + std::vector<int> find_gene(int start, int stop); +private: + void clear(IntervalTree * node); + +}; + + + +#endif /* defined(__BAMQC_0_5__IntervalTree__) */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/Mappability.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,326 @@ +// +// Mappablity.cpp +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "Mappability.h" +#include "htslib/sam.h" +//#include <stdio> +#include <iostream> +#include <fstream> + +#include <stdlib.h> +#include <vector> + + +int bam_cigar2mapped_read_len(int n_cigar, const uint32_t *cigar) +{ + int k, l; + for (k = l = 0; k < n_cigar; ++k) + { + if (bam_cigar_op(cigar[k])==BAM_CMATCH) + { l += bam_cigar_oplen(cigar[k]);} + } + return l; +} + +void bam_cigar2Clip(int n_cigar, const uint32_t *cigar,std::vector<std::pair<int, int> > * clip_pos_len) +{ + int k, pos; + + //std::cout << "number of cigar " << n_cigar <<std::endl; + + for (k = pos = 0; k < n_cigar; ++k) + if (bam_cigar_op(cigar[k]) == BAM_CSOFT_CLIP ) + { + clip_pos_len->push_back(std::pair<int,int> (pos,bam_cigar_oplen(cigar[k]))); + pos += bam_cigar_oplen(cigar[k]); + } + else { + if (bam_cigar_op(cigar[k]) == BAM_CMATCH || bam_cigar_op(cigar[k]) == BAM_CINS || bam_cigar_op(cigar[k]) == BAM_CEQUAL || bam_cigar_op(cigar[k]) == BAM_CDIFF ) + { pos += bam_cigar_oplen(cigar[k]);} + } + + return ; +} + + +Clipping_prof::Clipping_prof(std::string outfile_data,std::string outfile_fig,int qcut,int sample_size) +{ + + + clip_data_file = outfile_data + ".clipping_profile.xls"; + clip_script_file = outfile_data + ".clipping_profile.r"; + clip_fig_file = outfile_fig+ ".clipping_profile.png"; + + mapq_fig_file = outfile_fig+ ".mapq_profile.png"; + mapq_data_file = outfile_data + ".mapq_profile.xls"; + mapq_script_file = outfile_data + ".mapq_profile.r"; + + readlen_data_file = outfile_data + ".readlen_profile.xls"; + readlen_fig_file = outfile_fig+ ".readlen_profile.png"; + readlen_script_file = outfile_data + ".ReadLen_plot.r"; + + samplesize = sample_size; + + q_cutoff = qcut; + read_len =0; +} +Clipping_prof::~Clipping_prof(){ + +} +Clipping_prof::Clipping_prof(int mapq,int sample_size){ + q_cutoff = mapq; + samplesize = sample_size; + read_len =0; + +} +int Clipping_prof::get_max_read_len(){ + return this->read_len; +} +void Clipping_prof::write(int total_read) +{ + std::string read_pos =""; + std::string clip_count = ""; + std::string mapq_val = ""; + std::string mapq_count = ""; + std::string readlen_val = ""; + std::string readlen_count = ""; + + int max_mapq = 0; + + if (read_len > MAX_READ_LEN) { + std::cout << "read length greater than 10000." << std::endl; + return; + } + try{ + std::ofstream OUT ; + OUT.open (readlen_data_file, std::ofstream::out); + OUT << "Position\tRead_Total\tRead_Len_mapped\n"; + + //soft_clip_profile[0] = 1; + for(auto& kv : readLen_list ){ + readlen_val += ',' + std::to_string(kv.first); + readlen_count += ',' + std::to_string(kv.second); + + OUT << kv.first << '\t' << total_read << '\t' << kv.second << '\n'; + } + + OUT.close(); + + + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing clipping profile." << std::endl; + return; + } + + try{ + std::ofstream OUT ; + OUT.open (clip_data_file, std::ofstream::out); + OUT << "Position\tRead_Total\tRead_clipped\n"; + + //soft_clip_profile[0] = 1; + for(int i=0; i< read_len; i++ ){ + read_pos += ',' + std::to_string(i); + clip_count += ',' + std::to_string(soft_clip_profile[i]); + + OUT << i << '\t' << total_read << '\t' << soft_clip_profile[i] << '\n'; + } + + OUT.close(); + + + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing clipping profile." << std::endl; + return; + } + try{ + if(read_pos != ""){ + std::ofstream ROUT ; + ROUT.open(clip_script_file,std::ofstream::out); + + ROUT << "png(\"" << clip_fig_file << "\",width=500,height=500,units=\"px\")\n"; + ROUT << "read_pos=c(" << read_pos.substr(1) << ")\n" ; + //ROUT <<'read_pos=read_pos[2:length(read_pos)]\n'; + ROUT << "count=c(" << clip_count.substr(1) << ")\n"; + //ROUT << "count=count[2:length(count)]\n"; + + ROUT << "plot(read_pos,1-(count/" << total_read <<"),pch=20,xlab=\"Position of reads\",ylab=\"Mappability\",col=\"blue\")\n"; + + ROUT << "dev.state=dev.off()\n"; + + ROUT.close(); + } + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing clipping script file." << std::endl; + return; + } + try{ + std::ofstream OUT; + OUT.open(mapq_data_file,std::ofstream::out); + + OUT << "MAPQ\tRead_Total\tRead_with_mapq\n"; + + for(auto& kv :mapqlist ){ + mapq_val += ',' + std::to_string(kv.first); + + mapq_count += ',' + std::to_string(kv.second); + + if (kv.first > max_mapq ){ + max_mapq = kv.first; + } + + OUT << std::to_string(kv.first) + '\t' + std::to_string(total_read) + '\t' + std::to_string(kv.second) +'\n'; + } + OUT.close(); + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing mapping quality profile." << std::endl; + return; + } + + if (mapqlist.size() > 0 ){ + try { + if(mapq_val != ""){ + std::ofstream ROUT; + ROUT.open(mapq_script_file,std::ofstream::out); + + ROUT << "png(\"" << mapq_fig_file << "\",width=500,height=500,units=\"px\")\n"; + ROUT << "mapq_val=c(" << mapq_val.substr(1) << ")\n"; + ROUT<< "mapq_count=c(" << mapq_count.substr(1) << ")\n"; + + ROUT << "xname=c(\"<3\",\"<10\",\"<20\",\"<30\",\"30-" << std::to_string(max_mapq) << "\")\n"; + ROUT <<"freq = rep(0,5)\n"; + + ROUT << "freq[1] = sum(mapq_count[which(mapq_val<3)])/" << std::to_string(total_read) << "*100\n"; + ROUT <<"freq[2] = sum(mapq_count[which(mapq_val<10)])/" << std::to_string(total_read) << "*100\n"; + ROUT << "freq[3] = sum(mapq_count[which(mapq_val<20)])/" << std::to_string(total_read) << "*100\n"; + ROUT << "freq[4] = sum(mapq_count[which(mapq_val<30)])/" << std::to_string(total_read) << "*100\n"; + ROUT<< "freq[5] = 100\n"; + + ROUT << "barplot(freq,beside=T,xlab=\"Mapping Quality\",border=\"NA\",space=1.5,main=\"Mapping Quality\",ylim=c(0,100),ylab=\"Cumulative proportion (%)\",col=\"blue\",names.arg=xname)\n"; + + ROUT << "dev.state=dev.off()\n"; + ROUT.close(); + } + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing mapping quality script file." << std::endl; + return; + } + } + //std::cout << readLen_list.size() << std::endl; + if (readLen_list.size() > 0) { + try { + std::ofstream ROUT; + ROUT.open(readlen_script_file,std::ofstream::out); + + ROUT << "png(\"" << readlen_fig_file << "\",width=500,height=500,units=\"px\")\n"; + ROUT << "readlen_val=c(" << readlen_val.substr(1) << ")\n"; + ROUT<< "readlen_count=c(" << readlen_count.substr(1) << ")\n"; + + ROUT << "plot(readlen_val,(readlen_count/" << total_read <<"),pch=20,xlab=\"Mapped Read Length\",ylab=\"Proportion\",col=\"blue\")\n"; + + ROUT << "dev.state=dev.off()\n"; + ROUT.close(); + + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing mapping quality script file." << std::endl; + return; + } + } +} + +void Clipping_prof::add(Clipping_prof * clip_prof) +{ + for (auto& j : clip_prof->mapqlist){ + std::map<int,int>::iterator it; + it = mapqlist.find(j.first); + + if (it != mapqlist.end()){ + mapqlist[j.first] += j.second; + } + else { + mapqlist[j.first] = j.second; + } + } + + for (int i=0;i< MAX_READ_LEN; i++){ + soft_clip_profile[i] += clip_prof->soft_clip_profile[i]; + } + if (clip_prof->get_max_read_len() > read_len) { + read_len = clip_prof->get_max_read_len(); + } + for (auto& kv : clip_prof->readLen_list){ + std::map<int,int>::iterator it; + it = readLen_list.find(kv.first); + + if (it != readLen_list.end()){ + readLen_list[kv.first] += kv.second; + } + else { + readLen_list[kv.first] = kv.second; + } + } +} + +void Clipping_prof::set_qual(int mapq) +{ + std::map<int,int>::iterator it; + it = mapqlist.find(mapq); + if (it != mapqlist.end()) { + mapqlist[mapq] += 1; + } + else{ + mapqlist[mapq] = 1; + } +} +void Clipping_prof::set(int len,uint32_t n_cigar, uint32_t * cigar,int mapq) +{ + int r = bam_cigar2mapped_read_len(n_cigar,cigar); + //std::cout << "read len " << r << std::endl; + //std::cout << "number of cigar " << n_cigar <<std::endl; + if(read_len < len) + { + read_len = len; + } + std::map<int,int>::iterator it; + it = mapqlist.find(mapq); + if (it != mapqlist.end()) { + mapqlist[mapq] += 1; + } + else{ + mapqlist[mapq] = 1; + } + //std::cout << "after mapq " << mapq << std::endl; + it = readLen_list.find(r); + if(it!=readLen_list.end()){ + readLen_list[r] += 1; + } + else{ + readLen_list[r] = 1; + } + + //std::cout << "after read len " << r << std::endl; + std::vector<std::pair<int, int> > soft_clip_pos_len ; + + bam_cigar2Clip(n_cigar,cigar,&soft_clip_pos_len); + + + //std::cout << "soft clip len " << soft_clip_pos_len.size() << std::endl; + if(soft_clip_pos_len.size() > 0) { + for (auto p : soft_clip_pos_len){ + int pos = p.first; + int len = p.second; + + //std::cout << pos << "\t" << len << std::endl; + for (int j = 0; j< len;j++){ + soft_clip_profile[pos+j] +=1; + } + + } + } + +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/Mappability.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,54 @@ +// +// Mappablity.h +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_c____Mappablity__ +#define __BAMQC_c____Mappablity__ + +#include <stdio.h> +#include <string> +#include "Constants.h" +#include <utility> +#include <map> + +int bam_cigar2mapped_read_len(int n_cigar, const uint32_t *cigar); +class Clipping_prof{ +public: + int q_cutoff; + int samplesize; + + int soft_clip_profile[MAX_READ_LEN]={0}; + std::string clip_data_file; + std::string clip_fig_file; + std::string clip_script_file; + + std::string readlen_data_file; + std::string readlen_script_file; + std::string readlen_fig_file; + + std::string mapq_fig_file; + std::string mapq_data_file; + std::string mapq_script_file; + + std::map<int, int> mapqlist; + std::map<int, int> readLen_list; + + Clipping_prof(int qcut, int sample_size = SAMPLESIZE); + Clipping_prof(std::string data_dir,std::string fig_dir,int qcut, int sample_size = SAMPLESIZE); + + ~Clipping_prof(); + void set(int len,uint32_t n_cigar, uint32_t * cigar,int mapq); + void set_qual(int mapq); + void write(int total_read); + void add(Clipping_prof * clip_prof); + + int get_max_read_len(); +private: + int read_len; +}; + +#endif /* defined(__BAMQC_c____Mappablity__) */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/ReadDup_prof.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,9 @@ +// +// ReadDup_prof.cpp +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "ReadDup_prof.h"
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/ReadDup_prof.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,14 @@ +// +// ReadDup_prof.h +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_c____ReadDup_prof__ +#define __BAMQC_c____ReadDup_prof__ + +#include <stdio.h> + +#endif /* defined(__BAMQC_c____ReadDup_prof__) */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/Results.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,133 @@ +// +// Results.cpp +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include <stdio.h> +#include <iostream> +#include <fstream> +#include <string> + +#include "Results.h" + +Results::Results(){ + +} + +Results::~Results(){ + +} + +void Results::write(std::string fname) +{ + try{ + std::ofstream f; + f.open(fname,std::ofstream::out); + + f << "filename" << "\t" << fname << "\n"; + f << "is_pairEnd" << "\t" << this->is_pairEnd << "\n"; + f << "clipping_plot_file" << "\t" << this->clipping_plot_file << "\n"; + f << "mapq_plot_file"<< "\t" <<this->mapq_plot_file << "\n"; + f << "mapq_file"<< "\t" <<this->mapq_file << "\n"; + f << "read_cov_plot_file"<< "\t" <<this->read_cov_plot_file << "\n"; + f << "trans_cov_plot_file"<< "\t" <<this->trans_cov_plot_file<< "\n"; + f << "insert_plot_file" << "\t" << this->insert_plot_file<< "\n"; + f << "insert_file" << "\t" << this->insert_file<< "\n"; + f << "read_dist_plot_file1" << "\t" << this->read_dist_plot_file1<< "\n"; + f << "read_dist_plot_file2" << "\t" <<this->read_dist_plot_file2<< "\n"; + f << "readLen_plot_file" << "\t" << this->readLen_plot_file<< "\n"; + f << "geneCount_file" << "\t" << this->geneCount_file<< "\n"; + f << "seqDeDup_percent" << "\t" <<std::to_string(this->seqDeDup_percent)<< "\n"; + f << "posDeDup_percent" << "\t" << std::to_string(this->posDeDup_percent)<< "\n"; + f << "no_clipping" << "\t" << this->no_clipping << "\n"; + f << "no_rRNA" << "\t" << this->no_rRNA << "\n"; + f << "total_reads" << "\t" <<std::to_string(this->total_reads) << "\n"; + f << "uniq_mapped_reads" << "\t" <<std::to_string(this->uniq_mapped_reads)<< "\n"; + f << "multi_mapped_reads" << "\t" <<std::to_string(this->multi_mapped_reads)<< "\n"; + f << "unmapped_reads" << "\t" <<std::to_string(this->unmapped_reads)<< "\n"; + f << "low_qual" << "\t" <<std::to_string(this->low_qual)<< "\n"; + f << "low_qual_read1" << "\t" <<std::to_string(this->low_qual_read1)<< "\n"; + f << "low_qual_read2" << "\t" <<std::to_string(this->low_qual_read2)<< "\n"; + f << "pcr_dup" << "\t" <<std::to_string(this->pcr_dup)<< "\n"; + f << "rRNA_read" << "\t" <<std::to_string(this->rRNA_read)<< "\n"; + + f << "cds_read" << "\t" <<std::to_string(this->cds_exon_read)<< "\n"; + f << "utr5_read" << "\t" <<std::to_string(this->utr_5_read)<< "\n"; + f << "utr3_read" << "\t" <<std::to_string(this->utr_3_read)<< "\n"; + f << "intron_read" << "\t" <<std::to_string(this->intron_read)<< "\n"; + f << "itgup1k_read" << "\t" <<std::to_string(this->intergenic_up1kb_read)<< "\n"; + f << "itgdn1k_read" << "\t" <<std::to_string(this->intergenic_down1kb_read)<< "\n"; + f << "itg_read" << "\t" <<std::to_string(this->intergenic_read)<< "\n"; + + + f << "unmapped_read1" << "\t" <<std::to_string(this->unmapped_read1)<< "\n"; + f << "unmapped_read2" << "\t" <<std::to_string(this->unmapped_read2)<< "\n"; + f << "mapped_read1"<< "\t" <<std::to_string(this->mapped_read1)<< "\n"; + f << "mapped_read2"<< "\t" <<std::to_string(this->mapped_read2) << "\n"; + f << "forward_read"<< "\t" <<std::to_string(this->forward_read)<< "\n"; + f << "reverse_read" << "\t" << std::to_string(this->reverse_read)<< "\n"; + f << "paired_reads"<< "\t" << std::to_string(this->paired_reads) + "\n"; + f << "mapped_plus_minus"<< "\t" <<std::to_string(this->mapped_plus_minus) << "\n"; + f << "mapped_plus_plus"<< "\t" <<std::to_string(this->mapped_plus_plus)<< "\n"; + f << "mapped_minus_plus" << "\t" <<std::to_string(this->mapped_minus_plus)<< "\n"; + f << "mapped_minus_minus" << "\t" <<std::to_string(this->mapped_minus_minus)<< "\n"; + f << "ins_read" << "\t" <<std::to_string(this->ins_read)<< "\n"; + f << "del_read"<< "\t" <<std::to_string(this->del_read)<< "\n"; + f << "noSplice"<< "\t" <<std::to_string(this->noSplice)<< "\n"; + f << "splice"<< "\t" <<std::to_string(this->splice)<< "\n"; + f << "paired_diff_chrom" << "\t" <<std::to_string(this->paired_diff_chrom)<< "\n"; + f.close(); + + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing result ." << std::endl; + return; + } + +} + +void Results::add(Results *res){ + + no_clipping = (no_clipping || res->no_clipping); + no_rRNA = (no_rRNA && res->no_rRNA); + + rRNA_read += res->rRNA_read; + total_reads += res->total_reads; + uniq_mapped_reads +=res->uniq_mapped_reads; + multi_mapped_reads +=res->multi_mapped_reads; + unmapped_reads += res->unmapped_reads; + low_qual += res->low_qual; + low_qual_read1 += res->low_qual_read1; + low_qual_read2 += res->low_qual_read2; + pcr_dup += res->pcr_dup; + + unmapped_read1 += res->unmapped_read1; + unmapped_read2 += res->unmapped_read2; + mapped_read1 += res->mapped_read1; + mapped_read2 += res->mapped_read2; + forward_read += res->forward_read; + reverse_read += res->reverse_read; + paired_reads += res->paired_reads; + + mapped_plus_minus += res->mapped_plus_minus; + mapped_plus_plus += res->mapped_plus_plus; + mapped_minus_plus += res->mapped_minus_plus; + mapped_minus_minus += res->mapped_minus_minus; + + ins_read += res->ins_read; + del_read += res->del_read; + + noSplice += res->noSplice; + splice += res->splice; + paired_diff_chrom += res->paired_diff_chrom; + + cds_exon_read += res->cds_exon_read; + utr_5_read += res->utr_5_read; + utr_3_read += res->utr_3_read; + intron_read += res->intron_read; + intergenic_up1kb_read += res->intergenic_up1kb_read; + intergenic_down1kb_read += res->intergenic_down1kb_read; + intergenic_read += res->intergenic_read; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/Results.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,87 @@ +// +// Results.h +// BAMQC_c++ +// +// Created by Ying Jin on 10/28/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef BAMQC_c___Results_h +#define BAMQC_c___Results_h + +#include <string> + + +class Results { + +public: + Results(); + ~Results(); + void add(Results *res); + void write(std::string fname); + + std::string filename = ""; + + std::string clipping_plot_file = ""; + std::string mapq_plot_file = ""; + std::string mapq_file = ""; + std::string read_cov_plot_file = "";; + std::string trans_cov_plot_file = ""; + std::string insert_plot_file = ""; + std::string insert_file = ""; + std::string read_dist_plot_file1 = ""; + std::string read_dist_plot_file2 = ""; + std::string read_dup_plot_file = ""; + std::string readLen_plot_file = ""; + std::string geneCount_file = ""; + + double seqDeDup_percent = 0; + double posDeDup_percent = 0; + bool is_pairEnd = false; + + bool no_clipping = false; + bool no_rRNA = false; + + + int total_reads = 0; + int uniq_mapped_reads = 0; + int multi_mapped_reads = 0; + int unmapped_reads = 0; + int low_qual = 0; + int low_qual_read1 = 0; + int low_qual_read2 = 0; + int pcr_dup = 0; + int rRNA_read = 0; + + int cds_exon_read =0; + int utr_5_read =0; + int utr_3_read =0; + int intron_read =0; + int intergenic_up1kb_read =0; + int intergenic_down1kb_read = 0; + int intergenic_read = 0; + + int unmapped_read1 = 0; + int unmapped_read2 = 0; + int mapped_read1 = 0; + int mapped_read2 = 0; + int forward_read = 0; + int reverse_read = 0; + int paired_reads = 0; + + int mapped_plus_minus = 0; + int mapped_plus_plus = 0; + int mapped_minus_plus = 0; + int mapped_minus_minus = 0; + + int ins_read = 0; + int del_read = 0; + + int noSplice = 0; + int splice = 0; + int paired_diff_chrom = 0; + +}; + + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/parseBAM.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1055 @@ +// +// parseBAM.cpp +// BAMQC_c++ +// +// Created by Ying Jin on 11/11/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "parseBAM.h" +#include "Coverage_prof.h" +#include "GeneFeatures.h" +#include "InnerDist_prof.h" +#include "Mappability.h" +#include "Results.h" +#include "rRNA.h" +#include "Constants.h" + +//#include <malloc.h> +#include <string> +#include <stdlib.h> +#include <pthread.h> +//#include <stdio.h> +#include <iostream> +#include <fstream> +#include <unistd.h> + +#include "htslib/sam.h" + + + +unsigned int tick_time =3000; + +#define IS_PAIRED(bam) ((bam)->core.flag&BAM_FPAIRED) +#define IS_QCFAIL(bam) ((bam)->core.flag & BAM_FQCFAIL) + +#define IS_PAIRED_AND_MAPPED(bam) (((bam)->core.flag&BAM_FPAIRED) && !((bam)->core.flag&BAM_FUNMAP) && !((bam)->core.flag&BAM_FMUNMAP)) + +#define IS_PROPERLYPAIRED(bam) (((bam)->core.flag&(BAM_FPAIRED|BAM_FPROPER_PAIR)) == (BAM_FPAIRED|BAM_FPROPER_PAIR) && !((bam)->core.flag&BAM_FUNMAP)) + +#define IS_UNMAPPED(bam) ((bam)->core.flag&BAM_FUNMAP) +#define IS_REVERSE(bam) ((bam)->core.flag&BAM_FREVERSE) +#define IS_MATE_REVERSE(bam) ((bam)->core.flag&BAM_FMREVERSE) +#define IS_READ1(bam) ((bam)->core.flag&BAM_FREAD1) +#define IS_READ2(bam) ((bam)->core.flag&BAM_FREAD2) +#define IS_DUP(bam) ((bam)->core.flag&BAM_FDUP) +//#defind READ_NAME(bam) (bam_get_qname(bam)) + +/*DEF BAM_CMATCH = 0 +DEF BAM_CINS = 1 +DEF BAM_CDEL = 2 +DEF BAM_CREF_SKIP = 3 +DEF BAM_CSOFT_CLIP = 4 +DEF BAM_CHARD_CLIP = 5 +DEF BAM_CPAD = 6 +DEF BAM_CEQUAL = 7 +DEF BAM_CDIFF = 8*/ + +typedef struct +{ + bam1_t * first; + bam1_t * second; + int type; +} read_pair_t ; + +typedef struct +{ + unsigned short thread_id; + pthread_t thread_object; + //pthread_spinlock_t cur_reads_lock; + pthread_spinlock_t cur_reads_lock; + + //std::vector<std::pair<bam1_t *,bam1_t *> > *cur_reads; + std::vector<read_pair_t> * cur_reads; + + Results * res; + InnerDist_prof * inDist_prof; + Clipping_prof * clip_prof; + Coverage_prof * cov_prof; + +} thread_context_t; + +typedef struct +{ + unsigned short thread_number; + int all_finished; + std::string format; + std::string stranded; + //bam_hdr_t * header; + std::vector<std::string> refnames; + std::vector<thread_context_t *> thread_contexts; + + GeneFeatures * geneIdx; + rRNA * rRNAIdx; + +} global_context_t; + +struct arg_struct { + global_context_t * arg1; + thread_context_t * arg2; +}; +std::vector<std::pair<int, int> > fetch_intron(int st, uint32_t * cigar, uint32_t n_cigar,std::string format) +{ + //''' fetch intron regions defined by cigar. st must be zero based return list of tuple of (st, end)''' + //match = re.compile(r'(\d+)(\D)') + int chrom_st = st; + if (format == "BAM") { chrom_st += 1 ;} + + std::vector<std::pair<int,int> > intron_bound ; + + for (unsigned int i=0; i < n_cigar; i++){ //code and size + if (bam_cigar_op(cigar[i])==BAM_CMATCH) { chrom_st += bam_cigar_oplen(cigar[i]);} //match + if (bam_cigar_op(cigar[i])==BAM_CINS) {continue;} //insertion + if (bam_cigar_op(cigar[i])==BAM_CDEL) { chrom_st += bam_cigar_oplen(cigar[i]);} //deletion + if (bam_cigar_op(cigar[i])==BAM_CREF_SKIP) { intron_bound.push_back(std::pair<int,int> (chrom_st,chrom_st+ bam_cigar_oplen(cigar[i])-1)); } //gap + if (bam_cigar_op(cigar[i])==BAM_CSOFT_CLIP) { chrom_st += bam_cigar_oplen(cigar[i]);}// soft clipping + } + + return intron_bound ; +} + +std::vector<std::pair<int, int> > fetch_exon(int st,uint32_t * cigar,uint32_t n_cigar,std::string format) +{ + //''' fetch exon regions defined by cigar. st must be zero based return list of tuple of (st, end)''' + //match = re.compile(r'(\d+)(\D)') + int chrom_st = st; + if (format == "BAM") { chrom_st += 1;} + + std::vector<std::pair<int,int> >exon_bound; + + for (unsigned int i=0; i < n_cigar; i++){ //code and size + if (bam_cigar_op(cigar[i])==BAM_CMATCH) { exon_bound.push_back(std::pair<int, int> (chrom_st,chrom_st + bam_cigar_oplen(cigar[i])-1));} //match + if (bam_cigar_op(cigar[i])==BAM_CINS) {continue;} //insertion + if (bam_cigar_op(cigar[i])==BAM_CDEL) { chrom_st += bam_cigar_oplen(cigar[i]);} //deletion + if (bam_cigar_op(cigar[i])==BAM_CREF_SKIP) { chrom_st += bam_cigar_oplen(cigar[i]); } //gap + if (bam_cigar_op(cigar[i])==BAM_CSOFT_CLIP) { chrom_st += bam_cigar_oplen(cigar[i]);}// soft clipping + } + return exon_bound; +} + + +std::pair<int, int> ovp_gene( GeneFeatures * geneIdx,std::string chrom1,std::vector<std::pair<int,int> >exon_blocks1,std::string chrom2,std::vector<std::pair<int, int> > exon_blocks2,std::string strand,std::vector<int> * mapped_exons) +{ + std::map<int,int> res1 = geneIdx->Gene_annotation(chrom1,exon_blocks1,strand,mapped_exons); + std::map<int,int> res2 = geneIdx->Gene_annotation(chrom2,exon_blocks2,strand,mapped_exons); + if(res2.size() == 0) + { + if(res1.size() ==0 ) { return std::pair<int,int>(-1,-1);} + if(res1.size() == 1) { return std::pair<int,int>(res1.begin()->second,res1.begin()->first);} + std::map<int,std::vector<int> > type_gene_list; + int min_type = 6; + int second_min_type = 6; + for(auto& kv : res1){ + if(type_gene_list.find(kv.second) != type_gene_list.end()) + { + type_gene_list[kv.second].push_back(kv.first); + } + else { + std::vector<int> tmp; + tmp.push_back(kv.first); + type_gene_list.insert(std::pair<int,std::vector<int> >(kv.second,tmp)); + } + if(kv.second < min_type ) {min_type = kv.second; second_min_type = min_type;} + } + if(type_gene_list[min_type].size() == 1 && min_type <= 3 && second_min_type > 3) + { return std::pair<int,int> (min_type,type_gene_list[min_type][0]); } + return std::pair<int,int>(min_type,-1); + } + if(res1.size() == 0) + { + if(res2.size() ==0 ) { return std::pair<int,int>(-1,-1);} + if(res2.size() == 1) { return std::pair<int,int>(res2.begin()->second,res2.begin()->first);} + std::map<int,std::vector<int> > type_gene_list; + int min_type = 6; + int second_min_type = 6; + for(auto& kv : res2){ + if(type_gene_list.find(kv.second) != type_gene_list.end()) + { + type_gene_list[kv.second].push_back(kv.first); + } + else { + std::vector<int> tmp; + tmp.push_back(kv.first); + type_gene_list.insert(std::pair<int,std::vector<int> >(kv.second,tmp)); + } + if(kv.second < min_type ) {min_type = kv.second; second_min_type = min_type;} + } + if(type_gene_list[min_type].size() == 1 && min_type <= 3 && second_min_type > 3) + { return std::pair<int,int> (min_type,type_gene_list[min_type][0]); } + return std::pair<int,int>(min_type,-1); + } + //PE + if (res1.size() ==1 && res2.size() ==1 ){ + int g1 = res1.begin()->first; + int type1 = res1.begin()->second; + int g2 = res2.begin()->first; + int type2 = res2.begin()->second; + if(g1 == g2) { + if(type1 < type2) { return std::pair<int,int> (type1,g1); } + else { return std::pair<int,int> (type2,g1); } + }else { + if(type1 < type2) { return std::pair<int,int> (type1,-1); } + else { return std::pair<int,int> (type2,-1); } + } + } + if (res1.size() > 1 || res2.size() > 1 ) + { + std::vector<int> ovp_genes ; + + for(auto& kv : res1 ) + { + if(res2.find(kv.first)!=res2.end()) { + ovp_genes.push_back(kv.first); + } + } + if(ovp_genes.size() == 1) { + if(res1[ovp_genes[0]] < res2[ovp_genes[0]]) { return std::pair<int,int> (res1[ovp_genes[0]],ovp_genes[0]); } + else { return std::pair<int,int> (res2[ovp_genes[0]],ovp_genes[0]); } + } + if (ovp_genes.size() > 1) { + std::map<int,std::vector<int> > type_gene_list; + int min_type = 6; + int second_min_type = 6; + for(auto g : ovp_genes){ + int type1 = res1[g]; + int type2 = res2[g]; + int type = type1; + if (type2 < type1) { + type = type2; + } + if(type_gene_list.find(type) != type_gene_list.end()) + { + type_gene_list[type].push_back(g); + } + else { + std::vector<int> tmp; + tmp.push_back(g); + type_gene_list.insert(std::pair<int,std::vector<int> >(type,tmp)); + } + if(type < min_type ) {min_type = type; second_min_type = min_type;} + } + if(type_gene_list[min_type].size() == 1 && min_type <= 3 && second_min_type > 3) + { return std::pair<int,int> (min_type,type_gene_list[min_type][0]); } + else { return std::pair<int,int>(min_type,-1); } + + } + + if (ovp_genes.size() == 0) { + std::map<int,std::vector<int> > type_gene_list; + int min_type = 6; + int second_min_type = 6; + for (auto& kv : res1) { + if(type_gene_list.find(kv.second) != type_gene_list.end()) + { + type_gene_list[kv.second].push_back(kv.first); + } + else { + std::vector<int> tmp; + tmp.push_back(kv.first); + type_gene_list.insert(std::pair<int,std::vector<int> >(kv.second,tmp)); + } + if(kv.second < min_type ) {min_type = kv.second; second_min_type = min_type;} + } + for(auto& kv : res2){ + if(type_gene_list.find(kv.second) != type_gene_list.end()) + { + type_gene_list[kv.second].push_back(kv.first); + } + else { + std::vector<int> tmp; + tmp.push_back(kv.first); + type_gene_list.insert(std::pair<int,std::vector<int> >(kv.second,tmp)); + } + if(kv.second < min_type ) {min_type = kv.second; second_min_type = min_type;} + } + if(type_gene_list[min_type].size() == 1 && min_type <= 3 && second_min_type > 3) + { return std::pair<int,int> (min_type,type_gene_list[min_type][0]); } + else { return std::pair<int,int>(min_type,-1); } + + + } + + } + + return std::pair<int, int> (-1,-1); + +} + +//void process_aligned_fragment(global_context_t * global_context,thread_context_t * thread_context,std::pair<bam1_t *,bam1_t *> read_pair) +void process_aligned_fragment(global_context_t * global_context,thread_context_t * thread_context,read_pair_t read_pair) +{ + + bam1_t * cur_read1 = read_pair.first; + bam1_t * cur_read2 = read_pair.second; + std::string strand1 = "."; + std::string strand2 = "."; + int chrom1_id = -1; + int chrom2_id = -1; + std::vector<std::pair<int, int> > exons1 ; + std::vector<std::pair<int, int> > exons2 ; + std::vector<std::pair<int, int> > intron_blocks1 ; + std::vector<std::pair<int, int> > intron_blocks2 ; + std::string qname = ""; + std::string chrom1 = ""; + std::string chrom2 = ""; + + if(cur_read1 != NULL ) { + if(!IS_UNMAPPED(cur_read1)) + { + uint32_t *cigar = bam_get_cigar(cur_read1); + char * name = bam_get_qname(cur_read1); + + if (read_pair.type == 0) { //only for uniq-read + thread_context-> clip_prof->set(cur_read1->core.l_qseq,cur_read1->core.n_cigar,cigar,cur_read1->core.qual); + } + chrom1_id = cur_read1->core.tid; + + qname = std::string(name); + if((size_t)cur_read1->core.tid < global_context->refnames.size()){ + chrom1 = global_context->refnames[cur_read1->core.tid]; + } + else { + std::cout << (size_t)cur_read1->core.tid << "\t" << "missing reference sequences." << std::endl; + std::exit(1); + } + + strand1 = IS_REVERSE(cur_read1) ? "-" : "+"; + + if (global_context->stranded =="reverse") { + strand1 = (strand1 == "+") ? "-" : "+"; + } + exons1 = fetch_exon(cur_read1->core.pos, cigar,cur_read1->core.n_cigar, global_context->format); + intron_blocks1 = fetch_intron(cur_read1->core.pos,cigar,cur_read1->core.n_cigar,global_context->format); + } + } + if(cur_read2 != NULL){ + if(! IS_UNMAPPED(cur_read2)){ + uint32_t *cigar = bam_get_cigar(cur_read2); + if (read_pair.type ==0) { + thread_context->clip_prof->set(cur_read2->core.l_qseq,cur_read2->core.n_cigar,cigar,cur_read2->core.qual); + } + strand2 = IS_REVERSE(cur_read2) ? "-" : "+"; + + if (global_context-> stranded =="reverse") { + strand2 = ( strand2 == "+") ? "-" : "+"; + } + chrom2_id = cur_read2->core.tid; + if((size_t)cur_read2->core.tid < global_context->refnames.size()){ + chrom2 = global_context->refnames[cur_read2->core.tid]; + } + else { + std::cout << (size_t)cur_read2->core.tid << "\t" <<"missing reference sequences." << std::endl; + std::exit(1); + } + exons2 = fetch_exon(cur_read2->core.pos, cigar,cur_read2->core.n_cigar, global_context->format); + intron_blocks2 = fetch_intron(cur_read2->core.pos,cigar,cur_read2->core.n_cigar,global_context->format); + } + } + + if (cur_read1 == NULL || IS_UNMAPPED(cur_read1)) { + strand1 = (strand2 == "-") ? "+" : "-"; + } + std::string strand = strand1; + if (global_context->stranded == "no"){ + strand = "."; + } + + //type =1 means multi-read. rRNA read + if (read_pair.type == 1) { + + //std::cout << chrom1 << "\t" << chrom2 << std::endl; + + if (global_context->rRNAIdx != NULL){ + if (global_context->rRNAIdx->is_rRNA(chrom1,exons1,strand) || global_context->rRNAIdx->is_rRNA(chrom2,exons2,strand)){ + thread_context->res->rRNA_read += 1; + //std::cout << qname << std::endl; + if(cur_read1 != NULL){ + bam_destroy1(cur_read1); + } + if(cur_read2 != NULL){ + bam_destroy1(cur_read2); + } + return; + } + } + } + else { //uniq read + + + if (intron_blocks1.size() + intron_blocks2.size() == 0){ + thread_context->res->noSplice += 1; + } + else { + thread_context->res->splice += 1; + } + //paired read + if (chrom1_id != -1 && chrom2_id != -1){ + thread_context->res->paired_reads += 1; + + if (strand1 == "-" && strand2 == "-" ){ + thread_context->res->mapped_minus_minus += 1; + } + if (strand1 == "+" && strand2 == "+" ){ + thread_context->res->mapped_plus_plus += 1; + } + if (strand1 == "+" && strand2 == "-" ){ + thread_context->res->mapped_plus_minus += 1; + } + if (strand1 == "-" && strand2 == "+"){ + thread_context->res->mapped_minus_plus += 1; + } + if (chrom1_id != chrom2_id ){ + thread_context->res->paired_diff_chrom += 1; + if(cur_read1 != NULL){ + bam_destroy1(cur_read1); + } + if(cur_read2 != NULL){ + bam_destroy1(cur_read2); + } + return; + } + } + + //mapped read len + //rRNA read + if (global_context->rRNAIdx != NULL){ + if (global_context->rRNAIdx->is_rRNA(chrom1,exons1,strand) || global_context->rRNAIdx->is_rRNA(chrom2,exons2,strand)){ + thread_context->res->rRNA_read += 1; + //std::cout << qname << std::endl; + if(cur_read1 != NULL){ + bam_destroy1(cur_read1); + } + if(cur_read2 != NULL){ + bam_destroy1(cur_read2); + } + return; + } + } + //cur_time = time.time() + std::vector<int> * mapped_exons = new std::vector<int>(); + + std::pair<int,int> ovp = ovp_gene(global_context->geneIdx,chrom1,exons1,chrom2,exons2,strand,mapped_exons); + switch(ovp.first) + { + case CDS: + thread_context->res->cds_exon_read +=1; + break; + case UTR5: + thread_context->res->utr_5_read +=1; + break; + case UTR3: + thread_context->res->utr_3_read +=1; + break; + case INTRON: + thread_context->res->intron_read +=1; + ovp.second = -1; + break; + case ITGUP1K: + thread_context->res->intergenic_up1kb_read +=1; + ovp.second = -1; + break; + case ITGDN1K: + thread_context->res->intergenic_down1kb_read +=1; + ovp.second = -1; + break; + default: + thread_context->res->intergenic_read +=1; + break; + } + thread_context->cov_prof->count(ovp.second,exons1,exons2,*mapped_exons); + if(chrom1 != "" && chrom2 != ""){ + if( IS_PROPERLYPAIRED(cur_read1)){ + if (strand1 == "+" || strand1 == "."){ + if (global_context->stranded == "reverse") { + thread_context->inDist_prof->count(global_context->geneIdx,ovp.first,cur_read2,chrom2,intron_blocks2,strand1); + } + else{ + thread_context->inDist_prof->count(global_context->geneIdx,ovp.first,cur_read1,chrom1,intron_blocks1,strand1); + } + } + else { + if (global_context->stranded == "reverse" ){ + thread_context->inDist_prof->count(global_context->geneIdx,ovp.first,cur_read1,chrom1,intron_blocks1,strand1); + } + else { + thread_context->inDist_prof->count(global_context->geneIdx,ovp.first,cur_read2,chrom2,intron_blocks2,strand1); + } + } + } + } + delete mapped_exons; + if(cur_read1 != NULL){ + bam_destroy1(cur_read1); + } + if(cur_read2 != NULL){ + bam_destroy1(cur_read2); + } + }//uniq read +} + +void* worker(void * vargs) +{ + struct arg_struct * args = (struct arg_struct *) vargs; + thread_context_t * thread_context = args->arg2; + global_context_t * global_context = args->arg1; + delete args; + + while (1){ + //std::pair<bam1_t *, bam1_t *> cur_read_pair; + read_pair_t cur_read_pair; + while(1){ + int is_retrieved = 0; + pthread_spin_lock(&thread_context->cur_reads_lock); + + if(thread_context->cur_reads->size()>0){ + cur_read_pair = thread_context->cur_reads->back(); + thread_context->cur_reads->pop_back(); + + is_retrieved = 1; + } + pthread_spin_unlock(&thread_context->cur_reads_lock); + if(global_context->all_finished && !is_retrieved) return NULL; + + if(is_retrieved) break; + else usleep(tick_time); + } + process_aligned_fragment(global_context,thread_context,cur_read_pair); + + } +} + + +//start threads +void init_thread(global_context_t * global_context,unsigned short threadNumber,int mapq) +{ + global_context->thread_number = threadNumber; + //global_context -> thread_contexts = (thread_context_t * ) malloc(sizeof(thread_context_t) * global_context -> thread_number); + if(threadNumber >1){ + for(int i=0;i<threadNumber;i++) + { + thread_context_t *th_contx = new thread_context_t(); + pthread_spin_init(&th_contx->cur_reads_lock, PTHREAD_PROCESS_PRIVATE); + th_contx->thread_id = i; + // th_contx->cur_reads = new std::vector<std::pair<bam1_t *,bam1_t *> >() ; + + th_contx->cur_reads = new std::vector<read_pair_t> (); + + th_contx->res = new Results(); + th_contx->clip_prof = new Clipping_prof(mapq); + th_contx->cov_prof = new Coverage_prof(global_context->geneIdx); + th_contx->inDist_prof = new InnerDist_prof(); + global_context->thread_contexts.push_back(th_contx); + } + + for(int i=0;i<threadNumber;i++) + { + struct arg_struct * args = new arg_struct(); + args->arg1 = global_context; + args->arg2 = global_context->thread_contexts[i]; + //int ret = pthread_create(&global_context -> thread_contexts[i].thread_object, NULL, worker, (void *)&args); + pthread_create(&global_context -> thread_contexts[i]->thread_object, NULL, worker, (void *)args); + } + } + else { + thread_context_t *th_contx = new thread_context_t(); + //th_contx->cur_reads = new std::vector<std::pair<bam1_t *,bam1_t *> >() ; + th_contx->cur_reads = new std::vector<read_pair_t> (); + + th_contx->res = new Results(); + th_contx->clip_prof = new Clipping_prof(mapq); + th_contx->cov_prof = new Coverage_prof(global_context->geneIdx); + th_contx->inDist_prof = new InnerDist_prof(); + global_context->thread_contexts.push_back(th_contx); + + } + + return; +} + +//release memory +void destroy_thread_context(global_context_t * global_context) +{ + + for(int i=0; i < global_context-> thread_number; i++) + { + delete global_context->thread_contexts[i]->res; + delete global_context->thread_contexts[i]->cov_prof; + delete global_context->thread_contexts[i]->clip_prof; + delete global_context->thread_contexts[i]->cur_reads; + delete global_context->thread_contexts[i]->inDist_prof; + if(global_context->thread_number >1){ + pthread_spin_destroy(&global_context -> thread_contexts[i]->cur_reads_lock); + } + delete global_context -> thread_contexts[i]; + } + +} + +//join threads +void join_threads(global_context_t * global_context) +{ + int xk1; + for(xk1=0; xk1<global_context-> thread_number; xk1++) + pthread_join(global_context -> thread_contexts[xk1]->thread_object, NULL); +} + +//merge results +void merge_results(global_context_t * global_context,Results * res,Clipping_prof * clip_prof,Coverage_prof * cov_prof, InnerDist_prof * inDist_prof) +{ + for(int i=0;i<global_context->thread_number;i++) + { + res->add(global_context->thread_contexts[i]->res); + clip_prof->add(global_context->thread_contexts[i]->clip_prof); + cov_prof->add(global_context->thread_contexts[i]->cov_prof); + inDist_prof->add(global_context->thread_contexts[i]->inDist_prof); + } +} + +// parsing BAM file +Results QC(std::string smp_name,GeneFeatures * geneIdx, rRNA * rRNAIdx,char * inputFile,std::string outdir,std::string outdir_fig,std::string stranded,int threadNumber,int mapq) +{ + //'''This class provides fuctions to parsing SAM or BAM files and quality controls.''' + //'''constructor. input could be bam or sam''' + + int q_cut = mapq; + global_context_t global_context; + global_context.stranded = stranded; + global_context.all_finished = 0; + + //open SAM/BAM file + samFile *fp_in = NULL; + bam1_t * aligned_read = NULL; + bam_hdr_t *header = NULL; + + std::string format = "BAM"; + + fp_in = sam_open(inputFile, "rb"); + + if(NULL == fp_in) { + std::cout << "Could not open file " << inputFile << std::endl; + std::exit(1); + } + if(hts_get_format(fp_in)->format == sam) {format = "SAM";} + global_context.format = format; + + aligned_read = bam_init1(); + + Results main_res; + //read header + header = sam_hdr_read(fp_in); + if(NULL == header){ + std::cout << "No header information." << std::endl; + std::exit(1); + } + for(int i=0;i< header->n_targets;i++) + { + char * p = header->target_name[i]; + std::string chr(p); + global_context.refnames.push_back(chr); + } + //return main_res; + + std::string prev_read_id = ""; + std::vector<bam1_t *> multi_read1; + std::vector<bam1_t *> multi_read2; + + std::vector<bam1_t *> alignments_per_read; + + + Clipping_prof main_clip_prof(outdir+smp_name,outdir_fig+smp_name,mapq); + Coverage_prof main_cov_prof(outdir+smp_name,outdir_fig+smp_name,geneIdx); + //ReadDup_prof main_rDup_prof(outdir,outdir_fig); + InnerDist_prof main_inDist_prof(outdir+smp_name,outdir_fig+smp_name); + + int lineno = 0; + global_context.geneIdx = geneIdx; + global_context.rRNAIdx = rRNAIdx; + init_thread(&global_context, threadNumber,mapq); + + int current_thread_id = 0; + + while(sam_read1(fp_in, header,aligned_read) > 0) + { + lineno +=1 ; + //std::cout << lineno << std::endl; + + std::string qname =""; + char * name = bam_get_qname(aligned_read); + if(name !=NULL) + { + qname = std::string(name); + } + //SE reads + if (! IS_PAIRED(aligned_read)) + { + //count unmapped read + if (IS_UNMAPPED(aligned_read)) + { + main_res.unmapped_reads += 1; + main_res.total_reads += 1; + bam_destroy1(aligned_read); + aligned_read = bam_init1(); + continue; + } + + if (qname == prev_read_id || prev_read_id == "") { + alignments_per_read.push_back(aligned_read); + prev_read_id = qname; + aligned_read = bam_init1(); + continue; + } + else { + bam1_t *cur_read = NULL; + if (alignments_per_read.size() == 1){ //unique read + main_res.uniq_mapped_reads += 1; + main_res.total_reads += 1; + + cur_read = alignments_per_read[0]; + + int skip_read = 0; + + if (cur_read->core.flag & BAM_FQCFAIL || cur_read->core.qual < q_cut){ //skip QC fail read + main_clip_prof.set_qual(cur_read->core.qual); + main_res.low_qual += 1; + skip_read = 1; + } + if (IS_DUP(cur_read)){ //skip duplicate read + skip_read = 1; + } + if (skip_read == 1) { + bam_destroy1(cur_read); + cur_read = NULL; + } + if (cur_read ){ + if (IS_REVERSE(cur_read)) {main_res.reverse_read += 1;} + else {main_res.forward_read += 1;} + read_pair_t read_pair; // = new read_pair_t(); + read_pair.first = cur_read; + read_pair.second = NULL; + read_pair.type = 0; + + if(global_context.thread_number >1){ + + thread_context_t * thread_context = global_context.thread_contexts[current_thread_id]; + pthread_spin_lock(&thread_context->cur_reads_lock); + + //thread_context->cur_reads->push_back(std::pair<bam1_t *,bam1_t *>(cur_read,NULL)); + thread_context->cur_reads->push_back(read_pair); + + pthread_spin_unlock(&thread_context->cur_reads_lock); + current_thread_id++; + if(current_thread_id >= global_context.thread_number) current_thread_id = 0; + } + else { + // process_aligned_fragment(&global_context,global_context.thread_contexts[0],std::pair<bam1_t *,bam1_t *> (cur_read,NULL)); + process_aligned_fragment(&global_context,global_context.thread_contexts[0],read_pair); + } + } + + } + else { //multi reads + main_res.multi_mapped_reads += 1; + main_res.total_reads += 1; + cur_read = alignments_per_read[0]; + //check whether it's rRNA read using only one of the multialignments + main_clip_prof.set_qual(cur_read->core.qual); + + //for(unsigned int i=0;i<alignments_per_read.size();i++){ + for(unsigned int i=1;i<alignments_per_read.size();i++){ + bam_destroy1(alignments_per_read[i]); + } + //cur_read = NULL; + read_pair_t read_pair; // = new read_pair_t(); + read_pair.first = cur_read; + read_pair.second = NULL; + read_pair.type = 1; + + if(global_context.thread_number >1){ + //thread_context_t * thread_context = global_context.thread_contexts + current_thread_id; + thread_context_t * thread_context = global_context.thread_contexts[current_thread_id]; + pthread_spin_lock(&thread_context->cur_reads_lock); + + thread_context->cur_reads->push_back(read_pair); + //thread_context->cur_reads->push_back(std::pair<bam1_t *,bam1_t *>(cur_read,NULL)); + pthread_spin_unlock(&thread_context->cur_reads_lock); + current_thread_id++; + if(current_thread_id >= global_context.thread_number) current_thread_id = 0; + } + else { + //process_aligned_fragment(&global_context,global_context.thread_contexts[0],std::pair<bam1_t *,bam1_t *> (cur_read,NULL)); + process_aligned_fragment(&global_context,global_context.thread_contexts[0],read_pair); + + } + } + alignments_per_read.clear(); + alignments_per_read.push_back(aligned_read); + prev_read_id = qname; + aligned_read = bam_init1(); + } + } + else {//pair end read + main_res.is_pairEnd = true; + size_t flag_pos = qname.find('/'); + //cur_read_id = aligned_read.qname; + if (flag_pos != std::string::npos) {qname = qname.substr(0,flag_pos);} + + if (qname == prev_read_id ){ + if (IS_READ1(aligned_read) ){ multi_read1.push_back(aligned_read);} + if (IS_READ2(aligned_read) ){multi_read2.push_back(aligned_read);} + aligned_read = bam_init1(); + continue; + } + else { + bam1_t * cur_read1 = NULL; + bam1_t * cur_read2 = NULL; + main_res.total_reads += 1; + + //multi-reads + if (multi_read1.size() >1 || multi_read2.size() > 1){ + main_res.multi_mapped_reads += 1; + read_pair_t read_pair; + read_pair.first = NULL; + read_pair.second = NULL; + read_pair.type = 1; + + if (multi_read1.size() > 1 ){ + main_clip_prof.set_qual(multi_read1[0]->core.qual); + read_pair.first = multi_read1[0]; + } + if (multi_read2.size() > 1 ){ + main_clip_prof.set_qual(multi_read2[0]->core.qual); + read_pair.second = multi_read2[0]; + } + //for(unsigned int i=0;i< multi_read1.size();i++) + for(unsigned int i=1;i< multi_read1.size();i++) + { + bam_destroy1(multi_read1[i]); + } + //for(unsigned int i=0;i< multi_read2.size();i++) + for(unsigned int i=1;i< multi_read2.size();i++) + { + bam_destroy1(multi_read2[i]); + } + //read_pair_t * read_pair = new read_pair_t(); + + + if(global_context.thread_number > 1){ + //thread_context_t * thread_context = global_context.thread_contexts + current_thread_id; + thread_context_t * thread_context = global_context.thread_contexts[current_thread_id]; + + pthread_spin_lock(&thread_context->cur_reads_lock); + + //thread_context->cur_reads->push_back(std::pair<bam1_t *,bam1_t *>(cur_read1,cur_read2)); + thread_context->cur_reads->push_back(read_pair); + + pthread_spin_unlock(&thread_context->cur_reads_lock); + current_thread_id++; + if(current_thread_id >= global_context.thread_number) + current_thread_id = 0; + } + else { + //process_aligned_fragment(&global_context,global_context.thread_contexts[0],std::pair<bam1_t *,bam1_t *> (cur_read1,cur_read2)); + process_aligned_fragment(&global_context,global_context.thread_contexts[0],read_pair); + } + } + else { + //uniq read + if (multi_read1.size() == 1) {cur_read1 = multi_read1[0];} + if (multi_read2.size() == 1){ cur_read2 = multi_read2[0];} + + if (cur_read1 && !IS_UNMAPPED(cur_read1)){ + + if ( cur_read1->core.flag & BAM_FQCFAIL || cur_read1->core.qual < q_cut ){ + main_clip_prof.set_qual(cur_read1->core.qual); + bam_destroy1(cur_read1); + cur_read1 = NULL; + main_res.low_qual_read1 += 1; + } + else { + main_res.mapped_read1 += 1; + if (IS_REVERSE(cur_read1)){ main_res.reverse_read += 1;} + else{ main_res.forward_read +=1;} + } + } + else { + if(cur_read1) { bam_destroy1(cur_read1); cur_read1 = NULL;} + if (prev_read_id != ""){ main_res.unmapped_read1 += 1; } + } + + if (cur_read2 && !IS_UNMAPPED(cur_read2)){ + + if (cur_read2->core.flag & BAM_FQCFAIL || cur_read2->core.qual < q_cut){ + main_clip_prof.set_qual(cur_read2->core.qual); + main_res.low_qual_read2 += 1; + bam_destroy1(cur_read2); + cur_read2 = NULL; + } + else { + main_res.mapped_read2 += 1; + if (!cur_read1){ + if (!IS_REVERSE(cur_read2)){ main_res.reverse_read += 1;} + else{ main_res.forward_read +=1;} + } + } + } + else { + if(cur_read2) {bam_destroy1(cur_read2); cur_read2 = NULL;} + if (prev_read_id != ""){ // #not the first fragment + main_res.unmapped_read2 += 1;} + } + + if (cur_read1 || cur_read2 ){ + //read_pair_t * read_pair = new read_pair_t(); + read_pair_t read_pair; + read_pair.first = cur_read1; + read_pair.second = cur_read2; + read_pair.type = 0; + + if(global_context.thread_number > 1){ + //thread_context_t * thread_context = global_context.thread_contexts + current_thread_id; + thread_context_t * thread_context = global_context.thread_contexts[current_thread_id]; + + pthread_spin_lock(&thread_context->cur_reads_lock); + + //thread_context->cur_reads->push_back(std::pair<bam1_t *,bam1_t *>(cur_read1,cur_read2)); + thread_context->cur_reads->push_back(read_pair); + + pthread_spin_unlock(&thread_context->cur_reads_lock); + current_thread_id++; + if(current_thread_id >= global_context.thread_number) + current_thread_id = 0; + } + else { + //process_aligned_fragment(&global_context,global_context.thread_contexts[0],std::pair<bam1_t *,bam1_t *> (cur_read1,cur_read2)); + process_aligned_fragment(&global_context,global_context.thread_contexts[0],read_pair); + } + } + } + multi_read1.clear(); + multi_read2.clear(); + prev_read_id = qname; + if (IS_READ1(aligned_read)){ + multi_read1.push_back(aligned_read);} + if (IS_READ2(aligned_read)){ + multi_read2.push_back(aligned_read);} + } + + aligned_read = bam_init1(); + } + } + bam_destroy1(aligned_read); + bam_hdr_destroy(header); + sam_close(fp_in); + global_context.all_finished = 1; + //join threads + if(global_context.thread_number >1) + { + join_threads(&global_context); + } + merge_results(&global_context,&main_res,&main_clip_prof,&main_cov_prof,&main_inDist_prof); + destroy_thread_context(&global_context); + + + main_res.splice = int(main_res.splice); + main_res.noSplice = int(main_res.noSplice); + + if (main_res.is_pairEnd ){ + main_clip_prof.write(main_res.total_reads*2-main_res.unmapped_read1-main_res.unmapped_read2); + } + else { + main_clip_prof.write(main_res.total_reads); + } + + //main_rDup_prof.write(); + main_inDist_prof.write(); + int zero_exons = main_cov_prof.write(main_res.total_reads); + + main_res.read_dist_plot_file1 = outdir_fig +smp_name+ ".read_distr.png"; + main_res.read_dist_plot_file2 = outdir_fig + smp_name + ".read_distr_pie.png"; + + //std::cout << main_res.rRNA_read << std::endl; + try { + std::ofstream ROUT; + + ROUT.open (outdir +smp_name+ ".read_distr.r", std::ofstream::out); + //ROUT = fopen(outfile + '.read_distr.r', 'w') + ROUT << "png(\"" << main_res.read_dist_plot_file1 << "\",width=500,height=500,units=\"px\")\n"; + ROUT << "M=c(" << std::to_string(main_res.cds_exon_read) << "," << std::to_string(main_res.utr_5_read) << "," << std::to_string(main_res.utr_3_read) << "," << std::to_string(main_res.intron_read) << "," << std::to_string(main_res.intergenic_up1kb_read) << "," << std::to_string(main_res.intergenic_down1kb_read) << "," << std::to_string(main_res.rRNA_read) << "," << std::to_string(main_res.intergenic_read) << ")\n"; + + ROUT << "Mname=c(\"CDS\",\"5UTR\",\"3UTR\",\"Intron\",\"TSS_Up_1Kb\",\"TES_Down_1Kb\",\"rRNA\",\"Others\")\n"; + ROUT << "val = barplot(M,xlab=\"\",space=1,ylab=\"Read Counts\",col=\"blue\",border=\"NA\")\n"; + ROUT << "text(x=seq(val[1],val[8],by=2),y=rep(0,8),srt=60,adj=0,offset=2,pos=1,xpd=T,labels=Mname)\n"; + ROUT << "dev.state = dev.off()\n"; + ROUT.close(); + + ROUT.open(outdir + smp_name+".read_distr_pie.r", std::ofstream::out); + if (geneIdx->total_exon != 0 ){ + ROUT << "png(\"" << main_res.read_dist_plot_file2 << "\",width=500,height=500,units=\"px\")\n"; + ROUT << "pie(c(" << std::to_string(geneIdx->total_exon-zero_exons) << ',' << std::to_string(zero_exons) << "),labels=c(\"Covered " << (geneIdx->total_exon - zero_exons) << " exons\",\"Uncovered\"),main=\"Exons\",radius=0.6,clockwise=T,col=c(\"blue\",\"white\"))\n"; + ROUT << "dev.state = dev.off()\n"; + } + ROUT.close(); + }catch(std::ofstream::failure e ){ + std::cout << "Error in writing plotting scripts.\n" << std::endl; + } + + main_res.insert_plot_file = main_inDist_prof.InnDist_fig_file; + main_res.insert_file = main_inDist_prof.InnDist_data_file; + + main_res.clipping_plot_file = main_clip_prof.clip_fig_file; + main_res.mapq_plot_file = main_clip_prof.mapq_fig_file; + main_res.mapq_file = main_clip_prof.mapq_data_file; + + //res.read_dup_plot_file = rDup_prof.plot_file + main_res.readLen_plot_file = main_clip_prof.readlen_fig_file; + + main_res.read_cov_plot_file = main_cov_prof.cov_fig_file; + main_res.geneCount_file = main_cov_prof.transcov_data_file; + main_res.trans_cov_plot_file = main_cov_prof.transcov_fig_file; + //res.seqDeDup_percent = rDup_prof.seqDeDup_percent + //res.posDeDup_percent = rDup_prof.posDeDup_percent + return main_res; +} + +int run_qc(char* out_dir, char* outfig_dir,char * ann_file, char* attrID, char* input_file,char* rRNA_file,char* label,int mapq,char* stranded,int thread_num) +{ + std::string gtf_fname (ann_file); + std::string id_attrID (attrID); + //std::string ifile (input_file); + std::string smp_name (label); + std::string strand_info (stranded); + std::string data_outdir (out_dir); + std::string fig_outdir (outfig_dir); + std::string smp_res_fname = data_outdir+smp_name+".res.txt"; + + //int thread_num = 1; + + std::string rRNA_fname (rRNA_file); + rRNA * rRNAIdx = NULL; + + GeneFeatures * geneIdx = new GeneFeatures(gtf_fname,id_attrID); + if (rRNA_fname != "") { + rRNAIdx = new rRNA(rRNA_fname); + } + Results res = QC(smp_name,geneIdx,rRNAIdx,input_file,data_outdir,fig_outdir,strand_info,thread_num,mapq); + + res.write(smp_res_fname); + + delete geneIdx; + delete rRNAIdx; + + return 1; +} + + +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/parseBAM.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,17 @@ +// +// parseBAM.h +// BAMQC_c++ +// +// Created by Ying Jin on 11/18/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_c____parseBAM__ +#define __BAMQC_c____parseBAM__ + +#include <stdio.h> + +extern "C" { +int run_qc(char* out_dir, char* outfig_dir,char * ann_file, char* attrID, char* input_file,char* rRNA_file,char* label,int maqp,char* stranded,int threadNum); +} +#endif /* defined(__BAMQC_c____parseBAM__) */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/rRNA.cpp Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,230 @@ +// +// GeneFeatures.cpp +// BAMQC-0.5 +// +// Created by Ying Jin on 9/15/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#include "rRNA.h" +#include "Constants.h" + +#include <cmath> +#include <fstream> +#include <sstream> +//#include <regex> +#include "stdlib.h" +#include <algorithm> +#include <iostream> + + +rRNA::rRNA(std::string rRNAfilename){ + + read_features(rRNAfilename); + +} + +rRNA::~rRNA(){ + std::map<std::string,IntervalTree *>::iterator it; + + for (it=featureIdxs_plus.begin(); it != featureIdxs_plus.end(); it++) { + IntervalTree *tmp = it->second; + delete tmp; + + } + for (it=featureIdxs_minus.begin(); it != featureIdxs_minus.end(); it++) { + IntervalTree *tmp = it->second; + delete tmp; + } + +} + +//Reading & processing annotation files +void rRNA::read_features(std::string rRNA_filename) +{ + + //dict of dicts since the builtin type doesn't support it for some reason + std::map<std::string, std::vector<Interval> > temp_plus ; + std::map<std::string, std::vector<Interval> > temp_minus ; + std::map<std::string, std::vector<Interval> >::iterator tmp_itr; + + int i = 0; + //int counts = 0 ; + int line_no = 0; + int start; + int end; + int idx = 0; + + std::ifstream input; //(gff_filename); + + try{ + input.open (rRNA_filename, std::ifstream::in); + + while(! input.eof()){ + + std::string line,chrom,feature,start_ss,end_ss,score,strand; + std::stringstream ss; + + if (! std::getline(input,line)){ break; } + line_no ++; + + if (line == "\n" || !line.compare(0,1,"#")) { continue; } + + ss << line; + std::getline(ss,chrom,'\t'); + std::getline(ss,start_ss,'\t'); + std::getline(ss,end_ss,'\t'); + std::getline(ss,feature,'\t'); + std::getline(ss,score,'\t'); + std::getline(ss,strand,'\t'); + + try{ + start = std::stol(start_ss); + end = std::stol(end_ss); + } + catch (const std::invalid_argument& ia) { + std::cerr << "Invalid argument: " << ia.what() << '\n'; + std::exit(1); + + } + + if (strand == "+" ){ + tmp_itr = temp_plus.find(chrom); + if (tmp_itr != temp_plus.end()) { + std::vector<Interval> *tmp_ptr = &(tmp_itr->second); + //(*tmp_ptr).push_back(Interval(feature,-1,start,end,"rRNA")); + (*tmp_ptr).push_back(Interval(idx,-1,start,end,RRNA)); + idx++; + } + else{ + std::vector<Interval> tmp ; + tmp.push_back(Interval(idx,-1,start,end,RRNA)); + + temp_plus.insert(std::pair<std::string,std::vector<Interval> >(chrom,tmp)); + idx++; + } + } + + if (strand == "-" ) { + + tmp_itr = temp_minus.find(chrom); + if (tmp_itr != temp_minus.end()) { + std::vector<Interval> *tmp_ptr = &(tmp_itr->second); + (*tmp_ptr).push_back(Interval(idx,-1,start,end,RRNA)); + idx++; + } + else{ + std::vector<Interval> tmp ; + tmp.push_back(Interval(idx,-1,start,end,RRNA)); + + temp_minus.insert(std::pair<std::string,std::vector<Interval> >(chrom,tmp)); + idx++; + } + } + + i += 1 ; + if (i % 100000 == 0 ) + { + //sys.stderr.write("%d GTF lines processed.\n" % i); + std::cout << i << " rRNA lines processed." << std::endl; + } + + } + + input.close(); + } + catch(std::ifstream::failure e){ + std::cout << "error in read file " << rRNA_filename << std::endl; + } + //build interval trees + + + for (tmp_itr = temp_plus.begin(); tmp_itr != temp_plus.end(); tmp_itr++) { + std::string chr = tmp_itr->first; + std::vector<Interval> itemlist = tmp_itr->second; + + std::sort(itemlist.begin(),itemlist.end(),itv_comp) ; + + featureIdxs_plus[chr] = new IntervalTree(itemlist); + } + + for (tmp_itr = temp_minus.begin(); tmp_itr != temp_minus.end(); tmp_itr++) { + std::string chr = tmp_itr->first; + + std::vector<Interval> itemlist = tmp_itr->second; + + std::sort(itemlist.begin(),itemlist.end(),itv_comp) ; + + featureIdxs_minus[chr] = new IntervalTree(itemlist); + } + + +} + +//find exons of given gene that overlap with the given intervals +//return list of tuples +bool rRNA::is_rRNA(std::string chrom, std::vector<std::pair<int,int> > itv_list,std::string strand) +{ + std::vector<std::string> rRNAs; + std::vector<Interval> fs ; + std::map<std::string, IntervalTree*>::iterator chrom_it; + size_t i; + if (strand == "+" || strand == ".") { + chrom_it = featureIdxs_plus.find(chrom); + if (chrom_it != featureIdxs_plus.end()) { + + for (i=0; i < itv_list.size(); i ++) { + //std::cout << "start to search tree" << std::endl; + fs = (*featureIdxs_plus[chrom]).find(itv_list[i].first,itv_list[i].second); + //} + } + } + } + + if (strand == "-" or strand == ".") { + chrom_it = featureIdxs_minus.find(chrom); + if (chrom_it != featureIdxs_minus.end()) { + + for (i=0; i < itv_list.size(); i ++) { + std::vector<Interval> tmp = (*featureIdxs_minus[chrom]).find(itv_list[i].first,itv_list[i].second); + + fs.insert(fs.end(),tmp.begin(),tmp.end()); + } + + } + } + + //std::cout << fs.size() << std::endl; + if (fs.size() > 0 ) { + return true; + } + else{ + return false; + } + +} +/* +int main() { + std::string filename = "./test.bed"; + std::string id_attr = "gene_id"; + + std::vector<chr_ITV> itv_list ; + chr_ITV exp ; + exp.chrom = "chr1"; + exp.start = 11870; + exp.end = 73220; + itv_list.push_back(exp); + + std::cout << "start to build tree " << std::endl; + rRNA gIdx (filename); + std::cout << "after build tree " << std::endl; + + // for (int i=0; i < itv_list.size(); i++) { + // std::cout << itv_list[i].start << std::endl; + //} + bool res = gIdx.is_rRNA(itv_list,"."); + //for (int i=0;i<res.size(); i++) { + std::cout << res << std::endl; + //} + +}*/
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/rRNA.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,41 @@ +// +// rRNA.h +// BAMQC-0.5 +// +// Created by Ying Jin on 9/15/15. +// Copyright (c) 2015 Ying Jin. All rights reserved. +// + +#ifndef __BAMQC_0_5__rRNA__ +#define __BAMQC_0_5__rRNA__ + +#include <stdio.h> +#include <string.h> +#include <vector> +#include <map> +#include <utility> + +#include "IntervalTree.h" +#include "GeneFeatures.h" + + +class rRNA{ + +public: + + std::map<std::string, IntervalTree *> featureIdxs_plus ; + std::map<std::string, IntervalTree *> featureIdxs_minus ; + + rRNA(std::string rRNAfilename); + ~rRNA(); + + bool is_rRNA(std::string chrom,std::vector<std::pair<int,int> > itv_list,std::string strand); + +private: + void read_features(std::string rRNA_filename) ; + //void build_tree(std::map<std::string, std::map<std::string,Gene> > temp_plus, std::map<std::string, std::map<std::string,Gene> > temp_minus); + +}; + + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/ezBAMQC/sam.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,426 @@ +/* sam.h -- SAM and BAM file I/O and manipulation. + + Copyright (C) 2008, 2009, 2013-2014 Genome Research Ltd. + Copyright (C) 2010, 2012, 2013 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_SAM_H +#define HTSLIB_SAM_H + +#include <stdint.h> +#include "hts.h" + +/********************** + *** SAM/BAM header *** + **********************/ + +/*! @typedef + @abstract Structure for the alignment header. + @field n_targets number of reference sequences + @field l_text length of the plain text in the header + @field target_len lengths of the reference sequences + @field target_name names of the reference sequences + @field text plain text + @field sdict header dictionary + */ + +typedef struct { + int32_t n_targets, ignore_sam_err; + uint32_t l_text; + uint32_t *target_len; + int8_t *cigar_tab; + char **target_name; + char *text; + void *sdict; +} bam_hdr_t; + +/**************************** + *** CIGAR related macros *** + ****************************/ + +#define BAM_CMATCH 0 +#define BAM_CINS 1 +#define BAM_CDEL 2 +#define BAM_CREF_SKIP 3 +#define BAM_CSOFT_CLIP 4 +#define BAM_CHARD_CLIP 5 +#define BAM_CPAD 6 +#define BAM_CEQUAL 7 +#define BAM_CDIFF 8 +#define BAM_CBACK 9 + +#define BAM_CIGAR_STR "MIDNSHP=XB" +#define BAM_CIGAR_SHIFT 4 +#define BAM_CIGAR_MASK 0xf +#define BAM_CIGAR_TYPE 0x3C1A7 + +#define bam_cigar_op(c) ((c)&BAM_CIGAR_MASK) +#define bam_cigar_oplen(c) ((c)>>BAM_CIGAR_SHIFT) +#define bam_cigar_opchr(c) (BAM_CIGAR_STR[bam_cigar_op(c)]) +#define bam_cigar_gen(l, o) ((l)<<BAM_CIGAR_SHIFT|(o)) + +/* bam_cigar_type returns a bit flag with: + * bit 1 set if the cigar operation consumes the query + * bit 2 set if the cigar operation consumes the reference + * + * For reference, the unobfuscated truth table for this function is: + * BAM_CIGAR_TYPE QUERY REFERENCE + * -------------------------------- + * BAM_CMATCH 1 1 + * BAM_CINS 1 0 + * BAM_CDEL 0 1 + * BAM_CREF_SKIP 0 1 + * BAM_CSOFT_CLIP 1 0 + * BAM_CHARD_CLIP 0 0 + * BAM_CPAD 0 0 + * BAM_CEQUAL 1 1 + * BAM_CDIFF 1 1 + * BAM_CBACK 0 0 + * -------------------------------- + */ +#define bam_cigar_type(o) (BAM_CIGAR_TYPE>>((o)<<1)&3) // bit 1: consume query; bit 2: consume reference + +/*! @abstract the read is paired in sequencing, no matter whether it is mapped in a pair */ +#define BAM_FPAIRED 1 +/*! @abstract the read is mapped in a proper pair */ +#define BAM_FPROPER_PAIR 2 +/*! @abstract the read itself is unmapped; conflictive with BAM_FPROPER_PAIR */ +#define BAM_FUNMAP 4 +/*! @abstract the mate is unmapped */ +#define BAM_FMUNMAP 8 +/*! @abstract the read is mapped to the reverse strand */ +#define BAM_FREVERSE 16 +/*! @abstract the mate is mapped to the reverse strand */ +#define BAM_FMREVERSE 32 +/*! @abstract this is read1 */ +#define BAM_FREAD1 64 +/*! @abstract this is read2 */ +#define BAM_FREAD2 128 +/*! @abstract not primary alignment */ +#define BAM_FSECONDARY 256 +/*! @abstract QC failure */ +#define BAM_FQCFAIL 512 +/*! @abstract optical or PCR duplicate */ +#define BAM_FDUP 1024 +/*! @abstract supplementary alignment */ +#define BAM_FSUPPLEMENTARY 2048 + +/************************* + *** Alignment records *** + *************************/ + +/*! @typedef + @abstract Structure for core alignment information. + @field tid chromosome ID, defined by bam_hdr_t + @field pos 0-based leftmost coordinate + @field bin bin calculated by bam_reg2bin() + @field qual mapping quality + @field l_qname length of the query name + @field flag bitwise flag + @field n_cigar number of CIGAR operations + @field l_qseq length of the query sequence (read) + @field mtid chromosome ID of next read in template, defined by bam_hdr_t + @field mpos 0-based leftmost coordinate of next read in template + */ +typedef struct { + int32_t tid; + int32_t pos; + uint32_t bin:16, qual:8, l_qname:8; + uint32_t flag:16, n_cigar:16; + int32_t l_qseq; + int32_t mtid; + int32_t mpos; + int32_t isize; +} bam1_core_t; + +/*! @typedef + @abstract Structure for one alignment. + @field core core information about the alignment + @field l_data current length of bam1_t::data + @field m_data maximum length of bam1_t::data + @field data all variable-length data, concatenated; structure: qname-cigar-seq-qual-aux + + @discussion Notes: + + 1. qname is zero tailing and core.l_qname includes the tailing '\0'. + 2. l_qseq is calculated from the total length of an alignment block + on reading or from CIGAR. + 3. cigar data is encoded 4 bytes per CIGAR operation. + 4. seq is nybble-encoded according to bam_nt16_table. + */ +typedef struct { + bam1_core_t core; + int l_data, m_data; + uint8_t *data; +#ifndef BAM_NO_ID + uint64_t id; +#endif +} bam1_t; + +/*! @function + @abstract Get whether the query is on the reverse strand + @param b pointer to an alignment + @return boolean true if query is on the reverse strand + */ +#define bam_is_rev(b) (((b)->core.flag&BAM_FREVERSE) != 0) +/*! @function + @abstract Get whether the query's mate is on the reverse strand + @param b pointer to an alignment + @return boolean true if query's mate on the reverse strand + */ +#define bam_is_mrev(b) (((b)->core.flag&BAM_FMREVERSE) != 0) +/*! @function + @abstract Get the name of the query + @param b pointer to an alignment + @return pointer to the name string, null terminated + */ +#define bam_get_qname(b) ((char*)(b)->data) +/*! @function + @abstract Get the CIGAR array + @param b pointer to an alignment + @return pointer to the CIGAR array + + @discussion In the CIGAR array, each element is a 32-bit integer. The + lower 4 bits gives a CIGAR operation and the higher 28 bits keep the + length of a CIGAR. + */ +#define bam_get_cigar(b) ((uint32_t*)((b)->data + (b)->core.l_qname)) +/*! @function + @abstract Get query sequence + @param b pointer to an alignment + @return pointer to sequence + + @discussion Each base is encoded in 4 bits: 1 for A, 2 for C, 4 for G, + 8 for T and 15 for N. Two bases are packed in one byte with the base + at the higher 4 bits having smaller coordinate on the read. It is + recommended to use bam_seqi() macro to get the base. + */ +#define bam_get_seq(b) ((b)->data + ((b)->core.n_cigar<<2) + (b)->core.l_qname) +/*! @function + @abstract Get query quality + @param b pointer to an alignment + @return pointer to quality string + */ +#define bam_get_qual(b) ((b)->data + ((b)->core.n_cigar<<2) + (b)->core.l_qname + (((b)->core.l_qseq + 1)>>1)) +/*! @function + @abstract Get auxiliary data + @param b pointer to an alignment + @return pointer to the concatenated auxiliary data + */ +#define bam_get_aux(b) ((b)->data + ((b)->core.n_cigar<<2) + (b)->core.l_qname + (((b)->core.l_qseq + 1)>>1) + (b)->core.l_qseq) +/*! @function + @abstract Get length of auxiliary data + @param b pointer to an alignment + @return length of the concatenated auxiliary data + */ +#define bam_get_l_aux(b) ((b)->l_data - ((b)->core.n_cigar<<2) - (b)->core.l_qname - (b)->core.l_qseq - (((b)->core.l_qseq + 1)>>1)) +/*! @function + @abstract Get a base on read + @param s Query sequence returned by bam_get_seq() + @param i The i-th position, 0-based + @return 4-bit integer representing the base. + */ +#define bam_seqi(s, i) ((s)[(i)>>1] >> ((~(i)&1)<<2) & 0xf) + +/************************** + *** Exported functions *** + **************************/ + +#ifdef __cplusplus +extern "C" { +#endif + + /*************** + *** BAM I/O *** + ***************/ + + bam_hdr_t *bam_hdr_init(void); + bam_hdr_t *bam_hdr_read(BGZF *fp); + int bam_hdr_write(BGZF *fp, const bam_hdr_t *h); + void bam_hdr_destroy(bam_hdr_t *h); + int bam_name2id(bam_hdr_t *h, const char *ref); + bam_hdr_t* bam_hdr_dup(const bam_hdr_t *h0); + + bam1_t *bam_init1(void); + void bam_destroy1(bam1_t *b); + int bam_read1(BGZF *fp, bam1_t *b); + int bam_write1(BGZF *fp, const bam1_t *b); + bam1_t *bam_copy1(bam1_t *bdst, const bam1_t *bsrc); + bam1_t *bam_dup1(const bam1_t *bsrc); + + int bam_cigar2qlen(int n_cigar, const uint32_t *cigar); + int bam_cigar2rlen(int n_cigar, const uint32_t *cigar); + + /*! + @abstract Calculate the rightmost base position of an alignment on the + reference genome. + + @param b pointer to an alignment + @return the coordinate of the first base after the alignment, 0-based + + @discussion For a mapped read, this is just b->core.pos + bam_cigar2rlen. + For an unmapped read (either according to its flags or if it has no cigar + string), we return b->core.pos + 1 by convention. + */ + int32_t bam_endpos(const bam1_t *b); + + int bam_str2flag(const char *str); /** returns negative value on error */ + char *bam_flag2str(int flag); /** The string must be freed by the user */ + + /************************* + *** BAM/CRAM indexing *** + *************************/ + + // These BAM iterator functions work only on BAM files. To work with either + // BAM or CRAM files use the sam_index_load() & sam_itr_*() functions. + #define bam_itr_destroy(iter) hts_itr_destroy(iter) + #define bam_itr_queryi(idx, tid, beg, end) sam_itr_queryi(idx, tid, beg, end) + #define bam_itr_querys(idx, hdr, region) sam_itr_querys(idx, hdr, region) + #define bam_itr_next(htsfp, itr, r) hts_itr_next((htsfp)->fp.bgzf, (itr), (r), 0) + + // Load .csi or .bai BAM index file. + #define bam_index_load(fn) hts_idx_load((fn), HTS_FMT_BAI) + + int bam_index_build(const char *fn, int min_shift); + + // Load BAM (.csi or .bai) or CRAM (.crai) index file. + hts_idx_t *sam_index_load(htsFile *fp, const char *fn); + + #define sam_itr_destroy(iter) hts_itr_destroy(iter) + hts_itr_t *sam_itr_queryi(const hts_idx_t *idx, int tid, int beg, int end); + hts_itr_t *sam_itr_querys(const hts_idx_t *idx, bam_hdr_t *hdr, const char *region); + #define sam_itr_next(htsfp, itr, r) hts_itr_next((htsfp)->fp.bgzf, (itr), (r), (htsfp)) + + /*************** + *** SAM I/O *** + ***************/ + + #define sam_open(fn, mode) (hts_open((fn), (mode))) + #define sam_close(fp) hts_close(fp) + + int sam_open_mode(char *mode, const char *fn, const char *format); + + typedef htsFile samFile; + bam_hdr_t *sam_hdr_parse(int l_text, const char *text); + bam_hdr_t *sam_hdr_read(samFile *fp); + int sam_hdr_write(samFile *fp, const bam_hdr_t *h); + + int sam_parse1(kstring_t *s, bam_hdr_t *h, bam1_t *b); + int sam_format1(const bam_hdr_t *h, const bam1_t *b, kstring_t *str); + int sam_read1(samFile *fp, bam_hdr_t *h, bam1_t *b); + int sam_write1(samFile *fp, const bam_hdr_t *h, const bam1_t *b); + + /************************************* + *** Manipulating auxiliary fields *** + *************************************/ + + uint8_t *bam_aux_get(const bam1_t *b, const char tag[2]); + int32_t bam_aux2i(const uint8_t *s); + double bam_aux2f(const uint8_t *s); + char bam_aux2A(const uint8_t *s); + char *bam_aux2Z(const uint8_t *s); + + void bam_aux_append(bam1_t *b, const char tag[2], char type, int len, uint8_t *data); + int bam_aux_del(bam1_t *b, uint8_t *s); + +#ifdef __cplusplus +} +#endif + +/************************** + *** Pileup and Mpileup *** + **************************/ + +#if !defined(BAM_NO_PILEUP) + +/*! @typedef + @abstract Structure for one alignment covering the pileup position. + @field b pointer to the alignment + @field qpos position of the read base at the pileup site, 0-based + @field indel indel length; 0 for no indel, positive for ins and negative for del + @field level the level of the read in the "viewer" mode + @field is_del 1 iff the base on the padded read is a deletion + @field is_head ??? + @field is_tail ??? + @field is_refskip ??? + @field aux ??? + + @discussion See also bam_plbuf_push() and bam_lplbuf_push(). The + difference between the two functions is that the former does not + set bam_pileup1_t::level, while the later does. Level helps the + implementation of alignment viewers, but calculating this has some + overhead. + */ +typedef struct { + bam1_t *b; + int32_t qpos; + int indel, level; + uint32_t is_del:1, is_head:1, is_tail:1, is_refskip:1, aux:28; +} bam_pileup1_t; + +typedef int (*bam_plp_auto_f)(void *data, bam1_t *b); + +struct __bam_plp_t; +typedef struct __bam_plp_t *bam_plp_t; + +struct __bam_mplp_t; +typedef struct __bam_mplp_t *bam_mplp_t; + +#ifdef __cplusplus +extern "C" { +#endif + + /** + * bam_plp_init() - sets an iterator over multiple + * @func: see mplp_func in bam_plcmd.c in samtools for an example. Expected return + * status: 0 on success, -1 on end, < -1 on non-recoverable errors + * @data: user data to pass to @func + */ + bam_plp_t bam_plp_init(bam_plp_auto_f func, void *data); + void bam_plp_destroy(bam_plp_t iter); + int bam_plp_push(bam_plp_t iter, const bam1_t *b); + const bam_pileup1_t *bam_plp_next(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp); + const bam_pileup1_t *bam_plp_auto(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp); + void bam_plp_set_maxcnt(bam_plp_t iter, int maxcnt); + void bam_plp_reset(bam_plp_t iter); + + bam_mplp_t bam_mplp_init(int n, bam_plp_auto_f func, void **data); + /** + * bam_mplp_init_overlaps() - if called, mpileup will detect overlapping + * read pairs and for each base pair set the base quality of the + * lower-quality base to zero, thus effectively discarding it from + * calling. If the two bases are identical, the quality of the other base + * is increased to the sum of their qualities (capped at 200), otherwise + * it is multiplied by 0.8. + */ + void bam_mplp_init_overlaps(bam_mplp_t iter); + void bam_mplp_destroy(bam_mplp_t iter); + void bam_mplp_set_maxcnt(bam_mplp_t iter, int maxcnt); + int bam_mplp_auto(bam_mplp_t iter, int *_tid, int *_pos, int *n_plp, const bam_pileup1_t **plp); + +#ifdef __cplusplus +} +#endif + +#endif // ~!defined(BAM_NO_PILEUP) + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/INSTALL Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,79 @@ +Basic Installation +================== + +To build and install HTSlib, 'cd' to the htslib-1.x directory containing +the package's source and type the following commands: + + ./configure + make + make install + +The './configure' command checks your build environment and allows various +optional functionality to be enabled (see Configuration below). If you +don't want to select any optional functionality, you may wish to omit +configure and just type 'make; make install' as for previous versions +of HTSlib. However if the build fails you should run './configure' as +it can diagnose the common reasons for build failures. + +The 'make' command builds the HTSlib library and and various useful +utilities: bgzip, htsfile, and tabix. If compilation fails you should +run './configure' as it can diagnose problems with your build environment +that cause build failures. + +The 'make install' command installs the libraries, library header files, +utilities, several manual pages, and a pkgconfig file to /usr/local. +The installation location can be changed by configuring with --prefix=DIR +or via 'make prefix=DIR install' (see Installation Locations below). + + +Configuration +============= + +By default, './configure' examines your build environment, checking for +requirements such as the zlib development files, and arranges for a plain +HTSlib build. The following configure options can be used to enable +various features and specify further optional external requirements: + +--with-irods[=DIR] + Specifies the location of the iRODS client library to use to enable + access to data objects stored in iRODS (<http://irods.org/>) via file + paths like 'irods:DATAOBJ'. DIR is the base of an iRODS source tree + such that the library is present as DIR/lib/core/obj/libRodsAPI.* and + headers are present under DIR/lib/api/include and so on. If '=DIR' is + omitted, $IRODS_HOME will be used as a base directory. + +The configure script also accepts the usual options and environment variables +for tuning installation locations and compilers: type './configure --help' +for details. For example, + + ./configure CC=icc --prefix=/opt/icc-compiled + +would specify that HTSlib is to be built with icc and installed into bin, +lib, etc subdirectories under /opt/icc-compiled. + + +Installation Locations +====================== + +By default, 'make install' installs HTSlib libraries under /usr/local/lib, +HTSlib header files under /usr/local/include, utility programs under +/usr/local/bin, etc. (To be precise, the header files are installed within +a fixed 'htslib' subdirectory under the specified .../include location.) + +You can specify a different location to install HTSlib by configuring +with --prefix=DIR or specify locations for particular parts of HTSlib by +configuring with --libdir=DIR and so on. Type './configure --help' for +the full list of such install directory options. + +Alternatively you can specify different locations at install time by +typing 'make prefix=DIR install' or 'make libdir=DIR install' and so on. +Consult the list of prefix/exec_prefix/etc variables near the top of the +Makefile for the full list of such variables that can be overridden. + +You can also specify a staging area by typing 'make DESTDIR=DIR install', +possibly in conjunction with other --prefix or prefix=DIR settings. +For example, + + make DESTDIR=/tmp/staging prefix=/opt + +would install into bin, lib, etc subdirectories under /tmp/staging/opt.
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/LICENSE Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,69 @@ +[Files in this distribution outwith the cram/ subdirectory are distributed +according to the terms of the following MIT/Expat license.] + +The MIT/Expat License + +Copyright (C) 2012-2014 Genome Research Ltd. + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. + + +[Files within the cram/ subdirectory in this distribution are distributed +according to the terms of the following Modified 3-Clause BSD license.] + +The Modified-BSD License + +Copyright (C) 2012-2014 Genome Research Ltd. + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + +1. Redistributions of source code must retain the above copyright notice, + this list of conditions and the following disclaimer. + +2. Redistributions in binary form must reproduce the above copyright notice, + this list of conditions and the following disclaimer in the documentation + and/or other materials provided with the distribution. + +3. Neither the names Genome Research Ltd and Wellcome Trust Sanger Institute + nor the names of its contributors may be used to endorse or promote products + derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" +AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE +IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR ITS CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + + +[The use of a range of years within a copyright notice in this distribution +should be interpreted as being equivalent to a list of years including the +first and last year specified and all consecutive years between them. + +For example, a copyright notice that reads "Copyright (C) 2005, 2007-2009, +2011-2012" should be interpreted as being identical to a notice that reads +"Copyright (C) 2005, 2007, 2008, 2009, 2011, 2012" and a copyright notice +that reads "Copyright (C) 2005-2012" should be interpreted as being identical +to a notice that reads "Copyright (C) 2005, 2006, 2007, 2008, 2009, 2010, +2011, 2012".]
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/Makefile Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,386 @@ +# Makefile for htslib, a C library for high-throughput sequencing data formats. +# +# Copyright (C) 2013-2015 Genome Research Ltd. +# +# Author: John Marshall <jm18@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +CC = gcc +AR = ar +RANLIB = ranlib + +CPPFLAGS = -I. +# TODO: probably update cram code to make it compile cleanly with -Wc++-compat +CFLAGS = -g -Wall -O2 +EXTRA_CFLAGS_PIC = -fPIC +LDFLAGS = +LDLIBS = + +# For now these don't work too well as samtools also needs to know to +# add -lbz2 and -llzma if linking against the static libhts.a library. +# TODO This needs configury and adding to htslib.pc.in. +# +# # Bzip2 support; optionally used by CRAM. +# HAVE_LIBBZ2 := $(shell echo -e "\#include <bzlib.h>\012int main(void){return 0;}" > .test.c && $(CC) $(CFLAGS) $(CPPFLAGS) -o .test .test.c -lbz2 2>/dev/null && echo yes) +# ifeq "$(HAVE_LIBBZ2)" "yes" +# CPPFLAGS += -DHAVE_LIBBZ2 +# LDLIBS += -lbz2 +# endif +# +# # Lzma support; optionally used by CRAM. +# HAVE_LIBLZMA := $(shell echo -e "\#include <lzma.h>\012int main(void){return 0;}" > .test.c && $(CC) $(CFLAGS) $(CPPFLAGS) -o .test .test.c -llzma 2>/dev/null && echo yes) +# ifeq "$(HAVE_LIBLZMA)" "yes" +# CPPFLAGS += -DHAVE_LIBLZMA +# LDLIBS += -llzma +# endif + +prefix = /usr/local +exec_prefix = $(prefix) +bindir = $(exec_prefix)/bin +includedir = $(prefix)/include +libdir = $(exec_prefix)/lib +datarootdir = $(prefix)/share +mandir = $(datarootdir)/man +man1dir = $(mandir)/man1 +man5dir = $(mandir)/man5 +pkgconfigdir= $(libdir)/pkgconfig + +MKDIR_P = mkdir -p +INSTALL = install -p +INSTALL_PROGRAM = $(INSTALL) +INSTALL_DATA = $(INSTALL) -m 644 +INSTALL_DIR = $(MKDIR_P) -m 755 + +BUILT_PROGRAMS = \ + bgzip \ + htsfile \ + tabix + +BUILT_TEST_PROGRAMS = \ + test/fieldarith \ + test/hfile \ + test/sam \ + test/test-regidx \ + test/test_view \ + test/test-vcf-api \ + test/test-vcf-sweep + +all: lib-static lib-shared $(BUILT_PROGRAMS) $(BUILT_TEST_PROGRAMS) + +HTSPREFIX = +include htslib_vars.mk + +lib-static: libhts.a + +# $(shell), :=, and ifeq/.../endif are GNU Make-specific. If you don't have +# GNU Make, comment out the parts of this conditional that don't apply. +PLATFORM := $(shell uname -s) +ifeq "$(PLATFORM)" "Darwin" +SHLIB_FLAVOUR = dylib +lib-shared: libhts.dylib +else +SHLIB_FLAVOUR = so +lib-shared: libhts.so +endif + + +PACKAGE_VERSION = 1.2.1 +LIBHTS_SOVERSION = 1 + + +# $(NUMERIC_VERSION) is for items that must have a numeric X.Y.Z string +# even if this is a dirty or untagged Git working tree. +NUMERIC_VERSION = $(PACKAGE_VERSION) + +# If building from a Git repository, replace $(PACKAGE_VERSION) with the Git +# description of the working tree: either a release tag with the same value +# as $(PACKAGE_VERSION) above, or an exact description likely based on a tag. +# Much of this is also GNU Make-specific. If you don't have GNU Make and/or +# are not building from a Git repository, comment out this conditional. +ifneq "$(wildcard .git)" "" +original_version := $(PACKAGE_VERSION) +PACKAGE_VERSION := $(shell git describe --always --dirty) + +# Unless the Git description matches /\d*\.\d*(\.\d*)?/, i.e., is exactly a tag +# with a numeric name, revert $(NUMERIC_VERSION) to the original version number +# written above, but with the patchlevel field bumped to 255. +ifneq "$(subst ..,.,$(subst 0,,$(subst 1,,$(subst 2,,$(subst 3,,$(subst 4,,$(subst 5,,$(subst 6,,$(subst 7,,$(subst 8,,$(subst 9,,$(PACKAGE_VERSION))))))))))))" "." +empty := +NUMERIC_VERSION := $(subst $(empty) ,.,$(wordlist 1,2,$(subst ., ,$(original_version))) 255) +endif + +# Force version.h to be remade if $(PACKAGE_VERSION) has changed. +version.h: $(if $(wildcard version.h),$(if $(findstring "$(PACKAGE_VERSION)",$(shell cat version.h)),,force)) +endif + +version.h: + echo '#define HTS_VERSION "$(PACKAGE_VERSION)"' > $@ + +print-version: + @echo $(PACKAGE_VERSION) + + +.SUFFIXES: .c .o .pico + +.c.o: + $(CC) $(CFLAGS) $(CPPFLAGS) -c -o $@ $< + +.c.pico: + $(CC) $(CFLAGS) $(CPPFLAGS) $(EXTRA_CFLAGS_PIC) -c -o $@ $< + + +LIBHTS_OBJS = \ + kfunc.o \ + knetfile.o \ + kstring.o \ + bgzf.o \ + faidx.o \ + hfile.o \ + hfile_net.o \ + hts.o \ + regidx.o \ + sam.o \ + synced_bcf_reader.o \ + vcf_sweep.o \ + tbx.o \ + vcf.o \ + vcfutils.o \ + cram/cram_codecs.o \ + cram/cram_decode.o \ + cram/cram_encode.o \ + cram/cram_index.o \ + cram/cram_io.o \ + cram/cram_samtools.o \ + cram/cram_stats.o \ + cram/files.o \ + cram/mFILE.o \ + cram/md5.o \ + cram/open_trace_file.o \ + cram/pooled_alloc.o \ + cram/rANS_static.o \ + cram/sam_header.o \ + cram/string_alloc.o \ + cram/thread_pool.o \ + cram/vlen.o \ + cram/zfio.o + +cram_h = cram/cram.h $(cram_samtools_h) $(cram_sam_header_h) $(cram_structs_h) $(cram_io_h) cram/cram_encode.h cram/cram_decode.h cram/cram_stats.h cram/cram_codecs.h cram/cram_index.h +cram_io_h = cram/cram_io.h $(cram_misc_h) +cram_misc_h = cram/misc.h cram/os.h +cram_sam_header_h = cram/sam_header.h cram/string_alloc.h cram/pooled_alloc.h htslib/khash.h htslib/kstring.h +cram_samtools_h = cram/cram_samtools.h $(htslib_sam_h) $(cram_sam_header_h) +cram_structs_h = cram/cram_structs.h cram/thread_pool.h cram/string_alloc.h htslib/khash.h +cram_open_trace_file_h = cram/open_trace_file.h cram/mFILE.h +hfile_internal_h = hfile_internal.h $(htslib_hfile_h) + + +# To be effective, config.mk needs to appear after most Makefile variables are +# set but before most rules appear, so that it can both use previously-set +# variables in its own rules' prerequisites and also update variables for use +# in later rules' prerequisites. + +# sinclude is GNU Make-specific. If you don't have GNU Make or another make +# that understands sinclude, change this to 'include' if you are using the +# configure script or just comment the line out if you are not. +sinclude config.mk + + +libhts.a: $(LIBHTS_OBJS:.o=.pico) + @-rm -f $@ + $(AR) -rc $@ $(LIBHTS_OBJS:.o=.pico) + -$(RANLIB) $@ + + +# The target here is libhts.so, as that is the built file that other rules +# depend upon and that is used when -lhts appears in other program's recipes. +# As a byproduct invisible to make, libhts.so.NN is also created, as it is the +# file used at runtime (when $LD_LIBRARY_PATH includes the build directory). + +libhts.so: $(LIBHTS_OBJS:.o=.pico) + $(CC) -shared -Wl,-soname,libhts.so.$(LIBHTS_SOVERSION) -pthread $(LDFLAGS) -o $@ $(LIBHTS_OBJS:.o=.pico) $(LDLIBS) -lz -lm + ln -sf $@ libhts.so.$(LIBHTS_SOVERSION) + +# Similarly this also creates libhts.NN.dylib as a byproduct, so that programs +# when run can find this uninstalled shared library (when $DYLD_LIBRARY_PATH +# includes this project's build directory). + +libhts.dylib: $(LIBHTS_OBJS) + $(CC) -dynamiclib -install_name $(libdir)/libhts.$(LIBHTS_SOVERSION).dylib -current_version $(NUMERIC_VERSION) -compatibility_version $(LIBHTS_SOVERSION) $(LDFLAGS) -o $@ $(LIBHTS_OBJS) $(LDLIBS) -lz + ln -sf $@ libhts.$(LIBHTS_SOVERSION).dylib + + +bgzf.o bgzf.pico: bgzf.c $(htslib_hts_h) $(htslib_bgzf_h) $(htslib_hfile_h) htslib/khash.h +kstring.o kstring.pico: kstring.c htslib/kstring.h +knetfile.o knetfile.pico: knetfile.c htslib/knetfile.h +hfile.o hfile.pico: hfile.c $(htslib_hfile_h) $(hfile_internal_h) +hfile_irods.o hfile_irods.pico: hfile_irods.c $(hfile_internal_h) +hfile_net.o hfile_net.pico: hfile_net.c $(hfile_internal_h) htslib/knetfile.h +hts.o hts.pico: hts.c version.h $(htslib_hts_h) $(htslib_bgzf_h) $(cram_h) $(htslib_hfile_h) htslib/khash.h htslib/kseq.h htslib/ksort.h +vcf.o vcf.pico: vcf.c $(htslib_vcf_h) $(htslib_bgzf_h) $(htslib_tbx_h) $(htslib_hfile_h) htslib/khash.h htslib/kseq.h htslib/kstring.h +sam.o sam.pico: sam.c $(htslib_sam_h) $(htslib_bgzf_h) $(cram_h) $(htslib_hfile_h) htslib/khash.h htslib/kseq.h htslib/kstring.h +tbx.o tbx.pico: tbx.c $(htslib_tbx_h) $(htslib_bgzf_h) htslib/khash.h +faidx.o faidx.pico: faidx.c $(htslib_bgzf_h) $(htslib_faidx_h) $(htslib_hfile_h) htslib/khash.h +synced_bcf_reader.o synced_bcf_reader.pico: synced_bcf_reader.c $(htslib_synced_bcf_reader_h) htslib/kseq.h htslib/khash_str2int.h +vcf_sweep.o vcf_sweep.pico: vcf_sweep.c $(htslib_vcf_sweep_h) $(htslib_bgzf_h) +vcfutils.o vcfutils.pico: vcfutils.c $(htslib_vcfutils_h) +kfunc.o kfunc.pico: kfunc.c htslib/kfunc.h +regidx.o regidx.pico: regidx.c $(htslib_hts_h) $(HTSPREFIX)htslib/kstring.h $(HTSPREFIX)htslib/kseq.h $(HTSPREFIX)htslib/khash_str2int.h $(htslib_regidx_h) + +cram/cram_codecs.o cram/cram_codecs.pico: cram/cram_codecs.c $(cram_h) +cram/cram_decode.o cram/cram_decode.pico: cram/cram_decode.c $(cram_h) cram/os.h cram/md5.h +cram/cram_encode.o cram/cram_encode.pico: cram/cram_encode.c $(cram_h) cram/os.h cram/md5.h +cram/cram_index.o cram/cram_index.pico: cram/cram_index.c $(htslib_hfile_h) $(cram_h) cram/os.h cram/zfio.h +cram/cram_io.o cram/cram_io.pico: cram/cram_io.c $(cram_h) cram/os.h cram/md5.h $(cram_open_trace_file_h) cram/rANS_static.h $(htslib_hfile_h) +cram/cram_samtools.o cram/cram_samtools.pico: cram/cram_samtools.c $(cram_h) $(htslib_sam_h) +cram/cram_stats.o cram/cram_stats.pico: cram/cram_stats.c $(cram_h) cram/os.h +cram/files.o cram/files.pico: cram/files.c $(cram_misc_h) +cram/mFILE.o cram/mFILE.pico: cram/mFILE.c cram/os.h cram/mFILE.h cram/vlen.h +cram/md5.o cram/md5.pico: cram/md5.c cram/md5.h +cram/open_trace_file.o cram/open_trace_file.pico: cram/open_trace_file.c $(cram_open_trace_file_h) $(cram_misc_h) $(htslib_hfile_h) +cram/pooled_alloc.o cram/pooled_alloc.pico: cram/pooled_alloc.c cram/pooled_alloc.h +cram/rANS_static.o cram/rANS_static.pico: cram/rANS_static.c cram/rANS_static.h cram/rANS_byte.h +cram/sam_header.o cram/sam_header.pico: cram/sam_header.c $(cram_sam_header_h) cram/string_alloc.h +cram/string_alloc.o cram/string_alloc.pico: cram/string_alloc.c cram/string_alloc.h +cram/thread_pool.o cram/thread_pool.pico: cram/thread_pool.c cram/thread_pool.h +cram/vlen.o cram/vlen.pico: cram/vlen.c cram/vlen.h cram/os.h +cram/zfio.o cram/zfio.pico: cram/zfio.c cram/os.h cram/zfio.h + + +bgzip: bgzip.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ bgzip.o libhts.a $(LDLIBS) -lz + +htsfile: htsfile.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ htsfile.o libhts.a $(LDLIBS) -lz + +tabix: tabix.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ tabix.o libhts.a $(LDLIBS) -lz + +bgzip.o: bgzip.c $(htslib_bgzf_h) $(htslib_hts_h) +htsfile.o: htsfile.c $(htslib_hfile_h) $(htslib_hts_h) $(htslib_sam_h) $(htslib_vcf_h) +tabix.o: tabix.c $(htslib_tbx_h) $(htslib_sam_h) $(htslib_vcf_h) htslib/kseq.h $(htslib_bgzf_h) $(htslib_hts_h) + + +# For tests that might use it, set $REF_PATH explicitly to use only reference +# areas within the test suite (or set it to ':' to use no reference areas). +check test: $(BUILT_TEST_PROGRAMS) + test/fieldarith test/fieldarith.sam + test/hfile + test/sam test/ce.fa + test/test-regidx + cd test && REF_PATH=: ./test_view.pl + cd test && ./test.pl + +test/fieldarith: test/fieldarith.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ test/fieldarith.o libhts.a $(LDLIBS) -lz + +test/hfile: test/hfile.o libhts.a + $(CC) $(LDFLAGS) -o $@ test/hfile.o libhts.a $(LDLIBS) -lz + +test/sam: test/sam.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ test/sam.o libhts.a $(LDLIBS) -lz + +test/test-regidx: test/test-regidx.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ test/test-regidx.o libhts.a $(LDLIBS) -lz + +test/test_view: test/test_view.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ test/test_view.o libhts.a $(LDLIBS) -lz + +test/test-vcf-api: test/test-vcf-api.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ test/test-vcf-api.o libhts.a $(LDLIBS) -lz + +test/test-vcf-sweep: test/test-vcf-sweep.o libhts.a + $(CC) -pthread $(LDFLAGS) -o $@ test/test-vcf-sweep.o libhts.a $(LDLIBS) -lz + +test/fieldarith.o: test/fieldarith.c $(htslib_sam_h) +test/hfile.o: test/hfile.c $(htslib_hfile_h) $(htslib_hts_defs_h) +test/test-regidx.o: test/test-regidx.c $(htslib_regidx_h) +test/sam.o: test/sam.c $(htslib_sam_h) $(htslib_faidx_h) htslib/kstring.h +test/test_view.o: test/test_view.c $(cram_h) $(htslib_sam_h) +test/test-vcf-api.o: test/test-vcf-api.c $(htslib_hts_h) $(htslib_vcf_h) htslib/kstring.h +test/test-vcf-sweep.o: test/test-vcf-sweep.c $(htslib_vcf_sweep_h) + + +install: libhts.a $(BUILT_PROGRAMS) installdirs install-$(SHLIB_FLAVOUR) install-pkgconfig + $(INSTALL_PROGRAM) $(BUILT_PROGRAMS) $(DESTDIR)$(bindir) + $(INSTALL_DATA) htslib/*.h $(DESTDIR)$(includedir)/htslib + $(INSTALL_DATA) libhts.a $(DESTDIR)$(libdir)/libhts.a + $(INSTALL_DATA) htsfile.1 tabix.1 $(DESTDIR)$(man1dir) + $(INSTALL_DATA) faidx.5 sam.5 vcf.5 $(DESTDIR)$(man5dir) + +installdirs: + $(INSTALL_DIR) $(DESTDIR)$(bindir) $(DESTDIR)$(includedir) $(DESTDIR)$(includedir)/htslib $(DESTDIR)$(libdir) $(DESTDIR)$(man1dir) $(DESTDIR)$(man5dir) $(DESTDIR)$(pkgconfigdir) + +# After installation, the real file in $(libdir) will be libhts.so.X.Y.Z, +# with symlinks libhts.so (used via -lhts during linking of client programs) +# and libhts.so.NN (used by client executables at runtime). + +install-so: libhts.so installdirs + $(INSTALL_DATA) libhts.so $(DESTDIR)$(libdir)/libhts.so.$(PACKAGE_VERSION) + ln -sf libhts.so.$(PACKAGE_VERSION) $(DESTDIR)$(libdir)/libhts.so + ln -sf libhts.so.$(PACKAGE_VERSION) $(DESTDIR)$(libdir)/libhts.so.$(LIBHTS_SOVERSION) + +install-dylib: libhts.dylib installdirs + $(INSTALL_PROGRAM) libhts.dylib $(DESTDIR)$(libdir)/libhts.$(PACKAGE_VERSION).dylib + ln -sf libhts.$(PACKAGE_VERSION).dylib $(DESTDIR)$(libdir)/libhts.dylib + ln -sf libhts.$(PACKAGE_VERSION).dylib $(DESTDIR)$(libdir)/libhts.$(LIBHTS_SOVERSION).dylib + +# Substitute these pseudo-autoconf variables only at install time +# so that "make install prefix=/prefix/path" etc continue to work. +install-pkgconfig: installdirs + sed -e 's#@includedir@#$(includedir)#g;s#@libdir@#$(libdir)#g;s#@PACKAGE_VERSION@#$(PACKAGE_VERSION)#g' htslib.pc.in > $(DESTDIR)$(pkgconfigdir)/htslib.pc + chmod 644 $(DESTDIR)$(pkgconfigdir)/htslib.pc + +# A pkg-config file (suitable for copying to $PKG_CONFIG_PATH) that provides +# flags for building against the uninstalled library in this build directory. +htslib-uninstalled.pc: htslib.pc.in + sed -e 's#@includedir@#'`pwd`'#g;s#@libdir@#'`pwd`'#g' htslib.pc.in > $@ + + +testclean: + -rm -f test/*.tmp test/*.tmp.* + +mostlyclean: testclean + -rm -f *.o *.pico cram/*.o cram/*.pico test/*.o test/*.dSYM version.h + +clean: mostlyclean clean-$(SHLIB_FLAVOUR) + -rm -f libhts.a $(BUILT_PROGRAMS) $(BUILT_TEST_PROGRAMS) + +distclean: clean + -rm -f config.cache config.log config.mk config.status + -rm -f TAGS *-uninstalled.pc + +clean-so: + -rm -f libhts.so libhts.so.* + +clean-dylib: + -rm -f libhts.dylib libhts.*.dylib + + +tags: + ctags -f TAGS *.[ch] cram/*.[ch] htslib/*.h + + +force: + + +.PHONY: all check clean distclean force install install-pkgconfig installdirs +.PHONY: lib-shared lib-static mostlyclean print-version tags test testclean +.PHONY: clean-so install-so +.PHONY: clean-dylib install-dylib
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/NEWS Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,50 @@ +Noteworthy changes in release 1.2.1 (3 February 2015) + +* Reinstated hts_file_type() and FT_* macros, which were available until 1.1 + but briefly removed in 1.2. This function is deprecated and will be removed + in a future release -- you should use hts_detect_format() etc instead + + +Noteworthy changes in release 1.2 (2 February 2015) + +* HTSlib now has a configure script which checks your build environment + and allows for selection of optional extras. See INSTALL for details + +* By default, reference sequences are fetched from the EBI CRAM Reference + Registry and cached in your $HOME cache directory. This behaviour can + be controlled by setting REF_PATH and REF_CACHE enviroment variables + (see the samtools(1) man page for details) + +* Numerous CRAM improvements: + - Support for CRAM v3.0, an upcoming revision to CRAM supporting + better compression and per-container checksums + - EOF checking for v2.1 and v3.0 (similar to checking BAM EOF blocks) + - Non-standard values for PNEXT and TLEN fields are now preserved + - hts_set_fai_filename() now provides a reference file when encoding + - Generated read names are now numbered from 1, rather than being + labelled 'slice:record-in-slice' + - Multi-threading and speed improvements + +* New htsfile command for identifying file formats, and corresponding + file format detection APIs + +* New tabix --regions FILE, --targets FILE options for filtering via BED files + +* Optional iRODS file access, disabled by default. Configure with --with-irods + to enable accessing iRODS data objects directly via 'irods:DATAOBJ' + +* All occurences of 2^29 in the source have been eliminated, so indexing + and querying against reference sequences larger than 512Mbp works (when + using CSI indices) + +* Support for plain GZIP compression in various places + +* VCF header editing speed improvements + +* Added seq_nt16_int[] (equivalent to the samtools API's bam_nt16_nt4_table) + +* Reinstated faidx_fetch_nseq(), which was accidentally removed from 1.1. + Now faidx_fetch_nseq() and faidx_nseq() are equivalent; eventually + faidx_fetch_nseq() will be deprecated and removed [#156] + +* Fixed bugs #141, #152, #155, #158, #159, and various memory leaks
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/README Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +HTSlib is an implementation of a unified C library for accessing common file +formats, such as SAM, CRAM, VCF, and BCF, used for high-throughput sequencing +data. It is the core library used by samtools and bcftools. + +See INSTALL for building and installation instructions.
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/bgzf.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1124 @@ +/* The MIT License + + Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology + 2011, 2012 Attractive Chaos <attractor@live.co.uk> + Copyright (C) 2009, 2013, 2014 Genome Research Ltd + + Permission is hereby granted, free of charge, to any person obtaining a copy + of this software and associated documentation files (the "Software"), to deal + in the Software without restriction, including without limitation the rights + to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + copies of the Software, and to permit persons to whom the Software is + furnished to do so, subject to the following conditions: + + The above copyright notice and this permission notice shall be included in + all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + THE SOFTWARE. +*/ + +#include <stdio.h> +#include <stdlib.h> +#include <string.h> +#include <errno.h> +#include <unistd.h> +#include <assert.h> +#include <pthread.h> +#include <sys/types.h> +#include <inttypes.h> + +#include "htslib/hts.h" +#include "htslib/bgzf.h" +#include "htslib/hfile.h" + +#define BGZF_CACHE +#define BGZF_MT + +#define BLOCK_HEADER_LENGTH 18 +#define BLOCK_FOOTER_LENGTH 8 + + +/* BGZF/GZIP header (speciallized from RFC 1952; little endian): + +---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+ + | 31|139| 8| 4| 0| 0|255| 6| 66| 67| 2|BLK_LEN| + +---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+ + BGZF extension: + ^ ^ ^ ^ + | | | | + FLG.EXTRA XLEN B C + + BGZF format is compatible with GZIP. It limits the size of each compressed + block to 2^16 bytes and adds and an extra "BC" field in the gzip header which + records the size. + +*/ +static const uint8_t g_magic[19] = "\037\213\010\4\0\0\0\0\0\377\6\0\102\103\2\0\0\0"; + +#ifdef BGZF_CACHE +typedef struct { + int size; + uint8_t *block; + int64_t end_offset; +} cache_t; +#include "htslib/khash.h" +KHASH_MAP_INIT_INT64(cache, cache_t) +#endif + +typedef struct +{ + uint64_t uaddr; // offset w.r.t. uncompressed data + uint64_t caddr; // offset w.r.t. compressed data +} +bgzidx1_t; + +struct __bgzidx_t +{ + int noffs, moffs; // the size of the index, n:used, m:allocated + bgzidx1_t *offs; // offsets + uint64_t ublock_addr; // offset of the current block (uncompressed data) +}; + +void bgzf_index_destroy(BGZF *fp); +int bgzf_index_add_block(BGZF *fp); + +static inline void packInt16(uint8_t *buffer, uint16_t value) +{ + buffer[0] = value; + buffer[1] = value >> 8; +} + +static inline int unpackInt16(const uint8_t *buffer) +{ + return buffer[0] | buffer[1] << 8; +} + +static inline void packInt32(uint8_t *buffer, uint32_t value) +{ + buffer[0] = value; + buffer[1] = value >> 8; + buffer[2] = value >> 16; + buffer[3] = value >> 24; +} + +static BGZF *bgzf_read_init(hFILE *hfpr) +{ + BGZF *fp; + uint8_t magic[18]; + ssize_t n = hpeek(hfpr, magic, 18); + if (n < 0) return NULL; + + fp = (BGZF*)calloc(1, sizeof(BGZF)); + if (fp == NULL) return NULL; + + fp->is_write = 0; + fp->is_compressed = (n==2 && magic[0]==0x1f && magic[1]==0x8b); + fp->uncompressed_block = malloc(BGZF_MAX_BLOCK_SIZE); + fp->compressed_block = malloc(BGZF_MAX_BLOCK_SIZE); + fp->is_compressed = (n==18 && magic[0]==0x1f && magic[1]==0x8b) ? 1 : 0; + fp->is_gzip = ( !fp->is_compressed || ((magic[3]&4) && memcmp(&magic[12], "BC\2\0",4)==0) ) ? 0 : 1; +#ifdef BGZF_CACHE + fp->cache = kh_init(cache); +#endif + return fp; +} + +// get the compress level from the mode string: compress_level==-1 for the default level, -2 plain uncompressed +static int mode2level(const char *__restrict mode) +{ + int i, compress_level = -1; + for (i = 0; mode[i]; ++i) + if (mode[i] >= '0' && mode[i] <= '9') break; + if (mode[i]) compress_level = (int)mode[i] - '0'; + if (strchr(mode, 'u')) compress_level = -2; + return compress_level; +} +static BGZF *bgzf_write_init(const char *mode) +{ + BGZF *fp; + fp = (BGZF*)calloc(1, sizeof(BGZF)); + fp->is_write = 1; + int compress_level = mode2level(mode); + if ( compress_level==-2 ) + { + fp->is_compressed = 0; + return fp; + } + fp->is_compressed = 1; + fp->uncompressed_block = malloc(BGZF_MAX_BLOCK_SIZE); + fp->compressed_block = malloc(BGZF_MAX_BLOCK_SIZE); + fp->compress_level = compress_level < 0? Z_DEFAULT_COMPRESSION : compress_level; // Z_DEFAULT_COMPRESSION==-1 + if (fp->compress_level > 9) fp->compress_level = Z_DEFAULT_COMPRESSION; + if ( strchr(mode,'g') ) + { + // gzip output + fp->is_gzip = 1; + fp->gz_stream = (z_stream*)calloc(1,sizeof(z_stream)); + fp->gz_stream->zalloc = NULL; + fp->gz_stream->zfree = NULL; + if ( deflateInit2(fp->gz_stream, fp->compress_level, Z_DEFLATED, 15|16, 8, Z_DEFAULT_STRATEGY)!=Z_OK ) return NULL; + } + return fp; +} + +BGZF *bgzf_open(const char *path, const char *mode) +{ + BGZF *fp = 0; + assert(compressBound(BGZF_BLOCK_SIZE) < BGZF_MAX_BLOCK_SIZE); + if (strchr(mode, 'r')) { + hFILE *fpr; + if ((fpr = hopen(path, mode)) == 0) return 0; + fp = bgzf_read_init(fpr); + if (fp == 0) { hclose_abruptly(fpr); return NULL; } + fp->fp = fpr; + } else if (strchr(mode, 'w') || strchr(mode, 'a')) { + hFILE *fpw; + if ((fpw = hopen(path, mode)) == 0) return 0; + fp = bgzf_write_init(mode); + fp->fp = fpw; + } + else { errno = EINVAL; return 0; } + + fp->is_be = ed_is_big(); + return fp; +} + +BGZF *bgzf_dopen(int fd, const char *mode) +{ + BGZF *fp = 0; + assert(compressBound(BGZF_BLOCK_SIZE) < BGZF_MAX_BLOCK_SIZE); + if (strchr(mode, 'r')) { + hFILE *fpr; + if ((fpr = hdopen(fd, mode)) == 0) return 0; + fp = bgzf_read_init(fpr); + if (fp == 0) { hclose_abruptly(fpr); return NULL; } // FIXME this closes fd + fp->fp = fpr; + } else if (strchr(mode, 'w') || strchr(mode, 'a')) { + hFILE *fpw; + if ((fpw = hdopen(fd, mode)) == 0) return 0; + fp = bgzf_write_init(mode); + fp->fp = fpw; + } + else { errno = EINVAL; return 0; } + + fp->is_be = ed_is_big(); + return fp; +} + +BGZF *bgzf_hopen(hFILE *hfp, const char *mode) +{ + BGZF *fp = NULL; + assert(compressBound(BGZF_BLOCK_SIZE) < BGZF_MAX_BLOCK_SIZE); + if (strchr(mode, 'r')) { + fp = bgzf_read_init(hfp); + if (fp == NULL) return NULL; + } else if (strchr(mode, 'w') || strchr(mode, 'a')) { + fp = bgzf_write_init(mode); + } + else { errno = EINVAL; return 0; } + + fp->fp = hfp; + fp->is_be = ed_is_big(); + return fp; +} + +static int bgzf_compress(void *_dst, int *dlen, void *src, int slen, int level) +{ + uint32_t crc; + z_stream zs; + uint8_t *dst = (uint8_t*)_dst; + + // compress the body + zs.zalloc = NULL; zs.zfree = NULL; + zs.next_in = (Bytef*)src; + zs.avail_in = slen; + zs.next_out = dst + BLOCK_HEADER_LENGTH; + zs.avail_out = *dlen - BLOCK_HEADER_LENGTH - BLOCK_FOOTER_LENGTH; + if (deflateInit2(&zs, level, Z_DEFLATED, -15, 8, Z_DEFAULT_STRATEGY) != Z_OK) return -1; // -15 to disable zlib header/footer + if (deflate(&zs, Z_FINISH) != Z_STREAM_END) return -1; + if (deflateEnd(&zs) != Z_OK) return -1; + *dlen = zs.total_out + BLOCK_HEADER_LENGTH + BLOCK_FOOTER_LENGTH; + // write the header + memcpy(dst, g_magic, BLOCK_HEADER_LENGTH); // the last two bytes are a place holder for the length of the block + packInt16(&dst[16], *dlen - 1); // write the compressed length; -1 to fit 2 bytes + // write the footer + crc = crc32(crc32(0L, NULL, 0L), (Bytef*)src, slen); + packInt32((uint8_t*)&dst[*dlen - 8], crc); + packInt32((uint8_t*)&dst[*dlen - 4], slen); + return 0; +} + +static int bgzf_gzip_compress(BGZF *fp, void *_dst, int *dlen, void *src, int slen, int level) +{ + uint8_t *dst = (uint8_t*)_dst; + z_stream *zs = fp->gz_stream; + int flush = slen ? Z_NO_FLUSH : Z_FINISH; + zs->next_in = (Bytef*)src; + zs->avail_in = slen; + zs->next_out = dst; + zs->avail_out = *dlen; + if ( deflate(zs, flush) == Z_STREAM_ERROR ) return -1; + *dlen = *dlen - zs->avail_out; + return 0; +} + +// Deflate the block in fp->uncompressed_block into fp->compressed_block. Also adds an extra field that stores the compressed block length. +static int deflate_block(BGZF *fp, int block_length) +{ + int comp_size = BGZF_MAX_BLOCK_SIZE; + int ret; + if ( !fp->is_gzip ) + ret = bgzf_compress(fp->compressed_block, &comp_size, fp->uncompressed_block, block_length, fp->compress_level); + else + ret = bgzf_gzip_compress(fp, fp->compressed_block, &comp_size, fp->uncompressed_block, block_length, fp->compress_level); + + if ( ret != 0 ) + { + fp->errcode |= BGZF_ERR_ZLIB; + return -1; + } + fp->block_offset = 0; + return comp_size; +} + +// Inflate the block in fp->compressed_block into fp->uncompressed_block +static int inflate_block(BGZF* fp, int block_length) +{ + z_stream zs; + zs.zalloc = NULL; + zs.zfree = NULL; + zs.next_in = (Bytef*)fp->compressed_block + 18; + zs.avail_in = block_length - 16; + zs.next_out = (Bytef*)fp->uncompressed_block; + zs.avail_out = BGZF_MAX_BLOCK_SIZE; + + if (inflateInit2(&zs, -15) != Z_OK) { + fp->errcode |= BGZF_ERR_ZLIB; + return -1; + } + if (inflate(&zs, Z_FINISH) != Z_STREAM_END) { + inflateEnd(&zs); + fp->errcode |= BGZF_ERR_ZLIB; + return -1; + } + if (inflateEnd(&zs) != Z_OK) { + fp->errcode |= BGZF_ERR_ZLIB; + return -1; + } + return zs.total_out; +} + +static int inflate_gzip_block(BGZF *fp, int cached) +{ + int ret = Z_OK; + do + { + if ( !cached && fp->gz_stream->avail_out!=0 ) + { + fp->gz_stream->avail_in = hread(fp->fp, fp->compressed_block, BGZF_BLOCK_SIZE); + if ( fp->gz_stream->avail_in<=0 ) return fp->gz_stream->avail_in; + if ( fp->gz_stream->avail_in==0 ) break; + fp->gz_stream->next_in = fp->compressed_block; + } + else cached = 0; + do + { + fp->gz_stream->next_out = (Bytef*)fp->uncompressed_block + fp->block_offset; + fp->gz_stream->avail_out = BGZF_MAX_BLOCK_SIZE - fp->block_offset; + ret = inflate(fp->gz_stream, Z_NO_FLUSH); + if ( ret==Z_BUF_ERROR ) continue; // non-critical error + if ( ret<0 ) return -1; + unsigned int have = BGZF_MAX_BLOCK_SIZE - fp->gz_stream->avail_out; + if ( have ) return have; + } + while ( fp->gz_stream->avail_out == 0 ); + } + while (ret != Z_STREAM_END); + return BGZF_MAX_BLOCK_SIZE - fp->gz_stream->avail_out; +} + +// Returns: 0 on success (BGZF header); -1 on non-BGZF GZIP header; -2 on error +static int check_header(const uint8_t *header) +{ + if ( header[0] != 31 || header[1] != 139 || header[2] != 8 ) return -2; + return ((header[3] & 4) != 0 + && unpackInt16((uint8_t*)&header[10]) == 6 + && header[12] == 'B' && header[13] == 'C' + && unpackInt16((uint8_t*)&header[14]) == 2) ? 0 : -1; +} + +#ifdef BGZF_CACHE +static void free_cache(BGZF *fp) +{ + khint_t k; + khash_t(cache) *h = (khash_t(cache)*)fp->cache; + if (fp->is_write) return; + for (k = kh_begin(h); k < kh_end(h); ++k) + if (kh_exist(h, k)) free(kh_val(h, k).block); + kh_destroy(cache, h); +} + +static int load_block_from_cache(BGZF *fp, int64_t block_address) +{ + khint_t k; + cache_t *p; + khash_t(cache) *h = (khash_t(cache)*)fp->cache; + k = kh_get(cache, h, block_address); + if (k == kh_end(h)) return 0; + p = &kh_val(h, k); + if (fp->block_length != 0) fp->block_offset = 0; + fp->block_address = block_address; + fp->block_length = p->size; + memcpy(fp->uncompressed_block, p->block, BGZF_MAX_BLOCK_SIZE); + if ( hseek(fp->fp, p->end_offset, SEEK_SET) < 0 ) + { + // todo: move the error up + fprintf(stderr,"Could not hseek to %"PRId64"\n", p->end_offset); + exit(1); + } + return p->size; +} + +static void cache_block(BGZF *fp, int size) +{ + int ret; + khint_t k; + cache_t *p; + khash_t(cache) *h = (khash_t(cache)*)fp->cache; + if (BGZF_MAX_BLOCK_SIZE >= fp->cache_size) return; + if ((kh_size(h) + 1) * BGZF_MAX_BLOCK_SIZE > (uint32_t)fp->cache_size) { + /* A better way would be to remove the oldest block in the + * cache, but here we remove a random one for simplicity. This + * should not have a big impact on performance. */ + for (k = kh_begin(h); k < kh_end(h); ++k) + if (kh_exist(h, k)) break; + if (k < kh_end(h)) { + free(kh_val(h, k).block); + kh_del(cache, h, k); + } + } + k = kh_put(cache, h, fp->block_address, &ret); + if (ret == 0) return; // if this happens, a bug! + p = &kh_val(h, k); + p->size = fp->block_length; + p->end_offset = fp->block_address + size; + p->block = (uint8_t*)malloc(BGZF_MAX_BLOCK_SIZE); + memcpy(kh_val(h, k).block, fp->uncompressed_block, BGZF_MAX_BLOCK_SIZE); +} +#else +static void free_cache(BGZF *fp) {} +static int load_block_from_cache(BGZF *fp, int64_t block_address) {return 0;} +static void cache_block(BGZF *fp, int size) {} +#endif + +int bgzf_read_block(BGZF *fp) +{ + uint8_t header[BLOCK_HEADER_LENGTH], *compressed_block; + int count, size = 0, block_length, remaining; + + // Reading an uncompressed file + if ( !fp->is_compressed ) + { + count = hread(fp->fp, fp->uncompressed_block, BGZF_MAX_BLOCK_SIZE); + if ( count==0 ) + { + fp->block_length = 0; + return 0; + } + if (fp->block_length != 0) fp->block_offset = 0; + fp->block_address += count; + fp->block_length = count; + return 0; + } + + // Reading compressed file + int64_t block_address; + block_address = htell(fp->fp); + if ( fp->is_gzip && fp->gz_stream ) // is this is a initialized gzip stream? + { + count = inflate_gzip_block(fp, 0); + if ( count<0 ) + { + fp->errcode |= BGZF_ERR_ZLIB; + return -1; + } + fp->block_length = count; + fp->block_address = block_address; + return 0; + } + if (fp->cache_size && load_block_from_cache(fp, block_address)) return 0; + count = hread(fp->fp, header, sizeof(header)); + if (count == 0) { // no data read + fp->block_length = 0; + return 0; + } + int ret; + if ( count != sizeof(header) || (ret=check_header(header))==-2 ) + { + fp->errcode |= BGZF_ERR_HEADER; + return -1; + } + if ( ret==-1 ) + { + // GZIP, not BGZF + uint8_t *cblock = (uint8_t*)fp->compressed_block; + memcpy(cblock, header, sizeof(header)); + count = hread(fp->fp, cblock+sizeof(header), BGZF_BLOCK_SIZE - sizeof(header)) + sizeof(header); + int nskip = 10; + + // Check optional fields to skip: FLG.FNAME,FLG.FCOMMENT,FLG.FHCRC,FLG.FEXTRA + // Note: Some of these fields are untested, I did not have appropriate data available + if ( header[3] & 0x4 ) // FLG.FEXTRA + { + nskip += unpackInt16(&cblock[nskip]) + 2; + } + if ( header[3] & 0x8 ) // FLG.FNAME + { + while ( nskip<BGZF_BLOCK_SIZE && cblock[nskip] ) nskip++; + if ( nskip==BGZF_BLOCK_SIZE ) + { + fp->errcode |= BGZF_ERR_HEADER; + return -1; + } + nskip++; + } + if ( header[3] & 0x10 ) // FLG.FCOMMENT + { + while ( nskip<BGZF_BLOCK_SIZE && cblock[nskip] ) nskip++; + if ( nskip==BGZF_BLOCK_SIZE ) + { + fp->errcode |= BGZF_ERR_HEADER; + return -1; + } + nskip++; + } + if ( header[3] & 0x2 ) nskip += 2; // FLG.FHCRC + + fp->is_gzip = 1; + fp->gz_stream = (z_stream*) calloc(1,sizeof(z_stream)); + int ret = inflateInit2(fp->gz_stream, -15); + if (ret != Z_OK) + { + fp->errcode |= BGZF_ERR_ZLIB; + return -1; + } + fp->gz_stream->avail_in = count - nskip; + fp->gz_stream->next_in = cblock + nskip; + count = inflate_gzip_block(fp, 1); + if ( count<0 ) + { + fp->errcode |= BGZF_ERR_ZLIB; + return -1; + } + fp->block_length = count; + fp->block_address = block_address; + if ( fp->idx_build_otf ) return -1; // cannot build index for gzip + return 0; + } + size = count; + block_length = unpackInt16((uint8_t*)&header[16]) + 1; // +1 because when writing this number, we used "-1" + compressed_block = (uint8_t*)fp->compressed_block; + memcpy(compressed_block, header, BLOCK_HEADER_LENGTH); + remaining = block_length - BLOCK_HEADER_LENGTH; + count = hread(fp->fp, &compressed_block[BLOCK_HEADER_LENGTH], remaining); + if (count != remaining) { + fp->errcode |= BGZF_ERR_IO; + return -1; + } + size += count; + if ((count = inflate_block(fp, block_length)) < 0) return -1; + if (fp->block_length != 0) fp->block_offset = 0; // Do not reset offset if this read follows a seek. + fp->block_address = block_address; + fp->block_length = count; + if ( fp->idx_build_otf ) + { + bgzf_index_add_block(fp); + fp->idx->ublock_addr += count; + } + cache_block(fp, size); + return 0; +} + +ssize_t bgzf_read(BGZF *fp, void *data, size_t length) +{ + ssize_t bytes_read = 0; + uint8_t *output = (uint8_t*)data; + if (length <= 0) return 0; + assert(fp->is_write == 0); + while (bytes_read < length) { + int copy_length, available = fp->block_length - fp->block_offset; + uint8_t *buffer; + if (available <= 0) { + if (bgzf_read_block(fp) != 0) return -1; + available = fp->block_length - fp->block_offset; + if (available <= 0) break; + } + copy_length = length - bytes_read < available? length - bytes_read : available; + buffer = (uint8_t*)fp->uncompressed_block; + memcpy(output, buffer + fp->block_offset, copy_length); + fp->block_offset += copy_length; + output += copy_length; + bytes_read += copy_length; + } + if (fp->block_offset == fp->block_length) { + fp->block_address = htell(fp->fp); + fp->block_offset = fp->block_length = 0; + } + fp->uncompressed_address += bytes_read; + return bytes_read; +} + +ssize_t bgzf_raw_read(BGZF *fp, void *data, size_t length) +{ + return hread(fp->fp, data, length); +} + +#ifdef BGZF_MT + +typedef struct { + struct bgzf_mtaux_t *mt; + void *buf; + int i, errcode, toproc, compress_level; +} worker_t; + +typedef struct bgzf_mtaux_t { + int n_threads, n_blks, curr, done; + volatile int proc_cnt; + void **blk; + int *len; + worker_t *w; + pthread_t *tid; + pthread_mutex_t lock; + pthread_cond_t cv; +} mtaux_t; + +static int worker_aux(worker_t *w) +{ + int i, stop = 0; + // wait for condition: to process or all done + pthread_mutex_lock(&w->mt->lock); + while (!w->toproc && !w->mt->done) + pthread_cond_wait(&w->mt->cv, &w->mt->lock); + if (w->mt->done) stop = 1; + w->toproc = 0; + pthread_mutex_unlock(&w->mt->lock); + if (stop) return 1; // to quit the thread + w->errcode = 0; + for (i = w->i; i < w->mt->curr; i += w->mt->n_threads) { + int clen = BGZF_MAX_BLOCK_SIZE; + if (bgzf_compress(w->buf, &clen, w->mt->blk[i], w->mt->len[i], w->compress_level) != 0) + w->errcode |= BGZF_ERR_ZLIB; + memcpy(w->mt->blk[i], w->buf, clen); + w->mt->len[i] = clen; + } + __sync_fetch_and_add(&w->mt->proc_cnt, 1); + return 0; +} + +static void *mt_worker(void *data) +{ + while (worker_aux((worker_t*)data) == 0); + return 0; +} + +int bgzf_mt(BGZF *fp, int n_threads, int n_sub_blks) +{ + int i; + mtaux_t *mt; + pthread_attr_t attr; + if (!fp->is_write || fp->mt || n_threads <= 1) return -1; + mt = (mtaux_t*)calloc(1, sizeof(mtaux_t)); + mt->n_threads = n_threads; + mt->n_blks = n_threads * n_sub_blks; + mt->len = (int*)calloc(mt->n_blks, sizeof(int)); + mt->blk = (void**)calloc(mt->n_blks, sizeof(void*)); + for (i = 0; i < mt->n_blks; ++i) + mt->blk[i] = malloc(BGZF_MAX_BLOCK_SIZE); + mt->tid = (pthread_t*)calloc(mt->n_threads, sizeof(pthread_t)); // tid[0] is not used, as the worker 0 is launched by the master + mt->w = (worker_t*)calloc(mt->n_threads, sizeof(worker_t)); + for (i = 0; i < mt->n_threads; ++i) { + mt->w[i].i = i; + mt->w[i].mt = mt; + mt->w[i].compress_level = fp->compress_level; + mt->w[i].buf = malloc(BGZF_MAX_BLOCK_SIZE); + } + pthread_attr_init(&attr); + pthread_attr_setdetachstate(&attr, PTHREAD_CREATE_JOINABLE); + pthread_mutex_init(&mt->lock, 0); + pthread_cond_init(&mt->cv, 0); + for (i = 1; i < mt->n_threads; ++i) // worker 0 is effectively launched by the master thread + pthread_create(&mt->tid[i], &attr, mt_worker, &mt->w[i]); + fp->mt = mt; + return 0; +} + +static void mt_destroy(mtaux_t *mt) +{ + int i; + // signal all workers to quit + pthread_mutex_lock(&mt->lock); + mt->done = 1; mt->proc_cnt = 0; + pthread_cond_broadcast(&mt->cv); + pthread_mutex_unlock(&mt->lock); + for (i = 1; i < mt->n_threads; ++i) pthread_join(mt->tid[i], 0); // worker 0 is effectively launched by the master thread + // free other data allocated on heap + for (i = 0; i < mt->n_blks; ++i) free(mt->blk[i]); + for (i = 0; i < mt->n_threads; ++i) free(mt->w[i].buf); + free(mt->blk); free(mt->len); free(mt->w); free(mt->tid); + pthread_cond_destroy(&mt->cv); + pthread_mutex_destroy(&mt->lock); + free(mt); +} + +static void mt_queue(BGZF *fp) +{ + mtaux_t *mt = fp->mt; + assert(mt->curr < mt->n_blks); // guaranteed by the caller + memcpy(mt->blk[mt->curr], fp->uncompressed_block, fp->block_offset); + mt->len[mt->curr] = fp->block_offset; + fp->block_offset = 0; + ++mt->curr; +} + +static int mt_flush_queue(BGZF *fp) +{ + int i; + mtaux_t *mt = fp->mt; + // signal all the workers to compress + pthread_mutex_lock(&mt->lock); + for (i = 0; i < mt->n_threads; ++i) mt->w[i].toproc = 1; + mt->proc_cnt = 0; + pthread_cond_broadcast(&mt->cv); + pthread_mutex_unlock(&mt->lock); + // worker 0 is doing things here + worker_aux(&mt->w[0]); + // wait for all the threads to complete + while (mt->proc_cnt < mt->n_threads); + // dump data to disk + for (i = 0; i < mt->n_threads; ++i) fp->errcode |= mt->w[i].errcode; + for (i = 0; i < mt->curr; ++i) + if (hwrite(fp->fp, mt->blk[i], mt->len[i]) != mt->len[i]) { + fp->errcode |= BGZF_ERR_IO; + break; + } + mt->curr = 0; + return (fp->errcode == 0)? 0 : -1; +} + +static int lazy_flush(BGZF *fp) +{ + if (fp->mt) { + if (fp->block_offset) mt_queue(fp); + return (fp->mt->curr < fp->mt->n_blks)? 0 : mt_flush_queue(fp); + } + else return bgzf_flush(fp); +} + +#else // ~ #ifdef BGZF_MT + +int bgzf_mt(BGZF *fp, int n_threads, int n_sub_blks) +{ + return 0; +} + +static inline int lazy_flush(BGZF *fp) +{ + return bgzf_flush(fp); +} + +#endif // ~ #ifdef BGZF_MT + +int bgzf_flush(BGZF *fp) +{ + if (!fp->is_write) return 0; +#ifdef BGZF_MT + if (fp->mt) { + if (fp->block_offset) mt_queue(fp); // guaranteed that assertion does not fail + return mt_flush_queue(fp); + } +#endif + while (fp->block_offset > 0) { + if ( fp->idx_build_otf ) + { + bgzf_index_add_block(fp); + fp->idx->ublock_addr += fp->block_offset; + } + int block_length = deflate_block(fp, fp->block_offset); + if (block_length < 0) return -1; + if (hwrite(fp->fp, fp->compressed_block, block_length) != block_length) { + fp->errcode |= BGZF_ERR_IO; // possibly truncated file + return -1; + } + fp->block_address += block_length; + } + return 0; +} + +int bgzf_flush_try(BGZF *fp, ssize_t size) +{ + if (fp->block_offset + size > BGZF_BLOCK_SIZE) return lazy_flush(fp); + return 0; +} + +ssize_t bgzf_write(BGZF *fp, const void *data, size_t length) +{ + if ( !fp->is_compressed ) + return hwrite(fp->fp, data, length); + + const uint8_t *input = (const uint8_t*)data; + ssize_t remaining = length; + assert(fp->is_write); + while (remaining > 0) { + uint8_t* buffer = (uint8_t*)fp->uncompressed_block; + int copy_length = BGZF_BLOCK_SIZE - fp->block_offset; + if (copy_length > remaining) copy_length = remaining; + memcpy(buffer + fp->block_offset, input, copy_length); + fp->block_offset += copy_length; + input += copy_length; + remaining -= copy_length; + if (fp->block_offset == BGZF_BLOCK_SIZE) { + if (lazy_flush(fp) != 0) return -1; + } + } + return length - remaining; +} + +ssize_t bgzf_raw_write(BGZF *fp, const void *data, size_t length) +{ + return hwrite(fp->fp, data, length); +} + +int bgzf_close(BGZF* fp) +{ + int ret, block_length; + if (fp == 0) return -1; + if (fp->is_write && fp->is_compressed) { + if (bgzf_flush(fp) != 0) return -1; + fp->compress_level = -1; + block_length = deflate_block(fp, 0); // write an empty block + if (hwrite(fp->fp, fp->compressed_block, block_length) < 0 + || hflush(fp->fp) != 0) { + fp->errcode |= BGZF_ERR_IO; + return -1; + } +#ifdef BGZF_MT + if (fp->mt) mt_destroy(fp->mt); +#endif + } + if ( fp->is_gzip ) + { + if (!fp->is_write) (void)inflateEnd(fp->gz_stream); + else (void)deflateEnd(fp->gz_stream); + free(fp->gz_stream); + } + ret = hclose(fp->fp); + if (ret != 0) return -1; + bgzf_index_destroy(fp); + free(fp->uncompressed_block); + free(fp->compressed_block); + free_cache(fp); + free(fp); + return 0; +} + +void bgzf_set_cache_size(BGZF *fp, int cache_size) +{ + if (fp) fp->cache_size = cache_size; +} + +int bgzf_check_EOF(BGZF *fp) +{ + uint8_t buf[28]; + off_t offset = htell(fp->fp); + if (hseek(fp->fp, -28, SEEK_END) < 0) { + if (errno == ESPIPE) { hclearerr(fp->fp); return 2; } + else return -1; + } + if ( hread(fp->fp, buf, 28) != 28 ) return -1; + if ( hseek(fp->fp, offset, SEEK_SET) < 0 ) return -1; + return (memcmp("\037\213\010\4\0\0\0\0\0\377\6\0\102\103\2\0\033\0\3\0\0\0\0\0\0\0\0\0", buf, 28) == 0)? 1 : 0; +} + +int64_t bgzf_seek(BGZF* fp, int64_t pos, int where) +{ + int block_offset; + int64_t block_address; + + if (fp->is_write || where != SEEK_SET) { + fp->errcode |= BGZF_ERR_MISUSE; + return -1; + } + block_offset = pos & 0xFFFF; + block_address = pos >> 16; + if (hseek(fp->fp, block_address, SEEK_SET) < 0) { + fp->errcode |= BGZF_ERR_IO; + return -1; + } + fp->block_length = 0; // indicates current block has not been loaded + fp->block_address = block_address; + fp->block_offset = block_offset; + return 0; +} + +int bgzf_is_bgzf(const char *fn) +{ + uint8_t buf[16]; + int n; + hFILE *fp; + if ((fp = hopen(fn, "r")) == 0) return 0; + n = hread(fp, buf, 16); + if ( hclose(fp) < 0 ) return -1; + if (n != 16) return 0; + return memcmp(g_magic, buf, 16) == 0? 1 : 0; +} + +int bgzf_getc(BGZF *fp) +{ + int c; + if (fp->block_offset >= fp->block_length) { + if (bgzf_read_block(fp) != 0) return -2; /* error */ + if (fp->block_length == 0) return -1; /* end-of-file */ + } + c = ((unsigned char*)fp->uncompressed_block)[fp->block_offset++]; + if (fp->block_offset == fp->block_length) { + fp->block_address = htell(fp->fp); + fp->block_offset = 0; + fp->block_length = 0; + } + fp->uncompressed_address++; + return c; +} + +#ifndef kroundup32 +#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x)) +#endif + +int bgzf_getline(BGZF *fp, int delim, kstring_t *str) +{ + int l, state = 0; + unsigned char *buf = (unsigned char*)fp->uncompressed_block; + str->l = 0; + do { + if (fp->block_offset >= fp->block_length) { + if (bgzf_read_block(fp) != 0) { state = -2; break; } + if (fp->block_length == 0) { state = -1; break; } + } + for (l = fp->block_offset; l < fp->block_length && buf[l] != delim; ++l); + if (l < fp->block_length) state = 1; + l -= fp->block_offset; + if (str->l + l + 1 >= str->m) { + str->m = str->l + l + 2; + kroundup32(str->m); + str->s = (char*)realloc(str->s, str->m); + } + memcpy(str->s + str->l, buf + fp->block_offset, l); + str->l += l; + fp->block_offset += l + 1; + if (fp->block_offset >= fp->block_length) { + fp->block_address = htell(fp->fp); + fp->block_offset = 0; + fp->block_length = 0; + } + } while (state == 0); + if (str->l == 0 && state < 0) return state; + fp->uncompressed_address += str->l; + if ( delim=='\n' && str->l>0 && str->s[str->l-1]=='\r' ) str->l--; + str->s[str->l] = 0; + return str->l; +} + +void bgzf_index_destroy(BGZF *fp) +{ + if ( !fp->idx ) return; + free(fp->idx->offs); + free(fp->idx); + fp->idx = NULL; + fp->idx_build_otf = 0; +} + +int bgzf_index_build_init(BGZF *fp) +{ + bgzf_index_destroy(fp); + fp->idx = (bgzidx_t*) calloc(1,sizeof(bgzidx_t)); + if ( !fp->idx ) return -1; + fp->idx_build_otf = 1; // build index on the fly + return 0; +} + +int bgzf_index_add_block(BGZF *fp) +{ + fp->idx->noffs++; + if ( fp->idx->noffs > fp->idx->moffs ) + { + fp->idx->moffs = fp->idx->noffs; + kroundup32(fp->idx->moffs); + fp->idx->offs = (bgzidx1_t*) realloc(fp->idx->offs, fp->idx->moffs*sizeof(bgzidx1_t)); + if ( !fp->idx->offs ) return -1; + } + fp->idx->offs[ fp->idx->noffs-1 ].uaddr = fp->idx->ublock_addr; + fp->idx->offs[ fp->idx->noffs-1 ].caddr = fp->block_address; + return 0; +} + +int bgzf_index_dump(BGZF *fp, const char *bname, const char *suffix) +{ + if (bgzf_flush(fp) != 0) return -1; + + assert(fp->idx); + char *tmp = NULL; + if ( suffix ) + { + int blen = strlen(bname); + int slen = strlen(suffix); + tmp = (char*) malloc(blen + slen + 1); + if ( !tmp ) return -1; + memcpy(tmp,bname,blen); + memcpy(tmp+blen,suffix,slen+1); + } + + FILE *idx = fopen(tmp?tmp:bname,"wb"); + if ( tmp ) free(tmp); + if ( !idx ) return -1; + + // Note that the index contains one extra record when indexing files opened + // for reading. The terminating record is not present when opened for writing. + // This is not a bug. + + int i; + if ( fp->is_be ) + { + uint64_t x = fp->idx->noffs - 1; + fwrite(ed_swap_8p(&x), 1, sizeof(x), idx); + for (i=1; i<fp->idx->noffs; i++) + { + x = fp->idx->offs[i].caddr; fwrite(ed_swap_8p(&x), 1, sizeof(x), idx); + x = fp->idx->offs[i].uaddr; fwrite(ed_swap_8p(&x), 1, sizeof(x), idx); + } + } + else + { + uint64_t x = fp->idx->noffs - 1; + fwrite(&x, 1, sizeof(x), idx); + for (i=1; i<fp->idx->noffs; i++) + { + fwrite(&fp->idx->offs[i].caddr, 1, sizeof(fp->idx->offs[i].caddr), idx); + fwrite(&fp->idx->offs[i].uaddr, 1, sizeof(fp->idx->offs[i].uaddr), idx); + } + } + fclose(idx); + return 0; +} + + +int bgzf_index_load(BGZF *fp, const char *bname, const char *suffix) +{ + char *tmp = NULL; + if ( suffix ) + { + int blen = strlen(bname); + int slen = strlen(suffix); + tmp = (char*) malloc(blen + slen + 1); + if ( !tmp ) return -1; + memcpy(tmp,bname,blen); + memcpy(tmp+blen,suffix,slen+1); + } + + FILE *idx = fopen(tmp?tmp:bname,"rb"); + if ( tmp ) free(tmp); + if ( !idx ) return -1; + + fp->idx = (bgzidx_t*) calloc(1,sizeof(bgzidx_t)); + uint64_t x; + if ( fread(&x, 1, sizeof(x), idx) != sizeof(x) ) return -1; + + fp->idx->noffs = fp->idx->moffs = 1 + (fp->is_be ? ed_swap_8(x) : x); + fp->idx->offs = (bgzidx1_t*) malloc(fp->idx->moffs*sizeof(bgzidx1_t)); + fp->idx->offs[0].caddr = fp->idx->offs[0].uaddr = 0; + + int i; + if ( fp->is_be ) + { + int ret = 0; + for (i=1; i<fp->idx->noffs; i++) + { + ret += fread(&x, 1, sizeof(x), idx); fp->idx->offs[i].caddr = ed_swap_8(x); + ret += fread(&x, 1, sizeof(x), idx); fp->idx->offs[i].uaddr = ed_swap_8(x); + } + if ( ret != sizeof(x)*2*(fp->idx->noffs-1) ) return -1; + } + else + { + int ret = 0; + for (i=1; i<fp->idx->noffs; i++) + { + ret += fread(&x, 1, sizeof(x), idx); fp->idx->offs[i].caddr = x; + ret += fread(&x, 1, sizeof(x), idx); fp->idx->offs[i].uaddr = x; + } + if ( ret != sizeof(x)*2*(fp->idx->noffs-1) ) return -1; + } + fclose(idx); + return 0; + +} + +int bgzf_useek(BGZF *fp, long uoffset, int where) +{ + if ( !fp->is_compressed ) + { + if (hseek(fp->fp, uoffset, SEEK_SET) < 0) + { + fp->errcode |= BGZF_ERR_IO; + return -1; + } + fp->block_length = 0; // indicates current block has not been loaded + fp->block_address = uoffset; + fp->block_offset = 0; + bgzf_read_block(fp); + fp->uncompressed_address = uoffset; + return 0; + } + + if ( !fp->idx ) + { + fp->errcode |= BGZF_ERR_IO; + return -1; + } + + // binary search + int ilo = 0, ihi = fp->idx->noffs - 1; + while ( ilo<=ihi ) + { + int i = (ilo+ihi)*0.5; + if ( uoffset < fp->idx->offs[i].uaddr ) ihi = i - 1; + else if ( uoffset >= fp->idx->offs[i].uaddr ) ilo = i + 1; + else break; + } + int i = ilo-1; + if (hseek(fp->fp, fp->idx->offs[i].caddr, SEEK_SET) < 0) + { + fp->errcode |= BGZF_ERR_IO; + return -1; + } + fp->block_length = 0; // indicates current block has not been loaded + fp->block_address = fp->idx->offs[i].caddr; + fp->block_offset = 0; + if ( bgzf_read_block(fp) < 0 ) return -1; + if ( uoffset - fp->idx->offs[i].uaddr > 0 ) + { + fp->block_offset = uoffset - fp->idx->offs[i].uaddr; + assert( fp->block_offset <= fp->block_length ); // todo: skipped, unindexed, blocks + } + fp->uncompressed_address = uoffset; + return 0; +} + +long bgzf_utell(BGZF *fp) +{ + return fp->uncompressed_address; // currently maintained only when reading +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/bgzip.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,284 @@ +/* bgzip.c -- Block compression/decompression utility. + + Copyright (C) 2008, 2009 Broad Institute / Massachusetts Institute of Technology + Copyright (C) 2010, 2013, 2014 Genome Research Ltd. + + Permission is hereby granted, free of charge, to any person obtaining a copy + of this software and associated documentation files (the "Software"), to deal + in the Software without restriction, including without limitation the rights + to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + copies of the Software, and to permit persons to whom the Software is + furnished to do so, subject to the following conditions: + + The above copyright notices and this permission notice shall be included in + all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + THE SOFTWARE. +*/ + +#include <stdlib.h> +#include <string.h> +#include <stdio.h> +#include <fcntl.h> +#include <unistd.h> +#include <errno.h> +#include <stdarg.h> +#include <getopt.h> +#include <sys/select.h> +#include <sys/stat.h> +#include "htslib/bgzf.h" +#include "htslib/hts.h" + +static const int WINDOW_SIZE = 64 * 1024; + +static void error(const char *format, ...) +{ + va_list ap; + va_start(ap, format); + vfprintf(stderr, format, ap); + va_end(ap); + exit(EXIT_FAILURE); +} + +static int write_open(const char *fn, int is_forced) +{ + int fd = -1; + char c; + if (!is_forced) { + if ((fd = open(fn, O_WRONLY | O_CREAT | O_TRUNC | O_EXCL, 0666)) < 0 && errno == EEXIST) { + fprintf(stderr, "[bgzip] %s already exists; do you wish to overwrite (y or n)? ", fn); + if ( scanf("%c", &c) != 1 ) c = 'n'; + if (c != 'Y' && c != 'y') { + fprintf(stderr, "[bgzip] not overwritten\n"); + exit(EXIT_FAILURE); + } + } + } + if (fd < 0) { + if ((fd = open(fn, O_WRONLY | O_CREAT | O_TRUNC, 0666)) < 0) { + fprintf(stderr, "[bgzip] %s: Fail to write\n", fn); + exit(EXIT_FAILURE); + } + } + return fd; +} + +static int bgzip_main_usage(void) +{ + fprintf(stderr, "\n"); + fprintf(stderr, "Version: %s\n", hts_version()); + fprintf(stderr, "Usage: bgzip [OPTIONS] [FILE] ...\n"); + fprintf(stderr, "Options:\n"); + fprintf(stderr, " -b, --offset INT decompress at virtual file pointer (0-based uncompressed offset)\n"); + fprintf(stderr, " -c, --stdout write on standard output, keep original files unchanged\n"); + fprintf(stderr, " -d, --decompress decompress\n"); + fprintf(stderr, " -f, --force overwrite files without asking\n"); + fprintf(stderr, " -h, --help give this help\n"); + fprintf(stderr, " -i, --index compress and create BGZF index\n"); + fprintf(stderr, " -I, --index-name FILE name of BGZF index file [file.gz.gzi]\n"); + fprintf(stderr, " -r, --reindex (re)index compressed file\n"); + fprintf(stderr, " -s, --size INT decompress INT bytes (uncompressed size)\n"); + fprintf(stderr, "\n"); + return 1; +} + +int main(int argc, char **argv) +{ + int c, compress, pstdout, is_forced, index = 0, reindex = 0; + BGZF *fp; + void *buffer; + long start, end, size; + char *index_fname = NULL; + + static struct option loptions[] = + { + {"help",0,0,'h'}, + {"offset",1,0,'b'}, + {"stdout",0,0,'c'}, + {"decompress",0,0,'d'}, + {"force",0,0,'f'}, + {"index",0,0,'i'}, + {"index-name",1,0,'I'}, + {"reindex",0,0,'r'}, + {"size",1,0,'s'}, + {0,0,0,0} + }; + + compress = 1; pstdout = 0; start = 0; size = -1; end = -1; is_forced = 0; + while((c = getopt_long(argc, argv, "cdh?fb:s:iI:r",loptions,NULL)) >= 0){ + switch(c){ + case 'd': compress = 0; break; + case 'c': pstdout = 1; break; + case 'b': start = atol(optarg); compress = 0; pstdout = 1; break; + case 's': size = atol(optarg); pstdout = 1; break; + case 'f': is_forced = 1; break; + case 'i': index = 1; break; + case 'I': index_fname = optarg; break; + case 'r': reindex = 1; compress = 0; break; + case 'h': + case '?': return bgzip_main_usage(); + } + } + if (size >= 0) end = start + size; + if (end >= 0 && end < start) { + fprintf(stderr, "[bgzip] Illegal region: [%ld, %ld]\n", start, end); + return 1; + } + if (compress == 1) { + struct stat sbuf; + int f_src = fileno(stdin); + int f_dst = fileno(stdout); + + if ( argc>optind ) + { + if ( stat(argv[optind],&sbuf)<0 ) + { + fprintf(stderr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]); + return 1; + } + + if ((f_src = open(argv[optind], O_RDONLY)) < 0) { + fprintf(stderr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]); + return 1; + } + + if (pstdout) + f_dst = fileno(stdout); + else + { + char *name = malloc(strlen(argv[optind]) + 5); + strcpy(name, argv[optind]); + strcat(name, ".gz"); + f_dst = write_open(name, is_forced); + free(name); + if (f_dst < 0) return 1; + } + } + else if (!pstdout && isatty(fileno((FILE *)stdout)) ) + return bgzip_main_usage(); + else if ( index && !index_fname ) + { + fprintf(stderr, "[bgzip] Index file name expected when writing to stdout\n"); + return 1; + } + + fp = bgzf_fdopen(f_dst, "w"); + if ( index ) bgzf_index_build_init(fp); + buffer = malloc(WINDOW_SIZE); + while ((c = read(f_src, buffer, WINDOW_SIZE)) > 0) + if (bgzf_write(fp, buffer, c) < 0) error("Could not write %d bytes: Error %d\n", c, fp->errcode); + // f_dst will be closed here + if ( index ) + { + if ( index_fname ) bgzf_index_dump(fp, index_fname, NULL); + else bgzf_index_dump(fp, argv[optind], ".gz.gzi"); + } + if (bgzf_close(fp) < 0) error("Close failed: Error %d", fp->errcode); + if (argc > optind && !pstdout) unlink(argv[optind]); + free(buffer); + close(f_src); + return 0; + } + else if ( reindex ) + { + if ( argc>optind ) + { + fp = bgzf_open(argv[optind], "r"); + if ( !fp ) error("[bgzip] Could not open file: %s\n", argv[optind]); + } + else + { + if ( !index_fname ) error("[bgzip] Index file name expected when reading from stdin\n"); + fp = bgzf_fdopen(fileno(stdin), "r"); + if ( !fp ) error("[bgzip] Could not read from stdin: %s\n", strerror(errno)); + } + + buffer = malloc(BGZF_BLOCK_SIZE); + bgzf_index_build_init(fp); + int ret; + while ( (ret=bgzf_read(fp, buffer, BGZF_BLOCK_SIZE))>0 ) ; + free(buffer); + if ( ret<0 ) error("Is the file gzipped or bgzipped? The latter is required for indexing.\n"); + + if ( index_fname ) + bgzf_index_dump(fp, index_fname, NULL); + else + bgzf_index_dump(fp, argv[optind], ".gzi"); + + if ( bgzf_close(fp)<0 ) error("Close failed: Error %d\n",fp->errcode); + return 0; + } + else + { + struct stat sbuf; + int f_dst; + + if ( argc>optind ) + { + if ( stat(argv[optind],&sbuf)<0 ) + { + fprintf(stderr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]); + return 1; + } + char *name; + int len = strlen(argv[optind]); + if ( strcmp(argv[optind]+len-3,".gz") ) + { + fprintf(stderr, "[bgzip] %s: unknown suffix -- ignored\n", argv[optind]); + return 1; + } + fp = bgzf_open(argv[optind], "r"); + if (fp == NULL) { + fprintf(stderr, "[bgzip] Could not open file: %s\n", argv[optind]); + return 1; + } + + if (pstdout) { + f_dst = fileno(stdout); + } + else { + name = strdup(argv[optind]); + name[strlen(name) - 3] = '\0'; + f_dst = write_open(name, is_forced); + free(name); + } + } + else if (!pstdout && isatty(fileno((FILE *)stdin)) ) + return bgzip_main_usage(); + else + { + f_dst = fileno(stdout); + fp = bgzf_fdopen(fileno(stdin), "r"); + if (fp == NULL) { + fprintf(stderr, "[bgzip] Could not read from stdin: %s\n", strerror(errno)); + return 1; + } + } + buffer = malloc(WINDOW_SIZE); + if ( start>0 ) + { + if ( bgzf_index_load(fp, argv[optind], ".gzi") < 0 ) error("Could not load index: %s.gzi\n", argv[optind]); + if ( bgzf_useek(fp, start, SEEK_SET) < 0 ) error("Could not seek to %d-th (uncompressd) byte\n", start); + } + while (1) { + if (end < 0) c = bgzf_read(fp, buffer, WINDOW_SIZE); + else c = bgzf_read(fp, buffer, (end - start > WINDOW_SIZE)? WINDOW_SIZE:(end - start)); + if (c == 0) break; + if (c < 0) error("Could not read %d bytes: Error %d\n", (end - start > WINDOW_SIZE)? WINDOW_SIZE:(end - start), fp->errcode); + start += c; + if ( write(f_dst, buffer, c) != c ) error("Could not write %d bytes\n", c); + if (end >= 0 && start >= end) break; + } + free(buffer); + if (bgzf_close(fp) < 0) error("Close failed: Error %d\n",fp->errcode); + if (!pstdout) unlink(argv[optind]); + return 0; + } + return 0; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/config.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3 @@ +#define _USE_KNETFILE +#define BGZF_CACHE +#define BGZF_MT
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/config.mk Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,72 @@ +# Optional configure Makefile overrides for htslib. +# +# Copyright (C) 2015 Genome Research Ltd. +# +# Author: John Marshall <jm18@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +# This is config.mk. Generated from config.mk.in by configure. +# +# If you use configure, this file overrides variables and augments rules +# in the Makefile to reflect your configuration choices. If you don't run +# configure, the main Makefile contains suitable conservative defaults. + +prefix = /usr/local +exec_prefix = ${prefix} +bindir = ${exec_prefix}/bin +includedir = ${prefix}/include +libdir = ${exec_prefix}/lib +datarootdir = ${prefix}/share +mandir = ${datarootdir}/man + +CC = gcc +RANLIB = ranlib + +CFLAGS = -g -O2 +LDFLAGS = +LDLIBS = + + +# ifeq/.../endif, +=, and target-specific variables are GNU Make-specific. +# If you don't have GNU Make, comment out this conditional and note that +# to enable iRODS you will need to implement the following elsewhere. +ifeq "iRODS-disabled" "iRODS-enabled" + +IRODS_HOME ?= /disabled + +EXTRA_CPPFLAGS_IRODS = \ + -I$(IRODS_HOME)/lib/api/include \ + -I$(IRODS_HOME)/lib/core/include \ + -I$(IRODS_HOME)/lib/md5/include \ + -I$(IRODS_HOME)/lib/sha1/include \ + -I$(IRODS_HOME)/server/core/include \ + -I$(IRODS_HOME)/server/drivers/include \ + -I$(IRODS_HOME)/server/icat/include + +LDFLAGS += -L$(IRODS_HOME)/lib/core/obj +LDLIBS += -lRodsAPIs -lgssapi_krb5 + +LIBHTS_OBJS += hfile_irods.o + +hfile.o hfile.pico: CPPFLAGS += -DHAVE_IRODS + +hfile_irods.o hfile_irods.pico: CPPFLAGS += $(EXTRA_CPPFLAGS_IRODS) + +endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/config.mk.in Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,72 @@ +# Optional configure Makefile overrides for htslib. +# +# Copyright (C) 2015 Genome Research Ltd. +# +# Author: John Marshall <jm18@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +# This is @configure_input@ +# +# If you use configure, this file overrides variables and augments rules +# in the Makefile to reflect your configuration choices. If you don't run +# configure, the main Makefile contains suitable conservative defaults. + +prefix = @prefix@ +exec_prefix = @exec_prefix@ +bindir = @bindir@ +includedir = @includedir@ +libdir = @libdir@ +datarootdir = @datarootdir@ +mandir = @mandir@ + +CC = @CC@ +RANLIB = @RANLIB@ + +CFLAGS = @CFLAGS@ +LDFLAGS = @LDFLAGS@ +LDLIBS = @LIBS@ + + +# ifeq/.../endif, +=, and target-specific variables are GNU Make-specific. +# If you don't have GNU Make, comment out this conditional and note that +# to enable iRODS you will need to implement the following elsewhere. +ifeq "iRODS-@irods@" "iRODS-enabled" + +@define_IRODS_HOME@ + +EXTRA_CPPFLAGS_IRODS = \ + -I$(IRODS_HOME)/lib/api/include \ + -I$(IRODS_HOME)/lib/core/include \ + -I$(IRODS_HOME)/lib/md5/include \ + -I$(IRODS_HOME)/lib/sha1/include \ + -I$(IRODS_HOME)/server/core/include \ + -I$(IRODS_HOME)/server/drivers/include \ + -I$(IRODS_HOME)/server/icat/include + +LDFLAGS += -L$(IRODS_HOME)/lib/core/obj +LDLIBS += -lRodsAPIs -lgssapi_krb5 + +LIBHTS_OBJS += hfile_irods.o + +hfile.o hfile.pico: CPPFLAGS += -DHAVE_IRODS + +hfile_irods.o hfile_irods.pico: CPPFLAGS += $(EXTRA_CPPFLAGS_IRODS) + +endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/configure Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,4012 @@ +#! /bin/sh +# Guess values for system-dependent variables and create Makefiles. +# Generated by GNU Autoconf 2.68 for HTSlib 1.2.1. +# +# Report bugs to <samtools-help@lists.sourceforge.net>. +# +# +# Copyright (C) 1992, 1993, 1994, 1995, 1996, 1998, 1999, 2000, 2001, +# 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010 Free Software +# Foundation, Inc. +# +# +# This configure script is free software; the Free Software Foundation +# gives unlimited permission to copy, distribute and modify it. +# +# Portions copyright (C) 2015 Genome Research Ltd. +# +# This configure script is free software: you are free to change and +# redistribute it. There is NO WARRANTY, to the extent permitted by law. +## -------------------- ## +## M4sh Initialization. ## +## -------------------- ## + +# Be more Bourne compatible +DUALCASE=1; export DUALCASE # for MKS sh +if test -n "${ZSH_VERSION+set}" && (emulate sh) >/dev/null 2>&1; then : + emulate sh + NULLCMD=: + # Pre-4.2 versions of Zsh do word splitting on ${1+"$@"}, which + # is contrary to our usage. Disable this feature. + alias -g '${1+"$@"}'='"$@"' + setopt NO_GLOB_SUBST +else + case `(set -o) 2>/dev/null` in #( + *posix*) : + set -o posix ;; #( + *) : + ;; +esac +fi + + +as_nl=' +' +export as_nl +# Printing a long string crashes Solaris 7 /usr/bin/printf. +as_echo='\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\' +as_echo=$as_echo$as_echo$as_echo$as_echo$as_echo +as_echo=$as_echo$as_echo$as_echo$as_echo$as_echo$as_echo +# Prefer a ksh shell builtin over an external printf program on Solaris, +# but without wasting forks for bash or zsh. +if test -z "$BASH_VERSION$ZSH_VERSION" \ + && (test "X`print -r -- $as_echo`" = "X$as_echo") 2>/dev/null; then + as_echo='print -r --' + as_echo_n='print -rn --' +elif (test "X`printf %s $as_echo`" = "X$as_echo") 2>/dev/null; then + as_echo='printf %s\n' + as_echo_n='printf %s' +else + if test "X`(/usr/ucb/echo -n -n $as_echo) 2>/dev/null`" = "X-n $as_echo"; then + as_echo_body='eval /usr/ucb/echo -n "$1$as_nl"' + as_echo_n='/usr/ucb/echo -n' + else + as_echo_body='eval expr "X$1" : "X\\(.*\\)"' + as_echo_n_body='eval + arg=$1; + case $arg in #( + *"$as_nl"*) + expr "X$arg" : "X\\(.*\\)$as_nl"; + arg=`expr "X$arg" : ".*$as_nl\\(.*\\)"`;; + esac; + expr "X$arg" : "X\\(.*\\)" | tr -d "$as_nl" + ' + export as_echo_n_body + as_echo_n='sh -c $as_echo_n_body as_echo' + fi + export as_echo_body + as_echo='sh -c $as_echo_body as_echo' +fi + +# The user is always right. +if test "${PATH_SEPARATOR+set}" != set; then + PATH_SEPARATOR=: + (PATH='/bin;/bin'; FPATH=$PATH; sh -c :) >/dev/null 2>&1 && { + (PATH='/bin:/bin'; FPATH=$PATH; sh -c :) >/dev/null 2>&1 || + PATH_SEPARATOR=';' + } +fi + + +# IFS +# We need space, tab and new line, in precisely that order. Quoting is +# there to prevent editors from complaining about space-tab. +# (If _AS_PATH_WALK were called with IFS unset, it would disable word +# splitting by setting IFS to empty value.) +IFS=" "" $as_nl" + +# Find who we are. Look in the path if we contain no directory separator. +as_myself= +case $0 in #(( + *[\\/]* ) as_myself=$0 ;; + *) as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + test -r "$as_dir/$0" && as_myself=$as_dir/$0 && break + done +IFS=$as_save_IFS + + ;; +esac +# We did not find ourselves, most probably we were run as `sh COMMAND' +# in which case we are not to be found in the path. +if test "x$as_myself" = x; then + as_myself=$0 +fi +if test ! -f "$as_myself"; then + $as_echo "$as_myself: error: cannot find myself; rerun with an absolute file name" >&2 + exit 1 +fi + +# Unset variables that we do not need and which cause bugs (e.g. in +# pre-3.0 UWIN ksh). But do not cause bugs in bash 2.01; the "|| exit 1" +# suppresses any "Segmentation fault" message there. '((' could +# trigger a bug in pdksh 5.2.14. +for as_var in BASH_ENV ENV MAIL MAILPATH +do eval test x\${$as_var+set} = xset \ + && ( (unset $as_var) || exit 1) >/dev/null 2>&1 && unset $as_var || : +done +PS1='$ ' +PS2='> ' +PS4='+ ' + +# NLS nuisances. +LC_ALL=C +export LC_ALL +LANGUAGE=C +export LANGUAGE + +# CDPATH. +(unset CDPATH) >/dev/null 2>&1 && unset CDPATH + +if test "x$CONFIG_SHELL" = x; then + as_bourne_compatible="if test -n \"\${ZSH_VERSION+set}\" && (emulate sh) >/dev/null 2>&1; then : + emulate sh + NULLCMD=: + # Pre-4.2 versions of Zsh do word splitting on \${1+\"\$@\"}, which + # is contrary to our usage. Disable this feature. + alias -g '\${1+\"\$@\"}'='\"\$@\"' + setopt NO_GLOB_SUBST +else + case \`(set -o) 2>/dev/null\` in #( + *posix*) : + set -o posix ;; #( + *) : + ;; +esac +fi +" + as_required="as_fn_return () { (exit \$1); } +as_fn_success () { as_fn_return 0; } +as_fn_failure () { as_fn_return 1; } +as_fn_ret_success () { return 0; } +as_fn_ret_failure () { return 1; } + +exitcode=0 +as_fn_success || { exitcode=1; echo as_fn_success failed.; } +as_fn_failure && { exitcode=1; echo as_fn_failure succeeded.; } +as_fn_ret_success || { exitcode=1; echo as_fn_ret_success failed.; } +as_fn_ret_failure && { exitcode=1; echo as_fn_ret_failure succeeded.; } +if ( set x; as_fn_ret_success y && test x = \"\$1\" ); then : + +else + exitcode=1; echo positional parameters were not saved. +fi +test x\$exitcode = x0 || exit 1" + as_suggested=" as_lineno_1=";as_suggested=$as_suggested$LINENO;as_suggested=$as_suggested" as_lineno_1a=\$LINENO + as_lineno_2=";as_suggested=$as_suggested$LINENO;as_suggested=$as_suggested" as_lineno_2a=\$LINENO + eval 'test \"x\$as_lineno_1'\$as_run'\" != \"x\$as_lineno_2'\$as_run'\" && + test \"x\`expr \$as_lineno_1'\$as_run' + 1\`\" = \"x\$as_lineno_2'\$as_run'\"' || exit 1" + if (eval "$as_required") 2>/dev/null; then : + as_have_required=yes +else + as_have_required=no +fi + if test x$as_have_required = xyes && (eval "$as_suggested") 2>/dev/null; then : + +else + as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +as_found=false +for as_dir in /bin$PATH_SEPARATOR/usr/bin$PATH_SEPARATOR$PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + as_found=: + case $as_dir in #( + /*) + for as_base in sh bash ksh sh5; do + # Try only shells that exist, to save several forks. + as_shell=$as_dir/$as_base + if { test -f "$as_shell" || test -f "$as_shell.exe"; } && + { $as_echo "$as_bourne_compatible""$as_required" | as_run=a "$as_shell"; } 2>/dev/null; then : + CONFIG_SHELL=$as_shell as_have_required=yes + if { $as_echo "$as_bourne_compatible""$as_suggested" | as_run=a "$as_shell"; } 2>/dev/null; then : + break 2 +fi +fi + done;; + esac + as_found=false +done +$as_found || { if { test -f "$SHELL" || test -f "$SHELL.exe"; } && + { $as_echo "$as_bourne_compatible""$as_required" | as_run=a "$SHELL"; } 2>/dev/null; then : + CONFIG_SHELL=$SHELL as_have_required=yes +fi; } +IFS=$as_save_IFS + + + if test "x$CONFIG_SHELL" != x; then : + # We cannot yet assume a decent shell, so we have to provide a + # neutralization value for shells without unset; and this also + # works around shells that cannot unset nonexistent variables. + # Preserve -v and -x to the replacement shell. + BASH_ENV=/dev/null + ENV=/dev/null + (unset BASH_ENV) >/dev/null 2>&1 && unset BASH_ENV ENV + export CONFIG_SHELL + case $- in # (((( + *v*x* | *x*v* ) as_opts=-vx ;; + *v* ) as_opts=-v ;; + *x* ) as_opts=-x ;; + * ) as_opts= ;; + esac + exec "$CONFIG_SHELL" $as_opts "$as_myself" ${1+"$@"} +fi + + if test x$as_have_required = xno; then : + $as_echo "$0: This script requires a shell more modern than all" + $as_echo "$0: the shells that I found on your system." + if test x${ZSH_VERSION+set} = xset ; then + $as_echo "$0: In particular, zsh $ZSH_VERSION has bugs and should" + $as_echo "$0: be upgraded to zsh 4.3.4 or later." + else + $as_echo "$0: Please tell bug-autoconf@gnu.org and +$0: samtools-help@lists.sourceforge.net about your system, +$0: including any error possibly output before this +$0: message. Then install a modern shell, or manually run +$0: the script under such a shell if you do have one." + fi + exit 1 +fi +fi +fi +SHELL=${CONFIG_SHELL-/bin/sh} +export SHELL +# Unset more variables known to interfere with behavior of common tools. +CLICOLOR_FORCE= GREP_OPTIONS= +unset CLICOLOR_FORCE GREP_OPTIONS + +## --------------------- ## +## M4sh Shell Functions. ## +## --------------------- ## +# as_fn_unset VAR +# --------------- +# Portably unset VAR. +as_fn_unset () +{ + { eval $1=; unset $1;} +} +as_unset=as_fn_unset + +# as_fn_set_status STATUS +# ----------------------- +# Set $? to STATUS, without forking. +as_fn_set_status () +{ + return $1 +} # as_fn_set_status + +# as_fn_exit STATUS +# ----------------- +# Exit the shell with STATUS, even in a "trap 0" or "set -e" context. +as_fn_exit () +{ + set +e + as_fn_set_status $1 + exit $1 +} # as_fn_exit + +# as_fn_mkdir_p +# ------------- +# Create "$as_dir" as a directory, including parents if necessary. +as_fn_mkdir_p () +{ + + case $as_dir in #( + -*) as_dir=./$as_dir;; + esac + test -d "$as_dir" || eval $as_mkdir_p || { + as_dirs= + while :; do + case $as_dir in #( + *\'*) as_qdir=`$as_echo "$as_dir" | sed "s/'/'\\\\\\\\''/g"`;; #'( + *) as_qdir=$as_dir;; + esac + as_dirs="'$as_qdir' $as_dirs" + as_dir=`$as_dirname -- "$as_dir" || +$as_expr X"$as_dir" : 'X\(.*[^/]\)//*[^/][^/]*/*$' \| \ + X"$as_dir" : 'X\(//\)[^/]' \| \ + X"$as_dir" : 'X\(//\)$' \| \ + X"$as_dir" : 'X\(/\)' \| . 2>/dev/null || +$as_echo X"$as_dir" | + sed '/^X\(.*[^/]\)\/\/*[^/][^/]*\/*$/{ + s//\1/ + q + } + /^X\(\/\/\)[^/].*/{ + s//\1/ + q + } + /^X\(\/\/\)$/{ + s//\1/ + q + } + /^X\(\/\).*/{ + s//\1/ + q + } + s/.*/./; q'` + test -d "$as_dir" && break + done + test -z "$as_dirs" || eval "mkdir $as_dirs" + } || test -d "$as_dir" || as_fn_error $? "cannot create directory $as_dir" + + +} # as_fn_mkdir_p +# as_fn_append VAR VALUE +# ---------------------- +# Append the text in VALUE to the end of the definition contained in VAR. Take +# advantage of any shell optimizations that allow amortized linear growth over +# repeated appends, instead of the typical quadratic growth present in naive +# implementations. +if (eval "as_var=1; as_var+=2; test x\$as_var = x12") 2>/dev/null; then : + eval 'as_fn_append () + { + eval $1+=\$2 + }' +else + as_fn_append () + { + eval $1=\$$1\$2 + } +fi # as_fn_append + +# as_fn_arith ARG... +# ------------------ +# Perform arithmetic evaluation on the ARGs, and store the result in the +# global $as_val. Take advantage of shells that can avoid forks. The arguments +# must be portable across $(()) and expr. +if (eval "test \$(( 1 + 1 )) = 2") 2>/dev/null; then : + eval 'as_fn_arith () + { + as_val=$(( $* )) + }' +else + as_fn_arith () + { + as_val=`expr "$@" || test $? -eq 1` + } +fi # as_fn_arith + + +# as_fn_error STATUS ERROR [LINENO LOG_FD] +# ---------------------------------------- +# Output "`basename $0`: error: ERROR" to stderr. If LINENO and LOG_FD are +# provided, also output the error to LOG_FD, referencing LINENO. Then exit the +# script with STATUS, using 1 if that was 0. +as_fn_error () +{ + as_status=$1; test $as_status -eq 0 && as_status=1 + if test "$4"; then + as_lineno=${as_lineno-"$3"} as_lineno_stack=as_lineno_stack=$as_lineno_stack + $as_echo "$as_me:${as_lineno-$LINENO}: error: $2" >&$4 + fi + $as_echo "$as_me: error: $2" >&2 + as_fn_exit $as_status +} # as_fn_error + +if expr a : '\(a\)' >/dev/null 2>&1 && + test "X`expr 00001 : '.*\(...\)'`" = X001; then + as_expr=expr +else + as_expr=false +fi + +if (basename -- /) >/dev/null 2>&1 && test "X`basename -- / 2>&1`" = "X/"; then + as_basename=basename +else + as_basename=false +fi + +if (as_dir=`dirname -- /` && test "X$as_dir" = X/) >/dev/null 2>&1; then + as_dirname=dirname +else + as_dirname=false +fi + +as_me=`$as_basename -- "$0" || +$as_expr X/"$0" : '.*/\([^/][^/]*\)/*$' \| \ + X"$0" : 'X\(//\)$' \| \ + X"$0" : 'X\(/\)' \| . 2>/dev/null || +$as_echo X/"$0" | + sed '/^.*\/\([^/][^/]*\)\/*$/{ + s//\1/ + q + } + /^X\/\(\/\/\)$/{ + s//\1/ + q + } + /^X\/\(\/\).*/{ + s//\1/ + q + } + s/.*/./; q'` + +# Avoid depending upon Character Ranges. +as_cr_letters='abcdefghijklmnopqrstuvwxyz' +as_cr_LETTERS='ABCDEFGHIJKLMNOPQRSTUVWXYZ' +as_cr_Letters=$as_cr_letters$as_cr_LETTERS +as_cr_digits='0123456789' +as_cr_alnum=$as_cr_Letters$as_cr_digits + + + as_lineno_1=$LINENO as_lineno_1a=$LINENO + as_lineno_2=$LINENO as_lineno_2a=$LINENO + eval 'test "x$as_lineno_1'$as_run'" != "x$as_lineno_2'$as_run'" && + test "x`expr $as_lineno_1'$as_run' + 1`" = "x$as_lineno_2'$as_run'"' || { + # Blame Lee E. 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"./$cache_file";; + esac + fi +else + { $as_echo "$as_me:${as_lineno-$LINENO}: creating cache $cache_file" >&5 +$as_echo "$as_me: creating cache $cache_file" >&6;} + >$cache_file +fi + +# Check that the precious variables saved in the cache have kept the same +# value. +ac_cache_corrupted=false +for ac_var in $ac_precious_vars; do + eval ac_old_set=\$ac_cv_env_${ac_var}_set + eval ac_new_set=\$ac_env_${ac_var}_set + eval ac_old_val=\$ac_cv_env_${ac_var}_value + eval ac_new_val=\$ac_env_${ac_var}_value + case $ac_old_set,$ac_new_set in + set,) + { $as_echo "$as_me:${as_lineno-$LINENO}: error: \`$ac_var' was set to \`$ac_old_val' in the previous run" >&5 +$as_echo "$as_me: error: \`$ac_var' was set to \`$ac_old_val' in the previous run" >&2;} + ac_cache_corrupted=: ;; + ,set) + { $as_echo "$as_me:${as_lineno-$LINENO}: error: \`$ac_var' was not set in the previous run" >&5 +$as_echo "$as_me: error: \`$ac_var' was not set in the previous run" >&2;} + ac_cache_corrupted=: ;; + ,);; + *) + if test "x$ac_old_val" != "x$ac_new_val"; then + # differences in whitespace do not lead to failure. + ac_old_val_w=`echo x $ac_old_val` + ac_new_val_w=`echo x $ac_new_val` + if test "$ac_old_val_w" != "$ac_new_val_w"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: error: \`$ac_var' has changed since the previous run:" >&5 +$as_echo "$as_me: error: \`$ac_var' has changed since the previous run:" >&2;} + ac_cache_corrupted=: + else + { $as_echo "$as_me:${as_lineno-$LINENO}: warning: ignoring whitespace changes in \`$ac_var' since the previous run:" >&5 +$as_echo "$as_me: warning: ignoring whitespace changes in \`$ac_var' since the previous run:" >&2;} + eval $ac_var=\$ac_old_val + fi + { $as_echo "$as_me:${as_lineno-$LINENO}: former value: \`$ac_old_val'" >&5 +$as_echo "$as_me: former value: \`$ac_old_val'" >&2;} + { $as_echo "$as_me:${as_lineno-$LINENO}: current value: \`$ac_new_val'" >&5 +$as_echo "$as_me: current value: \`$ac_new_val'" >&2;} + fi;; + esac + # Pass precious variables to config.status. + if test "$ac_new_set" = set; then + case $ac_new_val in + *\'*) ac_arg=$ac_var=`$as_echo "$ac_new_val" | sed "s/'/'\\\\\\\\''/g"` ;; + *) ac_arg=$ac_var=$ac_new_val ;; + esac + case " $ac_configure_args " in + *" '$ac_arg' "*) ;; # Avoid dups. Use of quotes ensures accuracy. + *) as_fn_append ac_configure_args " '$ac_arg'" ;; + esac + fi +done +if $ac_cache_corrupted; then + { $as_echo "$as_me:${as_lineno-$LINENO}: error: in \`$ac_pwd':" >&5 +$as_echo "$as_me: error: in \`$ac_pwd':" >&2;} + { $as_echo "$as_me:${as_lineno-$LINENO}: error: changes in the environment can compromise the build" >&5 +$as_echo "$as_me: error: changes in the environment can compromise the build" >&2;} + as_fn_error $? "run \`make distclean' and/or \`rm $cache_file' and start over" "$LINENO" 5 +fi +## -------------------- ## +## Main body of script. ## +## -------------------- ## + +ac_ext=c +ac_cpp='$CPP $CPPFLAGS' +ac_compile='$CC -c $CFLAGS $CPPFLAGS conftest.$ac_ext >&5' +ac_link='$CC -o conftest$ac_exeext $CFLAGS $CPPFLAGS $LDFLAGS conftest.$ac_ext $LIBS >&5' +ac_compiler_gnu=$ac_cv_c_compiler_gnu + + + + + + +ac_ext=c +ac_cpp='$CPP $CPPFLAGS' +ac_compile='$CC -c $CFLAGS $CPPFLAGS conftest.$ac_ext >&5' +ac_link='$CC -o conftest$ac_exeext $CFLAGS $CPPFLAGS $LDFLAGS conftest.$ac_ext $LIBS >&5' +ac_compiler_gnu=$ac_cv_c_compiler_gnu +if test -n "$ac_tool_prefix"; then + # Extract the first word of "${ac_tool_prefix}gcc", so it can be a program name with args. +set dummy ${ac_tool_prefix}gcc; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_CC+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$CC"; then + ac_cv_prog_CC="$CC" # Let the user override the test. +else +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + ac_cv_prog_CC="${ac_tool_prefix}gcc" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +fi +fi +CC=$ac_cv_prog_CC +if test -n "$CC"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $CC" >&5 +$as_echo "$CC" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + +fi +if test -z "$ac_cv_prog_CC"; then + ac_ct_CC=$CC + # Extract the first word of "gcc", so it can be a program name with args. +set dummy gcc; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_ac_ct_CC+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$ac_ct_CC"; then + ac_cv_prog_ac_ct_CC="$ac_ct_CC" # Let the user override the test. +else +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + ac_cv_prog_ac_ct_CC="gcc" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +fi +fi +ac_ct_CC=$ac_cv_prog_ac_ct_CC +if test -n "$ac_ct_CC"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_ct_CC" >&5 +$as_echo "$ac_ct_CC" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + if test "x$ac_ct_CC" = x; then + CC="" + else + case $cross_compiling:$ac_tool_warned in +yes:) +{ $as_echo "$as_me:${as_lineno-$LINENO}: WARNING: using cross tools not prefixed with host triplet" >&5 +$as_echo "$as_me: WARNING: using cross tools not prefixed with host triplet" >&2;} +ac_tool_warned=yes ;; +esac + CC=$ac_ct_CC + fi +else + CC="$ac_cv_prog_CC" +fi + +if test -z "$CC"; then + if test -n "$ac_tool_prefix"; then + # Extract the first word of "${ac_tool_prefix}cc", so it can be a program name with args. +set dummy ${ac_tool_prefix}cc; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_CC+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$CC"; then + ac_cv_prog_CC="$CC" # Let the user override the test. +else +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + ac_cv_prog_CC="${ac_tool_prefix}cc" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +fi +fi +CC=$ac_cv_prog_CC +if test -n "$CC"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $CC" >&5 +$as_echo "$CC" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + + fi +fi +if test -z "$CC"; then + # Extract the first word of "cc", so it can be a program name with args. +set dummy cc; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_CC+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$CC"; then + ac_cv_prog_CC="$CC" # Let the user override the test. +else + ac_prog_rejected=no +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + if test "$as_dir/$ac_word$ac_exec_ext" = "/usr/ucb/cc"; then + ac_prog_rejected=yes + continue + fi + ac_cv_prog_CC="cc" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +if test $ac_prog_rejected = yes; then + # We found a bogon in the path, so make sure we never use it. + set dummy $ac_cv_prog_CC + shift + if test $# != 0; then + # We chose a different compiler from the bogus one. + # However, it has the same basename, so the bogon will be chosen + # first if we set CC to just the basename; use the full file name. + shift + ac_cv_prog_CC="$as_dir/$ac_word${1+' '}$@" + fi +fi +fi +fi +CC=$ac_cv_prog_CC +if test -n "$CC"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $CC" >&5 +$as_echo "$CC" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + +fi +if test -z "$CC"; then + if test -n "$ac_tool_prefix"; then + for ac_prog in cl.exe + do + # Extract the first word of "$ac_tool_prefix$ac_prog", so it can be a program name with args. +set dummy $ac_tool_prefix$ac_prog; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_CC+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$CC"; then + ac_cv_prog_CC="$CC" # Let the user override the test. +else +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + ac_cv_prog_CC="$ac_tool_prefix$ac_prog" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +fi +fi +CC=$ac_cv_prog_CC +if test -n "$CC"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $CC" >&5 +$as_echo "$CC" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + + test -n "$CC" && break + done +fi +if test -z "$CC"; then + ac_ct_CC=$CC + for ac_prog in cl.exe +do + # Extract the first word of "$ac_prog", so it can be a program name with args. +set dummy $ac_prog; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_ac_ct_CC+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$ac_ct_CC"; then + ac_cv_prog_ac_ct_CC="$ac_ct_CC" # Let the user override the test. +else +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + ac_cv_prog_ac_ct_CC="$ac_prog" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +fi +fi +ac_ct_CC=$ac_cv_prog_ac_ct_CC +if test -n "$ac_ct_CC"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_ct_CC" >&5 +$as_echo "$ac_ct_CC" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + + test -n "$ac_ct_CC" && break +done + + if test "x$ac_ct_CC" = x; then + CC="" + else + case $cross_compiling:$ac_tool_warned in +yes:) +{ $as_echo "$as_me:${as_lineno-$LINENO}: WARNING: using cross tools not prefixed with host triplet" >&5 +$as_echo "$as_me: WARNING: using cross tools not prefixed with host triplet" >&2;} +ac_tool_warned=yes ;; +esac + CC=$ac_ct_CC + fi +fi + +fi + + +test -z "$CC" && { { $as_echo "$as_me:${as_lineno-$LINENO}: error: in \`$ac_pwd':" >&5 +$as_echo "$as_me: error: in \`$ac_pwd':" >&2;} +as_fn_error $? "no acceptable C compiler found in \$PATH +See \`config.log' for more details" "$LINENO" 5; } + +# Provide some information about the compiler. +$as_echo "$as_me:${as_lineno-$LINENO}: checking for C compiler version" >&5 +set X $ac_compile +ac_compiler=$2 +for ac_option in --version -v -V -qversion; do + { { ac_try="$ac_compiler $ac_option >&5" +case "(($ac_try" in + *\"* | *\`* | *\\*) ac_try_echo=\$ac_try;; + *) ac_try_echo=$ac_try;; +esac +eval ac_try_echo="\"\$as_me:${as_lineno-$LINENO}: $ac_try_echo\"" +$as_echo "$ac_try_echo"; } >&5 + (eval "$ac_compiler $ac_option >&5") 2>conftest.err + ac_status=$? + if test -s conftest.err; then + sed '10a\ +... rest of stderr output deleted ... + 10q' conftest.err >conftest.er1 + cat conftest.er1 >&5 + fi + rm -f conftest.er1 conftest.err + $as_echo "$as_me:${as_lineno-$LINENO}: \$? = $ac_status" >&5 + test $ac_status = 0; } +done + +cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ + +int +main () +{ + + ; + return 0; +} +_ACEOF +ac_clean_files_save=$ac_clean_files +ac_clean_files="$ac_clean_files a.out a.out.dSYM a.exe b.out" +# Try to create an executable without -o first, disregard a.out. +# It will help us diagnose broken compilers, and finding out an intuition +# of exeext. +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking whether the C compiler works" >&5 +$as_echo_n "checking whether the C compiler works... " >&6; } +ac_link_default=`$as_echo "$ac_link" | sed 's/ -o *conftest[^ ]*//'` + +# The possible output files: +ac_files="a.out conftest.exe conftest a.exe a_out.exe b.out conftest.*" + +ac_rmfiles= +for ac_file in $ac_files +do + case $ac_file in + *.$ac_ext | *.xcoff | *.tds | *.d | *.pdb | *.xSYM | *.bb | *.bbg | *.map | *.inf | *.dSYM | *.o | *.obj ) ;; + * ) ac_rmfiles="$ac_rmfiles $ac_file";; + esac +done +rm -f $ac_rmfiles + +if { { ac_try="$ac_link_default" +case "(($ac_try" in + *\"* | *\`* | *\\*) ac_try_echo=\$ac_try;; + *) ac_try_echo=$ac_try;; +esac +eval ac_try_echo="\"\$as_me:${as_lineno-$LINENO}: $ac_try_echo\"" +$as_echo "$ac_try_echo"; } >&5 + (eval "$ac_link_default") 2>&5 + ac_status=$? + $as_echo "$as_me:${as_lineno-$LINENO}: \$? = $ac_status" >&5 + test $ac_status = 0; }; then : + # Autoconf-2.13 could set the ac_cv_exeext variable to `no'. +# So ignore a value of `no', otherwise this would lead to `EXEEXT = no' +# in a Makefile. We should not override ac_cv_exeext if it was cached, +# so that the user can short-circuit this test for compilers unknown to +# Autoconf. +for ac_file in $ac_files '' +do + test -f "$ac_file" || continue + case $ac_file in + *.$ac_ext | *.xcoff | *.tds | *.d | *.pdb | *.xSYM | *.bb | *.bbg | *.map | *.inf | *.dSYM | *.o | *.obj ) + ;; + [ab].out ) + # We found the default executable, but exeext='' is most + # certainly right. + break;; + *.* ) + if test "${ac_cv_exeext+set}" = set && test "$ac_cv_exeext" != no; + then :; else + ac_cv_exeext=`expr "$ac_file" : '[^.]*\(\..*\)'` + fi + # We set ac_cv_exeext here because the later test for it is not + # safe: cross compilers may not add the suffix if given an `-o' + # argument, so we may need to know it at that point already. + # Even if this section looks crufty: it has the advantage of + # actually working. + break;; + * ) + break;; + esac +done +test "$ac_cv_exeext" = no && ac_cv_exeext= + +else + ac_file='' +fi +if test -z "$ac_file"; then : + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +$as_echo "$as_me: failed program was:" >&5 +sed 's/^/| /' conftest.$ac_ext >&5 + +{ { $as_echo "$as_me:${as_lineno-$LINENO}: error: in \`$ac_pwd':" >&5 +$as_echo "$as_me: error: in \`$ac_pwd':" >&2;} +as_fn_error 77 "C compiler cannot create executables +See \`config.log' for more details" "$LINENO" 5; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: yes" >&5 +$as_echo "yes" >&6; } +fi +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for C compiler default output file name" >&5 +$as_echo_n "checking for C compiler default output file name... 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For instance with Cygwin, `ls conftest' will +# work properly (i.e., refer to `conftest.exe'), while it won't with +# `rm'. +for ac_file in conftest.exe conftest conftest.*; do + test -f "$ac_file" || continue + case $ac_file in + *.$ac_ext | *.xcoff | *.tds | *.d | *.pdb | *.xSYM | *.bb | *.bbg | *.map | *.inf | *.dSYM | *.o | *.obj ) ;; + *.* ) ac_cv_exeext=`expr "$ac_file" : '[^.]*\(\..*\)'` + break;; + * ) break;; + esac +done +else + { { $as_echo "$as_me:${as_lineno-$LINENO}: error: in \`$ac_pwd':" >&5 +$as_echo "$as_me: error: in \`$ac_pwd':" >&2;} +as_fn_error $? "cannot compute suffix of executables: cannot compile and link +See \`config.log' for more details" "$LINENO" 5; } +fi +rm -f conftest conftest$ac_cv_exeext +{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_exeext" >&5 +$as_echo "$ac_cv_exeext" >&6; } + +rm -f conftest.$ac_ext +EXEEXT=$ac_cv_exeext +ac_exeext=$EXEEXT +cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ +#include <stdio.h> +int +main () +{ +FILE *f = fopen ("conftest.out", "w"); + return ferror (f) || fclose (f) != 0; + + ; + return 0; +} +_ACEOF +ac_clean_files="$ac_clean_files conftest.out" +# Check that the compiler produces executables we can run. If not, either +# the compiler is broken, or we cross compile. +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking whether we are cross compiling" >&5 +$as_echo_n "checking whether we are cross compiling... " >&6; } +if test "$cross_compiling" != yes; then + { { ac_try="$ac_link" +case "(($ac_try" in + *\"* | *\`* | *\\*) ac_try_echo=\$ac_try;; + *) ac_try_echo=$ac_try;; +esac +eval ac_try_echo="\"\$as_me:${as_lineno-$LINENO}: $ac_try_echo\"" +$as_echo "$ac_try_echo"; } >&5 + (eval "$ac_link") 2>&5 + ac_status=$? + $as_echo "$as_me:${as_lineno-$LINENO}: \$? = $ac_status" >&5 + test $ac_status = 0; } + if { ac_try='./conftest$ac_cv_exeext' + { { case "(($ac_try" in + *\"* | *\`* | *\\*) ac_try_echo=\$ac_try;; + *) ac_try_echo=$ac_try;; +esac +eval ac_try_echo="\"\$as_me:${as_lineno-$LINENO}: $ac_try_echo\"" +$as_echo "$ac_try_echo"; } >&5 + (eval "$ac_try") 2>&5 + ac_status=$? + $as_echo "$as_me:${as_lineno-$LINENO}: \$? = $ac_status" >&5 + test $ac_status = 0; }; }; then + cross_compiling=no + else + if test "$cross_compiling" = maybe; then + cross_compiling=yes + else + { { $as_echo "$as_me:${as_lineno-$LINENO}: error: in \`$ac_pwd':" >&5 +$as_echo "$as_me: error: in \`$ac_pwd':" >&2;} +as_fn_error $? "cannot run C compiled programs. +If you meant to cross compile, use \`--host'. +See \`config.log' for more details" "$LINENO" 5; } + fi + fi +fi +{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $cross_compiling" >&5 +$as_echo "$cross_compiling" >&6; } + +rm -f conftest.$ac_ext conftest$ac_cv_exeext conftest.out +ac_clean_files=$ac_clean_files_save +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for suffix of object files" >&5 +$as_echo_n "checking for suffix of object files... " >&6; } +if ${ac_cv_objext+:} false; then : + $as_echo_n "(cached) " >&6 +else + cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ + +int +main () +{ + + ; + return 0; +} +_ACEOF +rm -f conftest.o conftest.obj +if { { ac_try="$ac_compile" +case "(($ac_try" in + *\"* | *\`* | *\\*) ac_try_echo=\$ac_try;; + *) ac_try_echo=$ac_try;; +esac +eval ac_try_echo="\"\$as_me:${as_lineno-$LINENO}: $ac_try_echo\"" +$as_echo "$ac_try_echo"; } >&5 + (eval "$ac_compile") 2>&5 + ac_status=$? + $as_echo "$as_me:${as_lineno-$LINENO}: \$? = $ac_status" >&5 + test $ac_status = 0; }; then : + for ac_file in conftest.o conftest.obj conftest.*; do + test -f "$ac_file" || continue; + case $ac_file in + *.$ac_ext | *.xcoff | *.tds | *.d | *.pdb | *.xSYM | *.bb | *.bbg | *.map | *.inf | *.dSYM ) ;; + *) ac_cv_objext=`expr "$ac_file" : '.*\.\(.*\)'` + break;; + esac +done +else + $as_echo "$as_me: failed program was:" >&5 +sed 's/^/| /' conftest.$ac_ext >&5 + +{ { $as_echo "$as_me:${as_lineno-$LINENO}: error: in \`$ac_pwd':" >&5 +$as_echo "$as_me: error: in \`$ac_pwd':" >&2;} +as_fn_error $? "cannot compute suffix of object files: cannot compile +See \`config.log' for more details" "$LINENO" 5; } +fi +rm -f conftest.$ac_cv_objext conftest.$ac_ext +fi +{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_objext" >&5 +$as_echo "$ac_cv_objext" >&6; } +OBJEXT=$ac_cv_objext +ac_objext=$OBJEXT +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking whether we are using the GNU C compiler" >&5 +$as_echo_n "checking whether we are using the GNU C compiler... " >&6; } +if ${ac_cv_c_compiler_gnu+:} false; then : + $as_echo_n "(cached) " >&6 +else + cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ + +int +main () +{ +#ifndef __GNUC__ + choke me +#endif + + ; + return 0; +} +_ACEOF +if ac_fn_c_try_compile "$LINENO"; then : + ac_compiler_gnu=yes +else + ac_compiler_gnu=no +fi +rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext +ac_cv_c_compiler_gnu=$ac_compiler_gnu + +fi +{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_c_compiler_gnu" >&5 +$as_echo "$ac_cv_c_compiler_gnu" >&6; } +if test $ac_compiler_gnu = yes; then + GCC=yes +else + GCC= +fi +ac_test_CFLAGS=${CFLAGS+set} +ac_save_CFLAGS=$CFLAGS +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking whether $CC accepts -g" >&5 +$as_echo_n "checking whether $CC accepts -g... " >&6; } +if ${ac_cv_prog_cc_g+:} false; then : + $as_echo_n "(cached) " >&6 +else + ac_save_c_werror_flag=$ac_c_werror_flag + ac_c_werror_flag=yes + ac_cv_prog_cc_g=no + CFLAGS="-g" + cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ + +int +main () +{ + + ; + return 0; +} +_ACEOF +if ac_fn_c_try_compile "$LINENO"; then : + ac_cv_prog_cc_g=yes +else + CFLAGS="" + cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ + +int +main () +{ + + ; + return 0; +} +_ACEOF +if ac_fn_c_try_compile "$LINENO"; then : + +else + ac_c_werror_flag=$ac_save_c_werror_flag + CFLAGS="-g" + cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ + +int +main () +{ + + ; + return 0; +} +_ACEOF +if ac_fn_c_try_compile "$LINENO"; then : + ac_cv_prog_cc_g=yes +fi +rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext +fi +rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext +fi +rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext + ac_c_werror_flag=$ac_save_c_werror_flag +fi +{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_prog_cc_g" >&5 +$as_echo "$ac_cv_prog_cc_g" >&6; } +if test "$ac_test_CFLAGS" = set; then + CFLAGS=$ac_save_CFLAGS +elif test $ac_cv_prog_cc_g = yes; then + if test "$GCC" = yes; then + CFLAGS="-g -O2" + else + CFLAGS="-g" + fi +else + if test "$GCC" = yes; then + CFLAGS="-O2" + else + CFLAGS= + fi +fi +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $CC option to accept ISO C89" >&5 +$as_echo_n "checking for $CC option to accept ISO C89... " >&6; } +if ${ac_cv_prog_cc_c89+:} false; then : + $as_echo_n "(cached) " >&6 +else + ac_cv_prog_cc_c89=no +ac_save_CC=$CC +cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ +#include <stdarg.h> +#include <stdio.h> +#include <sys/types.h> +#include <sys/stat.h> +/* Most of the following tests are stolen from RCS 5.7's src/conf.sh. */ +struct buf { int x; }; +FILE * (*rcsopen) (struct buf *, struct stat *, int); +static char *e (p, i) + char **p; + int i; +{ + return p[i]; +} +static char *f (char * (*g) (char **, int), char **p, ...) +{ + char *s; + va_list v; + va_start (v,p); + s = g (p, va_arg (v,int)); + va_end (v); + return s; +} + +/* OSF 4.0 Compaq cc is some sort of almost-ANSI by default. It has + function prototypes and stuff, but not '\xHH' hex character constants. + These don't provoke an error unfortunately, instead are silently treated + as 'x'. The following induces an error, until -std is added to get + proper ANSI mode. Curiously '\x00'!='x' always comes out true, for an + array size at least. It's necessary to write '\x00'==0 to get something + that's true only with -std. */ +int osf4_cc_array ['\x00' == 0 ? 1 : -1]; + +/* IBM C 6 for AIX is almost-ANSI by default, but it replaces macro parameters + inside strings and character constants. */ +#define FOO(x) 'x' +int xlc6_cc_array[FOO(a) == 'x' ? 1 : -1]; + +int test (int i, double x); +struct s1 {int (*f) (int a);}; +struct s2 {int (*f) (double a);}; +int pairnames (int, char **, FILE *(*)(struct buf *, struct stat *, int), int, int); +int argc; +char **argv; +int +main () +{ +return f (e, argv, 0) != argv[0] || f (e, argv, 1) != argv[1]; + ; + return 0; +} +_ACEOF +for ac_arg in '' -qlanglvl=extc89 -qlanglvl=ansi -std \ + -Ae "-Aa -D_HPUX_SOURCE" "-Xc -D__EXTENSIONS__" +do + CC="$ac_save_CC $ac_arg" + if ac_fn_c_try_compile "$LINENO"; then : + ac_cv_prog_cc_c89=$ac_arg +fi +rm -f core conftest.err conftest.$ac_objext + test "x$ac_cv_prog_cc_c89" != "xno" && break +done +rm -f conftest.$ac_ext +CC=$ac_save_CC + +fi +# AC_CACHE_VAL +case "x$ac_cv_prog_cc_c89" in + x) + { $as_echo "$as_me:${as_lineno-$LINENO}: result: none needed" >&5 +$as_echo "none needed" >&6; } ;; + xno) + { $as_echo "$as_me:${as_lineno-$LINENO}: result: unsupported" >&5 +$as_echo "unsupported" >&6; } ;; + *) + CC="$CC $ac_cv_prog_cc_c89" + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_prog_cc_c89" >&5 +$as_echo "$ac_cv_prog_cc_c89" >&6; } ;; +esac +if test "x$ac_cv_prog_cc_c89" != xno; then : + +fi + +ac_ext=c +ac_cpp='$CPP $CPPFLAGS' +ac_compile='$CC -c $CFLAGS $CPPFLAGS conftest.$ac_ext >&5' +ac_link='$CC -o conftest$ac_exeext $CFLAGS $CPPFLAGS $LDFLAGS conftest.$ac_ext $LIBS >&5' +ac_compiler_gnu=$ac_cv_c_compiler_gnu + +if test -n "$ac_tool_prefix"; then + # Extract the first word of "${ac_tool_prefix}ranlib", so it can be a program name with args. +set dummy ${ac_tool_prefix}ranlib; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_RANLIB+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$RANLIB"; then + ac_cv_prog_RANLIB="$RANLIB" # Let the user override the test. +else +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + ac_cv_prog_RANLIB="${ac_tool_prefix}ranlib" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +fi +fi +RANLIB=$ac_cv_prog_RANLIB +if test -n "$RANLIB"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $RANLIB" >&5 +$as_echo "$RANLIB" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + +fi +if test -z "$ac_cv_prog_RANLIB"; then + ac_ct_RANLIB=$RANLIB + # Extract the first word of "ranlib", so it can be a program name with args. +set dummy ranlib; ac_word=$2 +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5 +$as_echo_n "checking for $ac_word... " >&6; } +if ${ac_cv_prog_ac_ct_RANLIB+:} false; then : + $as_echo_n "(cached) " >&6 +else + if test -n "$ac_ct_RANLIB"; then + ac_cv_prog_ac_ct_RANLIB="$ac_ct_RANLIB" # Let the user override the test. +else +as_save_IFS=$IFS; IFS=$PATH_SEPARATOR +for as_dir in $PATH +do + IFS=$as_save_IFS + test -z "$as_dir" && as_dir=. + for ac_exec_ext in '' $ac_executable_extensions; do + if { test -f "$as_dir/$ac_word$ac_exec_ext" && $as_test_x "$as_dir/$ac_word$ac_exec_ext"; }; then + ac_cv_prog_ac_ct_RANLIB="ranlib" + $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5 + break 2 + fi +done + done +IFS=$as_save_IFS + +fi +fi +ac_ct_RANLIB=$ac_cv_prog_ac_ct_RANLIB +if test -n "$ac_ct_RANLIB"; then + { $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_ct_RANLIB" >&5 +$as_echo "$ac_ct_RANLIB" >&6; } +else + { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5 +$as_echo "no" >&6; } +fi + + if test "x$ac_ct_RANLIB" = x; then + RANLIB=":" + else + case $cross_compiling:$ac_tool_warned in +yes:) +{ $as_echo "$as_me:${as_lineno-$LINENO}: WARNING: using cross tools not prefixed with host triplet" >&5 +$as_echo "$as_me: WARNING: using cross tools not prefixed with host triplet" >&2;} +ac_tool_warned=yes ;; +esac + RANLIB=$ac_ct_RANLIB + fi +else + RANLIB="$ac_cv_prog_RANLIB" +fi + + + +# Check whether --with-irods was given. +if test "${with_irods+set}" = set; then : + withval=$with_irods; case $withval in + no) irods=disabled ;; + yes) irods=enabled ;; + *) irods=enabled; IRODS_HOME=$withval ;; + esac +else + irods=disabled +fi + + +save_LIBS=$LIBS +zlib_devel=ok + +ac_fn_c_check_header_compile "$LINENO" "zlib.h" "ac_cv_header_zlib_h" "; +" +if test "x$ac_cv_header_zlib_h" = xyes; then : + +else + zlib_devel=missing +fi + + +{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for inflate in -lz" >&5 +$as_echo_n "checking for inflate in -lz... " >&6; } +if ${ac_cv_lib_z_inflate+:} false; then : + $as_echo_n "(cached) " >&6 +else + ac_check_lib_save_LIBS=$LIBS +LIBS="-lz $LIBS" +cat confdefs.h - <<_ACEOF >conftest.$ac_ext +/* end confdefs.h. */ + +/* Override any GCC internal prototype to avoid an error. + Use char because int might match the return type of a GCC + builtin and then its argument prototype would still apply. */ +#ifdef __cplusplus +extern "C" +#endif +char inflate (); +int +main () +{ +return inflate (); + ; + return 0; +} +_ACEOF +if ac_fn_c_try_link "$LINENO"; then : + ac_cv_lib_z_inflate=yes +else + ac_cv_lib_z_inflate=no +fi +rm -f core conftest.err conftest.$ac_objext \ + conftest$ac_exeext conftest.$ac_ext +LIBS=$ac_check_lib_save_LIBS +fi +{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_lib_z_inflate" >&5 +$as_echo "$ac_cv_lib_z_inflate" >&6; } +if test "x$ac_cv_lib_z_inflate" = xyes; then : + cat >>confdefs.h <<_ACEOF +#define HAVE_LIBZ 1 +_ACEOF + + LIBS="-lz $LIBS" + +else + zlib_devel=missing +fi + +LIBS=$save_LIBS + +if test $zlib_devel != ok; then + as_fn_error $? "zlib development files not found + +HTSlib uses compression routines from the zlib library <http://zlib.net>. +Building HTSlib requires zlib development files to be installed on the build +machine; you may need to ensure a package such as zlib1g-dev (on Debian or +Ubuntu Linux) or zlib-devel (on RPM-based Linux distributions) is installed. + +FAILED. This error must be resolved in order to build HTSlib successfully." "$LINENO" 5 +fi + +if test $irods = enabled; then + # TODO Also test whether we require libgssapi_krb5 and AC_CHECK_LIB it + save_LDFLAGS=$LDFLAGS + LDFLAGS="$LDFLAGS -L$IRODS_HOME/lib/core/obj" + { $as_echo "$as_me:${as_lineno-$LINENO}: checking for getRodsEnvFileName in -lRodsAPIs" >&5 +$as_echo_n "checking for getRodsEnvFileName in -lRodsAPIs... 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"cannot create directory $as_dir" + + +} # as_fn_mkdir_p +if mkdir -p . 2>/dev/null; then + as_mkdir_p='mkdir -p "$as_dir"' +else + test -d ./-p && rmdir ./-p + as_mkdir_p=false +fi + +if test -x / >/dev/null 2>&1; then + as_test_x='test -x' +else + if ls -dL / >/dev/null 2>&1; then + as_ls_L_option=L + else + as_ls_L_option= + fi + as_test_x=' + eval sh -c '\'' + if test -d "$1"; then + test -d "$1/."; + else + case $1 in #( + -*)set "./$1";; + esac; + case `ls -ld'$as_ls_L_option' "$1" 2>/dev/null` in #(( + ???[sx]*):;;*)false;;esac;fi + '\'' sh + ' +fi +as_executable_p=$as_test_x + +# Sed expression to map a string onto a valid CPP name. +as_tr_cpp="eval sed 'y%*$as_cr_letters%P$as_cr_LETTERS%;s%[^_$as_cr_alnum]%_%g'" + +# Sed expression to map a string onto a valid variable name. +as_tr_sh="eval sed 'y%*+%pp%;s%[^_$as_cr_alnum]%_%g'" + + +exec 6>&1 +## ----------------------------------- ## +## Main body of $CONFIG_STATUS script. ## +## ----------------------------------- ## +_ASEOF +test $as_write_fail = 0 && chmod +x $CONFIG_STATUS || ac_write_fail=1 + +cat >>$CONFIG_STATUS <<\_ACEOF || ac_write_fail=1 +# Save the log message, to keep $0 and so on meaningful, and to +# report actual input values of CONFIG_FILES etc. instead of their +# values after options handling. +ac_log=" +This file was extended by HTSlib $as_me 1.2.1, which was +generated by GNU Autoconf 2.68. 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"missing file argument" ;; + esac + as_fn_append CONFIG_FILES " '$ac_optarg'" + ac_need_defaults=false;; + --he | --h | --help | --hel | -h ) + $as_echo "$ac_cs_usage"; exit ;; + -q | -quiet | --quiet | --quie | --qui | --qu | --q \ + | -silent | --silent | --silen | --sile | --sil | --si | --s) + ac_cs_silent=: ;; + + # This is an error. + -*) as_fn_error $? "unrecognized option: \`$1' +Try \`$0 --help' for more information." ;; + + *) as_fn_append ac_config_targets " $1" + ac_need_defaults=false ;; + + esac + shift +done + +ac_configure_extra_args= + +if $ac_cs_silent; then + exec 6>/dev/null + ac_configure_extra_args="$ac_configure_extra_args --silent" +fi + +_ACEOF +cat >>$CONFIG_STATUS <<_ACEOF || ac_write_fail=1 +if \$ac_cs_recheck; then + set X '$SHELL' '$0' $ac_configure_args \$ac_configure_extra_args --no-create --no-recursion + shift + \$as_echo "running CONFIG_SHELL=$SHELL \$*" >&6 + CONFIG_SHELL='$SHELL' + export CONFIG_SHELL + exec "\$@" +fi + +_ACEOF +cat >>$CONFIG_STATUS <<\_ACEOF || ac_write_fail=1 +exec 5>>config.log +{ + echo + sed 'h;s/./-/g;s/^.../## /;s/...$/ ##/;p;x;p;x' <<_ASBOX +## Running $as_me. ## +_ASBOX + $as_echo "$ac_log" +} >&5 + +_ACEOF +cat >>$CONFIG_STATUS <<_ACEOF || ac_write_fail=1 +_ACEOF + +cat >>$CONFIG_STATUS <<\_ACEOF || ac_write_fail=1 + +# Handling of arguments. +for ac_config_target in $ac_config_targets +do + case $ac_config_target in + "config.mk") CONFIG_FILES="$CONFIG_FILES config.mk" ;; + + *) as_fn_error $? "invalid argument: \`$ac_config_target'" "$LINENO" 5;; + esac +done + + +# If the user did not use the arguments to specify the items to instantiate, +# then the envvar interface is used. Set only those that are not. +# We use the long form for the default assignment because of an extremely +# bizarre bug on SunOS 4.1.3. +if $ac_need_defaults; then + test "${CONFIG_FILES+set}" = set || CONFIG_FILES=$config_files +fi + +# Have a temporary directory for convenience. Make it in the build tree +# simply because there is no reason against having it here, and in addition, +# creating and moving files from /tmp can sometimes cause problems. +# Hook for its removal unless debugging. +# Note that there is a small window in which the directory will not be cleaned: +# after its creation but before its name has been assigned to `$tmp'. +$debug || +{ + tmp= ac_tmp= + trap 'exit_status=$? + : "${ac_tmp:=$tmp}" + { test ! -d "$ac_tmp" || rm -fr "$ac_tmp"; } && exit $exit_status +' 0 + trap 'as_fn_exit 1' 1 2 13 15 +} +# Create a (secure) tmp directory for tmp files. + +{ + tmp=`(umask 077 && mktemp -d "./confXXXXXX") 2>/dev/null` && + test -d "$tmp" +} || +{ + tmp=./conf$$-$RANDOM + (umask 077 && mkdir "$tmp") +} || as_fn_error $? "cannot create a temporary directory in ." "$LINENO" 5 +ac_tmp=$tmp + +# Set up the scripts for CONFIG_FILES section. +# No need to generate them if there are no CONFIG_FILES. +# This happens for instance with `./config.status config.h'. +if test -n "$CONFIG_FILES"; then + + +ac_cr=`echo X | tr X '\015'` +# On cygwin, bash can eat \r inside `` if the user requested igncr. +# But we know of no other shell where ac_cr would be empty at this +# point, so we can use a bashism as a fallback. +if test "x$ac_cr" = x; then + eval ac_cr=\$\'\\r\' +fi +ac_cs_awk_cr=`$AWK 'BEGIN { print "a\rb" }' </dev/null 2>/dev/null` +if test "$ac_cs_awk_cr" = "a${ac_cr}b"; then + ac_cs_awk_cr='\\r' +else + ac_cs_awk_cr=$ac_cr +fi + +echo 'BEGIN {' >"$ac_tmp/subs1.awk" && +_ACEOF + + +{ + echo "cat >conf$$subs.awk <<_ACEOF" && + echo "$ac_subst_vars" | sed 's/.*/&!$&$ac_delim/' && + echo "_ACEOF" +} >conf$$subs.sh || + as_fn_error $? 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"could not setup config files machinery" "$LINENO" 5 +_ACEOF + +# VPATH may cause trouble with some makes, so we remove sole $(srcdir), +# ${srcdir} and @srcdir@ entries from VPATH if srcdir is ".", strip leading and +# trailing colons and then remove the whole line if VPATH becomes empty +# (actually we leave an empty line to preserve line numbers). +if test "x$srcdir" = x.; then + ac_vpsub='/^[ ]*VPATH[ ]*=[ ]*/{ +h +s/// +s/^/:/ +s/[ ]*$/:/ +s/:\$(srcdir):/:/g +s/:\${srcdir}:/:/g +s/:@srcdir@:/:/g +s/^:*// +s/:*$// +x +s/\(=[ ]*\).*/\1/ +G +s/\n// +s/^[^=]*=[ ]*$// +}' +fi + +cat >>$CONFIG_STATUS <<\_ACEOF || ac_write_fail=1 +fi # test -n "$CONFIG_FILES" + + +eval set X " :F $CONFIG_FILES " +shift +for ac_tag +do + case $ac_tag in + :[FHLC]) ac_mode=$ac_tag; continue;; + esac + case $ac_mode$ac_tag in + :[FHL]*:*);; + :L* | :C*:*) as_fn_error $? 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"write failure creating $CONFIG_STATUS" "$LINENO" 5 + + +# configure is writing to config.log, and then calls config.status. +# config.status does its own redirection, appending to config.log. +# Unfortunately, on DOS this fails, as config.log is still kept open +# by configure, so config.status won't be able to write to it; its +# output is simply discarded. So we exec the FD to /dev/null, +# effectively closing config.log, so it can be properly (re)opened and +# appended to by config.status. When coming back to configure, we +# need to make the FD available again. +if test "$no_create" != yes; then + ac_cs_success=: + ac_config_status_args= + test "$silent" = yes && + ac_config_status_args="$ac_config_status_args --quiet" + exec 5>/dev/null + $SHELL $CONFIG_STATUS $ac_config_status_args || ac_cs_success=false + exec 5>>config.log + # Use ||, not &&, to avoid exiting from the if with $? = 1, which + # would make configure fail if this is the last instruction. + $ac_cs_success || as_fn_exit 1 +fi +if test -n "$ac_unrecognized_opts" && test "$enable_option_checking" != no; then + { $as_echo "$as_me:${as_lineno-$LINENO}: WARNING: unrecognized options: $ac_unrecognized_opts" >&5 +$as_echo "$as_me: WARNING: unrecognized options: $ac_unrecognized_opts" >&2;} +fi +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/configure.ac Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,93 @@ +# Configure script for htslib, a C library for high-throughput sequencing data. +# +# Copyright (C) 2015 Genome Research Ltd. +# +# Author: John Marshall <jm18@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +dnl Process this file with autoconf to produce a configure script +AC_INIT([HTSlib], m4_esyscmd_s([make print-version]), + [samtools-help@lists.sourceforge.net], [], [http://www.htslib.org/]) +AC_PREREQ(2.63) dnl This version introduced 4-argument AC_CHECK_HEADER +AC_CONFIG_SRCDIR(hts.c) + +dnl Copyright notice to be copied into the generated configure script +AC_COPYRIGHT([Portions copyright (C) 2015 Genome Research Ltd. + +This configure script is free software: you are free to change and +redistribute it. There is NO WARRANTY, to the extent permitted by law.]) + +AC_PROG_CC +AC_PROG_RANLIB + +AC_ARG_WITH([irods], + [AS_HELP_STRING([[--with-irods[=DIR]]], + [use RodsAPIs library (in DIR) to support iRODS URLs])], + [case $withval in + no) irods=disabled ;; + yes) irods=enabled ;; + *) irods=enabled; IRODS_HOME=$withval ;; + esac], + [irods=disabled]) + +save_LIBS=$LIBS +zlib_devel=ok +dnl Set a trivial non-empty INCLUDES to avoid excess default includes tests +AC_CHECK_HEADER([zlib.h], [], [zlib_devel=missing], [;]) +AC_CHECK_LIB(z, inflate, [], [zlib_devel=missing]) +LIBS=$save_LIBS + +if test $zlib_devel != ok; then + AC_MSG_ERROR([zlib development files not found + +HTSlib uses compression routines from the zlib library <http://zlib.net>. +Building HTSlib requires zlib development files to be installed on the build +machine; you may need to ensure a package such as zlib1g-dev (on Debian or +Ubuntu Linux) or zlib-devel (on RPM-based Linux distributions) is installed. + +FAILED. This error must be resolved in order to build HTSlib successfully.]) +fi + +if test $irods = enabled; then + # TODO Also test whether we require libgssapi_krb5 and AC_CHECK_LIB it + save_LDFLAGS=$LDFLAGS + LDFLAGS="$LDFLAGS -L$IRODS_HOME/lib/core/obj" + AC_CHECK_LIB([RodsAPIs], [getRodsEnvFileName], + [case $with_irods in + yes) define_IRODS_HOME='# Uses $(IRODS_HOME) from the environment' ;; + *) define_IRODS_HOME="IRODS_HOME = $with_irods" ;; + esac], + [AC_MSG_ERROR([iRODS development files not found + +Support for iRODS URLs requires the libRodsAPI client library and headers. +Configure with --with-irods=DIR (or just --with-irods if \$IRODS_HOME has +been exported with a suitable value), where DIR is the base of an iRODS tree +such that the library is present as DIR/lib/core/obj/libRodsAPI.* and headers +are present under DIR/lib/api/include and so on.])], + [-lgssapi_krb5 -lpthread]) + LDFLAGS=$save_LDFLAGS +else + define_IRODS_HOME='IRODS_HOME ?= /disabled' +fi +AC_SUBST([irods]) +AC_SUBST([define_IRODS_HOME]) + +AC_CONFIG_FILES(config.mk) +AC_OUTPUT
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,63 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/*! \file + * CRAM interface. + * + * Consider using the higher level hts_*() API for programs that wish to + * be file format agnostic (see htslib/hts.h). + * + * This API should be used for CRAM specific code. The specifics of the + * public API are implemented in cram_io.h, cram_encode.h and cram_decode.h + * although these should not be included directly (use this file instead). + */ + +#ifdef __cplusplus +extern "C" { +#endif + +#ifndef _CRAM_H_ +#define _CRAM_H_ + +#include "cram/cram_samtools.h" +#include "cram/sam_header.h" +#include "cram_structs.h" +#include "cram_io.h" +#include "cram_encode.h" +#include "cram_decode.h" +#include "cram_stats.h" +#include "cram_codecs.h" +#include "cram_index.h" + +#endif + +#ifdef __cplusplus +} +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_codecs.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1846 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* + * FIXME: add checking of cram_external_type to return NULL on unsupported + * {codec,type} tuples. + */ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdlib.h> +#include <string.h> +#include <assert.h> +#include <limits.h> + +#include "cram/cram.h" + +static char *codec2str(enum cram_encoding codec) { + switch (codec) { + case E_NULL: return "NULL"; + case E_EXTERNAL: return "EXTERNAL"; + case E_GOLOMB: return "GOLOMB"; + case E_HUFFMAN: return "HUFFMAN"; + case E_BYTE_ARRAY_LEN: return "BYTE_ARRAY_LEN"; + case E_BYTE_ARRAY_STOP: return "BYTE_ARRAY_STOP"; + case E_BETA: return "BETA"; + case E_SUBEXP: return "SUBEXP"; + case E_GOLOMB_RICE: return "GOLOMB_RICE"; + case E_GAMMA: return "GAMMA"; + } + + return "(unknown)"; +} + +/* + * --------------------------------------------------------------------------- + * Block bit-level I/O functions. + * All defined static here to promote easy inlining by the compiler. + */ + +#if 0 +/* Get a single bit, MSB first */ +static signed int get_bit_MSB(cram_block *block) { + unsigned int val; + + if (block->byte > block->alloc) + return -1; + + val = block->data[block->byte] >> block->bit; + if (--block->bit == -1) { + block->bit = 7; + block->byte++; + //printf("(%02X)", block->data[block->byte]); + } + + //printf("-B%d-", val&1); + + return val & 1; +} +#endif + +/* + * Count number of successive 0 and 1 bits + */ +static int get_one_bits_MSB(cram_block *block) { + int n = 0, b; + do { + b = block->data[block->byte] >> block->bit; + if (--block->bit == -1) { + block->bit = 7; + block->byte++; + } + n++; + } while (b&1); + + return n-1; +} + +static int get_zero_bits_MSB(cram_block *block) { + int n = 0, b; + do { + b = block->data[block->byte] >> block->bit; + if (--block->bit == -1) { + block->bit = 7; + block->byte++; + } + n++; + } while (!(b&1)); + + return n-1; +} + +#if 0 +/* Stores a single bit */ +static void store_bit_MSB(cram_block *block, unsigned int bit) { + if (block->byte >= block->alloc) { + block->alloc = block->alloc ? block->alloc*2 : 1024; + block->data = realloc(block->data, block->alloc); + } + + if (bit) + block->data[block->byte] |= (1 << block->bit); + + if (--block->bit == -1) { + block->bit = 7; + block->byte++; + block->data[block->byte] = 0; + } +} +#endif + +#if 0 +/* Rounds to the next whole byte boundary first */ +static void store_bytes_MSB(cram_block *block, char *bytes, int len) { + if (block->bit != 7) { + block->bit = 7; + block->byte++; + } + + while (block->byte + len >= block->alloc) { + block->alloc = block->alloc ? block->alloc*2 : 1024; + block->data = realloc(block->data, block->alloc); + } + + memcpy(&block->data[block->byte], bytes, len); + block->byte += len; +} +#endif + +/* Local optimised copy for inlining */ +static inline unsigned int get_bits_MSB(cram_block *block, int nbits) { + unsigned int val = 0; + int i; + +#if 0 + // Fits within the current byte */ + if (nbits <= block->bit+1) { + val = (block->data[block->byte]>>(block->bit-(nbits-1))) & ((1<<nbits)-1); + if ((block->bit -= nbits) == -1) { + block->bit = 7; + block->byte++; + } + return val; + } + + // partial first byte + val = block->data[block->byte] & ((1<<(block->bit+1))-1); + nbits -= block->bit+1; + block->bit = 7; + block->byte++; + + // whole middle bytes + while (nbits >= 8) { + val = (val << 8) | block->data[block->byte++]; + nbits -= 8; + } + + val <<= nbits; + val |= (block->data[block->byte]>>(block->bit-(nbits-1))) & ((1<<nbits)-1); + block->bit -= nbits; + return val; +#endif + +#if 0 + /* Inefficient implementation! */ + //printf("{"); + for (i = 0; i < nbits; i++) + //val = (val << 1) | get_bit_MSB(block); + GET_BIT_MSB(block, val); +#endif + +#if 1 + /* Combination of 1st two methods */ + if (nbits <= block->bit+1) { + val = (block->data[block->byte]>>(block->bit-(nbits-1))) & ((1<<nbits)-1); + if ((block->bit -= nbits) == -1) { + block->bit = 7; + block->byte++; + } + return val; + } + + switch(nbits) { +// case 15: GET_BIT_MSB(block, val); +// case 14: GET_BIT_MSB(block, val); +// case 13: GET_BIT_MSB(block, val); +// case 12: GET_BIT_MSB(block, val); +// case 11: GET_BIT_MSB(block, val); +// case 10: GET_BIT_MSB(block, val); +// case 9: GET_BIT_MSB(block, val); + case 8: GET_BIT_MSB(block, val); + case 7: GET_BIT_MSB(block, val); + case 6: GET_BIT_MSB(block, val); + case 5: GET_BIT_MSB(block, val); + case 4: GET_BIT_MSB(block, val); + case 3: GET_BIT_MSB(block, val); + case 2: GET_BIT_MSB(block, val); + case 1: GET_BIT_MSB(block, val); + break; + + default: + for (i = 0; i < nbits; i++) + //val = (val << 1) | get_bit_MSB(block); + GET_BIT_MSB(block, val); + } +#endif + + //printf("=0x%x}", val); + + return val; +} + +/* + * Can store up to 24-bits worth of data encoded in an integer value + * Possibly we'd want to have a less optimal store_bits function when dealing + * with nbits > 24, but for now we assume the codes generated are never + * that big. (Given this is only possible with 121392 or more + * characters with exactly the correct frequency distribution we check + * for it elsewhere.) + */ +static int store_bits_MSB(cram_block *block, unsigned int val, int nbits) { + /* fprintf(stderr, " store_bits: %02x %d\n", val, nbits); */ + + /* + * Use slow mode until we tweak the huffman generator to never generate + * codes longer than 24-bits. + */ + unsigned int mask; + + if (block->byte+4 >= block->alloc) { + if (block->byte) { + block->alloc *= 2; + block->data = realloc(block->data, block->alloc + 4); + if (!block->data) + return -1; + } else { + block->alloc = 1024; + block->data = realloc(block->data, block->alloc + 4); + if (!block->data) + return -1; + block->data[0] = 0; // initialise first byte of buffer + } + } + + /* fits in current bit-field */ + if (nbits <= block->bit+1) { + block->data[block->byte] |= (val << (block->bit+1-nbits)); + if ((block->bit-=nbits) == -1) { + block->bit = 7; + block->byte++; + block->data[block->byte] = 0; + } + return 0; + } + + block->data[block->byte] |= (val >> (nbits -= block->bit+1)); + block->bit = 7; + block->byte++; + block->data[block->byte] = 0; + + mask = 1<<(nbits-1); + do { + if (val & mask) + block->data[block->byte] |= (1 << block->bit); + if (--block->bit == -1) { + block->bit = 7; + block->byte++; + block->data[block->byte] = 0; + } + mask >>= 1; + } while(--nbits); + + return 0; +} + +/* + * Returns the next 'size' bytes from a block, or NULL if insufficient + * data left.This is just a pointer into the block data and not an + * allocated object, so do not free the result. + */ +static char *cram_extract_block(cram_block *b, int size) { + char *cp = (char *)b->data + b->idx; + b->idx += size; + if (b->idx > b->uncomp_size) + return NULL; + + return cp; +} + +/* + * --------------------------------------------------------------------------- + * EXTERNAL + */ +int cram_external_decode_int(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, int *out_size) { + int i; + char *cp; + cram_block *b = NULL; + + /* Find the external block */ + if (slice->block_by_id) { + if (!(b = slice->block_by_id[c->external.content_id])) + return *out_size?-1:0; + } else { + for (i = 0; i < slice->hdr->num_blocks; i++) { + b = slice->block[i]; + if (b && b->content_type == EXTERNAL && + b->content_id == c->external.content_id) { + break; + } + } + if (i == slice->hdr->num_blocks || !b) + return -1; + } + + cp = (char *)b->data + b->idx; + // E_INT and E_LONG are guaranteed single item queries + b->idx += itf8_get(cp, (int32_t *)out); + *out_size = 1; + + return 0; +} + +int cram_external_decode_char(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, + int *out_size) { + int i; + char *cp; + cram_block *b = NULL; + + /* Find the external block */ + if (slice->block_by_id) { + if (!(b = slice->block_by_id[c->external.content_id])) + return *out_size?-1:0; + } else { + for (i = 0; i < slice->hdr->num_blocks; i++) { + b = slice->block[i]; + if (b && b->content_type == EXTERNAL && + b->content_id == c->external.content_id) { + break; + } + } + if (i == slice->hdr->num_blocks || !b) + return -1; + } + + cp = cram_extract_block(b, *out_size); + if (!cp) + return -1; + + memcpy(out, cp, *out_size); + return 0; +} + +static int cram_external_decode_block(cram_slice *slice, cram_codec *c, + cram_block *in, char *out_, + int *out_size) { + int i; + char *cp; + cram_block *b = NULL; + cram_block *out = (cram_block *)out_; + + /* Find the external block */ + if (slice->block_by_id) { + if (!(b = slice->block_by_id[c->external.content_id])) + return *out_size?-1:0; + } else { + for (i = 0; i < slice->hdr->num_blocks; i++) { + b = slice->block[i]; + if (b && b->content_type == EXTERNAL && + b->content_id == c->external.content_id) { + break; + } + } + if (i == slice->hdr->num_blocks || !b) + return -1; + } + + cp = cram_extract_block(b, *out_size); + if (!cp) + return -1; + + BLOCK_APPEND(out, cp, *out_size); + return 0; +} + +void cram_external_decode_free(cram_codec *c) { + if (c) + free(c); +} + +cram_codec *cram_external_decode_init(char *data, int size, + enum cram_external_type option, + int version) { + cram_codec *c; + char *cp = data; + + if (!(c = malloc(sizeof(*c)))) + return NULL; + + c->codec = E_EXTERNAL; + if (option == E_INT || option == E_LONG) + c->decode = cram_external_decode_int; + else if (option == E_BYTE_ARRAY || option == E_BYTE) + c->decode = cram_external_decode_char; + else + c->decode = cram_external_decode_block; + c->free = cram_external_decode_free; + + cp += itf8_get(cp, &c->external.content_id); + + if (cp - data != size) { + fprintf(stderr, "Malformed external header stream\n"); + free(c); + return NULL; + } + + c->external.type = option; + + return c; +} + +int cram_external_encode_int(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + uint32_t *i32 = (uint32_t *)in; + + itf8_put_blk(c->out, *i32); + return 0; +} + +int cram_external_encode_char(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + BLOCK_APPEND(c->out, in, in_size); + return 0; +} + +void cram_external_encode_free(cram_codec *c) { + if (!c) + return; + free(c); +} + +int cram_external_encode_store(cram_codec *c, cram_block *b, char *prefix, + int version) { + char tmp[99], *tp = tmp; + int len = 0; + + if (prefix) { + size_t l = strlen(prefix); + BLOCK_APPEND(b, prefix, l); + len += l; + } + + tp += itf8_put(tp, c->e_external.content_id); + len += itf8_put_blk(b, c->codec); + len += itf8_put_blk(b, tp-tmp); + BLOCK_APPEND(b, tmp, tp-tmp); + len += tp-tmp; + + return len; +} + +cram_codec *cram_external_encode_init(cram_stats *st, + enum cram_external_type option, + void *dat, + int version) { + cram_codec *c; + + c = malloc(sizeof(*c)); + if (!c) + return NULL; + c->codec = E_EXTERNAL; + c->free = cram_external_encode_free; + if (option == E_INT || option == E_LONG) + c->encode = cram_external_encode_int; + else if (option == E_BYTE_ARRAY || option == E_BYTE) + c->encode = cram_external_encode_char; + else + abort(); + c->store = cram_external_encode_store; + + c->e_external.content_id = (size_t)dat; + + return c; +} + +/* + * --------------------------------------------------------------------------- + * BETA + */ +int cram_beta_decode_int(cram_slice *slice, cram_codec *c, cram_block *in, char *out, int *out_size) { + int32_t *out_i = (int32_t *)out; + int i, n; + + if (c->beta.nbits) { + for (i = 0, n = *out_size; i < n; i++) + out_i[i] = get_bits_MSB(in, c->beta.nbits) - c->beta.offset; + } else { + for (i = 0, n = *out_size; i < n; i++) + out_i[i] = -c->beta.offset; + } + + return 0; +} + +int cram_beta_decode_char(cram_slice *slice, cram_codec *c, cram_block *in, char *out, int *out_size) { + int i, n; + + if (c->beta.nbits) { + for (i = 0, n = *out_size; i < n; i++) + out[i] = get_bits_MSB(in, c->beta.nbits) - c->beta.offset; + } else { + for (i = 0, n = *out_size; i < n; i++) + out[i] = -c->beta.offset; + } + + return 0; +} + +void cram_beta_decode_free(cram_codec *c) { + if (c) + free(c); +} + +cram_codec *cram_beta_decode_init(char *data, int size, + enum cram_external_type option, + int version) { + cram_codec *c; + char *cp = data; + + if (!(c = malloc(sizeof(*c)))) + return NULL; + + c->codec = E_BETA; + if (option == E_INT || option == E_LONG) + c->decode = cram_beta_decode_int; + else if (option == E_BYTE_ARRAY || option == E_BYTE) + c->decode = cram_beta_decode_char; + else + abort(); + c->free = cram_beta_decode_free; + + cp += itf8_get(cp, &c->beta.offset); + cp += itf8_get(cp, &c->beta.nbits); + + if (cp - data != size) { + fprintf(stderr, "Malformed beta header stream\n"); + free(c); + return NULL; + } + + return c; +} + +int cram_beta_encode_store(cram_codec *c, cram_block *b, + char *prefix, int version) { + int len = 0; + + if (prefix) { + size_t l = strlen(prefix); + BLOCK_APPEND(b, prefix, l); + len += l; + } + + len += itf8_put_blk(b, c->codec); + len += itf8_put_blk(b, itf8_size(c->e_beta.offset) + + itf8_size(c->e_beta.nbits)); // codec length + len += itf8_put_blk(b, c->e_beta.offset); + len += itf8_put_blk(b, c->e_beta.nbits); + + return len; +} + +int cram_beta_encode_int(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + int *syms = (int *)in; + int i, r = 0; + + for (i = 0; i < in_size; i++) + r |= store_bits_MSB(c->out, syms[i] + c->e_beta.offset, + c->e_beta.nbits); + + return r; +} + +int cram_beta_encode_char(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + unsigned char *syms = (unsigned char *)in; + int i, r = 0; + + for (i = 0; i < in_size; i++) + r |= store_bits_MSB(c->out, syms[i] + c->e_beta.offset, + c->e_beta.nbits); + + return r; +} + +void cram_beta_encode_free(cram_codec *c) { + if (c) free(c); +} + +cram_codec *cram_beta_encode_init(cram_stats *st, + enum cram_external_type option, + void *dat, + int version) { + cram_codec *c; + int min_val, max_val, len = 0; + + c = malloc(sizeof(*c)); + if (!c) + return NULL; + c->codec = E_BETA; + c->free = cram_beta_encode_free; + if (option == E_INT) + c->encode = cram_beta_encode_int; + else + c->encode = cram_beta_encode_char; + c->store = cram_beta_encode_store; + + if (dat) { + min_val = ((int *)dat)[0]; + max_val = ((int *)dat)[1]; + } else { + min_val = INT_MAX; + max_val = INT_MIN; + int i; + for (i = 0; i < MAX_STAT_VAL; i++) { + if (!st->freqs[i]) + continue; + if (min_val > i) + min_val = i; + max_val = i; + } + if (st->h) { + khint_t k; + + for (k = kh_begin(st->h); k != kh_end(st->h); k++) { + if (!kh_exist(st->h, k)) + continue; + + i = kh_key(st->h, k); + if (min_val > i) + min_val = i; + if (max_val < i) + max_val = i; + } + } + } + + assert(max_val >= min_val); + c->e_beta.offset = -min_val; + max_val -= min_val; + while (max_val) { + len++; + max_val >>= 1; + } + c->e_beta.nbits = len; + + return c; +} + +/* + * --------------------------------------------------------------------------- + * SUBEXP + */ +int cram_subexp_decode(cram_slice *slice, cram_codec *c, cram_block *in, char *out, int *out_size) { + int32_t *out_i = (int32_t *)out; + int n, count; + int k = c->subexp.k; + + for (count = 0, n = *out_size; count < n; count++) { + int i = 0, tail; + int val; + + /* Get number of 1s */ + //while (get_bit_MSB(in) == 1) i++; + i = get_one_bits_MSB(in); + + /* + * Val is + * i > 0: 2^(k+i-1) + k+i-1 bits + * i = 0: k bits + */ + if (i) { + tail = i + k-1; + val = 0; + while (tail) { + //val = val<<1; val |= get_bit_MSB(in); + GET_BIT_MSB(in, val); + tail--; + } + val += 1 << (i + k-1); + } else { + tail = k; + val = 0; + while (tail) { + //val = val<<1; val |= get_bit_MSB(in); + GET_BIT_MSB(in, val); + tail--; + } + } + + out_i[count] = val - c->subexp.offset; + } + + return 0; +} + +void cram_subexp_decode_free(cram_codec *c) { + if (c) + free(c); +} + +cram_codec *cram_subexp_decode_init(char *data, int size, + enum cram_external_type option, + int version) { + cram_codec *c; + char *cp = data; + + if (!(c = malloc(sizeof(*c)))) + return NULL; + + c->codec = E_SUBEXP; + c->decode = cram_subexp_decode; + c->free = cram_subexp_decode_free; + + cp += itf8_get(cp, &c->subexp.offset); + cp += itf8_get(cp, &c->subexp.k); + + if (cp - data != size) { + fprintf(stderr, "Malformed subexp header stream\n"); + free(c); + return NULL; + } + + return c; +} + +/* + * --------------------------------------------------------------------------- + * GAMMA + */ +int cram_gamma_decode(cram_slice *slice, cram_codec *c, cram_block *in, char *out, int *out_size) { + int32_t *out_i = (int32_t *)out; + int i, n; + + for (i = 0, n = *out_size; i < n; i++) { + int nz = 0; + int val; + //while (get_bit_MSB(in) == 0) nz++; + nz = get_zero_bits_MSB(in); + val = 1; + while (nz > 0) { + //val <<= 1; val |= get_bit_MSB(in); + GET_BIT_MSB(in, val); + nz--; + } + + out_i[i] = val - c->gamma.offset; + } + + return 0; +} + +void cram_gamma_decode_free(cram_codec *c) { + if (c) + free(c); +} + +cram_codec *cram_gamma_decode_init(char *data, int size, + enum cram_external_type option, + int version) { + cram_codec *c; + char *cp = data; + + if (!(c = malloc(sizeof(*c)))) + return NULL; + + c->codec = E_GAMMA; + c->decode = cram_gamma_decode; + c->free = cram_gamma_decode_free; + + cp += itf8_get(cp, &c->gamma.offset); + + if (cp - data != size) { + fprintf(stderr, "Malformed gamma header stream\n"); + free(c); + return NULL; + } + + return c; +} + +/* + * --------------------------------------------------------------------------- + * HUFFMAN + */ + +static int code_sort(const void *vp1, const void *vp2) { + const cram_huffman_code *c1 = (const cram_huffman_code *)vp1; + const cram_huffman_code *c2 = (const cram_huffman_code *)vp2; + + if (c1->len != c2->len) + return c1->len - c2->len; + else + return c1->symbol - c2->symbol; +} + +void cram_huffman_decode_free(cram_codec *c) { + if (!c) + return; + + if (c->huffman.codes) + free(c->huffman.codes); + free(c); +} + +int cram_huffman_decode_char0(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, int *out_size) { + int i, n; + + /* Special case of 0 length codes */ + for (i = 0, n = *out_size; i < n; i++) { + out[i] = c->huffman.codes[0].symbol; + } + return 0; +} + +int cram_huffman_decode_char(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, int *out_size) { + int i, n, ncodes = c->huffman.ncodes; + const cram_huffman_code * const codes = c->huffman.codes; + + for (i = 0, n = *out_size; i < n; i++) { + int idx = 0; + int val = 0, len = 0, last_len = 0; + + for (;;) { + int dlen = codes[idx].len - last_len; + if (dlen <= 0 || (in->alloc - in->byte)*8 + in->bit + 7 < dlen) + return -1; + + //val <<= dlen; + //val |= get_bits_MSB(in, dlen); + //last_len = (len += dlen); + + last_len = (len += dlen); + for (; dlen; dlen--) GET_BIT_MSB(in, val); + + idx = val - codes[idx].p; + if (idx >= ncodes || idx < 0) + return -1; + + if (codes[idx].code == val && codes[idx].len == len) { + out[i] = codes[idx].symbol; + break; + } + } + } + + return 0; +} + +int cram_huffman_decode_int0(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, int *out_size) { + int32_t *out_i = (int32_t *)out; + int i, n; + const cram_huffman_code * const codes = c->huffman.codes; + + /* Special case of 0 length codes */ + for (i = 0, n = *out_size; i < n; i++) { + out_i[i] = codes[0].symbol; + } + return 0; +} + +int cram_huffman_decode_int(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, int *out_size) { + int32_t *out_i = (int32_t *)out; + int i, n, ncodes = c->huffman.ncodes; + const cram_huffman_code * const codes = c->huffman.codes; + + for (i = 0, n = *out_size; i < n; i++) { + int idx = 0; + int val = 0, len = 0, last_len = 0; + + // Now one bit at a time for remaining checks + for (;;) { + int dlen = codes[idx].len - last_len; + if (dlen <= 0 || (in->alloc - in->byte)*8 + in->bit + 7 < dlen) + return -1; + + //val <<= dlen; + //val |= get_bits_MSB(in, dlen); + //last_len = (len += dlen); + + last_len = (len += dlen); + for (; dlen; dlen--) GET_BIT_MSB(in, val); + + idx = val - codes[idx].p; + if (idx >= ncodes || idx < 0) + return -1; + + if (codes[idx].code == val && codes[idx].len == len) { + out_i[i] = codes[idx].symbol; + break; + } + } + } + + return 0; +} + +/* + * Initialises a huffman decoder from an encoding data stream. + */ +cram_codec *cram_huffman_decode_init(char *data, int size, + enum cram_external_type option, + int version) { + int32_t ncodes, i, j; + char *cp = data, *data_end = &data[size]; + cram_codec *h; + cram_huffman_code *codes; + int32_t val, last_len, max_len = 0; + + cp += itf8_get(cp, &ncodes); + h = calloc(1, sizeof(*h)); + if (!h) + return NULL; + + h->free = cram_huffman_decode_free; + + h->huffman.ncodes = ncodes; + codes = h->huffman.codes = malloc(ncodes * sizeof(*codes)); + if (!codes) { + free(h); + return NULL; + } + + /* Read symbols and bit-lengths */ + for (i = 0; i < ncodes && cp < data_end; i++) { + cp += itf8_get(cp, &codes[i].symbol); + } + + if (cp >= data_end) { + fprintf(stderr, "Malformed huffman header stream\n"); + free(h); + return NULL; + } + cp += itf8_get(cp, &i); + if (i != ncodes) { + fprintf(stderr, "Malformed huffman header stream\n"); + free(h); + return NULL; + } + + if (ncodes == 0) { + /* NULL huffman stream */ + return h; + } + + for (i = 0; i < ncodes && cp < data_end; i++) { + cp += itf8_get(cp, &codes[i].len); + if (max_len < codes[i].len) + max_len = codes[i].len; + } + if (cp - data != size || max_len >= ncodes) { + fprintf(stderr, "Malformed huffman header stream\n"); + free(h); + return NULL; + } + + /* Sort by bit length and then by symbol value */ + qsort(codes, ncodes, sizeof(*codes), code_sort); + + /* Assign canonical codes */ + val = -1, last_len = 0; + for (i = 0; i < ncodes; i++) { + val++; + if (codes[i].len > last_len) { + while (codes[i].len > last_len) { + val <<= 1; + last_len++; + } + } + codes[i].code = val; + } + + /* + * Compute the next starting point, offset by the i'th value. + * For example if codes 10, 11, 12, 13 are 30, 31, 32, 33 then + * codes[10..13].p = 30 - 10. + */ + last_len = 0; + for (i = j = 0; i < ncodes; i++) { + if (codes[i].len > last_len) { + j = codes[i].code - i; + last_len = codes[i].len; + } + codes[i].p = j; + } + +// puts("==HUFF LEN=="); +// for (i = 0; i <= last_len+1; i++) { +// printf("len %d=%d prefix %d\n", i, h->huffman.lengths[i], h->huffman.prefix[i]); +// } +// puts("===HUFFMAN CODES==="); +// for (i = 0; i < ncodes; i++) { +// int j; +// printf("%d: %d %d %d ", i, codes[i].symbol, codes[i].len, codes[i].code); +// j = codes[i].len; +// while (j) { +// putchar(codes[i].code & (1 << --j) ? '1' : '0'); +// } +// printf(" %d\n", codes[i].code); +// } + + h->codec = E_HUFFMAN; + if (option == E_BYTE || option == E_BYTE_ARRAY) { + if (h->huffman.codes[0].len == 0) + h->decode = cram_huffman_decode_char0; + else + h->decode = cram_huffman_decode_char; + } else if (option == E_BYTE_ARRAY_BLOCK) { + abort(); + } else { + if (h->huffman.codes[0].len == 0) + h->decode = cram_huffman_decode_int0; + else + h->decode = cram_huffman_decode_int; + } + + return (cram_codec *)h; +} + +int cram_huffman_encode_char0(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + return 0; +} + +int cram_huffman_encode_char(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + int i, code, len, r = 0; + unsigned char *syms = (unsigned char *)in; + + do { + int sym = *syms++; + if (sym >= -1 && sym < MAX_HUFF) { + i = c->e_huffman.val2code[sym+1]; + assert(c->e_huffman.codes[i].symbol == sym); + code = c->e_huffman.codes[i].code; + len = c->e_huffman.codes[i].len; + } else { + /* Slow - use a lookup table for when sym < MAX_HUFF? */ + for (i = 0; i < c->e_huffman.nvals; i++) { + if (c->e_huffman.codes[i].symbol == sym) + break; + } + if (i == c->e_huffman.nvals) + return -1; + + code = c->e_huffman.codes[i].code; + len = c->e_huffman.codes[i].len; + } + + r |= store_bits_MSB(c->out, code, len); + } while (--in_size); + + return r; +} + +int cram_huffman_encode_int0(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + return 0; +} + +int cram_huffman_encode_int(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + int i, code, len, r = 0; + int *syms = (int *)in; + + do { + int sym = *syms++; + + if (sym >= -1 && sym < MAX_HUFF) { + i = c->e_huffman.val2code[sym+1]; + assert(c->e_huffman.codes[i].symbol == sym); + code = c->e_huffman.codes[i].code; + len = c->e_huffman.codes[i].len; + } else { + /* Slow - use a lookup table for when sym < MAX_HUFFMAN_SYM? */ + for (i = 0; i < c->e_huffman.nvals; i++) { + if (c->e_huffman.codes[i].symbol == sym) + break; + } + if (i == c->e_huffman.nvals) + return -1; + + code = c->e_huffman.codes[i].code; + len = c->e_huffman.codes[i].len; + } + + r |= store_bits_MSB(c->out, code, len); + } while (--in_size); + + return r; +} + +void cram_huffman_encode_free(cram_codec *c) { + if (!c) + return; + + if (c->e_huffman.codes) + free(c->e_huffman.codes); + free(c); +} + +/* + * Encodes a huffman tree. + * Returns number of bytes written. + */ +int cram_huffman_encode_store(cram_codec *c, cram_block *b, char *prefix, + int version) { + int i, len = 0; + cram_huffman_code *codes = c->e_huffman.codes; + /* + * Up to code length 127 means 2.5e+26 bytes of data required (worst + * case huffman tree needs symbols with freqs matching the Fibonacci + * series). So guaranteed 1 byte per code. + * + * Symbols themselves could be 5 bytes (eg -1 is 5 bytes in itf8). + * + * Therefore 6*ncodes + 5 + 5 + 1 + 5 is max memory + */ + char *tmp = malloc(6*c->e_huffman.nvals+16); + char *tp = tmp; + + if (!tmp) + return -1; + + if (prefix) { + size_t l = strlen(prefix); + BLOCK_APPEND(b, prefix, l); + len += l; + } + + tp += itf8_put(tp, c->e_huffman.nvals); + for (i = 0; i < c->e_huffman.nvals; i++) { + tp += itf8_put(tp, codes[i].symbol); + } + + tp += itf8_put(tp, c->e_huffman.nvals); + for (i = 0; i < c->e_huffman.nvals; i++) { + tp += itf8_put(tp, codes[i].len); + } + + len += itf8_put_blk(b, c->codec); + len += itf8_put_blk(b, tp-tmp); + BLOCK_APPEND(b, tmp, tp-tmp); + len += tp-tmp; + + free(tmp); + + return len; +} + +cram_codec *cram_huffman_encode_init(cram_stats *st, + enum cram_external_type option, + void *dat, + int version) { + int *vals = NULL, *freqs = NULL, vals_alloc = 0, *lens, code, len; + int nvals, i, ntot = 0, max_val = 0, min_val = INT_MAX, k; + cram_codec *c; + cram_huffman_code *codes; + + c = malloc(sizeof(*c)); + if (!c) + return NULL; + c->codec = E_HUFFMAN; + + /* Count number of unique symbols */ + for (nvals = i = 0; i < MAX_STAT_VAL; i++) { + if (!st->freqs[i]) + continue; + if (nvals >= vals_alloc) { + vals_alloc = vals_alloc ? vals_alloc*2 : 1024; + vals = realloc(vals, vals_alloc * sizeof(int)); + freqs = realloc(freqs, vals_alloc * sizeof(int)); + if (!vals || !freqs) { + if (vals) free(vals); + if (freqs) free(freqs); + free(c); + return NULL; + } + } + vals[nvals] = i; + freqs[nvals] = st->freqs[i]; + assert(st->freqs[i] > 0); + ntot += freqs[nvals]; + if (max_val < i) max_val = i; + if (min_val > i) min_val = i; + nvals++; + } + if (st->h) { + khint_t k; + + for (k = kh_begin(st->h); k != kh_end(st->h); k++) { + if (!kh_exist(st->h, k)) + continue; + if (nvals >= vals_alloc) { + vals_alloc = vals_alloc ? vals_alloc*2 : 1024; + vals = realloc(vals, vals_alloc * sizeof(int)); + freqs = realloc(freqs, vals_alloc * sizeof(int)); + if (!vals || !freqs) + return NULL; + } + vals[nvals]= kh_key(st->h, k); + freqs[nvals] = kh_val(st->h, k); + assert(freqs[nvals] > 0); + ntot += freqs[nvals]; + if (max_val < i) max_val = i; + if (min_val > i) min_val = i; + nvals++; + } + } + + assert(nvals > 0); + + freqs = realloc(freqs, 2*nvals*sizeof(*freqs)); + lens = calloc(2*nvals, sizeof(*lens)); + if (!lens || !freqs) + return NULL; + + /* Inefficient, use pointers to form chain so we can insert and maintain + * a sorted list? This is currently O(nvals^2) complexity. + */ + for (;;) { + int low1 = INT_MAX, low2 = INT_MAX; + int ind1 = 0, ind2 = 0; + for (i = 0; i < nvals; i++) { + if (freqs[i] < 0) + continue; + if (low1 > freqs[i]) + low2 = low1, ind2 = ind1, low1 = freqs[i], ind1 = i; + else if (low2 > freqs[i]) + low2 = freqs[i], ind2 = i; + } + if (low2 == INT_MAX) + break; + + freqs[nvals] = low1 + low2; + lens[ind1] = nvals; + lens[ind2] = nvals; + freqs[ind1] *= -1; + freqs[ind2] *= -1; + nvals++; + } + nvals = nvals/2+1; + + /* Assign lengths */ + for (i = 0; i < nvals; i++) { + int code_len = 0; + for (k = lens[i]; k; k = lens[k]) + code_len++; + lens[i] = code_len; + freqs[i] *= -1; + //fprintf(stderr, "%d / %d => %d\n", vals[i], freqs[i], lens[i]); + } + + + /* Sort, need in a struct */ + if (!(codes = malloc(nvals * sizeof(*codes)))) + return NULL; + for (i = 0; i < nvals; i++) { + codes[i].symbol = vals[i]; + codes[i].len = lens[i]; + } + qsort(codes, nvals, sizeof(*codes), code_sort); + + /* + * Generate canonical codes from lengths. + * Sort by length. + * Start with 0. + * Every new code of same length is +1. + * Every new code of new length is +1 then <<1 per extra length. + * + * /\ + * a/\ + * /\/\ + * bcd/\ + * ef + * + * a 1 0 + * b 3 4 (0+1)<<2 + * c 3 5 + * d 3 6 + * e 4 14 (6+1)<<1 + * f 5 15 + */ + code = 0; len = codes[0].len; + for (i = 0; i < nvals; i++) { + while (len != codes[i].len) { + code<<=1; + len++; + } + codes[i].code = code++; + + if (codes[i].symbol >= -1 && codes[i].symbol < MAX_HUFF) + c->e_huffman.val2code[codes[i].symbol+1] = i; + + //fprintf(stderr, "sym %d, code %d, len %d\n", + // codes[i].symbol, codes[i].code, codes[i].len); + } + + free(lens); + free(vals); + free(freqs); + + c->e_huffman.codes = codes; + c->e_huffman.nvals = nvals; + + c->free = cram_huffman_encode_free; + if (option == E_BYTE || option == E_BYTE_ARRAY) { + if (c->e_huffman.codes[0].len == 0) + c->encode = cram_huffman_encode_char0; + else + c->encode = cram_huffman_encode_char; + } else { + if (c->e_huffman.codes[0].len == 0) + c->encode = cram_huffman_encode_int0; + else + c->encode = cram_huffman_encode_int; + } + c->store = cram_huffman_encode_store; + + return c; +} + +/* + * --------------------------------------------------------------------------- + * BYTE_ARRAY_LEN + */ +int cram_byte_array_len_decode(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, + int *out_size) { + /* Fetch length */ + int32_t len, one = 1; + + c->byte_array_len.len_codec->decode(slice, c->byte_array_len.len_codec, in, (char *)&len, &one); + //printf("ByteArray Len=%d\n", len); + + if (c->byte_array_len.value_codec) { + c->byte_array_len.value_codec->decode(slice, + c->byte_array_len.value_codec, + in, out, &len); + } else { + return -1; + } + + *out_size = len; + + return 0; +} + +void cram_byte_array_len_decode_free(cram_codec *c) { + if (!c) return; + + if (c->byte_array_len.len_codec) + c->byte_array_len.len_codec->free(c->byte_array_len.len_codec); + + if (c->byte_array_len.value_codec) + c->byte_array_len.value_codec->free(c->byte_array_len.value_codec); + + free(c); +} + +cram_codec *cram_byte_array_len_decode_init(char *data, int size, + enum cram_external_type option, + int version) { + cram_codec *c; + char *cp = data; + int32_t encoding; + int32_t sub_size; + + if (!(c = malloc(sizeof(*c)))) + return NULL; + + c->codec = E_BYTE_ARRAY_LEN; + c->decode = cram_byte_array_len_decode; + c->free = cram_byte_array_len_decode_free; + + cp += itf8_get(cp, &encoding); + cp += itf8_get(cp, &sub_size); + c->byte_array_len.len_codec = cram_decoder_init(encoding, cp, sub_size, + E_INT, version); + cp += sub_size; + + cp += itf8_get(cp, &encoding); + cp += itf8_get(cp, &sub_size); + c->byte_array_len.value_codec = cram_decoder_init(encoding, cp, sub_size, + option, version); + cp += sub_size; + + if (cp - data != size) { + fprintf(stderr, "Malformed byte_array_len header stream\n"); + free(c); + return NULL; + } + + return c; +} + +int cram_byte_array_len_encode(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + int32_t i32 = in_size; + int r = 0; + + r |= c->e_byte_array_len.len_codec->encode(slice, + c->e_byte_array_len.len_codec, + (char *)&i32, 1); + r |= c->e_byte_array_len.val_codec->encode(slice, + c->e_byte_array_len.val_codec, + in, in_size); + return r; +} + +void cram_byte_array_len_encode_free(cram_codec *c) { + if (!c) + return; + + if (c->e_byte_array_len.len_codec) + c->e_byte_array_len.len_codec->free(c->e_byte_array_len.len_codec); + + if (c->e_byte_array_len.val_codec) + c->e_byte_array_len.val_codec->free(c->e_byte_array_len.val_codec); + + free(c); +} + +int cram_byte_array_len_encode_store(cram_codec *c, cram_block *b, + char *prefix, int version) { + int len = 0, len2, len3; + cram_codec *tc; + cram_block *b_len, *b_val; + + if (prefix) { + size_t l = strlen(prefix); + BLOCK_APPEND(b, prefix, l); + len += l; + } + + tc = c->e_byte_array_len.len_codec; + b_len = cram_new_block(0, 0); + len2 = tc->store(tc, b_len, NULL, version); + + tc = c->e_byte_array_len.val_codec; + b_val = cram_new_block(0, 0); + len3 = tc->store(tc, b_val, NULL, version); + + len += itf8_put_blk(b, c->codec); + len += itf8_put_blk(b, len2+len3); + BLOCK_APPEND(b, BLOCK_DATA(b_len), BLOCK_SIZE(b_len)); + BLOCK_APPEND(b, BLOCK_DATA(b_val), BLOCK_SIZE(b_val)); + + cram_free_block(b_len); + cram_free_block(b_val); + + return len + len2 + len3; +} + +cram_codec *cram_byte_array_len_encode_init(cram_stats *st, + enum cram_external_type option, + void *dat, + int version) { + cram_codec *c; + cram_byte_array_len_encoder *e = (cram_byte_array_len_encoder *)dat; + + c = malloc(sizeof(*c)); + if (!c) + return NULL; + c->codec = E_BYTE_ARRAY_LEN; + c->free = cram_byte_array_len_encode_free; + c->encode = cram_byte_array_len_encode; + c->store = cram_byte_array_len_encode_store; + + c->e_byte_array_len.len_codec = cram_encoder_init(e->len_encoding, + NULL, E_INT, + e->len_dat, + version); + c->e_byte_array_len.val_codec = cram_encoder_init(e->val_encoding, + NULL, E_BYTE_ARRAY, + e->val_dat, + version); + + return c; +} + +/* + * --------------------------------------------------------------------------- + * BYTE_ARRAY_STOP + */ +static int cram_byte_array_stop_decode_char(cram_slice *slice, cram_codec *c, + cram_block *in, char *out, + int *out_size) { + int i; + cram_block *b = NULL; + char *cp, ch; + + if (slice->block_by_id) { + if (!(b = slice->block_by_id[c->byte_array_stop.content_id])) + return *out_size?-1:0; + } else { + for (i = 0; i < slice->hdr->num_blocks; i++) { + b = slice->block[i]; + if (b && b->content_type == EXTERNAL && + b->content_id == c->byte_array_stop.content_id) { + break; + } + } + if (i == slice->hdr->num_blocks || !b) + return -1; + } + + if (b->idx >= b->uncomp_size) + return -1; + + cp = (char *)b->data + b->idx; + while ((ch = *cp) != (char)c->byte_array_stop.stop) { + if (cp - (char *)b->data >= b->uncomp_size) + return -1; + *out++ = ch; + cp++; + } + + *out_size = cp - (char *)(b->data + b->idx); + b->idx = cp - (char *)b->data + 1; + + return 0; +} + +int cram_byte_array_stop_decode_block(cram_slice *slice, cram_codec *c, + cram_block *in, char *out_, + int *out_size) { + cram_block *b = NULL; + cram_block *out = (cram_block *)out_; + char *cp, *out_cp, *cp_end; + char stop; + + if (slice->block_by_id) { + if (!(b = slice->block_by_id[c->byte_array_stop.content_id])) + return *out_size?-1:0; + } else { + int i; + for (i = 0; i < slice->hdr->num_blocks; i++) { + b = slice->block[i]; + if (b && b->content_type == EXTERNAL && + b->content_id == c->byte_array_stop.content_id) { + break; + } + } + if (i == slice->hdr->num_blocks || !b) + return -1; + } + + if (b->idx >= b->uncomp_size) + return -1; + cp = (char *)b->data + b->idx; + cp_end = (char *)b->data + b->uncomp_size; + out_cp = (char *)BLOCK_END(out); + + stop = c->byte_array_stop.stop; + if (cp_end - cp < out->alloc - out->byte) { + while (*cp != stop && cp != cp_end) + *out_cp++ = *cp++; + BLOCK_SIZE(out) = out_cp - (char *)BLOCK_DATA(out); + } else { + char *cp_start; + for (cp_start = cp; *cp != stop && cp != cp_end; cp++) + ; + BLOCK_APPEND(out, cp_start, cp - cp_start); + BLOCK_GROW(out, cp - cp_start); + } + + *out_size = cp - (char *)(b->data + b->idx); + b->idx = cp - (char *)b->data + 1; + + return 0; +} + +void cram_byte_array_stop_decode_free(cram_codec *c) { + if (!c) return; + + free(c); +} + +cram_codec *cram_byte_array_stop_decode_init(char *data, int size, + enum cram_external_type option, + int version) { + cram_codec *c; + unsigned char *cp = (unsigned char *)data; + + if (!(c = malloc(sizeof(*c)))) + return NULL; + + c->codec = E_BYTE_ARRAY_STOP; + c->decode = (option == E_BYTE_ARRAY_BLOCK) + ? cram_byte_array_stop_decode_block + : cram_byte_array_stop_decode_char; + c->free = cram_byte_array_stop_decode_free; + + c->byte_array_stop.stop = *cp++; + if (CRAM_MAJOR_VERS(version) == 1) { + c->byte_array_stop.content_id = cp[0] + (cp[1]<<8) + (cp[2]<<16) + + (cp[3]<<24); + cp += 4; + } else { + cp += itf8_get(cp, &c->byte_array_stop.content_id); + } + + if ((char *)cp - data != size) { + fprintf(stderr, "Malformed byte_array_stop header stream\n"); + free(c); + return NULL; + } + + return c; +} + +int cram_byte_array_stop_encode(cram_slice *slice, cram_codec *c, + char *in, int in_size) { + BLOCK_APPEND(c->out, in, in_size); + BLOCK_APPEND_CHAR(c->out, c->e_byte_array_stop.stop); + return 0; +} + +void cram_byte_array_stop_encode_free(cram_codec *c) { + if (!c) + return; + free(c); +} + +int cram_byte_array_stop_encode_store(cram_codec *c, cram_block *b, + char *prefix, int version) { + int len = 0; + char buf[20], *cp = buf; + + if (prefix) { + size_t l = strlen(prefix); + BLOCK_APPEND(b, prefix, l); + len += l; + } + + cp += itf8_put(cp, c->codec); + + if (CRAM_MAJOR_VERS(version) == 1) { + cp += itf8_put(cp, 5); + *cp++ = c->e_byte_array_stop.stop; + *cp++ = (c->e_byte_array_stop.content_id >> 0) & 0xff; + *cp++ = (c->e_byte_array_stop.content_id >> 8) & 0xff; + *cp++ = (c->e_byte_array_stop.content_id >> 16) & 0xff; + *cp++ = (c->e_byte_array_stop.content_id >> 24) & 0xff; + } else { + cp += itf8_put(cp, 1 + itf8_size(c->e_byte_array_stop.content_id)); + *cp++ = c->e_byte_array_stop.stop; + cp += itf8_put(cp, c->e_byte_array_stop.content_id); + } + + BLOCK_APPEND(b, buf, cp-buf); + len += cp-buf; + + return len; +} + +cram_codec *cram_byte_array_stop_encode_init(cram_stats *st, + enum cram_external_type option, + void *dat, + int version) { + cram_codec *c; + + c = malloc(sizeof(*c)); + if (!c) + return NULL; + c->codec = E_BYTE_ARRAY_STOP; + c->free = cram_byte_array_stop_encode_free; + c->encode = cram_byte_array_stop_encode; + c->store = cram_byte_array_stop_encode_store; + + c->e_byte_array_stop.stop = ((int *)dat)[0]; + c->e_byte_array_stop.content_id = ((int *)dat)[1]; + + return c; +} + +/* + * --------------------------------------------------------------------------- + */ + +char *cram_encoding2str(enum cram_encoding t) { + switch (t) { + case E_NULL: return "NULL"; + case E_EXTERNAL: return "EXTERNAL"; + case E_GOLOMB: return "GOLOMB"; + case E_HUFFMAN: return "HUFFMAN"; + case E_BYTE_ARRAY_LEN: return "BYTE_ARRAY_LEN"; + case E_BYTE_ARRAY_STOP: return "BYTE_ARRAY_STOP"; + case E_BETA: return "BETA"; + case E_SUBEXP: return "SUBEXP"; + case E_GOLOMB_RICE: return "GOLOMB_RICE"; + case E_GAMMA: return "GAMMA"; + } + return "?"; +} + +static cram_codec *(*decode_init[])(char *data, + int size, + enum cram_external_type option, + int version) = { + NULL, + cram_external_decode_init, + NULL, + cram_huffman_decode_init, + cram_byte_array_len_decode_init, + cram_byte_array_stop_decode_init, + cram_beta_decode_init, + cram_subexp_decode_init, + NULL, + cram_gamma_decode_init, +}; + +cram_codec *cram_decoder_init(enum cram_encoding codec, + char *data, int size, + enum cram_external_type option, + int version) { + if (decode_init[codec]) { + return decode_init[codec](data, size, option, version); + } else { + fprintf(stderr, "Unimplemented codec of type %s\n", codec2str(codec)); + return NULL; + } +} + +static cram_codec *(*encode_init[])(cram_stats *stx, + enum cram_external_type option, + void *opt, + int version) = { + NULL, + cram_external_encode_init, + NULL, + cram_huffman_encode_init, + cram_byte_array_len_encode_init, + cram_byte_array_stop_encode_init, + cram_beta_encode_init, + NULL, //cram_subexp_encode_init, + NULL, + NULL, //cram_gamma_encode_init, +}; + +cram_codec *cram_encoder_init(enum cram_encoding codec, + cram_stats *st, + enum cram_external_type option, + void *dat, + int version) { + if (st && !st->nvals) + return NULL; + + if (encode_init[codec]) { + cram_codec *r; + if ((r = encode_init[codec](st, option, dat, version))) + r->out = NULL; + return r; + } else { + fprintf(stderr, "Unimplemented codec of type %s\n", codec2str(codec)); + abort(); + } +} + +/* + * Returns the content_id used by this codec, also in id2 if byte_array_len. + * Returns -1 for the CORE block and -2 for unneeded. + * id2 is only filled out for BYTE_ARRAY_LEN which uses 2 codecs. + */ +int cram_codec_to_id(cram_codec *c, int *id2) { + int bnum1, bnum2 = -2; + + switch (c->codec) { + case E_HUFFMAN: + bnum1 = c->huffman.ncodes == 1 ? -2 : -1; + break; + case E_GOLOMB: + case E_BETA: + case E_SUBEXP: + case E_GOLOMB_RICE: + case E_GAMMA: + bnum1 = -1; + break; + case E_EXTERNAL: + bnum1 = c->external.content_id; + break; + case E_BYTE_ARRAY_LEN: + bnum1 = cram_codec_to_id(c->byte_array_len.len_codec, NULL); + bnum2 = cram_codec_to_id(c->byte_array_len.value_codec, NULL); + break; + case E_BYTE_ARRAY_STOP: + bnum1 = c->byte_array_stop.content_id; + break; + case E_NULL: + bnum1 = -2; + break; + default: + fprintf(stderr, "Unknown codec type %d\n", c->codec); + bnum1 = -1; + } + + if (id2) + *id2 = bnum2; + return bnum1; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_codecs.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,165 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _CRAM_ENCODINGS_H_ +#define _CRAM_ENCODINGS_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +#include <inttypes.h> + +struct cram_codec; + +/* + * Slow but simple huffman decoder to start with. + * Read a bit at a time, keeping track of {length, value} + * eg. 1 1 0 1 => {1,1}, {2,3}, {3,6}, {4,13} + * + * Keep track of this through the huffman code table. + * For fast scanning we have an index of where the first code of length X + * appears. + */ +typedef struct { + int32_t symbol; + int32_t p; // next code start value, minus index to codes[] + int32_t code; + int32_t len; +} cram_huffman_code; + +typedef struct { + int ncodes; + cram_huffman_code *codes; +} cram_huffman_decoder; + +#define MAX_HUFF 128 +typedef struct { + cram_huffman_code *codes; + int nvals; + int val2code[MAX_HUFF+1]; // value to code lookup for small values +} cram_huffman_encoder; + +typedef struct { + int32_t offset; + int32_t nbits; +} cram_beta_decoder; + +typedef struct { + int32_t offset; +} cram_gamma_decoder; + +typedef struct { + int32_t offset; + int32_t k; +} cram_subexp_decoder; + +typedef struct { + int32_t content_id; + enum cram_external_type type; +} cram_external_decoder; + +typedef struct { + struct cram_codec *len_codec; + struct cram_codec *value_codec; +} cram_byte_array_len_decoder; + +typedef struct { + unsigned char stop; + int32_t content_id; +} cram_byte_array_stop_decoder; + +typedef struct { + enum cram_encoding len_encoding; + enum cram_encoding val_encoding; + void *len_dat; + void *val_dat; + struct cram_codec *len_codec; + struct cram_codec *val_codec; +} cram_byte_array_len_encoder; + +/* + * A generic codec structure. + */ +typedef struct cram_codec { + enum cram_encoding codec; + cram_block *out; + void (*free)(struct cram_codec *codec); + int (*decode)(cram_slice *slice, struct cram_codec *codec, + cram_block *in, char *out, int *out_size); + int (*encode)(cram_slice *slice, struct cram_codec *codec, + char *in, int in_size); + int (*store)(struct cram_codec *codec, cram_block *b, char *prefix, + int version); + union { + cram_huffman_decoder huffman; + cram_external_decoder external; + cram_beta_decoder beta; + cram_gamma_decoder gamma; + cram_subexp_decoder subexp; + cram_byte_array_len_decoder byte_array_len; + cram_byte_array_stop_decoder byte_array_stop; + + cram_huffman_encoder e_huffman; + cram_external_decoder e_external; + cram_byte_array_stop_decoder e_byte_array_stop; + cram_byte_array_len_encoder e_byte_array_len; + cram_beta_decoder e_beta; + }; +} cram_codec; + +char *cram_encoding2str(enum cram_encoding t); + +cram_codec *cram_decoder_init(enum cram_encoding codec, char *data, int size, + enum cram_external_type option, + int version); +cram_codec *cram_encoder_init(enum cram_encoding codec, cram_stats *st, + enum cram_external_type option, void *dat, + int version); + +//int cram_decode(void *codes, char *in, int in_size, char *out, int *out_size); +//void cram_decoder_free(void *codes); + +//#define GET_BIT_MSB(b,v) (void)(v<<=1, v|=(b->data[b->byte] >> b->bit)&1, (--b->bit == -1) && (b->bit = 7, b->byte++)) + +#define GET_BIT_MSB(b,v) (void)(v<<=1, v|=(b->data[b->byte] >> b->bit)&1, b->byte += (--b->bit<0), b->bit&=7) + +/* + * Returns the content_id used by this codec, also in id2 if byte_array_len. + * Returns -1 for the CORE block and -2 for unneeded. + * id2 is only filled out for BYTE_ARRAY_LEN which uses 2 codecs. + */ +int cram_codec_to_id(cram_codec *c, int *id2); + +#ifdef __cplusplus +} +#endif + +#endif /* _CRAM_ENCODINGS_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_decode.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,2775 @@ +/* +Copyright (c) 2012-2014 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* + * - In-memory decoding of CRAM data structures. + * - Iterator for reading CRAM record by record. + */ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdio.h> +#include <errno.h> +#include <assert.h> +#include <stdlib.h> +#include <string.h> +#include <zlib.h> +#include <sys/types.h> +#include <sys/stat.h> +#include <math.h> +#include <ctype.h> + +#include "cram/cram.h" +#include "cram/os.h" +#include "cram/md5.h" + +//Whether CIGAR has just M or uses = and X to indicate match and mismatch +//#define USE_X + +/* ---------------------------------------------------------------------- + * CRAM compression headers + */ + +/* + * Decodes the Tag Dictionary record in the preservation map + * Updates the cram compression header. + * + * Returns number of bytes decoded on success + * -1 on failure + */ +int cram_decode_TD(char *cp, cram_block_compression_hdr *h) { + char *op = cp; + unsigned char *dat; + cram_block *b; + int32_t blk_size; + int nTL, i, sz; + + if (!(b = cram_new_block(0, 0))) + return -1; + h->TD_blk = b; + + /* Decode */ + cp += itf8_get(cp, &blk_size); + if (!blk_size) { + h->nTL = 0; + h->TL = NULL; + cram_free_block(b); + return cp - op; + } + + BLOCK_APPEND(b, cp, blk_size); + cp += blk_size; + sz = cp - op; + + // Force nul termination if missing + if (BLOCK_DATA(b)[BLOCK_SIZE(b)-1]) + BLOCK_APPEND_CHAR(b, '\0'); + + /* Set up TL lookup table */ + dat = BLOCK_DATA(b); + + // Count + for (nTL = i = 0; i < BLOCK_SIZE(b); i++) { + nTL++; + while (dat[i]) + i++; + } + + // Copy + h->nTL = nTL; + if (!(h->TL = calloc(h->nTL, sizeof(unsigned char *)))) + return -1; + for (nTL = i = 0; i < BLOCK_SIZE(b); i++) { + h->TL[nTL++] = &dat[i]; + while (dat[i]) + i++; + } + + return sz; +} + +/* + * Decodes a CRAM block compression header. + * Returns header ptr on success + * NULL on failure + */ +cram_block_compression_hdr *cram_decode_compression_header(cram_fd *fd, + cram_block *b) { + char *cp, *cp_copy; + cram_block_compression_hdr *hdr = calloc(1, sizeof(*hdr)); + int i; + int32_t map_size, map_count; + + if (!hdr) + return NULL; + + if (b->method != RAW) { + if (cram_uncompress_block(b)) { + free(hdr); + return NULL; + } + } + + cp = (char *)b->data; + + if (CRAM_MAJOR_VERS(fd->version) == 1) { + cp += itf8_get(cp, &hdr->ref_seq_id); + cp += itf8_get(cp, &hdr->ref_seq_start); + cp += itf8_get(cp, &hdr->ref_seq_span); + cp += itf8_get(cp, &hdr->num_records); + cp += itf8_get(cp, &hdr->num_landmarks); + if (!(hdr->landmark = malloc(hdr->num_landmarks * sizeof(int32_t)))) { + free(hdr); + return NULL; + } + for (i = 0; i < hdr->num_landmarks; i++) { + cp += itf8_get(cp, &hdr->landmark[i]); + } + } + + hdr->preservation_map = kh_init(map); + + memset(hdr->rec_encoding_map, 0, + CRAM_MAP_HASH * sizeof(hdr->rec_encoding_map[0])); + memset(hdr->tag_encoding_map, 0, + CRAM_MAP_HASH * sizeof(hdr->tag_encoding_map[0])); + + if (!hdr->preservation_map) { + cram_free_compression_header(hdr); + return NULL; + } + + /* Initialise defaults for preservation map */ + hdr->mapped_qs_included = 0; + hdr->unmapped_qs_included = 0; + hdr->unmapped_placed = 0; + hdr->qs_included = 0; + hdr->read_names_included = 0; + hdr->AP_delta = 1; + memcpy(hdr->substitution_matrix, "CGTNAGTNACTNACGNACGT", 20); + + /* Preservation map */ + cp += itf8_get(cp, &map_size); cp_copy = cp; + cp += itf8_get(cp, &map_count); + for (i = 0; i < map_count; i++) { + pmap_t hd; + khint_t k; + int r; + + cp += 2; + switch(CRAM_KEY(cp[-2],cp[-1])) { + case CRAM_KEY('M','I'): + hd.i = *cp++; + k = kh_put(map, hdr->preservation_map, "MI", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + + kh_val(hdr->preservation_map, k) = hd; + hdr->mapped_qs_included = hd.i; + break; + + case CRAM_KEY('U','I'): + hd.i = *cp++; + k = kh_put(map, hdr->preservation_map, "UI", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + + kh_val(hdr->preservation_map, k) = hd; + hdr->unmapped_qs_included = hd.i; + break; + + case CRAM_KEY('P','I'): + hd.i = *cp++; + k = kh_put(map, hdr->preservation_map, "PI", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + + kh_val(hdr->preservation_map, k) = hd; + hdr->unmapped_placed = hd.i; + break; + + case CRAM_KEY('R','N'): + hd.i = *cp++; + k = kh_put(map, hdr->preservation_map, "RN", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + + kh_val(hdr->preservation_map, k) = hd; + hdr->read_names_included = hd.i; + break; + + case CRAM_KEY('A','P'): + hd.i = *cp++; + k = kh_put(map, hdr->preservation_map, "AP", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + + kh_val(hdr->preservation_map, k) = hd; + hdr->AP_delta = hd.i; + break; + + case CRAM_KEY('R','R'): + hd.i = *cp++; + k = kh_put(map, hdr->preservation_map, "RR", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + + kh_val(hdr->preservation_map, k) = hd; + fd->no_ref = !hd.i; + break; + + case CRAM_KEY('S','M'): + hdr->substitution_matrix[0][(cp[0]>>6)&3] = 'C'; + hdr->substitution_matrix[0][(cp[0]>>4)&3] = 'G'; + hdr->substitution_matrix[0][(cp[0]>>2)&3] = 'T'; + hdr->substitution_matrix[0][(cp[0]>>0)&3] = 'N'; + + hdr->substitution_matrix[1][(cp[1]>>6)&3] = 'A'; + hdr->substitution_matrix[1][(cp[1]>>4)&3] = 'G'; + hdr->substitution_matrix[1][(cp[1]>>2)&3] = 'T'; + hdr->substitution_matrix[1][(cp[1]>>0)&3] = 'N'; + + hdr->substitution_matrix[2][(cp[2]>>6)&3] = 'A'; + hdr->substitution_matrix[2][(cp[2]>>4)&3] = 'C'; + hdr->substitution_matrix[2][(cp[2]>>2)&3] = 'T'; + hdr->substitution_matrix[2][(cp[2]>>0)&3] = 'N'; + + hdr->substitution_matrix[3][(cp[3]>>6)&3] = 'A'; + hdr->substitution_matrix[3][(cp[3]>>4)&3] = 'C'; + hdr->substitution_matrix[3][(cp[3]>>2)&3] = 'G'; + hdr->substitution_matrix[3][(cp[3]>>0)&3] = 'N'; + + hdr->substitution_matrix[4][(cp[4]>>6)&3] = 'A'; + hdr->substitution_matrix[4][(cp[4]>>4)&3] = 'C'; + hdr->substitution_matrix[4][(cp[4]>>2)&3] = 'G'; + hdr->substitution_matrix[4][(cp[4]>>0)&3] = 'T'; + + hd.p = cp; + cp += 5; + + k = kh_put(map, hdr->preservation_map, "SM", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + kh_val(hdr->preservation_map, k) = hd; + break; + + case CRAM_KEY('T','D'): { + int sz = cram_decode_TD(cp, hdr); // tag dictionary + if (sz < 0) { + cram_free_compression_header(hdr); + return NULL; + } + + hd.p = cp; + cp += sz; + + k = kh_put(map, hdr->preservation_map, "TD", &r); + if (-1 == r) { + cram_free_compression_header(hdr); + return NULL; + } + kh_val(hdr->preservation_map, k) = hd; + break; + } + + default: + fprintf(stderr, "Unrecognised preservation map key %c%c\n", + cp[-2], cp[-1]); + // guess byte; + cp++; + break; + } + } + if (cp - cp_copy != map_size) { + cram_free_compression_header(hdr); + return NULL; + } + + /* Record encoding map */ + cp += itf8_get(cp, &map_size); cp_copy = cp; + cp += itf8_get(cp, &map_count); + for (i = 0; i < map_count; i++) { + char *key = cp; + int32_t encoding; + int32_t size; + cram_map *m = malloc(sizeof(*m)); // FIXME: use pooled_alloc + + if (!m) { + cram_free_compression_header(hdr); + return NULL; + } + + cp += 2; + cp += itf8_get(cp, &encoding); + cp += itf8_get(cp, &size); + + // Fill out cram_map purely for cram_dump to dump out. + m->key = (key[0]<<8)|key[1]; + m->encoding = encoding; + m->size = size; + m->offset = cp - (char *)b->data; + m->codec = NULL; + + if (m->encoding == E_NULL) + continue; + + //printf("%s codes for %.2s\n", cram_encoding2str(encoding), key); + + /* + * For CRAM1.0 CF and BF are Byte and not Int. + * Practically speaking it makes no difference unless we have a + * 1.0 format file that stores these in EXTERNAL as only then + * does Byte vs Int matter. + * + * Neither this C code nor Java reference implementations did this, + * so we gloss over it and treat them as int. + */ + + if (key[0] == 'B' && key[1] == 'F') { + if (!(hdr->codecs[DS_BF] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'C' && key[1] == 'F') { + if (!(hdr->codecs[DS_CF] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'R' && key[1] == 'I') { + if (!(hdr->codecs[DS_RI] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'R' && key[1] == 'L') { + if (!(hdr->codecs[DS_RL] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'A' && key[1] == 'P') { + if (!(hdr->codecs[DS_AP] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'R' && key[1] == 'G') { + if (!(hdr->codecs[DS_RG] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'M' && key[1] == 'F') { + if (!(hdr->codecs[DS_MF] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'N' && key[1] == 'S') { + if (!(hdr->codecs[DS_NS] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'N' && key[1] == 'P') { + if (!(hdr->codecs[DS_NP] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'T' && key[1] == 'S') { + if (!(hdr->codecs[DS_TS] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'N' && key[1] == 'F') { + if (!(hdr->codecs[DS_NF] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'T' && key[1] == 'C') { + if (!(hdr->codecs[DS_TC] = cram_decoder_init(encoding, cp, size, + E_BYTE, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'T' && key[1] == 'N') { + if (!(hdr->codecs[DS_TN] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'F' && key[1] == 'N') { + if (!(hdr->codecs[DS_FN] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'F' && key[1] == 'C') { + if (!(hdr->codecs[DS_FC] = cram_decoder_init(encoding, cp, size, + E_BYTE, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'F' && key[1] == 'P') { + if (!(hdr->codecs[DS_FP] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'B' && key[1] == 'S') { + if (!(hdr->codecs[DS_BS] = cram_decoder_init(encoding, cp, size, + E_BYTE, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'I' && key[1] == 'N') { + if (!(hdr->codecs[DS_IN] = cram_decoder_init(encoding, cp, size, + E_BYTE_ARRAY, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'S' && key[1] == 'C') { + if (!(hdr->codecs[DS_SC] = cram_decoder_init(encoding, cp, size, + E_BYTE_ARRAY, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'D' && key[1] == 'L') { + if (!(hdr->codecs[DS_DL] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'B' && key[1] == 'A') { + if (!(hdr->codecs[DS_BA] = cram_decoder_init(encoding, cp, size, + E_BYTE, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'B' && key[1] == 'B') { + if (!(hdr->codecs[DS_BB] = cram_decoder_init(encoding, cp, size, + E_BYTE_ARRAY, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'R' && key[1] == 'S') { + if (!(hdr->codecs[DS_RS] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'P' && key[1] == 'D') { + if (!(hdr->codecs[DS_PD] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'H' && key[1] == 'C') { + if (!(hdr->codecs[DS_HC] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'M' && key[1] == 'Q') { + if (!(hdr->codecs[DS_MQ] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'R' && key[1] == 'N') { + if (!(hdr->codecs[DS_RN] = cram_decoder_init(encoding, cp, size, + E_BYTE_ARRAY_BLOCK, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'Q' && key[1] == 'S') { + if (!(hdr->codecs[DS_QS] = cram_decoder_init(encoding, cp, size, + E_BYTE, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'Q' && key[1] == 'Q') { + if (!(hdr->codecs[DS_QQ] = cram_decoder_init(encoding, cp, size, + E_BYTE_ARRAY, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'T' && key[1] == 'L') { + if (!(hdr->codecs[DS_TL] = cram_decoder_init(encoding, cp, size, + E_INT, + fd->version))) { + cram_free_compression_header(hdr); + return NULL; + } + } else if (key[0] == 'T' && key[1] == 'M') { + } else if (key[0] == 'T' && key[1] == 'V') { + } else + fprintf(stderr, "Unrecognised key: %.2s\n", key); + + cp += size; + + m->next = hdr->rec_encoding_map[CRAM_MAP(key[0], key[1])]; + hdr->rec_encoding_map[CRAM_MAP(key[0], key[1])] = m; + } + if (cp - cp_copy != map_size) { + cram_free_compression_header(hdr); + return NULL; + } + + /* Tag encoding map */ + cp += itf8_get(cp, &map_size); cp_copy = cp; + cp += itf8_get(cp, &map_count); + for (i = 0; i < map_count; i++) { + int32_t encoding; + int32_t size; + cram_map *m = malloc(sizeof(*m)); // FIXME: use pooled_alloc + char *key = cp+1; + + if (!m) { + cram_free_compression_header(hdr); + return NULL; + } + + m->key = (key[0]<<16)|(key[1]<<8)|key[2]; + + cp += 4; // Strictly ITF8, but this suffices + cp += itf8_get(cp, &encoding); + cp += itf8_get(cp, &size); + + m->encoding = encoding; + m->size = size; + m->offset = cp - (char *)b->data; + if (!(m->codec = cram_decoder_init(encoding, cp, size, + E_BYTE_ARRAY_BLOCK, fd->version))) { + cram_free_compression_header(hdr); + free(m); + return NULL; + } + + cp += size; + + m->next = hdr->tag_encoding_map[CRAM_MAP(key[0],key[1])]; + hdr->tag_encoding_map[CRAM_MAP(key[0],key[1])] = m; + } + if (cp - cp_copy != map_size) { + cram_free_compression_header(hdr); + return NULL; + } + + return hdr; +} + +/* + * Note we also need to scan through the record encoding map to + * see which data series share the same block, either external or + * CORE. For example if we need the BF data series but MQ and CF + * are also encoded in the same block then we need to add those in + * as a dependency in order to correctly decode BF. + * + * Returns 0 on success + * -1 on failure + */ +int cram_dependent_data_series(cram_fd *fd, + cram_block_compression_hdr *hdr, + cram_slice *s) { + int *block_used; + int core_used = 0; + int i; + static int i_to_id[] = { + DS_BF, DS_AP, DS_FP, DS_RL, DS_DL, DS_NF, DS_BA, DS_QS, + DS_FC, DS_FN, DS_BS, DS_IN, DS_RG, DS_MQ, DS_TL, DS_RN, + DS_NS, DS_NP, DS_TS, DS_MF, DS_CF, DS_RI, DS_RS, DS_PD, + DS_HC, DS_SC, DS_BB, DS_QQ, + }; + uint32_t orig_ds; + + /* + * Set the data_series bit field based on fd->required_fields + * contents. + */ + if (fd->required_fields && fd->required_fields != INT_MAX) { + hdr->data_series = 0; + + if (fd->required_fields & SAM_QNAME) + hdr->data_series |= CRAM_RN; + + if (fd->required_fields & SAM_FLAG) + hdr->data_series |= CRAM_BF; + + if (fd->required_fields & SAM_RNAME) + hdr->data_series |= CRAM_RI | CRAM_BF; + + if (fd->required_fields & SAM_POS) + hdr->data_series |= CRAM_AP | CRAM_BF; + + if (fd->required_fields & SAM_MAPQ) + hdr->data_series |= CRAM_MQ; + + if (fd->required_fields & SAM_CIGAR) + hdr->data_series |= CRAM_CIGAR; + + if (fd->required_fields & SAM_RNEXT) + hdr->data_series |= CRAM_CF | CRAM_NF | CRAM_RI | CRAM_NS |CRAM_BF; + + if (fd->required_fields & SAM_PNEXT) + hdr->data_series |= CRAM_CF | CRAM_NF | CRAM_AP | CRAM_NP | CRAM_BF; + + if (fd->required_fields & SAM_TLEN) + hdr->data_series |= CRAM_CF | CRAM_NF | CRAM_AP | CRAM_TS | + CRAM_BF | CRAM_MF | CRAM_RI | CRAM_CIGAR; + + if (fd->required_fields & SAM_SEQ) + hdr->data_series |= CRAM_SEQ; + + if (!(fd->required_fields & SAM_AUX)) + // No easy way to get MD/NM without other tags at present + fd->decode_md = 0; + + if (fd->required_fields & SAM_QUAL) + hdr->data_series |= CRAM_SEQ; + + if (fd->required_fields & SAM_AUX) + hdr->data_series |= CRAM_RG | CRAM_TL | CRAM_aux; + + if (fd->required_fields & SAM_RGAUX) + hdr->data_series |= CRAM_RG | CRAM_BF; + + // Always uncompress CORE block + if (cram_uncompress_block(s->block[0])) + return -1; + } else { + hdr->data_series = CRAM_ALL; + + for (i = 0; i < s->hdr->num_blocks; i++) { + if (cram_uncompress_block(s->block[i])) + return -1; + } + + return 0; + } + + block_used = calloc(s->hdr->num_blocks+1, sizeof(int)); + if (!block_used) + return -1; + + do { + /* + * Also set data_series based on code prerequisites. Eg if we need + * CRAM_QS then we also need to know CRAM_RL so we know how long it + * is, or if we need FC/FP then we also need FN (number of features). + * + * It's not reciprocal though. We may be needing to decode FN + * but have no need to decode FC, FP and cigar ops. + */ + if (hdr->data_series & CRAM_RS) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_PD) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_HC) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_QS) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_IN) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_SC) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_BS) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_DL) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_BA) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_BB) hdr->data_series |= CRAM_FC|CRAM_FP; + if (hdr->data_series & CRAM_QQ) hdr->data_series |= CRAM_FC|CRAM_FP; + + // cram_decode_seq() needs seq[] array + if (hdr->data_series & (CRAM_SEQ|CRAM_CIGAR)) hdr->data_series |= CRAM_RL; + + if (hdr->data_series & CRAM_FP) hdr->data_series |= CRAM_FC; + if (hdr->data_series & CRAM_FC) hdr->data_series |= CRAM_FN; + if (hdr->data_series & CRAM_aux) hdr->data_series |= CRAM_TL; + if (hdr->data_series & CRAM_MF) hdr->data_series |= CRAM_CF; + if (hdr->data_series & CRAM_MQ) hdr->data_series |= CRAM_BF; + if (hdr->data_series & CRAM_BS) hdr->data_series |= CRAM_RI; + if (hdr->data_series & (CRAM_MF |CRAM_NS |CRAM_NP |CRAM_TS |CRAM_NF)) + hdr->data_series |= CRAM_CF; + if (!hdr->read_names_included && hdr->data_series & CRAM_RN) + hdr->data_series |= CRAM_CF | CRAM_NF; + if (hdr->data_series & (CRAM_BA | CRAM_QS | CRAM_BB | CRAM_QQ)) + hdr->data_series |= CRAM_BF | CRAM_CF | CRAM_RL; + + orig_ds = hdr->data_series; + + // Find which blocks are in use. + for (i = 0; i < sizeof(i_to_id)/sizeof(*i_to_id); i++) { + int bnum1, bnum2, j; + cram_codec *c = hdr->codecs[i_to_id[i]]; + + if (!(hdr->data_series & (1<<i))) + continue; + + if (!c) + continue; + + bnum1 = cram_codec_to_id(c, &bnum2); + + for (;;) { + switch (bnum1) { + case -2: + break; + + case -1: + core_used = 1; + break; + + default: + for (j = 0; j < s->hdr->num_blocks; j++) { + if (s->block[j]->content_type == EXTERNAL && + s->block[j]->content_id == bnum1) { + block_used[j] = 1; + if (cram_uncompress_block(s->block[j])) { + free(block_used); + return -1; + } + } + } + break; + } + + if (bnum2 == -2 || bnum1 == bnum2) + break; + + bnum1 = bnum2; // 2nd pass + } + } + + // Tags too + if ((fd->required_fields & SAM_AUX) || + (hdr->data_series & CRAM_aux)) { + for (i = 0; i < CRAM_MAP_HASH; i++) { + int bnum1, bnum2, j; + cram_map *m = hdr->tag_encoding_map[i]; + + while (m) { + cram_codec *c = m->codec; + if (!c) + continue; + + bnum1 = cram_codec_to_id(c, &bnum2); + + for (;;) { + switch (bnum1) { + case -2: + break; + + case -1: + core_used = 1; + break; + + default: + for (j = 0; j < s->hdr->num_blocks; j++) { + if (s->block[j]->content_type == EXTERNAL && + s->block[j]->content_id == bnum1) { + block_used[j] = 1; + if (cram_uncompress_block(s->block[j])) { + free(block_used); + return -1; + } + } + } + break; + } + + if (bnum2 == -2 || bnum1 == bnum2) + break; + + bnum1 = bnum2; // 2nd pass + } + + m = m->next; + } + } + } + + // We now know which blocks are in used, so repeat and find + // which other data series need to be added. + for (i = 0; i < sizeof(i_to_id)/sizeof(*i_to_id); i++) { + int bnum1, bnum2, j; + cram_codec *c = hdr->codecs[i_to_id[i]]; + + if (!c) + continue; + + bnum1 = cram_codec_to_id(c, &bnum2); + + for (;;) { + switch (bnum1) { + case -2: + break; + + case -1: + if (core_used) { + //printf(" + data series %08x:\n", 1<<i); + hdr->data_series |= 1<<i; + } + break; + + default: + for (j = 0; j < s->hdr->num_blocks; j++) { + if (s->block[j]->content_type == EXTERNAL && + s->block[j]->content_id == bnum1) { + if (block_used[j]) { + //printf(" + data series %08x:\n", 1<<i); + hdr->data_series |= 1<<i; + } + } + } + break; + } + + if (bnum2 == -2 || bnum1 == bnum2) + break; + + bnum1 = bnum2; // 2nd pass + } + } + + // Tags too + for (i = 0; i < CRAM_MAP_HASH; i++) { + int bnum1, bnum2, j; + cram_map *m = hdr->tag_encoding_map[i]; + + while (m) { + cram_codec *c = m->codec; + if (!c) + continue; + + bnum1 = cram_codec_to_id(c, &bnum2); + + for (;;) { + switch (bnum1) { + case -2: + break; + + case -1: + //printf(" + data series %08x:\n", CRAM_aux); + hdr->data_series |= CRAM_aux; + break; + + default: + for (j = 0; j < s->hdr->num_blocks; j++) { + if (s->block[j]->content_type && + s->block[j]->content_id == bnum1) { + if (block_used[j]) { + //printf(" + data series %08x:\n", + // CRAM_aux); + hdr->data_series |= CRAM_aux; + } + } + } + break; + } + + if (bnum2 == -2 || bnum1 == bnum2) + break; + + bnum1 = bnum2; // 2nd pass + } + + m = m->next; + } + } + } while (orig_ds != hdr->data_series); + + free(block_used); + return 0; +} + +/* ---------------------------------------------------------------------- + * CRAM slices + */ + +/* + * Decodes a CRAM (un)mapped slice header block. + * Returns slice header ptr on success + * NULL on failure + */ +cram_block_slice_hdr *cram_decode_slice_header(cram_fd *fd, cram_block *b) { + cram_block_slice_hdr *hdr; + char *cp = (char *)b->data; + int i; + + if (b->content_type != MAPPED_SLICE && + b->content_type != UNMAPPED_SLICE) + return NULL; + + if (!(hdr = calloc(1, sizeof(*hdr)))) + return NULL; + + hdr->content_type = b->content_type; + + if (b->content_type == MAPPED_SLICE) { + cp += itf8_get(cp, &hdr->ref_seq_id); + cp += itf8_get(cp, &hdr->ref_seq_start); + cp += itf8_get(cp, &hdr->ref_seq_span); + } + cp += itf8_get(cp, &hdr->num_records); + hdr->record_counter = 0; + if (CRAM_MAJOR_VERS(fd->version) == 2) { + int32_t i32; + cp += itf8_get(cp, &i32); + hdr->record_counter = i32; + } else if (CRAM_MAJOR_VERS(fd->version) >= 3) { + cp += ltf8_get(cp, &hdr->record_counter); + } + + cp += itf8_get(cp, &hdr->num_blocks); + + cp += itf8_get(cp, &hdr->num_content_ids); + hdr->block_content_ids = malloc(hdr->num_content_ids * sizeof(int32_t)); + if (!hdr->block_content_ids) { + free(hdr); + return NULL; + } + + for (i = 0; i < hdr->num_content_ids; i++) { + cp += itf8_get(cp, &hdr->block_content_ids[i]); + } + + if (b->content_type == MAPPED_SLICE) { + cp += itf8_get(cp, &hdr->ref_base_id); + } + + if (CRAM_MAJOR_VERS(fd->version) != 1) { + memcpy(hdr->md5, cp, 16); + } else { + memset(hdr->md5, 0, 16); + } + + return hdr; +} + + +#if 0 +/* Returns the number of bits set in val; it the highest bit used */ +static int nbits(int v) { + static const int MultiplyDeBruijnBitPosition[32] = { + 1, 10, 2, 11, 14, 22, 3, 30, 12, 15, 17, 19, 23, 26, 4, 31, + 9, 13, 21, 29, 16, 18, 25, 8, 20, 28, 24, 7, 27, 6, 5, 32 + }; + + v |= v >> 1; // first up to set all bits 1 after the first 1 */ + v |= v >> 2; + v |= v >> 4; + v |= v >> 8; + v |= v >> 16; + + // DeBruijn magic to find top bit + return MultiplyDeBruijnBitPosition[(uint32_t)(v * 0x07C4ACDDU) >> 27]; +} +#endif + +#if 0 +static int sort_freqs(const void *vp1, const void *vp2) { + const int i1 = *(const int *)vp1; + const int i2 = *(const int *)vp2; + return i1-i2; +} +#endif + +/* ---------------------------------------------------------------------- + * Primary CRAM sequence decoder + */ + +/* + * Internal part of cram_decode_slice(). + * Generates the sequence, quality and cigar components. + */ +static int cram_decode_seq(cram_fd *fd, cram_container *c, cram_slice *s, + cram_block *blk, cram_record *cr, SAM_hdr *bfd, + int cf, char *seq, char *qual) { + int prev_pos = 0, f, r = 0, out_sz = 1; + int seq_pos = 1; + int cig_len = 0, ref_pos = cr->apos; + int32_t fn, i32; + enum cigar_op cig_op = BAM_CMATCH; + uint32_t *cigar = s->cigar; + uint32_t ncigar = s->ncigar; + uint32_t cigar_alloc = s->cigar_alloc; + uint32_t nm = 0, md_dist = 0; + int orig_aux = 0; + int decode_md = fd->decode_md && s->ref; + uint32_t ds = c->comp_hdr->data_series; + + if ((ds & CRAM_QS) && !(cf & CRAM_FLAG_PRESERVE_QUAL_SCORES)) { + memset(qual, 30, cr->len); + } + + if (decode_md) { + orig_aux = BLOCK_SIZE(s->aux_blk); + BLOCK_APPEND(s->aux_blk, "MDZ", 3); + } + + if (ds & CRAM_FN) { + if (!c->comp_hdr->codecs[DS_FN]) return -1; + r |= c->comp_hdr->codecs[DS_FN]->decode(s,c->comp_hdr->codecs[DS_FN], + blk, (char *)&fn, &out_sz); + } else { + fn = 0; + } + + ref_pos--; // count from 0 + cr->cigar = ncigar; + + if (!(ds & (CRAM_FC | CRAM_FP))) + goto skip_cigar; + + for (f = 0; f < fn; f++) { + int32_t pos = 0; + char op; + + if (ncigar+2 >= cigar_alloc) { + cigar_alloc = cigar_alloc ? cigar_alloc*2 : 1024; + s->cigar = cigar; + if (!(cigar = realloc(cigar, cigar_alloc * sizeof(*cigar)))) + return -1; + } + + if (ds & CRAM_FC) { + if (!c->comp_hdr->codecs[DS_FC]) return -1; + r |= c->comp_hdr->codecs[DS_FC]->decode(s, + c->comp_hdr->codecs[DS_FC], + blk, + &op, &out_sz); + } + + if (!(ds & CRAM_FP)) + continue; + + if (!c->comp_hdr->codecs[DS_FP]) return -1; + r |= c->comp_hdr->codecs[DS_FP]->decode(s, + c->comp_hdr->codecs[DS_FP], + blk, + (char *)&pos, &out_sz); + pos += prev_pos; + + if (pos > seq_pos) { + if (pos > cr->len+1) + return -1; + + if (s->ref && cr->ref_id >= 0) { + if (ref_pos + pos - seq_pos > bfd->ref[cr->ref_id].len) { + static int whinged = 0; + if (!whinged) + fprintf(stderr, "Ref pos outside of ref " + "sequence boundary\n"); + whinged = 1; + } else { + memcpy(&seq[seq_pos-1], &s->ref[ref_pos - s->ref_start +1], + pos - seq_pos); + } + } +#ifdef USE_X + if (cig_len && cig_op != BAM_CBASE_MATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + cig_op = BAM_CBASE_MATCH; +#else + if (cig_len && cig_op != BAM_CMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + cig_op = BAM_CMATCH; +#endif + cig_len += pos - seq_pos; + ref_pos += pos - seq_pos; + md_dist += pos - seq_pos; + seq_pos = pos; + } + + prev_pos = pos; + + if (!(ds & CRAM_FC)) + goto skip_cigar; + + if (!(ds & CRAM_FC)) + continue; + + switch(op) { + case 'S': { // soft clip: IN + int32_t out_sz2 = 1; + + if (cig_len) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_IN) { + switch (CRAM_MAJOR_VERS(fd->version)) { + case 1: + r |= c->comp_hdr->codecs[DS_IN] + ? c->comp_hdr->codecs[DS_IN] + ->decode(s, c->comp_hdr->codecs[DS_IN], + blk, &seq[pos-1], &out_sz2) + : (seq[pos-1] = 'N', out_sz2 = 1, 0); + break; + + case 2: + default: + r |= c->comp_hdr->codecs[DS_SC] + ? c->comp_hdr->codecs[DS_SC] + ->decode(s, c->comp_hdr->codecs[DS_SC], + blk, &seq[pos-1], &out_sz2) + : (seq[pos-1] = 'N', out_sz2 = 1, 0); + break; + +// default: +// r |= c->comp_hdr->codecs[DS_BB] +// ? c->comp_hdr->codecs[DS_BB] +// ->decode(s, c->comp_hdr->codecs[DS_BB], +// blk, &seq[pos-1], &out_sz2) +// : (seq[pos-1] = 'N', out_sz2 = 1, 0); + } + cigar[ncigar++] = (out_sz2<<4) + BAM_CSOFT_CLIP; + cig_op = BAM_CSOFT_CLIP; + seq_pos += out_sz2; + } + break; + } + + case 'X': { // Substitution; BS + unsigned char base; +#ifdef USE_X + if (cig_len && cig_op != BAM_CBASE_MISMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_BS) { + if (!c->comp_hdr->codecs[DS_BS]) return -1; + r |= c->comp_hdr->codecs[DS_BS] + ->decode(s, c->comp_hdr->codecs[DS_BS], blk, + (char *)&base, &out_sz); + seq[pos-1] = 'N'; // FIXME look up BS=base value + } + cig_op = BAM_CBASE_MISMATCH; +#else + int ref_base; + if (cig_len && cig_op != BAM_CMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_BS) { + if (!c->comp_hdr->codecs[DS_BS]) return -1; + r |= c->comp_hdr->codecs[DS_BS] + ->decode(s, c->comp_hdr->codecs[DS_BS], blk, + (char *)&base, &out_sz); + if (ref_pos >= bfd->ref[cr->ref_id].len || !s->ref) { + seq[pos-1] = 'N'; + } else { + ref_base = fd->L1[(uc)s->ref[ref_pos - s->ref_start +1]]; + seq[pos-1] = c->comp_hdr-> + substitution_matrix[ref_base][base]; + if (decode_md) { + BLOCK_APPEND_UINT(s->aux_blk, md_dist); + BLOCK_APPEND_CHAR(s->aux_blk, + s->ref[ref_pos-s->ref_start +1]); + md_dist = 0; + } + } + } + cig_op = BAM_CMATCH; +#endif + nm++; + cig_len++; + seq_pos++; + ref_pos++; + break; + } + + case 'D': { // Deletion; DL + if (cig_len && cig_op != BAM_CDEL) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_DL) { + if (!c->comp_hdr->codecs[DS_DL]) return -1; + r |= c->comp_hdr->codecs[DS_DL] + ->decode(s, c->comp_hdr->codecs[DS_DL], blk, + (char *)&i32, &out_sz); + if (decode_md) { + BLOCK_APPEND_UINT(s->aux_blk, md_dist); + BLOCK_APPEND_CHAR(s->aux_blk, '^'); + BLOCK_APPEND(s->aux_blk, + &s->ref[ref_pos - s->ref_start +1], + i32); + md_dist = 0; + } + cig_op = BAM_CDEL; + cig_len += i32; + ref_pos += i32; + nm += i32; + //printf(" %d: DL = %d (ret %d)\n", f, i32, r); + } + break; + } + + case 'I': { // Insertion (several bases); IN + int32_t out_sz2 = 1; + + if (cig_len && cig_op != BAM_CINS) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + + if (ds & CRAM_IN) { + if (!c->comp_hdr->codecs[DS_IN]) return -1; + r |= c->comp_hdr->codecs[DS_IN] + ->decode(s, c->comp_hdr->codecs[DS_IN], blk, + &seq[pos-1], &out_sz2); + cig_op = BAM_CINS; + cig_len += out_sz2; + seq_pos += out_sz2; + nm += out_sz2; + //printf(" %d: IN(I) = %.*s (ret %d, out_sz %d)\n", f, out_sz2, dat, r, out_sz2); + } + break; + } + + case 'i': { // Insertion (single base); BA + if (cig_len && cig_op != BAM_CINS) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_BA) { + if (!c->comp_hdr->codecs[DS_BA]) return -1; + r |= c->comp_hdr->codecs[DS_BA] + ->decode(s, c->comp_hdr->codecs[DS_BA], blk, + (char *)&seq[pos-1], &out_sz); + } + cig_op = BAM_CINS; + cig_len++; + seq_pos++; + nm++; + break; + } + + case 'b': { // Several bases + int32_t len = 1; + + if (cig_len && cig_op != BAM_CMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + + if (ds & CRAM_BB) { + if (!c->comp_hdr->codecs[DS_BB]) return -1; + r |= c->comp_hdr->codecs[DS_BB] + ->decode(s, c->comp_hdr->codecs[DS_BB], blk, + (char *)&seq[pos-1], &len); + } + + cig_op = BAM_CMATCH; + + cig_len+=len; + seq_pos+=len; + ref_pos+=len; + //prev_pos+=len; + break; + } + + case 'q': { // Several quality values + int32_t len = 1; + + if (cig_len && cig_op != BAM_CMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + + if (ds & CRAM_QQ) { + if (!c->comp_hdr->codecs[DS_QQ]) return -1; + r |= c->comp_hdr->codecs[DS_QQ] + ->decode(s, c->comp_hdr->codecs[DS_QQ], blk, + (char *)&qual[pos-1], &len); + } + + cig_op = BAM_CMATCH; + + cig_len+=len; + seq_pos+=len; + ref_pos+=len; + //prev_pos+=len; + break; + } + + case 'B': { // Read base; BA, QS +#ifdef USE_X + if (cig_len && cig_op != BAM_CBASE_MISMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } +#else + if (cig_len && cig_op != BAM_CMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } +#endif + if (ds & CRAM_BA) { + if (!c->comp_hdr->codecs[DS_BA]) return -1; + r |= c->comp_hdr->codecs[DS_BA] + ->decode(s, c->comp_hdr->codecs[DS_BA], blk, + (char *)&seq[pos-1], &out_sz); + } + if (ds & CRAM_QS) { + if (!c->comp_hdr->codecs[DS_QS]) return -1; + r |= c->comp_hdr->codecs[DS_QS] + ->decode(s, c->comp_hdr->codecs[DS_QS], blk, + (char *)&qual[pos-1], &out_sz); + } +#ifdef USE_X + cig_op = BAM_CBASE_MISMATCH; +#else + cig_op = BAM_CMATCH; +#endif + cig_len++; + seq_pos++; + ref_pos++; + //printf(" %d: BA/QS(B) = %c/%d (ret %d)\n", f, i32, qc, r); + break; + } + + case 'Q': { // Quality score; QS + if (ds & CRAM_QS) { + if (!c->comp_hdr->codecs[DS_QS]) return -1; + r |= c->comp_hdr->codecs[DS_QS] + ->decode(s, c->comp_hdr->codecs[DS_QS], blk, + (char *)&qual[pos-1], &out_sz); + //printf(" %d: QS = %d (ret %d)\n", f, qc, r); + } + break; + } + + case 'H': { // hard clip; HC + if (cig_len && cig_op != BAM_CHARD_CLIP) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_HC) { + if (!c->comp_hdr->codecs[DS_HC]) return -1; + r |= c->comp_hdr->codecs[DS_HC] + ->decode(s, c->comp_hdr->codecs[DS_HC], blk, + (char *)&i32, &out_sz); + cig_op = BAM_CHARD_CLIP; + cig_len += i32; + nm += i32; + } + break; + } + + case 'P': { // padding; PD + if (cig_len && cig_op != BAM_CPAD) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_PD) { + if (!c->comp_hdr->codecs[DS_PD]) return -1; + r |= c->comp_hdr->codecs[DS_PD] + ->decode(s, c->comp_hdr->codecs[DS_PD], blk, + (char *)&i32, &out_sz); + cig_op = BAM_CPAD; + cig_len += i32; + nm += i32; + } + break; + } + + case 'N': { // Ref skip; RS + if (cig_len && cig_op != BAM_CREF_SKIP) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + if (ds & CRAM_RS) { + if (!c->comp_hdr->codecs[DS_RS]) return -1; + r |= c->comp_hdr->codecs[DS_RS] + ->decode(s, c->comp_hdr->codecs[DS_RS], blk, + (char *)&i32, &out_sz); + cig_op = BAM_CREF_SKIP; + cig_len += i32; + ref_pos += i32; + nm += i32; + } + break; + } + + default: + abort(); + } + } + + if (!(ds & CRAM_FC)) + goto skip_cigar; + + /* An implement match op for any unaccounted for bases */ + if ((ds & CRAM_FN) && cr->len >= seq_pos) { + if (s->ref) { + if (ref_pos + cr->len - seq_pos + 1 > bfd->ref[cr->ref_id].len) { + static int whinged = 0; + if (!whinged) + fprintf(stderr, "Ref pos outside of ref sequence boundary\n"); + whinged = 1; + } else { + memcpy(&seq[seq_pos-1], &s->ref[ref_pos - s->ref_start +1], + cr->len - seq_pos + 1); + ref_pos += cr->len - seq_pos + 1; + md_dist += cr->len - seq_pos + 1; + } + } + + if (ncigar+1 >= cigar_alloc) { + cigar_alloc = cigar_alloc ? cigar_alloc*2 : 1024; + s->cigar = cigar; + if (!(cigar = realloc(cigar, cigar_alloc * sizeof(*cigar)))) + return -1; + } +#ifdef USE_X + if (cig_len && cig_op != BAM_CBASE_MATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + cig_op = BAM_CBASE_MATCH; +#else + if (cig_len && cig_op != BAM_CMATCH) { + cigar[ncigar++] = (cig_len<<4) + cig_op; + cig_len = 0; + } + cig_op = BAM_CMATCH; +#endif + cig_len += cr->len - seq_pos+1; + } + + skip_cigar: + + if ((ds & CRAM_FN) && decode_md) { + BLOCK_APPEND_UINT(s->aux_blk, md_dist); + } + + if (cig_len) { + if (ncigar >= cigar_alloc) { + cigar_alloc = cigar_alloc ? cigar_alloc*2 : 1024; + s->cigar = cigar; + if (!(cigar = realloc(cigar, cigar_alloc * sizeof(*cigar)))) + return -1; + } + + cigar[ncigar++] = (cig_len<<4) + cig_op; + } + + cr->ncigar = ncigar - cr->cigar; + cr->aend = ref_pos; + + //printf("2: %.*s %d .. %d\n", cr->name_len, DSTRING_STR(name_ds) + cr->name, cr->apos, ref_pos); + + if (ds & CRAM_MQ) { + if (!c->comp_hdr->codecs[DS_MQ]) return -1; + r |= c->comp_hdr->codecs[DS_MQ] + ->decode(s, c->comp_hdr->codecs[DS_MQ], blk, + (char *)&cr->mqual, &out_sz); + } else { + cr->mqual = 40; + } + + if ((ds & CRAM_QS) && (cf & CRAM_FLAG_PRESERVE_QUAL_SCORES)) { + int32_t out_sz2 = cr->len; + + if (ds & CRAM_QS) { + if (!c->comp_hdr->codecs[DS_QS]) return -1; + r |= c->comp_hdr->codecs[DS_QS] + ->decode(s, c->comp_hdr->codecs[DS_QS], blk, + qual, &out_sz2); + } + } + + s->cigar = cigar; + s->cigar_alloc = cigar_alloc; + s->ncigar = ncigar; + + if (decode_md) { + char buf[7]; + BLOCK_APPEND_CHAR(s->aux_blk, '\0'); // null terminate MD:Z: + cr->aux_size += BLOCK_SIZE(s->aux_blk) - orig_aux; + buf[0] = 'N'; buf[1] = 'M'; buf[2] = 'I'; + buf[3] = (nm>> 0) & 0xff; + buf[4] = (nm>> 8) & 0xff; + buf[5] = (nm>>16) & 0xff; + buf[6] = (nm>>24) & 0xff; + BLOCK_APPEND(s->aux_blk, buf, 7); + cr->aux_size += 7; + } + + return r; +} + +/* + * Quick and simple hash lookup for cram_map arrays + */ +static cram_map *map_find(cram_map **map, unsigned char *key, int id) { + cram_map *m; + + m = map[CRAM_MAP(key[0],key[1])]; + while (m && m->key != id) + m= m->next; + + return m; +} + +//#define map_find(M,K,I) M[CRAM_MAP(K[0],K[1])];while (m && m->key != I);m= m->next + + +static int cram_decode_aux_1_0(cram_container *c, cram_slice *s, + cram_block *blk, cram_record *cr) { + int i, r = 0, out_sz = 1; + unsigned char ntags; + + if (!c->comp_hdr->codecs[DS_TC]) return -1; + r |= c->comp_hdr->codecs[DS_TC]->decode(s, c->comp_hdr->codecs[DS_TC], blk, + (char *)&ntags, &out_sz); + cr->ntags = ntags; + + //printf("TC=%d\n", cr->ntags); + cr->aux_size = 0; + cr->aux = BLOCK_SIZE(s->aux_blk); + + for (i = 0; i < cr->ntags; i++) { + int32_t id, out_sz = 1; + unsigned char tag_data[3]; + cram_map *m; + + //printf("Tag %d/%d\n", i+1, cr->ntags); + if (!c->comp_hdr->codecs[DS_TN]) return -1; + r |= c->comp_hdr->codecs[DS_TN]->decode(s, c->comp_hdr->codecs[DS_TN], + blk, (char *)&id, &out_sz); + if (out_sz == 3) { + tag_data[0] = ((char *)&id)[0]; + tag_data[1] = ((char *)&id)[1]; + tag_data[2] = ((char *)&id)[2]; + } else { + tag_data[0] = (id>>16) & 0xff; + tag_data[1] = (id>>8) & 0xff; + tag_data[2] = id & 0xff; + } + + m = map_find(c->comp_hdr->tag_encoding_map, tag_data, id); + if (!m) + return -1; + BLOCK_APPEND(s->aux_blk, (char *)tag_data, 3); + + if (!m->codec) return -1; + r |= m->codec->decode(s, m->codec, blk, (char *)s->aux_blk, &out_sz); + + cr->aux_size += out_sz + 3; + } + + return r; +} + +static int cram_decode_aux(cram_container *c, cram_slice *s, + cram_block *blk, cram_record *cr) { + int i, r = 0, out_sz = 1; + int32_t TL = 0; + unsigned char *TN; + uint32_t ds = c->comp_hdr->data_series; + + if (!(ds & (CRAM_TL|CRAM_aux))) { + cr->aux = 0; + cr->aux_size = 0; + return 0; + } + + if (!c->comp_hdr->codecs[DS_TL]) return -1; + r |= c->comp_hdr->codecs[DS_TL]->decode(s, c->comp_hdr->codecs[DS_TL], blk, + (char *)&TL, &out_sz); + if (r || TL < 0 || TL >= c->comp_hdr->nTL) + return -1; + + TN = c->comp_hdr->TL[TL]; + cr->ntags = strlen((char *)TN)/3; // optimise to remove strlen + + //printf("TC=%d\n", cr->ntags); + cr->aux_size = 0; + cr->aux = BLOCK_SIZE(s->aux_blk); + + if (!(ds & CRAM_aux)) + return 0; + + for (i = 0; i < cr->ntags; i++) { + int32_t id, out_sz = 1; + unsigned char tag_data[3]; + cram_map *m; + + //printf("Tag %d/%d\n", i+1, cr->ntags); + tag_data[0] = *TN++; + tag_data[1] = *TN++; + tag_data[2] = *TN++; + id = (tag_data[0]<<16) | (tag_data[1]<<8) | tag_data[2]; + + m = map_find(c->comp_hdr->tag_encoding_map, tag_data, id); + if (!m) + return -1; + BLOCK_APPEND(s->aux_blk, (char *)tag_data, 3); + + if (!m->codec) return -1; + r |= m->codec->decode(s, m->codec, blk, (char *)s->aux_blk, &out_sz); + cr->aux_size += out_sz + 3; + } + + return r; +} + +/* Resolve mate pair cross-references between recs within this slice */ +static void cram_decode_slice_xref(cram_slice *s, int required_fields) { + int rec; + + if (!(required_fields & (SAM_RNEXT | SAM_PNEXT | SAM_TLEN))) { + for (rec = 0; rec < s->hdr->num_records; rec++) { + cram_record *cr = &s->crecs[rec]; + + cr->tlen = 0; + cr->mate_pos = 0; + cr->mate_ref_id = -1; + } + + return; + } + + for (rec = 0; rec < s->hdr->num_records; rec++) { + cram_record *cr = &s->crecs[rec]; + + if (cr->mate_line >= 0) { + if (cr->mate_line < s->hdr->num_records) { + /* + * On the first read, loop through computing lengths. + * It's not perfect as we have one slice per reference so we + * cannot detect when TLEN should be zero due to seqs that + * map to multiple references. + * + * We also cannot set tlen correct when it spans a slice for + * other reasons. This may make tlen too small. Should we + * fix this by forcing TLEN to be stored verbatim in such cases? + * + * Or do we just admit defeat and output 0 for tlen? It's the + * safe option... + */ + if (cr->tlen == INT_MIN) { + int id1 = rec, id2 = rec; + int aleft = cr->apos, aright = cr->aend; + int tlen; + int ref = cr->ref_id; + + // number of segments starting at the same point. + int left_cnt = 0; + + do { + if (aleft > s->crecs[id2].apos) + aleft = s->crecs[id2].apos, left_cnt = 1; + else if (aleft == s->crecs[id2].apos) + left_cnt++; + if (aright < s->crecs[id2].aend) + aright = s->crecs[id2].aend; + if (s->crecs[id2].mate_line == -1) { + s->crecs[id2].mate_line = rec; + break; + } + assert(s->crecs[id2].mate_line > id2); + id2 = s->crecs[id2].mate_line; + + if (s->crecs[id2].ref_id != ref) + ref = -1; + } while (id2 != id1); + + if (ref != -1) { + tlen = aright - aleft + 1; + id1 = id2 = rec; + + /* + * When we have two seqs with identical start and + * end coordinates, set +/- tlen based on 1st/last + * bit flags instead, as a tie breaker. + */ + if (s->crecs[id2].apos == aleft) { + if (left_cnt == 1 || + (s->crecs[id2].flags & BAM_FREAD1)) + s->crecs[id2].tlen = tlen; + else + s->crecs[id2].tlen = -tlen; + } else { + s->crecs[id2].tlen = -tlen; + } + + id2 = s->crecs[id2].mate_line; + while (id2 != id1) { + if (s->crecs[id2].apos == aleft) { + if (left_cnt == 1 || + (s->crecs[id2].flags & BAM_FREAD1)) + s->crecs[id2].tlen = tlen; + else + s->crecs[id2].tlen = -tlen; + } else { + s->crecs[id2].tlen = -tlen; + } + id2 = s->crecs[id2].mate_line; + } + } else { + id1 = id2 = rec; + + s->crecs[id2].tlen = 0; + id2 = s->crecs[id2].mate_line; + while (id2 != id1) { + s->crecs[id2].tlen = 0; + id2 = s->crecs[id2].mate_line; + } + } + } + + cr->mate_pos = s->crecs[cr->mate_line].apos; + cr->mate_ref_id = s->crecs[cr->mate_line].ref_id; + + // paired + cr->flags |= BAM_FPAIRED; + + // set mate unmapped if needed + if (s->crecs[cr->mate_line].flags & BAM_FUNMAP) { + cr->flags |= BAM_FMUNMAP; + cr->tlen = 0; + } + if (cr->flags & BAM_FUNMAP) { + cr->tlen = 0; + } + + // set mate reversed if needed + if (s->crecs[cr->mate_line].flags & BAM_FREVERSE) + cr->flags |= BAM_FMREVERSE; + } else { + fprintf(stderr, "Mate line out of bounds: %d vs [0, %d]\n", + cr->mate_line, s->hdr->num_records-1); + } + + /* FIXME: construct read names here too if needed */ + } else { + if (cr->mate_flags & CRAM_M_REVERSE) { + cr->flags |= BAM_FPAIRED | BAM_FMREVERSE; + } + if (cr->mate_flags & CRAM_M_UNMAP) { + cr->flags |= BAM_FMUNMAP; + //cr->mate_ref_id = -1; + } + if (!(cr->flags & BAM_FPAIRED)) + cr->mate_ref_id = -1; + } + + if (cr->tlen == INT_MIN) + cr->tlen = 0; // Just incase + } +} + +static char *md5_print(unsigned char *md5, char *out) { + int i; + for (i = 0; i < 16; i++) { + out[i*2+0] = "0123456789abcdef"[md5[i]>>4]; + out[i*2+1] = "0123456789abcdef"[md5[i]&15]; + } + out[32] = 0; + + return out; +} + +/* + * Decode an entire slice from container blocks. Fills out s->crecs[] array. + * Returns 0 on success + * -1 on failure + */ +int cram_decode_slice(cram_fd *fd, cram_container *c, cram_slice *s, + SAM_hdr *bfd) { + cram_block *blk = s->block[0]; + int32_t bf, ref_id; + unsigned char cf; + int out_sz, r = 0; + int rec; + char *seq = NULL, *qual = NULL; + int unknown_rg = -1; + int embed_ref; + char **refs = NULL; + uint32_t ds; + + if (cram_dependent_data_series(fd, c->comp_hdr, s) != 0) + return -1; + + ds = c->comp_hdr->data_series; + + blk->bit = 7; // MSB first + + /* Look for unknown RG, added as last by Java CRAM? */ + if (bfd->nrg > 0 && + !strcmp(bfd->rg[bfd->nrg-1].name, "UNKNOWN")) + unknown_rg = bfd->nrg-1; + + if (blk->content_type != CORE) + return -1; + + if (s->crecs) + free(s->crecs); + if (!(s->crecs = malloc(s->hdr->num_records * sizeof(*s->crecs)))) + return -1; + + ref_id = s->hdr->ref_seq_id; + embed_ref = s->hdr->ref_base_id >= 0 ? 1 : 0; + + if (ref_id >= 0) { + if (embed_ref) { + cram_block *b; + if (s->hdr->ref_base_id < 0) { + fprintf(stderr, "No reference specified and " + "no embedded reference is available.\n"); + return -1; + } + if (!s->block_by_id || + !(b = s->block_by_id[s->hdr->ref_base_id])) + return -1; + cram_uncompress_block(b); + s->ref = (char *)BLOCK_DATA(b); + s->ref_start = s->hdr->ref_seq_start; + s->ref_end = s->hdr->ref_seq_start + s->hdr->ref_seq_span-1; + } else if (!fd->no_ref) { + //// Avoid Java cramtools bug by loading entire reference seq + //s->ref = cram_get_ref(fd, s->hdr->ref_seq_id, 1, 0); + //s->ref_start = 1; + + if (fd->required_fields & SAM_SEQ) + s->ref = + cram_get_ref(fd, s->hdr->ref_seq_id, + s->hdr->ref_seq_start, + s->hdr->ref_seq_start + s->hdr->ref_seq_span -1); + s->ref_start = s->hdr->ref_seq_start; + s->ref_end = s->hdr->ref_seq_start + s->hdr->ref_seq_span-1; + + /* Sanity check */ + if (s->ref_start < 0) { + fprintf(stderr, "Slice starts before base 1.\n"); + s->ref_start = 0; + } + pthread_mutex_lock(&fd->ref_lock); + pthread_mutex_lock(&fd->refs->lock); + if ((fd->required_fields & SAM_SEQ) && + s->ref_end > fd->refs->ref_id[ref_id]->length) { + fprintf(stderr, "Slice ends beyond reference end.\n"); + s->ref_end = fd->refs->ref_id[ref_id]->length; + } + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + } + } + + if ((fd->required_fields & SAM_SEQ) && + s->ref == NULL && s->hdr->ref_seq_id >= 0 && !fd->no_ref) { + fprintf(stderr, "Unable to fetch reference #%d %d..%d\n", + s->hdr->ref_seq_id, s->hdr->ref_seq_start, + s->hdr->ref_seq_start + s->hdr->ref_seq_span-1); + return -1; + } + + if (CRAM_MAJOR_VERS(fd->version) != 1 + && (fd->required_fields & SAM_SEQ) + && s->hdr->ref_seq_id >= 0 + && !fd->ignore_md5 + && memcmp(s->hdr->md5, "\0\0\0\0\0\0\0\0\0\0\0\0\0\0\0\0", 16)) { + MD5_CTX md5; + unsigned char digest[16]; + + if (s->ref && s->hdr->ref_seq_id >= 0) { + int start, len; + + if (s->hdr->ref_seq_start >= s->ref_start) { + start = s->hdr->ref_seq_start - s->ref_start; + } else { + fprintf(stderr, "Slice starts before base 1.\n"); + start = 0; + } + + if (s->hdr->ref_seq_span <= s->ref_end - s->ref_start + 1) { + len = s->hdr->ref_seq_span; + } else { + fprintf(stderr, "Slice ends beyond reference end.\n"); + len = s->ref_end - s->ref_start + 1; + } + + MD5_Init(&md5); + if (start + len > s->ref_end - s->ref_start + 1) + len = s->ref_end - s->ref_start + 1 - start; + if (len >= 0) + MD5_Update(&md5, s->ref + start, len); + MD5_Final(digest, &md5); + } else if (!s->ref && s->hdr->ref_base_id >= 0) { + cram_block *b; + if (s->block_by_id && (b = s->block_by_id[s->hdr->ref_base_id])) { + MD5_Init(&md5); + MD5_Update(&md5, b->data, b->uncomp_size); + MD5_Final(digest, &md5); + } + } + + if ((!s->ref && s->hdr->ref_base_id < 0) + || memcmp(digest, s->hdr->md5, 16) != 0) { + char M[33]; + fprintf(stderr, "ERROR: md5sum reference mismatch for ref " + "%d pos %d..%d\n", ref_id, s->ref_start, s->ref_end); + fprintf(stderr, "CRAM: %s\n", md5_print(s->hdr->md5, M)); + fprintf(stderr, "Ref : %s\n", md5_print(digest, M)); + return -1; + } + } + + if (ref_id == -2) { + pthread_mutex_lock(&fd->ref_lock); + pthread_mutex_lock(&fd->refs->lock); + refs = calloc(fd->refs->nref, sizeof(char *)); + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + if (!refs) + return -1; + } + + for (rec = 0; rec < s->hdr->num_records; rec++) { + cram_record *cr = &s->crecs[rec]; + + //fprintf(stderr, "Decode seq %d, %d/%d\n", rec, blk->byte, blk->bit); + + cr->s = s; + + out_sz = 1; /* decode 1 item */ + if (ds & CRAM_BF) { + if (!c->comp_hdr->codecs[DS_BF]) return -1; + r |= c->comp_hdr->codecs[DS_BF] + ->decode(s, c->comp_hdr->codecs[DS_BF], blk, + (char *)&bf, &out_sz); + if (bf < 0 || + bf >= sizeof(fd->bam_flag_swap)/sizeof(*fd->bam_flag_swap)) + return -1; + bf = fd->bam_flag_swap[bf]; + cr->flags = bf; + } else { + cr->flags = bf = 0x4; // unmapped + } + + if (ds & CRAM_CF) { + if (CRAM_MAJOR_VERS(fd->version) == 1) { + /* CF is byte in 1.0, int32 in 2.0 */ + if (!c->comp_hdr->codecs[DS_CF]) return -1; + r |= c->comp_hdr->codecs[DS_CF] + ->decode(s, c->comp_hdr->codecs[DS_CF], blk, + (char *)&cf, &out_sz); + cr->cram_flags = cf; + } else { + if (!c->comp_hdr->codecs[DS_CF]) return -1; + r |= c->comp_hdr->codecs[DS_CF] + ->decode(s, c->comp_hdr->codecs[DS_CF], blk, + (char *)&cr->cram_flags, + &out_sz); + cf = cr->cram_flags; + } + } + + if (CRAM_MAJOR_VERS(fd->version) != 1 && ref_id == -2) { + if (ds & CRAM_RI) { + if (!c->comp_hdr->codecs[DS_RI]) return -1; + r |= c->comp_hdr->codecs[DS_RI] + ->decode(s, c->comp_hdr->codecs[DS_RI], blk, + (char *)&cr->ref_id, &out_sz); + if ((fd->required_fields & (SAM_SEQ|SAM_TLEN)) + && cr->ref_id >= 0) { + if (!fd->no_ref) { + if (!refs[cr->ref_id]) + refs[cr->ref_id] = cram_get_ref(fd, cr->ref_id, + 1, 0); + s->ref = refs[cr->ref_id]; + } + s->ref_start = 1; + pthread_mutex_lock(&fd->ref_lock); + pthread_mutex_lock(&fd->refs->lock); + s->ref_end = fd->refs->ref_id[cr->ref_id]->length; + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + } + } else { + cr->ref_id = 0; + } + } else { + cr->ref_id = ref_id; // Forced constant in CRAM 1.0 + } + + + if (ds & CRAM_RL) { + if (!c->comp_hdr->codecs[DS_RL]) return -1; + r |= c->comp_hdr->codecs[DS_RL] + ->decode(s, c->comp_hdr->codecs[DS_RL], blk, + (char *)&cr->len, &out_sz); + } + + if (ds & CRAM_AP) { + if (!c->comp_hdr->codecs[DS_AP]) return -1; + r |= c->comp_hdr->codecs[DS_AP] + ->decode(s, c->comp_hdr->codecs[DS_AP], blk, + (char *)&cr->apos, &out_sz); + if (c->comp_hdr->AP_delta) + cr->apos += s->last_apos; + s->last_apos= cr->apos; + } else { + cr->apos = c->ref_seq_start; + } + + if (ds & CRAM_RG) { + if (!c->comp_hdr->codecs[DS_RG]) return -1; + r |= c->comp_hdr->codecs[DS_RG] + ->decode(s, c->comp_hdr->codecs[DS_RG], blk, + (char *)&cr->rg, &out_sz); + if (cr->rg == unknown_rg) + cr->rg = -1; + } else { + cr->rg = -1; + } + + cr->name_len = 0; + + if (c->comp_hdr->read_names_included) { + int32_t out_sz2 = 1; + + // Read directly into name cram_block + cr->name = BLOCK_SIZE(s->name_blk); + if (ds & CRAM_RN) { + if (!c->comp_hdr->codecs[DS_RN]) return -1; + r |= c->comp_hdr->codecs[DS_RN] + ->decode(s, c->comp_hdr->codecs[DS_RN], blk, + (char *)s->name_blk, &out_sz2); + cr->name_len = out_sz2; + } + } + + cr->mate_pos = 0; + cr->mate_line = -1; + cr->mate_ref_id = -1; + if ((ds & CRAM_CF) && (cf & CRAM_FLAG_DETACHED)) { + if (ds & CRAM_MF) { + if (CRAM_MAJOR_VERS(fd->version) == 1) { + /* MF is byte in 1.0, int32 in 2.0 */ + unsigned char mf; + if (!c->comp_hdr->codecs[DS_MF]) return -1; + r |= c->comp_hdr->codecs[DS_MF] + ->decode(s, c->comp_hdr->codecs[DS_MF], + blk, (char *)&mf, &out_sz); + cr->mate_flags = mf; + } else { + if (!c->comp_hdr->codecs[DS_MF]) return -1; + r |= c->comp_hdr->codecs[DS_MF] + ->decode(s, c->comp_hdr->codecs[DS_MF], + blk, + (char *)&cr->mate_flags, + &out_sz); + } + } else { + cr->mate_flags = 0; + } + + if (!c->comp_hdr->read_names_included) { + int32_t out_sz2 = 1; + + // Read directly into name cram_block + cr->name = BLOCK_SIZE(s->name_blk); + if (ds & CRAM_RN) { + if (!c->comp_hdr->codecs[DS_RN]) return -1; + r |= c->comp_hdr->codecs[DS_RN] + ->decode(s, c->comp_hdr->codecs[DS_RN], + blk, (char *)s->name_blk, + &out_sz2); + cr->name_len = out_sz2; + } + } + + if (ds & CRAM_NS) { + if (!c->comp_hdr->codecs[DS_NS]) return -1; + r |= c->comp_hdr->codecs[DS_NS] + ->decode(s, c->comp_hdr->codecs[DS_NS], blk, + (char *)&cr->mate_ref_id, &out_sz); + } + +// Skip as mate_ref of "*" is legit. It doesn't mean unmapped, just unknown. +// if (cr->mate_ref_id == -1 && cr->flags & 0x01) { +// /* Paired, but unmapped */ +// cr->flags |= BAM_FMUNMAP; +// } + + if (ds & CRAM_NP) { + if (!c->comp_hdr->codecs[DS_NP]) return -1; + r |= c->comp_hdr->codecs[DS_NP] + ->decode(s, c->comp_hdr->codecs[DS_NP], blk, + (char *)&cr->mate_pos, &out_sz); + } + + if (ds & CRAM_TS) { + if (!c->comp_hdr->codecs[DS_TS]) return -1; + r |= c->comp_hdr->codecs[DS_TS] + ->decode(s, c->comp_hdr->codecs[DS_TS], blk, + (char *)&cr->tlen, &out_sz); + } else { + cr->tlen = INT_MIN; + } + } else if ((ds & CRAM_CF) && (cf & CRAM_FLAG_MATE_DOWNSTREAM)) { + if (ds & CRAM_NF) { + if (!c->comp_hdr->codecs[DS_NF]) return -1; + r |= c->comp_hdr->codecs[DS_NF] + ->decode(s, c->comp_hdr->codecs[DS_NF], blk, + (char *)&cr->mate_line, &out_sz); + cr->mate_line += rec + 1; + + //cr->name_len = sprintf(name, "%d", name_id++); + //cr->name = DSTRING_LEN(name_ds); + //dstring_nappend(name_ds, name, cr->name_len); + + cr->mate_ref_id = -1; + cr->tlen = INT_MIN; + cr->mate_pos = 0; + } else { + cr->mate_flags = 0; + cr->tlen = INT_MIN; + } + } else { + cr->mate_flags = 0; + cr->tlen = INT_MIN; + } + /* + else if (!name[0]) { + //name[0] = '?'; name[1] = 0; + //cr->name_len = 1; + //cr->name= DSTRING_LEN(s->name_ds); + //dstring_nappend(s->name_ds, "?", 1); + + cr->mate_ref_id = -1; + cr->tlen = 0; + cr->mate_pos = 0; + } + */ + + /* Auxiliary tags */ + if (CRAM_MAJOR_VERS(fd->version) == 1) + r |= cram_decode_aux_1_0(c, s, blk, cr); + else + r |= cram_decode_aux(c, s, blk, cr); + + /* Fake up dynamic string growth and appending */ + if (ds & CRAM_RL) { + cr->seq = BLOCK_SIZE(s->seqs_blk); + BLOCK_GROW(s->seqs_blk, cr->len); + seq = (char *)BLOCK_END(s->seqs_blk); + BLOCK_SIZE(s->seqs_blk) += cr->len; + + if (!seq) + return -1; + + cr->qual = BLOCK_SIZE(s->qual_blk); + BLOCK_GROW(s->qual_blk, cr->len); + qual = (char *)BLOCK_END(s->qual_blk); + BLOCK_SIZE(s->qual_blk) += cr->len; + + if (!s->ref) + memset(seq, '=', cr->len); + } + + if (!(bf & BAM_FUNMAP)) { + /* Decode sequence and generate CIGAR */ + if (ds & (CRAM_SEQ | CRAM_MQ)) { + r |= cram_decode_seq(fd, c, s, blk, cr, bfd, cf, seq, qual); + } else { + cr->cigar = 0; + cr->ncigar = 0; + cr->aend = cr->apos; + cr->mqual = 0; + } + } else { + int out_sz2 = cr->len; + + //puts("Unmapped"); + cr->cigar = 0; + cr->ncigar = 0; + cr->aend = cr->apos; + cr->mqual = 0; + + if (ds & CRAM_BA) { + if (!c->comp_hdr->codecs[DS_BA]) return -1; + r |= c->comp_hdr->codecs[DS_BA] + ->decode(s, c->comp_hdr->codecs[DS_BA], blk, + (char *)seq, &out_sz2); + } + + if ((ds & CRAM_CF) && (cf & CRAM_FLAG_PRESERVE_QUAL_SCORES)) { + out_sz2 = cr->len; + if (ds & CRAM_QS) { + if (!c->comp_hdr->codecs[DS_QS]) return -1; + r |= c->comp_hdr->codecs[DS_QS] + ->decode(s, c->comp_hdr->codecs[DS_QS], + blk, qual, &out_sz2); + } + } else { + if (ds & CRAM_RL) + memset(qual, 30, cr->len); + } + } + } + + pthread_mutex_lock(&fd->ref_lock); + if (refs) { + int i; + for (i = 0; i < fd->refs->nref; i++) { + if (refs[i]) + cram_ref_decr(fd->refs, i); + } + free(refs); + } else if (ref_id >= 0 && s->ref != fd->ref_free) { + cram_ref_decr(fd->refs, ref_id); + } + pthread_mutex_unlock(&fd->ref_lock); + + /* Resolve mate pair cross-references between recs within this slice */ + cram_decode_slice_xref(s, fd->required_fields); + + return r; +} + +typedef struct { + cram_fd *fd; + cram_container *c; + cram_slice *s; + SAM_hdr *h; + int exit_code; +} cram_decode_job; + +void *cram_decode_slice_thread(void *arg) { + cram_decode_job *j = (cram_decode_job *)arg; + + j->exit_code = cram_decode_slice(j->fd, j->c, j->s, j->h); + + return j; +} + +/* + * Spawn a multi-threaded version of cram_decode_slice(). + */ +int cram_decode_slice_mt(cram_fd *fd, cram_container *c, cram_slice *s, + SAM_hdr *bfd) { + cram_decode_job *j; + int nonblock; + + if (!fd->pool) + return cram_decode_slice(fd, c, s, bfd); + + if (!(j = malloc(sizeof(*j)))) + return -1; + + j->fd = fd; + j->c = c; + j->s = s; + j->h = bfd; + + nonblock = t_pool_results_queue_sz(fd->rqueue) ? 1 : 0; + + if (-1 == t_pool_dispatch2(fd->pool, fd->rqueue, cram_decode_slice_thread, + j, nonblock)) { + /* Would block */ + fd->job_pending = j; + } else { + fd->job_pending = NULL; + } + + // flush too + return 0; +} + + +/* ---------------------------------------------------------------------- + * CRAM sequence iterators. + */ + +/* + * Converts a cram in-memory record into a bam in-memory record. We + * pass a pointer to a bam_seq_t pointer along with the a pointer to + * the allocated size. These can initially be pointers to NULL and zero. + * + * This function will reallocate the bam buffer as required and update + * (*bam)->alloc accordingly, allowing it to be used within a loop + * efficiently without needing to allocate new bam objects over and + * over again. + * + * Returns the used size of the bam record on success + * -1 on failure. + */ +static int cram_to_bam(SAM_hdr *bfd, cram_fd *fd, cram_slice *s, + cram_record *cr, int rec, bam_seq_t **bam) { + int bam_idx, rg_len; + char name_a[1024], *name; + int name_len; + char *aux, *aux_orig; + char *seq, *qual; + + /* Assign names if not explicitly set */ + if (fd->required_fields & SAM_QNAME) { + if (cr->name_len) { + name = (char *)BLOCK_DATA(s->name_blk) + cr->name; + name_len = cr->name_len; + } else { + name = name_a; + name_len = strlen(fd->prefix); + memcpy(name, fd->prefix, name_len); + name += name_len; + *name++ = ':'; + if (cr->mate_line >= 0 && cr->mate_line < rec) + name = (char *)append_uint64((unsigned char *)name, + s->hdr->record_counter + + cr->mate_line + 1); + else + name = (char *)append_uint64((unsigned char *)name, + s->hdr->record_counter + + rec + 1); + name_len = name - name_a; + name = name_a; + } + } else { + name = "?"; + name_len = 1; + } + + /* Generate BAM record */ + if (cr->rg < -1 || cr->rg >= bfd->nrg) + return -1; + rg_len = (cr->rg != -1) ? bfd->rg[cr->rg].name_len + 4 : 0; + + if (fd->required_fields & (SAM_SEQ | SAM_QUAL)) { + if (!BLOCK_DATA(s->seqs_blk)) + return -1; + seq = (char *)BLOCK_DATA(s->seqs_blk) + cr->seq; + } else { + seq = "*"; + cr->len = 1; + } + + + if (fd->required_fields & SAM_QUAL) { + if (!BLOCK_DATA(s->qual_blk)) + return -1; + qual = (char *)BLOCK_DATA(s->qual_blk) + cr->qual; + } else { + qual = NULL; + } + + bam_idx = bam_construct_seq(bam, cr->aux_size + rg_len, + name, name_len, + cr->flags, + cr->ref_id, + cr->apos, + cr->aend, + cr->mqual, + cr->ncigar, &s->cigar[cr->cigar], + cr->mate_ref_id, + cr->mate_pos, + cr->tlen, + cr->len, + seq, + qual); + if (bam_idx == -1) + return -1; + + aux = aux_orig = (char *)bam_aux(*bam); + + /* Auxiliary strings */ + if (cr->aux_size != 0) { + memcpy(aux, BLOCK_DATA(s->aux_blk) + cr->aux, cr->aux_size); + aux += cr->aux_size; + } + + /* RG:Z: */ + if (cr->rg != -1) { + int len = bfd->rg[cr->rg].name_len; + *aux++ = 'R'; *aux++ = 'G'; *aux++ = 'Z'; + memcpy(aux, bfd->rg[cr->rg].name, len); + aux += len; + *aux++ = 0; + } + + return bam_idx + (aux - aux_orig); +} + +/* + * Here be dragons! The multi-threading code in this is crufty beyond belief. + */ +static cram_slice *cram_next_slice(cram_fd *fd, cram_container **cp) { + cram_container *c; + cram_slice *s = NULL; + + if (!(c = fd->ctr)) { + // Load first container. + do { + if (!(c = fd->ctr = cram_read_container(fd))) + return NULL; + } while (c->length == 0); + + /* + * The first container may be a result of a sub-range query. + * In which case it may still not be the optimal starting point + * due to skipped containers/slices in the index. + */ + if (fd->range.refid != -2) { + while (c->ref_seq_id != -2 && + (c->ref_seq_id < fd->range.refid || + c->ref_seq_start + c->ref_seq_span-1 < fd->range.start)) { + if (0 != cram_seek(fd, c->length, SEEK_CUR)) + return NULL; + cram_free_container(fd->ctr); + do { + if (!(c = fd->ctr = cram_read_container(fd))) + return NULL; + } while (c->length == 0); + } + + if (c->ref_seq_id != -2 && c->ref_seq_id != fd->range.refid) + return NULL; + } + + if (!(c->comp_hdr_block = cram_read_block(fd))) + return NULL; + if (c->comp_hdr_block->content_type != COMPRESSION_HEADER) + return NULL; + + c->comp_hdr = cram_decode_compression_header(fd, c->comp_hdr_block); + if (!c->comp_hdr) + return NULL; + if (!c->comp_hdr->AP_delta) { + pthread_mutex_lock(&fd->ref_lock); + fd->unsorted = 1; + pthread_mutex_unlock(&fd->ref_lock); + } + } + + if ((s = c->slice)) { + c->slice = NULL; + cram_free_slice(s); + s = NULL; + } + + if (c->curr_slice == c->max_slice) { + cram_free_container(c); + c = NULL; + } + + /* Sorry this is so contorted! */ + for (;;) { + if (fd->job_pending) { + cram_decode_job *j = (cram_decode_job *)fd->job_pending; + c = j->c; + s = j->s; + free(fd->job_pending); + fd->job_pending = NULL; + } else if (!fd->ooc) { + empty_container: + if (!c || c->curr_slice == c->max_slice) { + // new container + do { + if (!(c = fd->ctr = cram_read_container(fd))) { + if (fd->pool) { + fd->ooc = 1; + break; + } + + return NULL; + } + } while (c->length == 0); + if (fd->ooc) + break; + + /* Skip containers not yet spanning our range */ + if (fd->range.refid != -2 && c->ref_seq_id != -2) { + fd->required_fields |= SAM_POS; + + if (c->ref_seq_id != fd->range.refid) { + cram_free_container(c); + fd->ctr = NULL; + fd->ooc = 1; + fd->eof = 1; + break; + } + + if (c->ref_seq_start > fd->range.end) { + cram_free_container(c); + fd->ctr = NULL; + fd->ooc = 1; + fd->eof = 1; + break; + } + + if (c->ref_seq_start + c->ref_seq_span-1 < + fd->range.start) { + c->curr_rec = c->max_rec; + c->curr_slice = c->max_slice; + cram_seek(fd, c->length, SEEK_CUR); + cram_free_container(c); + c = NULL; + continue; + } + } + + if (!(c->comp_hdr_block = cram_read_block(fd))) + return NULL; + if (c->comp_hdr_block->content_type != COMPRESSION_HEADER) + return NULL; + + c->comp_hdr = + cram_decode_compression_header(fd, c->comp_hdr_block); + if (!c->comp_hdr) + return NULL; + + if (!c->comp_hdr->AP_delta) { + pthread_mutex_lock(&fd->ref_lock); + fd->unsorted = 1; + pthread_mutex_unlock(&fd->ref_lock); + } + } + + if (c->num_records == 0) { + cram_free_container(c); c = NULL; + goto empty_container; + } + + + if (!(s = c->slice = cram_read_slice(fd))) + return NULL; + c->curr_slice++; + c->curr_rec = 0; + c->max_rec = s->hdr->num_records; + + s->last_apos = s->hdr->ref_seq_start; + + /* Skip slices not yet spanning our range */ + if (fd->range.refid != -2 && s->hdr->ref_seq_id != -2) { + if (s->hdr->ref_seq_id != fd->range.refid) { + fd->eof = 1; + cram_free_slice(s); + c->slice = NULL; + return NULL; + } + + if (s->hdr->ref_seq_start > fd->range.end) { + fd->eof = 1; + cram_free_slice(s); + c->slice = NULL; + return NULL; + } + + if (s->hdr->ref_seq_start + s->hdr->ref_seq_span-1 < + fd->range.start) { + cram_free_slice(s); + c->slice = NULL; + cram_free_container(c); + c = NULL; + continue; + } + } + } + + /* Test decoding of 1st seq */ + if (!c || !s) + break; + + if (cram_decode_slice_mt(fd, c, s, fd->header) != 0) { + // if (cram_decode_slice(fd, c, s, fd->header) != 0) { + fprintf(stderr, "Failure to decode slice\n"); + cram_free_slice(s); + c->slice = NULL; + return NULL; + } + + if (!fd->pool || fd->job_pending) + break; + + // Push it a bit far, to qsize in queue rather than pending arrival, + // as cram tends to be a bit bursty in decode timings. + if (t_pool_results_queue_len(fd->rqueue) > fd->pool->qsize) + break; + } + + if (fd->pool) { + t_pool_result *res; + cram_decode_job *j; + +// fprintf(stderr, "Thread pool len = %d, %d\n", +// t_pool_results_queue_len(fd->rqueue), +// t_pool_results_queue_sz(fd->rqueue)); + + if (fd->ooc && t_pool_results_queue_empty(fd->rqueue)) + return NULL; + + res = t_pool_next_result_wait(fd->rqueue); + + if (!res || !res->data) { + fprintf(stderr, "t_pool_next_result failure\n"); + return NULL; + } + + j = (cram_decode_job *)res->data; + c = j->c; + s = j->s; + + fd->ctr = c; + + t_pool_delete_result(res, 1); + } + + *cp = c; + return s; +} + +/* + * Read the next cram record and return it. + * Note that to decode cram_record the caller will need to look up some data + * in the current slice, pointed to by fd->ctr->slice. This is valid until + * the next call to cram_get_seq (which may invalidate it). + * + * Returns record pointer on success (do not free) + * NULL on failure + */ +cram_record *cram_get_seq(cram_fd *fd) { + cram_container *c; + cram_slice *s; + + for (;;) { + c = fd->ctr; + if (c && c->slice && c->curr_rec < c->max_rec) { + s = c->slice; + } else { + if (!(s = cram_next_slice(fd, &c))) + return NULL; + } + + if (fd->range.refid != -2) { + if (s->crecs[c->curr_rec].ref_id < fd->range.refid) { + c->curr_rec++; + continue; + } + + if (s->crecs[c->curr_rec].ref_id != fd->range.refid) { + fd->eof = 1; + cram_free_slice(s); + c->slice = NULL; + return NULL; + } + + if (s->crecs[c->curr_rec].apos > fd->range.end) { + fd->eof = 1; + cram_free_slice(s); + c->slice = NULL; + return NULL; + } + + if (s->crecs[c->curr_rec].aend < fd->range.start) { + c->curr_rec++; + continue; + } + } + + break; + } + + fd->ctr = c; + c->slice = s; + return &s->crecs[c->curr_rec++]; +} + +/* + * Read the next cram record and convert it to a bam_seq_t struct. + * + * Returns 0 on success + * -1 on EOF or failure (check fd->err) + */ +int cram_get_bam_seq(cram_fd *fd, bam_seq_t **bam) { + cram_record *cr; + cram_container *c; + cram_slice *s; + + if (!(cr = cram_get_seq(fd))) + return -1; + + c = fd->ctr; + s = c->slice; + + return cram_to_bam(fd->header, fd, s, cr, c->curr_rec-1, bam); +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_decode.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,112 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/*! \file + * Include cram.h instead. + * + * This is an internal part of the CRAM system and is automatically included + * when you #include cram.h. + * + * Implements the decoding portion of CRAM I/O. Also see + * cram_codecs.[ch] for the actual encoding functions themselves. + */ + +#ifndef _CRAM_READ_H_ +#define _CRAM_READ_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +/* ---------------------------------------------------------------------- + * CRAM sequence iterators. + */ + +/*! Read the next cram record and return it as a cram_record. + * + * Note that to decode cram_record the caller will need to look up some data + * in the current slice, pointed to by fd->ctr->slice. This is valid until + * the next call to cram_get_seq (which may invalidate it). + * + * @return + * Returns record pointer on success (do not free); + * NULL on failure + */ +cram_record *cram_get_seq(cram_fd *fd); + +/*! Read the next cram record and convert it to a bam_seq_t struct. + * + * @return + * Returns 0 on success; + * -1 on EOF or failure (check fd->err) + */ +int cram_get_bam_seq(cram_fd *fd, bam_seq_t **bam); + + +/* ---------------------------------------------------------------------- + * Internal functions + */ + +/*! INTERNAL: + * Decodes a CRAM block compression header. + * + * @return + * Returns header ptr on success; + * NULL on failure + */ +cram_block_compression_hdr *cram_decode_compression_header(cram_fd *fd, + cram_block *b); + +/*! INTERNAL: + * Decodes a CRAM (un)mapped slice header block. + * + * @return + * Returns slice header ptr on success; + * NULL on failure + */ +cram_block_slice_hdr *cram_decode_slice_header(cram_fd *fd, cram_block *b); + + +/*! INTERNAL: + * Decode an entire slice from container blocks. Fills out s->crecs[] array. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_decode_slice(cram_fd *fd, cram_container *c, cram_slice *s, + SAM_hdr *hdr); + + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_encode.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3068 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdio.h> +#include <errno.h> +#include <assert.h> +#include <stdlib.h> +#include <string.h> +#include <zlib.h> +#include <sys/types.h> +#include <sys/stat.h> +#include <math.h> +#include <ctype.h> + +#include "cram/cram.h" +#include "cram/os.h" +#include "cram/md5.h" + +#define Z_CRAM_STRAT Z_FILTERED +//#define Z_CRAM_STRAT Z_RLE +//#define Z_CRAM_STRAT Z_HUFFMAN_ONLY +//#define Z_CRAM_STRAT Z_DEFAULT_STRATEGY + +static int process_one_read(cram_fd *fd, cram_container *c, + cram_slice *s, cram_record *cr, + bam_seq_t *b, int rnum); + +/* + * Returns index of val into key. + * Basically strchr(key, val)-key; + */ +static int sub_idx(char *key, char val) { + int i; + + for (i = 0; *key && *key++ != val; i++); + return i; +} + +/* + * Encodes a compression header block into a generic cram_block structure. + * + * Returns cram_block ptr on success + * NULL on failure + */ +cram_block *cram_encode_compression_header(cram_fd *fd, cram_container *c, + cram_block_compression_hdr *h) { + cram_block *cb = cram_new_block(COMPRESSION_HEADER, 0); + cram_block *map = cram_new_block(COMPRESSION_HEADER, 0); + int i, mc; + + if (!cb || !map) + return NULL; + + /* + * This is a concatenation of several blocks of data: + * header + landmarks, preservation map, read encoding map, and the tag + * encoding map. + * All 4 are variable sized and we need to know how large these are + * before creating the compression header itself as this starts with + * the total size (stored as a variable length string). + */ + + // Duplicated from container itself, and removed in 1.1 + if (CRAM_MAJOR_VERS(fd->version) == 1) { + itf8_put_blk(cb, h->ref_seq_id); + itf8_put_blk(cb, h->ref_seq_start); + itf8_put_blk(cb, h->ref_seq_span); + itf8_put_blk(cb, h->num_records); + itf8_put_blk(cb, h->num_landmarks); + for (i = 0; i < h->num_landmarks; i++) { + itf8_put_blk(cb, h->landmark[i]); + } + } + + /* Create in-memory preservation map */ + /* FIXME: should create this when we create the container */ + { + khint_t k; + int r; + + if (!(h->preservation_map = kh_init(map))) + return NULL; + + k = kh_put(map, h->preservation_map, "RN", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = 1; + + if (CRAM_MAJOR_VERS(fd->version) == 1) { + k = kh_put(map, h->preservation_map, "PI", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = 0; + + k = kh_put(map, h->preservation_map, "UI", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = 1; + + k = kh_put(map, h->preservation_map, "MI", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = 1; + + } else { + // Technically SM was in 1.0, but wasn't in Java impl. + k = kh_put(map, h->preservation_map, "SM", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = 0; + + k = kh_put(map, h->preservation_map, "TD", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = 0; + + k = kh_put(map, h->preservation_map, "AP", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = c->pos_sorted; + + if (fd->no_ref || fd->embed_ref) { + // Reference Required == No + k = kh_put(map, h->preservation_map, "RR", &r); + if (-1 == r) return NULL; + kh_val(h->preservation_map, k).i = 0; + } + } + } + + /* Encode preservation map; could collapse this and above into one */ + mc = 0; + BLOCK_SIZE(map) = 0; + if (h->preservation_map) { + khint_t k; + + for (k = kh_begin(h->preservation_map); + k != kh_end(h->preservation_map); + k++) { + const char *key; + khash_t(map) *pmap = h->preservation_map; + + + if (!kh_exist(pmap, k)) + continue; + + key = kh_key(pmap, k); + BLOCK_APPEND(map, key, 2); + + switch(CRAM_KEY(key[0], key[1])) { + case CRAM_KEY('M','I'): + BLOCK_APPEND_CHAR(map, kh_val(pmap, k).i); + break; + + case CRAM_KEY('U','I'): + BLOCK_APPEND_CHAR(map, kh_val(pmap, k).i); + break; + + case CRAM_KEY('P','I'): + BLOCK_APPEND_CHAR(map, kh_val(pmap, k).i); + break; + + case CRAM_KEY('A','P'): + BLOCK_APPEND_CHAR(map, kh_val(pmap, k).i); + break; + + case CRAM_KEY('R','N'): + BLOCK_APPEND_CHAR(map, kh_val(pmap, k).i); + break; + + case CRAM_KEY('R','R'): + BLOCK_APPEND_CHAR(map, kh_val(pmap, k).i); + break; + + case CRAM_KEY('S','M'): { + char smat[5], *mp = smat; + *mp++ = + (sub_idx("CGTN", h->substitution_matrix[0][0]) << 6) | + (sub_idx("CGTN", h->substitution_matrix[0][1]) << 4) | + (sub_idx("CGTN", h->substitution_matrix[0][2]) << 2) | + (sub_idx("CGTN", h->substitution_matrix[0][3]) << 0); + *mp++ = + (sub_idx("AGTN", h->substitution_matrix[1][0]) << 6) | + (sub_idx("AGTN", h->substitution_matrix[1][1]) << 4) | + (sub_idx("AGTN", h->substitution_matrix[1][2]) << 2) | + (sub_idx("AGTN", h->substitution_matrix[1][3]) << 0); + *mp++ = + (sub_idx("ACTN", h->substitution_matrix[2][0]) << 6) | + (sub_idx("ACTN", h->substitution_matrix[2][1]) << 4) | + (sub_idx("ACTN", h->substitution_matrix[2][2]) << 2) | + (sub_idx("ACTN", h->substitution_matrix[2][3]) << 0); + *mp++ = + (sub_idx("ACGN", h->substitution_matrix[3][0]) << 6) | + (sub_idx("ACGN", h->substitution_matrix[3][1]) << 4) | + (sub_idx("ACGN", h->substitution_matrix[3][2]) << 2) | + (sub_idx("ACGN", h->substitution_matrix[3][3]) << 0); + *mp++ = + (sub_idx("ACGT", h->substitution_matrix[4][0]) << 6) | + (sub_idx("ACGT", h->substitution_matrix[4][1]) << 4) | + (sub_idx("ACGT", h->substitution_matrix[4][2]) << 2) | + (sub_idx("ACGT", h->substitution_matrix[4][3]) << 0); + BLOCK_APPEND(map, smat, 5); + break; + } + + case CRAM_KEY('T','D'): { + itf8_put_blk(map, BLOCK_SIZE(h->TD_blk)); + BLOCK_APPEND(map, + BLOCK_DATA(h->TD_blk), + BLOCK_SIZE(h->TD_blk)); + break; + } + + default: + fprintf(stderr, "Unknown preservation key '%.2s'\n", key); + break; + } + + mc++; + } + } + itf8_put_blk(cb, BLOCK_SIZE(map) + itf8_size(mc)); + itf8_put_blk(cb, mc); + BLOCK_APPEND(cb, BLOCK_DATA(map), BLOCK_SIZE(map)); + + /* rec encoding map */ + mc = 0; + BLOCK_SIZE(map) = 0; + if (h->codecs[DS_BF]) { + if (-1 == h->codecs[DS_BF]->store(h->codecs[DS_BF], map, "BF", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_CF]) { + if (-1 == h->codecs[DS_CF]->store(h->codecs[DS_CF], map, "CF", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_RL]) { + if (-1 == h->codecs[DS_RL]->store(h->codecs[DS_RL], map, "RL", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_AP]) { + if (-1 == h->codecs[DS_AP]->store(h->codecs[DS_AP], map, "AP", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_RG]) { + if (-1 == h->codecs[DS_RG]->store(h->codecs[DS_RG], map, "RG", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_MF]) { + if (-1 == h->codecs[DS_MF]->store(h->codecs[DS_MF], map, "MF", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_NS]) { + if (-1 == h->codecs[DS_NS]->store(h->codecs[DS_NS], map, "NS", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_NP]) { + if (-1 == h->codecs[DS_NP]->store(h->codecs[DS_NP], map, "NP", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_TS]) { + if (-1 == h->codecs[DS_TS]->store(h->codecs[DS_TS], map, "TS", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_NF]) { + if (-1 == h->codecs[DS_NF]->store(h->codecs[DS_NF], map, "NF", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_TC]) { + if (-1 == h->codecs[DS_TC]->store(h->codecs[DS_TC], map, "TC", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_TN]) { + if (-1 == h->codecs[DS_TN]->store(h->codecs[DS_TN], map, "TN", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_TL]) { + if (-1 == h->codecs[DS_TL]->store(h->codecs[DS_TL], map, "TL", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_FN]) { + if (-1 == h->codecs[DS_FN]->store(h->codecs[DS_FN], map, "FN", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_FC]) { + if (-1 == h->codecs[DS_FC]->store(h->codecs[DS_FC], map, "FC", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_FP]) { + if (-1 == h->codecs[DS_FP]->store(h->codecs[DS_FP], map, "FP", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_BS]) { + if (-1 == h->codecs[DS_BS]->store(h->codecs[DS_BS], map, "BS", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_IN]) { + if (-1 == h->codecs[DS_IN]->store(h->codecs[DS_IN], map, "IN", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_DL]) { + if (-1 == h->codecs[DS_DL]->store(h->codecs[DS_DL], map, "DL", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_BA]) { + if (-1 == h->codecs[DS_BA]->store(h->codecs[DS_BA], map, "BA", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_BB]) { + if (-1 == h->codecs[DS_BB]->store(h->codecs[DS_BB], map, "BB", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_MQ]) { + if (-1 == h->codecs[DS_MQ]->store(h->codecs[DS_MQ], map, "MQ", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_RN]) { + if (-1 == h->codecs[DS_RN]->store(h->codecs[DS_RN], map, "RN", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_QS]) { + if (-1 == h->codecs[DS_QS]->store(h->codecs[DS_QS], map, "QS", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_QQ]) { + if (-1 == h->codecs[DS_QQ]->store(h->codecs[DS_QQ], map, "QQ", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_RI]) { + if (-1 == h->codecs[DS_RI]->store(h->codecs[DS_RI], map, "RI", + fd->version)) + return NULL; + mc++; + } + if (CRAM_MAJOR_VERS(fd->version) != 1) { + if (h->codecs[DS_SC]) { + if (-1 == h->codecs[DS_SC]->store(h->codecs[DS_SC], map, "SC", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_RS]) { + if (-1 == h->codecs[DS_RS]->store(h->codecs[DS_RS], map, "RS", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_PD]) { + if (-1 == h->codecs[DS_PD]->store(h->codecs[DS_PD], map, "PD", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_HC]) { + if (-1 == h->codecs[DS_HC]->store(h->codecs[DS_HC], map, "HC", + fd->version)) + return NULL; + mc++; + } + } + if (h->codecs[DS_TM]) { + if (-1 == h->codecs[DS_TM]->store(h->codecs[DS_TM], map, "TM", + fd->version)) + return NULL; + mc++; + } + if (h->codecs[DS_TV]) { + if (-1 == h->codecs[DS_TV]->store(h->codecs[DS_TV], map, "TV", + fd->version)) + return NULL; + mc++; + } + itf8_put_blk(cb, BLOCK_SIZE(map) + itf8_size(mc)); + itf8_put_blk(cb, mc); + BLOCK_APPEND(cb, BLOCK_DATA(map), BLOCK_SIZE(map)); + + /* tag encoding map */ +#if 0 + mp = map; mc = 0; + if (h->tag_encoding_map) { + HashItem *hi; + HashIter *iter = HashTableIterCreate(); + if (!iter) + return NULL; + + while ((hi = HashTableIterNext(h->tag_encoding_map, iter))) { + cram_map *m = hi->data.p; + int sz; + + mp += itf8_put(mp, (hi->key[0]<<16)|(hi->key[1]<<8)|hi->key[2]); + if (-1 == (sz = m->codec->store(m->codec, mp, NULL, fd->version))) + return NULL; + mp += sz; + mc++; + } + + HashTableIterDestroy(iter); + } +#else + mc = 0; + BLOCK_SIZE(map) = 0; + if (c->tags_used) { + khint_t k; + +#define TAG_ID(a) ((#a[0]<<8)+#a[1]) + + for (k = kh_begin(c->tags_used); k != kh_end(c->tags_used); k++) { + int key; + if (!kh_exist(c->tags_used, k)) + continue; + + mc++; + itf8_put_blk(map, kh_key(c->tags_used, k)); + + // use block content id 4 + switch((key = kh_key(c->tags_used, k)) & 0xff) { + case 'Z': case 'H': + // string as byte_array_stop + if (CRAM_MAJOR_VERS(fd->version) == 1) { + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\005" // len + "\t" // stop-byte is also SAM separator + DS_aux_S "\000\000\000", + 7); + } else { + if (key>>8 == TAG_ID(OQ)) + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\002" // len + "\t" // stop-byte is also SAM separator + DS_aux_OQ_S, + 4); + else if (key>>8 == TAG_ID(BQ)) + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\002" // len + "\t" // stop-byte is also SAM separator + DS_aux_BQ_S, + 4); + else if (key>>8 == TAG_ID(BD)) + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\002" // len + "\t" // stop-byte is also SAM separator + DS_aux_BD_S, + 4); + else if (key>>8 == TAG_ID(BI)) + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\002" // len + "\t" // stop-byte is also SAM separator + DS_aux_BI_S, + 4); + else if ((key>>8 == TAG_ID(Q2)) || + (key>>8 == TAG_ID(U2)) || + (key>>8 == TAG_ID(QT)) || + (key>>8 == TAG_ID(CQ))) + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\002" // len + "\t" // stop-byte is also SAM separator + DS_aux_oq_S, + 4); + else if ((key>>8 == TAG_ID(R2)) || + (key>>8 == TAG_ID(E2)) || + (key>>8 == TAG_ID(CS)) || + (key>>8 == TAG_ID(BC)) || + (key>>8 == TAG_ID(RT))) + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\002" // len + "\t" // stop-byte is also SAM separator + DS_aux_os_S, + 4); + else + BLOCK_APPEND(map, + "\005" // BYTE_ARRAY_STOP + "\002" // len + "\t" // stop-byte is also SAM separator + DS_aux_oz_S, + 4); + } + break; + + case 'A': case 'c': case 'C': + // byte array len, 1 byte + BLOCK_APPEND(map, + "\004" // BYTE_ARRAY_LEN + "\011" // length + "\003" // HUFFMAN (len) + "\004" // huffman-len + "\001" // 1 symbol + "\001" // symbol=1 byte value + "\001" // 1 length + "\000" // length=0 + "\001" // EXTERNAL (val) + "\001" // external-len + DS_aux_S,// content-id + 11); + break; + + case 's': case 'S': + // byte array len, 2 byte + BLOCK_APPEND(map, + "\004" // BYTE_ARRAY_LEN + "\011" // length + "\003" // HUFFMAN (len) + "\004" // huffman-len + "\001" // 1 symbol + "\002" // symbol=2 byte value + "\001" // 1 length + "\000" // length=0 + "\001" // EXTERNAL (val) + "\001" // external-len + DS_aux_S,// content-id + 11); + break; + + case 'i': case 'I': case 'f': + // byte array len, 4 byte + BLOCK_APPEND(map, + "\004" // BYTE_ARRAY_LEN + "\011" // length + "\003" // HUFFMAN (len) + "\004" // huffman-len + "\001" // 1 symbol + "\004" // symbol=4 byte value + "\001" // 1 length + "\000" // length=0 + "\001" // EXTERNAL (val) + "\001" // external-len + DS_aux_S,// content-id + 11); + break; + + case 'B': + // Byte array of variable size, but we generate our tag + // byte stream at the wrong stage (during reading and not + // after slice header construction). So we use + // BYTE_ARRAY_LEN with the length codec being external + // too. + if ((key>>8 == TAG_ID(FZ)) || (key>>8 == TAG_ID(ZM))) + BLOCK_APPEND(map, + "\004" // BYTE_ARRAY_LEN + "\006" // length + "\001" // EXTERNAL (len) + "\001" // external-len + DS_aux_FZ_S // content-id + "\001" // EXTERNAL (val) + "\001" // external-len + DS_aux_FZ_S,// content-id + 8); + else + BLOCK_APPEND(map, + "\004" // BYTE_ARRAY_LEN + "\006" // length + "\001" // EXTERNAL (len) + "\001" // external-len + DS_aux_S // content-id + "\001" // EXTERNAL (val) + "\001" // external-len + DS_aux_S,// content-id + 8); + break; + + default: + fprintf(stderr, "Unsupported SAM aux type '%c'\n", + kh_key(c->tags_used, k) & 0xff); + } + //mp += m->codec->store(m->codec, mp, NULL, fd->version); + } + } +#endif + itf8_put_blk(cb, BLOCK_SIZE(map) + itf8_size(mc)); + itf8_put_blk(cb, mc); + BLOCK_APPEND(cb, BLOCK_DATA(map), BLOCK_SIZE(map)); + + if (fd->verbose) + fprintf(stderr, "Wrote compression block header in %d bytes\n", + (int)BLOCK_SIZE(cb)); + + BLOCK_UPLEN(cb); + + cram_free_block(map); + + return cb; +} + + +/* + * Encodes a slice compression header. + * + * Returns cram_block on success + * NULL on failure + */ +cram_block *cram_encode_slice_header(cram_fd *fd, cram_slice *s) { + char *buf; + char *cp; + cram_block *b = cram_new_block(MAPPED_SLICE, 0); + int j; + + if (!b) + return NULL; + + if (NULL == (cp = buf = malloc(16+5*(8+s->hdr->num_blocks)))) { + cram_free_block(b); + return NULL; + } + + cp += itf8_put(cp, s->hdr->ref_seq_id); + cp += itf8_put(cp, s->hdr->ref_seq_start); + cp += itf8_put(cp, s->hdr->ref_seq_span); + cp += itf8_put(cp, s->hdr->num_records); + if (CRAM_MAJOR_VERS(fd->version) == 2) + cp += itf8_put(cp, s->hdr->record_counter); + else if (CRAM_MAJOR_VERS(fd->version) >= 3) + cp += ltf8_put(cp, s->hdr->record_counter); + cp += itf8_put(cp, s->hdr->num_blocks); + cp += itf8_put(cp, s->hdr->num_content_ids); + for (j = 0; j < s->hdr->num_content_ids; j++) { + cp += itf8_put(cp, s->hdr->block_content_ids[j]); + } + if (s->hdr->content_type == MAPPED_SLICE) + cp += itf8_put(cp, s->hdr->ref_base_id); + + if (CRAM_MAJOR_VERS(fd->version) != 1) { + memcpy(cp, s->hdr->md5, 16); cp += 16; + } + + assert(cp-buf <= 16+5*(8+s->hdr->num_blocks)); + + b->data = (unsigned char *)buf; + b->comp_size = b->uncomp_size = cp-buf; + + return b; +} + + +/* + * Encodes a single read. + * + * Returns 0 on success + * -1 on failure + */ +static int cram_encode_slice_read(cram_fd *fd, + cram_container *c, + cram_block_compression_hdr *h, + cram_slice *s, + cram_record *cr, + int *last_pos) { + int r = 0; + int32_t i32; + unsigned char uc; + + //fprintf(stderr, "Encode seq %d, %d/%d FN=%d, %s\n", rec, core->byte, core->bit, cr->nfeature, s->name_ds->str + cr->name); + + //printf("BF=0x%x\n", cr->flags); + // bf = cram_flag_swap[cr->flags]; + i32 = fd->cram_flag_swap[cr->flags & 0xfff]; + r |= h->codecs[DS_BF]->encode(s, h->codecs[DS_BF], (char *)&i32, 1); + + i32 = cr->cram_flags; + r |= h->codecs[DS_CF]->encode(s, h->codecs[DS_CF], (char *)&i32, 1); + + if (CRAM_MAJOR_VERS(fd->version) != 1 && s->hdr->ref_seq_id == -2) + r |= h->codecs[DS_RI]->encode(s, h->codecs[DS_RI], (char *)&cr->ref_id, 1); + + r |= h->codecs[DS_RL]->encode(s, h->codecs[DS_RL], (char *)&cr->len, 1); + + if (c->pos_sorted) { + i32 = cr->apos - *last_pos; + r |= h->codecs[DS_AP]->encode(s, h->codecs[DS_AP], (char *)&i32, 1); + *last_pos = cr->apos; + } else { + i32 = cr->apos; + r |= h->codecs[DS_AP]->encode(s, h->codecs[DS_AP], (char *)&i32, 1); + } + + r |= h->codecs[DS_RG]->encode(s, h->codecs[DS_RG], (char *)&cr->rg, 1); + + if (c->comp_hdr->read_names_included) { + // RN codec: Already stored in block[3]. + } + + if (cr->cram_flags & CRAM_FLAG_DETACHED) { + i32 = cr->mate_flags; + r |= h->codecs[DS_MF]->encode(s, h->codecs[DS_MF], (char *)&i32, 1); + + if (!c->comp_hdr->read_names_included) { + // RN codec: Already stored in block[3]. + } + + r |= h->codecs[DS_NS]->encode(s, h->codecs[DS_NS], + (char *)&cr->mate_ref_id, 1); + + r |= h->codecs[DS_NP]->encode(s, h->codecs[DS_NP], + (char *)&cr->mate_pos, 1); + + r |= h->codecs[DS_TS]->encode(s, h->codecs[DS_TS], + (char *)&cr->tlen, 1); + } else if (cr->cram_flags & CRAM_FLAG_MATE_DOWNSTREAM) { + r |= h->codecs[DS_NF]->encode(s, h->codecs[DS_NF], + (char *)&cr->mate_line, 1); + } + + /* Aux tags */ + if (CRAM_MAJOR_VERS(fd->version) == 1) { + int j; + uc = cr->ntags; + r |= h->codecs[DS_TC]->encode(s, h->codecs[DS_TC], (char *)&uc, 1); + + for (j = 0; j < cr->ntags; j++) { + uint32_t i32 = s->TN[cr->TN_idx + j]; // id + r |= h->codecs[DS_TN]->encode(s, h->codecs[DS_TN], (char *)&i32, 1); + } + } else { + r |= h->codecs[DS_TL]->encode(s, h->codecs[DS_TL], (char *)&cr->TL, 1); + } + + // qual + // QS codec : Already stored in block[2]. + + // features (diffs) + if (!(cr->flags & BAM_FUNMAP)) { + int prev_pos = 0, j; + + r |= h->codecs[DS_FN]->encode(s, h->codecs[DS_FN], + (char *)&cr->nfeature, 1); + for (j = 0; j < cr->nfeature; j++) { + cram_feature *f = &s->features[cr->feature + j]; + + uc = f->X.code; + r |= h->codecs[DS_FC]->encode(s, h->codecs[DS_FC], (char *)&uc, 1); + i32 = f->X.pos - prev_pos; + r |= h->codecs[DS_FP]->encode(s, h->codecs[DS_FP], (char *)&i32, 1); + prev_pos = f->X.pos; + + switch(f->X.code) { + //char *seq; + + case 'X': + //fprintf(stderr, " FC=%c FP=%d base=%d\n", f->X.code, i32, f->X.base); + + uc = f->X.base; + r |= h->codecs[DS_BS]->encode(s, h->codecs[DS_BS], + (char *)&uc, 1); + break; + case 'S': + // Already done +// r |= h->codecs[DS_SC]->encode(s, h->codecs[DS_SC], +// BLOCK_DATA(s->soft_blk) + f->S.seq_idx, +// f->S.len); + +// if (IS_CRAM_3_VERS(fd)) { +// r |= h->codecs[DS_BB]->encode(s, h->codecs[DS_BB], +// BLOCK_DATA(s->seqs_blk) + f->S.seq_idx, +// f->S.len); +// } + break; + case 'I': + //seq = DSTRING_STR(s->seqs_ds) + f->S.seq_idx; + //r |= h->codecs[DS_IN]->encode(s, h->codecs[DS_IN], + // seq, f->S.len); +// if (IS_CRAM_3_VERS(fd)) { +// r |= h->codecs[DS_BB]->encode(s, h->codecs[DS_BB], +// BLOCK_DATA(s->seqs_blk) + f->I.seq_idx, +// f->I.len); +// } + break; + case 'i': + uc = f->i.base; + r |= h->codecs[DS_BA]->encode(s, h->codecs[DS_BA], + (char *)&uc, 1); + //seq = DSTRING_STR(s->seqs_ds) + f->S.seq_idx; + //r |= h->codecs[DS_IN]->encode(s, h->codecs[DS_IN], + // seq, 1); + break; + case 'D': + i32 = f->D.len; + r |= h->codecs[DS_DL]->encode(s, h->codecs[DS_DL], + (char *)&i32, 1); + break; + + case 'B': + // // Used when we try to store a non ACGTN base or an N + // // that aligns against a non ACGTN reference + + uc = f->B.base; + r |= h->codecs[DS_BA]->encode(s, h->codecs[DS_BA], + (char *)&uc, 1); + + // Already added + // uc = f->B.qual; + // r |= h->codecs[DS_QS]->encode(s, h->codecs[DS_QS], + // (char *)&uc, 1); + break; + + case 'b': + // string of bases + r |= h->codecs[DS_BB]->encode(s, h->codecs[DS_BB], + (char *)BLOCK_DATA(s->seqs_blk) + + f->b.seq_idx, + f->b.len); + break; + + case 'Q': + // Already added + // uc = f->B.qual; + // r |= h->codecs[DS_QS]->encode(s, h->codecs[DS_QS], + // (char *)&uc, 1); + break; + + case 'N': + i32 = f->N.len; + r |= h->codecs[DS_RS]->encode(s, h->codecs[DS_RS], + (char *)&i32, 1); + break; + + case 'P': + i32 = f->P.len; + r |= h->codecs[DS_PD]->encode(s, h->codecs[DS_PD], + (char *)&i32, 1); + break; + + case 'H': + i32 = f->H.len; + r |= h->codecs[DS_HC]->encode(s, h->codecs[DS_HC], + (char *)&i32, 1); + break; + + + default: + fprintf(stderr, "unhandled feature code %c\n", + f->X.code); + return -1; + } + } + + r |= h->codecs[DS_MQ]->encode(s, h->codecs[DS_MQ], + (char *)&cr->mqual, 1); + } else { + char *seq = (char *)BLOCK_DATA(s->seqs_blk) + cr->seq; + r |= h->codecs[DS_BA]->encode(s, h->codecs[DS_BA], seq, cr->len); + } + + return r ? -1 : 0; +} + + +/* + * Applies various compression methods to specific blocks, depending on + * known observations of how data series compress. + * + * Returns 0 on success + * -1 on failure + */ +static int cram_compress_slice(cram_fd *fd, cram_slice *s) { + int level = fd->level, i; + int method = 1<<GZIP | 1<<GZIP_RLE, methodF = method; + + /* Compress the CORE Block too, with minimal zlib level */ + if (level > 5 && s->block[0]->uncomp_size > 500) + cram_compress_block(fd, s->block[0], NULL, GZIP, 1); + + if (fd->use_bz2) + method |= 1<<BZIP2; + + if (fd->use_rans) + method |= (1<<RANS0) | (1<<RANS1); + + if (fd->use_lzma) + method |= (1<<LZMA); + + /* Faster method for data series we only need entropy encoding on */ + methodF = method & ~(1<<GZIP | 1<<BZIP2 | 1<<LZMA); + if (level >= 6) + methodF = method; + + + /* Specific compression methods for certain block types */ + if (cram_compress_block(fd, s->block[DS_IN], fd->m[DS_IN], //IN (seq) + method, level)) + return -1; + + if (fd->level == 0) { + /* Do nothing */ + } else if (fd->level == 1) { + if (cram_compress_block(fd, s->block[DS_QS], fd->m[DS_QS], + methodF, 1)) + return -1; + for (i = DS_aux; i <= DS_aux_oz; i++) { + if (s->block[i]) + if (cram_compress_block(fd, s->block[i], fd->m[i], + method, 1)) + return -1; + } + } else if (fd->level < 3) { + if (cram_compress_block(fd, s->block[DS_QS], fd->m[DS_QS], + method, 1)) + return -1; + if (cram_compress_block(fd, s->block[DS_BA], fd->m[DS_BA], + method, 1)) + return -1; + if (s->block[DS_BB]) + if (cram_compress_block(fd, s->block[DS_BB], fd->m[DS_BB], + method, 1)) + return -1; + for (i = DS_aux; i <= DS_aux_oz; i++) { + if (s->block[i]) + if (cram_compress_block(fd, s->block[i], fd->m[i], + method, level)) + return -1; + } + } else { + if (cram_compress_block(fd, s->block[DS_QS], fd->m[DS_QS], + method, level)) + return -1; + if (cram_compress_block(fd, s->block[DS_BA], fd->m[DS_BA], + method, level)) + return -1; + if (s->block[DS_BB]) + if (cram_compress_block(fd, s->block[DS_BB], fd->m[DS_BB], + method, level)) + return -1; + for (i = DS_aux; i <= DS_aux_oz; i++) { + if (s->block[i]) + if (cram_compress_block(fd, s->block[i], fd->m[i], + method, level)) + return -1; + } + } + + // NAME: best is generally xz, bzip2, zlib then rans1 + // It benefits well from a little bit extra compression level. + if (cram_compress_block(fd, s->block[DS_RN], fd->m[DS_RN], + method & ~(1<<RANS0 | 1<<GZIP_RLE), + MIN(9,level))) + return -1; + + // NS shows strong local correlation as rearrangements are localised + if (s->block[DS_NS] != s->block[0]) + if (cram_compress_block(fd, s->block[DS_NS], fd->m[DS_NS], + method, level)) + return -1; + + + /* + * Minimal compression of any block still uncompressed, bar CORE + */ + { + int i; + for (i = 1; i < DS_END; i++) { + if (!s->block[i] || s->block[i] == s->block[0]) + continue; + + // fast methods only + if (s->block[i]->method == RAW) { + cram_compress_block(fd, s->block[i], fd->m[i], + methodF, level); + } + } + } + + return 0; +} + +/* + * Encodes a single slice from a container + * + * Returns 0 on success + * -1 on failure + */ +static int cram_encode_slice(cram_fd *fd, cram_container *c, + cram_block_compression_hdr *h, cram_slice *s) { + int rec, r = 0, last_pos; + int embed_ref; + enum cram_DS_ID id; + + embed_ref = fd->embed_ref && s->hdr->ref_seq_id != -1 ? 1 : 0; + + /* + * Slice external blocks: + * ID 0 => base calls (insertions, soft-clip) + * ID 1 => qualities + * ID 2 => names + * ID 3 => TS (insert size), NP (next frag) + * ID 4 => tag values + * ID 6 => tag IDs (TN), if CRAM_V1.0 + * ID 7 => TD tag dictionary, if !CRAM_V1.0 + */ + + /* Create cram slice header */ + s->hdr->ref_base_id = embed_ref ? DS_ref : -1; + s->hdr->record_counter = c->num_records + c->record_counter; + c->num_records += s->hdr->num_records; + + s->block = calloc(DS_END, sizeof(s->block[0])); + s->hdr->block_content_ids = malloc(DS_END * sizeof(int32_t)); + if (!s->block || !s->hdr->block_content_ids) + return -1; + + // Create first fixed blocks, always external. + // CORE + if (!(s->block[0] = cram_new_block(CORE, 0))) + return -1; + + // TN block for CRAM v1 + if (CRAM_MAJOR_VERS(fd->version) == 1) { + if (h->codecs[DS_TN]->codec == E_EXTERNAL) { + if (!(s->block[DS_TN] = cram_new_block(EXTERNAL,DS_TN))) return -1; + h->codecs[DS_TN]->external.content_id = DS_TN; + } else { + s->block[DS_TN] = s->block[0]; + } + s->block[DS_TN] = s->block[DS_TN]; + } + + // Embedded reference + if (embed_ref) { + if (!(s->block[DS_ref] = cram_new_block(EXTERNAL, DS_ref))) + return -1; + s->ref_id = DS_ref; // needed? + BLOCK_APPEND(s->block[DS_ref], + c->ref + c->first_base - c->ref_start, + c->last_base - c->first_base + 1); + } + + /* + * All the data-series blocks if appropriate. + */ + for (id = DS_BF; id < DS_TN; id++) { + if (h->codecs[id] && (h->codecs[id]->codec == E_EXTERNAL || + h->codecs[id]->codec == E_BYTE_ARRAY_STOP || + h->codecs[id]->codec == E_BYTE_ARRAY_LEN)) { + switch (h->codecs[id]->codec) { + case E_EXTERNAL: + if (!(s->block[id] = cram_new_block(EXTERNAL, id))) + return -1; + h->codecs[id]->external.content_id = id; + break; + + case E_BYTE_ARRAY_STOP: + if (!(s->block[id] = cram_new_block(EXTERNAL, id))) + return -1; + h->codecs[id]->byte_array_stop.content_id = id; + break; + + case E_BYTE_ARRAY_LEN: { + cram_codec *cc; + + cc = h->codecs[id]->e_byte_array_len.len_codec; + if (cc->codec == E_EXTERNAL) { + int eid = cc->external.content_id; + if (!(s->block[eid] = cram_new_block(EXTERNAL, eid))) + return -1; + cc->external.content_id = eid; + cc->out = s->block[eid]; + } + + cc = h->codecs[id]->e_byte_array_len.val_codec; + if (cc->codec == E_EXTERNAL) { + int eid = cc->external.content_id; + if (!s->block[eid]) + if (!(s->block[eid] = cram_new_block(EXTERNAL, eid))) + return -1; + cc->external.content_id = eid; + cc->out = s->block[eid]; + } + break; + } + default: + break; + } + } else { + if (!(id == DS_BB && !h->codecs[DS_BB])) + s->block[id] = s->block[0]; + } + if (h->codecs[id]) + h->codecs[id]->out = s->block[id]; + } + + /* Encode reads */ + last_pos = s->hdr->ref_seq_start; + for (rec = 0; rec < s->hdr->num_records; rec++) { + cram_record *cr = &s->crecs[rec]; + if (cram_encode_slice_read(fd, c, h, s, cr, &last_pos) == -1) + return -1; + } + + s->block[0]->uncomp_size = s->block[0]->byte + (s->block[0]->bit < 7); + s->block[0]->comp_size = s->block[0]->uncomp_size; + + // Make sure the fixed blocks point to the correct sources + s->block[DS_IN] = s->base_blk; s->base_blk = NULL; + s->block[DS_QS] = s->qual_blk; s->qual_blk = NULL; + s->block[DS_RN] = s->name_blk; s->name_blk = NULL; + s->block[DS_SC] = s->soft_blk; s->soft_blk = NULL; + s->block[DS_aux]= s->aux_blk; s->aux_blk = NULL; + s->block[DS_aux_OQ]= s->aux_OQ_blk; s->aux_OQ_blk = NULL; + s->block[DS_aux_BQ]= s->aux_BQ_blk; s->aux_BQ_blk = NULL; + s->block[DS_aux_BD]= s->aux_BD_blk; s->aux_BD_blk = NULL; + s->block[DS_aux_BI]= s->aux_BI_blk; s->aux_BI_blk = NULL; + s->block[DS_aux_FZ]= s->aux_FZ_blk; s->aux_FZ_blk = NULL; + s->block[DS_aux_oq]= s->aux_oq_blk; s->aux_oq_blk = NULL; + s->block[DS_aux_os]= s->aux_os_blk; s->aux_os_blk = NULL; + s->block[DS_aux_oz]= s->aux_oz_blk; s->aux_oz_blk = NULL; + + // Ensure block sizes are up to date. + for (id = 1; id < DS_END; id++) { + if (!s->block[id] || s->block[id] == s->block[0]) + continue; + + if (s->block[id]->uncomp_size == 0) + BLOCK_UPLEN(s->block[id]); + } + + // Compress it all + if (cram_compress_slice(fd, s) == -1) + return -1; + + // Collapse empty blocks and create hdr_block + { + int i, j; + for (i = j = 1; i < DS_END; i++) { + if (!s->block[i] || s->block[i] == s->block[0]) + continue; + if (s->block[i]->uncomp_size == 0) { + cram_free_block(s->block[i]); + s->block[i] = NULL; + continue; + } + s->block[j] = s->block[i]; + s->hdr->block_content_ids[j-1] = s->block[i]->content_id; + j++; + } + s->hdr->num_content_ids = j-1; + s->hdr->num_blocks = j; + + if (!(s->hdr_block = cram_encode_slice_header(fd, s))) + return -1; + } + + return r ? -1 : 0; +} + +/* + * Encodes all slices in a container into blocks. + * Returns 0 on success + * -1 on failure + */ +int cram_encode_container(cram_fd *fd, cram_container *c) { + int i, j, slice_offset; + cram_block_compression_hdr *h = c->comp_hdr; + cram_block *c_hdr; + int multi_ref = 0; + int r1, r2, sn, nref; + spare_bams *spares; + + /* Cache references up-front if we have unsorted access patterns */ + pthread_mutex_lock(&fd->ref_lock); + nref = fd->refs->nref; + pthread_mutex_unlock(&fd->ref_lock); + + if (!fd->no_ref && c->refs_used) { + for (i = 0; i < nref; i++) { + if (c->refs_used[i]) + cram_get_ref(fd, i, 1, 0); + } + } + + /* To create M5 strings */ + /* Fetch reference sequence */ + if (!fd->no_ref) { + bam_seq_t *b = c->bams[0]; + char *ref; + + ref = cram_get_ref(fd, bam_ref(b), 1, 0); + if (!ref && bam_ref(b) >= 0) { + fprintf(stderr, "Failed to load reference #%d\n", bam_ref(b)); + return -1; + } + if ((c->ref_id = bam_ref(b)) >= 0) { + c->ref_seq_id = c->ref_id; + c->ref = fd->refs->ref_id[c->ref_seq_id]->seq; + c->ref_start = 1; + c->ref_end = fd->refs->ref_id[c->ref_seq_id]->length; + } else { + c->ref_seq_id = c->ref_id; // FIXME remove one var! + } + } else { + c->ref_id = bam_ref(c->bams[0]); + cram_ref_incr(fd->refs, c->ref_id); + c->ref_seq_id = c->ref_id; + } + + /* Turn bams into cram_records and gather basic stats */ + for (r1 = sn = 0; r1 < c->curr_c_rec; sn++) { + cram_slice *s = c->slices[sn]; + int first_base = INT_MAX, last_base = INT_MIN; + + assert(sn < c->curr_slice); + + /* FIXME: we could create our slice objects here too instead of + * in cram_put_bam_seq. It's more natural here and also this is + * bit is threaded so it's less work in the main thread. + */ + + for (r2 = 0; r1 < c->curr_c_rec && r2 < c->max_rec; r1++, r2++) { + cram_record *cr = &s->crecs[r2]; + bam_seq_t *b = c->bams[r1]; + + /* If multi-ref we need to cope with changing reference per seq */ + if (c->multi_seq && !fd->no_ref) { + if (bam_ref(b) != c->ref_seq_id && bam_ref(b) >= 0) { + if (c->ref_seq_id >= 0) + cram_ref_decr(fd->refs, c->ref_seq_id); + + if (!cram_get_ref(fd, bam_ref(b), 1, 0)) { + fprintf(stderr, "Failed to load reference #%d\n", + bam_ref(b)); + return -1; + } + + c->ref_seq_id = bam_ref(b); // overwritten later by -2 + assert(fd->refs->ref_id[c->ref_seq_id]->seq); + c->ref = fd->refs->ref_id[c->ref_seq_id]->seq; + c->ref_start = 1; + c->ref_end = fd->refs->ref_id[c->ref_seq_id]->length; + } + } + + process_one_read(fd, c, s, cr, b, r2); + + if (first_base > cr->apos) + first_base = cr->apos; + + if (last_base < cr->aend) + last_base = cr->aend; + } + + if (c->multi_seq) { + s->hdr->ref_seq_id = -2; + s->hdr->ref_seq_start = 0; + s->hdr->ref_seq_span = 0; + } else { + s->hdr->ref_seq_id = c->ref_id; + s->hdr->ref_seq_start = first_base; + s->hdr->ref_seq_span = last_base - first_base + 1; + } + s->hdr->num_records = r2; + } + + if (c->multi_seq && !fd->no_ref) { + if (c->ref_seq_id >= 0) + cram_ref_decr(fd->refs, c->ref_seq_id); + } + + /* Link our bams[] array onto the spare bam list for reuse */ + spares = malloc(sizeof(*spares)); + pthread_mutex_lock(&fd->bam_list_lock); + spares->bams = c->bams; + spares->next = fd->bl; + fd->bl = spares; + pthread_mutex_unlock(&fd->bam_list_lock); + c->bams = NULL; + + /* Detect if a multi-seq container */ + cram_stats_encoding(fd, c->stats[DS_RI]); + multi_ref = c->stats[DS_RI]->nvals > 1; + + if (multi_ref) { + if (fd->verbose) + fprintf(stderr, "Multi-ref container\n"); + c->ref_seq_id = -2; + c->ref_seq_start = 0; + c->ref_seq_span = 0; + } + + + /* Compute MD5s */ + for (i = 0; i < c->curr_slice; i++) { + cram_slice *s = c->slices[i]; + + if (CRAM_MAJOR_VERS(fd->version) != 1) { + if (s->hdr->ref_seq_id >= 0 && c->multi_seq == 0 && !fd->no_ref) { + MD5_CTX md5; + MD5_Init(&md5); + MD5_Update(&md5, + c->ref + s->hdr->ref_seq_start - c->ref_start, + s->hdr->ref_seq_span); + MD5_Final(s->hdr->md5, &md5); + } else { + memset(s->hdr->md5, 0, 16); + } + } + } + + c->num_records = 0; + c->num_blocks = 0; + c->length = 0; + + //fprintf(stderr, "=== BF ===\n"); + h->codecs[DS_BF] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_BF]), + c->stats[DS_BF], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== CF ===\n"); + h->codecs[DS_CF] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_CF]), + c->stats[DS_CF], E_INT, NULL, + fd->version); +// fprintf(stderr, "=== RN ===\n"); +// h->codecs[DS_RN] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_RN]), +// c->stats[DS_RN], E_BYTE_ARRAY, NULL, +// fd->version); + + //fprintf(stderr, "=== AP ===\n"); + if (c->pos_sorted) { + h->codecs[DS_AP] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_AP]), + c->stats[DS_AP], E_INT, NULL, + fd->version); + } else { + int p[2] = {0, c->max_apos}; + h->codecs[DS_AP] = cram_encoder_init(E_BETA, NULL, E_INT, p, + fd->version); + } + + //fprintf(stderr, "=== RG ===\n"); + h->codecs[DS_RG] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_RG]), + c->stats[DS_RG], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== MQ ===\n"); + h->codecs[DS_MQ] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_MQ]), + c->stats[DS_MQ], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== NS ===\n"); + h->codecs[DS_NS] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_NS]), + c->stats[DS_NS], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== MF ===\n"); + h->codecs[DS_MF] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_MF]), + c->stats[DS_MF], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== TS ===\n"); + h->codecs[DS_TS] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_TS]), + c->stats[DS_TS], E_INT, NULL, + fd->version); + //fprintf(stderr, "=== NP ===\n"); + h->codecs[DS_NP] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_NP]), + c->stats[DS_NP], E_INT, NULL, + fd->version); + //fprintf(stderr, "=== NF ===\n"); + h->codecs[DS_NF] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_NF]), + c->stats[DS_NF], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== RL ===\n"); + h->codecs[DS_RL] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_RL]), + c->stats[DS_RL], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== FN ===\n"); + h->codecs[DS_FN] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_FN]), + c->stats[DS_FN], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== FC ===\n"); + h->codecs[DS_FC] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_FC]), + c->stats[DS_FC], E_BYTE, NULL, + fd->version); + + //fprintf(stderr, "=== FP ===\n"); + h->codecs[DS_FP] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_FP]), + c->stats[DS_FP], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== DL ===\n"); + h->codecs[DS_DL] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_DL]), + c->stats[DS_DL], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== BA ===\n"); + h->codecs[DS_BA] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_BA]), + c->stats[DS_BA], E_BYTE, NULL, + fd->version); + + if (CRAM_MAJOR_VERS(fd->version) >= 3) { + cram_byte_array_len_encoder e; + + e.len_encoding = E_EXTERNAL; + e.len_dat = (void *)DS_BB_len; + //e.len_dat = (void *)DS_BB; + + e.val_encoding = E_EXTERNAL; + e.val_dat = (void *)DS_BB; + + h->codecs[DS_BB] = cram_encoder_init(E_BYTE_ARRAY_LEN, NULL, + E_BYTE_ARRAY, (void *)&e, + fd->version); + } else { + h->codecs[DS_BB] = NULL; + } + + //fprintf(stderr, "=== BS ===\n"); + h->codecs[DS_BS] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_BS]), + c->stats[DS_BS], E_BYTE, NULL, + fd->version); + + if (CRAM_MAJOR_VERS(fd->version) == 1) { + h->codecs[DS_TL] = NULL; + h->codecs[DS_RI] = NULL; + h->codecs[DS_RS] = NULL; + h->codecs[DS_PD] = NULL; + h->codecs[DS_HC] = NULL; + h->codecs[DS_SC] = NULL; + + //fprintf(stderr, "=== TC ===\n"); + h->codecs[DS_TC] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_TC]), + c->stats[DS_TC], E_BYTE, NULL, + fd->version); + + //fprintf(stderr, "=== TN ===\n"); + h->codecs[DS_TN] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_TN]), + c->stats[DS_TN], E_INT, NULL, + fd->version); + } else { + h->codecs[DS_TC] = NULL; + h->codecs[DS_TN] = NULL; + + //fprintf(stderr, "=== TL ===\n"); + h->codecs[DS_TL] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_TL]), + c->stats[DS_TL], E_INT, NULL, + fd->version); + + + //fprintf(stderr, "=== RI ===\n"); + h->codecs[DS_RI] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_RI]), + c->stats[DS_RI], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== RS ===\n"); + h->codecs[DS_RS] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_RS]), + c->stats[DS_RS], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== PD ===\n"); + h->codecs[DS_PD] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_PD]), + c->stats[DS_PD], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== HC ===\n"); + h->codecs[DS_HC] = cram_encoder_init(cram_stats_encoding(fd, c->stats[DS_HC]), + c->stats[DS_HC], E_INT, NULL, + fd->version); + + //fprintf(stderr, "=== SC ===\n"); + if (1) { + int i2[2] = {0, DS_SC}; + + h->codecs[DS_SC] = cram_encoder_init(E_BYTE_ARRAY_STOP, NULL, + E_BYTE_ARRAY, (void *)i2, + fd->version); + } else { + // Appears to be no practical benefit to using this method, + // but it may work better if we start mixing SC, IN and BB + // elements into the same external block. + cram_byte_array_len_encoder e; + + e.len_encoding = E_EXTERNAL; + e.len_dat = (void *)DS_SC_len; + + e.val_encoding = E_EXTERNAL; + e.val_dat = (void *)DS_SC; + + h->codecs[DS_SC] = cram_encoder_init(E_BYTE_ARRAY_LEN, NULL, + E_BYTE_ARRAY, (void *)&e, + fd->version); + } + } + + //fprintf(stderr, "=== IN ===\n"); + { + int i2[2] = {0, DS_IN}; + h->codecs[DS_IN] = cram_encoder_init(E_BYTE_ARRAY_STOP, NULL, + E_BYTE_ARRAY, (void *)i2, + fd->version); + } + + h->codecs[DS_QS] = cram_encoder_init(E_EXTERNAL, NULL, E_BYTE, + (void *)DS_QS, + fd->version); + { + int i2[2] = {0, DS_RN}; + h->codecs[DS_RN] = cram_encoder_init(E_BYTE_ARRAY_STOP, NULL, + E_BYTE_ARRAY, (void *)i2, + fd->version); + } + + + /* Encode slices */ + for (i = 0; i < c->curr_slice; i++) { + if (fd->verbose) + fprintf(stderr, "Encode slice %d\n", i); + if (cram_encode_slice(fd, c, h, c->slices[i]) != 0) + return -1; + } + + /* Create compression header */ + { + h->ref_seq_id = c->ref_seq_id; + h->ref_seq_start = c->ref_seq_start; + h->ref_seq_span = c->ref_seq_span; + h->num_records = c->num_records; + + h->mapped_qs_included = 0; // fixme + h->unmapped_qs_included = 0; // fixme + // h->... fixme + memcpy(h->substitution_matrix, CRAM_SUBST_MATRIX, 20); + + if (!(c_hdr = cram_encode_compression_header(fd, c, h))) + return -1; + } + + /* Compute landmarks */ + /* Fill out slice landmarks */ + c->num_landmarks = c->curr_slice; + c->landmark = malloc(c->num_landmarks * sizeof(*c->landmark)); + if (!c->landmark) + return -1; + + /* + * Slice offset starts after the first block, so we need to simulate + * writing it to work out the correct offset + */ + { + slice_offset = c_hdr->method == RAW + ? c_hdr->uncomp_size + : c_hdr->comp_size; + slice_offset += 2 + 4*(CRAM_MAJOR_VERS(fd->version) >= 3) + + itf8_size(c_hdr->content_id) + + itf8_size(c_hdr->comp_size) + + itf8_size(c_hdr->uncomp_size); + } + + c->ref_seq_id = c->slices[0]->hdr->ref_seq_id; + c->ref_seq_start = c->slices[0]->hdr->ref_seq_start; + c->ref_seq_span = c->slices[0]->hdr->ref_seq_span; + for (i = 0; i < c->curr_slice; i++) { + cram_slice *s = c->slices[i]; + + c->num_blocks += s->hdr->num_blocks + 2; + c->landmark[i] = slice_offset; + + if (s->hdr->ref_seq_start + s->hdr->ref_seq_span > + c->ref_seq_start + c->ref_seq_span) { + c->ref_seq_span = s->hdr->ref_seq_start + s->hdr->ref_seq_span + - c->ref_seq_start; + } + + slice_offset += s->hdr_block->method == RAW + ? s->hdr_block->uncomp_size + : s->hdr_block->comp_size; + + slice_offset += 2 + 4*(CRAM_MAJOR_VERS(fd->version) >= 3) + + itf8_size(s->hdr_block->content_id) + + itf8_size(s->hdr_block->comp_size) + + itf8_size(s->hdr_block->uncomp_size); + + for (j = 0; j < s->hdr->num_blocks; j++) { + slice_offset += 2 + 4*(CRAM_MAJOR_VERS(fd->version) >= 3) + + itf8_size(s->block[j]->content_id) + + itf8_size(s->block[j]->comp_size) + + itf8_size(s->block[j]->uncomp_size); + + slice_offset += s->block[j]->method == RAW + ? s->block[j]->uncomp_size + : s->block[j]->comp_size; + } + } + c->length += slice_offset; // just past the final slice + + c->comp_hdr_block = c_hdr; + + if (c->ref_seq_id >= 0) { + cram_ref_decr(fd->refs, c->ref_seq_id); + } + + /* Cache references up-front if we have unsorted access patterns */ + if (!fd->no_ref && c->refs_used) { + for (i = 0; i < fd->refs->nref; i++) { + if (c->refs_used[i]) + cram_ref_decr(fd->refs, i); + } + } + + return 0; +} + + +/* + * Adds a feature code to a read within a slice. For purposes of minimising + * memory allocations and fragmentation we have one array of features for all + * reads within the slice. We return the index into this array for this new + * feature. + * + * Returns feature index on success + * -1 on failure. + */ +static int cram_add_feature(cram_container *c, cram_slice *s, + cram_record *r, cram_feature *f) { + if (s->nfeatures >= s->afeatures) { + s->afeatures = s->afeatures ? s->afeatures*2 : 1024; + s->features = realloc(s->features, s->afeatures*sizeof(*s->features)); + if (!s->features) + return -1; + } + + if (!r->nfeature++) { + r->feature = s->nfeatures; + cram_stats_add(c->stats[DS_FP], f->X.pos); + } else { + cram_stats_add(c->stats[DS_FP], + f->X.pos - s->features[r->feature + r->nfeature-2].X.pos); + } + cram_stats_add(c->stats[DS_FC], f->X.code); + + s->features[s->nfeatures++] = *f; + + return 0; +} + +static int cram_add_substitution(cram_fd *fd, cram_container *c, + cram_slice *s, cram_record *r, + int pos, char base, char qual, char ref) { + cram_feature f; + + // seq=ACGTN vs ref=ACGT or seq=ACGT vs ref=ACGTN + if (fd->L2[(uc)base]<4 || (fd->L2[(uc)base]<5 && fd->L2[(uc)ref]<4)) { + f.X.pos = pos+1; + f.X.code = 'X'; + f.X.base = fd->cram_sub_matrix[ref&0x1f][base&0x1f]; + cram_stats_add(c->stats[DS_BS], f.X.base); + } else { + f.B.pos = pos+1; + f.B.code = 'B'; + f.B.base = base; + f.B.qual = qual; + cram_stats_add(c->stats[DS_BA], f.B.base); + cram_stats_add(c->stats[DS_QS], f.B.qual); + BLOCK_APPEND_CHAR(s->qual_blk, qual); + } + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_bases(cram_fd *fd, cram_container *c, + cram_slice *s, cram_record *r, + int pos, int len, char *base) { + cram_feature f; + + f.b.pos = pos+1; + f.b.code = 'b'; + f.b.seq_idx = base - (char *)BLOCK_DATA(s->seqs_blk); + f.b.len = len; + + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_base(cram_fd *fd, cram_container *c, + cram_slice *s, cram_record *r, + int pos, char base, char qual) { + cram_feature f; + f.B.pos = pos+1; + f.B.code = 'B'; + f.B.base = base; + f.B.qual = qual; + cram_stats_add(c->stats[DS_BA], base); + cram_stats_add(c->stats[DS_QS], qual); + BLOCK_APPEND_CHAR(s->qual_blk, qual); + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_quality(cram_fd *fd, cram_container *c, + cram_slice *s, cram_record *r, + int pos, char qual) { + cram_feature f; + f.Q.pos = pos+1; + f.Q.code = 'Q'; + f.Q.qual = qual; + cram_stats_add(c->stats[DS_QS], qual); + BLOCK_APPEND_CHAR(s->qual_blk, qual); + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_deletion(cram_container *c, cram_slice *s, cram_record *r, + int pos, int len, char *base) { + cram_feature f; + f.D.pos = pos+1; + f.D.code = 'D'; + f.D.len = len; + cram_stats_add(c->stats[DS_DL], len); + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_softclip(cram_container *c, cram_slice *s, cram_record *r, + int pos, int len, char *base, int version) { + cram_feature f; + f.S.pos = pos+1; + f.S.code = 'S'; + f.S.len = len; + switch (CRAM_MAJOR_VERS(version)) { + case 1: + f.S.seq_idx = BLOCK_SIZE(s->base_blk); + BLOCK_APPEND(s->base_blk, base, len); + BLOCK_APPEND_CHAR(s->base_blk, '\0'); + break; + + case 2: + default: + f.S.seq_idx = BLOCK_SIZE(s->soft_blk); + if (base) { + BLOCK_APPEND(s->soft_blk, base, len); + } else { + int i; + for (i = 0; i < len; i++) + BLOCK_APPEND_CHAR(s->soft_blk, 'N'); + } + BLOCK_APPEND_CHAR(s->soft_blk, '\0'); + break; + +// default: +// // v3.0 onwards uses BB data-series +// f.S.seq_idx = BLOCK_SIZE(s->soft_blk); + } + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_hardclip(cram_container *c, cram_slice *s, cram_record *r, + int pos, int len, char *base) { + cram_feature f; + f.S.pos = pos+1; + f.S.code = 'H'; + f.S.len = len; + cram_stats_add(c->stats[DS_HC], len); + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_skip(cram_container *c, cram_slice *s, cram_record *r, + int pos, int len, char *base) { + cram_feature f; + f.S.pos = pos+1; + f.S.code = 'N'; + f.S.len = len; + cram_stats_add(c->stats[DS_RS], len); + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_pad(cram_container *c, cram_slice *s, cram_record *r, + int pos, int len, char *base) { + cram_feature f; + f.S.pos = pos+1; + f.S.code = 'P'; + f.S.len = len; + cram_stats_add(c->stats[DS_PD], len); + return cram_add_feature(c, s, r, &f); +} + +static int cram_add_insertion(cram_container *c, cram_slice *s, cram_record *r, + int pos, int len, char *base) { + cram_feature f; + f.I.pos = pos+1; + if (len == 1) { + char b = base ? *base : 'N'; + f.i.code = 'i'; + f.i.base = b; + cram_stats_add(c->stats[DS_BA], b); + } else { + f.I.code = 'I'; + f.I.len = len; + f.S.seq_idx = BLOCK_SIZE(s->base_blk); + if (base) { + BLOCK_APPEND(s->base_blk, base, len); + } else { + int i; + for (i = 0; i < len; i++) + BLOCK_APPEND_CHAR(s->base_blk, 'N'); + } + BLOCK_APPEND_CHAR(s->base_blk, '\0'); + } + return cram_add_feature(c, s, r, &f); +} + +/* + * Encodes auxiliary data. + * Returns the read-group parsed out of the BAM aux fields on success + * NULL on failure or no rg present (FIXME) + */ +static char *cram_encode_aux_1_0(cram_fd *fd, bam_seq_t *b, cram_container *c, + cram_slice *s, cram_record *cr) { + char *aux, *tmp, *rg = NULL; + int aux_size = bam_blk_size(b) - + ((char *)bam_aux(b) - (char *)&bam_ref(b)); + + /* Worst case is 1 nul char on every ??:Z: string, so +33% */ + BLOCK_GROW(s->aux_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_blk); + + aux = (char *)bam_aux(b); + cr->TN_idx = s->nTN; + + while (aux[0] != 0) { + int32_t i32; + int r; + + if (aux[0] == 'R' && aux[1] == 'G' && aux[2] == 'Z') { + rg = &aux[3]; + while (*aux++); + continue; + } + if (aux[0] == 'M' && aux[1] == 'D' && aux[2] == 'Z') { + while (*aux++); + continue; + } + if (aux[0] == 'N' && aux[1] == 'M') { + switch(aux[2]) { + case 'A': case 'C': case 'c': aux+=4; break; + case 'I': case 'i': case 'f': aux+=7; break; + default: + fprintf(stderr, "Unhandled type code for NM tag\n"); + return NULL; + } + continue; + } + + cr->ntags++; + + i32 = (aux[0]<<16) | (aux[1]<<8) | aux[2]; + kh_put(s_i2i, c->tags_used, i32, &r); + if (-1 == r) + return NULL; + + if (s->nTN >= s->aTN) { + s->aTN = s->aTN ? s->aTN*2 : 1024; + if (!(s->TN = realloc(s->TN, s->aTN * sizeof(*s->TN)))) + return NULL; + } + s->TN[s->nTN++] = i32; + cram_stats_add(c->stats[DS_TN], i32); + + switch(aux[2]) { + case 'A': case 'C': case 'c': + aux+=3; //*tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + *tmp++=*aux++; + break; + + case 'S': case 's': + aux+=3; //*tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + *tmp++=*aux++; *tmp++=*aux++; + break; + + case 'I': case 'i': case 'f': + aux+=3; //*tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + break; + + case 'd': + aux+=3; //*tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + break; + + case 'Z': case 'H': + aux+=3; //*tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; // stop byte + break; + + case 'B': { + int type = aux[3], blen; + uint32_t count = (uint32_t)((((unsigned char *)aux)[4]<< 0) + + (((unsigned char *)aux)[5]<< 8) + + (((unsigned char *)aux)[6]<<16) + + (((unsigned char *)aux)[7]<<24)); + // skip TN field + aux+=3; //*tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + + // We use BYTE_ARRAY_LEN with external length, so store that first + switch (type) { + case 'c': case 'C': + blen = count; + break; + case 's': case 'S': + blen = 2*count; + break; + case 'i': case 'I': case 'f': + blen = 4*count; + break; + default: + fprintf(stderr, "Unknown sub-type '%c' for aux type 'B'\n", + type); + return NULL; + + } + + tmp += itf8_put(tmp, blen+5); + + *tmp++=*aux++; // sub-type & length + *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + + // The tag data itself + memcpy(tmp, aux, blen); tmp += blen; aux += blen; + + //cram_stats_add(c->aux_B_stats, blen); + break; + } + default: + fprintf(stderr, "Unknown aux type '%c'\n", aux[2]); + return NULL; + } + } + cram_stats_add(c->stats[DS_TC], cr->ntags); + + cr->aux = BLOCK_SIZE(s->aux_blk); + cr->aux_size = (uc *)tmp - (BLOCK_DATA(s->aux_blk) + cr->aux); + BLOCK_SIZE(s->aux_blk) = (uc *)tmp - BLOCK_DATA(s->aux_blk); + assert(s->aux_blk->byte <= s->aux_blk->alloc); + + return rg; +} + +/* + * Encodes auxiliary data. Largely duplicated from above, but done so to + * keep it simple and avoid a myriad of version ifs. + * + * Returns the read-group parsed out of the BAM aux fields on success + * NULL on failure or no rg present (FIXME) + */ +static char *cram_encode_aux(cram_fd *fd, bam_seq_t *b, cram_container *c, + cram_slice *s, cram_record *cr) { + char *aux, *orig, *tmp, *rg = NULL; + int aux_size = bam_get_l_aux(b); + cram_block *td_b = c->comp_hdr->TD_blk; + int TD_blk_size = BLOCK_SIZE(td_b), new; + char *key; + khint_t k; + + + /* Worst case is 1 nul char on every ??:Z: string, so +33% */ + BLOCK_GROW(s->aux_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_blk); + + + orig = aux = (char *)bam_aux(b); + + // Copy aux keys to td_b and aux values to s->aux_blk + while (aux - orig < aux_size && aux[0] != 0) { + uint32_t i32; + int r; + + if (aux[0] == 'R' && aux[1] == 'G' && aux[2] == 'Z') { + rg = &aux[3]; + while (*aux++); + continue; + } + if (aux[0] == 'M' && aux[1] == 'D' && aux[2] == 'Z') { + while (*aux++); + continue; + } + if (aux[0] == 'N' && aux[1] == 'M') { + switch(aux[2]) { + case 'A': case 'C': case 'c': aux+=4; break; + case 'S': case 's': aux+=5; break; + case 'I': case 'i': case 'f': aux+=7; break; + default: + fprintf(stderr, "Unhandled type code for NM tag\n"); + return NULL; + } + continue; + } + + BLOCK_APPEND(td_b, aux, 3); + + i32 = (aux[0]<<16) | (aux[1]<<8) | aux[2]; + kh_put(s_i2i, c->tags_used, i32, &r); + if (-1 == r) + return NULL; + + // BQ:Z + if (aux[0] == 'B' && aux[1] == 'Q' && aux[2] == 'Z') { + char *tmp; + if (!s->aux_BQ_blk) + if (!(s->aux_BQ_blk = cram_new_block(EXTERNAL, DS_aux_BQ))) + return NULL; + BLOCK_GROW(s->aux_BQ_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_BQ_blk); + aux += 3; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; + BLOCK_SIZE(s->aux_BQ_blk) = (uc *)tmp - BLOCK_DATA(s->aux_BQ_blk); + continue; + } + + // BD:Z + if (aux[0] == 'B' && aux[1]=='D' && aux[2] == 'Z') { + char *tmp; + if (!s->aux_BD_blk) + if (!(s->aux_BD_blk = cram_new_block(EXTERNAL, DS_aux_BD))) + return NULL; + BLOCK_GROW(s->aux_BD_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_BD_blk); + aux += 3; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; + BLOCK_SIZE(s->aux_BD_blk) = (uc *)tmp - BLOCK_DATA(s->aux_BD_blk); + continue; + } + + // BI:Z + if (aux[0] == 'B' && aux[1]=='I' && aux[2] == 'Z') { + char *tmp; + if (!s->aux_BI_blk) + if (!(s->aux_BI_blk = cram_new_block(EXTERNAL, DS_aux_BI))) + return NULL; + BLOCK_GROW(s->aux_BI_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_BI_blk); + aux += 3; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; + BLOCK_SIZE(s->aux_BI_blk) = (uc *)tmp - BLOCK_DATA(s->aux_BI_blk); + continue; + } + + // OQ:Z: + if (aux[0] == 'O' && aux[1] == 'Q' && aux[2] == 'Z') { + char *tmp; + if (!s->aux_OQ_blk) + if (!(s->aux_OQ_blk = cram_new_block(EXTERNAL, DS_aux_OQ))) + return NULL; + BLOCK_GROW(s->aux_OQ_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_OQ_blk); + aux += 3; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; + BLOCK_SIZE(s->aux_OQ_blk) = (uc *)tmp - BLOCK_DATA(s->aux_OQ_blk); + continue; + } + + // FZ:B or ZM:B + if ((aux[0] == 'F' && aux[1] == 'Z' && aux[2] == 'B') || + (aux[0] == 'Z' && aux[1] == 'M' && aux[2] == 'B')) { + int type = aux[3], blen; + uint32_t count = (uint32_t)((((unsigned char *)aux)[4]<< 0) + + (((unsigned char *)aux)[5]<< 8) + + (((unsigned char *)aux)[6]<<16) + + (((unsigned char *)aux)[7]<<24)); + char *tmp; + if (!s->aux_FZ_blk) + if (!(s->aux_FZ_blk = cram_new_block(EXTERNAL, DS_aux_FZ))) + return NULL; + BLOCK_GROW(s->aux_FZ_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_FZ_blk); + + // skip TN field + aux+=3; + + // We use BYTE_ARRAY_LEN with external length, so store that first + switch (type) { + case 'c': case 'C': + blen = count; + break; + case 's': case 'S': + blen = 2*count; + break; + case 'i': case 'I': case 'f': + blen = 4*count; + break; + default: + fprintf(stderr, "Unknown sub-type '%c' for aux type 'B'\n", + type); + return NULL; + + } + + blen += 5; // sub-type & length + tmp += itf8_put(tmp, blen); + + // The tag data itself + memcpy(tmp, aux, blen); tmp += blen; aux += blen; + + BLOCK_SIZE(s->aux_FZ_blk) = (uc *)tmp - BLOCK_DATA(s->aux_FZ_blk); + continue; + } + + // Other quality data - {Q2,E2,U2,CQ}:Z and similar + if (((aux[0] == 'Q' && aux[1] == '2') || + (aux[0] == 'U' && aux[1] == '2') || + (aux[0] == 'Q' && aux[1] == 'T') || + (aux[0] == 'C' && aux[1] == 'Q')) && aux[2] == 'Z') { + char *tmp; + if (!s->aux_oq_blk) + if (!(s->aux_oq_blk = cram_new_block(EXTERNAL, DS_aux_oq))) + return NULL; + BLOCK_GROW(s->aux_oq_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_oq_blk); + aux += 3; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; + BLOCK_SIZE(s->aux_oq_blk) = (uc *)tmp - BLOCK_DATA(s->aux_oq_blk); + continue; + } + + // Other sequence data - {R2,E2,CS,BC,RT}:Z and similar + if (((aux[0] == 'R' && aux[1] == '2') || + (aux[0] == 'E' && aux[1] == '2') || + (aux[0] == 'C' && aux[1] == 'S') || + (aux[0] == 'B' && aux[1] == 'C') || + (aux[0] == 'R' && aux[1] == 'T')) && aux[2] == 'Z') { + char *tmp; + if (!s->aux_os_blk) + if (!(s->aux_os_blk = cram_new_block(EXTERNAL, DS_aux_os))) + return NULL; + BLOCK_GROW(s->aux_os_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_os_blk); + aux += 3; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; + BLOCK_SIZE(s->aux_os_blk) = (uc *)tmp - BLOCK_DATA(s->aux_os_blk); + continue; + } + + + switch(aux[2]) { + case 'A': case 'C': case 'c': + aux+=3; + *tmp++=*aux++; + break; + + case 'S': case 's': + aux+=3; + *tmp++=*aux++; *tmp++=*aux++; + break; + + case 'I': case 'i': case 'f': + aux+=3; + *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + break; + + case 'd': + aux+=3; //*tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; *tmp++=*aux++; + break; + + case 'Z': case 'H': + { + char *tmp; + if (!s->aux_oz_blk) + if (!(s->aux_oz_blk = cram_new_block(EXTERNAL, DS_aux_oz))) + return NULL; + BLOCK_GROW(s->aux_oz_blk, aux_size*1.34+1); + tmp = (char *)BLOCK_END(s->aux_oz_blk); + aux += 3; + while ((*tmp++=*aux++)); + *tmp++ = '\t'; + BLOCK_SIZE(s->aux_oz_blk) = (uc *)tmp - + BLOCK_DATA(s->aux_oz_blk); + } + break; + + case 'B': { + int type = aux[3], blen; + uint32_t count = (uint32_t)((((unsigned char *)aux)[4]<< 0) + + (((unsigned char *)aux)[5]<< 8) + + (((unsigned char *)aux)[6]<<16) + + (((unsigned char *)aux)[7]<<24)); + // skip TN field + aux+=3; + + // We use BYTE_ARRAY_LEN with external length, so store that first + switch (type) { + case 'c': case 'C': + blen = count; + break; + case 's': case 'S': + blen = 2*count; + break; + case 'i': case 'I': case 'f': + blen = 4*count; + break; + default: + fprintf(stderr, "Unknown sub-type '%c' for aux type 'B'\n", + type); + return NULL; + + } + + blen += 5; // sub-type & length + tmp += itf8_put(tmp, blen); + + // The tag data itself + memcpy(tmp, aux, blen); tmp += blen; aux += blen; + + //cram_stats_add(c->aux_B_stats, blen); + break; + } + default: + fprintf(stderr, "Unknown aux type '%c'\n", aux[2]); + return NULL; + } + } + + // FIXME: sort BLOCK_DATA(td_b) by char[3] triples + + // And and increment TD hash entry + BLOCK_APPEND_CHAR(td_b, 0); + + // Duplicate key as BLOCK_DATA() can be realloced to a new pointer. + key = string_ndup(c->comp_hdr->TD_keys, + (char *)BLOCK_DATA(td_b) + TD_blk_size, + BLOCK_SIZE(td_b) - TD_blk_size); + k = kh_put(m_s2i, c->comp_hdr->TD_hash, key, &new); + if (new < 0) { + return NULL; + } else if (new == 0) { + BLOCK_SIZE(td_b) = TD_blk_size; + } else { + kh_val(c->comp_hdr->TD_hash, k) = c->comp_hdr->nTL; + c->comp_hdr->nTL++; + } + + cr->TL = kh_val(c->comp_hdr->TD_hash, k); + cram_stats_add(c->stats[DS_TL], cr->TL); + + cr->aux = BLOCK_SIZE(s->aux_blk); + cr->aux_size = (uc *)tmp - (BLOCK_DATA(s->aux_blk) + cr->aux); + BLOCK_SIZE(s->aux_blk) = (uc *)tmp - BLOCK_DATA(s->aux_blk); + assert(s->aux_blk->byte <= s->aux_blk->alloc); + + return rg; +} + + +/* + * Handles creation of a new container or new slice, flushing any + * existing containers when appropriate. + * + * Really this is next slice, which may or may not lead to a new container. + * + * Returns cram_container pointer on success + * NULL on failure. + */ +static cram_container *cram_next_container(cram_fd *fd, bam_seq_t *b) { + cram_container *c = fd->ctr; + cram_slice *s; + int i; + + /* First occurence */ + if (c->curr_ref == -2) + c->curr_ref = bam_ref(b); + + if (c->slice) { + s = c->slice; + if (c->multi_seq) { + s->hdr->ref_seq_id = -2; + s->hdr->ref_seq_start = 0; + s->hdr->ref_seq_span = 0; + } else { + s->hdr->ref_seq_id = c->curr_ref; + s->hdr->ref_seq_start = c->first_base; + s->hdr->ref_seq_span = c->last_base - c->first_base + 1; + } + s->hdr->num_records = c->curr_rec; + + if (c->curr_slice == 0) { + if (c->ref_seq_id != s->hdr->ref_seq_id) + c->ref_seq_id = s->hdr->ref_seq_id; + c->ref_seq_start = c->first_base; + } + + c->curr_slice++; + } + + /* Flush container */ + if (c->curr_slice == c->max_slice || + (bam_ref(b) != c->curr_ref && !c->multi_seq)) { + c->ref_seq_span = fd->last_base - c->ref_seq_start + 1; + if (fd->verbose) + fprintf(stderr, "Flush container %d/%d..%d\n", + c->ref_seq_id, c->ref_seq_start, + c->ref_seq_start + c->ref_seq_span -1); + + /* Encode slices */ + if (fd->pool) { + if (-1 == cram_flush_container_mt(fd, c)) + return NULL; + } else { + if (-1 == cram_flush_container(fd, c)) + return NULL; + + // Move to sep func, as we need cram_flush_container for + // the closing phase to flush the partial container. + for (i = 0; i < c->max_slice; i++) { + cram_free_slice(c->slices[i]); + c->slices[i] = NULL; + } + + c->slice = NULL; + c->curr_slice = 0; + + /* Easy approach for purposes of freeing stats */ + cram_free_container(c); + } + + c = fd->ctr = cram_new_container(fd->seqs_per_slice, + fd->slices_per_container); + if (!c) + return NULL; + c->record_counter = fd->record_counter; + c->curr_ref = bam_ref(b); + } + + c->last_pos = c->first_base = c->last_base = bam_pos(b)+1; + + /* New slice */ + c->slice = c->slices[c->curr_slice] = + cram_new_slice(MAPPED_SLICE, c->max_rec); + if (!c->slice) + return NULL; + + if (c->multi_seq) { + c->slice->hdr->ref_seq_id = -2; + c->slice->hdr->ref_seq_start = 0; + c->slice->last_apos = 1; + } else { + c->slice->hdr->ref_seq_id = bam_ref(b); + // wrong for unsorted data, will fix during encoding. + c->slice->hdr->ref_seq_start = bam_pos(b)+1; + c->slice->last_apos = bam_pos(b)+1; + } + + c->curr_rec = 0; + + return c; +} + +/* + * Converts a single bam record into a cram record. + * Possibly used within a thread. + * + * Returns 0 on success; + * -1 on failure + */ +static int process_one_read(cram_fd *fd, cram_container *c, + cram_slice *s, cram_record *cr, + bam_seq_t *b, int rnum) { + int i, fake_qual = -1; + char *cp, *rg; + char *ref, *seq, *qual; + + // FIXME: multi-ref containers + + ref = c->ref; + cr->len = bam_seq_len(b); cram_stats_add(c->stats[DS_RL], cr->len); + + //fprintf(stderr, "%s => %d\n", rg ? rg : "\"\"", cr->rg); + + // Fields to resolve later + //cr->mate_line; // index to another cram_record + //cr->mate_flags; // MF + //cr->ntags; // TC + cr->ntags = 0; //cram_stats_add(c->stats[DS_TC], cr->ntags); + if (CRAM_MAJOR_VERS(fd->version) == 1) + rg = cram_encode_aux_1_0(fd, b, c, s, cr); + else + rg = cram_encode_aux(fd, b, c, s, cr); + + //cr->aux_size = b->blk_size - ((char *)bam_aux(b) - (char *)&bam_ref(b)); + //cr->aux = DSTRING_LEN(s->aux_ds); + //dstring_nappend(s->aux_ds, bam_aux(b), cr->aux_size); + + /* Read group, identified earlier */ + if (rg) { + SAM_RG *brg = sam_hdr_find_rg(fd->header, rg); + cr->rg = brg ? brg->id : -1; + } else if (CRAM_MAJOR_VERS(fd->version) == 1) { + SAM_RG *brg = sam_hdr_find_rg(fd->header, "UNKNOWN"); + assert(brg); + } else { + cr->rg = -1; + } + cram_stats_add(c->stats[DS_RG], cr->rg); + + + cr->ref_id = bam_ref(b); cram_stats_add(c->stats[DS_RI], cr->ref_id); + cr->flags = bam_flag(b); + if (bam_cigar_len(b) == 0) + cr->flags |= BAM_FUNMAP; + cram_stats_add(c->stats[DS_BF], fd->cram_flag_swap[cr->flags & 0xfff]); + + // Non reference based encoding means storing the bases verbatim as features, which in + // turn means every base also has a quality already stored. + if (!fd->no_ref || CRAM_MAJOR_VERS(fd->version) >= 3) + cr->cram_flags = CRAM_FLAG_PRESERVE_QUAL_SCORES; + else + cr->cram_flags = 0; + //cram_stats_add(c->stats[DS_CF], cr->cram_flags); + + c->num_bases += cr->len; + cr->apos = bam_pos(b)+1; + if (c->pos_sorted) { + if (cr->apos < s->last_apos) { + c->pos_sorted = 0; + } else { + cram_stats_add(c->stats[DS_AP], cr->apos - s->last_apos); + s->last_apos = cr->apos; + } + } else { + //cram_stats_add(c->stats[DS_AP], cr->apos); + } + c->max_apos += (cr->apos > c->max_apos) * (cr->apos - c->max_apos); + + cr->name = BLOCK_SIZE(s->name_blk); + cr->name_len = bam_name_len(b); + cram_stats_add(c->stats[DS_RN], cr->name_len); + + BLOCK_APPEND(s->name_blk, bam_name(b), bam_name_len(b)); + + + /* + * This seqs_ds is largely pointless and it could reuse the same memory + * over and over. + * s->base_blk is what we need for encoding. + */ + cr->seq = BLOCK_SIZE(s->seqs_blk); + cr->qual = BLOCK_SIZE(s->qual_blk); + BLOCK_GROW(s->seqs_blk, cr->len+1); + BLOCK_GROW(s->qual_blk, cr->len); + seq = cp = (char *)BLOCK_END(s->seqs_blk); + + *seq = 0; +#ifdef ALLOW_UAC + { + // Convert seq 2 bases at a time for speed. + static const uint16_t code2base[256] = { + 15677, 16701, 17213, 19773, 18237, 21053, 21309, 22077, + 21565, 22333, 22845, 18493, 19261, 17469, 16957, 20029, + 15681, 16705, 17217, 19777, 18241, 21057, 21313, 22081, + 21569, 22337, 22849, 18497, 19265, 17473, 16961, 20033, + 15683, 16707, 17219, 19779, 18243, 21059, 21315, 22083, + 21571, 22339, 22851, 18499, 19267, 17475, 16963, 20035, + 15693, 16717, 17229, 19789, 18253, 21069, 21325, 22093, + 21581, 22349, 22861, 18509, 19277, 17485, 16973, 20045, + 15687, 16711, 17223, 19783, 18247, 21063, 21319, 22087, + 21575, 22343, 22855, 18503, 19271, 17479, 16967, 20039, + 15698, 16722, 17234, 19794, 18258, 21074, 21330, 22098, + 21586, 22354, 22866, 18514, 19282, 17490, 16978, 20050, + 15699, 16723, 17235, 19795, 18259, 21075, 21331, 22099, + 21587, 22355, 22867, 18515, 19283, 17491, 16979, 20051, + 15702, 16726, 17238, 19798, 18262, 21078, 21334, 22102, + 21590, 22358, 22870, 18518, 19286, 17494, 16982, 20054, + 15700, 16724, 17236, 19796, 18260, 21076, 21332, 22100, + 21588, 22356, 22868, 18516, 19284, 17492, 16980, 20052, + 15703, 16727, 17239, 19799, 18263, 21079, 21335, 22103, + 21591, 22359, 22871, 18519, 19287, 17495, 16983, 20055, + 15705, 16729, 17241, 19801, 18265, 21081, 21337, 22105, + 21593, 22361, 22873, 18521, 19289, 17497, 16985, 20057, + 15688, 16712, 17224, 19784, 18248, 21064, 21320, 22088, + 21576, 22344, 22856, 18504, 19272, 17480, 16968, 20040, + 15691, 16715, 17227, 19787, 18251, 21067, 21323, 22091, + 21579, 22347, 22859, 18507, 19275, 17483, 16971, 20043, + 15684, 16708, 17220, 19780, 18244, 21060, 21316, 22084, + 21572, 22340, 22852, 18500, 19268, 17476, 16964, 20036, + 15682, 16706, 17218, 19778, 18242, 21058, 21314, 22082, + 21570, 22338, 22850, 18498, 19266, 17474, 16962, 20034, + 15694, 16718, 17230, 19790, 18254, 21070, 21326, 22094, + 21582, 22350, 22862, 18510, 19278, 17486, 16974, 20046 + }; + + int l2 = cr->len / 2; + unsigned char *from = (unsigned char *)bam_seq(b); + uint16_t *cpi = (uint16_t *)cp; + cp[0] = 0; + for (i = 0; i < l2; i++) + cpi[i] = le_int2(code2base[from[i]]); + if ((i *= 2) < cr->len) + cp[i] = seq_nt16_str[bam_seqi(bam_seq(b), i)]; + } +#else + for (i = 0; i < cr->len; i++) + cp[i] = seq_nt16_str[bam_seqi(bam_seq(b), i)]; +#endif + BLOCK_SIZE(s->seqs_blk) += cr->len; + + qual = cp = (char *)bam_qual(b); + + /* Copy and parse */ + if (!(cr->flags & BAM_FUNMAP)) { + int32_t *cig_to, *cig_from; + int apos = cr->apos-1, spos = 0; + + cr->cigar = s->ncigar; + cr->ncigar = bam_cigar_len(b); + while (cr->cigar + cr->ncigar >= s->cigar_alloc) { + s->cigar_alloc = s->cigar_alloc ? s->cigar_alloc*2 : 1024; + s->cigar = realloc(s->cigar, s->cigar_alloc * sizeof(*s->cigar)); + if (!s->cigar) + return -1; + } + + cig_to = (int32_t *)s->cigar; + cig_from = (int32_t *)bam_cigar(b); + + cr->feature = 0; + cr->nfeature = 0; + for (i = 0; i < cr->ncigar; i++) { + enum cigar_op cig_op = cig_from[i] & BAM_CIGAR_MASK; + int cig_len = cig_from[i] >> BAM_CIGAR_SHIFT; + cig_to[i] = cig_from[i]; + + /* Can also generate events from here for CRAM diffs */ + + switch (cig_op) { + int l; + + // Don't trust = and X ops to be correct. + case BAM_CMATCH: + case BAM_CBASE_MATCH: + case BAM_CBASE_MISMATCH: + //fprintf(stderr, "\nBAM_CMATCH\nR: %.*s\nS: %.*s\n", + // cig_len, &ref[apos], cig_len, &seq[spos]); + l = 0; + if (!fd->no_ref && cr->len) { + int end = cig_len+apos < c->ref_end + ? cig_len : c->ref_end - apos; + char *sp = &seq[spos]; + char *rp = &ref[apos]; + char *qp = &qual[spos]; + for (l = 0; l < end; l++) { + if (rp[l] != sp[l]) { + if (!sp[l]) + break; + if (0 && CRAM_MAJOR_VERS(fd->version) >= 3) { + // Disabled for the time being as it doesn't + // seem to gain us much. + int ol=l; + while (l<end && rp[l] != sp[l]) + l++; + if (l-ol > 1) { + if (cram_add_bases(fd, c, s, cr, spos+ol, + l-ol, &seq[spos+ol])) + return -1; + l--; + } else { + l = ol; + if (cram_add_substitution(fd, c, s, cr, + spos+l, sp[l], + qp[l], rp[l])) + return -1; + } + } else { + if (cram_add_substitution(fd, c, s, cr, spos+l, + sp[l], qp[l], rp[l])) + return -1; + } + } + } + spos += l; + apos += l; + } + + if (l < cig_len && cr->len) { + if (fd->no_ref) { + if (CRAM_MAJOR_VERS(fd->version) == 3) { + if (cram_add_bases(fd, c, s, cr, spos, + cig_len-l, &seq[spos])) + return -1; + spos += cig_len-l; + } else { + for (; l < cig_len && seq[spos]; l++, spos++) { + if (cram_add_base(fd, c, s, cr, spos, + seq[spos], qual[spos])) + return -1; + } + } + } else { + /* off end of sequence or non-ref based output */ + for (; l < cig_len && seq[spos]; l++, spos++) { + if (cram_add_base(fd, c, s, cr, spos, + seq[spos], qual[spos])) + return -1; + } + } + apos += cig_len; + } else if (!cr->len) { + /* Seq "*" */ + apos += cig_len; + spos += cig_len; + } + break; + + case BAM_CDEL: + if (cram_add_deletion(c, s, cr, spos, cig_len, &seq[spos])) + return -1; + apos += cig_len; + break; + + case BAM_CREF_SKIP: + if (cram_add_skip(c, s, cr, spos, cig_len, &seq[spos])) + return -1; + apos += cig_len; + break; + + case BAM_CINS: + if (cram_add_insertion(c, s, cr, spos, cig_len, + cr->len ? &seq[spos] : NULL)) + return -1; + if (fd->no_ref && cr->len) { + for (l = 0; l < cig_len; l++, spos++) { + cram_add_quality(fd, c, s, cr, spos, qual[spos]); + } + } else { + spos += cig_len; + } + break; + + case BAM_CSOFT_CLIP: + if (cram_add_softclip(c, s, cr, spos, cig_len, + cr->len ? &seq[spos] : NULL, + fd->version)) + return -1; + if (fd->no_ref && + !(cr->cram_flags & CRAM_FLAG_PRESERVE_QUAL_SCORES)) { + if (cr->len) { + for (l = 0; l < cig_len; l++, spos++) { + cram_add_quality(fd, c, s, cr, spos, qual[spos]); + } + } else { + for (l = 0; l < cig_len; l++, spos++) { + cram_add_quality(fd, c, s, cr, spos, -1); + } + } + } else { + spos += cig_len; + } + break; + + case BAM_CHARD_CLIP: + if (cram_add_hardclip(c, s, cr, spos, cig_len, &seq[spos])) + return -1; + break; + + case BAM_CPAD: + if (cram_add_pad(c, s, cr, spos, cig_len, &seq[spos])) + return -1; + break; + } + } + fake_qual = spos; + cr->aend = MIN(apos, c->ref_end); + cram_stats_add(c->stats[DS_FN], cr->nfeature); + } else { + // Unmapped + cr->cram_flags |= CRAM_FLAG_PRESERVE_QUAL_SCORES; + cr->cigar = 0; + cr->ncigar = 0; + cr->nfeature = 0; + cr->aend = cr->apos; + for (i = 0; i < cr->len; i++) + cram_stats_add(c->stats[DS_BA], seq[i]); + } + + /* + * Append to the qual block now. We do this here as + * cram_add_substitution() can generate BA/QS events which need to + * be in the qual block before we append the rest of the data. + */ + if (cr->cram_flags & CRAM_FLAG_PRESERVE_QUAL_SCORES) { + /* Special case of seq "*" */ + if (cr->len == 0) { + cram_stats_add(c->stats[DS_RL], cr->len = fake_qual); + BLOCK_GROW(s->qual_blk, cr->len); + cp = (char *)BLOCK_END(s->qual_blk); + memset(cp, 255, cr->len); + } else { + BLOCK_GROW(s->qual_blk, cr->len); + cp = (char *)BLOCK_END(s->qual_blk); + char *from = (char *)&bam_qual(b)[0]; + char *to = &cp[0]; + memcpy(to, from, cr->len); + //for (i = 0; i < cr->len; i++) cp[i] = from[i]; + } + BLOCK_SIZE(s->qual_blk) += cr->len; + } else { + if (cr->len == 0) { + cr->len = fake_qual >= 0 ? fake_qual : cr->aend - cr->apos + 1; + cram_stats_add(c->stats[DS_RL], cr->len); + } + } + + /* Now we know apos and aend both, update mate-pair information */ + { + int new; + khint_t k; + int sec = (cr->flags & BAM_FSECONDARY) ? 1 : 0; + + //fprintf(stderr, "Checking %"PRId64"/%.*s\t", rnum, + // cr->name_len, DSTRING_STR(s->name_ds)+cr->name); + if (cr->flags & BAM_FPAIRED) { + char *key = string_ndup(s->pair_keys, + (char *)BLOCK_DATA(s->name_blk)+cr->name, + cr->name_len); + if (!key) + return -1; + + k = kh_put(m_s2i, s->pair[sec], key, &new); + if (-1 == new) + return -1; + else if (new > 0) + kh_val(s->pair[sec], k) = rnum; + } else { + new = 1; + } + + if (new == 0) { + cram_record *p = &s->crecs[kh_val(s->pair[sec], k)]; + int aleft, aright, sign; + + aleft = MIN(cr->apos, p->apos); + aright = MAX(cr->aend, p->aend); + if (cr->apos < p->apos) { + sign = 1; + } else if (cr->apos > p->apos) { + sign = -1; + } else if (cr->flags & BAM_FREAD1) { + sign = 1; + } else { + sign = -1; + } + + //fprintf(stderr, "paired %"PRId64"\n", kh_val(s->pair[sec], k)); + + // This vs p: tlen, matepos, flags + if (bam_ins_size(b) != sign*(aright-aleft+1)) + goto detached; + + if (MAX(bam_mate_pos(b)+1, 0) != p->apos) + goto detached; + + if (((bam_flag(b) & BAM_FMUNMAP) != 0) != + ((p->flags & BAM_FUNMAP) != 0)) + goto detached; + + if (((bam_flag(b) & BAM_FMREVERSE) != 0) != + ((p->flags & BAM_FREVERSE) != 0)) + goto detached; + + + // p vs this: tlen, matepos, flags + if (p->tlen != -sign*(aright-aleft+1)) + goto detached; + + if (p->mate_pos != cr->apos) + goto detached; + + if (((p->flags & BAM_FMUNMAP) != 0) != + ((p->mate_flags & CRAM_M_UNMAP) != 0)) + goto detached; + + if (((p->flags & BAM_FMREVERSE) != 0) != + ((p->mate_flags & CRAM_M_REVERSE) != 0)) + goto detached; + + // Supplementary reads are just too ill defined + if ((cr->flags & BAM_FSUPPLEMENTARY) || + (p->flags & BAM_FSUPPLEMENTARY)) + goto detached; + + /* + * The fields below are unused when encoding this read as it is + * no longer detached. In theory they may get referred to when + * processing a 3rd or 4th read in this template?, so we set them + * here just to be sure. + * + * They do not need cram_stats_add() calls those as they are + * not emitted. + */ + cr->mate_pos = p->apos; + cr->tlen = sign*(aright-aleft+1); + cr->mate_flags = + ((p->flags & BAM_FMUNMAP) == BAM_FMUNMAP) * CRAM_M_UNMAP + + ((p->flags & BAM_FMREVERSE) == BAM_FMREVERSE) * CRAM_M_REVERSE; + + // Decrement statistics aggregated earlier + cram_stats_del(c->stats[DS_NP], p->mate_pos); + cram_stats_del(c->stats[DS_MF], p->mate_flags); + cram_stats_del(c->stats[DS_TS], p->tlen); + cram_stats_del(c->stats[DS_NS], p->mate_ref_id); + + /* Similarly we could correct the p-> values too, but these will no + * longer have any code that refers back to them as the new 'p' + * for this template is our current 'cr'. + */ + //p->mate_pos = cr->apos; + //p->mate_flags = + // ((cr->flags & BAM_FMUNMAP) == BAM_FMUNMAP) * CRAM_M_UNMAP + + // ((cr->flags & BAM_FMREVERSE) == BAM_FMREVERSE)* CRAM_M_REVERSE; + //p->tlen = p->apos - cr->aend; + + // Clear detached from cr flags + cr->cram_flags &= ~CRAM_FLAG_DETACHED; + cram_stats_add(c->stats[DS_CF], cr->cram_flags); + + // Clear detached from p flags and set downstream + cram_stats_del(c->stats[DS_CF], p->cram_flags); + p->cram_flags &= ~CRAM_FLAG_DETACHED; + p->cram_flags |= CRAM_FLAG_MATE_DOWNSTREAM; + cram_stats_add(c->stats[DS_CF], p->cram_flags); + + p->mate_line = rnum - (kh_val(s->pair[sec], k) + 1); + cram_stats_add(c->stats[DS_NF], p->mate_line); + + kh_val(s->pair[sec], k) = rnum; + } else { + detached: + //fprintf(stderr, "unpaired\n"); + + /* Derive mate flags from this flag */ + cr->mate_flags = 0; + if (bam_flag(b) & BAM_FMUNMAP) + cr->mate_flags |= CRAM_M_UNMAP; + if (bam_flag(b) & BAM_FMREVERSE) + cr->mate_flags |= CRAM_M_REVERSE; + + cram_stats_add(c->stats[DS_MF], cr->mate_flags); + + cr->mate_pos = MAX(bam_mate_pos(b)+1, 0); + cram_stats_add(c->stats[DS_NP], cr->mate_pos); + + cr->tlen = bam_ins_size(b); + cram_stats_add(c->stats[DS_TS], cr->tlen); + + cr->cram_flags |= CRAM_FLAG_DETACHED; + cram_stats_add(c->stats[DS_CF], cr->cram_flags); + cram_stats_add(c->stats[DS_NS], bam_mate_ref(b)); + } + } + + cr->mqual = bam_map_qual(b); + cram_stats_add(c->stats[DS_MQ], cr->mqual); + + cr->mate_ref_id = bam_mate_ref(b); + + if (!(bam_flag(b) & BAM_FUNMAP)) { + if (c->first_base > cr->apos) + c->first_base = cr->apos; + + if (c->last_base < cr->aend) + c->last_base = cr->aend; + } + + return 0; +} + +/* + * Write iterator: put BAM format sequences into a CRAM file. + * We buffer up a containers worth of data at a time. + * + * Returns 0 on success + * -1 on failure + */ +int cram_put_bam_seq(cram_fd *fd, bam_seq_t *b) { + cram_container *c; + + if (!fd->ctr) { + fd->ctr = cram_new_container(fd->seqs_per_slice, + fd->slices_per_container); + if (!fd->ctr) + return -1; + fd->ctr->record_counter = fd->record_counter; + } + c = fd->ctr; + + if (!c->slice || c->curr_rec == c->max_rec || + (bam_ref(b) != c->curr_ref && c->curr_ref >= -1)) { + int slice_rec, curr_rec, multi_seq = fd->multi_seq == 1; + int curr_ref = c->slice ? c->curr_ref : bam_ref(b); + + + /* + * Start packing slices when we routinely have under 1/4tr full. + * + * This option isn't available if we choose to embed references + * since we can only have one per slice. + */ + if (fd->multi_seq == -1 && c->curr_rec < c->max_rec/4+10 && + fd->last_slice && fd->last_slice < c->max_rec/4+10 && + !fd->embed_ref) { + if (fd->verbose && !c->multi_seq) + fprintf(stderr, "Multi-ref enabled for this container\n"); + multi_seq = 1; + } + + slice_rec = c->slice_rec; + curr_rec = c->curr_rec; + + if (CRAM_MAJOR_VERS(fd->version) == 1 || + c->curr_rec == c->max_rec || fd->multi_seq != 1 || !c->slice) { + if (NULL == (c = cram_next_container(fd, b))) { + if (fd->ctr) { + // prevent cram_close attempting to flush + cram_free_container(fd->ctr); + fd->ctr = NULL; + } + return -1; + } + } + + /* + * Due to our processing order, some things we've already done we + * cannot easily undo. So when we first notice we should be packing + * multiple sequences per container we emit the small partial + * container as-is and then start a fresh one in a different mode. + */ + if (multi_seq) { + fd->multi_seq = 1; + c->multi_seq = 1; + c->pos_sorted = 0; // required atm for multi_seq slices + + if (!c->refs_used) { + pthread_mutex_lock(&fd->ref_lock); + c->refs_used = calloc(fd->refs->nref, sizeof(int)); + pthread_mutex_unlock(&fd->ref_lock); + if (!c->refs_used) + return -1; + } + } + + fd->last_slice = curr_rec - slice_rec; + c->slice_rec = c->curr_rec; + + // Have we seen this reference before? + if (bam_ref(b) >= 0 && bam_ref(b) != curr_ref && !fd->embed_ref && + !fd->unsorted && multi_seq) { + + if (!c->refs_used) { + pthread_mutex_lock(&fd->ref_lock); + c->refs_used = calloc(fd->refs->nref, sizeof(int)); + pthread_mutex_unlock(&fd->ref_lock); + if (!c->refs_used) + return -1; + } else if (c->refs_used && c->refs_used[bam_ref(b)]) { + fprintf(stderr, "Unsorted mode enabled\n"); + pthread_mutex_lock(&fd->ref_lock); + fd->unsorted = 1; + pthread_mutex_unlock(&fd->ref_lock); + fd->multi_seq = 1; + } + } + + c->curr_ref = bam_ref(b); + if (c->refs_used && c->curr_ref >= 0) c->refs_used[c->curr_ref]++; + } + + if (!c->bams) { + /* First time through, allocate a set of bam pointers */ + pthread_mutex_lock(&fd->bam_list_lock); + if (fd->bl) { + spare_bams *spare = fd->bl; + c->bams = spare->bams; + fd->bl = spare->next; + free(spare); + } else { + c->bams = calloc(c->max_c_rec, sizeof(bam_seq_t *)); + if (!c->bams) + return -1; + } + pthread_mutex_unlock(&fd->bam_list_lock); + } + + /* Copy or alloc+copy the bam record, for later encoding */ + if (c->bams[c->curr_c_rec]) + bam_copy1(c->bams[c->curr_c_rec], b); + else + c->bams[c->curr_c_rec] = bam_dup(b); + + c->curr_rec++; + c->curr_c_rec++; + fd->record_counter++; + + return 0; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_encode.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,105 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/*! \file + * Include cram.h instead. + * + * This is an internal part of the CRAM system and is automatically included + * when you #include cram.h. + * + * Implements the encoding portion of CRAM I/O. Also see + * cram_codecs.[ch] for the actual encoding functions themselves. + */ + +#ifndef _CRAM_WRITE_H_ +#define _CRAM_WRITE_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +/* ---------------------------------------------------------------------- + * CRAM sequence iterators. + */ + +/*! Write iterator: put BAM format sequences into a CRAM file. + * + * We buffer up a containers worth of data at a time. + * + * FIXME: break this into smaller pieces. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_put_bam_seq(cram_fd *fd, bam_seq_t *b); + + +/* ---------------------------------------------------------------------- + * Internal functions + */ + +/*! INTERNAL: + * Encodes a compression header block into a generic cram_block structure. + * + * @return + * Returns cram_block ptr on success; + * NULL on failure + */ +cram_block *cram_encode_compression_header(cram_fd *fd, cram_container *c, + cram_block_compression_hdr *h); + +/*! INTERNAL: + * Encodes a slice compression header. + * + * @return + * Returns cram_block on success; + * NULL on failure + */ +cram_block *cram_encode_slice_header(cram_fd *fd, cram_slice *s); + +/*! INTERNAL: + * Encodes all slices in a container into blocks. + * + * @return + * Returns 0 on success; + * -1 on failure + * + * FIXME: separate into encode_container and write_container. Ideally + * we should be able to do read_container / write_container or + * decode_container / encode_container. + */ +int cram_encode_container(cram_fd *fd, cram_container *c); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_index.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,557 @@ +/* +Copyright (c) 2013-2014 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* + * The index is a gzipped tab-delimited text file with one line per slice. + * The columns are: + * 1: reference number (0 to N-1, as per BAM ref_id) + * 2: reference position of 1st read in slice (1..?) + * 3: number of reads in slice + * 4: offset of container start (relative to end of SAM header, so 1st + * container is offset 0). + * 5: slice number within container (ie which landmark). + * + * In memory, we hold this in a nested containment list. Each list element is + * a cram_index struct. Each element in turn can contain its own list of + * cram_index structs. + * + * Any start..end range which is entirely contained within another (and + * earlier as it is sorted) range will be held within it. This ensures that + * the outer list will never have containments and we can safely do a + * binary search to find the first range which overlaps any given coordinate. + */ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdio.h> +#include <errno.h> +#include <assert.h> +#include <stdlib.h> +#include <string.h> +#include <zlib.h> +#include <sys/types.h> +#include <sys/stat.h> +#include <math.h> +#include <ctype.h> + +#include "htslib/hfile.h" +#include "cram/cram.h" +#include "cram/os.h" +#include "cram/zfio.h" + +#if 0 +static void dump_index_(cram_index *e, int level) { + int i, n; + n = printf("%*s%d / %d .. %d, ", level*4, "", e->refid, e->start, e->end); + printf("%*soffset %"PRId64"\n", MAX(0,50-n), "", e->offset); + for (i = 0; i < e->nslice; i++) { + dump_index_(&e->e[i], level+1); + } +} + +static void dump_index(cram_fd *fd) { + int i; + for (i = 0; i < fd->index_sz; i++) { + dump_index_(&fd->index[i], 0); + } +} +#endif + +static int kget_int32(kstring_t *k, size_t *pos, int32_t *val_p) { + int sign = 1; + int32_t val = 0; + size_t p = *pos; + + while (p < k->l && (k->s[p] == ' ' || k->s[p] == '\t')) + p++; + + if (p < k->l && k->s[p] == '-') + sign = -1, p++; + + if (p >= k->l || !(k->s[p] >= '0' && k->s[p] <= '9')) + return -1; + + while (p < k->l && k->s[p] >= '0' && k->s[p] <= '9') + val = val*10 + k->s[p++]-'0'; + + *pos = p; + *val_p = sign*val; + + return 0; +} + +static int kget_int64(kstring_t *k, size_t *pos, int64_t *val_p) { + int sign = 1; + int64_t val = 0; + size_t p = *pos; + + while (p < k->l && (k->s[p] == ' ' || k->s[p] == '\t')) + p++; + + if (p < k->l && k->s[p] == '-') + sign = -1, p++; + + if (p >= k->l || !(k->s[p] >= '0' && k->s[p] <= '9')) + return -1; + + while (p < k->l && k->s[p] >= '0' && k->s[p] <= '9') + val = val*10 + k->s[p++]-'0'; + + *pos = p; + *val_p = sign*val; + + return 0; +} + +/* + * Loads a CRAM .crai index into memory. + * + * Returns 0 for success + * -1 for failure + */ +int cram_index_load(cram_fd *fd, const char *fn) { + char fn2[PATH_MAX]; + char buf[65536]; + ssize_t len; + kstring_t kstr = {0}; + hFILE *fp; + cram_index *idx; + cram_index **idx_stack = NULL, *ep, e; + int idx_stack_alloc = 0, idx_stack_ptr = 0; + size_t pos = 0; + + /* Check if already loaded */ + if (fd->index) + return 0; + + fd->index = calloc((fd->index_sz = 1), sizeof(*fd->index)); + if (!fd->index) + return -1; + + idx = &fd->index[0]; + idx->refid = -1; + idx->start = INT_MIN; + idx->end = INT_MAX; + + idx_stack = calloc(++idx_stack_alloc, sizeof(*idx_stack)); + idx_stack[idx_stack_ptr] = idx; + + sprintf(fn2, "%s.crai", fn); + if (!(fp = hopen(fn2, "r"))) { + perror(fn2); + free(idx_stack); + return -1; + } + + // Load the file into memory + while ((len = hread(fp, buf, 65536)) > 0) + kputsn(buf, len, &kstr); + if (len < 0 || kstr.l < 2) { + if (kstr.s) + free(kstr.s); + free(idx_stack); + return -1; + } + + if (hclose(fp)) { + if (kstr.s) + free(kstr.s); + free(idx_stack); + return -1; + } + + + // Uncompress if required + if (kstr.s[0] == 31 && (uc)kstr.s[1] == 139) { + size_t l; + char *s = zlib_mem_inflate(kstr.s, kstr.l, &l); + free(kstr.s); + if (!s) { + free(idx_stack); + return -1; + } + kstr.s = s; + kstr.l = l; + kstr.m = l; // conservative estimate of the size allocated + kputsn("", 0, &kstr); // ensure kstr.s is NUL-terminated + } + + + // Parse it line at a time + do { + /* 1.1 layout */ + if (kget_int32(&kstr, &pos, &e.refid) == -1) { + free(kstr.s); free(idx_stack); return -1; + } + if (kget_int32(&kstr, &pos, &e.start) == -1) { + free(kstr.s); free(idx_stack); return -1; + } + if (kget_int32(&kstr, &pos, &e.end) == -1) { + free(kstr.s); free(idx_stack); return -1; + } + if (kget_int64(&kstr, &pos, &e.offset) == -1) { + free(kstr.s); free(idx_stack); return -1; + } + if (kget_int32(&kstr, &pos, &e.slice) == -1) { + free(kstr.s); free(idx_stack); return -1; + } + if (kget_int32(&kstr, &pos, &e.len) == -1) { + free(kstr.s); free(idx_stack); return -1; + } + + e.end += e.start-1; + //printf("%d/%d..%d\n", e.refid, e.start, e.end); + + if (e.refid < -1) { + free(kstr.s); + free(idx_stack); + fprintf(stderr, "Malformed index file, refid %d\n", e.refid); + return -1; + } + + if (e.refid != idx->refid) { + if (fd->index_sz < e.refid+2) { + size_t index_end = fd->index_sz * sizeof(*fd->index); + fd->index_sz = e.refid+2; + fd->index = realloc(fd->index, + fd->index_sz * sizeof(*fd->index)); + memset(((char *)fd->index) + index_end, 0, + fd->index_sz * sizeof(*fd->index) - index_end); + } + idx = &fd->index[e.refid+1]; + idx->refid = e.refid; + idx->start = INT_MIN; + idx->end = INT_MAX; + idx->nslice = idx->nalloc = 0; + idx->e = NULL; + idx_stack[(idx_stack_ptr = 0)] = idx; + } + + while (!(e.start >= idx->start && e.end <= idx->end)) { + idx = idx_stack[--idx_stack_ptr]; + } + + // Now contains, so append + if (idx->nslice+1 >= idx->nalloc) { + idx->nalloc = idx->nalloc ? idx->nalloc*2 : 16; + idx->e = realloc(idx->e, idx->nalloc * sizeof(*idx->e)); + } + + e.nalloc = e.nslice = 0; e.e = NULL; + *(ep = &idx->e[idx->nslice++]) = e; + idx = ep; + + if (++idx_stack_ptr >= idx_stack_alloc) { + idx_stack_alloc *= 2; + idx_stack = realloc(idx_stack, idx_stack_alloc*sizeof(*idx_stack)); + } + idx_stack[idx_stack_ptr] = idx; + + while (pos < kstr.l && kstr.s[pos] != '\n') + pos++; + pos++; + } while (pos < kstr.l); + + free(idx_stack); + free(kstr.s); + + // dump_index(fd); + + return 0; +} + +static void cram_index_free_recurse(cram_index *e) { + if (e->e) { + int i; + for (i = 0; i < e->nslice; i++) { + cram_index_free_recurse(&e->e[i]); + } + free(e->e); + } +} + +void cram_index_free(cram_fd *fd) { + int i; + + if (!fd->index) + return; + + for (i = 0; i < fd->index_sz; i++) { + cram_index_free_recurse(&fd->index[i]); + } + free(fd->index); + + fd->index = NULL; +} + +/* + * Searches the index for the first slice overlapping a reference ID + * and position, or one immediately preceding it if none is found in + * the index to overlap this position. (Our index may have missing + * entries, but we require at least one per reference.) + * + * If the index finds multiple slices overlapping this position we + * return the first one only. Subsequent calls should specifying + * "from" as the last slice we checked to find the next one. Otherwise + * set "from" to be NULL to find the first one. + * + * Returns the cram_index pointer on sucess + * NULL on failure + */ +cram_index *cram_index_query(cram_fd *fd, int refid, int pos, + cram_index *from) { + int i, j, k; + cram_index *e; + + if (refid+1 < 0 || refid+1 >= fd->index_sz) + return NULL; + + i = 0, j = fd->index[refid+1].nslice-1; + + if (!from) + from = &fd->index[refid+1]; + + for (k = j/2; k != i; k = (j-i)/2 + i) { + if (from->e[k].refid > refid) { + j = k; + continue; + } + + if (from->e[k].refid < refid) { + i = k; + continue; + } + + if (from->e[k].start >= pos) { + j = k; + continue; + } + + if (from->e[k].start < pos) { + i = k; + continue; + } + } + // i==j or i==j-1. Check if j is better. + if (from->e[j].start < pos && from->e[j].refid == refid) + i = j; + + /* The above found *a* bin overlapping, but not necessarily the first */ + while (i > 0 && from->e[i-1].end >= pos) + i--; + + /* Special case for matching a start pos */ + if (i+1 < from->nslice && + from->e[i+1].start == pos && + from->e[i+1].refid == refid) + i++; + + e = &from->e[i]; + + return e; +} + + +/* + * Skips to a container overlapping the start coordinate listed in + * cram_range. + * + * In theory we call cram_index_query multiple times, once per slice + * overlapping the range. However slices may be absent from the index + * which makes this problematic. Instead we find the left-most slice + * and then read from then on, skipping decoding of slices and/or + * whole containers when they don't overlap the specified cram_range. + * + * Returns 0 on success + * -1 on failure + */ +int cram_seek_to_refpos(cram_fd *fd, cram_range *r) { + cram_index *e; + + // Ideally use an index, so see if we have one. + if ((e = cram_index_query(fd, r->refid, r->start, NULL))) { + if (0 != cram_seek(fd, e->offset, SEEK_SET)) + if (0 != cram_seek(fd, e->offset - fd->first_container, SEEK_CUR)) + return -1; + } else { + fprintf(stderr, "Unknown reference ID. Missing from index?\n"); + return -1; + } + + if (fd->ctr) { + cram_free_container(fd->ctr); + fd->ctr = NULL; + fd->ooc = 0; + } + + return 0; +} + + +/* + * A specialised form of cram_index_build (below) that deals with slices + * having multiple references in this (ref_id -2). In this scenario we + * decode the slice to look at the RI data series instead. + * + * Returns 0 on success + * -1 on failure + */ +static int cram_index_build_multiref(cram_fd *fd, + cram_container *c, + cram_slice *s, + zfp *fp, + off_t cpos, + int32_t landmark, + int sz) { + int i, ref = -2, ref_start = 0, ref_end; + char buf[1024]; + + if (0 != cram_decode_slice(fd, c, s, fd->header)) + return -1; + + ref_end = INT_MIN; + for (i = 0; i < s->hdr->num_records; i++) { + if (s->crecs[i].ref_id == ref) { + if (ref_end < s->crecs[i].aend) + ref_end = s->crecs[i].aend; + continue; + } + + if (ref != -2) { + sprintf(buf, "%d\t%d\t%d\t%"PRId64"\t%d\t%d\n", + ref, ref_start, ref_end - ref_start + 1, + (int64_t)cpos, landmark, sz); + zfputs(buf, fp); + } + + ref = s->crecs[i].ref_id; + ref_start = s->crecs[i].apos; + ref_end = INT_MIN; + } + + if (ref != -2) { + sprintf(buf, "%d\t%d\t%d\t%"PRId64"\t%d\t%d\n", + ref, ref_start, ref_end - ref_start + 1, + (int64_t)cpos, landmark, sz); + zfputs(buf, fp); + } + + return 0; +} + +/* + * Builds an index file. + * + * fd is a newly opened cram file that we wish to index. + * fn_base is the filename of the associated CRAM file. Internally we + * add ".crai" to this to get the index filename. + * + * Returns 0 on success + * -1 on failure + */ +int cram_index_build(cram_fd *fd, const char *fn_base) { + cram_container *c; + off_t cpos, spos, hpos; + zfp *fp; + char fn_idx[PATH_MAX]; + + if (strlen(fn_base) > PATH_MAX-6) + return -1; + + sprintf(fn_idx, "%s.crai", fn_base); + if (!(fp = zfopen(fn_idx, "wz"))) { + perror(fn_idx); + return -1; + } + + cpos = htell(fd->fp); + while ((c = cram_read_container(fd))) { + int j; + + if (fd->err) { + perror("Cram container read"); + return 1; + } + + hpos = htell(fd->fp); + + if (!(c->comp_hdr_block = cram_read_block(fd))) + return 1; + assert(c->comp_hdr_block->content_type == COMPRESSION_HEADER); + + c->comp_hdr = cram_decode_compression_header(fd, c->comp_hdr_block); + if (!c->comp_hdr) + return -1; + + // 2.0 format + for (j = 0; j < c->num_landmarks; j++) { + char buf[1024]; + cram_slice *s; + int sz; + + spos = htell(fd->fp); + assert(spos - cpos - c->offset == c->landmark[j]); + + if (!(s = cram_read_slice(fd))) { + zfclose(fp); + return -1; + } + + sz = (int)(htell(fd->fp) - spos); + + if (s->hdr->ref_seq_id == -2) { + cram_index_build_multiref(fd, c, s, fp, + cpos, c->landmark[j], sz); + } else { + sprintf(buf, "%d\t%d\t%d\t%"PRId64"\t%d\t%d\n", + s->hdr->ref_seq_id, s->hdr->ref_seq_start, + s->hdr->ref_seq_span, (int64_t)cpos, + c->landmark[j], sz); + zfputs(buf, fp); + } + + cram_free_slice(s); + } + + cpos = htell(fd->fp); + assert(cpos == hpos + c->length); + + cram_free_container(c); + } + if (fd->err) { + zfclose(fp); + return -1; + } + + + return zfclose(fp); +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_index.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,98 @@ +/* +Copyright (c) 2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _CRAM_INDEX_H_ +#define _CRAM_INDEX_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +/* + * Loads a CRAM .crai index into memory. + * Returns 0 for success + * -1 for failure + */ +int cram_index_load(cram_fd *fd, const char *fn); + +void cram_index_free(cram_fd *fd); + +/* + * Searches the index for the first slice overlapping a reference ID + * and position. + * + * Returns the cram_index pointer on sucess + * NULL on failure + */ +cram_index *cram_index_query(cram_fd *fd, int refid, int pos, cram_index *frm); + +/* + * Skips to a container overlapping the start coordinate listed in + * cram_range. + * + * Returns 0 on success + * -1 on failure + */ +int cram_seek_to_refpos(cram_fd *fd, cram_range *r); + +void cram_index_free(cram_fd *fd); + +/* + * Skips to a container overlapping the start coordinate listed in + * cram_range. + * + * In theory we call cram_index_query multiple times, once per slice + * overlapping the range. However slices may be absent from the index + * which makes this problematic. Instead we find the left-most slice + * and then read from then on, skipping decoding of slices and/or + * whole containers when they don't overlap the specified cram_range. + * + * Returns 0 on success + * -1 on failure + */ +int cram_seek_to_refpos(cram_fd *fd, cram_range *r); + +/* + * Builds an index file. + * + * fd is a newly opened cram file that we wish to index. + * fn_base is the filename of the associated CRAM file. Internally we + * add ".crai" to this to get the index filename. + * + * Returns 0 on success + * -1 on failure + */ +int cram_index_build(cram_fd *fd, const char *fn_base); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_io.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,4202 @@ +/* +Copyright (c) 2012-2014 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* + * CRAM I/O primitives. + * + * - ITF8 encoding and decoding. + * - Block based I/O + * - Zlib inflating and deflating (memory) + * - CRAM basic data structure reading and writing + * - File opening / closing + * - Reference sequence handling + */ + +/* + * TODO: BLOCK_GROW, BLOCK_RESIZE, BLOCK_APPEND and itf8_put_blk all need + * a way to return errors for when malloc fails. + */ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdio.h> +#include <errno.h> +#include <assert.h> +#include <stdlib.h> +#include <string.h> +#include <zlib.h> +#ifdef HAVE_LIBBZ2 +#include <bzlib.h> +#endif +#ifdef HAVE_LIBLZMA +#include <lzma.h> +#endif +#include <sys/types.h> +#include <sys/stat.h> +#include <math.h> +#include <ctype.h> + +#include "cram/cram.h" +#include "cram/os.h" +#include "cram/md5.h" +#include "cram/open_trace_file.h" +#include "cram/rANS_static.h" + +//#define REF_DEBUG + +#ifdef REF_DEBUG +#include <sys/syscall.h> +#define gettid() (int)syscall(SYS_gettid) + +#define RP(...) fprintf (stderr, __VA_ARGS__) +#else +#define RP(...) +#endif + +#include "htslib/hfile.h" +#include "htslib/bgzf.h" +#include "htslib/faidx.h" + +#define TRIAL_SPAN 50 +#define NTRIALS 3 + + +/* ---------------------------------------------------------------------- + * ITF8 encoding and decoding. + * +* Also see the itf8_get and itf8_put macros in cram_io.h + */ + +/* + * Reads an integer in ITF-8 encoding from 'cp' and stores it in + * *val. + * + * Returns the number of bytes read on success + * -1 on failure + */ +int itf8_decode(cram_fd *fd, int32_t *val_p) { + static int nbytes[16] = { + 0,0,0,0, 0,0,0,0, // 0000xxxx - 0111xxxx + 1,1,1,1, // 1000xxxx - 1011xxxx + 2,2, // 1100xxxx - 1101xxxx + 3, // 1110xxxx + 4, // 1111xxxx + }; + + static int nbits[16] = { + 0x7f, 0x7f, 0x7f, 0x7f, 0x7f, 0x7f, 0x7f, 0x7f, // 0000xxxx - 0111xxxx + 0x3f, 0x3f, 0x3f, 0x3f, // 1000xxxx - 1011xxxx + 0x1f, 0x1f, // 1100xxxx - 1101xxxx + 0x0f, // 1110xxxx + 0x0f, // 1111xxxx + }; + + int32_t val = hgetc(fd->fp); + if (val == -1) + return -1; + + int i = nbytes[val>>4]; + val &= nbits[val>>4]; + + switch(i) { + case 0: + *val_p = val; + return 1; + + case 1: + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val; + return 2; + + case 2: + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val; + return 3; + + case 3: + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val; + return 4; + + case 4: // really 3.5 more, why make it different? + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<4) | (((unsigned char)hgetc(fd->fp)) & 0x0f); + *val_p = val; + } + + return 5; +} + +/* + * Encodes and writes a single integer in ITF-8 format. + * Returns 0 on success + * -1 on failure + */ +int itf8_encode(cram_fd *fd, int32_t val) { + char buf[5]; + int len = itf8_put(buf, val); + return hwrite(fd->fp, buf, len) == len ? 0 : -1; +} + +#ifndef ITF8_MACROS +/* + * As above, but decoding from memory + */ +int itf8_get(char *cp, int32_t *val_p) { + unsigned char *up = (unsigned char *)cp; + + if (up[0] < 0x80) { + *val_p = up[0]; + return 1; + } else if (up[0] < 0xc0) { + *val_p = ((up[0] <<8) | up[1]) & 0x3fff; + return 2; + } else if (up[0] < 0xe0) { + *val_p = ((up[0]<<16) | (up[1]<< 8) | up[2]) & 0x1fffff; + return 3; + } else if (up[0] < 0xf0) { + *val_p = ((up[0]<<24) | (up[1]<<16) | (up[2]<<8) | up[3]) & 0x0fffffff; + return 4; + } else { + *val_p = ((up[0] & 0x0f)<<28) | (up[1]<<20) | (up[2]<<12) | (up[3]<<4) | (up[4] & 0x0f); + return 5; + } +} + +/* + * Stores a value to memory in ITF-8 format. + * + * Returns the number of bytes required to store the number. + * This is a maximum of 5 bytes. + */ +int itf8_put(char *cp, int32_t val) { + if (!(val & ~0x00000007f)) { // 1 byte + *cp = val; + return 1; + } else if (!(val & ~0x00003fff)) { // 2 byte + *cp++ = (val >> 8 ) | 0x80; + *cp = val & 0xff; + return 2; + } else if (!(val & ~0x01fffff)) { // 3 byte + *cp++ = (val >> 16) | 0xc0; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 3; + } else if (!(val & ~0x0fffffff)) { // 4 byte + *cp++ = (val >> 24) | 0xe0; + *cp++ = (val >> 16) & 0xff; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 4; + } else { // 5 byte + *cp++ = 0xf0 | ((val>>28) & 0xff); + *cp++ = (val >> 20) & 0xff; + *cp++ = (val >> 12) & 0xff; + *cp++ = (val >> 4 ) & 0xff; + *cp = val & 0x0f; + return 5; + } +} +#endif + +/* 64-bit itf8 variant */ +int ltf8_put(char *cp, int64_t val) { + if (!(val & ~((1LL<<7)-1))) { + *cp = val; + return 1; + } else if (!(val & ~((1LL<<(6+8))-1))) { + *cp++ = (val >> 8 ) | 0x80; + *cp = val & 0xff; + return 2; + } else if (!(val & ~((1LL<<(5+2*8))-1))) { + *cp++ = (val >> 16) | 0xc0; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 3; + } else if (!(val & ~((1LL<<(4+3*8))-1))) { + *cp++ = (val >> 24) | 0xe0; + *cp++ = (val >> 16) & 0xff; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 4; + } else if (!(val & ~((1LL<<(3+4*8))-1))) { + *cp++ = (val >> 32) | 0xf0; + *cp++ = (val >> 24) & 0xff; + *cp++ = (val >> 16) & 0xff; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 5; + } else if (!(val & ~((1LL<<(2+5*8))-1))) { + *cp++ = (val >> 40) | 0xf8; + *cp++ = (val >> 32) & 0xff; + *cp++ = (val >> 24) & 0xff; + *cp++ = (val >> 16) & 0xff; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 6; + } else if (!(val & ~((1LL<<(1+6*8))-1))) { + *cp++ = (val >> 48) | 0xfc; + *cp++ = (val >> 40) & 0xff; + *cp++ = (val >> 32) & 0xff; + *cp++ = (val >> 24) & 0xff; + *cp++ = (val >> 16) & 0xff; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 7; + } else if (!(val & ~((1LL<<(7*8))-1))) { + *cp++ = (val >> 56) | 0xfe; + *cp++ = (val >> 48) & 0xff; + *cp++ = (val >> 40) & 0xff; + *cp++ = (val >> 32) & 0xff; + *cp++ = (val >> 24) & 0xff; + *cp++ = (val >> 16) & 0xff; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 8; + } else { + *cp++ = 0xff; + *cp++ = (val >> 56) & 0xff; + *cp++ = (val >> 48) & 0xff; + *cp++ = (val >> 40) & 0xff; + *cp++ = (val >> 32) & 0xff; + *cp++ = (val >> 24) & 0xff; + *cp++ = (val >> 16) & 0xff; + *cp++ = (val >> 8 ) & 0xff; + *cp = val & 0xff; + return 9; + } +} + +int ltf8_get(char *cp, int64_t *val_p) { + unsigned char *up = (unsigned char *)cp; + + if (up[0] < 0x80) { + *val_p = up[0]; + return 1; + } else if (up[0] < 0xc0) { + *val_p = (((uint64_t)up[0]<< 8) | + (uint64_t)up[1]) & (((1LL<<(6+8)))-1); + return 2; + } else if (up[0] < 0xe0) { + *val_p = (((uint64_t)up[0]<<16) | + ((uint64_t)up[1]<< 8) | + (uint64_t)up[2]) & ((1LL<<(5+2*8))-1); + return 3; + } else if (up[0] < 0xf0) { + *val_p = (((uint64_t)up[0]<<24) | + ((uint64_t)up[1]<<16) | + ((uint64_t)up[2]<< 8) | + (uint64_t)up[3]) & ((1LL<<(4+3*8))-1); + return 4; + } else if (up[0] < 0xf8) { + *val_p = (((uint64_t)up[0]<<32) | + ((uint64_t)up[1]<<24) | + ((uint64_t)up[2]<<16) | + ((uint64_t)up[3]<< 8) | + (uint64_t)up[4]) & ((1LL<<(3+4*8))-1); + return 5; + } else if (up[0] < 0xfc) { + *val_p = (((uint64_t)up[0]<<40) | + ((uint64_t)up[1]<<32) | + ((uint64_t)up[2]<<24) | + ((uint64_t)up[3]<<16) | + ((uint64_t)up[4]<< 8) | + (uint64_t)up[5]) & ((1LL<<(2+5*8))-1); + return 6; + } else if (up[0] < 0xfe) { + *val_p = (((uint64_t)up[0]<<48) | + ((uint64_t)up[1]<<40) | + ((uint64_t)up[2]<<32) | + ((uint64_t)up[3]<<24) | + ((uint64_t)up[4]<<16) | + ((uint64_t)up[5]<< 8) | + (uint64_t)up[6]) & ((1LL<<(1+6*8))-1); + return 7; + } else if (up[0] < 0xff) { + *val_p = (((uint64_t)up[1]<<48) | + ((uint64_t)up[2]<<40) | + ((uint64_t)up[3]<<32) | + ((uint64_t)up[4]<<24) | + ((uint64_t)up[5]<<16) | + ((uint64_t)up[6]<< 8) | + (uint64_t)up[7]) & ((1LL<<(7*8))-1); + return 8; + } else { + *val_p = (((uint64_t)up[1]<<56) | + ((uint64_t)up[2]<<48) | + ((uint64_t)up[3]<<40) | + ((uint64_t)up[4]<<32) | + ((uint64_t)up[5]<<24) | + ((uint64_t)up[6]<<16) | + ((uint64_t)up[7]<< 8) | + (uint64_t)up[8]); + return 9; + } +} + +int ltf8_decode(cram_fd *fd, int64_t *val_p) { + int c = hgetc(fd->fp); + int64_t val = (unsigned char)c; + if (c == -1) + return -1; + + if (val < 0x80) { + *val_p = val; + return 1; + + } else if (val < 0xc0) { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val & (((1LL<<(6+8)))-1); + return 2; + + } else if (val < 0xe0) { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val & ((1LL<<(5+2*8))-1); + return 3; + + } else if (val < 0xf0) { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val & ((1LL<<(4+3*8))-1); + return 4; + + } else if (val < 0xf8) { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val & ((1LL<<(3+4*8))-1); + return 5; + + } else if (val < 0xfc) { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val & ((1LL<<(2+5*8))-1); + return 6; + + } else if (val < 0xfe) { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val & ((1LL<<(1+6*8))-1); + return 7; + + } else if (val < 0xff) { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val & ((1LL<<(7*8))-1); + return 8; + + } else { + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + val = (val<<8) | (unsigned char)hgetc(fd->fp); + *val_p = val; + } + + return 9; +} + +/* + * Pushes a value in ITF8 format onto the end of a block. + * This shouldn't be used for high-volume data as it is not the fastest + * method. + * + * Returns the number of bytes written + */ +int itf8_put_blk(cram_block *blk, int val) { + char buf[5]; + int sz; + + sz = itf8_put(buf, val); + BLOCK_APPEND(blk, buf, sz); + return sz; +} + +/* + * Decodes a 32-bit little endian value from fd and stores in val. + * + * Returns the number of bytes read on success + * -1 on failure + */ +int int32_decode(cram_fd *fd, int32_t *val) { + int32_t i; + if (4 != hread(fd->fp, &i, 4)) + return -1; + + *val = le_int4(i); + return 4; +} + +/* + * Encodes a 32-bit little endian value 'val' and writes to fd. + * + * Returns the number of bytes written on success + * -1 on failure + */ +int int32_encode(cram_fd *fd, int32_t val) { + val = le_int4(val); + if (4 != hwrite(fd->fp, &val, 4)) + return -1; + + return 4; +} + +/* As int32_decoded/encode, but from/to blocks instead of cram_fd */ +int int32_get(cram_block *b, int32_t *val) { + if (b->uncomp_size - BLOCK_SIZE(b) < 4) + return -1; + + *val = + b->data[b->byte ] | + (b->data[b->byte+1] << 8) | + (b->data[b->byte+2] << 16) | + (b->data[b->byte+3] << 24); + BLOCK_SIZE(b) += 4; + return 4; +} + +/* As int32_decoded/encode, but from/to blocks instead of cram_fd */ +int int32_put(cram_block *b, int32_t val) { + unsigned char cp[4]; + cp[0] = ( val & 0xff); + cp[1] = ((val>>8) & 0xff); + cp[2] = ((val>>16) & 0xff); + cp[3] = ((val>>24) & 0xff); + + BLOCK_APPEND(b, cp, 4); + return b->data ? 0 : -1; +} + +/* ---------------------------------------------------------------------- + * zlib compression code - from Gap5's tg_iface_g.c + * They're static here as they're only used within the cram_compress_block + * and cram_uncompress_block functions, which are the external interface. + */ +char *zlib_mem_inflate(char *cdata, size_t csize, size_t *size) { + z_stream s; + unsigned char *data = NULL; /* Uncompressed output */ + int data_alloc = 0; + int err; + + /* Starting point at uncompressed size, and scale after that */ + data = malloc(data_alloc = csize*1.2+100); + if (!data) + return NULL; + + /* Initialise zlib stream */ + s.zalloc = Z_NULL; /* use default allocation functions */ + s.zfree = Z_NULL; + s.opaque = Z_NULL; + s.next_in = (unsigned char *)cdata; + s.avail_in = csize; + s.total_in = 0; + s.next_out = data; + s.avail_out = data_alloc; + s.total_out = 0; + + //err = inflateInit(&s); + err = inflateInit2(&s, 15 + 32); + if (err != Z_OK) { + fprintf(stderr, "zlib inflateInit error: %s\n", s.msg); + free(data); + return NULL; + } + + /* Decode to 'data' array */ + for (;s.avail_in;) { + unsigned char *data_tmp; + int alloc_inc; + + s.next_out = &data[s.total_out]; + err = inflate(&s, Z_NO_FLUSH); + if (err == Z_STREAM_END) + break; + + if (err != Z_OK) { + fprintf(stderr, "zlib inflate error: %s\n", s.msg); + break; + } + + /* More to come, so realloc based on growth so far */ + alloc_inc = (double)s.avail_in/s.total_in * s.total_out + 100; + data = realloc((data_tmp = data), data_alloc += alloc_inc); + if (!data) { + free(data_tmp); + return NULL; + } + s.avail_out += alloc_inc; + } + inflateEnd(&s); + + *size = s.total_out; + return (char *)data; +} + +static char *zlib_mem_deflate(char *data, size_t size, size_t *cdata_size, + int level, int strat) { + z_stream s; + unsigned char *cdata = NULL; /* Compressed output */ + int cdata_alloc = 0; + int cdata_pos = 0; + int err; + + cdata = malloc(cdata_alloc = size*1.05+100); + if (!cdata) + return NULL; + cdata_pos = 0; + + /* Initialise zlib stream */ + s.zalloc = Z_NULL; /* use default allocation functions */ + s.zfree = Z_NULL; + s.opaque = Z_NULL; + s.next_in = (unsigned char *)data; + s.avail_in = size; + s.total_in = 0; + s.next_out = cdata; + s.avail_out = cdata_alloc; + s.total_out = 0; + s.data_type = Z_BINARY; + + err = deflateInit2(&s, level, Z_DEFLATED, 15|16, 9, strat); + if (err != Z_OK) { + fprintf(stderr, "zlib deflateInit2 error: %s\n", s.msg); + return NULL; + } + + /* Encode to 'cdata' array */ + for (;s.avail_in;) { + s.next_out = &cdata[cdata_pos]; + s.avail_out = cdata_alloc - cdata_pos; + if (cdata_alloc - cdata_pos <= 0) { + fprintf(stderr, "Deflate produced larger output than expected. Abort\n"); + return NULL; + } + err = deflate(&s, Z_NO_FLUSH); + cdata_pos = cdata_alloc - s.avail_out; + if (err != Z_OK) { + fprintf(stderr, "zlib deflate error: %s\n", s.msg); + break; + } + } + if (deflate(&s, Z_FINISH) != Z_STREAM_END) { + fprintf(stderr, "zlib deflate error: %s\n", s.msg); + } + *cdata_size = s.total_out; + + if (deflateEnd(&s) != Z_OK) { + fprintf(stderr, "zlib deflate error: %s\n", s.msg); + } + return (char *)cdata; +} + +#ifdef HAVE_LIBLZMA +/* ------------------------------------------------------------------------ */ +/* + * Data compression routines using liblzma (xz) + * + * On a test set this shrunk the main db from 136157104 bytes to 114796168, but + * caused tg_index to grow from 2m43.707s to 15m3.961s. Exporting as bfastq + * went from 18.3s to 36.3s. So decompression suffers too, but not as bad + * as compression times. + * + * For now we disable this functionality. If it's to be reenabled make sure you + * improve the mem_inflate implementation as it's just a test hack at the + * moment. + */ + +static char *lzma_mem_deflate(char *data, size_t size, size_t *cdata_size, + int level) { + char *out; + size_t out_size = lzma_stream_buffer_bound(size); + *cdata_size = 0; + + out = malloc(out_size); + + /* Single call compression */ + if (LZMA_OK != lzma_easy_buffer_encode(level, LZMA_CHECK_CRC32, NULL, + (uint8_t *)data, size, + (uint8_t *)out, cdata_size, + out_size)) + return NULL; + + return out; +} + +static char *lzma_mem_inflate(char *cdata, size_t csize, size_t *size) { + lzma_stream strm = LZMA_STREAM_INIT; + size_t out_size = 0, out_pos = 0; + char *out = NULL; + int r; + + /* Initiate the decoder */ + if (LZMA_OK != lzma_stream_decoder(&strm, 50000000, 0)) + return NULL; + + /* Decode loop */ + strm.avail_in = csize; + strm.next_in = (uint8_t *)cdata; + + for (;strm.avail_in;) { + if (strm.avail_in > out_size - out_pos) { + out_size += strm.avail_in * 4 + 32768; + out = realloc(out, out_size); + } + strm.avail_out = out_size - out_pos; + strm.next_out = (uint8_t *)&out[out_pos]; + + r = lzma_code(&strm, LZMA_RUN); + if (LZMA_OK != r && LZMA_STREAM_END != r) { + fprintf(stderr, "r=%d\n", r); + fprintf(stderr, "mem=%"PRId64"d\n", (int64_t)lzma_memusage(&strm)); + return NULL; + } + + out_pos = strm.total_out; + + if (r == LZMA_STREAM_END) + break; + } + + /* finish up any unflushed data; necessary? */ + r = lzma_code(&strm, LZMA_FINISH); + if (r != LZMA_OK && r != LZMA_STREAM_END) { + fprintf(stderr, "r=%d\n", r); + return NULL; + } + + out = realloc(out, strm.total_out); + *size = strm.total_out; + + lzma_end(&strm); + + return out; +} +#endif + +/* ---------------------------------------------------------------------- + * CRAM blocks - the dynamically growable data block. We have code to + * create, update, (un)compress and read/write. + * + * These are derived from the deflate_interlaced.c blocks, but with the + * CRAM extension of content types and IDs. + */ + +/* + * Allocates a new cram_block structure with a specified content_type and + * id. + * + * Returns block pointer on success + * NULL on failure + */ +cram_block *cram_new_block(enum cram_content_type content_type, + int content_id) { + cram_block *b = malloc(sizeof(*b)); + if (!b) + return NULL; + b->method = b->orig_method = RAW; + b->content_type = content_type; + b->content_id = content_id; + b->comp_size = 0; + b->uncomp_size = 0; + b->data = NULL; + b->alloc = 0; + b->byte = 0; + b->bit = 7; // MSB + + return b; +} + +/* + * Reads a block from a cram file. + * Returns cram_block pointer on success. + * NULL on failure + */ +cram_block *cram_read_block(cram_fd *fd) { + cram_block *b = malloc(sizeof(*b)); + if (!b) + return NULL; + + //fprintf(stderr, "Block at %d\n", (int)ftell(fd->fp)); + + if (-1 == (b->method = hgetc(fd->fp))) { free(b); return NULL; } + if (-1 == (b->content_type= hgetc(fd->fp))) { free(b); return NULL; } + if (-1 == itf8_decode(fd, &b->content_id)) { free(b); return NULL; } + if (-1 == itf8_decode(fd, &b->comp_size)) { free(b); return NULL; } + if (-1 == itf8_decode(fd, &b->uncomp_size)) { free(b); return NULL; } + + // fprintf(stderr, " method %d, ctype %d, cid %d, csize %d, ucsize %d\n", + // b->method, b->content_type, b->content_id, b->comp_size, b->uncomp_size); + + if (b->method == RAW) { + b->alloc = b->uncomp_size; + if (!(b->data = malloc(b->uncomp_size))){ free(b); return NULL; } + if (b->uncomp_size != hread(fd->fp, b->data, b->uncomp_size)) { + free(b->data); + free(b); + return NULL; + } + } else { + b->alloc = b->comp_size; + if (!(b->data = malloc(b->comp_size))) { free(b); return NULL; } + if (b->comp_size != hread(fd->fp, b->data, b->comp_size)) { + free(b->data); + free(b); + return NULL; + } + } + + if (CRAM_MAJOR_VERS(fd->version) >= 3) { + unsigned char dat[100], *cp = dat;; + uint32_t crc; + + + if (-1 == int32_decode(fd, (int32_t *)&b->crc32)) { + free(b); + return NULL; + } + + *cp++ = b->method; + *cp++ = b->content_type; + cp += itf8_put(cp, b->content_id); + cp += itf8_put(cp, b->comp_size); + cp += itf8_put(cp, b->uncomp_size); + crc = crc32(0L, dat, cp-dat); + crc = crc32(crc, b->data ? b->data : (uc *)"", b->alloc); + + if (crc != b->crc32) { + fprintf(stderr, "Block CRC32 failure\n"); + free(b->data); + free(b); + return NULL; + } + } + + b->orig_method = b->method; + b->idx = 0; + b->byte = 0; + b->bit = 7; // MSB + + return b; +} + +/* + * Writes a CRAM block. + * Returns 0 on success + * -1 on failure + */ +int cram_write_block(cram_fd *fd, cram_block *b) { + assert(b->method != RAW || (b->comp_size == b->uncomp_size)); + + if (hputc(b->method, fd->fp) == EOF) return -1; + if (hputc(b->content_type, fd->fp) == EOF) return -1; + if (itf8_encode(fd, b->content_id) == -1) return -1; + if (itf8_encode(fd, b->comp_size) == -1) return -1; + if (itf8_encode(fd, b->uncomp_size) == -1) return -1; + + if (b->method == RAW) { + if (b->uncomp_size != hwrite(fd->fp, b->data, b->uncomp_size)) + return -1; + } else { + if (b->comp_size != hwrite(fd->fp, b->data, b->comp_size)) + return -1; + } + + if (CRAM_MAJOR_VERS(fd->version) >= 3) { + unsigned char dat[100], *cp = dat;; + uint32_t crc; + + *cp++ = b->method; + *cp++ = b->content_type; + cp += itf8_put(cp, b->content_id); + cp += itf8_put(cp, b->comp_size); + cp += itf8_put(cp, b->uncomp_size); + crc = crc32(0L, dat, cp-dat); + + if (b->method == RAW) { + b->crc32 = crc32(crc, b->data ? b->data : (uc*)"", b->uncomp_size); + } else { + b->crc32 = crc32(crc, b->data ? b->data : (uc*)"", b->comp_size); + } + + if (-1 == int32_encode(fd, b->crc32)) + return -1; + } + + return 0; +} + +/* + * Frees a CRAM block, deallocating internal data too. + */ +void cram_free_block(cram_block *b) { + if (!b) + return; + if (b->data) + free(b->data); + free(b); +} + +/* + * Uncompresses a CRAM block, if compressed. + */ +int cram_uncompress_block(cram_block *b) { + char *uncomp; + size_t uncomp_size = 0; + + if (b->uncomp_size == 0) { + // blank block + b->method = RAW; + return 0; + } + + switch (b->method) { + case RAW: + return 0; + + case GZIP: + uncomp = zlib_mem_inflate((char *)b->data, b->comp_size, &uncomp_size); + if (!uncomp) + return -1; + if ((int)uncomp_size != b->uncomp_size) { + free(uncomp); + return -1; + } + free(b->data); + b->data = (unsigned char *)uncomp; + b->alloc = uncomp_size; + b->method = RAW; + break; + +#ifdef HAVE_LIBBZ2 + case BZIP2: { + unsigned int usize = b->uncomp_size; + if (!(uncomp = malloc(usize))) + return -1; + if (BZ_OK != BZ2_bzBuffToBuffDecompress(uncomp, &usize, + (char *)b->data, b->comp_size, + 0, 0)) { + free(uncomp); + return -1; + } + free(b->data); + b->data = (unsigned char *)uncomp; + b->alloc = usize; + b->method = RAW; + b->uncomp_size = usize; // Just incase it differs + break; + } +#else + case BZIP2: + fprintf(stderr, "Bzip2 compression is not compiled into this " + "version.\nPlease rebuild and try again.\n"); + return -1; +#endif + +#ifdef HAVE_LIBLZMA + case LZMA: + uncomp = lzma_mem_inflate((char *)b->data, b->comp_size, &uncomp_size); + if (!uncomp) + return -1; + if ((int)uncomp_size != b->uncomp_size) + return -1; + free(b->data); + b->data = (unsigned char *)uncomp; + b->alloc = uncomp_size; + b->method = RAW; + break; +#else + case LZMA: + fprintf(stderr, "Lzma compression is not compiled into this " + "version.\nPlease rebuild and try again.\n"); + return -1; + break; +#endif + + case RANS: { + unsigned int usize = b->uncomp_size, usize2; + uncomp = (char *)rans_uncompress(b->data, b->comp_size, &usize2); + assert(usize == usize2); + free(b->data); + b->data = (unsigned char *)uncomp; + b->alloc = usize2; + b->method = RAW; + b->uncomp_size = usize2; // Just incase it differs + //fprintf(stderr, "Expanded %d to %d\n", b->comp_size, b->uncomp_size); + break; + } + + default: + return -1; + } + + return 0; +} + +static char *cram_compress_by_method(char *in, size_t in_size, + size_t *out_size, + enum cram_block_method method, + int level, int strat) { + switch (method) { + case GZIP: + return zlib_mem_deflate(in, in_size, out_size, level, strat); + + case BZIP2: { +#ifdef HAVE_LIBBZ2 + unsigned int comp_size = in_size*1.01 + 600; + char *comp = malloc(comp_size); + if (!comp) + return NULL; + + if (BZ_OK != BZ2_bzBuffToBuffCompress(comp, &comp_size, + in, in_size, + level, 0, 30)) { + free(comp); + return NULL; + } + *out_size = comp_size; + return comp; +#else + return NULL; +#endif + } + + case LZMA: +#ifdef HAVE_LIBLZMA + return lzma_mem_deflate(in, in_size, out_size, level); +#else + return NULL; +#endif + + case RANS0: { + unsigned int out_size_i; + unsigned char *cp; + cp = rans_compress((unsigned char *)in, in_size, &out_size_i, 0); + *out_size = out_size_i; + return (char *)cp; + } + + case RANS1: { + unsigned int out_size_i; + unsigned char *cp; + + cp = rans_compress((unsigned char *)in, in_size, &out_size_i, 1); + *out_size = out_size_i; + return (char *)cp; + } + + case RAW: + break; + + default: + return NULL; + } + + return NULL; +} + + +/* + * Compresses a block using one of two different zlib strategies. If we only + * want one choice set strat2 to be -1. + * + * The logic here is that sometimes Z_RLE does a better job than Z_FILTERED + * or Z_DEFAULT_STRATEGY on quality data. If so, we'd rather use it as it is + * significantly faster. + */ +int cram_compress_block(cram_fd *fd, cram_block *b, cram_metrics *metrics, + int method, int level) { + + char *comp = NULL; + size_t comp_size = 0; + int strat; + + //fprintf(stderr, "IN: block %d, sz %d\n", b->content_id, b->uncomp_size); + + if (method == RAW || level == 0 || b->uncomp_size == 0) { + b->method = RAW; + b->comp_size = b->uncomp_size; + //fprintf(stderr, "Skip block id %d\n", b->content_id); + return 0; + } + + if (metrics) { + pthread_mutex_lock(&fd->metrics_lock); + if (metrics->trial > 0 || --metrics->next_trial <= 0) { + size_t sz_best = INT_MAX; + size_t sz_gz_rle = 0; + size_t sz_gz_def = 0; + size_t sz_rans0 = 0; + size_t sz_rans1 = 0; + size_t sz_bzip2 = 0; + size_t sz_lzma = 0; + int method_best = 0; + char *c_best = NULL, *c = NULL; + + if (metrics->revised_method) + method = metrics->revised_method; + else + metrics->revised_method = method; + + if (metrics->next_trial == 0) { + metrics->next_trial = TRIAL_SPAN; + metrics->trial = NTRIALS; + metrics->sz_gz_rle /= 2; + metrics->sz_gz_def /= 2; + metrics->sz_rans0 /= 2; + metrics->sz_rans1 /= 2; + metrics->sz_bzip2 /= 2; + metrics->sz_lzma /= 2; + } + + pthread_mutex_unlock(&fd->metrics_lock); + + if (method & (1<<GZIP_RLE)) { + c = cram_compress_by_method((char *)b->data, b->uncomp_size, + &sz_gz_rle, GZIP, 1, Z_RLE); + if (c && sz_best > sz_gz_rle) { + sz_best = sz_gz_rle; + method_best = GZIP_RLE; + if (c_best) + free(c_best); + c_best = c; + } else if (c) { + free(c); + } else { + sz_gz_rle = b->uncomp_size*2+1000; + } + + //fprintf(stderr, "Block %d; %d->%d\n", b->content_id, b->uncomp_size, sz_gz_rle); + } + + if (method & (1<<GZIP)) { + c = cram_compress_by_method((char *)b->data, b->uncomp_size, + &sz_gz_def, GZIP, level, + Z_FILTERED); + if (c && sz_best > sz_gz_def) { + sz_best = sz_gz_def; + method_best = GZIP; + if (c_best) + free(c_best); + c_best = c; + } else if (c) { + free(c); + } else { + sz_gz_def = b->uncomp_size*2+1000; + } + + //fprintf(stderr, "Block %d; %d->%d\n", b->content_id, b->uncomp_size, sz_gz_def); + } + + if (method & (1<<RANS0)) { + c = cram_compress_by_method((char *)b->data, b->uncomp_size, + &sz_rans0, RANS0, 0, 0); + if (c && sz_best > sz_rans0) { + sz_best = sz_rans0; + method_best = RANS0; + if (c_best) + free(c_best); + c_best = c; + } else if (c) { + free(c); + } else { + sz_rans0 = b->uncomp_size*2+1000; + } + } + + if (method & (1<<RANS1)) { + c = cram_compress_by_method((char *)b->data, b->uncomp_size, + &sz_rans1, RANS1, 0, 0); + if (c && sz_best > sz_rans1) { + sz_best = sz_rans1; + method_best = RANS1; + if (c_best) + free(c_best); + c_best = c; + } else if (c) { + free(c); + } else { + sz_rans1 = b->uncomp_size*2+1000; + } + } + + if (method & (1<<BZIP2)) { + c = cram_compress_by_method((char *)b->data, b->uncomp_size, + &sz_bzip2, BZIP2, level, 0); + if (c && sz_best > sz_bzip2) { + sz_best = sz_bzip2; + method_best = BZIP2; + if (c_best) + free(c_best); + c_best = c; + } else if (c) { + free(c); + } else { + sz_bzip2 = b->uncomp_size*2+1000; + } + } + + if (method & (1<<LZMA)) { + c = cram_compress_by_method((char *)b->data, b->uncomp_size, + &sz_lzma, LZMA, level, 0); + if (c && sz_best > sz_lzma) { + sz_best = sz_lzma; + method_best = LZMA; + if (c_best) + free(c_best); + c_best = c; + } else if (c) { + free(c); + } else { + sz_lzma = b->uncomp_size*2+1000; + } + } + + //fprintf(stderr, "sz_best = %d\n", sz_best); + + free(b->data); + b->data = (unsigned char *)c_best; + //printf("method_best = %s\n", cram_block_method2str(method_best)); + b->method = method_best == GZIP_RLE ? GZIP : method_best; + b->comp_size = sz_best; + + pthread_mutex_lock(&fd->metrics_lock); + metrics->sz_gz_rle += sz_gz_rle; + metrics->sz_gz_def += sz_gz_def; + metrics->sz_rans0 += sz_rans0; + metrics->sz_rans1 += sz_rans1; + metrics->sz_bzip2 += sz_bzip2; + metrics->sz_lzma += sz_lzma; + if (--metrics->trial == 0) { + int best_method = RAW; + int best_sz = INT_MAX; + + // Scale methods by cost + if (fd->level <= 3) { + metrics->sz_rans1 *= 1.02; + metrics->sz_gz_def *= 1.04; + metrics->sz_bzip2 *= 1.08; + metrics->sz_lzma *= 1.10; + } else if (fd->level <= 6) { + metrics->sz_rans1 *= 1.01; + metrics->sz_gz_def *= 1.02; + metrics->sz_bzip2 *= 1.03; + metrics->sz_lzma *= 1.05; + } + + if (method & (1<<GZIP_RLE) && best_sz > metrics->sz_gz_rle) + best_sz = metrics->sz_gz_rle, best_method = GZIP_RLE; + + if (method & (1<<GZIP) && best_sz > metrics->sz_gz_def) + best_sz = metrics->sz_gz_def, best_method = GZIP; + + if (method & (1<<RANS0) && best_sz > metrics->sz_rans0) + best_sz = metrics->sz_rans0, best_method = RANS0; + + if (method & (1<<RANS1) && best_sz > metrics->sz_rans1) + best_sz = metrics->sz_rans1, best_method = RANS1; + + if (method & (1<<BZIP2) && best_sz > metrics->sz_bzip2) + best_sz = metrics->sz_bzip2, best_method = BZIP2; + + if (method & (1<<LZMA) && best_sz > metrics->sz_lzma) + best_sz = metrics->sz_lzma, best_method = LZMA; + + if (best_method == GZIP_RLE) { + metrics->method = GZIP; + metrics->strat = Z_RLE; + } else { + metrics->method = best_method; + metrics->strat = Z_FILTERED; + } + + // If we see at least MAXFAIL trials in a row for a specific + // compression method with more than MAXDELTA aggregate + // size then we drop this from the list of methods used + // for this block type. +#define MAXDELTA 0.20 +#define MAXFAILS 4 + if (best_method == GZIP_RLE) { + metrics->gz_rle_cnt = 0; + metrics->gz_rle_extra = 0; + } else if (best_sz < metrics->sz_gz_rle) { + double r = (double)metrics->sz_gz_rle / best_sz - 1; + if (++metrics->gz_rle_cnt >= MAXFAILS && + (metrics->gz_rle_extra += r) >= MAXDELTA) + method &= ~(1<<GZIP_RLE); + } + + if (best_method == GZIP) { + metrics->gz_def_cnt = 0; + metrics->gz_def_extra = 0; + } else if (best_sz < metrics->sz_gz_def) { + double r = (double)metrics->sz_gz_def / best_sz - 1; + if (++metrics->gz_def_cnt >= MAXFAILS && + (metrics->gz_def_extra += r) >= MAXDELTA) + method &= ~(1<<GZIP); + } + + if (best_method == RANS0) { + metrics->rans0_cnt = 0; + metrics->rans0_extra = 0; + } else if (best_sz < metrics->sz_rans0) { + double r = (double)metrics->sz_rans0 / best_sz - 1; + if (++metrics->rans0_cnt >= MAXFAILS && + (metrics->rans0_extra += r) >= MAXDELTA) + method &= ~(1<<RANS0); + } + + if (best_method == RANS1) { + metrics->rans1_cnt = 0; + metrics->rans1_extra = 0; + } else if (best_sz < metrics->sz_rans1) { + double r = (double)metrics->sz_rans1 / best_sz - 1; + if (++metrics->rans1_cnt >= MAXFAILS && + (metrics->rans1_extra += r) >= MAXDELTA) + method &= ~(1<<RANS1); + } + + if (best_method == BZIP2) { + metrics->bzip2_cnt = 0; + metrics->bzip2_extra = 0; + } else if (best_sz < metrics->sz_bzip2) { + double r = (double)metrics->sz_bzip2 / best_sz - 1; + if (++metrics->bzip2_cnt >= MAXFAILS && + (metrics->bzip2_extra += r) >= MAXDELTA) + method &= ~(1<<BZIP2); + } + + if (best_method == LZMA) { + metrics->lzma_cnt = 0; + metrics->lzma_extra = 0; + } else if (best_sz < metrics->sz_lzma) { + double r = (double)metrics->sz_lzma / best_sz - 1; + if (++metrics->lzma_cnt >= MAXFAILS && + (metrics->lzma_extra += r) >= MAXDELTA) + method &= ~(1<<LZMA); + } + + //if (method != metrics->revised_method) + // fprintf(stderr, "%d: method from %x to %x\n", + // b->content_id, metrics->revised_method, method); + metrics->revised_method = method; + } + pthread_mutex_unlock(&fd->metrics_lock); + } else { + strat = metrics->strat; + method = metrics->method; + + pthread_mutex_unlock(&fd->metrics_lock); + comp = cram_compress_by_method((char *)b->data, b->uncomp_size, + &comp_size, method, + level, strat); + if (!comp) + return -1; + free(b->data); + b->data = (unsigned char *)comp; + b->comp_size = comp_size; + b->method = method; + } + + } else { + // no cached metrics, so just do zlib? + comp = cram_compress_by_method((char *)b->data, b->uncomp_size, + &comp_size, GZIP, level, Z_FILTERED); + if (!comp) { + fprintf(stderr, "Compression failed!\n"); + return -1; + } + free(b->data); + b->data = (unsigned char *)comp; + b->comp_size = comp_size; + b->method = GZIP; + } + + if (fd->verbose) + fprintf(stderr, "Compressed block ID %d from %d to %d by method %s\n", + b->content_id, b->uncomp_size, b->comp_size, + cram_block_method2str(b->method)); + + if (b->method == RANS1) + b->method = RANS0; // Spec just has RANS (not 0/1) with auto-sensing + + return 0; +} + +cram_metrics *cram_new_metrics(void) { + cram_metrics *m = calloc(1, sizeof(*m)); + if (!m) + return NULL; + m->trial = NTRIALS-1; + m->next_trial = TRIAL_SPAN; + m->method = RAW; + m->strat = 0; + m->revised_method = 0; + + return m; +} + +char *cram_block_method2str(enum cram_block_method m) { + switch(m) { + case RAW: return "RAW"; + case GZIP: return "GZIP"; + case BZIP2: return "BZIP2"; + case LZMA: return "LZMA"; + case RANS0: return "RANS0"; + case RANS1: return "RANS1"; + case GZIP_RLE: return "GZIP_RLE"; + case ERROR: break; + } + return "?"; +} + +char *cram_content_type2str(enum cram_content_type t) { + switch (t) { + case FILE_HEADER: return "FILE_HEADER"; + case COMPRESSION_HEADER: return "COMPRESSION_HEADER"; + case MAPPED_SLICE: return "MAPPED_SLICE"; + case UNMAPPED_SLICE: return "UNMAPPED_SLICE"; + case EXTERNAL: return "EXTERNAL"; + case CORE: return "CORE"; + case CT_ERROR: break; + } + return "?"; +} + +/* + * Extra error checking on fclose to really ensure data is written. + * Care needs to be taken to handle pipes vs real files. + * + * Returns 0 on success + * -1 on failure. + */ +int paranoid_fclose(FILE *fp) { + if (-1 == fflush(fp) && errno != EBADF) { + fclose(fp); + return -1; + } + + errno = 0; + if (-1 == fsync(fileno(fp))) { + if (errno != EINVAL) { // eg pipe + fclose(fp); + return -1; + } + } + return fclose(fp); +} + +/* ---------------------------------------------------------------------- + * Reference sequence handling + * + * These revolve around the refs_t structure, which may potentially be + * shared between multiple cram_fd. + * + * We start with refs_create() to allocate an empty refs_t and then + * populate it with @SQ line data using refs_from_header(). This is done on + * cram_open(). Also at start up we can call cram_load_reference() which + * is used with "scramble -r foo.fa". This replaces the fd->refs with the + * new one specified. In either case refs2id() is then called which + * maps ref_entry names to @SQ ids (refs_t->ref_id[]). + * + * Later, possibly within a thread, we will want to know the actual ref + * seq itself, obtained by calling cram_get_ref(). This may use the + * UR: or M5: fields or the filename specified in the original + * cram_load_reference() call. + * + * Given the potential for multi-threaded reference usage, we have + * reference counting (sorry for the confusing double use of "ref") to + * track the number of callers interested in any specific reference. + */ + +void refs_free(refs_t *r) { + RP("refs_free()\n"); + + if (--r->count > 0) + return; + + if (!r) + return; + + if (r->pool) + string_pool_destroy(r->pool); + + if (r->h_meta) { + khint_t k; + + for (k = kh_begin(r->h_meta); k != kh_end(r->h_meta); k++) { + ref_entry *e; + + if (!kh_exist(r->h_meta, k)) + continue; + if (!(e = kh_val(r->h_meta, k))) + continue; + if (e->seq) + free(e->seq); + free(e); + } + + kh_destroy(refs, r->h_meta); + } + + if (r->ref_id) + free(r->ref_id); + + if (r->fp) + bgzf_close(r->fp); + + pthread_mutex_destroy(&r->lock); + + free(r); +} + +static refs_t *refs_create(void) { + refs_t *r = calloc(1, sizeof(*r)); + + RP("refs_create()\n"); + + if (!r) + return NULL; + + if (!(r->pool = string_pool_create(8192))) + goto err; + + r->ref_id = NULL; // see refs2id() to populate. + r->count = 1; + r->last = NULL; + r->last_id = -1; + + if (!(r->h_meta = kh_init(refs))) + goto err; + + pthread_mutex_init(&r->lock, NULL); + + return r; + + err: + refs_free(r); + return NULL; +} + +/* + * Opens a reference fasta file as a BGZF stream, allowing for + * compressed files. It automatically builds a .fai file if + * required and if compressed a .gzi bgzf index too. + * + * Returns a BGZF handle on success; + * NULL on failure. + */ +static BGZF *bgzf_open_ref(char *fn, char *mode) { + BGZF *fp; + char fai_file[PATH_MAX]; + + snprintf(fai_file, PATH_MAX, "%s.fai", fn); + if (access(fai_file, R_OK) != 0) + if (fai_build(fn) != 0) + return NULL; + + if (!(fp = bgzf_open(fn, mode))) { + perror(fn); + return NULL; + } + + if (fp->is_compressed == 1 && bgzf_index_load(fp, fn, ".gzi") < 0) { + fprintf(stderr, "Unable to load .gzi index '%s.gzi'\n", fn); + bgzf_close(fp); + return NULL; + } + + return fp; +} + +/* + * Loads a FAI file for a reference.fasta. + * "is_err" indicates whether failure to load is worthy of emitting an + * error message. In some cases (eg with embedded references) we + * speculatively load, just incase, and silently ignore errors. + * + * Returns the refs_t struct on success (maybe newly allocated); + * NULL on failure + */ +static refs_t *refs_load_fai(refs_t *r_orig, char *fn, int is_err) { + struct stat sb; + FILE *fp = NULL; + char fai_fn[PATH_MAX]; + char line[8192]; + refs_t *r = r_orig; + size_t fn_l = strlen(fn); + int id = 0, id_alloc = 0; + + RP("refs_load_fai %s\n", fn); + + if (!r) + if (!(r = refs_create())) + goto err; + + /* Open reference, for later use */ + if (stat(fn, &sb) != 0) { + if (is_err) + perror(fn); + goto err; + } + + if (r->fp) + if (bgzf_close(r->fp) != 0) + goto err; + r->fp = NULL; + + if (!(r->fn = string_dup(r->pool, fn))) + goto err; + + if (fn_l > 4 && strcmp(&fn[fn_l-4], ".fai") == 0) + r->fn[fn_l-4] = 0; + + if (!(r->fp = bgzf_open_ref(r->fn, "r"))) + goto err; + + /* Parse .fai file and load meta-data */ + sprintf(fai_fn, "%.*s.fai", PATH_MAX-5, r->fn); + + if (stat(fai_fn, &sb) != 0) { + if (is_err) + perror(fai_fn); + goto err; + } + if (!(fp = fopen(fai_fn, "r"))) { + if (is_err) + perror(fai_fn); + goto err; + } + while (fgets(line, 8192, fp) != NULL) { + ref_entry *e = malloc(sizeof(*e)); + char *cp; + int n; + khint_t k; + + if (!e) + return NULL; + + // id + for (cp = line; *cp && !isspace(*cp); cp++) + ; + *cp++ = 0; + e->name = string_dup(r->pool, line); + + // length + while (*cp && isspace(*cp)) + cp++; + e->length = strtoll(cp, &cp, 10); + + // offset + while (*cp && isspace(*cp)) + cp++; + e->offset = strtoll(cp, &cp, 10); + + // bases per line + while (*cp && isspace(*cp)) + cp++; + e->bases_per_line = strtol(cp, &cp, 10); + + // line length + while (*cp && isspace(*cp)) + cp++; + e->line_length = strtol(cp, &cp, 10); + + // filename + e->fn = r->fn; + + e->count = 0; + e->seq = NULL; + + k = kh_put(refs, r->h_meta, e->name, &n); + if (-1 == n) { + free(e); + return NULL; + } + + if (n) { + kh_val(r->h_meta, k) = e; + } else { + ref_entry *re = kh_val(r->h_meta, k); + if (re && (re->count != 0 || re->length != 0)) { + /* Keep old */ + free(e); + } else { + /* Replace old */ + if (re) + free(re); + kh_val(r->h_meta, k) = e; + } + } + + if (id >= id_alloc) { + int x; + + id_alloc = id_alloc ?id_alloc*2 : 16; + r->ref_id = realloc(r->ref_id, id_alloc * sizeof(*r->ref_id)); + + for (x = id; x < id_alloc; x++) + r->ref_id[x] = NULL; + } + r->ref_id[id] = e; + r->nref = ++id; + } + + return r; + + err: + if (fp) + fclose(fp); + + if (!r_orig) + refs_free(r); + + return NULL; +} + +/* + * Indexes references by the order they appear in a BAM file. This may not + * necessarily be the same order they appear in the fasta reference file. + * + * Returns 0 on success + * -1 on failure + */ +int refs2id(refs_t *r, SAM_hdr *h) { + int i; + + if (r->ref_id) + free(r->ref_id); + if (r->last) + r->last = NULL; + + r->ref_id = calloc(h->nref, sizeof(*r->ref_id)); + if (!r->ref_id) + return -1; + + r->nref = h->nref; + for (i = 0; i < h->nref; i++) { + khint_t k = kh_get(refs, r->h_meta, h->ref[i].name); + if (k != kh_end(r->h_meta)) { + r->ref_id[i] = kh_val(r->h_meta, k); + } else { + fprintf(stderr, "Unable to find ref name '%s'\n", + h->ref[i].name); + } + } + + return 0; +} + +/* + * Generates refs_t entries based on @SQ lines in the header. + * Returns 0 on success + * -1 on failure + */ +static int refs_from_header(refs_t *r, cram_fd *fd, SAM_hdr *h) { + int i, j; + + if (!h || h->nref == 0) + return 0; + + //fprintf(stderr, "refs_from_header for %p mode %c\n", fd, fd->mode); + + /* Existing refs are fine, as long as they're compatible with the hdr. */ + if (!(r->ref_id = realloc(r->ref_id, (r->nref + h->nref) * sizeof(*r->ref_id)))) + return -1; + + /* Copy info from h->ref[i] over to r */ + for (i = 0, j = r->nref; i < h->nref; i++) { + SAM_hdr_type *ty; + SAM_hdr_tag *tag; + khint_t k; + int n; + + k = kh_get(refs, r->h_meta, h->ref[i].name); + if (k != kh_end(r->h_meta)) + // Ref already known about + continue; + + if (!(r->ref_id[j] = calloc(1, sizeof(ref_entry)))) + return -1; + + if (!h->ref[j].name) + return -1; + + r->ref_id[j]->name = string_dup(r->pool, h->ref[i].name); + r->ref_id[j]->length = 0; // marker for not yet loaded + + /* Initialise likely filename if known */ + if ((ty = sam_hdr_find(h, "SQ", "SN", h->ref[i].name))) { + if ((tag = sam_hdr_find_key(h, ty, "M5", NULL))) { + r->ref_id[j]->fn = string_dup(r->pool, tag->str+3); + //fprintf(stderr, "Tagging @SQ %s / %s\n", r->ref_id[h]->name, r->ref_id[h]->fn); + } + } + + k = kh_put(refs, r->h_meta, r->ref_id[j]->name, &n); + if (n <= 0) // already exists or error + return -1; + kh_val(r->h_meta, k) = r->ref_id[j]; + + j++; + } + r->nref = j; + + return 0; +} + +/* + * Attaches a header to a cram_fd. + * + * This should be used when creating a new cram_fd for writing where + * we have an SAM_hdr already constructed (eg from a file we've read + * in). + */ +int cram_set_header(cram_fd *fd, SAM_hdr *hdr) { + if (fd->header) + sam_hdr_free(fd->header); + fd->header = hdr; + return refs_from_header(fd->refs, fd, hdr); +} + +/* + * Converts a directory and a filename into an expanded path, replacing %s + * in directory with the filename and %[0-9]+s with portions of the filename + * Any remaining parts of filename are added to the end with /%s. + */ +void expand_cache_path(char *path, char *dir, char *fn) { + char *cp; + + while ((cp = strchr(dir, '%'))) { + strncpy(path, dir, cp-dir); + path += cp-dir; + + if (*++cp == 's') { + strcpy(path, fn); + path += strlen(fn); + fn += strlen(fn); + cp++; + } else if (*cp >= '0' && *cp <= '9') { + char *endp; + long l; + + l = strtol(cp, &endp, 10); + l = MIN(l, strlen(fn)); + if (*endp == 's') { + strncpy(path, fn, l); + path += l; + fn += l; + *path = 0; + cp = endp+1; + } else { + *path++ = '%'; + *path++ = *cp++; + } + } else { + *path++ = '%'; + *path++ = *cp++; + } + dir = cp; + } + strcpy(path, dir); + path += strlen(dir); + if (*fn && path[-1] != '/') + *path++ = '/'; + strcpy(path, fn); +} + +/* + * Make the directory containing path and any prefix directories. + */ +void mkdir_prefix(char *path, int mode) { + char *cp = strrchr(path, '/'); + if (!cp) + return; + + *cp = 0; + if (is_directory(path)) { + *cp = '/'; + return; + } + + if (mkdir(path, mode) == 0) { + chmod(path, mode); + *cp = '/'; + return; + } + + mkdir_prefix(path, mode); + mkdir(path, mode); + chmod(path, mode); + *cp = '/'; +} + +/* + * Return the cache directory to use, based on the first of these + * environment variables to be set to a non-empty value. + */ +static const char *get_cache_basedir(const char **extra) { + char *base; + + *extra = ""; + + base = getenv("XDG_CACHE_HOME"); + if (base && *base) return base; + + base = getenv("HOME"); + if (base && *base) { *extra = "/.cache"; return base; } + + base = getenv("TMPDIR"); + if (base && *base) return base; + + base = getenv("TEMP"); + if (base && *base) return base; + + return "/tmp"; +} + +/* + * Queries the M5 string from the header and attempts to populate the + * reference from this using the REF_PATH environment. + * + * Returns 0 on sucess + * -1 on failure + */ +static int cram_populate_ref(cram_fd *fd, int id, ref_entry *r) { + char *ref_path = getenv("REF_PATH"); + SAM_hdr_type *ty; + SAM_hdr_tag *tag; + char path[PATH_MAX], path_tmp[PATH_MAX], cache[PATH_MAX]; + char *local_cache = getenv("REF_CACHE"); + mFILE *mf; + + if (fd->verbose) + fprintf(stderr, "cram_populate_ref on fd %p, id %d\n", fd, id); + + if (!ref_path || *ref_path == '\0') { + /* + * If we have no ref path, we use the EBI server. + * However to avoid spamming it we require a local ref cache too. + */ + ref_path = "http://www.ebi.ac.uk:80/ena/cram/md5/%s"; + if (!local_cache || *local_cache == '\0') { + const char *extra; + const char *base = get_cache_basedir(&extra); + snprintf(cache,PATH_MAX, "%s%s/hts-ref/%%2s/%%2s/%%s", base, extra); + local_cache = cache; + if (fd->verbose) + fprintf(stderr, "Populating local cache: %s\n", local_cache); + } + } + + if (!r->name) + return -1; + + if (!(ty = sam_hdr_find(fd->header, "SQ", "SN", r->name))) + return -1; + + if (!(tag = sam_hdr_find_key(fd->header, ty, "M5", NULL))) + goto no_M5; + + if (fd->verbose) + fprintf(stderr, "Querying ref %s\n", tag->str+3); + + /* Use cache if available */ + if (local_cache && *local_cache) { + struct stat sb; + BGZF *fp; + + expand_cache_path(path, local_cache, tag->str+3); + + if (0 == stat(path, &sb) && (fp = bgzf_open(path, "r"))) { + r->length = sb.st_size; + r->offset = r->line_length = r->bases_per_line = 0; + + r->fn = string_dup(fd->refs->pool, path); + + if (fd->refs->fp) + if (bgzf_close(fd->refs->fp) != 0) + return -1; + fd->refs->fp = fp; + fd->refs->fn = r->fn; + + // Fall back to cram_get_ref() where it'll do the actual + // reading of the file. + return 0; + } + } + + /* Otherwise search */ + if ((mf = open_path_mfile(tag->str+3, ref_path, NULL))) { + size_t sz; + r->seq = mfsteal(mf, &sz); + r->length = sz; + } else { + refs_t *refs; + char *fn; + + no_M5: + /* Failed to find in search path or M5 cache, see if @SQ UR: tag? */ + if (!(tag = sam_hdr_find_key(fd->header, ty, "UR", NULL))) + return -1; + + fn = (strncmp(tag->str+3, "file:", 5) == 0) + ? tag->str+8 + : tag->str+3; + + if (fd->refs->fp) { + if (bgzf_close(fd->refs->fp) != 0) + return -1; + fd->refs->fp = NULL; + } + if (!(refs = refs_load_fai(fd->refs, fn, 0))) + return -1; + fd->refs = refs; + if (fd->refs->fp) { + if (bgzf_close(fd->refs->fp) != 0) + return -1; + fd->refs->fp = NULL; + } + + if (!fd->refs->fn) + return -1; + + if (-1 == refs2id(fd->refs, fd->header)) + return -1; + if (!fd->refs->ref_id || !fd->refs->ref_id[id]) + return -1; + + // Local copy already, so fall back to cram_get_ref(). + return 0; + } + + /* Populate the local disk cache if required */ + if (local_cache && *local_cache) { + FILE *fp; + int i; + + expand_cache_path(path, local_cache, tag->str+3); + if (fd->verbose) + fprintf(stderr, "Path='%s'\n", path); + mkdir_prefix(path, 01777); + + i = 0; + do { + sprintf(path_tmp, "%s.tmp_%d", path, /*getpid(),*/ i); + i++; + fp = fopen(path_tmp, "wx"); + } while (fp == NULL && errno == EEXIST); + if (!fp) { + perror(path_tmp); + + // Not fatal - we have the data already so keep going. + return 0; + } + + if (r->length != fwrite(r->seq, 1, r->length, fp)) { + perror(path); + } + if (-1 == paranoid_fclose(fp)) { + unlink(path_tmp); + } else { + if (0 == chmod(path_tmp, 0444)) + rename(path_tmp, path); + else + unlink(path_tmp); + } + } + + return 0; +} + +static void cram_ref_incr_locked(refs_t *r, int id) { + RP("%d INC REF %d, %d %p\n", gettid(), id, (int)(id>=0?r->ref_id[id]->count+1:-999), id>=0?r->ref_id[id]->seq:(char *)1); + + if (id < 0 || !r->ref_id[id]->seq) + return; + + if (r->last_id == id) + r->last_id = -1; + + ++r->ref_id[id]->count; +} + +void cram_ref_incr(refs_t *r, int id) { + pthread_mutex_lock(&r->lock); + cram_ref_incr_locked(r, id); + pthread_mutex_unlock(&r->lock); +} + +static void cram_ref_decr_locked(refs_t *r, int id) { + RP("%d DEC REF %d, %d %p\n", gettid(), id, (int)(id>=0?r->ref_id[id]->count-1:-999), id>=0?r->ref_id[id]->seq:(char *)1); + + if (id < 0 || !r->ref_id[id]->seq) { + assert(r->ref_id[id]->count >= 0); + return; + } + + if (--r->ref_id[id]->count <= 0) { + assert(r->ref_id[id]->count == 0); + if (r->last_id >= 0) { + if (r->ref_id[r->last_id]->count <= 0 && + r->ref_id[r->last_id]->seq) { + RP("%d FREE REF %d (%p)\n", gettid(), + r->last_id, r->ref_id[r->last_id]->seq); + free(r->ref_id[r->last_id]->seq); + r->ref_id[r->last_id]->seq = NULL; + r->ref_id[r->last_id]->length = 0; + } + } + r->last_id = id; + } +} + +void cram_ref_decr(refs_t *r, int id) { + pthread_mutex_lock(&r->lock); + cram_ref_decr_locked(r, id); + pthread_mutex_unlock(&r->lock); +} + +/* + * Used by cram_ref_load and cram_ref_get. The file handle will have + * already been opened, so we can catch it. The ref_entry *e informs us + * of whether this is a multi-line fasta file or a raw MD5 style file. + * Either way we create a single contiguous sequence. + * + * Returns all or part of a reference sequence on success (malloced); + * NULL on failure. + */ +static char *load_ref_portion(BGZF *fp, ref_entry *e, int start, int end) { + off_t offset, len; + char *seq; + + if (end < start) + end = start; + + /* + * Compute locations in file. This is trivial for the MD5 files, but + * is still necessary for the fasta variants. + */ + offset = e->line_length + ? e->offset + (start-1)/e->bases_per_line * e->line_length + + (start-1) % e->bases_per_line + : start-1; + + len = (e->line_length + ? e->offset + (end-1)/e->bases_per_line * e->line_length + + (end-1) % e->bases_per_line + : end-1) - offset + 1; + + if (bgzf_useek(fp, offset, SEEK_SET) < 0) { + perror("bgzf_useek() on reference file"); + return NULL; + } + + if (len == 0 || !(seq = malloc(len))) { + return NULL; + } + + if (len != bgzf_read(fp, seq, len)) { + perror("bgzf_read() on reference file"); + free(seq); + return NULL; + } + + /* Strip white-space if required. */ + if (len != end-start+1) { + int i, j; + char *cp = seq; + char *cp_to; + + for (i = j = 0; i < len; i++) { + if (cp[i] >= '!' && cp[i] <= '~') + cp[j++] = cp[i] & ~0x20; + } + cp_to = cp+j; + + if (cp_to - seq != end-start+1) { + fprintf(stderr, "Malformed reference file?\n"); + free(seq); + return NULL; + } + } else { + int i; + for (i = 0; i < len; i++) { + seq[i] = seq[i] & ~0x20; // uppercase in ASCII + } + } + + return seq; +} + +/* + * Load the entire reference 'id'. + * This also increments the reference count by 1. + * + * Returns ref_entry on success; + * NULL on failure + */ +ref_entry *cram_ref_load(refs_t *r, int id) { + ref_entry *e = r->ref_id[id]; + int start = 1, end = e->length; + char *seq; + + if (e->seq) { + return e; + } + + assert(e->count == 0); + + if (r->last) { +#ifdef REF_DEBUG + int idx = 0; + for (idx = 0; idx < r->nref; idx++) + if (r->last == r->ref_id[idx]) + break; + RP("%d cram_ref_load DECR %d\n", gettid(), idx); +#endif + assert(r->last->count > 0); + if (--r->last->count <= 0) { + RP("%d FREE REF %d (%p)\n", gettid(), id, r->ref_id[id]->seq); + if (r->last->seq) { + free(r->last->seq); + r->last->seq = NULL; + } + } + } + + /* Open file if it's not already the current open reference */ + if (strcmp(r->fn, e->fn) || r->fp == NULL) { + if (r->fp) + if (bgzf_close(r->fp) != 0) + return NULL; + r->fn = e->fn; + if (!(r->fp = bgzf_open_ref(r->fn, "r"))) + return NULL; + } + + RP("%d Loading ref %d (%d..%d)\n", gettid(), id, start, end); + + if (!(seq = load_ref_portion(r->fp, e, start, end))) { + return NULL; + } + + RP("%d Loaded ref %d (%d..%d) = %p\n", gettid(), id, start, end, seq); + + RP("%d INC REF %d, %d\n", gettid(), id, (int)(e->count+1)); + e->seq = seq; + e->count++; + + /* + * Also keep track of last used ref so incr/decr loops on the same + * sequence don't cause load/free loops. + */ + RP("%d cram_ref_load INCR %d => %d\n", gettid(), id, e->count+1); + r->last = e; + e->count++; + + return e; +} + +/* + * Returns a portion of a reference sequence from start to end inclusive. + * The returned pointer is owned by either the cram_file fd or by the + * internal refs_t structure and should not be freed by the caller. + * + * The difference is whether or not this refs_t is in use by just the one + * cram_fd or by multiples, or whether we have multiple threads accessing + * references. In either case fd->shared will be true and we start using + * reference counting to track the number of users of a specific reference + * sequence. + * + * Otherwise the ref seq returned is allocated as part of cram_fd itself + * and will be freed up on the next call to cram_get_ref or cram_close. + * + * To return the entire reference sequence, specify start as 1 and end + * as 0. + * + * To cease using a reference, call cram_ref_decr(). + * + * Returns reference on success, + * NULL on failure + */ +char *cram_get_ref(cram_fd *fd, int id, int start, int end) { + ref_entry *r; + char *seq; + int ostart = start; + + if (id == -1) + return NULL; + + /* FIXME: axiomatic query of r->seq being true? + * Or shortcut for unsorted data where we load once and never free? + */ + + //fd->shared_ref = 1; // hard code for now to simplify things + + pthread_mutex_lock(&fd->ref_lock); + + RP("%d cram_get_ref on fd %p, id %d, range %d..%d\n", gettid(), fd, id, start, end); + + /* + * Unsorted data implies we want to fetch an entire reference at a time. + * We just deal with this at the moment by claiming we're sharing + * references instead, which has the same requirement. + */ + if (fd->unsorted) + fd->shared_ref = 1; + + + /* Sanity checking: does this ID exist? */ + if (id >= fd->refs->nref) { + fprintf(stderr, "No reference found for id %d\n", id); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + + if (!fd->refs || !fd->refs->ref_id[id]) { + fprintf(stderr, "No reference found for id %d\n", id); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + + if (!(r = fd->refs->ref_id[id])) { + fprintf(stderr, "No reference found for id %d\n", id); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + + + /* + * It has an entry, but may not have been populated yet. + * Any manually loaded .fai files have their lengths known. + * A ref entry computed from @SQ lines (M5 or UR field) will have + * r->length == 0 unless it's been loaded once and verified that we have + * an on-disk filename for it. + * + * 19 Sep 2013: Moved the lock here as the cram_populate_ref code calls + * open_path_mfile and libcurl, which isn't multi-thread safe unless I + * rewrite my code to have one curl handle per thread. + */ + pthread_mutex_lock(&fd->refs->lock); + if (r->length == 0) { + if (cram_populate_ref(fd, id, r) == -1) { + fprintf(stderr, "Failed to populate reference for id %d\n", id); + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + r = fd->refs->ref_id[id]; + if (fd->unsorted) + cram_ref_incr_locked(fd->refs, id); + } + + + /* + * We now know that we the filename containing the reference, so check + * for limits. If it's over half the reference we'll load all of it in + * memory as this will speed up subsequent calls. + */ + if (end < 1) + end = r->length; + if (end >= r->length) + end = r->length; + assert(start >= 1); + + if (end - start >= 0.5*r->length || fd->shared_ref) { + start = 1; + end = r->length; + } + + /* + * Maybe we have it cached already? If so use it. + * + * Alternatively if we don't have the sequence but we're sharing + * references and/or are asking for the entire length of it, then + * load the full reference into the refs structure and return + * a pointer to that one instead. + */ + if (fd->shared_ref || r->seq || (start == 1 && end == r->length)) { + char *cp; + + if (id >= 0) { + if (r->seq) { + cram_ref_incr_locked(fd->refs, id); + } else { + ref_entry *e; + if (!(e = cram_ref_load(fd->refs, id))) { + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + + /* unsorted data implies cache ref indefinitely, to avoid + * continually loading and unloading. + */ + if (fd->unsorted) + cram_ref_incr_locked(fd->refs, id); + } + + fd->ref = NULL; /* We never access it directly */ + fd->ref_start = 1; + fd->ref_end = r->length; + fd->ref_id = id; + + cp = fd->refs->ref_id[id]->seq + ostart-1; + } else { + fd->ref = NULL; + cp = NULL; + } + + RP("%d cram_get_ref returning for id %d, count %d\n", gettid(), id, (int)r->count); + + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + return cp; + } + + /* + * Otherwise we're not sharing, we don't have a copy of it already and + * we're only asking for a small portion of it. + * + * In this case load up just that segment ourselves, freeing any old + * small segments in the process. + */ + + /* Unmapped ref ID */ + if (id < 0) { + if (fd->ref_free) { + free(fd->ref_free); + fd->ref_free = NULL; + } + fd->ref = NULL; + fd->ref_id = id; + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + + /* Open file if it's not already the current open reference */ + if (strcmp(fd->refs->fn, r->fn) || fd->refs->fp == NULL) { + if (fd->refs->fp) + if (bgzf_close(fd->refs->fp) != 0) + return NULL; + fd->refs->fn = r->fn; + if (!(fd->refs->fp = bgzf_open_ref(fd->refs->fn, "r"))) { + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + } + + if (!(fd->ref = load_ref_portion(fd->refs->fp, r, start, end))) { + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + return NULL; + } + + if (fd->ref_free) + free(fd->ref_free); + + fd->ref_id = id; + fd->ref_start = start; + fd->ref_end = end; + fd->ref_free = fd->ref; + seq = fd->ref; + + pthread_mutex_unlock(&fd->refs->lock); + pthread_mutex_unlock(&fd->ref_lock); + + return seq + ostart - start; +} + +/* + * If fd has been opened for reading, it may be permitted to specify 'fn' + * as NULL and let the code auto-detect the reference by parsing the + * SAM header @SQ lines. + */ +int cram_load_reference(cram_fd *fd, char *fn) { + if (fn) { + fd->refs = refs_load_fai(fd->refs, fn, + !(fd->embed_ref && fd->mode == 'r')); + fn = fd->refs ? fd->refs->fn : NULL; + } + fd->ref_fn = fn; + + if ((!fd->refs || (fd->refs->nref == 0 && !fn)) && fd->header) { + if (fd->refs) + refs_free(fd->refs); + if (!(fd->refs = refs_create())) + return -1; + if (-1 == refs_from_header(fd->refs, fd, fd->header)) + return -1; + } + + if (fd->header) + if (-1 == refs2id(fd->refs, fd->header)) + return -1; + + return fn ? 0 : -1; +} + +/* ---------------------------------------------------------------------- + * Containers + */ + +/* + * Creates a new container, specifying the maximum number of slices + * and records permitted. + * + * Returns cram_container ptr on success + * NULL on failure + */ +cram_container *cram_new_container(int nrec, int nslice) { + cram_container *c = calloc(1, sizeof(*c)); + enum cram_DS_ID id; + + if (!c) + return NULL; + + c->curr_ref = -2; + + c->max_c_rec = nrec * nslice; + c->curr_c_rec = 0; + + c->max_rec = nrec; + c->record_counter = 0; + c->num_bases = 0; + + c->max_slice = nslice; + c->curr_slice = 0; + + c->pos_sorted = 1; + c->max_apos = 0; + c->multi_seq = 0; + + c->bams = NULL; + + if (!(c->slices = (cram_slice **)calloc(nslice, sizeof(cram_slice *)))) + goto err; + c->slice = NULL; + + if (!(c->comp_hdr = cram_new_compression_header())) + goto err; + c->comp_hdr_block = NULL; + + for (id = DS_RN; id < DS_TN; id++) + if (!(c->stats[id] = cram_stats_create())) goto err; + + //c->aux_B_stats = cram_stats_create(); + + if (!(c->tags_used = kh_init(s_i2i))) + goto err; + c->refs_used = 0; + + return c; + + err: + if (c) { + if (c->slices) + free(c->slices); + free(c); + } + return NULL; +} + +void cram_free_container(cram_container *c) { + enum cram_DS_ID id; + int i; + + if (!c) + return; + + if (c->refs_used) + free(c->refs_used); + + if (c->landmark) + free(c->landmark); + + if (c->comp_hdr) + cram_free_compression_header(c->comp_hdr); + + if (c->comp_hdr_block) + cram_free_block(c->comp_hdr_block); + + if (c->slices) { + for (i = 0; i < c->max_slice; i++) + if (c->slices[i]) + cram_free_slice(c->slices[i]); + free(c->slices); + } + + for (id = DS_RN; id < DS_TN; id++) + if (c->stats[id]) cram_stats_free(c->stats[id]); + + //if (c->aux_B_stats) cram_stats_free(c->aux_B_stats); + + if (c->tags_used) kh_destroy(s_i2i, c->tags_used); + + free(c); +} + +/* + * Reads a container header. + * + * Returns cram_container on success + * NULL on failure or no container left (fd->err == 0). + */ +cram_container *cram_read_container(cram_fd *fd) { + cram_container c2, *c; + int i, s; + size_t rd = 0; + + fd->err = 0; + fd->eof = 0; + + memset(&c2, 0, sizeof(c2)); + if (CRAM_MAJOR_VERS(fd->version) == 1) { + if ((s = itf8_decode(fd, &c2.length)) == -1) { + fd->eof = fd->empty_container ? 1 : 2; + return NULL; + } else { + rd+=s; + } + } else { + if ((s = int32_decode(fd, &c2.length)) == -1) { + if (CRAM_MAJOR_VERS(fd->version) == 2 && + CRAM_MINOR_VERS(fd->version) == 0) + fd->eof = 1; // EOF blocks arrived in v2.1 + else + fd->eof = fd->empty_container ? 1 : 2; + return NULL; + } else { + rd+=s; + } + } + if ((s = itf8_decode(fd, &c2.ref_seq_id)) == -1) return NULL; else rd+=s; + if ((s = itf8_decode(fd, &c2.ref_seq_start))== -1) return NULL; else rd+=s; + if ((s = itf8_decode(fd, &c2.ref_seq_span)) == -1) return NULL; else rd+=s; + if ((s = itf8_decode(fd, &c2.num_records)) == -1) return NULL; else rd+=s; + + if (CRAM_MAJOR_VERS(fd->version) == 1) { + c2.record_counter = 0; + c2.num_bases = 0; + } else { + if (CRAM_MAJOR_VERS(fd->version) >= 3) { + if ((s = ltf8_decode(fd, &c2.record_counter)) == -1) + return NULL; + else + rd += s; + } else { + int32_t i32; + if ((s = itf8_decode(fd, &i32)) == -1) + return NULL; + else + rd += s; + c2.record_counter = i32; + } + + if ((s = ltf8_decode(fd, &c2.num_bases))== -1) + return NULL; + else + rd += s; + } + if ((s = itf8_decode(fd, &c2.num_blocks)) == -1) return NULL; else rd+=s; + if ((s = itf8_decode(fd, &c2.num_landmarks))== -1) return NULL; else rd+=s; + + if (!(c = calloc(1, sizeof(*c)))) + return NULL; + + *c = c2; + + if (!(c->landmark = malloc(c->num_landmarks * sizeof(int32_t))) && + c->num_landmarks) { + fd->err = errno; + cram_free_container(c); + return NULL; + } + for (i = 0; i < c->num_landmarks; i++) { + if ((s = itf8_decode(fd, &c->landmark[i])) == -1) { + cram_free_container(c); + return NULL; + } else { + rd += s; + } + } + + if (CRAM_MAJOR_VERS(fd->version) >= 3) { + uint32_t crc, i; + unsigned char *dat = malloc(50 + 5*(c->num_landmarks)), *cp = dat; + if (!dat) { + cram_free_container(c); + return NULL; + } + if (-1 == int32_decode(fd, (int32_t *)&c->crc32)) + return NULL; + else + rd+=4; + + /* Reencode first as we can't easily access the original byte stream. + * + * FIXME: Technically this means this may not be fool proof. We could + * create a CRAM file using a 2 byte ITF8 value that can fit in a + * 1 byte field, meaning the encoding is different to the original + * form and so has a different CRC. + * + * The correct implementation would be to have an alternative form + * of itf8_decode which also squirrels away the raw byte stream + * during decoding so we can then CRC that. + */ + *(unsigned int *)cp = le_int4(c->length); cp += 4; + cp += itf8_put(cp, c->ref_seq_id); + cp += itf8_put(cp, c->ref_seq_start); + cp += itf8_put(cp, c->ref_seq_span); + cp += itf8_put(cp, c->num_records); + cp += ltf8_put((char *)cp, c->record_counter); + cp += itf8_put(cp, c->num_bases); + cp += itf8_put(cp, c->num_blocks); + cp += itf8_put(cp, c->num_landmarks); + for (i = 0; i < c->num_landmarks; i++) { + cp += itf8_put(cp, c->landmark[i]); + } + + crc = crc32(0L, dat, cp-dat); + if (crc != c->crc32) { + fprintf(stderr, "Container header CRC32 failure\n"); + cram_free_container(c); + return NULL; + } + } + + c->offset = rd; + c->slices = NULL; + c->curr_slice = 0; + c->max_slice = c->num_landmarks; + c->slice_rec = 0; + c->curr_rec = 0; + c->max_rec = 0; + + if (c->ref_seq_id == -2) { + c->multi_seq = 1; + fd->multi_seq = 1; + } + + fd->empty_container = + (c->num_records == 0 && + c->ref_seq_id == -1 && + c->ref_seq_start == 0x454f46 /* EOF */) ? 1 : 0; + + return c; +} + +/* + * Writes a container structure. + * + * Returns 0 on success + * -1 on failure + */ +int cram_write_container(cram_fd *fd, cram_container *c) { + char buf_a[1024], *buf = buf_a, *cp; + int i; + + if (55 + c->num_landmarks * 5 >= 1024) + buf = malloc(55 + c->num_landmarks * 5); + cp = buf; + + if (CRAM_MAJOR_VERS(fd->version) == 1) { + cp += itf8_put(cp, c->length); + } else { + *(int32_t *)cp = le_int4(c->length); + cp += 4; + } + if (c->multi_seq) { + cp += itf8_put(cp, -2); + cp += itf8_put(cp, 0); + cp += itf8_put(cp, 0); + } else { + cp += itf8_put(cp, c->ref_seq_id); + cp += itf8_put(cp, c->ref_seq_start); + cp += itf8_put(cp, c->ref_seq_span); + } + cp += itf8_put(cp, c->num_records); + if (CRAM_MAJOR_VERS(fd->version) == 2) { + cp += itf8_put(cp, c->record_counter); + cp += ltf8_put(cp, c->num_bases); + } else if (CRAM_MAJOR_VERS(fd->version) >= 3) { + cp += ltf8_put(cp, c->record_counter); + cp += ltf8_put(cp, c->num_bases); + } + + cp += itf8_put(cp, c->num_blocks); + cp += itf8_put(cp, c->num_landmarks); + for (i = 0; i < c->num_landmarks; i++) + cp += itf8_put(cp, c->landmark[i]); + + if (CRAM_MAJOR_VERS(fd->version) >= 3) { + c->crc32 = crc32(0L, (uc *)buf, cp-buf); + cp[0] = c->crc32 & 0xff; + cp[1] = (c->crc32 >> 8) & 0xff; + cp[2] = (c->crc32 >> 16) & 0xff; + cp[3] = (c->crc32 >> 24) & 0xff; + cp += 4; + } + + if (cp-buf != hwrite(fd->fp, buf, cp-buf)) { + if (buf != buf_a) + free(buf); + return -1; + } + + if (buf != buf_a) + free(buf); + + return 0; +} + +// common component shared by cram_flush_container{,_mt} +static int cram_flush_container2(cram_fd *fd, cram_container *c) { + int i, j; + + //fprintf(stderr, "Writing container %d, sum %u\n", c->record_counter, sum); + + /* Write the container struct itself */ + if (0 != cram_write_container(fd, c)) + return -1; + + /* And the compression header */ + if (0 != cram_write_block(fd, c->comp_hdr_block)) + return -1; + + /* Followed by the slice blocks */ + for (i = 0; i < c->curr_slice; i++) { + cram_slice *s = c->slices[i]; + + if (0 != cram_write_block(fd, s->hdr_block)) + return -1; + + for (j = 0; j < s->hdr->num_blocks; j++) { + if (0 != cram_write_block(fd, s->block[j])) + return -1; + } + } + + return hflush(fd->fp) == 0 ? 0 : -1; +} + +/* + * Flushes a completely or partially full container to disk, writing + * container structure, header and blocks. This also calls the encoder + * functions. + * + * Returns 0 on success + * -1 on failure + */ +int cram_flush_container(cram_fd *fd, cram_container *c) { + /* Encode the container blocks and generate compression header */ + if (0 != cram_encode_container(fd, c)) + return -1; + + return cram_flush_container2(fd, c); +} + +typedef struct { + cram_fd *fd; + cram_container *c; +} cram_job; + +void *cram_flush_thread(void *arg) { + cram_job *j = (cram_job *)arg; + + /* Encode the container blocks and generate compression header */ + if (0 != cram_encode_container(j->fd, j->c)) { + fprintf(stderr, "cram_encode_container failed\n"); + return NULL; + } + + return arg; +} + +static int cram_flush_result(cram_fd *fd) { + int i, ret = 0; + t_pool_result *r; + + while ((r = t_pool_next_result(fd->rqueue))) { + cram_job *j = (cram_job *)r->data; + cram_container *c; + + if (!j) { + t_pool_delete_result(r, 0); + return -1; + } + + fd = j->fd; + c = j->c; + + if (0 != cram_flush_container2(fd, c)) + return -1; + + /* Free the container */ + for (i = 0; i < c->max_slice; i++) { + cram_free_slice(c->slices[i]); + c->slices[i] = NULL; + } + + c->slice = NULL; + c->curr_slice = 0; + + cram_free_container(c); + + ret |= hflush(fd->fp) == 0 ? 0 : -1; + + t_pool_delete_result(r, 1); + } + + return ret; +} + +int cram_flush_container_mt(cram_fd *fd, cram_container *c) { + cram_job *j; + + if (!fd->pool) + return cram_flush_container(fd, c); + + if (!(j = malloc(sizeof(*j)))) + return -1; + j->fd = fd; + j->c = c; + + t_pool_dispatch(fd->pool, fd->rqueue, cram_flush_thread, j); + + return cram_flush_result(fd); +} + +/* ---------------------------------------------------------------------- + * Compression headers; the first part of the container + */ + +/* + * Creates a new blank container compression header + * + * Returns header ptr on success + * NULL on failure + */ +cram_block_compression_hdr *cram_new_compression_header(void) { + cram_block_compression_hdr *hdr = calloc(1, sizeof(*hdr)); + if (!hdr) + return NULL; + + if (!(hdr->TD_blk = cram_new_block(CORE, 0))) { + free(hdr); + return NULL; + } + + if (!(hdr->TD_hash = kh_init(m_s2i))) { + cram_free_block(hdr->TD_blk); + free(hdr); + return NULL; + } + + if (!(hdr->TD_keys = string_pool_create(8192))) { + kh_destroy(m_s2i, hdr->TD_hash); + cram_free_block(hdr->TD_blk); + free(hdr); + return NULL; + } + + return hdr; +} + +void cram_free_compression_header(cram_block_compression_hdr *hdr) { + int i; + + if (hdr->landmark) + free(hdr->landmark); + + if (hdr->preservation_map) + kh_destroy(map, hdr->preservation_map); + + for (i = 0; i < CRAM_MAP_HASH; i++) { + cram_map *m, *m2; + for (m = hdr->rec_encoding_map[i]; m; m = m2) { + m2 = m->next; + if (m->codec) + m->codec->free(m->codec); + free(m); + } + } + + for (i = 0; i < CRAM_MAP_HASH; i++) { + cram_map *m, *m2; + for (m = hdr->tag_encoding_map[i]; m; m = m2) { + m2 = m->next; + if (m->codec) + m->codec->free(m->codec); + free(m); + } + } + + for (i = 0; i < DS_END; i++) { + if (hdr->codecs[i]) + hdr->codecs[i]->free(hdr->codecs[i]); + } + + if (hdr->TL) + free(hdr->TL); + if (hdr->TD_blk) + cram_free_block(hdr->TD_blk); + if (hdr->TD_hash) + kh_destroy(m_s2i, hdr->TD_hash); + if (hdr->TD_keys) + string_pool_destroy(hdr->TD_keys); + + free(hdr); +} + + +/* ---------------------------------------------------------------------- + * Slices and slice headers + */ + +void cram_free_slice_header(cram_block_slice_hdr *hdr) { + if (!hdr) + return; + + if (hdr->block_content_ids) + free(hdr->block_content_ids); + + free(hdr); + + return; +} + +void cram_free_slice(cram_slice *s) { + if (!s) + return; + + if (s->hdr_block) + cram_free_block(s->hdr_block); + + if (s->block) { + int i; + + if (s->hdr) { + for (i = 0; i < s->hdr->num_blocks; i++) { + cram_free_block(s->block[i]); + } + } + free(s->block); + } + + if (s->block_by_id) + free(s->block_by_id); + + if (s->hdr) + cram_free_slice_header(s->hdr); + + if (s->seqs_blk) + cram_free_block(s->seqs_blk); + + if (s->qual_blk) + cram_free_block(s->qual_blk); + + if (s->name_blk) + cram_free_block(s->name_blk); + + if (s->aux_blk) + cram_free_block(s->aux_blk); + + if (s->aux_OQ_blk) + cram_free_block(s->aux_OQ_blk); + + if (s->aux_BQ_blk) + cram_free_block(s->aux_BQ_blk); + + if (s->aux_FZ_blk) + cram_free_block(s->aux_FZ_blk); + + if (s->aux_oq_blk) + cram_free_block(s->aux_oq_blk); + + if (s->aux_os_blk) + cram_free_block(s->aux_os_blk); + + if (s->aux_oz_blk) + cram_free_block(s->aux_oz_blk); + + if (s->base_blk) + cram_free_block(s->base_blk); + + if (s->soft_blk) + cram_free_block(s->soft_blk); + + if (s->cigar) + free(s->cigar); + + if (s->crecs) + free(s->crecs); + + if (s->features) + free(s->features); + + if (s->TN) + free(s->TN); + + if (s->pair_keys) + string_pool_destroy(s->pair_keys); + + if (s->pair[0]) + kh_destroy(m_s2i, s->pair[0]); + if (s->pair[1]) + kh_destroy(m_s2i, s->pair[1]); + + free(s); +} + +/* + * Creates a new empty slice in memory, for subsequent writing to + * disk. + * + * Returns cram_slice ptr on success + * NULL on failure + */ +cram_slice *cram_new_slice(enum cram_content_type type, int nrecs) { + cram_slice *s = calloc(1, sizeof(*s)); + if (!s) + return NULL; + + if (!(s->hdr = (cram_block_slice_hdr *)calloc(1, sizeof(*s->hdr)))) + goto err; + s->hdr->content_type = type; + + s->hdr_block = NULL; + s->block = NULL; + s->block_by_id = NULL; + s->last_apos = 0; + if (!(s->crecs = malloc(nrecs * sizeof(cram_record)))) goto err; + s->cigar = NULL; + s->cigar_alloc = 0; + s->ncigar = 0; + + if (!(s->seqs_blk = cram_new_block(EXTERNAL, 0))) goto err; + if (!(s->qual_blk = cram_new_block(EXTERNAL, DS_QS))) goto err; + if (!(s->name_blk = cram_new_block(EXTERNAL, DS_RN))) goto err; + if (!(s->aux_blk = cram_new_block(EXTERNAL, DS_aux))) goto err; + if (!(s->base_blk = cram_new_block(EXTERNAL, DS_IN))) goto err; + if (!(s->soft_blk = cram_new_block(EXTERNAL, DS_SC))) goto err; + + s->features = NULL; + s->nfeatures = s->afeatures = 0; + +#ifndef TN_external + s->TN = NULL; + s->nTN = s->aTN = 0; +#endif + + // Volatile keys as we do realloc in dstring + if (!(s->pair_keys = string_pool_create(8192))) goto err; + if (!(s->pair[0] = kh_init(m_s2i))) goto err; + if (!(s->pair[1] = kh_init(m_s2i))) goto err; + +#ifdef BA_external + s->BA_len = 0; +#endif + + return s; + + err: + if (s) + cram_free_slice(s); + + return NULL; +} + +/* + * Loads an entire slice. + * FIXME: In 1.0 the native unit of slices within CRAM is broken + * as slices contain references to objects in other slices. + * To work around this while keeping the slice oriented outer loop + * we read all slices and stitch them together into a fake large + * slice instead. + * + * Returns cram_slice ptr on success + * NULL on failure + */ +cram_slice *cram_read_slice(cram_fd *fd) { + cram_block *b = cram_read_block(fd); + cram_slice *s = calloc(1, sizeof(*s)); + int i, n, max_id, min_id; + + if (!b || !s) + goto err; + + s->hdr_block = b; + switch (b->content_type) { + case MAPPED_SLICE: + case UNMAPPED_SLICE: + if (!(s->hdr = cram_decode_slice_header(fd, b))) + goto err; + break; + + default: + fprintf(stderr, "Unexpected block of type %s\n", + cram_content_type2str(b->content_type)); + goto err; + } + + s->block = calloc(n = s->hdr->num_blocks, sizeof(*s->block)); + if (!s->block) + goto err; + + for (max_id = i = 0, min_id = INT_MAX; i < n; i++) { + if (!(s->block[i] = cram_read_block(fd))) + goto err; + + if (s->block[i]->content_type == EXTERNAL) { + if (max_id < s->block[i]->content_id) + max_id = s->block[i]->content_id; + if (min_id > s->block[i]->content_id) + min_id = s->block[i]->content_id; + } + } + if (min_id >= 0 && max_id < 1024) { + if (!(s->block_by_id = calloc(1024, sizeof(s->block[0])))) + goto err; + + for (i = 0; i < n; i++) { + if (s->block[i]->content_type != EXTERNAL) + continue; + s->block_by_id[s->block[i]->content_id] = s->block[i]; + } + } + + /* Initialise encoding/decoding tables */ + s->cigar = NULL; + s->cigar_alloc = 0; + s->ncigar = 0; + + if (!(s->seqs_blk = cram_new_block(EXTERNAL, 0))) goto err; + if (!(s->qual_blk = cram_new_block(EXTERNAL, DS_QS))) goto err; + if (!(s->name_blk = cram_new_block(EXTERNAL, DS_RN))) goto err; + if (!(s->aux_blk = cram_new_block(EXTERNAL, DS_aux))) goto err; + if (!(s->base_blk = cram_new_block(EXTERNAL, DS_IN))) goto err; + if (!(s->soft_blk = cram_new_block(EXTERNAL, DS_SC))) goto err; + + s->crecs = NULL; + + s->last_apos = s->hdr->ref_seq_start; + + return s; + + err: + if (b) + cram_free_block(b); + if (s) { + s->hdr_block = NULL; + cram_free_slice(s); + } + return NULL; +} + + +/* ---------------------------------------------------------------------- + * CRAM file definition (header) + */ + +/* + * Reads a CRAM file definition structure. + * Returns file_def ptr on success + * NULL on failure + */ +cram_file_def *cram_read_file_def(cram_fd *fd) { + cram_file_def *def = malloc(sizeof(*def)); + if (!def) + return NULL; + + if (26 != hread(fd->fp, &def->magic[0], 26)) { + free(def); + return NULL; + } + + if (memcmp(def->magic, "CRAM", 4) != 0) { + free(def); + return NULL; + } + + if (def->major_version > 3) { + fprintf(stderr, "CRAM version number mismatch\n" + "Expected 1.x, 2.x or 3.x, got %d.%d\n", + def->major_version, def->minor_version); + free(def); + return NULL; + } + + fd->first_container += 26; + fd->last_slice = 0; + + return def; +} + +/* + * Writes a cram_file_def structure to cram_fd. + * Returns 0 on success + * -1 on failure + */ +int cram_write_file_def(cram_fd *fd, cram_file_def *def) { + return (hwrite(fd->fp, &def->magic[0], 26) == 26) ? 0 : -1; +} + +void cram_free_file_def(cram_file_def *def) { + if (def) free(def); +} + +/* ---------------------------------------------------------------------- + * SAM header I/O + */ + + +/* + * Reads the SAM header from the first CRAM data block. + * Also performs minimal parsing to extract read-group + * and sample information. + + * Returns SAM hdr ptr on success + * NULL on failure + */ +SAM_hdr *cram_read_SAM_hdr(cram_fd *fd) { + int32_t header_len; + char *header; + SAM_hdr *hdr; + + /* 1.1 onwards stores the header in the first block of a container */ + if (CRAM_MAJOR_VERS(fd->version) == 1) { + /* Length */ + if (-1 == int32_decode(fd, &header_len)) + return NULL; + + /* Alloc and read */ + if (NULL == (header = malloc(header_len+1))) + return NULL; + + *header = 0; + if (header_len != hread(fd->fp, header, header_len)) + return NULL; + + fd->first_container += 4 + header_len; + } else { + cram_container *c = cram_read_container(fd); + cram_block *b; + int i, len; + + if (!c) + return NULL; + + if (c->num_blocks < 1) { + cram_free_container(c); + return NULL; + } + + if (!(b = cram_read_block(fd))) { + cram_free_container(c); + return NULL; + } + cram_uncompress_block(b); + + len = b->comp_size + 2 + 4*(CRAM_MAJOR_VERS(fd->version) >= 3) + + itf8_size(b->content_id) + + itf8_size(b->uncomp_size) + + itf8_size(b->comp_size); + + /* Extract header from 1st block */ + if (-1 == int32_get(b, &header_len) || + b->uncomp_size - 4 < header_len) { + cram_free_container(c); + cram_free_block(b); + return NULL; + } + if (NULL == (header = malloc(header_len+1))) { + cram_free_container(c); + cram_free_block(b); + return NULL; + } + memcpy(header, BLOCK_END(b), header_len); + header[header_len]='\0'; + cram_free_block(b); + + /* Consume any remaining blocks */ + for (i = 1; i < c->num_blocks; i++) { + if (!(b = cram_read_block(fd))) { + cram_free_container(c); + return NULL; + } + len += b->comp_size + 2 + 4*(CRAM_MAJOR_VERS(fd->version) >= 3) + + itf8_size(b->content_id) + + itf8_size(b->uncomp_size) + + itf8_size(b->comp_size); + cram_free_block(b); + } + + if (c->length && c->length > len) { + // Consume padding + char *pads = malloc(c->length - len); + if (!pads) { + cram_free_container(c); + return NULL; + } + + if (c->length - len != hread(fd->fp, pads, c->length - len)) { + cram_free_container(c); + return NULL; + } + free(pads); + } + + cram_free_container(c); + } + + /* Parse */ + hdr = sam_hdr_parse_(header, header_len); + free(header); + + return hdr; +} + +/* + * Converts 'in' to a full pathname to store in out. + * Out must be at least PATH_MAX bytes long. + */ +static void full_path(char *out, char *in) { + if (*in == '/') { + strncpy(out, in, PATH_MAX); + out[PATH_MAX-1] = 0; + } else { + int len; + + // unable to get dir or out+in is too long + if (!getcwd(out, PATH_MAX) || + (len = strlen(out))+1+strlen(in) >= PATH_MAX) { + strncpy(out, in, PATH_MAX); + out[PATH_MAX-1] = 0; + return; + } + + sprintf(out+len, "/%.*s", PATH_MAX - len, in); + + // FIXME: cope with `pwd`/../../../foo.fa ? + } +} + +/* + * Writes a CRAM SAM header. + * Returns 0 on success + * -1 on failure + */ +int cram_write_SAM_hdr(cram_fd *fd, SAM_hdr *hdr) { + int header_len; + int blank_block = (CRAM_MAJOR_VERS(fd->version) >= 3); + + /* Write CRAM MAGIC if not yet written. */ + if (fd->file_def->major_version == 0) { + fd->file_def->major_version = CRAM_MAJOR_VERS(fd->version); + fd->file_def->minor_version = CRAM_MINOR_VERS(fd->version); + if (0 != cram_write_file_def(fd, fd->file_def)) + return -1; + } + + /* 1.0 requires and UNKNOWN read-group */ + if (CRAM_MAJOR_VERS(fd->version) == 1) { + if (!sam_hdr_find_rg(hdr, "UNKNOWN")) + if (sam_hdr_add(hdr, "RG", + "ID", "UNKNOWN", "SM", "UNKNOWN", NULL)) + return -1; + } + + /* Fix M5 strings */ + if (fd->refs && !fd->no_ref) { + int i; + for (i = 0; i < hdr->nref; i++) { + SAM_hdr_type *ty; + char *ref; + + if (!(ty = sam_hdr_find(hdr, "SQ", "SN", hdr->ref[i].name))) + return -1; + + if (!sam_hdr_find_key(hdr, ty, "M5", NULL)) { + char unsigned buf[16], buf2[33]; + int j, rlen; + MD5_CTX md5; + + if (!fd->refs || + !fd->refs->ref_id || + !fd->refs->ref_id[i]) { + return -1; + } + rlen = fd->refs->ref_id[i]->length; + MD5_Init(&md5); + ref = cram_get_ref(fd, i, 1, rlen); + if (NULL == ref) return -1; + rlen = fd->refs->ref_id[i]->length; /* In case it just loaded */ + MD5_Update(&md5, ref, rlen); + MD5_Final(buf, &md5); + cram_ref_decr(fd->refs, i); + + for (j = 0; j < 16; j++) { + buf2[j*2+0] = "0123456789abcdef"[buf[j]>>4]; + buf2[j*2+1] = "0123456789abcdef"[buf[j]&15]; + } + buf2[32] = 0; + if (sam_hdr_update(hdr, ty, "M5", buf2, NULL)) + return -1; + } + + if (fd->ref_fn) { + char ref_fn[PATH_MAX]; + full_path(ref_fn, fd->ref_fn); + if (sam_hdr_update(hdr, ty, "UR", ref_fn, NULL)) + return -1; + } + } + } + + if (sam_hdr_rebuild(hdr)) + return -1; + + /* Length */ + header_len = sam_hdr_length(hdr); + if (CRAM_MAJOR_VERS(fd->version) == 1) { + if (-1 == int32_encode(fd, header_len)) + return -1; + + /* Text data */ + if (header_len != hwrite(fd->fp, sam_hdr_str(hdr), header_len)) + return -1; + } else { + /* Create block(s) inside a container */ + cram_block *b = cram_new_block(FILE_HEADER, 0); + cram_container *c = cram_new_container(0, 0); + int padded_length; + char *pads; + int is_cram_3 = (CRAM_MAJOR_VERS(fd->version) >= 3); + + if (!b || !c) { + if (b) cram_free_block(b); + if (c) cram_free_container(c); + return -1; + } + + int32_put(b, header_len); + BLOCK_APPEND(b, sam_hdr_str(hdr), header_len); + BLOCK_UPLEN(b); + + // Compress header block if V3.0 and above + if (CRAM_MAJOR_VERS(fd->version) >= 3 && fd->level > 0) { + int method = 1<<GZIP; + if (fd->use_bz2) + method |= 1<<BZIP2; + if (fd->use_lzma) + method |= 1<<LZMA; + cram_compress_block(fd, b, NULL, method, fd->level); + } + + if (blank_block) { + c->length = b->comp_size + 2 + 4*is_cram_3 + + itf8_size(b->content_id) + + itf8_size(b->uncomp_size) + + itf8_size(b->comp_size); + + c->num_blocks = 2; + c->num_landmarks = 2; + if (!(c->landmark = malloc(2*sizeof(*c->landmark)))) { + cram_free_block(b); + cram_free_container(c); + return -1; + } + c->landmark[0] = 0; + c->landmark[1] = c->length; + + // Plus extra storage for uncompressed secondary blank block + padded_length = MIN(c->length*.5, 10000); + c->length += padded_length + 2 + 4*is_cram_3 + + itf8_size(b->content_id) + + itf8_size(padded_length)*2; + } else { + // Pad the block instead. + c->num_blocks = 1; + c->num_landmarks = 1; + if (!(c->landmark = malloc(sizeof(*c->landmark)))) + return -1; + c->landmark[0] = 0; + + padded_length = MAX(c->length*1.5, 10000) - c->length; + + c->length = b->comp_size + padded_length + + 2 + 4*is_cram_3 + + itf8_size(b->content_id) + + itf8_size(b->uncomp_size) + + itf8_size(b->comp_size); + + if (NULL == (pads = calloc(1, padded_length))) { + cram_free_block(b); + cram_free_container(c); + return -1; + } + BLOCK_APPEND(b, pads, padded_length); + BLOCK_UPLEN(b); + free(pads); + } + + if (-1 == cram_write_container(fd, c)) { + cram_free_block(b); + cram_free_container(c); + return -1; + } + + if (-1 == cram_write_block(fd, b)) { + cram_free_block(b); + cram_free_container(c); + return -1; + } + + if (blank_block) { + BLOCK_RESIZE(b, padded_length); + memset(BLOCK_DATA(b), 0, padded_length); + BLOCK_SIZE(b) = padded_length; + BLOCK_UPLEN(b); + b->method = RAW; + if (-1 == cram_write_block(fd, b)) { + cram_free_block(b); + cram_free_container(c); + return -1; + } + } + + cram_free_block(b); + cram_free_container(c); + } + + if (-1 == refs_from_header(fd->refs, fd, fd->header)) + return -1; + if (-1 == refs2id(fd->refs, fd->header)) + return -1; + + if (0 != hflush(fd->fp)) + return -1; + + RP("=== Finishing saving header ===\n"); + + return 0; +} + +/* ---------------------------------------------------------------------- + * The top-level cram opening, closing and option handling + */ + +/* + * Initialises the lookup tables. These could be global statics, but they're + * clumsy to setup in a multi-threaded environment unless we generate + * verbatim code and include that. + */ +static void cram_init_tables(cram_fd *fd) { + int i; + + memset(fd->L1, 4, 256); + fd->L1['A'] = 0; fd->L1['a'] = 0; + fd->L1['C'] = 1; fd->L1['c'] = 1; + fd->L1['G'] = 2; fd->L1['g'] = 2; + fd->L1['T'] = 3; fd->L1['t'] = 3; + + memset(fd->L2, 5, 256); + fd->L2['A'] = 0; fd->L2['a'] = 0; + fd->L2['C'] = 1; fd->L2['c'] = 1; + fd->L2['G'] = 2; fd->L2['g'] = 2; + fd->L2['T'] = 3; fd->L2['t'] = 3; + fd->L2['N'] = 4; fd->L2['n'] = 4; + + if (CRAM_MAJOR_VERS(fd->version) == 1) { + for (i = 0; i < 0x200; i++) { + int f = 0; + + if (i & CRAM_FPAIRED) f |= BAM_FPAIRED; + if (i & CRAM_FPROPER_PAIR) f |= BAM_FPROPER_PAIR; + if (i & CRAM_FUNMAP) f |= BAM_FUNMAP; + if (i & CRAM_FREVERSE) f |= BAM_FREVERSE; + if (i & CRAM_FREAD1) f |= BAM_FREAD1; + if (i & CRAM_FREAD2) f |= BAM_FREAD2; + if (i & CRAM_FSECONDARY) f |= BAM_FSECONDARY; + if (i & CRAM_FQCFAIL) f |= BAM_FQCFAIL; + if (i & CRAM_FDUP) f |= BAM_FDUP; + + fd->bam_flag_swap[i] = f; + } + + for (i = 0; i < 0x1000; i++) { + int g = 0; + + if (i & BAM_FPAIRED) g |= CRAM_FPAIRED; + if (i & BAM_FPROPER_PAIR) g |= CRAM_FPROPER_PAIR; + if (i & BAM_FUNMAP) g |= CRAM_FUNMAP; + if (i & BAM_FREVERSE) g |= CRAM_FREVERSE; + if (i & BAM_FREAD1) g |= CRAM_FREAD1; + if (i & BAM_FREAD2) g |= CRAM_FREAD2; + if (i & BAM_FSECONDARY) g |= CRAM_FSECONDARY; + if (i & BAM_FQCFAIL) g |= CRAM_FQCFAIL; + if (i & BAM_FDUP) g |= CRAM_FDUP; + + fd->cram_flag_swap[i] = g; + } + } else { + /* NOP */ + for (i = 0; i < 0x1000; i++) + fd->bam_flag_swap[i] = i; + for (i = 0; i < 0x1000; i++) + fd->cram_flag_swap[i] = i; + } + + memset(fd->cram_sub_matrix, 4, 32*32); + for (i = 0; i < 32; i++) { + fd->cram_sub_matrix[i]['A'&0x1f]=0; + fd->cram_sub_matrix[i]['C'&0x1f]=1; + fd->cram_sub_matrix[i]['G'&0x1f]=2; + fd->cram_sub_matrix[i]['T'&0x1f]=3; + fd->cram_sub_matrix[i]['N'&0x1f]=4; + } + for (i = 0; i < 20; i+=4) { + int j; + for (j = 0; j < 20; j++) { + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][j]=3; + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][j]=3; + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][j]=3; + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][j]=3; + } + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][CRAM_SUBST_MATRIX[i+0]&0x1f]=0; + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][CRAM_SUBST_MATRIX[i+1]&0x1f]=1; + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][CRAM_SUBST_MATRIX[i+2]&0x1f]=2; + fd->cram_sub_matrix["ACGTN"[i>>2]&0x1f][CRAM_SUBST_MATRIX[i+3]&0x1f]=3; + } +} + +// Default version numbers for CRAM +static int major_version = 2; +static int minor_version = 1; + +/* + * Opens a CRAM file for read (mode "rb") or write ("wb"). + * The filename may be "-" to indicate stdin or stdout. + * + * Returns file handle on success + * NULL on failure. + */ +cram_fd *cram_open(const char *filename, const char *mode) { + hFILE *fp; + cram_fd *fd; + char fmode[3]= { mode[0], '\0', '\0' }; + + if (strlen(mode) > 1 && (mode[1] == 'b' || mode[1] == 'c')) { + fmode[1] = 'b'; + } + + fp = hopen(filename, fmode); + if (!fp) + return NULL; + + fd = cram_dopen(fp, filename, mode); + if (!fd) + hclose_abruptly(fp); + + return fd; +} + +/* Opens an existing stream for reading or writing. + * + * Returns file handle on success; + * NULL on failure. + */ +cram_fd *cram_dopen(hFILE *fp, const char *filename, const char *mode) { + int i; + char *cp; + cram_fd *fd = calloc(1, sizeof(*fd)); + if (!fd) + return NULL; + + fd->level = 5; + for (i = 0; mode[i]; i++) { + if (mode[i] >= '0' && mode[i] <= '9') { + fd->level = mode[i] - '0'; + break; + } + } + + fd->fp = fp; + fd->mode = *mode; + fd->first_container = 0; + + if (fd->mode == 'r') { + /* Reader */ + + if (!(fd->file_def = cram_read_file_def(fd))) + goto err; + + fd->version = fd->file_def->major_version * 256 + + fd->file_def->minor_version; + + if (!(fd->header = cram_read_SAM_hdr(fd))) + goto err; + + } else { + /* Writer */ + cram_file_def *def = calloc(1, sizeof(*def)); + if (!def) + return NULL; + + fd->file_def = def; + + def->magic[0] = 'C'; + def->magic[1] = 'R'; + def->magic[2] = 'A'; + def->magic[3] = 'M'; + def->major_version = 0; // Indicator to write file def later. + def->minor_version = 0; + memset(def->file_id, 0, 20); + strncpy(def->file_id, filename, 20); + + fd->version = major_version * 256 + minor_version; + + /* SAM header written later along with this file_def */ + } + + cram_init_tables(fd); + + fd->prefix = strdup((cp = strrchr(filename, '/')) ? cp+1 : filename); + if (!fd->prefix) + goto err; + fd->first_base = fd->last_base = -1; + fd->record_counter = 0; + + fd->ctr = NULL; + fd->refs = refs_create(); + if (!fd->refs) + goto err; + fd->ref_id = -2; + fd->ref = NULL; + + fd->decode_md = 0; + fd->verbose = 0; + fd->seqs_per_slice = SEQS_PER_SLICE; + fd->slices_per_container = SLICE_PER_CNT; + fd->embed_ref = 0; + fd->no_ref = 0; + fd->ignore_md5 = 0; + fd->use_bz2 = 0; + fd->use_rans = (CRAM_MAJOR_VERS(fd->version) >= 3); + fd->use_lzma = 0; + fd->multi_seq = -1; + fd->unsorted = 0; + fd->shared_ref = 0; + + fd->index = NULL; + fd->own_pool = 0; + fd->pool = NULL; + fd->rqueue = NULL; + fd->job_pending = NULL; + fd->ooc = 0; + fd->required_fields = INT_MAX; + + for (i = 0; i < DS_END; i++) + fd->m[i] = cram_new_metrics(); + + fd->range.refid = -2; // no ref. + fd->eof = 1; // See samtools issue #150 + fd->ref_fn = NULL; + + fd->bl = NULL; + + /* Initialise dummy refs from the @SQ headers */ + if (-1 == refs_from_header(fd->refs, fd, fd->header)) + goto err; + + return fd; + + err: + if (fd) + free(fd); + + return NULL; +} + +/* + * Seek within a CRAM file. + * + * Returns 0 on success + * -1 on failure + */ +int cram_seek(cram_fd *fd, off_t offset, int whence) { + char buf[65536]; + + fd->ooc = 0; + + if (hseek(fd->fp, offset, whence) >= 0) + return 0; + + if (!(whence == SEEK_CUR && offset >= 0)) + return -1; + + /* Couldn't fseek, but we're in SEEK_CUR mode so read instead */ + while (offset > 0) { + int len = MIN(65536, offset); + if (len != hread(fd->fp, buf, len)) + return -1; + offset -= len; + } + + return 0; +} + +/* + * Flushes a CRAM file. + * Useful for when writing to stdout without wishing to close the stream. + * + * Returns 0 on success + * -1 on failure + */ +int cram_flush(cram_fd *fd) { + if (!fd) + return -1; + + if (fd->mode == 'w' && fd->ctr) { + if(fd->ctr->slice) + fd->ctr->curr_slice++; + if (-1 == cram_flush_container_mt(fd, fd->ctr)) + return -1; + } + + return 0; +} + +/* + * Closes a CRAM file. + * Returns 0 on success + * -1 on failure + */ +int cram_close(cram_fd *fd) { + spare_bams *bl, *next; + int i; + + if (!fd) + return -1; + + if (fd->mode == 'w' && fd->ctr) { + if(fd->ctr->slice) + fd->ctr->curr_slice++; + if (-1 == cram_flush_container_mt(fd, fd->ctr)) + return -1; + } + + if (fd->pool) { + t_pool_flush(fd->pool); + + if (0 != cram_flush_result(fd)) + return -1; + + pthread_mutex_destroy(&fd->metrics_lock); + pthread_mutex_destroy(&fd->ref_lock); + pthread_mutex_destroy(&fd->bam_list_lock); + + fd->ctr = NULL; // prevent double freeing + + //fprintf(stderr, "CRAM: destroy queue %p\n", fd->rqueue); + + t_results_queue_destroy(fd->rqueue); + } + + if (fd->mode == 'w') { + /* Write EOF block */ + if (CRAM_MAJOR_VERS(fd->version) == 3) { + if (38 != hwrite(fd->fp, + "\x0f\x00\x00\x00\xff\xff\xff\xff" // Cont HDR + "\x0f\xe0\x45\x4f\x46\x00\x00\x00" // Cont HDR + "\x00\x01\x00" // Cont HDR + "\x05\xbd\xd9\x4f" // CRC32 + "\x00\x01\x00\x06\x06" // Comp.HDR blk + "\x01\x00\x01\x00\x01\x00" // Comp.HDR blk + "\xee\x63\x01\x4b", // CRC32 + 38)) + return -1; + } else { + if (30 != hwrite(fd->fp, + "\x0b\x00\x00\x00\xff\xff\xff\xff" + "\x0f\xe0\x45\x4f\x46\x00\x00\x00" + "\x00\x01\x00\x00\x01\x00\x06\x06" + "\x01\x00\x01\x00\x01\x00", 30)) + return -1; + } + } + + for (bl = fd->bl; bl; bl = next) { + int i, max_rec = fd->seqs_per_slice * fd->slices_per_container; + + next = bl->next; + for (i = 0; i < max_rec; i++) { + if (bl->bams[i]) + bam_free(bl->bams[i]); + } + free(bl->bams); + free(bl); + } + + if (hclose(fd->fp) != 0) + return -1; + + if (fd->file_def) + cram_free_file_def(fd->file_def); + + if (fd->header) + sam_hdr_free(fd->header); + + free(fd->prefix); + + if (fd->ctr) + cram_free_container(fd->ctr); + + if (fd->refs) + refs_free(fd->refs); + if (fd->ref_free) + free(fd->ref_free); + + for (i = 0; i < DS_END; i++) + if (fd->m[i]) + free(fd->m[i]); + + if (fd->index) + cram_index_free(fd); + + if (fd->own_pool && fd->pool) + t_pool_destroy(fd->pool, 0); + + free(fd); + return 0; +} + +/* + * Returns 1 if we hit an EOF while reading. + */ +int cram_eof(cram_fd *fd) { + return fd->eof; +} + + +/* + * Sets options on the cram_fd. See CRAM_OPT_* definitions in cram_structs.h. + * Use this immediately after opening. + * + * Returns 0 on success + * -1 on failure + */ +int cram_set_option(cram_fd *fd, enum cram_option opt, ...) { + int r; + va_list args; + + va_start(args, opt); + r = cram_set_voption(fd, opt, args); + va_end(args); + + return r; +} + +/* + * Sets options on the cram_fd. See CRAM_OPT_* definitions in cram_structs.h. + * Use this immediately after opening. + * + * Returns 0 on success + * -1 on failure + */ +int cram_set_voption(cram_fd *fd, enum cram_option opt, va_list args) { + refs_t *refs; + + if (!fd) + return -1; + + switch (opt) { + case CRAM_OPT_DECODE_MD: + fd->decode_md = va_arg(args, int); + break; + + case CRAM_OPT_PREFIX: + if (fd->prefix) + free(fd->prefix); + if (!(fd->prefix = strdup(va_arg(args, char *)))) + return -1; + break; + + case CRAM_OPT_VERBOSITY: + fd->verbose = va_arg(args, int); + break; + + case CRAM_OPT_SEQS_PER_SLICE: + fd->seqs_per_slice = va_arg(args, int); + break; + + case CRAM_OPT_SLICES_PER_CONTAINER: + fd->slices_per_container = va_arg(args, int); + break; + + case CRAM_OPT_EMBED_REF: + fd->embed_ref = va_arg(args, int); + break; + + case CRAM_OPT_NO_REF: + fd->no_ref = va_arg(args, int); + break; + + case CRAM_OPT_IGNORE_MD5: + fd->ignore_md5 = va_arg(args, int); + break; + + case CRAM_OPT_USE_BZIP2: + fd->use_bz2 = va_arg(args, int); + break; + + case CRAM_OPT_USE_RANS: + fd->use_rans = va_arg(args, int); + break; + + case CRAM_OPT_USE_LZMA: + fd->use_lzma = va_arg(args, int); + break; + + case CRAM_OPT_SHARED_REF: + fd->shared_ref = 1; + refs = va_arg(args, refs_t *); + if (refs != fd->refs) { + if (fd->refs) + refs_free(fd->refs); + fd->refs = refs; + fd->refs->count++; + } + break; + + case CRAM_OPT_RANGE: + fd->range = *va_arg(args, cram_range *); + return cram_seek_to_refpos(fd, &fd->range); + + case CRAM_OPT_REFERENCE: + return cram_load_reference(fd, va_arg(args, char *)); + + case CRAM_OPT_VERSION: { + int major, minor; + char *s = va_arg(args, char *); + if (2 != sscanf(s, "%d.%d", &major, &minor)) { + fprintf(stderr, "Malformed version string %s\n", s); + return -1; + } + if (!((major == 1 && minor == 0) || + (major == 2 && (minor == 0 || minor == 1)) || + (major == 3 && minor == 0))) { + fprintf(stderr, "Unknown version string; " + "use 1.0, 2.0, 2.1 or 3.0\n"); + return -1; + } + fd->version = major*256 + minor; + + if (CRAM_MAJOR_VERS(fd->version) >= 3) + fd->use_rans = 1; + break; + } + + case CRAM_OPT_MULTI_SEQ_PER_SLICE: + fd->multi_seq = va_arg(args, int); + break; + + case CRAM_OPT_NTHREADS: { + int nthreads = va_arg(args, int); + if (nthreads > 1) { + if (!(fd->pool = t_pool_init(nthreads*2, nthreads))) + return -1; + + fd->rqueue = t_results_queue_init(); + pthread_mutex_init(&fd->metrics_lock, NULL); + pthread_mutex_init(&fd->ref_lock, NULL); + pthread_mutex_init(&fd->bam_list_lock, NULL); + fd->shared_ref = 1; + fd->own_pool = 1; + } + break; + } + + case CRAM_OPT_THREAD_POOL: + fd->pool = va_arg(args, t_pool *); + if (fd->pool) { + fd->rqueue = t_results_queue_init(); + pthread_mutex_init(&fd->metrics_lock, NULL); + pthread_mutex_init(&fd->ref_lock, NULL); + pthread_mutex_init(&fd->bam_list_lock, NULL); + } + fd->shared_ref = 1; // Needed to avoid clobbering ref between threads + fd->own_pool = 0; + + //fd->qsize = 1; + //fd->decoded = calloc(fd->qsize, sizeof(cram_container *)); + //t_pool_dispatch(fd->pool, cram_decoder_thread, fd); + break; + + case CRAM_OPT_REQUIRED_FIELDS: + fd->required_fields = va_arg(args, int); + break; + + default: + fprintf(stderr, "Unknown CRAM option code %d\n", opt); + return -1; + } + + return 0; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_io.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,596 @@ +/* +Copyright (c) 2012-2014 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/*! \file + * Include cram.h instead. + * + * This is an internal part of the CRAM system and is automatically included + * when you #include cram.h. + * + * Implements the low level CRAM I/O primitives. + * This includes basic data types such as byte, int, ITF-8, + * maps, bitwise I/O, etc. + */ + +#ifndef _CRAM_IO_H_ +#define _CRAM_IO_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +#define ITF8_MACROS + +#include <stdint.h> +#include <cram/misc.h> + +/**@{ ---------------------------------------------------------------------- + * ITF8 encoding and decoding. + * + * Also see the itf8_get and itf8_put macros. + */ + +/*! INTERNAL: Converts two characters into an integer for use in switch{} */ +#define CRAM_KEY(a,b) (((a)<<8)|((b))) + +/*! Reads an integer in ITF-8 encoding from 'fd' and stores it in + * *val. + * + * @return + * Returns the number of bytes read on success; + * -1 on failure + */ +int itf8_decode(cram_fd *fd, int32_t *val); + +#ifndef ITF8_MACROS +/*! Reads an integer in ITF-8 encoding from 'cp' and stores it in + * *val. + * + * @return + * Returns the number of bytes read on success; + * -1 on failure + */ +int itf8_get(char *cp, int32_t *val_p); + +/*! Stores a value to memory in ITF-8 format. + * + * @return + * Returns the number of bytes required to store the number. + * This is a maximum of 5 bytes. + */ +int itf8_put(char *cp, int32_t val); + +#else + +/* + * Macro implementations of the above + */ +#define itf8_get(c,v) (((uc)(c)[0]<0x80)?(*(v)=(uc)(c)[0],1):(((uc)(c)[0]<0xc0)?(*(v)=(((uc)(c)[0]<<8)|(uc)(c)[1])&0x3fff,2):(((uc)(c)[0]<0xe0)?(*(v)=(((uc)(c)[0]<<16)|((uc)(c)[1]<<8)|(uc)(c)[2])&0x1fffff,3):(((uc)(c)[0]<0xf0)?(*(v)=(((uc)(c)[0]<<24)|((uc)(c)[1]<<16)|((uc)(c)[2]<<8)|(uc)(c)[3])&0x0fffffff,4):(*(v)=(((uc)(c)[0]&0x0f)<<28)|((uc)(c)[1]<<20)|((uc)(c)[2]<<12)|((uc)(c)[3]<<4)|((uc)(c)[4]&0x0f),5))))) + +#define itf8_put(c,v) ((!((v)&~0x7f))?((c)[0]=(v),1):(!((v)&~0x3fff))?((c)[0]=((v)>>8)|0x80,(c)[1]=(v)&0xff,2):(!((v)&~0x1fffff))?((c)[0]=((v)>>16)|0xc0,(c)[1]=((v)>>8)&0xff,(c)[2]=(v)&0xff,3):(!((v)&~0xfffffff))?((c)[0]=((v)>>24)|0xe0,(c)[1]=((v)>>16)&0xff,(c)[2]=((v)>>8)&0xff,(c)[3]=(v)&0xff,4):((c)[0]=0xf0|(((v)>>28)&0xff),(c)[1]=((v)>>20)&0xff,(c)[2]=((v)>>12)&0xff,(c)[3]=((v)>>4)&0xff,(c)[4]=(v)&0xf,5)) + +#define itf8_size(v) ((!((v)&~0x7f))?1:(!((v)&~0x3fff))?2:(!((v)&~0x1fffff))?3:(!((v)&~0xfffffff))?4:5) + +#endif + +int ltf8_get(char *cp, int64_t *val_p); +int ltf8_put(char *cp, int64_t val); + +/*! Pushes a value in ITF8 format onto the end of a block. + * + * This shouldn't be used for high-volume data as it is not the fastest + * method. + * + * @return + * Returns the number of bytes written + */ +int itf8_put_blk(cram_block *blk, int val); + +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * CRAM blocks - the dynamically growable data block. We have code to + * create, update, (un)compress and read/write. + * + * These are derived from the deflate_interlaced.c blocks, but with the + * CRAM extension of content types and IDs. + */ + +/*! Allocates a new cram_block structure with a specified content_type and + * id. + * + * @return + * Returns block pointer on success; + * NULL on failure + */ +cram_block *cram_new_block(enum cram_content_type content_type, + int content_id); + +/*! Reads a block from a cram file. + * + * @return + * Returns cram_block pointer on success; + * NULL on failure + */ +cram_block *cram_read_block(cram_fd *fd); + +/*! Writes a CRAM block. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_write_block(cram_fd *fd, cram_block *b); + +/*! Frees a CRAM block, deallocating internal data too. + */ +void cram_free_block(cram_block *b); + +/*! Uncompress a memory block using Zlib. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +char *zlib_mem_inflate(char *cdata, size_t csize, size_t *size); + +/*! Uncompresses a CRAM block, if compressed. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_uncompress_block(cram_block *b); + +/*! Compresses a block. + * + * Compresses a block using one of two different zlib strategies. If we only + * want one choice set strat2 to be -1. + * + * The logic here is that sometimes Z_RLE does a better job than Z_FILTERED + * or Z_DEFAULT_STRATEGY on quality data. If so, we'd rather use it as it is + * significantly faster. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_compress_block(cram_fd *fd, cram_block *b, cram_metrics *metrics, + int method, int level); + +cram_metrics *cram_new_metrics(void); +char *cram_block_method2str(enum cram_block_method m); +char *cram_content_type2str(enum cram_content_type t); + +/* --- Accessor macros for manipulating blocks on a byte by byte basis --- */ + +/* Block size and data pointer. */ +#define BLOCK_SIZE(b) ((b)->byte) +#define BLOCK_DATA(b) ((b)->data) + +/* Returns the address one past the end of the block */ +#define BLOCK_END(b) (&(b)->data[(b)->byte]) + +/* Request block to be at least 'l' bytes long */ +#define BLOCK_RESIZE(b,l) \ + do { \ + while((b)->alloc <= (l)) { \ + (b)->alloc = (b)->alloc ? (b)->alloc*1.5 : 1024; \ + (b)->data = realloc((b)->data, (b)->alloc); \ + } \ + } while(0) + +/* Ensure the block can hold at least another 'l' bytes */ +#define BLOCK_GROW(b,l) BLOCK_RESIZE((b), BLOCK_SIZE((b)) + (l)) + +/* Append string 's' of length 'l' */ +#define BLOCK_APPEND(b,s,l) \ + do { \ + BLOCK_GROW((b),(l)); \ + memcpy(BLOCK_END((b)), (s), (l)); \ + BLOCK_SIZE((b)) += (l); \ + } while (0) + +/* Append as single character 'c' */ +#define BLOCK_APPEND_CHAR(b,c) \ + do { \ + BLOCK_GROW((b),1); \ + (b)->data[(b)->byte++] = (c); \ + } while (0) + +/* Append a single unsigned integer */ +#define BLOCK_APPEND_UINT(b,i) \ + do { \ + unsigned char *cp; \ + BLOCK_GROW((b),11); \ + cp = &(b)->data[(b)->byte]; \ + (b)->byte += append_uint32(cp, (i)) - cp; \ + } while (0) + +static inline unsigned char *append_uint32(unsigned char *cp, uint32_t i) { + uint32_t j; + + if (i == 0) { + *cp++ = '0'; + return cp; + } + + if (i < 100) goto b1; + if (i < 10000) goto b3; + if (i < 1000000) goto b5; + if (i < 100000000) goto b7; + + if ((j = i / 1000000000)) {*cp++ = j + '0'; i -= j*1000000000; goto x8;} + if ((j = i / 100000000)) {*cp++ = j + '0'; i -= j*100000000; goto x7;} + b7:if ((j = i / 10000000)) {*cp++ = j + '0'; i -= j*10000000; goto x6;} + if ((j = i / 1000000)) {*cp++ = j + '0', i -= j*1000000; goto x5;} + b5:if ((j = i / 100000)) {*cp++ = j + '0', i -= j*100000; goto x4;} + if ((j = i / 10000)) {*cp++ = j + '0', i -= j*10000; goto x3;} + b3:if ((j = i / 1000)) {*cp++ = j + '0', i -= j*1000; goto x2;} + if ((j = i / 100)) {*cp++ = j + '0', i -= j*100; goto x1;} + b1:if ((j = i / 10)) {*cp++ = j + '0', i -= j*10; goto x0;} + if (i) *cp++ = i + '0'; + return cp; + + x8: *cp++ = i / 100000000 + '0', i %= 100000000; + x7: *cp++ = i / 10000000 + '0', i %= 10000000; + x6: *cp++ = i / 1000000 + '0', i %= 1000000; + x5: *cp++ = i / 100000 + '0', i %= 100000; + x4: *cp++ = i / 10000 + '0', i %= 10000; + x3: *cp++ = i / 1000 + '0', i %= 1000; + x2: *cp++ = i / 100 + '0', i %= 100; + x1: *cp++ = i / 10 + '0', i %= 10; + x0: *cp++ = i + '0'; + + return cp; +} + +static inline unsigned char *append_sub32(unsigned char *cp, uint32_t i) { + *cp++ = i / 100000000 + '0', i %= 100000000; + *cp++ = i / 10000000 + '0', i %= 10000000; + *cp++ = i / 1000000 + '0', i %= 1000000; + *cp++ = i / 100000 + '0', i %= 100000; + *cp++ = i / 10000 + '0', i %= 10000; + *cp++ = i / 1000 + '0', i %= 1000; + *cp++ = i / 100 + '0', i %= 100; + *cp++ = i / 10 + '0', i %= 10; + *cp++ = i + '0'; + + return cp; +} + +static inline unsigned char *append_uint64(unsigned char *cp, uint64_t i) { + uint64_t j; + + if (i <= 0xffffffff) + return append_uint32(cp, i); + + if ((j = i/1000000000) > 1000000000) { + cp = append_uint32(cp, j/1000000000); + j %= 1000000000; + cp = append_sub32(cp, j); + } else { + cp = append_uint32(cp, i / 1000000000); + } + cp = append_sub32(cp, i % 1000000000); + + return cp; +} + +#define BLOCK_UPLEN(b) \ + (b)->comp_size = (b)->uncomp_size = BLOCK_SIZE((b)) + +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * Reference sequence handling + */ + +/*! Loads a reference set from fn and stores in the cram_fd. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_load_reference(cram_fd *fd, char *fn); + +/*! Generates a lookup table in refs based on the SQ headers in SAM_hdr. + * + * Indexes references by the order they appear in a BAM file. This may not + * necessarily be the same order they appear in the fasta reference file. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int refs2id(refs_t *r, SAM_hdr *bfd); + +void refs_free(refs_t *r); + +/*! Returns a portion of a reference sequence from start to end inclusive. + * + * The returned pointer is owned by the cram_file fd and should not be freed + * by the caller. It is valid only until the next cram_get_ref is called + * with the same fd parameter (so is thread-safe if given multiple files). + * + * To return the entire reference sequence, specify start as 1 and end + * as 0. + * + * @return + * Returns reference on success; + * NULL on failure + */ +char *cram_get_ref(cram_fd *fd, int id, int start, int end); +void cram_ref_incr(refs_t *r, int id); +void cram_ref_decr(refs_t *r, int id); +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * Containers + */ + +/*! Creates a new container, specifying the maximum number of slices + * and records permitted. + * + * @return + * Returns cram_container ptr on success; + * NULL on failure + */ +cram_container *cram_new_container(int nrec, int nslice); +void cram_free_container(cram_container *c); + +/*! Reads a container header. + * + * @return + * Returns cram_container on success; + * NULL on failure or no container left (fd->err == 0). + */ +cram_container *cram_read_container(cram_fd *fd); + +/*! Writes a container structure. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_write_container(cram_fd *fd, cram_container *h); + +/*! Flushes a container to disk. + * + * Flushes a completely or partially full container to disk, writing + * container structure, header and blocks. This also calls the encoder + * functions. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_flush_container(cram_fd *fd, cram_container *c); +int cram_flush_container_mt(cram_fd *fd, cram_container *c); + + +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * Compression headers; the first part of the container + */ + +/*! Creates a new blank container compression header + * + * @return + * Returns header ptr on success; + * NULL on failure + */ +cram_block_compression_hdr *cram_new_compression_header(void); + +/*! Frees a cram_block_compression_hdr */ +void cram_free_compression_header(cram_block_compression_hdr *hdr); + + +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * Slices and slice headers + */ + +/*! Frees a slice header */ +void cram_free_slice_header(cram_block_slice_hdr *hdr); + +/*! Frees a slice */ +void cram_free_slice(cram_slice *s); + +/*! Creates a new empty slice in memory, for subsequent writing to + * disk. + * + * @return + * Returns cram_slice ptr on success; + * NULL on failure + */ +cram_slice *cram_new_slice(enum cram_content_type type, int nrecs); + +/*! Loads an entire slice. + * + * FIXME: In 1.0 the native unit of slices within CRAM is broken + * as slices contain references to objects in other slices. + * To work around this while keeping the slice oriented outer loop + * we read all slices and stitch them together into a fake large + * slice instead. + * + * @return + * Returns cram_slice ptr on success; + * NULL on failure + */ +cram_slice *cram_read_slice(cram_fd *fd); + + + +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * CRAM file definition (header) + */ + +/*! Reads a CRAM file definition structure. + * + * @return + * Returns file_def ptr on success; + * NULL on failure + */ +cram_file_def *cram_read_file_def(cram_fd *fd); + +/*! Writes a cram_file_def structure to cram_fd. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_write_file_def(cram_fd *fd, cram_file_def *def); + +/*! Frees a cram_file_def structure. */ +void cram_free_file_def(cram_file_def *def); + + +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * SAM header I/O + */ + +/*! Reads the SAM header from the first CRAM data block. + * + * Also performs minimal parsing to extract read-group + * and sample information. + * + * @return + * Returns SAM hdr ptr on success; + * NULL on failure + */ +SAM_hdr *cram_read_SAM_hdr(cram_fd *fd); + +/*! Writes a CRAM SAM header. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_write_SAM_hdr(cram_fd *fd, SAM_hdr *hdr); + + +/**@}*/ +/**@{ ---------------------------------------------------------------------- + * The top-level cram opening, closing and option handling + */ + +/*! Opens a CRAM file for read (mode "rb") or write ("wb"). + * + * The filename may be "-" to indicate stdin or stdout. + * + * @return + * Returns file handle on success; + * NULL on failure. + */ +cram_fd *cram_open(const char *filename, const char *mode); + +/*! Opens an existing stream for reading or writing. + * + * @return + * Returns file handle on success; + * NULL on failure. + */ +cram_fd *cram_dopen(struct hFILE *fp, const char *filename, const char *mode); + +/*! Closes a CRAM file. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_close(cram_fd *fd); + +/* + * Seek within a CRAM file. + * + * Returns 0 on success + * -1 on failure + */ +int cram_seek(cram_fd *fd, off_t offset, int whence); + +/* + * Flushes a CRAM file. + * Useful for when writing to stdout without wishing to close the stream. + * + * Returns 0 on success + * -1 on failure + */ +int cram_flush(cram_fd *fd); + +/*! Checks for end of file on a cram_fd stream. + * + * @return + * Returns 0 if not at end of file + * 1 if we hit an expected EOF (end of range or EOF block) + * 2 for other EOF (end of stream without EOF block) + */ +int cram_eof(cram_fd *fd); + +/*! Sets options on the cram_fd. + * + * See CRAM_OPT_* definitions in cram_structs.h. + * Use this immediately after opening. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_set_option(cram_fd *fd, enum cram_option opt, ...); + +/*! Sets options on the cram_fd. + * + * See CRAM_OPT_* definitions in cram_structs.h. + * Use this immediately after opening. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_set_voption(cram_fd *fd, enum cram_option opt, va_list args); + +/*! + * Attaches a header to a cram_fd. + * + * This should be used when creating a new cram_fd for writing where + * we have an SAM_hdr already constructed (eg from a file we've read + * in). + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int cram_set_header(cram_fd *fd, SAM_hdr *hdr); + + +#ifdef __cplusplus +} +#endif + +#endif /* _CRAM_IO_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_samtools.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,147 @@ +/* +Copyright (c) 2010-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#include <assert.h> +#include <string.h> +#include <stdlib.h> + +#include "cram/cram.h" +#include "htslib/sam.h" + +/*--------------------------------------------------------------------------- + * Samtools compatibility portion + */ +int bam_construct_seq(bam_seq_t **bp, size_t extra_len, + const char *qname, size_t qname_len, + int flag, + int rname, // Ref ID + int pos, + int end, // aligned start/end coords + int mapq, + uint32_t ncigar, const uint32_t *cigar, + int mrnm, // Mate Ref ID + int mpos, + int isize, + int len, + const char *seq, + const char *qual) { + static const char L[256] = { + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15, 0,15,15, + 15, 1,14, 2,13,15,15, 4,11,15,15,12,15, 3,15,15, + 15,15, 5, 6, 8,15, 7, 9,15,10,15,15,15,15,15,15, + 15, 1,14, 2,13,15,15, 4,11,15,15,12,15, 3,15,15, + 15,15, 5, 6, 8,15, 7, 9,15,10,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15, + 15,15,15,15,15,15,15,15,15,15,15,15,15,15,15,15 + }; + bam1_t *b = (bam1_t *)*bp; + uint8_t *cp; + int i, bam_len; + + //b->l_aux = extra_len; // we fill this out later + + bam_len = qname_len + 1 + ncigar*4 + (len+1)/2 + len + extra_len; + if (b->m_data < bam_len) { + b->m_data = bam_len; + kroundup32(b->m_data); + b->data = (uint8_t*)realloc(b->data, b->m_data); + if (!b->data) + return -1; + } + b->l_data = bam_len; + + b->core.tid = rname; + b->core.pos = pos-1; + b->core.bin = bam_reg2bin(pos, end); + b->core.qual = mapq; + b->core.l_qname = qname_len+1; + b->core.flag = flag; + b->core.n_cigar = ncigar; + b->core.l_qseq = len; + b->core.mtid = mrnm; + b->core.mpos = mpos-1; + b->core.isize = isize; + + cp = b->data; + + strncpy((char *)cp, qname, qname_len); + cp[qname_len] = 0; + cp += qname_len+1; + memcpy(cp, cigar, ncigar*4); + cp += ncigar*4; + + for (i = 0; i+1 < len; i+=2) { + *cp++ = (L[(uc)seq[i]]<<4) + L[(uc)seq[i+1]]; + } + if (i < len) + *cp++ = L[(uc)seq[i]]<<4; + + if (qual) + memcpy(cp, qual, len); + else + memset(cp, '\xff', len); + + return 0; +} + +bam_hdr_t *cram_header_to_bam(SAM_hdr *h) { + int i; + bam_hdr_t *header = bam_hdr_init(); + + header->l_text = ks_len(&h->text); + header->text = malloc(header->l_text+1); + memcpy(header->text, ks_str(&h->text), header->l_text); + header->text[header->l_text] = 0; + + header->n_targets = h->nref; + header->target_name = (char **)calloc(header->n_targets, + sizeof(char *)); + header->target_len = (uint32_t *)calloc(header->n_targets, 4); + + for (i = 0; i < h->nref; i++) { + header->target_name[i] = strdup(h->ref[i].name); + header->target_len[i] = h->ref[i].len; + } + + return header; +} + +SAM_hdr *bam_header_to_cram(bam_hdr_t *h) { + return sam_hdr_parse_(h->text, h->l_text); +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_samtools.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,97 @@ +/* +Copyright (c) 2010-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _CRAM_SAMTOOLS_H_ +#define _CRAM_SAMTOOLS_H_ + +/* Samtools compatible API */ +#define bam_blk_size(b) ((b)->l_data) +#define bam_set_blk_size(b,v) ((b)->data_len = (v)) + +#define bam_ref(b) (b)->core.tid +#define bam_pos(b) (b)->core.pos +#define bam_mate_pos(b) (b)->core.mpos +#define bam_mate_ref(b) (b)->core.mtid +#define bam_ins_size(b) (b)->core.isize +#define bam_seq_len(b) (b)->core.l_qseq +#define bam_cigar_len(b) (b)->core.n_cigar +#define bam_flag(b) (b)->core.flag +#define bam_bin(b) (b)->core.bin +#define bam_map_qual(b) (b)->core.qual +#define bam_name_len(b) (b)->core.l_qname +#define bam_name(b) bam_get_qname((b)) +#define bam_qual(b) bam_get_qual((b)) +#define bam_seq(b) bam_get_seq((b)) +#define bam_cigar(b) bam_get_cigar((b)) +#define bam_aux(b) bam_get_aux((b)) + +#define bam_dup(b) bam_copy1(bam_init1(), (b)) + +#define bam_free(b) bam_destroy1((b)) + +#define bam_reg2bin(beg,end) hts_reg2bin((beg),(end),14,5) + +#include "htslib/sam.h" + +enum cigar_op { + BAM_CMATCH_=BAM_CMATCH, + BAM_CINS_=BAM_CINS, + BAM_CDEL_=BAM_CDEL, + BAM_CREF_SKIP_=BAM_CREF_SKIP, + BAM_CSOFT_CLIP_=BAM_CSOFT_CLIP, + BAM_CHARD_CLIP_=BAM_CHARD_CLIP, + BAM_CPAD_=BAM_CPAD, + BAM_CBASE_MATCH=BAM_CEQUAL, + BAM_CBASE_MISMATCH=BAM_CDIFF +}; + +typedef bam1_t bam_seq_t; + +#include "cram/sam_header.h" + +bam_hdr_t *cram_header_to_bam(SAM_hdr *h); +SAM_hdr *bam_header_to_cram(bam_hdr_t *h); + +int bam_construct_seq(bam_seq_t **bp, size_t extra_len, + const char *qname, size_t qname_len, + int flag, + int rname, // Ref ID + int pos, + int end, // aligned start/end coords + int mapq, + uint32_t ncigar, const uint32_t *cigar, + int mrnm, // Mate Ref ID + int mpos, + int isize, + int len, + const char *seq, + const char *qual); + +#endif /* _CRAM_SAMTOOLS_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_stats.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,450 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdio.h> +#include <errno.h> +#include <assert.h> +#include <stdlib.h> +#include <string.h> +#include <zlib.h> +#include <sys/types.h> +#include <sys/stat.h> +#include <math.h> +#include <ctype.h> + +#include "cram/cram.h" +#include "cram/os.h" + +cram_stats *cram_stats_create(void) { + return calloc(1, sizeof(cram_stats)); +} + +void cram_stats_add(cram_stats *st, int32_t val) { + st->nsamp++; + + //assert(val >= 0); + + if (val < MAX_STAT_VAL && val >= 0) { + st->freqs[val]++; + } else { + khint_t k; + int r; + + if (!st->h) { + st->h = kh_init(m_i2i); + } + + k = kh_put(m_i2i, st->h, val, &r); + if (r == 0) + kh_val(st->h, k)++; + else if (r != -1) + kh_val(st->h, k) = 1; + else + ; // FIXME: handle error + } +} + +void cram_stats_del(cram_stats *st, int32_t val) { + st->nsamp--; + + //assert(val >= 0); + + if (val < MAX_STAT_VAL && val >= 0) { + st->freqs[val]--; + assert(st->freqs[val] >= 0); + } else if (st->h) { + khint_t k = kh_get(m_i2i, st->h, val); + + if (k != kh_end(st->h)) { + if (--kh_val(st->h, k) == 0) + kh_del(m_i2i, st->h, k); + } else { + fprintf(stderr, "Failed to remove val %d from cram_stats\n", val); + st->nsamp++; + } + } else { + fprintf(stderr, "Failed to remove val %d from cram_stats\n", val); + st->nsamp++; + } +} + +void cram_stats_dump(cram_stats *st) { + int i; + fprintf(stderr, "cram_stats:\n"); + for (i = 0; i < MAX_STAT_VAL; i++) { + if (!st->freqs[i]) + continue; + fprintf(stderr, "\t%d\t%d\n", i, st->freqs[i]); + } + if (st->h) { + khint_t k; + for (k = kh_begin(st->h); k != kh_end(st->h); k++) { + if (!kh_exist(st->h, k)) + continue; + + fprintf(stderr, "\t%d\t%d\n", kh_key(st->h, k), kh_val(st->h, k)); + } + } +} + +#if 1 +/* Returns the number of bits set in val; it the highest bit used */ +static int nbits(int v) { + static const int MultiplyDeBruijnBitPosition[32] = { + 1, 10, 2, 11, 14, 22, 3, 30, 12, 15, 17, 19, 23, 26, 4, 31, + 9, 13, 21, 29, 16, 18, 25, 8, 20, 28, 24, 7, 27, 6, 5, 32 + }; + + v |= v >> 1; // first up to set all bits 1 after the first 1 */ + v |= v >> 2; + v |= v >> 4; + v |= v >> 8; + v |= v >> 16; + + // DeBruijn magic to find top bit + return MultiplyDeBruijnBitPosition[(uint32_t)(v * 0x07C4ACDDU) >> 27]; +} +#endif + +/* + * Computes entropy from integer frequencies for various encoding methods and + * picks the best encoding. + * + * FIXME: we could reuse some of the code here for the actual encoding + * parameters too. Eg the best 'k' for SUBEXP or the code lengths for huffman. + * + * Returns the best codec to use. + */ +enum cram_encoding cram_stats_encoding(cram_fd *fd, cram_stats *st) { + enum cram_encoding best_encoding = E_NULL; + int best_size = INT_MAX, bits; + int nvals, i, ntot = 0, max_val = 0, min_val = INT_MAX, k; + int *vals = NULL, *freqs = NULL, vals_alloc = 0, *codes; + + //cram_stats_dump(st); + + /* Count number of unique symbols */ + for (nvals = i = 0; i < MAX_STAT_VAL; i++) { + if (!st->freqs[i]) + continue; + if (nvals >= vals_alloc) { + vals_alloc = vals_alloc ? vals_alloc*2 : 1024; + vals = realloc(vals, vals_alloc * sizeof(int)); + freqs = realloc(freqs, vals_alloc * sizeof(int)); + if (!vals || !freqs) { + if (vals) free(vals); + if (freqs) free(freqs); + return E_HUFFMAN; // Cannot do much else atm + } + } + vals[nvals] = i; + freqs[nvals] = st->freqs[i]; + ntot += freqs[nvals]; + if (max_val < i) max_val = i; + if (min_val > i) min_val = i; + nvals++; + } + if (st->h) { + khint_t k; + int i; + + for (k = kh_begin(st->h); k != kh_end(st->h); k++) { + if (!kh_exist(st->h, k)) + continue; + + if (nvals >= vals_alloc) { + vals_alloc = vals_alloc ? vals_alloc*2 : 1024; + vals = realloc(vals, vals_alloc * sizeof(int)); + freqs = realloc(freqs, vals_alloc * sizeof(int)); + if (!vals || !freqs) + return E_HUFFMAN; // Cannot do much else atm + } + i = kh_key(st->h, k); + vals[nvals]=i; + freqs[nvals] = kh_val(st->h, k); + ntot += freqs[nvals]; + if (max_val < i) max_val = i; + if (min_val > i) min_val = i; + nvals++; + } + } + + st->nvals = nvals; + assert(ntot == st->nsamp); + + if (nvals <= 1) { + free(vals); + free(freqs); + return E_HUFFMAN; + } + + if (fd->verbose > 1) + fprintf(stderr, "Range = %d..%d, nvals=%d, ntot=%d\n", + min_val, max_val, nvals, ntot); + + /* Theoretical entropy */ +// if (fd->verbose > 1) { +// double dbits = 0; +// for (i = 0; i < nvals; i++) { +// dbits += freqs[i] * log((double)freqs[i]/ntot); +// } +// dbits /= -log(2); +// if (fd->verbose > 1) +// fprintf(stderr, "Entropy = %f\n", dbits); +// } + + if (nvals > 1 && ntot > 256) { +#if 0 + /* + * CRUDE huffman estimator. Round to closest and round up from 0 + * to 1 bit. + * + * With and without ITF8 incase we have a few discrete values but with + * large magnitude. + * + * Note rans0/arith0 and Z_HUFFMAN_ONLY vs internal huffman can be + * compared in this way, but order-1 (eg rans1) or maybe LZ77 modes + * may detect the correlation of high bytes to low bytes in multi- + * byte values. So this predictor breaks down. + */ + double dbits = 0; // entropy + ~huffman + double dbitsH = 0; + double dbitsE = 0; // external entropy + ~huffman + double dbitsEH = 0; + int F[256] = {0}, n = 0; + double e = 0; // accumulated error bits + for (i = 0; i < nvals; i++) { + double x; int X; + unsigned int v = vals[i]; + + //Better encoding would cope with sign. + //v = ABS(vals[i])*2+(vals[i]<0); + + if (!(v & ~0x7f)) { + F[v] += freqs[i], n+=freqs[i]; + } else if (!(v & ~0x3fff)) { + F[(v>>8) |0x80] += freqs[i]; + F[ v &0xff] += freqs[i], n+=2*freqs[i]; + } else if (!(v & ~0x1fffff)) { + F[(v>>16)|0xc0] += freqs[i]; + F[(v>>8 )&0xff] += freqs[i]; + F[ v &0xff] += freqs[i], n+=3*freqs[i]; + } else if (!(v & ~0x0fffffff)) { + F[(v>>24)|0xe0] += freqs[i]; + F[(v>>16)&0xff] += freqs[i]; + F[(v>>8 )&0xff] += freqs[i]; + F[ v &0xff] += freqs[i], n+=4*freqs[i]; + } else { + F[(v>>28)|0xf0] += freqs[i]; + F[(v>>20)&0xff] += freqs[i]; + F[(v>>12)&0xff] += freqs[i]; + F[(v>>4 )&0xff] += freqs[i]; + F[ v &0x0f] += freqs[i], n+=5*freqs[i]; + } + + x = -log((double)freqs[i]/ntot)/.69314718055994530941; + X = x+0.5; + if ((int)(x+((double)e/freqs[i])+.5)>X) { + X++; + } else if ((int)(x+((double)e/freqs[i])+.5)<X) { + X--; + } + e-=freqs[i]*(X-x); + X += (X==0); + + //fprintf(stderr, "Val %d = %d x %d (ent %f, %d) e %f\n", i, v, freqs[i], x, X, e); + + dbits += freqs[i] * x; + dbitsH += freqs[i] * X; + } + + for (i = 0; i < 256; i++) { + if (F[i]) { + double x = -log((double)F[i]/n)/.69314718055994530941; + int X = x+0.5; + X += (X==0); + dbitsE += F[i] * x; + dbitsEH += F[i] * X; + + //fprintf(stderr, "Val %d = %d x %d (e %f, %d)\n", i, i, F[i], x, X); + } + } + + //fprintf(stderr, "CORE Entropy = %f, %f\n", dbits/8, dbitsH/8); + //fprintf(stderr, "Ext. Entropy = %f, %f\n", dbitsE/8, dbitsEH/8); + + if (dbitsE < 1000 || dbitsE / dbits > 1.1) { + //fprintf(stderr, "=> %d < 200 ? E_HUFFMAN : E_BETA\n", nvals); + free(vals); free(freqs); + return nvals < 200 ? E_HUFFMAN : E_BETA; + } +#endif + free(vals); free(freqs); + return E_EXTERNAL; + } + + /* + * Avoid complex stats for now, just do heuristic of HUFFMAN for small + * alphabets and BETA for anything large. + */ + free(vals); free(freqs); + return nvals < 200 ? E_HUFFMAN : E_BETA; + //return E_HUFFMAN; + //return E_EXTERNAL; + + + /* We only support huffman now anyway... */ + //free(vals); free(freqs); return E_HUFFMAN; + + /* Beta */ + bits = nbits(max_val - min_val) * ntot; + if (fd->verbose > 1) + fprintf(stderr, "BETA = %d\n", bits); + if (best_size > bits) + best_size = bits, best_encoding = E_BETA; + +#if 0 + /* Unary */ + if (min_val >= 0) { + for (bits = i = 0; i < nvals; i++) + bits += freqs[i]*(vals[i]+1); + if (fd->verbose > 1) + fprintf(stderr, "UNARY = %d\n", bits); + if (best_size > bits) + best_size = bits, best_encoding = E_NULL; //E_UNARY; + } + + /* Gamma */ + for (bits = i = 0; i < nvals; i++) + bits += ((nbits(vals[i]-min_val+1)-1) + nbits(vals[i]-min_val+1)) * freqs[i]; + if (fd->verbose > 1) + fprintf(stderr, "GAMMA = %d\n", bits); + if (best_size > bits) + best_size = bits, best_encoding = E_GAMMA; + + /* Subexponential */ + for (k = 0; k < 10; k++) { + for (bits = i = 0; i < nvals; i++) { + if (vals[i]-min_val < (1<<k)) + bits += (1 + k)*freqs[i]; + else + bits += (nbits(vals[i]-min_val)*2-k)*freqs[i]; + } + + if (fd->verbose > 1) + fprintf(stderr, "SUBEXP%d = %d\n", k, bits); + if (best_size > bits) + best_size = bits, best_encoding = E_SUBEXP; + } +#endif + + /* byte array len */ + + /* byte array stop */ + + /* External? Guesswork! */ + + /* Huffman */ +// qsort(freqs, nvals, sizeof(freqs[0]), sort_freqs); +// for (i = 0; i < nvals; i++) { +// fprintf(stderr, "%d = %d\n", i, freqs[i]); +// vals[i] = 0; +// } + + /* Grow freqs to 2*freqs, to store sums */ + /* Vals holds link data */ + freqs = realloc(freqs, 2*nvals*sizeof(*freqs)); + codes = calloc(2*nvals, sizeof(*codes)); + if (!freqs || !codes) + return E_HUFFMAN; // Cannot do much else atm + + /* Inefficient, use pointers to form chain so we can insert and maintain + * a sorted list? This is currently O(nvals^2) complexity. + */ + for (;;) { + int low1 = INT_MAX, low2 = INT_MAX; + int ind1 = 0, ind2 = 0; + for (i = 0; i < nvals; i++) { + if (freqs[i] < 0) + continue; + if (low1 > freqs[i]) + low2 = low1, ind2 = ind1, low1 = freqs[i], ind1 = i; + else if (low2 > freqs[i]) + low2 = freqs[i], ind2 = i; + } + if (low2 == INT_MAX) + break; + + //fprintf(stderr, "Merge ind %d (%d), %d (%d) = %d+%d, => %d=%d\n", + // ind1, vals[ind1], ind2, vals[ind2], low1, low2, + // nvals, low1+low2); + + freqs[nvals] = low1 + low2; + codes[ind1] = nvals; + codes[ind2] = nvals; + freqs[ind1] *= -1; + freqs[ind2] *= -1; + nvals++; + } + nvals = nvals/2+1; + + for (i = 0; i < nvals; i++) { + int code_len = 0; + for (k = codes[i]; k; k = codes[k]) + code_len++; + codes[i] = code_len; + freqs[i] *= -1; + //fprintf(stderr, "%d / %d => %d\n", vals[i], freqs[i], codes[i]); + } + + for (bits = i = 0; i < nvals; i++) { + bits += freqs[i] * codes[i]; + } + if (fd->verbose > 1) + fprintf(stderr, "HUFFMAN = %d\n", bits); + if (best_size >= bits) + best_size = bits, best_encoding = E_HUFFMAN; + free(codes); + + free(vals); + free(freqs); + + return best_encoding; +} + +void cram_stats_free(cram_stats *st) { + if (st->h) + kh_destroy(m_i2i, st->h); + free(st); +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_stats.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,59 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _CRAM_STATS_H_ +#define _CRAM_STATS_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +cram_stats *cram_stats_create(void); +void cram_stats_add(cram_stats *st, int32_t val); +void cram_stats_del(cram_stats *st, int32_t val); +void cram_stats_dump(cram_stats *st); +void cram_stats_free(cram_stats *st); + +/* + * Computes entropy from integer frequencies for various encoding methods and + * picks the best encoding. + * + * FIXME: we could reuse some of the code here for the actual encoding + * parameters too. Eg the best 'k' for SUBEXP or the code lengths for huffman. + * + * Returns the best codec to use. + */ +enum cram_encoding cram_stats_encoding(cram_fd *fd, cram_stats *st); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/cram_structs.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,809 @@ +/* +Copyright (c) 2012-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _CRAM_STRUCTS_H_ +#define _CRAM_STRUCTS_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +/* + * Defines in-memory structs for the basic file-format objects in the + * CRAM format. + * + * The basic file format is: + * File-def SAM-hdr Container Container ... + * + * Container: + * Service-block data-block data-block ... + * + * Multiple blocks in a container are grouped together as slices, + * also sometimes referred to as landmarks in the spec. + */ + + +#include <stdint.h> + +#include "cram/thread_pool.h" +#include "cram/string_alloc.h" +#include "htslib/khash.h" + +// Generic hash-map integer -> integer +KHASH_MAP_INIT_INT(m_i2i, int) + +// Generic hash-set integer -> (existance) +KHASH_SET_INIT_INT(s_i2i) + +// For brevity +typedef unsigned char uc; + +/* + * A union for the preservation map. Required for khash. + */ +typedef union { + int i; + char *p; +} pmap_t; + +// Generates static functions here which isn't ideal, but we have no way +// currently to declare the kh_map_t structure here without also declaring a +// duplicate in the .c files due to the nature of the KHASH macros. +KHASH_MAP_INIT_STR(map, pmap_t) + +struct hFILE; + +#define SEQS_PER_SLICE 10000 +#define SLICE_PER_CNT 1 + +#define CRAM_SUBST_MATRIX "CGTNAGTNACTNACGNACGT" + +#define MAX_STAT_VAL 1024 +//#define MAX_STAT_VAL 16 +typedef struct { + int freqs[MAX_STAT_VAL]; + khash_t(m_i2i) *h; + int nsamp; // total number of values added + int nvals; // total number of unique values added +} cram_stats; + +/* NB: matches java impl, not the spec */ +enum cram_encoding { + E_NULL = 0, + E_EXTERNAL = 1, + E_GOLOMB = 2, + E_HUFFMAN = 3, + E_BYTE_ARRAY_LEN = 4, + E_BYTE_ARRAY_STOP = 5, + E_BETA = 6, + E_SUBEXP = 7, + E_GOLOMB_RICE = 8, + E_GAMMA = 9 +}; + +enum cram_external_type { + E_INT = 1, + E_LONG = 2, + E_BYTE = 3, + E_BYTE_ARRAY = 4, + E_BYTE_ARRAY_BLOCK = 5, +}; + +/* External IDs used by this implementation (only assumed during writing) */ +enum cram_DS_ID { + DS_CORE = 0, + DS_aux = 1, // aux_blk + DS_aux_OQ = 2, + DS_aux_BQ = 3, + DS_aux_BD = 4, + DS_aux_BI = 5, + DS_aux_FZ = 6, // also ZM:B + DS_aux_oq = 7, // other qualities + DS_aux_os = 8, // other sequences + DS_aux_oz = 9, // other strings + DS_ref, + DS_RN, // name_blk + DS_QS, // qual_blk + DS_IN, // base_blk + DS_SC, // soft_blk + + DS_BF, // start loop + DS_CF, + DS_AP, + DS_RG, + DS_MQ, + DS_NS, + DS_MF, + DS_TS, + DS_NP, + DS_NF, + DS_RL, + DS_FN, + DS_FC, + DS_FP, + DS_DL, + DS_BA, + DS_BS, + DS_TL, + DS_RI, + DS_RS, + DS_PD, + DS_HC, + DS_BB, + DS_QQ, + + DS_TN, // end loop + + DS_RN_len, + DS_SC_len, + DS_BB_len, + DS_QQ_len, + + DS_TC, // CRAM v1.0 tags + DS_TM, // test + DS_TV, // test + + DS_END, +}; + +/* "File Definition Structure" */ +typedef struct { + char magic[4]; + uint8_t major_version; + uint8_t minor_version; + char file_id[20]; // Filename or SHA1 checksum +} cram_file_def; + +#define CRAM_MAJOR_VERS(v) ((v) >> 8) +#define CRAM_MINOR_VERS(v) ((v) & 0xff) + +struct cram_slice; + +enum cram_block_method { + ERROR = -1, + RAW = 0, + GZIP = 1, + BZIP2 = 2, + LZMA = 3, + RANS = 4, // Generic; either order + RANS0 = 4, + RANS1 = 10, // Not externalised; stored as RANS (generic) + GZIP_RLE = 11, // NB: not externalised in CRAM +}; + +enum cram_content_type { + CT_ERROR = -1, + FILE_HEADER = 0, + COMPRESSION_HEADER = 1, + MAPPED_SLICE = 2, + UNMAPPED_SLICE = 3, // CRAM V1.0 only + EXTERNAL = 4, + CORE = 5, +}; + +/* Compression metrics */ +typedef struct { + // number of trials and time to next trial + int trial; + int next_trial; + + // aggregate sizes during trials + int sz_gz_rle; + int sz_gz_def; + int sz_rans0; + int sz_rans1; + int sz_bzip2; + int sz_lzma; + + // resultant method from trials + int method; + int strat; + + // Revisions of method, to allow culling of continually failing ones. + int gz_rle_cnt; + int gz_def_cnt; + int rans0_cnt; + int rans1_cnt; + int bzip2_cnt; + int lzma_cnt; + int revised_method; + + double gz_rle_extra; + double gz_def_extra; + double rans0_extra; + double rans1_extra; + double bzip2_extra; + double lzma_extra; +} cram_metrics; + +/* Block */ +typedef struct { + enum cram_block_method method, orig_method; + enum cram_content_type content_type; + int32_t content_id; + int32_t comp_size; + int32_t uncomp_size; + uint32_t crc32; + int32_t idx; /* offset into data */ + unsigned char *data; + + // For bit I/O + size_t alloc; + size_t byte; + int bit; +} cram_block; + +struct cram_codec; /* defined in cram_codecs.h */ +struct cram_map; + +#define CRAM_MAP_HASH 32 +#define CRAM_MAP(a,b) (((a)*3+(b))&(CRAM_MAP_HASH-1)) + +/* Compression header block */ +typedef struct { + int32_t ref_seq_id; + int32_t ref_seq_start; + int32_t ref_seq_span; + int32_t num_records; + int32_t num_landmarks; + int32_t *landmark; + + /* Flags from preservation map */ + int mapped_qs_included; + int unmapped_qs_included; + int unmapped_placed; + int qs_included; + int read_names_included; + int AP_delta; + // indexed by ref-base and subst. code + char substitution_matrix[5][4]; + + // TD Dictionary as a concatenated block + cram_block *TD_blk; // Tag Dictionary + int nTL; // number of TL entries in TD + unsigned char **TL; // array of size nTL, pointer into TD_blk. + khash_t(m_s2i) *TD_hash; // Keyed on TD strings, map to TL[] indices + string_alloc_t *TD_keys; // Pooled keys for TD hash. + + khash_t(map) *preservation_map; + struct cram_map *rec_encoding_map[CRAM_MAP_HASH]; + struct cram_map *tag_encoding_map[CRAM_MAP_HASH]; + + struct cram_codec *codecs[DS_END]; + + char *uncomp; // A single block of uncompressed data + size_t uncomp_size, uncomp_alloc; + + unsigned int data_series; // See cram_fields enum below +} cram_block_compression_hdr; + +typedef struct cram_map { + int key; /* 0xe0 + 3 bytes */ + enum cram_encoding encoding; + int offset; /* Offset into a single block of memory */ + int size; /* Size */ + struct cram_codec *codec; + struct cram_map *next; // for noddy internal hash +} cram_map; + +/* Mapped or unmapped slice header block */ +typedef struct { + enum cram_content_type content_type; + int32_t ref_seq_id; /* if content_type == MAPPED_SLICE */ + int32_t ref_seq_start; /* if content_type == MAPPED_SLICE */ + int32_t ref_seq_span; /* if content_type == MAPPED_SLICE */ + int32_t num_records; + int64_t record_counter; + int32_t num_blocks; + int32_t num_content_ids; + int32_t *block_content_ids; + int32_t ref_base_id; /* if content_type == MAPPED_SLICE */ + unsigned char md5[16]; +} cram_block_slice_hdr; + +struct ref_entry; + +/* + * Container. + * + * Conceptually a container is split into slices, and slices into blocks. + * However on disk it's just a list of blocks and we need to query the + * block types to identify the start/end points of the slices. + * + * OR... are landmarks the start/end points of slices? + */ +typedef struct { + int32_t length; + int32_t ref_seq_id; + int32_t ref_seq_start; + int32_t ref_seq_span; + int64_t record_counter; + int64_t num_bases; + int32_t num_records; + int32_t num_blocks; + int32_t num_landmarks; + int32_t *landmark; + + /* Size of container header above */ + size_t offset; + + /* Compression header is always the first block? */ + cram_block_compression_hdr *comp_hdr; + cram_block *comp_hdr_block; + + /* For construction purposes */ + int max_slice, curr_slice; // maximum number of slices + int max_rec, curr_rec; // current and max recs per slice + int max_c_rec, curr_c_rec; // current and max recs per container + int slice_rec; // rec no. for start of this slice + int curr_ref; // current ref ID. -2 for no previous + int last_pos; // last record position + struct cram_slice **slices, *slice; + int pos_sorted; // boolean, 1=>position sorted data + int max_apos; // maximum position, used if pos_sorted==0 + int last_slice; // number of reads in last slice (0 for 1st) + int multi_seq; // true if packing multi seqs per cont/slice + int unsorted; // true is AP_delta is 0. + + /* Copied from fd before encoding, to allow multi-threading */ + int ref_start, first_base, last_base, ref_id, ref_end; + char *ref; + //struct ref_entry *ref; + + /* For multi-threading */ + bam_seq_t **bams; + + /* Statistics for encoding */ + cram_stats *stats[DS_END]; + + khash_t(s_i2i) *tags_used; // set of tag types in use, for tag encoding map + int *refs_used; // array of frequency of ref seq IDs + + uint32_t crc32; // CRC32 +} cram_container; + +/* + * A single cram record + */ +typedef struct { + struct cram_slice *s; // Filled out by cram_decode only + + int32_t ref_id; // fixed for all recs in slice? + int32_t flags; // BF + int32_t cram_flags; // CF + int32_t len; // RL + int32_t apos; // AP + int32_t rg; // RG + int32_t name; // RN; idx to s->names_blk + int32_t name_len; + int32_t mate_line; // index to another cram_record + int32_t mate_ref_id; + int32_t mate_pos; // NP + int32_t tlen; // TS + + // Auxiliary data + int32_t ntags; // TC + int32_t aux; // idx to s->aux_blk + int32_t aux_size; // total size of packed ntags in aux_blk +#ifndef TN_external + int32_t TN_idx; // TN; idx to s->TN; +#else + int32_t tn; // idx to s->tn_blk +#endif + int TL; + + int32_t seq; // idx to s->seqs_blk + int32_t qual; // idx to s->qual_blk + int32_t cigar; // idx to s->cigar + int32_t ncigar; + int32_t aend; // alignment end + int32_t mqual; // MQ + + int32_t feature; // idx to s->feature + int32_t nfeature; // number of features + int32_t mate_flags; // MF +} cram_record; + +// Accessor macros as an analogue of the bam ones +#define cram_qname(c) (&(c)->s->name_blk->data[(c)->name]) +#define cram_seq(c) (&(c)->s->seqs_blk->data[(c)->seq]) +#define cram_qual(c) (&(c)->s->qual_blk->data[(c)->qual]) +#define cram_aux(c) (&(c)->s->aux_blk->data[(c)->aux]) +#define cram_seqi(c,i) (cram_seq((c))[(i)]) +#define cram_name_len(c) ((c)->name_len) +#define cram_strand(c) (((c)->flags & BAM_FREVERSE) != 0) +#define cram_mstrand(c) (((c)->flags & BAM_FMREVERSE) != 0) +#define cram_cigar(c) (&((cr)->s->cigar)[(c)->cigar]) + +/* + * A feature is a base difference, used for the sequence reference encoding. + * (We generate these internally when writing CRAM.) + */ +typedef struct { + union { + struct { + int pos; + int code; + int base; // substitution code + } X; + struct { + int pos; + int code; + int base; // actual base & qual + int qual; + } B; + struct { + int pos; + int code; + int seq_idx; // index to s->seqs_blk + int len; + } b; + struct { + int pos; + int code; + int qual; + } Q; + struct { + int pos; + int code; + int len; + int seq_idx; // soft-clip multiple bases + } S; + struct { + int pos; + int code; + int len; + int seq_idx; // insertion multiple bases + } I; + struct { + int pos; + int code; + int base; // insertion single base + } i; + struct { + int pos; + int code; + int len; + } D; + struct { + int pos; + int code; + int len; + } N; + struct { + int pos; + int code; + int len; + } P; + struct { + int pos; + int code; + int len; + } H; + }; +} cram_feature; + +/* + * A slice is really just a set of blocks, but it + * is the logical unit for decoding a number of + * sequences. + */ +typedef struct cram_slice { + cram_block_slice_hdr *hdr; + cram_block *hdr_block; + cram_block **block; + cram_block **block_by_id; + + /* State used during encoding/decoding */ + int last_apos, max_apos; + + /* Array of decoded cram records */ + cram_record *crecs; + + /* An dynamically growing buffers for data pointed + * to by crecs[] array. + */ + uint32_t *cigar; + uint32_t cigar_alloc; + uint32_t ncigar; + + cram_feature *features; + int nfeatures; + int afeatures; // allocated size of features + +#ifndef TN_external + // TN field (Tag Name) + uint32_t *TN; + int nTN, aTN; // used and allocated size for TN[] +#else + cram_block *tn_blk; + int tn_id; +#endif + + // For variable sized elements which are always external blocks. + cram_block *name_blk; + cram_block *seqs_blk; + cram_block *qual_blk; + cram_block *base_blk; + cram_block *soft_blk; + cram_block *aux_blk; + cram_block *aux_OQ_blk; + cram_block *aux_BQ_blk; + cram_block *aux_BD_blk; + cram_block *aux_BI_blk; + cram_block *aux_FZ_blk; + cram_block *aux_oq_blk; + cram_block *aux_os_blk; + cram_block *aux_oz_blk; + + string_alloc_t *pair_keys; // Pooled keys for pair hash. + khash_t(m_s2i) *pair[2]; // for identifying read-pairs in this slice. + + char *ref; // slice of current reference + int ref_start; // start position of current reference; + int ref_end; // end position of current reference; + int ref_id; +} cram_slice; + +/*----------------------------------------------------------------------------- + * Consider moving reference handling to cram_refs.[ch] + */ +// from fa.fai / samtools faidx files +typedef struct ref_entry { + char *name; + char *fn; + int64_t length; + int64_t offset; + int bases_per_line; + int line_length; + int64_t count; // for shared references so we know to dealloc seq + char *seq; +} ref_entry; + +KHASH_MAP_INIT_STR(refs, ref_entry*) + +// References structure. +typedef struct { + string_alloc_t *pool; // String pool for holding filenames and SN vals + + khash_t(refs) *h_meta; // ref_entry*, index by name + ref_entry **ref_id; // ref_entry*, index by ID + int nref; // number of ref_entry + + char *fn; // current file opened + BGZF *fp; // and the hFILE* to go with it. + + int count; // how many cram_fd sharing this refs struct + + pthread_mutex_t lock; // Mutex for multi-threaded updating + ref_entry *last; // Last queried sequence + int last_id; // Used in cram_ref_decr_locked to delay free +} refs_t; + +/*----------------------------------------------------------------------------- + * CRAM index + * + * Detect format by number of entries per line. + * 5 => 1.0 (refid, start, nseq, C offset, slice) + * 6 => 1.1 (refid, start, span, C offset, S offset, S size) + * + * Indices are stored in a nested containment list, which is trivial to set + * up as the indices are on sorted data so we're appending to the nclist + * in sorted order. Basically if a slice entirely fits within a previous + * slice then we append to that slices list. This is done recursively. + * + * Lists are sorted on two dimensions: ref id + slice coords. + */ +typedef struct cram_index { + int nslice, nalloc; // total number of slices + struct cram_index *e; // array of size nslice + + int refid; // 1.0 1.1 + int start; // 1.0 1.1 + int end; // 1.1 + int nseq; // 1.0 - undocumented + int slice; // 1.0 landmark index, 1.1 landmark value + int len; // 1.1 - size of slice in bytes + int64_t offset; // 1.0 1.1 +} cram_index; + +typedef struct { + int refid; + int start; + int end; +} cram_range; + +/*----------------------------------------------------------------------------- + */ +/* CRAM File handle */ + +typedef struct spare_bams { + bam_seq_t **bams; + struct spare_bams *next; +} spare_bams; + +typedef struct cram_fd { + struct hFILE *fp; + int mode; // 'r' or 'w' + int version; + cram_file_def *file_def; + SAM_hdr *header; + + char *prefix; + int64_t record_counter; + int err; + + // Most recent compression header decoded + //cram_block_compression_hdr *comp_hdr; + //cram_block_slice_hdr *slice_hdr; + + // Current container being processed. + cram_container *ctr; + + // positions for encoding or decoding + int first_base, last_base; + + // cached reference portion + refs_t *refs; // ref meta-data structure + char *ref, *ref_free; // current portion held in memory + int ref_id; + int ref_start; + int ref_end; + char *ref_fn; // reference fasta filename + + // compression level and metrics + int level; + cram_metrics *m[DS_END]; + + // options + int decode_md; // Whether to export MD and NM tags + int verbose; + int seqs_per_slice; + int slices_per_container; + int embed_ref; + int no_ref; + int ignore_md5; + int use_bz2; + int use_rans; + int use_lzma; + int shared_ref; + unsigned int required_fields; + cram_range range; + + // lookup tables, stored here so we can be trivially multi-threaded + unsigned int bam_flag_swap[0x1000]; // cram -> bam flags + unsigned int cram_flag_swap[0x1000];// bam -> cram flags + unsigned char L1[256]; // ACGT{*} ->0123{4} + unsigned char L2[256]; // ACGTN{*}->01234{5} + char cram_sub_matrix[32][32]; // base substituion codes + + int index_sz; + cram_index *index; // array, sizeof index_sz + off_t first_container; + int eof; + int last_slice; // number of recs encoded in last slice + int multi_seq; + int unsorted; + int empty_container; // Marker for EOF block + + // thread pool + int own_pool; + t_pool *pool; + t_results_queue *rqueue; + pthread_mutex_t metrics_lock; + pthread_mutex_t ref_lock; + spare_bams *bl; + pthread_mutex_t bam_list_lock; + void *job_pending; + int ooc; // out of containers. +} cram_fd; + +// Translation of required fields to cram data series +enum cram_fields { + CRAM_BF = 0x00000001, + CRAM_AP = 0x00000002, + CRAM_FP = 0x00000004, + CRAM_RL = 0x00000008, + CRAM_DL = 0x00000010, + CRAM_NF = 0x00000020, + CRAM_BA = 0x00000040, + CRAM_QS = 0x00000080, + CRAM_FC = 0x00000100, + CRAM_FN = 0x00000200, + CRAM_BS = 0x00000400, + CRAM_IN = 0x00000800, + CRAM_RG = 0x00001000, + CRAM_MQ = 0x00002000, + CRAM_TL = 0x00004000, + CRAM_RN = 0x00008000, + CRAM_NS = 0x00010000, + CRAM_NP = 0x00020000, + CRAM_TS = 0x00040000, + CRAM_MF = 0x00080000, + CRAM_CF = 0x00100000, + CRAM_RI = 0x00200000, + CRAM_RS = 0x00400000, + CRAM_PD = 0x00800000, + CRAM_HC = 0x01000000, + CRAM_SC = 0x02000000, + CRAM_BB = 0x04000000, + CRAM_BB_len = 0x08000000, + CRAM_QQ = 0x10000000, + CRAM_QQ_len = 0x20000000, + CRAM_aux= 0x40000000, + CRAM_ALL= 0x7fffffff, +}; + +// A CIGAR opcode, but not necessarily the implications of it. Eg FC/FP may +// encode a base difference, but we don't need to know what it is for CIGAR. +// If we have a soft-clip or insertion, we do need SC/IN though to know how +// long that array is. +#define CRAM_CIGAR (CRAM_FN | CRAM_FP | CRAM_FC | CRAM_DL | CRAM_IN | \ + CRAM_SC | CRAM_HC | CRAM_PD | CRAM_RS | CRAM_RL | CRAM_BF) + +#define CRAM_SEQ (CRAM_CIGAR | CRAM_BA | CRAM_QS | CRAM_BS | \ + CRAM_RL | CRAM_AP | CRAM_BB | CRAM_QQ) + +/* BF bitfields */ +/* Corrected in 1.1. Use bam_flag_swap[bf] and BAM_* macros for 1.0 & 1.1 */ +#define CRAM_FPAIRED 256 +#define CRAM_FPROPER_PAIR 128 +#define CRAM_FUNMAP 64 +#define CRAM_FREVERSE 32 +#define CRAM_FREAD1 16 +#define CRAM_FREAD2 8 +#define CRAM_FSECONDARY 4 +#define CRAM_FQCFAIL 2 +#define CRAM_FDUP 1 + +#define DS_aux_S "\001" +#define DS_aux_OQ_S "\002" +#define DS_aux_BQ_S "\003" +#define DS_aux_BD_S "\004" +#define DS_aux_BI_S "\005" +#define DS_aux_FZ_S "\006" +#define DS_aux_oq_S "\007" +#define DS_aux_os_S "\010" +#define DS_aux_oz_S "\011" + +#define CRAM_M_REVERSE 1 +#define CRAM_M_UNMAP 2 + + +/* CF bitfields */ +#define CRAM_FLAG_PRESERVE_QUAL_SCORES (1<<0) +#define CRAM_FLAG_DETACHED (1<<1) +#define CRAM_FLAG_MATE_DOWNSTREAM (1<<2) + +#ifdef __cplusplus +} +#endif + +#endif /* _CRAM_STRUCTS_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/files.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,76 @@ +/* +Copyright (c) 1994, 1996-1997, 2000, 2003 MEDICAL RESEARCH COUNCIL +All rights reserved + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1 Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2 Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3 Neither the name of the MEDICAL RESEARCH COUNCIL, THE LABORATORY OF +MOLECULAR BIOLOGY nor the names of its contributors may be used to endorse or +promote products derived from this software without specific prior written +permission. + +THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR +ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES +(INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; +LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON +ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT +(INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS +SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + */ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include "cram/misc.h" + +#include <sys/types.h> +#include <sys/stat.h> +/* Alliant's Concentrix <sys/stat.h> is hugely deficient */ +/* Define things we require in this program */ +/* Methinks S_IFMT and S_IFDIR aren't defined in POSIX */ +#ifndef S_ISDIR +#define S_ISDIR(m) (((m)&S_IFMT) == S_IFDIR) +#endif /*!S_ISDIR*/ +#ifndef S_ISREG +#define S_ISREG(m) (((m)&S_IFMT) == S_IFREG) +#endif /*!S_ISREG*/ + +int is_directory(char * fn) +{ + struct stat buf; + if ( stat(fn,&buf) ) return 0; + return S_ISDIR(buf.st_mode); +} + +int is_file(char * fn) +{ + struct stat buf; + if ( stat(fn,&buf) ) return 0; + return S_ISREG(buf.st_mode); +} + +int file_exists(char * fn) +{ + struct stat buf; + return ( stat(fn,&buf) == 0); +} + +int file_size(char * fn) +{ + struct stat buf; + if ( stat(fn,&buf) != 0) return 0; + return buf.st_size; +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/mFILE.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,634 @@ +/* +Copyright (c) 2005-2006, 2008-2009, 2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdio.h> +#include <stdlib.h> +#include <errno.h> +#include <string.h> +#include <sys/types.h> +#include <sys/stat.h> +#include <fcntl.h> +#include <unistd.h> +#include <stdarg.h> + +#include "cram/os.h" +#include "cram/mFILE.h" +#include "cram/vlen.h" + +/* + * This file contains memory-based versions of the most commonly used + * (by io_lib) stdio functions. + * + * Actual file IO takes place either on opening or closing an mFILE. + * + * Coupled to this are a bunch of rather scary macros which can be obtained + * by including stdio_hack.h. It is recommended though that you use mFILE.h + * instead and replace fopen with mfopen (etc). This is more or less + * mandatory if you wish to use both FILE and mFILE structs in a single file. + */ + +static mFILE *m_channel[3]; /* stdin, stdout and stderr fakes */ + +/* + * Reads the entirety of fp into memory. If 'fn' exists it is the filename + * associated with fp. This will be used for more optimal reading (via a + * stat to identify the size and a single read). Otherwise we use successive + * reads until EOF. + * + * Returns a malloced buffer on success of length *size + * NULL on failure + */ +static char *mfload(FILE *fp, const char *fn, size_t *size, int binary) { + struct stat sb; + char *data = NULL; + size_t allocated = 0, used = 0; + int bufsize = 8192; + +#ifdef _WIN32 + if (binary) + _setmode(_fileno(fp), _O_BINARY); + else + _setmode(_fileno(fp), _O_TEXT); +#endif + + if (fn && -1 != stat(fn, &sb)) { + data = malloc(allocated = sb.st_size); + bufsize = sb.st_size; + } else { + fn = NULL; + } + + do { + size_t len; + if (used + bufsize > allocated) { + allocated += bufsize; + data = realloc(data, allocated); + } + len = fread(data + used, 1, allocated - used, fp); + if (len > 0) + used += len; + } while (!feof(fp) && (fn == NULL || used < sb.st_size)); + + *size = used; + + return data; +} + +/* + * Creates and returns m_channel[0]. + * We initialise this on the first attempted read, which then slurps in + * all of stdin until EOF is met. + */ +mFILE *mstdin(void) { + if (m_channel[0]) + return m_channel[0]; + + m_channel[0] = mfcreate(NULL, 0); + if (NULL == m_channel[0]) return NULL; + m_channel[0]->fp = stdin; + return m_channel[0]; +} + +static void init_mstdin(void) { + static int done_stdin = 0; + if (done_stdin) + return; + + m_channel[0]->data = mfload(stdin, NULL, &m_channel[0]->size, 1); + m_channel[0]->mode = MF_READ; + done_stdin = 1; +} + +/* + * Creates and returns m_channel[1]. This is the fake for stdout. It starts as + * an empty buffer which is physically written out only when mfflush or + * mfclose are called. + */ +mFILE *mstdout(void) { + if (m_channel[1]) + return m_channel[1]; + + m_channel[1] = mfcreate(NULL, 0); + if (NULL == m_channel[1]) return NULL; + m_channel[1]->fp = stdout; + m_channel[1]->mode = MF_WRITE; + return m_channel[1]; +} + +/* + * Stderr as an mFILE. + * The code handles stderr by returning m_channel[2], but also checking + * for stderr in fprintf (the common usage of it) to auto-flush. + */ +mFILE *mstderr(void) { + if (m_channel[2]) + return m_channel[2]; + + m_channel[2] = mfcreate(NULL, 0); + if (NULL == m_channel[2]) return NULL; + m_channel[2]->fp = stderr; + m_channel[2]->mode = MF_WRITE; + return m_channel[2]; +} + + +/* + * For creating existing mFILE pointers directly from memory buffers. + */ +mFILE *mfcreate(char *data, int size) { + mFILE *mf = (mFILE *)malloc(sizeof(*mf)); + if (NULL == mf) return NULL; + mf->fp = NULL; + mf->data = data; + mf->alloced = size; + mf->size = size; + mf->eof = 0; + mf->offset = 0; + mf->flush_pos = 0; + mf->mode = MF_READ | MF_WRITE; + return mf; +} + +/* + * Recreate an existing mFILE to house new data/size. + * It also rewinds the file. + */ +void mfrecreate(mFILE *mf, char *data, int size) { + if (mf->data) + free(mf->data); + mf->data = data; + mf->size = size; + mf->alloced = size; + mf->eof = 0; + mf->offset = 0; + mf->flush_pos = 0; +} + + +/* + * Creates a new mFILE to contain the contents of the FILE pointer. + * This mFILE is purely for in-memory operations and has no links to the + * original FILE* it came from. It also doesn't close the FILE pointer. + * Consider using mfreopen() is you need different behaviour. + * + * Returns mFILE * on success + * NULL on failure. + */ +mFILE *mfcreate_from(const char *path, const char *mode_str, FILE *fp) { + mFILE *mf; + + /* Open using mfreopen() */ + if (NULL == (mf = mfreopen(path, mode_str, fp))) + return NULL; + + /* Disassociate from the input stream */ + mf->fp = NULL; + + return mf; +} + +/* + * Converts a FILE * to an mFILE *. + * Use this for wrapper functions to turn external prototypes requring + * FILE * as an argument into internal code using mFILE *. + */ +mFILE *mfreopen(const char *path, const char *mode_str, FILE *fp) { + mFILE *mf; + int r = 0, w = 0, a = 0, b = 0, x = 0, mode = 0; + + /* Parse mode: + * r = read file contents (if truncated => don't read) + * w = write on close + * a = position at end of buffer + * x = position at same location as the original fp, don't seek on flush + */ + if (strchr(mode_str, 'r')) + r = 1, mode |= MF_READ; + if (strchr(mode_str, 'w')) + w = 1, mode |= MF_WRITE | MF_TRUNC; + if (strchr(mode_str, 'a')) + w = a = 1, mode |= MF_WRITE | MF_APPEND; + if (strchr(mode_str, 'b')) + b = 1, mode |= MF_BINARY; + if (strchr(mode_str, 'x')) + x = 1; + if (strchr(mode_str, '+')) { + w = 1, mode |= MF_READ | MF_WRITE; + if (a) + r = 1; + } + + if (r) { + mf = mfcreate(NULL, 0); + if (NULL == mf) return NULL; + if (!(mode & MF_TRUNC)) { + mf->data = mfload(fp, path, &mf->size, b); + mf->alloced = mf->size; + if (!a) + fseek(fp, 0, SEEK_SET); + } + } else if (w) { + /* Write - initialise the data structures */ + mf = mfcreate(NULL, 0); + if (NULL == mf) return NULL; + } else { + fprintf(stderr, "Must specify either r, w or a for mode\n"); + return NULL; + } + mf->fp = fp; + mf->mode = mode; + + if (x) { + mf->mode |= MF_MODEX; + } + + if (a) { + mf->flush_pos = mf->size; + fseek(fp, 0, SEEK_END); + } + + return mf; +} + +/* + * Opens a file. If we have read access (r or a+) then it loads the entire + * file into memory. If We have write access then the pathname is stored. + * We do not actually write until an mfclose, which then checks this pathname. + */ +mFILE *mfopen(const char *path, const char *mode) { + FILE *fp; + + if (NULL == (fp = fopen(path, mode))) + return NULL; + return mfreopen(path, mode, fp); +} + +/* + * Closes an mFILE. If the filename is known (implying write access) then this + * also writes the data to disk. + * + * Stdout is handled by calling mfflush which writes to stdout if appropriate. + */ +int mfclose(mFILE *mf) { + if (!mf) + return -1; + + mfflush(mf); + + if (mf->fp) + fclose(mf->fp); + + mfdestroy(mf); + + return 0; +} + +/* + * Closes the file pointer contained within the mFILE without destroying + * the in-memory data. + */ +int mfdetach(mFILE *mf) { + if (!mf) + return -1; + + mfflush(mf); + + if (mf->fp) { + fclose(mf->fp); + mf->fp = NULL; + } + + return 0; +} + +/* + * Destroys an mFILE structure but does not flush or close it + */ +int mfdestroy(mFILE *mf) { + if (!mf) + return -1; + + if (mf->data) + free(mf->data); + free(mf); + + return 0; +} + +/* + * Steals that data out of an mFILE. The mFILE itself will be closed. + * It is up to the caller to free the stolen buffer. If size_out is + * not NULL, mf->size will be stored in it. + * This is more-or-less the opposite of mfcreate(). + */ + +void *mfsteal(mFILE *mf, size_t *size_out) { + void *data; + + if (!mf) return NULL; + + data = mf->data; + + if (NULL != size_out) *size_out = mf->size; + + mfdetach(mf); + mf->data = NULL; + mfdestroy(mf); + + return data; +} + +/* + * Seek/tell functions. Nothing more than updating and reporting an + * in-memory index. NB we can seek on stdin or stdout even provided we + * haven't been flushing. + */ +int mfseek(mFILE *mf, long offset, int whence) { + switch (whence) { + case SEEK_SET: + mf->offset = offset; + break; + case SEEK_CUR: + mf->offset += offset; + break; + case SEEK_END: + mf->offset = mf->size + offset; + break; + default: + errno = EINVAL; + return -1; + } + + mf->eof = 0; + return 0; +} + +long mftell(mFILE *mf) { + return mf->offset; +} + +void mrewind(mFILE *mf) { + mf->offset = 0; + mf->eof = 0; +} + +/* + * mftruncate is not directly a translation of ftruncate as the latter + * takes a file descriptor instead of a FILE *. It performs the analogous + * role though. + * + * If offset is -1 then the file is truncated to be the current file + * offset. + */ +void mftruncate(mFILE *mf, long offset) { + mf->size = offset != -1 ? offset : mf->offset; + if (mf->offset > mf->size) + mf->offset = mf->size; +} + +int mfeof(mFILE *mf) { + return mf->eof; +} + +/* + * mFILE read/write functions. Basically these turn fread/fwrite syntax + * into memcpy statements, with appropriate memory handling for writing. + */ +size_t mfread(void *ptr, size_t size, size_t nmemb, mFILE *mf) { + size_t len; + char *cptr = (char *)ptr; + + if (mf == m_channel[0]) init_mstdin(); + + if (mf->size <= mf->offset) + return 0; + + len = size * nmemb <= mf->size - mf->offset + ? size * nmemb + : mf->size - mf->offset; + if (!size) + return 0; + + memcpy(cptr, &mf->data[mf->offset], len); + mf->offset += len; + + if (len != size * nmemb) { + mf->eof = 1; + } + + return len / size; +} + +size_t mfwrite(void *ptr, size_t size, size_t nmemb, mFILE *mf) { + if (!(mf->mode & MF_WRITE)) + return 0; + + /* Append mode => forced all writes to end of file */ + if (mf->mode & MF_APPEND) + mf->offset = mf->size; + + /* Make sure we have enough room */ + while (size * nmemb + mf->offset > mf->alloced) { + size_t new_alloced = mf->alloced ? mf->alloced * 2 : 1024; + void * new_data = realloc(mf->data, new_alloced); + if (NULL == new_data) return 0; + mf->alloced = new_alloced; + mf->data = new_data; + } + + /* Record where we need to reflush from */ + if (mf->offset < mf->flush_pos) + mf->flush_pos = mf->offset; + + /* Copy the data over */ + memcpy(&mf->data[mf->offset], ptr, size * nmemb); + mf->offset += size * nmemb; + if (mf->size < mf->offset) + mf->size = mf->offset; + + return nmemb; +} + +int mfgetc(mFILE *mf) { + if (mf == m_channel[0]) init_mstdin(); + if (mf->offset < mf->size) { + return (unsigned char)mf->data[mf->offset++]; + } + + mf->eof = 1; + return -1; +} + +int mungetc(int c, mFILE *mf) { + if (mf->offset > 0) { + mf->data[--mf->offset] = c; + return c; + } + + mf->eof = 1; + return -1; +} + +char *mfgets(char *s, int size, mFILE *mf) { + int i; + + if (mf == m_channel[0]) init_mstdin(); + *s = 0; + for (i = 0; i < size-1;) { + if (mf->offset < mf->size) { + s[i] = mf->data[mf->offset++]; + if (s[i++] == '\n') + break; + } else { + mf->eof = 1; + break; + } + } + + s[i] = 0; + return i ? s : NULL; +} + +/* + * Flushes an mFILE. If this is a real open of a file in write mode then + * mFILE->fp will be set. We then write out any new data in mFILE since the + * last flush. We cannot tell what may have been modified as we don't keep + * track of that, so we typically rewrite out the entire file contents between + * the last flush_pos and the end of file. + * + * For stderr/stdout we also reset the offsets so we cannot modify things + * we've already output. + */ +int mfflush(mFILE *mf) { + if (!mf->fp) + return 0; + + /* FIXME: only do this when opened in write mode */ + if (mf == m_channel[1] || mf == m_channel[2]) { + if (mf->flush_pos < mf->size) { + size_t bytes = mf->size - mf->flush_pos; + if (fwrite(mf->data + mf->flush_pos, 1, bytes, mf->fp) < bytes) + return -1; + if (0 != fflush(mf->fp)) + return -1; + } + + /* Stdout & stderr are non-seekable streams so throw away the data */ + mf->offset = mf->size = mf->flush_pos = 0; + } + + /* only flush when opened in write mode */ + if (mf->mode & MF_WRITE) { + if (mf->flush_pos < mf->size) { + size_t bytes = mf->size - mf->flush_pos; + if (!(mf->mode & MF_MODEX)) { + fseek(mf->fp, mf->flush_pos, SEEK_SET); + } + if (fwrite(mf->data + mf->flush_pos, 1, bytes, mf->fp) < bytes) + return -1; + if (0 != fflush(mf->fp)) + return -1; + } + if (ftell(mf->fp) != -1 && + ftruncate(fileno(mf->fp), ftell(mf->fp)) == -1) + return -1; + mf->flush_pos = mf->size; + } + + return 0; +} + +/* + * A wrapper around vsprintf() to write to an mFILE. This also uses vflen() to + * estimate how many additional bytes of storage will be required for the + * vsprintf to work. + */ +int mfprintf(mFILE *mf, char *fmt, ...) { + int ret; + size_t est_length; + va_list args; + + va_start(args, fmt); + est_length = vflen(fmt, args); + va_end(args); + while (est_length + mf->offset > mf->alloced) { + size_t new_alloced = mf->alloced ? mf->alloced * 2 : 1024; + void * new_data = realloc(mf->data, new_alloced); + if (NULL == new_data) return -1; + mf->alloced = new_alloced; + mf->data = new_data; + } + + va_start(args, fmt); + ret = vsprintf(&mf->data[mf->offset], fmt, args); + va_end(args); + + if (ret > 0) { + mf->offset += ret; + if (mf->size < mf->offset) + mf->size = mf->offset; + } + + if (mf->fp == stderr) { + /* Auto-flush for stderr */ + if (0 != mfflush(mf)) return -1; + } + + return ret; +} + +/* + * Converts an mFILE from binary to ascii mode by replacing all + * cr-nl with nl. + * + * Primarily used on windows when we've uncompressed a binary file which + * happens to be a text file (eg Experiment File). Previously we would have + * seeked back to the start and used _setmode(fileno(fp), _O_TEXT). + * + * Side effect: resets offset and flush_pos back to the start. + */ +void mfascii(mFILE *mf) { + size_t p1, p2; + + for (p1 = p2 = 1; p1 < mf->size; p1++, p2++) { + if (mf->data[p1] == '\n' && mf->data[p1-1] == '\r') { + p2--; /* delete the \r */ + } + mf->data[p2] = mf->data[p1]; + } + mf->size = p2; + + mf->offset = mf->flush_pos = 0; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/mFILE.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,88 @@ +/* +Copyright (c) 2005-2006, 2008-2009 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _MFILE_H_ +#define _MFILE_H_ + +#include <stdio.h> + +#ifdef __cplusplus +extern "C" { +#endif + +typedef struct { + FILE *fp; + char *data; + size_t alloced; + int eof; + int mode; /* open mode in MF_?? define bit pattern */ + size_t size; + size_t offset; + size_t flush_pos; +} mFILE; + +#define MF_READ 1 +#define MF_WRITE 2 +#define MF_APPEND 4 +#define MF_BINARY 8 +#define MF_TRUNC 16 +#define MF_MODEX 32 + +mFILE *mfreopen(const char *path, const char *mode, FILE *fp); +mFILE *mfopen(const char *path, const char *mode); +int mfdetach(mFILE *mf); +int mfclose(mFILE *mf); +int mfdestroy(mFILE *mf); +int mfseek(mFILE *mf, long offset, int whence); +long mftell(mFILE *mf); +void mrewind(mFILE *mf); +void mftruncate(mFILE *mf, long offset); +int mfeof(mFILE *mf); +size_t mfread(void *ptr, size_t size, size_t nmemb, mFILE *mf); +size_t mfwrite(void *ptr, size_t size, size_t nmemb, mFILE *mf); +int mfgetc(mFILE *mf); +int mungetc(int c, mFILE *mf); +mFILE *mfcreate(char *data, int size); +mFILE *mfcreate_from(const char *path, const char *mode_str, FILE *fp); +void mfrecreate(mFILE *mf, char *data, int size); +void *mfsteal(mFILE *mf, size_t *size_out); +char *mfgets(char *s, int size, mFILE *mf); +int mfflush(mFILE *mf); +int mfprintf(mFILE *mf, char *fmt, ...); +mFILE *mstdin(void); +mFILE *mstdout(void); +mFILE *mstderr(void); +void mfascii(mFILE *mf); + +#ifdef __cplusplus +} +#endif + +#endif /* _MFILE_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/md5.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,295 @@ +/* + * This is an OpenSSL-compatible implementation of the RSA Data Security, Inc. + * MD5 Message-Digest Algorithm (RFC 1321). + * + * Homepage: + * http://openwall.info/wiki/people/solar/software/public-domain-source-code/md5 + * + * Author: + * Alexander Peslyak, better known as Solar Designer <solar at openwall.com> + * + * This software was written by Alexander Peslyak in 2001. No copyright is + * claimed, and the software is hereby placed in the public domain. + * In case this attempt to disclaim copyright and place the software in the + * public domain is deemed null and void, then the software is + * Copyright (c) 2001 Alexander Peslyak and it is hereby released to the + * general public under the following terms: + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted. + * + * There's ABSOLUTELY NO WARRANTY, express or implied. + * + * (This is a heavily cut-down "BSD license".) + * + * This differs from Colin Plumb's older public domain implementation in that + * no exactly 32-bit integer data type is required (any 32-bit or wider + * unsigned integer data type will do), there's no compile-time endianness + * configuration, and the function prototypes match OpenSSL's. No code from + * Colin Plumb's implementation has been reused; this comment merely compares + * the properties of the two independent implementations. + * + * The primary goals of this implementation are portability and ease of use. + * It is meant to be fast, but not as fast as possible. Some known + * optimizations are not included to reduce source code size and avoid + * compile-time configuration. + */ + +#ifndef HAVE_OPENSSL + +#include <string.h> + +#include "md5.h" + +/* + * The basic MD5 functions. + * + * F and G are optimized compared to their RFC 1321 definitions for + * architectures that lack an AND-NOT instruction, just like in Colin Plumb's + * implementation. + */ +#define F(x, y, z) ((z) ^ ((x) & ((y) ^ (z)))) +#define G(x, y, z) ((y) ^ ((z) & ((x) ^ (y)))) +#define H(x, y, z) ((x) ^ (y) ^ (z)) +#define I(x, y, z) ((y) ^ ((x) | ~(z))) + +/* + * The MD5 transformation for all four rounds. + */ +#define STEP(f, a, b, c, d, x, t, s) \ + (a) += f((b), (c), (d)) + (x) + (t); \ + (a) = (((a) << (s)) | (((a) & 0xffffffff) >> (32 - (s)))); \ + (a) += (b); + +/* + * SET reads 4 input bytes in little-endian byte order and stores them + * in a properly aligned word in host byte order. + * + * The check for little-endian architectures that tolerate unaligned + * memory accesses is just an optimization. Nothing will break if it + * doesn't work. + */ +#if defined(__i386__) || defined(__x86_64__) || defined(__vax__) +#define SET(n) \ + (*(MD5_u32plus *)&ptr[(n) * 4]) +#define GET(n) \ + SET(n) +#else +#define SET(n) \ + (ctx->block[(n)] = \ + (MD5_u32plus)ptr[(n) * 4] | \ + ((MD5_u32plus)ptr[(n) * 4 + 1] << 8) | \ + ((MD5_u32plus)ptr[(n) * 4 + 2] << 16) | \ + ((MD5_u32plus)ptr[(n) * 4 + 3] << 24)) +#define GET(n) \ + (ctx->block[(n)]) +#endif + +/* + * This processes one or more 64-byte data blocks, but does NOT update + * the bit counters. There are no alignment requirements. + */ +static void *body(MD5_CTX *ctx, void *data, unsigned long size) +{ + unsigned char *ptr; + MD5_u32plus a, b, c, d; + MD5_u32plus saved_a, saved_b, saved_c, saved_d; + + ptr = data; + + a = ctx->a; + b = ctx->b; + c = ctx->c; + d = ctx->d; + + do { + saved_a = a; + saved_b = b; + saved_c = c; + saved_d = d; + +/* Round 1 */ + STEP(F, a, b, c, d, SET(0), 0xd76aa478, 7) + STEP(F, d, a, b, c, SET(1), 0xe8c7b756, 12) + STEP(F, c, d, a, b, SET(2), 0x242070db, 17) + STEP(F, b, c, d, a, SET(3), 0xc1bdceee, 22) + STEP(F, a, b, c, d, SET(4), 0xf57c0faf, 7) + STEP(F, d, a, b, c, SET(5), 0x4787c62a, 12) + STEP(F, c, d, a, b, SET(6), 0xa8304613, 17) + STEP(F, b, c, d, a, SET(7), 0xfd469501, 22) + STEP(F, a, b, c, d, SET(8), 0x698098d8, 7) + STEP(F, d, a, b, c, SET(9), 0x8b44f7af, 12) + STEP(F, c, d, a, b, SET(10), 0xffff5bb1, 17) + STEP(F, b, c, d, a, SET(11), 0x895cd7be, 22) + STEP(F, a, b, c, d, SET(12), 0x6b901122, 7) + STEP(F, d, a, b, c, SET(13), 0xfd987193, 12) + STEP(F, c, d, a, b, SET(14), 0xa679438e, 17) + STEP(F, b, c, d, a, SET(15), 0x49b40821, 22) + +/* Round 2 */ + STEP(G, a, b, c, d, GET(1), 0xf61e2562, 5) + STEP(G, d, a, b, c, GET(6), 0xc040b340, 9) + STEP(G, c, d, a, b, GET(11), 0x265e5a51, 14) + STEP(G, b, c, d, a, GET(0), 0xe9b6c7aa, 20) + STEP(G, a, b, c, d, GET(5), 0xd62f105d, 5) + STEP(G, d, a, b, c, GET(10), 0x02441453, 9) + STEP(G, c, d, a, b, GET(15), 0xd8a1e681, 14) + STEP(G, b, c, d, a, GET(4), 0xe7d3fbc8, 20) + STEP(G, a, b, c, d, GET(9), 0x21e1cde6, 5) + STEP(G, d, a, b, c, GET(14), 0xc33707d6, 9) + STEP(G, c, d, a, b, GET(3), 0xf4d50d87, 14) + STEP(G, b, c, d, a, GET(8), 0x455a14ed, 20) + STEP(G, a, b, c, d, GET(13), 0xa9e3e905, 5) + STEP(G, d, a, b, c, GET(2), 0xfcefa3f8, 9) + STEP(G, c, d, a, b, GET(7), 0x676f02d9, 14) + STEP(G, b, c, d, a, GET(12), 0x8d2a4c8a, 20) + +/* Round 3 */ + STEP(H, a, b, c, d, GET(5), 0xfffa3942, 4) + STEP(H, d, a, b, c, GET(8), 0x8771f681, 11) + STEP(H, c, d, a, b, GET(11), 0x6d9d6122, 16) + STEP(H, b, c, d, a, GET(14), 0xfde5380c, 23) + STEP(H, a, b, c, d, GET(1), 0xa4beea44, 4) + STEP(H, d, a, b, c, GET(4), 0x4bdecfa9, 11) + STEP(H, c, d, a, b, GET(7), 0xf6bb4b60, 16) + STEP(H, b, c, d, a, GET(10), 0xbebfbc70, 23) + STEP(H, a, b, c, d, GET(13), 0x289b7ec6, 4) + STEP(H, d, a, b, c, GET(0), 0xeaa127fa, 11) + STEP(H, c, d, a, b, GET(3), 0xd4ef3085, 16) + STEP(H, b, c, d, a, GET(6), 0x04881d05, 23) + STEP(H, a, b, c, d, GET(9), 0xd9d4d039, 4) + STEP(H, d, a, b, c, GET(12), 0xe6db99e5, 11) + STEP(H, c, d, a, b, GET(15), 0x1fa27cf8, 16) + STEP(H, b, c, d, a, GET(2), 0xc4ac5665, 23) + +/* Round 4 */ + STEP(I, a, b, c, d, GET(0), 0xf4292244, 6) + STEP(I, d, a, b, c, GET(7), 0x432aff97, 10) + STEP(I, c, d, a, b, GET(14), 0xab9423a7, 15) + STEP(I, b, c, d, a, GET(5), 0xfc93a039, 21) + STEP(I, a, b, c, d, GET(12), 0x655b59c3, 6) + STEP(I, d, a, b, c, GET(3), 0x8f0ccc92, 10) + STEP(I, c, d, a, b, GET(10), 0xffeff47d, 15) + STEP(I, b, c, d, a, GET(1), 0x85845dd1, 21) + STEP(I, a, b, c, d, GET(8), 0x6fa87e4f, 6) + STEP(I, d, a, b, c, GET(15), 0xfe2ce6e0, 10) + STEP(I, c, d, a, b, GET(6), 0xa3014314, 15) + STEP(I, b, c, d, a, GET(13), 0x4e0811a1, 21) + STEP(I, a, b, c, d, GET(4), 0xf7537e82, 6) + STEP(I, d, a, b, c, GET(11), 0xbd3af235, 10) + STEP(I, c, d, a, b, GET(2), 0x2ad7d2bb, 15) + STEP(I, b, c, d, a, GET(9), 0xeb86d391, 21) + + a += saved_a; + b += saved_b; + c += saved_c; + d += saved_d; + + ptr += 64; + } while (size -= 64); + + ctx->a = a; + ctx->b = b; + ctx->c = c; + ctx->d = d; + + return ptr; +} + +void MD5_Init(MD5_CTX *ctx) +{ + ctx->a = 0x67452301; + ctx->b = 0xefcdab89; + ctx->c = 0x98badcfe; + ctx->d = 0x10325476; + + ctx->lo = 0; + ctx->hi = 0; +} + +void MD5_Update(MD5_CTX *ctx, void *data, unsigned long size) +{ + MD5_u32plus saved_lo; + unsigned long used, free; + + saved_lo = ctx->lo; + if ((ctx->lo = (saved_lo + size) & 0x1fffffff) < saved_lo) + ctx->hi++; + ctx->hi += size >> 29; + + used = saved_lo & 0x3f; + + if (used) { + free = 64 - used; + + if (size < free) { + memcpy(&ctx->buffer[used], data, size); + return; + } + + memcpy(&ctx->buffer[used], data, free); + data = (unsigned char *)data + free; + size -= free; + body(ctx, ctx->buffer, 64); + } + + if (size >= 64) { + data = body(ctx, data, size & ~(unsigned long)0x3f); + size &= 0x3f; + } + + memcpy(ctx->buffer, data, size); +} + +void MD5_Final(unsigned char *result, MD5_CTX *ctx) +{ + unsigned long used, free; + + used = ctx->lo & 0x3f; + + ctx->buffer[used++] = 0x80; + + free = 64 - used; + + if (free < 8) { + memset(&ctx->buffer[used], 0, free); + body(ctx, ctx->buffer, 64); + used = 0; + free = 64; + } + + memset(&ctx->buffer[used], 0, free - 8); + + ctx->lo <<= 3; + ctx->buffer[56] = ctx->lo; + ctx->buffer[57] = ctx->lo >> 8; + ctx->buffer[58] = ctx->lo >> 16; + ctx->buffer[59] = ctx->lo >> 24; + ctx->buffer[60] = ctx->hi; + ctx->buffer[61] = ctx->hi >> 8; + ctx->buffer[62] = ctx->hi >> 16; + ctx->buffer[63] = ctx->hi >> 24; + + body(ctx, ctx->buffer, 64); + + result[0] = ctx->a; + result[1] = ctx->a >> 8; + result[2] = ctx->a >> 16; + result[3] = ctx->a >> 24; + result[4] = ctx->b; + result[5] = ctx->b >> 8; + result[6] = ctx->b >> 16; + result[7] = ctx->b >> 24; + result[8] = ctx->c; + result[9] = ctx->c >> 8; + result[10] = ctx->c >> 16; + result[11] = ctx->c >> 24; + result[12] = ctx->d; + result[13] = ctx->d >> 8; + result[14] = ctx->d >> 16; + result[15] = ctx->d >> 24; + + memset(ctx, 0, sizeof(*ctx)); +} + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/md5.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,54 @@ +#ifdef __cplusplus +extern "C" { +#endif + +/* + * This is an OpenSSL-compatible implementation of the RSA Data Security, Inc. + * MD5 Message-Digest Algorithm (RFC 1321). + * + * Homepage: + * http://openwall.info/wiki/people/solar/software/public-domain-source-code/md5 + * + * Author: + * Alexander Peslyak, better known as Solar Designer <solar at openwall.com> + * + * This software was written by Alexander Peslyak in 2001. No copyright is + * claimed, and the software is hereby placed in the public domain. + * In case this attempt to disclaim copyright and place the software in the + * public domain is deemed null and void, then the software is + * Copyright (c) 2001 Alexander Peslyak and it is hereby released to the + * general public under the following terms: + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted. + * + * There's ABSOLUTELY NO WARRANTY, express or implied. + * + * See md5.c for more information. + */ + +#ifdef HAVE_OPENSSL +#include <openssl/md5.h> +#elif !defined(_MD5_H) +#define _MD5_H + +/* Any 32-bit or wider unsigned integer data type will do */ +typedef unsigned int MD5_u32plus; + +typedef struct { + MD5_u32plus lo, hi; + MD5_u32plus a, b, c, d; + unsigned char buffer[64]; + MD5_u32plus block[16]; +} MD5_CTX; + +extern void MD5_Init(MD5_CTX *ctx); +extern void MD5_Update(MD5_CTX *ctx, void *data, unsigned long size); +extern void MD5_Final(unsigned char *result, MD5_CTX *ctx); + +#endif + +#ifdef __cplusplus +} +#endif +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/misc.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,110 @@ +/* +Copyright (c) 1994-1997, 2001-2002 MEDICAL RESEARCH COUNCIL +All rights reserved + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1 Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2 Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3 Neither the name of the MEDICAL RESEARCH COUNCIL, THE LABORATORY OF +MOLECULAR BIOLOGY nor the names of its contributors may be used to endorse or +promote products derived from this software without specific prior written +permission. + +THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR +ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES +(INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; +LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON +ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT +(INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS +SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + */ + +/* +Copyright (c) 2003-2013 Genome Research Ltd. + +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _misc_h +#define _misc_h + +#include "cram/os.h" + +#include <stdio.h> +#include <stdarg.h> /* varargs needed for v*printf() prototypes */ +#include <sys/types.h> + +#ifdef __cplusplus +extern "C" { +#endif + +/* + * This informs gcc that crash() doesn't return, so it doesn't need to + * concern itself that code paths going via crash could mean some variables + * being undefined and then issuing uninitialised variable warnings. + * This particularly affected convert. + */ +#ifdef __GNUC__ +# define __NORETURN__ __attribute__ ((__noreturn__)) +#else +# define __NORETURN__ +#endif + +/* + * Used for printf style argument checking. We can request a function such + * as vTcl_SetResult does argument checking, avoiding bugs with using + * %d and passing in a 64-bit record. + */ +#ifdef __GNUC__ +# define __PRINTF_FORMAT__(a,b) __attribute__ ((format (printf, a, b))) +#else +# define __PRINTF_FORMAT__(a,b) +#endif + +extern int is_directory(char * fn); +extern int is_file(char * fn); +extern int file_size(char * fn); + +#define MIN(A,B) ( ( (A) < (B) ) ? (A) : (B) ) +#define MAX(A,B) ( ( (A) > (B) ) ? (A) : (B) ) + +#ifdef __cplusplus +} +#endif + +#endif /*_misc_h*/
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/open_trace_file.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,351 @@ +/* +Author: James Bonfield + +Copyright (c) 2000-2001 MEDICAL RESEARCH COUNCIL +All rights reserved + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the name of the MEDICAL RESEARCH COUNCIL, THE LABORATORY OF +MOLECULAR BIOLOGY nor the names of its contributors may be used to endorse or +promote products derived from this software without specific prior written +permission. + +THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR +ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES +(INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; +LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON +ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT +(INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS +SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* +Copyright (c) 2008, 2009, 2013, 2014 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#include <stdlib.h> +#include <stdio.h> +#include <string.h> +#include <unistd.h> +#include <ctype.h> +#include <limits.h> +#include <sys/types.h> +#include <sys/stat.h> +#include "cram/os.h" +#ifndef PATH_MAX +# define PATH_MAX 1024 +#endif + +#include "cram/open_trace_file.h" +#include "cram/misc.h" +#include "htslib/hfile.h" + +/* + * Tokenises the search path splitting on colons (unix) or semicolons + * (windows). + * We also explicitly add a "./" to the end of the search path + * + * Returns: A new search path with items separated by nul chars. Two nul + * chars in a row represent the end of the tokenised path. + * Returns NULL for a failure. + * + * The returned data has been malloced. It is up to the caller to free this + * memory. + */ +char *tokenise_search_path(char *searchpath) { + char *newsearch; + unsigned int i, j; + size_t len; +#ifdef _WIN32 + char path_sep = ';'; +#else + char path_sep = ':'; +#endif + + if (!searchpath) + searchpath=""; + + newsearch = (char *)malloc((len = strlen(searchpath))+5); + if (!newsearch) + return NULL; + + for (i = 0, j = 0; i < len; i++) { + /* "::" => ":". Used for escaping colons in http://foo */ + if (i < len-1 && searchpath[i] == ':' && searchpath[i+1] == ':') { + newsearch[j++] = ':'; + i++; + continue; + } + + /* Handle http:// and ftp:// too without :: */ + if (path_sep == ':') { + if ((i == 0 || (i > 0 && searchpath[i-1] == ':')) && + (!strncmp(&searchpath[i], "http:", 5) || + !strncmp(&searchpath[i], "ftp:", 4) || + !strncmp(&searchpath[i], "|http:", 6) || + !strncmp(&searchpath[i], "|ftp:", 5) || + !strncmp(&searchpath[i], "URL=http:", 9) || + !strncmp(&searchpath[i], "URL=ftp:", 8))) { + do { + newsearch[j++] = searchpath[i]; + } while (i<len && searchpath[i++] != ':'); + if (searchpath[i] == ':') + i++; + if (searchpath[i]=='/') + newsearch[j++] = searchpath[i++]; + if (searchpath[i]=='/') + newsearch[j++] = searchpath[i++]; + // Look for host:port + do { + newsearch[j++] = searchpath[i++]; + } while (i<len && searchpath[i] != ':' && searchpath[i] != '/'); + newsearch[j++] = searchpath[i++]; + if (searchpath[i] == ':') + i++; + } + } + + if (searchpath[i] == path_sep) { + /* Skip blank path components */ + if (j && newsearch[j-1] != 0) + newsearch[j++] = 0; + } else { + newsearch[j++] = searchpath[i]; + } + } + + if (j) + newsearch[j++] = 0; + newsearch[j++] = '.'; + newsearch[j++] = '/'; + newsearch[j++] = 0; + newsearch[j++] = 0; + + return newsearch; +} + +mFILE *find_file_url(char *file, char *url) { + char buf[8192], *cp; + mFILE *mf = NULL; + int maxlen = 8190 - strlen(file), len; + hFILE *hf; + + /* Expand %s for the trace name */ + for (cp = buf; *url && cp - buf < maxlen; url++) { + if (*url == '%' && *(url+1) == 's') { + url++; + cp += strlen(strcpy(cp, file)); + } else { + *cp++ = *url; + } + } + *cp++ = 0; + + if (!(hf = hopen(buf, "r"))) + return NULL; + + if (NULL == (mf = mfcreate(NULL, 0))) + return NULL; + while ((len = hread(hf, buf, 8192)) > 0) { + if (mfwrite(buf, len, 1, mf) <= 0) { + hclose_abruptly(hf); + mfdestroy(mf); + return NULL; + } + } + if (hclose(hf) < 0) { + mfdestroy(mf); + return NULL; + } + + mrewind(mf); + return mf; +} + +/* + * Searches for file in the directory 'dirname'. If it finds it, it opens + * it. This also searches for compressed versions of the file in dirname + * too. + * + * Returns mFILE pointer if found + * NULL if not + */ +static mFILE *find_file_dir(char *file, char *dirname) { + char path[PATH_MAX+1]; + size_t len = strlen(dirname); + char *cp; + + if (dirname[len-1] == '/') + len--; + + /* Special case for "./" or absolute filenames */ + if (*file == '/' || (len==1 && *dirname == '.')) { + sprintf(path, "%s", file); + } else { + /* Handle %[0-9]*s expansions, if required */ + char *path_end = path; + *path = 0; + while ((cp = strchr(dirname, '%'))) { + char *endp; + long l = strtol(cp+1, &endp, 10); + if (*endp != 's') { + strncpy(path_end, dirname, (endp+1)-dirname); + path_end += (endp+1)-dirname; + dirname = endp+1; + continue; + } + + strncpy(path_end, dirname, cp-dirname); + path_end += cp-dirname; + if (l) { + strncpy(path_end, file, l); + path_end += MIN(strlen(file), l); + file += MIN(strlen(file), l); + } else { + strcpy(path_end, file); + path_end += strlen(file); + file += strlen(file); + } + len -= (endp+1) - dirname; + dirname = endp+1; + } + strncpy(path_end, dirname, len); + path_end += MIN(strlen(dirname), len); + *path_end = 0; + if (*file) { + *path_end++ = '/'; + strcpy(path_end, file); + } + + //fprintf(stderr, "*PATH=\"%s\"\n", path); + } + + if (is_file(path)) { + return mfopen(path, "rb"); + } + + return NULL; +} + +/* + * ------------------------------------------------------------------------ + * Public functions below. + */ + +/* + * Opens a trace file named 'file'. This is initially looked for as a + * pathname relative to a file named "relative_to". This may (for + * example) be the name of an experiment file referencing the trace + * file. In this case by passing relative_to as the experiment file + * filename the trace file will be picked up in the same directory as + * the experiment file. Relative_to may be supplied as NULL. + * + * 'file' is looked for at relative_to, then the current directory, and then + * all of the locations listed in 'path' (which is a colon separated list). + * If 'path' is NULL it uses the RAWDATA environment variable instead. + * + * Returns a mFILE pointer when found. + * NULL otherwise. + */ +mFILE *open_path_mfile(char *file, char *path, char *relative_to) { + char *newsearch; + char *ele; + mFILE *fp; + + /* Use path first */ + if (!path) + path = getenv("RAWDATA"); + if (NULL == (newsearch = tokenise_search_path(path))) + return NULL; + + /* + * Step through the search path testing out each component. + * We now look through each path element treating some prefixes as + * special, otherwise we treat the element as a directory. + */ + for (ele = newsearch; *ele; ele += strlen(ele)+1) { + char *ele2; + + /* + * '|' prefixing a path component indicates that we do not + * wish to perform the compression extension searching in that + * location. + * + * NB: this has been removed from the htslib implementation. + */ + if (*ele == '|') { + ele2 = ele+1; + } else { + ele2 = ele; + } + + if (0 == strncmp(ele2, "URL=", 4)) { + if ((fp = find_file_url(file, ele2+4))) { + free(newsearch); + return fp; + } + } else if (!strncmp(ele2, "http:", 5) || + !strncmp(ele2, "ftp:", 4)) { + if ((fp = find_file_url(file, ele2))) { + free(newsearch); + return fp; + } + } else if ((fp = find_file_dir(file, ele2))) { + free(newsearch); + return fp; + } + } + + free(newsearch); + + /* Look in the same location as the incoming 'relative_to' filename */ + if (relative_to) { + char *cp; + char relative_path[PATH_MAX+1]; + strcpy(relative_path, relative_to); + if ((cp = strrchr(relative_path, '/'))) + *cp = 0; + if ((fp = find_file_dir(file, relative_path))) + return fp; + } + + return NULL; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/open_trace_file.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,115 @@ +/* +Author: James Bonfield + +Copyright (c) 2000-2001 MEDICAL RESEARCH COUNCIL +All rights reserved + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + . Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + . Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + . Neither the name of the MEDICAL RESEARCH COUNCIL, THE LABORATORY OF +MOLECULAR BIOLOGY nor the names of its contributors may be used to endorse or +promote products derived from this software without specific prior written +permission. + +THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR +ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES +(INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; +LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON +ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT +(INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS +SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* +Copyright (c) 2008, 2009, 2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _OPEN_TRACE_FILE_H_ +#define _OPEN_TRACE_FILE_H_ + +#include "cram/mFILE.h" + +#ifdef __cplusplus +extern "C" { +#endif + +/* + * Tokenises the search path splitting on colons (unix) or semicolons + * (windows). + * We also explicitly add a "./" to the end of the search path + * + * Returns: A new search path with items separated by nul chars. Two nul + * chars in a row represent the end of the tokenised path. + * Returns NULL for a failure. + * + * The returned data has been malloced. It is up to the caller to free this + * memory. + */ +char *tokenise_search_path(char *searchpath); + +/* + * Opens a trace file named 'file'. This is initially looked for as a + * pathname relative to a file named "relative_to". This may (for + * example) be the name of an experiment file referencing the trace + * file. In this case by passing relative_to as the experiment file + * filename the trace file will be picked up in the same directory as + * the experiment file. Relative_to may be supplied as NULL. + * + * 'file' is looked for at relative_to, then the current directory, and then + * all of the locations listed in 'path' (which is a colon separated list). + * If 'path' is NULL it uses the RAWDATA environment variable instead. + * + * Returns a mFILE pointer when found. + * NULL otherwise. + */ +mFILE *open_path_mfile(char *file, char *path, char *relative_to); + +/* + * Returns a mFILE containing the entire contents of the url; + * NULL on failure. + */ +mFILE *find_file_url(char *file, char *url); + + +#ifdef __cplusplus +} +#endif + +#endif /* _OPEN_TRACE_FILE_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/os.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,308 @@ +/* +Copyright (c) 1993, 1995-2002 MEDICAL RESEARCH COUNCIL +All rights reserved + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1 Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2 Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3 Neither the name of the MEDICAL RESEARCH COUNCIL, THE LABORATORY OF +MOLECULAR BIOLOGY nor the names of its contributors may be used to endorse or +promote products derived from this software without specific prior written +permission. + +THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR +ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES +(INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; +LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON +ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT +(INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS +SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* +Copyright (c) 2004, 2006, 2009-2011, 2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* + * File: os.h + * + * Author: + * MRC Laboratory of Molecular Biology + * Hills Road + * Cambridge CB2 2QH + * United Kingdom + * + * Description: operating system specific type definitions + * + */ + +#ifndef _OS_H_ +#define _OS_H_ + +#include <limits.h> +#include <inttypes.h> + +#ifdef __cplusplus +extern "C" { +#endif + +/*----------------------------------------------------------------------------- + * Detection of endianness. The main part of this is done in autoconf, but + * for the case of MacOS FAT binaries we fall back on auto-sensing based on + * processor type too. + */ + +/* Set by autoconf */ +#define SP_LITTLE_ENDIAN + +/* Mac FAT binaries or unknown. Auto detect based on CPU type */ +#if !defined(SP_BIG_ENDIAN) && !defined(SP_LITTLE_ENDIAN) + +/* + * x86 equivalents + */ +#if defined(__i386__) || defined(__i386) || defined(__amd64__) || defined(__amd64) || defined(__x86_64__) || defined(__x86_64) || defined(__i686__) || defined(__i686) +# if defined(SP_BIG_ENDIAN) +# undef SP_BIG_ENDIAN +# endif +# define SP_LITTLE_ENDIAN +#endif + +/* + * DEC Alpha + */ +#if defined(__alpha__) || defined(__alpha) +# if defined(SP_LITTLE_ENDIAN) +# undef SP_LITTLE_ENDIAN +# endif +# define SP_BIG_ENDIAN +#endif + +/* + * SUN Sparc + */ +#if defined(__sparc__) || defined(__sparc) +# if defined(SP_LITTLE_ENDIAN) +# undef SP_LITTLE_ENDIAN +# endif +# define SP_BIG_ENDIAN +#endif + +/* + * PowerPC + */ +#if defined(__ppc__) || defined(__ppc) +# if defined(SP_LITTLE_ENDIAN) +# undef SP_LITTLE_ENDIAN +# endif +# define SP_BIG_ENDIAN +#endif + +/* Some catch-alls */ +#if defined(__LITTLE_ENDIAN__) || defined(__LITTLEENDIAN__) +# define SP_LITTLE_ENDIAN +#endif + +#if defined(__BIG_ENDIAN__) || defined(__BIGENDIAN__) +# define SP_BIG_ENDIAN +#endif + +#if defined(SP_BIG_ENDIAN) && defined(SP_LITTLE_ENDIAN) +# error Both BIG and LITTLE endian defined. Fix os.h and/or Makefile +#endif + +#if !defined(SP_BIG_ENDIAN) && !defined(SP_LITTLE_ENDIAN) +# error Neither BIG nor LITTLE endian defined. Fix os.h and/or Makefile +#endif + +#endif + +/*----------------------------------------------------------------------------- + * Allow for unaligned memory access. This is used in BAM code as the packed + * structure has 4-byte cigar ints after the variable length name. + * + * Consider using AX_CHECK_ALIGNED_ACCESS_REQUIRED in autoconf. + */ +#if defined(__i386__) || defined(__i386) || defined(__amd64__) || defined(__amd64) || defined(__x86_64__) || defined(__x86_64) || defined(__i686__) || defined(__i686) +# define ALLOW_UAC +#endif + +/*----------------------------------------------------------------------------- + * Byte swapping macros + */ + +/* + * Our new swap runs at the same speed on Ultrix, but substantially faster + * (300% for swap_int4, ~50% for swap_int2) on an Alpha (due to the lack of + * decent 'char' support). + * + * They also have the ability to swap in situ (src == dst). Newer code now + * relies on this so don't change back! + */ +#define iswap_int8(x) \ + (((x & 0x00000000000000ffLL) << 56) + \ + ((x & 0x000000000000ff00LL) << 40) + \ + ((x & 0x0000000000ff0000LL) << 24) + \ + ((x & 0x00000000ff000000LL) << 8) + \ + ((x & 0x000000ff00000000LL) >> 8) + \ + ((x & 0x0000ff0000000000LL) >> 24) + \ + ((x & 0x00ff000000000000LL) >> 40) + \ + ((x & 0xff00000000000000LL) >> 56)) + +#define iswap_int4(x) \ + (((x & 0x000000ff) << 24) + \ + ((x & 0x0000ff00) << 8) + \ + ((x & 0x00ff0000) >> 8) + \ + ((x & 0xff000000) >> 24)) + +#define iswap_int2(x) \ + (((x & 0x00ff) << 8) + \ + ((x & 0xff00) >> 8)) + +/* + * Linux systems may use byteswap.h to get assembly versions of byte-swap + * on intel systems. This can be as trivial as the bswap opcode, which works + * out at over 2-times faster than iswap_int4 above. + */ +#if 0 +#if defined(__linux__) +# include <byteswap.h> +# undef iswap_int8 +# undef iswap_int4 +# undef iswap_int2 +# define iswap_int8 bswap_64 +# define iswap_int4 bswap_32 +# define iswap_int2 bswap_16 +#endif +#endif + + +/* + * Macros to specify that data read in is of a particular endianness. + * The macros here swap to the appropriate order for the particular machine + * running the macro and return the new answer. These may also be used when + * writing to a file to specify that we wish to write in (eg) big endian + * format. + * + * This leads to efficient code as most of the time these macros are + * trivial. + */ +#ifdef SP_BIG_ENDIAN +#define le_int4(x) iswap_int4((x)) +#define le_int2(x) iswap_int2((x)) +#endif + +#ifdef SP_LITTLE_ENDIAN +#define le_int4(x) (x) +#define le_int2(x) (x) +#endif + +/*----------------------------------------------------------------------------- + * <inttypes.h> definitions, incase they're not present + */ + +#ifndef PRId64 +#define __PRI64__ "l" +#define PRId64 __PRI64__ "d" +#define PRId32 "d" +#define PRId16 "d" +#define PRId8 "d" +#define PRIu64 __PRI64__ "u" +#define PRIu32 "u" +#define PRIu16 "u" +#define PRIu8 "u" +#endif + +/*----------------------------------------------------------------------------- + * Operating system specifics. + * These ought to be done by autoconf, but are legacy code. + */ +/* + * SunOS 4.x + * Even though we use the ANSI gcc, we make use the the standard SunOS 4.x + * libraries and include files, which are non-ansi + */ +#if defined(__sun__) && !defined(__svr4__) +#define SEEK_SET 0 +#define SEEK_CUR 1 +#define SEEK_END 2 +#endif + +/* + * Microsoft Visual C++ + * Windows + */ +#if defined(_MSC_VER) +#define popen _popen +#define pclose _pclose +#define ftruncate(fd,len) _chsize(fd,len) +#endif + + +/* + * Microsoft Windows running MinGW + */ +#if defined(__MINGW32__) +/* #define mkdir(filename,mode) mkdir((filename)) */ +#define sysconf(x) 512 +#define ftruncate(fd,len) _chsize(fd,len) +#endif + +/* Generic WIN32 API issues */ +#ifdef _WIN32 +# ifndef HAVE_FSEEKO +# if __MSVCRT_VERSION__ >= 0x800 + /* if you have MSVCR80 installed then you can use these definitions: */ +# define off_t __int64 +# define fseeko _fseeki64 +# define ftello _ftelli64 +# else + /* otherwise we're stuck with 32-bit file support */ +# define off_t long +# define fseeko fseek +# define ftello ftell +# endif +# endif /* !HAVE_FSEEKO */ +#endif /* _WIN32 */ + +#ifdef __cplusplus +} +#endif + +#endif /*_OS_H_*/
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/pooled_alloc.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,170 @@ +/* +Copyright (c) 2009 Genome Research Ltd. +Author: Rob Davies <rmd@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdlib.h> +#include <stdio.h> +#include <stdint.h> + +#include "cram/pooled_alloc.h" + +//#define TEST_MAIN + +#define PSIZE 1024*1024 + +pool_alloc_t *pool_create(size_t dsize) { + pool_alloc_t *p; + + if (NULL == (p = (pool_alloc_t *)malloc(sizeof(*p)))) + return NULL; + + /* Minimum size is a pointer, for free list */ + dsize = (dsize + sizeof(void *) - 1) & ~(sizeof(void *)-1); + if (dsize < sizeof(void *)) + dsize = sizeof(void *); + p->dsize = dsize; + + p->npools = 0; + p->pools = NULL; + p->free = NULL; + + return p; +} + +static pool_t *new_pool(pool_alloc_t *p) { + size_t n = PSIZE / p->dsize; + pool_t *pool; + + pool = realloc(p->pools, (p->npools + 1) * sizeof(*p->pools)); + if (NULL == pool) return NULL; + p->pools = pool; + pool = &p->pools[p->npools]; + + pool->pool = malloc(n * p->dsize); + if (NULL == pool->pool) return NULL; + + pool->used = 0; + + p->npools++; + + return pool; +} + +void pool_destroy(pool_alloc_t *p) { + size_t i; + + for (i = 0; i < p->npools; i++) { + free(p->pools[i].pool); + } + free(p->pools); + free(p); +} + +void *pool_alloc(pool_alloc_t *p) { + pool_t *pool; + void *ret; + + /* Look on free list */ + if (NULL != p->free) { + ret = p->free; + p->free = *((void **)p->free); + return ret; + } + + /* Look for space in the last pool */ + if (p->npools) { + pool = &p->pools[p->npools - 1]; + if (pool->used + p->dsize < PSIZE) { + ret = ((char *) pool->pool) + pool->used; + pool->used += p->dsize; + return ret; + } + } + + /* Need a new pool */ + pool = new_pool(p); + if (NULL == pool) return NULL; + + pool->used = p->dsize; + return pool->pool; +} + +void pool_free(pool_alloc_t *p, void *ptr) { + *(void **)ptr = p->free; + p->free = ptr; +} + +#ifdef TEST_MAIN +typedef struct { + int x, y, z; +} xyz; + +#define NP 10000 +int main(void) { + int i; + xyz *item; + xyz **items; + pool_alloc_t *p = pool_create(sizeof(xyz)); + + items = (xyz **)malloc(NP * sizeof(*items)); + + for (i = 0; i < NP; i++) { + item = pool_alloc(p); + item->x = i; + item->y = i+1; + item->z = i+2; + items[i] = item; + } + + for (i = 0; i < NP; i++) { + item = items[i]; + if (i % 3) + pool_free(p, item); + } + + for (i = 0; i < NP; i++) { + item = pool_alloc(p); + item->x = 1000000+i; + item->y = 1000000+i+1; + item->z = 1000000+i+2; + } + + for (i = 0; i < NP; i++) { + item = items[i]; + printf("%d\t%d\t%d\t%d\n", i, item->x, item->y, item->z); + pool_free(p, item); + } + + return 0; +} +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/pooled_alloc.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,56 @@ +/* +Copyright (c) 2009 Genome Research Ltd. +Author: Rob Davies <rmd@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _POOLED_ALLOC_H_ +#define _POOLED_ALLOC_H_ + +/* + * Implements a pooled block allocator where all items are the same size, + * but we need many of them. + */ +typedef struct { + void *pool; + size_t used; +} pool_t; + +typedef struct { + size_t dsize; + size_t npools; + pool_t *pools; + void *free; +} pool_alloc_t; + +pool_alloc_t *pool_create(size_t dsize); +void pool_destroy(pool_alloc_t *p); +void *pool_alloc(pool_alloc_t *p); +void pool_free(pool_alloc_t *p, void *ptr); + + +#endif /*_POOLED_ALLOC_H_*/
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/rANS_byte.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,336 @@ +/* rans_byte.h originally from https://github.com/rygorous/ryg_rans + * + * This is a public-domain implementation of several rANS variants. rANS is an + * entropy coder from the ANS family, as described in Jarek Duda's paper + * "Asymmetric numeral systems" (http://arxiv.org/abs/1311.2540). + */ + +/*-------------------------------------------------------------------------- */ + +// Simple byte-aligned rANS encoder/decoder - public domain - Fabian 'ryg' Giesen 2014 +// +// Not intended to be "industrial strength"; just meant to illustrate the general +// idea. + +#ifndef RANS_BYTE_HEADER +#define RANS_BYTE_HEADER + +#include <stdint.h> + +#ifdef assert +#define RansAssert assert +#else +#define RansAssert(x) +#endif + +// READ ME FIRST: +// +// This is designed like a typical arithmetic coder API, but there's three +// twists you absolutely should be aware of before you start hacking: +// +// 1. You need to encode data in *reverse* - last symbol first. rANS works +// like a stack: last in, first out. +// 2. Likewise, the encoder outputs bytes *in reverse* - that is, you give +// it a pointer to the *end* of your buffer (exclusive), and it will +// slowly move towards the beginning as more bytes are emitted. +// 3. Unlike basically any other entropy coder implementation you might +// have used, you can interleave data from multiple independent rANS +// encoders into the same bytestream without any extra signaling; +// you can also just write some bytes by yourself in the middle if +// you want to. This is in addition to the usual arithmetic encoder +// property of being able to switch models on the fly. Writing raw +// bytes can be useful when you have some data that you know is +// incompressible, and is cheaper than going through the rANS encode +// function. Using multiple rANS coders on the same byte stream wastes +// a few bytes compared to using just one, but execution of two +// independent encoders can happen in parallel on superscalar and +// Out-of-Order CPUs, so this can be *much* faster in tight decoding +// loops. +// +// This is why all the rANS functions take the write pointer as an +// argument instead of just storing it in some context struct. + +// -------------------------------------------------------------------------- + +// L ('l' in the paper) is the lower bound of our normalization interval. +// Between this and our byte-aligned emission, we use 31 (not 32!) bits. +// This is done intentionally because exact reciprocals for 31-bit uints +// fit in 32-bit uints: this permits some optimizations during encoding. +#define RANS_BYTE_L (1u << 23) // lower bound of our normalization interval + +// State for a rANS encoder. Yep, that's all there is to it. +typedef uint32_t RansState; + +// Initialize a rANS encoder. +static inline void RansEncInit(RansState* r) +{ + *r = RANS_BYTE_L; +} + +// Renormalize the encoder. Internal function. +static inline RansState RansEncRenorm(RansState x, uint8_t** pptr, uint32_t freq, uint32_t scale_bits) +{ + uint32_t x_max = ((RANS_BYTE_L >> scale_bits) << 8) * freq; // this turns into a shift. + if (x >= x_max) { + uint8_t* ptr = *pptr; + do { + *--ptr = (uint8_t) (x & 0xff); + x >>= 8; + } while (x >= x_max); + *pptr = ptr; + } + return x; +} + +// Encodes a single symbol with range start "start" and frequency "freq". +// All frequencies are assumed to sum to "1 << scale_bits", and the +// resulting bytes get written to ptr (which is updated). +// +// NOTE: With rANS, you need to encode symbols in *reverse order*, i.e. from +// beginning to end! Likewise, the output bytestream is written *backwards*: +// ptr starts pointing at the end of the output buffer and keeps decrementing. +static inline void RansEncPut(RansState* r, uint8_t** pptr, uint32_t start, uint32_t freq, uint32_t scale_bits) +{ + // renormalize + RansState x = RansEncRenorm(*r, pptr, freq, scale_bits); + + // x = C(s,x) + *r = ((x / freq) << scale_bits) + (x % freq) + start; +} + +// Flushes the rANS encoder. +static inline void RansEncFlush(RansState* r, uint8_t** pptr) +{ + uint32_t x = *r; + uint8_t* ptr = *pptr; + + ptr -= 4; + ptr[0] = (uint8_t) (x >> 0); + ptr[1] = (uint8_t) (x >> 8); + ptr[2] = (uint8_t) (x >> 16); + ptr[3] = (uint8_t) (x >> 24); + + *pptr = ptr; +} + +// Initializes a rANS decoder. +// Unlike the encoder, the decoder works forwards as you'd expect. +static inline void RansDecInit(RansState* r, uint8_t** pptr) +{ + uint32_t x; + uint8_t* ptr = *pptr; + + x = ptr[0] << 0; + x |= ptr[1] << 8; + x |= ptr[2] << 16; + x |= ptr[3] << 24; + ptr += 4; + + *pptr = ptr; + *r = x; +} + +// Returns the current cumulative frequency (map it to a symbol yourself!) +static inline uint32_t RansDecGet(RansState* r, uint32_t scale_bits) +{ + return *r & ((1u << scale_bits) - 1); +} + +// Advances in the bit stream by "popping" a single symbol with range start +// "start" and frequency "freq". All frequencies are assumed to sum to "1 << scale_bits", +// and the resulting bytes get written to ptr (which is updated). +static inline void RansDecAdvance(RansState* r, uint8_t** pptr, uint32_t start, uint32_t freq, uint32_t scale_bits) +{ + uint32_t mask = (1u << scale_bits) - 1; + + // s, x = D(x) + uint32_t x = *r; + x = freq * (x >> scale_bits) + (x & mask) - start; + + // renormalize + if (x < RANS_BYTE_L) { + uint8_t* ptr = *pptr; + do x = (x << 8) | *ptr++; while (x < RANS_BYTE_L); + *pptr = ptr; + } + + *r = x; +} + +// -------------------------------------------------------------------------- + +// That's all you need for a full encoder; below here are some utility +// functions with extra convenience or optimizations. + +// Encoder symbol description +// This (admittedly odd) selection of parameters was chosen to make +// RansEncPutSymbol as cheap as possible. +typedef struct { + uint32_t x_max; // (Exclusive) upper bound of pre-normalization interval + uint32_t rcp_freq; // Fixed-point reciprocal frequency + uint32_t bias; // Bias + uint16_t cmpl_freq; // Complement of frequency: (1 << scale_bits) - freq + uint16_t rcp_shift; // Reciprocal shift +} RansEncSymbol; + +// Decoder symbols are straightforward. +typedef struct { + uint16_t start; // Start of range. + uint16_t freq; // Symbol frequency. +} RansDecSymbol; + +// Initializes an encoder symbol to start "start" and frequency "freq" +static inline void RansEncSymbolInit(RansEncSymbol* s, uint32_t start, uint32_t freq, uint32_t scale_bits) +{ + RansAssert(scale_bits <= 16); + RansAssert(start <= (1u << scale_bits)); + RansAssert(freq <= (1u << scale_bits) - start); + + // Say M := 1 << scale_bits. + // + // The original encoder does: + // x_new = (x/freq)*M + start + (x%freq) + // + // The fast encoder does (schematically): + // q = mul_hi(x, rcp_freq) >> rcp_shift (division) + // r = x - q*freq (remainder) + // x_new = q*M + bias + r (new x) + // plugging in r into x_new yields: + // x_new = bias + x + q*(M - freq) + // =: bias + x + q*cmpl_freq (*) + // + // and we can just precompute cmpl_freq. Now we just need to + // set up our parameters such that the original encoder and + // the fast encoder agree. + + s->x_max = ((RANS_BYTE_L >> scale_bits) << 8) * freq; + s->cmpl_freq = (uint16_t) ((1 << scale_bits) - freq); + if (freq < 2) { + // freq=0 symbols are never valid to encode, so it doesn't matter what + // we set our values to. + // + // freq=1 is tricky, since the reciprocal of 1 is 1; unfortunately, + // our fixed-point reciprocal approximation can only multiply by values + // smaller than 1. + // + // So we use the "next best thing": rcp_freq=0xffffffff, rcp_shift=0. + // This gives: + // q = mul_hi(x, rcp_freq) >> rcp_shift + // = mul_hi(x, (1<<32) - 1)) >> 0 + // = floor(x - x/(2^32)) + // = x - 1 if 1 <= x < 2^32 + // and we know that x>0 (x=0 is never in a valid normalization interval). + // + // So we now need to choose the other parameters such that + // x_new = x*M + start + // plug it in: + // x*M + start (desired result) + // = bias + x + q*cmpl_freq (*) + // = bias + x + (x - 1)*(M - 1) (plug in q=x-1, cmpl_freq) + // = bias + 1 + (x - 1)*M + // = x*M + (bias + 1 - M) + // + // so we have start = bias + 1 - M, or equivalently + // bias = start + M - 1. + s->rcp_freq = ~0u; + s->rcp_shift = 0; + s->bias = start + (1 << scale_bits) - 1; + } else { + // Alverson, "Integer Division using reciprocals" + // shift=ceil(log2(freq)) + uint32_t shift = 0; + while (freq > (1u << shift)) + shift++; + + s->rcp_freq = (uint32_t) (((1ull << (shift + 31)) + freq-1) / freq); + s->rcp_shift = shift - 1; + + // With these values, 'q' is the correct quotient, so we + // have bias=start. + s->bias = start; + } + + s->rcp_shift += 32; // Avoid the extra >>32 in RansEncPutSymbol +} + +// Initialize a decoder symbol to start "start" and frequency "freq" +static inline void RansDecSymbolInit(RansDecSymbol* s, uint32_t start, uint32_t freq) +{ + RansAssert(start <= (1 << 16)); + RansAssert(freq <= (1 << 16) - start); + s->start = (uint16_t) start; + s->freq = (uint16_t) freq; +} + +// Encodes a given symbol. This is faster than straight RansEnc since we can do +// multiplications instead of a divide. +// +// See RansEncSymbolInit for a description of how this works. +static inline void RansEncPutSymbol(RansState* r, uint8_t** pptr, RansEncSymbol const* sym) +{ + RansAssert(sym->x_max != 0); // can't encode symbol with freq=0 + + // renormalize + uint32_t x = *r; + uint32_t x_max = sym->x_max; + + if (x >= x_max) { + uint8_t* ptr = *pptr; + do { + *--ptr = (uint8_t) (x & 0xff); + x >>= 8; + } while (x >= x_max); + *pptr = ptr; + } + + // x = C(s,x) + // NOTE: written this way so we get a 32-bit "multiply high" when + // available. If you're on a 64-bit platform with cheap multiplies + // (e.g. x64), just bake the +32 into rcp_shift. + //uint32_t q = (uint32_t) (((uint64_t)x * sym->rcp_freq) >> 32) >> sym->rcp_shift; + + // The extra >>32 has already been added to RansEncSymbolInit + uint32_t q = (uint32_t) (((uint64_t)x * sym->rcp_freq) >> sym->rcp_shift); + *r = x + sym->bias + q * sym->cmpl_freq; +} + +// Equivalent to RansDecAdvance that takes a symbol. +static inline void RansDecAdvanceSymbol(RansState* r, uint8_t** pptr, RansDecSymbol const* sym, uint32_t scale_bits) +{ + RansDecAdvance(r, pptr, sym->start, sym->freq, scale_bits); +} + +// Advances in the bit stream by "popping" a single symbol with range start +// "start" and frequency "freq". All frequencies are assumed to sum to "1 << scale_bits". +// No renormalization or output happens. +static inline void RansDecAdvanceStep(RansState* r, uint32_t start, uint32_t freq, uint32_t scale_bits) +{ + uint32_t mask = (1u << scale_bits) - 1; + + // s, x = D(x) + uint32_t x = *r; + *r = freq * (x >> scale_bits) + (x & mask) - start; +} + +// Equivalent to RansDecAdvanceStep that takes a symbol. +static inline void RansDecAdvanceSymbolStep(RansState* r, RansDecSymbol const* sym, uint32_t scale_bits) +{ + RansDecAdvanceStep(r, sym->start, sym->freq, scale_bits); +} + +// Renormalize. +static inline void RansDecRenorm(RansState* r, uint8_t** pptr) +{ + // renormalize + uint32_t x = *r; + + if (x < RANS_BYTE_L) { + uint8_t* ptr = *pptr; + do x = (x << 8) | *ptr++; while (x < RANS_BYTE_L); + *pptr = ptr; + } + + *r = x; +} + +#endif // RANS_BYTE_HEADER
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/rANS_static.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,841 @@ +/* + * Copyright (c) 2014 Genome Research Ltd. + * Author(s): James Bonfield + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * 1. Redistributions of source code must retain the above copyright notice, + * this list of conditions and the following disclaimer. + * + * 2. Redistributions in binary form must reproduce the above + * copyright notice, this list of conditions and the following + * disclaimer in the documentation and/or other materials provided + * with the distribution. + * + * 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger + * Institute nor the names of its contributors may be used to endorse + * or promote products derived from this software without specific + * prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS + * IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED + * TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A + * PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH + * LTD OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, + * SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT + * LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, + * DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY + * THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT + * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE + * OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + */ + +/* + * Author: James Bonfield, Wellcome Trust Sanger Institute. 2014 + */ + +#include <stdint.h> +#include <stdlib.h> +#include <stdio.h> +#include <unistd.h> +#include <assert.h> +#include <string.h> +#include <sys/time.h> + +#include "cram/rANS_static.h" +#include "cram/rANS_byte.h" + +#define TF_SHIFT 12 +#define TOTFREQ (1<<TF_SHIFT) + +#define ABS(a) ((a)>0?(a):-(a)) +#ifndef BLK_SIZE +# define BLK_SIZE 1024*1024 +#endif + +// Room to allow for expanded BLK_SIZE on worst case compression. +#define BLK_SIZE2 ((int)(1.05*BLK_SIZE)) + +/*----------------------------------------------------------------------------- + * Memory to memory compression functions. + * + * These are original versions without any manual loop unrolling. They + * are easier to understand, but can be up to 2x slower. + */ + +unsigned char *rans_compress_O0(unsigned char *in, unsigned int in_size, + unsigned int *out_size) { + unsigned char *out_buf = malloc(1.05*in_size + 257*257*3 + 9); + unsigned char *cp, *out_end; + RansEncSymbol syms[256]; + RansState rans0, rans1, rans2, rans3; + uint8_t* ptr; + int F[256] = {0}, i, j, tab_size, rle, x, fsum = 0; + int m = 0, M = 0; + uint64_t tr; + + if (!out_buf) + return NULL; + + ptr = out_end = out_buf + (int)(1.05*in_size) + 257*257*3 + 9; + + // Compute statistics + for (i = 0; i < in_size; i++) { + F[in[i]]++; + } + tr = ((uint64_t)TOTFREQ<<31)/in_size + (1<<30)/in_size; + + // Normalise so T[i] == TOTFREQ + for (m = M = j = 0; j < 256; j++) { + if (!F[j]) + continue; + + if (m < F[j]) + m = F[j], M = j; + + if ((F[j] = (F[j]*tr)>>31) == 0) + F[j] = 1; + fsum += F[j]; + } + + fsum++; + if (fsum < TOTFREQ) + F[M] += TOTFREQ-fsum; + else + F[M] -= fsum-TOTFREQ; + + //printf("F[%d]=%d\n", M, F[M]); + assert(F[M]>0); + + // Encode statistics. + cp = out_buf+9; + + for (x = rle = j = 0; j < 256; j++) { + if (F[j]) { + // j + if (rle) { + rle--; + } else { + *cp++ = j; + if (!rle && j && F[j-1]) { + for(rle=j+1; rle<256 && F[rle]; rle++) + ; + rle -= j+1; + *cp++ = rle; + } + //fprintf(stderr, "%d: %d %d\n", j, rle, N[j]); + } + + // F[j] + if (F[j]<128) { + *cp++ = F[j]; + } else { + *cp++ = 128 | (F[j]>>8); + *cp++ = F[j]&0xff; + } + RansEncSymbolInit(&syms[j], x, F[j], TF_SHIFT); + x += F[j]; + } + } + *cp++ = 0; + + //write(1, out_buf+4, cp-(out_buf+4)); + tab_size = cp-out_buf; + + RansEncInit(&rans0); + RansEncInit(&rans1); + RansEncInit(&rans2); + RansEncInit(&rans3); + + switch (i=(in_size&3)) { + case 3: RansEncPutSymbol(&rans2, &ptr, &syms[in[in_size-(i-2)]]); + case 2: RansEncPutSymbol(&rans1, &ptr, &syms[in[in_size-(i-1)]]); + case 1: RansEncPutSymbol(&rans0, &ptr, &syms[in[in_size-(i-0)]]); + case 0: + break; + } + for (i=(in_size &~3); i>0; i-=4) { + RansEncSymbol *s3 = &syms[in[i-1]]; + RansEncSymbol *s2 = &syms[in[i-2]]; + RansEncSymbol *s1 = &syms[in[i-3]]; + RansEncSymbol *s0 = &syms[in[i-4]]; + + RansEncPutSymbol(&rans3, &ptr, s3); + RansEncPutSymbol(&rans2, &ptr, s2); + RansEncPutSymbol(&rans1, &ptr, s1); + RansEncPutSymbol(&rans0, &ptr, s0); + } + + RansEncFlush(&rans3, &ptr); + RansEncFlush(&rans2, &ptr); + RansEncFlush(&rans1, &ptr); + RansEncFlush(&rans0, &ptr); + + // Finalise block size and return it + *out_size = (out_end - ptr) + tab_size; + + cp = out_buf; + + *cp++ = 0; // order + *cp++ = ((*out_size-9)>> 0) & 0xff; + *cp++ = ((*out_size-9)>> 8) & 0xff; + *cp++ = ((*out_size-9)>>16) & 0xff; + *cp++ = ((*out_size-9)>>24) & 0xff; + + *cp++ = (in_size>> 0) & 0xff; + *cp++ = (in_size>> 8) & 0xff; + *cp++ = (in_size>>16) & 0xff; + *cp++ = (in_size>>24) & 0xff; + + memmove(out_buf + tab_size, ptr, out_end-ptr); + + return out_buf; +} + +typedef struct { + struct { + int F; + int C; + } fc[256]; + unsigned char *R; +} ari_decoder; + +unsigned char *rans_uncompress_O0(unsigned char *in, unsigned int in_size, + unsigned int *out_size) { + /* Load in the static tables */ + unsigned char *cp = in + 9; + int i, j, x, out_sz, in_sz, rle; + char *out_buf; + ari_decoder D; + RansDecSymbol syms[256]; + + memset(&D, 0, sizeof(D)); + + if (*in++ != 0) // Order-0 check + return NULL; + + in_sz = ((in[0])<<0) | ((in[1])<<8) | ((in[2])<<16) | ((in[3])<<24); + out_sz = ((in[4])<<0) | ((in[5])<<8) | ((in[6])<<16) | ((in[7])<<24); + if (in_sz != in_size-9) + return NULL; + + out_buf = malloc(out_sz); + if (!out_buf) + return NULL; + + //fprintf(stderr, "out_sz=%d\n", out_sz); + + // Precompute reverse lookup of frequency. + rle = x = 0; + j = *cp++; + do { + if ((D.fc[j].F = *cp++) >= 128) { + D.fc[j].F &= ~128; + D.fc[j].F = ((D.fc[j].F & 127) << 8) | *cp++; + } + D.fc[j].C = x; + + RansDecSymbolInit(&syms[j], D.fc[j].C, D.fc[j].F); + + /* Build reverse lookup table */ + if (!D.R) D.R = (unsigned char *)malloc(TOTFREQ); + memset(&D.R[x], j, D.fc[j].F); + + x += D.fc[j].F; + + if (!rle && j+1 == *cp) { + j = *cp++; + rle = *cp++; + } else if (rle) { + rle--; + j++; + } else { + j = *cp++; + } + } while(j); + + assert(x < TOTFREQ); + + RansState rans0, rans1, rans2, rans3; + uint8_t *ptr = cp; + RansDecInit(&rans0, &ptr); + RansDecInit(&rans1, &ptr); + RansDecInit(&rans2, &ptr); + RansDecInit(&rans3, &ptr); + + int out_end = (out_sz&~3); + + RansState R[4]; + R[0] = rans0; + R[1] = rans1; + R[2] = rans2; + R[3] = rans3; + uint32_t mask = (1u << TF_SHIFT)-1; + + for (i=0; i < out_end; i+=4) { + uint32_t m[4] = {R[0] & mask, + R[1] & mask, + R[2] & mask, + R[3] & mask}; + uint8_t c[4] = {D.R[m[0]], + D.R[m[1]], + D.R[m[2]], + D.R[m[3]]}; + out_buf[i+0] = c[0]; + out_buf[i+1] = c[1]; + out_buf[i+2] = c[2]; + out_buf[i+3] = c[3]; + + // RansDecAdvanceSymbolStep(&R[0], &syms[c[0]], TF_SHIFT); + // RansDecAdvanceSymbolStep(&R[1], &syms[c[1]], TF_SHIFT); + // RansDecAdvanceSymbolStep(&R[2], &syms[c[2]], TF_SHIFT); + // RansDecAdvanceSymbolStep(&R[3], &syms[c[3]], TF_SHIFT); + R[0] = syms[c[0]].freq * (R[0]>>TF_SHIFT); + R[1] = syms[c[1]].freq * (R[1]>>TF_SHIFT); + R[2] = syms[c[2]].freq * (R[2]>>TF_SHIFT); + R[3] = syms[c[3]].freq * (R[3]>>TF_SHIFT); + + R[0] += m[0] - syms[c[0]].start; + R[1] += m[1] - syms[c[1]].start; + R[2] += m[2] - syms[c[2]].start; + R[3] += m[3] - syms[c[3]].start; + + RansDecRenorm(&R[0], &ptr); + RansDecRenorm(&R[1], &ptr); + RansDecRenorm(&R[2], &ptr); + RansDecRenorm(&R[3], &ptr); + } + + rans0 = R[0]; + rans1 = R[1]; + rans2 = R[2]; + rans3 = R[3]; + + switch(out_sz&3) { + unsigned char c; + case 0: + break; + case 1: + c = D.R[RansDecGet(&rans0, TF_SHIFT)]; + RansDecAdvanceSymbol(&rans0, &ptr, &syms[c], TF_SHIFT); + out_buf[out_end] = c; + break; + + case 2: + c = D.R[RansDecGet(&rans0, TF_SHIFT)]; + RansDecAdvanceSymbol(&rans0, &ptr, &syms[c], TF_SHIFT); + out_buf[out_end] = c; + + c = D.R[RansDecGet(&rans1, TF_SHIFT)]; + RansDecAdvanceSymbol(&rans1, &ptr, &syms[c], TF_SHIFT); + out_buf[out_end+1] = c; + break; + + case 3: + c = D.R[RansDecGet(&rans0, TF_SHIFT)]; + RansDecAdvanceSymbol(&rans0, &ptr, &syms[c], TF_SHIFT); + out_buf[out_end] = c; + + c = D.R[RansDecGet(&rans1, TF_SHIFT)]; + RansDecAdvanceSymbol(&rans1, &ptr, &syms[c], TF_SHIFT); + out_buf[out_end+1] = c; + + c = D.R[RansDecGet(&rans2, TF_SHIFT)]; + RansDecAdvanceSymbol(&rans2, &ptr, &syms[c], TF_SHIFT); + out_buf[out_end+2] = c; + break; + } + + *out_size = out_sz; + + if (D.R) free(D.R); + + return (unsigned char *)out_buf; +} + +unsigned char *rans_compress_O1(unsigned char *in, unsigned int in_size, + unsigned int *out_size) { + unsigned char *out_buf, *out_end, *cp; + unsigned int last_i, tab_size, rle_i, rle_j; + RansEncSymbol syms[256][256]; + + if (in_size < 4) + return rans_compress_O0(in, in_size, out_size); + + out_buf = malloc(1.05*in_size + 257*257*3 + 9); + if (!out_buf) + return NULL; + + out_end = out_buf + (int)(1.05*in_size) + 257*257*3 + 9; + cp = out_buf+9; + + int F[256][256], T[256], i, j; + unsigned char c; + + memset(F, 0, 256*256*sizeof(int)); + memset(T, 0, 256*sizeof(int)); + //for (last = 0, i=in_size-1; i>=0; i--) { + // F[last][c = in[i]]++; + // T[last]++; + // last = c; + //} + + for (last_i=i=0; i<in_size; i++) { + F[last_i][c = in[i]]++; + T[last_i]++; + last_i = c; + } + F[0][in[1*(in_size>>2)]]++; + F[0][in[2*(in_size>>2)]]++; + F[0][in[3*(in_size>>2)]]++; + T[0]+=3; + + // Normalise so T[i] == TOTFREQ + for (rle_i = i = 0; i < 256; i++) { + int t2, m, M; + unsigned int x; + + if (T[i] == 0) + continue; + + //uint64_t p = (TOTFREQ * TOTFREQ) / t; + double p = ((double)TOTFREQ)/T[i]; + for (t2 = m = M = j = 0; j < 256; j++) { + if (!F[i][j]) + continue; + + if (m < F[i][j]) + m = F[i][j], M = j; + + //if ((F[i][j] = (F[i][j] * p) / TOTFREQ) == 0) + if ((F[i][j] *= p) == 0) + F[i][j] = 1; + t2 += F[i][j]; + } + + t2++; + if (t2 < TOTFREQ) + F[i][M] += TOTFREQ-t2; + else + F[i][M] -= t2-TOTFREQ; + + // Store frequency table + // i + if (rle_i) { + rle_i--; + } else { + *cp++ = i; + // FIXME: could use order-0 statistics to observe which alphabet + // symbols are present and base RLE on that ordering instead. + if (i && T[i-1]) { + for(rle_i=i+1; rle_i<256 && T[rle_i]; rle_i++) + ; + rle_i -= i+1; + *cp++ = rle_i; + } + } + + int *F_i_ = F[i]; + x = 0; + rle_j = 0; + for (j = 0; j < 256; j++) { + if (F_i_[j]) { + //fprintf(stderr, "F[%d][%d]=%d, x=%d\n", i, j, F_i_[j], x); + + // j + if (rle_j) { + rle_j--; + } else { + *cp++ = j; + if (!rle_j && j && F_i_[j-1]) { + for(rle_j=j+1; rle_j<256 && F_i_[rle_j]; rle_j++) + ; + rle_j -= j+1; + *cp++ = rle_j; + } + } + + // F_i_[j] + if (F_i_[j]<128) { + *cp++ = F_i_[j]; + } else { + *cp++ = 128 | (F_i_[j]>>8); + *cp++ = F_i_[j]&0xff; + } + + RansEncSymbolInit(&syms[i][j], x, F_i_[j], TF_SHIFT); + x += F_i_[j]; + } + } + *cp++ = 0; + } + *cp++ = 0; + + //write(1, out_buf+4, cp-(out_buf+4)); + tab_size = cp - out_buf; + assert(tab_size < 257*257*3); + + RansState rans0, rans1, rans2, rans3; + RansEncInit(&rans0); + RansEncInit(&rans1); + RansEncInit(&rans2); + RansEncInit(&rans3); + + uint8_t* ptr = out_end; + + int isz4 = in_size>>2; + int i0 = 1*isz4-2; + int i1 = 2*isz4-2; + int i2 = 3*isz4-2; + int i3 = 4*isz4-2; + + unsigned char l0 = in[i0+1]; + unsigned char l1 = in[i1+1]; + unsigned char l2 = in[i2+1]; + unsigned char l3 = in[i3+1]; + + // Deal with the remainder + l3 = in[in_size-1]; + for (i3 = in_size-2; i3 > 4*isz4-2; i3--) { + unsigned char c3 = in[i3]; + RansEncPutSymbol(&rans3, &ptr, &syms[c3][l3]); + l3 = c3; + } + + for (; i0 >= 0; i0--, i1--, i2--, i3--) { + unsigned char c0, c1, c2, c3; + RansEncSymbol *s3 = &syms[c3 = in[i3]][l3]; + RansEncSymbol *s2 = &syms[c2 = in[i2]][l2]; + RansEncSymbol *s1 = &syms[c1 = in[i1]][l1]; + RansEncSymbol *s0 = &syms[c0 = in[i0]][l0]; + + RansEncPutSymbol(&rans3, &ptr, s3); + RansEncPutSymbol(&rans2, &ptr, s2); + RansEncPutSymbol(&rans1, &ptr, s1); + RansEncPutSymbol(&rans0, &ptr, s0); + + l0 = c0; + l1 = c1; + l2 = c2; + l3 = c3; + } + + RansEncPutSymbol(&rans3, &ptr, &syms[0][l3]); + RansEncPutSymbol(&rans2, &ptr, &syms[0][l2]); + RansEncPutSymbol(&rans1, &ptr, &syms[0][l1]); + RansEncPutSymbol(&rans0, &ptr, &syms[0][l0]); + + RansEncFlush(&rans3, &ptr); + RansEncFlush(&rans2, &ptr); + RansEncFlush(&rans1, &ptr); + RansEncFlush(&rans0, &ptr); + + *out_size = (out_end - ptr) + tab_size; + + cp = out_buf; + *cp++ = 1; // order + + *cp++ = ((*out_size-9)>> 0) & 0xff; + *cp++ = ((*out_size-9)>> 8) & 0xff; + *cp++ = ((*out_size-9)>>16) & 0xff; + *cp++ = ((*out_size-9)>>24) & 0xff; + + *cp++ = (in_size>> 0) & 0xff; + *cp++ = (in_size>> 8) & 0xff; + *cp++ = (in_size>>16) & 0xff; + *cp++ = (in_size>>24) & 0xff; + + memmove(out_buf + tab_size, ptr, out_end-ptr); + + return out_buf; +} + +unsigned char *rans_uncompress_O1(unsigned char *in, unsigned int in_size, + unsigned int *out_size) { + /* Load in the static tables */ + unsigned char *cp = in + 9; + int i, j = -999, x, out_sz, in_sz, rle_i, rle_j; + char *out_buf; + ari_decoder D[256]; + RansDecSymbol syms[256][256]; + + memset(D, 0, 256*sizeof(*D)); + + if (*in++ != 1) // Order-1 check + return NULL; + + in_sz = ((in[0])<<0) | ((in[1])<<8) | ((in[2])<<16) | ((in[3])<<24); + out_sz = ((in[4])<<0) | ((in[5])<<8) | ((in[6])<<16) | ((in[7])<<24); + if (in_sz != in_size-9) + return NULL; + + out_buf = malloc(out_sz); + if (!out_buf) + return NULL; + + //fprintf(stderr, "out_sz=%d\n", out_sz); + + //i = *cp++; + rle_i = 0; + i = *cp++; + do { + rle_j = x = 0; + j = *cp++; + do { + if ((D[i].fc[j].F = *cp++) >= 128) { + D[i].fc[j].F &= ~128; + D[i].fc[j].F = ((D[i].fc[j].F & 127) << 8) | *cp++; + } + D[i].fc[j].C = x; + + //fprintf(stderr, "i=%d j=%d F=%d C=%d\n", i, j, D[i].fc[j].F, D[i].fc[j].C); + + if (!D[i].fc[j].F) + D[i].fc[j].F = TOTFREQ; + + RansDecSymbolInit(&syms[i][j], D[i].fc[j].C, D[i].fc[j].F); + + /* Build reverse lookup table */ + if (!D[i].R) D[i].R = (unsigned char *)malloc(TOTFREQ); + memset(&D[i].R[x], j, D[i].fc[j].F); + + x += D[i].fc[j].F; + assert(x <= TOTFREQ); + + if (!rle_j && j+1 == *cp) { + j = *cp++; + rle_j = *cp++; + } else if (rle_j) { + rle_j--; + j++; + } else { + j = *cp++; + } + } while(j); + + if (!rle_i && i+1 == *cp) { + i = *cp++; + rle_i = *cp++; + } else if (rle_i) { + rle_i--; + i++; + } else { + i = *cp++; + } + } while (i); + + // Precompute reverse lookup of frequency. + + RansState rans0, rans1, rans2, rans3; + uint8_t *ptr = cp; + RansDecInit(&rans0, &ptr); + RansDecInit(&rans1, &ptr); + RansDecInit(&rans2, &ptr); + RansDecInit(&rans3, &ptr); + + int isz4 = out_sz>>2; + int l0 = 0; + int l1 = 0; + int l2 = 0; + int l3 = 0; + int i4[] = {0*isz4, 1*isz4, 2*isz4, 3*isz4}; + + RansState R[4]; + R[0] = rans0; + R[1] = rans1; + R[2] = rans2; + R[3] = rans3; + + for (; i4[0] < isz4; i4[0]++, i4[1]++, i4[2]++, i4[3]++) { + uint32_t m[4] = {R[0] & ((1u << TF_SHIFT)-1), + R[1] & ((1u << TF_SHIFT)-1), + R[2] & ((1u << TF_SHIFT)-1), + R[3] & ((1u << TF_SHIFT)-1)}; + + uint8_t c[4] = {D[l0].R[m[0]], + D[l1].R[m[1]], + D[l2].R[m[2]], + D[l3].R[m[3]]}; + + out_buf[i4[0]] = c[0]; + out_buf[i4[1]] = c[1]; + out_buf[i4[2]] = c[2]; + out_buf[i4[3]] = c[3]; + + //RansDecAdvanceSymbolStep(&R[0], &syms[l0][c[0]], TF_SHIFT); + //RansDecAdvanceSymbolStep(&R[1], &syms[l1][c[1]], TF_SHIFT); + //RansDecAdvanceSymbolStep(&R[2], &syms[l2][c[2]], TF_SHIFT); + //RansDecAdvanceSymbolStep(&R[3], &syms[l3][c[3]], TF_SHIFT); + + R[0] = syms[l0][c[0]].freq * (R[0]>>TF_SHIFT); + R[1] = syms[l1][c[1]].freq * (R[1]>>TF_SHIFT); + R[2] = syms[l2][c[2]].freq * (R[2]>>TF_SHIFT); + R[3] = syms[l3][c[3]].freq * (R[3]>>TF_SHIFT); + + R[0] += m[0] - syms[l0][c[0]].start; + R[1] += m[1] - syms[l1][c[1]].start; + R[2] += m[2] - syms[l2][c[2]].start; + R[3] += m[3] - syms[l3][c[3]].start; + + RansDecRenorm(&R[0], &ptr); + RansDecRenorm(&R[1], &ptr); + RansDecRenorm(&R[2], &ptr); + RansDecRenorm(&R[3], &ptr); + + l0 = c[0]; + l1 = c[1]; + l2 = c[2]; + l3 = c[3]; + } + + rans0 = R[0]; + rans1 = R[1]; + rans2 = R[2]; + rans3 = R[3]; + + // Remainder + for (; i4[3] < out_sz; i4[3]++) { + unsigned char c3 = D[l3].R[RansDecGet(&rans3, TF_SHIFT)]; + out_buf[i4[3]] = c3; + RansDecAdvanceSymbol(&rans3, &ptr, &syms[l3][c3], TF_SHIFT); + l3 = c3; + } + + *out_size = out_sz; + + for (i = 0; i < 256; i++) + if (D[i].R) free(D[i].R); + + return (unsigned char *)out_buf; +} + +/*----------------------------------------------------------------------------- + * Simple interface to the order-0 vs order-1 encoders and decoders. + */ +unsigned char *rans_compress(unsigned char *in, unsigned int in_size, + unsigned int *out_size, int order) { + return order + ? rans_compress_O1(in, in_size, out_size) + : rans_compress_O0(in, in_size, out_size); +} + +unsigned char *rans_uncompress(unsigned char *in, unsigned int in_size, + unsigned int *out_size) { + return in[0] + ? rans_uncompress_O1(in, in_size, out_size) + : rans_uncompress_O0(in, in_size, out_size); +} + + +#ifdef TEST_MAIN +/*----------------------------------------------------------------------------- + * Main. + * + * This is a simple command line tool for testing order-0 and order-1 + * compression using the rANS codec. Simply compile with + * + * gcc -DTEST_MAIN -O3 -I. cram/rANS_static.c -o cram/rANS_static + * + * Usage: cram/rANS_static -o0 < file > file.o0 + * cram/rANS_static -d < file.o0 > file2 + * + * cram/rANS_static -o1 < file > file.o1 + * cram/rANS_static -d < file.o1 > file2 + */ +int main(int argc, char **argv) { + int opt, order = 0; + unsigned char in_buf[BLK_SIZE2+257*257*3]; + int decode = 0; + FILE *infp = stdin, *outfp = stdout; + struct timeval tv1, tv2; + size_t bytes = 0; + + extern char *optarg; + extern int optind; + + while ((opt = getopt(argc, argv, "o:d")) != -1) { + switch (opt) { + case 'o': + order = atoi(optarg); + break; + + case 'd': + decode = 1; + break; + } + } + + order = order ? 1 : 0; // Only support O(0) and O(1) + + if (optind < argc) { + if (!(infp = fopen(argv[optind], "rb"))) { + perror(argv[optind]); + return 1; + } + optind++; + } + + if (optind < argc) { + if (!(outfp = fopen(argv[optind], "wb"))) { + perror(argv[optind]); + return 1; + } + optind++; + } + + gettimeofday(&tv1, NULL); + + if (decode) { + // Only used in some test implementations of RC_GetFreq() + //RC_init(); + //RC_init2(); + + for (;;) { + uint32_t in_size, out_size; + unsigned char *out; + + if (4 != fread(&in_size, 1, 4, infp)) + break; + if (in_size != fread(in_buf, 1, in_size, infp)) { + fprintf(stderr, "Truncated input\n"); + exit(1); + } + out = rans_uncompress(in_buf, in_size, &out_size); + if (!out) + abort(); + + fwrite(out, 1, out_size, outfp); + free(out); + + bytes += out_size; + } + } else { + for (;;) { + uint32_t in_size, out_size; + unsigned char *out; + + in_size = fread(in_buf, 1, BLK_SIZE, infp); + if (in_size <= 0) + break; + + out = rans_compress(in_buf, in_size, &out_size, order); + + fwrite(&out_size, 1, 4, outfp); + fwrite(out, 1, out_size, outfp); + free(out); + + bytes += in_size; + } + } + + gettimeofday(&tv2, NULL); + + fprintf(stderr, "Took %ld microseconds, %5.1f MB/s\n", + (long)(tv2.tv_sec - tv1.tv_sec)*1000000 + + tv2.tv_usec - tv1.tv_usec, + (double)bytes / ((long)(tv2.tv_sec - tv1.tv_sec)*1000000 + + tv2.tv_usec - tv1.tv_usec)); + return 0; +} +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/rANS_static.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,44 @@ +/* + * Copyright (c) 2014 Genome Research Ltd. + * Author(s): James Bonfield + * + * Redistribution and use in source and binary forms, with or without + * modification, are permitted provided that the following conditions are met: + * + * 1. Redistributions of source code must retain the above copyright notice, + * this list of conditions and the following disclaimer. + * + * 2. Redistributions in binary form must reproduce the above + * copyright notice, this list of conditions and the following + * disclaimer in the documentation and/or other materials provided + * with the distribution. + * + * 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger + * Institute nor the names of its contributors may be used to endorse + * or promote products derived from this software without specific + * prior written permission. + * + * THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS + * IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED + * TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A + * PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH + * LTD OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, + * SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT + * LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, + * DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY + * THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT + * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE + * OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + */ + + +#ifndef RANS_STATIC_H +#define RANS_STATIC_H + +unsigned char *rans_compress(unsigned char *in, unsigned int in_size, + unsigned int *out_size, int order); +unsigned char *rans_uncompress(unsigned char *in, unsigned int in_size, + unsigned int *out_size); + + +#endif /* RANS_STATIC_H */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/sam_header.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1218 @@ +/* +Copyright (c) 2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <string.h> +#include <assert.h> + +#include "cram/sam_header.h" +#include "cram/string_alloc.h" + +static void sam_hdr_error(char *msg, char *line, int len, int lno) { + int j; + + for (j = 0; j < len && line[j] != '\n'; j++) + ; + fprintf(stderr, "%s at line %d: \"%.*s\"\n", msg, lno, j, line); +} + +void sam_hdr_dump(SAM_hdr *hdr) { + khint_t k; + int i; + + printf("===DUMP===\n"); + for (k = kh_begin(hdr->h); k != kh_end(hdr->h); k++) { + SAM_hdr_type *t1, *t2; + char c[2]; + + if (!kh_exist(hdr->h, k)) + continue; + + t1 = t2 = kh_val(hdr->h, k); + c[0] = kh_key(hdr->h, k)>>8; + c[1] = kh_key(hdr->h, k)&0xff; + printf("Type %.2s, count %d\n", c, t1->prev->order+1); + + do { + SAM_hdr_tag *tag; + printf(">>>%d ", t1->order); + for (tag = t1->tag; tag; tag=tag->next) { + printf("\"%.2s\":\"%.*s\"\t", + tag->str, tag->len-3, tag->str+3); + } + putchar('\n'); + t1 = t1->next; + } while (t1 != t2); + } + + /* Dump out PG chains */ + printf("\n@PG chains:\n"); + for (i = 0; i < hdr->npg_end; i++) { + int j; + printf(" %d:", i); + for (j = hdr->pg_end[i]; j != -1; j = hdr->pg[j].prev_id) { + printf("%s%d(%.*s)", + j == hdr->pg_end[i] ? " " : "->", + j, hdr->pg[j].name_len, hdr->pg[j].name); + } + printf("\n"); + } + + puts("===END DUMP==="); +} + +/* Updates the hash tables in the SAM_hdr structure. + * + * Returns 0 on success; + * -1 on failure + */ +static int sam_hdr_update_hashes(SAM_hdr *sh, + int type, + SAM_hdr_type *h_type) { + /* Add to reference hash? */ + if ((type>>8) == 'S' && (type&0xff) == 'Q') { + SAM_hdr_tag *tag; + int nref = sh->nref; + + sh->ref = realloc(sh->ref, (sh->nref+1)*sizeof(*sh->ref)); + if (!sh->ref) + return -1; + + tag = h_type->tag; + sh->ref[nref].name = NULL; + sh->ref[nref].len = 0; + sh->ref[nref].ty = h_type; + sh->ref[nref].tag = tag; + + while (tag) { + if (tag->str[0] == 'S' && tag->str[1] == 'N') { + if (!(sh->ref[nref].name = malloc(tag->len))) + return -1; + strncpy(sh->ref[nref].name, tag->str+3, tag->len-3); + sh->ref[nref].name[tag->len-3] = 0; + } else if (tag->str[0] == 'L' && tag->str[1] == 'N') { + sh->ref[nref].len = atoi(tag->str+3); + } + tag = tag->next; + } + + if (sh->ref[nref].name) { + khint_t k; + int r; + k = kh_put(m_s2i, sh->ref_hash, sh->ref[nref].name, &r); + if (-1 == r) return -1; + kh_val(sh->ref_hash, k) = nref; + } + + sh->nref++; + } + + /* Add to read-group hash? */ + if ((type>>8) == 'R' && (type&0xff) == 'G') { + SAM_hdr_tag *tag; + int nrg = sh->nrg; + + sh->rg = realloc(sh->rg, (sh->nrg+1)*sizeof(*sh->rg)); + if (!sh->rg) + return -1; + + tag = h_type->tag; + sh->rg[nrg].name = NULL; + sh->rg[nrg].name_len = 0; + sh->rg[nrg].ty = h_type; + sh->rg[nrg].tag = tag; + sh->rg[nrg].id = nrg; + + while (tag) { + if (tag->str[0] == 'I' && tag->str[1] == 'D') { + if (!(sh->rg[nrg].name = malloc(tag->len))) + return -1; + strncpy(sh->rg[nrg].name, tag->str+3, tag->len-3); + sh->rg[nrg].name[tag->len-3] = 0; + sh->rg[nrg].name_len = strlen(sh->rg[nrg].name); + } + tag = tag->next; + } + + if (sh->rg[nrg].name) { + khint_t k; + int r; + k = kh_put(m_s2i, sh->rg_hash, sh->rg[nrg].name, &r); + if (-1 == r) return -1; + kh_val(sh->rg_hash, k) = nrg; + } + + sh->nrg++; + } + + /* Add to program hash? */ + if ((type>>8) == 'P' && (type&0xff) == 'G') { + SAM_hdr_tag *tag; + int npg = sh->npg; + + sh->pg = realloc(sh->pg, (sh->npg+1)*sizeof(*sh->pg)); + if (!sh->pg) + return -1; + + tag = h_type->tag; + sh->pg[npg].name = NULL; + sh->pg[npg].name_len = 0; + sh->pg[npg].ty = h_type; + sh->pg[npg].tag = tag; + sh->pg[npg].id = npg; + sh->pg[npg].prev_id = -1; + + while (tag) { + if (tag->str[0] == 'I' && tag->str[1] == 'D') { + if (!(sh->pg[npg].name = malloc(tag->len))) + return -1; + strncpy(sh->pg[npg].name, tag->str+3, tag->len-3); + sh->pg[npg].name[tag->len-3] = 0; + sh->pg[npg].name_len = strlen(sh->pg[npg].name); + } else if (tag->str[0] == 'P' && tag->str[1] == 'P') { + // Resolve later if needed + khint_t k; + char tmp = tag->str[tag->len]; tag->str[tag->len] = 0; + k = kh_get(m_s2i, sh->pg_hash, tag->str+3); + tag->str[tag->len] = tmp; + + if (k != kh_end(sh->pg_hash)) { + int p_id = kh_val(sh->pg_hash, k); + sh->pg[npg].prev_id = sh->pg[p_id].id; + + /* Unmark previous entry as a PG termination */ + if (sh->npg_end > 0 && + sh->pg_end[sh->npg_end-1] == p_id) { + sh->npg_end--; + } else { + int i; + for (i = 0; i < sh->npg_end; i++) { + if (sh->pg_end[i] == p_id) { + memmove(&sh->pg_end[i], &sh->pg_end[i+1], + (sh->npg_end-i-1)*sizeof(*sh->pg_end)); + sh->npg_end--; + } + } + } + } else { + sh->pg[npg].prev_id = -1; + } + } + tag = tag->next; + } + + if (sh->pg[npg].name) { + khint_t k; + int r; + k = kh_put(m_s2i, sh->pg_hash, sh->pg[npg].name, &r); + if (-1 == r) return -1; + kh_val(sh->pg_hash, k) = npg; + } + + /* Add to npg_end[] array. Remove later if we find a PP line */ + if (sh->npg_end >= sh->npg_end_alloc) { + sh->npg_end_alloc = sh->npg_end_alloc + ? sh->npg_end_alloc*2 + : 4; + sh->pg_end = realloc(sh->pg_end, + sh->npg_end_alloc * sizeof(int)); + if (!sh->pg_end) + return -1; + } + sh->pg_end[sh->npg_end++] = npg; + + sh->npg++; + } + + return 0; +} + +/* + * Appends a formatted line to an existing SAM header. + * Line is a full SAM header record, eg "@SQ\tSN:foo\tLN:100", with + * optional new-line. If it contains more than 1 line then multiple lines + * will be added in order. + * + * Len is the length of the text data, or 0 if unknown (in which case + * it should be null terminated). + * + * Returns 0 on success + * -1 on failure + */ +int sam_hdr_add_lines(SAM_hdr *sh, const char *lines, int len) { + int i, lno = 1, text_offset; + char *hdr; + + if (!len) + len = strlen(lines); + + text_offset = ks_len(&sh->text); + if (EOF == kputsn(lines, len, &sh->text)) + return -1; + hdr = ks_str(&sh->text) + text_offset; + + for (i = 0; i < len; i++) { + khint32_t type; + khint_t k; + + int l_start = i, new; + SAM_hdr_type *h_type; + SAM_hdr_tag *h_tag, *last; + + if (hdr[i] != '@') { + int j; + for (j = i; j < len && hdr[j] != '\n'; j++) + ; + sam_hdr_error("Header line does not start with '@'", + &hdr[l_start], len - l_start, lno); + return -1; + } + + type = (hdr[i+1]<<8) | hdr[i+2]; + if (hdr[i+1] < 'A' || hdr[i+1] > 'z' || + hdr[i+2] < 'A' || hdr[i+2] > 'z') { + sam_hdr_error("Header line does not have a two character key", + &hdr[l_start], len - l_start, lno); + return -1; + } + + i += 3; + if (hdr[i] == '\n') + continue; + + // Add the header line type + if (!(h_type = pool_alloc(sh->type_pool))) + return -1; + if (-1 == (k = kh_put(sam_hdr, sh->h, type, &new))) + return -1; + + // Form the ring, either with self or other lines of this type + if (!new) { + SAM_hdr_type *t = kh_val(sh->h, k), *p; + p = t->prev; + + assert(p->next = t); + p->next = h_type; + h_type->prev = p; + + t->prev = h_type; + h_type->next = t; + h_type->order = p->order+1; + } else { + kh_val(sh->h, k) = h_type; + h_type->prev = h_type->next = h_type; + h_type->order = 0; + } + + // Parse the tags on this line + last = NULL; + if ((type>>8) == 'C' && (type&0xff) == 'O') { + int j; + if (hdr[i] != '\t') { + sam_hdr_error("Missing tab", + &hdr[l_start], len - l_start, lno); + return -1; + } + + for (j = ++i; j < len && hdr[j] != '\n'; j++) + ; + + if (!(h_type->tag = h_tag = pool_alloc(sh->tag_pool))) + return -1; + h_tag->str = string_ndup(sh->str_pool, &hdr[i], j-i); + h_tag->len = j-i; + h_tag->next = NULL; + if (!h_tag->str) + return -1; + + i = j; + + } else { + do { + int j; + if (hdr[i] != '\t') { + sam_hdr_error("Missing tab", + &hdr[l_start], len - l_start, lno); + return -1; + } + + for (j = ++i; j < len && hdr[j] != '\n' && hdr[j] != '\t'; j++) + ; + + if (!(h_tag = pool_alloc(sh->tag_pool))) + return -1; + h_tag->str = string_ndup(sh->str_pool, &hdr[i], j-i); + h_tag->len = j-i; + h_tag->next = NULL; + if (!h_tag->str) + return -1; + + if (h_tag->len < 3 || h_tag->str[2] != ':') { + sam_hdr_error("Malformed key:value pair", + &hdr[l_start], len - l_start, lno); + return -1; + } + + if (last) + last->next = h_tag; + else + h_type->tag = h_tag; + + last = h_tag; + i = j; + } while (i < len && hdr[i] != '\n'); + } + + /* Update RG/SQ hashes */ + if (-1 == sam_hdr_update_hashes(sh, type, h_type)) + return -1; + } + + return 0; +} + +/* + * Adds a single line to a SAM header. + * Specify type and one or more key,value pairs, ending with the NULL key. + * Eg. sam_hdr_add(h, "SQ", "ID", "foo", "LN", "100", NULL). + * + * Returns index for specific entry on success (eg 2nd SQ, 4th RG) + * -1 on failure + */ +int sam_hdr_add(SAM_hdr *sh, const char *type, ...) { + va_list args; + va_start(args, type); + return sam_hdr_vadd(sh, type, args, NULL); +} + +int sam_hdr_vadd(SAM_hdr *sh, const char *type, va_list ap, ...) { + va_list args; + SAM_hdr_type *h_type; + SAM_hdr_tag *h_tag, *last; + int new; + khint32_t type_i = (type[0]<<8) | type[1], k; + +#if defined(HAVE_VA_COPY) + va_list ap_local; +#endif + + if (EOF == kputc_('@', &sh->text)) + return -1; + if (EOF == kputsn(type, 2, &sh->text)) + return -1; + + if (!(h_type = pool_alloc(sh->type_pool))) + return -1; + if (-1 == (k = kh_put(sam_hdr, sh->h, type_i, &new))) + return -1; + kh_val(sh->h, k) = h_type; + + // Form the ring, either with self or other lines of this type + if (!new) { + SAM_hdr_type *t = kh_val(sh->h, k), *p; + p = t->prev; + + assert(p->next = t); + p->next = h_type; + h_type->prev = p; + + t->prev = h_type; + h_type->next = t; + h_type->order = p->order + 1; + } else { + h_type->prev = h_type->next = h_type; + h_type->order = 0; + } + + last = NULL; + + // Any ... varargs + va_start(args, ap); + for (;;) { + char *k, *v; + int idx; + + if (!(k = (char *)va_arg(args, char *))) + break; + v = va_arg(args, char *); + + if (EOF == kputc_('\t', &sh->text)) + return -1; + + if (!(h_tag = pool_alloc(sh->tag_pool))) + return -1; + idx = ks_len(&sh->text); + + if (EOF == kputs(k, &sh->text)) + return -1; + if (EOF == kputc_(':', &sh->text)) + return -1; + if (EOF == kputs(v, &sh->text)) + return -1; + + h_tag->len = ks_len(&sh->text) - idx; + h_tag->str = string_ndup(sh->str_pool, + ks_str(&sh->text) + idx, + h_tag->len); + h_tag->next = NULL; + if (!h_tag->str) + return -1; + + if (last) + last->next = h_tag; + else + h_type->tag = h_tag; + + last = h_tag; + } + va_end(args); + +#if defined(HAVE_VA_COPY) + va_copy(ap_local, ap); +# define ap ap_local +#endif + + // Plus the specified va_list params + for (;;) { + char *k, *v; + int idx; + + if (!(k = (char *)va_arg(ap, char *))) + break; + v = va_arg(ap, char *); + + if (EOF == kputc_('\t', &sh->text)) + return -1; + + if (!(h_tag = pool_alloc(sh->tag_pool))) + return -1; + idx = ks_len(&sh->text); + + if (EOF == kputs(k, &sh->text)) + return -1; + if (EOF == kputc_(':', &sh->text)) + return -1; + if (EOF == kputs(v, &sh->text)) + return -1; + + h_tag->len = ks_len(&sh->text) - idx; + h_tag->str = string_ndup(sh->str_pool, + ks_str(&sh->text) + idx, + h_tag->len); + h_tag->next = NULL; + if (!h_tag->str) + return -1; + + if (last) + last->next = h_tag; + else + h_type->tag = h_tag; + + last = h_tag; + } + va_end(ap); + + if (EOF == kputc('\n', &sh->text)) + return -1; + + int itype = (type[0]<<8) | type[1]; + if (-1 == sam_hdr_update_hashes(sh, itype, h_type)) + return -1; + + return h_type->order; +} + +/* + * Returns the first header item matching 'type'. If ID is non-NULL it checks + * for the tag ID: and compares against the specified ID. + * + * Returns NULL if no type/ID is found + */ +SAM_hdr_type *sam_hdr_find(SAM_hdr *hdr, char *type, + char *ID_key, char *ID_value) { + SAM_hdr_type *t1, *t2; + int itype = (type[0]<<8)|(type[1]); + khint_t k; + + /* Special case for types we have prebuilt hashes on */ + if (ID_key) { + if (type[0] == 'S' && type[1] == 'Q' && + ID_key[0] == 'S' && ID_key[1] == 'N') { + k = kh_get(m_s2i, hdr->ref_hash, ID_value); + return k != kh_end(hdr->ref_hash) + ? hdr->ref[kh_val(hdr->ref_hash, k)].ty + : NULL; + } + + if (type[0] == 'R' && type[1] == 'G' && + ID_key[0] == 'I' && ID_key[1] == 'D') { + k = kh_get(m_s2i, hdr->rg_hash, ID_value); + return k != kh_end(hdr->rg_hash) + ? hdr->rg[kh_val(hdr->rg_hash, k)].ty + : NULL; + } + + if (type[0] == 'P' && type[1] == 'G' && + ID_key[0] == 'I' && ID_key[1] == 'D') { + k = kh_get(m_s2i, hdr->pg_hash, ID_value); + return k != kh_end(hdr->pg_hash) + ? hdr->pg[kh_val(hdr->pg_hash, k)].ty + : NULL; + } + } + + k = kh_get(sam_hdr, hdr->h, itype); + if (k == kh_end(hdr->h)) + return NULL; + + if (!ID_key) + return kh_val(hdr->h, k); + + t1 = t2 = kh_val(hdr->h, k); + do { + SAM_hdr_tag *tag; + for (tag = t1->tag; tag; tag = tag->next) { + if (tag->str[0] == ID_key[0] && tag->str[1] == ID_key[1]) { + char *cp1 = tag->str+3; + char *cp2 = ID_value; + while (*cp1 && *cp1 == *cp2) + cp1++, cp2++; + if (*cp2 || *cp1) + continue; + return t1; + } + } + t1 = t1->next; + } while (t1 != t2); + + return NULL; +} + +/* + * As per SAM_hdr_type, but returns a complete line of formatted text + * for a specific head type/ID combination. If ID is NULL then it returns + * the first line of the specified type. + * + * The returned string is malloced and should be freed by the calling + * function with free(). + * + * Returns NULL if no type/ID is found. + */ +char *sam_hdr_find_line(SAM_hdr *hdr, char *type, + char *ID_key, char *ID_value) { + SAM_hdr_type *ty = sam_hdr_find(hdr, type, ID_key, ID_value); + kstring_t ks = KS_INITIALIZER; + SAM_hdr_tag *tag; + int r = 0; + + if (!ty) + return NULL; + + // Paste together the line from the hashed copy + r |= (kputc_('@', &ks) == EOF); + r |= (kputs(type, &ks) == EOF); + for (tag = ty->tag; tag; tag = tag->next) { + r |= (kputc_('\t', &ks) == EOF); + r |= (kputsn(tag->str, tag->len, &ks) == EOF); + } + + if (r) { + KS_FREE(&ks); + return NULL; + } + + return ks_str(&ks); +} + + +/* + * Looks for a specific key in a single sam header line. + * If prev is non-NULL it also fills this out with the previous tag, to + * permit use in key removal. *prev is set to NULL when the tag is the first + * key in the list. When a tag isn't found, prev (if non NULL) will be the last + * tag in the existing list. + * + * Returns the tag pointer on success + * NULL on failure + */ +SAM_hdr_tag *sam_hdr_find_key(SAM_hdr *sh, + SAM_hdr_type *type, + char *key, + SAM_hdr_tag **prev) { + SAM_hdr_tag *tag, *p = NULL; + + for (tag = type->tag; tag; p = tag, tag = tag->next) { + if (tag->str[0] == key[0] && tag->str[1] == key[1]) { + if (prev) + *prev = p; + return tag; + } + } + + if (prev) + *prev = p; + + return NULL; +} + + +/* + * Adds or updates tag key,value pairs in a header line. + * Eg for adding M5 tags to @SQ lines or updating sort order for the + * @HD line (although use the sam_hdr_sort_order() function for + * HD manipulation, which is a wrapper around this funuction). + * + * Specify multiple key,value pairs ending in NULL. + * + * Returns 0 on success + * -1 on failure + */ +int sam_hdr_update(SAM_hdr *hdr, SAM_hdr_type *type, ...) { + va_list ap; + + va_start(ap, type); + + for (;;) { + char *k, *v; + int idx; + SAM_hdr_tag *tag, *prev; + + if (!(k = (char *)va_arg(ap, char *))) + break; + v = va_arg(ap, char *); + + tag = sam_hdr_find_key(hdr, type, k, &prev); + if (!tag) { + if (!(tag = pool_alloc(hdr->tag_pool))) + return -1; + if (prev) + prev->next = tag; + else + type->tag = tag; + + tag->next = NULL; + } + + idx = ks_len(&hdr->text); + if (ksprintf(&hdr->text, "%2.2s:%s", k, v) < 0) + return -1; + tag->len = ks_len(&hdr->text) - idx; + tag->str = string_ndup(hdr->str_pool, + ks_str(&hdr->text) + idx, + tag->len); + if (!tag->str) + return -1; + } + + va_end(ap); + + return 0; +} + +#define K(a) (((a)[0]<<8)|((a)[1])) + +/* + * Reconstructs the kstring from the header hash table. + * Returns 0 on success + * -1 on failure + */ +int sam_hdr_rebuild(SAM_hdr *hdr) { + /* Order: HD then others */ + kstring_t ks = KS_INITIALIZER; + khint_t k; + + + k = kh_get(sam_hdr, hdr->h, K("HD")); + if (k != kh_end(hdr->h)) { + SAM_hdr_type *ty = kh_val(hdr->h, k); + SAM_hdr_tag *tag; + if (EOF == kputs("@HD", &ks)) + return -1; + for (tag = ty->tag; tag; tag = tag->next) { + if (EOF == kputc_('\t', &ks)) + return -1; + if (EOF == kputsn_(tag->str, tag->len, &ks)) + return -1; + } + if (EOF == kputc('\n', &ks)) + return -1; + } + + for (k = kh_begin(hdr->h); k != kh_end(hdr->h); k++) { + SAM_hdr_type *t1, *t2; + + if (!kh_exist(hdr->h, k)) + continue; + + if (kh_key(hdr->h, k) == K("HD")) + continue; + + t1 = t2 = kh_val(hdr->h, k); + do { + SAM_hdr_tag *tag; + char c[2]; + + if (EOF == kputc_('@', &ks)) + return -1; + c[0] = kh_key(hdr->h, k)>>8; + c[1] = kh_key(hdr->h, k)&0xff; + if (EOF == kputsn_(c, 2, &ks)) + return -1; + for (tag = t1->tag; tag; tag=tag->next) { + if (EOF == kputc_('\t', &ks)) + return -1; + if (EOF == kputsn_(tag->str, tag->len, &ks)) + return -1; + } + if (EOF == kputc('\n', &ks)) + return -1; + t1 = t1->next; + } while (t1 != t2); + } + + if (ks_str(&hdr->text)) + KS_FREE(&hdr->text); + + hdr->text = ks; + + return 0; +} + + +/* + * Creates an empty SAM header, ready to be populated. + * + * Returns a SAM_hdr struct on success (free with sam_hdr_free()) + * NULL on failure + */ +SAM_hdr *sam_hdr_new() { + SAM_hdr *sh = calloc(1, sizeof(*sh)); + + if (!sh) + return NULL; + + sh->h = kh_init(sam_hdr); + if (!sh->h) + goto err; + + sh->ID_cnt = 1; + sh->ref_count = 1; + + sh->nref = 0; + sh->ref = NULL; + if (!(sh->ref_hash = kh_init(m_s2i))) + goto err; + + sh->nrg = 0; + sh->rg = NULL; + if (!(sh->rg_hash = kh_init(m_s2i))) + goto err; + + sh->npg = 0; + sh->pg = NULL; + sh->npg_end = sh->npg_end_alloc = 0; + sh->pg_end = NULL; + if (!(sh->pg_hash = kh_init(m_s2i))) + goto err; + + KS_INIT(&sh->text); + + if (!(sh->tag_pool = pool_create(sizeof(SAM_hdr_tag)))) + goto err; + + if (!(sh->type_pool = pool_create(sizeof(SAM_hdr_type)))) + goto err; + + if (!(sh->str_pool = string_pool_create(8192))) + goto err; + + return sh; + + err: + if (sh->h) + kh_destroy(sam_hdr, sh->h); + + if (sh->tag_pool) + pool_destroy(sh->tag_pool); + + if (sh->type_pool) + pool_destroy(sh->type_pool); + + if (sh->str_pool) + string_pool_destroy(sh->str_pool); + + free(sh); + + return NULL; +} + + +/* + * Tokenises a SAM header into a hash table. + * Also extracts a few bits on specific data types, such as @RG lines. + * + * Returns a SAM_hdr struct on success (free with sam_hdr_free()) + * NULL on failure + */ +SAM_hdr *sam_hdr_parse_(const char *hdr, int len) { + /* Make an empty SAM_hdr */ + SAM_hdr *sh; + + sh = sam_hdr_new(); + if (NULL == sh) return NULL; + + if (NULL == hdr) return sh; // empty header is permitted + + /* Parse the header, line by line */ + if (-1 == sam_hdr_add_lines(sh, hdr, len)) { + sam_hdr_free(sh); + return NULL; + } + + //sam_hdr_dump(sh); + //sam_hdr_add(sh, "RG", "ID", "foo", "SM", "bar", NULL); + //sam_hdr_rebuild(sh); + //printf(">>%s<<", ks_str(sh->text)); + + //parse_references(sh); + //parse_read_groups(sh); + + sam_hdr_link_pg(sh); + //sam_hdr_dump(sh); + + return sh; +} + +/* + * Produces a duplicate copy of hdr and returns it. + * Returns NULL on failure + */ +SAM_hdr *sam_hdr_dup(SAM_hdr *hdr) { + if (-1 == sam_hdr_rebuild(hdr)) + return NULL; + + return sam_hdr_parse_(sam_hdr_str(hdr), sam_hdr_length(hdr)); +} + +/*! Increments a reference count on hdr. + * + * This permits multiple files to share the same header, all calling + * sam_hdr_free when done, without causing errors for other open files. + */ +void sam_hdr_incr_ref(SAM_hdr *hdr) { + hdr->ref_count++; +} + +/*! Increments a reference count on hdr. + * + * This permits multiple files to share the same header, all calling + * sam_hdr_free when done, without causing errors for other open files. + * + * If the reference count hits zero then the header is automatically + * freed. This makes it a synonym for sam_hdr_free(). + */ +void sam_hdr_decr_ref(SAM_hdr *hdr) { + sam_hdr_free(hdr); +} + +/*! Deallocates all storage used by a SAM_hdr struct. + * + * This also decrements the header reference count. If after decrementing + * it is still non-zero then the header is assumed to be in use by another + * caller and the free is not done. + * + * This is a synonym for sam_hdr_dec_ref(). + */ +void sam_hdr_free(SAM_hdr *hdr) { + if (!hdr) + return; + + if (--hdr->ref_count > 0) + return; + + if (ks_str(&hdr->text)) + KS_FREE(&hdr->text); + + if (hdr->h) + kh_destroy(sam_hdr, hdr->h); + + if (hdr->ref_hash) + kh_destroy(m_s2i, hdr->ref_hash); + + if (hdr->ref) { + int i; + for (i = 0; i < hdr->nref; i++) + if (hdr->ref[i].name) + free(hdr->ref[i].name); + free(hdr->ref); + } + + if (hdr->rg_hash) + kh_destroy(m_s2i, hdr->rg_hash); + + if (hdr->rg) { + int i; + for (i = 0; i < hdr->nrg; i++) + if (hdr->rg[i].name) + free(hdr->rg[i].name); + free(hdr->rg); + } + + if (hdr->pg_hash) + kh_destroy(m_s2i, hdr->pg_hash); + + if (hdr->pg) { + int i; + for (i = 0; i < hdr->npg; i++) + if (hdr->pg[i].name) + free(hdr->pg[i].name); + free(hdr->pg); + } + + if (hdr->pg_end) + free(hdr->pg_end); + + if (hdr->type_pool) + pool_destroy(hdr->type_pool); + + if (hdr->tag_pool) + pool_destroy(hdr->tag_pool); + + if (hdr->str_pool) + string_pool_destroy(hdr->str_pool); + + free(hdr); +} + +int sam_hdr_length(SAM_hdr *hdr) { + return ks_len(&hdr->text); +} + +char *sam_hdr_str(SAM_hdr *hdr) { + return ks_str(&hdr->text); +} + +/* + * Looks up a reference sequence by name and returns the numerical ID. + * Returns -1 if unknown reference. + */ +int sam_hdr_name2ref(SAM_hdr *hdr, const char *ref) { + khint_t k = kh_get(m_s2i, hdr->ref_hash, ref); + return k == kh_end(hdr->ref_hash) ? -1 : kh_val(hdr->ref_hash, k); +} + +/* + * Looks up a read-group by name and returns a pointer to the start of the + * associated tag list. + * + * Returns NULL on failure + */ +SAM_RG *sam_hdr_find_rg(SAM_hdr *hdr, const char *rg) { + khint_t k = kh_get(m_s2i, hdr->rg_hash, rg); + return k == kh_end(hdr->rg_hash) + ? NULL + : &hdr->rg[kh_val(hdr->rg_hash, k)]; +} + + +/* + * Fixes any PP links in @PG headers. + * If the entries are in order then this doesn't need doing, but incase + * our header is out of order this goes through the sh->pg[] array + * setting the prev_id field. + * + * Note we can have multiple complete chains. This code should identify the + * tails of these chains as these are the entries we have to link to in + * subsequent PP records. + * + * Returns 0 on sucess + * -1 on failure (indicating broken PG/PP records) + */ +int sam_hdr_link_pg(SAM_hdr *hdr) { + int i, j, ret = 0; + + hdr->npg_end_alloc = hdr->npg; + hdr->pg_end = realloc(hdr->pg_end, hdr->npg * sizeof(*hdr->pg_end)); + if (!hdr->pg_end) + return -1; + + for (i = 0; i < hdr->npg; i++) + hdr->pg_end[i] = i; + + for (i = 0; i < hdr->npg; i++) { + khint_t k; + SAM_hdr_tag *tag; + char tmp; + + for (tag = hdr->pg[i].tag; tag; tag = tag->next) { + if (tag->str[0] == 'P' && tag->str[1] == 'P') + break; + } + if (!tag) { + /* Chain start points */ + continue; + } + + tmp = tag->str[tag->len]; tag->str[tag->len] = 0; + k = kh_get(m_s2i, hdr->pg_hash, tag->str+3); + tag->str[tag->len] = tmp; + + if (k == kh_end(hdr->pg_hash)) { + ret = -1; + continue; + } + + hdr->pg[i].prev_id = hdr->pg[kh_val(hdr->pg_hash, k)].id; + hdr->pg_end[kh_val(hdr->pg_hash, k)] = -1; + } + + for (i = j = 0; i < hdr->npg; i++) { + if (hdr->pg_end[i] != -1) + hdr->pg_end[j++] = hdr->pg_end[i]; + } + hdr->npg_end = j; + + return ret; +} + +/* + * Returns a unique ID from a base name. + * + * The value returned is valid until the next call to + * this function. + */ +const char *sam_hdr_PG_ID(SAM_hdr *sh, const char *name) { + khint_t k = kh_get(m_s2i, sh->pg_hash, name); + if (k == kh_end(sh->pg_hash)) + return name; + + do { + sprintf(sh->ID_buf, "%.1000s.%d", name, sh->ID_cnt++); + k = kh_get(m_s2i, sh->pg_hash, sh->ID_buf); + } while (k == kh_end(sh->pg_hash)); + + return sh->ID_buf; +} + +/* + * Add an @PG line. + * + * If we wish complete control over this use sam_hdr_add() directly. This + * function uses that, but attempts to do a lot of tedious house work for + * you too. + * + * - It will generate a suitable ID if the supplied one clashes. + * - It will generate multiple @PG records if we have multiple PG chains. + * + * Call it as per sam_hdr_add() with a series of key,value pairs ending + * in NULL. + * + * Returns 0 on success + * -1 on failure + */ +int sam_hdr_add_PG(SAM_hdr *sh, const char *name, ...) { + va_list args; + va_start(args, name); + + if (sh->npg_end) { + /* Copy ends array to avoid us looping while modifying it */ + int *end = malloc(sh->npg_end * sizeof(int)); + int i, nends = sh->npg_end; + + if (!end) + return -1; + + memcpy(end, sh->pg_end, nends * sizeof(*end)); + + for (i = 0; i < nends; i++) { + if (-1 == sam_hdr_vadd(sh, "PG", args, + "ID", sam_hdr_PG_ID(sh, name), + "PN", name, + "PP", sh->pg[end[i]].name, + NULL)) { + free(end); + return -1; + } + } + + free(end); + } else { + if (-1 == sam_hdr_vadd(sh, "PG", args, + "ID", sam_hdr_PG_ID(sh, name), + "PN", name, + NULL)) + return -1; + } + + //sam_hdr_dump(sh); + + return 0; +} + +/* + * A function to help with construction of CL tags in @PG records. + * Takes an argc, argv pair and returns a single space-separated string. + * This string should be deallocated by the calling function. + * + * Returns malloced char * on success + * NULL on failure + */ +char *stringify_argv(int argc, char *argv[]) { + char *str, *cp; + size_t nbytes = 1; + int i, j; + + /* Allocate */ + for (i = 0; i < argc; i++) { + nbytes += strlen(argv[i]) + 1; + } + if (!(str = malloc(nbytes))) + return NULL; + + /* Copy */ + cp = str; + for (i = 0; i < argc; i++) { + j = 0; + while (argv[i][j]) { + if (argv[i][j] == '\t') + *cp++ = ' '; + else + *cp++ = argv[i][j]; + j++; + } + *cp++ = ' '; + } + *cp++ = 0; + + return str; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/sam_header.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,444 @@ +/* +Copyright (c) 2013-2014 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/*! \file + * SAM header parsing. + * + * These functions can be shared between SAM, BAM and CRAM file + * formats as all three internally use the same string encoding for + * header fields. + */ + +/* + * TODO. + * + * - Sort order (parse to struct, enum type, updating funcs) + * - Removal of lines. + * - Updating of lines + */ + +#ifndef _SAM_HDR_H_ +#define _SAM_HDR_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdarg.h> + +#include "cram/string_alloc.h" +#include "cram/pooled_alloc.h" + +#include "htslib/khash.h" +#include "htslib/kstring.h" + +// For structure assignment. Eg kstring_t s = KS_INITIALIZER; +#define KS_INITIALIZER {0,0,0} + +// For initialisation elsewhere. Eg KS_INIT(x->str); +#define KS_INIT(ks) ((ks)->l = 0, (ks)->m = 0, (ks)->s = NULL) + +// Frees the string subfield only. Assumes 's' itself is static. +#define KS_FREE(ks) do { if ((ks)->s) free((ks)->s); } while(0) + +/* + * Proposed new SAM header parsing + +1 @SQ ID:foo LN:100 +2 @SQ ID:bar LN:200 +3 @SQ ID:ram LN:300 UR:xyz +4 @RG ID:r ... +5 @RG ID:s ... + +Hash table for 2-char @keys without dup entries. +If dup lines, we form a circular linked list. Ie hash keys = {RG, SQ}. + +HASH("SQ")--\ + | + (3) <-> 1 <-> 2 <-> 3 <-> (1) + +HASH("RG")--\ + | + (5) <-> 4 <-> 5 <-> (4) + +Items stored in the hash values also form their own linked lists: +Ie SQ->ID(foo)->LN(100) + SQ->ID(bar)->LN(200) + SQ->ID(ram)->LN(300)->UR(xyz) + RG->ID(r) + */ + +/*! A single key:value pair on a header line + * + * These form a linked list and hold strings. The strings are + * allocated from a string_alloc_t pool referenced in the master + * SAM_hdr structure. Do not attempt to free, malloc or manipulate + * these strings directly. + */ +typedef struct SAM_hdr_tag_s { + struct SAM_hdr_tag_s *next; + char *str; + int len; +} SAM_hdr_tag; + +/*! The parsed version of the SAM header string. + * + * Each header type (SQ, RG, HD, etc) points to its own SAM_hdr_type + * struct via the main hash table h in the SAM_hdr struct. + * + * These in turn consist of circular bi-directional linked lists (ie + * rings) to hold the multiple instances of the same header type + * code. For example if we have 5 \@SQ lines the primary hash table + * will key on \@SQ pointing to the first SAM_hdr_type and that in turn + * will be part of a ring of 5 elements. + * + * For each SAM_hdr_type structure we also point to a SAM_hdr_tag + * structure which holds the tokenised attributes; the tab separated + * key:value pairs per line. + */ +typedef struct SAM_hdr_item_s { + struct SAM_hdr_item_s *next; // cirular + struct SAM_hdr_item_s *prev; + SAM_hdr_tag *tag; // first tag + int order; // 0 upwards +} SAM_hdr_type; + +/*! Parsed \@SQ lines */ +typedef struct { + char *name; + uint32_t len; + SAM_hdr_type *ty; + SAM_hdr_tag *tag; +} SAM_SQ; + +/*! Parsed \@RG lines */ +typedef struct { + char *name; + SAM_hdr_type *ty; + SAM_hdr_tag *tag; + int name_len; + int id; // numerical ID +} SAM_RG; + +/*! Parsed \@PG lines */ +typedef struct { + char *name; + SAM_hdr_type *ty; + SAM_hdr_tag *tag; + int name_len; + int id; // numerical ID + int prev_id; // -1 if none +} SAM_PG; + +KHASH_MAP_INIT_INT(sam_hdr, SAM_hdr_type*) +KHASH_MAP_INIT_STR(m_s2i, int) + +/*! Primary structure for header manipulation + * + * The initial header text is held in the text kstring_t, but is also + * parsed out into SQ, RG and PG arrays. These have a hash table + * associated with each to allow lookup by ID or SN fields instead of + * their numeric array indices. Additionally PG has an array to hold + * the linked list start points (the last in a PP chain). + * + * Use the appropriate sam_hdr_* functions to edit the header, and + * call sam_hdr_rebuild() any time the textual form needs to be + * updated again. + */ +typedef struct { + kstring_t text; //!< concatenated text, indexed by SAM_hdr_tag + khash_t(sam_hdr) *h; + string_alloc_t *str_pool; //!< Pool of SAM_hdr_tag->str strings + pool_alloc_t *type_pool;//!< Pool of SAM_hdr_type structs + pool_alloc_t *tag_pool; //!< Pool of SAM_hdr_tag structs + + // @SQ lines / references + int nref; //!< Number of \@SQ lines + SAM_SQ *ref; //!< Array of parsed \@SQ lines + khash_t(m_s2i) *ref_hash; //!< Maps SQ SN field to sq[] index + + // @RG lines / read-groups + int nrg; //!< Number of \@RG lines + SAM_RG *rg; //!< Array of parsed \@RG lines + khash_t(m_s2i) *rg_hash; //!< Maps RG ID field to rg[] index + + // @PG lines / programs + int npg; //!< Number of \@PG lines + int npg_end; //!< Number of terminating \@PG lines + int npg_end_alloc; //!< Size of pg_end field + SAM_PG *pg; //!< Array of parsed \@PG lines + khash_t(m_s2i) *pg_hash; //!< Maps PG ID field to pg[] index + int *pg_end; //!< \@PG chain termination IDs + + // @cond internal + char ID_buf[1024]; // temporary buffer + int ID_cnt; + int ref_count; // number of uses of this SAM_hdr + // @endcond +} SAM_hdr; + +/*! Creates an empty SAM header, ready to be populated. + * + * @return + * Returns a SAM_hdr struct on success (free with sam_hdr_free()) + * NULL on failure + */ +SAM_hdr *sam_hdr_new(void); + +/*! Tokenises a SAM header into a hash table. + * + * Also extracts a few bits on specific data types, such as @RG lines. + * + * @return + * Returns a SAM_hdr struct on success (free with sam_hdr_free()); + * NULL on failure + */ +SAM_hdr *sam_hdr_parse_(const char *hdr, int len); + + +/*! Produces a duplicate copy of hdr and returns it. + * @return + * Returns NULL on failure + */ +SAM_hdr *sam_hdr_dup(SAM_hdr *hdr); + + +/*! Increments a reference count on hdr. + * + * This permits multiple files to share the same header, all calling + * sam_hdr_free when done, without causing errors for other open files. + */ +void sam_hdr_incr_ref(SAM_hdr *hdr); + + +/*! Increments a reference count on hdr. + * + * This permits multiple files to share the same header, all calling + * sam_hdr_free when done, without causing errors for other open files. + * + * If the reference count hits zero then the header is automatically + * freed. This makes it a synonym for sam_hdr_free(). + */ +void sam_hdr_decr_ref(SAM_hdr *hdr); + + +/*! Deallocates all storage used by a SAM_hdr struct. + * + * This also decrements the header reference count. If after decrementing + * it is still non-zero then the header is assumed to be in use by another + * caller and the free is not done. + * + * This is a synonym for sam_hdr_dec_ref(). + */ +void sam_hdr_free(SAM_hdr *hdr); + +/*! Returns the current length of the SAM_hdr in text form. + * + * Call sam_hdr_rebuild() first if editing has taken place. + */ +int sam_hdr_length(SAM_hdr *hdr); + +/*! Returns the string form of the SAM_hdr. + * + * Call sam_hdr_rebuild() first if editing has taken place. + */ +char *sam_hdr_str(SAM_hdr *hdr); + +/*! Appends a formatted line to an existing SAM header. + * + * Line is a full SAM header record, eg "@SQ\tSN:foo\tLN:100", with + * optional new-line. If it contains more than 1 line then multiple lines + * will be added in order. + * + * Len is the length of the text data, or 0 if unknown (in which case + * it should be null terminated). + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int sam_hdr_add_lines(SAM_hdr *sh, const char *lines, int len); + +/*! Adds a single line to a SAM header. + * + * Specify type and one or more key,value pairs, ending with the NULL key. + * Eg. sam_hdr_add(h, "SQ", "ID", "foo", "LN", "100", NULL). + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int sam_hdr_add(SAM_hdr *sh, const char *type, ...); + +/*! Adds a single line to a SAM header. + * + * This is much like sam_hdr_add() but with the additional va_list + * argument. This is followed by specifying type and one or more + * key,value pairs, ending with the NULL key. + * + * Eg. sam_hdr_vadd(h, "SQ", args, "ID", "foo", "LN", "100", NULL). + * + * The purpose of the additional va_list parameter is to permit other + * varargs functions to call this while including their own additional + * parameters; an example is in sam_hdr_add_PG(). + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int sam_hdr_vadd(SAM_hdr *sh, const char *type, va_list ap, ...); + +/*! + * @return + * Returns the first header item matching 'type'. If ID is non-NULL it checks + * for the tag ID: and compares against the specified ID. + * + * Returns NULL if no type/ID is found + */ +SAM_hdr_type *sam_hdr_find(SAM_hdr *hdr, char *type, + char *ID_key, char *ID_value); + +/*! + * + * As per SAM_hdr_type, but returns a complete line of formatted text + * for a specific head type/ID combination. If ID is NULL then it returns + * the first line of the specified type. + * + * The returned string is malloced and should be freed by the calling + * function with free(). + * + * @return + * Returns NULL if no type/ID is found. + */ +char *sam_hdr_find_line(SAM_hdr *hdr, char *type, + char *ID_key, char *ID_value); + +/*! Looks for a specific key in a single sam header line. + * + * If prev is non-NULL it also fills this out with the previous tag, to + * permit use in key removal. *prev is set to NULL when the tag is the first + * key in the list. When a tag isn't found, prev (if non NULL) will be the last + * tag in the existing list. + * + * @return + * Returns the tag pointer on success; + * NULL on failure + */ +SAM_hdr_tag *sam_hdr_find_key(SAM_hdr *sh, + SAM_hdr_type *type, + char *key, + SAM_hdr_tag **prev); + +/*! Adds or updates tag key,value pairs in a header line. + * + * Eg for adding M5 tags to @SQ lines or updating sort order for the + * @HD line (although use the sam_hdr_sort_order() function for + * HD manipulation, which is a wrapper around this funuction). + * + * Specify multiple key,value pairs ending in NULL. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int sam_hdr_update(SAM_hdr *hdr, SAM_hdr_type *type, ...); + +/*! Reconstructs the kstring from the header hash table. + * @return + * Returns 0 on success; + * -1 on failure + */ +int sam_hdr_rebuild(SAM_hdr *hdr); + +/*! Looks up a reference sequence by name and returns the numerical ID. + * @return + * Returns -1 if unknown reference. + */ +int sam_hdr_name2ref(SAM_hdr *hdr, const char *ref); + +/*! Looks up a read-group by name and returns a pointer to the start of the + * associated tag list. + * + * @return + * Returns NULL on failure + */ +SAM_RG *sam_hdr_find_rg(SAM_hdr *hdr, const char *rg); + +/*! Fixes any PP links in @PG headers. + * + * If the entries are in order then this doesn't need doing, but incase + * our header is out of order this goes through the sh->pg[] array + * setting the prev_id field. + * + * @return + * Returns 0 on sucess; + * -1 on failure (indicating broken PG/PP records) + */ +int sam_hdr_link_pg(SAM_hdr *hdr); + + +/*! Add an @PG line. + * + * If we wish complete control over this use sam_hdr_add() directly. This + * function uses that, but attempts to do a lot of tedious house work for + * you too. + * + * - It will generate a suitable ID if the supplied one clashes. + * - It will generate multiple @PG records if we have multiple PG chains. + * + * Call it as per sam_hdr_add() with a series of key,value pairs ending + * in NULL. + * + * @return + * Returns 0 on success; + * -1 on failure + */ +int sam_hdr_add_PG(SAM_hdr *sh, const char *name, ...); + +/*! + * A function to help with construction of CL tags in @PG records. + * Takes an argc, argv pair and returns a single space-separated string. + * This string should be deallocated by the calling function. + * + * @return + * Returns malloced char * on success; + * NULL on failure + */ +char *stringify_argv(int argc, char *argv[]); + +#ifdef __cplusplus +} +#endif + +#endif /* _SAM_HDR_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/string_alloc.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,153 @@ +/* +Copyright (c) 2010 Genome Research Ltd. +Author: Andrew Whitwham <aw7@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + + +/* + A pooled string allocator intended to cut down on the + memory overhead of many small string allocations. + + Andrew Whitwham, September 2010. +*/ + +#include <string.h> +#include <stdlib.h> +#include <stdio.h> + +#include "string_alloc.h" + +#define MIN_STR_SIZE 1024 + + +/* creates the string pool. max_length is the initial size + a single string can be. Tha max_length can grow as + needed */ + +string_alloc_t *string_pool_create(size_t max_length) { + string_alloc_t *a_str; + + if (NULL == (a_str = (string_alloc_t *)malloc(sizeof(*a_str)))) { + return NULL; + } + + if (max_length < MIN_STR_SIZE) max_length = MIN_STR_SIZE; + + a_str->nstrings = 0; + a_str->max_length = max_length; + a_str->strings = NULL; + + return a_str; +} + + +/* internal function to do the actual memory allocation */ + +static string_t *new_string_pool(string_alloc_t *a_str) { + string_t *str; + + str = realloc(a_str->strings, (a_str->nstrings + 1) * sizeof(*a_str->strings)); + + if (NULL == str) return NULL; + + a_str->strings = str; + str = &a_str->strings[a_str->nstrings]; + + str->str = malloc(a_str->max_length);; + + if (NULL == str->str) return NULL; + + str->used = 0; + a_str->nstrings++; + + return str; +} + + +/* free allocated memory */ + +void string_pool_destroy(string_alloc_t *a_str) { + size_t i; + + for (i = 0; i < a_str->nstrings; i++) { + free(a_str->strings[i].str); + } + + free(a_str->strings); + free(a_str); +} + + +/* allocate space for a string */ + +char *string_alloc(string_alloc_t *a_str, size_t length) { + string_t *str; + char *ret; + + if (length <= 0) return NULL; + + // add to last string pool if we have space + if (a_str->nstrings) { + str = &a_str->strings[a_str->nstrings - 1]; + + if (str->used + length < a_str->max_length) { + ret = str->str + str->used; + str->used += length; + return ret; + } + } + + // increase the max length if needs be + if (length > a_str->max_length) a_str->max_length = length; + + // need a new string pool + str = new_string_pool(a_str); + + if (NULL == str) return NULL; + + str->used = length; + return str->str; +} + + +/* equivalent to strdup */ + +char *string_dup(string_alloc_t *a_str, char *instr) { + return string_ndup(a_str, instr, strlen(instr)); +} + +char *string_ndup(string_alloc_t *a_str, char *instr, size_t len) { + char *str = string_alloc(a_str, len + 1); + + if (NULL == str) return NULL; + + strncpy(str, instr, len); + str[len] = 0; + + return str; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/string_alloc.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,69 @@ +/* +Copyright (c) 2010 Genome Research Ltd. +Author: Andrew Whitwham <aw7@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _STRING_ALLOC_H_ +#define _STRING_ALLOC_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +#include <stdlib.h> + +/* + * A pooled string allocator intended to cut down on the + * memory overhead of many small string allocations. + * + * Andrew Whitwham, September 2010. + */ + +typedef struct { + char *str; + size_t used; +} string_t; + +typedef struct { + size_t max_length; + size_t nstrings; + string_t *strings; +} string_alloc_t; + +string_alloc_t *string_pool_create(size_t max_length); +void string_pool_destroy(string_alloc_t *a_str); +char *string_alloc(string_alloc_t *a_str, size_t length); +char *string_dup(string_alloc_t *a_str, char *instr); +char *string_ndup(string_alloc_t *a_str, char *instr, size_t len); + +#endif + +#ifdef __cplusplus +} +#endif +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/thread_pool.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,811 @@ +/* +Copyright (c) 2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#include <stdlib.h> + +#include <signal.h> +#include <errno.h> +#include <stdio.h> +#include <string.h> +#include <sys/time.h> +#include <assert.h> + +#include "cram/thread_pool.h" + +//#define DEBUG +//#define DEBUG_TIME + +#define IN_ORDER + +#ifdef DEBUG +static int worker_id(t_pool *p) { + int i; + pthread_t s = pthread_self(); + for (i = 0; i < p->tsize; i++) { + if (pthread_equal(s, p->t[i].tid)) + return i; + } + return -1; +} +#endif + +/* ---------------------------------------------------------------------------- + * A queue to hold results from the thread pool. + * + * Each thread pool may have jobs of multiple types being queued up and + * interleaved, so we allow several results queue per pool. + * + * The jobs themselves are expected to push their results onto their + * appropriate results queue. + */ + +/* + * Adds a result to the end of the result queue. + * + * Returns 0 on success; + * -1 on failure + */ +static int t_pool_add_result(t_pool_job *j, void *data) { + t_results_queue *q = j->q; + t_pool_result *r; + +#ifdef DEBUG + fprintf(stderr, "%d: Adding resulting to queue %p, serial %d\n", + worker_id(j->p), q, j->serial); +#endif + + /* No results queue is fine if we don't want any results back */ + if (!q) + return 0; + + if (!(r = malloc(sizeof(*r)))) + return -1; + + r->next = NULL; + r->data = data; + r->serial = j->serial; + + pthread_mutex_lock(&q->result_m); + if (q->result_tail) { + q->result_tail->next = r; + q->result_tail = r; + } else { + q->result_head = q->result_tail = r; + } + q->queue_len++; + q->pending--; + +#ifdef DEBUG + fprintf(stderr, "%d: Broadcasting result_avail (id %d)\n", + worker_id(j->p), r->serial); +#endif + pthread_cond_signal(&q->result_avail_c); +#ifdef DEBUG + fprintf(stderr, "%d: Broadcast complete\n", worker_id(j->p)); +#endif + + pthread_mutex_unlock(&q->result_m); + + return 0; +} + +/* Core of t_pool_next_result() */ +static t_pool_result *t_pool_next_result_locked(t_results_queue *q) { + t_pool_result *r, *last; + + for (last = NULL, r = q->result_head; r; last = r, r = r->next) { + if (r->serial == q->next_serial) + break; + } + + if (r) { + if (q->result_head == r) + q->result_head = r->next; + else + last->next = r->next; + + if (q->result_tail == r) + q->result_tail = last; + + if (!q->result_head) + q->result_tail = NULL; + + q->next_serial++; + q->queue_len--; + } + + return r; +} + +/* + * Pulls a result off the head of the result queue. Caller should + * free it (and any internals as appropriate) after use. This doesn't + * wait for a result to be present. + * + * Results will be returned in strict order. + * + * Returns t_pool_result pointer if a result is ready. + * NULL if not. + */ +t_pool_result *t_pool_next_result(t_results_queue *q) { + t_pool_result *r; + +#ifdef DEBUG + fprintf(stderr, "Requesting next result on queue %p\n", q); +#endif + + pthread_mutex_lock(&q->result_m); + r = t_pool_next_result_locked(q); + pthread_mutex_unlock(&q->result_m); + +#ifdef DEBUG + fprintf(stderr, "(q=%p) Found %p\n", q, r); +#endif + + return r; +} + +t_pool_result *t_pool_next_result_wait(t_results_queue *q) { + t_pool_result *r; + +#ifdef DEBUG + fprintf(stderr, "Waiting for result %d...\n", q->next_serial); +#endif + + pthread_mutex_lock(&q->result_m); + while (!(r = t_pool_next_result_locked(q))) { + /* Possible race here now avoided via _locked() call, but incase... */ + struct timeval now; + struct timespec timeout; + + gettimeofday(&now, NULL); + timeout.tv_sec = now.tv_sec + 10; + timeout.tv_nsec = now.tv_usec * 1000; + + pthread_cond_timedwait(&q->result_avail_c, &q->result_m, &timeout); + } + pthread_mutex_unlock(&q->result_m); + + return r; +} + +/* + * Returns true if there are no items on the finished results queue and + * also none still pending. + */ +int t_pool_results_queue_empty(t_results_queue *q) { + int empty; + + pthread_mutex_lock(&q->result_m); + empty = q->queue_len == 0 && q->pending == 0; + pthread_mutex_unlock(&q->result_m); + + return empty; +} + + +/* + * Returns the number of completed jobs on the results queue. + */ +int t_pool_results_queue_len(t_results_queue *q) { + int len; + + pthread_mutex_lock(&q->result_m); + len = q->queue_len; + pthread_mutex_unlock(&q->result_m); + + return len; +} + +int t_pool_results_queue_sz(t_results_queue *q) { + int len; + + pthread_mutex_lock(&q->result_m); + len = q->queue_len + q->pending; + pthread_mutex_unlock(&q->result_m); + + return len; +} + +/* + * Frees a result 'r' and if free_data is true also frees + * the internal r->data result too. + */ +void t_pool_delete_result(t_pool_result *r, int free_data) { + if (!r) + return; + + if (free_data && r->data) + free(r->data); + + free(r); +} + +/* + * Initialises a results queue. + * + * Results queue pointer on success; + * NULL on failure + */ +t_results_queue *t_results_queue_init(void) { + t_results_queue *q = malloc(sizeof(*q)); + + pthread_mutex_init(&q->result_m, NULL); + pthread_cond_init(&q->result_avail_c, NULL); + + q->result_head = NULL; + q->result_tail = NULL; + q->next_serial = 0; + q->curr_serial = 0; + q->queue_len = 0; + q->pending = 0; + + return q; +} + +/* Deallocates memory for a results queue */ +void t_results_queue_destroy(t_results_queue *q) { +#ifdef DEBUG + fprintf(stderr, "Destroying results queue %p\n", q); +#endif + + if (!q) + return; + + pthread_mutex_destroy(&q->result_m); + pthread_cond_destroy(&q->result_avail_c); + + memset(q, 0xbb, sizeof(*q)); + free(q); + +#ifdef DEBUG + fprintf(stderr, "Destroyed results queue %p\n", q); +#endif +} + +/* ---------------------------------------------------------------------------- + * The thread pool. + */ + +#define TDIFF(t2,t1) ((t2.tv_sec-t1.tv_sec)*1000000 + t2.tv_usec-t1.tv_usec) + +/* + * A worker thread. + * + * Each thread waits for the pool to be non-empty. + * As soon as this applies, one of them succeeds in getting the lock + * and then executes the job. + */ +static void *t_pool_worker(void *arg) { + t_pool_worker_t *w = (t_pool_worker_t *)arg; + t_pool *p = w->p; + t_pool_job *j; +#ifdef DEBUG_TIME + struct timeval t1, t2, t3; +#endif + + for (;;) { + // Pop an item off the pool queue +#ifdef DEBUG_TIME + gettimeofday(&t1, NULL); +#endif + + pthread_mutex_lock(&p->pool_m); + +#ifdef DEBUG_TIME + gettimeofday(&t2, NULL); + p->wait_time += TDIFF(t2,t1); + w->wait_time += TDIFF(t2,t1); +#endif + + // If there is something on the job list and a higher priority + // thread waiting, let it handle this instead. +// while (p->head && p->t_stack_top != -1 && p->t_stack_top < w->idx) { +// pthread_mutex_unlock(&p->pool_m); +// pthread_cond_signal(&p->t[p->t_stack_top].pending_c); +// pthread_mutex_lock(&p->pool_m); +// } + + while (!p->head && !p->shutdown) { + p->nwaiting++; + + if (p->njobs == 0) + pthread_cond_signal(&p->empty_c); +#ifdef DEBUG_TIME + gettimeofday(&t2, NULL); +#endif + +#ifdef IN_ORDER + // Push this thread to the top of the waiting stack + if (p->t_stack_top == -1 || p->t_stack_top > w->idx) + p->t_stack_top = w->idx; + + p->t_stack[w->idx] = 1; + pthread_cond_wait(&w->pending_c, &p->pool_m); + p->t_stack[w->idx] = 0; + + /* Find new t_stack_top */ + { + int i; + p->t_stack_top = -1; + for (i = 0; i < p->tsize; i++) { + if (p->t_stack[i]) { + p->t_stack_top = i; + break; + } + } + } +#else + pthread_cond_wait(&p->pending_c, &p->pool_m); +#endif + +#ifdef DEBUG_TIME + gettimeofday(&t3, NULL); + p->wait_time += TDIFF(t3,t2); + w->wait_time += TDIFF(t3,t2); +#endif + p->nwaiting--; + } + + if (p->shutdown) { +#ifdef DEBUG_TIME + p->total_time += TDIFF(t3,t1); +#endif +#ifdef DEBUG + fprintf(stderr, "%d: Shutting down\n", worker_id(p)); +#endif + pthread_mutex_unlock(&p->pool_m); + pthread_exit(NULL); + } + + j = p->head; + if (!(p->head = j->next)) + p->tail = NULL; + + if (p->njobs-- >= p->qsize) + pthread_cond_signal(&p->full_c); + + if (p->njobs == 0) + pthread_cond_signal(&p->empty_c); + + pthread_mutex_unlock(&p->pool_m); + + // We have job 'j' - now execute it. + t_pool_add_result(j, j->func(j->arg)); +#ifdef DEBUG_TIME + pthread_mutex_lock(&p->pool_m); + gettimeofday(&t3, NULL); + p->total_time += TDIFF(t3,t1); + pthread_mutex_unlock(&p->pool_m); +#endif + memset(j, 0xbb, sizeof(*j)); + free(j); + } + + return NULL; +} + +/* + * Creates a worker pool of length qsize with tsize worker threads. + * + * Returns pool pointer on success; + * NULL on failure + */ +t_pool *t_pool_init(int qsize, int tsize) { + int i; + t_pool *p = malloc(sizeof(*p)); + p->qsize = qsize; + p->tsize = tsize; + p->njobs = 0; + p->nwaiting = 0; + p->shutdown = 0; + p->head = p->tail = NULL; + p->t_stack = NULL; +#ifdef DEBUG_TIME + p->total_time = p->wait_time = 0; +#endif + + p->t = malloc(tsize * sizeof(p->t[0])); + + pthread_mutex_init(&p->pool_m, NULL); + pthread_cond_init(&p->empty_c, NULL); + pthread_cond_init(&p->full_c, NULL); + + pthread_mutex_lock(&p->pool_m); + +#ifdef IN_ORDER + if (!(p->t_stack = malloc(tsize * sizeof(*p->t_stack)))) + return NULL; + p->t_stack_top = -1; + + for (i = 0; i < tsize; i++) { + t_pool_worker_t *w = &p->t[i]; + p->t_stack[i] = 0; + w->p = p; + w->idx = i; + w->wait_time = 0; + pthread_cond_init(&w->pending_c, NULL); + if (0 != pthread_create(&w->tid, NULL, t_pool_worker, w)) + return NULL; + } +#else + pthread_cond_init(&p->pending_c, NULL); + + for (i = 0; i < tsize; i++) { + t_pool_worker_t *w = &p->t[i]; + w->p = p; + w->idx = i; + pthread_cond_init(&w->pending_c, NULL); + if (0 != pthread_create(&w->tid, NULL, t_pool_worker, w)) + return NULL; + } +#endif + + pthread_mutex_unlock(&p->pool_m); + + return p; +} + +/* + * Adds an item to the work pool. + * + * FIXME: Maybe return 1,0,-1 and distinguish between job dispathed vs + * result returned. Ie rather than blocking on full queue we're permitted + * to return early on "result available" event too. + * Caller would then have a while loop around t_pool_dispatch. + * Or, return -1 and set errno to EAGAIN to indicate job not yet submitted. + * + * Returns 0 on success + * -1 on failure + */ +int t_pool_dispatch(t_pool *p, t_results_queue *q, + void *(*func)(void *arg), void *arg) { + t_pool_job *j = malloc(sizeof(*j)); + + if (!j) + return -1; + j->func = func; + j->arg = arg; + j->next = NULL; + j->p = p; + j->q = q; + if (q) { + pthread_mutex_lock(&q->result_m); + j->serial = q->curr_serial++; + q->pending++; + pthread_mutex_unlock(&q->result_m); + } else { + j->serial = 0; + } + +#ifdef DEBUG + fprintf(stderr, "Dispatching job %p for queue %p, serial %d\n", j, q, j->serial); +#endif + + pthread_mutex_lock(&p->pool_m); + + // Check if queue is full + while (p->njobs >= p->qsize) + pthread_cond_wait(&p->full_c, &p->pool_m); + + p->njobs++; + + if (p->tail) { + p->tail->next = j; + p->tail = j; + } else { + p->head = p->tail = j; + } + + // Let a worker know we have data. +#ifdef IN_ORDER + if (p->t_stack_top >= 0 && p->njobs > p->tsize - p->nwaiting) + pthread_cond_signal(&p->t[p->t_stack_top].pending_c); +#else + pthread_cond_signal(&p->pending_c); +#endif + pthread_mutex_unlock(&p->pool_m); + +#ifdef DEBUG + fprintf(stderr, "Dispatched (serial %d)\n", j->serial); +#endif + + return 0; +} + +/* + * As above but optional non-block flag. + * + * nonblock 0 => block if input queue is full + * nonblock +1 => don't block if input queue is full, but do not add task + * nonblock -1 => add task regardless of whether queue is full (over-size) + */ +int t_pool_dispatch2(t_pool *p, t_results_queue *q, + void *(*func)(void *arg), void *arg, int nonblock) { + t_pool_job *j; + +#ifdef DEBUG + fprintf(stderr, "Dispatching job for queue %p, serial %d\n", q, q->curr_serial); +#endif + + pthread_mutex_lock(&p->pool_m); + + if (p->njobs >= p->qsize && nonblock == 1) { + pthread_mutex_unlock(&p->pool_m); + errno = EAGAIN; + return -1; + } + + if (!(j = malloc(sizeof(*j)))) + return -1; + j->func = func; + j->arg = arg; + j->next = NULL; + j->p = p; + j->q = q; + if (q) { + pthread_mutex_lock(&q->result_m); + j->serial = q->curr_serial; + pthread_mutex_unlock(&q->result_m); + } else { + j->serial = 0; + } + + if (q) { + pthread_mutex_lock(&q->result_m); + q->curr_serial++; + q->pending++; + pthread_mutex_unlock(&q->result_m); + } + + // Check if queue is full + if (nonblock == 0) + while (p->njobs >= p->qsize) + pthread_cond_wait(&p->full_c, &p->pool_m); + + p->njobs++; + +// if (q->curr_serial % 100 == 0) +// fprintf(stderr, "p->njobs = %d p->qsize = %d\n", p->njobs, p->qsize); + + if (p->tail) { + p->tail->next = j; + p->tail = j; + } else { + p->head = p->tail = j; + } + +#ifdef DEBUG + fprintf(stderr, "Dispatched (serial %d)\n", j->serial); +#endif + + // Let a worker know we have data. +#ifdef IN_ORDER + // Keep incoming queue at 1 per running thread, so there is always + // something waiting when they end their current task. If we go above + // this signal to start more threads (if available). This has the effect + // of concentrating jobs to fewer cores when we are I/O bound, which in + // turn benefits systems with auto CPU frequency scaling. + if (p->t_stack_top >= 0 && p->njobs > p->tsize - p->nwaiting) + pthread_cond_signal(&p->t[p->t_stack_top].pending_c); +#else + pthread_cond_signal(&p->pending_c); +#endif + + pthread_mutex_unlock(&p->pool_m); + + return 0; +} + +/* + * Flushes the pool, but doesn't exit. This simply drains the queue and + * ensures all worker threads have finished their current task. + * + * Returns 0 on success; + * -1 on failure + */ +int t_pool_flush(t_pool *p) { + int i; + +#ifdef DEBUG + fprintf(stderr, "Flushing pool %p\n", p); +#endif + + // Drains the queue + pthread_mutex_lock(&p->pool_m); + + // Wake up everything for the final sprint! + for (i = 0; i < p->tsize; i++) + if (p->t_stack[i]) + pthread_cond_signal(&p->t[i].pending_c); + + while (p->njobs || p->nwaiting != p->tsize) + pthread_cond_wait(&p->empty_c, &p->pool_m); + + pthread_mutex_unlock(&p->pool_m); + +#ifdef DEBUG + fprintf(stderr, "Flushed complete for pool %p, njobs=%d, nwaiting=%d\n", + p, p->njobs, p->nwaiting); +#endif + + return 0; +} + +/* + * Destroys a thread pool. If 'kill' is true the threads are terminated now, + * otherwise they are joined into the main thread so they will finish their + * current work load. + * + * Use t_pool_destroy(p,0) after a t_pool_flush(p) on a normal shutdown or + * t_pool_destroy(p,1) to quickly exit after a fatal error. + */ +void t_pool_destroy(t_pool *p, int kill) { + int i; + +#ifdef DEBUG + fprintf(stderr, "Destroying pool %p, kill=%d\n", p, kill); +#endif + + /* Send shutdown message to worker threads */ + if (!kill) { + pthread_mutex_lock(&p->pool_m); + p->shutdown = 1; + +#ifdef DEBUG + fprintf(stderr, "Sending shutdown request\n"); +#endif + +#ifdef IN_ORDER + for (i = 0; i < p->tsize; i++) + pthread_cond_signal(&p->t[i].pending_c); +#else + pthread_cond_broadcast(&p->pending_c); +#endif + pthread_mutex_unlock(&p->pool_m); + +#ifdef DEBUG + fprintf(stderr, "Shutdown complete\n"); +#endif + for (i = 0; i < p->tsize; i++) + pthread_join(p->t[i].tid, NULL); + } else { + for (i = 0; i < p->tsize; i++) + pthread_kill(p->t[i].tid, SIGINT); + } + + pthread_mutex_destroy(&p->pool_m); + pthread_cond_destroy(&p->empty_c); + pthread_cond_destroy(&p->full_c); +#ifdef IN_ORDER + for (i = 0; i < p->tsize; i++) + pthread_cond_destroy(&p->t[i].pending_c); +#else + pthread_cond_destroy(&p->pending_c); +#endif + +#ifdef DEBUG_TIME + fprintf(stderr, "Total time=%f\n", p->total_time / 1000000.0); + fprintf(stderr, "Wait time=%f\n", p->wait_time / 1000000.0); + fprintf(stderr, "%d%% utilisation\n", + (int)(100 - ((100.0 * p->wait_time) / p->total_time + 0.5))); + for (i = 0; i < p->tsize; i++) + fprintf(stderr, "%d: Wait time=%f\n", i, + p->t[i].wait_time / 1000000.0); +#endif + + if (p->t_stack) + free(p->t_stack); + + free(p->t); + free(p); + +#ifdef DEBUG + fprintf(stderr, "Destroyed pool %p\n", p); +#endif +} + + +/*----------------------------------------------------------------------------- + * Test app. + */ + +#ifdef TEST_MAIN + +#include <stdio.h> +#include <math.h> + +void *doit(void *arg) { + int i, k, x = 0; + int job = *(int *)arg; + int *res; + + printf("Worker: execute job %d\n", job); + + usleep(random() % 1000000); // to coerce job completion out of order + if (0) { + for (k = 0; k < 100; k++) { + for (i = 0; i < 100000; i++) { + x++; + x += x * sin(i); + x += x * cos(x); + } + } + x *= 100; + x += job; + } else { + x = job*job; + } + + printf("Worker: job %d terminating, x=%d\n", job, x); + + free(arg); + + res = malloc(sizeof(*res)); + *res = x; + + return res; +} + +#define NTHREADS 8 + +int main(int argc, char **argv) { + t_pool *p = t_pool_init(NTHREADS*2, NTHREADS); + t_results_queue *q = t_results_queue_init(); + int i; + t_pool_result *r; + + // Dispatch jobs + for (i = 0; i < 20; i++) { + int *ip = malloc(sizeof(*ip)); + *ip = i; + printf("Submitting %d\n", i); + t_pool_dispatch(p, q, doit, ip); + + // Check for results + if ((r = t_pool_next_result(q))) { + printf("RESULT: %d\n", *(int *)r->data); + t_pool_delete_result(r, 1); + } + } + + t_pool_flush(p); + + while ((r = t_pool_next_result(q))) { + printf("RESULT: %d\n", *(int *)r->data); + t_pool_delete_result(r, 1); + } + + t_pool_destroy(p, 0); + t_results_queue_destroy(q); + + return 0; +} +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/thread_pool.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,210 @@ +/* +Copyright (c) 2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +/* + * This file implements a thread pool for multi-threading applications. + * It consists of two distinct interfaces: thread pools an results queues. + * + * The pool of threads is given a function pointer and void* data to pass in. + * This means the pool can run jobs of multiple types, albeit first come + * first served with no job scheduling. + * + * Upon completion, the return value from the function pointer is added to + * a results queue. We may have multiple queues in use for the one pool. + * + * An example: reading from BAM and writing to CRAM with 10 threads. We'll + * have a pool of 10 threads and two results queues holding decoded BAM blocks + * and encoded CRAM blocks respectively. + */ + +#ifndef _THREAD_POOL_H_ +#define _THREAD_POOL_H_ + +#include <pthread.h> + +struct t_pool; +struct t_results_queue; + +typedef struct t_pool_job { + void *(*func)(void *arg); + void *arg; + struct t_pool_job *next; + + struct t_pool *p; + struct t_results_queue *q; + int serial; +} t_pool_job; + +typedef struct t_res { + struct t_res *next; + int serial; // sequential number for ordering + void *data; // result itself +} t_pool_result; + +struct t_pool; + +typedef struct { + struct t_pool *p; + int idx; + pthread_t tid; + pthread_cond_t pending_c; + long long wait_time; +} t_pool_worker_t; + +typedef struct t_pool { + int qsize; // size of queue + int njobs; // pending job count + int nwaiting; // how many workers waiting for new jobs + int shutdown; // true if pool is being destroyed + + // queue of pending jobs + t_pool_job *head, *tail; + + // threads + int tsize; // maximum number of jobs + t_pool_worker_t *t; + + // Mutexes + pthread_mutex_t pool_m; // used when updating head/tail + + pthread_cond_t empty_c; + pthread_cond_t pending_c; // not empty + pthread_cond_t full_c; + + // array of worker IDs free + int *t_stack, t_stack_top; + + // Debugging to check wait time + long long total_time, wait_time; +} t_pool; + +typedef struct t_results_queue { + t_pool_result *result_head; + t_pool_result *result_tail; + int next_serial; + int curr_serial; + int queue_len; // number of items in queue + int pending; // number of pending items (in progress or in pool list) + pthread_mutex_t result_m; + pthread_cond_t result_avail_c; +} t_results_queue; + + +/* + * Creates a worker pool of length qsize with tsize worker threads. + * + * Returns pool pointer on success; + * NULL on failure + */ +t_pool *t_pool_init(int qsize, int tsize); + +/* + * Adds an item to the work pool. + * + * FIXME: Maybe return 1,0,-1 and distinguish between job dispathed vs + * result returned. Ie rather than blocking on full queue we're permitted + * to return early on "result available" event too. + * Caller would then have a while loop around t_pool_dispatch. + * Or, return -1 and set errno to E_AGAIN to indicate job not yet submitted. + * + * Returns 0 on success + * -1 on failure + */ +int t_pool_dispatch(t_pool *p, t_results_queue *q, + void *(*func)(void *arg), void *arg); +int t_pool_dispatch2(t_pool *p, t_results_queue *q, + void *(*func)(void *arg), void *arg, int nonblock); + +/* + * Flushes the pool, but doesn't exit. This simply drains the queue and + * ensures all worker threads have finished their current task. + * + * Returns 0 on success; + * -1 on failure + */ +int t_pool_flush(t_pool *p); + +/* + * Destroys a thread pool. If 'kill' is true the threads are terminated now, + * otherwise they are joined into the main thread so they will finish their + * current work load. + * + * Use t_pool_destroy(p,0) after a t_pool_flush(p) on a normal shutdown or + * t_pool_destroy(p,1) to quickly exit after a fatal error. + */ +void t_pool_destroy(t_pool *p, int kill); + +/* + * Pulls a result off the head of the result queue. Caller should + * free it (and any internals as appropriate) after use. This doesn't + * wait for a result to be present. + * + * Results will be returned in strict order. + * + * Returns t_pool_result pointer if a result is ready. + * NULL if not. + */ +t_pool_result *t_pool_next_result(t_results_queue *q); +t_pool_result *t_pool_next_result_wait(t_results_queue *q); + +/* + * Frees a result 'r' and if free_data is true also frees + * the internal r->data result too. + */ +void t_pool_delete_result(t_pool_result *r, int free_data); + +/* + * Initialises a results queue. + * + * Results queue pointer on success; + * NULL on failure + */ +t_results_queue *t_results_queue_init(void); + +/* Deallocates memory for a results queue */ +void t_results_queue_destroy(t_results_queue *q); + +/* + * Returns true if there are no items on the finished results queue and + * also none still pending. + */ +int t_pool_results_queue_empty(t_results_queue *q); + +/* + * Returns the number of completed jobs on the results queue. + */ +int t_pool_results_queue_len(t_results_queue *q); + +/* + * Returns the number of completed jobs plus the number queued up to run. + */ +int t_pool_results_queue_sz(t_results_queue *q); + +#endif /* _THREAD_POOL_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/vlen.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,432 @@ +/* +Author: James Bonfield (jkb@sanger.ac.uk) + +Copyright (c) 1995-1996 MEDICAL RESEARCH COUNCIL +All rights reserved + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1 Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2 Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3 Neither the name of the MEDICAL RESEARCH COUNCIL, THE LABORATORY OF +MOLECULAR BIOLOGY nor the names of its contributors may be used to endorse or +promote products derived from this software without specific prior written +permission. + +THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR +ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES +(INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; +LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON +ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT +(INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS +SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. + */ + +/* +Copyright (c) 2004, 2009, 2011-2012 Genome Research Ltd. + +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdio.h> +#include <stdlib.h> +#include <stdarg.h> +#include <sys/types.h> +#include <string.h> + +#include "cram/vlen.h" +#include "cram/os.h" + +#ifndef MAX +#define MAX(a,b) ((a)>(b)?(a):(b)) +#endif + +#ifndef ABS +#define ABS(a) ((a)>0?(a):-(a)) +#endif + +/* #define DEBUG_printf(a,n) printf(a,n) */ +#define DEBUG_printf(a,n) + +/* + * vlen: 27/10/95 written by James Bonfield, jkb@mrc-lmb.cam.ac.uk + * + * Given sprintf style of arguments this routine returns the maximum + * size of buffer needed to allocate to use with sprintf. It errs on + * the side of caution by being simplistic in its approach: we assume + * all numbers are of maximum length. + * + * Handles the usual type conversions (%[%diuaxXcfeEgGpns]), but not + * the 'wide' character conversions (%C and %S). + * Precision is handled in the correct formats, including %*.* + * notations. + * Additionally, some of the more dubious (but probably illegal) cases + * are supported (eg "%10%" will expand to " %" on many + * systems). + * + * We also assume that the largest integer and larger pointer are 64 + * bits, which at least covers the machines we'll need it for. + */ +int flen(char *fmt, ...) +{ + va_list args; + + va_start(args, fmt); + return vflen(fmt, args); +} + +int vflen(char *fmt, va_list ap) +{ + int len = 0; + char *cp, c; + long long l; + int i; + double d; + + /* + * This code modifies 'ap', but we do not know if va_list is a structure + * or a pointer to an array so we do not know if it is a local variable + * or not. + * C99 gets around this by defining va_copy() to make copies of ap, but + * this does not exist on all systems. + * For now, I just assume that when va_list is a pointer the system also + * provides a va_copy macro to work around this problem. The only system + * I have seen needing this so far was Linux on AMD64. + */ +#if defined(HAVE_VA_COPY) + va_list ap_local; + va_copy(ap_local, ap); +# define ap ap_local +#endif + + for(cp = fmt; *cp; cp++) { + switch(*cp) { + + /* A format specifier */ + case '%': { + char *endp; + long conv_len1=0, conv_len2=0, conv_len=0; + signed int arg_size; + + /* Firstly, strip the modifier flags (+-#0 and [space]) */ + for(; (c=*++cp);) { + if ('#' == c) + len+=2; /* Worst case of "0x" */ + else if ('-' == c || '+' == c || ' ' == c) + len++; + else + break; + } + + /* Width specifier */ + l = strtol(cp, &endp, 10); + if (endp != cp) { + cp = endp; + conv_len = conv_len1 = l; + } else if (*cp == '*') { + conv_len = conv_len1 = (int)va_arg(ap, int); + cp++; + } + + /* Precision specifier */ + if ('.' == *cp) { + cp++; + conv_len2 = strtol(cp, &endp, 10); + if (endp != cp) { + cp = endp; + } else if (*cp == '*') { + conv_len2 = (int)va_arg(ap, int); + cp++; + } + conv_len = MAX(conv_len1, conv_len2); + } + + /* Short/long identifier */ + if ('h' == *cp) { + arg_size = -1; /* short */ + cp++; + } else if ('l' == *cp) { + arg_size = 1; /* long */ + cp++; + if ('l' == *cp) { + arg_size = 2; /* long long */ + cp++; + } + } else { + arg_size = 0; /* int */ + } + + /* The actual type */ + switch (*cp) { + case '%': + /* + * Not real ANSI I suspect, but we'll allow for the + * completely daft "%10%" example. + */ + len += MAX(conv_len1, 1); + break; + + case 'd': + case 'i': + case 'u': + case 'a': + case 'x': + case 'X': + /* Remember: char and short are sent as int on the stack */ + if (arg_size == -1) + l = (long)va_arg(ap, int); + else if (arg_size == 1) + l = va_arg(ap, long); + else if (arg_size == 2) + l = va_arg(ap, long long); + else + l = (long)va_arg(ap, int); + + DEBUG_printf("%d", l); + + /* + * No number can be more than 24 characters so we'll take + * the max of conv_len and 24 (23 is len(2^64) in octal). + * All that work above and we then go and estimate ;-), + * but it's needed incase someone does %500d. + */ + len += MAX(conv_len, 23); + break; + + case 'c': + i = va_arg(ap, int); + DEBUG_printf("%c", i); + /* + * Note that %10c and %.10c act differently. + * Besides, I think precision is not really allowed for %c. + */ + len += MAX(conv_len1, i>=0x80 ?MB_CUR_MAX :1); + break; + + case 'f': + d = va_arg(ap, double); + DEBUG_printf("%f", d); + /* + * Maybe "Inf" or "NaN", but we'll not worry about that. + * Again, err on side of caution and take max of conv_len + * and max length of a double. The worst case I can + * think of is 317 characters (-1[308 zeros].000000) + * without using precision codes. That's horrid. I + * cheat and either use 317 or 15 depending on how + * large the number is as I reckon 99% of floats + * aren't that long. + */ + l = (ABS(d) > 1000000) ? 317 : 15; + l = MAX(l, conv_len1 + 2); + if (conv_len2) l += conv_len2 - 6; + len += l; + break; + + case 'e': + case 'E': + case 'g': + case 'G': + d = va_arg(ap, double); + DEBUG_printf("%g", d); + /* + * Maybe "Inf" or "NaN", but we'll not worry about that + * Again, err on side of caution and take max of conv_len + * and max length of a double (which defaults to only + * '-' + 6 + '.' + 'E[+-]xxx' == 13. + */ + len += MAX(conv_len, 13); + break; + + case 'p': + l = (long)va_arg(ap, void *); + /* + * Max pointer is 64bits == 16 chars (on alpha), + * == 20 with + "0x". + */ + DEBUG_printf("%p", (void *)l); + len += MAX(conv_len, 20); + break; + + case 'n': + /* produces no output */ + break; + + case 's': { + char *s = (char *)va_arg(ap, char *); + DEBUG_printf("%s", s); + + if (!conv_len2) { + len += MAX(conv_len, (int)strlen(s)); + } else { + len += conv_len; + } + break; + } + + default: + /* wchar_t types of 'C' and 'S' aren't supported */ + DEBUG_printf("Arg is %c\n", *cp); + } + + } + + case '\0': + break; + + default: + DEBUG_printf("%c", *cp); + len++; + } + } + + va_end(ap); + + return len+1; /* one for the null character */ +} + +#if 0 +int main() { + int l; + char buf[10000]; + + sprintf(buf, "d: %d\n", 500); + l = flen("d: %d\n", 500); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, ""); + l = flen(""); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%s\n","test"); + l = flen("%s\n", "test"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%c\n", 'a'); + l = flen("%c\n", 'a'); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%31.30f\n", -9999.99); + l = flen("%31.30f\n", -9999.99); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%f\n", -1e308); + l = flen("%f\n", -1e308); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%.9f\n", -1e308); + l = flen("%.9f\n", -1e308); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%10.20f\n", -1.999222333); + l = flen("%10.20f\n", -1.999222333); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%#g\n", -3.14159265358e-222); + l = flen("%#g\n", -3.1415927e-222); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%e\n", -123456789123456789.1); + l = flen("%e\n", -123456789123456789.1); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%c %f %d %s %c %g %ld %s\n", 'a', 3.1, 9, "one", 'b', 4.2, 9, "two"); + l = flen("%c %f %d %s %c %g %ld %s\n", 'a', 3.1, 9, "one", 'b', 4.2, 9, "two"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%*.*e %*c\n", 10, 5, 9.0, 20, 'x'); + l = flen("%*.*e %*c\n", 10, 5, 9.0, 20, 'x'); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%10c\n", 'z'); + l = flen("%10c\n", 'z'); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%.10c\n", 'z'); + l = flen("%.10c\n", 'z'); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%10d\n", 'z'); + l = flen("%10d\n", 'z'); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%.10d\n", 'z'); + l = flen("%.10d\n", 'z'); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%10%\n"); + l = flen("%10%\n"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%.10%\n"); + l = flen("%.10%\n"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%s\n", "0123456789"); + l = flen("%s\n", "0123456789"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%5s\n", "0123456789"); + l = flen("%5s\n", "0123456789"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%50s\n", "0123456789"); + l = flen("%50s\n", "0123456789"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%.5s\n", "0123456789"); + l = flen("%.5s\n", "0123456789"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%.50s\n", "0123456789"); + l = flen("%.50s\n", "0123456789"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%5.50s\n", "0123456789"); + l = flen("%5.50s\n", "0123456789"); + printf("%d %d\n\n", strlen(buf), l); + + sprintf(buf, "%50.5s\n", "0123456789"); + l = flen("%50.5s\n", "0123456789"); + printf("%d %d\n\n", strlen(buf), l); + + return 0; +} +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/vlen.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,48 @@ +/* +Author: James Bonfield (jkb@sanger.ac.uk) + +Copyright (c) 1995-1996 MEDICAL RESEARCH COUNCIL +All rights reserved + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1 Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2 Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3 Neither the name of the MEDICAL RESEARCH COUNCIL, THE LABORATORY OF +MOLECULAR BIOLOGY nor the names of its contributors may be used to endorse or +promote products derived from this software without specific prior written +permission. + +THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR +ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES +(INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; +LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON +ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT +(INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS +SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _VLEN_H_ +#define _VLEN_H_ + +#ifdef __cplusplus +extern "C" { +#endif + +extern int vflen(char *fmt, va_list ap); +extern int flen(char *fmt, ...); + +#ifdef __cplusplus +} +#endif + +#endif /* _VLEN_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/zfio.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,185 @@ +/* +Copyright (c) 2009-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifdef HAVE_CONFIG_H +#include "io_lib_config.h" +#endif + +#include <stdlib.h> +#include <unistd.h> + +#include "cram/os.h" +#include "cram/zfio.h" + +/* ------------------------------------------------------------------------ */ +/* Some wrappers around FILE * vs gzFile *, allowing for either */ + +/* + * gzopen() works on both compressed and uncompressed data, but it has + * a significant performance hit even for uncompressed data (tested as + * 25s using FILE* to 46s via gzOpen and 66s via gzOpen when gzipped). + * + * Hence we use our own wrapper 'zfp' which is a FILE* when uncompressed + * and gzFile* when compressed. This also means we could hide bzopen in + * there too if desired. + */ + +off_t zftello(zfp *zf) { + return zf->fp ? ftello(zf->fp) : -1; +} + +int zfseeko(zfp *zf, off_t offset, int whence) { + return zf->fp ? fseeko(zf->fp, offset, whence) : -1; +} + + +/* + * A wrapper for either fgets or gzgets depending on what has been + * opened. + */ +char *zfgets(char *line, int size, zfp *zf) { + if (zf->fp) + return fgets(line, size, zf->fp); + else + return gzgets(zf->gz, line, size); +} + +/* + * A wrapper for either fputs or gzputs depending on what has been + * opened. + */ +int zfputs(char *line, zfp *zf) { + if (zf->fp) + return fputs(line, zf->fp); + else + return gzputs(zf->gz, line) ? 0 : EOF; +} + +/* + * Peeks at and returns the next character without consuming it from the + * input. (Ie a combination of getc and ungetc). + */ +int zfpeek(zfp *zf) { + int c; + + if (zf->fp) { + c = getc(zf->fp); + if (c != EOF) + ungetc(c, zf->fp); + } else { + c = gzgetc(zf->gz); + if (c != EOF) + gzungetc(c, zf->gz); + } + + return c; +} + +/* A replacement for either feof of gzeof */ +int zfeof(zfp *zf) { + return zf->fp ? feof(zf->fp) : gzeof(zf->gz); +} + +/* A replacement for either fopen or gzopen */ +zfp *zfopen(const char *path, const char *mode) { + char path2[1024]; + zfp *zf; + + if (!(zf = (zfp *)malloc(sizeof(*zf)))) + return NULL; + zf->fp = NULL; + zf->gz = NULL; + + /* Try normal fopen */ + if (mode[0] != 'z' && mode[1] != 'z' && + NULL != (zf->fp = fopen(path, mode))) { + unsigned char magic[2]; + if (2 != fread(magic, 1, 2, zf->fp)) { + free(zf); + return NULL; + } + if (!(magic[0] == 0x1f && + magic[1] == 0x8b)) { + fseeko(zf->fp, 0, SEEK_SET); + return zf; + } + + fclose(zf->fp); + zf->fp = NULL; + } + +#ifdef HAVE_POPEN + /* + * I've no idea why, by gzgets is VERY slow, maybe because it handles + * arbitrary seeks. + * popen to gzip -cd is 3 times faster though. + */ + if (*mode == 'w') { + } else { + if (access(path, R_OK) == 0) { + sprintf(path2, "gzip -cd < %.*s", 1000, path); + if (NULL != (zf->fp = popen(path2, "r"))) + return zf; + } + + sprintf(path2, "gzip -cd < %.*s.gz", 1000, path); + if (NULL != (zf->fp = popen(path2, "r"))) + return zf; + + printf("Failed on %s\n", path); + } else { + sprintf(path2, "gzip > %.*s", 1000, path); + if (NULL != (zf->fp = popen(path2, "w"))) + return zf; + } + + printf("Failed on %s\n", path); + } +#else + /* Gzopen instead */ + if ((zf->gz = gzopen(path, mode))) + return zf; + + sprintf(path2, "%.*s.gz", 1020, path); + if ((zf->gz = gzopen(path2, mode))) + return zf; +#endif + + perror(path); + + free(zf); + return NULL; +} + +int zfclose(zfp *zf) { + int r = (zf->fp) ? fclose(zf->fp) : gzclose(zf->gz); + free(zf); + return r; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/cram/zfio.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,54 @@ +/* +Copyright (c) 2009-2013 Genome Research Ltd. +Author: James Bonfield <jkb@sanger.ac.uk> + +Redistribution and use in source and binary forms, with or without +modification, are permitted provided that the following conditions are met: + + 1. Redistributions of source code must retain the above copyright notice, +this list of conditions and the following disclaimer. + + 2. Redistributions in binary form must reproduce the above copyright notice, +this list of conditions and the following disclaimer in the documentation +and/or other materials provided with the distribution. + + 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger +Institute nor the names of its contributors may be used to endorse or promote +products derived from this software without specific prior written permission. + +THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS IS" AND +ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED +WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE +DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH LTD OR CONTRIBUTORS BE LIABLE +FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL +DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR +SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER +CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, +OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE +OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. +*/ + +#ifndef _ZFIO_H_ +#define _ZFIO_H_ + +#include <stdio.h> +#include <zlib.h> + +/* + * Either a gzFile or a FILE. + */ +typedef struct { + FILE *fp; + gzFile gz; +} zfp; + +off_t zftello(zfp *zf); +int zfseeko(zfp *zf, off_t offset, int whence); +char *zfgets(char *line, int size, zfp *zf); +int zfputs(char *line, zfp *zf); +zfp *zfopen(const char *path, const char *mode); +int zfclose(zfp *zf); +int zfpeek(zfp *zf); +int zfeof(zfp *zf); + +#endif /* _ZFIO_H_ */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/faidx.5 Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,147 @@ +'\" t +.TH faidx 5 "August 2013" "htslib" "Bioinformatics formats" +.SH NAME +faidx \- an index enabling random access to FASTA files +.\" +.\" Copyright (C) 2013 Genome Research Ltd. +.\" +.\" Author: John Marshall <jm18@sanger.ac.uk> +.\" +.\" Permission is hereby granted, free of charge, to any person obtaining a +.\" copy of this software and associated documentation files (the "Software"), +.\" to deal in the Software without restriction, including without limitation +.\" the rights to use, copy, modify, merge, publish, distribute, sublicense, +.\" and/or sell copies of the Software, and to permit persons to whom the +.\" Software is furnished to do so, subject to the following conditions: +.\" +.\" The above copyright notice and this permission notice shall be included in +.\" all copies or substantial portions of the Software. +.\" +.\" THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +.\" IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +.\" FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +.\" THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +.\" LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +.\" FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +.\" DEALINGS IN THE SOFTWARE. +.\" +.SH SYNOPSIS +.IR file.fa .fai, +.IR file.fasta .fai +.SH DESCRIPTION +Using an \fBfai index\fP file in conjunction with a FASTA file containing +reference sequences enables efficient access to arbitrary regions within +those reference sequences. +The index file typically has the same filename as the corresponding FASTA +file, with \fB.fai\fP appended. +.P +An \fBfai index\fP file is a text file consisting of lines each with +five TAB-delimited columns: +.TS +lbl. +NAME Name of this reference sequence +LENGTH Total length of this reference sequence, in bases +OFFSET Offset within the FASTA file of this sequence's first base +LINEBASES The number of bases on each line +LINEWIDTH The number of bytes in each line, including the newline +.TE +.P +The \fBNAME\fP and \fBLENGTH\fP columns contain the same +data as would appear in the \fBSN\fP and \fBLN\fP fields of a +SAM \fB@SQ\fP header for the same reference sequence. +.P +The \fBOFFSET\fP column contains the offset within the FASTA file, in bytes +starting from zero, of the first base of this reference sequence, i.e., of +the character following the newline at the end of the "\fB>\fP" header line. +Typically the lines of a \fBfai index\fP file appear in the order in which the +reference sequences appear in the FASTA file, so \fB.fai\fP files are typically +sorted according to this column. +.P +The \fBLINEBASES\fP column contains the number of bases in each of the sequence +lines that form the body of this reference sequence, apart from the final line +which may be shorter. +The \fBLINEWIDTH\fP column contains the number of \fIbytes\fP in each of +the sequence lines (except perhaps the final line), thus differing from +\fBLINEBASES\fP in that it also counts the bytes forming the line terminator. +.SS FASTA Files +In order to be indexed with \fBsamtools faidx\fP, a FASTA file must be a text +file of the form +.LP +.RS +.RI > name +.RI [ description ...] +.br +ATGCATGCATGCATGCATGCATGCATGCAT +.br +GCATGCATGCATGCATGCATGCATGCATGC +.br +ATGCAT +.br +.RI > name +.RI [ description ...] +.br +ATGCATGCATGCAT +.br +GCATGCATGCATGC +.br +[...] +.RE +.LP +In particular, each reference sequence must be "well-formatted", i.e., all +of its sequence lines must be the same length, apart from the final sequence +line which may be shorter. +(While this sequence line length must be the same within each sequence, +it may vary between different reference sequences in the same FASTA file.) +.P +This also means that although the FASTA file may have Unix- or Windows-style +or other line termination, the newline characters present must be consistent, +at least within each reference sequence. +.P +The \fBsamtools\fP implementation uses the first word of the "\fB>\fP" header +line text (i.e., up to the first whitespace character) as the \fBNAME\fP column. +At present, there may be no whitespace between the +">" character and the \fIname\fP. +.SH EXAMPLE +For example, given this FASTA file +.LP +.RS +>one +.br +ATGCATGCATGCATGCATGCATGCATGCAT +.br +GCATGCATGCATGCATGCATGCATGCATGC +.br +ATGCAT +.br +>two another chromosome +.br +ATGCATGCATGCAT +.br +GCATGCATGCATGC +.br +.RE +.LP +formatted with Unix-style (LF) line termination, the corresponding fai index +would be +.RS +.TS +lnnnn. +one 66 5 30 31 +two 28 98 14 15 +.TE +.RE +.LP +If the FASTA file were formatted with Windows-style (CR-LF) line termination, +the fai index would be +.RS +.TS +lnnnn. +one 66 6 30 32 +two 28 103 14 16 +.TE +.RE +.SH SEE ALSO +.IR samtools (1) +.TP +http://en.wikipedia.org/wiki/FASTA_format +Further description of the FASTA format
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/faidx.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,475 @@ +/* faidx.c -- FASTA random access. + + Copyright (C) 2008, 2009, 2013-2015 Genome Research Ltd. + Portions copyright (C) 2011 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <ctype.h> +#include <string.h> +#include <stdlib.h> +#include <stdio.h> +#include <stdint.h> + +#include "htslib/bgzf.h" +#include "htslib/faidx.h" +#include "htslib/hfile.h" +#include "htslib/khash.h" + +typedef struct { + int32_t line_len, line_blen; + int64_t len; + uint64_t offset; +} faidx1_t; +KHASH_MAP_INIT_STR(s, faidx1_t) + +struct __faidx_t { + BGZF *bgzf; + int n, m; + char **name; + khash_t(s) *hash; +}; + +#ifndef kroundup32 +#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x)) +#endif + +static inline void fai_insert_index(faidx_t *idx, const char *name, int len, int line_len, int line_blen, uint64_t offset) +{ + khint_t k; + int ret; + faidx1_t t; + if (idx->n == idx->m) { + idx->m = idx->m? idx->m<<1 : 16; + idx->name = (char**)realloc(idx->name, sizeof(char*) * idx->m); + } + idx->name[idx->n] = strdup(name); + k = kh_put(s, idx->hash, idx->name[idx->n], &ret); + t.len = len; t.line_len = line_len; t.line_blen = line_blen; t.offset = offset; + kh_value(idx->hash, k) = t; + ++idx->n; +} + +faidx_t *fai_build_core(BGZF *bgzf) +{ + char *name; + int c; + int l_name, m_name; + int line_len, line_blen, state; + int l1, l2; + faidx_t *idx; + uint64_t offset; + int64_t len; + + idx = (faidx_t*)calloc(1, sizeof(faidx_t)); + idx->hash = kh_init(s); + name = 0; l_name = m_name = 0; + len = line_len = line_blen = -1; state = 0; l1 = l2 = -1; offset = 0; + while ( (c=bgzf_getc(bgzf))>=0 ) { + if (c == '\n') { // an empty line + if (state == 1) { + offset = bgzf_utell(bgzf); + continue; + } else if ((state == 0 && len < 0) || state == 2) continue; + } + if (c == '>') { // fasta header + if (len >= 0) + fai_insert_index(idx, name, len, line_len, line_blen, offset); + l_name = 0; + while ( (c=bgzf_getc(bgzf))>=0 && !isspace(c)) { + if (m_name < l_name + 2) { + m_name = l_name + 2; + kroundup32(m_name); + name = (char*)realloc(name, m_name); + } + name[l_name++] = c; + } + name[l_name] = '\0'; + if ( c<0 ) { + fprintf(stderr, "[fai_build_core] the last entry has no sequence\n"); + free(name); fai_destroy(idx); + return 0; + } + if (c != '\n') while ( (c=bgzf_getc(bgzf))>=0 && c != '\n'); + state = 1; len = 0; + offset = bgzf_utell(bgzf); + } else { + if (state == 3) { + fprintf(stderr, "[fai_build_core] inlined empty line is not allowed in sequence '%s'.\n", name); + free(name); fai_destroy(idx); + return 0; + } + if (state == 2) state = 3; + l1 = l2 = 0; + do { + ++l1; + if (isgraph(c)) ++l2; + } while ( (c=bgzf_getc(bgzf))>=0 && c != '\n'); + if (state == 3 && l2) { + fprintf(stderr, "[fai_build_core] different line length in sequence '%s'.\n", name); + free(name); fai_destroy(idx); + return 0; + } + ++l1; len += l2; + if (state == 1) line_len = l1, line_blen = l2, state = 0; + else if (state == 0) { + if (l1 != line_len || l2 != line_blen) state = 2; + } + } + } + if ( name ) + fai_insert_index(idx, name, len, line_len, line_blen, offset); + else + { + free(idx); + return NULL; + } + free(name); + return idx; +} + +void fai_save(const faidx_t *fai, FILE *fp) +{ + khint_t k; + int i; + for (i = 0; i < fai->n; ++i) { + faidx1_t x; + k = kh_get(s, fai->hash, fai->name[i]); + x = kh_value(fai->hash, k); +#ifdef _WIN32 + fprintf(fp, "%s\t%d\t%ld\t%d\t%d\n", fai->name[i], (int)x.len, (long)x.offset, (int)x.line_blen, (int)x.line_len); +#else + fprintf(fp, "%s\t%d\t%lld\t%d\t%d\n", fai->name[i], (int)x.len, (long long)x.offset, (int)x.line_blen, (int)x.line_len); +#endif + } +} + +faidx_t *fai_read(FILE *fp) +{ + faidx_t *fai; + char *buf, *p; + int len, line_len, line_blen; +#ifdef _WIN32 + long offset; +#else + long long offset; +#endif + fai = (faidx_t*)calloc(1, sizeof(faidx_t)); + fai->hash = kh_init(s); + buf = (char*)calloc(0x10000, 1); + while (!feof(fp) && fgets(buf, 0x10000, fp)) { + for (p = buf; *p && isgraph(*p); ++p); + *p = 0; ++p; +#ifdef _WIN32 + sscanf(p, "%d%ld%d%d", &len, &offset, &line_blen, &line_len); +#else + sscanf(p, "%d%lld%d%d", &len, &offset, &line_blen, &line_len); +#endif + fai_insert_index(fai, buf, len, line_len, line_blen, offset); + } + free(buf); + return fai; +} + +void fai_destroy(faidx_t *fai) +{ + int i; + for (i = 0; i < fai->n; ++i) free(fai->name[i]); + free(fai->name); + kh_destroy(s, fai->hash); + if (fai->bgzf) bgzf_close(fai->bgzf); + free(fai); +} + +int fai_build(const char *fn) +{ + char *str; + BGZF *bgzf; + FILE *fp; + faidx_t *fai; + str = (char*)calloc(strlen(fn) + 5, 1); + sprintf(str, "%s.fai", fn); + bgzf = bgzf_open(fn, "r"); + if ( !bgzf ) { + fprintf(stderr, "[fai_build] fail to open the FASTA file %s\n",fn); + free(str); + return -1; + } + if ( bgzf->is_compressed ) bgzf_index_build_init(bgzf); + fai = fai_build_core(bgzf); + if ( !fai ) + { + if ( bgzf->is_compressed && bgzf->is_gzip ) fprintf(stderr,"Cannot index files compressed with gzip, please use bgzip\n"); + free(str); + return -1; + } + if ( bgzf->is_compressed ) bgzf_index_dump(bgzf, fn, ".gzi"); + bgzf_close(bgzf); + fp = fopen(str, "wb"); + if ( !fp ) { + fprintf(stderr, "[fai_build] fail to write FASTA index %s\n",str); + fai_destroy(fai); free(str); + return -1; + } + fai_save(fai, fp); + fclose(fp); + free(str); + fai_destroy(fai); + return 0; +} + +static FILE *download_and_open(const char *fn) +{ + const int buf_size = 1 * 1024 * 1024; + uint8_t *buf; + FILE *fp; + hFILE *fp_remote; + const char *url = fn; + const char *p; + int l = strlen(fn); + for (p = fn + l - 1; p >= fn; --p) + if (*p == '/') break; + fn = p + 1; + + // First try to open a local copy + fp = fopen(fn, "r"); + if (fp) + return fp; + + // If failed, download from remote and open + fp_remote = hopen(url, "rb"); + if (fp_remote == 0) { + fprintf(stderr, "[download_from_remote] fail to open remote file %s\n",url); + return NULL; + } + if ((fp = fopen(fn, "wb")) == 0) { + fprintf(stderr, "[download_from_remote] fail to create file in the working directory %s\n",fn); + hclose_abruptly(fp_remote); + return NULL; + } + buf = (uint8_t*)calloc(buf_size, 1); + while ((l = hread(fp_remote, buf, buf_size)) > 0) + fwrite(buf, 1, l, fp); + free(buf); + fclose(fp); + if (hclose(fp_remote) != 0) + fprintf(stderr, "[download_from_remote] fail to close remote file %s\n", url); + + return fopen(fn, "r"); +} + +faidx_t *fai_load(const char *fn) +{ + char *str; + FILE *fp; + faidx_t *fai; + str = (char*)calloc(strlen(fn) + 5, 1); + sprintf(str, "%s.fai", fn); + + if (hisremote(str)) + { + fp = download_and_open(str); + if ( !fp ) + { + fprintf(stderr, "[fai_load] failed to open remote FASTA index %s\n", str); + free(str); + return 0; + } + } + else + fp = fopen(str, "rb"); + + if (fp == 0) { + fprintf(stderr, "[fai_load] build FASTA index.\n"); + fai_build(fn); + fp = fopen(str, "rb"); + if (fp == 0) { + fprintf(stderr, "[fai_load] fail to open FASTA index.\n"); + free(str); + return 0; + } + } + + fai = fai_read(fp); + fclose(fp); + + fai->bgzf = bgzf_open(fn, "rb"); + free(str); + if (fai->bgzf == 0) { + fprintf(stderr, "[fai_load] fail to open FASTA file.\n"); + return 0; + } + if ( fai->bgzf->is_compressed==1 ) + { + if ( bgzf_index_load(fai->bgzf, fn, ".gzi") < 0 ) + { + fprintf(stderr, "[fai_load] failed to load .gzi index: %s[.gzi]\n", fn); + fai_destroy(fai); + return NULL; + } + } + return fai; +} + +char *fai_fetch(const faidx_t *fai, const char *str, int *len) +{ + char *s; + int c, i, l, k, name_end; + khiter_t iter; + faidx1_t val; + khash_t(s) *h; + int beg, end; + + beg = end = -1; + h = fai->hash; + name_end = l = strlen(str); + s = (char*)malloc(l+1); + // remove space + for (i = k = 0; i < l; ++i) + if (!isspace(str[i])) s[k++] = str[i]; + s[k] = 0; l = k; + // determine the sequence name + for (i = l - 1; i >= 0; --i) if (s[i] == ':') break; // look for colon from the end + if (i >= 0) name_end = i; + if (name_end < l) { // check if this is really the end + int n_hyphen = 0; + for (i = name_end + 1; i < l; ++i) { + if (s[i] == '-') ++n_hyphen; + else if (!isdigit(s[i]) && s[i] != ',') break; + } + if (i < l || n_hyphen > 1) name_end = l; // malformated region string; then take str as the name + s[name_end] = 0; + iter = kh_get(s, h, s); + if (iter == kh_end(h)) { // cannot find the sequence name + iter = kh_get(s, h, str); // try str as the name + if (iter == kh_end(h)) { + *len = 0; + free(s); return 0; + } else s[name_end] = ':', name_end = l; + } + } else iter = kh_get(s, h, str); + if(iter == kh_end(h)) { + fprintf(stderr, "[fai_fetch] Warning - Reference %s not found in FASTA file, returning empty sequence\n", str); + free(s); + *len = -2; + return 0; + }; + val = kh_value(h, iter); + // parse the interval + if (name_end < l) { + for (i = k = name_end + 1; i < l; ++i) + if (s[i] != ',') s[k++] = s[i]; + s[k] = 0; + beg = atoi(s + name_end + 1); + for (i = name_end + 1; i != k; ++i) if (s[i] == '-') break; + end = i < k? atoi(s + i + 1) : val.len; + if (beg > 0) --beg; + } else beg = 0, end = val.len; + if (beg >= val.len) beg = val.len; + if (end >= val.len) end = val.len; + if (beg > end) beg = end; + free(s); + + // now retrieve the sequence + int ret = bgzf_useek(fai->bgzf, val.offset + beg / val.line_blen * val.line_len + beg % val.line_blen, SEEK_SET); + if ( ret<0 ) + { + *len = -1; + fprintf(stderr, "[fai_fetch] Error: fai_fetch failed. (Seeking in a compressed, .gzi unindexed, file?)\n"); + return NULL; + } + l = 0; + s = (char*)malloc(end - beg + 2); + while ( (c=bgzf_getc(fai->bgzf))>=0 && l < end - beg ) + if (isgraph(c)) s[l++] = c; + s[l] = '\0'; + *len = l; + return s; +} + +int faidx_fetch_nseq(const faidx_t *fai) +{ + return fai->n; +} + +int faidx_nseq(const faidx_t *fai) +{ + return fai->n; +} + +const char *faidx_iseq(const faidx_t *fai, int i) +{ + return fai->name[i]; +} + +int faidx_seq_len(const faidx_t *fai, const char *seq) +{ + khint_t k = kh_get(s, fai->hash, seq); + if ( k == kh_end(fai->hash) ) return -1; + return kh_val(fai->hash, k).len; +} + +char *faidx_fetch_seq(const faidx_t *fai, const char *c_name, int p_beg_i, int p_end_i, int *len) +{ + int l, c; + khiter_t iter; + faidx1_t val; + char *seq=NULL; + + // Adjust position + iter = kh_get(s, fai->hash, c_name); + if (iter == kh_end(fai->hash)) + { + *len = -2; + fprintf(stderr, "[fai_fetch_seq] The sequence \"%s\" not found\n", c_name); + return NULL; + } + val = kh_value(fai->hash, iter); + if(p_end_i < p_beg_i) p_beg_i = p_end_i; + if(p_beg_i < 0) p_beg_i = 0; + else if(val.len <= p_beg_i) p_beg_i = val.len - 1; + if(p_end_i < 0) p_end_i = 0; + else if(val.len <= p_end_i) p_end_i = val.len - 1; + + // Now retrieve the sequence + int ret = bgzf_useek(fai->bgzf, val.offset + p_beg_i / val.line_blen * val.line_len + p_beg_i % val.line_blen, SEEK_SET); + if ( ret<0 ) + { + *len = -1; + fprintf(stderr, "[fai_fetch_seq] Error: fai_fetch failed. (Seeking in a compressed, .gzi unindexed, file?)\n"); + return NULL; + } + l = 0; + seq = (char*)malloc(p_end_i - p_beg_i + 2); + while ( (c=bgzf_getc(fai->bgzf))>=0 && l < p_end_i - p_beg_i + 1) + if (isgraph(c)) seq[l++] = c; + seq[l] = '\0'; + *len = l; + return seq; +} + +int faidx_has_seq(const faidx_t *fai, const char *seq) +{ + khiter_t iter = kh_get(s, fai->hash, seq); + if (iter == kh_end(fai->hash)) return 0; + return 1; +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/hfile.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,547 @@ +/* hfile.c -- buffered low-level input/output streams. + + Copyright (C) 2013-2015 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> +#include <stdlib.h> +#include <string.h> +#include <errno.h> + +#include "htslib/hfile.h" +#include "hfile_internal.h" + +/* hFILE fields are used as follows: + + char *buffer; // Pointer to the start of the I/O buffer + char *begin; // First not-yet-read character / unused position + char *end; // First unfilled/unfillable position + char *limit; // Pointer to the first position past the buffer + + const hFILE_backend *backend; // Methods to refill/flush I/O buffer + + off_t offset; // Offset within the stream of buffer position 0 + int at_eof:1; // For reading, whether EOF has been seen + int has_errno; // Error number from the last failure on this stream + +For reading, begin is the first unread character in the buffer and end is the +first unfilled position: + + -----------ABCDEFGHIJKLMNO--------------- + ^buffer ^begin ^end ^limit + +For writing, begin is the first unused position and end is unused so remains +equal to buffer: + + ABCDEFGHIJKLMNOPQRSTUVWXYZ--------------- + ^buffer ^begin ^limit + ^end + +Thus if begin > end then there is a non-empty write buffer, if begin < end +then there is a non-empty read buffer, and if begin == end then both buffers +are empty. In all cases, the stream's file position indicator corresponds +to the position pointed to by begin. */ + +hFILE *hfile_init(size_t struct_size, const char *mode, size_t capacity) +{ + hFILE *fp = (hFILE *) malloc(struct_size); + if (fp == NULL) goto error; + + if (capacity == 0) capacity = 32768; + // FIXME For now, clamp input buffer sizes so mpileup doesn't eat memory + if (strchr(mode, 'r') && capacity > 32768) capacity = 32768; + + fp->buffer = (char *) malloc(capacity); + if (fp->buffer == NULL) goto error; + + fp->begin = fp->end = fp->buffer; + fp->limit = &fp->buffer[capacity]; + + fp->offset = 0; + fp->at_eof = 0; + fp->has_errno = 0; + return fp; + +error: + hfile_destroy(fp); + return NULL; +} + +void hfile_destroy(hFILE *fp) +{ + int save = errno; + if (fp) free(fp->buffer); + free(fp); + errno = save; +} + +static inline int writebuffer_is_nonempty(hFILE *fp) +{ + return fp->begin > fp->end; +} + +/* Refills the read buffer from the backend (once, so may only partially + fill the buffer), returning the number of additional characters read + (which might be 0), or negative when an error occurred. */ +static ssize_t refill_buffer(hFILE *fp) +{ + ssize_t n; + + // Move any unread characters to the start of the buffer + if (fp->begin > fp->buffer) { + fp->offset += fp->begin - fp->buffer; + memmove(fp->buffer, fp->begin, fp->end - fp->begin); + fp->end = &fp->buffer[fp->end - fp->begin]; + fp->begin = fp->buffer; + } + + // Read into the available buffer space at fp->[end,limit) + if (fp->at_eof || fp->end == fp->limit) n = 0; + else { + n = fp->backend->read(fp, fp->end, fp->limit - fp->end); + if (n < 0) { fp->has_errno = errno; return n; } + else if (n == 0) fp->at_eof = 1; + } + + fp->end += n; + return n; +} + +/* Called only from hgetc(), when our buffer is empty. */ +int hgetc2(hFILE *fp) +{ + return (refill_buffer(fp) > 0)? (unsigned char) *(fp->begin++) : EOF; +} + +ssize_t hpeek(hFILE *fp, void *buffer, size_t nbytes) +{ + size_t n = fp->end - fp->begin; + while (n < nbytes) { + ssize_t ret = refill_buffer(fp); + if (ret < 0) return ret; + else if (ret == 0) break; + else n += ret; + } + + if (n > nbytes) n = nbytes; + memcpy(buffer, fp->begin, n); + return n; +} + +/* Called only from hread(); when called, our buffer is empty and nread bytes + have already been placed in the destination buffer. */ +ssize_t hread2(hFILE *fp, void *destv, size_t nbytes, size_t nread) +{ + const size_t capacity = fp->limit - fp->buffer; + char *dest = (char *) destv; + dest += nread, nbytes -= nread; + + // Read large requests directly into the destination buffer + while (nbytes * 2 >= capacity && !fp->at_eof) { + ssize_t n = fp->backend->read(fp, dest, nbytes); + if (n < 0) { fp->has_errno = errno; return n; } + else if (n == 0) fp->at_eof = 1; + fp->offset += n; + dest += n, nbytes -= n; + nread += n; + } + + while (nbytes > 0 && !fp->at_eof) { + size_t n; + ssize_t ret = refill_buffer(fp); + if (ret < 0) return ret; + + n = fp->end - fp->begin; + if (n > nbytes) n = nbytes; + memcpy(dest, fp->begin, n); + fp->begin += n; + dest += n, nbytes -= n; + nread += n; + } + + return nread; +} + +/* Flushes the write buffer, fp->[buffer,begin), out through the backend + returning 0 on success or negative if an error occurred. */ +static ssize_t flush_buffer(hFILE *fp) +{ + const char *buffer = fp->buffer; + while (buffer < fp->begin) { + ssize_t n = fp->backend->write(fp, buffer, fp->begin - buffer); + if (n < 0) { fp->has_errno = errno; return n; } + buffer += n; + fp->offset += n; + } + + fp->begin = fp->buffer; // Leave the buffer empty + return 0; +} + +int hflush(hFILE *fp) +{ + if (flush_buffer(fp) < 0) return EOF; + if (fp->backend->flush(fp) < 0) { fp->has_errno = errno; return EOF; } + return 0; +} + +/* Called only from hputc(), when our buffer is already full. */ +int hputc2(int c, hFILE *fp) +{ + if (flush_buffer(fp) < 0) return EOF; + *(fp->begin++) = c; + return c; +} + +/* Called only from hwrite() and hputs2(); when called, our buffer is full and + ncopied bytes from the source have already been copied to our buffer. */ +ssize_t hwrite2(hFILE *fp, const void *srcv, size_t totalbytes, size_t ncopied) +{ + const char *src = (const char *) srcv; + ssize_t ret; + const size_t capacity = fp->limit - fp->buffer; + size_t remaining = totalbytes - ncopied; + src += ncopied; + + ret = flush_buffer(fp); + if (ret < 0) return ret; + + // Write large blocks out directly from the source buffer + while (remaining * 2 >= capacity) { + ssize_t n = fp->backend->write(fp, src, remaining); + if (n < 0) { fp->has_errno = errno; return n; } + fp->offset += n; + src += n, remaining -= n; + } + + // Just buffer any remaining characters + memcpy(fp->begin, src, remaining); + fp->begin += remaining; + + return totalbytes; +} + +/* Called only from hputs(), when our buffer is already full. */ +int hputs2(const char *text, size_t totalbytes, size_t ncopied, hFILE *fp) +{ + return (hwrite2(fp, text, totalbytes, ncopied) >= 0)? 0 : EOF; +} + +off_t hseek(hFILE *fp, off_t offset, int whence) +{ + off_t pos; + + if (writebuffer_is_nonempty(fp)) { + int ret = flush_buffer(fp); + if (ret < 0) return ret; + } + else { + // Convert relative offsets from being relative to the hFILE's stream + // position (at begin) to being relative to the backend's physical + // stream position (at end, due to the buffering read-ahead). + if (whence == SEEK_CUR) offset -= fp->end - fp->begin; + } + + pos = fp->backend->seek(fp, offset, whence); + if (pos < 0) { fp->has_errno = errno; return pos; } + + // Seeking succeeded, so discard any non-empty read buffer + fp->begin = fp->end = fp->buffer; + fp->at_eof = 0; + + fp->offset = pos; + return pos; +} + +int hclose(hFILE *fp) +{ + int err = fp->has_errno; + + if (writebuffer_is_nonempty(fp) && hflush(fp) < 0) err = fp->has_errno; + if (fp->backend->close(fp) < 0) err = errno; + hfile_destroy(fp); + + if (err) { + errno = err; + return EOF; + } + else return 0; +} + +void hclose_abruptly(hFILE *fp) +{ + int save = errno; + if (fp->backend->close(fp) < 0) { /* Ignore subsequent errors */ } + hfile_destroy(fp); + errno = save; +} + + +/*************************** + * File descriptor backend * + ***************************/ + +#include <sys/socket.h> +#include <sys/stat.h> +#include <fcntl.h> +#include <unistd.h> + +#ifdef _WIN32 +#define HAVE_CLOSESOCKET +#endif + +/* For Unix, it doesn't matter whether a file descriptor is a socket. + However Windows insists on send()/recv() and its own closesocket() + being used when fd happens to be a socket. */ + +typedef struct { + hFILE base; + int fd; + int is_socket:1; +} hFILE_fd; + +static ssize_t fd_read(hFILE *fpv, void *buffer, size_t nbytes) +{ + hFILE_fd *fp = (hFILE_fd *) fpv; + ssize_t n; + do { + n = fp->is_socket? recv(fp->fd, buffer, nbytes, 0) + : read(fp->fd, buffer, nbytes); + } while (n < 0 && errno == EINTR); + return n; +} + +static ssize_t fd_write(hFILE *fpv, const void *buffer, size_t nbytes) +{ + hFILE_fd *fp = (hFILE_fd *) fpv; + ssize_t n; + do { + n = fp->is_socket? send(fp->fd, buffer, nbytes, 0) + : write(fp->fd, buffer, nbytes); + } while (n < 0 && errno == EINTR); + return n; +} + +static off_t fd_seek(hFILE *fpv, off_t offset, int whence) +{ + hFILE_fd *fp = (hFILE_fd *) fpv; + return lseek(fp->fd, offset, whence); +} + +static int fd_flush(hFILE *fpv) +{ + hFILE_fd *fp = (hFILE_fd *) fpv; + int ret; + do { +#ifdef HAVE_FDATASYNC + ret = fdatasync(fp->fd); +#else + ret = fsync(fp->fd); +#endif + // Ignore invalid-for-fsync(2) errors due to being, e.g., a pipe, + // and operation-not-supported errors (Mac OS X) + if (ret < 0 && (errno == EINVAL || errno == ENOTSUP)) ret = 0; + } while (ret < 0 && errno == EINTR); + return ret; +} + +static int fd_close(hFILE *fpv) +{ + hFILE_fd *fp = (hFILE_fd *) fpv; + int ret; + do { +#ifdef HAVE_CLOSESOCKET + ret = fp->is_socket? closesocket(fp->fd) : close(fp->fd); +#else + ret = close(fp->fd); +#endif + } while (ret < 0 && errno == EINTR); + return ret; +} + +static const struct hFILE_backend fd_backend = +{ + fd_read, fd_write, fd_seek, fd_flush, fd_close +}; + +static size_t blksize(int fd) +{ + struct stat sbuf; + if (fstat(fd, &sbuf) != 0) return 0; + return sbuf.st_blksize; +} + +static hFILE *hopen_fd(const char *filename, const char *mode) +{ + hFILE_fd *fp = NULL; + int fd = open(filename, hfile_oflags(mode), 0666); + if (fd < 0) goto error; + + fp = (hFILE_fd *) hfile_init(sizeof (hFILE_fd), mode, blksize(fd)); + if (fp == NULL) goto error; + + fp->fd = fd; + fp->is_socket = 0; + fp->base.backend = &fd_backend; + return &fp->base; + +error: + if (fd >= 0) { int save = errno; (void) close(fd); errno = save; } + hfile_destroy((hFILE *) fp); + return NULL; +} + +hFILE *hdopen(int fd, const char *mode) +{ + hFILE_fd *fp = (hFILE_fd*) hfile_init(sizeof (hFILE_fd), mode, blksize(fd)); + if (fp == NULL) return NULL; + + fp->fd = fd; + fp->is_socket = (strchr(mode, 's') != NULL); + fp->base.backend = &fd_backend; + return &fp->base; +} + +static hFILE *hopen_fd_stdinout(const char *mode) +{ + int fd = (strchr(mode, 'r') != NULL)? STDIN_FILENO : STDOUT_FILENO; + // TODO Set binary mode (for Windows) + return hdopen(fd, mode); +} + +int hfile_oflags(const char *mode) +{ + int rdwr = 0, flags = 0; + const char *s; + for (s = mode; *s; s++) + switch (*s) { + case 'r': rdwr = O_RDONLY; break; + case 'w': rdwr = O_WRONLY; flags |= O_CREAT | O_TRUNC; break; + case 'a': rdwr = O_WRONLY; flags |= O_CREAT | O_APPEND; break; + case '+': rdwr = O_RDWR; break; + default: break; + } + +#ifdef O_BINARY + flags |= O_BINARY; +#endif + + return rdwr | flags; +} + + +/********************* + * In-memory backend * + *********************/ + +typedef struct { + hFILE base; + const char *buffer; + size_t length, pos; +} hFILE_mem; + +static ssize_t mem_read(hFILE *fpv, void *buffer, size_t nbytes) +{ + hFILE_mem *fp = (hFILE_mem *) fpv; + size_t avail = fp->length - fp->pos; + if (nbytes > avail) nbytes = avail; + memcpy(buffer, fp->buffer + fp->pos, nbytes); + fp->pos += nbytes; + return nbytes; +} + +static off_t mem_seek(hFILE *fpv, off_t offset, int whence) +{ + hFILE_mem *fp = (hFILE_mem *) fpv; + size_t absoffset = (offset >= 0)? offset : -offset; + size_t origin; + + switch (whence) { + case SEEK_SET: origin = 0; break; + case SEEK_CUR: origin = fp->pos; break; + case SEEK_END: origin = fp->length; break; + default: errno = EINVAL; return -1; + } + + if ((offset < 0 && absoffset > origin) || + (offset >= 0 && absoffset > fp->length - origin)) { + errno = EINVAL; + return -1; + } + + fp->pos = origin + offset; + return fp->pos; +} + +static int mem_close(hFILE *fpv) +{ + return 0; +} + +static const struct hFILE_backend mem_backend = +{ + mem_read, NULL, mem_seek, NULL, mem_close +}; + +static hFILE *hopen_mem(const char *data, const char *mode) +{ + // TODO Implement write modes, which will require memory allocation + if (strchr(mode, 'r') == NULL) { errno = EINVAL; return NULL; } + + hFILE_mem *fp = (hFILE_mem *) hfile_init(sizeof (hFILE_mem), mode, 0); + if (fp == NULL) return NULL; + + fp->buffer = data; + fp->length = strlen(data); + fp->pos = 0; + fp->base.backend = &mem_backend; + return &fp->base; +} + + +/****************************** + * hopen() backend dispatcher * + ******************************/ + +hFILE *hopen(const char *fname, const char *mode) +{ + if (strncmp(fname, "http://", 7) == 0 || + strncmp(fname, "ftp://", 6) == 0) return hopen_net(fname, mode); +#ifdef HAVE_IRODS + else if (strncmp(fname, "irods:", 6) == 0) return hopen_irods(fname, mode); +#endif + else if (strncmp(fname, "data:", 5) == 0) return hopen_mem(fname + 5, mode); + else if (strcmp(fname, "-") == 0) return hopen_fd_stdinout(mode); + else return hopen_fd(fname, mode); +} + +int hisremote(const char *fname) +{ + // FIXME Make a new backend entry to return this + if (strncmp(fname, "http://", 7) == 0 || + strncmp(fname, "https://", 8) == 0 || + strncmp(fname, "ftp://", 6) == 0) return 1; +#ifdef HAVE_IRODS + else if (strncmp(fname, "irods:", 6) == 0) return 1; +#endif + else return 0; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/hfile_internal.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,76 @@ +/* hfile_internal.h -- internal parts of low-level input/output streams. + + Copyright (C) 2013-2015 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HFILE_INTERNAL_H +#define HFILE_INTERNAL_H + +#include "htslib/hfile.h" + +struct hFILE_backend { + /* As per read(2), returning the number of bytes read (possibly 0) or + negative (and setting errno) on errors. Front-end code will call this + repeatedly if necessary to attempt to get the desired byte count. */ + ssize_t (*read)(hFILE *fp, void *buffer, size_t nbytes) HTS_RESULT_USED; + + /* As per write(2), returning the number of bytes written or negative (and + setting errno) on errors. Front-end code will call this repeatedly if + necessary until the desired block is written or an error occurs. */ + ssize_t (*write)(hFILE *fp, const void *buffer, size_t nbytes) + HTS_RESULT_USED; + + /* As per lseek(2), returning the resulting offset within the stream or + negative (and setting errno) on errors. */ + off_t (*seek)(hFILE *fp, off_t offset, int whence) HTS_RESULT_USED; + + /* Performs low-level flushing, if any, e.g., fsync(2); for writing streams + only. Returns 0 for success or negative (and sets errno) on errors. */ + int (*flush)(hFILE *fp) HTS_RESULT_USED; + + /* Closes the underlying stream (for output streams, the buffer will + already have been flushed), returning 0 for success or negative (and + setting errno) on errors, as per close(2). */ + int (*close)(hFILE *fp) HTS_RESULT_USED; +}; + +/* These are called from the hopen() dispatcher, and should call hfile_init() + to malloc a struct "derived" from hFILE and initialise it appropriately, + including setting base.backend to their own backend vector. */ +hFILE *hopen_irods(const char *filename, const char *mode); +hFILE *hopen_net(const char *filename, const char *mode); + +/* May be called by hopen_*() functions to decode a fopen()-style mode into + open(2)-style flags. */ +int hfile_oflags(const char *mode); + +/* Must be called by hopen_*() functions to allocate the hFILE struct and set + up its base. Capacity is a suggested buffer size (e.g., via fstat(2)) + or 0 for a default-sized buffer. */ +hFILE *hfile_init(size_t struct_size, const char *mode, size_t capacity); + +/* May be called by hopen_*() functions to undo the effects of hfile_init() + in the event opening the stream subsequently fails. (This is safe to use + even if fp is NULL. This takes care to preserve errno.) */ +void hfile_destroy(hFILE *fp); + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/hfile_irods.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,243 @@ +/* hfile_irods.c -- iRODS backend for low-level file streams. + + Copyright (C) 2013, 2015 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdlib.h> +#include <string.h> +#include <errno.h> + +#include "hfile_internal.h" + +#include <rcConnect.h> +#include <dataObjOpen.h> +#include <dataObjRead.h> +#include <dataObjWrite.h> +#include <dataObjFsync.h> +#include <dataObjLseek.h> +#include <dataObjClose.h> + +typedef struct { + hFILE base; + int descriptor; +} hFILE_irods; + +static int status_errno(int status) +{ + switch (status) { + case SYS_NO_API_PRIV: return EACCES; + case SYS_MALLOC_ERR: return ENOMEM; + case SYS_OUT_OF_FILE_DESC: return ENFILE; + case SYS_BAD_FILE_DESCRIPTOR: return EBADF; + case CAT_NO_ROWS_FOUND: return ENOENT; + case CATALOG_ALREADY_HAS_ITEM_BY_THAT_NAME: return EEXIST; + default: return EIO; + } +} + +static void set_errno(int status) +{ + int err = abs(status) % 1000; + errno = err? err : status_errno(status); +} + +static struct { + rcComm_t *conn; + rodsEnv env; +} irods = { NULL }; + +static void irods_exit() +{ + (void) rcDisconnect(irods.conn); + irods.conn = NULL; +} + +static int irods_init() +{ + rErrMsg_t err; + int ret; + + ret = getRodsEnv(&irods.env); + if (ret < 0) goto error; + + irods.conn = rcConnect(irods.env.rodsHost, irods.env.rodsPort, + irods.env.rodsUserName, irods.env.rodsZone, + NO_RECONN, &err); + if (irods.conn == NULL) { ret = err.status; goto error; } + + if (strcmp(irods.env.rodsUserName, PUBLIC_USER_NAME) != 0) { + ret = clientLogin(irods.conn); + if (ret != 0) goto error; + } + + // In the unlikely event atexit() fails, it's better to succeed here and + // carry on and do the I/O; then eventually when the program exits, we'll + // merely disconnect from the server uncleanly, as if we had aborted. + (void) atexit(irods_exit); + + return 0; + +error: + if (irods.conn) { (void) rcDisconnect(irods.conn); } + irods.conn = NULL; + set_errno(ret); + return -1; +} + +static ssize_t irods_read(hFILE *fpv, void *buffer, size_t nbytes) +{ + hFILE_irods *fp = (hFILE_irods *) fpv; + openedDataObjInp_t args; + bytesBuf_t buf; + int ret; + + memset(&args, 0, sizeof args); + args.l1descInx = fp->descriptor; + args.len = nbytes; + + buf.buf = buffer; + buf.len = nbytes; + + ret = rcDataObjRead(irods.conn, &args, &buf); + if (ret < 0) set_errno(ret); + return ret; +} + +static ssize_t irods_write(hFILE *fpv, const void *buffer, size_t nbytes) +{ + hFILE_irods *fp = (hFILE_irods *) fpv; + openedDataObjInp_t args; + bytesBuf_t buf; + int ret; + + memset(&args, 0, sizeof args); + args.l1descInx = fp->descriptor; + args.len = nbytes; + + buf.buf = (void *) buffer; // ...the iRODS API is not const-correct here + buf.len = nbytes; + + ret = rcDataObjWrite(irods.conn, &args, &buf); + if (ret < 0) set_errno(ret); + return ret; +} + +static off_t irods_seek(hFILE *fpv, off_t offset, int whence) +{ + hFILE_irods *fp = (hFILE_irods *) fpv; + openedDataObjInp_t args; + fileLseekOut_t *out = NULL; + int ret; + + memset(&args, 0, sizeof args); + args.l1descInx = fp->descriptor; + args.offset = offset; + args.whence = whence; + + ret = rcDataObjLseek(irods.conn, &args, &out); + + if (out) { offset = out->offset; free(out); } + else offset = -1; + if (ret < 0) { set_errno(ret); return -1; } + return offset; +} + +static int irods_flush(hFILE *fpv) +{ +// FIXME rcDataObjFsync() doesn't seem to function as expected. +// For now, flush is a no-op: see https://github.com/samtools/htslib/issues/168 +#if 0 + hFILE_irods *fp = (hFILE_irods *) fpv; + openedDataObjInp_t args; + int ret; + + memset(&args, 0, sizeof args); + args.l1descInx = fp->descriptor; + + ret = rcDataObjFsync(irods.conn, &args); + if (ret < 0) set_errno(ret); + return ret; +#endif + return 0; +} + +static int irods_close(hFILE *fpv) +{ + hFILE_irods *fp = (hFILE_irods *) fpv; + openedDataObjInp_t args; + int ret; + + memset(&args, 0, sizeof args); + args.l1descInx = fp->descriptor; + + ret = rcDataObjClose(irods.conn, &args); + if (ret < 0) set_errno(ret); + return ret; +} + +static const struct hFILE_backend irods_backend = +{ + irods_read, irods_write, irods_seek, irods_flush, irods_close +}; + +hFILE *hopen_irods(const char *filename, const char *mode) +{ + hFILE_irods *fp; + rodsPath_t path; + dataObjInp_t args; + int ret; + + // Initialise the iRODS connection if this is the first use. + if (irods.conn == NULL) { if (irods_init() < 0) return NULL; } + + if (strncmp(filename, "irods:", 6) == 0) filename += 6; + else { errno = EINVAL; return NULL; } + + fp = (hFILE_irods *) hfile_init(sizeof (hFILE_irods), mode, 0); + if (fp == NULL) return NULL; + + strncpy(path.inPath, filename, MAX_NAME_LEN-1); + path.inPath[MAX_NAME_LEN-1] = '\0'; + + ret = parseRodsPath(&path, &irods.env); + if (ret < 0) goto error; + + memset(&args, 0, sizeof args); + strcpy(args.objPath, path.outPath); + args.openFlags = hfile_oflags(mode); + if (args.openFlags & O_CREAT) { + args.createMode = 0666; + addKeyVal(&args.condInput, DEST_RESC_NAME_KW,irods.env.rodsDefResource); + } + + ret = rcDataObjOpen(irods.conn, &args); + if (ret < 0) goto error; + fp->descriptor = ret; + + fp->base.backend = &irods_backend; + return &fp->base; + +error: + hfile_destroy((hFILE *) fp); + set_errno(ret); + return NULL; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/hfile_net.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,99 @@ +/* hfile_net.c -- network backend for low-level input/output streams. + + Copyright (C) 2013-2014 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdlib.h> +#include <errno.h> + +#include "hfile_internal.h" + +#include "htslib/knetfile.h" + +typedef struct { + hFILE base; + knetFile *netfp; +} hFILE_net; + +static int net_inited = 0; + +#ifdef _WIN32 +static void net_exit(void) +{ + knet_win32_destroy(); +} +#endif + +static int net_init(void) +{ +#ifdef _WIN32 + if (knet_win32_init() != 0) return -1; + + // In the unlikely event atexit() fails, it's better to succeed here and + // carry on and do the I/O; then eventually when the program exits, we'll + // merely have failed to clean up properly, as if we had aborted. + (void) atexit(net_exit); +#endif + + net_inited = 1; + return 0; +} + +static ssize_t net_read(hFILE *fpv, void *buffer, size_t nbytes) +{ + hFILE_net *fp = (hFILE_net *) fpv; + return knet_read(fp->netfp, buffer, nbytes); +} + +static off_t net_seek(hFILE *fpv, off_t offset, int whence) +{ + hFILE_net *fp = (hFILE_net *) fpv; + return knet_seek(fp->netfp, offset, whence); +} + +static int net_close(hFILE *fpv) +{ + hFILE_net *fp = (hFILE_net *) fpv; + return knet_close(fp->netfp); +} + +static const struct hFILE_backend net_backend = +{ + net_read, NULL, net_seek, NULL, net_close +}; + +hFILE *hopen_net(const char *filename, const char *mode) +{ + hFILE_net *fp; + + // Do any networking initialisation if this is the first use. + if (! net_inited) { if (net_init() < 0) return NULL; } + + fp = (hFILE_net *) hfile_init(sizeof (hFILE_net), mode, 0); + if (fp == NULL) return NULL; + + fp->netfp = knet_open(filename, mode); + if (fp->netfp == NULL) { hfile_destroy((hFILE *) fp); return NULL; } + + fp->base.backend = &net_backend; + return &fp->base; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/hts.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1665 @@ +/* hts.c -- format-neutral I/O, indexing, and iterator API functions. + + Copyright (C) 2008, 2009, 2012-2015 Genome Research Ltd. + Copyright (C) 2012, 2013 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <zlib.h> +#include <ctype.h> +#include <stdio.h> +#include <string.h> +#include <stdlib.h> +#include <limits.h> +#include <fcntl.h> +#include <errno.h> +#include <sys/stat.h> +#include "htslib/bgzf.h" +#include "htslib/hts.h" +#include "cram/cram.h" +#include "htslib/hfile.h" +#include "version.h" + +#include "htslib/kseq.h" +#define KS_BGZF 1 +#if KS_BGZF + // bgzf now supports gzip-compressed files, the gzFile branch can be removed + KSTREAM_INIT2(, BGZF*, bgzf_read, 65536) +#else + KSTREAM_INIT2(, gzFile, gzread, 16384) +#endif + +#include "htslib/khash.h" +KHASH_INIT2(s2i,, kh_cstr_t, int64_t, 1, kh_str_hash_func, kh_str_hash_equal) + +int hts_verbose = 3; + +const char *hts_version() +{ + return HTS_VERSION; +} + +const unsigned char seq_nt16_table[256] = { + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 1, 2, 4, 8, 15,15,15,15, 15,15,15,15, 15, 0 /*=*/,15,15, + 15, 1,14, 2, 13,15,15, 4, 11,15,15,12, 15, 3,15,15, + 15,15, 5, 6, 8,15, 7, 9, 15,10,15,15, 15,15,15,15, + 15, 1,14, 2, 13,15,15, 4, 11,15,15,12, 15, 3,15,15, + 15,15, 5, 6, 8,15, 7, 9, 15,10,15,15, 15,15,15,15, + + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15, + 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15 +}; + +const char seq_nt16_str[] = "=ACMGRSVTWYHKDBN"; + +const int seq_nt16_int[] = { 4, 0, 1, 4, 2, 4, 4, 4, 3, 4, 4, 4, 4, 4, 4, 4 }; + +/********************** + *** Basic file I/O *** + **********************/ + +static enum htsFormatCategory format_category(enum htsExactFormat fmt) +{ + switch (fmt) { + case bam: + case sam: + case cram: + return sequence_data; + + case vcf: + case bcf: + return variant_data; + + case bai: + case crai: + case csi: + case gzi: + case tbi: + return index_file; + + case bed: + return region_list; + + case unknown_format: + case binary_format: + case text_format: + case format_maximum: + break; + } + + return unknown_category; +} + +// Decompress up to ten or so bytes by peeking at the file, which must be +// positioned at the start of a GZIP block. +static size_t decompress_peek(hFILE *fp, unsigned char *dest, size_t destsize) +{ + // Typically at most a couple of hundred bytes of input are required + // to get a few bytes of output from inflate(), so hopefully this buffer + // size suffices in general. + unsigned char buffer[512]; + z_stream zs; + ssize_t npeek = hpeek(fp, buffer, sizeof buffer); + + if (npeek < 0) return 0; + + zs.zalloc = NULL; + zs.zfree = NULL; + zs.next_in = buffer; + zs.avail_in = npeek; + zs.next_out = dest; + zs.avail_out = destsize; + if (inflateInit2(&zs, 31) != Z_OK) return 0; + + while (zs.total_out < destsize) + if (inflate(&zs, Z_SYNC_FLUSH) != Z_OK) break; + + destsize = zs.total_out; + inflateEnd(&zs); + + return destsize; +} + +// Parse "x.y" text, taking care because the string is not NUL-terminated +// and filling in major/minor only when the digits are followed by a delimiter, +// so we don't misread "1.10" as "1.1" due to reaching the end of the buffer. +static void +parse_version(htsFormat *fmt, const unsigned char *u, const unsigned char *ulim) +{ + const char *str = (const char *) u; + const char *slim = (const char *) ulim; + const char *s; + + fmt->version.major = fmt->version.minor = -1; + + for (s = str; s < slim; s++) if (!isdigit(*s)) break; + if (s < slim) { + fmt->version.major = atoi(str); + if (*s == '.') { + str = &s[1]; + for (s = str; s < slim; s++) if (!isdigit(*s)) break; + if (s < slim) + fmt->version.minor = atoi(str); + } + else + fmt->version.minor = 0; + } +} + +int hts_detect_format(hFILE *hfile, htsFormat *fmt) +{ + unsigned char s[21]; + ssize_t len = hpeek(hfile, s, 18); + if (len < 0) return -1; + + if (len >= 2 && s[0] == 0x1f && s[1] == 0x8b) { + // The stream is either gzip-compressed or BGZF-compressed. + // Determine which, and decompress the first few bytes. + fmt->compression = (len >= 18 && (s[3] & 4) && + memcmp(&s[12], "BC\2\0", 4) == 0)? bgzf : gzip; + len = decompress_peek(hfile, s, sizeof s); + } + else { + fmt->compression = no_compression; + len = hpeek(hfile, s, sizeof s); + } + if (len < 0) return -1; + + fmt->compression_level = -1; + fmt->specific = NULL; + + if (len >= 6 && memcmp(s,"CRAM",4) == 0 && s[4]>=1 && s[4]<=3 && s[5]<=1) { + fmt->category = sequence_data; + fmt->format = cram; + fmt->version.major = s[4], fmt->version.minor = s[5]; + fmt->compression = custom; + return 0; + } + else if (len >= 4 && s[3] <= '\4') { + if (memcmp(s, "BAM\1", 4) == 0) { + fmt->category = sequence_data; + fmt->format = bam; + // TODO Decompress enough to pick version from @HD-VN header + fmt->version.major = 1, fmt->version.minor = -1; + return 0; + } + else if (memcmp(s, "BAI\1", 4) == 0) { + fmt->category = index_file; + fmt->format = bai; + fmt->version.major = -1, fmt->version.minor = -1; + return 0; + } + else if (memcmp(s, "BCF\4", 4) == 0) { + fmt->category = variant_data; + fmt->format = bcf; + fmt->version.major = 1, fmt->version.minor = -1; + return 0; + } + else if (memcmp(s, "BCF\2", 4) == 0) { + fmt->category = variant_data; + fmt->format = bcf; + fmt->version.major = s[3]; + fmt->version.minor = (len >= 5 && s[4] <= 2)? s[4] : 0; + return 0; + } + else if (memcmp(s, "CSI\1", 4) == 0) { + fmt->category = index_file; + fmt->format = csi; + fmt->version.major = 1, fmt->version.minor = -1; + return 0; + } + else if (memcmp(s, "TBI\1", 4) == 0) { + fmt->category = index_file; + fmt->format = tbi; + fmt->version.major = -1, fmt->version.minor = -1; + return 0; + } + } + else if (len >= 16 && memcmp(s, "##fileformat=VCF", 16) == 0) { + fmt->category = variant_data; + fmt->format = vcf; + if (len >= 21 && s[16] == 'v') + parse_version(fmt, &s[17], &s[len]); + else + fmt->version.major = fmt->version.minor = -1; + return 0; + } + else if (len >= 4 && s[0] == '@' && + (memcmp(s, "@HD\t", 4) == 0 || memcmp(s, "@SQ\t", 4) == 0 || + memcmp(s, "@RG\t", 4) == 0 || memcmp(s, "@PG\t", 4) == 0)) { + fmt->category = sequence_data; + fmt->format = sam; + // @HD-VN is not guaranteed to be the first tag, but then @HD is + // not guaranteed to be present at all... + if (len >= 9 && memcmp(s, "@HD\tVN:", 7) == 0) + parse_version(fmt, &s[7], &s[len]); + else + fmt->version.major = 1, fmt->version.minor = -1; + return 0; + } + else { + // Various possibilities for tab-delimited text: + // .crai (gzipped tab-delimited six columns: seqid 5*number) + // .bed ([3..12] tab-delimited columns) + // .bedpe (>= 10 tab-delimited columns) + // .sam (tab-delimited >= 11 columns: seqid number seqid...) + // FIXME For now, assume it's SAM + fmt->category = sequence_data; + fmt->format = sam; + fmt->version.major = 1, fmt->version.minor = -1; + return 0; + } + + fmt->category = unknown_category; + fmt->format = unknown_format; + fmt->version.major = fmt->version.minor = -1; + fmt->compression = no_compression; + return 0; +} + +char *hts_format_description(const htsFormat *format) +{ + kstring_t str = { 0, 0, NULL }; + + switch (format->format) { + case sam: kputs("SAM", &str); break; + case bam: kputs("BAM", &str); break; + case cram: kputs("CRAM", &str); break; + case vcf: kputs("VCF", &str); break; + case bcf: + if (format->version.major == 1) kputs("Legacy BCF", &str); + else kputs("BCF", &str); + break; + case bai: kputs("BAI", &str); break; + case crai: kputs("CRAI", &str); break; + case csi: kputs("CSI", &str); break; + case tbi: kputs("Tabix", &str); break; + default: kputs("unknown", &str); break; + } + + if (format->version.major >= 0) { + kputs(" version ", &str); + kputw(format->version.major, &str); + if (format->version.minor >= 0) { + kputc('.', &str); + kputw(format->version.minor, &str); + } + } + + switch (format->compression) { + case custom: kputs(" compressed", &str); break; + case gzip: kputs(" gzip-compressed", &str); break; + case bgzf: + switch (format->format) { + case bam: + case bcf: + case csi: + case tbi: + // These are by definition BGZF, so just use the generic term + kputs(" compressed", &str); + break; + default: + kputs(" BGZF-compressed", &str); + break; + } + break; + default: break; + } + + switch (format->category) { + case sequence_data: kputs(" sequence", &str); break; + case variant_data: kputs(" variant calling", &str); break; + case index_file: kputs(" index", &str); break; + case region_list: kputs(" genomic region", &str); break; + default: break; + } + + if (format->compression == no_compression) + switch (format->format) { + case sam: + case crai: + case vcf: + case bed: + kputs(" text", &str); + break; + + default: + kputs(" data", &str); + break; + } + else + kputs(" data", &str); + + return ks_release(&str); +} + +htsFile *hts_open(const char *fn, const char *mode) +{ + htsFile *fp = NULL; + hFILE *hfile = hopen(fn, mode); + if (hfile == NULL) goto error; + + fp = hts_hopen(hfile, fn, mode); + if (fp == NULL) goto error; + + return fp; + +error: + if (hts_verbose >= 2) + fprintf(stderr, "[E::%s] fail to open file '%s'\n", __func__, fn); + + if (hfile) + hclose_abruptly(hfile); + + return NULL; +} + +htsFile *hts_hopen(struct hFILE *hfile, const char *fn, const char *mode) +{ + htsFile *fp = (htsFile*)calloc(1, sizeof(htsFile)); + if (fp == NULL) goto error; + + fp->fn = strdup(fn); + fp->is_be = ed_is_big(); + + if (strchr(mode, 'r')) { + if (hts_detect_format(hfile, &fp->format) < 0) goto error; + } + else if (strchr(mode, 'w') || strchr(mode, 'a')) { + htsFormat *fmt = &fp->format; + fp->is_write = 1; + + if (strchr(mode, 'b')) fmt->format = binary_format; + else if (strchr(mode, 'c')) fmt->format = cram; + else fmt->format = text_format; + + if (strchr(mode, 'z')) fmt->compression = bgzf; + else if (strchr(mode, 'g')) fmt->compression = gzip; + else if (strchr(mode, 'u')) fmt->compression = no_compression; + else { + // No compression mode specified, set to the default for the format + switch (fmt->format) { + case binary_format: fmt->compression = bgzf; break; + case cram: fmt->compression = custom; break; + case text_format: fmt->compression = no_compression; break; + default: abort(); + } + } + + // Fill in category (if determinable; e.g. 'b' could be BAM or BCF) + fmt->category = format_category(fmt->format); + + fmt->version.major = fmt->version.minor = -1; + fmt->compression_level = -1; + fmt->specific = NULL; + } + else goto error; + + switch (fp->format.format) { + case binary_format: + case bam: + case bcf: + fp->fp.bgzf = bgzf_hopen(hfile, mode); + if (fp->fp.bgzf == NULL) goto error; + fp->is_bin = 1; + break; + + case cram: + fp->fp.cram = cram_dopen(hfile, fn, mode); + if (fp->fp.cram == NULL) goto error; + if (!fp->is_write) + cram_set_option(fp->fp.cram, CRAM_OPT_DECODE_MD, 1); + fp->is_cram = 1; + break; + + case text_format: + case sam: + case vcf: + if (!fp->is_write) { + #if KS_BGZF + BGZF *gzfp = bgzf_hopen(hfile, mode); + #else + // TODO Implement gzip hFILE adaptor + hclose(hfile); // This won't work, especially for stdin + gzFile gzfp = strcmp(fn, "-")? gzopen(fn, "rb") : gzdopen(fileno(stdin), "rb"); + #endif + if (gzfp) fp->fp.voidp = ks_init(gzfp); + else goto error; + } + else if (fp->format.compression != no_compression) { + fp->fp.bgzf = bgzf_hopen(hfile, mode); + if (fp->fp.bgzf == NULL) goto error; + } + else + fp->fp.hfile = hfile; + break; + + default: + goto error; + } + + return fp; + +error: + if (hts_verbose >= 2) + fprintf(stderr, "[E::%s] fail to open file '%s'\n", __func__, fn); + + if (fp) { + free(fp->fn); + free(fp->fn_aux); + free(fp); + } + return NULL; +} + +int hts_close(htsFile *fp) +{ + int ret, save; + + switch (fp->format.format) { + case binary_format: + case bam: + case bcf: + ret = bgzf_close(fp->fp.bgzf); + break; + + case cram: + if (!fp->is_write) { + switch (cram_eof(fp->fp.cram)) { + case 0: + fprintf(stderr, "[E::%s] Failed to decode sequence.\n", __func__); + return -1; + case 2: + fprintf(stderr, "[W::%s] EOF marker is absent. The input is probably truncated.\n", __func__); + break; + default: /* case 1, expected EOF */ + break; + } + } + ret = cram_close(fp->fp.cram); + break; + + case text_format: + case sam: + case vcf: + if (!fp->is_write) { + #if KS_BGZF + BGZF *gzfp = ((kstream_t*)fp->fp.voidp)->f; + ret = bgzf_close(gzfp); + #else + gzFile gzfp = ((kstream_t*)fp->fp.voidp)->f; + ret = gzclose(gzfp); + #endif + ks_destroy((kstream_t*)fp->fp.voidp); + } + else if (fp->format.compression != no_compression) + ret = bgzf_close(fp->fp.bgzf); + else + ret = hclose(fp->fp.hfile); + break; + + default: + ret = -1; + break; + } + + save = errno; + free(fp->fn); + free(fp->fn_aux); + free(fp->line.s); + free(fp); + errno = save; + return ret; +} + +const htsFormat *hts_get_format(htsFile *fp) +{ + return fp? &fp->format : NULL; +} + +int hts_set_opt(htsFile *fp, enum cram_option opt, ...) { + int r; + va_list args; + + if (fp->format.format != cram) + return 0; + + va_start(args, opt); + r = cram_set_voption(fp->fp.cram, opt, args); + va_end(args); + + return r; +} + +int hts_set_threads(htsFile *fp, int n) +{ + if (fp->format.compression == bgzf) { + return bgzf_mt(fp->fp.bgzf, n, 256); + } else if (fp->format.format == cram) { + return hts_set_opt(fp, CRAM_OPT_NTHREADS, n); + } + else return 0; +} + +int hts_set_fai_filename(htsFile *fp, const char *fn_aux) +{ + free(fp->fn_aux); + if (fn_aux) { + fp->fn_aux = strdup(fn_aux); + if (fp->fn_aux == NULL) return -1; + } + else fp->fn_aux = NULL; + + if (fp->format.format == cram) + cram_set_option(fp->fp.cram, CRAM_OPT_REFERENCE, fp->fn_aux); + + return 0; +} + +// For VCF/BCF backward sweeper. Not exposing these functions because their +// future is uncertain. Things will probably have to change with hFILE... +BGZF *hts_get_bgzfp(htsFile *fp) +{ + if ( fp->is_bin ) + return fp->fp.bgzf; + else + return ((kstream_t*)fp->fp.voidp)->f; +} +int hts_useek(htsFile *fp, long uoffset, int where) +{ + if ( fp->is_bin ) + return bgzf_useek(fp->fp.bgzf, uoffset, where); + else + { + ks_rewind((kstream_t*)fp->fp.voidp); + ((kstream_t*)fp->fp.voidp)->seek_pos = uoffset; + return bgzf_useek(((kstream_t*)fp->fp.voidp)->f, uoffset, where); + } +} +long hts_utell(htsFile *fp) +{ + if ( fp->is_bin ) + return bgzf_utell(fp->fp.bgzf); + else + return ((kstream_t*)fp->fp.voidp)->seek_pos; +} + +int hts_getline(htsFile *fp, int delimiter, kstring_t *str) +{ + int ret, dret; + ret = ks_getuntil((kstream_t*)fp->fp.voidp, delimiter, str, &dret); + ++fp->lineno; + return ret; +} + +char **hts_readlist(const char *string, int is_file, int *_n) +{ + int m = 0, n = 0, dret; + char **s = 0; + if ( is_file ) + { +#if KS_BGZF + BGZF *fp = bgzf_open(string, "r"); +#else + gzFile fp = gzopen(string, "r"); +#endif + if ( !fp ) return NULL; + + kstream_t *ks; + kstring_t str; + str.s = 0; str.l = str.m = 0; + ks = ks_init(fp); + while (ks_getuntil(ks, KS_SEP_LINE, &str, &dret) >= 0) + { + if (str.l == 0) continue; + n++; + hts_expand(char*,n,m,s); + s[n-1] = strdup(str.s); + } + ks_destroy(ks); +#if KS_BGZF + bgzf_close(fp); +#else + gzclose(fp); +#endif + free(str.s); + } + else + { + const char *q = string, *p = string; + while ( 1 ) + { + if (*p == ',' || *p == 0) + { + n++; + hts_expand(char*,n,m,s); + s[n-1] = (char*)calloc(p - q + 1, 1); + strncpy(s[n-1], q, p - q); + q = p + 1; + } + if ( !*p ) break; + p++; + } + } + s = (char**)realloc(s, n * sizeof(char*)); + *_n = n; + return s; +} + +char **hts_readlines(const char *fn, int *_n) +{ + int m = 0, n = 0, dret; + char **s = 0; +#if KS_BGZF + BGZF *fp = bgzf_open(fn, "r"); +#else + gzFile fp = gzopen(fn, "r"); +#endif + if ( fp ) { // read from file + kstream_t *ks; + kstring_t str; + str.s = 0; str.l = str.m = 0; + ks = ks_init(fp); + while (ks_getuntil(ks, KS_SEP_LINE, &str, &dret) >= 0) { + if (str.l == 0) continue; + if (m == n) { + m = m? m<<1 : 16; + s = (char**)realloc(s, m * sizeof(char*)); + } + s[n++] = strdup(str.s); + } + ks_destroy(ks); + #if KS_BGZF + bgzf_close(fp); + #else + gzclose(fp); + #endif + s = (char**)realloc(s, n * sizeof(char*)); + free(str.s); + } else if (*fn == ':') { // read from string + const char *q, *p; + for (q = p = fn + 1;; ++p) + if (*p == ',' || *p == 0) { + if (m == n) { + m = m? m<<1 : 16; + s = (char**)realloc(s, m * sizeof(char*)); + } + s[n] = (char*)calloc(p - q + 1, 1); + strncpy(s[n++], q, p - q); + q = p + 1; + if (*p == 0) break; + } + } else return 0; + s = (char**)realloc(s, n * sizeof(char*)); + *_n = n; + return s; +} + +// DEPRECATED: To be removed in a future HTSlib release +int hts_file_type(const char *fname) +{ + int len = strlen(fname); + if ( !strcasecmp(".vcf.gz",fname+len-7) ) return FT_VCF_GZ; + if ( !strcasecmp(".vcf",fname+len-4) ) return FT_VCF; + if ( !strcasecmp(".bcf",fname+len-4) ) return FT_BCF_GZ; + if ( !strcmp("-",fname) ) return FT_STDIN; + + hFILE *f = hopen(fname, "r"); + if (f == NULL) return 0; + + htsFormat fmt; + if (hts_detect_format(f, &fmt) < 0) { hclose_abruptly(f); return 0; } + if (hclose(f) < 0) return 0; + + switch (fmt.format) { + case vcf: return (fmt.compression == no_compression)? FT_VCF : FT_VCF_GZ; + case bcf: return (fmt.compression == no_compression)? FT_BCF : FT_BCF_GZ; + default: return 0; + } +} + +/**************** + *** Indexing *** + ****************/ + +#define HTS_MIN_MARKER_DIST 0x10000 + +// Finds the special meta bin +// ((1<<(3 * n_lvls + 3)) - 1) / 7 + 1 +#define META_BIN(idx) ((idx)->n_bins + 1) + +#define pair64_lt(a,b) ((a).u < (b).u) + +#include "htslib/ksort.h" +KSORT_INIT(_off, hts_pair64_t, pair64_lt) + +typedef struct { + int32_t m, n; + uint64_t loff; + hts_pair64_t *list; +} bins_t; + +#include "htslib/khash.h" +KHASH_MAP_INIT_INT(bin, bins_t) +typedef khash_t(bin) bidx_t; + +typedef struct { + int32_t n, m; + uint64_t *offset; +} lidx_t; + +struct __hts_idx_t { + int fmt, min_shift, n_lvls, n_bins; + uint32_t l_meta; + int32_t n, m; + uint64_t n_no_coor; + bidx_t **bidx; + lidx_t *lidx; + uint8_t *meta; + struct { + uint32_t last_bin, save_bin; + int last_coor, last_tid, save_tid, finished; + uint64_t last_off, save_off; + uint64_t off_beg, off_end; + uint64_t n_mapped, n_unmapped; + } z; // keep internal states +}; + +static inline void insert_to_b(bidx_t *b, int bin, uint64_t beg, uint64_t end) +{ + khint_t k; + bins_t *l; + int absent; + k = kh_put(bin, b, bin, &absent); + l = &kh_value(b, k); + if (absent) { + l->m = 1; l->n = 0; + l->list = (hts_pair64_t*)calloc(l->m, sizeof(hts_pair64_t)); + } + if (l->n == l->m) { + l->m <<= 1; + l->list = (hts_pair64_t*)realloc(l->list, l->m * sizeof(hts_pair64_t)); + } + l->list[l->n].u = beg; + l->list[l->n++].v = end; +} + +static inline void insert_to_l(lidx_t *l, int64_t _beg, int64_t _end, uint64_t offset, int min_shift) +{ + int i, beg, end; + beg = _beg >> min_shift; + end = (_end - 1) >> min_shift; + if (l->m < end + 1) { + int old_m = l->m; + l->m = end + 1; + kroundup32(l->m); + l->offset = (uint64_t*)realloc(l->offset, l->m * sizeof(uint64_t)); + memset(l->offset + old_m, 0xff, 8 * (l->m - old_m)); // fill l->offset with (uint64_t)-1 + } + if (beg == end) { // to save a loop in this case + if (l->offset[beg] == (uint64_t)-1) l->offset[beg] = offset; + } else { + for (i = beg; i <= end; ++i) + if (l->offset[i] == (uint64_t)-1) l->offset[i] = offset; + } + if (l->n < end + 1) l->n = end + 1; +} + +hts_idx_t *hts_idx_init(int n, int fmt, uint64_t offset0, int min_shift, int n_lvls) +{ + hts_idx_t *idx; + idx = (hts_idx_t*)calloc(1, sizeof(hts_idx_t)); + if (idx == NULL) return NULL; + idx->fmt = fmt; + idx->min_shift = min_shift; + idx->n_lvls = n_lvls; + idx->n_bins = ((1<<(3 * n_lvls + 3)) - 1) / 7; + idx->z.save_bin = idx->z.save_tid = idx->z.last_tid = idx->z.last_bin = 0xffffffffu; + idx->z.save_off = idx->z.last_off = idx->z.off_beg = idx->z.off_end = offset0; + idx->z.last_coor = 0xffffffffu; + if (n) { + idx->n = idx->m = n; + idx->bidx = (bidx_t**)calloc(n, sizeof(bidx_t*)); + if (idx->bidx == NULL) { free(idx); return NULL; } + idx->lidx = (lidx_t*) calloc(n, sizeof(lidx_t)); + if (idx->lidx == NULL) { free(idx->bidx); free(idx); return NULL; } + } + return idx; +} + +static void update_loff(hts_idx_t *idx, int i, int free_lidx) +{ + bidx_t *bidx = idx->bidx[i]; + lidx_t *lidx = &idx->lidx[i]; + khint_t k; + int l; + uint64_t offset0 = 0; + if (bidx) { + k = kh_get(bin, bidx, META_BIN(idx)); + if (k != kh_end(bidx)) + offset0 = kh_val(bidx, k).list[0].u; + for (l = 0; l < lidx->n && lidx->offset[l] == (uint64_t)-1; ++l) + lidx->offset[l] = offset0; + } else l = 1; + for (; l < lidx->n; ++l) // fill missing values + if (lidx->offset[l] == (uint64_t)-1) + lidx->offset[l] = lidx->offset[l-1]; + if (bidx == 0) return; + for (k = kh_begin(bidx); k != kh_end(bidx); ++k) // set loff + if (kh_exist(bidx, k)) + { + if ( kh_key(bidx, k) < idx->n_bins ) + { + int bot_bin = hts_bin_bot(kh_key(bidx, k), idx->n_lvls); + // disable linear index if bot_bin out of bounds + kh_val(bidx, k).loff = bot_bin < lidx->n ? lidx->offset[bot_bin] : 0; + } + else + kh_val(bidx, k).loff = 0; + } + if (free_lidx) { + free(lidx->offset); + lidx->m = lidx->n = 0; + lidx->offset = 0; + } +} + +static void compress_binning(hts_idx_t *idx, int i) +{ + bidx_t *bidx = idx->bidx[i]; + khint_t k; + int l, m; + if (bidx == 0) return; + // merge a bin to its parent if the bin is too small + for (l = idx->n_lvls; l > 0; --l) { + unsigned start = hts_bin_first(l); + for (k = kh_begin(bidx); k != kh_end(bidx); ++k) { + bins_t *p, *q; + if (!kh_exist(bidx, k) || kh_key(bidx, k) >= idx->n_bins || kh_key(bidx, k) < start) continue; + p = &kh_value(bidx, k); + if (l < idx->n_lvls && p->n > 1) ks_introsort(_off, p->n, p->list); + if ((p->list[p->n - 1].v>>16) - (p->list[0].u>>16) < HTS_MIN_MARKER_DIST) { + khint_t kp; + kp = kh_get(bin, bidx, hts_bin_parent(kh_key(bidx, k))); + if (kp == kh_end(bidx)) continue; + q = &kh_val(bidx, kp); + if (q->n + p->n > q->m) { + q->m = q->n + p->n; + kroundup32(q->m); + q->list = (hts_pair64_t*)realloc(q->list, q->m * sizeof(hts_pair64_t)); + } + memcpy(q->list + q->n, p->list, p->n * sizeof(hts_pair64_t)); + q->n += p->n; + free(p->list); + kh_del(bin, bidx, k); + } + } + } + k = kh_get(bin, bidx, 0); + if (k != kh_end(bidx)) ks_introsort(_off, kh_val(bidx, k).n, kh_val(bidx, k).list); + // merge adjacent chunks that start from the same BGZF block + for (k = kh_begin(bidx); k != kh_end(bidx); ++k) { + bins_t *p; + if (!kh_exist(bidx, k) || kh_key(bidx, k) >= idx->n_bins) continue; + p = &kh_value(bidx, k); + for (l = 1, m = 0; l < p->n; ++l) { + if (p->list[m].v>>16 >= p->list[l].u>>16) { + if (p->list[m].v < p->list[l].v) p->list[m].v = p->list[l].v; + } else p->list[++m] = p->list[l]; + } + p->n = m + 1; + } +} + +void hts_idx_finish(hts_idx_t *idx, uint64_t final_offset) +{ + int i; + if (idx == NULL || idx->z.finished) return; // do not run this function on an empty index or multiple times + if (idx->z.save_tid >= 0) { + insert_to_b(idx->bidx[idx->z.save_tid], idx->z.save_bin, idx->z.save_off, final_offset); + insert_to_b(idx->bidx[idx->z.save_tid], META_BIN(idx), idx->z.off_beg, final_offset); + insert_to_b(idx->bidx[idx->z.save_tid], META_BIN(idx), idx->z.n_mapped, idx->z.n_unmapped); + } + for (i = 0; i < idx->n; ++i) { + update_loff(idx, i, (idx->fmt == HTS_FMT_CSI)); + compress_binning(idx, i); + } + idx->z.finished = 1; +} + +int hts_idx_push(hts_idx_t *idx, int tid, int beg, int end, uint64_t offset, int is_mapped) +{ + int bin; + if (tid<0) beg = -1, end = 0; + if (tid >= idx->m) { // enlarge the index + int32_t oldm = idx->m; + idx->m = idx->m? idx->m<<1 : 2; + idx->bidx = (bidx_t**)realloc(idx->bidx, idx->m * sizeof(bidx_t*)); + idx->lidx = (lidx_t*) realloc(idx->lidx, idx->m * sizeof(lidx_t)); + memset(&idx->bidx[oldm], 0, (idx->m - oldm) * sizeof(bidx_t*)); + memset(&idx->lidx[oldm], 0, (idx->m - oldm) * sizeof(lidx_t)); + } + if (idx->n < tid + 1) idx->n = tid + 1; + if (idx->z.finished) return 0; + if (idx->z.last_tid != tid || (idx->z.last_tid >= 0 && tid < 0)) { // change of chromosome + if ( tid>=0 && idx->n_no_coor ) + { + if (hts_verbose >= 1) fprintf(stderr,"[E::%s] NO_COOR reads not in a single block at the end %d %d\n", __func__, tid,idx->z.last_tid); + return -1; + } + if (tid>=0 && idx->bidx[tid] != 0) + { + if (hts_verbose >= 1) fprintf(stderr, "[E::%s] chromosome blocks not continuous\n", __func__); + return -1; + } + idx->z.last_tid = tid; + idx->z.last_bin = 0xffffffffu; + } else if (tid >= 0 && idx->z.last_coor > beg) { // test if positions are out of order + if (hts_verbose >= 1) fprintf(stderr, "[E::%s] unsorted positions\n", __func__); + return -1; + } + if ( tid>=0 ) + { + if (idx->bidx[tid] == 0) idx->bidx[tid] = kh_init(bin); + if ( is_mapped) + insert_to_l(&idx->lidx[tid], beg, end, idx->z.last_off, idx->min_shift); // last_off points to the start of the current record + } + else idx->n_no_coor++; + bin = hts_reg2bin(beg, end, idx->min_shift, idx->n_lvls); + if ((int)idx->z.last_bin != bin) { // then possibly write the binning index + if (idx->z.save_bin != 0xffffffffu) // save_bin==0xffffffffu only happens to the first record + insert_to_b(idx->bidx[idx->z.save_tid], idx->z.save_bin, idx->z.save_off, idx->z.last_off); + if (idx->z.last_bin == 0xffffffffu && idx->z.save_bin != 0xffffffffu) { // change of chr; keep meta information + idx->z.off_end = idx->z.last_off; + insert_to_b(idx->bidx[idx->z.save_tid], META_BIN(idx), idx->z.off_beg, idx->z.off_end); + insert_to_b(idx->bidx[idx->z.save_tid], META_BIN(idx), idx->z.n_mapped, idx->z.n_unmapped); + idx->z.n_mapped = idx->z.n_unmapped = 0; + idx->z.off_beg = idx->z.off_end; + } + idx->z.save_off = idx->z.last_off; + idx->z.save_bin = idx->z.last_bin = bin; + idx->z.save_tid = tid; + } + if (is_mapped) ++idx->z.n_mapped; + else ++idx->z.n_unmapped; + idx->z.last_off = offset; + idx->z.last_coor = beg; + return 0; +} + +void hts_idx_destroy(hts_idx_t *idx) +{ + khint_t k; + int i; + if (idx == 0) return; + // For HTS_FMT_CRAI, idx actually points to a different type -- see sam.c + if (idx->fmt == HTS_FMT_CRAI) { free(idx); return; } + + for (i = 0; i < idx->m; ++i) { + bidx_t *bidx = idx->bidx[i]; + free(idx->lidx[i].offset); + if (bidx == 0) continue; + for (k = kh_begin(bidx); k != kh_end(bidx); ++k) + if (kh_exist(bidx, k)) + free(kh_value(bidx, k).list); + kh_destroy(bin, bidx); + } + free(idx->bidx); free(idx->lidx); free(idx->meta); + free(idx); +} + +static inline long idx_read(int is_bgzf, void *fp, void *buf, long l) +{ + if (is_bgzf) return bgzf_read((BGZF*)fp, buf, l); + else return (long)fread(buf, 1, l, (FILE*)fp); +} + +static inline long idx_write(int is_bgzf, void *fp, const void *buf, long l) +{ + if (is_bgzf) return bgzf_write((BGZF*)fp, buf, l); + else return (long)fwrite(buf, 1, l, (FILE*)fp); +} + +static inline void swap_bins(bins_t *p) +{ + int i; + for (i = 0; i < p->n; ++i) { + ed_swap_8p(&p->list[i].u); + ed_swap_8p(&p->list[i].v); + } +} + +static void hts_idx_save_core(const hts_idx_t *idx, void *fp, int fmt) +{ + int32_t i, size, is_be; + int is_bgzf = (fmt != HTS_FMT_BAI); + is_be = ed_is_big(); + if (is_be) { + uint32_t x = idx->n; + idx_write(is_bgzf, fp, ed_swap_4p(&x), 4); + } else idx_write(is_bgzf, fp, &idx->n, 4); + if (fmt == HTS_FMT_TBI && idx->l_meta) idx_write(is_bgzf, fp, idx->meta, idx->l_meta); + for (i = 0; i < idx->n; ++i) { + khint_t k; + bidx_t *bidx = idx->bidx[i]; + lidx_t *lidx = &idx->lidx[i]; + // write binning index + size = bidx? kh_size(bidx) : 0; + if (is_be) { // big endian + uint32_t x = size; + idx_write(is_bgzf, fp, ed_swap_4p(&x), 4); + } else idx_write(is_bgzf, fp, &size, 4); + if (bidx == 0) goto write_lidx; + for (k = kh_begin(bidx); k != kh_end(bidx); ++k) { + bins_t *p; + if (!kh_exist(bidx, k)) continue; + p = &kh_value(bidx, k); + if (is_be) { // big endian + uint32_t x; + x = kh_key(bidx, k); idx_write(is_bgzf, fp, ed_swap_4p(&x), 4); + if (fmt == HTS_FMT_CSI) { + uint64_t y = kh_val(bidx, k).loff; + idx_write(is_bgzf, fp, ed_swap_4p(&y), 8); + } + x = p->n; idx_write(is_bgzf, fp, ed_swap_4p(&x), 4); + swap_bins(p); + idx_write(is_bgzf, fp, p->list, 16 * p->n); + swap_bins(p); + } else { + idx_write(is_bgzf, fp, &kh_key(bidx, k), 4); + if (fmt == HTS_FMT_CSI) idx_write(is_bgzf, fp, &kh_val(bidx, k).loff, 8); + //int j;for(j=0;j<p->n;++j)fprintf(stderr,"%d,%llx,%d,%llx:%llx\n",kh_key(bidx,k),kh_val(bidx, k).loff,j,p->list[j].u,p->list[j].v); + idx_write(is_bgzf, fp, &p->n, 4); + idx_write(is_bgzf, fp, p->list, p->n << 4); + } + } +write_lidx: + if (fmt != HTS_FMT_CSI) { + if (is_be) { + int32_t x = lidx->n; + idx_write(is_bgzf, fp, ed_swap_4p(&x), 4); + for (x = 0; x < lidx->n; ++x) ed_swap_8p(&lidx->offset[x]); + idx_write(is_bgzf, fp, lidx->offset, lidx->n << 3); + for (x = 0; x < lidx->n; ++x) ed_swap_8p(&lidx->offset[x]); + } else { + idx_write(is_bgzf, fp, &lidx->n, 4); + idx_write(is_bgzf, fp, lidx->offset, lidx->n << 3); + } + } + } + if (is_be) { // write the number of reads without coordinates + uint64_t x = idx->n_no_coor; + idx_write(is_bgzf, fp, &x, 8); + } else idx_write(is_bgzf, fp, &idx->n_no_coor, 8); +} + +void hts_idx_save(const hts_idx_t *idx, const char *fn, int fmt) +{ + char *fnidx; + fnidx = (char*)calloc(1, strlen(fn) + 5); + strcpy(fnidx, fn); + if (fmt == HTS_FMT_CSI) { + BGZF *fp; + uint32_t x[3]; + int is_be, i; + is_be = ed_is_big(); + fp = bgzf_open(strcat(fnidx, ".csi"), "w"); + bgzf_write(fp, "CSI\1", 4); + x[0] = idx->min_shift; x[1] = idx->n_lvls; x[2] = idx->l_meta; + if (is_be) { + for (i = 0; i < 3; ++i) + bgzf_write(fp, ed_swap_4p(&x[i]), 4); + } else bgzf_write(fp, &x, 12); + if (idx->l_meta) bgzf_write(fp, idx->meta, idx->l_meta); + hts_idx_save_core(idx, fp, HTS_FMT_CSI); + bgzf_close(fp); + } else if (fmt == HTS_FMT_TBI) { + BGZF *fp; + fp = bgzf_open(strcat(fnidx, ".tbi"), "w"); + bgzf_write(fp, "TBI\1", 4); + hts_idx_save_core(idx, fp, HTS_FMT_TBI); + bgzf_close(fp); + } else if (fmt == HTS_FMT_BAI) { + FILE *fp; + fp = fopen(strcat(fnidx, ".bai"), "w"); + fwrite("BAI\1", 1, 4, fp); + hts_idx_save_core(idx, fp, HTS_FMT_BAI); + fclose(fp); + } else abort(); + free(fnidx); +} + +static int hts_idx_load_core(hts_idx_t *idx, void *fp, int fmt) +{ + int32_t i, n, is_be; + int is_bgzf = (fmt != HTS_FMT_BAI); + is_be = ed_is_big(); + if (idx == NULL) return -4; + for (i = 0; i < idx->n; ++i) { + bidx_t *h; + lidx_t *l = &idx->lidx[i]; + uint32_t key; + int j, absent; + bins_t *p; + h = idx->bidx[i] = kh_init(bin); + if (idx_read(is_bgzf, fp, &n, 4) != 4) return -1; + if (is_be) ed_swap_4p(&n); + for (j = 0; j < n; ++j) { + khint_t k; + if (idx_read(is_bgzf, fp, &key, 4) != 4) return -1; + if (is_be) ed_swap_4p(&key); + k = kh_put(bin, h, key, &absent); + if (absent <= 0) return -3; // Duplicate bin number + p = &kh_val(h, k); + if (fmt == HTS_FMT_CSI) { + if (idx_read(is_bgzf, fp, &p->loff, 8) != 8) return -1; + if (is_be) ed_swap_8p(&p->loff); + } else p->loff = 0; + if (idx_read(is_bgzf, fp, &p->n, 4) != 4) return -1; + if (is_be) ed_swap_4p(&p->n); + p->m = p->n; + p->list = (hts_pair64_t*)malloc(p->m * sizeof(hts_pair64_t)); + if (p->list == NULL) return -2; + if (idx_read(is_bgzf, fp, p->list, p->n<<4) != p->n<<4) return -1; + if (is_be) swap_bins(p); + } + if (fmt != HTS_FMT_CSI) { // load linear index + int j; + if (idx_read(is_bgzf, fp, &l->n, 4) != 4) return -1; + if (is_be) ed_swap_4p(&l->n); + l->m = l->n; + l->offset = (uint64_t*)malloc(l->n * sizeof(uint64_t)); + if (l->offset == NULL) return -2; + if (idx_read(is_bgzf, fp, l->offset, l->n << 3) != l->n << 3) return -1; + if (is_be) for (j = 0; j < l->n; ++j) ed_swap_8p(&l->offset[j]); + for (j = 1; j < l->n; ++j) // fill missing values; may happen given older samtools and tabix + if (l->offset[j] == 0) l->offset[j] = l->offset[j-1]; + update_loff(idx, i, 1); + } + } + if (idx_read(is_bgzf, fp, &idx->n_no_coor, 8) != 8) idx->n_no_coor = 0; + if (is_be) ed_swap_8p(&idx->n_no_coor); + return 0; +} + +hts_idx_t *hts_idx_load_local(const char *fn, int fmt) +{ + uint8_t magic[4]; + int i, is_be; + hts_idx_t *idx = NULL; + is_be = ed_is_big(); + if (fmt == HTS_FMT_CSI) { + BGZF *fp; + uint32_t x[3], n; + uint8_t *meta = 0; + if ((fp = bgzf_open(fn, "r")) == 0) return NULL; + if (bgzf_read(fp, magic, 4) != 4) goto csi_fail; + if (memcmp(magic, "CSI\1", 4) != 0) goto csi_fail; + if (bgzf_read(fp, x, 12) != 12) goto csi_fail; + if (is_be) for (i = 0; i < 3; ++i) ed_swap_4p(&x[i]); + if (x[2]) { + if ((meta = (uint8_t*)malloc(x[2])) == NULL) goto csi_fail; + if (bgzf_read(fp, meta, x[2]) != x[2]) goto csi_fail; + } + if (bgzf_read(fp, &n, 4) != 4) goto csi_fail; + if (is_be) ed_swap_4p(&n); + if ((idx = hts_idx_init(n, fmt, 0, x[0], x[1])) == NULL) goto csi_fail; + idx->l_meta = x[2]; + idx->meta = meta; + meta = NULL; + if (hts_idx_load_core(idx, fp, HTS_FMT_CSI) < 0) goto csi_fail; + bgzf_close(fp); + return idx; + + csi_fail: + bgzf_close(fp); + hts_idx_destroy(idx); + free(meta); + return NULL; + + } else if (fmt == HTS_FMT_TBI) { + BGZF *fp; + uint32_t x[8]; + if ((fp = bgzf_open(fn, "r")) == 0) return NULL; + if (bgzf_read(fp, magic, 4) != 4) goto tbi_fail; + if (memcmp(magic, "TBI\1", 4) != 0) goto tbi_fail; + if (bgzf_read(fp, x, 32) != 32) goto tbi_fail; + if (is_be) for (i = 0; i < 8; ++i) ed_swap_4p(&x[i]); + if ((idx = hts_idx_init(x[0], fmt, 0, 14, 5)) == NULL) goto tbi_fail; + idx->l_meta = 28 + x[7]; + if ((idx->meta = (uint8_t*)malloc(idx->l_meta)) == NULL) goto tbi_fail; + memcpy(idx->meta, &x[1], 28); + if (bgzf_read(fp, idx->meta + 28, x[7]) != x[7]) goto tbi_fail; + if (hts_idx_load_core(idx, fp, HTS_FMT_TBI) < 0) goto tbi_fail; + bgzf_close(fp); + return idx; + + tbi_fail: + bgzf_close(fp); + hts_idx_destroy(idx); + return NULL; + + } else if (fmt == HTS_FMT_BAI) { + uint32_t n; + FILE *fp; + if ((fp = fopen(fn, "rb")) == 0) return NULL; + if (fread(magic, 1, 4, fp) != 4) goto bai_fail; + if (memcmp(magic, "BAI\1", 4) != 0) goto bai_fail; + if (fread(&n, 4, 1, fp) != 1) goto bai_fail; + if (is_be) ed_swap_4p(&n); + idx = hts_idx_init(n, fmt, 0, 14, 5); + if (hts_idx_load_core(idx, fp, HTS_FMT_BAI) < 0) goto bai_fail; + fclose(fp); + return idx; + + bai_fail: + fclose(fp); + hts_idx_destroy(idx); + return NULL; + + } else abort(); +} + +void hts_idx_set_meta(hts_idx_t *idx, int l_meta, uint8_t *meta, int is_copy) +{ + if (idx->meta) free(idx->meta); + idx->l_meta = l_meta; + if (is_copy) { + idx->meta = (uint8_t*)malloc(l_meta); + memcpy(idx->meta, meta, l_meta); + } else idx->meta = meta; +} + +uint8_t *hts_idx_get_meta(hts_idx_t *idx, int *l_meta) +{ + *l_meta = idx->l_meta; + return idx->meta; +} + +const char **hts_idx_seqnames(const hts_idx_t *idx, int *n, hts_id2name_f getid, void *hdr) +{ + if ( !idx->n ) + { + *n = 0; + return NULL; + } + + int tid = 0, i; + const char **names = (const char**) calloc(idx->n,sizeof(const char*)); + for (i=0; i<idx->n; i++) + { + bidx_t *bidx = idx->bidx[i]; + if ( !bidx ) continue; + names[tid++] = getid(hdr,i); + } + *n = tid; + return names; +} + +int hts_idx_get_stat(const hts_idx_t* idx, int tid, uint64_t* mapped, uint64_t* unmapped) +{ + if ( idx->fmt == HTS_FMT_CRAI ) { + *mapped = 0; *unmapped = 0; + return -1; + } + + bidx_t *h = idx->bidx[tid]; + khint_t k = kh_get(bin, h, META_BIN(idx)); + if (k != kh_end(h)) { + *mapped = kh_val(h, k).list[1].u; + *unmapped = kh_val(h, k).list[1].v; + return 0; + } else { + *mapped = 0; *unmapped = 0; + return -1; + } +} + +uint64_t hts_idx_get_n_no_coor(const hts_idx_t* idx) +{ + return idx->n_no_coor; +} + +/**************** + *** Iterator *** + ****************/ + +static inline int reg2bins(int64_t beg, int64_t end, hts_itr_t *itr, int min_shift, int n_lvls) +{ + int l, t, s = min_shift + (n_lvls<<1) + n_lvls; + if (beg >= end) return 0; + if (end >= 1LL<<s) end = 1LL<<s; + for (--end, l = 0, t = 0; l <= n_lvls; s -= 3, t += 1<<((l<<1)+l), ++l) { + int b, e, n, i; + b = t + (beg>>s); e = t + (end>>s); n = e - b + 1; + if (itr->bins.n + n > itr->bins.m) { + itr->bins.m = itr->bins.n + n; + kroundup32(itr->bins.m); + itr->bins.a = (int*)realloc(itr->bins.a, sizeof(int) * itr->bins.m); + } + for (i = b; i <= e; ++i) itr->bins.a[itr->bins.n++] = i; + } + return itr->bins.n; +} + +hts_itr_t *hts_itr_query(const hts_idx_t *idx, int tid, int beg, int end, hts_readrec_func *readrec) +{ + int i, n_off, l, bin; + hts_pair64_t *off; + khint_t k; + bidx_t *bidx; + uint64_t min_off; + hts_itr_t *iter = 0; + if (tid < 0) { + int finished0 = 0; + uint64_t off0 = (uint64_t)-1; + khint_t k; + switch (tid) { + case HTS_IDX_START: + // Find the smallest offset, note that sequence ids may not be ordered sequentially + for (i=0; i<idx->n; i++) + { + bidx = idx->bidx[i]; + k = kh_get(bin, bidx, META_BIN(idx)); + if (k == kh_end(bidx)) continue; + if ( off0 > kh_val(bidx, k).list[0].u ) off0 = kh_val(bidx, k).list[0].u; + } + if ( off0==(uint64_t)-1 && idx->n_no_coor ) off0 = 0; // only no-coor reads in this bam + break; + + case HTS_IDX_NOCOOR: + if ( idx->n>0 ) + { + bidx = idx->bidx[idx->n - 1]; + k = kh_get(bin, bidx, META_BIN(idx)); + if (k != kh_end(bidx)) off0 = kh_val(bidx, k).list[0].v; + } + if ( off0==(uint64_t)-1 && idx->n_no_coor ) off0 = 0; // only no-coor reads in this bam + break; + + case HTS_IDX_REST: + off0 = 0; + break; + + case HTS_IDX_NONE: + finished0 = 1; + off0 = 0; + break; + + default: + return 0; + } + if (off0 != (uint64_t)-1) { + iter = (hts_itr_t*)calloc(1, sizeof(hts_itr_t)); + iter->read_rest = 1; + iter->finished = finished0; + iter->curr_off = off0; + iter->readrec = readrec; + return iter; + } else return 0; + } + + if (beg < 0) beg = 0; + if (end < beg) return 0; + if (tid >= idx->n || (bidx = idx->bidx[tid]) == NULL) return 0; + + iter = (hts_itr_t*)calloc(1, sizeof(hts_itr_t)); + iter->tid = tid, iter->beg = beg, iter->end = end; iter->i = -1; + iter->readrec = readrec; + + // compute min_off + bin = hts_bin_first(idx->n_lvls) + (beg>>idx->min_shift); + do { + int first; + k = kh_get(bin, bidx, bin); + if (k != kh_end(bidx)) break; + first = (hts_bin_parent(bin)<<3) + 1; + if (bin > first) --bin; + else bin = hts_bin_parent(bin); + } while (bin); + if (bin == 0) k = kh_get(bin, bidx, bin); + min_off = k != kh_end(bidx)? kh_val(bidx, k).loff : 0; + // retrieve bins + reg2bins(beg, end, iter, idx->min_shift, idx->n_lvls); + for (i = n_off = 0; i < iter->bins.n; ++i) + if ((k = kh_get(bin, bidx, iter->bins.a[i])) != kh_end(bidx)) + n_off += kh_value(bidx, k).n; + if (n_off == 0) return iter; + off = (hts_pair64_t*)calloc(n_off, sizeof(hts_pair64_t)); + for (i = n_off = 0; i < iter->bins.n; ++i) { + if ((k = kh_get(bin, bidx, iter->bins.a[i])) != kh_end(bidx)) { + int j; + bins_t *p = &kh_value(bidx, k); + for (j = 0; j < p->n; ++j) + if (p->list[j].v > min_off) off[n_off++] = p->list[j]; + } + } + if (n_off == 0) { + free(off); return iter; + } + ks_introsort(_off, n_off, off); + // resolve completely contained adjacent blocks + for (i = 1, l = 0; i < n_off; ++i) + if (off[l].v < off[i].v) off[++l] = off[i]; + n_off = l + 1; + // resolve overlaps between adjacent blocks; this may happen due to the merge in indexing + for (i = 1; i < n_off; ++i) + if (off[i-1].v >= off[i].u) off[i-1].v = off[i].u; + // merge adjacent blocks + for (i = 1, l = 0; i < n_off; ++i) { + if (off[l].v>>16 == off[i].u>>16) off[l].v = off[i].v; + else off[++l] = off[i]; + } + n_off = l + 1; + iter->n_off = n_off; iter->off = off; + return iter; +} + +void hts_itr_destroy(hts_itr_t *iter) +{ + if (iter) { free(iter->off); free(iter->bins.a); free(iter); } +} + +const char *hts_parse_reg(const char *s, int *beg, int *end) +{ + int i, k, l, name_end; + *beg = *end = -1; + name_end = l = strlen(s); + // determine the sequence name + for (i = l - 1; i >= 0; --i) if (s[i] == ':') break; // look for colon from the end + if (i >= 0) name_end = i; + if (name_end < l) { // check if this is really the end + int n_hyphen = 0; + for (i = name_end + 1; i < l; ++i) { + if (s[i] == '-') ++n_hyphen; + else if (!isdigit(s[i]) && s[i] != ',') break; + } + if (i < l || n_hyphen > 1) name_end = l; // malformated region string; then take str as the name + } + // parse the interval + if (name_end < l) { + char *tmp; + tmp = (char*)alloca(l - name_end + 1); + for (i = name_end + 1, k = 0; i < l; ++i) + if (s[i] != ',') tmp[k++] = s[i]; + tmp[k] = 0; + if ((*beg = strtol(tmp, &tmp, 10) - 1) < 0) *beg = 0; + *end = *tmp? strtol(tmp + 1, &tmp, 10) : INT_MAX; + if (*beg > *end) name_end = l; + } + if (name_end == l) *beg = 0, *end = INT_MAX; + return s + name_end; +} + +hts_itr_t *hts_itr_querys(const hts_idx_t *idx, const char *reg, hts_name2id_f getid, void *hdr, hts_itr_query_func *itr_query, hts_readrec_func *readrec) +{ + int tid, beg, end; + char *q, *tmp; + if (strcmp(reg, ".") == 0) + return itr_query(idx, HTS_IDX_START, 0, 0, readrec); + else if (strcmp(reg, "*") != 0) { + q = (char*)hts_parse_reg(reg, &beg, &end); + tmp = (char*)alloca(q - reg + 1); + strncpy(tmp, reg, q - reg); + tmp[q - reg] = 0; + if ((tid = getid(hdr, tmp)) < 0) + tid = getid(hdr, reg); + if (tid < 0) return 0; + return itr_query(idx, tid, beg, end, readrec); + } else return itr_query(idx, HTS_IDX_NOCOOR, 0, 0, readrec); +} + +int hts_itr_next(BGZF *fp, hts_itr_t *iter, void *r, void *data) +{ + int ret, tid, beg, end; + if (iter == NULL || iter->finished) return -1; + if (iter->read_rest) { + if (iter->curr_off) { // seek to the start + bgzf_seek(fp, iter->curr_off, SEEK_SET); + iter->curr_off = 0; // only seek once + } + ret = iter->readrec(fp, data, r, &tid, &beg, &end); + if (ret < 0) iter->finished = 1; + iter->curr_tid = tid; + iter->curr_beg = beg; + iter->curr_end = end; + return ret; + } + if (iter->off == 0) return -1; + for (;;) { + if (iter->curr_off == 0 || iter->curr_off >= iter->off[iter->i].v) { // then jump to the next chunk + if (iter->i == iter->n_off - 1) { ret = -1; break; } // no more chunks + if (iter->i < 0 || iter->off[iter->i].v != iter->off[iter->i+1].u) { // not adjacent chunks; then seek + bgzf_seek(fp, iter->off[iter->i+1].u, SEEK_SET); + iter->curr_off = bgzf_tell(fp); + } + ++iter->i; + } + if ((ret = iter->readrec(fp, data, r, &tid, &beg, &end)) >= 0) { + iter->curr_off = bgzf_tell(fp); + if (tid != iter->tid || beg >= iter->end) { // no need to proceed + ret = -1; break; + } else if (end > iter->beg && iter->end > beg) { + iter->curr_tid = tid; + iter->curr_beg = beg; + iter->curr_end = end; + return ret; + } + } else break; // end of file or error + } + iter->finished = 1; + return ret; +} + +/********************** + *** Retrieve index *** + **********************/ + +static char *test_and_fetch(const char *fn) +{ + FILE *fp; + if (hisremote(fn)) { + const int buf_size = 1 * 1024 * 1024; + hFILE *fp_remote; + uint8_t *buf; + int l; + const char *p; + for (p = fn + strlen(fn) - 1; p >= fn; --p) + if (*p == '/') break; + ++p; // p now points to the local file name + // Attempt to open local file first + if ((fp = fopen((char*)p, "rb")) != 0) + { + fclose(fp); + return (char*)p; + } + // Attempt to open remote file. Stay quiet on failure, it is OK to fail when trying first .csi then .tbi index. + if ((fp_remote = hopen(fn, "r")) == 0) return 0; + if ((fp = fopen(p, "w")) == 0) { + if (hts_verbose >= 1) fprintf(stderr, "[E::%s] fail to create file '%s' in the working directory\n", __func__, p); + hclose_abruptly(fp_remote); + return 0; + } + if (hts_verbose >= 3) fprintf(stderr, "[M::%s] downloading file '%s' to local directory\n", __func__, fn); + buf = (uint8_t*)calloc(buf_size, 1); + while ((l = hread(fp_remote, buf, buf_size)) > 0) fwrite(buf, 1, l, fp); + free(buf); + fclose(fp); + if (hclose(fp_remote) != 0) fprintf(stderr, "[E::%s] fail to close remote file '%s'\n", __func__, fn); + return (char*)p; + } else { + if ((fp = fopen(fn, "rb")) == 0) return 0; + fclose(fp); + return (char*)fn; + } +} + +char *hts_idx_getfn(const char *fn, const char *ext) +{ + int i, l_fn, l_ext; + char *fnidx, *ret; + l_fn = strlen(fn); l_ext = strlen(ext); + fnidx = (char*)calloc(l_fn + l_ext + 1, 1); + strcpy(fnidx, fn); strcpy(fnidx + l_fn, ext); + if ((ret = test_and_fetch(fnidx)) == 0) { + for (i = l_fn - 1; i > 0; --i) + if (fnidx[i] == '.') break; + strcpy(fnidx + i, ext); + ret = test_and_fetch(fnidx); + } + if (ret == 0) { + free(fnidx); + return 0; + } + l_fn = strlen(ret); + memmove(fnidx, ret, l_fn + 1); + return fnidx; +} + +hts_idx_t *hts_idx_load(const char *fn, int fmt) +{ + char *fnidx; + hts_idx_t *idx; + fnidx = hts_idx_getfn(fn, ".csi"); + if (fnidx) fmt = HTS_FMT_CSI; + else fnidx = hts_idx_getfn(fn, fmt == HTS_FMT_BAI? ".bai" : ".tbi"); + if (fnidx == 0) return 0; + + // Check that the index file is up to date, the main file might have changed + struct stat stat_idx,stat_main; + if ( !stat(fn, &stat_main) && !stat(fnidx, &stat_idx) ) + { + if ( stat_idx.st_mtime < stat_main.st_mtime ) + fprintf(stderr, "Warning: The index file is older than the data file: %s\n", fnidx); + } + idx = hts_idx_load_local(fnidx, fmt); + free(fnidx); + return idx; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htsfile.1 Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,71 @@ +.TH htsfile 1 "3 February 2015" "htslib-1.2.1" "Bioinformatics tools" +.SH NAME +htsfile \- identify high-throughput sequencing data files +.\" +.\" Copyright (C) 2015 Genome Research Ltd. +.\" +.\" Author: John Marshall <jm18@sanger.ac.uk> +.\" +.\" Permission is hereby granted, free of charge, to any person obtaining a +.\" copy of this software and associated documentation files (the "Software"), +.\" to deal in the Software without restriction, including without limitation +.\" the rights to use, copy, modify, merge, publish, distribute, sublicense, +.\" and/or sell copies of the Software, and to permit persons to whom the +.\" Software is furnished to do so, subject to the following conditions: +.\" +.\" The above copyright notice and this permission notice shall be included in +.\" all copies or substantial portions of the Software. +.\" +.\" THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +.\" IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +.\" FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +.\" THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +.\" LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +.\" FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +.\" DEALINGS IN THE SOFTWARE. +.\" +.SH SYNOPSIS +.B htsfile +.RB [ -chH ] +.IR FILE ... +.SH DESCRIPTION +The \fBhtsfile\fR utility attempts to identify what kind of high-throughput +sequencing data files the specified files are, and provides minimal viewing +capabilities for some kinds of data file. +.P +It can identify sequencing data files such as SAM, BAM, and CRAM; +variant calling data files such as VCF and BCF; +index files used to index these data files; +and compressed versions of many of them. +.P +For each \fIFILE\fR given, \fBhtsfile\fP prints a description of the file +format determined, using similar keyword conventions to \fBfile\fP(1): +"text" indicates a textual file that can probably be viewed on a terminal; +"data" indicates binary data; +"sequence", "variant calling", and "index" indicate different categories of +data file. +When it can be identified, the name of the particular file format (such as +"BAM" or "VCF") is printed at the start of the description. +.P +When used to view file contents as text, \fBhtsfile\fP can optionally show +only headers or only data records, but has no other filtering capabilities. +Use \fBsamtools\fR or \fBbcftools\fR if you need more extensive viewing or +filtering capabilities. +.P +The following options are accepted: +.TP 4n +.BR -c ", " --view +Instead of identifying the specified files, display a textual representation +of their contents on standard output. +.TP +.BR -h ", " --header-only +Display data file headers only. +Implies \fB--view\fR. +.TP +.BR -H ", " --no-header +When viewing files, display data records only. +.PP +.SH SEE ALSO +.IR bcftools (1), +.IR file (1), +.IR samtools (1)
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htsfile.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,168 @@ +/* htsfile.c -- file identifier and minimal viewer. + + Copyright (C) 2014-2015 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <errno.h> +#include <stdio.h> +#include <stdlib.h> +#include <getopt.h> +#include <unistd.h> + +#include "htslib/hfile.h" +#include "htslib/hts.h" +#include "htslib/sam.h" +#include "htslib/vcf.h" + +enum { identify, view_headers, view_all } mode = identify; +int show_headers = 1; + +static htsFile *dup_stdout(const char *mode) +{ + int fd = dup(STDOUT_FILENO); + hFILE *hfp = (fd >= 0)? hdopen(fd, mode) : NULL; + return hfp? hts_hopen(hfp, "-", mode) : NULL; +} + +static int view_sam(hFILE *hfp, const char *filename) +{ + samFile *in = hts_hopen(hfp, filename, "r"); + if (in == NULL) return 0; + samFile *out = dup_stdout("w"); + bam_hdr_t *hdr = sam_hdr_read(in); + + if (show_headers) sam_hdr_write(out, hdr); + if (mode == view_all) { + bam1_t *b = bam_init1(); + while (sam_read1(in, hdr, b) >= 0) + sam_write1(out, hdr, b); + bam_destroy1(b); + } + + bam_hdr_destroy(hdr); + hts_close(out); + hts_close(in); + return 1; +} + +static int view_vcf(hFILE *hfp, const char *filename) +{ + vcfFile *in = hts_hopen(hfp, filename, "r"); + if (in == NULL) return 0; + vcfFile *out = dup_stdout("w"); + bcf_hdr_t *hdr = bcf_hdr_read(in); + + if (show_headers) bcf_hdr_write(out, hdr); + if (mode == view_all) { + bcf1_t *rec = bcf_init(); + while (bcf_read(in, hdr, rec) >= 0) + bcf_write(out, hdr, rec); + bcf_destroy(rec); + } + + bcf_hdr_destroy(hdr); + hts_close(out); + hts_close(in); + return 1; +} + +static void usage(FILE *fp, int status) +{ + fprintf(fp, +"Usage: htsfile [-chH] FILE...\n" +"Options:\n" +" -c, --view Write textual form of FILEs to standard output\n" +" -h, --header-only Display only headers in view mode, not records\n" +" -H, --no-header Suppress header display in view mode\n"); + exit(status); +} + +int main(int argc, char **argv) +{ + static const struct option options[] = { + { "header-only", no_argument, NULL, 'h' }, + { "no-header", no_argument, NULL, 'H' }, + { "view", no_argument, NULL, 'c' }, + { "help", no_argument, NULL, '?' }, + { "version", no_argument, NULL, 1 }, + { NULL, 0, NULL, 0 } + }; + + int status = EXIT_SUCCESS; + int c, i; + while ((c = getopt_long(argc, argv, "chH?", options, NULL)) >= 0) + switch (c) { + case 'c': mode = view_all; break; + case 'h': mode = view_headers; show_headers = 1; break; + case 'H': show_headers = 0; break; + case 1: + printf( +"htsfile (htslib) %s\n" +"Copyright (C) 2015 Genome Research Ltd.\n", + hts_version()); + exit(EXIT_SUCCESS); + break; + case '?': usage(stdout, EXIT_SUCCESS); break; + default: usage(stderr, EXIT_FAILURE); break; + } + + if (optind == argc) usage(stderr, EXIT_FAILURE); + + for (i = optind; i < argc; i++) { + htsFormat fmt; + hFILE *fp = hopen(argv[i], "r"); + if (fp == NULL) { + fprintf(stderr, "htsfile: can't open \"%s\": %s\n", argv[i], strerror(errno)); + status = EXIT_FAILURE; + continue; + } + + if (hts_detect_format(fp, &fmt) < 0) { + fprintf(stderr, "htsfile: detecting \"%s\" format failed: %s\n", argv[i], strerror(errno)); + hclose_abruptly(fp); + status = EXIT_FAILURE; + continue; + } + + if (mode == identify) { + char *description = hts_format_description(&fmt); + printf("%s:\t%s\n", argv[i], description); + free(description); + } + else + switch (fmt.category) { + case sequence_data: if (view_sam(fp, argv[i])) fp = NULL; break; + case variant_data: if (view_vcf(fp, argv[i])) fp = NULL; break; + default: + fprintf(stderr, "htsfile: can't view %s: unknown format\n", argv[i]); + status = EXIT_FAILURE; + break; + } + + if (fp && hclose(fp) < 0) { + fprintf(stderr, "htsfile: closing %s failed\n", argv[i]); + status = EXIT_FAILURE; + } + } + + return status; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib.mk Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,150 @@ +# Makefile rules useful for third-party code using htslib's public API. +# +# Copyright (C) 2013-2015 Genome Research Ltd. +# +# Author: John Marshall <jm18@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +# The makefile fragment included below provides variables that can be used +# to express dependencies on headers supplied by an in-development htslib. +# If your source file foo.c #includes <htslib/hts.h> and <htslib/kstring.h>, +# you can write the correct prerequisites for foo.o as: +# +# HTSDIR = <path to htslib top-level directory> +# include $(HTSDIR)/htslib.mk +# +# foo.o: foo.c $(htslib_hts_h) $(HTSDIR)/htslib/kstring.h +# +# Variables are not provided for k*.h, as those never include other headers. + +HTSPREFIX = $(HTSDIR)/ +include $(HTSDIR)/htslib_vars.mk + +# Rules for rebuilding an in-development htslib's static and shared libraries. +# If your program foo links with libhts, adding the appropriate prerequisite +# will cause the library to be rebuilt as necessary: +# +# foo: foo.o $(HTSDIR)/libhts.a +# +# or similarly if your target requires any of the tools supplied: +# +# bar.bed.bgz.tbi: bar.bed.bgz $(HTSDIR)/tabix +# $(HTSDIR)/tabix -p bed bar.bed.bgz + +HTSLIB_PUBLIC_HEADERS = \ + $(HTSDIR)/htslib/bgzf.h \ + $(HTSDIR)/htslib/faidx.h \ + $(HTSDIR)/htslib/hfile.h \ + $(HTSDIR)/htslib/hts.h \ + $(HTSDIR)/htslib/hts_defs.h \ + $(HTSDIR)/htslib/khash.h \ + $(HTSDIR)/htslib/klist.h \ + $(HTSDIR)/htslib/knetfile.h \ + $(HTSDIR)/htslib/kseq.h \ + $(HTSDIR)/htslib/ksort.h \ + $(HTSDIR)/htslib/kstring.h \ + $(HTSDIR)/htslib/regidx.h \ + $(HTSDIR)/htslib/sam.h \ + $(HTSDIR)/htslib/synced_bcf_reader.h \ + $(HTSDIR)/htslib/tbx.h \ + $(HTSDIR)/htslib/vcf.h \ + $(HTSDIR)/htslib/vcf_sweep.h \ + $(HTSDIR)/htslib/vcfutils.h + +HTSLIB_ALL = \ + $(HTSLIB_PUBLIC_HEADERS) \ + $(HTSDIR)/bgzf.c \ + $(HTSDIR)/faidx.c \ + $(HTSDIR)/hfile_internal.h \ + $(HTSDIR)/hfile.c \ + $(HTSDIR)/hfile_irods.c \ + $(HTSDIR)/hfile_net.c \ + $(HTSDIR)/hts.c \ + $(HTSDIR)/knetfile.c \ + $(HTSDIR)/kstring.c \ + $(HTSDIR)/regidx.c \ + $(HTSDIR)/sam.c \ + $(HTSDIR)/synced_bcf_reader.c \ + $(HTSDIR)/tbx.c \ + $(HTSDIR)/vcf.c \ + $(HTSDIR)/vcf_sweep.c \ + $(HTSDIR)/vcfutils.c \ + $(HTSDIR)/cram/cram.h \ + $(HTSDIR)/cram/cram_codecs.c \ + $(HTSDIR)/cram/cram_codecs.h \ + $(HTSDIR)/cram/cram_decode.c \ + $(HTSDIR)/cram/cram_decode.h \ + $(HTSDIR)/cram/cram_encode.c \ + $(HTSDIR)/cram/cram_encode.h \ + $(HTSDIR)/cram/cram_index.c \ + $(HTSDIR)/cram/cram_index.h \ + $(HTSDIR)/cram/cram_io.c \ + $(HTSDIR)/cram/cram_io.h \ + $(HTSDIR)/cram/cram_samtools.c \ + $(HTSDIR)/cram/cram_samtools.h \ + $(HTSDIR)/cram/cram_stats.c \ + $(HTSDIR)/cram/cram_stats.h \ + $(HTSDIR)/cram/cram_structs.h \ + $(HTSDIR)/cram/files.c \ + $(HTSDIR)/cram/mFILE.c \ + $(HTSDIR)/cram/mFILE.h \ + $(HTSDIR)/cram/md5.c \ + $(HTSDIR)/cram/md5.h \ + $(HTSDIR)/cram/misc.h \ + $(HTSDIR)/cram/open_trace_file.c \ + $(HTSDIR)/cram/open_trace_file.h \ + $(HTSDIR)/cram/os.h \ + $(HTSDIR)/cram/pooled_alloc.c \ + $(HTSDIR)/cram/pooled_alloc.h \ + $(HTSDIR)/cram/sam_header.c \ + $(HTSDIR)/cram/sam_header.h \ + $(HTSDIR)/cram/string_alloc.c \ + $(HTSDIR)/cram/string_alloc.h \ + $(HTSDIR)/cram/thread_pool.c \ + $(HTSDIR)/cram/thread_pool.h \ + $(HTSDIR)/cram/vlen.c \ + $(HTSDIR)/cram/vlen.h \ + $(HTSDIR)/cram/zfio.c \ + $(HTSDIR)/cram/zfio.h + +$(HTSDIR)/libhts.a: $(HTSLIB_ALL) + +cd $(HTSDIR) && $(MAKE) lib-static + +$(HTSDIR)/libhts.so $(HTSDIR)/libhts.dylib: $(HTSLIB_ALL) + +cd $(HTSDIR) && $(MAKE) lib-shared + +$(HTSDIR)/bgzip: $(HTSDIR)/bgzip.c $(HTSLIB_PUBLIC_HEADERS) + +cd $(HTSDIR) && $(MAKE) bgzip + +$(HTSDIR)/htsfile: $(HTSDIR)/htsfile.c $(HTSLIB_PUBLIC_HEADERS) + +cd $(HTSDIR) && $(MAKE) htsfile + +$(HTSDIR)/tabix: $(HTSDIR)/tabix.c $(HTSLIB_PUBLIC_HEADERS) + +cd $(HTSDIR) && $(MAKE) tabix + +# Rules for phony targets. You may wish to have your corresponding phony +# targets invoke these in addition to their own recipes: +# +# clean: clean-htslib + +clean-htslib install-htslib: + +cd $(HTSDIR) && $(MAKE) $(@:-htslib=) + +.PHONY: clean-htslib install-htslib
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib.pc.in Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,10 @@ +includedir=@includedir@ +libdir=@libdir@ + +Name: htslib +Description: C library for high-throughput sequencing data formats +Version: @PACKAGE_VERSION@ +Cflags: -I${includedir} +Libs: -L${libdir} -lhts +Libs.private: -L${libdir} -lhts -lm -lpthread +Requires.private: zlib
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/bgzf.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,315 @@ +/* The MIT License + + Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology + 2011, 2012 Attractive Chaos <attractor@live.co.uk> + Copyright (C) 2009, 2013, 2014 Genome Research Ltd + + Permission is hereby granted, free of charge, to any person obtaining a copy + of this software and associated documentation files (the "Software"), to deal + in the Software without restriction, including without limitation the rights + to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + copies of the Software, and to permit persons to whom the Software is + furnished to do so, subject to the following conditions: + + The above copyright notice and this permission notice shall be included in + all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + THE SOFTWARE. +*/ + +/* The BGZF library was originally written by Bob Handsaker from the Broad + * Institute. It was later improved by the SAMtools developers. */ + +#ifndef HTSLIB_BGZF_H +#define HTSLIB_BGZF_H + +#include <stdint.h> +#include <stdio.h> +#include <zlib.h> +#include <sys/types.h> + +#define BGZF_BLOCK_SIZE 0xff00 // make sure compressBound(BGZF_BLOCK_SIZE) < BGZF_MAX_BLOCK_SIZE +#define BGZF_MAX_BLOCK_SIZE 0x10000 + +#define BGZF_ERR_ZLIB 1 +#define BGZF_ERR_HEADER 2 +#define BGZF_ERR_IO 4 +#define BGZF_ERR_MISUSE 8 + +struct hFILE; +struct bgzf_mtaux_t; +typedef struct __bgzidx_t bgzidx_t; + +struct BGZF { + int errcode:16, is_write:2, is_be:2, compress_level:9, is_compressed:2, is_gzip:1; + int cache_size; + int block_length, block_offset; + int64_t block_address, uncompressed_address; + void *uncompressed_block, *compressed_block; + void *cache; // a pointer to a hash table + struct hFILE *fp; // actual file handle + struct bgzf_mtaux_t *mt; // only used for multi-threading + bgzidx_t *idx; // BGZF index + int idx_build_otf; // build index on the fly, set by bgzf_index_build_init() + z_stream *gz_stream;// for gzip-compressed files +}; +#ifndef HTS_BGZF_TYPEDEF +typedef struct BGZF BGZF; +#define HTS_BGZF_TYPEDEF +#endif + +#ifndef KSTRING_T +#define KSTRING_T kstring_t +typedef struct __kstring_t { + size_t l, m; + char *s; +} kstring_t; +#endif + +#ifdef __cplusplus +extern "C" { +#endif + + /****************** + * Basic routines * + ******************/ + + /** + * Open an existing file descriptor for reading or writing. + * + * @param fd file descriptor + * @param mode mode matching /[rwag][u0-9]+/: 'r' for reading, 'w' for + * writing, 'a' for appending, 'g' for gzip rather than BGZF + * compression (with 'w' only), and digit specifies the zlib + * compression level. + * Note that there is a distinction between 'u' and '0': the + * first yields plain uncompressed output whereas the latter + * outputs uncompressed data wrapped in the zlib format. + * @return BGZF file handler; 0 on error + */ + BGZF* bgzf_dopen(int fd, const char *mode); + + #define bgzf_fdopen(fd, mode) bgzf_dopen((fd), (mode)) // for backward compatibility + + /** + * Open the specified file for reading or writing. + */ + BGZF* bgzf_open(const char* path, const char *mode); + + /** + * Open an existing hFILE stream for reading or writing. + */ + BGZF* bgzf_hopen(struct hFILE *fp, const char *mode); + + /** + * Close the BGZF and free all associated resources. + * + * @param fp BGZF file handler + * @return 0 on success and -1 on error + */ + int bgzf_close(BGZF *fp); + + /** + * Read up to _length_ bytes from the file storing into _data_. + * + * @param fp BGZF file handler + * @param data data array to read into + * @param length size of data to read + * @return number of bytes actually read; 0 on end-of-file and -1 on error + */ + ssize_t bgzf_read(BGZF *fp, void *data, size_t length); + + /** + * Write _length_ bytes from _data_ to the file. If no I/O errors occur, + * the complete _length_ bytes will be written (or queued for writing). + * + * @param fp BGZF file handler + * @param data data array to write + * @param length size of data to write + * @return number of bytes written (i.e., _length_); negative on error + */ + ssize_t bgzf_write(BGZF *fp, const void *data, size_t length); + + /** + * Read up to _length_ bytes directly from the underlying stream without + * decompressing. Bypasses BGZF blocking, so must be used with care in + * specialised circumstances only. + * + * @param fp BGZF file handler + * @param data data array to read into + * @param length number of raw bytes to read + * @return number of bytes actually read; 0 on end-of-file and -1 on error + */ + ssize_t bgzf_raw_read(BGZF *fp, void *data, size_t length); + + /** + * Write _length_ bytes directly to the underlying stream without + * compressing. Bypasses BGZF blocking, so must be used with care + * in specialised circumstances only. + * + * @param fp BGZF file handler + * @param data data array to write + * @param length number of raw bytes to write + * @return number of bytes actually written; -1 on error + */ + ssize_t bgzf_raw_write(BGZF *fp, const void *data, size_t length); + + /** + * Write the data in the buffer to the file. + */ + int bgzf_flush(BGZF *fp); + + /** + * Return a virtual file pointer to the current location in the file. + * No interpetation of the value should be made, other than a subsequent + * call to bgzf_seek can be used to position the file at the same point. + * Return value is non-negative on success. + */ + #define bgzf_tell(fp) (((fp)->block_address << 16) | ((fp)->block_offset & 0xFFFF)) + + /** + * Set the file to read from the location specified by _pos_. + * + * @param fp BGZF file handler + * @param pos virtual file offset returned by bgzf_tell() + * @param whence must be SEEK_SET + * @return 0 on success and -1 on error + */ + int64_t bgzf_seek(BGZF *fp, int64_t pos, int whence); + + /** + * Check if the BGZF end-of-file (EOF) marker is present + * + * @param fp BGZF file handler opened for reading + * @return 1 if the EOF marker is present and correct; + * 2 if it can't be checked, e.g., because fp isn't seekable; + * 0 if the EOF marker is absent; + * -1 (with errno set) on error + */ + int bgzf_check_EOF(BGZF *fp); + + /** + * Check if a file is in the BGZF format + * + * @param fn file name + * @return 1 if _fn_ is BGZF; 0 if not or on I/O error + */ + int bgzf_is_bgzf(const char *fn); + + /********************* + * Advanced routines * + *********************/ + + /** + * Set the cache size. Only effective when compiled with -DBGZF_CACHE. + * + * @param fp BGZF file handler + * @param size size of cache in bytes; 0 to disable caching (default) + */ + void bgzf_set_cache_size(BGZF *fp, int size); + + /** + * Flush the file if the remaining buffer size is smaller than _size_ + * @return 0 if flushing succeeded or was not needed; negative on error + */ + int bgzf_flush_try(BGZF *fp, ssize_t size); + + /** + * Read one byte from a BGZF file. It is faster than bgzf_read() + * @param fp BGZF file handler + * @return byte read; -1 on end-of-file or error + */ + int bgzf_getc(BGZF *fp); + + /** + * Read one line from a BGZF file. It is faster than bgzf_getc() + * + * @param fp BGZF file handler + * @param delim delimitor + * @param str string to write to; must be initialized + * @return length of the string; 0 on end-of-file; negative on error + */ + int bgzf_getline(BGZF *fp, int delim, kstring_t *str); + + /** + * Read the next BGZF block. + */ + int bgzf_read_block(BGZF *fp); + + /** + * Enable multi-threading (only effective on writing and when the + * library was compiled with -DBGZF_MT) + * + * @param fp BGZF file handler; must be opened for writing + * @param n_threads #threads used for writing + * @param n_sub_blks #blocks processed by each thread; a value 64-256 is recommended + */ + int bgzf_mt(BGZF *fp, int n_threads, int n_sub_blks); + + + /******************* + * bgzidx routines * + *******************/ + + /** + * Position BGZF at the uncompressed offset + * + * @param fp BGZF file handler; must be opened for reading + * @param uoffset file offset in the uncompressed data + * @param where SEEK_SET supported atm + * + * Returns 0 on success and -1 on error. + */ + int bgzf_useek(BGZF *fp, long uoffset, int where); + + /** + * Position in uncompressed BGZF + * + * @param fp BGZF file handler; must be opened for reading + * + * Returns the current offset on success and -1 on error. + */ + long bgzf_utell(BGZF *fp); + + /** + * Tell BGZF to build index while compressing. + * + * @param fp BGZF file handler; can be opened for reading or writing. + * + * Returns 0 on success and -1 on error. + */ + int bgzf_index_build_init(BGZF *fp); + + /** + * Load BGZF index + * + * @param fp BGZF file handler + * @param bname base name + * @param suffix suffix to add to bname (can be NULL) + * + * Returns 0 on success and -1 on error. + */ + int bgzf_index_load(BGZF *fp, const char *bname, const char *suffix); + + /** + * Save BGZF index + * + * @param fp BGZF file handler + * @param bname base name + * @param suffix suffix to add to bname (can be NULL) + * + * Returns 0 on success and -1 on error. + */ + int bgzf_index_dump(BGZF *fp, const char *bname, const char *suffix); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/faidx.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,135 @@ +/* faidx.h -- FASTA random access. + + Copyright (C) 2008, 2009, 2013, 2014 Genome Research Ltd. + + Author: Heng Li <lh3@sanger.ac.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +#ifndef HTSLIB_FAIDX_H +#define HTSLIB_FAIDX_H + +/*! + @header + + Index FASTA files and extract subsequence. + + The fai file index columns are: + - chromosome name + - chromosome length: number of bases + - offset: number of bytes to skip to get to the first base + from the beginning of the file, including the length + of the sequence description string (">chr ..\n") + - line length: number of bases per line (excluding \n) + - binary line length: number of bytes, including \n + + @copyright The Wellcome Trust Sanger Institute. + */ + +struct __faidx_t; +typedef struct __faidx_t faidx_t; + +#ifdef __cplusplus +extern "C" { +#endif + + /*! + @abstract Build index for a FASTA or bgzip-compressed FASTA file. + @param fn FASTA file name + @return 0 on success; or -1 on failure + @discussion File "fn.fai" will be generated. + */ + int fai_build(const char *fn); + + /*! + @abstract Destroy a faidx_t struct. + @param fai Pointer to the struct to be destroyed + */ + void fai_destroy(faidx_t *fai); + + /*! + @abstract Load index from "fn.fai". + @param fn File name of the FASTA file + */ + faidx_t *fai_load(const char *fn); + + /*! + @abstract Fetch the sequence in a region. + @param fai Pointer to the faidx_t struct + @param reg Region in the format "chr2:20,000-30,000" + @param len Length of the region; -2 if seq not present, -1 general error + @return Pointer to the sequence; null on failure + + @discussion The returned sequence is allocated by malloc family + and should be destroyed by end users by calling free() on it. + */ + char *fai_fetch(const faidx_t *fai, const char *reg, int *len); + + /*! + @abstract Fetch the number of sequences. + @param fai Pointer to the faidx_t struct + @return The number of sequences + */ + int faidx_fetch_nseq(const faidx_t *fai); + + /*! + @abstract Fetch the sequence in a region. + @param fai Pointer to the faidx_t struct + @param c_name Region name + @param p_beg_i Beginning position number (zero-based) + @param p_end_i End position number (zero-based) + @param len Length of the region; -2 if c_name not present, -1 general error + @return Pointer to the sequence; null on failure + + @discussion The returned sequence is allocated by malloc family + and should be destroyed by end users by calling free() on it. + */ + char *faidx_fetch_seq(const faidx_t *fai, const char *c_name, int p_beg_i, int p_end_i, int *len); + + /*! + @abstract Query if sequence is present + @param fai Pointer to the faidx_t struct + @param seq Sequence name + @return 1 if present or 0 if absent + */ + int faidx_has_seq(const faidx_t *fai, const char *seq); + + /*! + @abstract Return number of sequences in fai index + */ + int faidx_nseq(const faidx_t *fai); + + /*! + @abstract Return name of i-th sequence + */ + const char *faidx_iseq(const faidx_t *fai, int i); + + /*! + @abstract Return sequence length, -1 if not present + */ + int faidx_seq_len(const faidx_t *fai, const char *seq); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/hfile.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,212 @@ +/* hfile.h -- buffered low-level input/output streams. + + Copyright (C) 2013-2015 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_HFILE_H +#define HTSLIB_HFILE_H + +#include <string.h> + +#include <sys/types.h> + +#include "hts_defs.h" + +#ifdef __cplusplus +extern "C" { +#endif + +/* These fields are declared here solely for the benefit of the inline functions + below. They may change in future releases. User code should not use them + directly; you should imagine that hFILE is an opaque incomplete type. */ +struct hFILE_backend; +typedef struct hFILE { + char *buffer, *begin, *end, *limit; + const struct hFILE_backend *backend; + off_t offset; + int at_eof:1; + int has_errno; +} hFILE; + +/*! + @abstract Open the named file or URL as a stream + @return An hFILE pointer, or NULL (with errno set) if an error occurred. +*/ +hFILE *hopen(const char *filename, const char *mode) HTS_RESULT_USED; + +/*! + @abstract Associate a stream with an existing open file descriptor + @return An hFILE pointer, or NULL (with errno set) if an error occurred. + @notes For socket descriptors (on Windows), mode should contain 's'. +*/ +hFILE *hdopen(int fd, const char *mode) HTS_RESULT_USED; + +/*! + @abstract Report whether the file name or URL denotes remote storage + @return 0 if local, 1 if remote. + @notes "Remote" means involving e.g. explicit network access, with the + implication that callers may wish to cache such files' contents locally. +*/ +int hisremote(const char *filename) HTS_RESULT_USED; + +/*! + @abstract Flush (for output streams) and close the stream + @return 0 if successful, or EOF (with errno set) if an error occurred. +*/ +int hclose(hFILE *fp) HTS_RESULT_USED; + +/*! + @abstract Close the stream, without flushing or propagating errors + @notes For use while cleaning up after an error only. Preserves errno. +*/ +void hclose_abruptly(hFILE *fp); + +/*! + @abstract Return the stream's error indicator + @return Non-zero (in fact, an errno value) if an error has occurred. + @notes This would be called herror() and return true/false to parallel + ferror(3), but a networking-related herror(3) function already exists. */ +static inline int herrno(hFILE *fp) +{ + return fp->has_errno; +} + +/*! + @abstract Clear the stream's error indicator +*/ +static inline void hclearerr(hFILE *fp) +{ + fp->has_errno = 0; +} + +/*! + @abstract Reposition the read/write stream offset + @return The resulting offset within the stream (as per lseek(2)), + or negative if an error occurred. +*/ +off_t hseek(hFILE *fp, off_t offset, int whence) HTS_RESULT_USED; + +/*! + @abstract Report the current stream offset + @return The offset within the stream, starting from zero. +*/ +static inline off_t htell(hFILE *fp) +{ + return fp->offset + (fp->begin - fp->buffer); +} + +/*! + @abstract Read one character from the stream + @return The character read, or EOF on end-of-file or error +*/ +static inline int hgetc(hFILE *fp) +{ + extern int hgetc2(hFILE *); + return (fp->end > fp->begin)? (unsigned char) *(fp->begin++) : hgetc2(fp); +} + +/*! + @abstract Peek at characters to be read without removing them from buffers + @param fp The file stream + @param buffer The buffer to which the peeked bytes will be written + @param nbytes The number of bytes to peek at; limited by the size of the + internal buffer, which could be as small as 4K. + @return The number of bytes peeked, which may be less than nbytes if EOF + is encountered; or negative, if there was an I/O error. + @notes The characters peeked at remain in the stream's internal buffer, + and will be returned by later hread() etc calls. +*/ +ssize_t hpeek(hFILE *fp, void *buffer, size_t nbytes) HTS_RESULT_USED; + +/*! + @abstract Read a block of characters from the file + @return The number of bytes read, or negative if an error occurred. + @notes The full nbytes requested will be returned, except as limited + by EOF or I/O errors. +*/ +static inline ssize_t HTS_RESULT_USED +hread(hFILE *fp, void *buffer, size_t nbytes) +{ + extern ssize_t hread2(hFILE *, void *, size_t, size_t); + + size_t n = fp->end - fp->begin; + if (n > nbytes) n = nbytes; + memcpy(buffer, fp->begin, n); + fp->begin += n; + return (n == nbytes)? (ssize_t) n : hread2(fp, buffer, nbytes, n); +} + +/*! + @abstract Write a character to the stream + @return The character written, or EOF if an error occurred. +*/ +static inline int hputc(int c, hFILE *fp) +{ + extern int hputc2(int, hFILE *); + if (fp->begin < fp->limit) *(fp->begin++) = c; + else c = hputc2(c, fp); + return c; +} + +/*! + @abstract Write a string to the stream + @return 0 if successful, or EOF if an error occurred. +*/ +static inline int hputs(const char *text, hFILE *fp) +{ + extern int hputs2(const char *, size_t, size_t, hFILE *); + + size_t nbytes = strlen(text), n = fp->limit - fp->begin; + if (n > nbytes) n = nbytes; + memcpy(fp->begin, text, n); + fp->begin += n; + return (n == nbytes)? 0 : hputs2(text, nbytes, n, fp); +} + +/*! + @abstract Write a block of characters to the file + @return Either nbytes, or negative if an error occurred. + @notes In the absence of I/O errors, the full nbytes will be written. +*/ +static inline ssize_t HTS_RESULT_USED +hwrite(hFILE *fp, const void *buffer, size_t nbytes) +{ + extern ssize_t hwrite2(hFILE *, const void *, size_t, size_t); + + size_t n = fp->limit - fp->begin; + if (n > nbytes) n = nbytes; + memcpy(fp->begin, buffer, n); + fp->begin += n; + return (n==nbytes)? (ssize_t) n : hwrite2(fp, buffer, nbytes, n); +} + +/*! + @abstract For writing streams, flush buffered output to the underlying stream + @return 0 if successful, or EOF if an error occurred. +*/ +int hflush(hFILE *fp) HTS_RESULT_USED; + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/hts.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,456 @@ +/* hts.h -- format-neutral I/O, indexing, and iterator API functions. + + Copyright (C) 2012-2014 Genome Research Ltd. + Copyright (C) 2012 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_HTS_H +#define HTSLIB_HTS_H + +#include <stddef.h> +#include <stdint.h> + +#ifndef HTS_BGZF_TYPEDEF +typedef struct BGZF BGZF; +#define HTS_BGZF_TYPEDEF +#endif +struct cram_fd; +struct hFILE; + +#ifndef KSTRING_T +#define KSTRING_T kstring_t +typedef struct __kstring_t { + size_t l, m; + char *s; +} kstring_t; +#endif + +#ifndef kroundup32 +#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x)) +#endif + +/** + * hts_expand() - expands memory block pointed to by $ptr; + * hts_expand0() the latter sets the newly allocated part to 0. + * + * @param n requested number of elements of type type_t + * @param m size of memory allocated + */ +#define hts_expand(type_t, n, m, ptr) if ((n) > (m)) { \ + (m) = (n); kroundup32(m); \ + (ptr) = (type_t*)realloc((ptr), (m) * sizeof(type_t)); \ + } +#define hts_expand0(type_t, n, m, ptr) if ((n) > (m)) { \ + int t = (m); (m) = (n); kroundup32(m); \ + (ptr) = (type_t*)realloc((ptr), (m) * sizeof(type_t)); \ + memset(((type_t*)ptr)+t,0,sizeof(type_t)*((m)-t)); \ + } + +/************ + * File I/O * + ************/ + +// Add new entries only at the end (but before the *_maximum entry) +// of these enums, as their numbering is part of the htslib ABI. + +enum htsFormatCategory { + unknown_category, + sequence_data, // Sequence data -- SAM, BAM, CRAM, etc + variant_data, // Variant calling data -- VCF, BCF, etc + index_file, // Index file associated with some data file + region_list, // Coordinate intervals or regions -- BED, etc + category_maximum = 32767 +}; + +enum htsExactFormat { + unknown_format, + binary_format, text_format, + sam, bam, bai, cram, crai, vcf, bcf, csi, gzi, tbi, bed, + format_maximum = 32767 +}; + +enum htsCompression { + no_compression, gzip, bgzf, custom, + compression_maximum = 32767 +}; + +typedef struct htsFormat { + enum htsFormatCategory category; + enum htsExactFormat format; + struct { short major, minor; } version; + enum htsCompression compression; + short compression_level; // currently unused + void *specific; // currently unused +} htsFormat; + +// Maintainers note htsFile cannot be an opaque structure because some of its +// fields are part of libhts.so's ABI (hence these fields must not be moved): +// - fp is used in the public sam_itr_next()/etc macros +// - is_bin is used directly in samtools <= 1.1 and bcftools <= 1.1 +// - is_write and is_cram are used directly in samtools <= 1.1 +// - fp is used directly in samtools (up to and including current develop) +// - line is used directly in bcftools (up to and including current develop) +typedef struct { + uint32_t is_bin:1, is_write:1, is_be:1, is_cram:1, dummy:28; + int64_t lineno; + kstring_t line; + char *fn, *fn_aux; + union { + BGZF *bgzf; + struct cram_fd *cram; + struct hFILE *hfile; + void *voidp; + } fp; + htsFormat format; +} htsFile; + +// REQUIRED_FIELDS +enum sam_fields { + SAM_QNAME = 0x00000001, + SAM_FLAG = 0x00000002, + SAM_RNAME = 0x00000004, + SAM_POS = 0x00000008, + SAM_MAPQ = 0x00000010, + SAM_CIGAR = 0x00000020, + SAM_RNEXT = 0x00000040, + SAM_PNEXT = 0x00000080, + SAM_TLEN = 0x00000100, + SAM_SEQ = 0x00000200, + SAM_QUAL = 0x00000400, + SAM_AUX = 0x00000800, + SAM_RGAUX = 0x00001000, +}; + +enum cram_option { + CRAM_OPT_DECODE_MD, + CRAM_OPT_PREFIX, + CRAM_OPT_VERBOSITY, + CRAM_OPT_SEQS_PER_SLICE, + CRAM_OPT_SLICES_PER_CONTAINER, + CRAM_OPT_RANGE, + CRAM_OPT_VERSION, + CRAM_OPT_EMBED_REF, + CRAM_OPT_IGNORE_MD5, + CRAM_OPT_REFERENCE, + CRAM_OPT_MULTI_SEQ_PER_SLICE, + CRAM_OPT_NO_REF, + CRAM_OPT_USE_BZIP2, + CRAM_OPT_SHARED_REF, + CRAM_OPT_NTHREADS, + CRAM_OPT_THREAD_POOL, + CRAM_OPT_USE_LZMA, + CRAM_OPT_USE_RANS, + CRAM_OPT_REQUIRED_FIELDS, +}; + +/********************** + * Exported functions * + **********************/ + +extern int hts_verbose; + +/*! @abstract Table for converting a nucleotide character to 4-bit encoding. +The input character may be either an IUPAC ambiguity code, '=' for 0, or +'0'/'1'/'2'/'3' for a result of 1/2/4/8. The result is encoded as 1/2/4/8 +for A/C/G/T or combinations of these bits for ambiguous bases. +*/ +extern const unsigned char seq_nt16_table[256]; + +/*! @abstract Table for converting a 4-bit encoded nucleotide to an IUPAC +ambiguity code letter (or '=' when given 0). +*/ +extern const char seq_nt16_str[]; + +/*! @abstract Table for converting a 4-bit encoded nucleotide to about 2 bits. +Returns 0/1/2/3 for 1/2/4/8 (i.e., A/C/G/T), or 4 otherwise (0 or ambiguous). +*/ +extern const int seq_nt16_int[]; + +#ifdef __cplusplus +extern "C" { +#endif + +/*! + @abstract Get the htslib version number + @return For released versions, a string like "N.N[.N]"; or git describe + output if using a library built within a Git repository. +*/ +const char *hts_version(void); + +/*! + @abstract Determine format by peeking at the start of a file + @param fp File opened for reading, positioned at the beginning + @param fmt Format structure that will be filled out on return + @return 0 for success, or negative if an error occurred. +*/ +int hts_detect_format(struct hFILE *fp, htsFormat *fmt); + +/*! + @abstract Get a human-readable description of the file format + @return Description string, to be freed by the caller after use. +*/ +char *hts_format_description(const htsFormat *format); + +/*! + @abstract Open a SAM/BAM/CRAM/VCF/BCF/etc file + @param fn The file name or "-" for stdin/stdout + @param mode Mode matching /[rwa][bcuz0-9]+/ + @discussion + With 'r' opens for reading; any further format mode letters are ignored + as the format is detected by checking the first few bytes or BGZF blocks + of the file. With 'w' or 'a' opens for writing or appending, with format + specifier letters: + b binary format (BAM, BCF, etc) rather than text (SAM, VCF, etc) + c CRAM format + g gzip compressed + u uncompressed + z bgzf compressed + [0-9] zlib compression level + Note that there is a distinction between 'u' and '0': the first yields + plain uncompressed output whereas the latter outputs uncompressed data + wrapped in the zlib format. + @example + [rw]b .. compressed BCF, BAM, FAI + [rw]u .. uncompressed BCF + [rw]z .. compressed VCF + [rw] .. uncompressed VCF +*/ +htsFile *hts_open(const char *fn, const char *mode); + +/*! + @abstract Open an existing stream as a SAM/BAM/CRAM/VCF/BCF/etc file + @param fn The already-open file handle + @param mode Open mode, as per hts_open() +*/ +htsFile *hts_hopen(struct hFILE *fp, const char *fn, const char *mode); + +/*! + @abstract Close a file handle, flushing buffered data for output streams + @param fp The file handle to be closed + @return 0 for success, or negative if an error occurred. +*/ +int hts_close(htsFile *fp); + +/*! + @abstract Returns the file's format information + @param fp The file handle + @return Read-only pointer to the file's htsFormat. +*/ +const htsFormat *hts_get_format(htsFile *fp); + +/*! + @abstract Sets a specified CRAM option on the open file handle. + @param fp The file handle open the open file. + @param opt The CRAM_OPT_* option. + @param ... Optional arguments, dependent on the option used. + @return 0 for success, or negative if an error occurred. +*/ +int hts_set_opt(htsFile *fp, enum cram_option opt, ...); + +int hts_getline(htsFile *fp, int delimiter, kstring_t *str); +char **hts_readlines(const char *fn, int *_n); +/*! + @abstract Parse comma-separated list or read list from a file + @param list File name or comma-separated list + @param is_file + @param _n Size of the output array (number of items read) + @return NULL on failure or pointer to newly allocated array of + strings +*/ +char **hts_readlist(const char *fn, int is_file, int *_n); + +/*! + @abstract Create extra threads to aid compress/decompression for this file + @param fp The file handle + @param n The number of worker threads to create + @return 0 for success, or negative if an error occurred. + @notes THIS THREADING API IS LIKELY TO CHANGE IN FUTURE. +*/ +int hts_set_threads(htsFile *fp, int n); + +/*! + @abstract Set .fai filename for a file opened for reading + @return 0 for success, negative on failure + @discussion + Called before *_hdr_read(), this provides the name of a .fai file + used to provide a reference list if the htsFile contains no @SQ headers. +*/ +int hts_set_fai_filename(htsFile *fp, const char *fn_aux); + +#ifdef __cplusplus +} +#endif + +/************ + * Indexing * + ************/ + +/*! +These HTS_IDX_* macros are used as special tid values for hts_itr_query()/etc, +producing iterators operating as follows: + - HTS_IDX_NOCOOR iterates over unmapped reads sorted at the end of the file + - HTS_IDX_START iterates over the entire file + - HTS_IDX_REST iterates from the current position to the end of the file + - HTS_IDX_NONE always returns "no more alignment records" +When one of these special tid values is used, beg and end are ignored. +When REST or NONE is used, idx is also ignored and may be NULL. +*/ +#define HTS_IDX_NOCOOR (-2) +#define HTS_IDX_START (-3) +#define HTS_IDX_REST (-4) +#define HTS_IDX_NONE (-5) + +#define HTS_FMT_CSI 0 +#define HTS_FMT_BAI 1 +#define HTS_FMT_TBI 2 +#define HTS_FMT_CRAI 3 + +struct __hts_idx_t; +typedef struct __hts_idx_t hts_idx_t; + +typedef struct { + uint64_t u, v; +} hts_pair64_t; + +typedef int hts_readrec_func(BGZF *fp, void *data, void *r, int *tid, int *beg, int *end); + +typedef struct { + uint32_t read_rest:1, finished:1, dummy:29; + int tid, beg, end, n_off, i; + int curr_tid, curr_beg, curr_end; + uint64_t curr_off; + hts_pair64_t *off; + hts_readrec_func *readrec; + struct { + int n, m; + int *a; + } bins; +} hts_itr_t; + +#ifdef __cplusplus +extern "C" { +#endif + + #define hts_bin_first(l) (((1<<(((l)<<1) + (l))) - 1) / 7) + #define hts_bin_parent(l) (((l) - 1) >> 3) + + hts_idx_t *hts_idx_init(int n, int fmt, uint64_t offset0, int min_shift, int n_lvls); + void hts_idx_destroy(hts_idx_t *idx); + int hts_idx_push(hts_idx_t *idx, int tid, int beg, int end, uint64_t offset, int is_mapped); + void hts_idx_finish(hts_idx_t *idx, uint64_t final_offset); + + void hts_idx_save(const hts_idx_t *idx, const char *fn, int fmt); + hts_idx_t *hts_idx_load(const char *fn, int fmt); + + uint8_t *hts_idx_get_meta(hts_idx_t *idx, int *l_meta); + void hts_idx_set_meta(hts_idx_t *idx, int l_meta, uint8_t *meta, int is_copy); + + int hts_idx_get_stat(const hts_idx_t* idx, int tid, uint64_t* mapped, uint64_t* unmapped); + uint64_t hts_idx_get_n_no_coor(const hts_idx_t* idx); + + const char *hts_parse_reg(const char *s, int *beg, int *end); + hts_itr_t *hts_itr_query(const hts_idx_t *idx, int tid, int beg, int end, hts_readrec_func *readrec); + void hts_itr_destroy(hts_itr_t *iter); + + typedef int (*hts_name2id_f)(void*, const char*); + typedef const char *(*hts_id2name_f)(void*, int); + typedef hts_itr_t *hts_itr_query_func(const hts_idx_t *idx, int tid, int beg, int end, hts_readrec_func *readrec); + + hts_itr_t *hts_itr_querys(const hts_idx_t *idx, const char *reg, hts_name2id_f getid, void *hdr, hts_itr_query_func *itr_query, hts_readrec_func *readrec); + int hts_itr_next(BGZF *fp, hts_itr_t *iter, void *r, void *data); + const char **hts_idx_seqnames(const hts_idx_t *idx, int *n, hts_id2name_f getid, void *hdr); // free only the array, not the values + + /** + * hts_file_type() - Convenience function to determine file type + * DEPRECATED: This function has been replaced by hts_detect_format(). + * It and these FT_* macros will be removed in a future HTSlib release. + */ + #define FT_UNKN 0 + #define FT_GZ 1 + #define FT_VCF 2 + #define FT_VCF_GZ (FT_GZ|FT_VCF) + #define FT_BCF (1<<2) + #define FT_BCF_GZ (FT_GZ|FT_BCF) + #define FT_STDIN (1<<3) + int hts_file_type(const char *fname); + + +#ifdef __cplusplus +} +#endif + +static inline int hts_reg2bin(int64_t beg, int64_t end, int min_shift, int n_lvls) +{ + int l, s = min_shift, t = ((1<<((n_lvls<<1) + n_lvls)) - 1) / 7; + for (--end, l = n_lvls; l > 0; --l, s += 3, t -= 1<<((l<<1)+l)) + if (beg>>s == end>>s) return t + (beg>>s); + return 0; +} + +static inline int hts_bin_bot(int bin, int n_lvls) +{ + int l, b; + for (l = 0, b = bin; b; ++l, b = hts_bin_parent(b)); // compute the level of bin + return (bin - hts_bin_first(l)) << (n_lvls - l) * 3; +} + +/************** + * Endianness * + **************/ + +static inline int ed_is_big(void) +{ + long one= 1; + return !(*((char *)(&one))); +} +static inline uint16_t ed_swap_2(uint16_t v) +{ + return (uint16_t)(((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8)); +} +static inline void *ed_swap_2p(void *x) +{ + *(uint16_t*)x = ed_swap_2(*(uint16_t*)x); + return x; +} +static inline uint32_t ed_swap_4(uint32_t v) +{ + v = ((v & 0x0000FFFFU) << 16) | (v >> 16); + return ((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8); +} +static inline void *ed_swap_4p(void *x) +{ + *(uint32_t*)x = ed_swap_4(*(uint32_t*)x); + return x; +} +static inline uint64_t ed_swap_8(uint64_t v) +{ + v = ((v & 0x00000000FFFFFFFFLLU) << 32) | (v >> 32); + v = ((v & 0x0000FFFF0000FFFFLLU) << 16) | ((v & 0xFFFF0000FFFF0000LLU) >> 16); + return ((v & 0x00FF00FF00FF00FFLLU) << 8) | ((v & 0xFF00FF00FF00FF00LLU) >> 8); +} +static inline void *ed_swap_8p(void *x) +{ + *(uint64_t*)x = ed_swap_8(*(uint64_t*)x); + return x; +} + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/hts_defs.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,47 @@ +/* hts_defs.h -- Miscellaneous definitions. + + Copyright (C) 2013-2014 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_HTS_DEFS_H +#define HTSLIB_HTS_DEFS_H + +#if __clang__major__ >= 2 || __GNUC__ >= 3 +#define HTS_NORETURN __attribute__ ((__noreturn__)) +#else +#define HTS_NORETURN +#endif + +#if (defined __clang__ && __clang_major__ >= 3) || \ + (defined __GNUC__ && (__GNUC__ > 4 || (__GNUC__==4 && __GNUC_MINOR__ >= 5))) +#define HTS_RESULT_USED __attribute__ ((__warn_unused_result__)) +#else +#define HTS_RESULT_USED +#endif + +#if defined __clang__ || defined __GNUC__ +#define HTS_UNUSED __attribute__ ((__unused__)) +#else +#define HTS_UNUSED +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/kfunc.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,75 @@ +/* The MIT License + + Copyright (C) 2010, 2013 Genome Research Ltd. + Copyright (C) 2011 Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +#ifndef HTSLIB_KFUNC_H +#define HTSLIB_KFUNC_H + +/* Log gamma function + * \log{\Gamma(z)} + * AS245, 2nd algorithm, http://lib.stat.cmu.edu/apstat/245 + */ +double kf_lgamma(double z); + +/* complementary error function + * \frac{2}{\sqrt{\pi}} \int_x^{\infty} e^{-t^2} dt + * AS66, 2nd algorithm, http://lib.stat.cmu.edu/apstat/66 + */ +double kf_erfc(double x); + +/* The following computes regularized incomplete gamma functions. + * Formulas are taken from Wiki, with additional input from Numerical + * Recipes in C (for modified Lentz's algorithm) and AS245 + * (http://lib.stat.cmu.edu/apstat/245). + * + * A good online calculator is available at: + * + * http://www.danielsoper.com/statcalc/calc23.aspx + * + * It calculates upper incomplete gamma function, which equals + * kf_gammaq(s,z)*tgamma(s). + */ + +double kf_gammap(double s, double z); +double kf_gammaq(double s, double z); + +/* Regularized incomplete beta function. The method is taken from + * Numerical Recipe in C, 2nd edition, section 6.4. The following web + * page calculates the incomplete beta function, which equals + * kf_betai(a,b,x) * gamma(a) * gamma(b) / gamma(a+b): + * + * http://www.danielsoper.com/statcalc/calc36.aspx + */ +double kf_betai(double a, double b, double x); + +/* + * n11 n12 | n1_ + * n21 n22 | n2_ + * -----------+---- + * n_1 n_2 | n + */ +double kt_fisher_exact(int n11, int n12, int n21, int n22, double *_left, double *_right, double *two); + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/khash.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,619 @@ +/* The MIT License + + Copyright (c) 2008, 2009, 2011 by Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +/* + An example: + +#include "khash.h" +KHASH_MAP_INIT_INT(32, char) +int main() { + int ret, is_missing; + khiter_t k; + khash_t(32) *h = kh_init(32); + k = kh_put(32, h, 5, &ret); + kh_value(h, k) = 10; + k = kh_get(32, h, 10); + is_missing = (k == kh_end(h)); + k = kh_get(32, h, 5); + kh_del(32, h, k); + for (k = kh_begin(h); k != kh_end(h); ++k) + if (kh_exist(h, k)) kh_value(h, k) = 1; + kh_destroy(32, h); + return 0; +} +*/ + +/* + 2013-05-02 (0.2.8): + + * Use quadratic probing. When the capacity is power of 2, stepping function + i*(i+1)/2 guarantees to traverse each bucket. It is better than double + hashing on cache performance and is more robust than linear probing. + + In theory, double hashing should be more robust than quadratic probing. + However, my implementation is probably not for large hash tables, because + the second hash function is closely tied to the first hash function, + which reduce the effectiveness of double hashing. + + Reference: http://research.cs.vt.edu/AVresearch/hashing/quadratic.php + + 2011-12-29 (0.2.7): + + * Minor code clean up; no actual effect. + + 2011-09-16 (0.2.6): + + * The capacity is a power of 2. This seems to dramatically improve the + speed for simple keys. Thank Zilong Tan for the suggestion. Reference: + + - http://code.google.com/p/ulib/ + - http://nothings.org/computer/judy/ + + * Allow to optionally use linear probing which usually has better + performance for random input. Double hashing is still the default as it + is more robust to certain non-random input. + + * Added Wang's integer hash function (not used by default). This hash + function is more robust to certain non-random input. + + 2011-02-14 (0.2.5): + + * Allow to declare global functions. + + 2009-09-26 (0.2.4): + + * Improve portability + + 2008-09-19 (0.2.3): + + * Corrected the example + * Improved interfaces + + 2008-09-11 (0.2.2): + + * Improved speed a little in kh_put() + + 2008-09-10 (0.2.1): + + * Added kh_clear() + * Fixed a compiling error + + 2008-09-02 (0.2.0): + + * Changed to token concatenation which increases flexibility. + + 2008-08-31 (0.1.2): + + * Fixed a bug in kh_get(), which has not been tested previously. + + 2008-08-31 (0.1.1): + + * Added destructor +*/ + + +#ifndef __AC_KHASH_H +#define __AC_KHASH_H + +/*! + @header + + Generic hash table library. + */ + +#define AC_VERSION_KHASH_H "0.2.8" + +#include <stdlib.h> +#include <string.h> +#include <limits.h> + +/* compiler specific configuration */ + +#if UINT_MAX == 0xffffffffu +typedef unsigned int khint32_t; +#elif ULONG_MAX == 0xffffffffu +typedef unsigned long khint32_t; +#endif + +#if ULONG_MAX == ULLONG_MAX +typedef unsigned long khint64_t; +#else +typedef unsigned long long khint64_t; +#endif + +#ifndef kh_inline +#ifdef _MSC_VER +#define kh_inline __inline +#else +#define kh_inline inline +#endif +#endif /* kh_inline */ + +typedef khint32_t khint_t; +typedef khint_t khiter_t; + +#define __ac_isempty(flag, i) ((flag[i>>4]>>((i&0xfU)<<1))&2) +#define __ac_isdel(flag, i) ((flag[i>>4]>>((i&0xfU)<<1))&1) +#define __ac_iseither(flag, i) ((flag[i>>4]>>((i&0xfU)<<1))&3) +#define __ac_set_isdel_false(flag, i) (flag[i>>4]&=~(1ul<<((i&0xfU)<<1))) +#define __ac_set_isempty_false(flag, i) (flag[i>>4]&=~(2ul<<((i&0xfU)<<1))) +#define __ac_set_isboth_false(flag, i) (flag[i>>4]&=~(3ul<<((i&0xfU)<<1))) +#define __ac_set_isdel_true(flag, i) (flag[i>>4]|=1ul<<((i&0xfU)<<1)) + +#define __ac_fsize(m) ((m) < 16? 1 : (m)>>4) + +#ifndef kroundup32 +#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x)) +#endif + +#ifndef kcalloc +#define kcalloc(N,Z) calloc(N,Z) +#endif +#ifndef kmalloc +#define kmalloc(Z) malloc(Z) +#endif +#ifndef krealloc +#define krealloc(P,Z) realloc(P,Z) +#endif +#ifndef kfree +#define kfree(P) free(P) +#endif + +static const double __ac_HASH_UPPER = 0.77; + +#define __KHASH_TYPE(name, khkey_t, khval_t) \ + typedef struct kh_##name##_s { \ + khint_t n_buckets, size, n_occupied, upper_bound; \ + khint32_t *flags; \ + khkey_t *keys; \ + khval_t *vals; \ + } kh_##name##_t; + +#define __KHASH_PROTOTYPES(name, khkey_t, khval_t) \ + extern kh_##name##_t *kh_init_##name(void); \ + extern void kh_destroy_##name(kh_##name##_t *h); \ + extern void kh_clear_##name(kh_##name##_t *h); \ + extern khint_t kh_get_##name(const kh_##name##_t *h, khkey_t key); \ + extern int kh_resize_##name(kh_##name##_t *h, khint_t new_n_buckets); \ + extern khint_t kh_put_##name(kh_##name##_t *h, khkey_t key, int *ret); \ + extern void kh_del_##name(kh_##name##_t *h, khint_t x); + +#define __KHASH_IMPL(name, SCOPE, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) \ + SCOPE kh_##name##_t *kh_init_##name(void) { \ + return (kh_##name##_t*)kcalloc(1, sizeof(kh_##name##_t)); \ + } \ + SCOPE void kh_destroy_##name(kh_##name##_t *h) \ + { \ + if (h) { \ + kfree((void *)h->keys); kfree(h->flags); \ + kfree((void *)h->vals); \ + kfree(h); \ + } \ + } \ + SCOPE void kh_clear_##name(kh_##name##_t *h) \ + { \ + if (h && h->flags) { \ + memset(h->flags, 0xaa, __ac_fsize(h->n_buckets) * sizeof(khint32_t)); \ + h->size = h->n_occupied = 0; \ + } \ + } \ + SCOPE khint_t kh_get_##name(const kh_##name##_t *h, khkey_t key) \ + { \ + if (h->n_buckets) { \ + khint_t k, i, last, mask, step = 0; \ + mask = h->n_buckets - 1; \ + k = __hash_func(key); i = k & mask; \ + last = i; \ + while (!__ac_isempty(h->flags, i) && (__ac_isdel(h->flags, i) || !__hash_equal(h->keys[i], key))) { \ + i = (i + (++step)) & mask; \ + if (i == last) return h->n_buckets; \ + } \ + return __ac_iseither(h->flags, i)? h->n_buckets : i; \ + } else return 0; \ + } \ + SCOPE int kh_resize_##name(kh_##name##_t *h, khint_t new_n_buckets) \ + { /* This function uses 0.25*n_buckets bytes of working space instead of [sizeof(key_t+val_t)+.25]*n_buckets. */ \ + khint32_t *new_flags = 0; \ + khint_t j = 1; \ + { \ + kroundup32(new_n_buckets); \ + if (new_n_buckets < 4) new_n_buckets = 4; \ + if (h->size >= (khint_t)(new_n_buckets * __ac_HASH_UPPER + 0.5)) j = 0; /* requested size is too small */ \ + else { /* hash table size to be changed (shrink or expand); rehash */ \ + new_flags = (khint32_t*)kmalloc(__ac_fsize(new_n_buckets) * sizeof(khint32_t)); \ + if (!new_flags) return -1; \ + memset(new_flags, 0xaa, __ac_fsize(new_n_buckets) * sizeof(khint32_t)); \ + if (h->n_buckets < new_n_buckets) { /* expand */ \ + khkey_t *new_keys = (khkey_t*)krealloc((void *)h->keys, new_n_buckets * sizeof(khkey_t)); \ + if (!new_keys) { kfree(new_flags); return -1; } \ + h->keys = new_keys; \ + if (kh_is_map) { \ + khval_t *new_vals = (khval_t*)krealloc((void *)h->vals, new_n_buckets * sizeof(khval_t)); \ + if (!new_vals) { kfree(new_flags); return -1; } \ + h->vals = new_vals; \ + } \ + } /* otherwise shrink */ \ + } \ + } \ + if (j) { /* rehashing is needed */ \ + for (j = 0; j != h->n_buckets; ++j) { \ + if (__ac_iseither(h->flags, j) == 0) { \ + khkey_t key = h->keys[j]; \ + khval_t val; \ + khint_t new_mask; \ + new_mask = new_n_buckets - 1; \ + if (kh_is_map) val = h->vals[j]; \ + __ac_set_isdel_true(h->flags, j); \ + while (1) { /* kick-out process; sort of like in Cuckoo hashing */ \ + khint_t k, i, step = 0; \ + k = __hash_func(key); \ + i = k & new_mask; \ + while (!__ac_isempty(new_flags, i)) i = (i + (++step)) & new_mask; \ + __ac_set_isempty_false(new_flags, i); \ + if (i < h->n_buckets && __ac_iseither(h->flags, i) == 0) { /* kick out the existing element */ \ + { khkey_t tmp = h->keys[i]; h->keys[i] = key; key = tmp; } \ + if (kh_is_map) { khval_t tmp = h->vals[i]; h->vals[i] = val; val = tmp; } \ + __ac_set_isdel_true(h->flags, i); /* mark it as deleted in the old hash table */ \ + } else { /* write the element and jump out of the loop */ \ + h->keys[i] = key; \ + if (kh_is_map) h->vals[i] = val; \ + break; \ + } \ + } \ + } \ + } \ + if (h->n_buckets > new_n_buckets) { /* shrink the hash table */ \ + h->keys = (khkey_t*)krealloc((void *)h->keys, new_n_buckets * sizeof(khkey_t)); \ + if (kh_is_map) h->vals = (khval_t*)krealloc((void *)h->vals, new_n_buckets * sizeof(khval_t)); \ + } \ + kfree(h->flags); /* free the working space */ \ + h->flags = new_flags; \ + h->n_buckets = new_n_buckets; \ + h->n_occupied = h->size; \ + h->upper_bound = (khint_t)(h->n_buckets * __ac_HASH_UPPER + 0.5); \ + } \ + return 0; \ + } \ + SCOPE khint_t kh_put_##name(kh_##name##_t *h, khkey_t key, int *ret) \ + { \ + khint_t x; \ + if (h->n_occupied >= h->upper_bound) { /* update the hash table */ \ + if (h->n_buckets > (h->size<<1)) { \ + if (kh_resize_##name(h, h->n_buckets - 1) < 0) { /* clear "deleted" elements */ \ + *ret = -1; return h->n_buckets; \ + } \ + } else if (kh_resize_##name(h, h->n_buckets + 1) < 0) { /* expand the hash table */ \ + *ret = -1; return h->n_buckets; \ + } \ + } /* TODO: to implement automatically shrinking; resize() already support shrinking */ \ + { \ + khint_t k, i, site, last, mask = h->n_buckets - 1, step = 0; \ + x = site = h->n_buckets; k = __hash_func(key); i = k & mask; \ + if (__ac_isempty(h->flags, i)) x = i; /* for speed up */ \ + else { \ + last = i; \ + while (!__ac_isempty(h->flags, i) && (__ac_isdel(h->flags, i) || !__hash_equal(h->keys[i], key))) { \ + if (__ac_isdel(h->flags, i)) site = i; \ + i = (i + (++step)) & mask; \ + if (i == last) { x = site; break; } \ + } \ + if (x == h->n_buckets) { \ + if (__ac_isempty(h->flags, i) && site != h->n_buckets) x = site; \ + else x = i; \ + } \ + } \ + } \ + if (__ac_isempty(h->flags, x)) { /* not present at all */ \ + h->keys[x] = key; \ + __ac_set_isboth_false(h->flags, x); \ + ++h->size; ++h->n_occupied; \ + *ret = 1; \ + } else if (__ac_isdel(h->flags, x)) { /* deleted */ \ + h->keys[x] = key; \ + __ac_set_isboth_false(h->flags, x); \ + ++h->size; \ + *ret = 2; \ + } else *ret = 0; /* Don't touch h->keys[x] if present and not deleted */ \ + return x; \ + } \ + SCOPE void kh_del_##name(kh_##name##_t *h, khint_t x) \ + { \ + if (x != h->n_buckets && !__ac_iseither(h->flags, x)) { \ + __ac_set_isdel_true(h->flags, x); \ + --h->size; \ + } \ + } + +#define KHASH_DECLARE(name, khkey_t, khval_t) \ + __KHASH_TYPE(name, khkey_t, khval_t) \ + __KHASH_PROTOTYPES(name, khkey_t, khval_t) + +#define KHASH_INIT2(name, SCOPE, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) \ + __KHASH_TYPE(name, khkey_t, khval_t) \ + __KHASH_IMPL(name, SCOPE, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) + +#define KHASH_INIT(name, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) \ + KHASH_INIT2(name, static kh_inline, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) + +/* --- BEGIN OF HASH FUNCTIONS --- */ + +/*! @function + @abstract Integer hash function + @param key The integer [khint32_t] + @return The hash value [khint_t] + */ +#define kh_int_hash_func(key) (khint32_t)(key) +/*! @function + @abstract Integer comparison function + */ +#define kh_int_hash_equal(a, b) ((a) == (b)) +/*! @function + @abstract 64-bit integer hash function + @param key The integer [khint64_t] + @return The hash value [khint_t] + */ +#define kh_int64_hash_func(key) (khint32_t)((key)>>33^(key)^(key)<<11) +/*! @function + @abstract 64-bit integer comparison function + */ +#define kh_int64_hash_equal(a, b) ((a) == (b)) +/*! @function + @abstract const char* hash function + @param s Pointer to a null terminated string + @return The hash value + */ +static kh_inline khint_t __ac_X31_hash_string(const char *s) +{ + khint_t h = (khint_t)*s; + if (h) for (++s ; *s; ++s) h = (h << 5) - h + (khint_t)*s; + return h; +} +/*! @function + @abstract Another interface to const char* hash function + @param key Pointer to a null terminated string [const char*] + @return The hash value [khint_t] + */ +#define kh_str_hash_func(key) __ac_X31_hash_string(key) +/*! @function + @abstract Const char* comparison function + */ +#define kh_str_hash_equal(a, b) (strcmp(a, b) == 0) + +static kh_inline khint_t __ac_Wang_hash(khint_t key) +{ + key += ~(key << 15); + key ^= (key >> 10); + key += (key << 3); + key ^= (key >> 6); + key += ~(key << 11); + key ^= (key >> 16); + return key; +} +#define kh_int_hash_func2(k) __ac_Wang_hash((khint_t)key) + +/* --- END OF HASH FUNCTIONS --- */ + +/* Other convenient macros... */ + +/*! + @abstract Type of the hash table. + @param name Name of the hash table [symbol] + */ +#define khash_t(name) kh_##name##_t + +/*! @function + @abstract Initiate a hash table. + @param name Name of the hash table [symbol] + @return Pointer to the hash table [khash_t(name)*] + */ +#define kh_init(name) kh_init_##name() + +/*! @function + @abstract Destroy a hash table. + @param name Name of the hash table [symbol] + @param h Pointer to the hash table [khash_t(name)*] + */ +#define kh_destroy(name, h) kh_destroy_##name(h) + +/*! @function + @abstract Reset a hash table without deallocating memory. + @param name Name of the hash table [symbol] + @param h Pointer to the hash table [khash_t(name)*] + */ +#define kh_clear(name, h) kh_clear_##name(h) + +/*! @function + @abstract Resize a hash table. + @param name Name of the hash table [symbol] + @param h Pointer to the hash table [khash_t(name)*] + @param s New size [khint_t] + */ +#define kh_resize(name, h, s) kh_resize_##name(h, s) + +/*! @function + @abstract Insert a key to the hash table. + @param name Name of the hash table [symbol] + @param h Pointer to the hash table [khash_t(name)*] + @param k Key [type of keys] + @param r Extra return code: -1 if the operation failed; + 0 if the key is present in the hash table; + 1 if the bucket is empty (never used); 2 if the element in + the bucket has been deleted [int*] + @return Iterator to the inserted element [khint_t] + */ +#define kh_put(name, h, k, r) kh_put_##name(h, k, r) + +/*! @function + @abstract Retrieve a key from the hash table. + @param name Name of the hash table [symbol] + @param h Pointer to the hash table [khash_t(name)*] + @param k Key [type of keys] + @return Iterator to the found element, or kh_end(h) if the element is absent [khint_t] + */ +#define kh_get(name, h, k) kh_get_##name(h, k) + +/*! @function + @abstract Remove a key from the hash table. + @param name Name of the hash table [symbol] + @param h Pointer to the hash table [khash_t(name)*] + @param k Iterator to the element to be deleted [khint_t] + */ +#define kh_del(name, h, k) kh_del_##name(h, k) + +/*! @function + @abstract Test whether a bucket contains data. + @param h Pointer to the hash table [khash_t(name)*] + @param x Iterator to the bucket [khint_t] + @return 1 if containing data; 0 otherwise [int] + */ +#define kh_exist(h, x) (!__ac_iseither((h)->flags, (x))) + +/*! @function + @abstract Get key given an iterator + @param h Pointer to the hash table [khash_t(name)*] + @param x Iterator to the bucket [khint_t] + @return Key [type of keys] + */ +#define kh_key(h, x) ((h)->keys[x]) + +/*! @function + @abstract Get value given an iterator + @param h Pointer to the hash table [khash_t(name)*] + @param x Iterator to the bucket [khint_t] + @return Value [type of values] + @discussion For hash sets, calling this results in segfault. + */ +#define kh_val(h, x) ((h)->vals[x]) + +/*! @function + @abstract Alias of kh_val() + */ +#define kh_value(h, x) ((h)->vals[x]) + +/*! @function + @abstract Get the start iterator + @param h Pointer to the hash table [khash_t(name)*] + @return The start iterator [khint_t] + */ +#define kh_begin(h) (khint_t)(0) + +/*! @function + @abstract Get the end iterator + @param h Pointer to the hash table [khash_t(name)*] + @return The end iterator [khint_t] + */ +#define kh_end(h) ((h)->n_buckets) + +/*! @function + @abstract Get the number of elements in the hash table + @param h Pointer to the hash table [khash_t(name)*] + @return Number of elements in the hash table [khint_t] + */ +#define kh_size(h) ((h)->size) + +/*! @function + @abstract Get the number of buckets in the hash table + @param h Pointer to the hash table [khash_t(name)*] + @return Number of buckets in the hash table [khint_t] + */ +#define kh_n_buckets(h) ((h)->n_buckets) + +/*! @function + @abstract Iterate over the entries in the hash table + @param h Pointer to the hash table [khash_t(name)*] + @param kvar Variable to which key will be assigned + @param vvar Variable to which value will be assigned + @param code Block of code to execute + */ +#define kh_foreach(h, kvar, vvar, code) { khint_t __i; \ + for (__i = kh_begin(h); __i != kh_end(h); ++__i) { \ + if (!kh_exist(h,__i)) continue; \ + (kvar) = kh_key(h,__i); \ + (vvar) = kh_val(h,__i); \ + code; \ + } } + +/*! @function + @abstract Iterate over the values in the hash table + @param h Pointer to the hash table [khash_t(name)*] + @param vvar Variable to which value will be assigned + @param code Block of code to execute + */ +#define kh_foreach_value(h, vvar, code) { khint_t __i; \ + for (__i = kh_begin(h); __i != kh_end(h); ++__i) { \ + if (!kh_exist(h,__i)) continue; \ + (vvar) = kh_val(h,__i); \ + code; \ + } } + +/* More conenient interfaces */ + +/*! @function + @abstract Instantiate a hash set containing integer keys + @param name Name of the hash table [symbol] + */ +#define KHASH_SET_INIT_INT(name) \ + KHASH_INIT(name, khint32_t, char, 0, kh_int_hash_func, kh_int_hash_equal) + +/*! @function + @abstract Instantiate a hash map containing integer keys + @param name Name of the hash table [symbol] + @param khval_t Type of values [type] + */ +#define KHASH_MAP_INIT_INT(name, khval_t) \ + KHASH_INIT(name, khint32_t, khval_t, 1, kh_int_hash_func, kh_int_hash_equal) + +/*! @function + @abstract Instantiate a hash map containing 64-bit integer keys + @param name Name of the hash table [symbol] + */ +#define KHASH_SET_INIT_INT64(name) \ + KHASH_INIT(name, khint64_t, char, 0, kh_int64_hash_func, kh_int64_hash_equal) + +/*! @function + @abstract Instantiate a hash map containing 64-bit integer keys + @param name Name of the hash table [symbol] + @param khval_t Type of values [type] + */ +#define KHASH_MAP_INIT_INT64(name, khval_t) \ + KHASH_INIT(name, khint64_t, khval_t, 1, kh_int64_hash_func, kh_int64_hash_equal) + +typedef const char *kh_cstr_t; +/*! @function + @abstract Instantiate a hash map containing const char* keys + @param name Name of the hash table [symbol] + */ +#define KHASH_SET_INIT_STR(name) \ + KHASH_INIT(name, kh_cstr_t, char, 0, kh_str_hash_func, kh_str_hash_equal) + +/*! @function + @abstract Instantiate a hash map containing const char* keys + @param name Name of the hash table [symbol] + @param khval_t Type of values [type] + */ +#define KHASH_MAP_INIT_STR(name, khval_t) \ + KHASH_INIT(name, kh_cstr_t, khval_t, 1, kh_str_hash_func, kh_str_hash_equal) + +#endif /* __AC_KHASH_H */
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/khash_str2int.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,133 @@ +/* khash_str2int.h -- C-string to integer hash table. + + Copyright (C) 2013 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_KHASH_STR2INT_H +#define HTSLIB_KHASH_STR2INT_H + +#include <htslib/khash.h> + +KHASH_MAP_INIT_STR(str2int, int) + +/* + * Wrappers for khash dictionaries used by mpileup. + */ + +static inline void *khash_str2int_init(void) +{ + return kh_init(str2int); +} + +/* + * Destroy the hash structure, but not the keys + */ +static inline void khash_str2int_destroy(void *_hash) +{ + khash_t(str2int) *hash = (khash_t(str2int)*)_hash; + if (hash) kh_destroy(str2int, hash); // Note that strings are not freed. +} + +/* + * Destroys both the hash structure and the keys + */ +static inline void khash_str2int_destroy_free(void *_hash) +{ + khash_t(str2int) *hash = (khash_t(str2int)*)_hash; + khint_t k; + if (hash == 0) return; + for (k = 0; k < kh_end(hash); ++k) + if (kh_exist(hash, k)) free((char*)kh_key(hash, k)); + kh_destroy(str2int, hash); +} + +/* + * Returns 1 if key exists or 0 if not + */ +static inline int khash_str2int_has_key(void *_hash, const char *str) +{ + khash_t(str2int) *hash = (khash_t(str2int)*)_hash; + khint_t k = kh_get(str2int, hash, str); + if ( k == kh_end(hash) ) return 0; + return 1; +} + +/* + * Returns 0 on success and -1 when the key is not present. On success, + * *value is set, unless NULL is passed. + */ +static inline int khash_str2int_get(void *_hash, const char *str, int *value) +{ + khash_t(str2int) *hash = (khash_t(str2int)*)_hash; + khint_t k; + if ( !hash ) return -1; + k = kh_get(str2int, hash, str); + if ( k == kh_end(hash) ) return -1; + if ( !value ) return 0; + *value = kh_val(hash, k); + return 0; +} + +/* + * Add a new string to the dictionary, auto-incrementing the value. + * On success returns the newly inserted integer id, on error -1 + * is returned. Note that the key must continue to exist throughout + * the whole life of _hash. + */ +static inline int khash_str2int_inc(void *_hash, const char *str) +{ + khint_t k; + int ret; + khash_t(str2int) *hash = (khash_t(str2int)*)_hash; + if ( !hash ) return -1; + k = kh_put(str2int, hash, str, &ret); + if (ret == 0) return kh_val(hash, k); + kh_val(hash, k) = kh_size(hash) - 1; + return kh_val(hash, k); +} + +/* + * Set a new key,value pair. On success returns the bin index, on + * error -1 is returned. Note that the key must contnue to exist + * throughout the whole life of _hash. + */ +static inline int khash_str2int_set(void *_hash, const char *str, int value) +{ + khint_t k; + int ret; + khash_t(str2int) *hash = (khash_t(str2int)*)_hash; + if ( !hash ) return -1; + k = kh_put(str2int, hash, str, &ret); + kh_val(hash,k) = value; + return k; +} + +/* + * Return the number of keys in the hash table. + */ +static inline int khash_str2int_size(void *_hash) +{ + khash_t(str2int) *hash = (khash_t(str2int)*)_hash; + return kh_size(hash); +} + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/klist.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,121 @@ +/* The MIT License + + Copyright (c) 2008-2009, by Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +#ifndef _AC_KLIST_H +#define _AC_KLIST_H + +#include <stdlib.h> + +#define KMEMPOOL_INIT(name, kmptype_t, kmpfree_f) \ + typedef struct { \ + size_t cnt, n, max; \ + kmptype_t **buf; \ + } kmp_##name##_t; \ + static inline kmp_##name##_t *kmp_init_##name(void) { \ + return calloc(1, sizeof(kmp_##name##_t)); \ + } \ + static inline void kmp_destroy_##name(kmp_##name##_t *mp) { \ + size_t k; \ + for (k = 0; k < mp->n; ++k) { \ + kmpfree_f(mp->buf[k]); free(mp->buf[k]); \ + } \ + free(mp->buf); free(mp); \ + } \ + static inline kmptype_t *kmp_alloc_##name(kmp_##name##_t *mp) { \ + ++mp->cnt; \ + if (mp->n == 0) return calloc(1, sizeof(kmptype_t)); \ + return mp->buf[--mp->n]; \ + } \ + static inline void kmp_free_##name(kmp_##name##_t *mp, kmptype_t *p) { \ + --mp->cnt; \ + if (mp->n == mp->max) { \ + mp->max = mp->max? mp->max<<1 : 16; \ + mp->buf = realloc(mp->buf, sizeof(kmptype_t *) * mp->max); \ + } \ + mp->buf[mp->n++] = p; \ + } + +#define kmempool_t(name) kmp_##name##_t +#define kmp_init(name) kmp_init_##name() +#define kmp_destroy(name, mp) kmp_destroy_##name(mp) +#define kmp_alloc(name, mp) kmp_alloc_##name(mp) +#define kmp_free(name, mp, p) kmp_free_##name(mp, p) + +#define KLIST_INIT(name, kltype_t, kmpfree_t) \ + struct __kl1_##name { \ + kltype_t data; \ + struct __kl1_##name *next; \ + }; \ + typedef struct __kl1_##name kl1_##name; \ + KMEMPOOL_INIT(name, kl1_##name, kmpfree_t) \ + typedef struct { \ + kl1_##name *head, *tail; \ + kmp_##name##_t *mp; \ + size_t size; \ + } kl_##name##_t; \ + static inline kl_##name##_t *kl_init_##name(void) { \ + kl_##name##_t *kl = calloc(1, sizeof(kl_##name##_t)); \ + kl->mp = kmp_init(name); \ + kl->head = kl->tail = kmp_alloc(name, kl->mp); \ + kl->head->next = 0; \ + return kl; \ + } \ + static inline void kl_destroy_##name(kl_##name##_t *kl) { \ + kl1_##name *p; \ + for (p = kl->head; p != kl->tail; p = p->next) \ + kmp_free(name, kl->mp, p); \ + kmp_free(name, kl->mp, p); \ + kmp_destroy(name, kl->mp); \ + free(kl); \ + } \ + static inline kltype_t *kl_pushp_##name(kl_##name##_t *kl) { \ + kl1_##name *q, *p = kmp_alloc(name, kl->mp); \ + q = kl->tail; p->next = 0; kl->tail->next = p; kl->tail = p; \ + ++kl->size; \ + return &q->data; \ + } \ + static inline int kl_shift_##name(kl_##name##_t *kl, kltype_t *d) { \ + kl1_##name *p; \ + if (kl->head->next == 0) return -1; \ + --kl->size; \ + p = kl->head; kl->head = kl->head->next; \ + if (d) *d = p->data; \ + kmp_free(name, kl->mp, p); \ + return 0; \ + } + +#define kliter_t(name) kl1_##name +#define klist_t(name) kl_##name##_t +#define kl_val(iter) ((iter)->data) +#define kl_next(iter) ((iter)->next) +#define kl_begin(kl) ((kl)->head) +#define kl_end(kl) ((kl)->tail) + +#define kl_init(name) kl_init_##name() +#define kl_destroy(name, kl) kl_destroy_##name(kl) +#define kl_pushp(name, kl) kl_pushp_##name(kl) +#define kl_shift(name, kl, d) kl_shift_##name(kl, d) + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/knetfile.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,101 @@ +/* The MIT License + + Copyright (c) 2008 by Genome Research Ltd (GRL). + 2010 by Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +#ifndef KNETFILE_H +#define KNETFILE_H + +#include <stdint.h> +#include <fcntl.h> + +#ifndef _WIN32 +#define netread(fd, ptr, len) read(fd, ptr, len) +#define netwrite(fd, ptr, len) write(fd, ptr, len) +#define netclose(fd) close(fd) +#else +#include <winsock2.h> +#define netread(fd, ptr, len) recv(fd, ptr, len, 0) +#define netwrite(fd, ptr, len) send(fd, ptr, len, 0) +#define netclose(fd) closesocket(fd) +#endif + +// FIXME: currently I/O is unbuffered + +#define KNF_TYPE_LOCAL 1 +#define KNF_TYPE_FTP 2 +#define KNF_TYPE_HTTP 3 + +typedef struct knetFile_s { + int type, fd; + int64_t offset; + char *host, *port; + + // the following are for FTP only + int ctrl_fd, pasv_ip[4], pasv_port, max_response, no_reconnect, is_ready; + char *response, *retr, *size_cmd; + int64_t seek_offset; // for lazy seek + int64_t file_size; + + // the following are for HTTP only + char *path, *http_host; +} knetFile; + +#define knet_tell(fp) ((fp)->offset) +#define knet_fileno(fp) ((fp)->fd) + +#ifdef __cplusplus +extern "C" { +#endif + +#ifdef _WIN32 + int knet_win32_init(); + void knet_win32_destroy(); +#endif + + knetFile *knet_open(const char *fn, const char *mode); + + /* + This only works with local files. + */ + knetFile *knet_dopen(int fd, const char *mode); + + /* + If ->is_ready==0, this routine updates ->fd; otherwise, it simply + reads from ->fd. + */ + ssize_t knet_read(knetFile *fp, void *buf, size_t len); + + /* + This routine only sets ->offset and ->is_ready=0. It does not + communicate with the FTP server. + */ + off_t knet_seek(knetFile *fp, off_t off, int whence); + int knet_close(knetFile *fp); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/kseq.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,253 @@ +/* The MIT License + + Copyright (c) 2008, 2009, 2011 Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +/* Last Modified: 05MAR2012 */ + +#ifndef AC_KSEQ_H +#define AC_KSEQ_H + +#include <ctype.h> +#include <string.h> +#include <stdlib.h> + +#define KS_SEP_SPACE 0 // isspace(): \t, \n, \v, \f, \r +#define KS_SEP_TAB 1 // isspace() && !' ' +#define KS_SEP_LINE 2 // line separator: "\n" (Unix) or "\r\n" (Windows) +#define KS_SEP_MAX 2 + +#define __KS_TYPE(type_t) \ + typedef struct __kstream_t { \ + int begin, end; \ + int is_eof:2, bufsize:30; \ + uint64_t seek_pos; \ + type_t f; \ + unsigned char *buf; \ + } kstream_t; + +#define ks_eof(ks) ((ks)->is_eof && (ks)->begin >= (ks)->end) +#define ks_rewind(ks) ((ks)->is_eof = (ks)->begin = (ks)->end = 0) + +#define __KS_BASIC(SCOPE, type_t, __bufsize) \ + SCOPE kstream_t *ks_init(type_t f) \ + { \ + kstream_t *ks = (kstream_t*)calloc(1, sizeof(kstream_t)); \ + ks->f = f; ks->bufsize = __bufsize; \ + ks->buf = (unsigned char*)malloc(__bufsize); \ + return ks; \ + } \ + SCOPE void ks_destroy(kstream_t *ks) \ + { \ + if (!ks) return; \ + free(ks->buf); \ + free(ks); \ + } + +#define __KS_INLINED(__read) \ + static inline int ks_getc(kstream_t *ks) \ + { \ + if (ks->is_eof && ks->begin >= ks->end) return -1; \ + if (ks->begin >= ks->end) { \ + ks->begin = 0; \ + ks->end = __read(ks->f, ks->buf, ks->bufsize); \ + if (ks->end == 0) { ks->is_eof = 1; return -1; } \ + } \ + ks->seek_pos++; \ + return (int)ks->buf[ks->begin++]; \ + } \ + static inline int ks_getuntil(kstream_t *ks, int delimiter, kstring_t *str, int *dret) \ + { return ks_getuntil2(ks, delimiter, str, dret, 0); } + +#ifndef KSTRING_T +#define KSTRING_T kstring_t +typedef struct __kstring_t { + size_t l, m; + char *s; +} kstring_t; +#endif + +#ifndef kroundup32 +#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x)) +#endif + +#define __KS_GETUNTIL(SCOPE, __read) \ + SCOPE int ks_getuntil2(kstream_t *ks, int delimiter, kstring_t *str, int *dret, int append) \ + { \ + int gotany = 0; \ + if (dret) *dret = 0; \ + str->l = append? str->l : 0; \ + uint64_t seek_pos = str->l; \ + for (;;) { \ + int i; \ + if (ks->begin >= ks->end) { \ + if (!ks->is_eof) { \ + ks->begin = 0; \ + ks->end = __read(ks->f, ks->buf, ks->bufsize); \ + if (ks->end == 0) { ks->is_eof = 1; break; } \ + } else break; \ + } \ + if (delimiter == KS_SEP_LINE) { \ + for (i = ks->begin; i < ks->end; ++i) \ + if (ks->buf[i] == '\n') break; \ + } else if (delimiter > KS_SEP_MAX) { \ + for (i = ks->begin; i < ks->end; ++i) \ + if (ks->buf[i] == delimiter) break; \ + } else if (delimiter == KS_SEP_SPACE) { \ + for (i = ks->begin; i < ks->end; ++i) \ + if (isspace(ks->buf[i])) break; \ + } else if (delimiter == KS_SEP_TAB) { \ + for (i = ks->begin; i < ks->end; ++i) \ + if (isspace(ks->buf[i]) && ks->buf[i] != ' ') break; \ + } else i = 0; /* never come to here! */ \ + if (str->m - str->l < (size_t)(i - ks->begin + 1)) { \ + str->m = str->l + (i - ks->begin) + 1; \ + kroundup32(str->m); \ + str->s = (char*)realloc(str->s, str->m); \ + } \ + seek_pos += i - ks->begin; if ( i < ks->end ) seek_pos++; \ + gotany = 1; \ + memcpy(str->s + str->l, ks->buf + ks->begin, i - ks->begin); \ + str->l = str->l + (i - ks->begin); \ + ks->begin = i + 1; \ + if (i < ks->end) { \ + if (dret) *dret = ks->buf[i]; \ + break; \ + } \ + } \ + if (!gotany && ks_eof(ks)) return -1; \ + ks->seek_pos += seek_pos; \ + if (str->s == 0) { \ + str->m = 1; \ + str->s = (char*)calloc(1, 1); \ + } else if (delimiter == KS_SEP_LINE && str->l > 1 && str->s[str->l-1] == '\r') --str->l; \ + str->s[str->l] = '\0'; \ + return str->l; \ + } + +#define KSTREAM_INIT2(SCOPE, type_t, __read, __bufsize) \ + __KS_TYPE(type_t) \ + __KS_BASIC(SCOPE, type_t, __bufsize) \ + __KS_GETUNTIL(SCOPE, __read) \ + __KS_INLINED(__read) + +#define KSTREAM_INIT(type_t, __read, __bufsize) KSTREAM_INIT2(static, type_t, __read, __bufsize) + +#define KSTREAM_DECLARE(type_t, __read) \ + __KS_TYPE(type_t) \ + extern int ks_getuntil2(kstream_t *ks, int delimiter, kstring_t *str, int *dret, int append); \ + extern kstream_t *ks_init(type_t f); \ + extern void ks_destroy(kstream_t *ks); \ + __KS_INLINED(__read) + +/****************** + * FASTA/Q parser * + ******************/ + +#define kseq_rewind(ks) ((ks)->last_char = (ks)->f->is_eof = (ks)->f->begin = (ks)->f->end = 0) + +#define __KSEQ_BASIC(SCOPE, type_t) \ + SCOPE kseq_t *kseq_init(type_t fd) \ + { \ + kseq_t *s = (kseq_t*)calloc(1, sizeof(kseq_t)); \ + s->f = ks_init(fd); \ + return s; \ + } \ + SCOPE void kseq_destroy(kseq_t *ks) \ + { \ + if (!ks) return; \ + free(ks->name.s); free(ks->comment.s); free(ks->seq.s); free(ks->qual.s); \ + ks_destroy(ks->f); \ + free(ks); \ + } + +/* Return value: + >=0 length of the sequence (normal) + -1 end-of-file + -2 truncated quality string + */ +#define __KSEQ_READ(SCOPE) \ + SCOPE int kseq_read(kseq_t *seq) \ + { \ + int c; \ + kstream_t *ks = seq->f; \ + if (seq->last_char == 0) { /* then jump to the next header line */ \ + while ((c = ks_getc(ks)) != -1 && c != '>' && c != '@'); \ + if (c == -1) return -1; /* end of file */ \ + seq->last_char = c; \ + } /* else: the first header char has been read in the previous call */ \ + seq->comment.l = seq->seq.l = seq->qual.l = 0; /* reset all members */ \ + if (ks_getuntil(ks, 0, &seq->name, &c) < 0) return -1; /* normal exit: EOF */ \ + if (c != '\n') ks_getuntil(ks, KS_SEP_LINE, &seq->comment, 0); /* read FASTA/Q comment */ \ + if (seq->seq.s == 0) { /* we can do this in the loop below, but that is slower */ \ + seq->seq.m = 256; \ + seq->seq.s = (char*)malloc(seq->seq.m); \ + } \ + while ((c = ks_getc(ks)) != -1 && c != '>' && c != '+' && c != '@') { \ + if (c == '\n') continue; /* skip empty lines */ \ + seq->seq.s[seq->seq.l++] = c; /* this is safe: we always have enough space for 1 char */ \ + ks_getuntil2(ks, KS_SEP_LINE, &seq->seq, 0, 1); /* read the rest of the line */ \ + } \ + if (c == '>' || c == '@') seq->last_char = c; /* the first header char has been read */ \ + if (seq->seq.l + 1 >= seq->seq.m) { /* seq->seq.s[seq->seq.l] below may be out of boundary */ \ + seq->seq.m = seq->seq.l + 2; \ + kroundup32(seq->seq.m); /* rounded to the next closest 2^k */ \ + seq->seq.s = (char*)realloc(seq->seq.s, seq->seq.m); \ + } \ + seq->seq.s[seq->seq.l] = 0; /* null terminated string */ \ + if (c != '+') return seq->seq.l; /* FASTA */ \ + if (seq->qual.m < seq->seq.m) { /* allocate memory for qual in case insufficient */ \ + seq->qual.m = seq->seq.m; \ + seq->qual.s = (char*)realloc(seq->qual.s, seq->qual.m); \ + } \ + while ((c = ks_getc(ks)) != -1 && c != '\n'); /* skip the rest of '+' line */ \ + if (c == -1) return -2; /* error: no quality string */ \ + while (ks_getuntil2(ks, KS_SEP_LINE, &seq->qual, 0, 1) >= 0 && seq->qual.l < seq->seq.l); \ + seq->last_char = 0; /* we have not come to the next header line */ \ + if (seq->seq.l != seq->qual.l) return -2; /* error: qual string is of a different length */ \ + return seq->seq.l; \ + } + +#define __KSEQ_TYPE(type_t) \ + typedef struct { \ + kstring_t name, comment, seq, qual; \ + int last_char; \ + kstream_t *f; \ + } kseq_t; + +#define KSEQ_INIT2(SCOPE, type_t, __read) \ + KSTREAM_INIT(type_t, __read, 16384) \ + __KSEQ_TYPE(type_t) \ + __KSEQ_BASIC(SCOPE, type_t) \ + __KSEQ_READ(SCOPE) + +#define KSEQ_INIT(type_t, __read) KSEQ_INIT2(static, type_t, __read) + +#define KSEQ_DECLARE(type_t) \ + __KS_TYPE(type_t) \ + __KSEQ_TYPE(type_t) \ + extern kseq_t *kseq_init(type_t fd); \ + void kseq_destroy(kseq_t *ks); \ + int kseq_read(kseq_t *seq); + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/ksort.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,285 @@ +/* The MIT License + + Copyright (c) 2008 Genome Research Ltd (GRL). + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +/* Contact: Heng Li <lh3@sanger.ac.uk> */ + +/* + 2012-12-11 (0.1.4): + + * Defined __ks_insertsort_##name as static to compile with C99. + + 2008-11-16 (0.1.4): + + * Fixed a bug in introsort() that happens in rare cases. + + 2008-11-05 (0.1.3): + + * Fixed a bug in introsort() for complex comparisons. + + * Fixed a bug in mergesort(). The previous version is not stable. + + 2008-09-15 (0.1.2): + + * Accelerated introsort. On my Mac (not on another Linux machine), + my implementation is as fast as std::sort on random input. + + * Added combsort and in introsort, switch to combsort if the + recursion is too deep. + + 2008-09-13 (0.1.1): + + * Added k-small algorithm + + 2008-09-05 (0.1.0): + + * Initial version + +*/ + +#ifndef AC_KSORT_H +#define AC_KSORT_H + +#include <stdlib.h> +#include <string.h> + +typedef struct { + void *left, *right; + int depth; +} ks_isort_stack_t; + +#define KSORT_SWAP(type_t, a, b) { register type_t t=(a); (a)=(b); (b)=t; } + +#define KSORT_INIT(name, type_t, __sort_lt) \ + void ks_mergesort_##name(size_t n, type_t array[], type_t temp[]) \ + { \ + type_t *a2[2], *a, *b; \ + int curr, shift; \ + \ + a2[0] = array; \ + a2[1] = temp? temp : (type_t*)malloc(sizeof(type_t) * n); \ + for (curr = 0, shift = 0; (1ul<<shift) < n; ++shift) { \ + a = a2[curr]; b = a2[1-curr]; \ + if (shift == 0) { \ + type_t *p = b, *i, *eb = a + n; \ + for (i = a; i < eb; i += 2) { \ + if (i == eb - 1) *p++ = *i; \ + else { \ + if (__sort_lt(*(i+1), *i)) { \ + *p++ = *(i+1); *p++ = *i; \ + } else { \ + *p++ = *i; *p++ = *(i+1); \ + } \ + } \ + } \ + } else { \ + size_t i, step = 1ul<<shift; \ + for (i = 0; i < n; i += step<<1) { \ + type_t *p, *j, *k, *ea, *eb; \ + if (n < i + step) { \ + ea = a + n; eb = a; \ + } else { \ + ea = a + i + step; \ + eb = a + (n < i + (step<<1)? n : i + (step<<1)); \ + } \ + j = a + i; k = a + i + step; p = b + i; \ + while (j < ea && k < eb) { \ + if (__sort_lt(*k, *j)) *p++ = *k++; \ + else *p++ = *j++; \ + } \ + while (j < ea) *p++ = *j++; \ + while (k < eb) *p++ = *k++; \ + } \ + } \ + curr = 1 - curr; \ + } \ + if (curr == 1) { \ + type_t *p = a2[0], *i = a2[1], *eb = array + n; \ + for (; p < eb; ++i) *p++ = *i; \ + } \ + if (temp == 0) free(a2[1]); \ + } \ + void ks_heapadjust_##name(size_t i, size_t n, type_t l[]) \ + { \ + size_t k = i; \ + type_t tmp = l[i]; \ + while ((k = (k << 1) + 1) < n) { \ + if (k != n - 1 && __sort_lt(l[k], l[k+1])) ++k; \ + if (__sort_lt(l[k], tmp)) break; \ + l[i] = l[k]; i = k; \ + } \ + l[i] = tmp; \ + } \ + void ks_heapmake_##name(size_t lsize, type_t l[]) \ + { \ + size_t i; \ + for (i = (lsize >> 1) - 1; i != (size_t)(-1); --i) \ + ks_heapadjust_##name(i, lsize, l); \ + } \ + void ks_heapsort_##name(size_t lsize, type_t l[]) \ + { \ + size_t i; \ + for (i = lsize - 1; i > 0; --i) { \ + type_t tmp; \ + tmp = *l; *l = l[i]; l[i] = tmp; ks_heapadjust_##name(0, i, l); \ + } \ + } \ + static inline void __ks_insertsort_##name(type_t *s, type_t *t) \ + { \ + type_t *i, *j, swap_tmp; \ + for (i = s + 1; i < t; ++i) \ + for (j = i; j > s && __sort_lt(*j, *(j-1)); --j) { \ + swap_tmp = *j; *j = *(j-1); *(j-1) = swap_tmp; \ + } \ + } \ + void ks_combsort_##name(size_t n, type_t a[]) \ + { \ + const double shrink_factor = 1.2473309501039786540366528676643; \ + int do_swap; \ + size_t gap = n; \ + type_t tmp, *i, *j; \ + do { \ + if (gap > 2) { \ + gap = (size_t)(gap / shrink_factor); \ + if (gap == 9 || gap == 10) gap = 11; \ + } \ + do_swap = 0; \ + for (i = a; i < a + n - gap; ++i) { \ + j = i + gap; \ + if (__sort_lt(*j, *i)) { \ + tmp = *i; *i = *j; *j = tmp; \ + do_swap = 1; \ + } \ + } \ + } while (do_swap || gap > 2); \ + if (gap != 1) __ks_insertsort_##name(a, a + n); \ + } \ + void ks_introsort_##name(size_t n, type_t a[]) \ + { \ + int d; \ + ks_isort_stack_t *top, *stack; \ + type_t rp, swap_tmp; \ + type_t *s, *t, *i, *j, *k; \ + \ + if (n < 1) return; \ + else if (n == 2) { \ + if (__sort_lt(a[1], a[0])) { swap_tmp = a[0]; a[0] = a[1]; a[1] = swap_tmp; } \ + return; \ + } \ + for (d = 2; 1ul<<d < n; ++d); \ + stack = (ks_isort_stack_t*)malloc(sizeof(ks_isort_stack_t) * ((sizeof(size_t)*d)+2)); \ + top = stack; s = a; t = a + (n-1); d <<= 1; \ + while (1) { \ + if (s < t) { \ + if (--d == 0) { \ + ks_combsort_##name(t - s + 1, s); \ + t = s; \ + continue; \ + } \ + i = s; j = t; k = i + ((j-i)>>1) + 1; \ + if (__sort_lt(*k, *i)) { \ + if (__sort_lt(*k, *j)) k = j; \ + } else k = __sort_lt(*j, *i)? i : j; \ + rp = *k; \ + if (k != t) { swap_tmp = *k; *k = *t; *t = swap_tmp; } \ + for (;;) { \ + do ++i; while (__sort_lt(*i, rp)); \ + do --j; while (i <= j && __sort_lt(rp, *j)); \ + if (j <= i) break; \ + swap_tmp = *i; *i = *j; *j = swap_tmp; \ + } \ + swap_tmp = *i; *i = *t; *t = swap_tmp; \ + if (i-s > t-i) { \ + if (i-s > 16) { top->left = s; top->right = i-1; top->depth = d; ++top; } \ + s = t-i > 16? i+1 : t; \ + } else { \ + if (t-i > 16) { top->left = i+1; top->right = t; top->depth = d; ++top; } \ + t = i-s > 16? i-1 : s; \ + } \ + } else { \ + if (top == stack) { \ + free(stack); \ + __ks_insertsort_##name(a, a+n); \ + return; \ + } else { --top; s = (type_t*)top->left; t = (type_t*)top->right; d = top->depth; } \ + } \ + } \ + } \ + /* This function is adapted from: http://ndevilla.free.fr/median/ */ \ + /* 0 <= kk < n */ \ + type_t ks_ksmall_##name(size_t n, type_t arr[], size_t kk) \ + { \ + type_t *low, *high, *k, *ll, *hh, *mid; \ + low = arr; high = arr + n - 1; k = arr + kk; \ + for (;;) { \ + if (high <= low) return *k; \ + if (high == low + 1) { \ + if (__sort_lt(*high, *low)) KSORT_SWAP(type_t, *low, *high); \ + return *k; \ + } \ + mid = low + (high - low) / 2; \ + if (__sort_lt(*high, *mid)) KSORT_SWAP(type_t, *mid, *high); \ + if (__sort_lt(*high, *low)) KSORT_SWAP(type_t, *low, *high); \ + if (__sort_lt(*low, *mid)) KSORT_SWAP(type_t, *mid, *low); \ + KSORT_SWAP(type_t, *mid, *(low+1)); \ + ll = low + 1; hh = high; \ + for (;;) { \ + do ++ll; while (__sort_lt(*ll, *low)); \ + do --hh; while (__sort_lt(*low, *hh)); \ + if (hh < ll) break; \ + KSORT_SWAP(type_t, *ll, *hh); \ + } \ + KSORT_SWAP(type_t, *low, *hh); \ + if (hh <= k) low = ll; \ + if (hh >= k) high = hh - 1; \ + } \ + } \ + void ks_shuffle_##name(size_t n, type_t a[]) \ + { \ + int i, j; \ + for (i = n; i > 1; --i) { \ + type_t tmp; \ + j = (int)(drand48() * i); \ + tmp = a[j]; a[j] = a[i-1]; a[i-1] = tmp; \ + } \ + } + +#define ks_mergesort(name, n, a, t) ks_mergesort_##name(n, a, t) +#define ks_introsort(name, n, a) ks_introsort_##name(n, a) +#define ks_combsort(name, n, a) ks_combsort_##name(n, a) +#define ks_heapsort(name, n, a) ks_heapsort_##name(n, a) +#define ks_heapmake(name, n, a) ks_heapmake_##name(n, a) +#define ks_heapadjust(name, i, n, a) ks_heapadjust_##name(i, n, a) +#define ks_ksmall(name, n, a, k) ks_ksmall_##name(n, a, k) +#define ks_shuffle(name, n, a) ks_shuffle_##name(n, a) + +#define ks_lt_generic(a, b) ((a) < (b)) +#define ks_lt_str(a, b) (strcmp((a), (b)) < 0) + +typedef const char *ksstr_t; + +#define KSORT_INIT_GENERIC(type_t) KSORT_INIT(type_t, type_t, ks_lt_generic) +#define KSORT_INIT_STR KSORT_INIT(str, ksstr_t, ks_lt_str) + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/kstring.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,270 @@ +/* The MIT License + + Copyright (C) 2011 by Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +#ifndef KSTRING_H +#define KSTRING_H + +#include <stdlib.h> +#include <string.h> +#include <stdarg.h> +#include <stdint.h> +#include <stdio.h> + +#ifndef kroundup32 +#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x)) +#endif + +#if __GNUC__ > 2 || (__GNUC__ == 2 && __GNUC_MINOR__ > 4) +#define KS_ATTR_PRINTF(fmt, arg) __attribute__((__format__ (__printf__, fmt, arg))) +#else +#define KS_ATTR_PRINTF(fmt, arg) +#endif + + +/* kstring_t is a simple non-opaque type whose fields are likely to be + * used directly by user code (but see also ks_str() and ks_len() below). + * A kstring_t object is initialised by either of + * kstring_t str = { 0, 0, NULL }; + * kstring_t str; ...; str.l = str.m = 0; str.s = NULL; + * and either ownership of the underlying buffer should be given away before + * the object disappears (see ks_release() below) or the kstring_t should be + * destroyed with free(str.s); */ +#ifndef KSTRING_T +#define KSTRING_T kstring_t +typedef struct __kstring_t { + size_t l, m; + char *s; +} kstring_t; +#endif + +typedef struct { + uint64_t tab[4]; + int sep, finished; + const char *p; // end of the current token +} ks_tokaux_t; + +#ifdef __cplusplus +extern "C" { +#endif + + int kvsprintf(kstring_t *s, const char *fmt, va_list ap) KS_ATTR_PRINTF(2,0); + int ksprintf(kstring_t *s, const char *fmt, ...) KS_ATTR_PRINTF(2,3); + int ksplit_core(char *s, int delimiter, int *_max, int **_offsets); + char *kstrstr(const char *str, const char *pat, int **_prep); + char *kstrnstr(const char *str, const char *pat, int n, int **_prep); + void *kmemmem(const void *_str, int n, const void *_pat, int m, int **_prep); + + /* kstrtok() is similar to strtok_r() except that str is not + * modified and both str and sep can be NULL. For efficiency, it is + * actually recommended to set both to NULL in the subsequent calls + * if sep is not changed. */ + char *kstrtok(const char *str, const char *sep, ks_tokaux_t *aux); + +#ifdef __cplusplus +} +#endif + +static inline int ks_resize(kstring_t *s, size_t size) +{ + if (s->m < size) { + char *tmp; + s->m = size; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return -1; + } + return 0; +} + +static inline char *ks_str(kstring_t *s) +{ + return s->s; +} + +static inline size_t ks_len(kstring_t *s) +{ + return s->l; +} + +// Give ownership of the underlying buffer away to something else (making +// that something else responsible for freeing it), leaving the kstring_t +// empty and ready to be used again, or ready to go out of scope without +// needing free(str.s) to prevent a memory leak. +static inline char *ks_release(kstring_t *s) +{ + char *ss = s->s; + s->l = s->m = 0; + s->s = NULL; + return ss; +} + +static inline int kputsn(const char *p, int l, kstring_t *s) +{ + if (s->l + l + 1 >= s->m) { + char *tmp; + s->m = s->l + l + 2; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return EOF; + } + memcpy(s->s + s->l, p, l); + s->l += l; + s->s[s->l] = 0; + return l; +} + +static inline int kputs(const char *p, kstring_t *s) +{ + return kputsn(p, strlen(p), s); +} + +static inline int kputc(int c, kstring_t *s) +{ + if (s->l + 1 >= s->m) { + char *tmp; + s->m = s->l + 2; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return EOF; + } + s->s[s->l++] = c; + s->s[s->l] = 0; + return c; +} + +static inline int kputc_(int c, kstring_t *s) +{ + if (s->l + 1 > s->m) { + char *tmp; + s->m = s->l + 1; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return EOF; + } + s->s[s->l++] = c; + return 1; +} + +static inline int kputsn_(const void *p, int l, kstring_t *s) +{ + if (s->l + l > s->m) { + char *tmp; + s->m = s->l + l; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return EOF; + } + memcpy(s->s + s->l, p, l); + s->l += l; + return l; +} + +static inline int kputw(int c, kstring_t *s) +{ + char buf[16]; + int i, l = 0; + unsigned int x = c; + if (c < 0) x = -x; + do { buf[l++] = x%10 + '0'; x /= 10; } while (x > 0); + if (c < 0) buf[l++] = '-'; + if (s->l + l + 1 >= s->m) { + char *tmp; + s->m = s->l + l + 2; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return EOF; + } + for (i = l - 1; i >= 0; --i) s->s[s->l++] = buf[i]; + s->s[s->l] = 0; + return 0; +} + +static inline int kputuw(unsigned c, kstring_t *s) +{ + char buf[16]; + int l, i; + unsigned x; + if (c == 0) return kputc('0', s); + for (l = 0, x = c; x > 0; x /= 10) buf[l++] = x%10 + '0'; + if (s->l + l + 1 >= s->m) { + char *tmp; + s->m = s->l + l + 2; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return EOF; + } + for (i = l - 1; i >= 0; --i) s->s[s->l++] = buf[i]; + s->s[s->l] = 0; + return 0; +} + +static inline int kputl(long c, kstring_t *s) +{ + char buf[32]; + int i, l = 0; + unsigned long x = c; + if (c < 0) x = -x; + do { buf[l++] = x%10 + '0'; x /= 10; } while (x > 0); + if (c < 0) buf[l++] = '-'; + if (s->l + l + 1 >= s->m) { + char *tmp; + s->m = s->l + l + 2; + kroundup32(s->m); + if ((tmp = (char*)realloc(s->s, s->m))) + s->s = tmp; + else + return EOF; + } + for (i = l - 1; i >= 0; --i) s->s[s->l++] = buf[i]; + s->s[s->l] = 0; + return 0; +} + +/* + * Returns 's' split by delimiter, with *n being the number of components; + * NULL on failue. + */ +static inline int *ksplit(kstring_t *s, int delimiter, int *n) +{ + int max = 0, *offsets = 0; + *n = ksplit_core(s->s, delimiter, &max, &offsets); + return offsets; +} + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/regidx.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,147 @@ +/* + Copyright (C) 2014 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + + Permission is hereby granted, free of charge, to any person obtaining a copy + of this software and associated documentation files (the "Software"), to deal + in the Software without restriction, including without limitation the rights + to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + copies of the Software, and to permit persons to whom the Software is + furnished to do so, subject to the following conditions: + + The above copyright notice and this permission notice shall be included in + all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + THE SOFTWARE. +*/ + +/* + Regions indexing with an optional payload. Inspired by samtools/bedidx.c. + This code is intended as future replacement of bcf_sr_regions_t. + + Example of usage: + + // Init the parser and print regions. In this example the payload is a + // pointer to a string. For the description of parse_custom and + // free_custom functions, see regidx_parse_f and regidx_free_f below, + // and for working example see test/test-regidx.c. + regidx_t *idx = regidx_init(in_fname,parse_custom,free_custom,sizeof(char*),NULL); + + // Query overlap with chr:from-to + regitr_t itr; + if ( regidx_overlap(idx, chr,from,to, &itr) ) printf("There is an overlap!\n"); + + while ( REGITR_OVERLAP(itr,from,to) ) + { + printf("[%d,%d] overlaps with [%d,%d], payload=%s\n", from,to, + REGITR_START(itr), REGITR_END(itr), REGITR_PAYLOAD(itr,char*)); + itr.i++; + } + + regidx_destroy(regs); +*/ + +#ifndef HTSLIB_REGIDX_H +#define HTSLIB_REGIDX_H + +#include <stdio.h> +#include <inttypes.h> + +typedef struct _regidx_t regidx_t; +typedef struct +{ + uint32_t start, end; +} +reg_t; +typedef struct +{ + int i, n; + reg_t *reg; + void *payload; +} +regitr_t; + +#define REGITR_START(itr) (itr).reg[(itr).i].start +#define REGITR_END(itr) (itr).reg[(itr).i].end +#define REGITR_PAYLOAD(itr,type_t) ((type_t*)(itr).payload)[(itr).i] +#define REGITR_OVERLAP(itr,from,to) (itr.i < itr.n && REGITR_START(itr)<=to && REGITR_END(itr)>=from ) + +/* + * regidx_parse_f - Function to parse one input line, such as regidx_parse_bed + * or regidx_parse_tab below. The function is expected to set `chr_from` and + * `chr_to` to point to first and last character of chromosome name and set + * coordinates `reg->start` and `reg->end` (0-based, inclusive). If + * regidx_init() was called with non-zero payload_size, the `payload` points + * to a memory location of the payload_size and `usr` is data passed to + * regidx_init(). Any memory allocated by the function will be freed by + * regidx_free_f on regidx_destroy(). + * + * Return value: 0 on success, -1 to skip a record, -2 on fatal error. + */ +typedef int (*regidx_parse_f)(const char *line, char **chr_beg, char **chr_end, reg_t *reg, void *payload, void *usr); +typedef void (*regidx_free_f)(void *payload); + +int regidx_parse_bed(const char*,char**,char**,reg_t*,void*,void*); // CHROM,FROM,TO (0-based,right-open) +int regidx_parse_tab(const char*,char**,char**,reg_t*,void*,void*); // CHROM,POS (1-based, inclusive) + +/* + * regidx_init() - creates new index + * @param fname: input file name or NULL if regions will be added one-by-one via regidx_insert() + * @param parsef: regidx_parse_bed, regidx_parse_tab or see description of regidx_parse_f. If NULL, + * the format will be autodected, currently either regidx_parse_tab (the default) or + * regidx_parse_bed (file must be named 'bed' or 'bed.gz') will be used. Note that + * the exact autodetection algorithm will change. + * @param freef: NULL or see description of regidx_parse_f + * @param payload_size: 0 with regidx_parse_bed, regidx_parse_tab or see regidx_parse_f + * @param usr: optional user data passed to regidx_parse_f + * + * Returns index on success or NULL on error. + */ +regidx_t *regidx_init(const char *fname, regidx_parse_f parsef, regidx_free_f freef, size_t payload_size, void *usr); + +/* + * regidx_destroy() - free memory allocated by regidx_init + */ +void regidx_destroy(regidx_t *idx); + +/* + * regidx_overlap() - check overlap of the location chr:from-to with regions + * @param start,end: 0-based start, end coordinate (inclusive) + * @param itr: pointer to iterator, can be NULL if not needed + * + * Returns 0 if there is no overlap or 1 if overlap is found. The overlapping + * regions can be iterated as shown in the example above. + */ +int regidx_overlap(regidx_t *idx, const char *chr, uint32_t start, uint32_t end, regitr_t *itr); + +/* + * regidx_insert() - add a new region. + * + * After last region has been added, call regidx_insert(idx,NULL) to + * build the index. + * + * Returns 0 on success or -1 on error. + */ +int regidx_insert(regidx_t *idx, char *line); + +/* + * regidx_seq_names() - return list of all sequence names + */ +char **regidx_seq_names(regidx_t *idx, int *n); + +/* + * regidx_seq_nregs() - number of regions + * regidx_nregs() - total number of regions + */ +int regidx_seq_nregs(regidx_t *idx, const char *seq); +int regidx_nregs(regidx_t *idx); + +#endif +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/sam.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,426 @@ +/* sam.h -- SAM and BAM file I/O and manipulation. + + Copyright (C) 2008, 2009, 2013-2014 Genome Research Ltd. + Copyright (C) 2010, 2012, 2013 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_SAM_H +#define HTSLIB_SAM_H + +#include <stdint.h> +#include "hts.h" + +/********************** + *** SAM/BAM header *** + **********************/ + +/*! @typedef + @abstract Structure for the alignment header. + @field n_targets number of reference sequences + @field l_text length of the plain text in the header + @field target_len lengths of the reference sequences + @field target_name names of the reference sequences + @field text plain text + @field sdict header dictionary + */ + +typedef struct { + int32_t n_targets, ignore_sam_err; + uint32_t l_text; + uint32_t *target_len; + int8_t *cigar_tab; + char **target_name; + char *text; + void *sdict; +} bam_hdr_t; + +/**************************** + *** CIGAR related macros *** + ****************************/ + +#define BAM_CMATCH 0 +#define BAM_CINS 1 +#define BAM_CDEL 2 +#define BAM_CREF_SKIP 3 +#define BAM_CSOFT_CLIP 4 +#define BAM_CHARD_CLIP 5 +#define BAM_CPAD 6 +#define BAM_CEQUAL 7 +#define BAM_CDIFF 8 +#define BAM_CBACK 9 + +#define BAM_CIGAR_STR "MIDNSHP=XB" +#define BAM_CIGAR_SHIFT 4 +#define BAM_CIGAR_MASK 0xf +#define BAM_CIGAR_TYPE 0x3C1A7 + +#define bam_cigar_op(c) ((c)&BAM_CIGAR_MASK) +#define bam_cigar_oplen(c) ((c)>>BAM_CIGAR_SHIFT) +#define bam_cigar_opchr(c) (BAM_CIGAR_STR[bam_cigar_op(c)]) +#define bam_cigar_gen(l, o) ((l)<<BAM_CIGAR_SHIFT|(o)) + +/* bam_cigar_type returns a bit flag with: + * bit 1 set if the cigar operation consumes the query + * bit 2 set if the cigar operation consumes the reference + * + * For reference, the unobfuscated truth table for this function is: + * BAM_CIGAR_TYPE QUERY REFERENCE + * -------------------------------- + * BAM_CMATCH 1 1 + * BAM_CINS 1 0 + * BAM_CDEL 0 1 + * BAM_CREF_SKIP 0 1 + * BAM_CSOFT_CLIP 1 0 + * BAM_CHARD_CLIP 0 0 + * BAM_CPAD 0 0 + * BAM_CEQUAL 1 1 + * BAM_CDIFF 1 1 + * BAM_CBACK 0 0 + * -------------------------------- + */ +#define bam_cigar_type(o) (BAM_CIGAR_TYPE>>((o)<<1)&3) // bit 1: consume query; bit 2: consume reference + +/*! @abstract the read is paired in sequencing, no matter whether it is mapped in a pair */ +#define BAM_FPAIRED 1 +/*! @abstract the read is mapped in a proper pair */ +#define BAM_FPROPER_PAIR 2 +/*! @abstract the read itself is unmapped; conflictive with BAM_FPROPER_PAIR */ +#define BAM_FUNMAP 4 +/*! @abstract the mate is unmapped */ +#define BAM_FMUNMAP 8 +/*! @abstract the read is mapped to the reverse strand */ +#define BAM_FREVERSE 16 +/*! @abstract the mate is mapped to the reverse strand */ +#define BAM_FMREVERSE 32 +/*! @abstract this is read1 */ +#define BAM_FREAD1 64 +/*! @abstract this is read2 */ +#define BAM_FREAD2 128 +/*! @abstract not primary alignment */ +#define BAM_FSECONDARY 256 +/*! @abstract QC failure */ +#define BAM_FQCFAIL 512 +/*! @abstract optical or PCR duplicate */ +#define BAM_FDUP 1024 +/*! @abstract supplementary alignment */ +#define BAM_FSUPPLEMENTARY 2048 + +/************************* + *** Alignment records *** + *************************/ + +/*! @typedef + @abstract Structure for core alignment information. + @field tid chromosome ID, defined by bam_hdr_t + @field pos 0-based leftmost coordinate + @field bin bin calculated by bam_reg2bin() + @field qual mapping quality + @field l_qname length of the query name + @field flag bitwise flag + @field n_cigar number of CIGAR operations + @field l_qseq length of the query sequence (read) + @field mtid chromosome ID of next read in template, defined by bam_hdr_t + @field mpos 0-based leftmost coordinate of next read in template + */ +typedef struct { + int32_t tid; + int32_t pos; + uint32_t bin:16, qual:8, l_qname:8; + uint32_t flag:16, n_cigar:16; + int32_t l_qseq; + int32_t mtid; + int32_t mpos; + int32_t isize; +} bam1_core_t; + +/*! @typedef + @abstract Structure for one alignment. + @field core core information about the alignment + @field l_data current length of bam1_t::data + @field m_data maximum length of bam1_t::data + @field data all variable-length data, concatenated; structure: qname-cigar-seq-qual-aux + + @discussion Notes: + + 1. qname is zero tailing and core.l_qname includes the tailing '\0'. + 2. l_qseq is calculated from the total length of an alignment block + on reading or from CIGAR. + 3. cigar data is encoded 4 bytes per CIGAR operation. + 4. seq is nybble-encoded according to bam_nt16_table. + */ +typedef struct { + bam1_core_t core; + int l_data, m_data; + uint8_t *data; +#ifndef BAM_NO_ID + uint64_t id; +#endif +} bam1_t; + +/*! @function + @abstract Get whether the query is on the reverse strand + @param b pointer to an alignment + @return boolean true if query is on the reverse strand + */ +#define bam_is_rev(b) (((b)->core.flag&BAM_FREVERSE) != 0) +/*! @function + @abstract Get whether the query's mate is on the reverse strand + @param b pointer to an alignment + @return boolean true if query's mate on the reverse strand + */ +#define bam_is_mrev(b) (((b)->core.flag&BAM_FMREVERSE) != 0) +/*! @function + @abstract Get the name of the query + @param b pointer to an alignment + @return pointer to the name string, null terminated + */ +#define bam_get_qname(b) ((char*)(b)->data) +/*! @function + @abstract Get the CIGAR array + @param b pointer to an alignment + @return pointer to the CIGAR array + + @discussion In the CIGAR array, each element is a 32-bit integer. The + lower 4 bits gives a CIGAR operation and the higher 28 bits keep the + length of a CIGAR. + */ +#define bam_get_cigar(b) ((uint32_t*)((b)->data + (b)->core.l_qname)) +/*! @function + @abstract Get query sequence + @param b pointer to an alignment + @return pointer to sequence + + @discussion Each base is encoded in 4 bits: 1 for A, 2 for C, 4 for G, + 8 for T and 15 for N. Two bases are packed in one byte with the base + at the higher 4 bits having smaller coordinate on the read. It is + recommended to use bam_seqi() macro to get the base. + */ +#define bam_get_seq(b) ((b)->data + ((b)->core.n_cigar<<2) + (b)->core.l_qname) +/*! @function + @abstract Get query quality + @param b pointer to an alignment + @return pointer to quality string + */ +#define bam_get_qual(b) ((b)->data + ((b)->core.n_cigar<<2) + (b)->core.l_qname + (((b)->core.l_qseq + 1)>>1)) +/*! @function + @abstract Get auxiliary data + @param b pointer to an alignment + @return pointer to the concatenated auxiliary data + */ +#define bam_get_aux(b) ((b)->data + ((b)->core.n_cigar<<2) + (b)->core.l_qname + (((b)->core.l_qseq + 1)>>1) + (b)->core.l_qseq) +/*! @function + @abstract Get length of auxiliary data + @param b pointer to an alignment + @return length of the concatenated auxiliary data + */ +#define bam_get_l_aux(b) ((b)->l_data - ((b)->core.n_cigar<<2) - (b)->core.l_qname - (b)->core.l_qseq - (((b)->core.l_qseq + 1)>>1)) +/*! @function + @abstract Get a base on read + @param s Query sequence returned by bam_get_seq() + @param i The i-th position, 0-based + @return 4-bit integer representing the base. + */ +#define bam_seqi(s, i) ((s)[(i)>>1] >> ((~(i)&1)<<2) & 0xf) + +/************************** + *** Exported functions *** + **************************/ + +#ifdef __cplusplus +extern "C" { +#endif + + /*************** + *** BAM I/O *** + ***************/ + + bam_hdr_t *bam_hdr_init(void); + bam_hdr_t *bam_hdr_read(BGZF *fp); + int bam_hdr_write(BGZF *fp, const bam_hdr_t *h); + void bam_hdr_destroy(bam_hdr_t *h); + int bam_name2id(bam_hdr_t *h, const char *ref); + bam_hdr_t* bam_hdr_dup(const bam_hdr_t *h0); + + bam1_t *bam_init1(void); + void bam_destroy1(bam1_t *b); + int bam_read1(BGZF *fp, bam1_t *b); + int bam_write1(BGZF *fp, const bam1_t *b); + bam1_t *bam_copy1(bam1_t *bdst, const bam1_t *bsrc); + bam1_t *bam_dup1(const bam1_t *bsrc); + + int bam_cigar2qlen(int n_cigar, const uint32_t *cigar); + int bam_cigar2rlen(int n_cigar, const uint32_t *cigar); + + /*! + @abstract Calculate the rightmost base position of an alignment on the + reference genome. + + @param b pointer to an alignment + @return the coordinate of the first base after the alignment, 0-based + + @discussion For a mapped read, this is just b->core.pos + bam_cigar2rlen. + For an unmapped read (either according to its flags or if it has no cigar + string), we return b->core.pos + 1 by convention. + */ + int32_t bam_endpos(const bam1_t *b); + + int bam_str2flag(const char *str); /** returns negative value on error */ + char *bam_flag2str(int flag); /** The string must be freed by the user */ + + /************************* + *** BAM/CRAM indexing *** + *************************/ + + // These BAM iterator functions work only on BAM files. To work with either + // BAM or CRAM files use the sam_index_load() & sam_itr_*() functions. + #define bam_itr_destroy(iter) hts_itr_destroy(iter) + #define bam_itr_queryi(idx, tid, beg, end) sam_itr_queryi(idx, tid, beg, end) + #define bam_itr_querys(idx, hdr, region) sam_itr_querys(idx, hdr, region) + #define bam_itr_next(htsfp, itr, r) hts_itr_next((htsfp)->fp.bgzf, (itr), (r), 0) + + // Load .csi or .bai BAM index file. + #define bam_index_load(fn) hts_idx_load((fn), HTS_FMT_BAI) + + int bam_index_build(const char *fn, int min_shift); + + // Load BAM (.csi or .bai) or CRAM (.crai) index file. + hts_idx_t *sam_index_load(htsFile *fp, const char *fn); + + #define sam_itr_destroy(iter) hts_itr_destroy(iter) + hts_itr_t *sam_itr_queryi(const hts_idx_t *idx, int tid, int beg, int end); + hts_itr_t *sam_itr_querys(const hts_idx_t *idx, bam_hdr_t *hdr, const char *region); + #define sam_itr_next(htsfp, itr, r) hts_itr_next((htsfp)->fp.bgzf, (itr), (r), (htsfp)) + + /*************** + *** SAM I/O *** + ***************/ + + #define sam_open(fn, mode) (hts_open((fn), (mode))) + #define sam_close(fp) hts_close(fp) + + int sam_open_mode(char *mode, const char *fn, const char *format); + + typedef htsFile samFile; + bam_hdr_t *sam_hdr_parse(int l_text, const char *text); + bam_hdr_t *sam_hdr_read(samFile *fp); + int sam_hdr_write(samFile *fp, const bam_hdr_t *h); + + int sam_parse1(kstring_t *s, bam_hdr_t *h, bam1_t *b); + int sam_format1(const bam_hdr_t *h, const bam1_t *b, kstring_t *str); + int sam_read1(samFile *fp, bam_hdr_t *h, bam1_t *b); + int sam_write1(samFile *fp, const bam_hdr_t *h, const bam1_t *b); + + /************************************* + *** Manipulating auxiliary fields *** + *************************************/ + + uint8_t *bam_aux_get(const bam1_t *b, const char tag[2]); + int32_t bam_aux2i(const uint8_t *s); + double bam_aux2f(const uint8_t *s); + char bam_aux2A(const uint8_t *s); + char *bam_aux2Z(const uint8_t *s); + + void bam_aux_append(bam1_t *b, const char tag[2], char type, int len, uint8_t *data); + int bam_aux_del(bam1_t *b, uint8_t *s); + +#ifdef __cplusplus +} +#endif + +/************************** + *** Pileup and Mpileup *** + **************************/ + +#if !defined(BAM_NO_PILEUP) + +/*! @typedef + @abstract Structure for one alignment covering the pileup position. + @field b pointer to the alignment + @field qpos position of the read base at the pileup site, 0-based + @field indel indel length; 0 for no indel, positive for ins and negative for del + @field level the level of the read in the "viewer" mode + @field is_del 1 iff the base on the padded read is a deletion + @field is_head ??? + @field is_tail ??? + @field is_refskip ??? + @field aux ??? + + @discussion See also bam_plbuf_push() and bam_lplbuf_push(). The + difference between the two functions is that the former does not + set bam_pileup1_t::level, while the later does. Level helps the + implementation of alignment viewers, but calculating this has some + overhead. + */ +typedef struct { + bam1_t *b; + int32_t qpos; + int indel, level; + uint32_t is_del:1, is_head:1, is_tail:1, is_refskip:1, aux:28; +} bam_pileup1_t; + +typedef int (*bam_plp_auto_f)(void *data, bam1_t *b); + +struct __bam_plp_t; +typedef struct __bam_plp_t *bam_plp_t; + +struct __bam_mplp_t; +typedef struct __bam_mplp_t *bam_mplp_t; + +#ifdef __cplusplus +extern "C" { +#endif + + /** + * bam_plp_init() - sets an iterator over multiple + * @func: see mplp_func in bam_plcmd.c in samtools for an example. Expected return + * status: 0 on success, -1 on end, < -1 on non-recoverable errors + * @data: user data to pass to @func + */ + bam_plp_t bam_plp_init(bam_plp_auto_f func, void *data); + void bam_plp_destroy(bam_plp_t iter); + int bam_plp_push(bam_plp_t iter, const bam1_t *b); + const bam_pileup1_t *bam_plp_next(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp); + const bam_pileup1_t *bam_plp_auto(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp); + void bam_plp_set_maxcnt(bam_plp_t iter, int maxcnt); + void bam_plp_reset(bam_plp_t iter); + + bam_mplp_t bam_mplp_init(int n, bam_plp_auto_f func, void **data); + /** + * bam_mplp_init_overlaps() - if called, mpileup will detect overlapping + * read pairs and for each base pair set the base quality of the + * lower-quality base to zero, thus effectively discarding it from + * calling. If the two bases are identical, the quality of the other base + * is increased to the sum of their qualities (capped at 200), otherwise + * it is multiplied by 0.8. + */ + void bam_mplp_init_overlaps(bam_mplp_t iter); + void bam_mplp_destroy(bam_mplp_t iter); + void bam_mplp_set_maxcnt(bam_mplp_t iter, int maxcnt); + int bam_mplp_auto(bam_mplp_t iter, int *_tid, int *_pos, int *n_plp, const bam_pileup1_t **plp); + +#ifdef __cplusplus +} +#endif + +#endif // ~!defined(BAM_NO_PILEUP) + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/synced_bcf_reader.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,301 @@ +/* synced_bcf_reader.h -- stream through multiple VCF files. + + Copyright (C) 2012-2014 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +/* + The synced_bcf_reader allows to keep multiple VCFs open and stream them + using the next_line iterator in a seamless matter without worrying about + chromosomes and synchronizing the sites. This is used by vcfcheck to + compare multiple VCFs simultaneously and is used also for merging, + creating intersections, etc. + + The synced_bcf_reader also provides API for reading indexed BCF/VCF, + hiding differences in BCF/VCF opening, indexing and reading. + + + Example of usage: + + bcf_srs_t *sr = bcf_sr_init(); + for (i=0; i<nfiles; i++) + bcf_sr_add_reader(sr,files[i]); + while ( bcf_sr_next_line(sr) ) + { + for (i=0; i<nfiles; i++) + { + bcf1_t *line = bcf_sr_get_line(sr,i); + ... + } + } + bcf_sr_destroy(sr); +*/ + +#ifndef HTSLIB_SYNCED_BCF_READER_H +#define HTSLIB_SYNCED_BCF_READER_H + +#include "hts.h" +#include "vcf.h" +#include "tbx.h" + +// How should be treated sites with the same position but different alleles +#define COLLAPSE_NONE 0 // require the exact same set of alleles in all files +#define COLLAPSE_SNPS 1 // allow different alleles, as long as they all are SNPs +#define COLLAPSE_INDELS 2 // the same as above, but with indels +#define COLLAPSE_ANY 4 // any combination of alleles can be returned by bcf_sr_next_line() +#define COLLAPSE_SOME 8 // at least some of the ALTs must match +#define COLLAPSE_BOTH (COLLAPSE_SNPS|COLLAPSE_INDELS) + +typedef struct _bcf_sr_regions_t +{ + // for reading from tabix-indexed file (big data) + tbx_t *tbx; // tabix index + hts_itr_t *itr; // tabix iterator + kstring_t line; // holder of the current line, set only when reading from tabix-indexed files + htsFile *file; + char *fname; + int is_bin; // is open in binary mode (tabix access) + char **als; // parsed alleles if targets_als set and _regions_match_alleles called + kstring_t als_str; // block of parsed alleles + int nals, mals; // number of set alleles and the size of allocated array + int als_type; // alleles type, currently VCF_SNP or VCF_INDEL + + // user handler to deal with skipped regions without a counterpart in VCFs + void (*missed_reg_handler)(struct _bcf_sr_regions_t *, void *); + void *missed_reg_data; + + // for in-memory regions (small data) + struct _region_t *regs; // the regions + + // shared by both tabix-index and in-memory regions + void *seq_hash; // keys: sequence names, values: index to seqs + char **seq_names; // sequence names + int nseqs; // number of sequences (chromosomes) in the file + int iseq; // current position: chr name, index to snames + int start, end; // current position: start, end of the region (0-based) + int prev_seq, prev_start; +} +bcf_sr_regions_t; + +typedef struct +{ + htsFile *file; + tbx_t *tbx_idx; + hts_idx_t *bcf_idx; + bcf_hdr_t *header; + hts_itr_t *itr; + const char *fname; + bcf1_t **buffer; // cached VCF records. First is the current record synced across the reader + int nbuffer, mbuffer; // number of cached records (including the current record); number of allocated records + int nfilter_ids, *filter_ids; // -1 for ".", otherwise filter id as returned by bcf_id2int + int *samples, n_smpl; // list of columns in the order consistent with bcf_srs_t.samples +} +bcf_sr_t; + +typedef enum +{ + open_failed, not_bgzf, idx_load_failed, file_type_error, api_usage_error, + header_error +} +bcf_sr_error; + +typedef struct +{ + // Parameters controlling the logic + int collapse; // How should the duplicate sites be treated. One of the COLLAPSE_* types above. + char *apply_filters; // If set, sites where none of the FILTER strings is listed + // will be skipped. Active only at the time of + // initialization, that is during the add_reader() + // calls. Therefore, each reader can be initialized with different + // filters. + int require_index; // Some tools do not need random access + int max_unpack; // When reading VCFs and knowing some fields will not be needed, boost performance of vcf_parse1 + int *has_line; // Corresponds to return value of bcf_sr_next_line but is not limited by sizeof(int). Use bcf_sr_has_line macro to query. + bcf_sr_error errnum; + + // Auxiliary data + bcf_sr_t *readers; + int nreaders; + int streaming; // reading mode: index-jumping or streaming + int explicit_regs; // was the list of regions se by bcf_sr_set_regions or guessed from tabix index? + char **samples; // List of samples + bcf_sr_regions_t *regions, *targets; // see bcf_sr_set_[targets|regions] for description + int targets_als; // subset to targets not only by position but also by alleles? + int targets_exclude; + kstring_t tmps; + int n_smpl; +} +bcf_srs_t; + +#ifdef __cplusplus +extern "C" { +#endif + +/** Init bcf_srs_t struct */ +bcf_srs_t *bcf_sr_init(void); + +/** Destroy bcf_srs_t struct */ +void bcf_sr_destroy(bcf_srs_t *readers); + +char *bcf_sr_strerror(int errnum); + + +/** + * bcf_sr_add_reader() - open new reader + * @readers: holder of the open readers + * @fname: the VCF file + * + * Returns 1 if the call succeeded, or 0 on error. + * + * See also the bcf_srs_t data structure for parameters controlling + * the reader's logic. + */ +int bcf_sr_add_reader(bcf_srs_t *readers, const char *fname); +void bcf_sr_remove_reader(bcf_srs_t *files, int i); + +/** + * bcf_sr_next_line() - the iterator + * @readers: holder of the open readers + * + * Returns the number of readers which have the current line + * (bcf_sr_t.buffer[0]) set at this position. Use the bcf_sr_has_line macro to + * determine which of the readers are set. + */ +int bcf_sr_next_line(bcf_srs_t *readers); +#define bcf_sr_has_line(readers, i) (readers)->has_line[i] +#define bcf_sr_get_line(_readers, i) ((_readers)->has_line[i] ? ((_readers)->readers[i].buffer[0]) : NULL) +#define bcf_sr_region_done(_readers,i) (!(_readers)->has_line[i] && !(_readers)->readers[i].nbuffer ? 1 : 0) +#define bcf_sr_get_header(_readers, i) (_readers)->readers[i].header +#define bcf_sr_get_reader(_readers, i) &((_readers)->readers[i]) + +/** + * bcf_sr_seek() - set all readers to selected position + * @seq: sequence name; NULL to seek to start + * @pos: 0-based coordinate + */ +int bcf_sr_seek(bcf_srs_t *readers, const char *seq, int pos); + +/** + * bcf_sr_set_samples() - sets active samples + * @readers: holder of the open readers + * @samples: this can be one of: file name with one sample per line; + * or column-separated list of samples; or '-' for a list of + * samples shared by all files. If first character is the + * exclamation mark, all but the listed samples are included. + * @is_file: 0: list of samples; 1: file with sample names + * + * Returns 1 if the call succeeded, or 0 on error. + */ +int bcf_sr_set_samples(bcf_srs_t *readers, const char *samples, int is_file); + +/** + * bcf_sr_set_targets(), bcf_sr_set_regions() - init targets/regions + * @readers: holder of the open readers + * @targets: list of regions, one-based and inclusive. + * @is_fname: 0: targets is a comma-separated list of regions (chr,chr:from-to) + * 1: targets is a tabix indexed file with a list of regions + * (<chr,pos> or <chr,from,to>) + * + * Returns 0 if the call succeeded, or -1 on error. + * + * Both functions behave the same way, unlisted positions will be skipped by + * bcf_sr_next_line(). However, there is an important difference: regions use + * index to jump to desired positions while targets streams the whole files + * and merely skip unlisted positions. + * + * Moreover, bcf_sr_set_targets() accepts an optional parameter $alleles which + * is intepreted as a 1-based column index in the tab-delimited file where + * alleles are listed. This in principle enables to perform the COLLAPSE_* + * logic also with tab-delimited files. However, the current implementation + * considers the alleles merely as a suggestion for prioritizing one of possibly + * duplicate VCF lines. It is up to the caller to examine targets->als if + * perfect match is sought after. Note that the duplicate positions in targets + * file are currently not supported. + * Targets (but not regions) can be prefixed with "^" to request logical complement, + * for example "^X,Y,MT" indicates that sequences X, Y and MT should be skipped. + */ +int bcf_sr_set_targets(bcf_srs_t *readers, const char *targets, int is_file, int alleles); +int bcf_sr_set_regions(bcf_srs_t *readers, const char *regions, int is_file); + + + +/* + * bcf_sr_regions_init() + * @regions: regions can be either a comma-separated list of regions + * (chr|chr:pos|chr:from-to|chr:from-) or VCF, BED, or + * tab-delimited file (the default). Uncompressed files + * are stored in memory while bgzip-compressed and tabix-indexed + * region files are streamed. + * @is_file: 0: regions is a comma-separated list of regions + * (chr|chr:pos|chr:from-to|chr:from-) + * 1: VCF, BED or tab-delimited file + * @chr, from, to: + * Column indexes of chromosome, start position and end position + * in the tab-delimited file. The positions are 1-based and + * inclusive. + * These parameters are ignored when reading from VCF, BED or + * tabix-indexed files. When end position column is not present, + * supply 'from' in place of 'to'. When 'to' is negative, first + * abs(to) will be attempted and if that fails, 'from' will be used + * instead. + */ +bcf_sr_regions_t *bcf_sr_regions_init(const char *regions, int is_file, int chr, int from, int to); +void bcf_sr_regions_destroy(bcf_sr_regions_t *regions); + +/* + * bcf_sr_regions_seek() - seek to the chromosome block + * + * Returns 0 on success or -1 on failure. Sets reg->seq appropriately and + * reg->start,reg->end to -1. + */ +int bcf_sr_regions_seek(bcf_sr_regions_t *regions, const char *chr); + +/* + * bcf_sr_regions_next() - retrieves next region. Returns 0 on success and -1 + * when all regions have been read. The fields reg->seq, reg->start and + * reg->end are filled with the genomic coordinates on succes or with + * NULL,-1,-1 when no region is available. The coordinates are 0-based, + * inclusive. + */ +int bcf_sr_regions_next(bcf_sr_regions_t *reg); + +/* + * bcf_sr_regions_overlap() - checks if the interval <start,end> overlaps any of + * the regions, the coordinates are 0-based, inclusive. The coordinate queries + * must come in ascending order. + * + * Returns 0 if the position is in regions; -1 if the position is not in the + * regions and more regions exist; -2 if not in the regions and there are no more + * regions left. + */ +int bcf_sr_regions_overlap(bcf_sr_regions_t *reg, const char *seq, int start, int end); + +/* + * bcf_sr_regions_flush() - calls repeatedly regs->missed_reg_handler() until + * all remaining records are processed. + */ +void bcf_sr_regions_flush(bcf_sr_regions_t *regs); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/tbx.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,77 @@ +/* tbx.h -- tabix API functions. + + Copyright (C) 2009, 2012-2014 Genome Research Ltd. + Copyright (C) 2010, 2012 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_TBX_H +#define HTSLIB_TBX_H + +#include "hts.h" + +#define TBX_MAX_SHIFT 31 + +#define TBX_GENERIC 0 +#define TBX_SAM 1 +#define TBX_VCF 2 +#define TBX_UCSC 0x10000 + +typedef struct { + int32_t preset; + int32_t sc, bc, ec; // seq col., beg col. and end col. + int32_t meta_char, line_skip; +} tbx_conf_t; + +typedef struct { + tbx_conf_t conf; + hts_idx_t *idx; + void *dict; +} tbx_t; + +extern tbx_conf_t tbx_conf_gff, tbx_conf_bed, tbx_conf_psltbl, tbx_conf_sam, tbx_conf_vcf; + +#ifdef __cplusplus +extern "C" { +#endif + + #define tbx_itr_destroy(iter) hts_itr_destroy(iter) + #define tbx_itr_queryi(tbx, tid, beg, end) hts_itr_query((tbx)->idx, (tid), (beg), (end), tbx_readrec) + #define tbx_itr_querys(tbx, s) hts_itr_querys((tbx)->idx, (s), (hts_name2id_f)(tbx_name2id), (tbx), hts_itr_query, tbx_readrec) + #define tbx_itr_next(htsfp, tbx, itr, r) hts_itr_next(hts_get_bgzfp(htsfp), (itr), (r), (tbx)) + #define tbx_bgzf_itr_next(bgzfp, tbx, itr, r) hts_itr_next((bgzfp), (itr), (r), (tbx)) + + int tbx_name2id(tbx_t *tbx, const char *ss); + + /* Internal helper function used by tbx_itr_next() */ + BGZF *hts_get_bgzfp(htsFile *fp); + int tbx_readrec(BGZF *fp, void *tbxv, void *sv, int *tid, int *beg, int *end); + + int tbx_index_build(const char *fn, int min_shift, const tbx_conf_t *conf); + tbx_t *tbx_index_load(const char *fn); + const char **tbx_seqnames(tbx_t *tbx, int *n); // free the array but not the values + void tbx_destroy(tbx_t *tbx); + +#ifdef __cplusplus +} +#endif + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/vcf.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,883 @@ +/* vcf.h -- VCF/BCF API functions. + + Copyright (C) 2012, 2013 Broad Institute. + Copyright (C) 2012-2014 Genome Research Ltd. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +/* + todo: + - make the function names consistent + - provide calls to abstract away structs as much as possible + */ + +#ifndef HTSLIB_VCF_H +#define HTSLIB_VCF_H + +#include <stdint.h> +#include <limits.h> +#include <assert.h> +#include "hts.h" +#include "kstring.h" + + +/***************** + * Header struct * + *****************/ + +#define BCF_HL_FLT 0 // header line +#define BCF_HL_INFO 1 +#define BCF_HL_FMT 2 +#define BCF_HL_CTG 3 +#define BCF_HL_STR 4 // structured header line TAG=<A=..,B=..> +#define BCF_HL_GEN 5 // generic header line + +#define BCF_HT_FLAG 0 // header type +#define BCF_HT_INT 1 +#define BCF_HT_REAL 2 +#define BCF_HT_STR 3 + +#define BCF_VL_FIXED 0 // variable length +#define BCF_VL_VAR 1 +#define BCF_VL_A 2 +#define BCF_VL_G 3 +#define BCF_VL_R 4 + +/* === Dictionary === + + The header keeps three dictonaries. The first keeps IDs in the + "FILTER/INFO/FORMAT" lines, the second keeps the sequence names and lengths + in the "contig" lines and the last keeps the sample names. bcf_hdr_t::dict[] + is the actual hash table, which is opaque to the end users. In the hash + table, the key is the ID or sample name as a C string and the value is a + bcf_idinfo_t struct. bcf_hdr_t::id[] points to key-value pairs in the hash + table in the order that they appear in the VCF header. bcf_hdr_t::n[] is the + size of the hash table or, equivalently, the length of the id[] arrays. +*/ + +#define BCF_DT_ID 0 // dictionary type +#define BCF_DT_CTG 1 +#define BCF_DT_SAMPLE 2 + +// Complete textual representation of a header line +typedef struct { + int type; // One of the BCF_HL_* type + char *key; // The part before '=', i.e. FILTER/INFO/FORMAT/contig/fileformat etc. + char *value; // Set only for generic lines, NULL for FILTER/INFO, etc. + int nkeys; // Number of structured fields + char **keys, **vals; // The key=value pairs +} bcf_hrec_t; + +typedef struct { + uint32_t info[3]; // stores Number:20, var:4, Type:4, ColType:4 in info[0..2] + // for BCF_HL_FLT,INFO,FMT and contig length in info[0] for BCF_HL_CTG + bcf_hrec_t *hrec[3]; + int id; +} bcf_idinfo_t; + +typedef struct { + const char *key; + const bcf_idinfo_t *val; +} bcf_idpair_t; + +typedef struct { + int32_t n[3]; + bcf_idpair_t *id[3]; + void *dict[3]; // ID dictionary, contig dict and sample dict + char **samples; + bcf_hrec_t **hrec; + int nhrec, dirty; + int ntransl, *transl[2]; // for bcf_translate() + int nsamples_ori; // for bcf_hdr_set_samples() + uint8_t *keep_samples; + kstring_t mem; +} bcf_hdr_t; + +extern uint8_t bcf_type_shift[]; + +/************** + * VCF record * + **************/ + +#define BCF_BT_NULL 0 +#define BCF_BT_INT8 1 +#define BCF_BT_INT16 2 +#define BCF_BT_INT32 3 +#define BCF_BT_FLOAT 5 +#define BCF_BT_CHAR 7 + +#define VCF_REF 0 +#define VCF_SNP 1 +#define VCF_MNP 2 +#define VCF_INDEL 4 +#define VCF_OTHER 8 + +typedef struct { + int type, n; // variant type and the number of bases affected, negative for deletions +} variant_t; + +typedef struct { + int id; // id: numeric tag id, the corresponding string is bcf_hdr_t::id[BCF_DT_ID][$id].key + int n, size, type; // n: number of values per-sample; size: number of bytes per-sample; type: one of BCF_BT_* types + uint8_t *p; // same as vptr and vptr_* in bcf_info_t below + uint32_t p_len; + uint32_t p_off:31, p_free:1; +} bcf_fmt_t; + +typedef struct { + int key; // key: numeric tag id, the corresponding string is bcf_hdr_t::id[BCF_DT_ID][$key].key + int type, len; // type: one of BCF_BT_* types; len: vector length, 1 for scalars + union { + int32_t i; // integer value + float f; // float value + } v1; // only set if $len==1; for easier access + uint8_t *vptr; // pointer to data array in bcf1_t->shared.s, excluding the size+type and tag id bytes + uint32_t vptr_len; // length of the vptr block or, when set, of the vptr_mod block, excluding offset + uint32_t vptr_off:31, // vptr offset, i.e., the size of the INFO key plus size+type bytes + vptr_free:1; // indicates that vptr-vptr_off must be freed; set only when modified and the new + // data block is bigger than the original +} bcf_info_t; + + +#define BCF1_DIRTY_ID 1 +#define BCF1_DIRTY_ALS 2 +#define BCF1_DIRTY_FLT 4 +#define BCF1_DIRTY_INF 8 + +typedef struct { + int m_fmt, m_info, m_id, m_als, m_allele, m_flt; // allocated size (high-water mark); do not change + int n_flt; // Number of FILTER fields + int *flt; // FILTER keys in the dictionary + char *id, *als; // ID and REF+ALT block (\0-seperated) + char **allele; // allele[0] is the REF (allele[] pointers to the als block); all null terminated + bcf_info_t *info; // INFO + bcf_fmt_t *fmt; // FORMAT and individual sample + variant_t *var; // $var and $var_type set only when set_variant_types called + int n_var, var_type; + int shared_dirty; // if set, shared.s must be recreated on BCF output + int indiv_dirty; // if set, indiv.s must be recreated on BCF output +} bcf_dec_t; + + +#define BCF_ERR_CTG_UNDEF 1 +#define BCF_ERR_TAG_UNDEF 2 +#define BCF_ERR_NCOLS 4 + +/* + The bcf1_t structure corresponds to one VCF/BCF line. Reading from VCF file + is slower because the string is first to be parsed, packed into BCF line + (done in vcf_parse), then unpacked into internal bcf1_t structure. If it + is known in advance that some of the fields will not be required (notably + the sample columns), parsing of these can be skipped by setting max_unpack + appropriately. + Similarly, it is fast to output a BCF line because the columns (kept in + shared.s, indiv.s, etc.) are written directly by bcf_write, whereas a VCF + line must be formatted in vcf_format. + */ +typedef struct { + int32_t rid; // CHROM + int32_t pos; // POS + int32_t rlen; // length of REF + float qual; // QUAL + uint32_t n_info:16, n_allele:16; + uint32_t n_fmt:8, n_sample:24; + kstring_t shared, indiv; + bcf_dec_t d; // lazy evaluation: $d is not generated by bcf_read(), but by explicitly calling bcf_unpack() + int max_unpack; // Set to BCF_UN_STR, BCF_UN_FLT, or BCF_UN_INFO to boost performance of vcf_parse when some of the fields won't be needed + int unpacked; // remember what has been unpacked to allow calling bcf_unpack() repeatedly without redoing the work + int unpack_size[3]; // the original block size of ID, REF+ALT and FILTER + int errcode; // one of BCF_ERR_* codes +} bcf1_t; + +/******* + * API * + *******/ + +#ifdef __cplusplus +extern "C" { +#endif + + /*********************************************************************** + * BCF and VCF I/O + * + * A note about naming conventions: htslib internally represents VCF + * records as bcf1_t data structures, therefore most functions are + * prefixed with bcf_. There are a few exceptions where the functions must + * be aware of both BCF and VCF worlds, such as bcf_parse vs vcf_parse. In + * these cases, functions prefixed with bcf_ are more general and work + * with both BCF and VCF. + * + ***********************************************************************/ + + /** These macros are defined only for consistency with other parts of htslib */ + #define bcf_init1() bcf_init() + #define bcf_read1(fp,h,v) bcf_read((fp),(h),(v)) + #define vcf_read1(fp,h,v) vcf_read((fp),(h),(v)) + #define bcf_write1(fp,h,v) bcf_write((fp),(h),(v)) + #define vcf_write1(fp,h,v) vcf_write((fp),(h),(v)) + #define bcf_destroy1(v) bcf_destroy(v) + #define vcf_parse1(s,h,v) vcf_parse((s),(h),(v)) + #define bcf_clear1(v) bcf_clear(v) + #define vcf_format1(h,v,s) vcf_format((h),(v),(s)) + + /** + * bcf_hdr_init() - create an empty BCF header. + * @param mode "r" or "w" + * + * When opened for writing, the mandatory fileFormat and + * FILTER=PASS lines are added automatically. + */ + bcf_hdr_t *bcf_hdr_init(const char *mode); + + /** Destroy a BCF header struct */ + void bcf_hdr_destroy(bcf_hdr_t *h); + + /** Initialize a bcf1_t object; equivalent to calloc(1, sizeof(bcf1_t)) */ + bcf1_t *bcf_init(void); + + /** Deallocate a bcf1_t object */ + void bcf_destroy(bcf1_t *v); + + /** + * Same as bcf_destroy() but frees only the memory allocated by bcf1_t, + * not the bcf1_t object itself. + */ + void bcf_empty(bcf1_t *v); + + /** + * Make the bcf1_t object ready for next read. Intended mostly for + * internal use, the user should rarely need to call this function + * directly. + */ + void bcf_clear(bcf1_t *v); + + + /** bcf_open and vcf_open mode: please see hts_open() in hts.h */ + typedef htsFile vcfFile; + #define bcf_open(fn, mode) hts_open((fn), (mode)) + #define vcf_open(fn, mode) hts_open((fn), (mode)) + #define bcf_close(fp) hts_close(fp) + #define vcf_close(fp) hts_close(fp) + + /** Reads VCF or BCF header */ + bcf_hdr_t *bcf_hdr_read(htsFile *fp); + + /** + * bcf_hdr_set_samples() - for more efficient VCF parsing when only one/few samples are needed + * @samples: samples to include or exclude from file or as a comma-separated string. + * LIST|FILE .. select samples in list/file + * ^LIST|FILE .. exclude samples from list/file + * - .. include all samples + * NULL .. exclude all samples + * @is_file: @samples is a file (1) or a comma-separated list (1) + * + * The bottleneck of VCF reading is parsing of genotype fields. If the + * reader knows in advance that only subset of samples is needed (possibly + * no samples at all), the performance of bcf_read() can be significantly + * improved by calling bcf_hdr_set_samples after bcf_hdr_read(). + * The function bcf_read() will subset the VCF/BCF records automatically + * with the notable exception when reading records via bcf_itr_next(). + * In this case, bcf_subset_format() must be called explicitly, because + * bcf_readrec() does not see the header. + * + * Returns 0 on success, -1 on error or a positive integer if the list + * contains samples not present in the VCF header. In such a case, the + * return value is the index of the offending sample. + */ + int bcf_hdr_set_samples(bcf_hdr_t *hdr, const char *samples, int is_file); + int bcf_subset_format(const bcf_hdr_t *hdr, bcf1_t *rec); + + + /** Writes VCF or BCF header */ + int bcf_hdr_write(htsFile *fp, bcf_hdr_t *h); + + /** Parse VCF line contained in kstring and populate the bcf1_t struct */ + int vcf_parse(kstring_t *s, const bcf_hdr_t *h, bcf1_t *v); + + /** The opposite of vcf_parse. It should rarely be called directly, see vcf_write */ + int vcf_format(const bcf_hdr_t *h, const bcf1_t *v, kstring_t *s); + + /** + * bcf_read() - read next VCF or BCF record + * + * Returns -1 on critical errors, 0 otherwise. On errors which are not + * critical for reading, such as missing header definitions, v->errcode is + * set to one of BCF_ERR* code and must be checked before calling + * vcf_write(). + */ + int bcf_read(htsFile *fp, const bcf_hdr_t *h, bcf1_t *v); + + /** + * bcf_unpack() - unpack/decode a BCF record (fills the bcf1_t::d field) + * + * Note that bcf_unpack() must be called even when reading VCF. It is safe + * to call the function repeatedly, it will not unpack the same field + * twice. + */ + #define BCF_UN_STR 1 // up to ALT inclusive + #define BCF_UN_FLT 2 // up to FILTER + #define BCF_UN_INFO 4 // up to INFO + #define BCF_UN_SHR (BCF_UN_STR|BCF_UN_FLT|BCF_UN_INFO) // all shared information + #define BCF_UN_FMT 8 // unpack format and each sample + #define BCF_UN_IND BCF_UN_FMT // a synonymo of BCF_UN_FMT + #define BCF_UN_ALL (BCF_UN_SHR|BCF_UN_FMT) // everything + int bcf_unpack(bcf1_t *b, int which); + + /* + * bcf_dup() - create a copy of BCF record. + * + * Note that bcf_unpack() must be called on the returned copy as if it was + * obtained from bcf_read(). Also note that bcf_dup() calls bcf_sync1(src) + * internally to reflect any changes made by bcf_update_* functions. + */ + bcf1_t *bcf_dup(bcf1_t *src); + bcf1_t *bcf_copy(bcf1_t *dst, bcf1_t *src); + + /** + * bcf_write() - write one VCF or BCF record. The type is determined at the open() call. + */ + int bcf_write(htsFile *fp, const bcf_hdr_t *h, bcf1_t *v); + + /** + * The following functions work only with VCFs and should rarely be called + * directly. Usually one wants to use their bcf_* alternatives, which work + * transparently with both VCFs and BCFs. + */ + bcf_hdr_t *vcf_hdr_read(htsFile *fp); + int vcf_hdr_write(htsFile *fp, const bcf_hdr_t *h); + int vcf_read(htsFile *fp, const bcf_hdr_t *h, bcf1_t *v); + int vcf_write(htsFile *fp, const bcf_hdr_t *h, bcf1_t *v); + + /** Helper function for the bcf_itr_next() macro; internal use, ignore it */ + int bcf_readrec(BGZF *fp, void *null, void *v, int *tid, int *beg, int *end); + + + + /************************************************************************** + * Header querying and manipulation routines + **************************************************************************/ + + /** Create a new header using the supplied template */ + bcf_hdr_t *bcf_hdr_dup(const bcf_hdr_t *hdr); + /** + * Copy header lines from src to dst if not already present in dst. See also bcf_translate(). + * Returns 0 on success or sets a bit on error: + * 1 .. conflicting definitions of tag length + * // todo + */ + int bcf_hdr_combine(bcf_hdr_t *dst, const bcf_hdr_t *src); + + /** + * bcf_hdr_add_sample() - add a new sample. + * @param sample: sample name to be added + */ + int bcf_hdr_add_sample(bcf_hdr_t *hdr, const char *sample); + + /** Read VCF header from a file and update the header */ + int bcf_hdr_set(bcf_hdr_t *hdr, const char *fname); + + /** Returns formatted header (newly allocated string) and its length, + * excluding the terminating \0. If is_bcf parameter is unset, IDX + * fields are discarded. + */ + char *bcf_hdr_fmt_text(const bcf_hdr_t *hdr, int is_bcf, int *len); + + /** Append new VCF header line, returns 0 on success */ + int bcf_hdr_append(bcf_hdr_t *h, const char *line); + int bcf_hdr_printf(bcf_hdr_t *h, const char *format, ...); + + /** VCF version, e.g. VCFv4.2 */ + const char *bcf_hdr_get_version(const bcf_hdr_t *hdr); + void bcf_hdr_set_version(bcf_hdr_t *hdr, const char *version); + + /** + * bcf_hdr_remove() - remove VCF header tag + * @param type: one of BCF_HL_* + * @param key: tag name + */ + void bcf_hdr_remove(bcf_hdr_t *h, int type, const char *key); + + /** + * bcf_hdr_subset() - creates a new copy of the header removing unwanted samples + * @param n: number of samples to keep + * @param samples: names of the samples to keep + * @param imap: mapping from index in @samples to the sample index in the original file + * + * Sample names not present in h0 are ignored. The number of unmatched samples can be checked + * by comparing n and bcf_hdr_nsamples(out_hdr). + * This function can be used to reorder samples. + * See also bcf_subset() which subsets individual records. + */ + bcf_hdr_t *bcf_hdr_subset(const bcf_hdr_t *h0, int n, char *const* samples, int *imap); + + /** Creates a list of sequence names. It is up to the caller to free the list (but not the sequence names) */ + const char **bcf_hdr_seqnames(const bcf_hdr_t *h, int *nseqs); + + /** Get number of samples */ + #define bcf_hdr_nsamples(hdr) (hdr)->n[BCF_DT_SAMPLE] + + + /** The following functions are for internal use and should rarely be called directly */ + int bcf_hdr_parse(bcf_hdr_t *hdr, char *htxt); + int bcf_hdr_sync(bcf_hdr_t *h); + bcf_hrec_t *bcf_hdr_parse_line(const bcf_hdr_t *h, const char *line, int *len); + void bcf_hrec_format(const bcf_hrec_t *hrec, kstring_t *str); + int bcf_hdr_add_hrec(bcf_hdr_t *hdr, bcf_hrec_t *hrec); + /** + * bcf_hdr_get_hrec() - get header line info + * @param type: one of the BCF_HL_* types: FLT,INFO,FMT,CTG,STR,GEN + * @param key: the header key for generic lines (e.g. "fileformat"), any field + * for structured lines, typically "ID". + * @param value: the value which pairs with key. Can be be NULL for BCF_HL_GEN + * @param str_class: the class of BCF_HL_STR line (e.g. "ALT" or "SAMPLE"), otherwise NULL + */ + bcf_hrec_t *bcf_hdr_get_hrec(const bcf_hdr_t *hdr, int type, const char *key, const char *value, const char *str_class); + bcf_hrec_t *bcf_hrec_dup(bcf_hrec_t *hrec); + void bcf_hrec_add_key(bcf_hrec_t *hrec, const char *str, int len); + void bcf_hrec_set_val(bcf_hrec_t *hrec, int i, const char *str, int len, int is_quoted); + int bcf_hrec_find_key(bcf_hrec_t *hrec, const char *key); + void hrec_add_idx(bcf_hrec_t *hrec, int idx); + void bcf_hrec_destroy(bcf_hrec_t *hrec); + + + + /************************************************************************** + * Individual record querying and manipulation routines + **************************************************************************/ + + /** See the description of bcf_hdr_subset() */ + int bcf_subset(const bcf_hdr_t *h, bcf1_t *v, int n, int *imap); + + /** + * bcf_translate() - translate tags ids to be consistent with different header. This function + * is useful when lines from multiple VCF need to be combined. + * @dst_hdr: the destination header, to be used in bcf_write(), see also bcf_hdr_combine() + * @src_hdr: the source header, used in bcf_read() + * @src_line: line obtained by bcf_read() + */ + int bcf_translate(const bcf_hdr_t *dst_hdr, bcf_hdr_t *src_hdr, bcf1_t *src_line); + + /** + * bcf_get_variant_type[s]() - returns one of VCF_REF, VCF_SNP, etc + */ + int bcf_get_variant_types(bcf1_t *rec); + int bcf_get_variant_type(bcf1_t *rec, int ith_allele); + int bcf_is_snp(bcf1_t *v); + + /** + * bcf_update_filter() - sets the FILTER column + * @flt_ids: The filter IDs to set, numeric IDs returned by bcf_id2int(hdr, BCF_DT_ID, "PASS") + * @n: Number of filters. If n==0, all filters are removed + */ + int bcf_update_filter(const bcf_hdr_t *hdr, bcf1_t *line, int *flt_ids, int n); + /** + * bcf_add_filter() - adds to the FILTER column + * @flt_id: filter ID to add, numeric ID returned by bcf_id2int(hdr, BCF_DT_ID, "PASS") + * + * If flt_id is PASS, all existing filters are removed first. If other than PASS, existing PASS is removed. + */ + int bcf_add_filter(const bcf_hdr_t *hdr, bcf1_t *line, int flt_id); + /** + * bcf_remove_filter() - removes from the FILTER column + * @flt_id: filter ID to remove, numeric ID returned by bcf_id2int(hdr, BCF_DT_ID, "PASS") + * @pass: when set to 1 and no filters are present, set to PASS + */ + int bcf_remove_filter(const bcf_hdr_t *hdr, bcf1_t *line, int flt_id, int pass); + /** + * Returns 1 if present, 0 if absent, or -1 if filter does not exist. "PASS" and "." can be used interchangeably. + */ + int bcf_has_filter(const bcf_hdr_t *hdr, bcf1_t *line, char *filter); + /** + * bcf_update_alleles() and bcf_update_alleles_str() - update REF and ALLT column + * @alleles: Array of alleles + * @nals: Number of alleles + * @alleles_string: Comma-separated alleles, starting with the REF allele + * + * Not that in order for indexing to work correctly in presence of INFO/END tag, + * the length of reference allele (line->rlen) must be set explicitly by the caller, + * or otherwise, if rlen is zero, strlen(line->d.allele[0]) is used to set the length + * on bcf_write(). + */ + int bcf_update_alleles(const bcf_hdr_t *hdr, bcf1_t *line, const char **alleles, int nals); + int bcf_update_alleles_str(const bcf_hdr_t *hdr, bcf1_t *line, const char *alleles_string); + int bcf_update_id(const bcf_hdr_t *hdr, bcf1_t *line, const char *id); + + /* + * bcf_update_info_*() - functions for updating INFO fields + * @hdr: the BCF header + * @line: VCF line to be edited + * @key: the INFO tag to be updated + * @values: pointer to the array of values. Pass NULL to remove the tag. + * @n: number of values in the array. When set to 0, the INFO tag is removed + * + * The @string in bcf_update_info_flag() is optional, @n indicates whether + * the flag is set or removed. + * + * Returns 0 on success or negative value on error. + */ + #define bcf_update_info_int32(hdr,line,key,values,n) bcf_update_info((hdr),(line),(key),(values),(n),BCF_HT_INT) + #define bcf_update_info_float(hdr,line,key,values,n) bcf_update_info((hdr),(line),(key),(values),(n),BCF_HT_REAL) + #define bcf_update_info_flag(hdr,line,key,string,n) bcf_update_info((hdr),(line),(key),(string),(n),BCF_HT_FLAG) + #define bcf_update_info_string(hdr,line,key,string) bcf_update_info((hdr),(line),(key),(string),1,BCF_HT_STR) + int bcf_update_info(const bcf_hdr_t *hdr, bcf1_t *line, const char *key, const void *values, int n, int type); + + /* + * bcf_update_format_*() - functions for updating FORMAT fields + * @values: pointer to the array of values, the same number of elements + * is expected for each sample. Missing values must be padded + * with bcf_*_missing or bcf_*_vector_end values. + * @n: number of values in the array. If n==0, existing tag is removed. + * + * The function bcf_update_format_string() is a higher-level (slower) variant of + * bcf_update_format_char(). The former accepts array of \0-terminated strings + * whereas the latter requires that the strings are collapsed into a single array + * of fixed-length strings. In case of strings with variable length, shorter strings + * can be \0-padded. Note that the collapsed strings passed to bcf_update_format_char() + * are not \0-terminated. + * + * Returns 0 on success or negative value on error. + */ + #define bcf_update_format_int32(hdr,line,key,values,n) bcf_update_format((hdr),(line),(key),(values),(n),BCF_HT_INT) + #define bcf_update_format_float(hdr,line,key,values,n) bcf_update_format((hdr),(line),(key),(values),(n),BCF_HT_REAL) + #define bcf_update_format_char(hdr,line,key,values,n) bcf_update_format((hdr),(line),(key),(values),(n),BCF_HT_STR) + #define bcf_update_genotypes(hdr,line,gts,n) bcf_update_format((hdr),(line),"GT",(gts),(n),BCF_HT_INT) // See bcf_gt_ macros below + int bcf_update_format_string(const bcf_hdr_t *hdr, bcf1_t *line, const char *key, const char **values, int n); + int bcf_update_format(const bcf_hdr_t *hdr, bcf1_t *line, const char *key, const void *values, int n, int type); + + // Macros for setting genotypes correctly, for use with bcf_update_genotypes only; idx corresponds + // to VCF's GT (1-based index to ALT or 0 for the reference allele) and val is the opposite, obtained + // from bcf_get_genotypes() below. + #define bcf_gt_phased(idx) ((idx+1)<<1|1) + #define bcf_gt_unphased(idx) ((idx+1)<<1) + #define bcf_gt_missing 0 + #define bcf_gt_is_missing(val) ((val)>>1 ? 0 : 1) + #define bcf_gt_is_phased(idx) ((idx)&1) + #define bcf_gt_allele(val) (((val)>>1)-1) + + /** Conversion between alleles indexes to Number=G genotype index (assuming diploid, all 0-based) */ + #define bcf_alleles2gt(a,b) ((a)>(b)?((a)*((a)+1)/2+(b)):((b)*((b)+1)/2+(a))) + static inline void bcf_gt2alleles(int igt, int *a, int *b) + { + int k = 0, dk = 1; + while ( k<igt ) { dk++; k += dk; } + *b = dk - 1; *a = igt - k + *b; + } + + /** + * bcf_get_fmt() - returns pointer to FORMAT's field data + * @header: for access to BCF_DT_ID dictionary + * @line: VCF line obtained from vcf_parse1 + * @fmt: one of GT,PL,... + * + * Returns bcf_fmt_t* if the call succeeded, or returns NULL when the field + * is not available. + */ + bcf_fmt_t *bcf_get_fmt(const bcf_hdr_t *hdr, bcf1_t *line, const char *key); + bcf_info_t *bcf_get_info(const bcf_hdr_t *hdr, bcf1_t *line, const char *key); + + /** + * bcf_get_*_id() - returns pointer to FORMAT/INFO field data given the header index instead of the string ID + * @line: VCF line obtained from vcf_parse1 + * @id: The header index for the tag, obtained from bcf_hdr_id2int() + * + * Returns bcf_fmt_t* / bcf_info_t*. These functions do not check if the index is valid + * as their goal is to avoid the header lookup. + */ + bcf_fmt_t *bcf_get_fmt_id(bcf1_t *line, const int id); + bcf_info_t *bcf_get_info_id(bcf1_t *line, const int id); + + /** + * bcf_get_info_*() - get INFO values, integers or floats + * @hdr: BCF header + * @line: BCF record + * @tag: INFO tag to retrieve + * @dst: *dst is pointer to a memory location, can point to NULL + * @ndst: pointer to the size of allocated memory + * + * Returns negative value on error or the number of written values on + * success. bcf_get_info_string() returns on success the number of + * characters written excluding the null-terminating byte. bcf_get_info_flag() + * returns 1 when flag is set or 0 if not. + * + * List of return codes: + * -1 .. no such INFO tag defined in the header + * -2 .. clash between types defined in the header and encountered in the VCF record + * -3 .. tag is not present in the VCF record + */ + #define bcf_get_info_int32(hdr,line,tag,dst,ndst) bcf_get_info_values(hdr,line,tag,(void**)(dst),ndst,BCF_HT_INT) + #define bcf_get_info_float(hdr,line,tag,dst,ndst) bcf_get_info_values(hdr,line,tag,(void**)(dst),ndst,BCF_HT_REAL) + #define bcf_get_info_string(hdr,line,tag,dst,ndst) bcf_get_info_values(hdr,line,tag,(void**)(dst),ndst,BCF_HT_STR) + #define bcf_get_info_flag(hdr,line,tag,dst,ndst) bcf_get_info_values(hdr,line,tag,(void**)(dst),ndst,BCF_HT_FLAG) + int bcf_get_info_values(const bcf_hdr_t *hdr, bcf1_t *line, const char *tag, void **dst, int *ndst, int type); + + /** + * bcf_get_format_*() - same as bcf_get_info*() above + * + * The function bcf_get_format_string() is a higher-level (slower) variant of bcf_get_format_char(). + * see the description of bcf_update_format_string() and bcf_update_format_char() above. + * Unlike other bcf_get_format__*() functions, bcf_get_format_string() allocates two arrays: + * a single block of \0-terminated strings collapsed into a single array and an array of pointers + * to these strings. Both arrays must be cleaned by the user. + * + * Returns negative value on error or the number of written values on success. + * + * Example: + * int ndst = 0; char **dst = NULL; + * if ( bcf_get_format_string(hdr, line, "XX", &dst, &ndst) > 0 ) + * for (i=0; i<bcf_hdr_nsamples(hdr); i++) printf("%s\n", dst[i]); + * free(dst[0]); free(dst); + * + * Example: + * int ngt, *gt_arr = NULL, ngt_arr = 0; + * ngt = bcf_get_genotypes(hdr, line, >_arr, &ngt_arr); + */ + #define bcf_get_format_int32(hdr,line,tag,dst,ndst) bcf_get_format_values(hdr,line,tag,(void**)(dst),ndst,BCF_HT_INT) + #define bcf_get_format_float(hdr,line,tag,dst,ndst) bcf_get_format_values(hdr,line,tag,(void**)(dst),ndst,BCF_HT_REAL) + #define bcf_get_format_char(hdr,line,tag,dst,ndst) bcf_get_format_values(hdr,line,tag,(void**)(dst),ndst,BCF_HT_STR) + #define bcf_get_genotypes(hdr,line,dst,ndst) bcf_get_format_values(hdr,line,"GT",(void**)(dst),ndst,BCF_HT_INT) + int bcf_get_format_string(const bcf_hdr_t *hdr, bcf1_t *line, const char *tag, char ***dst, int *ndst); + int bcf_get_format_values(const bcf_hdr_t *hdr, bcf1_t *line, const char *tag, void **dst, int *ndst, int type); + + + + /************************************************************************** + * Helper functions + **************************************************************************/ + + /** + * bcf_hdr_id2int() - Translates string into numeric ID + * bcf_hdr_int2id() - Translates numeric ID into string + * @type: one of BCF_DT_ID, BCF_DT_CTG, BCF_DT_SAMPLE + * @id: tag name, such as: PL, DP, GT, etc. + * + * Returns -1 if string is not in dictionary, otherwise numeric ID which identifies + * fields in BCF records. + */ + int bcf_hdr_id2int(const bcf_hdr_t *hdr, int type, const char *id); + #define bcf_hdr_int2id(hdr,type,int_id) ((hdr)->id[type][int_id].key) + + /** + * bcf_hdr_name2id() - Translates sequence names (chromosomes) into numeric ID + * bcf_hdr_id2name() - Translates numeric ID to sequence name + */ + static inline int bcf_hdr_name2id(const bcf_hdr_t *hdr, const char *id) { return bcf_hdr_id2int(hdr, BCF_DT_CTG, id); } + static inline const char *bcf_hdr_id2name(const bcf_hdr_t *hdr, int rid) { return hdr->id[BCF_DT_CTG][rid].key; } + static inline const char *bcf_seqname(const bcf_hdr_t *hdr, bcf1_t *rec) { return hdr->id[BCF_DT_CTG][rec->rid].key; } + + /** + * bcf_hdr_id2*() - Macros for accessing bcf_idinfo_t + * @type: one of BCF_HL_FLT, BCF_HL_INFO, BCF_HL_FMT + * @int_id: return value of bcf_id2int, must be >=0 + * + * The returned values are: + * bcf_hdr_id2length .. whether the number of values is fixed or variable, one of BCF_VL_* + * bcf_hdr_id2number .. the number of values, 0xfffff for variable length fields + * bcf_hdr_id2type .. the field type, one of BCF_HT_* + * bcf_hdr_id2coltype .. the column type, one of BCF_HL_* + * + * Notes: Prior to using the macros, the presence of the info should be + * tested with bcf_hdr_idinfo_exists(). + */ + #define bcf_hdr_id2length(hdr,type,int_id) ((hdr)->id[BCF_DT_ID][int_id].val->info[type]>>8 & 0xf) + #define bcf_hdr_id2number(hdr,type,int_id) ((hdr)->id[BCF_DT_ID][int_id].val->info[type]>>12) + #define bcf_hdr_id2type(hdr,type,int_id) ((hdr)->id[BCF_DT_ID][int_id].val->info[type]>>4 & 0xf) + #define bcf_hdr_id2coltype(hdr,type,int_id) ((hdr)->id[BCF_DT_ID][int_id].val->info[type] & 0xf) + #define bcf_hdr_idinfo_exists(hdr,type,int_id) ((int_id<0 || bcf_hdr_id2coltype(hdr,type,int_id)==0xf) ? 0 : 1) + #define bcf_hdr_id2hrec(hdr,dict_type,col_type,int_id) ((hdr)->id[(dict_type)==BCF_DT_CTG?BCF_DT_CTG:BCF_DT_ID][int_id].val->hrec[(dict_type)==BCF_DT_CTG?0:(col_type)]) + + void bcf_fmt_array(kstring_t *s, int n, int type, void *data); + uint8_t *bcf_fmt_sized_array(kstring_t *s, uint8_t *ptr); + + void bcf_enc_vchar(kstring_t *s, int l, const char *a); + void bcf_enc_vint(kstring_t *s, int n, int32_t *a, int wsize); + void bcf_enc_vfloat(kstring_t *s, int n, float *a); + + + /************************************************************************** + * BCF index + * + * Note that these functions work with BCFs only. See synced_bcf_reader.h + * which provides (amongst other things) an API to work transparently with + * both indexed BCFs and VCFs. + **************************************************************************/ + + #define bcf_itr_destroy(iter) hts_itr_destroy(iter) + #define bcf_itr_queryi(idx, tid, beg, end) hts_itr_query((idx), (tid), (beg), (end), bcf_readrec) + #define bcf_itr_querys(idx, hdr, s) hts_itr_querys((idx), (s), (hts_name2id_f)(bcf_hdr_name2id), (hdr), hts_itr_query, bcf_readrec) + #define bcf_itr_next(htsfp, itr, r) hts_itr_next((htsfp)->fp.bgzf, (itr), (r), 0) + #define bcf_index_load(fn) hts_idx_load(fn, HTS_FMT_CSI) + #define bcf_index_seqnames(idx, hdr, nptr) hts_idx_seqnames((idx),(nptr),(hts_id2name_f)(bcf_hdr_id2name),(hdr)) + + int bcf_index_build(const char *fn, int min_shift); + +#ifdef __cplusplus +} +#endif + +/******************* + * Typed value I/O * + *******************/ + +/* + Note that in contrast with BCFv2.1 specification, HTSlib implementation + allows missing values in vectors. For integer types, the values 0x80, + 0x8000, 0x80000000 are interpreted as missing values and 0x81, 0x8001, + 0x80000001 as end-of-vector indicators. Similarly for floats, the value of + 0x7F800001 is interpreted as a missing value and 0x7F800002 as an + end-of-vector indicator. + Note that the end-of-vector byte is not part of the vector. + + This trial BCF version (v2.2) is compatible with the VCF specification and + enables to handle correctly vectors with different ploidy in presence of + missing values. + */ +#define bcf_int8_vector_end (INT8_MIN+1) +#define bcf_int16_vector_end (INT16_MIN+1) +#define bcf_int32_vector_end (INT32_MIN+1) +#define bcf_str_vector_end 0 +#define bcf_int8_missing INT8_MIN +#define bcf_int16_missing INT16_MIN +#define bcf_int32_missing INT32_MIN +#define bcf_str_missing 0x07 +extern uint32_t bcf_float_vector_end; +extern uint32_t bcf_float_missing; +static inline void bcf_float_set(float *ptr, uint32_t value) +{ + union { uint32_t i; float f; } u; + u.i = value; + *ptr = u.f; +} +#define bcf_float_set_vector_end(x) bcf_float_set(&(x),bcf_float_vector_end) +#define bcf_float_set_missing(x) bcf_float_set(&(x),bcf_float_missing) +static inline int bcf_float_is_missing(float f) +{ + union { uint32_t i; float f; } u; + u.f = f; + return u.i==bcf_float_missing ? 1 : 0; +} +static inline int bcf_float_is_vector_end(float f) +{ + union { uint32_t i; float f; } u; + u.f = f; + return u.i==bcf_float_vector_end ? 1 : 0; +} + +static inline void bcf_format_gt(bcf_fmt_t *fmt, int isample, kstring_t *str) +{ + #define BRANCH(type_t, missing, vector_end) { \ + type_t *ptr = (type_t*) (fmt->p + isample*fmt->size); \ + int i; \ + for (i=0; i<fmt->n && ptr[i]!=vector_end; i++) \ + { \ + if ( i ) kputc("/|"[ptr[i]&1], str); \ + if ( !(ptr[i]>>1) ) kputc('.', str); \ + else kputw((ptr[i]>>1) - 1, str); \ + } \ + if (i == 0) kputc('.', str); \ + } + switch (fmt->type) { + case BCF_BT_INT8: BRANCH(int8_t, bcf_int8_missing, bcf_int8_vector_end); break; + case BCF_BT_INT16: BRANCH(int16_t, bcf_int16_missing, bcf_int16_vector_end); break; + case BCF_BT_INT32: BRANCH(int32_t, bcf_int32_missing, bcf_int32_vector_end); break; + default: fprintf(stderr,"FIXME: type %d in bcf_format_gt?\n", fmt->type); abort(); break; + } + #undef BRANCH +} + +static inline void bcf_enc_size(kstring_t *s, int size, int type) +{ + if (size >= 15) { + kputc(15<<4|type, s); + if (size >= 128) { + if (size >= 32768) { + int32_t x = size; + kputc(1<<4|BCF_BT_INT32, s); + kputsn((char*)&x, 4, s); + } else { + int16_t x = size; + kputc(1<<4|BCF_BT_INT16, s); + kputsn((char*)&x, 2, s); + } + } else { + kputc(1<<4|BCF_BT_INT8, s); + kputc(size, s); + } + } else kputc(size<<4|type, s); +} + +static inline int bcf_enc_inttype(long x) +{ + if (x <= INT8_MAX && x > bcf_int8_missing) return BCF_BT_INT8; + if (x <= INT16_MAX && x > bcf_int16_missing) return BCF_BT_INT16; + return BCF_BT_INT32; +} + +static inline void bcf_enc_int1(kstring_t *s, int32_t x) +{ + if (x == bcf_int32_vector_end) { + bcf_enc_size(s, 1, BCF_BT_INT8); + kputc(bcf_int8_vector_end, s); + } else if (x == bcf_int32_missing) { + bcf_enc_size(s, 1, BCF_BT_INT8); + kputc(bcf_int8_missing, s); + } else if (x <= INT8_MAX && x > bcf_int8_missing) { + bcf_enc_size(s, 1, BCF_BT_INT8); + kputc(x, s); + } else if (x <= INT16_MAX && x > bcf_int16_missing) { + int16_t z = x; + bcf_enc_size(s, 1, BCF_BT_INT16); + kputsn((char*)&z, 2, s); + } else { + int32_t z = x; + bcf_enc_size(s, 1, BCF_BT_INT32); + kputsn((char*)&z, 4, s); + } +} + +static inline int32_t bcf_dec_int1(const uint8_t *p, int type, uint8_t **q) +{ + if (type == BCF_BT_INT8) { + *q = (uint8_t*)p + 1; + return *(int8_t*)p; + } else if (type == BCF_BT_INT16) { + *q = (uint8_t*)p + 2; + return *(int16_t*)p; + } else { + *q = (uint8_t*)p + 4; + return *(int32_t*)p; + } +} + +static inline int32_t bcf_dec_typed_int1(const uint8_t *p, uint8_t **q) +{ + return bcf_dec_int1(p + 1, *p&0xf, q); +} + +static inline int32_t bcf_dec_size(const uint8_t *p, uint8_t **q, int *type) +{ + *type = *p & 0xf; + if (*p>>4 != 15) { + *q = (uint8_t*)p + 1; + return *p>>4; + } else return bcf_dec_typed_int1(p + 1, q); +} + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/vcf_sweep.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,39 @@ +/* vcf_sweep.h -- forward/reverse sweep API. + + Copyright (C) 2013 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_VCF_SWEEP_H +#define HTSLIB_VCF_SWEEP_H + +#include "hts.h" +#include "vcf.h" + +typedef struct _bcf_sweep_t bcf_sweep_t; + +bcf_sweep_t *bcf_sweep_init(const char *fname); +void bcf_sweep_destroy(bcf_sweep_t *sw); +bcf_hdr_t *bcf_sweep_hdr(bcf_sweep_t *sw); +bcf1_t *bcf_sweep_fwd(bcf_sweep_t *sw); +bcf1_t *bcf_sweep_bwd(bcf_sweep_t *sw); + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib/vcfutils.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,112 @@ +/* vcfutils.h -- allele-related utility functions. + + Copyright (C) 2012, 2013 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#ifndef HTSLIB_VCFUTILS_H +#define HTSLIB_VCFUTILS_H + +#include "vcf.h" + + +/** + * bcf_trim_alleles() - remove ALT alleles unused in genotype fields + * @header: for access to BCF_DT_ID dictionary + * @line: VCF line obtain from vcf_parse1 + * + * Returns the number of removed alleles on success or negative + * on error: + * -1 .. some allele index is out of bounds + */ +int bcf_trim_alleles(const bcf_hdr_t *header, bcf1_t *line); + + +/** + * bcf_remove_alleles() - remove ALT alleles according to bitmask @mask + * @header: for access to BCF_DT_ID dictionary + * @line: VCF line obtained from vcf_parse1 + * @mask: alleles to remove + */ +void bcf_remove_alleles(const bcf_hdr_t *header, bcf1_t *line, int mask); + + +/** + * bcf_calc_ac() - calculate the number of REF and ALT alleles + * @header: for access to BCF_DT_ID dictionary + * @line: VCF line obtained from vcf_parse1 + * @ac: array of length line->n_allele + * @which: determine if INFO/AN,AC and indv fields be used + * + * Returns 1 if the call succeeded, or 0 if the value could not + * be determined. + * + * The value of @which determines if existing INFO/AC,AN can be + * used (BCF_UN_INFO) and and if indv fields can be splitted + * (BCF_UN_FMT). + */ +int bcf_calc_ac(const bcf_hdr_t *header, bcf1_t *line, int *ac, int which); + + +/** + * bcf_gt_type() - determines type of the genotype + * @fmt_ptr: the GT format field as set for example by set_fmt_ptr + * @isample: sample index (starting from 0) + * @ial: index of the 1st non-reference allele (starting from 1) + * @jal: index of the 2nd non-reference allele (starting from 1) + * + * Returns the type of the genotype (one of GT_HOM_RR, GT_HET_RA, + * GT_HOM_AA, GT_HET_AA, GT_HAPL_R, GT_HAPL_A or GT_UNKN). If $ial + * is not NULL and the genotype has one or more non-reference + * alleles, $ial will be set. In case of GT_HET_AA, $ial is the + * position of the allele which appeared first in ALT. If $jal is + * not null and the genotype is GT_HET_AA, $jal will be set and is + * the position of the second allele in ALT. + */ +#define GT_HOM_RR 0 // note: the actual value of GT_* matters, used in dosage r2 calculation +#define GT_HOM_AA 1 +#define GT_HET_RA 2 +#define GT_HET_AA 3 +#define GT_HAPL_R 4 +#define GT_HAPL_A 5 +#define GT_UNKN 6 +int bcf_gt_type(bcf_fmt_t *fmt_ptr, int isample, int *ial, int *jal); + +static inline int bcf_acgt2int(char c) +{ + if ( (int)c>96 ) c -= 32; + if ( c=='A' ) return 0; + if ( c=='C' ) return 1; + if ( c=='G' ) return 2; + if ( c=='T' ) return 3; + return -1; +} +#define bcf_int2acgt(i) "ACGT"[i] + +/** + * bcf_ij2G() - common task: allele indexes to Number=G index (diploid) + * @i,j: allele indexes, 0-based, i<=j + * + * Returns index to the Number=G diploid array + */ +#define bcf_ij2G(i, j) ((j)*((j)+1)/2+(i)) + +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/htslib_vars.mk Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,39 @@ +# Makefile variables useful for third-party code using htslib's public API. +# +# Copyright (C) 2013-2014 Genome Research Ltd. +# +# Author: John Marshall <jm18@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +# These variables can be used to express dependencies on htslib headers. +# See htslib.mk for details. + +htslib_bgzf_h = $(HTSPREFIX)htslib/bgzf.h +htslib_faidx_h = $(HTSPREFIX)htslib/faidx.h +htslib_hfile_h = $(HTSPREFIX)htslib/hfile.h $(htslib_hts_defs_h) +htslib_hts_h = $(HTSPREFIX)htslib/hts.h +htslib_hts_defs_h = $(HTSPREFIX)htslib/hts_defs.h +htslib_regidx_h = $(HTSPREFIX)htslib/regidx.h +htslib_sam_h = $(HTSPREFIX)htslib/sam.h $(htslib_hts_h) +htslib_synced_bcf_reader_h = $(HTSPREFIX)htslib/synced_bcf_reader.h $(htslib_hts_h) $(htslib_vcf_h) $(htslib_tbx_h) +htslib_tbx_h = $(HTSPREFIX)htslib/tbx.h $(htslib_hts_h) +htslib_vcf_h = $(HTSPREFIX)htslib/vcf.h $(htslib_hts_h) $(HTSPREFIX)htslib/kstring.h +htslib_vcf_sweep_h = $(HTSPREFIX)htslib/vcf_sweep.h $(htslib_hts_h) $(htslib_vcf_h) +htslib_vcfutils_h = $(HTSPREFIX)htslib/vcfutils.h $(htslib_vcf_h)
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/kfunc.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,280 @@ +/* The MIT License + + Copyright (C) 2010, 2013 Genome Research Ltd. + Copyright (C) 2011 Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +#include <math.h> +#include <stdlib.h> +#include "htslib/kfunc.h" + +/* Log gamma function + * \log{\Gamma(z)} + * AS245, 2nd algorithm, http://lib.stat.cmu.edu/apstat/245 + */ +double kf_lgamma(double z) +{ + double x = 0; + x += 0.1659470187408462e-06 / (z+7); + x += 0.9934937113930748e-05 / (z+6); + x -= 0.1385710331296526 / (z+5); + x += 12.50734324009056 / (z+4); + x -= 176.6150291498386 / (z+3); + x += 771.3234287757674 / (z+2); + x -= 1259.139216722289 / (z+1); + x += 676.5203681218835 / z; + x += 0.9999999999995183; + return log(x) - 5.58106146679532777 - z + (z-0.5) * log(z+6.5); +} + +/* complementary error function + * \frac{2}{\sqrt{\pi}} \int_x^{\infty} e^{-t^2} dt + * AS66, 2nd algorithm, http://lib.stat.cmu.edu/apstat/66 + */ +double kf_erfc(double x) +{ + const double p0 = 220.2068679123761; + const double p1 = 221.2135961699311; + const double p2 = 112.0792914978709; + const double p3 = 33.912866078383; + const double p4 = 6.37396220353165; + const double p5 = .7003830644436881; + const double p6 = .03526249659989109; + const double q0 = 440.4137358247522; + const double q1 = 793.8265125199484; + const double q2 = 637.3336333788311; + const double q3 = 296.5642487796737; + const double q4 = 86.78073220294608; + const double q5 = 16.06417757920695; + const double q6 = 1.755667163182642; + const double q7 = .08838834764831844; + double expntl, z, p; + z = fabs(x) * M_SQRT2; + if (z > 37.) return x > 0.? 0. : 2.; + expntl = exp(z * z * - .5); + if (z < 10. / M_SQRT2) // for small z + p = expntl * ((((((p6 * z + p5) * z + p4) * z + p3) * z + p2) * z + p1) * z + p0) + / (((((((q7 * z + q6) * z + q5) * z + q4) * z + q3) * z + q2) * z + q1) * z + q0); + else p = expntl / 2.506628274631001 / (z + 1. / (z + 2. / (z + 3. / (z + 4. / (z + .65))))); + return x > 0.? 2. * p : 2. * (1. - p); +} + +/* The following computes regularized incomplete gamma functions. + * Formulas are taken from Wiki, with additional input from Numerical + * Recipes in C (for modified Lentz's algorithm) and AS245 + * (http://lib.stat.cmu.edu/apstat/245). + * + * A good online calculator is available at: + * + * http://www.danielsoper.com/statcalc/calc23.aspx + * + * It calculates upper incomplete gamma function, which equals + * kf_gammaq(s,z)*tgamma(s). + */ + +#define KF_GAMMA_EPS 1e-14 +#define KF_TINY 1e-290 + +// regularized lower incomplete gamma function, by series expansion +static double _kf_gammap(double s, double z) +{ + double sum, x; + int k; + for (k = 1, sum = x = 1.; k < 100; ++k) { + sum += (x *= z / (s + k)); + if (x / sum < KF_GAMMA_EPS) break; + } + return exp(s * log(z) - z - kf_lgamma(s + 1.) + log(sum)); +} +// regularized upper incomplete gamma function, by continued fraction +static double _kf_gammaq(double s, double z) +{ + int j; + double C, D, f; + f = 1. + z - s; C = f; D = 0.; + // Modified Lentz's algorithm for computing continued fraction + // See Numerical Recipes in C, 2nd edition, section 5.2 + for (j = 1; j < 100; ++j) { + double a = j * (s - j), b = (j<<1) + 1 + z - s, d; + D = b + a * D; + if (D < KF_TINY) D = KF_TINY; + C = b + a / C; + if (C < KF_TINY) C = KF_TINY; + D = 1. / D; + d = C * D; + f *= d; + if (fabs(d - 1.) < KF_GAMMA_EPS) break; + } + return exp(s * log(z) - z - kf_lgamma(s) - log(f)); +} + +double kf_gammap(double s, double z) +{ + return z <= 1. || z < s? _kf_gammap(s, z) : 1. - _kf_gammaq(s, z); +} + +double kf_gammaq(double s, double z) +{ + return z <= 1. || z < s? 1. - _kf_gammap(s, z) : _kf_gammaq(s, z); +} + +/* Regularized incomplete beta function. The method is taken from + * Numerical Recipe in C, 2nd edition, section 6.4. The following web + * page calculates the incomplete beta function, which equals + * kf_betai(a,b,x) * gamma(a) * gamma(b) / gamma(a+b): + * + * http://www.danielsoper.com/statcalc/calc36.aspx + */ +static double kf_betai_aux(double a, double b, double x) +{ + double C, D, f; + int j; + if (x == 0.) return 0.; + if (x == 1.) return 1.; + f = 1.; C = f; D = 0.; + // Modified Lentz's algorithm for computing continued fraction + for (j = 1; j < 200; ++j) { + double aa, d; + int m = j>>1; + aa = (j&1)? -(a + m) * (a + b + m) * x / ((a + 2*m) * (a + 2*m + 1)) + : m * (b - m) * x / ((a + 2*m - 1) * (a + 2*m)); + D = 1. + aa * D; + if (D < KF_TINY) D = KF_TINY; + C = 1. + aa / C; + if (C < KF_TINY) C = KF_TINY; + D = 1. / D; + d = C * D; + f *= d; + if (fabs(d - 1.) < KF_GAMMA_EPS) break; + } + return exp(kf_lgamma(a+b) - kf_lgamma(a) - kf_lgamma(b) + a * log(x) + b * log(1.-x)) / a / f; +} +double kf_betai(double a, double b, double x) +{ + return x < (a + 1.) / (a + b + 2.)? kf_betai_aux(a, b, x) : 1. - kf_betai_aux(b, a, 1. - x); +} + +#ifdef KF_MAIN +#include <stdio.h> +int main(int argc, char *argv[]) +{ + double x = 5.5, y = 3; + double a, b; + printf("erfc(%lg): %lg, %lg\n", x, erfc(x), kf_erfc(x)); + printf("upper-gamma(%lg,%lg): %lg\n", x, y, kf_gammaq(y, x)*tgamma(y)); + a = 2; b = 2; x = 0.5; + printf("incomplete-beta(%lg,%lg,%lg): %lg\n", a, b, x, kf_betai(a, b, x) / exp(kf_lgamma(a+b) - kf_lgamma(a) - kf_lgamma(b))); + return 0; +} +#endif + + +// log\binom{n}{k} +static double lbinom(int n, int k) +{ + if (k == 0 || n == k) return 0; + return lgamma(n+1) - lgamma(k+1) - lgamma(n-k+1); +} + +// n11 n12 | n1_ +// n21 n22 | n2_ +//-----------+---- +// n_1 n_2 | n + +// hypergeometric distribution +static double hypergeo(int n11, int n1_, int n_1, int n) +{ + return exp(lbinom(n1_, n11) + lbinom(n-n1_, n_1-n11) - lbinom(n, n_1)); +} + +typedef struct { + int n11, n1_, n_1, n; + double p; +} hgacc_t; + +// incremental version of hypergenometric distribution +static double hypergeo_acc(int n11, int n1_, int n_1, int n, hgacc_t *aux) +{ + if (n1_ || n_1 || n) { + aux->n11 = n11; aux->n1_ = n1_; aux->n_1 = n_1; aux->n = n; + } else { // then only n11 changed; the rest fixed + if (n11%11 && n11 + aux->n - aux->n1_ - aux->n_1) { + if (n11 == aux->n11 + 1) { // incremental + aux->p *= (double)(aux->n1_ - aux->n11) / n11 + * (aux->n_1 - aux->n11) / (n11 + aux->n - aux->n1_ - aux->n_1); + aux->n11 = n11; + return aux->p; + } + if (n11 == aux->n11 - 1) { // incremental + aux->p *= (double)aux->n11 / (aux->n1_ - n11) + * (aux->n11 + aux->n - aux->n1_ - aux->n_1) / (aux->n_1 - n11); + aux->n11 = n11; + return aux->p; + } + } + aux->n11 = n11; + } + aux->p = hypergeo(aux->n11, aux->n1_, aux->n_1, aux->n); + return aux->p; +} + +double kt_fisher_exact(int n11, int n12, int n21, int n22, double *_left, double *_right, double *two) +{ + int i, j, max, min; + double p, q, left, right; + hgacc_t aux; + int n1_, n_1, n; + + n1_ = n11 + n12; n_1 = n11 + n21; n = n11 + n12 + n21 + n22; // calculate n1_, n_1 and n + max = (n_1 < n1_) ? n_1 : n1_; // max n11, for right tail + min = n1_ + n_1 - n; // not sure why n11-n22 is used instead of min(n_1,n1_) + if (min < 0) min = 0; // min n11, for left tail + *two = *_left = *_right = 1.; + if (min == max) return 1.; // no need to do test + q = hypergeo_acc(n11, n1_, n_1, n, &aux); // the probability of the current table + // left tail + p = hypergeo_acc(min, 0, 0, 0, &aux); + for (left = 0., i = min + 1; p < 0.99999999 * q && i<=max; ++i) // loop until underflow + left += p, p = hypergeo_acc(i, 0, 0, 0, &aux); + --i; + if (p < 1.00000001 * q) left += p; + else --i; + // right tail + p = hypergeo_acc(max, 0, 0, 0, &aux); + for (right = 0., j = max - 1; p < 0.99999999 * q && j>=0; --j) // loop until underflow + right += p, p = hypergeo_acc(j, 0, 0, 0, &aux); + ++j; + if (p < 1.00000001 * q) right += p; + else ++j; + // two-tail + *two = left + right; + if (*two > 1.) *two = 1.; + // adjust left and right + if (abs(i - n11) < abs(j - n11)) right = 1. - left + q; + else left = 1.0 - right + q; + *_left = left; *_right = right; + return q; +} + + +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/knetfile.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,632 @@ +/* The MIT License + + Copyright (c) 2008 by Genome Research Ltd (GRL). + 2010 by Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +/* Probably I will not do socket programming in the next few years and + therefore I decide to heavily annotate this file, for Linux and + Windows as well. -ac */ + +#include <time.h> +#include <stdio.h> +#include <ctype.h> +#include <stdlib.h> +#include <string.h> +#include <errno.h> +#include <unistd.h> +#include <sys/types.h> + +#ifndef _WIN32 +#include <netdb.h> +#include <arpa/inet.h> +#include <sys/socket.h> +#endif + +#include "htslib/knetfile.h" + +/* In winsock.h, the type of a socket is SOCKET, which is: "typedef + * u_int SOCKET". An invalid SOCKET is: "(SOCKET)(~0)", or signed + * integer -1. In knetfile.c, I use "int" for socket type + * throughout. This should be improved to avoid confusion. + * + * In Linux/Mac, recv() and read() do almost the same thing. You can see + * in the header file that netread() is simply an alias of read(). In + * Windows, however, they are different and using recv() is mandatory. + */ + +/* This function tests if the file handler is ready for reading (or + * writing if is_read==0). */ +static int socket_wait(int fd, int is_read) +{ + fd_set fds, *fdr = 0, *fdw = 0; + struct timeval tv; + int ret; + tv.tv_sec = 5; tv.tv_usec = 0; // 5 seconds time out + FD_ZERO(&fds); + FD_SET(fd, &fds); + if (is_read) fdr = &fds; + else fdw = &fds; + ret = select(fd+1, fdr, fdw, 0, &tv); +#ifndef _WIN32 + if (ret == -1) perror("select"); +#else + if (ret == 0) + fprintf(stderr, "select time-out\n"); + else if (ret == SOCKET_ERROR) + fprintf(stderr, "select: %d\n", WSAGetLastError()); +#endif + return ret; +} + +#ifndef _WIN32 +/* This function does not work with Windows due to the lack of + * getaddrinfo() in winsock. It is addapted from an example in "Beej's + * Guide to Network Programming" (http://beej.us/guide/bgnet/). */ +static int socket_connect(const char *host, const char *port) +{ +#define __err_connect(func) do { perror(func); freeaddrinfo(res); return -1; } while (0) + + int ai_err, on = 1, fd; + struct linger lng = { 0, 0 }; + struct addrinfo hints, *res = 0; + memset(&hints, 0, sizeof(struct addrinfo)); + hints.ai_family = AF_UNSPEC; + hints.ai_socktype = SOCK_STREAM; + /* In Unix/Mac, getaddrinfo() is the most convenient way to get + * server information. */ + if ((ai_err = getaddrinfo(host, port, &hints, &res)) != 0) { fprintf(stderr, "can't resolve %s:%s: %s\n", host, port, gai_strerror(ai_err)); return -1; } + if ((fd = socket(res->ai_family, res->ai_socktype, res->ai_protocol)) == -1) __err_connect("socket"); + /* The following two setsockopt() are used by ftplib + * (http://nbpfaus.net/~pfau/ftplib/). I am not sure if they + * necessary. */ + if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, &on, sizeof(on)) == -1) __err_connect("setsockopt"); + if (setsockopt(fd, SOL_SOCKET, SO_LINGER, &lng, sizeof(lng)) == -1) __err_connect("setsockopt"); + if (connect(fd, res->ai_addr, res->ai_addrlen) != 0) __err_connect("connect"); + freeaddrinfo(res); + return fd; +} +#else +/* MinGW's printf has problem with "%lld" */ +char *int64tostr(char *buf, int64_t x) +{ + int cnt; + int i = 0; + do { + buf[i++] = '0' + x % 10; + x /= 10; + } while (x); + buf[i] = 0; + for (cnt = i, i = 0; i < cnt/2; ++i) { + int c = buf[i]; buf[i] = buf[cnt-i-1]; buf[cnt-i-1] = c; + } + return buf; +} + +int64_t strtoint64(const char *buf) +{ + int64_t x; + for (x = 0; *buf != '\0'; ++buf) + x = x * 10 + ((int64_t) *buf - 48); + return x; +} +/* In windows, the first thing is to establish the TCP connection. */ +int knet_win32_init() +{ + WSADATA wsaData; + return WSAStartup(MAKEWORD(2, 2), &wsaData); +} +void knet_win32_destroy() +{ + WSACleanup(); +} +/* A slightly modfied version of the following function also works on + * Mac (and presummably Linux). However, this function is not stable on + * my Mac. It sometimes works fine but sometimes does not. Therefore for + * non-Windows OS, I do not use this one. */ +static SOCKET socket_connect(const char *host, const char *port) +{ +#define __err_connect(func) \ + do { \ + fprintf(stderr, "%s: %d\n", func, WSAGetLastError()); \ + return -1; \ + } while (0) + + int on = 1; + SOCKET fd; + struct linger lng = { 0, 0 }; + struct sockaddr_in server; + struct hostent *hp = 0; + // open socket + if ((fd = socket(AF_INET, SOCK_STREAM, IPPROTO_TCP)) == INVALID_SOCKET) __err_connect("socket"); + if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, (char*)&on, sizeof(on)) == -1) __err_connect("setsockopt"); + if (setsockopt(fd, SOL_SOCKET, SO_LINGER, (char*)&lng, sizeof(lng)) == -1) __err_connect("setsockopt"); + // get host info + if (isalpha(host[0])) hp = gethostbyname(host); + else { + struct in_addr addr; + addr.s_addr = inet_addr(host); + hp = gethostbyaddr((char*)&addr, 4, AF_INET); + } + if (hp == 0) __err_connect("gethost"); + // connect + server.sin_addr.s_addr = *((unsigned long*)hp->h_addr); + server.sin_family= AF_INET; + server.sin_port = htons(atoi(port)); + if (connect(fd, (struct sockaddr*)&server, sizeof(server)) != 0) __err_connect("connect"); + // freehostent(hp); // strangely in MSDN, hp is NOT freed (memory leak?!) + return fd; +} +#endif + +static off_t my_netread(int fd, void *buf, off_t len) +{ + off_t rest = len, curr, l = 0; + /* recv() and read() may not read the required length of data with + * one call. They have to be called repeatedly. */ + while (rest) { + if (socket_wait(fd, 1) <= 0) break; // socket is not ready for reading + curr = netread(fd, (void*)((char*)buf + l), rest); + /* According to the glibc manual, section 13.2, a zero returned + * value indicates end-of-file (EOF), which should mean that + * read() will not return zero if EOF has not been met but data + * are not immediately available. */ + if (curr == 0) break; + l += curr; rest -= curr; + } + return l; +} + +/************************* + * FTP specific routines * + *************************/ + +static int kftp_get_response(knetFile *ftp) +{ +#ifndef _WIN32 + unsigned char c; +#else + char c; +#endif + int n = 0; + char *p; + if (socket_wait(ftp->ctrl_fd, 1) <= 0) return 0; + while (netread(ftp->ctrl_fd, &c, 1)) { // FIXME: this is *VERY BAD* for unbuffered I/O + //fputc(c, stderr); + if (n >= ftp->max_response) { + ftp->max_response = ftp->max_response? ftp->max_response<<1 : 256; + ftp->response = (char*)realloc(ftp->response, ftp->max_response); + } + ftp->response[n++] = c; + if (c == '\n') { + if (n >= 4 && isdigit(ftp->response[0]) && isdigit(ftp->response[1]) && isdigit(ftp->response[2]) + && ftp->response[3] != '-') break; + n = 0; + continue; + } + } + if (n < 2) return -1; + ftp->response[n-2] = 0; + return strtol(ftp->response, &p, 0); +} + +static int kftp_send_cmd(knetFile *ftp, const char *cmd, int is_get) +{ + if (socket_wait(ftp->ctrl_fd, 0) <= 0) return -1; // socket is not ready for writing + int len = strlen(cmd); + if ( netwrite(ftp->ctrl_fd, cmd, len) != len ) return -1; + return is_get? kftp_get_response(ftp) : 0; +} + +static int kftp_pasv_prep(knetFile *ftp) +{ + char *p; + int v[6]; + kftp_send_cmd(ftp, "PASV\r\n", 1); + for (p = ftp->response; *p && *p != '('; ++p); + if (*p != '(') return -1; + ++p; + sscanf(p, "%d,%d,%d,%d,%d,%d", &v[0], &v[1], &v[2], &v[3], &v[4], &v[5]); + memcpy(ftp->pasv_ip, v, 4 * sizeof(int)); + ftp->pasv_port = (v[4]<<8&0xff00) + v[5]; + return 0; +} + + +static int kftp_pasv_connect(knetFile *ftp) +{ + char host[80], port[10]; + if (ftp->pasv_port == 0) { + fprintf(stderr, "[kftp_pasv_connect] kftp_pasv_prep() is not called before hand.\n"); + return -1; + } + sprintf(host, "%d.%d.%d.%d", ftp->pasv_ip[0], ftp->pasv_ip[1], ftp->pasv_ip[2], ftp->pasv_ip[3]); + sprintf(port, "%d", ftp->pasv_port); + ftp->fd = socket_connect(host, port); + if (ftp->fd == -1) return -1; + return 0; +} + +int kftp_connect(knetFile *ftp) +{ + ftp->ctrl_fd = socket_connect(ftp->host, ftp->port); + if (ftp->ctrl_fd == -1) return -1; + kftp_get_response(ftp); + kftp_send_cmd(ftp, "USER anonymous\r\n", 1); + kftp_send_cmd(ftp, "PASS kftp@\r\n", 1); + kftp_send_cmd(ftp, "TYPE I\r\n", 1); + return 0; +} + +int kftp_reconnect(knetFile *ftp) +{ + if (ftp->ctrl_fd != -1) { + netclose(ftp->ctrl_fd); + ftp->ctrl_fd = -1; + } + netclose(ftp->fd); + ftp->fd = -1; + return kftp_connect(ftp); +} + +// initialize ->type, ->host, ->retr and ->size +knetFile *kftp_parse_url(const char *fn, const char *mode) +{ + knetFile *fp; + char *p; + int l; + if (strstr(fn, "ftp://") != fn) return 0; + for (p = (char*)fn + 6; *p && *p != '/'; ++p); + if (*p != '/') return 0; + l = p - fn - 6; + fp = (knetFile*)calloc(1, sizeof(knetFile)); + fp->type = KNF_TYPE_FTP; + fp->fd = -1; + /* the Linux/Mac version of socket_connect() also recognizes a port + * like "ftp", but the Windows version does not. */ + fp->port = strdup("21"); + fp->host = (char*)calloc(l + 1, 1); + if (strchr(mode, 'c')) fp->no_reconnect = 1; + strncpy(fp->host, fn + 6, l); + fp->retr = (char*)calloc(strlen(p) + 8, 1); + sprintf(fp->retr, "RETR %s\r\n", p); + fp->size_cmd = (char*)calloc(strlen(p) + 8, 1); + sprintf(fp->size_cmd, "SIZE %s\r\n", p); + fp->seek_offset = 0; + return fp; +} +// place ->fd at offset off +int kftp_connect_file(knetFile *fp) +{ + int ret; + long long file_size; + if (fp->fd != -1) { + netclose(fp->fd); + if (fp->no_reconnect) kftp_get_response(fp); + } + kftp_pasv_prep(fp); + kftp_send_cmd(fp, fp->size_cmd, 1); +#ifndef _WIN32 + // If the file does not exist, the response will be "550 Could not get file + // size". Be silent on failure, hts_idx_load can be trying the existence of .csi or .tbi. + if ( sscanf(fp->response,"%*d %lld", &file_size) != 1 ) return -1; +#else + const char *p = fp->response; + while (*p != ' ') ++p; + while (*p < '0' || *p > '9') ++p; + file_size = strtoint64(p); +#endif + fp->file_size = file_size; + if (fp->offset>=0) { + char tmp[32]; +#ifndef _WIN32 + sprintf(tmp, "REST %lld\r\n", (long long)fp->offset); +#else + strcpy(tmp, "REST "); + int64tostr(tmp + 5, fp->offset); + strcat(tmp, "\r\n"); +#endif + kftp_send_cmd(fp, tmp, 1); + } + kftp_send_cmd(fp, fp->retr, 0); + kftp_pasv_connect(fp); + ret = kftp_get_response(fp); + if (ret != 150) { + fprintf(stderr, "[kftp_connect_file] %s\n", fp->response); + netclose(fp->fd); + fp->fd = -1; + return -1; + } + fp->is_ready = 1; + return 0; +} + + +/************************** + * HTTP specific routines * + **************************/ + +knetFile *khttp_parse_url(const char *fn, const char *mode) +{ + knetFile *fp; + char *p, *proxy, *q; + int l; + if (strstr(fn, "http://") != fn) return 0; + // set ->http_host + for (p = (char*)fn + 7; *p && *p != '/'; ++p); + l = p - fn - 7; + fp = (knetFile*)calloc(1, sizeof(knetFile)); + fp->http_host = (char*)calloc(l + 1, 1); + strncpy(fp->http_host, fn + 7, l); + fp->http_host[l] = 0; + for (q = fp->http_host; *q && *q != ':'; ++q); + if (*q == ':') *q++ = 0; + // get http_proxy + proxy = getenv("http_proxy"); + // set ->host, ->port and ->path + if (proxy == 0) { + fp->host = strdup(fp->http_host); // when there is no proxy, server name is identical to http_host name. + fp->port = strdup(*q? q : "80"); + fp->path = strdup(*p? p : "/"); + } else { + fp->host = (strstr(proxy, "http://") == proxy)? strdup(proxy + 7) : strdup(proxy); + for (q = fp->host; *q && *q != ':'; ++q); + if (*q == ':') *q++ = 0; + fp->port = strdup(*q? q : "80"); + fp->path = strdup(fn); + } + fp->type = KNF_TYPE_HTTP; + fp->ctrl_fd = fp->fd = -1; + fp->seek_offset = 0; + return fp; +} + +int khttp_connect_file(knetFile *fp) +{ + int ret, l = 0; + char *buf, *p; + if (fp->fd != -1) netclose(fp->fd); + fp->fd = socket_connect(fp->host, fp->port); + buf = (char*)calloc(0x10000, 1); // FIXME: I am lazy... But in principle, 64KB should be large enough. + l += sprintf(buf + l, "GET %s HTTP/1.0\r\nHost: %s\r\n", fp->path, fp->http_host); + l += sprintf(buf + l, "Range: bytes=%lld-\r\n", (long long)fp->offset); + l += sprintf(buf + l, "\r\n"); + if ( netwrite(fp->fd, buf, l) != l ) { free(buf); return -1; } + l = 0; + while (netread(fp->fd, buf + l, 1)) { // read HTTP header; FIXME: bad efficiency + if (buf[l] == '\n' && l >= 3) + if (strncmp(buf + l - 3, "\r\n\r\n", 4) == 0) break; + ++l; + } + buf[l] = 0; + if (l < 14) { // prematured header + free(buf); + netclose(fp->fd); + fp->fd = -1; + return -1; + } + ret = strtol(buf + 8, &p, 0); // HTTP return code + if (ret == 200 && fp->offset>0) { // 200 (complete result); then skip beginning of the file + off_t rest = fp->offset; + while (rest) { + off_t l = rest < 0x10000? rest : 0x10000; + rest -= my_netread(fp->fd, buf, l); + } + } else if (ret != 206 && ret != 200) { + // failed to open file + free(buf); + netclose(fp->fd); + switch (ret) { + case 401: errno = EPERM; break; + case 403: errno = EACCES; break; + case 404: errno = ENOENT; break; + case 407: errno = EPERM; break; + case 408: errno = ETIMEDOUT; break; + case 410: errno = ENOENT; break; + case 503: errno = EAGAIN; break; + case 504: errno = ETIMEDOUT; break; + default: errno = (ret >= 400 && ret < 500)? EINVAL : EIO; break; + } + fp->fd = -1; + return -1; + } + free(buf); + fp->is_ready = 1; + return 0; +} + +/******************** + * Generic routines * + ********************/ + +knetFile *knet_open(const char *fn, const char *mode) +{ + knetFile *fp = 0; + if (mode[0] != 'r') { + fprintf(stderr, "[kftp_open] only mode \"r\" is supported.\n"); + return 0; + } + if (strstr(fn, "ftp://") == fn) { + fp = kftp_parse_url(fn, mode); + if (fp == 0) return 0; + if (kftp_connect(fp) == -1) { + knet_close(fp); + return 0; + } + kftp_connect_file(fp); + } else if (strstr(fn, "http://") == fn) { + fp = khttp_parse_url(fn, mode); + if (fp == 0) return 0; + khttp_connect_file(fp); + } else { // local file +#ifdef _WIN32 + /* In windows, O_BINARY is necessary. In Linux/Mac, O_BINARY may + * be undefined on some systems, although it is defined on my + * Mac and the Linux I have tested on. */ + int fd = open(fn, O_RDONLY | O_BINARY); +#else + int fd = open(fn, O_RDONLY); +#endif + if (fd == -1) { + perror("open"); + return 0; + } + fp = (knetFile*)calloc(1, sizeof(knetFile)); + fp->type = KNF_TYPE_LOCAL; + fp->fd = fd; + fp->ctrl_fd = -1; + } + if (fp && fp->fd == -1) { + knet_close(fp); + return 0; + } + return fp; +} + +knetFile *knet_dopen(int fd, const char *mode) +{ + knetFile *fp = (knetFile*)calloc(1, sizeof(knetFile)); + fp->type = KNF_TYPE_LOCAL; + fp->fd = fd; + return fp; +} + +ssize_t knet_read(knetFile *fp, void *buf, size_t len) +{ + off_t l = 0; + if (fp->fd == -1) return 0; + if (fp->type == KNF_TYPE_FTP) { + if (fp->is_ready == 0) { + if (!fp->no_reconnect) kftp_reconnect(fp); + kftp_connect_file(fp); + } + } else if (fp->type == KNF_TYPE_HTTP) { + if (fp->is_ready == 0) + khttp_connect_file(fp); + } + if (fp->type == KNF_TYPE_LOCAL) { // on Windows, the following block is necessary; not on UNIX + size_t rest = len; + ssize_t curr; + while (rest) { + do { + curr = read(fp->fd, (void*)((char*)buf + l), rest); + } while (curr < 0 && EINTR == errno); + if (curr < 0) return -1; + if (curr == 0) break; + l += curr; rest -= curr; + } + } else l = my_netread(fp->fd, buf, len); + fp->offset += l; + return l; +} + +off_t knet_seek(knetFile *fp, off_t off, int whence) +{ + if (whence == SEEK_SET && off == fp->offset) return 0; + if (fp->type == KNF_TYPE_LOCAL) { + /* Be aware that lseek() returns the offset after seeking, while fseek() returns zero on success. */ + off_t offset = lseek(fp->fd, off, whence); + if (offset == -1) return -1; + fp->offset = offset; + return fp->offset; + } else if (fp->type == KNF_TYPE_FTP) { + if (whence == SEEK_CUR) fp->offset += off; + else if (whence == SEEK_SET) fp->offset = off; + else if (whence == SEEK_END) fp->offset = fp->file_size + off; + else return -1; + fp->is_ready = 0; + return fp->offset; + } else if (fp->type == KNF_TYPE_HTTP) { + if (whence == SEEK_END) { // FIXME: can we allow SEEK_END in future? + fprintf(stderr, "[knet_seek] SEEK_END is not supported for HTTP. Offset is unchanged.\n"); + errno = ESPIPE; + return -1; + } + if (whence == SEEK_CUR) fp->offset += off; + else if (whence == SEEK_SET) fp->offset = off; + else return -1; + fp->is_ready = 0; + return fp->offset; + } + errno = EINVAL; + fprintf(stderr,"[knet_seek] %s\n", strerror(errno)); + return -1; +} + +int knet_close(knetFile *fp) +{ + if (fp == 0) return 0; + if (fp->ctrl_fd != -1) netclose(fp->ctrl_fd); // FTP specific + if (fp->fd != -1) { + /* On Linux/Mac, netclose() is an alias of close(), but on + * Windows, it is an alias of closesocket(). */ + if (fp->type == KNF_TYPE_LOCAL) close(fp->fd); + else netclose(fp->fd); + } + free(fp->host); free(fp->port); + free(fp->response); free(fp->retr); // FTP specific + free(fp->path); free(fp->http_host); // HTTP specific + free(fp); + return 0; +} + +#ifdef KNETFILE_MAIN +int main(void) +{ + char *buf; + knetFile *fp; + int type = 4, l; +#ifdef _WIN32 + knet_win32_init(); +#endif + buf = calloc(0x100000, 1); + if (type == 0) { + fp = knet_open("knetfile.c", "r"); + knet_seek(fp, 1000, SEEK_SET); + } else if (type == 1) { // NCBI FTP, large file + fp = knet_open("ftp://ftp.ncbi.nih.gov/1000genomes/ftp/data/NA12878/alignment/NA12878.chrom6.SLX.SRP000032.2009_06.bam", "r"); + knet_seek(fp, 2500000000ll, SEEK_SET); + l = knet_read(fp, buf, 255); + } else if (type == 2) { + fp = knet_open("ftp://ftp.sanger.ac.uk/pub4/treefam/tmp/index.shtml", "r"); + knet_seek(fp, 1000, SEEK_SET); + } else if (type == 3) { + fp = knet_open("http://www.sanger.ac.uk/Users/lh3/index.shtml", "r"); + knet_seek(fp, 1000, SEEK_SET); + } else if (type == 4) { + fp = knet_open("http://www.sanger.ac.uk/Users/lh3/ex1.bam", "r"); + knet_read(fp, buf, 10000); + knet_seek(fp, 20000, SEEK_SET); + knet_seek(fp, 10000, SEEK_SET); + l = knet_read(fp, buf+10000, 10000000) + 10000; + } + if (type != 4 && type != 1) { + knet_read(fp, buf, 255); + buf[255] = 0; + printf("%s\n", buf); + } else write(fileno(stdout), buf, l); + knet_close(fp); + free(buf); + return 0; +} +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/kstring.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,254 @@ +/* The MIT License + + Copyright (C) 2011 by Attractive Chaos <attractor@live.co.uk> + + Permission is hereby granted, free of charge, to any person obtaining + a copy of this software and associated documentation files (the + "Software"), to deal in the Software without restriction, including + without limitation the rights to use, copy, modify, merge, publish, + distribute, sublicense, and/or sell copies of the Software, and to + permit persons to whom the Software is furnished to do so, subject to + the following conditions: + + The above copyright notice and this permission notice shall be + included in all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, + EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF + MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND + NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS + BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN + ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN + CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE + SOFTWARE. +*/ + +#include <stdarg.h> +#include <stdio.h> +#include <ctype.h> +#include <string.h> +#include <stdint.h> +#include "htslib/kstring.h" + +int kvsprintf(kstring_t *s, const char *fmt, va_list ap) +{ + va_list args; + int l; + va_copy(args, ap); + l = vsnprintf(s->s + s->l, s->m - s->l, fmt, args); // This line does not work with glibc 2.0. See `man snprintf'. + va_end(args); + if (l + 1 > s->m - s->l) { + s->m = s->l + l + 2; + kroundup32(s->m); + s->s = (char*)realloc(s->s, s->m); + va_copy(args, ap); + l = vsnprintf(s->s + s->l, s->m - s->l, fmt, args); + va_end(args); + } + s->l += l; + return l; +} + +int ksprintf(kstring_t *s, const char *fmt, ...) +{ + va_list ap; + int l; + va_start(ap, fmt); + l = kvsprintf(s, fmt, ap); + va_end(ap); + return l; +} + +char *kstrtok(const char *str, const char *sep, ks_tokaux_t *aux) +{ + const char *p, *start; + if (sep) { // set up the table + if (str == 0 && (aux->tab[0]&1)) return 0; // no need to set up if we have finished + aux->finished = 0; + if (sep[1]) { + aux->sep = -1; + aux->tab[0] = aux->tab[1] = aux->tab[2] = aux->tab[3] = 0; + for (p = sep; *p; ++p) aux->tab[*p>>6] |= 1ull<<(*p&0x3f); + } else aux->sep = sep[0]; + } + if (aux->finished) return 0; + else if (str) aux->p = str - 1, aux->finished = 0; + if (aux->sep < 0) { + for (p = start = aux->p + 1; *p; ++p) + if (aux->tab[*p>>6]>>(*p&0x3f)&1) break; + } else { + for (p = start = aux->p + 1; *p; ++p) + if (*p == aux->sep) break; + } + aux->p = p; // end of token + if (*p == 0) aux->finished = 1; // no more tokens + return (char*)start; +} + +// s MUST BE a null terminated string; l = strlen(s) +int ksplit_core(char *s, int delimiter, int *_max, int **_offsets) +{ + int i, n, max, last_char, last_start, *offsets, l; + n = 0; max = *_max; offsets = *_offsets; + l = strlen(s); + +#define __ksplit_aux do { \ + if (_offsets) { \ + s[i] = 0; \ + if (n == max) { \ + int *tmp; \ + max = max? max<<1 : 2; \ + if ((tmp = (int*)realloc(offsets, sizeof(int) * max))) { \ + offsets = tmp; \ + } else { \ + free(offsets); \ + *_offsets = NULL; \ + return 0; \ + } \ + } \ + offsets[n++] = last_start; \ + } else ++n; \ + } while (0) + + for (i = 0, last_char = last_start = 0; i <= l; ++i) { + if (delimiter == 0) { + if (isspace(s[i]) || s[i] == 0) { + if (isgraph(last_char)) __ksplit_aux; // the end of a field + } else { + if (isspace(last_char) || last_char == 0) last_start = i; + } + } else { + if (s[i] == delimiter || s[i] == 0) { + if (last_char != 0 && last_char != delimiter) __ksplit_aux; // the end of a field + } else { + if (last_char == delimiter || last_char == 0) last_start = i; + } + } + last_char = s[i]; + } + *_max = max; *_offsets = offsets; + return n; +} + +/********************** + * Boyer-Moore search * + **********************/ + +typedef unsigned char ubyte_t; + +// reference: http://www-igm.univ-mlv.fr/~lecroq/string/node14.html +static int *ksBM_prep(const ubyte_t *pat, int m) +{ + int i, *suff, *prep, *bmGs, *bmBc; + prep = (int*)calloc(m + 256, sizeof(int)); + bmGs = prep; bmBc = prep + m; + { // preBmBc() + for (i = 0; i < 256; ++i) bmBc[i] = m; + for (i = 0; i < m - 1; ++i) bmBc[pat[i]] = m - i - 1; + } + suff = (int*)calloc(m, sizeof(int)); + { // suffixes() + int f = 0, g; + suff[m - 1] = m; + g = m - 1; + for (i = m - 2; i >= 0; --i) { + if (i > g && suff[i + m - 1 - f] < i - g) + suff[i] = suff[i + m - 1 - f]; + else { + if (i < g) g = i; + f = i; + while (g >= 0 && pat[g] == pat[g + m - 1 - f]) --g; + suff[i] = f - g; + } + } + } + { // preBmGs() + int j = 0; + for (i = 0; i < m; ++i) bmGs[i] = m; + for (i = m - 1; i >= 0; --i) + if (suff[i] == i + 1) + for (; j < m - 1 - i; ++j) + if (bmGs[j] == m) + bmGs[j] = m - 1 - i; + for (i = 0; i <= m - 2; ++i) + bmGs[m - 1 - suff[i]] = m - 1 - i; + } + free(suff); + return prep; +} + +void *kmemmem(const void *_str, int n, const void *_pat, int m, int **_prep) +{ + int i, j, *prep = 0, *bmGs, *bmBc; + const ubyte_t *str, *pat; + str = (const ubyte_t*)_str; pat = (const ubyte_t*)_pat; + prep = (_prep == 0 || *_prep == 0)? ksBM_prep(pat, m) : *_prep; + if (_prep && *_prep == 0) *_prep = prep; + bmGs = prep; bmBc = prep + m; + j = 0; + while (j <= n - m) { + for (i = m - 1; i >= 0 && pat[i] == str[i+j]; --i); + if (i >= 0) { + int max = bmBc[str[i+j]] - m + 1 + i; + if (max < bmGs[i]) max = bmGs[i]; + j += max; + } else return (void*)(str + j); + } + if (_prep == 0) free(prep); + return 0; +} + +char *kstrstr(const char *str, const char *pat, int **_prep) +{ + return (char*)kmemmem(str, strlen(str), pat, strlen(pat), _prep); +} + +char *kstrnstr(const char *str, const char *pat, int n, int **_prep) +{ + return (char*)kmemmem(str, n, pat, strlen(pat), _prep); +} + +/*********************** + * The main() function * + ***********************/ + +#ifdef KSTRING_MAIN +#include <stdio.h> +int main() +{ + kstring_t *s; + int *fields, n, i; + ks_tokaux_t aux; + char *p; + s = (kstring_t*)calloc(1, sizeof(kstring_t)); + // test ksprintf() + ksprintf(s, " abcdefg: %d ", 100); + printf("'%s'\n", s->s); + // test ksplit() + fields = ksplit(s, 0, &n); + for (i = 0; i < n; ++i) + printf("field[%d] = '%s'\n", i, s->s + fields[i]); + // test kstrtok() + s->l = 0; + for (p = kstrtok("ab:cde:fg/hij::k", ":/", &aux); p; p = kstrtok(0, 0, &aux)) { + kputsn(p, aux.p - p, s); + kputc('\n', s); + } + printf("%s", s->s); + // free + free(s->s); free(s); free(fields); + + { + static char *str = "abcdefgcdgcagtcakcdcd"; + static char *pat = "cd"; + char *ret, *s = str; + int *prep = 0; + while ((ret = kstrstr(s, pat, &prep)) != 0) { + printf("match: %s\n", ret); + s = ret + prep[0]; + } + free(prep); + } + return 0; +} +#endif
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/regidx.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,338 @@ +/* + Copyright (C) 2014 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + + Permission is hereby granted, free of charge, to any person obtaining a copy + of this software and associated documentation files (the "Software"), to deal + in the Software without restriction, including without limitation the rights + to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + copies of the Software, and to permit persons to whom the Software is + furnished to do so, subject to the following conditions: + + The above copyright notice and this permission notice shall be included in + all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + THE SOFTWARE. +*/ + +#include "htslib/hts.h" +#include "htslib/kstring.h" +#include "htslib/kseq.h" +#include "htslib/khash_str2int.h" +#include "htslib/regidx.h" + +#define LIDX_SHIFT 13 // number of insignificant index bits + +// List of regions for one chromosome +typedef struct +{ + int *idx, nidx; + int nregs, mregs; // n:used, m:alloced + reg_t *regs; + void *payload; +} +reglist_t; + +// Container of all sequences +struct _regidx_t +{ + int nseq, mseq; // n:used, m:alloced + reglist_t *seq; // regions for each sequence + void *seq2regs; // hash for fast lookup from chr name to regions + char **seq_names; + regidx_free_f free; // function to free any data allocated by regidx_parse_f + regidx_parse_f parse; // parse one input line + void *usr; // user data to pass to regidx_parse_f + + // temporary data for index initialization + kstring_t str; + int rid_prev, start_prev, end_prev; + int payload_size; + void *payload; +}; + +int regidx_seq_nregs(regidx_t *idx, const char *seq) +{ + int iseq; + if ( khash_str2int_get(idx->seq2regs, seq, &iseq)!=0 ) return 0; // no such sequence + return idx->seq[iseq].nregs; +} + +int regidx_nregs(regidx_t *idx) +{ + int i, nregs = 0; + for (i=0; i<idx->nseq; i++) nregs += idx->seq[i].nregs; + return nregs; +} + +char **regidx_seq_names(regidx_t *idx, int *n) +{ + *n = idx->nseq; + return idx->seq_names; +} + +int _regidx_build_index(regidx_t *idx) +{ + int iseq; + for (iseq=0; iseq<idx->nseq; iseq++) + { + reglist_t *list = &idx->seq[iseq]; + int j,k, imax = 0; // max index bin + for (j=0; j<list->nregs; j++) + { + int ibeg = list->regs[j].start >> LIDX_SHIFT; + int iend = list->regs[j].end >> LIDX_SHIFT; + if ( imax < iend + 1 ) + { + int old_imax = imax; + imax = iend + 1; + kroundup32(imax); + list->idx = (int*) realloc(list->idx, imax*sizeof(int)); + for (k=old_imax; k<imax; k++) list->idx[k] = -1; + } + if ( ibeg==iend ) + { + if ( list->idx[ibeg]<0 ) list->idx[ibeg] = j; + } + else + { + for (k=ibeg; k<=iend; k++) + if ( list->idx[k]<0 ) list->idx[k] = j; + } + list->nidx = iend + 1; + } + } + return 0; +} + +int regidx_insert(regidx_t *idx, char *line) +{ + if ( !line ) + return _regidx_build_index(idx); + + char *chr_from, *chr_to; + reg_t reg; + int ret = idx->parse(line,&chr_from,&chr_to,®,idx->payload,idx->usr); + if ( ret==-2 ) return -1; // error + if ( ret==-1 ) return 0; // skip the line + + int rid; + idx->str.l = 0; + kputsn(chr_from, chr_to-chr_from+1, &idx->str); + if ( khash_str2int_get(idx->seq2regs, idx->str.s, &rid)!=0 ) + { + idx->nseq++; + int m_prev = idx->mseq; + hts_expand0(reglist_t,idx->nseq,idx->mseq,idx->seq); + hts_expand0(char*,idx->nseq,m_prev,idx->seq_names); + idx->seq_names[idx->nseq-1] = strdup(idx->str.s); + rid = khash_str2int_inc(idx->seq2regs, idx->seq_names[idx->nseq-1]); + } + + reglist_t *list = &idx->seq[rid]; + list->nregs++; + int m_prev = list->mregs; + hts_expand(reg_t,list->nregs,list->mregs,list->regs); + list->regs[list->nregs-1] = reg; + if ( idx->payload_size ) + { + if ( m_prev < list->mregs ) list->payload = realloc(list->payload,idx->payload_size*list->mregs); + memcpy(list->payload + idx->payload_size*(list->nregs-1), idx->payload, idx->payload_size); + } + + if ( idx->rid_prev==rid ) + { + if ( idx->start_prev > reg.start || (idx->start_prev==reg.start && idx->end_prev>reg.end) ) + { + fprintf(stderr,"The regions are not sorted: %s:%d-%d is before %s:%d-%d\n", + idx->str.s,idx->start_prev+1,idx->end_prev+1,idx->str.s,reg.start+1,reg.end+1); + return -1; + } + } + idx->rid_prev = rid; + idx->start_prev = reg.start; + idx->end_prev = reg.end; + return 0; +} + +regidx_t *regidx_init(const char *fname, regidx_parse_f parser, regidx_free_f free_f, size_t payload_size, void *usr_dat) +{ + if ( !parser ) + { + if ( !fname ) parser = regidx_parse_tab; + else + { + int len = strlen(fname); + if ( len>=7 && !strcasecmp(".bed.gz",fname+len-7) ) + parser = regidx_parse_bed; + else if ( len>=8 && !strcasecmp(".bed.bgz",fname+len-8) ) + parser = regidx_parse_bed; + else if ( len>=4 && !strcasecmp(".bed",fname+len-4) ) + parser = regidx_parse_bed; + else + parser = regidx_parse_tab; + } + } + + regidx_t *idx = (regidx_t*) calloc(1,sizeof(regidx_t)); + idx->free = free_f; + idx->parse = parser; + idx->usr = usr_dat; + idx->seq2regs = khash_str2int_init(); + idx->rid_prev = -1; + idx->start_prev = -1; + idx->end_prev = -1; + idx->payload_size = payload_size; + if ( payload_size ) idx->payload = malloc(payload_size); + + if ( !fname ) return idx; + + kstring_t str = {0,0,0}; + + htsFile *fp = hts_open(fname,"r"); + if ( !fp ) goto error; + + while ( hts_getline(fp, KS_SEP_LINE, &str) > 0 ) + { + if ( regidx_insert(idx, str.s) ) goto error; + } + regidx_insert(idx, NULL); + + free(str.s); + hts_close(fp); + return idx; + +error: + free(str.s); + if ( fp ) hts_close(fp); + regidx_destroy(idx); + return NULL; +} + +void regidx_destroy(regidx_t *idx) +{ + int i, j; + for (i=0; i<idx->nseq; i++) + { + reglist_t *list = &idx->seq[i]; + if ( idx->free ) + { + for (j=0; j<list->nregs; j++) + idx->free(list->payload + idx->payload_size*j); + } + free(list->payload); + free(list->regs); + free(list->idx); + } + free(idx->seq_names); + free(idx->seq); + free(idx->str.s); + free(idx->payload); + khash_str2int_destroy_free(idx->seq2regs); + free(idx); +} + +int regidx_overlap(regidx_t *idx, const char *chr, uint32_t from, uint32_t to, regitr_t *itr) +{ + if ( itr ) itr->i = itr->n = 0; + + int iseq; + if ( khash_str2int_get(idx->seq2regs, chr, &iseq)!=0 ) return 0; // no such sequence + + reglist_t *list = &idx->seq[iseq]; + if ( !list->nregs ) return 0; + + int i, ibeg = from>>LIDX_SHIFT; + int ireg = ibeg < list->nidx ? list->idx[ibeg] : list->idx[ list->nidx - 1 ]; + if ( ireg < 0 ) + { + // linear search; if slow, replace with binary search + if ( ibeg > list->nidx ) ibeg = list->nidx; + for (i=ibeg - 1; i>=0; i--) + if ( list->idx[i] >=0 ) break; + ireg = i>=0 ? list->idx[i] : 0; + } + for (i=ireg; i<list->nregs; i++) + { + if ( list->regs[i].start > to ) return 0; // no match + if ( list->regs[i].end >= from && list->regs[i].start <= to ) break; // found + } + + if ( i>=list->nregs ) return 0; // no match + + if ( !itr ) return 1; + + itr->i = 0; + itr->n = list->nregs - i; + itr->reg = &idx->seq[iseq].regs[i]; + if ( idx->payload_size ) + itr->payload = idx->seq[iseq].payload + i*idx->payload_size; + else + itr->payload = NULL; + + return 1; +} + +int regidx_parse_bed(const char *line, char **chr_beg, char **chr_end, reg_t *reg, void *payload, void *usr) +{ + char *ss = (char*) line; + while ( *ss && isspace(*ss) ) ss++; + if ( !*ss ) return -1; // skip blank lines + if ( *ss=='#' ) return -1; // skip comments + + char *se = ss; + while ( *se && !isspace(*se) ) se++; + if ( !*se ) { fprintf(stderr,"Could not parse bed line: %s\n", line); return -2; } + + *chr_beg = ss; + *chr_end = se-1; + + ss = se+1; + reg->start = strtol(ss, &se, 10); + if ( ss==se ) { fprintf(stderr,"Could not parse bed line: %s\n", line); return -2; } + + ss = se+1; + reg->end = strtol(ss, &se, 10) - 1; + if ( ss==se ) { fprintf(stderr,"Could not parse bed line: %s\n", line); return -2; } + + return 0; +} + +int regidx_parse_tab(const char *line, char **chr_beg, char **chr_end, reg_t *reg, void *payload, void *usr) +{ + char *ss = (char*) line; + while ( *ss && isspace(*ss) ) ss++; + if ( !*ss ) return -1; // skip blank lines + if ( *ss=='#' ) return -1; // skip comments + + char *se = ss; + while ( *se && !isspace(*se) ) se++; + if ( !*se ) { fprintf(stderr,"Could not parse bed line: %s\n", line); return -2; } + + *chr_beg = ss; + *chr_end = se-1; + + ss = se+1; + reg->start = strtol(ss, &se, 10) - 1; + if ( ss==se ) { fprintf(stderr,"Could not parse bed line: %s\n", line); return -2; } + + if ( !se[0] || !se[1] ) + reg->end = reg->start; + else + { + ss = se+1; + reg->end = strtol(ss, &se, 10); + if ( ss==se ) reg->end = reg->start; + else reg->end--; + } + + return 0; +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/sam.5 Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,68 @@ +'\" t +.TH sam 5 "August 2013" "htslib" "Bioinformatics formats" +.SH NAME +sam \- Sequence Alignment/Map file format +.\" +.\" Copyright (C) 2009, 2013 Genome Research Ltd. +.\" +.\" Author: Heng Li <lh3@sanger.ac.uk> +.\" +.\" Permission is hereby granted, free of charge, to any person obtaining a +.\" copy of this software and associated documentation files (the "Software"), +.\" to deal in the Software without restriction, including without limitation +.\" the rights to use, copy, modify, merge, publish, distribute, sublicense, +.\" and/or sell copies of the Software, and to permit persons to whom the +.\" Software is furnished to do so, subject to the following conditions: +.\" +.\" The above copyright notice and this permission notice shall be included in +.\" all copies or substantial portions of the Software. +.\" +.\" THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +.\" IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +.\" FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +.\" THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +.\" LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +.\" FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +.\" DEALINGS IN THE SOFTWARE. +.\" +.SH DESCRIPTION +Sequence Alignment/Map (SAM) format is TAB-delimited. Apart from the header lines, which are started +with the `@' symbol, each alignment line consists of: +.TS +nlbl. +1 QNAME Query template/pair NAME +2 FLAG bitwise FLAG +3 RNAME Reference sequence NAME +4 POS 1-based leftmost POSition/coordinate of clipped sequence +5 MAPQ MAPping Quality (Phred-scaled) +6 CIGAR extended CIGAR string +7 MRNM Mate Reference sequence NaMe (`=' if same as RNAME) +8 MPOS 1-based Mate POSistion +9 TLEN inferred Template LENgth (insert size) +10 SEQ query SEQuence on the same strand as the reference +11 QUAL query QUALity (ASCII-33 gives the Phred base quality) +12+ OPT variable OPTional fields in the format TAG:VTYPE:VALUE +.TE +.PP +Each bit in the FLAG field is defined as: +.TS +lcbl. +0x0001 p the read is paired in sequencing +0x0002 P the read is mapped in a proper pair +0x0004 u the query sequence itself is unmapped +0x0008 U the mate is unmapped +0x0010 r strand of the query (1 for reverse) +0x0020 R strand of the mate +0x0040 1 the read is the first read in a pair +0x0080 2 the read is the second read in a pair +0x0100 s the alignment is not primary +0x0200 f the read fails platform/vendor quality checks +0x0400 d the read is either a PCR or an optical duplicate +0x0800 S the alignment is supplementary +.TE +.P +where the second column gives the string representation of the FLAG field. +.SH SEE ALSO +.TP +https://github.com/samtools/hts-specs +The full SAM/BAM file format specification
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/sam.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1882 @@ +/* sam.c -- SAM and BAM file I/O and manipulation. + + Copyright (C) 2008-2010, 2012-2014 Genome Research Ltd. + Copyright (C) 2010, 2012, 2013 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> +#include <stdlib.h> +#include <string.h> +#include <errno.h> +#include <ctype.h> +#include <zlib.h> +#include "htslib/sam.h" +#include "htslib/bgzf.h" +#include "cram/cram.h" +#include "htslib/hfile.h" + +#include "htslib/khash.h" +KHASH_DECLARE(s2i, kh_cstr_t, int64_t) + +typedef khash_t(s2i) sdict_t; + +/********************** + *** BAM header I/O *** + **********************/ + +bam_hdr_t *bam_hdr_init() +{ + return (bam_hdr_t*)calloc(1, sizeof(bam_hdr_t)); +} + +void bam_hdr_destroy(bam_hdr_t *h) +{ + int32_t i; + if (h == NULL) return; + if (h->target_name) { + for (i = 0; i < h->n_targets; ++i) + free(h->target_name[i]); + free(h->target_name); + free(h->target_len); + } + free(h->text); free(h->cigar_tab); + if (h->sdict) kh_destroy(s2i, (sdict_t*)h->sdict); + free(h); +} + +bam_hdr_t *bam_hdr_dup(const bam_hdr_t *h0) +{ + if (h0 == NULL) return NULL; + bam_hdr_t *h; + if ((h = bam_hdr_init()) == NULL) return NULL; + // copy the simple data + h->n_targets = h0->n_targets; + h->ignore_sam_err = h0->ignore_sam_err; + h->l_text = h0->l_text; + // Then the pointery stuff + h->cigar_tab = NULL; + h->sdict = NULL; + h->text = (char*)calloc(h->l_text + 1, 1); + memcpy(h->text, h0->text, h->l_text); + h->target_len = (uint32_t*)calloc(h->n_targets, sizeof(uint32_t)); + h->target_name = (char**)calloc(h->n_targets, sizeof(char*)); + int i; + for (i = 0; i < h->n_targets; ++i) { + h->target_len[i] = h0->target_len[i]; + h->target_name[i] = strdup(h0->target_name[i]); + } + return h; +} + + +static bam_hdr_t *hdr_from_dict(sdict_t *d) +{ + bam_hdr_t *h; + khint_t k; + h = bam_hdr_init(); + h->sdict = d; + h->n_targets = kh_size(d); + h->target_len = (uint32_t*)malloc(sizeof(uint32_t) * h->n_targets); + h->target_name = (char**)malloc(sizeof(char*) * h->n_targets); + for (k = kh_begin(d); k != kh_end(d); ++k) { + if (!kh_exist(d, k)) continue; + h->target_name[kh_val(d, k)>>32] = (char*)kh_key(d, k); + h->target_len[kh_val(d, k)>>32] = kh_val(d, k)<<32>>32; + kh_val(d, k) >>= 32; + } + return h; +} + +bam_hdr_t *bam_hdr_read(BGZF *fp) +{ + bam_hdr_t *h; + char buf[4]; + int magic_len, has_EOF; + int32_t i = 1, name_len; + // check EOF + has_EOF = bgzf_check_EOF(fp); + if (has_EOF < 0) { + perror("[W::sam_hdr_read] bgzf_check_EOF"); + } else if (has_EOF == 0 && hts_verbose >= 2) + fprintf(stderr, "[W::%s] EOF marker is absent. The input is probably truncated.\n", __func__); + // read "BAM1" + magic_len = bgzf_read(fp, buf, 4); + if (magic_len != 4 || strncmp(buf, "BAM\1", 4)) { + if (hts_verbose >= 1) fprintf(stderr, "[E::%s] invalid BAM binary header\n", __func__); + return 0; + } + h = bam_hdr_init(); + // read plain text and the number of reference sequences + bgzf_read(fp, &h->l_text, 4); + if (fp->is_be) ed_swap_4p(&h->l_text); + h->text = (char*)malloc(h->l_text + 1); + h->text[h->l_text] = 0; // make sure it is NULL terminated + bgzf_read(fp, h->text, h->l_text); + bgzf_read(fp, &h->n_targets, 4); + if (fp->is_be) ed_swap_4p(&h->n_targets); + // read reference sequence names and lengths + h->target_name = (char**)calloc(h->n_targets, sizeof(char*)); + h->target_len = (uint32_t*)calloc(h->n_targets, sizeof(uint32_t)); + for (i = 0; i != h->n_targets; ++i) { + bgzf_read(fp, &name_len, 4); + if (fp->is_be) ed_swap_4p(&name_len); + h->target_name[i] = (char*)calloc(name_len, 1); + bgzf_read(fp, h->target_name[i], name_len); + bgzf_read(fp, &h->target_len[i], 4); + if (fp->is_be) ed_swap_4p(&h->target_len[i]); + } + return h; +} + +int bam_hdr_write(BGZF *fp, const bam_hdr_t *h) +{ + char buf[4]; + int32_t i, name_len, x; + // write "BAM1" + strncpy(buf, "BAM\1", 4); + bgzf_write(fp, buf, 4); + // write plain text and the number of reference sequences + if (fp->is_be) { + x = ed_swap_4(h->l_text); + bgzf_write(fp, &x, 4); + if (h->l_text) bgzf_write(fp, h->text, h->l_text); + x = ed_swap_4(h->n_targets); + bgzf_write(fp, &x, 4); + } else { + bgzf_write(fp, &h->l_text, 4); + if (h->l_text) bgzf_write(fp, h->text, h->l_text); + bgzf_write(fp, &h->n_targets, 4); + } + // write sequence names and lengths + for (i = 0; i != h->n_targets; ++i) { + char *p = h->target_name[i]; + name_len = strlen(p) + 1; + if (fp->is_be) { + x = ed_swap_4(name_len); + bgzf_write(fp, &x, 4); + } else bgzf_write(fp, &name_len, 4); + bgzf_write(fp, p, name_len); + if (fp->is_be) { + x = ed_swap_4(h->target_len[i]); + bgzf_write(fp, &x, 4); + } else bgzf_write(fp, &h->target_len[i], 4); + } + bgzf_flush(fp); + return 0; +} + +int bam_name2id(bam_hdr_t *h, const char *ref) +{ + sdict_t *d = (sdict_t*)h->sdict; + khint_t k; + if (h->sdict == 0) { + int i, absent; + d = kh_init(s2i); + for (i = 0; i < h->n_targets; ++i) { + k = kh_put(s2i, d, h->target_name[i], &absent); + kh_val(d, k) = i; + } + h->sdict = d; + } + k = kh_get(s2i, d, ref); + return k == kh_end(d)? -1 : kh_val(d, k); +} + +/************************* + *** BAM alignment I/O *** + *************************/ + +bam1_t *bam_init1() +{ + return (bam1_t*)calloc(1, sizeof(bam1_t)); +} + +void bam_destroy1(bam1_t *b) +{ + if (b == 0) return; + free(b->data); free(b); +} + +bam1_t *bam_copy1(bam1_t *bdst, const bam1_t *bsrc) +{ + uint8_t *data = bdst->data; + int m_data = bdst->m_data; // backup data and m_data + if (m_data < bsrc->l_data) { // double the capacity + m_data = bsrc->l_data; kroundup32(m_data); + data = (uint8_t*)realloc(data, m_data); + } + memcpy(data, bsrc->data, bsrc->l_data); // copy var-len data + *bdst = *bsrc; // copy the rest + // restore the backup + bdst->m_data = m_data; + bdst->data = data; + return bdst; +} + +bam1_t *bam_dup1(const bam1_t *bsrc) +{ + if (bsrc == NULL) return NULL; + bam1_t *bdst = bam_init1(); + if (bdst == NULL) return NULL; + return bam_copy1(bdst, bsrc); +} + +int bam_cigar2qlen(int n_cigar, const uint32_t *cigar) +{ + int k, l; + for (k = l = 0; k < n_cigar; ++k) + if (bam_cigar_type(bam_cigar_op(cigar[k]))&1) + l += bam_cigar_oplen(cigar[k]); + return l; +} + +int bam_cigar2rlen(int n_cigar, const uint32_t *cigar) +{ + int k, l; + for (k = l = 0; k < n_cigar; ++k) + if (bam_cigar_type(bam_cigar_op(cigar[k]))&2) + l += bam_cigar_oplen(cigar[k]); + return l; +} + +int32_t bam_endpos(const bam1_t *b) +{ + if (!(b->core.flag & BAM_FUNMAP) && b->core.n_cigar > 0) + return b->core.pos + bam_cigar2rlen(b->core.n_cigar, bam_get_cigar(b)); + else + return b->core.pos + 1; +} + +static inline int aux_type2size(uint8_t type) +{ + switch (type) { + case 'A': case 'c': case 'C': + return 1; + case 's': case 'S': + return 2; + case 'i': case 'I': case 'f': + return 4; + case 'd': + return 8; + case 'Z': case 'H': case 'B': + return type; + default: + return 0; + } +} + +static void swap_data(const bam1_core_t *c, int l_data, uint8_t *data, int is_host) +{ + uint8_t *s; + uint32_t *cigar = (uint32_t*)(data + c->l_qname); + uint32_t i, n; + s = data + c->n_cigar*4 + c->l_qname + c->l_qseq + (c->l_qseq + 1)/2; + for (i = 0; i < c->n_cigar; ++i) ed_swap_4p(&cigar[i]); + while (s < data + l_data) { + int size; + s += 2; // skip key + size = aux_type2size(*s); ++s; // skip type + switch (size) { + case 1: ++s; break; + case 2: ed_swap_2p(s); s += 2; break; + case 4: ed_swap_4p(s); s += 4; break; + case 8: ed_swap_8p(s); s += 8; break; + case 'Z': + case 'H': + while (*s) ++s; + ++s; + break; + case 'B': + size = aux_type2size(*s); ++s; + if (is_host) memcpy(&n, s, 4), ed_swap_4p(s); + else ed_swap_4p(s), memcpy(&n, s, 4); + s += 4; + switch (size) { + case 1: s += n; break; + case 2: for (i = 0; i < n; ++i, s += 2) ed_swap_2p(s); break; + case 4: for (i = 0; i < n; ++i, s += 4) ed_swap_4p(s); break; + case 8: for (i = 0; i < n; ++i, s += 8) ed_swap_8p(s); break; + } + break; + } + } +} + +int bam_read1(BGZF *fp, bam1_t *b) +{ + bam1_core_t *c = &b->core; + int32_t block_len, ret, i; + uint32_t x[8]; + if ((ret = bgzf_read(fp, &block_len, 4)) != 4) { + if (ret == 0) return -1; // normal end-of-file + else return -2; // truncated + } + if (bgzf_read(fp, x, 32) != 32) return -3; + if (fp->is_be) { + ed_swap_4p(&block_len); + for (i = 0; i < 8; ++i) ed_swap_4p(x + i); + } + c->tid = x[0]; c->pos = x[1]; + c->bin = x[2]>>16; c->qual = x[2]>>8&0xff; c->l_qname = x[2]&0xff; + c->flag = x[3]>>16; c->n_cigar = x[3]&0xffff; + c->l_qseq = x[4]; + c->mtid = x[5]; c->mpos = x[6]; c->isize = x[7]; + b->l_data = block_len - 32; + if (b->l_data < 0 || c->l_qseq < 0) return -4; + if ((char *)bam_get_aux(b) - (char *)b->data > b->l_data) + return -4; + if (b->m_data < b->l_data) { + b->m_data = b->l_data; + kroundup32(b->m_data); + b->data = (uint8_t*)realloc(b->data, b->m_data); + if (!b->data) + return -4; + } + if (bgzf_read(fp, b->data, b->l_data) != b->l_data) return -4; + //b->l_aux = b->l_data - c->n_cigar * 4 - c->l_qname - c->l_qseq - (c->l_qseq+1)/2; + if (fp->is_be) swap_data(c, b->l_data, b->data, 0); + return 4 + block_len; +} + +int bam_write1(BGZF *fp, const bam1_t *b) +{ + const bam1_core_t *c = &b->core; + uint32_t x[8], block_len = b->l_data + 32, y; + int i, ok; + x[0] = c->tid; + x[1] = c->pos; + x[2] = (uint32_t)c->bin<<16 | c->qual<<8 | c->l_qname; + x[3] = (uint32_t)c->flag<<16 | c->n_cigar; + x[4] = c->l_qseq; + x[5] = c->mtid; + x[6] = c->mpos; + x[7] = c->isize; + ok = (bgzf_flush_try(fp, 4 + block_len) >= 0); + if (fp->is_be) { + for (i = 0; i < 8; ++i) ed_swap_4p(x + i); + y = block_len; + if (ok) ok = (bgzf_write(fp, ed_swap_4p(&y), 4) >= 0); + swap_data(c, b->l_data, b->data, 1); + } else { + if (ok) ok = (bgzf_write(fp, &block_len, 4) >= 0); + } + if (ok) ok = (bgzf_write(fp, x, 32) >= 0); + if (ok) ok = (bgzf_write(fp, b->data, b->l_data) >= 0); + if (fp->is_be) swap_data(c, b->l_data, b->data, 0); + return ok? 4 + block_len : -1; +} + +/******************** + *** BAM indexing *** + ********************/ + +static hts_idx_t *bam_index(BGZF *fp, int min_shift) +{ + int n_lvls, i, fmt; + bam1_t *b; + hts_idx_t *idx; + bam_hdr_t *h; + h = bam_hdr_read(fp); + if (min_shift > 0) { + int64_t max_len = 0, s; + for (i = 0; i < h->n_targets; ++i) + if (max_len < h->target_len[i]) max_len = h->target_len[i]; + max_len += 256; + for (n_lvls = 0, s = 1<<min_shift; max_len > s; ++n_lvls, s <<= 3); + fmt = HTS_FMT_CSI; + } else min_shift = 14, n_lvls = 5, fmt = HTS_FMT_BAI; + idx = hts_idx_init(h->n_targets, fmt, bgzf_tell(fp), min_shift, n_lvls); + bam_hdr_destroy(h); + b = bam_init1(); + while (bam_read1(fp, b) >= 0) { + int l, ret; + l = bam_cigar2rlen(b->core.n_cigar, bam_get_cigar(b)); + if (l == 0) l = 1; // no zero-length records + ret = hts_idx_push(idx, b->core.tid, b->core.pos, b->core.pos + l, bgzf_tell(fp), !(b->core.flag&BAM_FUNMAP)); + if (ret < 0) + { + // unsorted + bam_destroy1(b); + hts_idx_destroy(idx); + return NULL; + } + } + hts_idx_finish(idx, bgzf_tell(fp)); + bam_destroy1(b); + return idx; +} + +int bam_index_build(const char *fn, int min_shift) +{ + hts_idx_t *idx; + htsFile *fp; + int ret = 0; + + if ((fp = hts_open(fn, "r")) == 0) return -1; + switch (fp->format.format) { + case cram: + ret = cram_index_build(fp->fp.cram, fn); + break; + + case bam: + idx = bam_index(fp->fp.bgzf, min_shift); + if (idx) { + hts_idx_save(idx, fn, (min_shift > 0)? HTS_FMT_CSI : HTS_FMT_BAI); + hts_idx_destroy(idx); + } + else ret = -1; + break; + + default: + ret = -1; + break; + } + hts_close(fp); + + return ret; +} + +static int bam_readrec(BGZF *fp, void *ignored, void *bv, int *tid, int *beg, int *end) +{ + bam1_t *b = bv; + int ret; + if ((ret = bam_read1(fp, b)) >= 0) { + *tid = b->core.tid; *beg = b->core.pos; + *end = b->core.pos + (b->core.n_cigar? bam_cigar2rlen(b->core.n_cigar, bam_get_cigar(b)) : 1); + } + return ret; +} + +// This is used only with read_rest=1 iterators, so need not set tid/beg/end. +static int cram_readrec(BGZF *ignored, void *fpv, void *bv, int *tid, int *beg, int *end) +{ + htsFile *fp = fpv; + bam1_t *b = bv; + return cram_get_bam_seq(fp->fp.cram, &b); +} + +// This is used only with read_rest=1 iterators, so need not set tid/beg/end. +static int sam_bam_cram_readrec(BGZF *bgzfp, void *fpv, void *bv, int *tid, int *beg, int *end) +{ + htsFile *fp = fpv; + bam1_t *b = bv; + switch (fp->format.format) { + case bam: return bam_read1(bgzfp, b); + case cram: return cram_get_bam_seq(fp->fp.cram, &b); + default: + // TODO Need headers available to implement this for SAM files + fprintf(stderr, "[sam_bam_cram_readrec] Not implemented for SAM files -- Exiting\n"); + abort(); + } +} + +// The CRAM implementation stores the loaded index within the cram_fd rather +// than separately as is done elsewhere in htslib. So if p is a pointer to +// an hts_idx_t with p->fmt == HTS_FMT_CRAI, then it actually points to an +// hts_cram_idx_t and should be cast accordingly. +typedef struct hts_cram_idx_t { + int fmt; + cram_fd *cram; +} hts_cram_idx_t; + +hts_idx_t *sam_index_load(samFile *fp, const char *fn) +{ + switch (fp->format.format) { + case bam: + return bam_index_load(fn); + + case cram: { + if (cram_index_load(fp->fp.cram, fn) < 0) return NULL; + // Cons up a fake "index" just pointing at the associated cram_fd: + hts_cram_idx_t *idx = malloc(sizeof (hts_cram_idx_t)); + if (idx == NULL) return NULL; + idx->fmt = HTS_FMT_CRAI; + idx->cram = fp->fp.cram; + return (hts_idx_t *) idx; + } + + default: + return NULL; // TODO Would use tbx_index_load if it returned hts_idx_t + } +} + +static hts_itr_t *cram_itr_query(const hts_idx_t *idx, int tid, int beg, int end, hts_readrec_func *readrec) +{ + const hts_cram_idx_t *cidx = (const hts_cram_idx_t *) idx; + hts_itr_t *iter = (hts_itr_t *) calloc(1, sizeof(hts_itr_t)); + if (iter == NULL) return NULL; + + // Cons up a dummy iterator for which hts_itr_next() will simply invoke + // the readrec function: + iter->read_rest = 1; + iter->off = NULL; + iter->bins.a = NULL; + iter->readrec = readrec; + + if (tid >= 0) { + cram_range r = { tid, beg+1, end }; + if (cram_set_option(cidx->cram, CRAM_OPT_RANGE, &r) != 0) { free(iter); return NULL; } + iter->curr_off = 0; + // The following fields are not required by hts_itr_next(), but are + // filled in in case user code wants to look at them. + iter->tid = tid; + iter->beg = beg; + iter->end = end; + } + else switch (tid) { + case HTS_IDX_REST: + iter->curr_off = 0; + break; + case HTS_IDX_NONE: + iter->curr_off = 0; + iter->finished = 1; + break; + default: + fprintf(stderr, "[cram_itr_query] tid=%d not implemented for CRAM files -- Exiting\n", tid); + abort(); + break; + } + + return iter; +} + +hts_itr_t *sam_itr_queryi(const hts_idx_t *idx, int tid, int beg, int end) +{ + const hts_cram_idx_t *cidx = (const hts_cram_idx_t *) idx; + if (idx == NULL) + return hts_itr_query(NULL, tid, beg, end, sam_bam_cram_readrec); + else if (cidx->fmt == HTS_FMT_CRAI) + return cram_itr_query(idx, tid, beg, end, cram_readrec); + else + return hts_itr_query(idx, tid, beg, end, bam_readrec); +} + +static int cram_name2id(void *fdv, const char *ref) +{ + cram_fd *fd = (cram_fd *) fdv; + return sam_hdr_name2ref(fd->header, ref); +} + +hts_itr_t *sam_itr_querys(const hts_idx_t *idx, bam_hdr_t *hdr, const char *region) +{ + const hts_cram_idx_t *cidx = (const hts_cram_idx_t *) idx; + if (cidx->fmt == HTS_FMT_CRAI) + return hts_itr_querys(idx, region, cram_name2id, cidx->cram, cram_itr_query, cram_readrec); + else + return hts_itr_querys(idx, region, (hts_name2id_f)(bam_name2id), hdr, hts_itr_query, bam_readrec); +} + +/********************** + *** SAM header I/O *** + **********************/ + +#include "htslib/kseq.h" +#include "htslib/kstring.h" + +bam_hdr_t *sam_hdr_parse(int l_text, const char *text) +{ + const char *q, *r, *p; + khash_t(s2i) *d; + d = kh_init(s2i); + for (p = text; *p; ++p) { + if (strncmp(p, "@SQ", 3) == 0) { + char *sn = 0; + int ln = -1; + for (q = p + 4;; ++q) { + if (strncmp(q, "SN:", 3) == 0) { + q += 3; + for (r = q; *r != '\t' && *r != '\n'; ++r); + sn = (char*)calloc(r - q + 1, 1); + strncpy(sn, q, r - q); + q = r; + } else if (strncmp(q, "LN:", 3) == 0) + ln = strtol(q + 3, (char**)&q, 10); + while (*q != '\t' && *q != '\n') ++q; + if (*q == '\n') break; + } + p = q; + if (sn && ln >= 0) { + khint_t k; + int absent; + k = kh_put(s2i, d, sn, &absent); + if (!absent) { + if (hts_verbose >= 2) + fprintf(stderr, "[W::%s] duplicated sequence '%s'\n", __func__, sn); + free(sn); + } else kh_val(d, k) = (int64_t)(kh_size(d) - 1)<<32 | ln; + } + } + while (*p != '\n') ++p; + } + return hdr_from_dict(d); +} + +bam_hdr_t *sam_hdr_read(htsFile *fp) +{ + switch (fp->format.format) { + case bam: + return bam_hdr_read(fp->fp.bgzf); + + case cram: + return cram_header_to_bam(fp->fp.cram->header); + + case sam: { + kstring_t str; + bam_hdr_t *h; + int has_SQ = 0; + str.l = str.m = 0; str.s = 0; + while (hts_getline(fp, KS_SEP_LINE, &fp->line) >= 0) { + if (fp->line.s[0] != '@') break; + if (fp->line.l > 3 && strncmp(fp->line.s,"@SQ",3) == 0) has_SQ = 1; + kputsn(fp->line.s, fp->line.l, &str); + kputc('\n', &str); + } + if (! has_SQ && fp->fn_aux) { + char line[2048]; + FILE *f = fopen(fp->fn_aux, "r"); + if (f == NULL) return NULL; + while (fgets(line, sizeof line, f)) { + const char *name = strtok(line, "\t"); + const char *length = strtok(NULL, "\t"); + ksprintf(&str, "@SQ\tSN:%s\tLN:%s\n", name, length); + } + fclose(f); + } + if (str.l == 0) kputsn("", 0, &str); + h = sam_hdr_parse(str.l, str.s); + h->l_text = str.l; h->text = str.s; + return h; + } + + default: + abort(); + } +} + +int sam_hdr_write(htsFile *fp, const bam_hdr_t *h) +{ + switch (fp->format.format) { + case binary_format: + fp->format.category = sequence_data; + fp->format.format = bam; + /* fall-through */ + case bam: + bam_hdr_write(fp->fp.bgzf, h); + break; + + case cram: { + cram_fd *fd = fp->fp.cram; + if (cram_set_header(fd, bam_header_to_cram((bam_hdr_t *)h)) < 0) return -1; + if (fp->fn_aux) + cram_load_reference(fd, fp->fn_aux); + if (cram_write_SAM_hdr(fd, fd->header) < 0) return -1; + } + break; + + case text_format: + fp->format.category = sequence_data; + fp->format.format = sam; + /* fall-through */ + case sam: { + char *p; + hputs(h->text, fp->fp.hfile); + p = strstr(h->text, "@SQ\t"); // FIXME: we need a loop to make sure "@SQ\t" does not match something unwanted!!! + if (p == 0) { + int i; + for (i = 0; i < h->n_targets; ++i) { + fp->line.l = 0; + kputsn("@SQ\tSN:", 7, &fp->line); kputs(h->target_name[i], &fp->line); + kputsn("\tLN:", 4, &fp->line); kputw(h->target_len[i], &fp->line); kputc('\n', &fp->line); + if ( hwrite(fp->fp.hfile, fp->line.s, fp->line.l) != fp->line.l ) return -1; + } + } + if ( hflush(fp->fp.hfile) != 0 ) return -1; + } + break; + + default: + abort(); + } + return 0; +} + +/********************** + *** SAM record I/O *** + **********************/ + +int sam_parse1(kstring_t *s, bam_hdr_t *h, bam1_t *b) +{ +#define _read_token(_p) (_p); for (; *(_p) && *(_p) != '\t'; ++(_p)); if (*(_p) != '\t') goto err_ret; *(_p)++ = 0 +#define _read_token_aux(_p) (_p); for (; *(_p) && *(_p) != '\t'; ++(_p)); *(_p)++ = 0 // this is different in that it does not test *(_p)=='\t' +#define _get_mem(type_t, _x, _s, _l) ks_resize((_s), (_s)->l + (_l)); *(_x) = (type_t*)((_s)->s + (_s)->l); (_s)->l += (_l) +#define _parse_err(cond, msg) do { if ((cond) && hts_verbose >= 1) { fprintf(stderr, "[E::%s] " msg "\n", __func__); goto err_ret; } } while (0) +#define _parse_warn(cond, msg) if ((cond) && hts_verbose >= 2) fprintf(stderr, "[W::%s] " msg "\n", __func__) + + uint8_t *t; + char *p = s->s, *q; + int i; + kstring_t str; + bam1_core_t *c = &b->core; + + str.l = b->l_data = 0; + str.s = (char*)b->data; str.m = b->m_data; + memset(c, 0, 32); + if (h->cigar_tab == 0) { + h->cigar_tab = (int8_t*) malloc(128); + for (i = 0; i < 128; ++i) + h->cigar_tab[i] = -1; + for (i = 0; BAM_CIGAR_STR[i]; ++i) + h->cigar_tab[(int)BAM_CIGAR_STR[i]] = i; + } + // qname + q = _read_token(p); + kputsn_(q, p - q, &str); + c->l_qname = p - q; + // flag + c->flag = strtol(p, &p, 0); + if (*p++ != '\t') goto err_ret; // malformated flag + // chr + q = _read_token(p); + if (strcmp(q, "*")) { + _parse_err(h->n_targets == 0, "missing SAM header"); + c->tid = bam_name2id(h, q); + _parse_warn(c->tid < 0, "urecognized reference name; treated as unmapped"); + } else c->tid = -1; + // pos + c->pos = strtol(p, &p, 10) - 1; + if (*p++ != '\t') goto err_ret; + if (c->pos < 0 && c->tid >= 0) { + _parse_warn(1, "mapped query cannot have zero coordinate; treated as unmapped"); + c->tid = -1; + } + if (c->tid < 0) c->flag |= BAM_FUNMAP; + // mapq + c->qual = strtol(p, &p, 10); + if (*p++ != '\t') goto err_ret; + // cigar + if (*p != '*') { + uint32_t *cigar; + size_t n_cigar = 0; + for (q = p; *p && *p != '\t'; ++p) + if (!isdigit(*p)) ++n_cigar; + if (*p++ != '\t') goto err_ret; + _parse_err(n_cigar >= 65536, "too many CIGAR operations"); + c->n_cigar = n_cigar; + _get_mem(uint32_t, &cigar, &str, c->n_cigar<<2); + for (i = 0; i < c->n_cigar; ++i, ++q) { + int op; + cigar[i] = strtol(q, &q, 10)<<BAM_CIGAR_SHIFT; + op = (uint8_t)*q >= 128? -1 : h->cigar_tab[(int)*q]; + _parse_err(op < 0, "unrecognized CIGAR operator"); + cigar[i] |= op; + } + i = bam_cigar2rlen(c->n_cigar, cigar); + } else { + _parse_warn(!(c->flag&BAM_FUNMAP), "mapped query must have a CIGAR; treated as unmapped"); + c->flag |= BAM_FUNMAP; + q = _read_token(p); + i = 1; + } + c->bin = hts_reg2bin(c->pos, c->pos + i, 14, 5); + // mate chr + q = _read_token(p); + if (strcmp(q, "=") == 0) c->mtid = c->tid; + else if (strcmp(q, "*") == 0) c->mtid = -1; + else c->mtid = bam_name2id(h, q); + // mpos + c->mpos = strtol(p, &p, 10) - 1; + if (*p++ != '\t') goto err_ret; + if (c->mpos < 0 && c->mtid >= 0) { + _parse_warn(1, "mapped mate cannot have zero coordinate; treated as unmapped"); + c->mtid = -1; + } + // tlen + c->isize = strtol(p, &p, 10); + if (*p++ != '\t') goto err_ret; + // seq + q = _read_token(p); + if (strcmp(q, "*")) { + c->l_qseq = p - q - 1; + i = bam_cigar2qlen(c->n_cigar, (uint32_t*)(str.s + c->l_qname)); + _parse_err(c->n_cigar && i != c->l_qseq, "CIGAR and query sequence are of different length"); + i = (c->l_qseq + 1) >> 1; + _get_mem(uint8_t, &t, &str, i); + memset(t, 0, i); + for (i = 0; i < c->l_qseq; ++i) + t[i>>1] |= seq_nt16_table[(int)q[i]] << ((~i&1)<<2); + } else c->l_qseq = 0; + // qual + q = _read_token_aux(p); + _get_mem(uint8_t, &t, &str, c->l_qseq); + if (strcmp(q, "*")) { + _parse_err(p - q - 1 != c->l_qseq, "SEQ and QUAL are of different length"); + for (i = 0; i < c->l_qseq; ++i) t[i] = q[i] - 33; + } else memset(t, 0xff, c->l_qseq); + // aux + // Note that (like the bam1_core_t fields) this aux data in b->data is + // stored in host endianness; so there is no byte swapping needed here. + while (p < s->s + s->l) { + uint8_t type; + q = _read_token_aux(p); // FIXME: can be accelerated for long 'B' arrays + _parse_err(p - q - 1 < 6, "incomplete aux field"); + kputsn_(q, 2, &str); + q += 3; type = *q++; ++q; // q points to value + if (type == 'A' || type == 'a' || type == 'c' || type == 'C') { + kputc_('A', &str); + kputc_(*q, &str); + } else if (type == 'i' || type == 'I') { + if (*q == '-') { + long x = strtol(q, &q, 10); + if (x >= INT8_MIN) { + kputc_('c', &str); kputc_(x, &str); + } else if (x >= INT16_MIN) { + int16_t y = x; + kputc_('s', &str); kputsn_((char*)&y, 2, &str); + } else { + int32_t y = x; + kputc_('i', &str); kputsn_(&y, 4, &str); + } + } else { + unsigned long x = strtoul(q, &q, 10); + if (x <= UINT8_MAX) { + kputc_('C', &str); kputc_(x, &str); + } else if (x <= UINT16_MAX) { + uint16_t y = x; + kputc_('S', &str); kputsn_(&y, 2, &str); + } else { + uint32_t y = x; + kputc_('I', &str); kputsn_(&y, 4, &str); + } + } + } else if (type == 'f') { + float x; + x = strtod(q, &q); + kputc_('f', &str); kputsn_(&x, 4, &str); + } else if (type == 'd') { + double x; + x = strtod(q, &q); + kputc_('d', &str); kputsn_(&x, 8, &str); + } else if (type == 'Z' || type == 'H') { + kputc_(type, &str);kputsn_(q, p - q, &str); // note that this include the trailing NULL + } else if (type == 'B') { + int32_t n; + char *r; + _parse_err(p - q - 1 < 3, "incomplete B-typed aux field"); + type = *q++; // q points to the first ',' following the typing byte + for (r = q, n = 0; *r; ++r) + if (*r == ',') ++n; + kputc_('B', &str); kputc_(type, &str); kputsn_(&n, 4, &str); + // FIXME: to evaluate which is faster: a) aligned array and then memmove(); b) unaligned array; c) kputsn_() + if (type == 'c') while (q + 1 < p) { int8_t x = strtol(q + 1, &q, 0); kputc_(x, &str); } + else if (type == 'C') while (q + 1 < p) { uint8_t x = strtoul(q + 1, &q, 0); kputc_(x, &str); } + else if (type == 's') while (q + 1 < p) { int16_t x = strtol(q + 1, &q, 0); kputsn_(&x, 2, &str); } + else if (type == 'S') while (q + 1 < p) { uint16_t x = strtoul(q + 1, &q, 0); kputsn_(&x, 2, &str); } + else if (type == 'i') while (q + 1 < p) { int32_t x = strtol(q + 1, &q, 0); kputsn_(&x, 4, &str); } + else if (type == 'I') while (q + 1 < p) { uint32_t x = strtoul(q + 1, &q, 0); kputsn_(&x, 4, &str); } + else if (type == 'f') while (q + 1 < p) { float x = strtod(q + 1, &q); kputsn_(&x, 4, &str); } + else _parse_err(1, "unrecognized type"); + } else _parse_err(1, "unrecognized type"); + } + b->data = (uint8_t*)str.s; b->l_data = str.l; b->m_data = str.m; + return 0; + +#undef _parse_warn +#undef _parse_err +#undef _get_mem +#undef _read_token_aux +#undef _read_token +err_ret: + b->data = (uint8_t*)str.s; b->l_data = str.l; b->m_data = str.m; + return -2; +} + +int sam_read1(htsFile *fp, bam_hdr_t *h, bam1_t *b) +{ + switch (fp->format.format) { + case bam: { + int r = bam_read1(fp->fp.bgzf, b); + if (r >= 0) { + if (b->core.tid >= h->n_targets || b->core.tid < -1 || + b->core.mtid >= h->n_targets || b->core.mtid < -1) + return -3; + } + return r; + } + + case cram: + return cram_get_bam_seq(fp->fp.cram, &b); + + case sam: { + int ret; +err_recover: + if (fp->line.l == 0) { + ret = hts_getline(fp, KS_SEP_LINE, &fp->line); + if (ret < 0) return -1; + } + ret = sam_parse1(&fp->line, h, b); + fp->line.l = 0; + if (ret < 0) { + if (hts_verbose >= 1) + fprintf(stderr, "[W::%s] parse error at line %lld\n", __func__, (long long)fp->lineno); + if (h->ignore_sam_err) goto err_recover; + } + return ret; + } + + default: + abort(); + } +} + +int sam_format1(const bam_hdr_t *h, const bam1_t *b, kstring_t *str) +{ + int i; + uint8_t *s; + const bam1_core_t *c = &b->core; + + str->l = 0; + kputsn(bam_get_qname(b), c->l_qname-1, str); kputc('\t', str); // query name + kputw(c->flag, str); kputc('\t', str); // flag + if (c->tid >= 0) { // chr + kputs(h->target_name[c->tid] , str); + kputc('\t', str); + } else kputsn("*\t", 2, str); + kputw(c->pos + 1, str); kputc('\t', str); // pos + kputw(c->qual, str); kputc('\t', str); // qual + if (c->n_cigar) { // cigar + uint32_t *cigar = bam_get_cigar(b); + for (i = 0; i < c->n_cigar; ++i) { + kputw(bam_cigar_oplen(cigar[i]), str); + kputc(bam_cigar_opchr(cigar[i]), str); + } + } else kputc('*', str); + kputc('\t', str); + if (c->mtid < 0) kputsn("*\t", 2, str); // mate chr + else if (c->mtid == c->tid) kputsn("=\t", 2, str); + else { + kputs(h->target_name[c->mtid], str); + kputc('\t', str); + } + kputw(c->mpos + 1, str); kputc('\t', str); // mate pos + kputw(c->isize, str); kputc('\t', str); // template len + if (c->l_qseq) { // seq and qual + uint8_t *s = bam_get_seq(b); + for (i = 0; i < c->l_qseq; ++i) kputc("=ACMGRSVTWYHKDBN"[bam_seqi(s, i)], str); + kputc('\t', str); + s = bam_get_qual(b); + if (s[0] == 0xff) kputc('*', str); + else for (i = 0; i < c->l_qseq; ++i) kputc(s[i] + 33, str); + } else kputsn("*\t*", 3, str); + s = bam_get_aux(b); // aux + while (s+4 <= b->data + b->l_data) { + uint8_t type, key[2]; + key[0] = s[0]; key[1] = s[1]; + s += 2; type = *s++; + kputc('\t', str); kputsn((char*)key, 2, str); kputc(':', str); + if (type == 'A') { + kputsn("A:", 2, str); + kputc(*s, str); + ++s; + } else if (type == 'C') { + kputsn("i:", 2, str); + kputw(*s, str); + ++s; + } else if (type == 'c') { + kputsn("i:", 2, str); + kputw(*(int8_t*)s, str); + ++s; + } else if (type == 'S') { + if (s+2 <= b->data + b->l_data) { + kputsn("i:", 2, str); + kputw(*(uint16_t*)s, str); + s += 2; + } else return -1; + } else if (type == 's') { + if (s+2 <= b->data + b->l_data) { + kputsn("i:", 2, str); + kputw(*(int16_t*)s, str); + s += 2; + } else return -1; + } else if (type == 'I') { + if (s+4 <= b->data + b->l_data) { + kputsn("i:", 2, str); + kputuw(*(uint32_t*)s, str); + s += 4; + } else return -1; + } else if (type == 'i') { + if (s+4 <= b->data + b->l_data) { + kputsn("i:", 2, str); + kputw(*(int32_t*)s, str); + s += 4; + } else return -1; + } else if (type == 'f') { + if (s+4 <= b->data + b->l_data) { + ksprintf(str, "f:%g", *(float*)s); + s += 4; + } else return -1; + + } else if (type == 'd') { + if (s+8 <= b->data + b->l_data) { + ksprintf(str, "d:%g", *(double*)s); + s += 8; + } else return -1; + } else if (type == 'Z' || type == 'H') { + kputc(type, str); kputc(':', str); + while (s < b->data + b->l_data && *s) kputc(*s++, str); + if (s >= b->data + b->l_data) + return -1; + ++s; + } else if (type == 'B') { + uint8_t sub_type = *(s++); + int32_t n; + memcpy(&n, s, 4); + s += 4; // no point to the start of the array + if (s + n >= b->data + b->l_data) + return -1; + kputsn("B:", 2, str); kputc(sub_type, str); // write the typing + for (i = 0; i < n; ++i) { // FIXME: for better performance, put the loop after "if" + kputc(',', str); + if ('c' == sub_type) { kputw(*(int8_t*)s, str); ++s; } + else if ('C' == sub_type) { kputw(*(uint8_t*)s, str); ++s; } + else if ('s' == sub_type) { kputw(*(int16_t*)s, str); s += 2; } + else if ('S' == sub_type) { kputw(*(uint16_t*)s, str); s += 2; } + else if ('i' == sub_type) { kputw(*(int32_t*)s, str); s += 4; } + else if ('I' == sub_type) { kputuw(*(uint32_t*)s, str); s += 4; } + else if ('f' == sub_type) { ksprintf(str, "%g", *(float*)s); s += 4; } + } + } + } + return str->l; +} + +int sam_write1(htsFile *fp, const bam_hdr_t *h, const bam1_t *b) +{ + switch (fp->format.format) { + case binary_format: + fp->format.category = sequence_data; + fp->format.format = bam; + /* fall-through */ + case bam: + return bam_write1(fp->fp.bgzf, b); + + case cram: + return cram_put_bam_seq(fp->fp.cram, (bam1_t *)b); + + case text_format: + fp->format.category = sequence_data; + fp->format.format = sam; + /* fall-through */ + case sam: + if (sam_format1(h, b, &fp->line) < 0) return -1; + kputc('\n', &fp->line); + if ( hwrite(fp->fp.hfile, fp->line.s, fp->line.l) != fp->line.l ) return -1; + return fp->line.l; + + default: + abort(); + } +} + +/************************ + *** Auxiliary fields *** + ************************/ + +void bam_aux_append(bam1_t *b, const char tag[2], char type, int len, uint8_t *data) +{ + int ori_len = b->l_data; + b->l_data += 3 + len; + if (b->m_data < b->l_data) { + b->m_data = b->l_data; + kroundup32(b->m_data); + b->data = (uint8_t*)realloc(b->data, b->m_data); + } + b->data[ori_len] = tag[0]; b->data[ori_len + 1] = tag[1]; + b->data[ori_len + 2] = type; + memcpy(b->data + ori_len + 3, data, len); +} + +static inline uint8_t *skip_aux(uint8_t *s) +{ + int size = aux_type2size(*s); ++s; // skip type + uint32_t n; + switch (size) { + case 'Z': + case 'H': + while (*s) ++s; + return s + 1; + case 'B': + size = aux_type2size(*s); ++s; + memcpy(&n, s, 4); s += 4; + return s + size * n; + case 0: + abort(); + break; + default: + return s + size; + } +} + +uint8_t *bam_aux_get(const bam1_t *b, const char tag[2]) +{ + uint8_t *s; + int y = tag[0]<<8 | tag[1]; + s = bam_get_aux(b); + while (s < b->data + b->l_data) { + int x = (int)s[0]<<8 | s[1]; + s += 2; + if (x == y) return s; + s = skip_aux(s); + } + return 0; +} +// s MUST BE returned by bam_aux_get() +int bam_aux_del(bam1_t *b, uint8_t *s) +{ + uint8_t *p, *aux; + int l_aux = bam_get_l_aux(b); + aux = bam_get_aux(b); + p = s - 2; + s = skip_aux(s); + memmove(p, s, l_aux - (s - aux)); + b->l_data -= s - p; + return 0; +} + +int32_t bam_aux2i(const uint8_t *s) +{ + int type; + type = *s++; + if (type == 'c') return (int32_t)*(int8_t*)s; + else if (type == 'C') return (int32_t)*(uint8_t*)s; + else if (type == 's') return (int32_t)*(int16_t*)s; + else if (type == 'S') return (int32_t)*(uint16_t*)s; + else if (type == 'i' || type == 'I') return *(int32_t*)s; + else return 0; +} + +double bam_aux2f(const uint8_t *s) +{ + int type; + type = *s++; + if (type == 'd') return *(double*)s; + else if (type == 'f') return *(float*)s; + else return 0.0; +} + +char bam_aux2A(const uint8_t *s) +{ + int type; + type = *s++; + if (type == 'A') return *(char*)s; + else return 0; +} + +char *bam_aux2Z(const uint8_t *s) +{ + int type; + type = *s++; + if (type == 'Z' || type == 'H') return (char*)s; + else return 0; +} + +int sam_open_mode(char *mode, const char *fn, const char *format) +{ + // TODO Parse "bam5" etc for compression level + if (format == NULL) { + // Try to pick a format based on the filename extension + const char *ext = fn? strrchr(fn, '.') : NULL; + if (ext == NULL || strchr(ext, '/')) return -1; + return sam_open_mode(mode, fn, ext+1); + } + else if (strcmp(format, "bam") == 0) strcpy(mode, "b"); + else if (strcmp(format, "cram") == 0) strcpy(mode, "c"); + else if (strcmp(format, "sam") == 0) strcpy(mode, ""); + else return -1; + + return 0; +} + +#define STRNCMP(a,b,n) (strncasecmp((a),(b),(n)) || strlen(a)!=(n)) +int bam_str2flag(const char *str) +{ + char *end, *beg = (char*) str; + long int flag = strtol(str, &end, 0); + if ( end!=str ) return flag; // the conversion was successful + flag = 0; + while ( *str ) + { + end = beg; + while ( *end && *end!=',' ) end++; + if ( !STRNCMP("PAIRED",beg,end-beg) ) flag |= BAM_FPAIRED; + else if ( !STRNCMP("PROPER_PAIR",beg,end-beg) ) flag |= BAM_FPROPER_PAIR; + else if ( !STRNCMP("UNMAP",beg,end-beg) ) flag |= BAM_FUNMAP; + else if ( !STRNCMP("MUNMAP",beg,end-beg) ) flag |= BAM_FMUNMAP; + else if ( !STRNCMP("REVERSE",beg,end-beg) ) flag |= BAM_FREVERSE; + else if ( !STRNCMP("MREVERSE",beg,end-beg) ) flag |= BAM_FMREVERSE; + else if ( !STRNCMP("READ1",beg,end-beg) ) flag |= BAM_FREAD1; + else if ( !STRNCMP("READ2",beg,end-beg) ) flag |= BAM_FREAD2; + else if ( !STRNCMP("SECONDARY",beg,end-beg) ) flag |= BAM_FSECONDARY; + else if ( !STRNCMP("QCFAIL",beg,end-beg) ) flag |= BAM_FQCFAIL; + else if ( !STRNCMP("DUP",beg,end-beg) ) flag |= BAM_FDUP; + else if ( !STRNCMP("SUPPLEMENTARY",beg,end-beg) ) flag |= BAM_FSUPPLEMENTARY; + else return -1; + if ( !*end ) break; + beg = end + 1; + } + return flag; +} + +char *bam_flag2str(int flag) +{ + kstring_t str = {0,0,0}; + if ( flag&BAM_FPAIRED ) ksprintf(&str,"%s%s", str.l?",":"","PAIRED"); + if ( flag&BAM_FPROPER_PAIR ) ksprintf(&str,"%s%s", str.l?",":"","PROPER_PAIR"); + if ( flag&BAM_FUNMAP ) ksprintf(&str,"%s%s", str.l?",":"","UNMAP"); + if ( flag&BAM_FMUNMAP ) ksprintf(&str,"%s%s", str.l?",":"","MUNMAP"); + if ( flag&BAM_FREVERSE ) ksprintf(&str,"%s%s", str.l?",":"","REVERSE"); + if ( flag&BAM_FMREVERSE ) ksprintf(&str,"%s%s", str.l?",":"","MREVERSE"); + if ( flag&BAM_FREAD1 ) ksprintf(&str,"%s%s", str.l?",":"","READ1"); + if ( flag&BAM_FREAD2 ) ksprintf(&str,"%s%s", str.l?",":"","READ2"); + if ( flag&BAM_FSECONDARY ) ksprintf(&str,"%s%s", str.l?",":"","SECONDARY"); + if ( flag&BAM_FQCFAIL ) ksprintf(&str,"%s%s", str.l?",":"","QCFAIL"); + if ( flag&BAM_FDUP ) ksprintf(&str,"%s%s", str.l?",":"","DUP"); + if ( flag&BAM_FSUPPLEMENTARY ) ksprintf(&str,"%s%s", str.l?",":"","SUPPLEMENTARY"); + if ( str.l == 0 ) kputsn("", 0, &str); + return str.s; +} + + +/************************** + *** Pileup and Mpileup *** + **************************/ + +#if !defined(BAM_NO_PILEUP) + +#include <assert.h> + +/******************* + *** Memory pool *** + *******************/ + +typedef struct { + int k, x, y, end; +} cstate_t; + +static cstate_t g_cstate_null = { -1, 0, 0, 0 }; + +typedef struct __linkbuf_t { + bam1_t b; + int32_t beg, end; + cstate_t s; + struct __linkbuf_t *next; +} lbnode_t; + +typedef struct { + int cnt, n, max; + lbnode_t **buf; +} mempool_t; + +static mempool_t *mp_init(void) +{ + mempool_t *mp; + mp = (mempool_t*)calloc(1, sizeof(mempool_t)); + return mp; +} +static void mp_destroy(mempool_t *mp) +{ + int k; + for (k = 0; k < mp->n; ++k) { + free(mp->buf[k]->b.data); + free(mp->buf[k]); + } + free(mp->buf); + free(mp); +} +static inline lbnode_t *mp_alloc(mempool_t *mp) +{ + ++mp->cnt; + if (mp->n == 0) return (lbnode_t*)calloc(1, sizeof(lbnode_t)); + else return mp->buf[--mp->n]; +} +static inline void mp_free(mempool_t *mp, lbnode_t *p) +{ + --mp->cnt; p->next = 0; // clear lbnode_t::next here + if (mp->n == mp->max) { + mp->max = mp->max? mp->max<<1 : 256; + mp->buf = (lbnode_t**)realloc(mp->buf, sizeof(lbnode_t*) * mp->max); + } + mp->buf[mp->n++] = p; +} + +/********************** + *** CIGAR resolver *** + **********************/ + +/* s->k: the index of the CIGAR operator that has just been processed. + s->x: the reference coordinate of the start of s->k + s->y: the query coordiante of the start of s->k + */ +static inline int resolve_cigar2(bam_pileup1_t *p, int32_t pos, cstate_t *s) +{ +#define _cop(c) ((c)&BAM_CIGAR_MASK) +#define _cln(c) ((c)>>BAM_CIGAR_SHIFT) + + bam1_t *b = p->b; + bam1_core_t *c = &b->core; + uint32_t *cigar = bam_get_cigar(b); + int k; + // determine the current CIGAR operation +// fprintf(stderr, "%s\tpos=%d\tend=%d\t(%d,%d,%d)\n", bam_get_qname(b), pos, s->end, s->k, s->x, s->y); + if (s->k == -1) { // never processed + if (c->n_cigar == 1) { // just one operation, save a loop + if (_cop(cigar[0]) == BAM_CMATCH || _cop(cigar[0]) == BAM_CEQUAL || _cop(cigar[0]) == BAM_CDIFF) s->k = 0, s->x = c->pos, s->y = 0; + } else { // find the first match or deletion + for (k = 0, s->x = c->pos, s->y = 0; k < c->n_cigar; ++k) { + int op = _cop(cigar[k]); + int l = _cln(cigar[k]); + if (op == BAM_CMATCH || op == BAM_CDEL || op == BAM_CEQUAL || op == BAM_CDIFF) break; + else if (op == BAM_CREF_SKIP) s->x += l; + else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) s->y += l; + } + assert(k < c->n_cigar); + s->k = k; + } + } else { // the read has been processed before + int op, l = _cln(cigar[s->k]); + if (pos - s->x >= l) { // jump to the next operation + assert(s->k < c->n_cigar); // otherwise a bug: this function should not be called in this case + op = _cop(cigar[s->k+1]); + if (op == BAM_CMATCH || op == BAM_CDEL || op == BAM_CREF_SKIP || op == BAM_CEQUAL || op == BAM_CDIFF) { // jump to the next without a loop + if (_cop(cigar[s->k]) == BAM_CMATCH|| _cop(cigar[s->k]) == BAM_CEQUAL || _cop(cigar[s->k]) == BAM_CDIFF) s->y += l; + s->x += l; + ++s->k; + } else { // find the next M/D/N/=/X + if (_cop(cigar[s->k]) == BAM_CMATCH|| _cop(cigar[s->k]) == BAM_CEQUAL || _cop(cigar[s->k]) == BAM_CDIFF) s->y += l; + s->x += l; + for (k = s->k + 1; k < c->n_cigar; ++k) { + op = _cop(cigar[k]), l = _cln(cigar[k]); + if (op == BAM_CMATCH || op == BAM_CDEL || op == BAM_CREF_SKIP || op == BAM_CEQUAL || op == BAM_CDIFF) break; + else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) s->y += l; + } + s->k = k; + } + assert(s->k < c->n_cigar); // otherwise a bug + } // else, do nothing + } + { // collect pileup information + int op, l; + op = _cop(cigar[s->k]); l = _cln(cigar[s->k]); + p->is_del = p->indel = p->is_refskip = 0; + if (s->x + l - 1 == pos && s->k + 1 < c->n_cigar) { // peek the next operation + int op2 = _cop(cigar[s->k+1]); + int l2 = _cln(cigar[s->k+1]); + if (op2 == BAM_CDEL) p->indel = -(int)l2; + else if (op2 == BAM_CINS) p->indel = l2; + else if (op2 == BAM_CPAD && s->k + 2 < c->n_cigar) { // no working for adjacent padding + int l3 = 0; + for (k = s->k + 2; k < c->n_cigar; ++k) { + op2 = _cop(cigar[k]); l2 = _cln(cigar[k]); + if (op2 == BAM_CINS) l3 += l2; + else if (op2 == BAM_CDEL || op2 == BAM_CMATCH || op2 == BAM_CREF_SKIP || op2 == BAM_CEQUAL || op2 == BAM_CDIFF) break; + } + if (l3 > 0) p->indel = l3; + } + } + if (op == BAM_CMATCH || op == BAM_CEQUAL || op == BAM_CDIFF) { + p->qpos = s->y + (pos - s->x); + } else if (op == BAM_CDEL || op == BAM_CREF_SKIP) { + p->is_del = 1; p->qpos = s->y; // FIXME: distinguish D and N!!!!! + p->is_refskip = (op == BAM_CREF_SKIP); + } // cannot be other operations; otherwise a bug + p->is_head = (pos == c->pos); p->is_tail = (pos == s->end); + } + return 1; +} + +/*********************** + *** Pileup iterator *** + ***********************/ + +// Dictionary of overlapping reads +KHASH_MAP_INIT_STR(olap_hash, lbnode_t *) +typedef khash_t(olap_hash) olap_hash_t; + +struct __bam_plp_t { + mempool_t *mp; + lbnode_t *head, *tail, *dummy; + int32_t tid, pos, max_tid, max_pos; + int is_eof, max_plp, error, maxcnt; + uint64_t id; + bam_pileup1_t *plp; + // for the "auto" interface only + bam1_t *b; + bam_plp_auto_f func; + void *data; + olap_hash_t *overlaps; +}; + +bam_plp_t bam_plp_init(bam_plp_auto_f func, void *data) +{ + bam_plp_t iter; + iter = (bam_plp_t)calloc(1, sizeof(struct __bam_plp_t)); + iter->mp = mp_init(); + iter->head = iter->tail = mp_alloc(iter->mp); + iter->dummy = mp_alloc(iter->mp); + iter->max_tid = iter->max_pos = -1; + iter->maxcnt = 8000; + if (func) { + iter->func = func; + iter->data = data; + iter->b = bam_init1(); + } + return iter; +} + +void bam_plp_init_overlaps(bam_plp_t iter) +{ + iter->overlaps = kh_init(olap_hash); // hash for tweaking quality of bases in overlapping reads +} + +void bam_plp_destroy(bam_plp_t iter) +{ + if ( iter->overlaps ) kh_destroy(olap_hash, iter->overlaps); + mp_free(iter->mp, iter->dummy); + mp_free(iter->mp, iter->head); + if (iter->mp->cnt != 0) + fprintf(stderr, "[bam_plp_destroy] memory leak: %d. Continue anyway.\n", iter->mp->cnt); + mp_destroy(iter->mp); + if (iter->b) bam_destroy1(iter->b); + free(iter->plp); + free(iter); +} + + +//--------------------------------- +//--- Tweak overlapping reads +//--------------------------------- + +/** + * cigar_iref2iseq_set() - find the first CMATCH setting the ref and the read index + * cigar_iref2iseq_next() - get the next CMATCH base + * @cigar: pointer to current cigar block (rw) + * @cigar_max: pointer just beyond the last cigar block + * @icig: position within the current cigar block (rw) + * @iseq: position in the sequence (rw) + * @iref: position with respect to the beginning of the read (iref_pos - b->core.pos) (rw) + * + * Returns BAM_CMATCH or -1 when there is no more cigar to process or the requested position is not covered. + */ +static inline int cigar_iref2iseq_set(uint32_t **cigar, uint32_t *cigar_max, int *icig, int *iseq, int *iref) +{ + int pos = *iref; + if ( pos < 0 ) return -1; + *icig = 0; + *iseq = 0; + *iref = 0; + while ( *cigar<cigar_max ) + { + int cig = (**cigar) & BAM_CIGAR_MASK; + int ncig = (**cigar) >> BAM_CIGAR_SHIFT; + + if ( cig==BAM_CSOFT_CLIP ) { (*cigar)++; *iseq += ncig; *icig = 0; continue; } + if ( cig==BAM_CHARD_CLIP || cig==BAM_CPAD ) { (*cigar)++; *icig = 0; continue; } + if ( cig==BAM_CMATCH || cig==BAM_CEQUAL || cig==BAM_CDIFF ) + { + pos -= ncig; + if ( pos < 0 ) { *icig = ncig + pos; *iseq += *icig; *iref += *icig; return BAM_CMATCH; } + (*cigar)++; *iseq += ncig; *icig = 0; *iref += ncig; + continue; + } + if ( cig==BAM_CINS ) { (*cigar)++; *iseq += ncig; *icig = 0; continue; } + if ( cig==BAM_CDEL || cig==BAM_CREF_SKIP ) + { + pos -= ncig; + if ( pos<0 ) pos = 0; + (*cigar)++; *icig = 0; *iref += ncig; + continue; + } + fprintf(stderr,"todo: cigar %d\n", cig); + assert(0); + } + *iseq = -1; + return -1; +} +static inline int cigar_iref2iseq_next(uint32_t **cigar, uint32_t *cigar_max, int *icig, int *iseq, int *iref) +{ + while ( *cigar < cigar_max ) + { + int cig = (**cigar) & BAM_CIGAR_MASK; + int ncig = (**cigar) >> BAM_CIGAR_SHIFT; + + if ( cig==BAM_CMATCH || cig==BAM_CEQUAL || cig==BAM_CDIFF ) + { + if ( *icig >= ncig - 1 ) { *icig = 0; (*cigar)++; continue; } + (*iseq)++; (*icig)++; (*iref)++; + return BAM_CMATCH; + } + if ( cig==BAM_CDEL || cig==BAM_CREF_SKIP ) { (*cigar)++; (*iref) += ncig; *icig = 0; continue; } + if ( cig==BAM_CINS ) { (*cigar)++; *iseq += ncig; *icig = 0; continue; } + if ( cig==BAM_CSOFT_CLIP ) { (*cigar)++; *iseq += ncig; *icig = 0; continue; } + if ( cig==BAM_CHARD_CLIP || cig==BAM_CPAD ) { (*cigar)++; *icig = 0; continue; } + fprintf(stderr,"todo: cigar %d\n", cig); + assert(0); + } + *iseq = -1; + *iref = -1; + return -1; +} + +static void tweak_overlap_quality(bam1_t *a, bam1_t *b) +{ + uint32_t *a_cigar = bam_get_cigar(a), *a_cigar_max = a_cigar + a->core.n_cigar; + uint32_t *b_cigar = bam_get_cigar(b), *b_cigar_max = b_cigar + b->core.n_cigar; + int a_icig = 0, a_iseq = 0; + int b_icig = 0, b_iseq = 0; + uint8_t *a_qual = bam_get_qual(a), *b_qual = bam_get_qual(b); + uint8_t *a_seq = bam_get_seq(a), *b_seq = bam_get_seq(b); + + int iref = b->core.pos; + int a_iref = iref - a->core.pos; + int b_iref = iref - b->core.pos; + int a_ret = cigar_iref2iseq_set(&a_cigar, a_cigar_max, &a_icig, &a_iseq, &a_iref); + if ( a_ret<0 ) return; // no overlap + int b_ret = cigar_iref2iseq_set(&b_cigar, b_cigar_max, &b_icig, &b_iseq, &b_iref); + if ( b_ret<0 ) return; // no overlap + + #if DBG + fprintf(stderr,"tweak %s n_cigar=%d %d .. %d-%d vs %d-%d\n", bam_get_qname(a), a->core.n_cigar, b->core.n_cigar, + a->core.pos+1,a->core.pos+bam_cigar2rlen(a->core.n_cigar,bam_get_cigar(a)), b->core.pos+1, b->core.pos+bam_cigar2rlen(b->core.n_cigar,bam_get_cigar(b))); + #endif + + while ( 1 ) + { + // Increment reference position + while ( a_iref>=0 && a_iref < iref - a->core.pos ) + a_ret = cigar_iref2iseq_next(&a_cigar, a_cigar_max, &a_icig, &a_iseq, &a_iref); + if ( a_ret<0 ) break; // done + if ( iref < a_iref + a->core.pos ) iref = a_iref + a->core.pos; + + while ( b_iref>=0 && b_iref < iref - b->core.pos ) + b_ret = cigar_iref2iseq_next(&b_cigar, b_cigar_max, &b_icig, &b_iseq, &b_iref); + if ( b_ret<0 ) break; // done + if ( iref < b_iref + b->core.pos ) iref = b_iref + b->core.pos; + + iref++; + if ( a_iref+a->core.pos != b_iref+b->core.pos ) continue; // only CMATCH positions, don't know what to do with indels + + if ( bam_seqi(a_seq,a_iseq) == bam_seqi(b_seq,b_iseq) ) + { + #if DBG + fprintf(stderr,"%c",seq_nt16_str[bam_seqi(a_seq,a_iseq)]); + #endif + // we are very confident about this base + int qual = a_qual[a_iseq] + b_qual[b_iseq]; + a_qual[a_iseq] = qual>200 ? 200 : qual; + b_qual[b_iseq] = 0; + } + else + { + if ( a_qual[a_iseq] >= b_qual[b_iseq] ) + { + #if DBG + fprintf(stderr,"[%c/%c]",seq_nt16_str[bam_seqi(a_seq,a_iseq)],tolower(seq_nt16_str[bam_seqi(b_seq,b_iseq)])); + #endif + a_qual[a_iseq] = 0.8 * a_qual[a_iseq]; // not so confident about a_qual anymore given the mismatch + b_qual[b_iseq] = 0; + } + else + { + #if DBG + fprintf(stderr,"[%c/%c]",tolower(seq_nt16_str[bam_seqi(a_seq,a_iseq)]),seq_nt16_str[bam_seqi(b_seq,b_iseq)]); + #endif + b_qual[b_iseq] = 0.8 * b_qual[b_iseq]; + a_qual[a_iseq] = 0; + } + } + } + #if DBG + fprintf(stderr,"\n"); + #endif +} + +// Fix overlapping reads. Simple soft-clipping did not give good results. +// Lowering qualities of unwanted bases is more selective and works better. +// +static void overlap_push(bam_plp_t iter, lbnode_t *node) +{ + if ( !iter->overlaps ) return; + + // mapped mates and paired reads only + if ( node->b.core.flag&BAM_FMUNMAP || !(node->b.core.flag&BAM_FPROPER_PAIR) ) return; + + // no overlap possible, unless some wild cigar + if ( abs(node->b.core.isize) >= 2*node->b.core.l_qseq ) return; + + khiter_t kitr = kh_get(olap_hash, iter->overlaps, bam_get_qname(&node->b)); + if ( kitr==kh_end(iter->overlaps) ) + { + int ret; + kitr = kh_put(olap_hash, iter->overlaps, bam_get_qname(&node->b), &ret); + kh_value(iter->overlaps, kitr) = node; + } + else + { + lbnode_t *a = kh_value(iter->overlaps, kitr); + tweak_overlap_quality(&a->b, &node->b); + kh_del(olap_hash, iter->overlaps, kitr); + assert(a->end-1 == a->s.end); + a->end = a->b.core.pos + bam_cigar2rlen(a->b.core.n_cigar, bam_get_cigar(&a->b)); + a->s.end = a->end - 1; + } +} + +static void overlap_remove(bam_plp_t iter, const bam1_t *b) +{ + if ( !iter->overlaps ) return; + + khiter_t kitr; + if ( b ) + { + kitr = kh_get(olap_hash, iter->overlaps, bam_get_qname(b)); + if ( kitr!=kh_end(iter->overlaps) ) + kh_del(olap_hash, iter->overlaps, kitr); + } + else + { + // remove all + for (kitr = kh_begin(iter->overlaps); kitr<kh_end(iter->overlaps); kitr++) + if ( kh_exist(iter->overlaps, kitr) ) kh_del(olap_hash, iter->overlaps, kitr); + } +} + + + +// Prepares next pileup position in bam records collected by bam_plp_auto -> user func -> bam_plp_push. Returns +// pointer to the piled records if next position is ready or NULL if there is not enough records in the +// buffer yet (the current position is still the maximum position across all buffered reads). +const bam_pileup1_t *bam_plp_next(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp) +{ + if (iter->error) { *_n_plp = -1; return 0; } + *_n_plp = 0; + if (iter->is_eof && iter->head->next == 0) return 0; + while (iter->is_eof || iter->max_tid > iter->tid || (iter->max_tid == iter->tid && iter->max_pos > iter->pos)) { + int n_plp = 0; + lbnode_t *p, *q; + // write iter->plp at iter->pos + iter->dummy->next = iter->head; + for (p = iter->head, q = iter->dummy; p->next; q = p, p = p->next) { + if (p->b.core.tid < iter->tid || (p->b.core.tid == iter->tid && p->end <= iter->pos)) { // then remove + overlap_remove(iter, &p->b); + q->next = p->next; mp_free(iter->mp, p); p = q; + } else if (p->b.core.tid == iter->tid && p->beg <= iter->pos) { // here: p->end > pos; then add to pileup + if (n_plp == iter->max_plp) { // then double the capacity + iter->max_plp = iter->max_plp? iter->max_plp<<1 : 256; + iter->plp = (bam_pileup1_t*)realloc(iter->plp, sizeof(bam_pileup1_t) * iter->max_plp); + } + iter->plp[n_plp].b = &p->b; + if (resolve_cigar2(iter->plp + n_plp, iter->pos, &p->s)) ++n_plp; // actually always true... + } + } + iter->head = iter->dummy->next; // dummy->next may be changed + *_n_plp = n_plp; *_tid = iter->tid; *_pos = iter->pos; + // update iter->tid and iter->pos + if (iter->head->next) { + if (iter->tid > iter->head->b.core.tid) { + fprintf(stderr, "[%s] unsorted input. Pileup aborts.\n", __func__); + iter->error = 1; + *_n_plp = -1; + return 0; + } + } + if (iter->tid < iter->head->b.core.tid) { // come to a new reference sequence + iter->tid = iter->head->b.core.tid; iter->pos = iter->head->beg; // jump to the next reference + } else if (iter->pos < iter->head->beg) { // here: tid == head->b.core.tid + iter->pos = iter->head->beg; // jump to the next position + } else ++iter->pos; // scan contiguously + // return + if (n_plp) return iter->plp; + if (iter->is_eof && iter->head->next == 0) break; + } + return 0; +} + +int bam_plp_push(bam_plp_t iter, const bam1_t *b) +{ + if (iter->error) return -1; + if (b) { + if (b->core.tid < 0) { overlap_remove(iter, b); return 0; } + // Skip only unmapped reads here, any additional filtering must be done in iter->func + if (b->core.flag & BAM_FUNMAP) { overlap_remove(iter, b); return 0; } + if (iter->tid == b->core.tid && iter->pos == b->core.pos && iter->mp->cnt > iter->maxcnt) + { + overlap_remove(iter, b); + return 0; + } + bam_copy1(&iter->tail->b, b); + overlap_push(iter, iter->tail); +#ifndef BAM_NO_ID + iter->tail->b.id = iter->id++; +#endif + iter->tail->beg = b->core.pos; + iter->tail->end = b->core.pos + bam_cigar2rlen(b->core.n_cigar, bam_get_cigar(b)); + iter->tail->s = g_cstate_null; iter->tail->s.end = iter->tail->end - 1; // initialize cstate_t + if (b->core.tid < iter->max_tid) { + fprintf(stderr, "[bam_pileup_core] the input is not sorted (chromosomes out of order)\n"); + iter->error = 1; + return -1; + } + if ((b->core.tid == iter->max_tid) && (iter->tail->beg < iter->max_pos)) { + fprintf(stderr, "[bam_pileup_core] the input is not sorted (reads out of order)\n"); + iter->error = 1; + return -1; + } + iter->max_tid = b->core.tid; iter->max_pos = iter->tail->beg; + if (iter->tail->end > iter->pos || iter->tail->b.core.tid > iter->tid) { + iter->tail->next = mp_alloc(iter->mp); + iter->tail = iter->tail->next; + } + } else iter->is_eof = 1; + return 0; +} + +const bam_pileup1_t *bam_plp_auto(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp) +{ + const bam_pileup1_t *plp; + if (iter->func == 0 || iter->error) { *_n_plp = -1; return 0; } + if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp; + else { // no pileup line can be obtained; read alignments + *_n_plp = 0; + if (iter->is_eof) return 0; + int ret; + while ( (ret=iter->func(iter->data, iter->b)) >= 0) { + if (bam_plp_push(iter, iter->b) < 0) { + *_n_plp = -1; + return 0; + } + if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp; + // otherwise no pileup line can be returned; read the next alignment. + } + if ( ret < -1 ) { iter->error = ret; *_n_plp = -1; return 0; } + bam_plp_push(iter, 0); + if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp; + return 0; + } +} + +void bam_plp_reset(bam_plp_t iter) +{ + lbnode_t *p, *q; + iter->max_tid = iter->max_pos = -1; + iter->tid = iter->pos = 0; + iter->is_eof = 0; + for (p = iter->head; p->next;) { + overlap_remove(iter, NULL); + q = p->next; + mp_free(iter->mp, p); + p = q; + } + iter->head = iter->tail; +} + +void bam_plp_set_maxcnt(bam_plp_t iter, int maxcnt) +{ + iter->maxcnt = maxcnt; +} + +/************************ + *** Mpileup iterator *** + ************************/ + +struct __bam_mplp_t { + int n; + uint64_t min, *pos; + bam_plp_t *iter; + int *n_plp; + const bam_pileup1_t **plp; +}; + +bam_mplp_t bam_mplp_init(int n, bam_plp_auto_f func, void **data) +{ + int i; + bam_mplp_t iter; + iter = (bam_mplp_t)calloc(1, sizeof(struct __bam_mplp_t)); + iter->pos = (uint64_t*)calloc(n, sizeof(uint64_t)); + iter->n_plp = (int*)calloc(n, sizeof(int)); + iter->plp = (const bam_pileup1_t**)calloc(n, sizeof(bam_pileup1_t*)); + iter->iter = (bam_plp_t*)calloc(n, sizeof(bam_plp_t)); + iter->n = n; + iter->min = (uint64_t)-1; + for (i = 0; i < n; ++i) { + iter->iter[i] = bam_plp_init(func, data[i]); + iter->pos[i] = iter->min; + } + return iter; +} + +void bam_mplp_init_overlaps(bam_mplp_t iter) +{ + int i; + for (i = 0; i < iter->n; ++i) + bam_plp_init_overlaps(iter->iter[i]); +} + +void bam_mplp_set_maxcnt(bam_mplp_t iter, int maxcnt) +{ + int i; + for (i = 0; i < iter->n; ++i) + iter->iter[i]->maxcnt = maxcnt; +} + +void bam_mplp_destroy(bam_mplp_t iter) +{ + int i; + for (i = 0; i < iter->n; ++i) bam_plp_destroy(iter->iter[i]); + free(iter->iter); free(iter->pos); free(iter->n_plp); free(iter->plp); + free(iter); +} + +int bam_mplp_auto(bam_mplp_t iter, int *_tid, int *_pos, int *n_plp, const bam_pileup1_t **plp) +{ + int i, ret = 0; + uint64_t new_min = (uint64_t)-1; + for (i = 0; i < iter->n; ++i) { + if (iter->pos[i] == iter->min) { + int tid, pos; + iter->plp[i] = bam_plp_auto(iter->iter[i], &tid, &pos, &iter->n_plp[i]); + if ( iter->iter[i]->error ) return -1; + iter->pos[i] = iter->plp[i] ? (uint64_t)tid<<32 | pos : 0; + } + if (iter->plp[i] && iter->pos[i] < new_min) new_min = iter->pos[i]; + } + iter->min = new_min; + if (new_min == (uint64_t)-1) return 0; + *_tid = new_min>>32; *_pos = (uint32_t)new_min; + for (i = 0; i < iter->n; ++i) { + if (iter->pos[i] == iter->min) { // FIXME: valgrind reports "uninitialised value(s) at this line" + n_plp[i] = iter->n_plp[i], plp[i] = iter->plp[i]; + ++ret; + } else n_plp[i] = 0, plp[i] = 0; + } + return ret; +} + +#endif // ~!defined(BAM_NO_PILEUP)
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/synced_bcf_reader.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1257 @@ +/* synced_bcf_reader.c -- stream through multiple VCF files. + + Copyright (C) 2012-2014 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> +#include <unistd.h> +#include <string.h> +#include <limits.h> +#include <errno.h> +#include <ctype.h> +#include <sys/stat.h> +#include "htslib/synced_bcf_reader.h" +#include "htslib/kseq.h" +#include "htslib/khash_str2int.h" + +#define MAX_CSI_COOR 0x7fffffff // maximum indexable coordinate of .csi + +typedef struct +{ + uint32_t start, end; +} +region1_t; + +typedef struct _region_t +{ + region1_t *regs; + int nregs, mregs, creg; +} +region_t; + +static void _regions_add(bcf_sr_regions_t *reg, const char *chr, int start, int end); +static bcf_sr_regions_t *_regions_init_string(const char *str); +static int _regions_match_alleles(bcf_sr_regions_t *reg, int als_idx, bcf1_t *rec); + +char *bcf_sr_strerror(int errnum) +{ + switch (errnum) + { + case open_failed: + return strerror(errno); break; + case not_bgzf: + return "not compressed with bgzip"; break; + case idx_load_failed: + return "could not load index"; break; + case file_type_error: + return "unknown file type"; break; + case api_usage_error: + return "API usage error"; break; + case header_error: + return "could not parse header"; break; + default: return ""; + } +} + +static int *init_filters(bcf_hdr_t *hdr, const char *filters, int *nfilters) +{ + kstring_t str = {0,0,0}; + const char *tmp = filters, *prev = filters; + int nout = 0, *out = NULL; + while ( 1 ) + { + if ( *tmp==',' || !*tmp ) + { + out = (int*) realloc(out, (nout+1)*sizeof(int)); + if ( tmp-prev==1 && *prev=='.' ) + out[nout] = -1; + else + { + str.l = 0; + kputsn(prev, tmp-prev, &str); + out[nout] = bcf_hdr_id2int(hdr, BCF_DT_ID, str.s); + } + nout++; + if ( !*tmp ) break; + prev = tmp+1; + } + tmp++; + } + if ( str.m ) free(str.s); + *nfilters = nout; + return out; +} + +int bcf_sr_set_regions(bcf_srs_t *readers, const char *regions, int is_file) +{ + assert( !readers->regions ); + if ( readers->nreaders ) + { + fprintf(stderr,"[%s:%d %s] Error: bcf_sr_set_regions() must be called before bcf_sr_add_reader()\n", __FILE__,__LINE__,__FUNCTION__); + return -1; + } + readers->regions = bcf_sr_regions_init(regions,is_file,0,1,-2); + if ( !readers->regions ) return -1; + readers->explicit_regs = 1; + readers->require_index = 1; + return 0; +} +int bcf_sr_set_targets(bcf_srs_t *readers, const char *targets, int is_file, int alleles) +{ + assert( !readers->targets ); + if ( targets[0]=='^' ) + { + readers->targets_exclude = 1; + targets++; + } + readers->targets = bcf_sr_regions_init(targets,is_file,0,1,-2); + if ( !readers->targets ) return -1; + readers->targets_als = alleles; + return 0; +} + +int bcf_sr_add_reader(bcf_srs_t *files, const char *fname) +{ + htsFile* file_ptr = hts_open(fname, "r"); + if ( ! file_ptr ) { + files->errnum = open_failed; + return 0; + } + + files->has_line = (int*) realloc(files->has_line, sizeof(int)*(files->nreaders+1)); + files->has_line[files->nreaders] = 0; + files->readers = (bcf_sr_t*) realloc(files->readers, sizeof(bcf_sr_t)*(files->nreaders+1)); + bcf_sr_t *reader = &files->readers[files->nreaders++]; + memset(reader,0,sizeof(bcf_sr_t)); + + reader->file = file_ptr; + + files->errnum = 0; + + if ( files->require_index ) + { + if ( reader->file->format.format==vcf ) + { + if ( reader->file->format.compression!=bgzf ) + { + files->errnum = not_bgzf; + return 0; + } + + reader->tbx_idx = tbx_index_load(fname); + if ( !reader->tbx_idx ) + { + files->errnum = idx_load_failed; + return 0; + } + + reader->header = bcf_hdr_read(reader->file); + } + else if ( reader->file->format.format==bcf ) + { + if ( reader->file->format.compression!=bgzf ) + { + files->errnum = not_bgzf; + return 0; + } + + reader->header = bcf_hdr_read(reader->file); + + reader->bcf_idx = bcf_index_load(fname); + if ( !reader->bcf_idx ) + { + files->errnum = idx_load_failed; + return 0; + } + } + else + { + files->errnum = file_type_error; + return 0; + } + } + else + { + if ( reader->file->format.format==bcf || reader->file->format.format==vcf ) + { + reader->header = bcf_hdr_read(reader->file); + } + else + { + files->errnum = file_type_error; + return 0; + } + files->streaming = 1; + } + if ( files->streaming && files->nreaders>1 ) + { + files->errnum = api_usage_error; + fprintf(stderr,"[%s:%d %s] Error: %d readers, yet require_index not set\n", __FILE__,__LINE__,__FUNCTION__,files->nreaders); + return 0; + } + if ( files->streaming && files->regions ) + { + files->errnum = api_usage_error; + fprintf(stderr,"[%s:%d %s] Error: cannot tabix-jump in streaming mode\n", __FILE__,__LINE__,__FUNCTION__); + return 0; + } + if ( !reader->header ) + { + files->errnum = header_error; + return 0; + } + + reader->fname = fname; + if ( files->apply_filters ) + reader->filter_ids = init_filters(reader->header, files->apply_filters, &reader->nfilter_ids); + + // Update list of chromosomes + if ( !files->explicit_regs && !files->streaming ) + { + int n,i; + const char **names = reader->tbx_idx ? tbx_seqnames(reader->tbx_idx, &n) : bcf_hdr_seqnames(reader->header, &n); + for (i=0; i<n; i++) + { + if ( !files->regions ) + files->regions = _regions_init_string(names[i]); + else + _regions_add(files->regions, names[i], -1, -1); + } + free(names); + } + + return 1; +} + +bcf_srs_t *bcf_sr_init(void) +{ + bcf_srs_t *files = (bcf_srs_t*) calloc(1,sizeof(bcf_srs_t)); + return files; +} + +static void bcf_sr_destroy1(bcf_sr_t *reader) +{ + if ( reader->tbx_idx ) tbx_destroy(reader->tbx_idx); + if ( reader->bcf_idx ) hts_idx_destroy(reader->bcf_idx); + bcf_hdr_destroy(reader->header); + hts_close(reader->file); + if ( reader->itr ) tbx_itr_destroy(reader->itr); + int j; + for (j=0; j<reader->mbuffer; j++) + bcf_destroy1(reader->buffer[j]); + free(reader->buffer); + free(reader->samples); + free(reader->filter_ids); +} +void bcf_sr_destroy(bcf_srs_t *files) +{ + int i; + for (i=0; i<files->nreaders; i++) + bcf_sr_destroy1(&files->readers[i]); + free(files->has_line); + free(files->readers); + for (i=0; i<files->n_smpl; i++) free(files->samples[i]); + free(files->samples); + if (files->targets) bcf_sr_regions_destroy(files->targets); + if (files->regions) bcf_sr_regions_destroy(files->regions); + if ( files->tmps.m ) free(files->tmps.s); + free(files); +} + +void bcf_sr_remove_reader(bcf_srs_t *files, int i) +{ + assert( !files->samples ); // not ready for this yet + bcf_sr_destroy1(&files->readers[i]); + if ( i+1 < files->nreaders ) + { + memmove(&files->readers[i], &files->readers[i+1], (files->nreaders-i-1)*sizeof(bcf_sr_t)); + memmove(&files->has_line[i], &files->has_line[i+1], (files->nreaders-i-1)*sizeof(int)); + } + files->nreaders--; +} + + +/* + Removes duplicate records from the buffer. The meaning of "duplicate" is + controlled by the $collapse variable, which can cause that from multiple + <indel|snp|any> lines only the first is considered and the rest is ignored. + The removal is done by setting the redundant lines' positions to -1 and + moving these lines at the end of the buffer. + */ +static void collapse_buffer(bcf_srs_t *files, bcf_sr_t *reader) +{ + int irec,jrec, has_snp=0, has_indel=0, has_any=0; + for (irec=1; irec<=reader->nbuffer; irec++) + { + bcf1_t *line = reader->buffer[irec]; + if ( line->pos != reader->buffer[1]->pos ) break; + if ( files->collapse&COLLAPSE_ANY ) + { + if ( !has_any ) has_any = 1; + else line->pos = -1; + } + int line_type = bcf_get_variant_types(line); + if ( files->collapse&COLLAPSE_SNPS && line_type&(VCF_SNP|VCF_MNP) ) + { + if ( !has_snp ) has_snp = 1; + else line->pos = -1; + } + if ( files->collapse&COLLAPSE_INDELS && line_type&VCF_INDEL ) + { + if ( !has_indel ) has_indel = 1; + else line->pos = -1; + } + } + bcf1_t *tmp; + irec = jrec = 1; + while ( irec<=reader->nbuffer && jrec<=reader->nbuffer ) + { + if ( reader->buffer[irec]->pos != -1 ) { irec++; continue; } + if ( jrec<=irec ) jrec = irec+1; + while ( jrec<=reader->nbuffer && reader->buffer[jrec]->pos==-1 ) jrec++; + if ( jrec<=reader->nbuffer ) + { + tmp = reader->buffer[irec]; reader->buffer[irec] = reader->buffer[jrec]; reader->buffer[jrec] = tmp; + } + } + reader->nbuffer = irec - 1; +} + +void debug_buffer(FILE *fp, bcf_sr_t *reader) +{ + int j; + for (j=0; j<=reader->nbuffer; j++) + { + bcf1_t *line = reader->buffer[j]; + fprintf(fp,"%s%s\t%s:%d\t%s ", reader->fname,j==0?"*":"",reader->header->id[BCF_DT_CTG][line->rid].key,line->pos+1,line->n_allele?line->d.allele[0]:""); + int k; + for (k=1; k<line->n_allele; k++) fprintf(fp," %s", line->d.allele[k]); + fprintf(fp,"\n"); + } +} + +void debug_buffers(FILE *fp, bcf_srs_t *files) +{ + int i; + for (i=0; i<files->nreaders; i++) + { + fprintf(fp, "has_line: %d\t%s\n", bcf_sr_has_line(files,i),files->readers[i].fname); + debug_buffer(fp, &files->readers[i]); + } + fprintf(fp,"\n"); +} + +static inline int has_filter(bcf_sr_t *reader, bcf1_t *line) +{ + int i, j; + if ( !line->d.n_flt ) + { + for (j=0; j<reader->nfilter_ids; j++) + if ( reader->filter_ids[j]<0 ) return 1; + return 0; + } + for (i=0; i<line->d.n_flt; i++) + { + for (j=0; j<reader->nfilter_ids; j++) + if ( line->d.flt[i]==reader->filter_ids[j] ) return 1; + } + return 0; +} + +static int _reader_seek(bcf_sr_t *reader, const char *seq, int start, int end) +{ + if ( end>=MAX_CSI_COOR ) + { + fprintf(stderr,"The coordinate is out of csi index limit: %d\n", end+1); + exit(1); + } + if ( reader->itr ) + { + hts_itr_destroy(reader->itr); + reader->itr = NULL; + } + reader->nbuffer = 0; + if ( reader->tbx_idx ) + { + int tid = tbx_name2id(reader->tbx_idx, seq); + if ( tid==-1 ) return -1; // the sequence not present in this file + reader->itr = tbx_itr_queryi(reader->tbx_idx,tid,start,end+1); + } + else + { + int tid = bcf_hdr_name2id(reader->header, seq); + if ( tid==-1 ) return -1; // the sequence not present in this file + reader->itr = bcf_itr_queryi(reader->bcf_idx,tid,start,end+1); + } + assert(reader->itr); + return 0; +} + +/* + * _readers_next_region() - jumps to next region if necessary + * Returns 0 on success or -1 when there are no more regions left + */ +static int _readers_next_region(bcf_srs_t *files) +{ + // Need to open new chromosome? Check number of lines in all readers' buffers + int i, eos = 0; + for (i=0; i<files->nreaders; i++) + if ( !files->readers[i].itr && !files->readers[i].nbuffer ) eos++; + + if ( eos!=files->nreaders ) + { + // Some of the readers still has buffered lines + return 0; + } + + // No lines in the buffer, need to open new region or quit + if ( bcf_sr_regions_next(files->regions)<0 ) return -1; + + for (i=0; i<files->nreaders; i++) + _reader_seek(&files->readers[i],files->regions->seq_names[files->regions->iseq],files->regions->start,files->regions->end); + + return 0; +} + +/* + * _reader_fill_buffer() - buffers all records with the same coordinate + */ +static void _reader_fill_buffer(bcf_srs_t *files, bcf_sr_t *reader) +{ + // Return if the buffer is full: the coordinate of the last buffered record differs + if ( reader->nbuffer && reader->buffer[reader->nbuffer]->pos != reader->buffer[1]->pos ) return; + + // No iterator (sequence not present in this file) and not streaming + if ( !reader->itr && !files->streaming ) return; + + // Fill the buffer with records starting at the same position + int i, ret = 0; + while (1) + { + if ( reader->nbuffer+1 >= reader->mbuffer ) + { + // Increase buffer size + reader->mbuffer += 8; + reader->buffer = (bcf1_t**) realloc(reader->buffer, sizeof(bcf1_t*)*reader->mbuffer); + for (i=8; i>0; i--) // initialize + { + reader->buffer[reader->mbuffer-i] = bcf_init1(); + reader->buffer[reader->mbuffer-i]->max_unpack = files->max_unpack; + reader->buffer[reader->mbuffer-i]->pos = -1; // for rare cases when VCF starts from 1 + } + } + if ( files->streaming ) + { + if ( reader->file->format.format==vcf ) + { + if ( (ret=hts_getline(reader->file, KS_SEP_LINE, &files->tmps)) < 0 ) break; // no more lines + int ret = vcf_parse1(&files->tmps, reader->header, reader->buffer[reader->nbuffer+1]); + if ( ret<0 ) break; + } + else if ( reader->file->format.format==bcf ) + { + if ( (ret=bcf_read1(reader->file, reader->header, reader->buffer[reader->nbuffer+1])) < 0 ) break; // no more lines + } + else + { + fprintf(stderr,"[%s:%d %s] fixme: not ready for this\n", __FILE__,__LINE__,__FUNCTION__); + exit(1); + } + } + else if ( reader->tbx_idx ) + { + if ( (ret=tbx_itr_next(reader->file, reader->tbx_idx, reader->itr, &files->tmps)) < 0 ) break; // no more lines + vcf_parse1(&files->tmps, reader->header, reader->buffer[reader->nbuffer+1]); + } + else + { + if ( (ret=bcf_itr_next(reader->file, reader->itr, reader->buffer[reader->nbuffer+1])) < 0 ) break; // no more lines + bcf_subset_format(reader->header,reader->buffer[reader->nbuffer+1]); + } + + // apply filter + if ( !reader->nfilter_ids ) + bcf_unpack(reader->buffer[reader->nbuffer+1], BCF_UN_STR); + else + { + bcf_unpack(reader->buffer[reader->nbuffer+1], BCF_UN_STR|BCF_UN_FLT); + if ( !has_filter(reader, reader->buffer[reader->nbuffer+1]) ) continue; + } + reader->nbuffer++; + + if ( reader->buffer[reader->nbuffer]->pos != reader->buffer[1]->pos ) break; // the buffer is full + } + if ( ret<0 ) + { + // done for this region + tbx_itr_destroy(reader->itr); + reader->itr = NULL; + } + if ( files->collapse && reader->nbuffer>=2 && reader->buffer[1]->pos==reader->buffer[2]->pos ) + collapse_buffer(files, reader); +} + +/* + * _readers_shift_buffer() - removes the first line and all subsequent lines with the same position + */ +static void _reader_shift_buffer(bcf_sr_t *reader) +{ + int i; + for (i=2; i<=reader->nbuffer; i++) + if ( reader->buffer[i]->pos!=reader->buffer[1]->pos ) break; + if ( i<=reader->nbuffer ) + { + // A record with a different position follows, swap it. Because of the reader's logic, + // only one such line can be present. + bcf1_t *tmp = reader->buffer[1]; reader->buffer[1] = reader->buffer[i]; reader->buffer[i] = tmp; + reader->nbuffer = 1; + } + else + reader->nbuffer = 0; // no other line +} + +/* + * _reader_match_alleles() - from multiple buffered lines selects the one which + * corresponds best to the template line. The logic is controlled by COLLAPSE_* + * Returns 0 on success or -1 when no good matching line is found. + */ +static int _reader_match_alleles(bcf_srs_t *files, bcf_sr_t *reader, bcf1_t *tmpl) +{ + int i, irec = -1; + + // if no template given, use the first available record + if ( !tmpl ) + irec = 1; + else + { + int tmpl_type = bcf_get_variant_types(tmpl); + for (i=1; i<=reader->nbuffer; i++) + { + bcf1_t *line = reader->buffer[i]; + if ( line->pos != reader->buffer[1]->pos ) break; // done with this reader + + // Easiest case: matching by position only + if ( files->collapse&COLLAPSE_ANY ) { irec=i; break; } + + int line_type = bcf_get_variant_types(line); + + // No matter what the alleles are, as long as they are both SNPs + if ( files->collapse&COLLAPSE_SNPS && tmpl_type&VCF_SNP && line_type&VCF_SNP ) { irec=i; break; } + // ... or indels + if ( files->collapse&COLLAPSE_INDELS && tmpl_type&VCF_INDEL && line_type&VCF_INDEL ) { irec=i; break; } + + // More thorough checking: REFs must match + if ( tmpl->rlen != line->rlen ) continue; // different length + if ( strcmp(tmpl->d.allele[0], line->d.allele[0]) ) continue; // the strings do not match + + int ial,jal; + if ( files->collapse==COLLAPSE_NONE ) + { + // Exact match, all alleles must be identical + if ( tmpl->n_allele!=line->n_allele ) continue; // different number of alleles, skip + + int nmatch = 1; // REF has been already checked + for (ial=1; ial<tmpl->n_allele; ial++) + { + for (jal=1; jal<line->n_allele; jal++) + if ( !strcmp(tmpl->d.allele[ial], line->d.allele[jal]) ) { nmatch++; break; } + } + if ( nmatch==tmpl->n_allele ) { irec=i; break; } // found: exact match + continue; + } + + if ( line->n_allele==1 && tmpl->n_allele==1 ) { irec=i; break; } // both sites are non-variant + + // COLLAPSE_SOME: at least some ALTs must match + for (ial=1; ial<tmpl->n_allele; ial++) + { + for (jal=1; jal<line->n_allele; jal++) + if ( !strcmp(tmpl->d.allele[ial], line->d.allele[jal]) ) { irec=i; break; } + if ( irec>=1 ) break; + } + if ( irec>=1 ) break; + } + if ( irec==-1 ) return -1; // no matching line was found + } + + // Set the selected line (irec) as active: set it to buffer[0], move the remaining lines forward + // and put the old bcf1_t record at the end. + bcf1_t *tmp = reader->buffer[0]; + reader->buffer[0] = reader->buffer[irec]; + for (i=irec+1; i<=reader->nbuffer; i++) reader->buffer[i-1] = reader->buffer[i]; + reader->buffer[ reader->nbuffer ] = tmp; + reader->nbuffer--; + + return 0; +} + +int _reader_next_line(bcf_srs_t *files) +{ + int i, min_pos = INT_MAX; + + // Loop until next suitable line is found or all readers have finished + while ( 1 ) + { + // Get all readers ready for the next region. + if ( files->regions && _readers_next_region(files)<0 ) break; + + // Fill buffers + const char *chr = NULL; + for (i=0; i<files->nreaders; i++) + { + _reader_fill_buffer(files, &files->readers[i]); + + // Update the minimum coordinate + if ( !files->readers[i].nbuffer ) continue; + if ( min_pos > files->readers[i].buffer[1]->pos ) + { + min_pos = files->readers[i].buffer[1]->pos; + chr = bcf_seqname(files->readers[i].header, files->readers[i].buffer[1]); + } + } + if ( min_pos==INT_MAX ) + { + if ( !files->regions ) break; + continue; + } + + // Skip this position if not present in targets + if ( files->targets ) + { + int ret = bcf_sr_regions_overlap(files->targets, chr, min_pos, min_pos); + if ( (!files->targets_exclude && ret<0) || (files->targets_exclude && !ret) ) + { + // Remove all lines with this position from the buffer + for (i=0; i<files->nreaders; i++) + if ( files->readers[i].nbuffer && files->readers[i].buffer[1]->pos==min_pos ) + _reader_shift_buffer(&files->readers[i]); + min_pos = INT_MAX; + continue; + } + } + + break; // done: min_pos is set + } + + // There can be records with duplicate positions. Set the active line intelligently so that + // the alleles match. + int nret = 0; // number of readers sharing the position + bcf1_t *first = NULL; // record which will be used for allele matching + for (i=0; i<files->nreaders; i++) + { + files->has_line[i] = 0; + + // Skip readers with no records at this position + if ( !files->readers[i].nbuffer || files->readers[i].buffer[1]->pos!=min_pos ) continue; + + // Until now buffer[0] of all reader was empty and the lines started at buffer[1]. + // Now lines which are ready to be output will be moved to buffer[0]. + if ( _reader_match_alleles(files, &files->readers[i], first) < 0 ) continue; + if ( !first ) first = files->readers[i].buffer[0]; + + nret++; + files->has_line[i] = 1; + } + return nret; +} + +int bcf_sr_next_line(bcf_srs_t *files) +{ + if ( !files->targets_als ) + return _reader_next_line(files); + + while (1) + { + int i, ret = _reader_next_line(files); + if ( !ret ) return ret; + + for (i=0; i<files->nreaders; i++) + if ( files->has_line[i] ) break; + + if ( _regions_match_alleles(files->targets, files->targets_als-1, files->readers[i].buffer[0]) ) return ret; + + // Check if there are more duplicate lines in the buffers. If not, return this line as if it + // matched the targets, even if there is a type mismatch + for (i=0; i<files->nreaders; i++) + { + if ( !files->has_line[i] ) continue; + if ( files->readers[i].nbuffer==0 || files->readers[i].buffer[1]->pos!=files->readers[i].buffer[0]->pos ) continue; + break; + } + if ( i==files->nreaders ) return ret; // no more lines left, output even if target alleles are not of the same type + } +} + +static void bcf_sr_seek_start(bcf_srs_t *readers) +{ + bcf_sr_regions_t *reg = readers->regions; + int i; + for (i=0; i<reg->nseqs; i++) + reg->regs[i].creg = -1; + reg->iseq = 0; +} + + +int bcf_sr_seek(bcf_srs_t *readers, const char *seq, int pos) +{ + if ( !seq && !pos ) + { + // seek to start + bcf_sr_seek_start(readers); + return 0; + } + + bcf_sr_regions_overlap(readers->regions, seq, pos, pos); + int i, nret = 0; + for (i=0; i<readers->nreaders; i++) + { + nret += _reader_seek(&readers->readers[i],seq,pos,MAX_CSI_COOR-1); + } + return nret; +} + +int bcf_sr_set_samples(bcf_srs_t *files, const char *fname, int is_file) +{ + int i, j, nsmpl, free_smpl = 0; + char **smpl = NULL; + + void *exclude = (fname[0]=='^') ? khash_str2int_init() : NULL; + if ( exclude || strcmp("-",fname) ) // "-" stands for all samples + { + smpl = hts_readlist(fname, is_file, &nsmpl); + if ( !smpl ) + { + fprintf(stderr,"Could not read the file: \"%s\"\n", fname); + return 0; + } + if ( exclude ) + { + for (i=0; i<nsmpl; i++) + khash_str2int_inc(exclude, smpl[i]); + } + free_smpl = 1; + } + if ( !smpl ) + { + smpl = files->readers[0].header->samples; // intersection of all samples + nsmpl = bcf_hdr_nsamples(files->readers[0].header); + } + + files->samples = NULL; + files->n_smpl = 0; + for (i=0; i<nsmpl; i++) + { + if ( exclude && khash_str2int_has_key(exclude,smpl[i]) ) continue; + + int n_isec = 0; + for (j=0; j<files->nreaders; j++) + { + if ( bcf_hdr_id2int(files->readers[j].header, BCF_DT_SAMPLE, smpl[i])<0 ) break; + n_isec++; + } + if ( n_isec!=files->nreaders ) + { + fprintf(stderr,"Warning: The sample \"%s\" was not found in %s, skipping\n", smpl[i], files->readers[n_isec].fname); + continue; + } + + files->samples = (char**) realloc(files->samples, (files->n_smpl+1)*sizeof(const char*)); + files->samples[files->n_smpl++] = strdup(smpl[i]); + } + + if ( exclude ) khash_str2int_destroy(exclude); + if ( free_smpl ) + { + for (i=0; i<nsmpl; i++) free(smpl[i]); + free(smpl); + } + + if ( !files->n_smpl ) + { + if ( files->nreaders>1 ) + fprintf(stderr,"No samples in common.\n"); + return 0; + } + for (i=0; i<files->nreaders; i++) + { + bcf_sr_t *reader = &files->readers[i]; + reader->samples = (int*) malloc(sizeof(int)*files->n_smpl); + reader->n_smpl = files->n_smpl; + for (j=0; j<files->n_smpl; j++) + reader->samples[j] = bcf_hdr_id2int(reader->header, BCF_DT_SAMPLE, files->samples[j]); + } + return 1; +} + +// Add a new region into a list sorted by start,end. On input the coordinates +// are 1-based, stored 0-based, inclusive. +static void _regions_add(bcf_sr_regions_t *reg, const char *chr, int start, int end) +{ + if ( start==-1 && end==-1 ) + { + start = 0; end = MAX_CSI_COOR-1; + } + else + { + start--; end--; // store 0-based coordinates + } + + if ( !reg->seq_hash ) + reg->seq_hash = khash_str2int_init(); + + int iseq; + if ( khash_str2int_get(reg->seq_hash, chr, &iseq)<0 ) + { + // the chromosome block does not exist + iseq = reg->nseqs++; + reg->seq_names = (char**) realloc(reg->seq_names,sizeof(char*)*reg->nseqs); + reg->regs = (region_t*) realloc(reg->regs,sizeof(region_t)*reg->nseqs); + memset(®->regs[reg->nseqs-1],0,sizeof(region_t)); + reg->seq_names[iseq] = strdup(chr); + reg->regs[iseq].creg = -1; + khash_str2int_set(reg->seq_hash,reg->seq_names[iseq],iseq); + } + + region_t *creg = ®->regs[iseq]; + + // the regions may not be sorted on input: binary search + int i, min = 0, max = creg->nregs - 1; + while ( min<=max ) + { + i = (max+min)/2; + if ( start < creg->regs[i].start ) max = i - 1; + else if ( start > creg->regs[i].start ) min = i + 1; + else break; + } + if ( min>max || creg->regs[i].start!=start || creg->regs[i].end!=end ) + { + // no such region, insert a new one just after max + hts_expand(region1_t,creg->nregs+1,creg->mregs,creg->regs); + if ( ++max < creg->nregs ) + memmove(&creg->regs[max+1],&creg->regs[max],(creg->nregs - max)*sizeof(region1_t)); + creg->regs[max].start = start; + creg->regs[max].end = end; + creg->nregs++; + } +} + +// File name or a list of genomic locations. If file name, NULL is returned. +static bcf_sr_regions_t *_regions_init_string(const char *str) +{ + bcf_sr_regions_t *reg = (bcf_sr_regions_t *) calloc(1, sizeof(bcf_sr_regions_t)); + reg->start = reg->end = -1; + reg->prev_start = reg->prev_seq = -1; + + kstring_t tmp = {0,0,0}; + const char *sp = str, *ep = str; + int from, to; + while ( 1 ) + { + while ( *ep && *ep!=',' && *ep!=':' ) ep++; + tmp.l = 0; + kputsn(sp,ep-sp,&tmp); + if ( *ep==':' ) + { + sp = ep+1; + from = strtol(sp,(char**)&ep,10); + if ( sp==ep ) + { + fprintf(stderr,"[%s:%d %s] Could not parse the region(s): %s\n", __FILE__,__LINE__,__FUNCTION__,str); + free(reg); free(tmp.s); return NULL; + } + if ( !*ep || *ep==',' ) + { + _regions_add(reg, tmp.s, from, from); + sp = ep; + continue; + } + if ( *ep!='-' ) + { + fprintf(stderr,"[%s:%d %s] Could not parse the region(s): %s\n", __FILE__,__LINE__,__FUNCTION__,str); + free(reg); free(tmp.s); return NULL; + } + ep++; + sp = ep; + to = strtol(sp,(char**)&ep,10); + if ( *ep && *ep!=',' ) + { + fprintf(stderr,"[%s:%d %s] Could not parse the region(s): %s\n", __FILE__,__LINE__,__FUNCTION__,str); + free(reg); free(tmp.s); return NULL; + } + if ( sp==ep ) to = MAX_CSI_COOR-1; + _regions_add(reg, tmp.s, from, to); + if ( !*ep ) break; + sp = ep; + } + else + { + if ( tmp.l ) _regions_add(reg, tmp.s, -1, -1); + if ( !*ep ) break; + sp = ++ep; + } + } + free(tmp.s); + return reg; +} + +// ichr,ifrom,ito are 0-based; +// returns -1 on error, 0 if the line is a comment line, 1 on success +static int _regions_parse_line(char *line, int ichr,int ifrom,int ito, char **chr,char **chr_end,int *from,int *to) +{ + *chr_end = NULL; + + if ( line[0]=='#' ) return 0; + + int k,l; // index of the start and end column of the tab-delimited file + if ( ifrom <= ito ) + k = ifrom, l = ito; + else + l = ifrom, k = ito; + + int i; + char *se = line, *ss = NULL; // start and end + char *tmp; + for (i=0; i<=k && *se; i++) + { + ss = i==0 ? se++ : ++se; + while (*se && *se!='\t') se++; + } + if ( i<=k ) return -1; + if ( k==l ) + { + *from = *to = strtol(ss, &tmp, 10); + if ( tmp==ss ) return -1; + } + else + { + if ( k==ifrom ) + *from = strtol(ss, &tmp, 10); + else + *to = strtol(ss, &tmp, 10); + if ( ss==tmp ) return -1; + + for (i=k; i<l && *se; i++) + { + ss = ++se; + while (*se && *se!='\t') se++; + } + if ( i<l ) return -1; + if ( k==ifrom ) + *to = strtol(ss, &tmp, 10); + else + *from = strtol(ss, &tmp, 10); + if ( ss==tmp ) return -1; + } + + ss = se = line; + for (i=0; i<=ichr && *se; i++) + { + if ( i>0 ) ss = ++se; + while (*se && *se!='\t') se++; + } + if ( i<=ichr ) return -1; + *chr_end = se; + *chr = ss; + return 1; +} + +bcf_sr_regions_t *bcf_sr_regions_init(const char *regions, int is_file, int ichr, int ifrom, int ito) +{ + bcf_sr_regions_t *reg; + if ( !is_file ) return _regions_init_string(regions); + + reg = (bcf_sr_regions_t *) calloc(1, sizeof(bcf_sr_regions_t)); + reg->start = reg->end = -1; + reg->prev_start = reg->prev_seq = -1; + + reg->file = hts_open(regions, "rb"); + if ( !reg->file ) + { + fprintf(stderr,"[%s:%d %s] Could not open file: %s\n", __FILE__,__LINE__,__FUNCTION__,regions); + free(reg); + return NULL; + } + + reg->tbx = tbx_index_load(regions); + if ( !reg->tbx ) + { + int len = strlen(regions); + int is_bed = strcasecmp(".bed",regions+len-4) ? 0 : 1; + if ( !is_bed && !strcasecmp(".bed.gz",regions+len-7) ) is_bed = 1; + + if ( reg->file->format.format==vcf ) ito = 1; + + // read the whole file, tabix index is not present + while ( hts_getline(reg->file, KS_SEP_LINE, ®->line) > 0 ) + { + char *chr, *chr_end; + int from, to, ret; + ret = _regions_parse_line(reg->line.s, ichr,ifrom,abs(ito), &chr,&chr_end,&from,&to); + if ( ret < 0 ) + { + if ( ito<0 ) + ret = _regions_parse_line(reg->line.s, ichr,ifrom,ifrom, &chr,&chr_end,&from,&to); + if ( ret<0 ) + { + fprintf(stderr,"[%s:%d] Could not parse the file %s, using the columns %d,%d[,%d]\n", __FILE__,__LINE__,regions,ichr+1,ifrom+1,ito+1); + hts_close(reg->file); reg->file = NULL; free(reg); + return NULL; + } + } + if ( !ret ) continue; + if ( is_bed ) from++; + *chr_end = 0; + _regions_add(reg, chr, from, to); + *chr_end = '\t'; + } + hts_close(reg->file); reg->file = NULL; + if ( !reg->nseqs ) { free(reg); return NULL; } + return reg; + } + + reg->seq_names = (char**) tbx_seqnames(reg->tbx, ®->nseqs); + if ( !reg->seq_hash ) + reg->seq_hash = khash_str2int_init(); + int i; + for (i=0; i<reg->nseqs; i++) + { + khash_str2int_set(reg->seq_hash,reg->seq_names[i],i); + } + reg->fname = strdup(regions); + reg->is_bin = 1; + return reg; +} + +void bcf_sr_regions_destroy(bcf_sr_regions_t *reg) +{ + int i; + free(reg->fname); + if ( reg->itr ) tbx_itr_destroy(reg->itr); + if ( reg->tbx ) tbx_destroy(reg->tbx); + if ( reg->file ) hts_close(reg->file); + if ( reg->als ) free(reg->als); + if ( reg->als_str.s ) free(reg->als_str.s); + free(reg->line.s); + if ( reg->regs ) + { + // free only in-memory names, tbx names are const + for (i=0; i<reg->nseqs; i++) + { + free(reg->seq_names[i]); + free(reg->regs[i].regs); + } + } + free(reg->regs); + free(reg->seq_names); + khash_str2int_destroy(reg->seq_hash); + free(reg); +} + +int bcf_sr_regions_seek(bcf_sr_regions_t *reg, const char *seq) +{ + reg->iseq = reg->start = reg->end = -1; + if ( khash_str2int_get(reg->seq_hash, seq, ®->iseq) < 0 ) return -1; // sequence seq not in regions + + // using in-memory regions + if ( reg->regs ) + { + reg->regs[reg->iseq].creg = -1; + return 0; + } + + // reading regions from tabix + if ( reg->itr ) tbx_itr_destroy(reg->itr); + reg->itr = tbx_itr_querys(reg->tbx, seq); + if ( reg->itr ) return 0; + + return -1; +} + +int bcf_sr_regions_next(bcf_sr_regions_t *reg) +{ + if ( reg->iseq<0 ) return -1; + reg->start = reg->end = -1; + reg->nals = 0; + + // using in-memory regions + if ( reg->regs ) + { + while ( reg->iseq < reg->nseqs ) + { + reg->regs[reg->iseq].creg++; + if ( reg->regs[reg->iseq].creg < reg->regs[reg->iseq].nregs ) break; + reg->iseq++; + } + if ( reg->iseq >= reg->nseqs ) { reg->iseq = -1; return -1; } // no more regions left + region1_t *creg = ®->regs[reg->iseq].regs[reg->regs[reg->iseq].creg]; + reg->start = creg->start; + reg->end = creg->end; + return 0; + } + + // reading from tabix + char *chr, *chr_end; + int ichr = 0, ifrom = 1, ito = 2, is_bed = 0, from, to; + if ( reg->tbx ) + { + ichr = reg->tbx->conf.sc-1; + ifrom = reg->tbx->conf.bc-1; + ito = reg->tbx->conf.ec-1; + if ( ito<0 ) ito = ifrom; + is_bed = reg->tbx->conf.preset==TBX_UCSC ? 1 : 0; + } + + int ret = 0; + while ( !ret ) + { + if ( reg->itr ) + { + // tabix index present, reading a chromosome block + ret = tbx_itr_next(reg->file, reg->tbx, reg->itr, ®->line); + if ( ret<0 ) { reg->iseq = -1; return -1; } + } + else + { + if ( reg->is_bin ) + { + // Waited for seek which never came. Reopen in text mode and stream + // through the regions, otherwise hts_getline would fail + hts_close(reg->file); + reg->file = hts_open(reg->fname, "r"); + if ( !reg->file ) + { + fprintf(stderr,"[%s:%d %s] Could not open file: %s\n", __FILE__,__LINE__,__FUNCTION__,reg->fname); + reg->file = NULL; + bcf_sr_regions_destroy(reg); + return -1; + } + reg->is_bin = 0; + } + + // tabix index absent, reading the whole file + ret = hts_getline(reg->file, KS_SEP_LINE, ®->line); + if ( ret<0 ) { reg->iseq = -1; return -1; } + } + ret = _regions_parse_line(reg->line.s, ichr,ifrom,ito, &chr,&chr_end,&from,&to); + if ( ret<0 ) + { + fprintf(stderr,"[%s:%d] Could not parse the file %s, using the columns %d,%d,%d\n", __FILE__,__LINE__,reg->fname,ichr+1,ifrom+1,ito+1); + return -1; + } + } + if ( is_bed ) from++; + + *chr_end = 0; + if ( khash_str2int_get(reg->seq_hash, chr, ®->iseq)<0 ) + { + fprintf(stderr,"Broken tabix index? The sequence \"%s\" not in dictionary [%s]\n", chr,reg->line.s); + exit(1); + } + *chr_end = '\t'; + + reg->start = from - 1; + reg->end = to - 1; + return 0; +} + +static int _regions_match_alleles(bcf_sr_regions_t *reg, int als_idx, bcf1_t *rec) +{ + int i = 0, max_len = 0; + if ( !reg->nals ) + { + char *ss = reg->line.s; + while ( i<als_idx && *ss ) + { + if ( *ss=='\t' ) i++; + ss++; + } + char *se = ss; + reg->nals = 1; + while ( *se && *se!='\t' ) + { + if ( *se==',' ) reg->nals++; + se++; + } + ks_resize(®->als_str, se-ss+1+reg->nals); + reg->als_str.l = 0; + hts_expand(char*,reg->nals,reg->mals,reg->als); + reg->nals = 0; + + se = ss; + while ( *(++se) ) + { + if ( *se=='\t' ) break; + if ( *se!=',' ) continue; + reg->als[reg->nals] = ®->als_str.s[reg->als_str.l]; + kputsn(ss,se-ss,®->als_str); + if ( ®->als_str.s[reg->als_str.l] - reg->als[reg->nals] > max_len ) max_len = ®->als_str.s[reg->als_str.l] - reg->als[reg->nals]; + reg->als_str.l++; + reg->nals++; + ss = ++se; + } + reg->als[reg->nals] = ®->als_str.s[reg->als_str.l]; + kputsn(ss,se-ss,®->als_str); + if ( ®->als_str.s[reg->als_str.l] - reg->als[reg->nals] > max_len ) max_len = ®->als_str.s[reg->als_str.l] - reg->als[reg->nals]; + reg->nals++; + reg->als_type = max_len > 1 ? VCF_INDEL : VCF_SNP; // this is a simplified check, see vcf.c:bcf_set_variant_types + } + int type = bcf_get_variant_types(rec); + if ( reg->als_type & VCF_INDEL ) + return type & VCF_INDEL ? 1 : 0; + return !(type & VCF_INDEL) ? 1 : 0; +} + +int bcf_sr_regions_overlap(bcf_sr_regions_t *reg, const char *seq, int start, int end) +{ + int iseq; + if ( khash_str2int_get(reg->seq_hash, seq, &iseq)<0 ) return -1; // no such sequence + + if ( reg->prev_seq==-1 || iseq!=reg->prev_seq || reg->prev_start > start ) // new chromosome or after a seek + { + // flush regions left on previous chromosome + if ( reg->missed_reg_handler && reg->prev_seq!=-1 && reg->iseq!=-1 ) + bcf_sr_regions_flush(reg); + + bcf_sr_regions_seek(reg, seq); + reg->start = reg->end = -1; + } + if ( reg->prev_seq==iseq && reg->iseq!=iseq ) return -2; // no more regions on this chromosome + reg->prev_seq = reg->iseq; + reg->prev_start = start; + + while ( iseq==reg->iseq && reg->end < start ) + { + if ( bcf_sr_regions_next(reg) < 0 ) return -2; // no more regions left + if ( reg->iseq != iseq ) return -1; // does not overlap any regions + if ( reg->missed_reg_handler && reg->end < start ) reg->missed_reg_handler(reg, reg->missed_reg_data); + } + if ( reg->start <= end ) return 0; // region overlap + return -1; // no overlap +} + +void bcf_sr_regions_flush(bcf_sr_regions_t *reg) +{ + if ( !reg->missed_reg_handler || reg->prev_seq==-1 ) return; + while ( !bcf_sr_regions_next(reg) ) reg->missed_reg_handler(reg, reg->missed_reg_data); + return; +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/tabix.1 Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,180 @@ +.TH tabix 1 "3 February 2015" "htslib-1.2.1" "Bioinformatics tools" +.SH NAME +.PP +bgzip \- Block compression/decompression utility +.PP +tabix \- Generic indexer for TAB-delimited genome position files +.\" +.\" Copyright (C) 2009-2011 Broad Institute. +.\" +.\" Author: Heng Li <lh3@sanger.ac.uk> +.\" +.\" Permission is hereby granted, free of charge, to any person obtaining a +.\" copy of this software and associated documentation files (the "Software"), +.\" to deal in the Software without restriction, including without limitation +.\" the rights to use, copy, modify, merge, publish, distribute, sublicense, +.\" and/or sell copies of the Software, and to permit persons to whom the +.\" Software is furnished to do so, subject to the following conditions: +.\" +.\" The above copyright notice and this permission notice shall be included in +.\" all copies or substantial portions of the Software. +.\" +.\" THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +.\" IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +.\" FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +.\" THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +.\" LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +.\" FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +.\" DEALINGS IN THE SOFTWARE. +.\" +.SH SYNOPSIS +.PP +.B bgzip +.RB [ -cdhB ] +.RB [ -b +.IR virtualOffset ] +.RB [ -s +.IR size ] +.RI [ file ] +.PP +.B tabix +.RB [ -0lf ] +.RB [ -p +gff|bed|sam|vcf] +.RB [ -s +.IR seqCol ] +.RB [ -b +.IR begCol ] +.RB [ -e +.IR endCol ] +.RB [ -S +.IR lineSkip ] +.RB [ -c +.IR metaChar ] +.I in.tab.bgz +.RI [ "region1 " [ "region2 " [ ... "]]]" + +.SH DESCRIPTION +.PP +Tabix indexes a TAB-delimited genome position file +.I in.tab.bgz +and creates an index file ( +.I in.tab.bgz.tbi +or +.I in.tab.bgz.csi +) when +.I region +is absent from the command-line. The input data file must be position +sorted and compressed by +.B bgzip +which has a +.BR gzip (1) +like interface. After indexing, tabix is able to quickly retrieve data +lines overlapping +.I regions +specified in the format "chr:beginPos-endPos". Fast data retrieval also +works over network if URI is given as a file name and in this case the +index file will be downloaded if it is not present locally. + +.SH INDEXING OPTIONS +.TP 10 +.B -0, --zero-based +Specify that the position in the data file is 0-based (e.g. UCSC files) +rather than 1-based. +.TP +.BI "-b, --begin " INT +Column of start chromosomal position. [4] +.TP +.BI "-c, --comment " CHAR +Skip lines started with character CHAR. [#] +.TP +.BI "-C, --csi" +Skip lines started with character CHAR. [#] +.TP +.BI "-e, --end " INT +Column of end chromosomal position. The end column can be the same as the +start column. [5] +.TP +.B "-f, --force " +Force to overwrite the index file if it is present. +.TP +.BI "-m, --min-shift" INT +set minimal interval size for CSI indices to 2^INT [14] +.TP +.BI "-p, --preset " STR +Input format for indexing. Valid values are: gff, bed, sam, vcf. +This option should not be applied together with any of +.BR -s ", " -b ", " -e ", " -c " and " -0 ; +it is not used for data retrieval because this setting is stored in +the index file. [gff] +.TP +.BI "-s, --sequence " INT +Column of sequence name. Option +.BR -s ", " -b ", " -e ", " -S ", " -c " and " -0 +are all stored in the index file and thus not used in data retrieval. [1] +.TP +.BI "-S, --skip-lines " INT +Skip first INT lines in the data file. [0] + +.SH QUERYING AND OTHER OPTIONS +.TP +.B "-h, --print-header " +Print also the header/meta lines. +.TP +.B "-H, --only-header " +Print only the header/meta lines. +.TP +.B "-i, --file-info " +Print file format info. +.TP +.B "-l, --list-chroms " +List the sequence names stored in the index file. +.TP +.B "-r, --reheader " FILE +Replace the header with the content of FILE +.TP +.B "-R, --regions " FILE +Restrict to regions listed in the FILE. The FILE can be BED file (requires .bed, .bed.gz, .bed.bgz +file name extension) or a TAB-delimited file with CHROM, POS, and, optionally, +POS_TO columns, where positions are 1-based and inclusive. When this option is in use, the input +file may not be sorted. +regions. +.TP +.B "-T, --targets" FILE +Similar to +.B -R +but the entire input will be read sequentially and regions not listed in FILE will be skipped. +.PP +.SH EXAMPLE +(grep ^"#" in.gff; grep -v ^"#" in.gff | sort -k1,1 -k4,4n) | bgzip > sorted.gff.gz; + +tabix -p gff sorted.gff.gz; + +tabix sorted.gff.gz chr1:10,000,000-20,000,000; + +.SH NOTES +It is straightforward to achieve overlap queries using the standard +B-tree index (with or without binning) implemented in all SQL databases, +or the R-tree index in PostgreSQL and Oracle. But there are still many +reasons to use tabix. Firstly, tabix directly works with a lot of widely +used TAB-delimited formats such as GFF/GTF and BED. We do not need to +design database schema or specialized binary formats. Data do not need +to be duplicated in different formats, either. Secondly, tabix works on +compressed data files while most SQL databases do not. The GenCode +annotation GTF can be compressed down to 4%. Thirdly, tabix is +fast. The same indexing algorithm is known to work efficiently for an +alignment with a few billion short reads. SQL databases probably cannot +easily handle data at this scale. Last but not the least, tabix supports +remote data retrieval. One can put the data file and the index at an FTP +or HTTP server, and other users or even web services will be able to get +a slice without downloading the entire file. + +.SH AUTHOR +.PP +Tabix was written by Heng Li. The BGZF library was originally +implemented by Bob Handsaker and modified by Heng Li for remote file +access and in-memory caching. + +.SH SEE ALSO +.PP +.BR samtools (1)
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/tabix.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,519 @@ +/* tabix.c -- Generic indexer for TAB-delimited genome position files. + + Copyright (C) 2009-2011 Broad Institute. + Copyright (C) 2010-2012, 2014 Genome Research Ltd. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> +#include <stdlib.h> +#include <unistd.h> +#include <string.h> +#include <getopt.h> +#include <sys/types.h> +#include <sys/stat.h> +#include <errno.h> +#include "htslib/tbx.h" +#include "htslib/sam.h" +#include "htslib/vcf.h" +#include "htslib/kseq.h" +#include "htslib/bgzf.h" +#include "htslib/hts.h" +#include "htslib/regidx.h" + +typedef struct +{ + char *regions_fname, *targets_fname; + int print_header, header_only; +} +args_t; + +static void error(const char *format, ...) +{ + va_list ap; + va_start(ap, format); + vfprintf(stderr, format, ap); + va_end(ap); + exit(EXIT_FAILURE); +} + +#define IS_GFF (1<<0) +#define IS_BED (1<<1) +#define IS_SAM (1<<2) +#define IS_VCF (1<<3) +#define IS_BCF (1<<4) +#define IS_BAM (1<<5) +#define IS_CRAM (1<<6) +#define IS_TXT (IS_GFF|IS_BED|IS_SAM|IS_VCF) + +int file_type(const char *fname) +{ + int l = strlen(fname); + int strcasecmp(const char *s1, const char *s2); + if (l>=7 && strcasecmp(fname+l-7, ".gff.gz") == 0) return IS_GFF; + else if (l>=7 && strcasecmp(fname+l-7, ".bed.gz") == 0) return IS_BED; + else if (l>=7 && strcasecmp(fname+l-7, ".sam.gz") == 0) return IS_SAM; + else if (l>=7 && strcasecmp(fname+l-7, ".vcf.gz") == 0) return IS_VCF; + else if (l>=4 && strcasecmp(fname+l-4, ".bcf") == 0) return IS_BCF; + else if (l>=4 && strcasecmp(fname+l-4, ".bam") == 0) return IS_BAM; + else if (l>=4 && strcasecmp(fname+l-5, ".cram") == 0) return IS_CRAM; + + htsFile *fp = hts_open(fname,"r"); + enum htsExactFormat format = fp->format.format; + hts_close(fp); + if ( format == bcf ) return IS_BCF; + if ( format == bam ) return IS_BAM; + if ( format == cram ) return IS_CRAM; + if ( format == vcf ) return IS_VCF; + + return 0; +} + +static char **parse_regions(char *regions_fname, char **argv, int argc, int *nregs) +{ + kstring_t str = {0,0,0}; + int iseq = 0, ireg = 0; + char **regs = NULL; + *nregs = argc; + + if ( regions_fname ) + { + // improve me: this is a too heavy machinery for parsing regions... + + regidx_t *idx = regidx_init(regions_fname, NULL, NULL, 0, NULL); + if ( !idx ) error("Could not read %s\n", regions_fname); + + (*nregs) += regidx_nregs(idx); + regs = (char**) malloc(sizeof(char*)*(*nregs)); + + int nseq; + char **seqs = regidx_seq_names(idx, &nseq); + for (iseq=0; iseq<nseq; iseq++) + { + regitr_t itr; + regidx_overlap(idx, seqs[iseq], 0, UINT32_MAX, &itr); + while ( itr.i < itr.n ) + { + str.l = 0; + ksprintf(&str, "%s:%d-%d", seqs[iseq], REGITR_START(itr)+1, REGITR_END(itr)+1); + regs[ireg++] = strdup(str.s); + itr.i++; + } + } + regidx_destroy(idx); + } + free(str.s); + + if ( !ireg ) + { + if ( argc ) + regs = (char**) malloc(sizeof(char*)*argc); + else + { + regs = (char**) malloc(sizeof(char*)); + regs[0] = strdup("."); + *nregs = 1; + } + } + + for (iseq=0; iseq<argc; iseq++) regs[ireg++] = strdup(argv[iseq]); + return regs; +} +static int query_regions(args_t *args, char *fname, char **regs, int nregs) +{ + int i; + htsFile *fp = hts_open(fname,"r"); + if ( !fp ) error("Could not read %s\n", fname); + enum htsExactFormat format = hts_get_format(fp)->format; + + regidx_t *reg_idx = NULL; + if ( args->targets_fname ) + { + reg_idx = regidx_init(args->targets_fname, NULL, NULL, 0, NULL); + if ( !reg_idx ) error("Could not read %s\n", args->targets_fname); + } + + if ( format == bcf ) + { + htsFile *out = hts_open("-","w"); + if ( !out ) error("Could not open stdout\n", fname); + hts_idx_t *idx = bcf_index_load(fname); + if ( !idx ) error("Could not load .csi index of %s\n", fname); + bcf_hdr_t *hdr = bcf_hdr_read(fp); + if ( !hdr ) error("Could not read the header: %s\n", fname); + if ( args->print_header ) + bcf_hdr_write(out,hdr); + if ( !args->header_only ) + { + bcf1_t *rec = bcf_init(); + for (i=0; i<nregs; i++) + { + hts_itr_t *itr = bcf_itr_querys(idx,hdr,regs[i]); + while ( bcf_itr_next(fp, itr, rec) >=0 ) + { + if ( reg_idx && !regidx_overlap(reg_idx, bcf_seqname(hdr,rec),rec->pos,rec->pos+rec->rlen-1, NULL) ) continue; + bcf_write(out,hdr,rec); + } + tbx_itr_destroy(itr); + } + bcf_destroy(rec); + } + if ( hts_close(out) ) error("hts_close returned non-zero status for stdout\n"); + bcf_hdr_destroy(hdr); + hts_idx_destroy(idx); + } + else if ( format==vcf || format==sam || format==unknown_format ) + { + tbx_t *tbx = tbx_index_load(fname); + if ( !tbx ) error("Could not load .tbi/.csi index of %s\n", fname); + kstring_t str = {0,0,0}; + if ( args->print_header ) + { + while ( hts_getline(fp, KS_SEP_LINE, &str) >= 0 ) + { + if ( !str.l || str.s[0]!=tbx->conf.meta_char ) break; + puts(str.s); + } + } + if ( !args->header_only ) + { + int nseq; + const char **seq = NULL; + if ( reg_idx ) seq = tbx_seqnames(tbx, &nseq); + for (i=0; i<nregs; i++) + { + hts_itr_t *itr = tbx_itr_querys(tbx, regs[i]); + if ( !itr ) continue; + while (tbx_itr_next(fp, tbx, itr, &str) >= 0) + { + if ( reg_idx && !regidx_overlap(reg_idx,seq[itr->curr_tid],itr->curr_beg,itr->curr_end, NULL) ) continue; + puts(str.s); + } + tbx_itr_destroy(itr); + } + free(seq); + } + free(str.s); + tbx_destroy(tbx); + } + else if ( format==bam ) + error("Please use \"samtools view\" for querying BAM files.\n"); + + if ( reg_idx ) regidx_destroy(reg_idx); + if ( hts_close(fp) ) error("hts_close returned non-zero status: %s\n", fname); + + for (i=0; i<nregs; i++) free(regs[i]); + free(regs); + return 0; +} +static int query_chroms(char *fname) +{ + const char **seq; + int i, nseq, ftype = file_type(fname); + if ( ftype & IS_TXT || !ftype ) + { + tbx_t *tbx = tbx_index_load(fname); + if ( !tbx ) error("Could not load .tbi index of %s\n", fname); + seq = tbx_seqnames(tbx, &nseq); + for (i=0; i<nseq; i++) + printf("%s\n", seq[i]); + free(seq); + tbx_destroy(tbx); + } + else if ( ftype==IS_BCF ) + { + htsFile *fp = hts_open(fname,"r"); + if ( !fp ) error("Could not read %s\n", fname); + bcf_hdr_t *hdr = bcf_hdr_read(fp); + if ( !hdr ) error("Could not read the header: %s\n", fname); + hts_close(fp); + hts_idx_t *idx = bcf_index_load(fname); + if ( !idx ) error("Could not load .csi index of %s\n", fname); + seq = bcf_index_seqnames(idx, hdr, &nseq); + for (i=0; i<nseq; i++) + printf("%s\n", seq[i]); + free(seq); + bcf_hdr_destroy(hdr); + hts_idx_destroy(idx); + } + else if ( ftype==IS_BAM ) // todo: BAM + error("BAM: todo\n"); + return 0; +} + +int reheader_file(const char *fname, const char *header, int ftype, tbx_conf_t *conf) +{ + if ( ftype & IS_TXT || !ftype ) + { + BGZF *fp = bgzf_open(fname,"r"); + if ( !fp || bgzf_read_block(fp) != 0 || !fp->block_length ) return -1; + + char *buffer = fp->uncompressed_block; + int skip_until = 0; + + // Skip the header: find out the position of the data block + if ( buffer[0]==conf->meta_char ) + { + skip_until = 1; + while (1) + { + if ( buffer[skip_until]=='\n' ) + { + skip_until++; + if ( skip_until>=fp->block_length ) + { + if ( bgzf_read_block(fp) != 0 || !fp->block_length ) error("FIXME: No body in the file: %s\n", fname); + skip_until = 0; + } + // The header has finished + if ( buffer[skip_until]!=conf->meta_char ) break; + } + skip_until++; + if ( skip_until>=fp->block_length ) + { + if (bgzf_read_block(fp) != 0 || !fp->block_length) error("FIXME: No body in the file: %s\n", fname); + skip_until = 0; + } + } + } + + // Output the new header + FILE *hdr = fopen(header,"r"); + if ( !hdr ) error("%s: %s", header,strerror(errno)); + int page_size = getpagesize(); + char *buf = valloc(page_size); + BGZF *bgzf_out = bgzf_dopen(fileno(stdout), "w"); + ssize_t nread; + while ( (nread=fread(buf,1,page_size-1,hdr))>0 ) + { + if ( nread<page_size-1 && buf[nread-1]!='\n' ) buf[nread++] = '\n'; + if (bgzf_write(bgzf_out, buf, nread) < 0) error("Error: %d\n",bgzf_out->errcode); + } + if ( fclose(hdr) ) error("close failed: %s\n", header); + + // Output all remainig data read with the header block + if ( fp->block_length - skip_until > 0 ) + { + if (bgzf_write(bgzf_out, buffer+skip_until, fp->block_length-skip_until) < 0) error("Error: %d\n",fp->errcode); + } + if (bgzf_flush(bgzf_out) < 0) error("Error: %d\n",bgzf_out->errcode); + + while (1) + { + nread = bgzf_raw_read(fp, buf, page_size); + if ( nread<=0 ) break; + + int count = bgzf_raw_write(bgzf_out, buf, nread); + if (count != nread) error("Write failed, wrote %d instead of %d bytes.\n", count,(int)nread); + } + if (bgzf_close(bgzf_out) < 0) error("Error: %d\n",bgzf_out->errcode); + if (bgzf_close(fp) < 0) error("Error: %d\n",fp->errcode); + } + else + error("todo: reheader BCF, BAM\n"); // BCF is difficult, records contain pointers to the header. + return 0; +} + +static int usage(void) +{ + fprintf(stderr, "\n"); + fprintf(stderr, "Version: %s\n", hts_version()); + fprintf(stderr, "Usage: tabix [OPTIONS] [FILE] [REGION [...]]\n"); + fprintf(stderr, "\n"); + fprintf(stderr, "Indexing Options:\n"); + fprintf(stderr, " -0, --zero-based coordinates are zero-based\n"); + fprintf(stderr, " -b, --begin INT column number for region start [4]\n"); + fprintf(stderr, " -c, --comment CHAR skip comment lines starting with CHAR [null]\n"); + fprintf(stderr, " -C, --csi generate CSI index for VCF (default is TBI)\n"); + fprintf(stderr, " -e, --end INT column number for region end (if no end, set INT to -b) [5]\n"); + fprintf(stderr, " -f, --force overwrite existing index without asking\n"); + fprintf(stderr, " -m, --min-shift INT set minimal interval size for CSI indices to 2^INT [14]\n"); + fprintf(stderr, " -p, --preset STR gff, bed, sam, vcf\n"); + fprintf(stderr, " -s, --sequence INT column number for sequence names (suppressed by -p) [1]\n"); + fprintf(stderr, " -S, --skip-lines INT skip first INT lines [0]\n"); + fprintf(stderr, "\n"); + fprintf(stderr, "Querying and other options:\n"); + fprintf(stderr, " -h, --print-header print also the header lines\n"); + fprintf(stderr, " -H, --only-header print only the header lines\n"); + fprintf(stderr, " -l, --list-chroms list chromosome names\n"); + fprintf(stderr, " -r, --reheader FILE replace the header with the content of FILE\n"); + fprintf(stderr, " -R, --regions FILE restrict to regions listed in the file\n"); + fprintf(stderr, " -T, --targets FILE similar to -R but streams rather than index-jumps\n"); + fprintf(stderr, "\n"); + return 1; +} + +int main(int argc, char *argv[]) +{ + int c, min_shift = 0, is_force = 0, list_chroms = 0, do_csi = 0; + tbx_conf_t conf = tbx_conf_gff, *conf_ptr = NULL; + char *reheader = NULL; + args_t args; + memset(&args,0,sizeof(args_t)); + + static struct option loptions[] = + { + {"help",0,0,'h'}, + {"regions",1,0,'R'}, + {"targets",1,0,'T'}, + {"csi",0,0,'C'}, + {"zero-based",0,0,'0'}, + {"print-header",0,0,'h'}, + {"only-header",0,0,'H'}, + {"begin",1,0,'b'}, + {"comment",1,0,'c'}, + {"end",1,0,'e'}, + {"force",0,0,'f'}, + {"preset",1,0,'p'}, + {"sequence",1,0,'s'}, + {"skip-lines",1,0,'S'}, + {"list-chroms",0,0,'l'}, + {"reheader",1,0,'r'}, + {0,0,0,0} + }; + + while ((c = getopt_long(argc, argv, "hH?0b:c:e:fm:p:s:S:lr:CR:T:", loptions,NULL)) >= 0) + { + switch (c) + { + case 'R': args.regions_fname = optarg; break; + case 'T': args.targets_fname = optarg; break; + case 'C': do_csi = 1; break; + case 'r': reheader = optarg; break; + case 'h': args.print_header = 1; break; + case 'H': args.header_only = 1; break; + case 'l': list_chroms = 1; break; + case '0': conf.preset |= TBX_UCSC; break; + case 'b': conf.bc = atoi(optarg); break; + case 'e': conf.ec = atoi(optarg); break; + case 'c': conf.meta_char = *optarg; break; + case 'f': is_force = 1; break; + case 'm': min_shift = atoi(optarg); break; + case 'p': + if (strcmp(optarg, "gff") == 0) conf_ptr = &tbx_conf_gff; + else if (strcmp(optarg, "bed") == 0) conf_ptr = &tbx_conf_bed; + else if (strcmp(optarg, "sam") == 0) conf_ptr = &tbx_conf_sam; + else if (strcmp(optarg, "vcf") == 0) conf_ptr = &tbx_conf_vcf; + else if (strcmp(optarg, "bcf") == 0) ; // bcf is autodetected, preset is not needed + else if (strcmp(optarg, "bam") == 0) ; // same as bcf + else error("The preset string not recognised: '%s'\n", optarg); + break; + case 's': conf.sc = atoi(optarg); break; + case 'S': conf.line_skip = atoi(optarg); break; + default: return usage(); + } + } + + if ( optind==argc ) return usage(); + + if ( list_chroms ) + return query_chroms(argv[optind]); + + if ( argc > optind+1 || args.header_only || args.regions_fname || args.targets_fname ) + { + int nregs = 0; + char **regs = NULL; + if ( !args.header_only ) + regs = parse_regions(args.regions_fname, argv+optind+1, argc-optind-1, &nregs); + return query_regions(&args, argv[optind], regs, nregs); + } + + char *fname = argv[optind]; + int ftype = file_type(fname); + if ( !conf_ptr ) // no preset given + { + if ( ftype==IS_GFF ) conf_ptr = &tbx_conf_gff; + else if ( ftype==IS_BED ) conf_ptr = &tbx_conf_bed; + else if ( ftype==IS_SAM ) conf_ptr = &tbx_conf_sam; + else if ( ftype==IS_VCF ) + { + conf_ptr = &tbx_conf_vcf; + if ( !min_shift && do_csi ) min_shift = 14; + } + else if ( ftype==IS_BCF ) + { + if ( !min_shift ) min_shift = 14; + } + else if ( ftype==IS_BAM ) + { + if ( !min_shift ) min_shift = 14; + } + } + if ( do_csi ) + { + if ( !min_shift ) min_shift = 14; + min_shift *= do_csi; // positive for CSIv2, negative for CSIv1 + } + if ( min_shift!=0 && !do_csi ) do_csi = 1; + + if ( reheader ) + return reheader_file(fname, reheader, ftype, conf_ptr); + + if ( conf_ptr ) + conf = *conf_ptr; + + char *suffix = ".tbi"; + if ( do_csi ) suffix = ".csi"; + else if ( ftype==IS_BAM ) suffix = ".bai"; + else if ( ftype==IS_CRAM ) suffix = ".crai"; + + char *idx_fname = calloc(strlen(fname) + 5, 1); + strcat(strcpy(idx_fname, fname), suffix); + + struct stat stat_tbi, stat_file; + if ( !is_force && stat(idx_fname, &stat_tbi)==0 ) + { + // Before complaining about existing index, check if the VCF file isn't + // newer. This is a common source of errors, people tend not to notice + // that tabix failed + stat(fname, &stat_file); + if ( stat_file.st_mtime <= stat_tbi.st_mtime ) + error("[tabix] the index file exists. Please use '-f' to overwrite.\n"); + } + free(idx_fname); + + if ( ftype==IS_CRAM ) + { + if ( bam_index_build(fname, min_shift)!=0 ) error("bam_index_build failed: %s\n", fname); + return 0; + } + else if ( do_csi ) + { + if ( ftype==IS_BCF ) + { + if ( bcf_index_build(fname, min_shift)!=0 ) error("bcf_index_build failed: %s\n", fname); + return 0; + } + if ( ftype==IS_BAM ) + { + if ( bam_index_build(fname, min_shift)!=0 ) error("bam_index_build failed: %s\n", fname); + return 0; + } + if ( tbx_index_build(fname, min_shift, &conf)!=0 ) error("tbx_index_build failed: %s\n", fname); + return 0; + } + else // TBI index + { + if ( tbx_index_build(fname, min_shift, &conf) ) error("tbx_index_build failed: %s\n", fname); + return 0; + } + return 0; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/tbx.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,320 @@ +/* tbx.c -- tabix API functions. + + Copyright (C) 2009, 2010, 2012-2014 Genome Research Ltd. + Copyright (C) 2010-2012 Broad Institute. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdlib.h> +#include <string.h> +#include <ctype.h> +#include <stdio.h> +#include <assert.h> +#include "htslib/tbx.h" +#include "htslib/bgzf.h" + +#include "htslib/khash.h" +KHASH_DECLARE(s2i, kh_cstr_t, int64_t) + +tbx_conf_t tbx_conf_gff = { 0, 1, 4, 5, '#', 0 }; +tbx_conf_t tbx_conf_bed = { TBX_UCSC, 1, 2, 3, '#', 0 }; +tbx_conf_t tbx_conf_psltbl = { TBX_UCSC, 15, 17, 18, '#', 0 }; +tbx_conf_t tbx_conf_sam = { TBX_SAM, 3, 4, 0, '@', 0 }; +tbx_conf_t tbx_conf_vcf = { TBX_VCF, 1, 2, 0, '#', 0 }; + +typedef struct { + int64_t beg, end; + char *ss, *se; + int tid; +} tbx_intv_t; + +static inline int get_tid(tbx_t *tbx, const char *ss, int is_add) +{ + khint_t k; + khash_t(s2i) *d; + if (tbx->dict == 0) tbx->dict = kh_init(s2i); + d = (khash_t(s2i)*)tbx->dict; + if (is_add) { + int absent; + k = kh_put(s2i, d, ss, &absent); + if (absent) { + kh_key(d, k) = strdup(ss); + kh_val(d, k) = kh_size(d) - 1; + } + } else k = kh_get(s2i, d, ss); + return k == kh_end(d)? -1 : kh_val(d, k); +} + +int tbx_name2id(tbx_t *tbx, const char *ss) +{ + return get_tid(tbx, ss, 0); +} + +int tbx_parse1(const tbx_conf_t *conf, int len, char *line, tbx_intv_t *intv) +{ + int i, b = 0, id = 1, ncols = 0; + char *s; + intv->ss = intv->se = 0; intv->beg = intv->end = -1; + for (i = 0; i <= len; ++i) { + if (line[i] == '\t' || line[i] == 0) { + ++ncols; + if (id == conf->sc) { + intv->ss = line + b; intv->se = line + i; + } else if (id == conf->bc) { + // here ->beg is 0-based. + intv->beg = intv->end = strtol(line + b, &s, 0); + if ( s==line+b ) return -1; // expected int + if (!(conf->preset&TBX_UCSC)) --intv->beg; + else ++intv->end; + if (intv->beg < 0) intv->beg = 0; + if (intv->end < 1) intv->end = 1; + } else { + if ((conf->preset&0xffff) == TBX_GENERIC) { + if (id == conf->ec) + { + intv->end = strtol(line + b, &s, 0); + if ( s==line+b ) return -1; // expected int + } + } else if ((conf->preset&0xffff) == TBX_SAM) { + if (id == 6) { // CIGAR + int l = 0, op; + char *t; + for (s = line + b; s < line + i;) { + long x = strtol(s, &t, 10); + op = toupper(*t); + if (op == 'M' || op == 'D' || op == 'N') l += x; + s = t + 1; + } + if (l == 0) l = 1; + intv->end = intv->beg + l; + } + } else if ((conf->preset&0xffff) == TBX_VCF) { + if (id == 4) { + if (b < i) intv->end = intv->beg + (i - b); + } else if (id == 8) { // look for "END=" + int c = line[i]; + line[i] = 0; + s = strstr(line + b, "END="); + if (s == line + b) s += 4; + else if (s) { + s = strstr(line + b, ";END="); + if (s) s += 5; + } + if (s) intv->end = strtol(s, &s, 0); + line[i] = c; + } + } + } + b = i + 1; + ++id; + } + } + if (intv->ss == 0 || intv->se == 0 || intv->beg < 0 || intv->end < 0) return -1; + return 0; +} + +static inline int get_intv(tbx_t *tbx, kstring_t *str, tbx_intv_t *intv, int is_add) +{ + if (tbx_parse1(&tbx->conf, str->l, str->s, intv) == 0) { + int c = *intv->se; + *intv->se = '\0'; intv->tid = get_tid(tbx, intv->ss, is_add); *intv->se = c; + return (intv->tid >= 0 && intv->beg >= 0 && intv->end >= 0)? 0 : -1; + } else { + char *type = NULL; + switch (tbx->conf.preset&0xffff) + { + case TBX_SAM: type = "TBX_SAM"; break; + case TBX_VCF: type = "TBX_VCF"; break; + case TBX_UCSC: type = "TBX_UCSC"; break; + default: type = "TBX_GENERIC"; break; + } + fprintf(stderr, "[E::%s] failed to parse %s, was wrong -p [type] used?\nThe offending line was: \"%s\"\n", __func__, type, str->s); + return -1; + } +} + +int tbx_readrec(BGZF *fp, void *tbxv, void *sv, int *tid, int *beg, int *end) +{ + tbx_t *tbx = (tbx_t *) tbxv; + kstring_t *s = (kstring_t *) sv; + int ret; + if ((ret = bgzf_getline(fp, '\n', s)) >= 0) { + tbx_intv_t intv; + get_intv(tbx, s, &intv, 0); + *tid = intv.tid; *beg = intv.beg; *end = intv.end; + } + return ret; +} + +void tbx_set_meta(tbx_t *tbx) +{ + int i, l = 0, l_nm; + uint32_t x[7]; + char **name; + uint8_t *meta; + khint_t k; + khash_t(s2i) *d = (khash_t(s2i)*)tbx->dict; + + memcpy(x, &tbx->conf, 24); + name = (char**)malloc(sizeof(char*) * kh_size(d)); + for (k = kh_begin(d), l = 0; k != kh_end(d); ++k) { + if (!kh_exist(d, k)) continue; + name[kh_val(d, k)] = (char*)kh_key(d, k); + l += strlen(kh_key(d, k)) + 1; // +1 to include '\0' + } + l_nm = x[6] = l; + meta = (uint8_t*)malloc(l_nm + 28); + if (ed_is_big()) + for (i = 0; i < 7; ++i) + x[i] = ed_swap_4(x[i]); + memcpy(meta, x, 28); + for (l = 28, i = 0; i < (int)kh_size(d); ++i) { + int x = strlen(name[i]) + 1; + memcpy(meta + l, name[i], x); + l += x; + } + free(name); + hts_idx_set_meta(tbx->idx, l, meta, 0); +} + +tbx_t *tbx_index(BGZF *fp, int min_shift, const tbx_conf_t *conf) +{ + tbx_t *tbx; + kstring_t str; + int ret, first = 0, n_lvls, fmt; + int64_t lineno = 0; + uint64_t last_off = 0; + tbx_intv_t intv; + + str.s = 0; str.l = str.m = 0; + tbx = (tbx_t*)calloc(1, sizeof(tbx_t)); + tbx->conf = *conf; + if (min_shift > 0) n_lvls = (TBX_MAX_SHIFT - min_shift + 2) / 3, fmt = HTS_FMT_CSI; + else min_shift = 14, n_lvls = 5, fmt = HTS_FMT_TBI; + while ((ret = bgzf_getline(fp, '\n', &str)) >= 0) { + ++lineno; + if (lineno <= tbx->conf.line_skip || str.s[0] == tbx->conf.meta_char) { + last_off = bgzf_tell(fp); + continue; + } + if (first == 0) { + tbx->idx = hts_idx_init(0, fmt, last_off, min_shift, n_lvls); + first = 1; + } + get_intv(tbx, &str, &intv, 1); + ret = hts_idx_push(tbx->idx, intv.tid, intv.beg, intv.end, bgzf_tell(fp), 1); + if (ret < 0) + { + free(str.s); + tbx_destroy(tbx); + return NULL; + } + } + if ( !tbx->idx ) tbx->idx = hts_idx_init(0, fmt, last_off, min_shift, n_lvls); // empty file + if ( !tbx->dict ) tbx->dict = kh_init(s2i); + hts_idx_finish(tbx->idx, bgzf_tell(fp)); + tbx_set_meta(tbx); + free(str.s); + return tbx; +} + +void tbx_destroy(tbx_t *tbx) +{ + khash_t(s2i) *d = (khash_t(s2i)*)tbx->dict; + if (d != NULL) + { + khint_t k; + for (k = kh_begin(d); k != kh_end(d); ++k) + if (kh_exist(d, k)) free((char*)kh_key(d, k)); + } + hts_idx_destroy(tbx->idx); + kh_destroy(s2i, d); + free(tbx); +} + +int tbx_index_build(const char *fn, int min_shift, const tbx_conf_t *conf) +{ + tbx_t *tbx; + BGZF *fp; + if ( bgzf_is_bgzf(fn)!=1 ) { fprintf(stderr,"Not a BGZF file: %s\n", fn); return -1; } + if ((fp = bgzf_open(fn, "r")) == 0) return -1; + if ( !fp->is_compressed ) { bgzf_close(fp); return -1; } + tbx = tbx_index(fp, min_shift, conf); + bgzf_close(fp); + if ( !tbx ) return -1; + hts_idx_save(tbx->idx, fn, min_shift > 0? HTS_FMT_CSI : HTS_FMT_TBI); + tbx_destroy(tbx); + return 0; +} + +tbx_t *tbx_index_load(const char *fn) +{ + tbx_t *tbx; + uint8_t *meta; + char *nm, *p; + uint32_t x[7]; + int l_meta, l_nm; + tbx = (tbx_t*)calloc(1, sizeof(tbx_t)); + tbx->idx = hts_idx_load(fn, HTS_FMT_TBI); + if ( !tbx->idx ) + { + free(tbx); + return NULL; + } + meta = hts_idx_get_meta(tbx->idx, &l_meta); + if ( !meta ) + { + free(tbx); + return NULL; + } + memcpy(x, meta, 28); + memcpy(&tbx->conf, x, 24); + p = nm = (char*)meta + 28; + l_nm = x[6]; + for (; p - nm < l_nm; p += strlen(p) + 1) get_tid(tbx, p, 1); + return tbx; +} + +const char **tbx_seqnames(tbx_t *tbx, int *n) +{ + khash_t(s2i) *d = (khash_t(s2i)*)tbx->dict; + if (d == NULL) + { + *n = 0; + return NULL; + } + int tid, m = kh_size(d); + const char **names = (const char**) calloc(m,sizeof(const char*)); + khint_t k; + for (k=kh_begin(d); k<kh_end(d); k++) + { + if ( !kh_exist(d,k) ) continue; + tid = kh_val(d,k); + assert( tid<m ); + names[tid] = kh_key(d,k); + } + // sanity check: there should be no gaps + for (tid=0; tid<m; tid++) + assert(names[tid]); + *n = m; + return names; +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/auxf#values.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +@HD VN:1.4 SO:unsorted +@SQ SN:Sheila LN:20 +@RG ID:ID SM:foo +Fred 16 Sheila 1 86 10M * 0 0 GCTAGCTCAG ********** RG:Z:ID A!:A:! Ac:A:c AC:A:C I0:i:0 I1:i:1 I2:i:127 I3:i:128 I4:i:255 I5:i:256 I6:i:32767 I7:i:32768 I8:i:65535 I9:i:65536 IA:i:2147483647 i1:i:-1 i2:i:-127 i3:i:-128 i4:i:-255 i5:i:-256 i6:i:-32767 i7:i:-32768 i8:i:-65535 i9:i:-65536 iA:i:-2147483647 iB:i:-2147483648 F0:f:-1 F1:f:0 F2:f:1 F3:f:9.9e-19 F4:f:-9.9e-19 F5:f:9.9e+19 F6:f:-9.9e+19 H0:H:AA H1:H:dead00beef Z0:Z:space space +Jim 16 Sheila 11 11 10M * 0 0 AAAAAAAAAA * BC:B:C,0,127,128,255 Bc:B:c,-128,-127,0,127 BS:B:S,0,32767,32768,65535 Bs:B:s,-32768,-32767,0,32767 BI:B:I,0,2147483647,2147483648,4294967295 Bi:B:i,-2147483648,-2147483647,0,2147483647
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/auxf.fa Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,2 @@ +>Sheila +GCTAGCTCAGAAAAAAAAAA
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/auxf.fa.fai Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1 @@ +Sheila 20 8 20 21
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/c1#bounds.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,4 @@ +@SQ SN:c1 LN:10 +s0 0 c1 1 0 10M * 0 0 AACCGCGGTT ********** +s1 0 c1 2 0 10M * 0 0 ACCGCGGTTC ********** +s2 0 c1 3 0 10M * 0 0 CCGCGGTTCG **********
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/c1#clip.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,8 @@ +@SQ SN:c1 LN:10 +s0a 0 c1 1 0 10M * 0 0 AACCGCGGTT ********** +s0A 0 c1 1 0 3M4N3M * 0 0 AACGTT ****** +s0b 0 c1 2 0 1S8M1S * 0 0 AACCGCGGTT ********** +s0B 0 c1 2 0 1H8M1H * 0 0 ACCGCGGT ******** +s0c 0 c1 3 0 2S6M2S * 0 0 AACCGCGGTT ********** +s0c 0 c1 3 0 2S3M2I3M2S * 0 0 AACCGNNCGGTT ************ +s0C 0 c1 3 0 2H6M2H * 0 0 CCGCGG ******
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/c1#pad1.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,10 @@ +@SQ SN:c1 LN:10 +s0a 0 c1 1 0 10M * 0 0 AACCGCGGTT * +s0b 0 c1 1 0 10M * 0 0 AACCGCGGTT * +s0c 0 c1 1 0 10M * 0 0 AACCGCGGTT * +s1 0 c1 1 0 5M6I5M * 0 0 AACCGGTTAACCGGTT * +s2 0 c1 1 0 5M1P4I1P5M * 0 0 AACCGTTAACGGTT * +s3 0 c1 1 0 5M3I3P5M * 0 0 AACCGGTTCGGTT * +s4 0 c1 1 0 5M3P3I5M * 0 0 AACCGAACCGGTT * +s5 0 c1 1 0 4M1D2P2I2P1D4M * 0 0 AACCTAGGTT * +s6 0 c1 1 0 2M3D6I3D2M * 0 0 AAGTTAACTT *
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/c1#pad2.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,14 @@ +@SQ SN:c1 LN:50 +s0a 0 c1 1 0 10M * 0 0 AACCGCGGTT * +s0b 0 c1 1 0 10M * 0 0 AACCGCGGTT * +s0c 0 c1 1 0 10M * 0 0 AACCGCGGTT * +s0d 0 c1 1 0 10M * 0 0 AACCGCGGTT * +s1 0 c1 1 0 5M6I5M * 0 0 AACCGGTTAACCGGTT * +s2 0 c1 1 0 5M1P4I1P5M * 0 0 AACCGTTAACGGTT * +s3 0 c1 1 0 5M3I3P5M * 0 0 AACCGGTTCGGTT * +s4 0 c1 1 0 5M3P3I5M * 0 0 AACCGAACCGGTT * +s5 0 c1 1 0 4M1D2P2I2P1D4M * 0 0 AACCTAGGTT * +s6 0 c1 1 0 2M3D6I3D2M * 0 0 AAGTTAACTT * +s7 0 c1 1 0 4M2D4M * 0 0 AACCGGTT * +s8 0 c1 1 0 5D2P2I2P5D * 0 0 TA * +s9 0 c1 5 0 1M2P2I2P * 0 0 GTA *
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/c1#pad3.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,14 @@ +@SQ SN:c1 LN:16 +@RG ID:p.sam SM:unknown LB:p.sam +s0a 0 c1 6 0 5I6P5M * 0 0 AACCGCGGTT * RG:Z:p.sam +s0b 0 c1 6 0 5I6P5M * 0 0 AACCGCGGTT * RG:Z:p.sam +s0c 0 c1 6 0 5I6P5M * 0 0 AACCGCGGTT * RG:Z:p.sam +s0d 0 c1 6 0 5I6P5M * 0 0 AACCGCGGTT * RG:Z:p.sam +s1 0 c1 6 0 11I5M * 0 0 AACCGGTTAACCGGTT * RG:Z:p.sam +s2 0 c1 6 0 5I1P4I1P5M * 0 0 AACCGTTAACGGTT * RG:Z:p.sam +s3 0 c1 6 0 8I3P5M * 0 0 AACCGGTTCGGTT * RG:Z:p.sam +s4 0 c1 6 0 5I3P3I5M * 0 0 AACCGAACCGGTT * RG:Z:p.sam +s5 0 c1 6 0 4I3P2I2P1D4M * 0 0 AACCTAGGTT * RG:Z:p.sam +s6 0 c1 6 0 2I3P6I3D2M * 0 0 AAGTTAACTT * RG:Z:p.sam +s7 0 c1 6 0 4I7P1D4M * 0 0 AACCGGTT * RG:Z:p.sam +s8 0 c1 6 0 7P2I2P * 0 0 TA !! RG:Z:p.sam
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/c1.fa Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,2 @@ +>c1 +AACCGCGGTT
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/c1.fa.fai Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1 @@ +c1 10 4 10 11
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#1.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,2 @@ +@SQ SN:CHROMOSOME_I LN:15072423 +SRR065390.14978392 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 AS:i:-18 XS:i:-18 YT:Z:UU
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#2.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3 @@ +@SQ SN:CHROMOSOME_I LN:15072423 +SRR065390.14978392 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +SRR065390.921023 16 CHROMOSOME_I 3 12 100M * 0 0 CTAAGCCTAAATCTAAGCCTAACCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ###############################################???88:;98768700000<>:BBA?BBAB?BBBBBBBB>B>BB::;?:00000 XG:i:0 XM:i:3 XN:i:0 XO:i:0 AS:i:-6 XS:i:-13 YT:Z:UU
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#5.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,11 @@ +@SQ SN:CHROMOSOME_I LN:15072423 +@SQ SN:CHROMOSOME_II LN:15279345 +@SQ SN:CHROMOSOME_III LN:13783700 +@SQ SN:CHROMOSOME_IV LN:17493793 +@SQ SN:CHROMOSOME_V LN:20924149 +I 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +II.14978392 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +III 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +IV 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +V 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +VI 2048 CHROMOSOME_I 2 1 27M100000D73M * 0 0 ACTAAGCCTAAGCCTAAGCCTAAGCCAATTATCGATTTCTGAAAAAATTATCGAATTTTCTAGAAATTTTGCAAATTTTTTCATAAAATTATCGATTTTA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#5b.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,12 @@ +@SQ SN:CHROMOSOME_I LN:15072423 +@SQ SN:CHROMOSOME_II LN:15279345 +@SQ SN:CHROMOSOME_III LN:13783700 +@SQ SN:CHROMOSOME_IV LN:17493793 +@SQ SN:CHROMOSOME_V LN:20924149 +I 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +II.14978392 16 CHROMOSOME_II 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +III 16 CHROMOSOME_III 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +IV 16 CHROMOSOME_IV 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +V 16 CHROMOSOME_V 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 XS:i:-18 AS:i:-18 YT:Z:UU +VI 0 CHROMOSOME_V 10 1 7S20M1D23M10I30M10S * 0 0 AGCCTAAGCCTAAGCCTAAGCCTAAGCTAAGCCTAAGCCTAAGCCTAAGCTTTTTTTTTTCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA * +VI 256 CHROMOSOME_V 10 1 7S20M1D23M10I30M10S * 0 0 * *
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#large_seq.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3 @@ +@SQ SN:CHROMOSOME_I LN:15072423 +S1 0 CHROMOSOME_I 1 255 36M4I33M2D18M4I13M3I5M2I7M1I8M4I30M1D20M5D25M4D63M1D31M2I13M4I83M3I36M4D77M2D8M2D5M2D14M2I5M4D1M1D27M5I3M4D47M2D5M4D7M1I70M3D42M4I59M5I2M2I13M4D3M5D6M4I5M4I58M1I10M3I57M1I15M5D57M4I10M1I19M4D9M3I27M4D11M3I9M4I21M4I62M4I51M1I8M3D23M1I5M4I24M2D1M5I4M4D14M3D63M5I1M2I20M4D10M5D7M2D22M4I22M2I9M3I46M5I1M4D12M5D8M3D17M5D149M1D20M1D61M1I14M2I38M4D9M4I62M1I8M1I55M3D62M4I8M4I50M5D19M3D11M2I53M4D7M2D32M2D57M3I48M2D11M4D15M1I23M2D16M5I7M1I3M1D27M5D4M1I18M1D79M5D1M5D8M5D20M1D22M5D24M2D30M5D43M1I17M1I22M2D18M3D1M4I15M1I4M3D1M3I22M5D62M4D19M3I3M5I7M2I110M5D7M2I9M4I28M2D3M4I17M1D1M5D103M5D45M3I32M3I37M1D20M1D22M5I6M3D101M1D20M3D6M1D15M5I14M5D118M1I3M1D3M5I37M4D10M4D10M1D10M2I48M1D2M3D7M4I60M1I38M4I16M3I20M4I30M2D3M2D15M3D35M1D7M1D1M1I44M4D6M5I1M2D2M3I83M3I3M1D18M2I1M5D65M2I13M3I25M1I10M2I23M2D12M1D10M1I1M4D8M3D27M5I9M1D11M3I69M4D115M1D28M5D38M4I5M5D21M4I11M5D43M4I70M5I38M1I27M2D8M3I2M2I10M1D94M5D17M2D9M4I21M1D2M5I8M2D32M4D52M1I37M3D7M5I64M1I31M2I21M2I11M4I46M4I5M5D22M1D55M4I18M3D102M5I72M4I4M1I7M5D19M1D40M2D101M3I2M1I36M2I26M4D5M2I29M5I13M5I20M3I9M2I8M2I143M1I10M4D25M5I41M1I9M5D12M2I8M4I11M2D66M3I1M5D77M5D4M2I49M4I15M3D11M4D17M5I143M2I29M4I4M3I4M3I19M3I44M5D108M3D12M2D19M1I13M3I18M5I2M1I16M1D4M3I318M4I39M4I21M1I24M3D32M2D70M5D11M5D34M4D46M4D3M3D32M3D54M2I8M1D65M5I53M5I27M3D6M1I34M5I34M5I37M4D1M5D10M5I68M1I8M4I6M1I14M5I6M5I26M3D50M2D2M5D22M4I34M1D24M1I28M4D67M2D43M4D17M4I57M3D35M5I66M1D45M2D27M3D28M3I32M4D24M1I16M2I3M3D6M4I33M4I12M2I19M2D5M1D119M3I64M5D29M3I87M2D4M4D42M4D3M4I76M2D19M2I51M2D18M1D2M4D21M4D11M1I6M4D135M1D10M1D120M1I102M4D37M5I8M2I51M4D50M2D14M2D32M5I2M5I36M4D59M3I87M1I21M2D14M1D27M5I3M5D4M4I90M1I37M5I19M3D12M1I21M5D51M4D3M4I8M4D28M4I76M2D5M3I13M4I214M4I18M1I22M2D12M2D123M5D9M1I9M2I17M1I7M5I70M2I34M1D13M5I2M2I69M4D129M5I64M2D15M2D9M1I56M5D73M1D45M5I55M3I26M2I24M4I31M2D29M5I2M2D80M3I28M1D19M4I1M5D4M3D118M3D36M2D32M3I1M2D35M2D27M1I32M2I7M3I51M1I51M3D21M4I4M5I40M1I27M4I55M1I16M4D50M1D107M5D96M1I4M1I68M4I4M4D4M1D78M1I5M2I73M1D7M5I21M4I8M5D71M5D19M5D20M2D7M5D27M1D35M5D38M4I83M1D33M4D54M4I19M1I3M2I11M4I4M1D10M5I24M3D1M2D12M4D8M5D1M2I22M2D39M2D101M4I4M4I26M5I13M3I26M4D33M5D10M2I13M3D19M3D18M2I27M2D3M2I2M4D33M3D55M4I6M3I129M1I14M3D41M4I3M5I81M5D9M5D12M2I5M3D1M5D40M5D2M1D21M1D4M2I2M4I12M4I22M3I105M4I1M5I14M3D19M5I6M4I13M2I10M2D11M4I34M2I7M2D32M3I13M5D23M4D8M3D59M5I11M3I53M1D19M2I122M2D15M2D108M5I1M4D14M5I11M4D12M1I19M2I1M3D7M3D4M2I1M5I24M2I15M1I36M3I16M3D25M5I3M4I22M5D6M4I22M3I77M5I43M1D13M3D30M5I19M4I29M2I86M2I23M4I9M3I7M1I14M3I3M4I39M1I77M2D5M4D58M1D1M1D4M5D57M5I22M3I84M1D19M3I14M5D21M4I10M5D17M1I4M4I63M2I23M4I23M4D32M5D40M5I29M4I126M3I2M1D105M4I49M1I32M4D29M5D31M1D15M5I6M5I21M4I56M2I6M3D11M4D3M1D28M4D78M1D5M1D20M3I67M1D2M2I7M5I2M4D14M5D4M3D27M2I18M5D20M5D58M3D19M4D36M5I133M3I75M4I39M3D28M3D158M4D8M2I12M5I68M5I18M2D17M4I52M1D90M5I17M5D47M4D3M2I15M3I4M1D17M4D1M3D23M1I84M5I1M4D10M1I11M3D78M2I3M4I2M5D13M5D21M2D24M1I89M4I2M3D59M4D22M5I14M4I16M2I53M1I13M1I81M4D11M3I29M2I170M2I43M5I116M3I1M5D1M2I20M5I51M1I17M3D2M4I5M3I17M5D36M5D21M3D4M2I85M2I18M2D42M3I48M3I7M4I11M5I17M4I3M3D45M1I93M1D38M5I8M2D41M3I56M2I35M5D59M5D36M3D9M5D23M4I12M4I14M1D38M5D6M1D2M1D2M3D126M1I9M2D31M5I81M4I7M5D19M5I25M3D222M2D29M2D105M1D39M1I4M2D7M2D67M3D32M5D3M3D36M1I50M2I117M1I75M1D24M2I80M4I48M1I11M4D4M2D55M4I21M5I29M1D51M3D16M5I43M3I17M3I6M4D99M3D17M3D22M3I18M5I35M3I28M1I23M4D9M1I46M3I16M4D18M3I32M3I16M1I60M4D76M3D1M3D9M2D28M2D25M1D8M1D1M5D56M3I8M4I33M1D15M2I83M5D60M5I99M4D90M4I69M4D41M1I4M4I1M3I50M3I38M2D80M2D56M4D33M3I8M2I11M5I15M3I42M1I135M2D29M1I34M3I13M1I74M1I10M5I48M4I8M2I74M4D6M3I43M2D3M4D99M2D20M3D35M5I12M1I4M2D25M5I68M3D57M3I24M5D8M5D10M3D84M5I170M3D31M1I9M3I7M2I47M1D31M4D7M4I13M2D7M4I7M2I58M1I81M3D18M5I6M5D68M4I18M1D25M2D1M2I7M4I5M1I14M3I75M2D33M5D17M1I19M2I3M5I5M5D53M3D1M3I33M1D27M5I33M1D93M5D1M3D167M4D38M2I33M3D119M4I43M3I31M3I7M1I77M5I5M2D5M5I24M4D10M4I88M5D47M4I29M4D63M1D11M2I41M3D97M3D13M4D48M3D55M4I3M5D32M1D53M5D13M1D7M2D23M4D131M4D17M2D18M4D4M2D6M1I71M1I29M5I12M3D48M1D45M4I41M1I84M5I84M2D17M5D87M3D88M2D14M5I52M5D62M4I39M2I44M2I26M4I15M4D21M1I8M3I21M4I48M4D34M4D29M4I17M1D18M5I91M1I35M4D4M2I10M4D26M2I4M1I27M4I14M2D11M3I35M5I64M2D86M1I119M5I23M4D27M4I70M5I8M1D12M3D17M3I9M1D77M3D29M1D35M1I37M3D7M4D35M2I13M3I9M2I112M1D19M4I20M4D81M5I129M1D3M4D48M4D31M4I73M5D18M4I8M2D15M5I18M4I33M5I112M3D13M2I26M5I21M3D1M1I63M2D1M3I22M5D5M4I18M2I10M3D7M1I34M3I1M4I2M5D56M3I48M4D13M3I26M5D24M5I7M5I13M4D16M5I44M1D60M1I17M2D18M5I4M2I1M4I4M4D40M5D81M2D19M3D4M1I19M4D10M4I9M5I7M2D51M2D13M4I19M1D57M2D58M3D84M3I2M1I24M1D11M1D3M3I47M2I9M2D5M2D65M1I25M2I35M3I45M3D1M5I13M1I34M3D5M5D2M4D30M2D21M3I6M1I69M4D69M1D9M3I61M4I3M4D16M4D47M3D28M3D14M2I85M2I33M4I9M4I48M4D78M5I73M2I5M1D60M3I31M4D1M5I24M2I32M4I14M2I19M3I5M2D22M2D49M3D5M3D11M2D43M4D4M1D10M1I14M3I3M5I19M5I63M3I4M3D32M4I1M5D18M1D17M4D41M3D25M1I20M3D43M2I21M2I19M3D2M3D17M4D30M5D30M4D9M4D6M3D51M4I58M2D23M2D4M1I19M1I12M2D20M2I1M3I42M2D82M3I3M4D33M2I37M5D65M1I82M4D6M1D54M5D11M5D34M4I7M3I17M5I33M5D38M1I31M5D26M1I16M4D20M2I13M5I23M1I11M1I10M4I4M3I7M3I26M3D30M5D3M4I35M3D1M5D14M4D24M3I23M4I7M1I32M1D29M3I14M1D107M5I6M5I6M4D3M1I41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53M1I23M5D33M1I25M5D4M4D43M3I41M4D6M5I75M4D61M2I39M2D58M4D56M1I19M2D4M5D103M3D30M2I19M4I10M1D6M2I20M2D10M5I42M5D5M4D61M1I97M4D6M4I71M1I71M2I28M2I5M4D6M5I39M1D9M3I33M4D6M4D28M5I37M2D22M2D97M5D9M2I63M5D8M5I14M2D2M5D15M5D55M2I155M5I95M2I48M3I15M3D5M3I6M3D56M5I13M4D3M2I10M5D4M1D72M2I24M5D1M3I18M4I103M2I37M3I53M5I14M5I20M2D47M2D26M3I50M4D11M3D3M1I86M2D45M2I53M1I48M1D3M4I4M3D2M1D12M2I51M2I6M1D22M3D24M4D43M4D16M5I1M3D4M5I74M4D10M5I7M4D12M5D25M2D133M3I136M5I1M1I2M4D1M1D64M1I12M4D48M2I48M3I57M1D56M1D3M3I54M4D21M5I68M4I32M1D21M4D46M5I14M4I8M3D20M5D15M2D175M4I10M5I10M4I15M4I46M2I3M4D5M1D23M5D26M3I29M5I9M5D31M3D22M5D13M3I29M2I74M4I12M5I71M3I97M1D10M2D106M2D23M3D5M4D37M4D13M4D95M5D6M3I6M1D22M5I29M4D9M5I43M2D2M1I30M4D18M5D46M2I25M1D14M4I23M4I3M4I21M1D20M1D5M1I19M1I65M1I5M1I3M4D74M5I66M1D40M4D4M5I60M4D21M3D2M5D11M1D12M3D9M4I41M2I54M4D14M4I12M2I8M2I5M1D12M3I14M3I4M2I60M5I19M2D10M2D7M5I42M5I12M5D7M5D104M3I22M2I11M5D17M2D11M5D24M5I2M1D89M4D12M3I66M4I12M2D19M2I115M5D47M3I7M4I26M1I42M5D83M2D4M3I27M5I66M3I87M1D42M4D13M2I28M2D11M1I49M1I1M4I29M2D41M1I4M1I23M1I4M2D3M3D78M1D35M2I13M2D52M4I51M1D135M4I97M2I20M5I12M3D80M3I35M2D25M1D14M4D73M4D9M3D37M5D14M4D13M1D49M1D29M5D59M4I13M2D10M3D17M2I11M4I5M3D44M3D47M5D36M4I2M3D28M4D96M3I39M2D25M2D42M4D68M2I65M5I123M5I25M4D15M5I53M2I40M2D15M3I31M1I5M5I45M1D1M1D19M4I4M3I32M5D20M4I73M4D4M2D44M3I20M2I73M3D10M4D7M1D2M2D5M1I10M1I176M2D20M2D80M2D22M3D103M3D67M3D60M1D45M3I11M3D10M4I29M4D20M2D26M1D27M1I61M2D3M4D31M3D36M5D54M1D83M3I34M2D7M2I30M5D93M5D8M4I18M3I96M1D19M3I8M5D29M3I33M5I76M4I40M2D4M2D1M3D4M2I19M2D3M1I10M5I57M5D38M3D32M4D3M2I8M1D9M5D204M5I19M5I21M5I21M3I5M3I12M4D34M1D1M2I19M1D13M2D4M5I6M2D34M1D37M2D11M2D58M3D8M3I10M3I30M4D4M5D58M3D29M3I15M2I21M1I26M1D69M4I10M1D46M4D12M4D8M5I29M2D7M5D1M3I104M4D27M4D34M4I20M5I22M3D51M1D2M5D21M4D16M3I148M5I47M4D16M1I18M2I12M3I95M4D8M5I13M1D89M3I57M5I5M3I31M3I117M2D69M3I8M3I16M1I62M4D39M4D50M5D36M2I6M5D122M3D43M1D42M5I23M1I48M3D47M1D23M1I38M3D59M5D3M3I12M1D8M3D46M1D25M1I2M3I6M2D15M2D6M4D11M1I39M4I57M4I21M1I20M2D61M5D52M2D52M1I4M4D29M1D15M3I66M3I7M5D11M2I25M2D25M4I68M3D40M4I49M3D134M4D44M5D18M3I14M1D1M3D7M1I19M2I8M5I19M5D51M2D11M2I20M2I33M1I6M1D9M5D3M3I91M2I11M3I15M3D66M2D5M4I2M2D3M2I78M4D13M5I6M1I26M4I34M3I76M5I7M3I120M4D48M1D75M2D18M2I40M2D23M5I3M2I40M1I18M5I23M5D15M3D32M1D21M4D46M3D42M5D95M4I5M2I53M5I16M4D36M3I69M1I73M1I17M4I9M3D20M5I9M3D24M4D84M5D13M4D88M4I20M3I1M4D4M4I42M4D17M5D20M2I13M4D17M1D27M4D61M3I25M4I6M5I10M1D26M2I38M5D64M3D92M2I33M3I50M2D77M1I27M1I8M3D16M3D8M4I33M5I97M1D41M3D18M2I21M5D44M4D41M5D6M4I8M4I12M2D8M5D10M3D73M1I31M1I17M3I6M4I2M4I39M5I26M1I61M1I13M2I42M1D43M2D19M5I6M5I16M2I31M5I27M1I7M4D2M1D3M2D83M5I5M2D27M5D23M4I10M3D69M1I1M2D56M2D15M3D65M2D23M3I10M3I25M5I65M1I8M5D5M5I255M4D3M1D91M3D40M5D3M3I17M4I106M4D27M4I10M5I7M1D31M2D32M1D51M2D36M1D12M4D3M5D3M1I74M4I110M3I9M4D20M4D4M4D18M3I20M3I44M2I1M1D10M2I17M3I48M5I7M4D27M1D29M4I6M4D9M5I40M4D32M1D86M1I1M2D6M4I21M2I27M5I11M2D22M2D21M1I31M1I123M3D29M3D23M3I13M1D23M5D6M4I11M3I38M2I16M3D5M1I26M5D15M4I116M4D9M1I4M5I20M1D61M2I15M5I7M1I35M1D68M5I13M1I17M1D22M2D1M2D80M5I37M3D5M4D5M1I43M4D13M2D13M2I22M2I75M5D17M5D8M2D41M3I53M2I17M2I9M2I109M2I3M4I39M2D82M2D39M3D31M2D55M4I11M3I17M4D32M1I1M1D35M3I1M4I45M5D75M1I92M1D58M2I16M5I4M3I9M4D2M5I117M2I30M3I14M5I5M1I12M2I8M1D1M3D38M3I28M5D71M1I38M4D105M2D18M3D8M4D89M4I17M4I25M2D5M4D19M2I37M4D44M4I25M3D6M4I45M4D35M1I3M5I29M1D28M1D17M3I10M3I115M2I50M3I6M3D58M4D20M3I34M3D25M2I13M5D15M2D59M2D78M1D4M3D55M2I43M4D1M3D13M3I39M4I4M1I34M2D16M5D133M4D15M1D63M1D29M2I9M1D16M5I45M3I35M1D15M2D50M1D24M4I3M5D9M3I4M5D40M1I33M1I10M3D8M1I28M1D34M5D128M5I7M2D55M1D112M5I1M3D23M2D17M4I3M2D91M1D44M1D20M3I31M5I5M2I6M3I38M5I27M4I37M4D47M1I17M3I13M4D21M4I12M5I20M1D37M1I17M5D35M5D21M1D9M2I21M1D21M5I6M5D294M3I23M2I24M2I9M3D33M2I1M1D4M4D39M4I27M1I7M5I8M3I35M2D3M4D31M2I52M5I9M4D42M2D45M4D33M1D2M1D17M5I96M3D10M3I28M4I4M4D25M1D2M1D42M3D12M4D4M2I29M5I33M3D11M5D21M3I58M5D3M3D33M5I1M3I47M3I42M5D7M5D8M3I12M1D1M5I6M3I159M2D5M1D38M1I2M3D42M2I77M5I30M4D2M4D3M5I1M3I30M4D25M3I24M1D26M2D26M3D21M2I4M5D16M5I36M4I22M2D10M2I210M2I19M5D41M4D7M5I85M2I29M5D105M3I31M3I3M4D5M3I5M2D19M5D83M3I34M3I6M2I7M5D61M3I102M3D9M1I27M2I20M3I30M4I6M5D5M3I9M5I83M5I35M2I1M2D78M3D7M1D45M5I43M1I11M2D3M3D14M2I68M2D66M1I7M2I2M2I3M4D18M3D29M4I6M1D9M5I13M5I13M3I47M2I24M3D2M3D9M4D9M1D64M4D29M1D11M4I56M3D3M1I56M3D102M3D28M3I23M3D52M4D126M3I44M2D33M3D162M5I22M3D54M5I43M3D18M4I56M3I18M1I5M2I39M1I11M5I60M5D22M2I18M2D76M1D50M3I31M1D49M3D116M3D60M3D24M2D25M5I10M4D1M3I29M2D103M1D8M2I67M1D46M1D2M3D65M2D26M3D4M3D14M1D10M1D15M5I27M4I8M3D9M4I21M4I28M5I38M2D10M5I2M2I18M5D8M1I4M2I22M5I85M3I32M2D3M3D14M1D15M5D68M2I3M4I51M4D2M3I4M2I24M4I4M2I10M2D7M1D51M3I1M1D1M2I23M1I2M4I5M5D6M4I33M1D75M2D7M1I25M2I4M2D33M4D35M5I70M2D50M5I22M3D79M2D28M4D9M5I16M1D26M3D19M3D57M1I87M5D12M3D111M3I18M2D47M5D2M4D6M4D9M5D42M1D112M4D8M3I54M2D1M3D41M5I8M1I14M1D15M3I6M2D5M5D14M2I15M2D8M3I4M5I19M5I45M3I39M5I15M4I25M2I18M4I10M1I105M2I7M5D27M4D3M1D1M1I16M4D2M2D21M3I6M5I68M2I31M1D61M4I23M2I14M2I8M1D105M2I13M3I20M3I52M3D61M5I8M4D7M4I14M1D15M1I11M1I12M4D25M3D1M1D31M5I5M3D1M3D83M2D27M4I14M1I1M1D21M1D45M4D58M1D3M1I50M5I8M4I67M4I25M5D18M4D60M1I11M2D33M4I4M3I2M2D48M1I110M4D2M3D29M3I2M1D48M5D14M4D62M3D45M5D21M3I18M1I17M1D5M4I31M4D58M4D35M5I27M3I4M5D93M5I155M5I16M5I53M1D27M2I2M4I17M3D34M5D32M2D64M5I20M2D52M1D33M1D83M5I6M1I40M5I3M5D37M5D3M4I37M5I6M5D1M2I99M3I28M2I23M2D4M1D121M1I50M3D30M2D1M2I80M4D20M5I45M4I64M4I20M4D17M2D8M2I51M2I32M1D14M4I3M2D143M1D3M5D1M1I36M3D1M1I64M5D47M4I8M1D12M2I43M1I119M3D61M1I106M3I27M5D3M5D71M1I18M3I1M1D20M2D29M5I32M4D10M5D18M3D31M5D77M4D10M5D27M5I26M2D6M4I43M2D43M1D15M1I6M3I71M3D65M4I40M2I27M4I17M2I95M5I7M2D177M3D47M5I3M2I4M3I24M3D10M4I38M1I45M1D11M2I40M2I15M5D77M3D41M5I130M2D34M1I32M3I13M3D23M3D18M1I21M2D55M * 0 0 GCCTACGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAATATGCCTAAGCCTAGGCCTAAGCCTAAGCCTAAGCCAGCGTCAGCCTAAGCGTAGCTCAGCCTAAGCCTAAATGGCCTAGGAGCCTAATGCCTAAGCTGAGCTAAACCTAAGCCTAAGCCTAAGCCTAAGCTAAGCTTAAGCCTAAGCGTAAAGCCTAAGCCTAAGCCCAAGCCTATAAGCCGAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTCAGCTTAACCTAAGCCTAAGCCTAGGCCTAACCCTAAGCGTCTAAGCCTAAGCCGTAGTAAGGCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTATGCCTAAGCCCAAGCTCTCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAAAGAGATAAGCAAACATTTTATTTTTTCAAAATTGTTTTCATGGTAAATTCAAAACGTTTTTTTTTTAGTGAAGCTTCTATATTTGGGGTACCTAATTTTGCCTGCACCTGCCTTATGCTCCTGTGTTTAGGCCTAGTACTTGTTTAAGATCCTAAACCTAATACTAAGTCTAAGCCTAAGACTAAGCCTAATACTGCCTATAAGACTTAAGGCTAAGACTTAGCCTAAGACTAAGCCTAATACCAAGCCTAAGCCTAAGACTAAGCCTAAGCCGAATAAGCCTAAGCCTAAGACTAAGCCTAATACTAAGCCTAAGCCTAGAACAGACTAAGCCTAAGACTGAGCCTAAGACTAAGCCTTATACTTAGCCTAAGCCAAAGACTCAATGAATAGCCTTAGCCTAAATATCTACAGCCTGAAACGCCTGGTAGTACACTCTTCTGAAAATACAAAAAATTTGCCATTTTTATAGCTAGGGCACTTTTGTGTCTGCCCATCTAATATAGGCAACCAAAAATAATTGCCAAGTTTTTGATGATTTGTTGCATATTGAAAATAAACATTTTTCGGGTGAAATGAATATCGTAGCTACAGAAATGGTTGTGCACTCATCTGAAAGTTTGTTTTTCTAGTTTGTTTTCTTCGCACTTTGTGCAGAATTCTTCTTGATTCTCATTGCAGAAATTTGCAAGAAAATTCGCAATTTGTATTAACAAAAATTGTTCAGTGAAAATTTTTGGAAATTAGTTTACGAATAAATCTCACATTTTTTATAGAAAAATTATTTTTAAGAATTTTTCATTTTAGGAATATTGTGCGTTATTTTAGAAAATAGCTAAATGTGATCTCTGTAATTTTGCCTGCCAAATTCAGTGAAATGTAAAAATCTAATATCCCTCATCACGTGCGACTTATTCCCGAATCAGCAAATTTTTTCAATATGATAGTTTGACATCAATAATTTGCCTATATAACTTTAGACCTGGAGTTGGCTATTAATGCCAAATTCATGATATCTAGCCACAACATTCGTTAGTAGAATTGTTGTTAGTGACGAACCTATAAACAGATTCGTGTTTTCAAGAAATTTTGCTATCATGGTTTTTCTTGGTCTTTTAACCTGGTATTTCGTTTTTGACAAAAATTTTTGTTTCTTGATTCTTGCAAAAATTTTTCCCTCACGACGGCCTTGATGTACCTTCGAAATACTACATCTTCTGGTTCTAATAGTGTTCATTGTTTTATATAAATACTTATTTAATAGGATTTCGGGTTATATAATTTGTATAAAGAGTGGTTGACATAACAAGGCTGACGAAACTTTGTGATGGCTGAAAATATTTTCGTAGCTTTGTTGATTTTTATTTATCGTGTTTGAATAACGTGTCCAATCGCCGAGAAGGAATAGAATACTGGACGACATTGTACGTATTATCCAAAAAATCAGAAAGGTAGATGACGGCACCACAATTCTTTCTGTCAGGTTTTACAACCGCCCAGTGCGTGTCACATGTTCACTGTATAAATGGTTGTACACAATATGCGGAAATAATCTAATGCATTCCAATAAGGCATAATATAAGAGGCTATCAGGCAATGCGTATCGCTCTTTGCTTTGTTTAAAGGGGGAGTAGAGTTTGTGGGGTCTATGTTTCTGAGTCTAATTTTGCCCCTGATACCGAATATCGATGTTAAAAAATTTAAAAATGTCAATTTCCCTCAATGATTTTATATTATTTTTTAAAATCCGAAATTCCATTGGATGCCTATATGTTCTAAACGCAAAATTTTCGCAGAGACCCCTGCCGCCCACGAAACCTTGCCGCACGTGTGGGTTTACGAGCTGAATATTTTCCTTTTTTATTATTTTATACCGATTTTGGTCGATTTTTCTCATTTTCTCTTTTTTTTGGTGTTTTTTATTGAAAATTTTGTGATTTTCGTAAAGTTATTCAAACTATTTATTAATAAAAACAAAAACAACTCCATTAAATATCCCATTTTCCGCAAAAGCGAAGACTAGGAAAATCGCTCTGGAGATAGAATGGATCAACAATTCTTATTATATCATTCCGCTAAAAATCATTATTAATTTTCTTCTGAGAGTCTCATTGCTTAGTTTACGCCAAGAAATAAATTAAAATTAAAATTGTTCATTTTTGAAAAAAAAATAATTAAAAAAACACATTTTTTGGAAAAAAAAATAACTAGAAAAACGGATCCTCCGCGTCGAATCACTGTTTCCGAACTCTTAAAATTCAATGTTTATTGTACAACCCTTTCGCTATTGATTTGATAGCTTTTAAGTAATAGAATTTTCGATACATTAAAACATTTCACAATTAAGCTGGTTCTGAACTGTGTAGAAGTATATTTAAACAAGACTAACTGATACAAAAATATAATTATGATAGTTTTCTGGACCACGCCAATATAAACGATGATCAATCAAGGGACCTGCTACAGTCGTCCACTAACCCGAATATCGACAAGAAAAGAAGAACGCCAACTTTGGATAGACGCTCTAGGGGCCGATGTCGGAAACTAGTCGGGAAGCTAAACCAGAATAGAGGGTACATTACAGATGAGGAGGAGGATGAAGATAGAAATATGCCGACAACATCGTCAGGCCGCTGATTTTTTTGATGTTCTACGCTTAAATTTTCAGCGAACGAACTATTTATTTTGATTGCCTTTTTAAATTTATAATATTTGCCATATGAAATTCTCACTTTCAGGCTGGAAACGTAGTTTTGCAGGCCCCGTCTCCAGTCGATTTTGCGCTGAAAATGGGATATTTAATGGAATTCTTTTTGTTTTTGTTAATAAATAGGAATAAATTTGCGAATATCACAAAATTTTCAAAACACCAAAAAAAAAGAGAAAACATGAGAAAAATCGACGAAAAATTTCGCTATAAAATCAATTAAAAATAGAAGGAAACATATATTCAGCTCGTAAACCCGCAAGTGCGGCACGGTTTGTGGGAGGGGCGGCTCTGGCGGAAAATTTTGCGTTTGAAAACGTCGATTACATGGCATCCAATGGATTTTCGGATTTTCAAAATTAATATAAAATCAGGGAAATTTTTTTAAATTTTGTCACTTCGATATTCGGTATCCGGGGCAAAATTAGAGCAGAAACATAAATTTCCCCAACTCTATCCCCCTTTAACAACCAACGCACCCGAGGATATACAAGCGTTCTATCTACTAGGCATAACTCGATTATTGACATATTATAGACTTCTTTTAATATTTGTAAAATAGTGGATCAGACCCAAAATTCAGCCCGCGAAGGCATGACGTCAGCACGGAGGAGTCTTGTAGTTTCCAGAAGAACTCTGTCGTCTACCCTAATGCCTTGCGAACCCGGGCCATCCTTTCGCTCAGAGGAAATGGATTAGAGTACTCATCAACTCCTCTGTCTAATTTTCAACTGCGGGGGCGACCGTACTGTATTACCGCGGCGACCGACACCTCCCGCGTTCCGTCGATCGCTGTCTGTTGTGTGCGCCTGCGACTCCGCCCACCGGTGGTAACTTTTTGTGGAGGAACAATTCCTTGATTTTGGTCAAGGTTTTTCTGCGCTTTTCAGCGTATTATTATTGACCAATTTTGAATAAAATTTTCAAGAATCATCTAAAATATTTAACATTTATTTAACATAAATAACGTGAGTACGCAGTAAAACTTGACATTTTCAGGAAAATTGCAATTAAACGAATAAAAATCGATATATCCATCATGTTTGGTCGTGAATCCGGTGTGTTGAGCCTACAATGCATACATTTTTACTGGATAAATCTCCTTTGGGAATCCGGTTTGCAGTGCTTTCGAAATGACATGTCCAGTTGAGAATCGCAGGCTCTAAGATGCTCGGGCTGAATAATGAATTGTTTTAAAAAATGTTTAGTAAAAAATTGTTTTCGAATGCATATTGGCTTAACCGATATTATCCAAACGTGACGTTTTCGCGATTTTCGCGCGCTAAAATTACAGTGAGTGAGGTCGACACGACAATTTTGTAAAATTACGGGCGTTCTTTAAGAAGTACTTTAGTTTAAAAAATACACTTCATTTCGTGGAATTTTCTGAATATATTTTTCATAGTTTTTCTCTTTAAATAAATCACTTTTCAACAAAAAACTATGAGACAATAGTTTGTACAGTATTCTTTAGAGGGGCACGCCTGCTCGAATTTCGCAAAAACGTGTCGTGTCGAGACCCCCATTACAGTATTTTTGAGCCGAATATCGCGAAATTTCAAGTCTGGGTGAAACATTGAAATTTTTGGCAAAATAAAAGAATCCTCTTTCAGAATATATTTTGTAAATTTCGAGACGAAATGTATACCTAAATGAATTTTAATTTTAAACCCCTATTAAATATTATTTGGCGTTTTTTATGCATGTCGATTCACTAACGATTTAGTAGTAACTACACGTGGGCAAGTTTATACAGTTTTTGGCTAAGATTTGTGAATTTGAACCGTTTTTCGGCGAACATTACACATGAAAAATTGGCAAAACGGGTTCAAAAACAAAAATTTTGTTAAACTGTAAAAACTGTCCAAAAATTTCGTAAATAACCGGCACACACCCTTTCATTTTTTCAAAATTTTAATTGTTTTCGAATGTTTTTTTTGCAGAATAATTTGTAAAATGAGCCTTTTGTGAATTTTTTTTAATTTCAAAGTTTATTTTTTCTCAAACCAACCCCTGTTGTAACTCGTCCAACTATGATCATCACGTACTGTCGAATAAGTTTCTCGTGATTTGTCACATTATCCTTGAGCTACATCCGCCAGGTTTCAGTCCTTTCTGAAAATGAAAATTAATTTTAAACAATATTGAATTATTTTAAATGAAACAGTTTTCAGAGATTTAACCTTTCGTTCGAGTCCACCACCAGGCCTGCACGTTATTCGGGTGTTATCTTTTAAAAAACTGAAAAATCGAAAATAGTTCAATTTCTGTTTTGTGGTCAAAATTGTTCAATTACAGGTAAGCAAATAGTCTTTAATTTTCAAGTGAATTGAAAATTAGGGAAATGACCGGACATAAGTTTAAAAACCCGATTGCAGTTTTCAAAGGTAAATTGAAAATTTAATAAACAGGTTGTAAATCAAGGAGATCCTATTGAATGAAAAAAAATCCGAATGTGCCGACGGGATTTTTCGGTGGTTTTTGAACGAAAATCGAAAAAGTAAATGTTTTTAATTTTCAAATTTCAATTTTTAATCGGAAAAAATGTACGAAATTGACTTTTTCATGTGAAACATTGTTGTTTTCTAGTAAAAAAAAATTTTAACCGATACAGATTTTCTAGACTCAGTTTTTTCGGTTGAATATTGTTTTTTACTATTTTATCTTTCTATTACAGATACAATTTTATTTCGCTTAAAAATAACCGGAACATCGAAAATATTTTTTTTTCTGTTTCTCAAAACATTTCAATTACCTAGAATTTTGTTTAAAAACTACATGCTTTATTTATGAACGTAGTAAATAATACCCCCTCTTATTTATAAACTTTCAACATACAATTTTTCAGTTTTCAGTGCTATCTAGTGCTTACCGCACATCACTTTTAAAGAAATCAACCAAATCGTCACCAAATATGCCCTGAAATCCATTGAATCCATAACAACTTTAATCATAACGTCGTTCGTTTCGGGCGGTGCAAACGTCTTTGGCAGTCCTTCGCTACGAATCATTATCTCCAATTCGTGGATGTTTTCCAATATATTGATCACTTTTCGTGATCAACTCCTCGACAACTTCTTCCATATCAACTTTCAATAAGAATGGCATTAAGAGATGCTTTGTAACACGTCCGATACCCGCTCCGCAGTCCAGCTGCATAGTCAAGCCGAATAGATTCTGGAAAATATTGTCATTGTAAAATTCAAAGTTGGCCCAGGGGTGACCGGCAATTTCACAGCAAATCGTTGTCAATTTTCCATGAATTTGATGCCCGAAAATTGGAAAAACGACAATTTGCCGGTTCGCTGAATTTACCTTTTTTAAATTTAATTTTCAATTCAGGCAAACGCTTTTTTCCGTTTGCCGGATATCAATTTGCAGGAATTTCTCAAAGGAATTTTTATTAAAACGGAAACACAGTGCTTTTTTTTTTCTTTCCCGTGTTTTTCAGATATTTTTATAAAGTTTACTGACTTTTCAGAATGGTGAGATGTAGGACAATTTTGTTTTAAAAAAATTGTGAAATTTCCAGCAGAACAAAAAAACATGTGCAAACCCACAAGTTGGCAAAAATATTTTGCATTTGCCGTTTTTCCCGTTTGCCGAAAAGTCTAATCTCGGTAATTGCGCCATTTTTCGAGATTTTGAGCCACATAAAAAACTTTGAACCATTTTTGAGTTAAGTATTATTACGACATTCGTTTATTTGACGCTGCACGAGAATTTTATGGGCCTATACCTTCAAAATTGTCGGGGTTTGAAAACCCCTATATGTTCGACCGAATGTTAATCTCACTTTGATGAAAATAAAATTTTCTACGGCTCATAAACGTATAGCCGCCGTCAGTCTCAAAATTTATACGATAGACACTTTATGGCGTTTATCGCCTATATTCCGTCAACAATTATTCATCTCTTTCAATGTTGTTTTTTTTTAAGGCTAAAAATGAACTTTCATGCAAATTTGTTTGATTAGGCCGTGTCGTGGTTCAACGATGCAAATTTCAGAATTTAAAAAATAAATGAAAACGAAAATGTTTCTATATACCCTATTTGTGTTCTGTGATTCCGAATACCACTGTGAAAAATTCAAAAAAAATGCCCTGATTTTATATAAATTTTTGTAAGCGTCTACAATTGTCGTTTGAATATCACACTTGGTTACACAAAATTATGAAAATGAGGAAAATTTGTTTTAATTTTTTCACATTGATAGTCGGAATCAGGAAAAAAAATAAGGTCTATAGAAAAATTCCGAACCTTTACTGCTTCTCTGGGTATAATAAATTTAAAATAAATACAGAAAATTTCAGTTCACACTGACCTAATTAAATTTGGGTATATTTCTAGGATCCGAGTTCTTGTTTACACCAGATTTACAAACTATCTAGCCTTTCACCGCCTTTTTATCATTTCCCTTCAGGCAACTCCATAAAAATCGCCTTTCGCCTCATATTACAAGATTATTCCCCTTTCTCTCCCCATTGAAAGTCATTTTCGAAACAAGCGGAAGTCATATGTGGTGTGGTGTGCGTTGGCAAACAACAAGAAAGAATCTCTGAAAACAAAAAGCGTTTTGGGTGCCCAAGTAATATTGAAAATCGTGTCTCATTTTCCATCAAAAGAAAAGGAGAAAAATTCGGCGTTTTGTTTGATTTCCGGGAAAGAAGACTCGGAAAAAGATTTAATTGACTATTTTTCAAGCAAACCTATATTGCTACAACTTTCTAAAAGGTCAGAAATTGCCGCGTAGCCTAGAAAATTGGAGGTTTAAACTCTTCCAGCTGGTAGTATTTCAGACAGGGTGCATCGAAAATTCGAAAATCCTCCTACAGAAATTAACATTTTGAAGCATCTAGAAAAGTTGAGATTATAGTACCTCACTTTTGCCGAGAAATCTCTTTCGAGGTTGAAGAGGTCTTACAAAATTTTCGGTCCTCTGACGTGAAAATGGGATGGGTTAAGGCTTCACACGACGGCGTTTTCAGGTCACACGAGAAGTTATCGTACGAGGAGAATTGACCTCCAAACCCTGATCGTGACTACAGGTCGTCGTTCGGAGCATGCGGAAGGTTCAGTGTTCGAAAATCTTCGACCAGCTTATGAGACCAGCGAAATAGACAGGACGACCAAACATTTGTGGAAGAGCTTTTCCTAGACCATCAGGATGCTATTTCGACAGAGCTGAGATAGTCGTTACGAAGTGTGGAAAAGCTGGTTTTCCAAAATCCCCGACCAGGTAGAAAATGAGACACCGATTAAGTTTATCCAGTGGGTAGAGTTTTTTCTAGGCCATCATTATGCTAGAAAAAAGCTTCGGCCATGGGGTTTTTAGGCCGTCTATTTATTTCTCATCACTTTCTCAGAAATTTCTATTTCTCAGCACCCCCCAATGATAAGTTTTTTGCAAAAAACTGCTTTGCTCATCAGCAATTCGTAATCAGGTGACCCCATTAGGCCTACCGAAACACACATTTGTCATTATTTTTCCGAATAACAAGAAAAAAGTCTTCACGCATGGGGAGATAAGAAAACCTGATTTTAAATCTTACTGTGCCGGCTGGCGCGGCGAGCTTCGATCACTGAGCCGAAAGATTAGAAAACTATGGGAATGAGGGCGTATCGTACAAATCGTCCAGGCAGAATCTGTCTAATTTTCGAACGTATATCCAGTTTTGTTATTAATTTAAGTAAACCCGTCAAACCTAGAAACAAGTAAAACGGGAGGGGGGGAATATCAGAAAATTAAATCTTGCGCACACTTTTCCATTGATCTACTAAGGTATACAATGCCCAGAGGTGTGCGGCAAATTTTGAAACTTACCCGCGCATGCCGCCCGTTTTTTTGTTTCTAGAAAAGTCAGATTTTTTGTCGAATTTGTTCAAAATTCGCTAAGATACTGTGAGTTTAGAAAAAATGACGAAAAAACTCGGAAAAGGAGGAAGAGATCTGAAATATGTAGATTTTTTTAGAAAAGACCAGGATAAATTACTGAAAAATTGGCATTTTTCGTCGAAACCCCAATATACTAAATTATGCGGATTTTTAGTTTCAAATTCAACATACAGTGCATTTTTTGGGCCTACTTCTACGACTTTAAAGGGGGGAGCATTTATGCGGGAGGGTCCTGCCGCGCATTTAGTCATCATTTTTAGCAGTTTCTGTGTAATTCAGATCACATGCAGGTCACACAATATTTATCCCATATTTAGTATGTGCCGTGCTTTTTCACAAATTAATTGTGATCTACGCGTGATCCCTGCGAATTTTGAGAAGACTTTGTTAAAAATGATGACTGTCCACGGCAAGACCCTTCGACGTATGAATGCGCCCCCCTTTAAAGTTGTATAAGTGGAAAAAAAATGCTCTAGCAAAAAATCGAACATTCTGATATTTGAATATCTCGAAATTAAAATAATTTGTGAAAAATTTTTATTTTATTTCGAAAACTACCGATTTTAGAAAAATTCTAAAATTTCGATTTTTTTTGTTGATTTTTCGATTTTTAAAATAAAATTTCATAATCTTTTAAACCGATCTCTCTTGCATTTCCTGAAAAATCGTGATTTCTATCCTTTTTCTTCAGTCCTTCAATAAATCGTTTCGACTCCGATAGGTCGGGCGCGTGAAGCGCTTCGAATCCGCCTAGCATTCCGTTGAAGTCCTGCCTCGCGCGGCTCCAGTATTCCTCCGCCCTGAGAGAGAATAGTTGAAAACATTGTTTTGAGACTTAAAAATTTTTTTTTTAGTTTTTTTCAAAAATTCTTACATGTTATAGAGTTTGTTTTTCAAATTTCTTTTTTCAGAAAAACTTAGTATTTTCGATAATTTTAGTTACAATAAAAACGAGTTTTTTTTCAAAAAATATTTCGGTTTTTTTTTTAATTTTTGGTCTAAAACCGCAAAAGATTTGCGTGTTGGCCGAACTTTTTGATTCTGTACCTTTTCAAACAACTGCAGCATTGAATTTTAGAAGATAATGAAGAGCTCATTTTGCTTATGCTCCAATGTTGCGTCAGCTGCTCCGAGCAGTCTGGAGACATGACGAAAAGACGAGGGGTCACGGATATGATGACGATACTGGAAATGAGATATTTACATTGTCTACTAGCTCATCGGGAAAATTATTACCAGAAAGATAAACAGACATGTGCGTTTTTTTAATGGAAGAGAAACACAAGAAAAATTTGGACAAACTAGGGCAGGGCTATGAGTCGATATATGGCTTCGGTCTCGACACCACTATTTTTGTTAACTAATATGGTATGGTCGCACCTATAAAGAGTACTGTAGTTTCTAACTCTCTTTGCTGCAACATAATTGACGCTCAGCGAAAACTACAGCAATTCTTCAAAAGACTATCTGTACCCTTTGTGTGGACTTACGGGCTCGATTCTCGTGCATAAACGAATTTCTGCTCGAATGATAGCCCTATGTCAATTTGGTATAGTCTTTTCTTTTGCCATTTTTCCGTGTTCTTCTAATATTTAATCTATTATTAAATTATGTAATTCTCACCCTCCTTAGAACTGCGACCGAACAGAGATTCGTCACCTCCGCCCCATATTCCGGCCAATCAGATCGAGTAGGCGGAGTTCGAAGTCGCTGATTGGTTTGAAAAGTCGCGGAAATGCAAGAAGTTTTAAGGTAGCCGTGGAAAACTGATGACTATTCTAGCGCGCTTGTGTCGATTTACGGAATCTCGATTTTCAGGAAGGAATTTTTAATTACATTTTTTCGCTCAATTAATATTCTAAATAAATAACTACATGATTTGAATTAATTTAATTTCATTCGAGCCAGTAGATCGACACATGTGCTACAGTAATCATTAGTTTTCGCAACGAGATATTTTGCGCGTACAATATTTAGTGTCCCGTAATAACTCTACTCCCTACAAACATTACGACCTCCAGAGGCCTCCAGGTAGTTGAGACTCTTGTATTTCCAATTCAGAGACAATGCGTCACTGGAAGAGAAACCGAAGCGGAAAAAAAAACACGGAAACCCAAAAATAGGGTTTGCCCCGCCCTATTCTTCTCCAATAATTGTCTTATTTTTGCAAGACTTACCACCTGTGTATGCCTTACTCGACATGCGTTAAACCCCCCCCCCCCTCCCTATCTTACAAGGTACTGATAACACTTTCAGTCTTTCACACTTTTGGCGGGGACATCGCCGCTCTTTATTCGCGGCGAGCTGATGACTCATCAATTTTTCACTCAATTCCGCTTTTGATTATCTTCAATGTTCTAGAAGGGCACATTGGTCATCCTTATTTTTTCCTTCTCTTTCTCGGGCCTTTGTTGCGCATGACCGCCCCCTACAGCAGGGCGTGGCCTGAACGGGGGCTCCGAGAGCTACTCATTCTTGCCGCGTCCCCCTCCAGCGCCACCCAAACTTCTTCGGTTCTAGAGATCGAGAAGAAGCGAACGTATGATTTTTTAAAATTATAATTGTTTCTTTCGAAAAAAAAAATTTCATTTACAGTAAGCCACAGATACAATCAACGAAACTCTTGAATTCTGCTATCTTTTCTTGCGACAGTTGCGGTTTTTGGTGAGTTTATGCTTTAGACTTTTCCGCCAAAAATACAGTTGCCGGTCTCGGTATGGCAAAATTTTTGTTAAATTCGAAAAGCAGTGAGTAAGTAGTTTCGAATTTTCGTTCCTGCTTAATTTTCATCAATTCATCGACTCATTTTTCTCACGACTTCTTCTTTATGAAAAATCAATGAGAATTCTGACTAGGTCAGGATCTTAGGGGTGAGGTACCTAGGGACGCATCACATATGCCAAACGGAAGCTGAGAGCAATCATTGGCTACAAAAATATGCTTTCAAATTGCAACGGACCTCTGGGAGACTGCAAATTCGGCCATTCTGAAATTATGCTTTTGTATGCTCGAAAGTGGTAAGAATTTAGGATTTATTACAGAAGAACGTTTAATTAGTAAAATTAGTTTTTTTATACTTGAAACAAGTACAGTAGGCCTGTATCAAAACACATTGTTGGACTTCTTATTCTACTTCATGTTTTTCTGTAATAAATTCTAAATTCTTACCACTTTCGAGCATTCAAATGCATAATTTCAGACAAGAATTTCCAGAGTCCCAGAGGTGCGTCGCAGTATTTGAAATATTCTTGTAGCCAATGATCTCAGCTTCTGTTTGGCATGTGGCGTCTCTAGGTACCTCACCCCGAAGCTTCTCCATTCCCTAGTGAGCAAACAAAATTTTGAAATTAGTACGATTTAAAGGCACATTGATTTTTCTGGGTCAAGCACAAATTTGTCGTGTCGAGACCTAGGCTACGTTAGTATTTTCGCGAAAAATCGCAAAATCTTGCAGCTGGGATATACTTGTGCGAGAATACTTTTTGCATTAATTTTGAGAAAAATTATTTTTTTTAGACTTTTTGACAAAATTTTTCGGATAGCCAATCATAAAACGGCGACCTGTGCCCGGTTGTTACATTAGGCCAACAAAGTTCCTGGGAACACTGCTGCAAACCATAATAGAGGGGTCCGGAGCATAATATCGATTTTTCGTACTTTCCTGTATTTCTTGTTCTATATGGCCGGAGTAGAACAGGATTTGAAAGTCAAAATTTTTCTCATATGGATATCACATGGATATCAAAATATTTCCATATGGATATGGAGAACATTTTTCTCCTAGGGACTTTGAAAGTTGAATCACTTGACATCTGGGGAATTAGTATTCCAGGCGTAAGTCGAATCTGTTAGAAACGGAAATGGGCATAGTGAATTAGGTAGACTTTCAATTAATCTGATCCATTGCAGTCAGACGCGGTTTCCCGGCCTGACGCCTGCCTCCAACATGCCCGCCTTCACGGCCGGTCCCGCGCCTGATTTCTGCACTGTGACGAGACAGACGAAGGTCGCCTTCTGGCGCCCGCATGGAGCACAATCGAATTGTCAGCTTCCGATGGGAGTCCGTAAATCGACACACAGGGGTACCTCAGACATTTCCCTCCCCCTTACGAATTGTTAGTGACAATTGGAGGGGGACTTCATCTCCAATCGAGACACACATATGTTGTCGTCAGTGAAGTGTAAAGATCTTAACGATTGCTGTATGATGTTAAAAAGCACTCTATGATCACCTAGGTTTTTCATCACACCCTTATTAGGTGTGGTGCCCATCGAGCACTCACGCCAGGCAGGGAGAGCACCGGTCCCTGACTAATGCGAATGTTTTAGACCGGAAAGCGATGAAAGAGCATAGAAGATCATTATCACGTCTAATTAGGTTACGGCGAAATTTGCAAAAAAGAGCAGGAAACTTGGCTCATATCCAATATAACAACCAGGACTTCCATGTAGGCGTTAAAGCGATACCACTGTATCTCACCCCAATCCGTACCTTAAGCTGAAACAAACGTGGACTTTTTTCATCTCTTAAAGGAGTTTCGTAAACGGGAAATTGTTTTAAAATGGAGTATTTGTACTTCAACAATTATTGCAAAAGAAAAACGGAAAAAATCCGCTAACATTCAGCATTTTAAGTCTCATGAAGAAGTCTTTAAAATTTCAACCGTAGAGAAATCCTGCATAGGCACGACGCTCTAGGCATTCGAATTTTAATATGTTTTGATGTTTTGAGAAAAATAATACAATAACTTCCCAGTTTTCTATAACTTTGAGAAAAAAGCGAATTAAATTCCGAAAAAACTACATTTATCAATATTTTGTTTACGAATATGGCCTAGAAAGCGCGTGGTGGCCTCGGATTCATTTGCTCGCGAAATTCAAATTCCGTCACTTTCGTCGATTTCAACGGCCCTGTAAACCCGTGCTGCATGTCAACGGATTTTTCCCGCTTATTCTTTCTTTTGCAGAAATAATTAGAAGTTTGAGTACAAATACTTGTAAAACAATTTTATTTTTGCTATTTTGACGTTGATTGATTACGGTTTTTTTGGTTTGGGACCAAAAATTCCAGAAATGTTTGGCGTGTCTAGTCTTTCGACTCGAGACTACTCTGTATTAAATAGGCAAACATTTATTTTAACACAGTTGTGACGTCATAATATTTTGATACATTTTGCAACATTACTTAAATAACCCCATTAAAAATTAACCTAATCGTGCATCAAACAAAATTTTATGGTTTTTTTGGTTTTTCGAAAATTTCAATTTTTTTTGTTTTTTGGGTTTTTTTGGTTTTTCAAAAACTTCAATTTTTTGTTTTTTGGTCCAACATTTTTTTTTGGTCTCAGCTCTTCTGGCCTACCCTAGGAGAAATAGCGCTTCAAAAACTGATGAAAACGTACAAATTTGTCGATAGAAACCAAATATTACGAAAATCTGAAAAGTTGGCTCAAATCTAGATTGGATCGGCCGATTTTCCACAAGTTTCCAAGCTTCCACAAGTCGTATCCCGAGTCGATTCAAATTGAGTTTGAATACTGCCAATTTTGAACCAAATTTCCCTGGCTTCTCTGTTATTTAAAAAAACGCGAGGCAAAAAAATAAAACGATCTAATTATTACTTTTGTGAACACAAAATTCTGAAAATCGCGCGTAAATATTGCGCAACATATTTGACGCGGAAAATATCTCGTATCGAAAACTACATTAATTCTTTAAATGACACGCTGTATGTGGTTATTTACGGGCTCAAAAAACCGACACGTTTATTTTAGAAAATGCCCGTAAATCCACACATAAGAGAGTAATTGAATATAAAAAGAATTAACCTGTAGTTTTCTACGAGATATACGCTTTGCGCGCCAACTATGTTGCGCAATACGCAACCCACCATATGGATATATACTGATGTGAGGATAAAAAACAGCAAGCCAACTTTCAGCGGTCGGCTCCGGCAGGCCTCGAGGACTGCGTCCTCAGGAGCAACTGTACAGTCTGGAGAAAGAGAACGGAGTTGATGTGAAGCAAAAGGGGCGCTGAAACCAGCAGCAGATGCCGACACATTCCTTGGATTTGTTCCATAGAAGAGAATGGTCACGTGGCAGCCATGCAGCGGTCGATGATCAATATGAGGAGTCTAGAGCTCCTTGTTATTTAGTGGTGGTGGCCGTAAAAGAGAAAACTCGGCCAAGCTGCTCGGAGTTTTTGAATTTTTGATAATCCGAAATGAAAATTGATTGCTCGAAAAGGCAATCTTTTGGAAAAACGAATTTTGTAATTTTTTTCAGCAAAAATTGCTTTTCGAATTTTTCCATTAAAAAATCGATAATTTCTCCCCGTGCAGTGGAAAACAAACAATATTTTTTTGATGATTGGCACTCTTCCAAACCCGGCGAGGACTAGGTACACTCCTGCGTCATCCCCATTATCTTATCACACTTTCTTTCGAAAATAGCGTTTGAGGTAGAGACGGAAAAGTGAGAAAGGTGAGTCAATTTTATGCGTAGATTTAGGATGATAATACACACAAATTAAAAAAACGAATGCGTGGCGTGCACTGAAACCCTCATATTTAGGCCCCGCCTAACGGTTTCACCTCTCGTCCACTCACGGAGAAAAAAATTTACGTGGGGACCAACCAATATCAGGCCTAGGCCGCCATCGTACGGGTTCCGCGCGCCGCTATGTTTAACTCTCTGTGGGTGTGGCGAGCTGTCTCCGCCCGCTGCGACTCGAGTAAAACATAGCGGCGCGCGGAACCCGTAGGAAGTCGACGGCCGATATTGTTGGACAAATTTTTTCCTTTTATCCGTCAGTGGACGACTATACAAAAAGGCGGGGCCTAACCACTTAAGATGTTTTCTGCAGTACACGCCACGAACAGTTTTTTTATGTTGAGTGTATAGGTCTAGATTCTCGAAAGTCTAACAGTTATTTAAATGATGAACTCGTGATGACTGTTAAATTGCTTTGGAAATTTCGGGGGAATTATAGAAATCGATTTTGTATCGATAAGATTTACAGGAAAAACCCAGTACCACTAATATCTAGGTATTCGATGGTAGGCAGGCGCGATTTCCTTGAGGCCTGCCTGGAATCTGTCCGGCTCACACCAAAATATGTCTATCATTTTGCTGAAAACCAAATTAAGAAATGAAAGTGTAGAGATGATGACGGAGGTCGCCTTAAGGTCAGACAGGTTAAAAAACCGATTTTAGCTATTTTAATTTTCTTAACAACCGAATTAGAAATATGCTGCTTGTCATTTTTGAGTAAAAATTATTCATACGAAAACTTCGACCAAAACCACCCCGAAAAAAATGAGGAAAATAAAGATTTTTCGAGAAAATAACAAAAAAATCCAGCAAATAGTGAAAAATAGTTCTCTCCGAGAAAAGGAGTTTAGACGCTATGAGGTAGTCTCGAAAATCATTTCAACCTAAAAGCCATAAACGGCATTATCGATTAAAATTCTCACTGAAAATCCGGTGCCCGAATTTCAGTGCTCCCCACAATCGAAGCCCGCTTGGCCGAAGTGTTGAGAGCCGGAGAACGCGGCTCGGAGTCAACCCGGAGGAAGTCCGTTTTGACGGATCTTCGTCCTCGTAATTCCAATAAATATTCTTTGCCCTACATACTTTATCCATCTGACAACTAAAATGTCAGTTCTTCTTGGCTTCAGCGGTTCTATTTGTCAAATGGTTTATTTTCCCCAGAGCGAACTCTCAAAAGGTTAAAATATTGTTCGATTACCCCTTTTTGTCAATTATTTTCTTCAATTTCTTATTTATCATTATTTTTCTAAACGAAGACGGTTGTGAATTTAAATTATGTTAATGGTCTAAACTTTCCAAACTGAATAAATTCAGCATGTTGGCACGTTTTTACAGTAGTTTTTGAGTGAAAATAGAGGTAAAAAGACAGAAAATCAATAAAAAATGAAAACAAAACTATCAATGAAAAATGGTTGAAAATCGAGCAAAAATCGTTCAAAAAAAAATAAATTCGAAAAAATAATTGCGTCGAGGAACGCGTCAGTACTCTCTGCGACTCTCACCCTTCAGCACGCGCGCCACGAGAAATGCGCAATGGCTAAATTCGCGCGGAAAATCATTTCGTTTTTCAACATTAAACAAATTCGACGAGTAAATCGCTCAATACTTAAGTAAGTATGGATTTTCAGCTCGTTCAAAAAATTTTCAGAACCGTTTTAAAGTCGTAAGGTTTTTTTTTAAATCGTCGGAAGTAAAAAAATAGCGCGGAAATCTACGGAGTGCGGAGCGAACACAGGCGCTGTAATTCAAATGGGTAGAATAGTCAAAATTGAAAGTTCGCCAGCACGACCATATTTTCAAAACTTAATGGTAGATTTTTTCGTTTTTCTTTTGTGGTATTTCGGCATTTAAGATTAGAGAGCACATTTTAAAGTAAAATTCCCCATCCAAGTCGCACTCACCTTCTCCAGCCATTTCCAATTGGAAAAGTGTATTATATCCCGTCTTTTTTTTTCTGAACAATAAATTTTTCGTTTATCCAGGATAGTCATGATACAAATTCGTTAACAAAAAATGAATAAATGAGAGCGATTAAAGCATTGTCGGAAAATATGGGTTAAGGAGAAGGGGGCGGACTTTTGGATGGGGTACAAAAACCATCAATATGCAAAAACTGGGCTAAAAGCAATATTTTCAAATTATGCCCGACAAAGGTTCAAAAGTCAATATATAGAAATGAGAACATGAGTATTATGCCACGTGGCGGGAAAAATACGTGGAGTGTAATACGATGATCAGATCCTTGTGAATACAAAGTTTGTGACGACGTGGCCGAGAAGAACTTTGTAAGCCAATGCGTAAAAAGGGGTTCAGTCTAGGCCGAAATTTTTTTTGGGCCACATATTAAGTTAAATTAATTAAAAAAAATCACAGCGTATCCAATTTGCCGAGTTTTGACTTGAGCTCGGCGCGATACGTGTCGATTGACTCAAAATATTGTTTTTTTTTATTTCCGAATAAAAAATGGTGAGTACCTCCAAAATTAGCTTTTCATTGTCCATATAGAACTTTTTGATTTGTTCCACAGTTTTTGTGGCCATCCGGCGATCCAAACTCGAAATTGTCATTTCCTGGTACCAGTGGAAACCTGAAGGAATTTCGGATGTTTTTGCTTAATCATAATCATGATAATCTTACGTGAAACATAAGACTTGGAAAACGAGATTTTTCGAGAGTTCGAATTCAATTTATCTTCAGATTTTATTGCAACAAATCAATTTTCAACATAAAATAATTTTTCCAACTTTTTTTCCCAATTTATGAGAGTTTAAACATTGTTTTAAAGCAAACCGCCAACATTACATAAAAAATTAAAATATTGTTGAAGGAAAAAAATGATGAAATAGATTTTCTGACAAAAAATTTAATTTTTTTGGATTCGCGCTTCAATTATTGCGTTCTTTAAGAAGAGTGATCGAATTTTATATTTCCAATTGTAAAAAAATTTAAAATGGAATGAAACCTTTCCAAAGAAAAACTGAATATCACCAGAACTTGTGATTTTTCAGCATTTATTTTTAGGTTTGAATTTTTTTTTCATGATTGCCAAACGTGAAAAGTGCAATTTTACCGAACATTTAAAAAATCAAGATTTTTCAATTCTCTCTGAATTCCTGCAGATTTTTCGATGAAAAATTGAATTTTCCTTGGGTAATATTATTTTTCGGGAATTTATCAGTTTTTAAAAAAAATTTTATTGTCTCTGAAGTTCTCGATAAAAAATTATTTTCTGCAAAAAATCTACTTTTTCTCATTGAATATTCCGTAAAAAAAATCAGAATTACAAGGCACATTTCCTTTTCTAATCTACCGTATAATAATTCAATATTCTTTTAAAAATTCGGGGTAGATAATGAATTGTACCAATTTTTATTAAAGTTAATTTTTCTAATTTACGTTTCAAAATTTTCTTGAATAGTTTTTGGAATTACAGATTGTTTCAAAAAAATTTATTTTGTTTTTTTTTCTCGAAAATTTGAAATCCATACATTCTAATAGCATTCTTTCTGTTCCTCAGGACTCCAAACATAATTTATCCTGACCTTTCCAGATCGATTGCCATTTGTTGCAATAGTATCTAGTTCAGAAATCTCTCGAACCATCTTCCCTTCAACGCCATAATATGTTTCGCTTCCAATTTGCATTTTCTCCTTTTGGTACACGGCTGTATGTCATTGGTGCACGGAACATTGGTTGACGGGCTTCTTCATTCAGAATTCTGGAAAAGTTGATGTTGTGCGATTTTTTTTGGGTAAAAAAAACAATTTTCGTAAGTTTAATTAACTAATATTTTAAAAAATCTGTCTCAGTTTCTGAGGCACCACGGGTTCAAGATCTGGTGGGATTGCCTCCCGGATCTGGCACCGTGCCAACGCATTGAATGCAATTTTTCTGAAAAAAGGGCAACGAAGATCCGATTTAAAAAAATTTTTCAATTATTTTCCAAAGTTTTCACGAACTATAAGAACGGAGCAATTTTTCACAAAAATTCCAGTTCCTTTTTATGTTAGAATTTAAAAAAAAAATTGAATTTTTCCTAAAAAATTAGTACATTTTCCGATATCTCAAGTGTGCCATAAGAGCCTAAAATCAGAAAACTTTTAAAGGAAAAATTTTGAGCATTCTTATCAAAAAATCAACTTCTTCTCACAATGTTACCTTATTTTCTTTCTAAATTCTGAAAAGCATATCTCAGCTTTTGCTAAACTATTTTTTACCTCAAATTTTGAGAAAATTAAAATATAAGAGCTATGATATAGTAAATATTTTATTTTCTAATAATTTTTGGTATTTCTATTCTTTCGTTTTTTCATTTTTCAAAAATTCCACATAGTTTTAAATGTTCATATTATTTCTTTTGTCCAGGAAAACTCGTAAATTTTAGTACAACTTTAAACCGGAAGATTGATCTTTTAAATTTTTTTTTCAAAAAATTTGAATCTTCGACATGAAAGATGTAGAAGTGTGATTTAAAAATAAAAGTGCAGGTATTTTCAGTTTACAGCAAAAGTCAGTTTAAAAAATTTCGACTGGTTTTCAAAATGAGTTTCCTTTTTTGTACACGTAGAACTTTTTTTATTTTCCGATTTCTGGCGTTTAGTTGCAGAAATTTTTTTTCCGCAAAGTCAGGAAAAATTCAGAAAAATAGGACAGTCAAAAAATTGTAGCTACAATTTTTTGAGTGTCTTTTTCTGAATTTTTCCTACGATTTTGCGGAAAAAAAAACTTATTTTTTCATGAAATCGAGTACCCATCCAATTCCACAAACTTACTCGTTCTCCTCCATACATTTCGTTTGTTCTCCAAACAAGTGGAAAACACATATGATGTTTTCTCATATTATCATTCCAGTACAGCCGGTGTATCGACCGAAGCTCCGTGCCACAGATTCTGCACGTATTCCATCGATTGGATCAGCTTCAATCGCTTTCTCCACAATGGCCTGAGGTTGAGAAGGGAGTCGTCTGGAGAAAAATAGAATAGAATCATGATTTTTAGGTTATTTTACGTTTAAAAATCTAATTTTTAAGACGCGTAAACGTTGGGCTCATTTATAAAAAATCGGCACACCGGCAACTTTGCCGAAATTTCGGAAAATTGTCGGTTTGCACATTTTTGCGGATCGTGAAAGTTCAGAACTTCGATTTCAATCCGCAAAATTGTATACATCCTATCAAAACATCAATCTTGAAAGGCCATTAAATACTCTCTATGGTCTAAAGAAAAGAAAACGATGGTGTAAAAAGATGCAGTTTTAAATGTTGTCTTATTAATAACAAAATTCGACAATTTGCCGGAATTGCAATTTTTTTTTCTCCAACTTCCGAAAAAAACCCACCGACCACCATAATATCATCGTCTTCTTCTGTTTCTTTTCCAATTCCAAGCCCTTTGATCGCTTTTCCGGTGGCTGGCTGCATGAGCTCAAGGTATCCGTATACATAGATTTTCATGTCTGAAAGAAAATTCAAATTTCTTCTGGAATGTTACTCGAAAGTATCATTCCGGACATTACTCGTTGCCGTCGTTTGGTCAGTGCACGGAGGCTTGCCGGACGTGGAACACGCATCAAACGTAAATAAAGGATACACGGTTCACATCCGTGACGCGACATTACACATTTAGCTTAAAATTGTGAAATTAATTTTTTTTAATAGCATCTTTTTTTTTAAATTTCGCCCATGCTTTTTCCATTTTTTCAACGAGTTTCCTTATTTTTTGTCCATTTACTGTAAGTTTTTGAGAATTGTTTTTTGTTAATTTAACATTAGCAAACATTTATTAGCAAAAATTTTATTAGCAAAAAAACTTTTTTAATTTTTTTAAATTAGCTCAAAATTCTCGAAATTTTAGATTTTTAAAGGGTAAACAATATAAAACTTAGGGAGTTTTGAGCTATAAAACGATAAATTGATTTGAAAAAGGATGATAAACTTAGTTTAAAAAACCGACAAAAATAGACTAAAATGAAGGGAACACGGCAGCAGCTTAGCCCCATGCTTAGCCAGCAGCCCTGTAGCAACCCAGTATCAATAATATCCCGTGCCAATTTTCTAGAACTGAATATAAATTGGGTTGCAATGTTGCTAAAGGGCTGCGAAAGACTGAACTGGGATGAACCTGGGCTGCAAGGGGCTGCGAAGTGCTGCGAGGGCAAAGCTCAGGCTACAGTGCTAAAAGGGGGCTGAGCCCAGACACTCAGGAAAAAACTCCATACTCGCAGCCGCACCACATTTGCGCTCTGATCGCGTGCTATCCGCGCGCACAGAAATTCGAAAGTATTACTGTTCCAAATTCGGAATGCGCGCACGAGGGAGAAGACGCAATTAGAGCGCGGATCTGCACGTAAGGAAGAAGTGGGACTGGAGCACGAACCAGTAATCTAGTCGCGCCTCCGCTCTCCAGGAGGTCTAGAGCGATTTGCCGAGCAGGTCAGCCCTTCGCAGCCCTTCAGGAAGTACAATCAAAATTATACAGAAATTTTATATTGGAACGGGATATCATTGATACGCCTAAACAGCCCTATTAAATAGTGATGACGGCGTAAATGAAATTCGCCATTTCCAGCTAACATATAAATTTTTTTTTTTTAACATTGATATGAATGGATTCAGCAGAAAATTTGCCGAAGTCATTGGAAAATATTAAGATTTCCAGATTTCGGTACTCCACTTTTAAAACTGAATTTTAAAACTGTAGTCTTTATTCAATGTTTCTTTCAAAATTTAAAAAGTAGAATATGTGAGAAAAATTTCCAAAATTGTCAAAATCTCTAATAGCTGAAATATTTCACGGCCAACCGGCGGGGGGTACATGAGAATTCTCTACCGTATGATTCCAATTTGGCTGACTGCGTGCTCAACGTTGACTAATACTGAGTGTAAACTTTTCGTACACCGTTGCGTACTGCACAGCGCGCATTTTAATTGACGACATTTAGCAAAAATTATAAGATTTTTCGGAATTATGAAGCGCAATTTTCACAAAAATAATGAGTTATTTGTAGAATTTATGAAAAATCGTGAAGATTTTTTTCTTGATATTCAAGAACAAGCAATTTTTTTCTTAACAGAGGAATCCTCTCGCATGCACCTGTTGTTTTTTGCTCCACTTTAGGACGATAAAAATGCGAATTGTTGATAAAATGAATGATAAATAATATAGAGTAAAAGTGCAAATATGACTTCAGCAAGTTTTAAACCCAAATTTTTCCTGGTCGATTTTCTGTTAGATTCCTGGTTTTGAGTAAACAGTCTGATATATTCCTGATTATAATGATAACAATCACGAACATAAGAATTGTAGAGCACAGAGAAACAACAAATTGCAAACACAGCAACTGATATCAGAATTAACGACGGAAGTACCACGGAAACCTCCTCGGTCTCCACCTCGCCCACCACGGAAGCCACCACCTCTGTCGCGTCCTCTGAATCCTCCTCGATCTCCACCGAATCCACCTCTCCTCCATCGCGGTCTTCTGATATACCACGGAAGCCTCCACCTCCACCAGGATCTGTTGAGAGTCCTCTGAAGCCTCCTCGATCGCCACCTAAAACCACGGAAGCCACCACGATCCGCGGATTTTCCTCTATAGCCTTCGAGGCTTCAGTTGTACCCCATTCTTGGCACGCCTCAGATCTCTACAAAAAAAACAAATTAGAAGCATTTCAGACCATGCTTATCGAAATGTGTACCTATCCCGCTTTATCGCAATCTGTCTATACGTCTTATCCTTTTGGTTCTCAACTTCTTTAACTTGTCCAGTAGCGAGCTTGCTAACGAGCAGCATTTTCCCGAATCGCCTTCACCTCAGCCTCCACAGCATCCAGTGGCTCCTTGACAATCGTAACTTCGAGTAATACGTTGCTCACTCTCCTGCTCACGACGCTATTTCATCTGCTTCTTTTTATTGTCACCGCATTATGGTTGTGATAGAGATTAACCTCTCCGTCTCATCGATTTGTCCACTTCTTCATTTTTGACTCCGAGTTCCAGCGTCAGTCGGGTCCGATCTCACGAAGACGGACCGTAGCTATTCTGGCGAATTCCGCAGTCACGTCCTTCAAAAATGTCTTGTGGATGTTCTTCTTGCTGAGGGGGCTGCTGAAACCAATGTCGGCATGATGAGAGTTCCGGTATTCTGAATCCTTTTCCTGCGTGGGCTAGCGACGAGCTGCACGTCTGAAAATCAACGTTTTTGGAATTTTTGGGCGCATGATCTGGAGCTACAGAATCATTCGATTCTTAGAATCAGCATGCTTTTATTCATATTTTAGGATCTTTTTAAAAAATCTGGACCAAAAGTTTTCGAAAAAATTTTAATTTTTGTGACTATCAGAAATTTGAATATTCACTAAATCGAAAAAAATCATTGCAAAATCCATTCGTCAGCTGAGAACATTCAAAACTTATCAATTTGAAATCAGCATATTTCAGTGTATAATTAAAAAAGTTTCAAAAATTCTGAGACTTTTATTTTTGAGAAAAATAATTATTCGCTCGAATTATTGAATTTTCACTAAGCAACAGTAAACTTGCGCCCATGCTACAAGCCTGAATCTTTCAAATTAAGAACCAGCATGATTTTTTCAATATTCTAGGACGTTTAAAAAAAATCTGGACGAAGTTTTTGAGGAACGTAATTTATACAAAAATGTTCTGATTTTTCACTAAACTCAATTTATAAAAATAGTCAACGTTGCCCATGCTGTACACCTAAATCATTATGCGGAAATTCAGAACCGCCATGTATTTTTTCTTACCAAAGGCTCTTTAAAAAAAATGTGGACCAAGAGTTTTGATATTTAGAAAAATAACTCACTTTTCGACGTTTTTCGCCTTCTCGTTGCTAACCCGACAGTTGATTTTTGCGGCGATTTGTGGCGCTGAAAATTTTTAGTTTTATTAACGAAGAAAACAAGAAAAAACGACGAGAAAACATCAGAAAAATGCGAAAAAACATCGAAAAACCACCGCAACCTCGTGCTAATAACAAAAAAAAAGCATTGCAGCCGCGGGACTAGTTTTCGCAACTGTCTAGGCCATGTCCCGTTCGCCGTGCCGTGTATTTGTTTAATTCCCTTTTTGGAAAAAGTCAACATATTTCTCTAACAAATCGTTTTTCTATTAATTTTTGTCTAAAATTCACAATCAACAGATCTTTTGCATTGCAATTCTCACAATATCCCGACAGGAAACCTCAGTTACAAATCTGATTCACCTCTTTGAATAGTTCATTATTAGTGACGGTTTCATTCAAAGCACATTAATCATTGTTTTAAACTTTTGCACTTCGTGTTTTATGTAATAGAATTGTAATGGACAAAAGAAAGCAAGAGCGTTGGGGCATCTGCAAAAAATCATGAAATTTATTCTCTTTTTATGATTAAATTAGAATTTTCTAAAATTCCCTTTTTTTGACATATGCACTTACAGCCGCATGAATCTTGTTGAACCGTTTTCCGAAATGAAAGAAAGTGGACAAAAGACCAATGTTGATTCTTCTCCAATCATCATGAATTTCTTTTCTTCTCATCGCTTGAACCATCGCAGCGTCGAAATTACTTGACTGTCTCGTTGTTCAGAATGAACAGACCTGTAAAATCAGTTACTTTTTTTTAGCAATTTAAACAAAGTACTATTTCCAAAAAATAGGGAAAAAAAGGTTTGATTTTATAAACTCTCGAATTTTTATTATGGTCAATTGTTATTTTTTCCAGAGAAAAACTCATTCTCCCAATATTCAGAAGTTTCTCTCTAAATTTTTTTCCCATCGTACCCTTATCTATAGGTAATTGATATGACGTACGATCCAGTCTGAGATGTCTTCTGTAAGCCGTTTCTCGTTCATTTCGTCTGGAACCGCCCAATCAAGTTGATCTCTGTACGGTTCTTTTTCCAATTGCTTGCAGTTGGCTGTATAATCGCCTGATAGCGTGTTCGGTTCCCACGTGGATTAGATTGTCGACATTGAAAGTGGATTTGCTGGAGGAAATTGGGAATTTTTCAAGGTTTTAAGTGGATTTTCAAGCTATTTATAAAAGCAGGAAAAAGCTCAGAAATAAACTTTTTTTACGTCGTGTTTTTTCCAATGGAATTACCTACTTTTAACTAATTGTTCGGTTTAAACCCAGAAACTTGTTTCATATGGATTTTCCCGGTGAAAATAGAAGGAATCGTCGCATTCTCAAAGTTTTTTCACCGATTTGTTTCAATTTTAGCACAACTCAATGAATCACAAAAATTCCATTAGAGCCGATTTTCGTAAATTGGTTCCTACATTTCGAACGAAAAATTGTCCTTTCTGTTTAAACCGGAAATTCTCTTTTGAAAAACCAATGAAAATTTGAATTTTCTGCGCTTTTCTTCGGAAAATTATTCTCGAAGTTTATCAATCGATCCTTGGTCTTTTTTTGTTCCGCAGATAACGGCTGGCGGAGTTTACAAGCGTACCAAGTGGTTCAACTTTTATGCGATAAAGCTTTATAAATGGGACATAGATGAATAATATTTCGAGAGGCTAAATGCAAAAAGAATGAGTAAAAAAGCGCGCAGCCCCGTCCATCTCTGACGAAAAACGCCGTTTAAGGATCGGCTGGATTGCAATTTCCGAATGGGAGTAGTTCGAAGTGTCAAAATGCCGGAGAGGTAGTCGTCAAATTTCACCGAAACGTAACCCGGTAATTTCCACAATTAATGGTCGATTTTTCGCAACAAGTGGTATGTTTGTCAGGATTTATATTGTGGCAGTCCAGATTTTAAGGATTATTTTTGGGCAAAAATGTCGAAGTAATTTTCTCTGAAAAAGTTCGTTTATTATAATTCAGATTTTTTAGATAGTTTTCATCAATTTTGCCAGTTTTCAGCCTGAGAACCTTACTAAAGTACGATGTGTATCATGAGCGCCCCTTTCATGAAGCTAACGAGCTTCAGCTTCATCTTCGTCCTCTTCATCCTCCAAATCTTCATCCTCATCGCCCATTGATTCCCCAGACGTTGTTTCGCGTTTGCTCATGGATCTTATAGGACGAGCCTGAAGATTCAATTCTTTTAAATTCAAATTTACCGCTTAAAAATCGATAATTCTCCCGTACTCTGGTTTCTTCTTCTTGTTCCGCCTGCTCCTCTGGATCATCTTCCTCCATTGACTAGGGCCGGCATTCAACATATTCAAGCCTTCGTCTGAATTTCTGGCCAATTTATACAAAAACCGACAAAATAATAAGCATCACTTTCTTTTCGCGTCTTCGTCAGAGACGTGTGAATCCATTTCCTGGAATTTGAGTTTGAATGTTTTTAAACAAATTTTATGGAGAAAACATTCGAAACACTAGAACTTCTGTTGAAACACGAGAAAATTTTTTGAAAATCCATGAGAAAAACAGTTTTGAAAAATCTGTTTTTGGAGGCTCTCCGTTGAGGAATCGTCACCCGAGACGCAGATTCTCCGGTTTTTTCATAGTTTGAGTTTAAGAACAAAACAGTTTAAAAAAATGTTTTTAGTATTTGAATGTAACTTATAATGTATGTTTTACTTCCATTAAAAATTAAAAAAAACTACAACCCTAAATTATCATGTAAATTTGAAACCGTGAATCAATCTCCGCGGAAGGGCGAGCCTATATTCCGCAAGCGCACTCTATCGCTAATGTACAATGGGCGGTTTTTCTAACTGCTAGGAATTAATCGGATTCTCGAAGTTGATTTTGGGTTTCTTTTTTTCGGGAACATATTGGTGTTTTTGCGTTCAATATTCAAACTTAGAGGAAAACTGCTTCAAATAATTAGGGAAACTCTTGAAACGAAAGCGCTGAAAACAGGCAAAAATAATTATTTTTGTATTTTTTAGGCTACTTTCTATACTTTTGCGTACATACTATAGTTATTCTATAACAGCCATTAAAATTATTAAAATGATTTTTCCATTAAAAATAAAATGAGCAAAATGATTCTTTTCCAGAATCCTATATGCGCCTTTAAAATCTCTCGGATTACTGTTTCAAAGAAATTCTCCTTTATATTTTTAATTTTAAATTTTTTCCTGAATGTCAAATATTAGGGTAAAAATCATAATAATATGTGCTATTCATATGAGTGTGGGCAAGAATTAGTGAAAAAGAACAAAAACACGTATGGACTGTAAAATTGGAATTTTGAAAATAAAAATAATATGCAGAAACAATTAAAATTTCCAGGAAAAAAGTCAGTAAAACCATCAAGAAAAAACTACTCGATTTTGAAGGAAATCAGCAAGAAATATCGTAGAAAAAAGTATGTTTAATTTGGAAAACCCCTGCTTGAATTTGTTTACAGTAAATTGGGCATAAAAGCGTATTGGCAAATTCGCAAAAACAAAAATCTGGGGATCGTGATGTGATGGAGTTGGGTTTTGTGAAAAAATTCAGCGCGGAAAAAATTGAGTAGACTATTTCAAAAATGTCGATTTTTGAAATTTGTGAAAAATTGAACAAAAACTGTTTTTTTTTGGAATTTCAAGAAGTTTTATAAATTTTTTTGGTTAAGATCAATTTTGAATATTATCTAGTTTGGTTTCACTTAACCATGCAGAACAATTCGTACAAAGGTATTCTAGAAAGGAAATGTGCGCTCCAGCACATTATTTGCTCGTGGAGCGCACTTGTGTGCACGTACGCTAGACCAGAATGTGTGGTAGAAAGGGAGGGAATAGGAAAAACAACAAATTGGGCAATGTAAGATTCGGAGAAAGAATTGGAACGAAACAATATGTATTTCGAGCTCCGCGAGCTGGTGGATCAATCCACAGGCTCTCCATCCTTGCGTTTTCGAGAGGCACATTGCATTCTAGTTACACACACCCGAGCACGTGTATAATGGAACATTGAAGCCTGGAAACGAGCCATCGCTACCATCATTACCACGTGGATGAAAAACTTAAATTTTGATGATTCGAAAATTTTCTGGAAAAGTTATGATTGTGAGATAAATTGAATTCTTTGAAAAATCAAAATTGCAAATGCTTGTAGAAAATTTTATATATTTTTTTAAGCGTATCTTTTCTGTATACATTTCCAAATTTTTTTGTTACCCAATTTTAAAGATTTTATTGAATTTTAAAATTCCTTTCAGTAATTCGGAAACTTTTTTTCAACTTTTTGATTTTCCGCATTTTTTAAAATTTTATTCAAGGAGAATTATTAGATTCTTTTGAATTTAACGAATTCTGTTCGCTAAAAAATTTTTCGATTTTTCCTGATTTAACGTCTGACAAATATATCTGGTTTTTTTATTTTCCTGATTTTTCTGTTCGATTAAAAATTTATAAAAACAAGTTTTTTTCTAATTTTTGGTTTTGATGATTGTGTATTTTTTCTGAACTTTACAGTTTACGATGACACCGATCTTCCACATTAAAAAATTCGATACAAAAAAGCATTAACATGATTTTTAAAATTTGAATTATTTTTCAAAAAAAATAATATTTCAACTGTGTTTTCGGAATTTTCGATTTTTTCTGAGTTTTTTTTGGAATTTTTCCTCCTTTCTGCTACCAGAAAAATATTGCCAAATTCAATGTTGTGTAGTAATTGTATTCAAAAAAAGTGTTCAACTTCTGAGTCTAAACCTTTTCCGAATCCTTAAATCCTTGCAGAGCTCTCGTGAATTCAGTTGTCAATTATGTGAATAGCAAGCTGCGTAACATTTTAATGAAAGTTTTAGTTTGTCAAGGACTCGATTAATTTCCGAATAATCATAATCATCGACTCGAAGATCATATAATCCTTGAGTATAGTTCCAAATTACTTTGCTTCACGGAAAGCAGCAGTGTCAATTTCATTTTGATTCACGGCGGCTGGTGGTTCTCCTTCTCCAGATGCATGGGATGAGCCGGATGGCCTGAAAAATTAATTTTTTGGAATTATTATATTTTTCGGTTTATTTCATGCATCTCGATTATTTTAACAAAATTACCAAATTCAACTAGATTACAACTTGCACTGTGTCGATTTACGGGTTTTGGCGTTATACGAGTTGAATTTGTTTATCGATAGAATATTAAAATTTAGCTAAAATTGAGTAGACTATAAGAAGAATTTTTTTAACTTCAAAAATCATTCGAGGCAAAAACGTCACGAGCGTCAGGATCGACACAGTAGTCATTTATATAAAAACCAGTTTCGGCCACGAAATATCTCGCGCCATTCTTCAAACATCTTGGGTAGTACGTATTCTCAAAACTGTGAGTTCACGTATAATATTCATGCGAAATTTTGGTCTACTTTGTTAGAGAAATCATCACTAACATATTGCCAGTAGGCCGAATATGATATCGAACATTCGATCACGCCGTGACGTCATCTAAGTGTATCCGTATATTCATTCGTTATTATAAACATGATCCCATCCAACTTCTTCAACTCGGAAGGGCGGAATATCCTTTTCAGGTCTTCATTCTAAATTCAATATATCCAAAGTTGAATGGTGCGAGTAAATTGGATAATTTTACACGGCGCTTTTTCGCATAATATCTTCTCCATTTTTATCGATATTTGCATACATCATGATACAGGCGAGTAGTTTTTCCGTTTGGAACTATCTGTTGCTGCAGGAGCACTAATCATAAATGATTCAATAGTTTCAGTAGTCATTGCACACATCTTCGCTGGTGGCCTTGTCCTTTTTCCGACGTCTTTTCCAGCTCACTGATCAAATACTTCAGTTGGCCGACGATCTGGCATTCCTCATTTCGTTCATGATATAGGCCGACTGGCCTCCCAAGAGTCGGGTCGACATTATCGATATTAAGGAAATCAATCTGATCTTGTGTCAAATAACACGACGTTCGAATCCAATACAGCATATAACTGTGCACATTGCGTGAGTCGTTGAGATCTATTCCGACGGCGAGGTAGAGAGCAAACCGAGCAAGTTGTAACGATCGCCCAGGACGTCTGGCGTGCGGCGAGCGAAGAGCACCTGGAAATTTTCCTTGAGAAAAACCTATCATCGTTGTTATACGTTCCTTCACTTGGCATTGGAGTTGGCAGCATATGTTTTGAAAAAACGTTGTTTTTGTTGAAAGAACATTTTATATACGGGACCATGAGATAATATTCCTATTTCCTTACTGGCGCGAAACCAAAATATGCAGGCCACGGCAACGAGAGCGCATATGGCAAAGAGAGACGAATCTTATTTTCTTGTAATTTTTACGGTTTTAAAATAATTTAGAATCCTTTTCAACTATCTTGATTGTAAAATATTACAAATTACAGAATTTCGCTACCAAATTTACTGGAAATCTAAACTCTGAGAATGCGCATGGAGCAACATATTTGACGCGCAAAGCTCGTAGCGAAAACTACAGTTATTCTTTAAATGACCACTGTAGCGCTTGTGTCGATTTACGGGTTCGGTTTTTTAAAGAATTTTCGTGTTGTTCGAGAAGTGACAGTGGTATTCCTTTTCCTTCTTTCTTAATCCTATTATTTTATCATTATATGCTTAATTTTAATATTCAATTCATACAACTAAATTATTAATATTTCGAGTAGACATTCTAAGAATTCCGGTAGTATTCGCTTCGAGATATTTTTCGCGTGAAATATTGTTGTGAAATACGCATTCTTAGAATAGATGGTGCTCCCGTAATAATCAGATAAGAAAAGATTTAGTCCAAGAACTTTCCGAAGATTTCAATATTTGCAAAATCAGAAACCTGACCCCCGAAGATTCTTTAAATTTTAGAAATTTTTCAAGGTTTGCTAAATAACTCTAACTTATTTCTTCTATTAATAGGCCTGCAATACTTTTTCGATGGTCTTGCCGCTTCGGGCAATAACTATTAGGGAGTGCAAGTCTAATAGAGAGTGCCATACTATTCTTCAGAAAGTTTTTCCGTGTTGGGGCTAGATTCTATTTGAAAAAACTCCAATTTTATTTGGAAGTATAGAAAATTTGATTGAAATTGCAACAAAAAGCACAATAACGACTTCCAGCTCGAAAAATTTTGTTATAAACTGTTGCATAACAGGGAAAAAATGTTATTAAAAATGTTTTATTAGTAAGAAGTGTTACAAAAAAAAGTAGGTGCAAGACTATTAGGGAGTGCAACACTAATAGGTGCACTACTAATTTTCGGAAGGTCTCCGGGCAATACTAATACAGGGAGTGCAAATCTAATAGGGAGGCCATATTAATAGAAGATATACGGTATATATAGCTTTGAAAAATCGGAAAATGCCTAATTTTGCTACTTTTTGAGGTTTGAAAATCTCTAAAAATTCAATAAATAAAATTTGGGTCAAATTACCGCTAGATTATTCCCATGAATCATCCATGGTCTATGACAATTCGAATCAAATAAACCAATTTTCGAAATTTCATGTATGACCAATCATTGCCCAACAACCACATTTCTTGTCCACCCCAAGCTTTGCCAGAAATTTGCGACGATGATGATCCATAAGTGATAGGCATCTCTGACGTGATGCAGCCATTAGTGCAATTGGTAAGACGAGCCGAAGCTGGTAGATCACTTATATCAACGAACATATGGCCATAACTTCCTGTCAAATTATGAACATGTAGAGTTGGGAGTTTACATGTCCAGCTGGAATAATATGGAAACGTGAGGGAACAATTAGTTCGAGACGGGGAGGGGCAGGTTGGCTTAGGGTGCCAACCGACATAGCCGAACATTGGGGTTTCTGATCAGCTTAGCGCCAGCCGACCGTCTACTAGTACTGCAGCTAAATTTTCGTCGGCTGTCGGCTGGTGAAAATTTTCATAATCAATTTTAATGGATGTTCCAAATTTTTCCCTAACTTGACCAAATTTGTTTGCTGGCCCAGCGACACCCGATAATTTAGATCATTGCGCATTACGGCAGAGGCTACTTGGCAGAAACTTTATAATTTTAAATTCAGAAATTCAATTCGTTTTCAAATAATATTTTTTATAACTTTACCGATCAATCACTTCAATCGGATCAAATTTGAGCCAATACATCGCTTGCACTTTTTAGTTGTAGTGTGCATGTGTAGATCTTTTTATCTGCGAAGTGAGTCAATGAAGAATATTCGCGACCAGTTTCTAAAACTCAGTTTTCTAAGGAAATTTCTGAAAAGAAATTCGAGAAAAAACTGAGTCAGCAAAAGAAAATGGGAAATGTATGTCTGGAAATGTATTCGAATATTATATTCAAAACAGTTTTCAAAAAAACAACGATAGCAATGGTGATCAGAAAGGAAGGAACTGGGCGAAAAAAATTATCTTTGAATCTCTTTGCATCTTTGTGATCTAAAAGATAAAGGTTTCACATTGGAGATTTGTGAATGTGATAAGGGTGAAAAATGGAGATTAATTGTGGTAAGTAAATTCAGGAAAAACCTAATTTTTGGTGAGAAAATTGTGGAAAAACTATAAAAGAATCTTTGGGGTTTAAAACTCAAGTTTTTCGCTGTTTCCGCACTGTGCTGACCAGTTTTTTGAGAGTTTGGCCGAATTCGGTGATTAGATCAAAAAAATAATTTCAAAACTTTGCGCCTCAAGTGTGACGTATTCGTACTCTATTGCCGTTCCACCAAAATTTCCTTCATTGTTTTGTCATTTTTCTGCATAATAACTGATCTGGGTTTTTTTGCTGCATCACCCAAGTGTACGAATTTCCCTAAAAATTATACCGGTATTTTTTCAAAATTTTTAGTCGCTAGAATCTTTTTTATTTTCTTTAAAAAAAGAGTTTTCTCGCGAGTAGAAGGAGAAAAAATGTGTGGCCATACTTCTTCGTTAAAGAATGCACGACTAGCTATAGCTCAAGCCCCCTCTGGAACGTTCCATCTTCCTCCCATTTTCCCACGTTCGAGAATCACTTCTTTCCCTCAGCTTCTCTTCTTCTAAAACCACAACTAGACAAATGTGCTTGTTTTCCATTTTTCACATCGCCGAGAAACCCGCTATCACAGACTCAATGCGCCTTCACCGGAGACGGGGCTATTTGTGTGTGTACATTGTACTGATCTCTGCGTGATATACGAACACCGGCCTCGGATTGAACCAGAGGGGGGGGGGGAGGGGGGGGGGTGTGGTAAAAAAAGAGAAATACTCTGAAATTCAATCTAGAAGTAGAAAGAAAACAAAGCGAAAAATTGGACATTCGTCCGGCTAAAAAATCTCATGGAAAACAAAATCTACTCCGTTCGATTTGTGAGCATTTTCATCCTATCTCTCTCACAAACCCGACTAAGGAAACGATAAAGCCTGGGCCCATCCCCAAAGTGTGCTCTCATGCTCTGGAGCGTTCTAGACTGTCTGTAGAGCCACAACTGGCGGAATAGCACTGAAGTGATGGAGAGCCGTAGAGAGAAGAAAAAAACGATTTGGTGGCGGAGGAGATGGCTTCGGCCCTCCAAATAAACAACAATTACTCGATATCGTTTCCTCTGTGATGGTGTTCTCTTCAATGTTTACTGTACGATATTGAACAGGAAATTAAATTGAGGTACACTCTGAATACATATACACAATAAATAAATACAAAAACTATAGTTTCCGCACAAAAAATTCAAAAAAAAAACGATTTTTTTTGTCCGAGAGGAGTATATGGCCTAGAAAAATAAAACTCGCCGATGCCTCTTTGGTCTGATGAAACTTTAAAAAATTATGGCCGAATTTTAGATTTCTCAGGCCAATATTGATACGTTTGTCGATAAGTACCATAAATTAGTCGGTTTTTCACGGGATTCTTCATTCCTCATGCTCATATTTTTCCTCCATTGGCAATCTCCTGCTGGACAACGCGTGGGAAATCGTGTGCCCTACACGGGCAAATACATTTTGTTTTACAAAGCAAACCGTGCCGCGACGCGACACGCAACGAGCCGTAAATCTACCCCAGATATGGCCGAGCTATGCCCTAACCTGTCAAAATCTTCCACTTCAAAAGATGAGGGAAGCCATAGAAGCTCCGCGTGTTGTTTCTGAAAAAAAAACCCGCCTAAAGTTGATTTAAATTATCGTTTCTTTGGAAATAATAAAATCGATGAATTTGTCGATATTGATAAATTTCCGATAAAAAAAAAATTACTTAAAAGAGGAAAAAAAATTCTCTTTTAGTACCAACAAATACGCCCATTGGACTAACCAAATCGTTCTTTCAATCTTTGTTTAAATCTTTGTGCGTCTATAATTGTCGCTTCGGAAAACTACACAAAATCACACACACACACAAGGAGAAGAAAAGAAAAAACGTGTTCCATGACCTGCCATCTGGGCTGATCGATCTGTGAATTGGGGAAAATTGAGGTATACTGGTTTTTTATCGGGAAGATTTTTTCGGAAGGATTGAGATGAAAGTTCGAAAGGTAATTCGCAAAGTTGAGATTTGAAAAATTCGAAAAAAAGACAATCTCAATTCTGCTGTAACCCCCAATTTTGCGTCATGGCCCAGAGTATGCAGCGTGCCCTAGAAATTACTAACGTGGCCTACAAAGATCACGGCGGTATCTATGATTTTCTATGTGCGTGACCTAGAATATACAAGACCTAGATTGATTGCGTAGAACATCTCCCAGTATATCCTAGCAGTCTTAAGTGGCAGTTTCTCAGTTAGTACGCCCAAGAATTCTCACGTCAGCATGACCTAGGATGTTAAAGCGTGGCCTACGAATTTTCAGTGTCTTCTAGGATATTCCAGTCTAAAAATTGGTTCAGTGAGGCCTGAAATCATCGCGTGTCCTAGAATGTTTAATTGCAAAAAAAAGATTTGAAAACTAGTATTTCCCTAGAATTCAGTCTGAGCATTATTTTTAATCTAGTTTTAAGGAAAAAATCAAAATAATAAACATTTTTTGATTAATGTCTCCGATCTACAGATGGGTGCAAGAAAGAATGCAACATTGTGATTGCTCGGTGGAGCATGACGATAAAAGAAAGAGACAGGTCCCTCACCTCCCCAGTGGTCGAAACAATTATAAATTGGACAAACGGAGAAGGGGTCGGGCAGACACAAGAGAGAGAGTACGTGAAGAGGGTGTCCAGGAAAAATGGGATGAGGGCAAATCTAGTTCAAAGATGAGCACTTTTCAGGATCTTTGATTCTGAGAAAATCAGATTTTGAACAAAAAGAATAGTTCATAATTTAATGGCATACATAGAAATATTTTCAGATTGTTCTTCAAAGAAAAATATTTTTATGGGACATCAAAGTTTATTTATTGCATTCTTCCAAAACAGTGGCCGGTCTGGACAGTTCGAATTTTTGTTAAATGCGAGGAGGTGTGCGCCTTTAAAGAGTACTGTAATCATTTCCAACTTTCGTTTTAATATTTACTTGTGGGAAAACATTAATGCTTAACGAAAAATGACAGTACTCTTTAAAAGAGCACATCTTCTCGCTTGTGACAAGCATTTTCGCGTCTCGGTGACAACTTTTAAGTTAAAGGCACAATGATAGAACTTTTCTGAAGAATTTAATTTATTTTTAAGTTAATTGCTACTGGGCTGTATCCTTTTTCAAGTCGCACGAGAGCCAAACTGTAGCAAATCTTAAGAAAAAAAGTCGACAAAACGTGCCGAAATTAGTAAACTTGAGAGCTTTAAAACTCTATTATCAGTTCTTCGCCAACAAAAAGAGTACCGTATCAGAAACGACCTTCGACTTTTTTGGCTCTCCTGCAACTACGGACATGAATTAGTTCTTATTGACAGTTTTCAAGTTTTTTTTTGGGAGTTTTATTTATTGTGCATTTAAAAAATCGTACTTTTAAGTTTGATGCGTGGCCTAGAATTTGCCCGTGTGAGCATCTCTCCACGGTAGCCAAGAAATTTTCTACCGTGGCCTAAAAACTGCCAGTGTAGAAATACTTTATTGTGGCCTAAATTTTCCAATGGTCCTGTTCTTTTTATAGTTCGAATGCACTTGACTTTTCGTTCGACCTGGAAGCGTAAAGAGTGGTGGCCTAGAAAACGATTCATGAGCAGAGTATTGAAAAAAAAACGAAATTTCGAGCAACAAGCGAACAAAAATCGTCTGTCGATAGAGTCTTTCGAATACTGGGGATGCAAATCAGCAATTCATTCTAAAAAAACTTTTGTGATAAGAAATCAAACTGATAAGCCAGTGTAAAGTCACGTAAAGAGGATTGAAAATAGCATTTCAGGTCGGGGTACGGTAGGGTTTTTGTAGAAATCTTAATGCAACATTTCAATGGGCAACGAGTTCGTGGCCTAGAAAAATCATGTCTGAAAAATTTGCAAATGCGCTCCGGTAGCCCGGATTGGTTAAAAATTTTCAATGCCTATTTGAAGTGGCGGCCTAGAATATACCAAATAATGGTCTAGTACTCAAATTGGCGGCATAGAAATCAACCTAATGAGCTAGAGAATCTTGTAGGCAGCTTTGATCACCTATGATAGGCGGAGGTGATAGGTAAAATTGTAGACAAAGGTAAGTTGAACATAGGCGTAGTCGTTTGCAGGCATACATAGGTCATTTATTAGGCAGATGAGGCCTGATTGTACAGTGCCGTCCAAAAATATATCCTATCTTTGACTTTCGATAAATTTACAAATTGCGTTTTCAAACGAGCACAACTTTAATACTAGAAATGTTATCGGAAAAAGTTCAACTCATGTATGTATTGCCCATCATTACGTCTACTCGTATTCAATTGTTTGTTGTTCAGGCTACCTACTGTCACGGTCCGACATCAAATACAGCGGCCGACATCTCGTAAGCCCGTTTTTGACAGCCCACGTTTACTGATTCGGCCGTATCTCGAAAACTTATTTTTTTCTGAAAATGTTAAAGTGAAATAGTTTTCATATTATTTGTTATCATTTGTGTTTATTCACTTTGTTCTGAAAAATCCAGTAAAAGTTATGGGAGTGCAAACTTGTCGCTCACTGCAGCTTAAACAATCAAAAATCAGGTTACTTAACTATAGTTAGTTCTAATTTTTTTTTTGTAGAGCATTTTTTAGAAATAACACATGTAAAATCACATTGAGCGAGCTATATTCAAACACGATGATTCAGGAAAAAATTCATTGGTGGCGAGAAATGTTCACGGCGTAACACTATTCAAGTTTGATCTCTCATAACTCTTTTTCTGGATTTTTCAGAACGAAATGAATAGACATAATGACAAGTAGAAAACTATTTTAACAACACCTCGAAAAAAAAATCGCTCCTCGACATACGGCCGAATCACTGAGTCGTTGTCAAAAACGGGCTCACGAGATGTCGGCCGCTGGATTATTTGTCGTGGCACTGGTAAAAAACTTAAAAAATTGAATACAAGTAGACGGAGTTATGGGCAATACTTCATCTGTTAGCGAACTTTTTTCACAGGATATTTCTAGTTTTAAAGTTGTGCTCGTTTGGAAAAGTTGTAGCAAGTTATCAAAAATCGAAGATGGCATATGTTTTGGCCGGTCCTGTAGGTTAAATAATCTCGTTATCAGGTGTAGCATGAATCAAAGCCATGTAGGCGGGCGTAGGTATCTTCTAGCCGAGTAGGCGTGTTACCTAAGGAGTCAAATGCAGACGTAAGTAATCATAAATAATTCACACTTTGTGCGCAGGCGTAGCTCACCTTGTTAGACAATCATAGTTAGCTTTTAAGTAGGGTTAGGACACCTATTATAGGCAGGTTTAATTCCTCTTATATGTGTGCGTAGAACACGATATAGTCAGGTGTAGGTCACTTTGTAGGCAACACGTCTAGGTTCTTCTTTCGGCAGGCGAAGGTCATCTTCTGAGCAAGGTTTGCCTTGTAGAAGGGTCGATGTACGTTGCCGTAGGCAGACTAAGTTACCTTCTGGGCCTGCCTATAGTGACTAGTAAGGCAGGTGTTCGAACCAAGGGTGTCAGTGACCCGTAAAAATTACAACAACGGGACAACTGGATGTCCCGTTCCCGTCAAAATTTTGAAAACGGGACAACACGTCCCGGTCCCACGAAAACACCCAAAAAACGGGACAACGGGACCCGTTCCCGTGAAAATGCGCTCAAAAACGGGACAAAAACGAGACGTCCCGTTCCCGTAAAAATGACAAAAACGGGACACCGGGACTTCCCCTTCCCGTGAGAATGTATTTTGAAAACAACGGGACGTCCCGTTCCCGTGAAAACACCCAAATACACCCAAAAAAACCGGACAACGGGACAAAGAGACGGGACACGGGAGACACCCTGGTTGGCACCGCACTGAAGAATGCTGAAACCAACTTTTTTTTCAAAAATGGCCCTGCTCAACGAGCCGAATGCATTTTGGTCGTATAATATTGGCATACCTTTTTGCCACCGTGAGAATCATTGAACAAAATCATGCACTTTCAATTTCATTTTTCATTTCATCAAATAAAAAGATTCGGGGATTTGATATATATTGGAAAGTAATAAATGAATGGGAGATTTGTATGGATCGAGGGGGAAAAGTGCACACCCCGGGAAATGATCAATTTGGAGCAGGCAATTGAAGGAGCTGGAGCAGGAGGCTACACTAACCACCCCTTCACAGCTAAACACATGGCTAATAAAATTGAATATTTGAAGTGAACTACTAGTGATAAGCGGTGAAACGGGGTATGTGGCCCTCATTTTTTTTTGACACTTCGAAAACCGCATTTCTTATCACTTGTGTGCAGAAGCATTGAAGCAGGAGGCAAGTGGTGGTCTAAAAATTAGAAAAGCTCGGCCACTGCTTGCCCGATAGGAGCACACGGTCGCATACTGTTTCAACAGAAATTCGAAAAAATTGGAAAATCCCGTTGATTCCGCTGAATCCGACGATTAAAGAAATTTATCCTCGCGTTTCTGATTGCACTGAAATCGCTCAGTATTCTAGAAATTTGTTTTCTGCGAGTGTATATTGTTTTGGAAATGTTGTGTTCATGTTTTACGAAGAACAATATAATATTATGTATATTAGTTATTATATATTATTATAATAGAAATTTTACAACGTAAAAACCCCAAACTTCTAGAAGAAATTGCCTCGCGTGTCTCATTACAATAAAATCAGTTTTTTTCCTTTATTTTATATTACAATATGTATATCGATTCAGCAAAACGGGCGGGACAGAAAATTAAGAAAATGGCGAATAGTTCGTTCCCGCGGAAGTAAATTTCCCCGAATTGGGGAGAAAAAATTCGAATTTTTACTGGATTTGTCTCAAGCTTTTGAATCTAGAAACAGTTTCTCTCTAGTAGAATCTCTTTAAAAAATTTTCGTTGCACCAAAAAGTCACTTTTCCTACTGAATGCGAATTAAAACATTCCGCCAGGAGACCACACAAAATCGAGAGACTTAGTTAGACAAGTAGTGGGAAAATAAGAGGCAACAAATCATCTCCGAAAGTTTTTTTGTGCAGAGTAGGGGAGAAGTTGCGGCGCTGAAAGACAGAGAAAGGGAGAGAGAGACAGAGAGGGTGAGAGATATAACAGAAAACCAGTATGGCGGAGGAAGAGAAGAAAAAAGTGTTAGAAATATTTGTCCGTCGACGCCTTCTTCGTCTTCGTCCTTCATAAATGAAACCATGAATTTTCCTCAGATATTGCCTTACTATTAAATGGGGCCCACGGGGGGCGAAAGGGTGTGGCCGGCCGATCCAAAACGGTGGCCTAGCAAAATATCGGCGGTGGCTCACGGTATCAAACAAAAAAACAAACATCGAATGACCATAATTTTTAAGCTTTTCAGTTTTTGGAGTCATTTCTGATTTTTATCCCAAAAATAGAGCTCTGTGCTATTTTTATGCAGAATCAGCTGGCTAAACTTGGTTTTCGGAATTTGTGCGAGTCTTAGAGATTCCCGACACAGCATCGAGTTTTACTGGAGAACACGTAGCGAGCACAGAAAAGGAAGGAAACAAGAATTGGCTCCGCGAGCAACCAAGCAGCCGTTCAAGAACAAACTGACCGAGCAAAGAACAGCGCGATAGGGCTCATGTATATCTTCTAAAAATAATGGATACTGGATAGAGAGATGAGAGACAGCAGCAGATGGTCAAATGACGACAAGCCACTTTCGAAGATTATTTGGTTTATTCATGCGTGTCTTTTTTTTTCTTGCAAGAAAAAATGATCATTAGCCGAAAATTAAATATTGGTTGTCCGAAGTACAGAAATGAAAATAAATCGTCCGCAAGGAGTACAAAATTCAAAATGGCTATTATCAAAGAGAAGGACACAATTCAAAAGTGTATATTGTCCGAGCAGGAGTACAAGATCCAAAAAATGAATTGTCCGAGAGGAGTAAAAATTCAAACCACAAAAATCCTGAGAATTTCAAGAAAGGGGCGGAGCCTGATTCGAGTGGACTGTCGTTGCAAAACGCAAAACTTCAAAAACATACCGTTTTCAAAATCTACCTCGCCGACCTACCGTAACCCTCTAAAATTTCTCTAGGATCAAATATCATCGCAAGAAGTGTTCGTTCGAAACGAAAAACGTATTTCTGACGCCTCATCACTCATCTTATCAGTAACAAACCTGAGAGAGACGGAAACAAAGTTCCGAACTATATTTTGAACCGAACAGGGATCCTGCAAATCACGTAATGGACAAAATGCATTGCTATGCAGCAAGACGCAATTGCATTCTTCAGCCAGAATATCGATTTTTACTACGTACGTATAGTGATAAAAAAAATAGATGCTGAGTTACGATCTTTAATTCGCCGGATGTGCGAGGTTTGCATTTTTTTTAGCCTTTCGAATTGTCGTGCAGAAAAACCCGTAAGCATGATTTTTCTCAGTAAAAATTTCTTGCGCCAAAATTGTCTTCTATTTTTTTCGCGAAAAATCAAAAATCTCCAAAACTTCGGTGGAGCGCACTTTCTGGACCACAATAAGCGAAACATCTCTTTCTGCGGTTTTCAAAAAATAAACGAACAAACATCAACAAGAAACGAGAGAGAGGTTTTGTTGCCTTAAAAAAATGGATATCGAATTTCTGTGCTCCATTTCCCTCTCCGAGAAATGGCGCGGGGAACGTGCAAACAGTGCGAGTATGTCTAATGGCTCTCACGTAGATCGAGAATCTCGAGTGGAAACTTTGCTAGTATAGACAGTTGAAGGAGGCCGGAGTCTTTTATTCTATTGGGGAACCGAGAAAATTTGTTTATGTCTGGCCGTGGAGCGTAGTTAATGTAATTTTTTTGCATTAAACGTGCTCCATCGAACAAGTAAAAAAATATGCATACTAGTATGTACCTTAAAATAGTTGTAACACGAATTGCCTGTGGAAATAAAAATCACGGCAAGTTCTCTCCATAGGATCAATGTAGGGAATTTTGCTGTTTATAATGCAAACGTCGAAGTCTCTAAAAAGCTACAATTTTCGATCGGTATCGTTCATGCATTTCGACTGATTTTCGTTATTTTTTATTGGAGTACGCTCGTTCTATCGAAACACGGGGCCCGAGAAAATATTATATCCAAAATCTAGAGAGGTTGTCTTGCGCTTAGCCGAAGTGAAGATTAAAATTGTTCAGCCTGCGTTGCCCGACGACTTTTTGTAAAACTTGGCCACCAACTTTTTTACGAGGCTGCGGCTACATCGCATTTGGGTGACTTTATATGTGTTCAGGGTGTCCAAACATGCACCCAAAAGAGAGTGTCATTTTTAACGCACGAAACAGCAATCTCAAACGGGGCGACAAAAAATGAGAGAGAGAGAAAGACGGGCGCAATCTAATGTTTTATCAGTGTTCTCTTCTTCTCCTCCGACCTCGTTTGCATCCCCCTAATTAATCATTCGTTGGTTTGTAATACAGAGAGAGGGAAATAGTGAGTGTGAGGGAAAATTGGAGATTGAGAGAGTTAGAAATAGAGAGTGAGAACTTCAAGTCACTTTTTAGCCGTTTTAAAAAGTTTTGGTCGATGATTTTGACATTTGATAAACCTGAATGAGAGATGATGCTTAGATAAATGAAAATTGAGATGATAATTATACATGACTTCACTTAGAGCGATGTTGTTTCACGTGCAAATTGGTGATTCGTCGAGAAGTTGTGACTGTTCGTGTCGGGAAAATTTCACTAGCTGTGAGCGCCCTTTTTAAAATGTAAAGTAGCATAATTTATTTTCAGAAAATTTAGCGTTGGAAAAATAAGTAGTGCGCAACATATTTGACTCCCAAAACGTTTTGTAGCGAAAACTACAGTAACTCTTTAAACAATACTGGTTTGGTTCTGGTGTCGCGGGCTGCCAAAATTCGAAAGTAAATTCATTAATAATCGAACCAGTAAATCGAGCGCTGCAGATGACAGTGGAGGAATTAATGTTGTTTTCGCTACTAGATATGCGTCAAACATGTTGCGCAGGACACATTCTCAGAATTTTGTGTTCCCGTGATATAACAATTCATTTTTCTGTCCCATATAACCTCTTTCAATTATAAGAAACCATTTGCAGCGAAACACAAACAATTTAGCCGATTTCTATTTCACCTATAAAATTCGCGTCAATGGCCCGCGCTGTCGAGATCATAAAACCATATGTTATGCAAATGGCGTAAAATTCAACGGTGGCCGCCCGCATGGTCATTGATCGTTATAAGCAGAATGGAGGAGGGTACGGGGAGCATCACTTTCCTGAAATGAGCCCGCGAGAGATTAGAGAATTAGAGAAATGAGAGATCAATGAGAGGGTGAAAGGTATGAAAATAAGAAAGGGATGTAAATGAACACGGATGGAAATAGATGGAATAATGAAGTGCGCAATCGATGCACCATCTCAGATTTTTCGGTTTTCGCGGCAGATAGTTGAGGAATTACATTTTTCGGGCTCCATCGATAATGCCCTGCCGGACAGCGCGTTATGTGAGTCTCCACAGGGGCAAATACCTTTAGTTTTACAATGCGAAACCCGAGCTGCGACAACGCGCCGTAAATCGCCCCCAGCCGTGACCGAAAATGGCCTAATTCGTCAAACTTTTACATTCCAAAATATCAGGGAAACCAGGTGCGCGTTTCCTGTTGTCCGAAAAAAGATTACAACAAAAGAGAAGAAATGGAGCATTTGCGCGCCATACACTTTGAGACAATTTCATTTTCCACATCCTATATATATTTTCGTTTTTCTGTCGTATTTTGTTGACTTTTAATTTATTGGTATTTCGACCGATTCAAAAATAATTATTTTGACTGTATTTTGCATACATGTAGAACTGGTGTTTTTTAAGATATTCGGCCCATTCAAGTTTTTCAGTGTATAATTGATATATGATTTCATTCCGAACTGAAAATTATATCGAAACGATGGAAAACCTCGGATATTAATACTGATTATAGTGGCAAGAAGAGAGGAATCGGAAAGTTCGTATGGATCAAGTTCACCGATTCTCGAAACACAGTCATCTGGCCGAAACTTGACGAAGTTACTGAGGATGAATATTCTAATTCGAGCAGTAATGAAACTAGCGACGAAGAGGAAAACCTCATACAAGAAGTACCAAAAGTCTTAGCTATAACAGAGAGGTAAGAATTGTGTCTTCTAGTGACTTTTCGCCAGATTCTCTAATATAATATATTTTGTTGTAGAGAGAAGAAAAGTTAACGGAAAACGAGACGAATTCGTTTTAACGGTAATCCTTGAAGTACAAACTAGCAATACTAAAAAATGCGTGAACGAGATCTTATTTTCAATATAATCATGGGCAAAACGATGAAATTATGAAAAGTCTCTTATTGGATACCGATGGAACTATGACTGCAGCAACAAGGCTTGTTCGGAATGTGCCTACGATTGGAATCAGTGCCAAGTTACTCTCTGGACTGGATTTATTAAAAATAATATGAGCTGCACGTGGCACTGCAAAAAACCGCTTCGCTTCAACAATGCTTCTTGTGGTTGGTTTGCTTTTCAAAAAATAGTTCACTGTTTCAGAGGTTCAACCAAGTCGCTTCTTCATGTTGAAAATGCGGTGCCCACCCGGACCATGTAATCGCTCTTCCGGAAACACATTGGCGACCGATTTTGTTGGTCCACCTCTAGTTCTGTGCGAGAACAGTGATACAACTAGTATTTTCAGGACAAAGGCTCGACTGACTGCGGAAGCTCCCGCATCTGAGGAGAATCTCAAATCAGGATTCCATTCCAAAGCGACAACTCGAACGCTTTCCAAAGATCGCATCAGAACGATCCACAACGTTCATCAGCCGAAGAACATGCGGAGCCAGATATCGTGGTGGATGGCTGAGTACGCAGCTCGAATGCCTTAAGGCGAAACAATTGGTTTTTTAATTAAGCTTGCTGGTCATGTTAATTTTGAACGTGTTAGTTCACATTGTTTTTTTTTTTAAATGTGTGTTGTTCTAATAAATTTGATTAATCACACGTTTTCTAGTCTACTACGTGCGTCACGAGATATCAGTGGTTTCTTCTTATCAGAAGCTGAATCATTTCCGGTTGTCAATGTTTGTAGGTCAAAAGAAAGGCTGTGTGATTTCGACCATTGATTTGTTTATATGGATAAGTTCCTGCCTTTTGGAAGGGCAGTATTCCCGGTATATATGGGCCTAATACGGAATCGAAAATAACCTGACACAAACCTGACGTTGCCTGTTGCCGGCGGCGGCTTAGTAACTTGACAGCGGGTCGCGATTTCACCTGCCTGTTCTCCATTCTGCAGCGAGCGACCTGCTGGCAGGTTGCCACTAAGCTGACGCGGTTTACCTGTGTTATGGCGCGTGCTCAGTCGTTTCAGGAAACTAGTAGCATCAGAAGATCGGGGTTCGGGAAACTGCCATCCGGGGCTTGAAGGTTCTATGAAACAGGGCGAATGACAAGGAGAGGCAATAAACAAGTAGTAGGCGTCCTCTAGAAAACATTTTTGTCTTTAATACGCGTTTCCTACTGATGCCTTATTTATTGATATTTGGATCCCCTTTTCTAGAATAAAAAATCAGAATCAGCAGAAAAATTTGAGAAAAAGTCATCGCCACTCAGAGTTGGTCGGAGTAAATCAGAGATAGGCATAGTAAATCATAGCTAGTCAGAGAATATCAGAGTTAATCCGGGTAATAAGTAACCTAGTCATAGCATATCAGAGCTAGGCATAGTCAAGCGTGGTTACTCCCAGTAAAACCACACTTGCACCGAACTGCGGCTAGTGTGCTTTACCTGTAACTCCGCTTTTTACTCTGAGTTAGTATGATATGATTTGTCTGAGCTGTGGTTGGGCTTCGCGGAACTTGAATAATTCGAGACAAAATCTAAAAATTTTAGCGAATTTTGTTTAATTTATTTGAGGTTCTACGACAGAACTCGAAAAATTTCGGGTTTTAATGTTTACACATTTTATAAATTTAAAATTGAATACTCAACTGTGGGACTCCTCGAAAATCACATGCTCATTTAAATTTTGAAGTTCGAACCTCAAAAAACGCGCAAAAACCAAATTCAGCTAGGATATCAAATTTATGATTGAACCCACATCTATATTTTGATGCGGTTTATAGTTTCTGAAGTTTTCGCGATAAAATCCGAATAATAATTACCCGTACCGTATATTCTCAATCTAATTCCCAGGTCATTTTTTCATGCAGCACTATGAGAGACTGTCGTTACTACTGGACAAAAGAGCATTAATTTTCGAACGGCTACTTTTAATTAAAGATCACTAGTATTTAGTCACAAAAGCTATTTTTTAAGCAGAAATTCATAAAAATGTTTTCAATAGCGAACTTTTGTAACCAAAAGACCCAGTAAAACGATTCAATTACTTTCGTCAATTATCAAAAAATCATCAAAAATATACAAAAAAATACCAAAAAATATTGAAACTTTCAAGTGACTCTTTCAATAGAAAATGGGGAGCACTAATACTGCTGATTTTTCGGACCCTTTTTGAATGCAGCACTATTAGAGACTGCAGGATTTACTACTGGAGTGATGCTGCACTAATAGAGAATATACGGTATATAATATATTCTTGCAGAAAAAAGTACGATTATCAATGAAAATTAGCTGATAAGAGGCTTTTGTTTGAACTAAGACGACGGAACGCCTCTAGTTCAAAAAATTCTAAAACCACGTTGTGTCAGGCATGTCTCATTGCGGTTTGATCTACGAAAAATGCGGGAATATTTTTCCAGAAGAATTGACGTCAGCACGCTCTTAACCATGCGAACCGCAGATGAGATGTCTGCGTCTCTTTTCCCGCATTTTAAGTTCAAAAGGGACTTTCTGACACCACGTGTAAAAAGGGGTTACGACGGACCCTGGCCTAGAATTAGGCGTGAAAATGCTCTGGCACTGATGTAGTGAACCGCGATGCAAAATTGGGGGCCGAAAATTAGGCTTTCCTTGCGAGAACGATTACTTAAAAATGTTTTCCTTTGTCGAAAATTTAAAAAACACACCACATGTATTCATCTCGACCAACGCCTCGTAAATGTTTTCAAAAAAGGCGGGTAAAATTAGTTGAATTCGCCAAGAGGAAATTCACCGCTGTTGAGCGCGTGCAAAAATTTCAGCACTTGCTGACGGTGTTTCCACAAATTACACCGATTAGTGGGGCAGAAAACACGTGCACACTCTTTCAATAAAACTAGAAAATAAATCCCAGGCCTGCATATATTGCACAAACCGTAATCCCCTTCGCGCTAAACAACACGCGCAACGATGCTCCGCTTGGGAAGGAAAAATTAATTTAACTCGGGCTTTTCATTAAACAATTTTTACATCGTTAATTTTTCGATGTTTTCACTGCGAAAAAGTGTTAAAATAACGATTTTTAAACCTATCTTCAATGAATCCGTGCAAAAAATCGCGATTTCTCGAGTTTTGAAAGAAATTTATGAAACAATCGGCATTTTTAATAATGGTTTGAAATAAAAATCTAAATTTTTTTTCGGTGCAGAAAAGTCGTTGCTCGCACAGTTTTTTTAAAGCATTTTCACATCAAACTCCGCCTTTTTTCCAGTAAATCGATCTAATATGTAGGGAGTGCGAGACAAAGCTGAGCGACGGCGCAAGCGGCTGGCTTCGCCGAGTATCCCGACAGATATCGATCCAAAAGACAGACTACTCGCCATATATCTTCCAGGCGATTTGGGCGCTTTCCAGTTGTACGGTAAATTTTCCGACTTTCAAGGTAGAAAAGTGTAGAAAAATCGAACTTACTTCTTAAAACTCGAAAAAATCGAATTCTTTCAGGATTCGGCAACTAGACGAGCTCCTAACCGACAATGTTGAAATACTGGCCAGGGGCCGCAGCCGCACACGATTCTTCTAGAATTCCAGAAAAGACCGACGTGGCTATGATGATGTTCTATTTGGATTTAAACGACGAGTCTTATACACCGTCAAAGCGCAATTTTTGGCTTTTTCAAACGAAAAAATACAATAAACCCTGAATATCCAGTTTGTTTCTCAATTTTTGCCTAAAAAACGGCTTTTTCACTCGCTTATCATTTACAATTTGAACAACAAGTTTTTTAAAGGATAAACATGAATTTCTAGCTTTTTCAGAGGTTTTCGATTAAAAAATAGAGATTTTTGTGATATCGGACGGATAAATTACCAAAGCTTGCTGTCGATTTTTTTAAATATTTTTTACTTAAAAATCTGCAATTTTTTTTTTCGAGGAAACATGTGAATTTCAAGCTTCAGAGATTTTCTATGAAAAAGGTTCGTGCCGAGACCCATGTGCTTTAAACTTCAGAATTTTCCCAATTTGAAATTAAAAAGAGAATGAAAATTGTCATGGAAAAATGCGTTTTTGGCCCAAAACCTCCAAAACTTCGAGTACAAATATAGGTCGAGTTTCAACTGTTTTCGATCAATTTTTTTGCAGAATTCAAGTAAAAATGGGTTAGCACCATCTCACGATATATTTTTCCGTCAAACACAAACATTTAACGAGCCCCAGGGATGGACAATTATCGATTTACGCGAGAAAAATGGGAAACCGAATTGCGTTTTTTGGCTTCAAGTATTATTCAGAATGATCAAAATGGCAGAGATGCTCATATAACGTAGACGAATTGAGAATTTCAGAACGAAAATTGCCGAAAAAATAGAAATTTTAGCGAATTTGAGTCGGAAATTTCGAAATGATTGACATTTTTAAGCAAATTTCCAACTAAAATCTAATATGCAAATTTGATCTGTTTATATTTTTCTTTAATTGTTCTAAAAACCTTAATAAACAATTAAAAATTGAAGTAAAATTAATTTTTTAACTTTGAAAGGATTTTTTGATTGAAAATTTTCACAATTTATTTTGTGGTGGGGCTAATTAAAATCGTTGTTTTTTTTTTCAAAAAAGTTAAAAAAACTTTAGTCAGAAATTGCCTTGTAAAATATGTTTTTTCTCTAGACCTCGTAGTCACGAGGACGCGTAGGTCGCCTCGCAAATTTGAAAAACTCAAGAAAAATCAATAAATTTGTGATTAATCAAGAAAAAAAATTTAATTTCCTGGTCTCAGACACGAATGCTTCGAAAAAAAAAAAGAGGCGAGCCTACGCTAATATAGTTGACCACGCCCACAAAATGGGCAAATCAAGTTTGGCACAATCTTTCAAAAAATCGAAACAAAAATTTTTCCAATTTTGTGAGATTTTACGAAAATTTCCGTTGGAAAATCGAAAAAAAATATTCTCGTTTTTTATTTTTCAAAAAAAAATGTGCCTAAAATTCATAAAATAAATCAATACTTTCTCAAAATTTCAACAGTCCATCTTCCAGGCACGTTCAAGAGTCCTTGGACCCCATCAGGCGATGTCTCCACGAACGAATCGAATATTCACGGGAGAACCACACGGACCGATTCCCGATAAAAATATCAATTTCGACGGCTAGGATTTTGCCAATTTTATCGATCACTCACTTCTTCACTTCGTTACATTTATCCGCCTCCAGTGATTCCAGATAATGAGCCAGTTTTGCATTGAAATTTAGTGCGAAAGGCCATATAGAGCATGATTTAACATAAAATTTCGAATTGATAAACAATGGAAAAACATGGTGCTATGATGCTTTTTTAACACTTTTAATTGTTCCAATTTGAGAAGTAAAATTTTCAGCTGATAAATCAACTGATTTTCTATATACCTCTGCCACTAAAGCTTAAAAACTTGCCCCAGTGCTGTCCTAACCTTCAAATAGCTGGCAAGTCTATTTATTATTCTTGTTTCATACTATTGAGATTGCTTCGCGAGACCCCAACCCATTTACCTGTAGTTAAATATACGAATAATTATTTATATATTTTCTTTAAATTTCCTTAGTATACTATTTTTCTGATCTCTCTTCAAAAAACGCTAGAAAAAATAAACAAATGTCGGTTTAAAAATGCCCGGTAATTTACCTTCTATAGTTTTTCGAAAAAAAAACCGATGAAATTCAGATGGAAATTCCCGATCCCGAACTGCCGGGAACACCGGTTGGTCCGCAAGATTTGGAGATTCTAGACACGCCCGGTTATACGAGAAGCTTAGTGCGTTTCGTGTCGGGACCCGGAAATTTGACATTTTTGGCGCGCGGCTTATTAGAATAACTCCAAACCTTGTCAAAGATGTTTTTTTCGAATTAAATAACATTCGTGCTTGGGCTCGGATATTCACAGAAATTTTGATTTGGAAACAATTTTTTTTGAGGCCAAAATTTTCAAAGTTTGTCTTGTTGGCGCGTGGACTAGTAGGAACCGCCCCTTCTAAATTATCCCTGTATTGAGCAAGTTTTCTGACATTGATTTCAAAATTTTTTTTTAGAAATTTCTGGTTTATTTTTTCCGGTTTTTTTCCGAGTTGCTGTTTAAGTTTGGAGAAATTTCAGAATTTGTCAATTTTAGGTGCGTGGCAATCTTTTTTCAGTAACTTTTTTTTTATTTGAAAAATTGAAACTTTCGCGATGCGGTTCAAGTAAAGCCACAAAAACTCAATGATTTTTTCACAAAAATTTCAAATTTCTTGCAAGACCTACTGCAACTTCGATTTTTAGAAAACTTTATGCTTAAGAAAAAAAACAGCGCGAATTTTCTGATTTAGCCCGACCCGCCCCAAAAATGGAAAGATTTCCGAAAATTCGAACCAAAAGTTCGCAGAAACTTGAATTTCTCTCACACAGAACGCGCTAATTTGAATTTTTCCAAAAATAAGCAAGCGCCCGCCCCAAAAATGCACAAATAAAAATTTTGAACCAAATAAATACAATTTCGCTTTTTTCCGTTTTCGAACAAAAAATTCTAAGTAAATCTATGGTTCTCAGGGCCCAGGCACCCATCTACCTACTTAAAAAAGCGTTAAATTTCAGGAATTAGCATCAACCGAACGCGCGTCTCGCAGATTGTGTAGTCTCTATTTGGGCGGAGATCTCGAAAAAAATCTATCGCTGCGATCAGAGATCCGAAAAATCCGTGATTGAAGTCACGATTCTGTTGGAATGGGAACACGGACCAATTCAAGCGGCGAAAGTAGTGTAACAGTGCTGAAACCTATTTCGGAAAAATCAAAAGTTGGTCTCTTTTTAGCAAAAAAAAATCGATAAATCGATGAAAACCGACAACTTGGAGAATTTTCATTTATCTCAAATTTGAGTCCCTCAGCGCCATATTGTGTACTGTAGGTGCTCGAATGTTGAATTTCAAAAATTGAGAACTAAAGACATCAATGTCGTGACGAGACAATGTTTTGAAAATTTTGAATTTCAATGTAAAAAATTGGGAACTTCCCTCCAAAAGGTAAATTGGTTTAGTCACAAACTCTGAAATTTTGAAATAAAATTTTTTTCGGCTAAAAATAAGTATTTTACTTTAAAAACTATTTTGAAGAAAAAAAGTTGGGTCTCGCCACGTTGTATCTTGTATATGTGTATCTAAATTGCCATGTTGTCGAGACCCTCTCCTATTTTACACTTCAACTTGTTCCTCACGAGGGACGAGGAACAGTGGTTTCTAGGCCATGGCCGAGGGGTTTCCGACAAGTTTCATCGGCCATTTATCTTGCTTTGTTTTCCGCCTGTTTTCTTTCGTTCTTTTTCCCATTTTTCCTTAGTAAAAAAATAAATATTTTTGCAGATGCCAAACGATTTTCAAGTAAAAAAATCATGTATTCAGTGGGCAAGCAGCGGTATGAAAGTTAGGGCATTGTTGATGTATTATCTTACGGGAATACAAAACCTAAACTTTTGCTGAAACATGATACATATGATGCTTAAACTGACTACCTGATCTTCTTAACGAGACCGCTGAAAAAGTTTTGAGGTTTTCAAAATTCAACTTTTTGTGCGAAAATCTCGACTTTTTCACCGAAGTTGAATGGAAACCTCAAAACTTTTTCAGCGGTCTTGATATGAAAATCAGGCCACTAGCTTCAGCATCTAAGCATCATATGTAGCATCATGTTAAAGAGAAAGTTGTTTTGTATCGTTCCTGTAATCTGTGGCATCATATTACATTGCCCACTTTCACCGCTACTGCCTGCCCACTTAATACATAATTTTTTCACTTGGAAATTGTTTTAGCATCGCAAAAAATATTATGTGTATTTATCAGTTTTATTAAGAAAAAACGAAAAAAATCAGTGAAAAACGAAAGAAGACAGGCGGAGAACAATACAAGTGTGGATAAATGGACTCTGGAACTTATGCTCGGCCCATCCGCCATGGCCTGAAACCACCTTTTCCTTCGCCTCGTAAGGAAAAAGTTGCAGTGACACTTTTACTCAAATAAAAAAACAAAAACCGATAATTTCACCATTTATCAGGCACATCTCTTCCTCACACCGGACCTTAGTGCTTAAAACGAGGCCAGTTCTTCCACAGCGAGCCGACGAGATTCATCGGTCTCCAGCACATGAAATTATACATTTTTGCTGACAATGTATTGATTAGTGGGTTAGTTTTTAGTTGTTTGCATGGGTCAGACTACAAACGAAAACCCTAATTTCAGAGCAAATTTGACGGATTCTTATTTTACTAATCGAACGGAGCGATATTACGTTCTATTCAGAAAGTGCAAACCATTGGCAGATTTCTTCCACGCAATTATCAACATAAGCGTTGTTGGTGAGTTGGCGATTGCGCTCCACCGACACTGGTCAGCTCGCTTGAACTGATAACTTTATCTAAAAAATTGCAATAATTGTTTTAATTTGGCTTCAAAAAACCATCAGTAGATGTAATAAAATTCTTCTCAAAGCAAAAAATTAGATACTTTCTAAAAAAATTGAATCTCCCGCGAAAATAATTTTTTGAGAAAATTTGAATTTTTCACCTAAATATTTTTTTCAAGATTTTTTACCACAAAATGAGGCGGGGCCTCGGTATACACGCTCAAAAAATCAAGGGAAAACTTAAAATACTTGTAAATTTGACTACCAGCTATTTTTTGCGAAACAAAAATCGAAAGTAGCACTTTTCGAAAAATTCTCGACAAAAATGAAAAATGGGGGGGCGATCTGTGTGCGGCGGTATTCGGCGGCATATGCCGATGCCGGTTTTTGGAGCCCGTCATATGCCGTTATGCCGATTTGAAGATTCACGGCATATGCCGAAAAAGCCGTTATGCCGAAAAATCCCCCGATGAATGCCGCACATGTCTGGGCGGGACTTCAAAAACCACGCCCACAACAGAGAACAAAAATTTGGAGTGACGGTTTGCAATTCCCTCGCGCTTTTTCTTGTTTTTTTTCAACAAGATGAAAAAGCGCTCTACTGACACATTTTTTTTCTAATATTTTCATTATAAATCCAATTTTCAGCCGACTCGAGCTTTTCATTGTCGAAATTGAGCAAAACTGGTGCCGAGACAATGTGATGTGCACACATATTTAGGTAATCTGAAAGGATGGGTAACCTGAAATTTTTCCAAAAAAATTTAACGCTTCGTTCGTCTCATCTCTACCGATGCTCAAAACACGTGTGAATCGACTTAACGAAAAATACAAAGAATCGCGAAAAACGTCGTCGAATTGCATGTCTGCTCACACGTGGATTTACCCCGTTTTTCAAATGGGGCATTTGGGAATCAGGAGTTTGAATTAGTAGTTTGCAAAAACTTTTATCACTGAAAAATCCGGAGCTCAAAATGACGATGGCTGCGGGATATTTCAATTTGGCTATCGAATTCGAGATTATGAGGAATCGATTCTGAAAGAAGGAGATTAACATTTGGATATGAAATCTTACAGCTTCTCCTTTTGTATTTTTTTGGGAAAAATATCTGAAATAAGTTCAAAAATTTCAAAATAGAATTTTTTCGAAATTTTTGTACTCCTGGAAATTTTGGTTAAAAAAAGTTTTCTCGAGAAATTTGATTTCCCGCCAAATTTTTTCTGTGAAAATTTGATTTTCCAACATGTTTTCTCATAAAATTTGAATTTCCCGTCAAGATGTTTCTGAGGAAGTTTGATTTTCTCATCAAAATATTTCAAAATCATTTCCAGGCGAACGGATTCTTCGATCAAAGTGGCTTCTCGGAAATAGATTCCACCACTATATTCCAACATTTCTGATCAATTGAAAACGAGAAATCAACGGCCGATCGAGTGTGAAAACGTTCGAATAACGATAGAGAAGAATGGACATTTCATGCAAAAGGTTTTGTAACGGCAGAAAATAATAATCAATTAACGACATTAATTGGCTCATCTAATTACGGTTATCGATCGGTTCATCGAGATCTTGAAGATCAAGTGATGGTTGTTACAAGAAATCGGACACTTATCTATCGATTAACAGGAAAAGAAAAATCTATTATTCGAATATTAATCGATACTTGACATGGCTGCACTTCAACAACCGGAACATCATAATTCCACCATTAGTTCGAGTCATTTCACGTCTAATTCGGAGTTTTTTGTAGACGTTTTCCAATTCTTTATAGCGGAATAATAAGGTTTGACTTTAATAAATCTTTGTAGATTGTTACAGTTTTTTTGAAATGCAACATTTTGCCGAATTAGGCCATTTGACAATTTTTGGTCGTGTCACGGCGCGGAGTAGAAAACTAAGTATTTTGATTTGTTTTTTCGAAATATCCGAAAAACAACAAAAGGAGTTTTTTGTTGAAAAAAATGTTGCGAATTTCAGAATACGGCACTTTTCCGATTTCTGCCCCCTAGGGCTGTTATGAGGGGGACGTCCCCTATTGGGGGCCGGGGACGATCATTTGTACCCCCATGGGGGACGGGCGCTTGTCCCCGCCACGTGACGGGGAGCGCCCCTTGTCCCCGATGGAACGAAGATTCGTCCCCTTTTGAGTTCTGATTTATTTTAGATTTTCACTTCATATCTTACCGGTACAGAGAGTGTAGATAATTCGTTAGAGAGTAGACGTCCGGGACCCAATGGAGCGGGGCGCGCGGAAGAGACGATCTAGTGTCGATTTACGAAATTTTCAGCAACTCGTTGTCATCATTTCGTAAATCCACACAAATCGTCTCTTCAGCTTGGGTCCCGGATGTCTGGCACTCTAACTATCTACACTCTCTGTACCGATAATAAAATATTTTTCCGTGACTCGTTTCCATAGCTTAGACGCTGTGTGCGGGGATACCGTGGATATTCCACACAAAAAACGTGTCGCTTTAATAATTATGAAGCAAAAAATACAACAAACGCACATTCTTCACATTGGGTAAACGAGGGGGCGCGCTCCCACTTTACCCGGGCGCCCCTTTTCGGGGGGGGGGGGGGGGCGTATTACGGGAGGTTTTTTGAAAAACTTGGTAATTTTTGAAATATGTCAACTGACAGCTGTCGTTCAAGTATGTATTTCTATCATATCTCCATACAAATCATAGTTAATTCTTTAGCAATATTGGGGTCCCTCACAAAGTCCAAGTTTTCTTCTCACACGGCCGCCTTCGATTTTTTCTTAAGAGCTTCATTTGCGAAGATCAAAATACATGATCGACAAAGTTGAGTCACTTAAACATCATCATGTGTGTTCGCCTGCAAATGTTAACAAAGGACCAGGCGAATTTGCCAAGCTTTCACGTCTTCATGTCTACGTAGAAAATGCAGTCCTTGAAGAAGCCACGCAGACAGACAGGCAAGTACATAATCAGTAAATGGGCAAATAGGCAAAGCAGGCATGAAATAGGTTAGGCACGTGGGTAGGCAGGTATGAGACATACAAACATGCAGGCAGGTCTGAGAAAGCGAGAAAAGGCAGGTGAGCATGATGAAGGCACATAGGCAGGTAGGCAAGGAAGCTCCTAGACAGGTACAAAATAGATGTGCGCAAAGTAGGCTGCAAAGAAACTAAGCTCGTCCCCAGGCATGAGGTAAGCGCATAGGCTTGCAAGTAGGCGAGTAAACACGCGGGCATCAAATTGAGGCAATCAGGTATTTTTGGGCTCCATTTGGAAACACACTTACTGGATAGAAAAGAGTGGGACTCGTGTAGAATGCAAATGCTATATAAATTGGATCCGGTGCAGCACAGATTTTCTCTTTGATCTCGTTTGTTCAATCCGTAACTCCGATAATTGATTTCTCCAGTTTCACTTGTATTAATCGCTTGGAGAGGCTCTCGATGATAGAATGAAAAATACTCAGAAATTGTCGGATATGTTCTCGATTTTCAGTGAATTTCCTTAGAGAAAGCTAAAAACTCACGAACAAACGCTGCCGATCGAGTCCACCACCAGTATTGCCTACGCCCCACAAAAACCGGTCTCTCGCTGTCTGTCACTAGTTTCAACAAATACCTAATCTCCTCGGCATCTTTCGGTCCCATATGCTCCGGCCATCCGGTATAATGGTAATGAGTCCCCTCTTGAGTACGCTACTTTCTGGAAAAAAGTTTGTTGCAGGCTACCTTTTAGGCCATACTGCATGGAACAAAAATACGGACAGGCGTGGAAGGTTAGAATAGTGATGAGAAAAAATGAAAACAAACATTTAAAAAAGCAAAGAATTGACCGGTTATTATTAAAAAATAAGAATTTTTATCCGGACAATTCGAGGCAGATGTGACTGCCTACCGGCGTGCCACCGCGCCTATCTCATGCCTGCGTGCCTTTACTGACTCCCAAATATTAGCAACAATTGTGACCTAGTCTTCAACAAAGGGTTCGAGATACTCTTCGTGCAAGCGATTGTTAAGTCGCCAAAATTGGTTTTTCGTCGAGTTCAGTTGGAAAGTACCTATCACAGTTCACCGTATTAGCACCAATAAAGTTGAAAAATACGATAAATGGATTGAAAACGAAGGGTGGCTTGAAGGCAGGCAGGACCACTGCTCTGTGTAGGGCGTCTTGTAGACAAGCAGACAGGAGTGGGTCACCATGTAGGCAGAGGGAAGGGTAGGTTGGCTAGTGGGCGGGCAGGCGTAGGCTGCTGCAACACAAGCATATAGGCTCATCTATTTCCGCGAAATCCCACAACAACATCACAAATGTACTTGATTTATTCAGCTTCACTGACTCCCAAAATGCGGCAATCGCTAAAATATCGGAGCTTTTCTTATCAACAGGCTCAACTGCGGAGCAGGCATCAACACAAACTTCAAGCCGTTATCCACTTCAACAACATGTGACGATGCTGGCTGAAAATGAACGGATTTTTTGGGAGGTACCCATAATGTTGCCACTTGTCTACCTATGTGCGCTTGAGTTAAAGGTTAAACCTAAGCCTATGCCTATGAGCCTAAGCTGAGCCTAAGCTTAAGGTTAAGTGTAAGCCTAAGCGTAAACCTAAGCAATGAGGCGAAGGGTAGGCAGGCAGGCGTACCAGTCTTACCCATTCTTTTTCGAAGACTCATAGACACCGGATCACAGTGACATCCTGTAAGGCGCAAAACTGGACAAAATCGTCTCCCGTAATTTCTACTCTAGGTTATTTGGAACCTTCTCAAATACTGACAATTTTTTCTAGTAACGAACGAAATTAGCGTGTTGAATGAGTCTTGAGCGGCCGAATTGAAAAACGTATCTCATTCAGATCCACACGACTGATCATCTGATTTGGTGGGTACATCGTTTCTCTTTTTCTTCCGAGTCGAGTATTTTGTAGCGGAAGCAAAAGGAAGCAATTATATATGACAATGACGATCAGAGCCAAAATTACATATTGTTCGTGTGGTCTGGGATTTTGGAAATTTTTAGGGATGTTCAGCTTCTAGGCTTTGTTAGCTTAGCTTAGGCATAGGCTTAGGCTTCGGCTTAAGGCCTAAACACAGAGGTTGGCGGAACCAGGCAGGCAATATTAGAGGTACCCGCCAAATATCTAGAAGCTTCACTAAAAAAAAAACGTTTTGAATCTAAGCATGAAACCAATTTTGAAAAAGTAAAATGTTTGCTTATCTCAATTTTTGCATTTCCTTGCTTTTATATTGTAATTAAAAATAATAATTTGAATTTTCAGCTCGTTCAGCGATAGAGTTGTGCTAAATTTCAAGAAGAAATTAAGAATTTTCGTAAAAAATATTTGTTAACGCGAAAAAACTTTTAAAGCTTTAATTCATATTGTTCAAAAAAGGTTGGAGTAAAAAATTTGGAATTTTTTTGATTTTCACCCCAAAACCTTTCTTTAGAATGTATCCCTCTTGCCTCCATCCGCGCCTTATACGCAATCCGCGCCTGATGATTTTTCTCCGGGAACTTGAGAAAACCGATTTGGTTGTTGGGAGAAGAAGTGCGGAATGAGGAGCGTTTTTTGAGAAAAGATAAAATTTGGGATTTTTTTGATCATACTTTCCCGAAAACCTTTCTTTAGAATGCTCTGCCACTTGCCTCAACGCCTTGTGATTTTTCTCCGGGAACTTGAGACGATTTGGTTATTGGGAGAAGAAGTGGGAATGTGGAGCGTTTGCTGAGAAAGATAGATTTTCTACTATTTCTCAATTATTCAATACTATCGAACTTGATATGCAGTCTTTGAACGTTCTTGTCATTACGAGTAGGCGAAGGTTATTGGTAAGTGTATGGGATGTCTTTCCGATGAATTTTACCAACGGCACGGGATGCCTGAGTGTACCTTTTCGATTTCATAAAAACTTCGGAAGGTGTGCTGAGCGTAGGCGTAACTCGTTAAGCTAATTTTTCCTTTCCTGGTAAATCTTATCCTGATCAAACCAGTTGGGAACACTGTGGCGCCACGTGCAACTTCATGGGTAGGCGGCAAACACCACGGAAATTTATGGATTTGGGGCACCCAATTTGACGTAATTTCGGTTTCCGAATTTTGTCGGTGCATTAAGGGTTTGACACTGAAATCGAGTTTGGGAATTAGCGTTTTTCAAGTCGAATACCCTCAAAATTTTGGTTTCCGCAAGTTTGTCTAAATGCAGGGGTAGGCGGCAACTGCCCTTTGGCATATTTAATTTTGGCACGACGAATTCACCCAATTCCCGTCAACGTGAACTTTCTTCTCGTTTCTTAATTAGTTTTTCATTAAATTGATAAAAATGAGAAAATTATAAATTTGTAAATTCACTTCAAAATGCAGGCGGGCAGGTTTCAGTCAAGCCCGTCTGAAACCGCGCCTGTCTACCAAGGAAGCCCTACACCTTTCAAATAAGATCAACTCACTGTGGTGGTGTGGACCATTCTTTTCAGAATTTCCAAGATCTGGCGGTGGTCGGAGAATTGCAGTCGTGGCAGAGGCTTGAATAAATATGAAATGAGCAAAGCAAGTCCAGAGCAGCAACAGGGAGCCTTTTTCGGCAAGTCTGTTTTGAAAGACTTGAAAACTCCAGTCCACCATCATCCAAGCTCGTCAGAGCATCCTGAACTTCACCGAGCAAGCGACTTCTTATTGCCAACATCCTTCACAAGTTCTACCGGTTTTTCCCACGATTTTTCCAAGCCTACCCTACCAAGACTAGCCCAAACAACCTTCTTAGCTTCCGTGAAACATAACCATATCTGTCTACAAATTCTGTGGAATCAGATTAAGTCCACTTATGCATCTAAGCTGAACAACATCACATCCAAAGATGCTCCAAGCGCCACCTCAGCTTCTCAAGATGATCTATCCTTATCGTCCTGTGCCAAAGTGGCTCCACTCGCTGCCAACTCTCGTTGCACAATTTGTGCATGGTTCTAATGATTCCACATTTGCTCTTTATTCTCGGAGCACGTCCTCCAGTCGAGCAATTTCTTGAGCCGCTGGGCCATTATGGAATTAGTGTTCAGCGCCGTTTGTAAACTGGGATGTTTTATCCGAAGCAAATTTGCGGCGCTTGCTAAACGTACAGCGCCAGAGATTTCAGACCACTATTGAGGCTTGAAACTGAGATCAGAGCATCTTCGACAGCAGTGGCTATCGGCAGGAATTTTTGATCTGTTCGGAACGAATTCAAATCTGACAGGTTCTTTTTAATTTTGGCCAATTCTTTGTTGGTCGAAGCCAGCTCTACGTCGGAAGAAATTGACCAATATCAGAGCGAGAGTCATTCATTTGTTCAATAGCACGTTTTTCTAGTGTTTTCAAAAGATTCGGATTCACGAAAGTAGCGTTTGCCGTCAACAATTCTACTCATGGTCAGCAACAACATTAGCCGCTCATTTTTTTCACTCCATTAAAGCATGGGCGAGCCTCAGCGGTTGTCCAATTGCTATTGTTATCCTTGCAATCAGTGCGCATTCTGCGTCCTGATTTGCTTTCAACAAGTTGATTCATCACACTTTCAAAATCGATATCGATTGTTCCCTCAATGTTCGATGCAATTTTAGATAGTCCCTCCAGAGTCGTGAAGTGGGGGGTTATTAGATCAGAGTAGATTTGGCGCATTGGGCTGAAAGTTTATTTGTATTTTCGTTTTTTTGAGTTTGAACCTTTCTGGACAACCGACAGATTGGCTCAAACTAAAGGACTTTACAAAAGTTTTTGTCAAATCAATTTCGCAAATATTACCGGTTTTTCGGAGCTTTGATCAGGGTGGGGTGGCAAACGATTTTTTTCCCGAAATCGGCAAATCGGCAACCCGGCATTTTGCCGATTTTACCAAAATGGCCTGGAAAATTTTTGAATCCCTCCCTCTAAACACTTCCGGTAAATTGTTATCCAAACTACAATTCGGCAAATTACCTGAATTAAATCAATTTGCGCCCAATCGGCAAATTGCAAACTGCAAATTACTCTCCGATAAATTTGGAGAAACCGGCCAATCGCCGAAAATTTTTGGTAACTGGAAAAAATTTCAAAAGGCACTGTACCCTTGCTTCCGTTTTGAAAAATGCTTCTAAACAGTTCCGGCATATATCCGGCAAACGGCAAATCAGCAGTTGGCCGTAAAATAAAAATATCCGCCTCAGCAAATTAAGGCTGGAATTAAAAAGTTCCTCCAAATCGGCAAAACCGGGAATTTGGCCGCGTGACTTCGCCAAAAATAAATATGCCAAACGGCAGTTGCCACCTACCGCTGCAATGTTAGACAAACTTTCGGAAACCAAAATTCTGAAGGTATTCGACAATTGTTTGAAAAACCCTAATTCCCAGGAACACGACTTTATTATAAAACACTTAATCGACAAAATTTCGGAAAGGCCCGAAATTTCTGGCATATTGGGCAAATCGATAAACATTTTTTTCCGTTGTGCCGCCTACCCCTGGAGTTGCACGTAGTGCCACAGTGTTCCCTATTGGTTCGCTCAAGAAATTGCGGACTTGCCAGGCAAAATTAGCTTAACACGCCGAGTACCTCGCTTAGCTCACCTTCCGAAGGTGAAATCGAAAGGGTACACTCAGGCTTTCCGTGCCGTTGGTAATTCATCGGAAAGCCACGCATACACTTACCAATAGACCTTCGCCTCAGCGACAAGAACTTTCAAAGACTGGATATCAAGTCAGATCGTTCGATAGTATTGAATAATTGAGAAATAGTAGCAAATCTATCTTTTCAACAAACGCTCCACATTCCGCACTTCTTCTCCCAACAACCAAATCGTCTCAAGTTCCCGAATTTGCGTAAAATTATGTGATCAGTACTTTCTCGGGCCCGAGCGTCGGTTGCCAATTGAGAGTTTAGGTTATGCTCCATATCAATTGCTCCATTCGGTAGACCAACTGTGTACTTCTTCGGGACTGCCCGATGGATTCGATGGTTTGAAGATGGATCTTCGATTCTTGGATATATTTGGAAATGCATTCCGGATAGATGCCATGTTTTCTACTAGCTTTCTTAGTGCCGCGATTGCGGGATCCCAGATGTGTACAATCTTGATGGGTGAAAATTATGAGTTCATCACATCACGAACTTTTGGCCATAATACAAAGAAAGAGGAGCAGCTATTGTTTTTGAAGCCATGCATCGTACATATTCGGATTCCCACTACAATCTTGGGATTTTTTCAACAAATCGTTTAACGCAGAATGGGATTTGGGAATCTCGGTAAACTAGTGAACGCTTCAATCTCTATGTACAGTTGCTCCATACTGAAAGCATTTCGGAAAGGGTTGTAACTTATGTAAAACTCTCTGTAATGTCTTTCATGTCTGCCTTGAAATTTGTCTCGTCTGGCCACTTCTTGGGACCTCCAATATCATGAGCCAGGTGGGGGTACCACACTTTTGACAGTTGTAAGGCCAGAATTGTTTTGCATCAACATCGTCGCCGATATTCGATTGTAGTTCTATAAAGGTATAGTTTTTGGGGGCAAAAAACGAAAGTGGTTCAAAATTTTGGAACATAATGCCTATTTTTAGATAGCTAAAATCTAAAATTTTGCATTGCTGACAAGCTTGTGAAAATCGGCTTGTTTAACAGAAAATAGGCTTTTTCCTATACTTTGAATTACTTTTTTAGATTGAAATTAAACTCATTTCGGTTATTTCCAAACGTCCACAAAGCCGCAAACTCTATCAGGGGTAGGCGGGAATTGTAGGCAAATGTATTTTCTGCAAAGCTAATCGGGATGTGTACAATTTTGCCTCTGGCAGTTTACCGAGCCCATTTACCGAAAATTTTAATTCCGGCAAATTGTCCATACTCTATTACTACATAGGCCCTTATATAACATCTTTTTCCGCCCCTCTACTCTATTACCACCTAATCTGTTACTACAGTGGATTTTTAGAAACCAAAATTTCAGCTTTTGAATTTTATATTCGTAGAGATAAGAAATTCGTAGTGAAAAGTTGAAACCTGGAACAAACATAGCTGCATAATTGCATCGTAATATGTAAAAATAGGTCTTCCTTGGTAGATAGGCGCGGTTTCAGGTGCGCATGCCTGAAACCTGCCTTGGGGCCATATGTGAACGAGTAGACTGTAGTTTTAAAAAACAAAAAAAGGTACCTAACAAAAAACATTCTCATATATTAGTTTGAATGTGCAACCAAACCTTTGAGCGCTATCAGTTTAGAATTTCCAGCCAGAACTGGAGTCAATTGCATTCAGTTGATCCATTGAGATATCGTATTTGAACAAATCCAGAGTTAAATTCGTTGATGGAATGGTTCCTTTTGTGCCGTTCAATTCTTGTTGTAGTTACATTGATCTCAATCGTGAGGAGAATTGTAATCGTGCTCAACGGCAGTTATGAAGTTGTCATCTGCAACTTTTATGACTGATTTTTTTAGATGAAGTTATTTGTTGTCTTTTCTTTTATGAATTATTACGTATATAATACGTATCATGCGATATTGTTTCGCTTTCCAACCCCCGGGGAACTCTTTTTACTTTGTTTTTTTTTGACTTTTATGGACTTTTTTGTCCTTTGCTATTTTTTTTATGAGAATTGATGCCCGAATTTGACTTTTTTCAGATCAGATTTTTTGGAATTTCTTCGCAGAGGAGAATTATTCTTTTTTGTCAAAGCGAGCTAACGACCTAGCCACTGACGCCAAGCCTAACATAGGACTGAACCTTCTAAGTCTGGAAGTAGCCTAAGCCTACAAGGAAAGTCTTTGAAAGGGCACTGTAGATTTTGGTTCCTCTCATGTTGATTTTCCGATAGAAGTGTGTGTTTTGATCTATCCAAAAAATTTAGATCCAAGCCAAGTTTCAGCAAAGTAATGACATTTCGAAATTTCAGTTAAAAACACCATTGTGAACTGTCTTACAGTGCGATCCACACAAATAGCTCGCGTGAACACCAAAAATGTGACGCCCACCACAATAGGCTGAAGACAGTGGATTTCAATGCTGTTTTTAACTGAAAATTCAAAATGTCGCACTTAAGTTTGCTGAAACTTGACTTGGGCAGCTAAATTGATTGGTGAGATCTACCCAAAGCTAACACTCTTCTTGAATCGGAATATCAACATGAGAACCCTAAATCTACGGGCCGCTTAACCCAGACCTCCCTTGTTAGCACTAAGCCTATGCGAGACACGCAAAATATACATTAACATACATATACAACAAATACAACGTAATAATTGTTTTTCTGTAATTCGCTGACAAACCTTTCCAACTACGTTGGGAACGTGGATCTAATGGCGGTCATCACATTAAAGAAACTGGATTCTTCTGGAGCAACATATATTGAAGTTAAACCTCCGAAACAGTCAAGAAACCTTCGAAAGTATCCGAATTGACAACACGATTAACCGTTATAATTATCAAAACGATTATTATTGATTCGAAGACAGAAGACAAAATTCGGAACCAAAATAAAAATCAACCTACTCATTGCACCAAAATATTATGAAACTTCCCTTTGATCGACGGTTTTTGAAGCAATTAAAGATTGGAAGTGTGAATTCTGAGAAAAGGAGTGTTGGAATTTTTATTTATTTTATAACGAAAAGGTCACGCGTTTCTGTAATTTAATTTCTATGAAAGTTTTAAGGTCTCACAGAATGTCAAACACTAGATGGCCGAAGAAAATTTGACATAAGCAGCGAAATTTGACCTTTCAAAAAAATTAATATTACGTGTACAAAAATCTTTGATTCCAATGGAACTGAATTTTTGGGTGATACAAGAGGGAATGTGTCTCAAGGTGTAATTTCAGTAAAACTGTACAAGAGAAAAAACGTTCAATATTTTTACGCCGTCTATTGCTAATAACTTCTACAAAATTTTCATTCGGACATAACAAAAATAAAACAAGGTGACCATGGGGTGAGATTACAGGTGCATTTCCTCATCTTCATTTTTCAGACTGAACATCCAAGATAAGTAGCCCGAACTGAAGTTTTTCTGAAAATGTTATATAGTCATTAAACATCGGTCAAAAACAGTATTTAAACAAAATATCCCGAGACAACACACCTTTTTTGTCTTCAAGATATTCAGATAGAAACCTAATGTCCTGAAACTTGGATTTTGGGTCCTTAAGAAGATAAAACAGATAATTAGCTGTTTTAAGTTAATACCCGCAATCATTTTCACATTAGAGCAAAATTAAATTAAAATGAAACTTTTTTTTGGATTCAAGCATTTTTTGGAACCGAAATTCAAGTTTTAGGACACCCTAGTTTTCAACCTGAATATCCTGAAGACAAAAGTGTTTCACCATCTTGGCATTTTTTGTTTAAATACTGTTTATGAATGTTTGATGAGTATTTAGGAACTTTTTCAGAAAAAAATTCGGGCTATTTTTCTCGGAATTTCAGTCTGAAGATGTATGATTTTTTAATTCAAATTTGAGGGAATGTCGTTCATGGTGGCTCGAGGTCAATGGATAAATGGCTAAGACTAAAACATCGACATTGATCGAAGAACGATTTTTTATTCAAAAAATAAGATTTATTTGACTAGCACTGAAACATTCATCGTTTTTTGTCACTATAACCCATTGGAATGATCTGTAGAAATTAACTAAATTTAGAGATTTTACCGATACGTGGCAATATTTAAGACATTAGTTTTCGCCCTGGCCGTTTGTCTGTTGAGATAGTGAAGCGCCAGCTAAAGCGCATCGCCTTTGGTGCTGAGAAGCAGGTCTCGACGCGACGACATCTTTCTTCGCGCGCAGCGGCGAGATTTCGTCAGTACGTGTTGGAGCGTATAAGAATAAGGACGTGATTTTATCGATTTGCATCGATTTTTTTTGGATTTTTCTTTGTTATTGTATTTTTATCGAATTTTTAGTAGTTTTAAGGTTCTTTTTTATCGATTTTCCTTGGTTCCGTTGTGTTTTTAAGCGTTTTTCTCGTTCGTAATGATAAAAAGGGCGGTTTTCTCCGTTTTCCAAGAGTTATTTGGTATGTCAGATTTTGCAGGAGGAATCATCAAAATTCTCAGTTTTTGGCATGTGATCCTTACGAAGAGTACTGTCTGATGCACATCAATGGCTTTTTCCCCCGCAGGTGCTACAGTACGTGTTCTACTCCTTTCAGGGGTTCCTTCTCTCTTCTAGGAGATTAAATATGTTCGTTGTTTCTTCCCTCTATCTTACGCGCTCTTTCCAGCCTTGTTAGTTTATCCATGCTCTTTTCTTATGTAATTTTCGTTTATCAATTTCTCTAATTATTTTCGGTTTCCGGTTCGTGCACTCGCGCACCCTCTCCCTATTTTACTCTATCTCTCACTATCTCTCACATCTGTCTCTCTCTCATAAGCTATTTTGGTATTTTGCGCGTTAAGAAGTCATGTTTTGATGGACCGTGTTCAAAGGAAGAATATTTTCGGCGAGTGCAATGTATGTGGTGTGAAGTCACTCCATGAGTCTTATTATTCCGATAACCTTTTATCGAGATGTAGTACCTTATCGAGCGGCCCAATTTTATGTATGTTTATCTACATTGTGGTTACCATGTAACGGGAGTTCACATCGCAGGAAGTTCTTTATCGCGAAAGTATCAGACCCCGGATTACCTATCAGTTTAAATGCGACATCTTTCGTCGGGTGAGATATAGTATCTTGTGTTTCTATCGCATTTCATTGGACCGGTCGAGCCAGGTCTGAGTGTTTATGAGCACGAGTCGACTCCGTGAGTCTCAATGATTTTCCGTTTGCAGGCGGTTTTCCAGGTTTCCCGTTGGTTTCTGCTTCATCTTCTACTACCGTTTTAAGTAGGATTGGCTCAAGTCTACGGAAGAGTAGAGCAAGCCTACGGTGTAAAGAAGGTCTTCGAAAGAGTAGCGCAAGTTTACGGAGGATTCACGCAGGTCTACGGAAGAGTGGAGCAGGAATACGTTAGAGAGTCACTAGACCATACTGGGGGTCCGATTTACAATTGGATTCTCGAAAAACCGTGTACCTGCATAACCAGACAGCCGATATATCTACCTTACCGTCCAATTGGTCAAGTATTTCAGGAGAAGCGTATAAGGCTATGATTTTCTTTAGCAACGCCGCGCGTTTTGTAATTGCATAACAAGCTGTGTATTCCGTGTAGACTTTATCCTGCTCACTTGTTAGATGTTTAGGGACATCCGGTTCGACCTTTTTTCTTTCTCCCGCTATCGACGACGCAGATCACTGCGTATGAGTTGCTTTTATATACGTCGATCGATTGTTCCGGTATACGTAAAATTAGGCGCTATATTTTATCGCTTTCCTTGCTCACGCGATTCAGATATTTTAATGTCGAATTCCGTCACCTACCACTACGTAGGAGATATGCAGTGCTTTGTCAGAATAACTCAGGTCGTAAGAGTCTCTCAAGACTAGGGAGATATTCGCAGGTTGGTGGCAGTAATTTGTTTTTCCAATTAGCTATTCTCCTTGTCAGGACTTATTCAGGGAGTCGAAGTAGCCCGAGACGTTTGGCCCTAGTATGGATACTTCACGACAGTTCAAACAGATTGTGGTCGGCCTTTAATGGGAATTAGTTCTACTGCTCAGGTTCATAGCTGACTTAGCCGAGCCCCTTCGAGGTACGTCGCAATTTGGCGATTAGCATACTTCCAGGAAGACATAGACGAATCACAGTTTCAGAATTCCTATACACTTCGGTAACTACGGAGTAAGGCGATCAGTTCCTTGCCGCATTTATATGTTCATCTGAACTTTATATTTTTGCATATTAGCTCACGGATTACATTGGAAACTACAGATAACTGGGAGACAAATGCTTCGCTTTTTGTCACTTTTTCCGAGTTTACTCAAGCCCAGAGTAATGTAGTTTGAGGTTAATCTACTTCTCGTTTCCATGTGCAGATACTAGCAGAGTTGCTGTTATAACTGAGAGTCATTTCACACACAATACGGGTTAATGTCTGTCGGCAGTTTCTTCTCAACGCAAGGTTTTCGCTATATAGATAATCTGGTATAGCGGTGAACAACCTGTAATTATTAAACGCCTCAAGCATAGCCGTGACTAGTTATAGCCCCCGGCTTTGCGGGTTCTACCCTATACCACACAAAACCCAAACCAATAAACTGCACCCATGATAGTATATAATTCGTGTAGTCTTTTTAGAGCGTAAAGTTCTGATCAGGGAAAACGAATTCTCGGGGAACGCGATCCTAGAAATGTTTTCCCGAGAAAGTGAGGCGAAAGCTTAAAGGCGCATCGCCCTTAGTGAGAGGCAGGTCGCGACGCGACGACATCTTACGCGAGCAGCGGCGAGCGTCAACCATTCTATGTGTTGGTTTCCCCCCTCCCGCCCCACACACATATTATTACAAAGTGCGAGACATTGCCAGATATGCGATGATTTCCATCCTTACGGAGAAAAATCGAATTATTATGAAAATATTAAGTTTAAACCGTAAGTCGTTTATTTTCAGGAGGTGAGTTTTATTTTTCCTTCATCGTCGCCTGACTGGGCAGTCGGTGTCTATCTGAACAGGTTCGCAGCTCGACCCTTGTGCTTGTTTTCGGTAGCAGGAATACTTATGGGTTTTTTCTCAGTTTCGGGAGAGATATTTACAGGCTTTCAGGAAACCGAGATTCAGAGTTTAATAATGACATATCTTTACAGGAAAATTGTGGTTTGAGTTTGCAGCCTTTCAGAGCGCCTGATGGATCAATAGTTCAATCCACGGAAACACGGACGAAAGTGGTCCACCGAGCAATCAATGTGGAACGAGACGATTCCAGCGTTTACCATGCCCCCTAACATCGATGATGGTCTAGATATGGTAAAGTTCTTCCCATCAAGCGTTGTTCGAGTTTTGGACAAACTTCTTCGATAAAATACTTGACTAAAAAAGCGAATTAAAGTCTACCACAATTTGAAAAAATATTTGGTTCTAGATTATTTCGAAGATTAGACTATAAACATCACGGCCTAACGTAGCTGAGGTTTGACATGTTGTGGGACTGAATACAAAAGCGTGAACTCACGTAGACTGTCTCTTGAATAATTCGAAGAACCAGATGTGAGCTACGGAATAGGCTTAGGCTTAGGCTTGGGCGGGGCTGGGAGGAGTAAAAAATTGCGGAATTTGCCGTTTGAAGAGCTCGCGAGTCCGAGTTTGGCAAATTTTAAATTTTGCCGTACGGACACACCAAATTTGACAAAAAATCGTCAAAAATAACAAATTGTTCCGAGTTTGATCAGTTCGGTAAGAAAATTATGAAAAAAGTGATTGCAGAATTTGCCAAGCTCGCCTTTGTCTTTGGTCAATTCAGCACCATATGAGTGATTATTATCAATTTTCCACTGTCGCTACTCGTCGCATTTAACAAGTAGTCATCGATTGCCGAAACAACTTCCTTCCAGCTCAAACTTTTTTCTTAGCCTTCATCGGGAACCTTTCCTAATTTTTGCCCGGCCTTCTTAACCTCATTCTTCCCATCTTCCCAAATTACAGTCCCATCCTTCTTCTCTTCTTCTTCCCACTACGACCATCTTTGTCCACGTATAGGACCTTTCTCGGGAGAGTGTGTGCAACCGAGACAATTTGCGAAAAACTGCTCCCGGTCCCCCCATTCGTTTTCGCGAAATCAATAGACACAAAAATGTTCCGTAAAACAAATCTCCCCTTGTCGTTTATCCCCCTGTAAGTACACAATATCCTTTTCTCAGAAAAAAACCTTTGTTCTTCAATTTCGGAATCATCTTTTCTTCGTGTTAGTCCTGTGAAAGGCGGAGTACTGAAATATGGAAAATATTTTTAAAGGACTCCCTGATGAATATCTAGAAAGTTCAAAAAATTTTCCCTCATTTCATATTTCAGCTTGAAATCTTTCATTGTGCACTAATGAGATTTCGACTTCGAAGTTTGTTTGAAATGTGTTTTCAAGGTCAATTTTCGTCAATGTATTATTTTACTATCGAAAAACTAAAAAAATTTCAATGAGTAAAGTAAGTCAGTAAGCATTTGGTAAATAACAAAAATCTCGTAATTCTACACATAGCGTGTCGCGAAAATTCGAAATCTGATGGGTGCACAGAAATGCTTCAAAGTCAAATATAAAATAAGGGAAATTTTTGTGAATTTTGTCAGATATTCGGAATCAGGGGCAAATTTCATGTGAAGTCAATTAGAAACGTATTTATTTCGTGGTACTTTTCTAGTCTAAAACTAAAACTAAAGCTAAGCTAAAGTTAATTAAATTACCATGAATCTAATTTGTTTTGTTTTAAAGTTTCCGATTGCAAAAATTCCAAGATCTCAGTTTGCCGAAGTTTAAATAACGACTACTCTGGACTTTTCCCGAAAGAAATCGAACACCGGAGTATACTAATAAGATCCATCGACGGTACACAAAAGGATCATGAAAAAGGGGCACCGTGCGCATAATACCTTCTGGCTTTCCCCTTCCCCAACGAAAGATTTCCTTCTTATATTTGTTCGTTTCGTTCCTGCACACTGACTCCATCTCTTCTAACCCCCTCCTCAGTCTGAATACTCTCTCATCTCACAACGCTTCTGTCTACCTGCCTGCGTCCCCTCGGTACCATATACTAAGCTCTTCGTACCTGCCACTTACCAACAACTTGCCTCTTGGAGGTCTCTCTCTCTACCACATCACCTTGTTCTTCGACTTGTGGTTCTCTCTTATCGAAAAAGTGACTTTCCCGTGTCCTTCCGGGCCATTCACATTTTCCAATTTTATTCGAATTTTATGTGCCCACTGCTAGCTAGGTTCTATATTGAGTGCCGAATTAATTTTATTGATGGTCTAACTAAATAAAGCCACTGGCAACAATTTTTATAAAATTTGTTTGCATATTTATGTAACATTAGCGAAAGTTTTAAAATTCGTACTGTGTGAGACATCACTTTCGAAGTGTTCATTCTATTACGGGATCACAAGATTATGAGAATACTTATTGCGCAACATTCTTGACGCGCAATAACTAGTAGCGAAAACTACAGTAATTCTTCAAATGACTATTGTAGCGCTTGTGTCGATACTGGCTCGATTTTATTTAAATGATTTTTTTTCGAATAGTGACGTCGATATTCCATTTTGCGTTCTGTCATTTTCGTATTATCTATAATTTTATTCATTTCGAGAATCGAGCCCATAAATCGACACAAACACTACAGTAGCATTTAATACTGTTATTTTCGCTAAGATGCGCGTCAAGATTCATTTCCTTACGAAATACAAACTTCTTGGCGAAAATTTCAAAATTCAAATTGCCCGCTTAGTATTTAGCCCGATTAAAGTTTTCTGGAATTTCCTGCCAAATAAAAAGCTAGTTTAAATATTTAAAAAATAGCTTAGAATTCTTAGAATGCGTATTGCGCAGCTTATTAAAGTGACGCCCAAAGCATTTCATAGCGAAAACACAGTAATTCTTGAAATGACTACTGTAGCGATTTTGTCGATTTACGGGCTCGATTTTTGAAATAAATTTTTTAAAATCTTTTCGAATCAAGCCCTGAATAGACACAAGCTATACAGTAGTTATTCAAAGAGGTTTTGCGATCGAGGTATTTTGTGTGTCAAATAATTTATTCCCGTAAAACAAAATACCGCTCTAAAGATATAAAATTTACAACGCCTATTAAGCACCCCACTGAAACCCGCCGGAAAATCCAGAAAAATTATATAAATTTCACCTCTAAAAAATAACCTGGATAGTTGACCGCGTAATTCGACCTGTTTTATTCCCGATTGTCCGACTGACCACACCCCGATTCTCTCGAACTACCCGCGACAAGCTTAAGCATCTTTCTTTATTCCCACACTTTTCGTAAACTTCTGAGAGACAAAACAATAATATTTCTTTCTCAAATCAATATTGGCTATATTCTCCGCATCCCGTAGCCGGTCCCATCAACGTACTTCTAGAACTCCCACGAAATTTCAATTGCTCTATTGAAAAGGTCTCTCTTTTATATGACCCAGGCGCAAAATTTCGTGCAAAAATACAATCGACGGTTTTCTCGACGCGATAATTTTTGCTAAATTCCAAAAATGTGTGCGCCTTTAAGATTACTATTGTAAATAGCTTCAAACTTTAACCGATTTTAACAATTGAATTTTCTATGTTTTCCGTTTAATATATATTTATTTATTTAAAAATTAAGTTGAAATTGAGATAGGCTAGATGAAGATAAATTACATTACTCTTTAAAGGCGTACATGGCGTTTCGCGACCGGGTACAGTATTTTCGACTGCGATTTTGGTTTTTAAAAAACCTAACCAATAGAATTTCCAGCGCTCACACTCATTGGCCGTGGAAATTCAGCAGCAACCGTCCGACAGCTCTTTTTCGTCAAACGACGAATTCGACGATCGTCAGAACAAAAAGTGAGCAGTTTTGTATGAACAGCAGGTGTGATATGATTTTATTGTGAAATTTGGGACTACAAACCCGAAAAAACAGTACACCTTGTGTGATCTAGAAAAAAATAGAGCAATCGATAATTTTCGGGTAATTTTAAAGTTATTTTCAGCGAAATAAACAATATTTTTGAGCATTGGGTTTTCAGTCATTTTCGATTAAAAAATTCTTCAATGTTGAGCTGAAACTATCGATTTTTACTAGAAAATTGATATTTCTAGCGCAACCACAATTTTAATGTTTAAATTGCTTTGAAACCTCATAACATCTCCCGCACCTCCAGTTTTTGAGTTTTCCGAATATCGGAAACTCAACAGAATCTCATTTTCCTACCGAAATCTATTAGTTTATAATAAATTTGATCGTTTTCTGCTTAAAATTCCCTGAAACTTCTGAAAAAAAACCGATTAATCAGCTAATTCGCTTAAAACTAATTTCGTGCCGGGATGACCACGGCCTCGGGTTTTAAATCGTATGCGCTTTTTGTTTTGTACCATGTTTATTATAGTTTTTAAAGTAAAAAATGAAATTTTCAGCAAGTTTTGGCGTCAAAGAAATGTATCGAACGCATAAATTGAACGAATACTGGAGGCTTGATTTCTGGTATAGCGAATGGTATTCTAAGTGAGTTTTATCCGATAATGGGAATCGACGAAAAACCAGAAATAAACAGTTAATTTCCAGAAATGAGCAACGGGAACAGCTGCAATCACCATCACCAATTCCCGATCAGCATTCCAATTTCGTGCTCGTCACACTCAATTCAATCACGATCACGAATGAGGACACTCTGAACGCGAATAGGGATCTCCTGTCTCGTGCGCCTGCAACGACGTAATTGTCGCCAGAACCGTGTAACCGTCGTTTATTCGCGTGGAAGGCCGGCCGGGATAATGTTTTTCTAAAAGACCATGTCAGGATATTGGGAAATACAACGGTATGAAAATCGGCTTTTCAGCGATAAAAATTGGAATTTTCAGGTCAACCCAGCGTGGTATCCCGTAATGCTAATCAGGAGGAGCGTATGGTTCATGCACATTGTGTAGTGAGAATAAAATTGGTTTTTCTGACCTTTCTATGAATAACCCCGATTCCCATGAAAATATAAGGATGTTTTCAGCAGAAACTCCAGGCAAATTGAGTTTTTGATGCGAATAATGGATTAAAAAGGATAACAAAAAAATCCATGAAAATTATTTTTTACATCAAAACTCCATAAAAATCGGATTTTTGAGCGGATAGATTACTTTGCCAGAAATTGCATTTAGCAAAAAACAATTCTTGCGCGCAATTGCGAACAAAAAATTCAGAACAATGAAACATAACAAAGTTAAAAAAATTATTTATTTAAATACTTTTTTGAGCTGAAAATAAAAAAATTGCCTCAGATTTTGTGGCCAAAAATTCAAGAATATTGCATGAAAATTAGTTTTTGTTTGCAGACGAAAGCAAAAATTAATTCTTTTTCTCGCTTAAAACTGGGTTGATAAAATGGTGTTTAACACAAAAATCCACAAAAAATTGATTTTTAGGCCACAAAATCTATGAACATTCTGATATTCTGGAAAAAAATTAAGAAAATTCATATTGATTTGCCATTTTGTTCAAAAACTTTTTTCAAAAGCATTTCATCAGTGGGAAAAATTTGATATTTCAACAAAAAAATTATTAAATTTTAGAGCTAGCCTACGGCCATGGAATTGTAAGACAGACATGAGAGCTAGCGGATGTGACGTGGCTCCGGGAGCAGCTTCAACAACCTCCAGCACATCATCACATCATTCAACTGCAACAAACCATCAGCCATGGTTTCATTCAAGATTAGCAGAGAACTGAAAAGTAACATAGAAAATGTTGGAAAATCTGGGAAAATGTGTCATTATTCGGTTTTGTCGTCAGGTTTCCAATTTTATGAAAAAAACGTCACTAAAAACGACATAATTCTTACGGAAACATCTGAAATTGTTTGCATGAAAAAAGTCGCGATTTTCTAGAAAATTTTAAAATGTAATAGAAAAATGTTGAAAATAGATTTTTTCTGAATTTTTTGAATTTCATTAGATAATAGAGACAACATCATGTTTTGGAGTCAACTTTTTCGCCTGAAACGCTGGAAAAGGCAGAATAATGGTTAGGGTTTTTAGTGGTATCGAAAATAAAAATGTATTTTTTAAAAGAACGAGAATTTTTTTTTCGTCGAACGTTAGTTCCAACAATAATTACTTACAAAACATTTTTTGTTGGAACGTCTTTTTTTTCTGAAGTTTTCTTAGATTTTGATAACTTTCTTAATTTCAATTCAAATCGGCAAAATTGTACGCGTCTTTTGACTGTTCCCACATCTTTGTAACGAATACGGGAAAAAATATTTCAAAAAGGCACTTTTTTCAAGTGTTTTCGCCTTATAAAAGATTGCCTTCCGGCAAATTGGGATATCCTACATACGGCAAATCGGCGAACTGACAATTTGCCGGAATCGAAAGATTCCGGCAACCGACAACCTTCCGATTTGCCGGTGTCAGAAACTTGAAAAGTGTAGAAAAATAATTGGACGTCACAACTAAATAATAATTCATGTCATTTCTTAATGTATTTTAATACAGTTTTGACGTCATTTTTCTCCATTTTTCATTCTTCCGGCGCACTTGAATAACCCTGTATACCACTTAAAAATCATGTTTAATTTACAAATTTGTAAACTCCCGATTACCTGCATACCGGAGGAACCTTCCTAGTACGTGAATCCACAAATTTCCCCGGCGTCTTCATCACTATGTATGTCTTTTCACGGAAAAGTCGAACACTATCAGTGCATCGAACAGACGGCGGTCAGCGCAATTGACCTGTGACCAGGAAGAACATGGTACTTTTCCAATTTGACACAGTTGGTCTCGGTGAGTCATTTCGGGGCTGTAGAGACAGGAAAAGGGGGAGGAATGGGTGAACCGGTATTCGTTAGACTGAGACAGGTGAAGATAACAGTCATGATTTTATATTGTGAAGAGTTGTATTATAAAGGTTGGTTGACTAGATTTGATTATTTGGGCGAAAGAGAAAGTGAATGAGGGGAAAATTGTTAAAATTCGGATTTAAGTATGAAAACTCACAAAAATGTTATATAAATTTATATTTTGGATATAACTAATTAAAGATTTTATATAGCAAGACTTTAAATAATATGAATATAATAATCTAATATATCAATCTCCTCATTTAATGGCTAGTTGTAATGTCCAATTTTCCAGCACTTACCTACAAACGTGACGCGGACGGTCTCTGCCATCGCCTCGTGGTAACTGCGATTATTTGTGAAACAGCGACATTTTCATCAATCGGATCATCGTCATTTGGTTCATCGTCGACAGTTGATGTGGCATATCGTACATCAGTATTTCGACACGCGGGTTAGATATTTCATCGAACGATATATGTTGGTGACACAATTGCACGGAGACGCCAATGGAGATGTTCGATTGGGAACTTATAAGAATCGAAAAGTCGCGCTAAAAGTGTCGAAAATGCATGGAAATGGAATGTTGGACTCATTGCTGGATGAAGCCATATGGTGTAAGTTATCCAATTATTGAGAAGAAAATAATTTTGGCAAAGCCCAAAACAATGCGTGTTGAACAATGTCATGTTAAAAATATATTTATGTTTCAAAAATGTATTTCAATTTAGGTGTTGCTTTTAATTTGGATCTCAATAATAACAACGTTTTCCAAGTTTTTAGTTATGAGTACCCCGAAATCTGAAAAATATTTTCAGTTGACTTCCAAATTCCCTGATTCCGAAAGTCTAAGTGAAAGATTCGAAACCTGATGGGCTGAGCACAAATTATTTGTACAATTTAAACACTTTTTAATTAAGATAAATTCCCCAATTTTTTTGAAAATATTCCATTAATTCCTATTTTATGTTAATAATTGATTCAGTTTACAAAGCTTAGTTTCATAATTTTCAATTTTCCTGATTGATGAGATAACTAATGGCAGCAAATAAATCTGAAAAATCCCGAATTTTGCAGAGGTCTGTCGCTGAACATCCAAATCTAGGGACGCTTGTCGTTGTTGTACTGATGATGAGTGAATGTCGACATGATAACTGAATATATGGCAAATAGTTTTAATCGATTTACTCCGATCTCGAGGAAGGCATGCGTTGGAGAATCGGAGGCAGTTAATGTATGTTCGATGTAAGAAAAAGTTGACAAATAAAAAAATTGGAATTTCACATTCGCCAATTAGATTGTTCAAAAATTGTTGACATTTCTGCATTTTTATAACCGAAAAATCGACATTTCATTCCGCCTGAGTAATAGTAACTCACCACGAAAAGGGTTACTGTAGCAGTCTTTTAGCTGTCTCTGGTTTAGTAATTTACGATTTGCCGGTCGTCTGAAACCCGATTTTTTCTAGATTTTAACAATTTTCTAGTATGCTGTTGGCAATTCATTCCAAAAACATTTTAATGTTGCCGCTAAATTTTTGTGCTCCGTTTGTCGAAAAGCCGACTTTTTAAAAACACTGCAAAATTTCTCTCTAAGTTTTTTAAAAAATGGTTGCCCTTGAAATCAATGCAGTGTTTATATTTTATTTTGGATTTTTCGAACAAAAATTTTGTTCGTCTATCCGAAACACCAAAAAATCCACTTACCATTTTTCGAAGCGAATTTTTTTTTTCCAAACAACAAACCTGATTTCAAGGGTAGAAACATTTTTTAAAAAAGTTGAAAAAAATATTGTAAAATCGGTTTTAGTTTTTAAAAAAAGTCGTTTAAATTTGTTGCACAATTAAAAAAAAATTTAGAGAAAAATCTTGGAAGGCTTCACGCACACAGCTGAAAATGCTAATACAGTACAGCTTTTCGTGGTTGGACCCAGCCACCGTGGTTACTCTACCTCCGGCAAAGTGGAAAATTCGATTTTTTTGTTAGAAAATTTGAAAATGTCAAAGACCTGTGAAATGTTTCAATTTTTTGTGCCAGCTGTTCTTGAAATCCAAATTATTCGACTTTTTTTCCATTTTCAGGGATACTTGCCAAGGAATTTATCTGGAATCAAAACAGATTGTTCATCGAGTGGCCGCTCGAAATGTCCTCGACGATGATTTAGTAGCGTAAGTTTCCGTTTTTGGATTAGCGAAAAAAGCACTAACAGCCAGTCACATGATTCGGCTTCTGGCAAATTTCCGGACTGATTAAATGGACGGCACCTGAAGCGCTTAGACATAATGTAAGTTTGGTTGAAAAATTGATAAAATTGAGAAATTTTTACAGAATTTATTCTTTCAAAATTAACAATTTCATAAAAAGAAAGAAAATCATTTCAATTTAAGGAATTTCGTATTAAATTTCTAATTTAAAAAAATGTCGATATTTTTTAAAATTAACAAAATTTGAAAACAGAAATCCGTAATTCCGCCGAAAAATGCCTCAAAAATCTGCACTTTGAATTTTTGCCCAAATTTCTAGAATTTTTCCTTACTTCATTTTCTTTCATAGCTTGAATATCAAAAGGAAAATCTTGAAAAAAAATCCCAGAAAAATAAAAAACAACCAAAATCGATTGATTTCAAAAGTTTCTTTTTTAAAAATTGGTTTTTTGTCATTTTTTTCTGATAAATGGAATAGCTTGAAACTAGAATTTGAAAGTATCCAAATTTTCTAATAGATCGATGAAAAATGACTCAAAAACTCCAAAAAATATTGAATTTATCTCTTAAATTTTTCAAAAATGGAATTTTTTTCACGTAAAAAATAGAATTTTTTTTCCCAAATTTTTTTTAGCAACACCACAAAATCCGATGTTTGGTCATTCGGCATTCTTCTTTGGGAAAAATTTTTTCATTCGGACGAATACCGTACCCAAGAATTGTGAGTGACAACATTGCTTAATTAAAAAAATTTCTCGTGTTTTTTCATATTATTCCTCGCTAGCTGGATTGTTTTTATTTCTGTTTGGTTGGGATCATTTCTTTAAAGGCTCCACGGAAAGGGAATCTGCCTGCGAGAATGAGATCTACGAAAATGAGCGACAATGCTAGGATGAAACGTGCGTTGTTTAGCAAGTTTTTGATACTTTTCAAAAATACTAGACTTTTCAACCTTTTTCGTAGATCCTCTTCTCGTAGTTTTTGGTGGGTCCCCTTCCTATATTTTTGGCTTGGCCGAGTTTTCTCCCGGCCACGATCATCACTATTTTATTGATTTTTGTCATGATTTTCAGGGAGCCGATGGTCGATCGGTATGTGTATATTGCATATATTCGTTAGGTTCTATTTTTTACCAATTCTATCCAATTCTATTATACAATACATCTCACTATATTTTCCCCTGCCTGAAATTTTTGAAAAAAAATGAGGCAATTTTAACTTAAAGCTTTTTCCAAAATTTTCCAACAAAAAAAGTTTTTTATTTTTCAATCGCTCGAATTCTGAAAATGAAAAATGATGATAGAAATTGTTTTAAGAAAATGATTTTTTTGGTAGCAAAACGAATTTAATTTTTAATCGAAATACAACTTTTTTTTCAAAAACACCTTATTCGAGACAATAATATTTCTTTTCTTTTCAAAATTGAACATATTCTGGAAAATTGAATAATTAAAAGCATCAAGATTAAATATTCGAAAAAAAGAGAAGTATAGATTTATTGGCTTATTTGGAAAAAAGAAATGAAAAAAATGCAATAATCGAGTCTTTATTTTGGTTTTGTTTCCGACGATGTCCTTCTCGTATATAGTATTTTCCTACCACGAAAATCGCCGTGCAGGGTCTTTAAATTCGGCCGACCACGTCTCGCCTAAGTCCAGTCCCCCACATGTCAAATAAAATTTTTTTCGCAACATCCTGAATTTTGAAATCTTTTTCCAAAGAAAAAAAGTACCGTTTTTTATTTAATTTTAGAAGCTTGAGAAAATGCTTGGAAAAAAGTATTATTTTTTCTAATTTTGAACTTTTTAAAAAAATTATTATATCTTGATTTTCAAAATTTTCCATATTCGATGTTAAAAATTATAAACATTTTTCAGAAAGTAATACCGAAATTTTTTTAGAAAAAAGTCAAATTTGGAGCGAACATTATGTTTTTCAACAATTTGTCAACAATTTTTGTTCACCGCGATTTTTTTTTTGGATCCAAAAAAATCTTTGTTTGTGTGATTTCCGACGGCACCCAACTCCCCAGAATTTACCGCAAAAACTCTATTTTTTTCTCTGCTACCTCTTCCCTATCTTCTAATTAATGTTTTTTCACTATTCGTTTTTATTATTTTTTCCTTTCAGAGCTCAGTTAGAGCCCAAAACTAACCATCAGAAACAAAAAAAACAACTTTCTTTTCTTTTCGAATTAATTTTTTCAGCCTAGGTTCAAGGCGTTGTGAGATATTGAGTAGGTATCGAATGGAAGCACCTGAAGGGTACCGGAAATTTTCAAGGTTATGAATGAAACATGGGCTCTTTCGGCACAAGATCGACCGTACTTTAGGACAGGCAGATTTTTTAAGGGTTTTATAGAATTTTAAGAACGATTTCAAAATCCGAAAAAAAAACCTACAATTATGGTAATTTTTGAGAAAATCTACAATTTTTTTTCGAAAACCTGACAGAAAGAAGAAAGATAATTTGAAAAATGCCCTAAATTGACCAAAACTATGGAATTTTTACCAAAATTTCAGAGGGGTTTTTCAGATTTTACCAGAGTTTCTGCCTTATAAATTAAAAATTTCAAAGGGAAATATTTTTTTAAAATCAGCATTTTTAGCAATTTTTGTGATAATTGTTTATGCCAAAAATGGTGCGAATCTCATGTTTGAAGATTTAAAATTCAGAAAAATCTAAATTTTGGGCAATTTCAATAAAATGGAAAGATTCTGAAAATAATAAATTTTTCGAAATCATGAAAAAAATTTTACAATTTTTGCGAAAAGAATTGTGAAAATTAGAAATTTTATTATTAAAAATATTCTCATGATAAAAACAAAACATTTCAAAAATCCGCCGAAAATGGCTTAAAAATCTAAAGTAAGAAAAGATTTTGCATTAAATTTTATTGATTAGTATTTGCCAAAAAAACCCGAAAATTCACTCTAAAATTACAAAAATTTCAATTTTCTTAAGCTGCGTCCACAAAATGGCTTTAAAAATCATTTTCATGTACAATGTCAAAATTTTAAAACAAGTGAAATTTTGTTCAAAAGTTACCATAATAAAGGTTTTATGCTTTCCGGTCATTTTTTTTAATTTTGGCACACTAACCGAAAAAAAAATTGCTCCGCATTTTTACCCTGAAATATGCGAAAATGTTTGCATTTTTTGAAAATGCCACTTAAATTTTTTATATTTTCAGGTCGTGCCGATTGACAACCATCCGAAATTACAGTATGACATCGGCGCACATCTCGAAACGTTTTCCAGAATCCATATCCACCGAATTTTCTAGTCCATATGAGGTTTCTGTTTTTTTTTCGATGTTTTTTACACAAATTTAGTCATATTTTATAGTAATTTCTCCCACACATTTTTAGGCATCGTTATTATATATTTTCTAATCCGCTGCCACGCATTTCGGATAGAGATCCTGGAATTTAAAGGCACAGCGGTGTTTTTGGATGGGTCCCACCTCGATAAAATTTTTGCCATGCGCTCCTTTGAAATTTTGTTTTCGATATTCCTAAAAATCACAAAAAACATTGTTTTTTCTAAATTCGAGAAGTTTTAGCCTTTCTTTCGACTAAAAGTCGATTTTTTTACGTTGGTTTAAATTTTTCTCGATTTGAAAAAAATTTCAATTTTCAGTGAATCAAAGAAAAAACATCAGGGAGCAAAACTTCTATTCGAAAGAACAATATTTTAAAATTGTATTTTCCGATATAATTTTCACTGTTGGGTCTCACCACGAAAATCGACATGCACCTTTATATTTCCTTGCCAACACCTCTCCGAACGGCCGATACCAAATACCTACGGGTTCTTCAATTTTCCTCTGCATCATCGATGCCGTTTTTAAAAATTTTTATCGAATATATTTTCACGTTTAAAATTATTAATTTGTAACGCCAATTTCAAGAAAAAAGGCTCAAAACTCCGCCATTGGGATAATTTTTGCAGCGACGGAAAATGCAATAAATTTTATATTAGTTTTCACCGATTTTTAACAGACTATTTTTAGAACTTTTAGTCATTTTGTATGTGTGTGTTGCTAGCGTTTATCGGCAAGAAATTATTGTTTTTTCTTAATTTTTAATAAGGGACATTTTTTAAAGAGATTTTCAGAAAATCGGTAAAGATTTAAGATGCTCTGAATATGTCCAACTTCACAAGCTTCGTAGATTACGCGGATAAGGTGTTGAATGAGTTGAATGTGCAAGTGCGCCCTATGGATAAATGGAGCAGCGTGGCAATTCGAAAATTCAAGAAATTTAAATAAAAACGTATTACTCGAAAGTTCACAGAGTTTTTCACCAAAAAATTGAAAATTCGCTGAAAAAGTCGCGGGACATTTTGATTTTTCGGGAAGATTAGAATTGACTGAAAAAACCGCGTCTTTATTCGAGAAATTTTAGAAAGGCGGAAAATTCCAGATTTCTTTATTTAAAAAAAAACATGAATAAAAAATTCTGAGAAATCATGAAAATTGATTGAAAAGTTTCAATTTTAGGCTAAAATTTTTTTGCGAAAAATTCATTTAGTTTATGTTGGTAAAGTTCCGATTTTTCTGCAAGACGAATTTGAATTTCTTTCTGAACAAGTGCGTTTTTTTTCAAAAGTTTTTAAAATCGGAAATTTTTCGCCTCGAAACTGAACCGAAAAATTCGAAAAATGAAGCGCGGGCAATTCGTCTTGAATTTTGGCATTGAAAATATATGAAAAATTCAAAAATTGGAAAAGCTCAAAGTTTTTCACAAAATAGTCGATGTATTTTCTCATTTTTCAATGTAAAAACCGATAGTTACCGCCGCACGCTGGGTCGCAGCAACAATGCAGCCAGACAACAATACCGCCGTCACCGTTGAACGTAATAAAAAACGGCCAATTCCACTGTTAAATCCAAGTGAGTTTAATCGATTTTTCTGTAGAAAAATCTGAATGTAAATTTTGAGCTGAATTTTCAGACGAAATCAGCAGCTCTTCGTGCTATGACGTCTTTCCATGCAATCCGGAGAATCTCAGCAGGGACATGTTATGTACAAGAGTTCGTCGATTCTATCCTGCCGTTGCTGAAAGAGGAAACTCAAAATGAAAAAAGAACTATAGTACTATACATTCGAAAAAAAATTTTCAGTTTACAGGCGCATCTTTAAATATGCATTATTATTCATTAGTGTCGACCCAGAAAGCGCATGCAAATTTTGAACTAAACTGGAATAAAAATTTTATTACACATTCGTGTAAGAATATTCAGTTTAAAGGCGCGTGCTAGTTTTAAGCGTACTTCAAAAATCAAAAAAATATATATATCTATTCGTGAAAACATGTTCTTTTTAGAAGCTCTTTAAAAGTTTAAAAATGATTATTATACGGTTTCTAAAAATTTCCAAAAATCAGGTCAAATGCACTTAGAAGATTGGAAAATATGAAATCTTTATACATGCCTGAAAAAATACGGCATGGTCCAAAAGTCGACAAATCGGTCCAATATTTTCTATTTTTTCAGAGAAATCTTGCGCCAAGGTCGAAATTTTTCGACGATTTCTACGACGTTCCGTGCGATCGCCAGAATTGAGGAGGGAGACCATTGTGAAAGTTGAAAGCAAATATTTCTTCAAAAAATTATTATATTAAATTTACACATACACATTCGTGAAAAGATTTAGTGCTGCCGGCAGGTGAAAATAATGAGATGAAAAATATATACAGAAAAAGGAAAATTTGAAAAATATTTTTTGGCGATAATTAGAATATTACCCGCAAACAAAATTCAAATGACATTTCTTCAGTTTTTGAAAATCTAAACACAATTTCAAAATGTCATTATTGGTGATTCGTGAAAAAACTCAGTTTAAAGGCTCATTTCATATTCAATATAAATGAGAATTATTAAACATCTTAAAGACATAAAGTTTACAATATAAATGAAATCTAAGAAGAAAAATTATACATTAAAGTTGGGAACAAAATTTTGTATTTGAGTAGGACGCTTGACATCAATTTAGTGATATAAAATTTTGAAACCAAGAATTTTCGAAAAAAAATCACGTATACCTAAAAATTTGTAGTTGTTTTTTTAAAGTTAGTACAGAAACTATTTTCTCTAAAATTCAAAAATATTCCAGGTAACATTGGAACACAGGACAATTTTCAACCCTCGAGACAAGCCTATCAATCCAATGGAAACACTATCAATAATTCCGAATATTAAAAGATGTCAGAGTTGTTACAATTGACTTGAGAAGATCTCAAAATGAATATATTGGCCAATCAAATACTCTACCTCTCGAAAAGGGGACCAATCGAAAAGATACTCAAGTTGGACCTGCTATGGAGGACCGCGATGTGAAGGCGAAAAACCGTAGGCATTGGATAGCTAATTAGTATTGGGGGTTGGGAGGGGAGGGAGGAAAGTTCGAGAAAATCGGAATATCTTATGCACTAAATATTACTTAGGCCGTTTGATTAATAAATCGACACATCAAGTAAATAAATTCTGAAACAAATTAAAAAAACGTTTCGATTGATATATGTGTATCATTTTCAAAAGATGACATAAATTGGCAAACAAGAAATTTTTTATTCAATAAAAATATACTACGGGAGCCTAAACTTTTGGAGAGTGCGTATTGCACAACATATTGGACCAGATATCTCGAAGCGAAAACTACAGTAATTCCATTTAAATGACTGGTGTCGATTTACGGGCTCTTTTTTCATTTCTCCGGATTATTTTCTCTTTTTTGCTAAATTTTAATATTCTATCTATAACTAAAAAATTAATTCATTTCGAAAATCTAGCCCGAAAATGGACACAAGCGCTACAGTAGTCATTTAAAGGATTACTGTAATTTCGCTACGCGATACTTTGTGCGTCAATATATATTGTGCATCCAGTTACGCATTTTCAGAATTTTGTATTCTCATAAAATTTTCGAAAAAGTAAATCTTTTAAAAAACTTTTTATTAAATGAATAAAAATTTTTCCCCTTGGAGAATCGGATAAAAATAATTTATTTAAGTTTTGAAATTTTAATATTTTGAAAAAGAAACATTTGACGTATTGAAGAAAAAGATGAACCTTCTTTTGTAAATATGGTTTTTACAAAATTCCAATCGTCCAATATACAGACTCATCATTTTCCAGCAGCATTTAATAGCTACGAAGCATGGCGCGTTCGGAACTCGAAAGGTGCCAGCAGAAGACGGATTCGACGTCTGTCTGGACAATTGCGTAGCACTTAACAAAGAAGGCTTCAACTATGCGGCTCAGCGGGGTGCGATTTTTGGAAAGTCAAAAAACTGGATTTCCGATTAAAAATATGTATAGTGTATGTATTTTTCAAATTTCCAGCTACCCTGTGTTACGTAGTAGTGAGCAACTTCTTGGATCGTGTGGACATTGAACGACAACTACAACACCACAAACAGGGACGATTTCCGATTTGGGTGTGGTCTCGGGCGAACGGACACTCGACGTTATTCGTTTCGGCGCATCACGAGAACTATATCGGATGCCGGGGATTTCGGCGAAGTTAGTACATTATATTTTAAGTATGATTTAAAATGTTATTTTCTTACCCAGCAGCGTTTGCAAGAAAGTATCACCCGTTGCCATCTGAATAAAGAGAAGCCGCATGTTCTAAACTTGGACGTCGATTTTGTGTCGAATGTTGGAAAAGCTTTTGATAATCTCCCATAGCTTAGTGCAATTGGTGAGGGAGAGCATTTCATATTTCAAAAAAAAGTTATTCGCCGTATTTTCAGCTCTTTTATTTTCCATAATTTTACATATACTATGCAATTTCCCAGACTCCTACGAGCAATACGTTACACACAGGTGCAAAACGGTTGGAATACGAAACTCCTATCGGGAGAACCGGATCGGGCTACATCTCGTCAACCTCTGCAGGATCACAACCTATCAGACGATTCAATGGATAGTTGATAGAGATCGATCGGTTAACAGGGTGTACTATCAATTTAGTATTCAGAGAGAGGGAGAGAGCGATTTTCATAAATATTTACATACGAGTTAGTCATTTACCACAATCGACTGATCAGAATCTGATACGTGGCCGTTTTGAGACCCTCCGCCAGTACTTTAGGAACTTGCACCGAACTTGCTGCTTGATCCTCCCCCTCCAGAGGATCTTCTCCAGATGGGATACAACTTTTGATGAAGCTGATCATCGGATCCTCCTGTCATCCGAACTAGATTCAACTGTCTGAGAAGAATACAACCAGTGTCTGCAATCACCGGGTTCCCTTTTGCTCGTCGAGTACTCAAATTGTGTCGGCATATGAATTTGTCCAACGTGGGAAGCCTGAATGATAAAGGGGGACTAGCGTCGAATAGTTATTTTTTATGTTTTTCATATACTCGTTTGCATTAAAGTAACGGCTCTCCTACCTTGAAATCCGAGTTCGGACTGATCTTTTCTCCGTTTCACCGAGATGATTCTTCTGGTGACTCGTTATTTCTCCTTACGCTGATCGTGAACCCATTTAATCAATTCCTGATCAACGTCGTAATACTTTAAAGGTCTTCCACCTCGACCTGTCGAAAGTCGCTTTGTTGCAGTTGAGCCTTTATCTTTCTGAAATTATTTGCCAAAAGGCACAAGTCGAAAATTTTTGGTAACAAAATGAAAATTTGAAATCGAACAGAGAATGTATCTGGGTTATGCCCAGTATTTCAAAATATAGGAATAGTAGAAATGACTTCTTTTGATAGGATAAATTATAAGCCTAGAAAAAATCATAGTATTTGAATTAAAAGGTCCACAAAAGGTTCTATTGATTCGGCAGGGCTTGCATGTAGTAGCGAAACCTGCCTTTAAGGCGACCGCCGCTTGCCTCTCGGTTACGCCTTACGTTGTGCTAAAACATAATTCAATCTTTTTTTTTTTAATTTCTATTCTGATTTTCAACAAATTGAGAGAAATGAGAAAATTAGAAATTTGTAAATTCACATAGGCGGGTTTCAAGCAGGACCCTGTCACCGCGCATGCCTAACATGACAGTCATAGCCCTGGACTCTTTCCTTTTTGAACACGAAAATATGTCCGAAGTGGCAAAACTTACAACTGCTTATGCCTCGATTTCAGCTTTGTGGGCAATGATCCATTGTTGAATGTTTTGACCTATTCACATTCAAATCCTTTGCTGCTTCGATAAATTCTTATGTTCGTTCAAGGGCATAATTTATGGCCTGCTCAAAATTCAAGTCATACGTTCTTTTTCGAGTTTTTACATGCACTGCTGTAGGGATTTCGCTAATTGGTTTTCTCTGAAAAATAAGTATAACAAGCAAAGTCTTAACTAGTCAGCAAGTTATTGGAAATAACGAGAGAGAAGCTAACGAAGGGAAGACCAATGGAGACAGCAAATTGGCTGTTACACACACAGAGAGACATGGCTAATAGAGTGTGCCTATTAGAGGGTCGAGGAATTGCAGTGAGACGAATTTACTGGGCATGAATGTAAAGGGGGTGCAAGGCTAATAGGAGGAGAAAAGTACAACTACAAAAGCATTATTATATAAAAAGCTAGGAATACCTGTATGGGCACCCCAAGATTTGTATGTAAGTAGTTATGTAAATGACTTTTTGGAATTGAAAGGAAAATACCAAAAATGGAAAAAACCTCCGGTCAATCATAAAAAAATTTTGAAAGAAGTTCGATCTAGGCTACGGTTTACAGTTTCCCTGATTTCTACTAAAATGCATTAATCTTGAGTTTATCTCTAACAAAGTGATGGTACTTTTGAATGGTTATAACACAGGTTGCAGAAGACGAAGGATCAGCTATGTCGATTATTGTGGCCCTCAGAGCCTCACGCAAATGTGGTGTGCTCCAAATTTTACAGAACAACTACGAGTGCAAAGAGTTTATTAGAAATGTTTTTTCTGTACTAAAAATGGGGTTTAAAAAACGAATTTTGGTTGATTTAGTTCTCTCCTTGTATAAATTTCGAAAATTTTCCGAAATTTTTTTTTCAATATAAACAATGTCTTCAACAACTCATCGAAAAAATGTGGATTTCGCGCCCTTGGCCACCCATTTGGTGAACGGCTACTCAGAAGAACCGACGATATCCATCGAGACGTGGGAAACCACAGAATAGAATGAGAACTGACGTCATGCCGATGTGGTTGATCTTATTGGATTGTGTTTCACAGATAAATATATACATTTGAGTAGGTTTGGTGAAAAAAATGTTTTTCCTCGCAAAAAAATGTTTTCAAAATTTGAATTTCCCACCCAAAATTTTTCTCAAAAATTTTTTTAAAAATTAATTTTAAAATTATCTGTTTTCTCAAAAAATTTGAATCTCCCGGATTTAAAACTTCCAAAAATTCGTCTATCAATAAATGTTATATTAGATAGTTTTCGACGAATCATAAAAATTAGTTTCTAACGCACTTTTCAAATAATTTTTTTAAAAAATAATTTTAAAAACAATTAATTTTCTTCATTCAATTTCCAGATTCACATTCTCTCCACAAAACCGTTCTCATTGCACTATGGGATCTATAATTAACTGGAATGGTCCCATCAATGGCTTGTAATAATCTGGAACAGCAATTACTCGCAAAAGTCGGCGGTGGACCATTCCCATTGGATCGATATTTTGAGAAAAGATACCTACTCGAAATGGAAATATTTGGCACGACGCAGTGCTTTTTATGGAATCAATTACGAAAAGTTGGTGCTTTTCAAGAAAAAAATCCATTTATATCGATTGTTTTTTTCTTATTGATTTCAGCTACTTTTTCACCTCCGTCAGCAATATTTTGTTGCAACATTTTGGACGTGGCCGCGAAAAAAAAATTGGTGGCCGAGTTGTCTTTTTTTTCACTGCCATTAATTGAGAGGAAAATCTCAGGAATTGAAAATTTTTTCGAAAGTATACAATGTTGACCGAGAAAATATAGGGGGCCGTGGAATTTCTCTTTCTTCTCTGCCACGTTATTTTAGTAAACAATTAGAATAAAAAACACAGAATGTTGTTCAAATTGAAAAAGTCTCTAAAACAAGAAAAAATTGATGGCCGAGTTTTATTTCCATTTTGCGCGGCCACGTGACAAGCAGTGATTTCTCAAACGTTTTCAGGAAAAAAAAACAGGCGGAATTCAGATAATCCTACGAAAACTATTTGTTTCTGGATACAAAAGTCAAAACTTCAAAATCGGTGGTCGAGTGTTCTCTTTTTTTGCGGCCTTATCACGATCCAGAACCAGTGTGTGCTCACTCGAAATTCCTTCAATGTGAATTTATTCGGCCAACGTCGAGACGTTTTTGCGATATTCAACTGTGGTCCGCGTCATCGATGGATTCCTCCGGCAAACGGGAAAAATTCGGGAAAACTCGGCGAAGTAGAACTCTCGCTGGACGAGAAAATGATCGAAATGCCCTTGGAAAAAATGGAACTGTTCCGAGTGGAAAATGTATCATTTGGACCTACCGGAAGAGGTGACCAAACTTTTGGATTTATAGGCTTTCGAAACATATCTTACTCTCAATTCTTAAATCTTTAGTATTCATCTTCATATCCTTAGTCGATTCCGGAGATTTCCCCAATAATTTAAATGATTTTGATATGATCCGGCCGGATGATTTCGGCGCAATGTCCATGAATTCCTCCATCAACTAACTCACCATCGTTCGTTAATACGGTAGGGATACTTATTAGCTCGGAAAATAAATAACGACACATTTTGTCTCGAATTTATTATAGGTGACTTAGTAATAGACATTTAGTGTCTAGGCACGCATAAAAATTAGATCTTTTTCATCGTTCCGATACTTTCACACAAAAGTACGTTTTTTTTCGCAACGTTGTCAATTGAACAATCAATAGGTCGGCAAATAATTGTTGGAGTGTTTTGTCACACGATATTTATCAAATTTATATGTGACTCCTGGTAGAAATTTGTTATGGTCGGCAATAAGTACTGAGTCATAAATTCATATAACTTGTTGTTTGCTTATCGATTGTTTTTAATTGCCGGAGTTCATGTTATTCACTATGGGCTTTCATCTTAGTCAACATTTGGTTAAAAACTCGAATCCAAGTAGAAACAACTTTTTCAAGGTTTACGCCGTGCTTCTTTTTTCTCTTATTTTCTGCACTACATTGATATTTATGTAGGGATCCAGGCCGAGTGTCGGTATTTCGATTTTTGTATAAAATCGAAATTTTTTTTTTGATTTTTCGATTTTCCCTGAAAACACACAATTGAAAAATGTCACCCTTGGTACGGATATTGCTATCTATTATACAGTGTGAGAATCCAATAAAATTATATTTTATTTTTGCAGCCAGTTCGTTACAACACGACAACAGATTGAAATCAATATTCGATCATTCGACACTTGAGAAACGAAATCGTCGAGCAGCTGCCAGAATTGGCCCCCGCCAGTTATTCAAACCAAATGGCAAATTGTCGGATATTCGAAATATGCTGATGATTCACACCAAGACCACATTCCCGAACTGTTGAGACGCCTATTTTAAAGACTGTACGGGATTTTTGGAAAATTTAAAATTTGGAAAATGAAATATTCAAACAAAACAATTTTTTCGCTTCATCAAATTTCATAAAAATTTATGTTAATAAATAGTTTTTTATTGAATTTTAAAATTCTTACTCAAAACTTTCAAAATAATTAAAAAAAAAAACCAAACTTGTATATTTTTTTTTATTAAAAAAGTTAAAAAAAATTTTTTTTGATAATGGGTTGACACTGCGCCTTCAAAATTTGATGAAAATCTTAATACTAGATTTTTTTAATTTTTCATTTAAGACTTTTCGAAAAATTCGAAAGTTCAAAAAAAAAAATTCAAAAAAAATTTCACTCTAATCAATCCCCCGTCTGCAAAATTTTCGATAAAACGATGAAAATTTTGTGGAATAAAAATGTTTAATTTATCATTCTGAGGCACCACGATTTAGTCAAGATCTGGCTCCTGGGATTAAGGACCCGATCTTGAGTACATGATTCTTCATTTCCAGCGCAAAATCCTTAAATCCGGGATTCCACCGAATCCGGCTTGACACCCGAGGTGCCTCATCATTCTACCTTTAAAAACTCCAAATTATAAAAAATTCTGCAAAACTCTAAAGAAATTTGATTTTCGATTTTCAAAAATTTAATTTTTTGTATTAAACATTCAAGTATAAAATATTGATGAAATTCTAGAATCATATTTTTAAGTTTTACAACATTTTTTAAAAATCTACAATCGTTCACTTTCTTGCCTTCGAAATTTGAATGTGAAGAAAAAATTTCAAATTAGAAATAAATTAAAAATGTGCTCATAGAATTCTTTAAAAATATGCGTTTCCCTAATAATTTCCATGTTTCAGTCCCCATCGCCCTCCTACACCCCATTTAACCCGACGCCCGTTCACCGGAACCGCGTCCGTGCCGACAATCGCCCAATTCGCCCGGCGGCCGCAGGGGCTCCTAAGAAAACTGACCCCCATCAGGCCCCGAGATAAGAGCTTATGGAGATGTGGCTATAGAGAGCCCTACTACTCGGGTCCCAGATTTTGAAGAAAAAGTTATACTAAGGTATTCGAGTTTAATTTCCGCTCTGGGAACACTATTATCTATAAACGTATGACCCCTTTAAATTGAGCTCCAGTAGTCAAAAACGTCGAAAATTTTCAATTTTTTTGAATTTTTACTTGAATTTTTTCATCCAGTTCTAAAAAAAAGCTTTCAGCTCTACCCCTTCTTTCATTTGTCACCTACTGCCTCGCTTCATTGCCCTGGGGTTAATTAATTTTTTGATGCTTTTCTAGTCCCGCCACGGTTTTTTTCATTTCGGAAAGTCTCGGATCGATTATCAATTTTTTCGAAAATTTGGTAAATTTAGAGAAACTCTAAATATTATCGATTTTAAGATACAAATGATTCTAAGATTTTTTTTTTCAAATAAAATTTTGGAAATGTTTTTTTGTAAAAAAAAGTGCAAAAAACACTTAATGGAGAATTTTTAAAAAATTGGAAAAAATCTTGAAAGTTTGTCGATTTTTCAGAGTGCCTTTTGGAGTTACGTGTCGGTTTTCTTTCCGAATTTTCATCAAATTTACTTTCTACCAAAAAATCTCTAAAACGCCGTGGCGGGAACCTACTTCATTTTTATTCTGCATAATTAGACAAATATTATTTTCTCATTTCAAAACTTGTTACATATTTTGTGTTGTGAAACATATGTCTAAATTTTTACGGACTGAAAAAATATTCTTAATGTTTTTGAAATTTTCATTATTGGCGTCATCCATGTCTATTTGATTGTTTCCACACCCCCCCCCCCCCCTCAACGTAAAATGAAAAGAACAAGACGATTGACAGCTAGCATGTGCGACGATCAAAGTACCGATTTGATTCAGTTGAGAGGGAGGGACACGAGAACGCGAAAAAGTAGTCGGAAGCCCATCTAAAAGTGCTGGAATACATTGGCAATCGCTATGAAATTCGAATGACCGACGGGAGAGTCTGTCCATACGTGGCACGATGATCGCCACTGTCAAGGCTAATATGGTTTTGAACAAGGTAAAAATTTGATGAAAATTTGGTTTGCCAAAAGCTTCATAGTTTCAAATATTTTTCCTTAGGAAAAATTATGCGCCGCAGGCACGATACACTAAACTTTCCGCTTTTTTCTATTGCTGGCTTAGTTTTCGCAATTTTCTGGCTACCAGTTCTGCAAAAATGATCGATCCGTGAATTGTGCAAACATCTGAGTTACACAGAGAGTGGGGGCGGGGCGGAACATCGCAACACTGCCGGACCCATGGTTTTGTCCACAACTTTTTTTTTCAAGACAAAGTCTCGGACGATTGTACTTGCTTTTTCTCTTTTTTGTATAACAATGGTATTTATACTAAATAATTCACATATGGTAAATTGCATATAGCAAAAATGGCACAAATATCCTCTCAAATTAAGGGGAGCCTTAATCTTAATTAAATTGGATATCATTTTCATTCGAAAAGAAGAGAGAAAGAAGTAAAATCGAAACTTTTGCTTTTGAAAAAAATGCTTGATTTTATGTCATTTCCGTTGTTTTTTTTTCAGTATTTAACTTTTGAAAGATTTATTTATAAGGTTTGCGGTTAAAAACGCTGAATTTCGCGTTTTTCTTTTCTGGATTCAAATTACAAGTTTGTTAGTAACAAATTCGAATGTCAAACACGGAAAAATAAGCGAAAATAACAAAAAATCCTGTATTGTAACCACAAAGTTCTCCACGAGTGGTACGACTACCGTGGAGCCGACGCGCCGCAGGTTTGCAAAACAACGCCCACCCCGTATTCTGCGCGGCACTACACAATTTTCTATCTCACGAATAAATTTTTCAGAAAAGGCAGGCTTTGGTCTGTCGAAAATATCATGAAAAATCAAGTCTTTGTCAGGTTTCCAACGCTGGAAAAGGTAGGAATTAGGGTTTGTTACCAAAAATCGTATAATATTAAAATCCCAGTGCTTCTCTGTCTTTCAGCAATATCTTTTAATTTCCAGGCAGACGAGCGATGGGACAAAGATCTTGAAAGGCGTCTGATTTCTAGGGCAAGCGATATCTCGAAAAAGCACCGCGTGGATTCGATGCACGCGTTGCCGGACCCTAAAAACTGAAATTATCCAGTTTTCTTATTTTCTCTAATTAATCCGATCCTTTTCTTGACAAGATTAATATAAAGTAATTTTTATCGAAGCGATTTTTGCTCATCTCATCCAAATATGAAAGAACATTCGAAGAAAAATCGCCGGCTTCACTTGGAACCGCGGCCATCAGTTGAGAATGCTGAATATGTACAAAGACTGGAAAATATTAAATTTTTCTGTTTCAAATTTCACGTTTTTCGCGTTTTCCACAAAAAAGCAAAGCATTGTAGTATTTCAAAAAACACTCATGGTAAACGAAGGCACCGTGGAATACACGATAGCAATGTGAGACCGCATCGACCAAACTGGGAAACGCCTGCGCCTTTAATTATGTTTAATTTTCGAATTTCGAGTTTATTTTTTTCTCAAGACTTTTGCGACTTTTTTAATATTTTATTACTTGTAGCGCTGAAATATCACAGTTATTATAGCGTCCCACATTGGGGACATCAATCAAAACAGGTATTTTTCAAAATATCGCCGAAATCAATAACCAGTTTTGAGATGTTGCCACCCGAGCCCCAGGCACGGATAATACTGAGAGAAGTTCCGGTCCAGAATACCCAGAAAGAGCAACCACCGGGTTCAGGAGATCAAAACCGTGTCCCGCAAGTCGAAGGACCATCGGACGTCAGTTCGAGCCGGAAAATTCCGGATCACTTCGACGTGGGCCGCATCACGGTTCCACATGAATGCCCCCGCAGATGGCTCAGAAGTCAATAGTTCGAGGACGACGAAAAAGACGAGTCGAGAACGAGTGTTGGGCGGTGATCGAAAGAATAGGAAGCGAGGATGACAAGTTCGAGGCCTCTGAGCTTGTTCCACGAGTGTCGAGTACCGCGATCACGATTGGTATATCGCGTTGGATAAATAAGGAGAAAGCCGGGGCGAATTATCAAGATTACGAAAAAAATTTTGATTTTCAATCTCATTTTTTAAATTTCAGCACCTACTCTACGGCTATCGAGGCGGAATCCAACGCATAATTCTCTCGCATCAACAGACGGATTCGATGGACAAAGTATAACGATTCGCCGCTAGTGAAGTACTGAAAATCATCGGAGACGGTCTGTACGTAGTGGTTCCGACTCGTTCCTCATACTGGTCTAATCAGTCCCAAATATCGTTACAACAAAGGCGTCGAGCTTCGGATTTTCGTTATAGTGAATTGGATTGATTCCGAATTGTGTTGGACGATCATCAGACGCCCAACGATCGTTTGGACAGATGTCGGACCTATCTGTCTGAGTGCCGCGAGCCAATATTCGACGGAAGCTGCTGCTGACCAAGATGCAAATTTTCGCGTCGTACTCCGAATGTGCCATATTACTGTCAACGGAATTTAAGCACCTTGGTTAAAAAAAACGCGTATAAAGAATAATAGTTCCAAATTTTCAGCTCGATTCCCGATGGTTCCCCGATTCCATGGACCATTATCATCGTTCCAGCCACTCATCGAACAATCAGAGAAGGATCCGATTACTGGGCTCAAATTATGGCCAGCGTTAGAGTGCTCTCGATGATTTAGTCGTTACAAAGAAGGTGCTTAATCATTTTAATATTAAATTTTACAGCATGTATAATTATTCATCTATCAGAAACGGCTCCCGCCTGTCTCAAAGATTGGAGGGTCACGTTAATGTGATTCGCCGGTGCAAATCAAATTCGGAATCATTGAGTCGGCGGGTGAAAAATACGCGACGCAGGGAAGCATGATGGCGGTCGTGGTTCAGTGCTATCAGAACAGCACGTTTGCATCTTTCGAAGCACTTATCGCCGGACCCCCGCGAGTCGTTGATTATTACCGAAGGACGCTTTCTGGAATTATTGCCCGAAGACGTGGCGTCTCGGAAAATGCGTGATCAGTATCAGAAAGAGCACGTTGTAAGCACGATTTTCCAGAGAAAAAGGCTTTCGATAAATTTTCTTATTTTCAGATCCGAAGTCGGAAGTTTACCAATCTGCATGAACACAGCCGGATTATTGTCTTGCCTCAAATCACTACGAGGATTCAGCGAGTGCCTTTGATCACAGGTTTATATATTTCTGTATTTCTTCTTCACTGCCTTATTTTAAAAGAATTTTCCCGTTTTTTTTCTTTTGTTCATTTTCCCCTTTTCTTGGTACGCTGTCGTTATGTCCCCGGTACATGCTAAATTAACGTATATTTTTAATTAGCAATTAAAAAACTTCCTGATTAACTGCCCGTTTTTGGAGGAGAACCAGAAGAACGCAGACGAGTTTCTGAAACTGAAAGGGTTTGAAATTTTTACCAATCAAACAAACTCGCAGTTCAAAAACCATGCCGTCGTTGCTCAAGTTTGAAAAAACCACTAAACATATTTGCAACGTAGATTGATAGAATATCATTGGATCTTATGGATCCGCAATGGCCAGATCATATTGACATTTACCGTTTAATGGGTCGGTACCGCTGAAAAGTTGCTGGTCTCGCAGCGAACTACAGTAATCGGGAAAAAGCGCTGTTTATTATCGAGTTTTCACTTACTCAAAAAAGTCAATAAACTCGCCGCGAGATCCAAACCTCAACTTACGATAGCTATTTGTAGGAGTCGATTTTCCATCGACAAGGAAGCCAGCGACTAGGAAAATTTTGATAGGGAGAAGCATTGAAATTTAATTGTTTTGGGGCGTTGCGTCTGGGCCGTTTTTATAGGAATTTTTGAGCTGTAAGAAAACAACGCAACATTTATTGCCATCAATTAATACTCCGGAAAAATATGAGTCATTATGGGGGGTTTTCAACCGTACGGATTTTGACAAATTTGAAACTACCATATAATGGTTAGTTTTGTAGTTAGAGAACTCAAAATTGATTTTCTAAGACAAAAACATTGCTTCAGAAAATAGTAGGTTTGTATAATTTCCAAAAAATTATTTCTTGCCCAAAAAAAAAAGAGCTTCATTAGATGGCTGAACCAAAAAATTGGGCAAAAATAAAAAGTGTCTAATTTTGGGGTTTGAAAACGGGTAATTAATATATGCAGAATTCAGAAAATCTAGGTTTAACCCATCAAAAACCATTAAAAAGGGGGACAAAATTTGGCAATTTTTTCAACAACTCACAATTTTGAAACCTCCTCTAAATTGGTTCAATTTGTAGCTACAGAACTTAAAATTGGTCTCCAAGCCATCAACAATTGTCCTTTTTCAAAATATAATAGTTTTAAACGTTTCTTTGAAAATTTATTTTTCTTGCCCACAAAAAAGGACAGTCATTAGATTGTGGCAAAAAATTGGGCAAAAATAAAAACTTGTCTAATTTTGTTGAAAACGGGTAACTCATATATGCAGAATTCAGAAAATCTATTTAACACAGCAAAAACCATTAAAAATCTAAAATGATTAATTTTCTAGTTAAAGCATGCAAAATGGATCTGCGGGAATACCAAAAAGTTGTCAAGTATCGCAAAAAAAGTGGTTCAATTAAAAAAAAATTAGTCTGGGGTTAAAAATCGATTTTTTCGCCGCACTTCGCAACTTGGACGAATTATTCTTTCGCTGCACAAAGTGAGAATCAATAATTATTGATTTTATTTCTAAAACAGAAAAATAGATATTCACTTATCTGAAAAATCGATATTAAACGGAAATTCGCAAAAATCGATGGTCATTAGTTTTTTTGCAAACCAGTAAAATCGCTTTTATCCTTCGCCGCATTTCCTAACTTTTTCTATGCCACTTGACCTTTTTTCTTCCAGAAATCTTGGAGCTTCCCAAACCCACTCATCAGCCAGCGTGCTTCATCAATCATTCCGTTGAGAACTATGAATTTATCGAGTGAAAATTAAAAAGAGGGGGATTTATTACACTGAAAAAGTGTTTTTGTGCCACGTGGCGGCCTGCAGGCCGAACCTAATTCCTAGCGGGAATTTCTAGGCCATGTACTTGGGGGAGATGGGGAGATGATCGAGGGGTCAACTTCAGGGAAAATGTTTGTAACAAAATAGAAAAAAAACTATAAAAGGTAAGAGGAGATCAAAGGTCACGCAACTAGGGCTTGAAAAATGAATGCCTGCCTACAAATAGACATGTAGGAATGTAGGCAGGCAGACAAAAAGTGGGTGAACAACGAGAAAAGGCACGTAAAATGGGGTAAAGGTTAGAGAAAAAGAAAAAAAAAGCTCACAGAGCACATTAAAAATGGAAAAAAACGAGATCATTGGATATTCTGCTGCAGTTGATCGTCATCATGAGTGGTCTGCTGATTGGGGTCGACTATCACATCATCTGGTTCACGAGAGCATCTTCTTCGAGCAGCTCATGGATGATCGTCTTGATGATTTGGCTGTTCAACCACTTGCGAATTCGAGGACATCATTTACAAATTAGAAAATACCATTTTTTAGACAAGAAATCGATAAATTTCTGTGTTTATTACTATTTTTCGGATAATTCCACACAATTAGATAGTTATTGAGTTGTCTTTCTATAATTTTCAAAAAAAAAAATTGAACGATAATTATTGATTTTTTTTTAAATCAAAAACTTCACAAACTCAAGAATTATATATTTTTCGTCCTCCTTCTCTTTCGGTTTTGTGTTTGTGTAATGAGTTTTTTTGAAAAACGCAAAATTTTCTGTGATATTTCTATTTTTTAACCTGAGGCATAGTTTTTGAAAAAATTTTGCAATATTTTCAGTGTTCTTTCTCAGAAAAACTCGAATAATTGCAAAAAATGTAAAATTTATCAAAAACTCATTTTCAGTCCTTTGCTCAGAGAAGACTGGAAAAAAAATTTCAATTTTTTTGAAAACCTGCCAAAAAACGAAGTTTCACTCGCGAAACATTTTTTTTATCTTTTTTCGAAAATTTAATACATTTTTTTGCAATTTTTTAATATCAATCCGTTCTCACATTTTTTGGTAAAAATATGAGGAAAATGCATACATTTTGGATTTTTTCAGAATATCTGTTTACCATTATTCTGCTTCTCCACAGTAAATACTTTAGGTGCTCCTTCTCGTGCACTTCTACTTCCAAATTAACATCGTCACCAACTGTCCCAATAACATCTTCCTCGACAATTTCCTCAACAATTGCTCCATCAGGAGCCATATGCAAATGCATTTCTCGATTATCCATTTCTTCTCCAGCCATTATTTCGTTAAACTCCAAACGTGTGATTCACTATTTGCAAGAGACGATGTTCGCTTTTTTCGAAGAGCATTTTGAAGAGCAAATCGAATGTCTCGTTGTCGGTTGCTGAGCCAAATGAGTTCTTTGCAATACGGAAGTGAGCCTCGGCTGTTTCGACTTGTTCAACGCGCCATTCCAGATGGTGATAGAGGCTGGAACTATTACTCAGAAATTTCAGATTTTGTTTCGTAACCAAATGTGGGAGCTGGGAAATTCGCGTTTTCGACGAAAAAATAGCCTTTCAAAAGATTATTTTCAGATATGTTTAAAAAAATTGAAAACGACGAAATTAGACCTAGTAAAAATTGGATTTTCAGGCATATACACGGGCGTTTGATTACGTGGCCGTGAAAAACGGAGAAACTCGGCCGCGTAGAAACAAAACCGAAAATTGCAGAAAATCCAGGAATTATTTTTAATGACTCCGAAATTTCTATCCCCGATTCCGAATTATATATATGAAAGAATATATACTTCTGAAAAATTCAAAAAACCTTTGCTCACGCCACTAATTTGCTGAAGAGCCCAAAATTTTTACGATCCTGCTATTTCGGCTTTCTATCCGGCAGCTGAATCTGTTGCTGGACGTGGATGATGATGGTTGCTGAATCTGCTTCCGTCTGTGAAACCTTAAGCTCTCACTCGTCGAGCATCTCCTCAAGATGTTTCACATTTTTCTTTGATCCTCCTTCTGAAGCTTCTGCTGAAGCTCCAGCCGTGTCAGTCGTCCAATCATCCACAAAATCACCCGCCGCCGCCGAAACAATCATCATTCTTCAACTGGATCATGATCACCTCTCAGCATCCCGAAAACAATGAGTCGCCACAATCTCACGACGTCGGACATAATAGAGCCTTCGTGTTCTCCTGAATCCTATACTTCTCCAACATCACTTTAGCCACCTCGGCAGGGCCTTTCTCGCGTGCAGCCGGAGCACATCCTCCCGAAAGTGGGGTGGAAGACGTTGAAGTGAGTATTCTTGAGCGGAGCTCATCGTCTGTGGTTAACCGGAGCCGGCATATCGCCGGGCTCTCAACTGTACGATTAAATGAGCTCATTGCCGATTTGATGGCCATTCTGCAATGTCTCACGTAACGTCACCTTCTTGCGAAGGACAACGTGGAAGGGCAGTACGTGAAGCTGGAATTCGATGAGATCCGAACTATGGGATGATGGTGTCTTCCAGATGTAGTTGACCTTCTCGATTCAGTGCGAGCGCTTGTTTCGCAGATTTTGGACGTTTTGTGATGCCGTCTGAAAAACAGAGAAAAAATTGAATTTGGAGCATCTTGAATTTGGGTCCTTTTTTACTTTCCTACGGAACGTCCCACTTTATTTTTCGTGGTTTTTTTTCTGAATTTTGGATTACAGGGAATATCTCTCCAAACCAAGTACAGGGAATACCAAACTGTGTGGGCCGTCGCAGGAAGACTTCTCTACACTTATAAATTGTTTTACCTGTAGGCACATAAAGGAAAAGAGCAGAGCCTGCATCTTTGTATCTTCGATAAATTCGAGTTAAAAGTTCTTTTGTCTCTATTCATTTGTCATATTTTCCAATGTTTTAAAAACATTTTTTCTAAACTTTACAGTAATTTCGAGCGGGCTATTTTCACTATCAACTTTTTGACGCGTTTTTAATTCTTCATTTCAACCTCAATTTGTGCAAACTTTTCAAATTTCCATATAATAGGGCCGATTTGAAATTTTCATAATTTACACCAATATATTCAATCTTTAACCTCATTTTTTTCACAGAAATTCCCAACATTTTCACATATTTTTCATGACAAATTTGTATTTCAATGTTTTCCAAACTTACGAGGAATGGTGCTTGCCAGATATTCTCTGACCACGGAACCATCACACGTCAAATTTCTTGCATCAACCTCGAGCCCATCAATAAAGAAAACGAATGCGGCTTTGCCAGTTGTGGCTGCCGGAAGAGCCGGTACTCGATTGTGGCATAGGGACTCACTGCAAAAAAAGCATCGTTTTTTATAGAAATGGATCGATGTTTGTGTATAACTTTATCGATTTGCTAGAATATTATCGATTAGTTTCCGAAAAAAAATTTTAAAACAACCGTAAAACTGTATTTCTATTTTTATTTTTTTAAAGATAGACTTCCAGATCATATTTGTTTTGAAAATTTATAAAAAATTATCGATTTCTCTATGGAAAAATATCGGCTATTCTCGAAACTTGTGGATTTCCCTAGAGAGTTATCGATTTCTTCAAGGAAAAAATTATCGAATGTTCTAGAAGTTGTGCAAATTTTTCATAAAATTATCGACTATCTTTTACTGAAATATATAGACTTTTCGCCCAAAAAGTACGTACATCAAAGAAGGCTTATTGACAAGAGAGTAATTGTCGATTCCTATCATTCCAGAACTCCATATCCAACAGCTGAAGATACAAACTACCATCATTGGCGGCTTGTGCTGGCACAGCAAACGGGCATTCTTTCTCGCATTCCGCCATATCCGACACATCATTATCATACGATATCATGTATCTGCGTTGGCTAGGGAAAAATGGATCCTCATTTACACGCGTTGAGCACACACTTTGTGAGCCTGCGAGAGCTCAATGAGAACCTATGGTTTTGTGGCTCGTTTCGCGATTCGCAAATATCCGCCATGCATTCGTGGTAGCTCGCCTTCCTGATTATAGTCGTACATGATGCGCGCATGGCTTCACCACGAGCCGTGATTCGGTTTCCATATGTGATTGATTTTTTTGCGTAGTCGTGGCGCACGTGGATTGTTATGGAATACAGGAATACCAAGTGGAATGTTGGCACGTTTTGAAGTTGGGCCCATGTTGTGGGCCTTTGGTCTGTGAGGGCTTTGGGATATTATTACGGGAGGCATAAAATTCTGAGAATGCGCATTGCACAGCATAGCCCATAGACCAGATCCGTAAATCAACACAAGCCCAACAGTAGTTATTTAATAAATTACTGTAGTTTTTGCTGCGAGATATTCTGCAACGCGTCAAATGTGTTGCGAAATACGAATGCTCAGACGTAATTTTTCCTAAAGCTCGTCTATTTTTGTTTCATTCAGGGTTACTAAAAAAAAACCTGTTTTTAAAGCTTCTACATGTTTAAAAAGTTTTGAGAATTTAATACACTTTTTTTAATAGAAATTTGGCAGATATTTTCATCACCTCATCGACGATTATTCTTTTTGAACAATTTTCGATTTTTATGGGAATATATTTATATTCCAAGAAGATTAACTTTTTTTCAAGAAATATGAAAATTTATCGATTTTTCAAAAGAGATTAATTTATCAAAAAAAGAATAACTTTTCCAGAAAATATTTGTTATTTTCTTAGAAATTAAAAAAAAATTGTTAAATCGCTACGAATTTTGTGTCAATTTTTCAAAAAAAAAAAAGAGGCATCGAGAATATCCCATTTTTTTCGAAAAAAATTTTTTGGTTATCGATTTTTCTTTTTTTAGATAAAACGTCTCGTATATACTTTTTTAAAGATGTTTTTTCACCAACAAATTTTGATATTAAAAAGTTGGAATTTTATTACTAAATTATGGAAAACGTTTTCGATTTTTAGAAAATCGGAATTGAAAGTGGGCGCAAAAAATTTAATTTTTTAAGAAATTATAAAATAGAGATTATGCTCATTTTGGTATGGAGAGCGTCGATTTCCATCGGGCAAGATTTTTTTGGTTGTTTTCCCTCCATGTAACACCTGAAACTCGAGTGATCCCATGCTCATCACAAATCACAAGCTCCGACTTTGCGAATTTTCGTCCCCGATAGCACGTCGGATTCTGTTCATTTACATTATTAGACCATGGCGAGAAGTCGTCACGATTGATGTCCGTGTGGAAAGAGGGCTGGCGACGAAGAATGCGTACGCACGAGAGTTACGAAGTGCAGTACATTGTAAGGTGCCGGCTTCGCGTAGTCAAGCTCAGCAGACCACGTTCTTCGCTGGAAATATGATGACTATTTCGAAACATTTTTCGAGGAAAATGGATAGAAAAAACGAAAAATTCAATTTATTTCAAAGTTCGCTTATTGTTGATGAAAACATTATTACGGGAACACAAAATACTGAGAATGCGTATTGTGCAAAGTTTCTCGCGAAAAGTGTACTACAGTTAGGTGTTTCTTCAAATGACTACTGTACCTATCCTTGCGATTTACGGGAATAATTTATCAATCGATAAAACAGTCATTTTTAGAATTACCGTAGTCCTCGCCACGAGATATTATGCGCGTCAAGTATGATGCACGCATTCTCCAAATTTTGTGTTCCGTAATAAAGTAAAATAATGTTGTTAGATAAATATTCAGGGTCTCAACAAAATTTAATCTATGTTATCAGTGTTCATGTTTTTAGAGTGGAAAAGTTTTTTTTCAGAAAACAGTCAGAAATGTAGATTGTGTTGCATATTTAAAAAAATCATTTAAAAAATATGAACATTTTTTTGAAAAATCAAATTTCTCCAGATTGTATTACGCCATTAAAGGTCTCGGCACCATTTTGTTTCAATTTTTTGAAAGTTTTTGAAGTAGAAATATTTTTTTTATGAAAATTTTCCGTCGTTAGAATTTCGTTGAAAATTCGCTAATAAACGGGGAGTAAAAAAAACGAAATTTTCCAATTTTTCGAAAAACAAAATCGAAAAATTCCTCCCAAACTTACACATGGTATTAGCAATCCACTCCAACATGGCCTCAAACGTGCTGGCGACCCTCATTATGTCTAACAGTCAAGCACACTAAATATGTCCCGTTTCCAATTGCCGGGGATTCTCAAAATAGGGCGCCGGGTTCTCCTGCGGCTAGCGGATCATCGTCAAACTCCAAATCGTAGCCAATGTTGAGCACATCCTCTTGAGACATATCCAACAAATCATCGTCTAGCAGATGTTCCCTGAGCGTCTTCAGCAATCGAAACATCTTGCATTAACTGATGTTGCTGCTGCTGGTGCTGATGGGGTTGAAGCTGGATCTGATCTAGGGAATCATTGTGATGTCCCGGATGACTTCTTCTTCCACGACTTCCAAATCTTCTACATCTAGTTAAATTGTTCTTCATAATTCGGTGCGGCAGATGATGTAGATGGATCTTGTGATGTATCAAACTTCTTCATGGATGATCGTTGATCCATTTCGATCATCTAACACCTCTTGATGTCCAGGTGTTCCAGGGTCTGGTTTAACAAACGGACACGGAACCGAACCATCTATCACAGCTATTCATATATATAACACACATTTCCGATCGTAATCGTTTGCGTTGAATATAAATGAGACGCTTCCGAAGACGGGGGCATCTCGGCAGGACGGACATTGTTTCGACGAGACACAACTGTGTATTTAGAGTGCCAGCCCCGCCAGCCGTGTCTTTTGCCATTCGGAACTGGCCGTTGTCGTCTTGGACGATGGCGAGCTGTGCGGACGCGGGTGACGGACCTTCCGAGGCAGCTGAAATTAATCAACCTACGGCACTCTGTACATCTCCGGCACCACGTTTTCAGATCTACCCTCAAAACAAGATCTACTATTTGGAGATCTACGAAACCACTACTTTTCAAGAAATGGTACCATTCGAATTGCATCGCAGTATTCTCTAAGAACAACAAATCCAGAATGATGACCGCCCATTGTGCTCCGATGTCGGGTGTTGTTTAGCGTTTAGAAAAATCTTTTTTGAAAGAAAAACTTCAGCCGAGAGAACGATAAACAACGCACGATGAGTAATATGGAAGAGTTTTTGTTTCGTTGTTAGGAACACTGAAAGAGCTAGATCCTGAAAACGTATATCTTGTTTTGGTAGATCTTATTTTCGTAGATCTTGTTGTAGAACCGGCCAGATCTCGAAAACGTGATGCCTAATCTTCTGCAGTTGGCGAATTTTCACATATTTCAAGCTAACATATTTTTTCTTAAGCTTGTCCATCGATTTCTTCGTTTTCACGATTTTTTTCAGAGAAAATATAGAAAATCGATAAATTTGACGTTAAATTTTCGATTGAAAAAATGGAAAAATTACAGGAAAGTATTGATGGAGATTTAAACTTTCTAAACAATCGAAAATTATCCTTTTTCTTCTTTTGGAAATTTTTTTTTGGATTTTTCCCAAAATGGGGGATTTGAAATCAAAAAGCGTTAAAAACAAATACTTTTCTTTTAAAATTACCGGAAATTATTTTAGAAAATTTCCTAAAAACGTCAATAAATTAAAAAATCGAACAAGAGAAAGAGTTATTAAATTAAACAAAAACAATTTCACAAAAGTCGATAGCTATTGATTTTTCATCATAATTCCCTAAAAGTCGAAATTTTTAAACCTTCTGATAAATTCTTTTTTTGTTAAAAATAGAACTTTCGATTGATGAGAGAGACGTTTAAAACTTTAATAACTTCCTGTAATTTGTCCTATTTTTAATCGAAAATTTACAATTTTAATTTATTCATTTAAAAAAATCAAAAAACGAAGAAATTGTCCGTTTTTCTGGAAAAATTAATTCTTCGGCTCGAAATTTCGATGATTTGTTTTTAGAAAAAAATATGTAAAAAATTATAGAATTTCAAATAAAACACTGTTTTTTTTCTTTTGATCTTGAAATAGTAGAGCCCGAATTTCTTCCATAATCCAATTGTTCACTCAAAATTTGAAATTTTCGCATGACAAAATAACTTACGATTAACAGTCAACACGGGACCGTCCCTGATCGCCAGTATGATTAATCTTACGCTTATTTCAACAAAATTCGCCGGCCACAAAGTGCACAAAAACGCCGGTTGTCGGAATACGTGGCGGTAGGTACGGTGGCCATTCGGCGATTCAGACAATTCGATTGGCTCAGCAGCTCGGGCTCATTCACCAAATATCGGAACGGGAGACGCCTCTTGTTGTGGGTGCCGACCCAACCTCGAGTATGCAAGTTTTACGCGAAGAAACAATGCACCATCCTTCCACTATCTCGTCTTCGAACTGGGAATGTTTTTTTGATGAGAGAAGTTAAAATAGTAATCTTTAAATATCAGTTTGAATTCGCCGCATTTCAGTTGTGCACCTTTCGTGTATATTTACGATATGTTTAATCTTTTTCAGATGCTGATTTCCGATCTTTAACGGGTTTCCTTGATTTTCGTCGGTTTTTTTTGGATATGTGTTTTTGAGGTCGATTAATGAACCATTTTATTATCAGAAAGCTAGCAAAATGTTAAATACTGGACAGAAAATCCATATGCCACATGCTTTTCTCGACTGAAAACCGGAAATGTTGCTAGTTTTTGATAATAAAATGTTAAATTAACACATTTTCAAAAAAAAAAACAATTCTACAAAAACCGGTGCGACGAAAATTCAAGAATCGTTGCATAAACGGAAATCAAGACCCGATAAAGATTAAGCATTTCGTAACACCGAATTTGGTAAAACGACCACATGGCATCTCTAGCCCGAAAATTCGAAATTCTTCCAGCTGAAATGTCCATTAAATCAGGGAATTTTTCTGAATATTTCACTTAGATTAGGGATCAGGAAAAAATTTGGAGTTATAATAAAAAAAGTTACTAAGCAAAACGTTTTAGCAATTTAGGTTCTAATAGGCTTTACAAATATCAAAAAGTCCAGATTTTTCAATATATATATTTTTAGAGCCACAGATTTTTTGCTGTTTTTCAGCATTCTCGGAAGAACATACCGGTGTGGATCCGGGATCATCCAGATCTAACGAGACGTGCGGATCAGTTGGATCGACCATCGCATGTCTTAAATAGTCGTTTCCGTGCGGATAGTTTTACGATTGGAATTTCACCGGGACACGTGTAGTCGTAGAGAATGAGCACGTTTCCTTAGATTTGGCCATCGCCAATGGGAGAGGTTCCCTAGAAAATCTGGAAAAAATTTTGTGAATGGATTTTTTCGTTCTGAAGCATTTTTCTTGAAATTTGAAGGAAGACGGGTTTTGCATAGACTCAAAATTAACCCTTTAGAAAATTGTTACGTTGGCTCAAAATATCGAGAATAAAACAATTTTTTTCTAAAATTTCGAAAAAATTGGCATAATGGCGGAAAATGTAATTTTATTTGATTATTGTACTCGCCTTTTTCAGTTCATTTTGGGTTAAGCATTTTTGGCCCATAGGCTTAAAATTAAACTTAAACATTTAAAAAACGAAATAAGATATCTGCACAAAGCCAGTTATGGCCACTATGAACTAAAAAAAACATTTAAAAAAAACAACTTTTTTTTGAATATTCACACTTTCTTAAACTGATAATAAACCTTTTTTCTCAATCTTAACAGTCTCGGCAGCCACGCGCTGTACTCGGTGAGATGAAGTCGGCGATACGTGGATCCTTGTCCGATTGGAGCCGTCCGTTGAGACGAGCAACCGGATGACGTCGGACATTCGGTTTGATGACTGGATCAGTGTTGCCTACGTCGCCGCCAGTAGAGCTCGATAGCTTCAGATCGTCATTCGAGACGTCTTTATCGACATGATTTTGGAGCCGTCCACATGCGAAACAGGCTTTGTGTGGAACAAGTGGTGGGAGACGGGGTTTGTCCAGAAGCCAACCTCCTCCGCGACTAAAAATGGGGACCGTTGATTTTAGTTTTTTTTTTCTGGATTTTTCGGACAATAGCATTTTGACCATTTTCTTTATTTTTAGAAGTTATTTTTCTATATTTTTTCTCTAAGAACTATTGTAAAAAATAGTTCAATTTTTTTGAGGTTCTGGCGACAAAAATTTATTTTATCGAAAAAAATTTTTTTTTTTTAAAACAAGATATAGATTTATCACTGAAAATTACTAATTTCCAGTGCAAAAAATTTTTTTGCCTATTCTGGTAGCTGCCTGATTTTTGATATATATTCCAACACAATAAAGTTGCTGAAATTTTCTCCTTTTTTCACTGTCTCCGTACATCATTGCAATTTCGGTCTGTTCGCGTTGGTTAGCAGCTCATTTATTCGTTCATTTCTGTGAAGGTACGCCAGGCAGCCTGAATTGTGGCGTAGCAATCACCGTTTTTCGTCGAATTTCACCTTCATCTTCGAACTGCAAATAGACAATCATTGAAGAAAAAAAACGTTAAAATCCGACTTTCTCGATGATTTTTATGATTTTTAACTGAAATATTGATTTTTCGGCATTTTCTGAAGCAGATTTTGATTAAAATTTGAAGGTTTTTTTTCGTCTCCCGTAGGCTCAAAAAACGCCCTTTTTATGGCGGCTCAAACGCAAATATTAAGTAATATTCGAATACAAAAGTTCATAAATTTAGGACCCCTGCGGGGACATTAGACTTCAGATCTAAAACTAACCGATTTTGAATATTTTGAGCCAAGTTTGGCCAAATAGGCATTAAATTCACTCCAGATGACTAACACGTGAAAAAAGTTAAAATTAGGTAAATAAGACAAAAACAGAAAAAAAATAACTTGAAGCGAAACTGGAGCCCATTTTTGGAGACAATTCTCATTACAAAATTGGTTTTTTGGGAACATTTTTTATTCAAGTTATTTCGGACATTTTTTTTCGAAGAATTCCCATAAAACTTCGAAGCTTTTTCGGCATGTAAGCCCCTACCAATTTCACGCAATCTGGTACTGCCTTTCAGCAAGACCCAAGTTTACTGATAACTCTCCTTGAACTCGGAACATTTTCGACGGTGTCGCCGCCGCTGGATTTATAATTCTTCGCATTCTTCTACCATCGTCGATATACGACCCATCCGTATCCATTGGGCAAGCTTGCGTGTTCGGACACGTCGCTGTTTGCTGGGCCTGGAAAATTTCGATTTTAAAGTTTTTTAAAATAAATAATCCCCTACAAATTAATTTCCAAATGCGGCGGTTGCCAATCCATAAACCCGTCGTCCTCGTCCTCATCATCACCGAACGGGTCCATTTGTATGCGATCGCTCGTCTCGATATCTCGAGGGGAAAGGTTTAAATAGGCGGCTCATCCTCTACGATGACCTCCGTCTCTGCTCACGTGTACATCGTGTCGTCGCCGGCGAAGATCGGCTCTCCGAGCTCTCCGGCGGTGAGCTCCTCGAAATGTGGCGCTGGCTTTTAAGCTCTTTTTCACGTTGCGAACCGTACTTCCCTACGTCCTGCGTTTTGGAGCTGCGATCGAGCTCGTCTTGTGGATGCAGAGGCGAGCGCTTCTTCCTTTGGGTTGCCCAACTCGTAGTCTTCATTGTTGTAGAGCACGTGGGGATTTCCGAGCATTTCGACGTGGACGATATTTTGTGGCTGGATCCTGGGGCTCTGCGGCCGCAGGCTCTGGATTTGGCTGGGGCTCTTCGGCCGGCTGGCCAATTGGGGCTCTGTTGTGCACAGGAGAGAGCGCTGTTGATCAACTTGTTCCTGATTTTCTGCCAATTCAATTTTCAGGATTGACATTCTTCTGCAATTTAATAATTGAAAATAAGAATAATTAAGTGGAAAATTAAAAATTAAACAAGCATTAAAATAAATTTGAACAAGTCCAGATTTGTAGTCCGCAACGCACGGACGAACGCATACACCACAACTAAGAGAGACGGGAGGAGGGATGGAGAATTTGAAAGAGATGGCTAGGCGACGAGATAGCCGGAGGATTGAGGAAGGACAAACACACAGATGTGGGTTCTTGCAGCGCTTTCTCTGCGTCACTTCTTTCGACATTTTTCGGTTCAATGGGAAATTTCTACTTTTTCGGAGTTTTTCTTTTTTTTCATCGGAAAACTTCAAAAAATTCAAATGGAAACTAGGAGCTGTACGGACAATGCATAGAATAACACGAAAAATGCACATTTTTAGGCCTTAGGTCACTGTTCCGGCGCGGAAATGCGGATCAATTTCTTTTTGAATTCAAAATAGAGAAACTGGACGTGATGGTTGGTACAAGCGTTTAGTGAAAATGTATCACAAAATAGGAGATCAATTAGATATGTTAATTTATTCGTGGACCAAATGACTATAAAAAATTGCGAAATAAATAAAAGTCGATTAAAAACAATCATATGTCTTCATTGCTTGGCGAGAGTTTCTCGGTATCGGATAAACTTATCTCCTACAAGAGACTTGCGAATAACCAAAATAGTTTAGTAATCTAGACATTGGGTGGGGTGGGCCCAAATATTGAATAAGGGTGAAGAAAGATTATTCAAAATACGTCGCTGAAGTGTTGGCATACAATATTGAGTCGGATAAATGGTAAGAAAGCATCACCACTCAACTCAGATCACAATCTATTTCTCTGAAGAAGAAAGGGACGAATGTAGTAGCTTGCTGAGGGGGGGGAGGGAAGGGCGTGGGGATGGAGGCAATTTCAAATAAATCTGAAAGCAAGTTACAAATACGCACAGCCAAAACGGTGAGGCCGAGACTTGGCAAACCCAGTGATTGCAAGAATTCGATAAAAAGCTACTCGCGGATGTTAAGAGCGAATCATTTGGATCTCGGGGGCAGTAAATTAAAGGGACAAGGCATTTCGAAAAATACACACGTTAGACTGAAAAAAAAAAACCGATGTGATCATTATGGGATGCATCACTGCTTCTTTGGTGGGTCGAGTTGACACTGAGGCGAAGGAATGCGGATTGTACCGCTGCCACCGCCATATCCTTGTCTGTCAGTTGCTACATGCTTGTTGGATACAGATTTGTAGATTCCGTCTGTATAAAGCTGCTTCAACGTTGGTGCCGAGGGCAGATGTTTCTGAAAAATAAAGATATATCAGCGCTATAGATTAGTTTTACTTACCAATAAACCACAATTGATTTCTTTCGGTGCTGTAGATCTTGGCGTCCTCGTCTGTTGAAACTGATTGCACTGTAGCAAATGGCGCAAGTCGCTACCCTTGATTTCCGATCAACATAATAACAATGTTATGATCGGCGTGATCACGAAGCTCCTTCAACTATCGCTCTACATTCTCTTACGTCTAACATGAAGCTTAGTGTCGTAGACTAGGAGAGCTCACAGCCCCACGATAGTAAGCGGATATGATGGCACGGTAACGTTACTTTTCTGTCCAGCAGTATCCCAAATTTGAGCCTTCAATGTCTTGCCTTCTACCTATGACAAAAATAATAATTTGAATCATAACATTAGTGTATGCTACTGAAGTTCCTCACCGAGATGCTTCTCGTGGCAAACTCGACTCCGATTGTTAATTTTGATTCCAAGTTGAACTCATTCTTGTGAAACGAATAGACAGGAGATGTTCATCGACTTTCCGACGGCTGAGTCTCCAATCAGAACAACCGAAACAATTTTTCGTTTGGGAATTGAAAAAAACAAAATTACCGTTGAAACACAATTAGTCGTACTGCATCGTCACGAGAGCCCATCTTCTGCGCTGTAAAATGATAAAGGACTTGTTAAGGTTGAAAGTTATATATTAGGACGATTGTAAAAAAGAAAAAGGGCATTGGTCTCATGATTCATCAGCCGGGCGCAATGTCTTGTTGTAAAATCGATATTGAAAACGAACACTGTTTTATCGGCGGAGCATATTTCTATGTTCTGTTCCCGACACAAACGCGGAGTCAGCAACCGCTATCTCGACGCATGGGATTGAAAAAATAGAAGTGAACTTAATTTAAGAATGATTCAAAGTATATGAGTTGGGAGTTTTATATTGTTATCAATATATGAGGGGGGTGTCACCTTGAAGGAAAATGTGAAAATGTATATAGAAGTGTGTTAGGCTGAAGAGTATTTGAGGCATATCATACCCGAAAAACAGGGAAGGTGAGCGGCCACTTTGTTTGTCGACACGATTTCGAAATAGTTGAACTATTTTTTAACGGGAAGAAGCTTTCTCTGGGTGTTCTTTTTTGATATTTTCAGCTAAAAATTGAAAAAAATAATTAGTTTTATGGCTGTGAACATCCACAACATAAGCTTTTCCGAACGCGAAATGCGTGTGAAACCCAAATAATTGAACGTAACAGGTCCACCGGCGCGGCCACGGCGGTCTGAGGGTACGCGACGCTAGCGCAGCGCAAGGCCGGGTCCCGGCACGACAGACTACCGTATCCCTTTAGCAGCGGCGCAACGGATCGTATCTCAATTACATTTTTTTTTTTTTGAGACTAACGATTTTTCCGTTTTTTCAGAGCAATATTTTTCATTGATTTTCTTAAATTCATCAGAATAAATTTTAGAACCTAATTTCCCGTAATTCTGATACGCGTTTTTAGTTTTCGTGAAGAAAATGCTGATTCGAAAACTGAAATAATTTAGTTTTGAAAACTTGCTCTGAACTCTGTTTCAATATCTTATAATTTGCTTCTTTTCTGAATATTTTGATTTTCCTCAGGTAACCAACCGCCTATACTCCAACGTAAGGTTTTTCTTTAAAATTTATATTAGATTGAAATACATTAGTTTTAGGCCTGATTTTCAAATACTTCAATTTTGATATTTAATTGTTGGTTTTTCAGTTGAAAAGAAAGTGCCACAGGTTCCAGAAACTGTGCTCAAGCGCAGAAAGCAGACGATCCTCGCACCAAGGCTGGTCAACATTATACTAGGTGACCGTCTCTGTAAGTTTATTTAACTGTCTTGAAAGAAAACCGAAAATGTTCTTGCGCTGGTTTTAGGATCCACTATTATCCAAGGCTACCAGCAGTCAAAACTGGAAGCTATAAGATCTTGTTTTGGGTGAGGTGTATTCAATTCAGAATGCGTCTCATGTTTATAACACGATGACAATTCGAAATTTTACAGTTTAAATTGTCTTTTAGGTCCCGTTTGAAAATTAATTTGTACTAATCATGCATTAAAAATAAAATTTTTTACAGAAGAACAAGGGAAGAGAGAATTCTTCAAGCGTGCTGAGAAAAACGTCCAGGAGTACTCTAGAAACGCCCAAAAGGAAGGACTCAGACTCAAGCGCGAGGCTGAGGCCAATGGGTGCGAGACTTCTACGTTCCAGCTGAGAAGGTCGCCGTCGTCAGACTTCGCGGTATCAACCAGCTTCATCCAAAGCCAAGAAAGGTGAAATTATGTTAATGAGTTTTTTAATAACCATTCGTTTTCAGGCTCTCAAGTTCCTCCGTCATAGTCAGATCAACAACGGAGTGTTCGCCAAGCTGAACAAGGCTACTCTTCCACTTCTCCGTATCATCGAGCCATACGTAGCTTGGGGTTATCCAAACAACAAGACCATCCACTATCAGAGTCCTCTACAAGCGCTAATCGGATACGCCAAGGTTGACGGCCACAAAACCGCATATTGCAATCACCGACAACACCATCGTCGAGCAGAGCCTCGGGATAATTTGAAAACGTATGCCTTTTAATTCTTATTTAATTGTTTTCAGGAAAGTTCAACATCATCTGTCTTGAGGATTTGGCCCTGGAACGAGATCGTCCCTACCGTCGGACCACACTTCAAGGAGGCCCACCAACTTCTTGTGGCCCTTCAAGTTCAACAACCCAACTAAGATGGACTAAGAAGACCAACCACGTCATTGAAGGAGGAGACTTCGGAATCAGAGAAGATCAAATCAACAACCTTCTCCGAATAATGGTCTAACTTGTTTGGTGTTCATACCTTCCTCCCGGATAAATCGTTATTGTTTGACGTTGTTTAATTATGTGCATAAATAATCATGAAACGTTATCGTCTTGGCTCGACTCATCTCGGATTTCATGAAGGGTCTCATCATTCAGATGAATTCGTAAAACCGCTTCCCTTGCTGACTACTCTCCCAAGAACAGTCACTGTTCCCTACTATGCTCCATCCTGTTTATTTCTAGAAACTTCGAAGCGATCCTAATTCCCTATGAAGTGAGAGAATTTAGGTTCGTGAATAAACATAGTCCAGATTTAAATCCACGCAATGTCCTCTCTACAATGTACTCCCTCTTGAGCACCTTAACCCATTGATGATGTAGATGGGTATTTCTTCAAAAATTTGATGGAAGGACTTGATTATCTGCTCGCCAAACGATATGGAACAGTTGCCTTAATACTAGAATTATCCTTAGAAAAAGCTTAAATATTCTTCCAGTCTCTGGACTCGGGCCTGACTCCAAAAGAGCGAGCACAGGCTCTCGCATTGCGCACTTTGCTCGACGTGCTTGGATGCTTACACGCGAGGCCAACTACGGATTTCATGTGGCTGCGCGATTAAGAATAGACTTCGGGCTTGGTCAGCTCTATTTTTGGAGGAATTGGGTTGTACCCAGATGCAGAAACGGGTAGATTATTGATATTTTATGGAAAAATCGATAAAATATTGATTTTTTACTGGAACAAATAGATCAAAAATCGGTTTTATTTTCCTCGGAAAGTCAATGCCGCTGTCTGAAATTAGTAGTTTCTTGTTGATACAAGTTCGATAAAACTGGTTTTTCAGAAGCAAAATCGATATAGTAAGCCAAAATGACCAAAAATTATCAATTTTCCTATAATATTTACCTTGGTTAGATTATCGATTTTTAAGGCAATAAAGTCGATATTTCACAATTTTTTATTTTTTTTTGGCTTTCCAGCGCGCAAACTGTGCCAAGATCTAAATTTTCCGAAATTTTCATTTCTGACACGCCGCCGAGTGCGAGGCTACGGAATATCCGGAAAATCGGCATGCGAGAAAGGAGGTCGCCTGCCGAACAAACTGAAGCTGTTGGAGGCGGCCTCCCTGACTTTTGGCTCGAAAAATACTTTTTCGATGTCAATGCACCGTCTTTGGTAGGTGGCAGCCAAAAAACTCGTCGGAGCCAAGACTAGGTTTCAGCTCGACTGCAAGGCGTTCGCCGTGATGGCTCAAATATACACCACTGCAGAACGAGGCCCGCGTAAAACAATTCATCCCGAAACGATCTCCAAATTTGTTCGGTGGCCTTGAGTTTTCTAAGCCACGAGAGTTGAAAAGTTCTATAATAGGGCATTTGGTTTCAGATGACATTAGTGACGGGCACACATGAATCCAGAGGAATTCTGGTCGGATTGGTGTATCACGTCGGAGGATTGAATTTCGTGGAAAATGCTAATTGGTTTAATGTAATATGATTTTGCTTCGTGGATTTTAACCTATGCACGAATAAAATTTATATTCTAATTTTAAAAAAATTTCAAACCAAAGAATTTTGAGTCTTACGTGACAATTGAAGGGTATTGCAATATGGGCATAAAAAATATATTCCCTAATTTTCGAACTTGCTCAGTCTTGGTTGCGCAGGAAATTTTTTTGCAGTTCTTGTTTGGGCCTCGGAGCTTGCGCAGATGCATAATATTTGACGCGCAGAGTTTTAATTGAAGTTTGAGCTTGAATTGAGTTATTGAATTTTAATTAAATAAAGCGAATTCTAGATAAAATGATGTGTTTATTGCAAACTAGATCGTGAACCTACAAAACAAAGACTTTACGCGCAAATTTCCGAAATTTTCAAGAAAAACCAGTGGAGGCAGAATTTCAAATGATACTTGTTCCTCTTCTATTTCTTCTACCAATTTTGTTGTGCGGTGGGAATAAGAAAAAAGCGAACAAAAATGATGTAAAAGGCGTCGAAAGTAAACCCACTGGTTCCACCGTCGACCTCTACAGACCTGCTGAAGACTAAAGAGAAGGAGAAATGAAAAAAGAAGAAGCTCCGGGAGCACGACGCCCCGACTCAGCCGAAAAGTCCTCCGAAACCAGTGGTCCAGGACACGAGAACTTGGTTAAGTGCTGCCTAAAAGTGAGAAGGAAGACGAAATGAAGAAGGGAATTCAGTTGCGAATCCGCCGAAAAATTTGGTGGGTCTCACTGCGATACATTGAGTGTTTTATCGATTTTCTCTGAAATAATTGATTTTTTCTGTAAAATTTTTGACCGCGAGATTTGCGAGTTTTCTGAATTTTCAAATATGTCGATTTTTCAGAAATGCGAAAGTGAAATTTCTCAAAGGAAAAGCCGGCGGCTGACAAAGAAGGACGAGAAAAAAGAAGCAAGATGGCCATAAGGAAGAGTCGAAAAGAGGGAAAGGAGAATAAAAAGGAAAATGACCAAATTCTGTGAAAAATTTCGATAAATTGGTTCCTGAAGAAGTCATTGTTCATTGTCGCTTTTTCAGAATTCCTCGAAATTTAATTGGGCGTCATGCTTCATATGTTGCATTGAGTCCAGAGACTTTCAAAGTTCACGCGCAGCAGACATTTTAGCACGCGCTGCAGTGAAATTCCTCTTGGTGAAGATCTTGATTTTTTCCCGCCTTTTTTGAAAATTTTCGAGGCGTTGGTCGAGCCGAGTACATGTGAAGACGGAATGTCAAATCACAAATACATCACATTTGACGCGCAAAAAATTCGTTTTGAAAATATGCGCGTCGAATAGGGTGCATTGAGTACGCGGAGCCAATACTAATCACACTTTCTTATCGTGGAAAATGGAGCGAAATTTGATTTTTTGATATTTAAATATTCGGGAACAGAAAATTCGGAGAATGCGTATTTTGAAACATAATTGACGCGCAAAATACCTTCTCGTACAAAGCGAAAACTACAGTAATTCTTTAAATGACTACAGTAGCACATGTGTCGCCGATTGGGCGTGATTTTTATTCCATTTTCTTCAGTTTTTCTTGACATTATTGTGTTTTATTTTAATATTTTTACCGATTAATAAATGATTTCCGCAAGATAAATCGAGCTCACAAACGCTACAATTGTGTCATTTAAAGAACTGTAGTCTCCGCTGCGAGATATTTTGCGCGTCAAATATGTTGTGCAATACGCATGAATTTTGTGGGCACGTAATATTTGAGCGGCTGTTAGATAAAGATCAAAAAATTCAAAAAAAAAAAAGATGTCAGAAATCAAAAATTTTTTATTGACGCAATGCACAAAGTCTCCTGTTTCCCTTTTCCCCAAAGTTTTAAACTAATAATAAAATTTTTTAATTGTCCAATCCGACCAGTTTAATACGAAACAAAACGGACAAAAGATTCCACAATTCCGATTACGGCTCAACACTTTCACTCAAGGAATTCTCTACGCTTAGATTTTGATCTTAATGGAAAACTGGTAGAACTTGGTATAAAACTACACAAAACTGGCAGAAAGAGTACTCCTTCCAAGACAAATAAAGTCCCTAATCGAGGAAGATCACTTGGAGCATATTCTGCCGCAACGCGTTTCTGCGCCGTCCCTCTCCAACTCGTGTATTGCGATTGTGGTGTTAACACTAACAATTGCCTATCAGGCACTGTAGTGGTATTCATATAATTCACTCAAATTTGCTTAACGATGCCCATTTTTGCCACCTGGTAATTTTTTTTAAAAAATTCAGAAATTTTGATTTGGATATATTCAAATAAAAAAAAAGTCTAAATTTATTTGCAATCGTTTGAGATTTGACATACATTCCAAATCCTACTCTTCGCAATTTTTTAGTCAACTCAACCTCAAAACCTTAAAAAAAAACCGCAAACCTGTCATGGCGCATTACGTCGATGTTATCCCTACGATAAATCTTCTGTTTTCGAAGGGTTTTTCATTTTCCAATTTTTATCACCAAGGAAAATGTATACACCAAAAAATTATATAGAATGTGACGTGTAAATTGGCAAAAAACTAATAACTTGCGCTTAGCTTTAAATCACTGCATTGCCTCTGCGGACTCAACACACCCGATCTGAAATTTCAGGAACTTATCGATTTTTGCCTAAAATTTTGCTGCATGGCTGCATCGATTAAATATTAAAAAAAAAAGCTGTTGAAAATGATCGATTTTTTTGAACACGAAAAATTTGTGGAAAATATGAAATAAAAAAAAACATTGTGCATCGAAAAACTTACAGGCTCGATACCGTGAGCTCTGGACAGAACAAAACTGAAGATGGCTCGGAGTCGCGGCCGGGACGAGTAGCTCGTGGCCCGAACCAAGCGAGAGGTTAAAGGCACATGGCTCCTCGGACAGTCCAGACCGATGAAGCAGAAATCGACGACAGAACAATACGCCGAGGCCGCTGGCGGAGGCGGTGGAGCAATACCGAGTGTAGACGGGGCAGGTGAAGGACCACCGGGTGATGGTAGGTTTTTAGATTTGCGAAGCTATCGTGGTTTATTGGTTTAGTTTTACAGACGGGGTCGACGGAACGGAAGGAAAAGACGGTGCACCTGGAACCGATGAAAAAGAGTCAGGTACCACAAAGACCCGGCGACGGAGGTAATCAACAGGTACCATCTGATGCATTTGAAGCATGCACACGTGAATGACCACCAGGACCGCCTGAACCAACCGCCCGGAGACAAAATCTCGAGGCTACCCTGGAGAAATCTGGGAAGAGCCAGGCACCCGAAGCGCCGGACCGAAAGGAAATGCTGGACCGTAAGTGGAACTACAGAATCGATTCAGTCTGCGGTAAAAAATCATTTTAGGATAAAAATCGATAATTTTCATTTTCGTTTTCCTCCATTAATTTATGTTAACTTTCTAGAGTTGGACCAGGTCCACCCTATCCAGGACGACCTAGAGAAACCGGAGATCACGGAAAGACGATCGCCGGAGAGGCGCCACCTGGACCACCAGACGACAGAGGAAGGAGAAAGTCCACAAGGACCACCGGGACCATCAGGGCCACGTGGAAAGAACGGAGTCGATGGAGAGAAGGGTACGAGATCAAGGTAATCCGGGACCATATGGAAAACCTGGGCAACCGGGAGCTCCAGGACCCGATGGCTCTGGTGGTGAGAAGGGAGGTTGCGATCATTGCCCACCGCCAAGAACTCCACCTGGTTATTAAAGATTCTTCGATTAGTTGATATTTTATTTTATTTGATCATGGCGTTATTCATTTTATCCTTCGGTGAAATTTCTTTTGTTGCACTATGATAATAAAATTCTCTTGCCAGTAGTTCCAAGTGCCCCAACATATTTTGGAGTCCTTTATGTAGATCCCTCTCGTCGAAAGCTGGAAGATTTCACAATAAATCTTTCAGAAAAATCGAATGAAATTTTAGAAAAAAAAACATCAAATTTTTGACGAACTGCATAATCAGTCAATATTCTATAAAAAAAAATACGATCGCACAATAATAAACAACGACGCGGAACGACACAGTCCGCGGTTACTGAGCTCCGCCCACGATTTCATTTGCACTGCGTTGAGTCGGCCGTGTTGTTATTCAAGAGTGAATATACTGGTTAAGTTTAAAAAGTTGGGTGTTTAGTGTTGAAGAAAATAATTTTTTTATTTTGAATAAAGCACAATTGGCAGCTGAAACTGGATTAAATCCAGACAAATTTTGAACCGTGGTTGTTGATGCATTGAGTTTATATTGTTAGTCAAATGTATGAACTTGTAAAGTGCTTGTAAATGTAAGTTGCTTGTTCGCTCATTCTGAAACAAAATTTAAATTAAATAAAAGTTCACGCGTTGATACAAAAAAGCCAAACTTACTGATTGCAATAAAAATAATCATTCATAATAGTTTTTAACAAACAACAATCCAATGCGATCAAAAGTTCGGAAGGTGATTTACAACCAGAGGACACCCAATCCAGAGAAGATAAAGAGACGACTGCTACGTATAGTGAGGATACAAAGCCACGTAAATAGACCGAAGTAGTCCTACTTTAAAATAACAGTAACCCAGCTGCCTAAATATCATAATAAAACTTGCAAAAAAATGATGTAAAATTTTAGTTTTTAGACTTTTGAACTGGTAGAAGCTGTGTTAGCGCCACTTTTTGACCACGTCTAAATAGAAAAATTTCCCATTGTAAAAGAGTTGTATTATGATACACTGCGTGGCGTGTAAAATACCGAAAAATAAAAGCGCGGTTTTTTTTTTCGTAAAATCACAGGGAAAAATCCGTAATCCCGGAACTCCAATCAGCCGCCAACATCCCACGGGCCCAATAACTTCTGGGTTTTCAACAATCTCATTTACTCCAATTCCCGAAACCCAATGGGAAGGAGAGCTAAACGCGGAACGGGACTGCCAAGACCCCACGCTATCCAGTTAGTCGTCCGACCAACGCCTCTCACACCAGCCATCACGCCATGCGAAGCACCACCACTACCACCTCCACCAAACCCTCTAGCGATAATAACAACTTGAAACGATTGAAAGTCAAAATCAACTGATTGAAGTGCCCAGCGATGAAGTAGGCCGAGTAGATTAATATAGACAATTTTCTTTCATTTCATGGGAAGGAACGAGTGTGAGGCGATGTTGAGCAAGCATGAAGACGATTCGAATGACGGAAATTAGGAAGAGGCAGGTCGCGTATGTGATTAGTATCAAGCATGGAAGTATCAAAATATTCACGTGTGTAACGGACCAAGACGGTGGGAGTTGTTTGGTATTATCATTTAGTTTCGTTTCAAATCAGACCGAGATACATACATTGAAGTTCAAATTTAGAACATGTTGCATCGCAATGTTGTAGTTCATTGTGCTCCCTGAAGCATTTTGCGGACACCACGAATTACATAGAAAATAAATATTTTAACCTATGGTGGGCGGCAAATTGACAAATTGCCGATTTGCTGAATTTGCCAAAAATTTTCGGAAAATTGTATTGTTGCACATTTTTTTTAAATTTCAAAATTTCGCAAATTTTATCGGCAAAATTGTACGCATCAACCCTATTTTCTACATCTGTTCCGAAAAGTAATTATATGAAAATATCTTAAGAAAAGGGGAAAAAATTCGAAAAGGCACAGTTTTCAGTGTTTGCGTCTTGTACAAAAAAAATCTCGAAAAACTTTCGGCCAGCAAACCGCCAAATTGCCGGAAAGGTCTTATAGTTTCAGCTAGCAGTTCGAATCGGCAAACCGGCTATTTGCCGAATTGCCGCAGTAGCCTCTCACCCCTGATGCTTTTGAACATGGTGCATTGCATCACCCTCGACTTGGAAAGTTTATATCGGTAGATATTTGCAGAAGATGTAATTTAATGATATTGTTCAGAAAAAGCTCTGGACCAACAAGTACGCCTTCAAATCCATCTGTGAGCTTATTGCCTATCACAAGCGAAATCACAAGCAGATTTATGATGACGTTGATCTGTGGCCTCGGGCACGACATGGATGGCAGCTGAACAACGGGCAGGTCACATTGATTAAGAGCGAAGTTGGGAGAGGGACAGTTTGGAGAAGTGCACAAAGGATTGAAGACATCTTGCAGCCCCGGTCACTGTTGCCGTGAAGACCTTGCACCAGAGGAAGGCGGCCATCTATCCGCCAATGAGAAGATCTTGTTCCTAAGAGAGGCCAATGTGATGCTCACCCTGCACGGTCTAATGCTACCTGTTTCAAGTTGAACTAAACTAAAATTCATTCCAAATGTGATAAAATTGTTCTCTACGGAGTATGCTCCATGAAGGAGCCCATAACATGATTTGGTCATGGAGTTTTGCGACGAGAATTTGAATCCCCCTGGCAAGGACGCTCTACTCTCCAAGGAAGAAAAAGTGTCAGCTGAGGACAAGATTCTCTACCTTTTCCGCATAACGCCGCCTCCGGTATTGGTTATTTGCACGGAAAGGTTAGTCACAGGGAGCGGCGAGAAATTGTTTGTTGAATTCCAAAAAGATGTTTGTTTTTCAAAATTTCTGAAATGTGTATGAAAAAATAAATTTCAGCTGAAAATACTTTGGATTGGCGGTCAAATGAGTTGCTATAAAGGAGCGAAAGGGAGGATGTCTGCCGGTCAAGTACATGGCTCCGGAGACATTGAAGAAGGGGTTGTACAGTACTGCCTCTGATATTTCTAGGTGAGCCTACGAGCATACATATGACATTGGTAGTGGCGTCGTGGCCTAGAAACCTTATCCGCGTCTGAAGGATAATAACATCACACAAGTCTCTATGATTTCCAGCTACTGCGCTCAAATGTACTAAGTCTACACGGACAGAGACGCCATTCGAAACGTGCGGGCTACGTGGAAATGAGCTCCGAAAAGCGATCATCGGGAAGAGAATCAGCTTGCCCGTTGAGGTAGAGCTACCAGTCTTCATTGCCAACATTTTCGAGCAAAACAAAGCAGGCAGTACGAGACCGAAGATCGCATTAGCTCCAAGCAAATTATTCAGATTTTTAAGGAGGTTTGTGAAGCATTTTATCTGTTTTTTGTTCAAAAAATTTGTTATTTTCCAGGAAGTCGGATTCCATGAAATTGAGACAAGTGGGATACTGCATAAGCTTGTCAATTCTCCCTTCCGAGAATTCACAATAAGGAAAGTAAAGGCGCTGGCAGTGTAATAAATATCTGAAAATCCCCCCACCCCTGAAAATATTTGACTGTATTTTTTAAATCACACAACGCACACAAAAGACAGACAGAAAGCATAAGTACACAGAGAAAATGTTTGAGGTGAGGTGCGGAAGGGAGGCTAGAACCTACTTTACGCCTCCCTAACAAGTTATGACTTTTTGGAATTCAAAATGTCGTTTTTTGCTATTTCACTCATGCGCTTACGTACAAACCTTCCTACCTTGTCTGCCTACCTCCCTCCTATTCTCTTATTGCAGGATTTTTGAATTTTTCTGAATATAAGCGTCTGTCGTACTTGTGCGTCATTTGCAAACAGGCTGTTCTCCGTTTTAGGGGGTGGCAGCACCCACAAAAAAAGACATAGGAAATCGGACGGAGTGATCTACTAGATCAGATGAACATTAGACATCAGTTTGGACCTAAAGTTAAACATTATTAATTCACAATGGATTTTCTTATTGTATTTCTTGATATAGCCCGGTTGTGCGGTATTGATACCATTACAATCCACTAAGCTAAAGGCTGTCATGTGGAGCCGAATGAAAAAAATCCTGATGATACATCGAGCATGCGGCAGGCGTTGAAACTCGGCAAATTAAGATTTGCCGGAAATGTTTTGAGGGATTTTTTATAAGATTTAAATGTGACTCCCTTTCTGAAATGCATGTGTCCCGTAAGTTTTTTAACTTTAGATATTTTTATAGGATCTCACTTTTCAAAATAGACGTAGGAGAAATCATAGGATGCATACACCTTTGCCGATTGAAATTTAAATTCTGAAATCCTTCCAATAAAAGTGCATCACCACAAGTTGCCGACTTTTGGCAATTGCTCGTTTCTCCGGCAAATTCGACACACCTGGCCTAATTTGCCGATTTGTCGATTTGCGAGAAATTTTAAATTCCGGCTATTTTTCGATTTGCCAATTTGCCGAGCAATAAATTTCAATTCCGTCAACTTGCTATATTGATCGTTTGCCGCCCATCCCTGGTACGCCAAGAATGGTAGAATATGAGTATACTAAAAATATTTGAAGAAGAGGACTGGAGCTGGAAGAAAAATCTTTTTACCGAAGTCTTCTGAGACAATTTCGTGAAAATTGATTATCACTTTCTGACTCACAATTTTTAAAAAAAATTTCCAAAATTTTTATCCTAGTTCTCGATCGAAACTGGTCTTCCGACATGCAGGTGCTTGATTGGTAAGTATGACTGCCATACCAAATCAAATGAAAAACACGGTGTATCGTCTGGGAAAAACTTAAACTGTTCCGTTTTAGTAATTGGACAAGGATCTGCTCAATCTCGCTACTATAGCAACCGACATCTTGCGGGTCCAATAAAGATTGGTATATCTTGAAAATTTGATGCACGTTTATTTAATCGCCGCCACACACACACTCACAAAAAAATCAATTAAAGCACCCAGTTGCGCGATTTTAGTTTCTAGGCGCGACAAAAGGAGGAGAACCGAAGCATTTCCGCATTATGGCTCGTGTGTGTGCCGTTCCGTTTGTCCCGCGGCTCTCTCTCCCTCTCTGTTTTTTTTGTTTGCGAAAACTTCTCTCTCTCTCTCTGCCATCACTTGTCTGATGCGGATAACATAGAGGGAGGAGCAGCTTAGAATTGCGGAGGGCAAAATACCTGAAATGTGATCTCTCTCTTATTGAGTCATTGACTGTTGCTGCGAGAGCCTTTTCCCGCGCGCGCCTCCCAACTACCCGTCGACGAGCCGATTTTCTTGTCGGCGGTGCCATTCGCAATACACGTCCCTCTCTCTTCTTGTTCTAGAAACATTCGGATTTTTGATTTTTTGATTTTTCATGGTGGGTCTGAAGGCTTTTTTAGGCCAGACTTTTGGTGGCCAGGTGTATTTTTATTTCCAATTTATCATATTGCTTTTGTCCGACTTGTAGGCAAAGCACCTTTTTAAGCGCCAAGTAATTAAGCTGAAGTTTGGCTGCCTAGGTTTCTAGCCACCAAACAATTTTTTTGTTTTCACACAGCACACTTTTTTAAACACTGTCATAAGTTTTCAAAATTTTTTGAAAAATTTTACACCGAATTTTGAGAACTTTAAGTTTGGTGGCCTAAATGTTTTCAAAATTTTCTATGCCACTGAAACAAAAGTCCTAACTCTAATTGAATTATCTTTGAAACTATGAAAACTACAAGTTCGACTAAATATGGCTTACGGGTCCAATTAAACTCGACTGGGTGGCCTAGAAAACCAATTTCGCTTTTATTTCATTTTCTATGCCACCAATAATCTTGTTCGAACATTACTTTTATTTTAATTAGTGGAGTTTGGAATCTGCCATGGGCTGTAAGATGTTGCTCGCCTCTAGTTTCTATGCCAGGAACCAAAAAGTGGTGTTGGTGGCCGACAAACCCAAACTTGGACAATTGCATTTTCTCGGCCATCATTTTTTTTAAACTAATCGTTGTTGGTTTAGTCTACTGTAAAAAATCAAATGGATAACAACGGGAGCCAAGCTTTGGAGCTGGTGGTAGATTTTGTGCTAGGTCACTAACTGAAATGATTGCAGCTGTAACTATAAAAAATAATTTACACGAGATATATAACATCCAAAATTAGTAGCCTAATTTTAGGATTAGAAACTATTTAAACAATTGGTGTGTGGAATAGAAACTGTATTTTGAAATTGCCACCAATTCCAAATAAGCCTATTTCACTCCTGATTTGAGCTAAAACGCTGAAATTTAGGCCATATTAGAATAGGCTATATTTGAAAAAATGGAATTGGTCTGACCTAGAAAATATTTTTTTGAAATTTCTGCTCCACCAATTTAAATTATAGCATAACTCGTTTCATAGTTGGACGGTGATTGAAATTTTAGACAGATTTTAAAAACAGATTGATCCCTTGAATTTTCTAGGCCACCTCTCCAGAAAAAAATCTGAGAATTGTTTTTATTTCTAATTCAATTTCTTCGGCCGTTTTTCATCTCTCGAGGATCTTATCCCCTTGTCTTACGTCTCCCACCCGCTGCTATTTAGGCGCCTTCATAACTGTGAAAATTCTCACCATTACTTTCCCTATCTCGTTTTTGCCCCCCCCCCCCGGTGTCCTATCCTTGTTCGTACACCTGTTGTTCCATAACATCTGCCAACCAATTTTTTCCAATTTTGCCAATTTTTAGTCAAAAAAGTGCATTGCATCGGCAGGCATGCCTCTATAACTCGTACACACACTTCGCTGAGCATACTGGAAGAGGGAAAAAATCAGGGATTGTTTGGATTCCTGGCGCCTTCTAGGAAAAAAACTCTTCCATTTTTGTAGTGCACATCAAAATGATCAAGCTGATTAATTTTCAAGTTACTCCCATAAATACAACTGAGAAAGTTGCGTTTTAAAGTTTCTAGGCCATCGTGGGATTTCTAGGTAGGTTCCCTTTTTTAAAATAGCAGTCTTGCACTAAAGTTTTGATTAGGCTGTTAAATGCTTTTTGTCAGTACGTTTTTTGGAACGTCGATTTTTACATTCCTCTTTTAGTTATTGATTCCGTTTTTTGCAAATTTTTATTTATTCCATATCTTACAACATTTAGAGGGACTCAAAGTCTTTGATAGCCAAGAATTCACTCTAATGACGTTATGAGCTCCCAGACTATAACCTTTTTCCCTTTTAAAAAATATCTAAATTACAAACATTTAATACAAAAACTTCTCGTTTCGAAACGTTTCGAAATCCTCCATTTAAAAAAATTAGATTAGCATCGGAAAAATTGCGAAAATTTTGAATCTGAGTGTGGATTTTCAATAGGGGGTCGAAACCTCGCAGGAATTTGAGAACAGTACCCTTTCCATCGTCCTTCCCGAAGCCCATTACATCATTAATTTAGCCACCTTTCTAAAGCGGTCCTGGGGGGGGGGACATCTGTAGTTTGTTGCCTATACAGGGACCCCCGCCACAACCACCGCAACTAGAGAAGAAACATCTGCTGCACACAGACAGCTGGCACATGGATGGACAAAACTCCTTAATTTTAGACCGCGCTATTTCATATAATAAAAGTAGAACGGGAGGCAGAAAAGAGGATGACTGCGAAACATCCACCTGCTTGGCTGTCAGCGCATAAACTTTTCGGAAATTTTGGGTCCCACCACGCTTTTTTCGGTAGCAAATTTTGAGATATCTCGATACACCATGATGTCATTTGGTGGAATTTTGGGTTATCATGGCAAATACAAACCTTTAACGTGAGTGCCAAATTGAACTTTTGCAGTCTGAACTTTTGGCCATTACTTAAAAATTTCCATGGGGCTCTCTAAGCCATGTGGTTTCGAATTTTTCCTGAAAATTTAGATTTGGTCATGCACCATGTTGTTTTTTTTTTGGAATAATTGAGGAATTCACGGCTTACTTTTAAAGTAAAAAGTTTCGTGAGATCCATGTGTTTTCATGTTATTCAGTTTGTAAATTATACAGATTATTGACTGAAGGTTAATTTTTAGTTGGGAAAATAAAAATCGCCAAAATCAATAAACAATCGTAATCATTTAGAAGTTGGGAGTTTCCATATAGGCGGTAAAAGGCTTGTCTGCCTTACAATAATACGACCGCCGCTCGCCTCAATCCGCGGCGGAGCAGTGTTCAGTTAGGCACTGAAACCGCGTTCCTGCTTACCATGATGTTCCGTTCTTCACGTCGATACACCATGATAATGGGTTACATTTTGAGCCTTTTCGAAAAATACCATGGTGGAAAATTTCAAGCTGAATTTTAATATTTATTAACCGTATTGTGGGAGATAGCATGCAAATGTCTTTCATCTTGTGTCCCTTCACTCGAACGTCTTCAATTTTCGTCCGAACTTCTCGATGCACCATAATGCTGTTTGGCGATAACTTTAAGAATGGTAGAGATTGCGATGCACCATGACGTTTGTATCGATTATCAGAACAAAAATCACTCCGAGACCCAAATAGTTTCATTCTCGGCACTATATTTTCCAAGTAAATTTGAAAATTGCTTCTCGGAAAAGTTTTTTCACATGCACCTTTAATCTTCTGCTTTGGAAACTATGTAATTTCCGCCCAATACTCTATTTCAAGTTGCTCTCGATGCACCATGATTGTATTTTTTTCAAATTTCTTACTTTTTTTTGATTTTTCCATGAGAGCCAATATCTGTCTTTATAACGGTTCTGTAACGAAATTTTGAAATTCTTGCACGAGATTCTGCTCTCATCTCGACATGATAATTTTAAAATGAAATTTAGCGATTTTTCGGGAAAAAAACTGTTTCGATCAGATTTTCTAGTTATTGGACACTCTGCACCTTGCTTATTGCTGGAAATTACATTTTAAACCGACAACCTTTCAAAAACTGTTTTCGTCGATCTCTATGAGTGCATAATTTTGTTGTAAATAGCTCGGTGGTGGGCCGCAAAAAAACAAAAAAAACAGGTATAAAACGCAAATAAATTTTGTTGTAATGTTGACACCAACAGAATCGGCCTGGAACATACGGTAGATCGGATTTGCAAAAAAACAACGTTTGTTTCGACGTTCCGCCGCTTTTTATGGGAGAAGTAGTATGTACCTTTAAGGGTACCGTAGCCTTGACCCTATGGCCTAAAAGTGAACGGTACTAGTCCCAAAAAAAACAAGATGACCAGTTTCAATCTGTCAACATCTACACATTTCTAAAATCTCATTTAAATTCCACTGTTCGATTTTCGCCTTTCTTCTGTCCCAAAGTACCGTATCCTCATCCTTCTACCACCTTAATTTGCATTTGTTCTTGCTTATTCACTTCTTCCCCTGGACGAAAAATGTTGCACGACAACAACAAAACCCGCCCCCCACCATCTGTTTCTCTGAACCTTCGATCCAACTGTCCCCGCCCCCTTTTTGAAGCCCACTGTCTTTTACTTTTTTTCTTTGGTCGCTGATTATGTCGGTTCGTTTTAGTATTACAGGAATGCACTACAATAAATTCCCTAAACGCGTACCGCGTTGCACAACATATTTGACGTGCAAAATATCTAGTAGCGAAACCTAATCTATAGTTACTCTTGAAATGACTTTTGTAGCATGCCGATTTAACTAAATTATTTATTAACAGATAAAATATTAATAGACACGACAATTCAAAAAAATTCATTTCGTAAATCGAGCCCGTAAAGACAAAAGCGCTACAGTAGTCATTTAAAGAATTACTGTGTTTTCGCGTACGAGTTATTTTGTGCGTCAACATATGTTGCGCAATACGCATTCTTATAATGTACCCGTAGTATATTTTTGTCTCTCTGATTTCCCTCAATTGCAATCTTTTAATTCCAGATTTTTTTGGTGAAATTTCTCCGCTCCATTATCAATTTTTTTTAACCACATAATTATTAACCCCAAAACATCGCAGATTTTCAGGTAAAATGCCAGGGCGTCGTGAAGCGTTAGACCTTTTTCTATGAGTAATGGTGAGCAATTTTTTTGAAGTTTTTTTTTGAAATTTGTAATTTTCCAGAAGGCTTCTGCAAACGGGCATGACACGTGTGAACGACGCCGAAATTTTGGCAACCGTGAGTTCGGCAAATAAGCTAACAGTCTAAGAAACACGAAAAAAAATTTTCTGTTCAAGATTCGTGATTTTCGGATGATTTTTGAACTTTTTGTTCCGACGAGATTAAAGTTCCCACTGAAAACCCTCTCTCTAAAAATCCGCTGCTAAAAAGCCTCAAATGGCCTTGCGAGAATAGACGGAATGTTCAGGGATGACTGGTTTAAAATCGGCGACCTGTTGCCATTCAAACCGAATATCTCATTTCGAGTCCTCCCTTTTTTTTAAGTGGGTCGGATTTGAGATTTAACATACAGAAGAGAATAGGGAGAGACAAAGAGGGACAAGAGGGGAAAAATCTTCTTGGAAACAACCTCGTACCGAAATTACGGAAGTTTTTGCCTCACAGGATCCTTCAATATTGCGTGAGAAAGCTAAAAATCCAATAGTCATTTTTTTCTCCTTTTTTAAAAAAAGGTTTCCTCCCGCGTCAAAAATTGAAAGGATCGGATTTATTGTTACACGCCTGCCTCCTTTCTATTAACCTTGTTCTCGATCGCAACCTCTTTTCTACATTACGTGAAAAAATGCTATTTTTTTTCCTTGTTCAGATTCAATTTGAAAGGTGCTGTGGAAAAAGTTTTTTTTTTGCCCTGAAAAAATAATCGAAATTTCGCGTTTATACTGCTAAAAAATGACGACTCAAAATTTCAAGTAATTCTTTCGAAAAATCGATTTGAAATAGACAAAAATTTTCAATTTTTCATATCTGAAAACACACTTATTTCGATTTTCATTGTTTCCTTGGAAAAAATCTCACAAAAACGCAAATAATTAATTTCCCACTTAATCTGGACTACGATATCCAAGCTCCGCCTCCGCGTATTCCTTGTACGTGACAAACATGGCGGCCCAACACCAACTCAGACATTAAATGAGTGATACCGTACTCTCTCTGTTTTTTCTTTCATTTTTTCGGCGCCGAGAATTTTCAATTTTTGGTGGTTCGTTTGGCGGTATTTTTCGGATTATGGTCGGTTCACACACACACACCAGTTGGTGTTGCCGGTCGTCACCCGACTCGCGCCACACTCTTTGTCCGTGTACTGCTTTGCCATTTGTGCGCGCGAACCGCTGCCCGTCTATCTTATCATATCAGGCGCCTCGTTTTGTCGCTTTTTCTACATTTGCCCTTCCTAGGACAGGGGTACCTGCGGTCGGCTTTTCATCCCAGAGAAAATATGCTTAAAAATTCCGAAAAACCTCTATTTTTCGATTTTAGCATCGATTTTCGCCCAAACATAACCATTTTTCAGAATGAACGAAGAACAAATCGCCTATTGCCAGGGGTTTGGTATTACGAGGAAGACACTGCCTCGTGCTCTCCAGTCAGCGATCCGGAATATTTCGCAGTTTCTCAACTACAGAACGTCGATAGGCGTGCAAAATGTCACAGAGTCCGTGGAAGTACCGACGTCGGCAATAGCATGTCGCCGAGATTGTTGGTCGTCAAGGTATAAATTGCCTGTTTAGTCAAATCTACAGATTCCACAAATTTTCTCGATAGGCTGCAAAATTAAGGCACTGCGCGCCAACTCGCGAACACCTACAAGACACCGGTTGGCGGAGAAGAGCCAATTTTCGTGGTCACCGGACGCCTACGTGAACGAGGCGAAACGAGAGATCGACTGCGCCACCGAGCACTTAACACAGATCCGTGCGTCGAGAAGACATACACAAAGTAGGTGACCGTAGGCAGACGGTTCCTGAGCCGCCTTGCTGTTGTTCCGAGCCCATGCACCTGGACAGATCACGAGCTATAGTTCGTTAATTGTCGGACTCGTCGTCCGAAAGGAGCGACTATGAACAGGACACCCTGACACGTACATCATTACAAGCGCCGAGCCGAGAACGGAGGAGCCCGTTTTTAAGGTATTTTTGTTGGAGAGCATACATAGAGTTTTGGCGCAAAATTCTCATTCATGCTTTATAAACCAAAAACAGAGAAGTTTCTAGTTTCGGCTTAGGAACTACTGAGAATCGGCTTTTCCATGACATATATGTGTGGAGCTGAAAATCTACTTTTGACTGAAAAATTCAAGTTTATGACTAAGAAAAATTAGATAATTAGACCATGCTATTATTTCATAATATTGGTCCAATTTTTCTTGCTTTGCTGAGCAAATTAACAAATTTAACAATCGGCGGGGTTTCTGAAATATTTTTGTAAAAAAACCGATTTAAACTCCAATTTTCCAACCTTATTTTTACATATTAGTACTAGAAAAATTGTATAATGGGGAGAATTCATAAGTTCTAAAATCGGCTGTTTTGTAGCAAAGTTTGTAAATATATCATTCTTAAAGTCTCTAAACGTGATTCTAGAAAACGTGTCTCATCAGGATTTGATTTCTGCGACACACTTCTCTCGAGTTTTACATAGAAGTTGTTCATTACAAATTTCTATTTTTAAGGTCCCCATTACCATTGTCAATCTTTCATTCCGATTATTTGCCTCGTCATAGCCTGCAAGAAGGGGAGCCTAATGCCTAGACAGATGAGACAGAAACACATGTGTGTTTGTAAGTGTCTGGTGTGATATACCCAATTCGTTTCGGCCGTCTCTTGTTTTCTTCCTGACACCGAGTTTCGAGCGATTTTCGAGGTCGTACAGTTATGAATTGGCTGTCACTGCTGTGGCTAACAAACAAAAACAATCAAACTTGTGCGGAATTGATATTCTAAAGAGAATAAAGAGCAACCATGGGTGGCGACTAGCATCGGAAGTGCTTGTGACCTCTTGGTGTGAATTTTAAACGGTTTCCTTCCACAGACTCCGACATGCTAAAAATTCCAGCCGTCGGGAGCCGTTTAGGGTCTACACTGATAGATGATGATTAGAATCTTTTAATTTGGTAGAATTCCCCCCGCGGGACCGCTTAATGTTGCATGTCGTCTTCTTCTTCTTGGCAGCAAAATATCATTGATGATGAGTTATCTCAGTTTGATGCTCAATGACGCCGTGAAACAGCCACCCCACAGTAAATTAGTCGAATTACCGATGGGGCGCCCGGGTTTTTGGAAGAGTCATGCGATTGGGAGTCCACATACACACGCACCATCTCTTTCACTCCATCTAACAGTGTAGTAGGGTGATGAAAAGGGGGGGGATCGATGAAGAGACTCTATTAATTAAATGACCGGGGCGGGGGCCAAATTGCACATACGCTTGGTTTTATTGCACCGTTGGCTCAGTGAGAGCAACATTTTGTGGCAGCACCAGGGGTACTTCAAATACGGGACGAACAAAAGTCGTTGTTGTTTCTATAGGAAGGCTTCCGTTGGACTTTTGAAACCAGATCAGATTAGGGATATGTAATTGACGGTTTTGACCGTATGTGTCCATACACGCGTCGTTGTGTGGTGTGTGGCGACATAAATTAGCGTATGTGCTCCGCATGGCCTTTTTCCTCCTTCCTTACAATGGTAATTATCATCCCCCACTACTCTGGGTCGCCATGGACGAACTGTGAATGTGTTGACAGTGCGGGCCCGAAACTAGTACATGGACATCTTGCCCCGGTGCGGTGCGCTCATCGTTATTCCTCCCAATTTAGTTGTCCGTTTCAAATGTCTCCGGTACCCTATTGGACGAGACAAGGAGGTGATGGATTTGCAGGCGGGGAAGGAATTACATGATGTTTGGGAGATTATGGAAAGGTAGTTTCACCTCGTATTATATGGTTCTACAAAGACCAATTGTCTTTTTTGTTCGTGGCTCAAATGAATAATTGGTACGGAAATATAGAAAAATGTCCGACTAGGTAATAGAATTGTTTCTATGTTTTTAACCAAAAATAGCTCATACTAGTGCACTTGAGTGTTGAATTTTCAAAGGTTTTATTTTCAAATAGAGCATTTTCAATACTTATAAAATCAATTTTCGGTTCAAAAACTTCTAATTTTCTCACCGAAAAAGTTCTCACAAGACAGTGACAGAGGGGTGGTCGCGTGCGAGTCGTTTTGATATCCATCTCGATAATCAGAGAATGTGATCTATGCCTCAATGACACAGTTCCGCGAAGGAGTCCGAGAAAAACGTACAAAAGAAGAATATTGATAGAAATAACATTTATTCAAATCAAAGGATATTAAAAAAAAAGAACATAAACTATTTAACGAATTCACAAAAATTCGGAAGCATATTTCCTATAATGAAAACATCCTAAAAATTCTGAAAATGTGTACTGCACAACATTTTTACGCGCATAATCTCTTGTAGCAAAAACTACATTCGTAATTCATAAAATTGACTAATGTAGCGCTTGTTTAGAGTTATGTGCTCTACGAAATGAATTTATATACTTTATCGATGGAAAAATAATTTTAAGCAGAATATGAGAAAATAATATGAAGAAAAAAGAAATTCGAGTCACGTGCTCTGAGAAATGAATTTAAAAATTTTATCGCTGGAAAAATATTTTTAAGCAGAAGATGAGAAAATAATATGAAGAAACGAAACTTAAGCAATTCATTCGAGATTACGCGCTTAAACCCAGAGCTACAGTAATCTGTGAAAGAATTAGTGTAGTATTCGCTACTAGATATTAAGTGCGTCAAATATGTGCCTATGCGCAATAAACATTTAAGTTTGTGTTTCCGTAATATAAGTTTTTTGCGAGAACTACAAAAATATAACTATTTCTATTCCAGGTGACCGGCCTCCCACATAACGTCGAGGCTGCCGGCAAGGAGATCGAGACGCACATCTTCCGGCGAACCGGAAATCTTCCAGAAACCCGACAAAATGACTGTGCCGGACAGGTGGCCGGTGTCTCGTTGATGGTTCAGAAGCAGCACAGGCTCAACAACAAATGGTCCACGAGGCGGTGTCAGCAACAATCGATATCGAAGAGCATTCGGCAGTAATCCGTTCAATCAGAAGGAGATGTCGTCGCCGCCATTGGAATGGAGAGCTCGGGGATTGGACGCGTTGCTCGCAGCCATCGAGGCGTAGTTCGTTGACTCCGGACTCTTTCCGGTACTGGACTGTCTTCTCGTCCATCGTGGAGGACAATCGGCGAAAAAAGGTCTGCCAACCTACGACTACTGGGGAACCGACAACTCGCTTAATATTATGGAGAACGGTTAGCTTTTTTTTCAACGAATTCATTAATAAGAATTTTAAATGACAAATAAGGATTTTTCCGAAATTCCACTCAGCCGCAAGTACGATGCTCTGTACGCATGGTCGTCGATGGGATTGGAGAAACGCGAGGAATCCCCAACCAATGGTATTTTTGAAGGAATTTTATAAATTACATTTTGATATAAAACAAAAAATGCAATTTTCCTTCAAAGTTCCCGTAAATTTTTGAAAGAAAATTTGATTTTCCGCTAAAAAATTCAAGAAAAAAACAAGTTCGTGTTTTCCACTCGGAACCTGACGGCTTCTTATGTTTTAAATAAAAAATAACGTTTCTAAAACTCATAATGTTTAAAAAATTTCACAGTAAAAAATTATTTTCCCGAAATCTTGAGACCTATCCGTTTTTGAAAATAAAAATTTAGGAGTAAAATCGTAGTTTTCTATATAAAAATTATAATTTTCATTTGAAATTCAATCAAAAAATGTTTAAATAAAATTGGATTGTGTCCGTCGAAATCTATAAAAAGAAAATTTTTTTTGAACAATAAAAGACAACTTGTAATTTTCTTTTGAACTTCGAGGAAAAATATGTTTTTTTTCACCGTTATGCAAAAAATCGATTTTTTAATAACCTCGTTTTTGAAAAAGGTGAAATTCCAATTTCAAGAGGTAAAGTTAATTTATTTATTTTATGAGAAAAACTTGAAATTTAAAGGAAAATTACTGAAATTTACAATTTATCATACATATTTATTTCGACATATCTCGAAATATCAAGTGGTAAATTTTCTCCACAAAAGTGTGATTCTCTTTAAAAACTAGAAAATTTCAATTGTATCTGAAGCAAATCAAATTTTGCAGGCTCATGACCTCCCTCAAAGGAACATCCGCCGGCTTCGGCCTTCTCAGCAATCAGGTCTGGCGGAAACATGAATCTGTGGAGCCCAGGATCGTTGGCTGTTCAGTAACATCTGCCTCGCCGACGTCATCCCGAGACCTGCGATCACCACGATCATACTCTCTTGCCGATCAATGGATAAGCTGTGGATCCATTCATCAATCCATTACTATCGTCTCTCATCTAGCAAAAACCTCAACGGGTTCCAATCTTTCCATTCTTTAAAAGATTCTTTTTCCCATTTTCTACTTTGTTCATCGGTGTACAAGTCCCTCCATTCCCATTTTCTCACCTCTTTACTACATTACTATGCGAACACACAAAAAGTCACCATCATTCTCACAAAATACTAGACAAAAAAAACGAAAAAAATCACATATATTTATATATAACTATTATTATTTGTTATTCATATTTTTGAATTATCGATATTATATATATTTATATATGTAACCCATACTGTCCCCCAATACATATATTCCTACAGTAGGTTTTTTTGGCTGTAACTTTCTCTATTATTTTTTGCACTAAGGACGAACAACTCATGTTTTTAACAAAACGGCAATTATATATATTATGCCTCTTTTCTCTCTATCTCTCACCTAGTGTTTAGCTCCCAATTTTCCCCCTCTCTACTACGCAACTAACGGAGAATTGAGAGGCCTTTTATATTTACAGCATCTTTATAAAACTCGAGTGATCCCCACCCCATCAAATTTATCGTATGTAAACGTTCTGTCGATATATTACATGGTGTATGTGAATGAAGCGTTTCGTGTCGTCTCTCCATATCGACTCTGGTATCCATAGCAACTCCCCGAGCTTTTCGCTCACTCGCGCCCGCCATATACTATACCTTTACTATTATTAAATGCACTCAAATCCTATCCTCCGTCAATTAGCCGATCAATTGTCCGAATTGCCACAATGCTCCATTGCGGGTACTATTAGCACAATAGTTGAATATATTAATTCAAAAATATTTATAGTTTGGAGGTGTCCCATTGTTTCAGATATCCGCGCGACGATAAGTGCCACGTTGGGGGAAACGCCAAAGAAAACGAGTAGGGATTTGCCTAGGTATAGAGGCGACATTTATGGAAAATTTGAAATTTTCTGAAAAAAAAAGGATTTTTGTTCTTTTATCAAAAATGCCTTGTCTTTTCGCCAAAAAAATCAAAATTTTCGACTTAAAAACTTCAAAATTTTTTCAGGATCACACTATACAAAATACAAAATATCTCGTAGCAAAAACTACAGTAATTCTTTAAATGAGTCCTACTGTAGAGCTTGTGTCGATTTACGGGCTCAAGTTTAATATTAGATAAAAATGAGAAGAAAGGTAAAGACACGAAGAAACGAATGATGCCAAAGTGTAATATCGAAAATATTCGAAAATAAATAAATTTCAGAAATAGTCCGTAAATCGACACAAGAGCTTCAGTAGTCATTTAAAGAATTACTGTAGGTTTTCGTTACAAGATATTTTGGTCAAATATATCGTATGTGCAATATGCATTTATTTTGTGTTTCCGGAATAGGTAAAATGTCAGAAAATCAAGGATGGAACCCCGCGTTCTACGGGTATTATGGCCACGGCCACTTTTTCCAAAACTGCAGTGAAAAAGGCGTTGTTATTTCATTTTCTGAAAAAAACATTGAACATTATTATCGAGAATACGATCTGACAAATTTCTCATAATTTATTTTTGATTGTCGCTACCTGTTTAACTTTACTCCGCCCCCAATCTTGTTGCCGGAAGTTTGATATTTTGTTTGTAGCTGTCTTGTCGAAGGACGGGGAGGAGGTCAACAAGGTAGATAAAAAATATATTATGCGAATTTTGTGCGATCGTATTTTTTCGATTATATATATATATATATCTTCATGTAATTCTCATGAAATCTTGAAAAAAAACGCGACACATGGAATTACCCGTTACTCGAGGCCCACTGTTTTATAGTTTGAGCGCGTTGCAATTTTTTGTCGATAACATAGTTTCTATTTAAACAAAAAACATCGTGCGCCCACATTGAAGAAAATGCTACAATTGGTGGCATTAACTTTCTGAAACAAGGATTTACAGAAAGTGTCAGGGCACCATAGCATGATTGGATTGGCTCGAGCAGAATGGATATCCAATATCATCTCAAGTCTTGATAACAAATGTCTGGAAACATGGAGAGTGCAGAAAAACATCATACATGGAAGATGCGGAAAAAATCGATAATCTATTGCGAAGTTAGCTGAAAATCGATATTCGCGATGGCACCGGTGACGAATTTGAACGAAAATCGATAAAATCGATTGGCGCGGGTTCCCGCCGGTTTTCAAAAATTAATAAAACATGGTCGATAAACGAGCACCGTTGAAAATTACACCGTTTAGTGATGAGGAATATCGAAAAACGTCGATGCAGAAACGGATGGAAATGGAGAGGGAACGAGTGAGTTGCGTTAAATAATTTTTTTTTAAAATATTTAACTAAAGGCGACAAGGCGATTTTTAAAAATCGATGTTTAGCGACTTTTATTCAAAAGAATAATTTCAATGCCCTAAATCACTCAAATGGTGATTAAAAAAGTATTTGCGCGCGCGCGTAAAATTGTGCATGCAGCGTATGACCCTATGTGGTAAACCTCCGGGTCCGACACTTTTTGGTGAGGGTTTCGCATCGCTATAAAGATTGCAGATCGCGGCGTGAGCGTTGGCGGCGTTCCGACTTGCATGAGAGTCCTTTCCTACTTTTGCAAAAGAATCGATCGCTCGGATTTTTCAGCTCGCACGTCTATCCAACCAGGCAGGACGAATCCGACGATATCCTCATCGTCTTCCTCCGACTCTTCCATAACGTCATCCGCGTCGTCATCTTCCGAGGAGAAGTTGACTTTTCAATTCGAATATCTTGGGGAAACCCACAGCAGCTGGCGCGGAGAAAATGATAGAACTCAGCCAAATTCCCAACGCATGGGGTCCGTCAAAATCCGCGTTAGTCACTACGTGGCCGTAAGCACTTCTGACCCACTTCCGGCGATTTTCAACGCACATCTTCCGCCGCTCTCCATGGGACGACCACCGCTGACAAAAAGCGCGAAAAGTCGGGAAATCGACGCCATTTTCGGCTCGGATAACGTGGATTATAGAGCGGGGATTTCGAGCAGGATGGCCGTGGCGAAGAAAAAGTCTATGCTCCCTATGGAGAAAAAGAAGGAGGAAGCGAAACCCTCAGAACAGGAGCTAGTGGAGCCGTTGGTCTTTGACTGCCTTATCAGAAGGTAACTTTGTACTTGCACCCTGCAAAAATTCCGAAAAATTATGCACGTGGTCACTGCTAGGTTTTGCATAAGCGAAGCAAAAGCGCCTCATTGAGAATACACGTTTGCGCCAACTCTCGCTATCCATTGGCGTGAGAGACACATATACTACTTTTTCCTCTGAACGTGAAAAACGAAAAGAATACCCGTTTTGCCGTCTGCATCTCTTCTTCCACACGCTATTTTAGCCGTCGAGGACGAGGAACTCTTCCAGGATTTTCTTGGCTTCTCATATTCGTTGTCAAGTTTTGCCTCGTCCGCGAGAAAACGTGAATTTTGAGACGGCCAGCGAGCACGTGATTCTGCAACTCTCCTAAAAATCGATTGTTCCTGTAGCTTATAATCTTTTAGAGGCGCATATTCCGCTTGCGGAGCAAAAGTAAACAAAAAACATGCCGGTCTAGATACAAATCGAAGAATTTCCTGCAAAATCAATAATAAAAAATTTTCAGGCGAATCGATCGGCTTGAAGACTTCGACACCGGTCAACTGTCCGGAGGATCCGATTATTGTTTTTAAAATTTTTTTCTTTTAAAAAATTTCCCGCCTTTGCAATAAATAAATTCTCACCTAGGCTAGAATTTCACTATTCAACTTGAAAAAATATGGTTCGCCCAAACTACGATAAACAAATGTGTGTCGAGCGGGCGAAGCCACTGAGAAAGGAGCAAAATGTACACAAAACCATATTTGAGTGTAATTTTTTCAGAGTTTGGCGCCGATTTTCTGTGAGACATGAGTTTTCTCAATTTATATTTGGTTATTTTTATTTTAGTTCTTACTGGTAAATGTCTGGGTAAGTCCTGATGACTTGTGAAAACGAAAAAAACTCTTTCATTGATGCTAGTGCGATTGCTAGGAAAGCAACTTTCATTCAGTTACCAAGAAAAAGTCCCCATATGGATCTGCGTGGCATAACAACTATCCATCCACGGAGATGCAAATCCGATCTATTGGCAAATAACATGGAAGAGTATAATTTCTCTTCCAAACACGGAAACCTTCCCCTTGGCGGTAGTGCCCACAACCCTGCATGTTTACCAAACTACACAGACAGCGCTTGTCTGCAAGTGGCAAAAAATGGCCGGCGAAATTTTTATGTAAATAATTTTCAAAGTGTTACCCTATTTGCACCTTTTTGGCAAAATTTCCATAAGTAAGAAATTTGATGGAAGAAACGATGAGAGGTTATGCGGGGAGTCTGAAAACGGGGCTGCATGACCTGTATGCGACCTGTTTAGGCCTAAAGCTAGTGACCCCTAGAAATCAAAGTTTCAAAGAGACTTTATTTTTCAGCACTCCAACAAGCTCAAGGCAGAAACTCAACGGTACGACGGATACAACAAGCTGGCGAACAGTGACTGGGCTTCTGCTGGTAGGTTTTTTTGGAAGAGAAATGACGTCACACTGCCCTACTTCTTCAGGAAGTCGGCTGCATGATGCACGCGGTTCCTACTACTCAGACGGCGCGTATATTCAGTGAATAACTCAGTCCTCCTGTCTCCGATATACTATTGGTTTAAAGGAGAGTCCGGTATTCCTTATACAAGAGGATGCCCCACTTGTTATTGGCATTTTTCAGTTTGTATTTTTTTAATACTAGTAGCTGAGCCATTTGTAGGTCATCAAGTAGTTGCTTAATAATGCAATCAAATGGAGTATCCTGTCCACTAGAGACACTTAAAATTCAAGATACCCCTATGTGATAATGTATTTGAAAATGCGAGTACTGGGGAAAACTACAATCCCATTTTACCATAGTGCAGACAAAGCAACTGGAAATTTTACCTCGAGAACAAACCGTCAATGAACGGACTTCATGGATTGATGGATCATTCATCTATGGTACCGCCCAGTCATGGGGGTCTAAGTTTTAGGACGGTTAGCTCAGGGTGCACCTGGATATCGACCACTTAACAACCCACATATTCCATTGAATATCCCCGCTCTGCCACAAGTACATCGATTGATCAGAGTCCTAAGATAGATTATTTAGTGTGTTCATTGTTCTATAGAAAAGCTATAAATAATTTGTAAAATTGAAGTGTTGGGAGACTCGCGTGTGAATGCAACAGCATCCTGGTCTTCTTTCATTTGGTCTGATCCTCTTCCGTGATTGGCATAACTACGATGCAAATCAAATCTATCGAGAACATCCTGACTGGACAGACGAGCAAATAGGCAGCACGGCGCTGGGATTGGTCATCTATGCAGAAGATTATTTGCTTTGTTCCAGGACCTCTAGGTTACTCATAGTGCATCATCTAATAGCTTAAACTCAGTGATTTCTGTTAAGGTGAAGTCGTTCGTTTGTCAAACTACACCAAAGGAATACATGCCACACATGCCACCTGGAATCTCGCTTTTGGAACACCGCCTTCAGGTTCCCTCACTCAATTGTGCCACCAGCAATAGTGGCTGCTGAGAAAACGAGTAAATAAATGTGAACCGGACGGAAGATGGTGGATATCCTGCATTGAGTGCCAGCGAATTGGTGGTGGAATGCACAGGATATTGGGAAGGAGTAGACAGTGTGGATGAAAACCTTATTCCTGGTTAGTTAATACTTGAGTGGTTATACTTTTGATAAAGATTGTTCAGGATGGCAAGCCAGATAGCTGAATGAGAAGATAACATAGTCGCAGATCTTCGTGATTACAGGACCAATGCATTTCTCTCGTTTGGATGTTGTTGCTTCATCAATAATGAGAGGAAGGGACAATGGAGTACCCCCGTATAATGAATTGAGAAGAACCTTCGGACCTGCACCAAAGGCATGGGAGACAATGAATGAAGATTTCTACAAGAAGCATACTGCGTGGAAAAGTTGAAAGAGTTTTGTGGATGGAGGCAATATTGAAACTTATTATATCTGGATGCTTATGTTGGAGGGCAAGGGTCTTTTATAAAAGTTAGAGAGATCCTCCAATATACCCTCATAACATATTGTATAAGTTTAATTCATCAATAATTCAGCTTGGACCATTTAGAATGCTGGAAGGAGGTGAAAATGGCCCTGAGATGTTCAAAGAAATCATAAAGGATGTTGGCGCACCCGTATTCGAGATGGAGGAGATCGATTCTGGTTTGAGAATAAACTAAATAGATTATTCACTAAGAAGTTCAAATGAAAGTTCATAGTATTACACTTCGTATATTATCAAAGCATTGCACAACCGATGTCGACGATGCTTCAGAAGGATGTGAGTTATAGTAAAACACCCGTTGGTTATGATCGCGTAGTTAATAGAATGTTTCATTCCAGTCATGGATCTTGAAATTTTGTCATGATTCTGTTATATAACAATATATGTATGTATTATATAATACTCATGTCTCAATATGGCATTTAATTTCCAGGTATTTTTCTTCAAAGAAGGTGATCCACGCCCCCGGCTTCCTAGTGAATACCATTGGACTTGAGTGCTCCCCAAGACTTATTCAATTCACCTACTGGGATGATAACGAGACTACTTATATCTACAGTCTAGGTTTGGCGTATATTCCTTTTAGTCAGTCTTTATTTCAATCTGATATATACTACCGATAGAGACTCAGCGATTATAGAGTTGATCAAGCTAAGAACTTTCAGTTTGCTATAATATCTCGCGATCATAATATGGTTGAACGACGTATCCGAATAGGTCATAACAGTGCTTGTGACAGCTTGACTACTGACTTGTCAACACAAAGTCCCAAAGTTAATGTCTACAAAGTGAATGGTATTTTTTCATACTTGATTTTGATTTAAATTATGTCGTGAATCTGCAGCTTTGGAATGGCTTCAAAGTACATACGGTCAGCAAGTTCGGATAGAAAGCGAATACCACTTGACAGTGTGCACAAGAAGGTTGTGCGGAATCCTTCGAAAAAAGGCTTCGTTTTGGAACTGGACAAAAGATTGAGGTATGCCACTCTATACCGAATCCATCAGCAATGCACGGACCATTTGTATTTTGTCTCAAAAGAATAATCTTCATTTGGTGATAAGATTGTCGTCTGATAGAGATTTTTCTAAATTTCTGATCACATTAGACAGGGGCTAGTGGAATGCAGGGGTTATCATAAAGGCTGACGAGACTTCTGTGAGTTTACTTCAAGAAATACGTCGAATCTGGAAATTATTTCAGATTCTCTTGTCCCAAGCAATCACAATAGAACACCGGCAAGACCGACTGTACCTGTTCTTCCGTGAAGCCTACGCAAAAGCATTCAATGATAGTGAACTTGCCAAGATTTGACTCGGAAACTTCATCTTTGGCTCATCGATGATGATTTAGTAAATGAGACAATATCTCGTCAGGAATTGGCAAGTGCAATGGGAATGAAAGCATAAATAATAAATACTTGAGTTTGTTGTGTGAACAGAATGTTCGCGATTGCAAAATAATTAGGATTCGCTCAGTTTCAATGAGTTTTTGACAGTATTCTTGATGGAGTTTTTTAATGGTGGGTTTATTGTGATTTACTAAAGTTCTGATCACAAATACTACACGTGAGTTCCAGTCTGTTTACACTAGGTTCGGTAAATATGTATAATGTTATAGGGTGACTGTTACTGAAGCGCCTTAGTAGTCTTCTCTTCTTTGAATGGCAACAAACAGGCTCCGTCATTAACACATTTAAGCTGCATTTCTCTGCTAAAAGTAACGGCTTAATCGAAGTGCGATTTAAACATTCGGGTCTATAATCGTCTTTTAGTATATTGTCGCGCCTACTAAGGCTCGCTTTAATAATCAGTTTTAAACGCGAATTTGATGGTGTTAAATACGATTTTAATTTGGGAATTGTTCACAATTAGATGCTATCTTGACTAATAATAAATAAATACAGACACAAAAACCTTTTACTACATGGACAAAAATCATCCGAATCTACCCAAATCGGCATTAGGTTAATGTCTTTGATTAATCACCTTCTTTAATTTGCAGCTCCTCAAAAGCAAAAACTGCACAGTCTATTCAAAATGAGTGATTTGGAGGGAAAGAACAAGGTTCTCCGAATGGATCTCGCAGAACTGGTCAAGTCCCTCAATCATACCGCCGGAGTTCACATTACCTAGAAAGTGTGCAGCTTCGATTAACTTTCAATGACGTGCTGCACAGGTGCAGGTATACATCCCTGTGTAGTATGCCAAGTATTAAGTTTCAGGAGTAAGTTCTCGACGATGCGGAGTACTTGACTTGTAATAATTTCGACGCATTGTTCTCGACGGAGATCTCTGACGTCCCGATCGGTCTGGTCCATTTAATAGATTATTACTCACATTTATCAAGTAGTATGGTGTTGAATTCAAATTCGCAAGTAAATACAACTTCAGGCCATCATGCCACACCTCATTCCCAATAGTGACCGCTCTACTCCTGCTCCACTTTCTCTGATTCAGAGAATTTGTGCATTCAAAGACTGGAAACCTATTCGACTACACGTCTTCATCATCGTCTGCTTTGTCGCCATTCACATTGTCCTTTTTTTCGAACTTTTCTGGCGTTTACTGTTTAGTTCGGTTTTCAAAAGCAATCAATTAAGATTCCTCCCTAAACGAAGATCTAGACCTCGGTCGGGTGTGGGTGCCGGGATCGCTATCACTCTCTCTTCTATTGCGGGAGCCTTGTCATTTAGCATGGCGTTGATATTGCGCTTACAGTGAAATATTATAACACTGCTTCGAGAGAGACAGTATTGCGCAGTATATTCCATTTGACTCGGCTTCGCGTTCCATAAGGTAAGAGCCTCTCTCTTGGCCTAGCGCTGTAGGTTAATTAAAACAATTACTCCAACTCGTAATTTCAGAGCGTCGCATTATTCACCCTATTCTTGTCTACCCTTCACACCATCGGCCATTGTGTAAACTTTTATGACGTTGGAACTCAAAGCGACCGTGGACTTGCTTTTCTCTTCCAGGAACAGCAACATTTTACGGGTAGCCGCACCTACACGACTCGGTTGGCAGATCTCTCAGTAGATTGAACGTTGGCTTGCTTTCAGCTCTGACGTCGCGCCTACCCTAAGCTGGTTCTATGGAACAATTACTGGGTTGGCGGGAATGGGATTAGTTATTATTTGGTTATGAGTATCATTTATGTGTTCGCATGGCCAAAGATCACTAAGCATATCACTCGTTTTCTCCGGCTGACTCATCTTGTGAATGTTGGGTTTTATGCACTCACGATCTTCACGGACTTCCTTTTTGGGGTAAGGCTTAATTTAATTTGATTCATTGCGCCTACGCTCTTTTTACGCTCTTGACGTCAATATTTGGTACGTCTCCCAAATTTGGCACGTTGGGACTCATTGTCCTTTCTGTAATCGAACGTATAATTGGGTTGATGCAATAACCCATTACAAGTCGTTTGATATAGCCCATGGAGAAATCCATCAGATATTATATACATCGAGTACCGTCGTGGCCAGGAGAATTTGAATATAAATCAGGACAATGGATTACAGTATCACCACCCTCTATATCATGTACCTTTAATGAATCTCACGCATTCTCGATTGTCGCCTCAATTCCACAGGATGAGAATATGAGGTTGTATATAAAAGCAGTTGGACCTTATCCCCCGGACATGGAAGTAGAGAAGTGGATTGATAAGCTCTTGAATACAGGGTCACCATTCCCATTGGTAATTCAGATGAAAGGACCATATGGTGACGGTAATCAGGAATAGATGAATTATGAAGTTGCAATAATGGTTGGAGCAGGAATCGGAGTGAGTCCATATGCATCCACGCTTGTTAGTACCAAACACATCAAGTGACTCGTTACAGAGTGATCGATGTCGTAAATATTTCCTGTGTGTTCGAGTCACAAGAACTTTGAATGGTTTGTGGAAATGCTGTCCTGAAAAATGACTATTGAGAATCATTTTAGCAAAGCCTCCTGGGCCCGAGACACACATTATTCGTCACTCAGATGTTCCATAAGTTTTATTTAAGCGGAACTACTATGCTTGAGTTTTTTATGCGTTTTTGGTTTTTACATGTATAACTCGGCTAAACCTAATGGAGAAAAAGGTTCCTTAACTAATAAAATGTTGCTCAGCTAACTATTTCTATGCAATAAAATATGTTTCAAAGTATCATCTCACAAGTCCAAATTTGATTATTTTTCTTAAACCGAGTATATTTCAAGTCCGAAATCTAGTTTTCTTGAAAAAATTTGGTATATTTTTTGCACATAATCATTTTATAAAGTGCTCTGCAAATCAGAAATAGTTCGAACAGTCTTTCATAGTTAGTGTGACATTTATTGGAACTTAAAAGAAAAAATTACGCGACATAGAAACGCTCGATTATCTGAAAAACCAATGGATTTTGATTCTAGTTAATTTATTTTCAAAAACCGATATAAACATATTTTGTGATAATTGTAAACTAAAAACTATACCTGAATATTTTTATATTTATGTGGTTTTTGATTTCAGGATTCAATGGTAAAATACTACCCTAACGGCTTACCCAAGTCTCAGAAAATTGTAGTTACTCTCAACAAATTAATACATATCATTTCTTATATGAAGTACGTTTGCGAGAAGCACTTCCGTGCCACCAACACAGGCATATCAATGTTCACTGGCCTACACGGTAAGAATCAATTCGGACGGCCCTTCAAAACTTTCTTCCAATGATTTATTCAGAGTGAGATAAGGAGGTTAGTTTCATGGTTTTAACCTCTAAATAAAGCAAATTTGCAGCAATCCGAAATTGGAGTGTTCAGTTGTGGACCTGTATACTTAAATGACAGTATAGCTGAAGGATGTGCATGCCAATCGACAACGAGATGCTCCATTTGCACTTTGAACCTTTCTAATCTTCCCTGTTAGATTTACTATGACAAAAAAAAGATCATGAATGACAAAACATAGAAAAAAAACCTGAAATAAAGATTTCACATTTGTCCAGGTAGTATATATCCCCAATACAAACATTTTGATACGGTCTCGAAACTTCCCCATTCCCAAATAATCATCAGACATTGTAATTAGGCAAAAAACCAGACCCCTCGGCTCCTCCCTCACCACAAATAAAAGCAATTCCCCCATTTCCCCCCAGTTCATTCACCAACAATGAGTTTATGACGTTCGTGTCATACACTTCGTTTTCTTTACGTGTTCATTTCTCCGTTCTCTTCCTTCTCGTCGCTTTTATTGTGATCTATGACATTTTCGATGAAATTCGAGAATTTCAAGAAGTAATCGAAAAAGATGCCAGGAAGTTTGAGGTAAGGCAATATGTGGTGCAGCAATAATATCCGCATTTTTCGTAGATCATACCGTTATGGGACAGTCTGACACCACGTGATAAAATAGTATACGAATGTAAAGCAAGGTTGAAACGAAAATGAAATTTCGTTTTCGAAAACGAAAACTTTTCGTTTTAAACGCGAAAGACTTAGAAAACGAAAACGAAAATATCAGTTTTGTCCTATTTAATTGGTAAAATATAGTTTTAGGTACATGAATTATTAGGTCCATTTTCGAATCAATAATAAACAAACAATAGTTTTATTACAAACAGTAAAAATAAAATAAAGCTAAAGAACAATAACAATCACACTTGCTGAACAACTCTTCCATTTATCCAAATTTAAAGCCACTTTTTGATTTAGCGTAAGAACACAGACTTGCTCAACGACTCTACGTAGACTTATTCCAGCTTTGTAGAAACGTGAGCCGCCAGCTCCTGAGAAAACTCGTTCCGATTCAGCAGATGAAGCTGGGGTTGTCAGATATCTGTTCGCTATATGAGAAAGCAATGGCAACTTAGATCGATTGAGCGTATTTTGAAAAAAGAGCGGGGTCTGATTTTCTATTGTTGTGGGTATCGGAGAAAACCAACTTCGGCACTAGCACCGAGCATGGAATCTACAGGCGCTTTGTATTCTTTTTCTGATCTTGGAATGCTTTTTCTCGTAAGCTTCAAACAGGAACTTCGTTATTCCCACTAGAGTTTCATTTTCTGGCTCATCGACTGCTTCTTCTCTTCTTTTAATAATCCTTGCGCTAAGCTCAAAACGACCAAGCTCTTTTCCGTCTATTTTCTTTTGTATCGTGGGTCCCAATGTTTGATGCAACAATCACCAGTTTGAATGTCACCAGTCGGTGCCCGCGTCGTAGGTGCGGTCAATGGCTGGTATGTATATAATATATATTAGATGGAAACTATAACATTGAAAAAAAAAAGCAAACATTGAAACACAATAGAAAATCAAAATATGGGCTCTTCTTGAATAAAAATCAGAATTACGAATTGTTCACTGGGGCTTATTTCTTGTACAAAATAATGATTTTGACCAGGCTCAAAAAAAATACGTTGTGCACAGAGAGAGGTGATGTTCCTTTTTTCGAAAATTCGAAAACGAAAACGAACAAAACATGACAGAAACCCGAAAATAACGAACAAACGAAAATTCGAAAACGACAAAGTGACAAGCCATTCCTGATTACAAGGTCGGTATTTCATAAATATTGTAGAGAAAGGTTGCTACTAGCGATGATTCCAAAAAAATTTAGATTCATCAGAGATGTACACCCAAATACCCAAGGCATCGGCCCTAATTATTGATTAGACACAACCGCGCTTCTTACTTCCAACAAGCTTTTCCTATTTTTCCGGTTCTACTTCACCGCCGCCTCACGTTCAATTGCCGGTTTCGACAAGCGGAGCCGATTCGGAGGAGCTGTTTCTTTTTAGTTGTATATACATCTTTTTAAAATTAAAAAGTCAGTGTTGTTGTTACCCATAAAACAGTGAATGAAAAAAAAAGAAGTCTAGACAGATCAAATGTAAAACTGGCACAGAATACTCAAAGAAGCATAAAAAATGTATTTTAATAATGGATGATATAGGGAAGGTTAGAACGTTTCAAAGCGTGTGGTGCAAATGAAAGAGCATCTCGTTGTCGGTTGGCAACTGCACATCCTTCAGCTATACTTTCTTACACGTCGACAACTGAACACTGGCCCGATTTTGGATTGCTGCACATTTGCTTTATTTCGAGGTTAAAAAGCATTTAACTAATCTCCTTATGTTCACTCTGAATAAATTGGAAGAAAGCTTTGAAGTTGGGCCGTCCGAAATGGTTATTAGCGTGAATACCAGTAAACATTGAAATTCCTGAGTTGGTGGCACGGAAGTGCTAACCTCTGGACGAATGTACTGCAAGTAAGAGGTTCAAAAGTTTAACAGCTTCAGACCTCCCGCTGATGCCACTACGTTTAAATGCGTCCGCTTTAATCAGTTTATAACCATAACCTGACGTTTGATTTTGAGAATTATCTTCAATAAACTCACAAGCATAGTAGTTCTCAAATCACTTGTGGACCGTCTGATTGACAAAGATATGTGTCTGCCATAGTTCCCGACCTTTCGTGGTCTCACGTTCTTTGAGCACATCCCCCCACAATCCAAGGTTTGCATAGTCCTTGTGAGCTTTCGAGTCCACACCCATAGGAAATATACTTTACGGCCACGTACTCTGTGAAATGAGTCACTTGATGTTCGTTGTACAGATCAACAACGATGCATATGGAGTCACTCCGATTCCTGCTTCAACCATTATTGCAACTTCATAATCCATCCATTCTAGGTTACCATCACCATATGGTCCTTTCTTATGGATTAATGGAAATGGCGATCCTGTGTTCAATTATCTTATCAATTCGCTTCTCAACTTCCATGTCGATGGTCCAACTGCTTTTATATACAACTTCATATCATCCTGTGGACTTGAGTGGGCAATCGCCAGAATGCGTGAGCTTTAAAGGTATTTGCCGTGATATTTATGGTGATATAGGGATACAGTATGACCCATTGTCCTGATTTATATTTAAACTCTCTTGGACGACGGTACTATTCATATCAAATATCTCATGGAAGGATTTCTGCGTTTACAATTTCTAAGTTTTTGTAATATTGCATCAAACCAATTATGCGATCGATTACAAATAAAACGATTGAGAGGGACGAACACCCACGTAGTAGCAAATTTGGGAGACTGCAGTTGTCAACAAATATTCGAAGAAACTTCTTGAACTGAACAGTGGCAAAACATCCAACAACTTTGGAAGCCCATGAAGAAGAGTACGTGCGTAAAAGGCAATATTGAAGATGTGATCCCTTCAGAACCGGAATGCGTGATAAGCTCTCTTAATGAGACATGGGAACGCGAGATCATAAATGATGCACATGACAGCGACCAATGCAATTCCTGTCAGACCTGTAATTGTGCTGAAGAACCAGTAAATGATTGAAGGAAGGAAGTTGGATCTGAAAGTTATTTGATGAAAGTTGTTGTCAGTCTTGAGAGAGTTTGTTAATGCGTATTCTAGTAAGATTGAATGCAAAAATGAATTCAAGTAAAGTATTACCCAAAGAATGCTTCCTGAAAGAGACAAGCAAGACCTTGGGCTTGACTTTGAGTTCCAACGTGATAGAGATTGACACAATGTCCAACGGTGTGAAGAGTAGCCCAGAAAGCCGCGAAAGAGCGCAACGATCTAGAAATGTTCAGTTATTATAGAGTTTTTGATACTGGCGGTCATAATAAACAATACTTTGTCCAAATAGTATTTCCCATTGTTTAATGTCATAGTTTATTAGGTGTATATTCAAAAATCTGCCACCATCCTTCAGAACACTTATGTAAAGTCGACTTAAAAACATCTGAGTTTTTTGAGCAACAAGAGACCCACACTCGTTCTAAATAGAAATATATCTGGAGCACAGGAAAATCTTTAAACTTAGGAGACACTTTTTTAGTAAACAGAACACTACACACAAGCAACACTGATGTAATGTTACCTTATCCTCACTTCTATTCATCATTTATTTTGCCTTTTAGACATCGATTTTTGTGTTTTGCTTCTTCTCCAATGTAGCCATTATTTTTTTTCTCATCCCTTTTTATTTTTGTTCCATTTTTATTTATGTAACGTATGGTTTGTATATTTTAATGTGAGTTTTTTTTCCGTAGCTCACGATATCTTACTATCGTAATAAATTTAAAAAAATTTTATCAAACACTTACGAAGTTTAGGCCGCTATATCATAAGTTCAAACATCTGGCTGAGACACCATGTTCGATGAAAAGATCTTTCCTTTCAGGCGTTGTATTCTATTTTAAAAAGTCTTTTCAAAACATTGTGTACGTACAGTACAGATATCCTACTTGCATGAAACCTCCGCATTACTGTACAGATAATAAAATAACACGTTTTCCCTTATATCTGAACATGCTAAATATTTTTAAAAACAACTGCTCATTTGACGGATAAAATTTACTAATGCCATCCAAGAATAATATTTAAAAAACATGTGTTACACGCTGCCCTAACGTTTCTCACCTTGTGGTTCCAACGCAATAGCCGCAAATAGTCTGGAAAATGGAAAATACTGCGTACAATGACTGTCTCTCGAAGCAGTGTGATTATGTTTCCTACAAACTGTCAGCAATATCAACGCCATGCATTATGAAATGGCTCCCGCGGCACCACGAGTAATAGCGATTCCAGCTCCCATTACTCGTCGGTGATCCATGCGCCATGTATAATCTGAAAACTAAATTAACATGAGCTCCCCATTATATGAACACGCCAAAACCGTTCGAAGAAAAGAACAAGATTGATGGCAACAAAGCAGAAGACAATGACAAACGTGTGCGATAGGTCTCCAAGAACGCTGAAACCTTGTGGATCAAAGTTAGCGGTGCTGAACTGTTGAGGTGCCGGATCGATCCACGACGGCAAATGAGTTCAGAGAAGATGTTCTAAAAGTTATAATTGTTATACGGTAAGAGGCCTCCTGAATACTCACTCTCCAATACTTGGCTGATAGACATGTTCTCTCGATTGAACGTCAGTCCAACTTGCTTGTCAGGTATATCCGAGAAAGCAATCCGAGCAGAAATCATCGTAAGTCAGGTACCGGTTGGCATCATTGCTCACTCCTGCATAGTTCAGCACTTCATTGAATAATCGGGATGAAGCTGCACACATTCAGTAATGACTCCAGCGGCGACTTTGATTGTGGGACCTGACGAGTTCCGCGAGAACCTTTCGGAGTACCTTGTTCTTTCCCTCCAACACACATTTTGACTAGAGTTTTTTTGCTCTTGAGATCTGAAAATTAAAGTAGGTGGTGCATAACATTTTTTAAAGGCAGTTTTGGTTTTTCTAATGTTCATTAAAAGAAAATCTACAATTGACTAATTTCTCGACACTTCGGTGCCATATTAGTTTTGACCTCCCTGTCACACGAGAACTTTCTACAGTGCTCTCGCAAATACTATCGGGCTCCCCCGAATAAATTCAGATTCATAAAGAATAAATAACCTTTAGAACTTTACTATGTGCTCTCGAAATATTGCCGACCATAGGACACCGAGTTTCCCGGCTAATGAACCAACAATGTTAATCCAGCGGTCGCTAACCGCCTAGTCCGTTTCAAGTATCTGGAAATAAATTTCTTTTGGAGACTTCGGCGTTCTCTTGTTGTAACCAAGGTCTAACCTTTTATATGTAGTTTTGTACGTACAAAATCAAAGACAGTTCAAAACAACTTTACCGCTACTGCTGTTACACGTAATTAAGCTGTATTAAGTATATATTCAATTAGAACTTGCAAAGTTAATGGGAAACACGTCATGCCGGAACATTCTAAAACGTAGTCTTTGTATCACGACAAATTTATGCTGAAATAGTCACCATTACTCTCTCAAGACTGTCCCCCAATTGCATTGAAACTGAGCCACGGCTCATTATGTTTTTGCTGCATTGGTCATCGCGAACATTCCCTTCTCAAACTCATTATTCGCTTTCATTCCCAACTTGCCAGTTCCTCGCGAGATATTGTCTTAATATATCATCATTTTCCGTGATGAGTCAAATGAAGGTTCCAAATCTTGAAGTGCACTATCATTGAATTCTTCCCATTTGCGTAGGCTTTCGCGCACGGATGAACAGGACCAGTCGGTTGACGGCGTTTCTTTTGTGATTGCTTGGGATAAGAGATTCTGAAATAATTTCGAGACTTCAACGTATTTCTTGAAGTAAACTGACAGAATTCTCGTCATTCTTTAATGACCTCTGCATTGATTCCACTAGCCGCCTGTCTAATTTGATCCAAAAATATAGATAAATCTCTTGCTATCAGACGACAATCTTATGACCAAAGCACTGATGATTATTCGAGACAGAAGTACAAATAGTCCGTGCATTGCTGATGGATTCGGCACAGTGTGGAATGTAACTGAATCTTCTGTCCAGTAAAACGAATTTTTCGGATTACACCGCGTGGCTTCTTAACTGCCAAGGTGGTGTTTTCTATTCGGCTCTATCCTGACATGTCGTATATACTCTTCTTGAAGCCATTCCAAAGCATTTACACCATAAATATCTCCCTTCGCGCCACAATCATCATAGTTTTGCAAAGTAGTTAGGCTGTCACAAGCACTGTTGTGGCCAATAGCAATGCGTCGATTAACCAAGTATCGGCCAATTCCATAGCAAACTGAAAGCATTTTGGTTTGTATGGAACTAGATGGAATAGCTCACTTAATGGCACAATGCTAATCCAATTAGGGCGAAAACGTAAGTGGTGATCAGTCCAATAAGTTGATTGCATAAATGGCACACATGGTTCAAGTCCAGTTGTCTGTTCACTTGGAATGGTTGCGGGGGTAACCTTCCTTGAAGAAGTATAGCTGGAGTGATAAATAAATTGCAATGCGGAATTCAAAAGAACATAATAATAAACCATTAAATTTGGAAAGTACTATTACTTACATCCTTCTTAATGTCTCATCGATATTGGTGGTTGCTTTGATAATATCTCGAAGTGAAATACTATGAATTATTTGAACGGATTCTTCATCAGTGAGTATTATTCTCAAACCTTTAGAATCTATCTCCATCACGAATAGGGGTCAATTGATCCTTTATGATTCTTTGAACAACTCTCCAGGCCCTATTTTCACCTCCTTCCAGCATTCTAAAATAATGACGTTTTATTGATTCACGTAATCCAATATATGTGCACTGAGAAAGAAACAAGTATGCGTAATTTATTCTGCCTGATTTGCAAAACATACTACCTTGCATGGGTAACTGAAAGAATTAAGGAATTGCTATACTATAAAACTGAGGTGACATACAACGTCCCGCTGAGAGTCTAGCCTGCTACAAATTATAGAGTATGACCTAAAGAAGCCGTTAGAAGTTACTCGTGAGAACTTTTTAACCCTTGAGAAGACTTTAGCGAATTCTATTCAATCCACTTATACCAATCAGTTATAAACGAATTGATTTTCATTGTTTTTGCTTGAAACTCTTCGAATTCACCGCATTTTAAGTTACGAATTCTACTTTAAATCCAAAACTAACCCTCCTAATAAGCATCCAAATATAAAATAGTGCCTCCATGCAACTCTTCGTTCAACTTCTCCACCTTTGCAGTATGCTTCTTGTAAAAGTCTTCATTCATTGTATCCCATGTCATTGGCGCAAGTTCGAATGTTCAATTCATTATACGGTGGTACCCCATTGTCCCATCCTCTCATTATTGATGAAGCAACAACATCCAAACGAGAGAATTGCGTTGGACCGAAGAATCACGAAGATCTTCAAAAATGACTACTATGTTATCATCTCGTTCAGGTATCTCAAGGCTTGCCATTCTAATCTGTAGTTACAATACCTCTATTATATAACCACTGCAAGCCTGAACTAACCACGAATAATCTCATCCACACTGAGCGTTATTCCTTTACAGGATACCTGCGCATTCCACCAATTCTGGGAGAATCTTGACCAATGCAGGATCTCCACCAACTTCCGTCCGGAATTCACATTTATTTTCCTCGTTTTCTCAGAAGCACTGCTGTGGCACAATTGAGTGAGGGAACCTGAAGGCGGCAGCTCCAAAATCATGCGAGATTCCTGGTGGACCATGTGTTTAAGCATGTGTTTGGTGTAGTTTGACAAACGAACGTCTTTAAAAGAAACACTGAGTTTAAGGTATTATAACATAGTTGATTAACCTAACAGCCCTCTCCGAAGTCATATGCAATAATCTTCTGCATAGATGCAATCACCAAATGACGTGCTGCCTGGAAGATTTGTTGGTCTGTCCAGTCAGGATGTTCTCGATGGATTTGATTTGCATTGCCAACGGAAGTGGAGCAGACCAAAAGAAGACCTGGATTCTCATTCACACGCGAGTCTCCCAACACTTCAAGTTTTAAATATTTATACTTTTATAAAACTCTGAACTCACTAAATAATCTATCTGGACTCATCAATCGATGTACTGGTGGCGGAGCGGGGTTATTCAATTGGAATATGTGGGTTGTTAAGTGGTGGATTATCCAGGTACACCTTCAGCCACCGCCCTTGTTTGAAGGATCTTAATGAGGACACCCATGGCTGGGTGGTACCATAGATGAATGATCCATCAATCCATGAAGTCCGTTCATCGATTTGTTCTCGAGGTGAGTTGAGTAATCCCATTTCCAGTTGCTTTATCGTATTTGGCACGTGTGAATGGGATTTCTGTCTATCCCTCACATTCTTTATCAAATGCATTATCACATAGGGGTACTTGTCTGAATTTTAACTGTCTCTAGTGGACAGGATACTCCATTTGATTGCATTATTTCATAAGCAACTACTTAGGACCTATAATTCTTATTACTAATTTTTAGAGGGCGATAAAAACCAACTGAAAAATGCCAAAGATATCGTGCATCCTCTTGTATTAGGTCTACCGGACTAACTCCTTTGAATAGTATATCGGAGAGTTCACGGGCGGACGCAAGTGAGTAATTCACTGAATATACACCGTCTGAGTAGTAGGAACGTGCATCTCTATGCAGCCGACTTCCTGAAGGAGTAGGGTAACGTCATACGTCTTCTCTTCCGAAAAAACCTACCAGCAGACCCCCATTCAATCCTCGCCAGATTGTTGTTCCATCAGTCGTATCTTTGAATTTCCTGATTTTGTTGGATTCCTGAAAAGATAAACGAGTTTTTTATTTCCAGGCCACCAAAATCTATATGACGGCCTTTTAGTTCCTTATTGAAATCTCTAGATCGCACAGTCACACATGCTCCCTTCACTACATTTTCACGATTCGTGCATTTTCTCACTGATCGCGCAAATTTCCGGTCAGTAGCGGAGCAGAGCAAACATTTGCCTAGCCCCTCCACCAGAAACAATTATTTTCGTATCAATTTCGCACCTTTATTCCGTTTGTTTGCCTCTTTTTTGTACATTTTATCCTTTTTCTAGCGACAATTGACGGCAAGGTCAGTACAACAGGAAATTGTTCCTGTCGTGAATTTCAGGAATTTTTCCAAAATTGGTTGGGAAACTACCACTGTGTTGAAAATTCGAAAGATACACATTTTGTTATTTAGGTGTAAACATGAACACTAGGTAATCTATGTGTTATGAAAAAGATAGAACACAGACACCGGGTGGCATACAGAGCTTATCAGTAAACAACTATCAGTGCTTTTGAAATTTTGGAGGGGCAGAAATAAATGTTGCGGACAAATTTTGTTTGGGATTTGAAGTTATGAGAAATACGCAATTTGAATTTTTGAACATTTTTTTGTAATTTTTATCCCATTCACGCTTTGTAATCTAACATTTTGAGAATCTAACCGGCAGAGAAAATAGTACAGACACGTTCAATTTCTTCCAAAAATTATCAATATAGGCCACTTGGTGTCCATCTTCCTTAACTGTTTGCTATAATTCCTACCTCTCTTTAAAAGAAATCAGCTACAATTTGAACAGATCTTGGTCAATACATTTTCAAAGATCGGCTCGATCCCTCTTAAACATTTAAGCTAGCAGGTCCGCTCTGTTGACAAATTTTCCACCCGGTCCTCCGAAAGGAATTTTGTTGGTCAGCCAACAACCTAGACCATGAACCGATCGTGCAATTTGCCTGCTTATAAAAAACGATATCTAGGCCACCCATTTTTAAATACTTTTTTGCCTAGTCTTAGGTATGTGGAATAAATTCTAGGTCAGGAGGTTGTCTAGGCCACGTTTCCACTCACCTTTCCGGCTGCAAAAATTGAACTGAACAGTATAGCTCTGTACAGCACATTTGAGCGCATTGCTCGTGCGCCTTAGAGTTTTAGTTGACCTGAAAATATTTGACTATTTAGAAATTGAAATTTTGAAAAGCAATGATTAAAGGTCAAAAAAGATGTTATTTATACACATGCAACATTTCAAAATTCTGATAACAAATATTTATAGGAACACTTTTTCCAACAATACGGTGACTAAGGGGGTTTACTGATAGTAACAAATTGGAGCGGTACAGGAGGAAAATTTAAACCGGCTCTACCCATTTTAGTGCTACCAGCCGACAACTCGCAAAAAAATCAATCAGCCGCACACCCTGCTTCGCCTGGATCGTCAATCACAGCGTTTTGGAATTTTCCTAATTTCTAAAATTTAATTTTCTAAAAACTGGGGATTTTTTCTGTAATTTTTTTTTTACTTTTAAATTATTTTTTAGGATCACGCCTTTTTGAAAATAACTTTCGAAAAATTGTTCGCTAAAAGAGTATAAATAAGATCAGGCTTCGAAAATGTTTCAAAAAATATTTTTTCACGATTCTGCAACAACAAAAAACAAAGACTGAAAAAAAGTAAGAAATTTATTTTGAACTTTTCAAATCTACATTTACAACAAAAACAGTTCTTTATAGACAATATTATTAAAATCCAAATAGATTCCCAGTAGATTTTGTTTAAATATTCAGAAAAGGACCAAACTTTCAGTTTTTGTGTTCTTAAAAAAAAAAATTTTAAATTAAAATTGTGTGATTATCAGTCTCAAAAATTCCAAAAAAGAGGCTTTTAGTTCTGTAACTTTTGAAGATTCAAAAAAAAATTGGGGGAGCCAAAAACTCACGCTTTAAACCTGCCCGCGAGAACTGTCTGCAAATATTCAACTTTCTCATTTTTATTAATTTAATGAGAAAATTTAAAAAATAAAAAAAAATTTTAAGGCATGGATGCGAAAGGCACGCGGGTAATTTTAAGCCCAGGCTGGCGTTTTAACTTAGGCTTCCATAGACCAAATATTTTCATACTTGTTGAAACTTCTGTAAAGGTTTGAAAATTTTTGAACAATTTAGGCCCAAAACCTTTGTTCCTAAAAGCATTCAAAAATTCTTTGAACAAATTCCGGTTATACTATCATAATGGGAGGAGGAGAAAAATATAATATGATTCTTCGTCAGACAAAAATAAATTGGTGAAGAGAAAAAAATGAATTGAGAGAAAAAGAGAAAGAAAGACGCGTCTTCCGAAGAAGAAGGAAACCTCCTGCGCGGGATGCCGAAACAATAAGCAGCAGCCGGGAGTGAGGGAGTGCACTGCACTAAAAAATGCGAGAGATTCACAGAAAATCGGGAGAAACCCCCCGTATGTCGGTCGAGAAACACCTAAGACCTACTTCATATTTCGAACCGGTTCATTTTCATTGGCATTCGTATTATTTAAATTATTTTGACAAGGGCAGTCGTCGTAGATGCTAATGTTGCCAGTTTGACGGGATGGCCGTGTCACTTGGGAAAAGATTGGCGGCAAAAATCGGGGGGTTCCTAGCCACCCTTTATCTTCTATGGTCGGAGAGGCGTTTTCTACTTATTTTGGTAGATGTTAATTAAAAATTTCATCAATTTGGGAGTAATAATGTGGCTGCAAATCATATTGAAATTTTCTATACAGTCAGTGCGAGCCAGCCTTATAAATTTTCTAGTGCCGCCCAGAAAAAAAAAATATCCTAGGCCACCAATTTTTGATCATTAATTTTTTGGCTATCAAATTAAGTAGACCACTAAAGTGTTTCGTCATTAAAATTTTCTAGGCCACCAATTTGGCTTGACTACTAACCTTCTTGGCCATCACAATTTCTAGGCCACTAAGTTTTTTGTCTAGGCCACTAACTTTCTAGGCCACAAACTTTGATGTCAGGCCATAAAGTTTTTCCCAGTAGTATGTTTTGCTCTTCAAATTTTTCAGGCCACCCACCAAAATTCTATTCCAACATTTCTCCGTCCCATCAAAGTTTCTAAGGCCTTTTATAGACGACTTCTTAATTGTAAGTCAAAGTGTTTCAAGACCATTATTTTCAATACACTAAATATCAAAAAACCAAATATTTTCCTTCAAAAACTTTGCAAACTAAACTAAATGTTTCCAATACGTGCTTTATTTTTATATGTAGGCGTTTAGACACCCCAGTGGGGAGGAGTAAATGTTAATTCTTATGATTATTTCATTGGGAGTCACTTTTCTTGTTCAACGTCTTTAATATTTTTGAATAGGATTATCATTGGTATTGGCAAATAAATAAAATTGTGAGTGACGTGGTGATATTGGACATTATTTGATTTTAGTTTGCTTTTTGAAATTTCAATTTTCGGCACTTTAATAATTGTTCAAAATGGTCATTTGTCTAGCAAATTTGCATTTTATTAAAATTTTTTTCATTTATTACATTTTCAGTGAAAATTGCACAATCTTTCATTTAAAACTCACTTCTAAAATGACAGATGCGAAAAAATAATTAGGTTTCAATATTCAAATGAATAATTTTTTAAACGATTAAAACAAAATTATAGTTATTACAAATTATTTAAAAGATGTCTATACTTAATCAACACTACAATTTATGTTTTGTTTTCATTTACTCGAAAATCCAGAAATTTTAGGTTTTCGAGAAAACTTATTTGTTTTTAATAAGTGGTTTATATAAATGAATCCACTTGAAAGTGCGAAAATGTACTTAAAAGAGTCCAAAATAAGCAAATATCATCACGAAGCGCCGAACGTAAGTTTTTCGAAATGTTCAGTTATAGTTTTGGTGAAACTGCCAACTTTACGAGGTTAAAATTTCGGGTTTAATTTTCAAGTCTGTTTTTATACAAATATAAATCAGAGTTATAAAATTTGTAAAAAAAAATTTCTTGGTCGGTATTTAAAAATGTGGGTGATAGGGCCGTTTTTGACAGAAAAAAAGTTTTATAATTGTTTTACATTTTACCAACATAGGAGCTGCCTTAAAAAATAGCTAAAGGCTTGGGGTTTTGCCCTAATGAACAGTCCCAAACTACCAAATATAAATGTAAAATTATTCTAAAAATCTTCAAAATTTTTAACGATTAAAAAAATTTGCGAAACTTTAATAAAGCAATATGGCGAATAATTGTTTCATTCCCGCGATTTTTTGATAATAATTTTTTTGTATAATTCTTGCATTTAATGGCGTCATTGCTTGTTTACATGTCACCATGTGTTTTTCGGCAATAGTAATAGAGGTTTTCAGAAAGCGATTTTCTAGTTTTTGAAGCACATTTCGTTCCCGTAAAGAAAACTTGATAATTGGAAAGAAATGTGGCAAAACGGCGCAATTGACCAAATCGACCAAAAAAGTTAACAAACTGTATTTAAAAATAAATTAATAACCAAAGTAAAAAGAACACCCACATAAATGTCAAAAATCACTCACCCATTTTAGCTGAAATTCAAAAAAGAATTCGGTCCTTCCCTTTTTTTCTAAACAAATATCTCTTAAATCATACATAGTATAATTTTATATGACCTTTCTGACAGTTATATTTGGCATAGTGGGACCTTTATAAGGGAAGTCAAAAAACTGAACTCCGGACTTTGACATGCTATAGTTATTTTTCGAAAAAAGAGTGAAAATAATGATCCCTCCAAAAAATTTTGCTTCCGCGGACCAGGTTCAGCAAAGTTATGACGTTTGGAAAGTGCCGAAAAAAATTCCTTGACCGACCCAAGCAAAAAAAAAAGATTCTTCAAATTTTCAAAAAAAAAATTCTGAAAGTTGATAACAACTATTGTAACTTATTCAAAAATGTGAAAAACGTTTATCATGCACGTTTTTTCTCCCCACGGACAAAAAACCACATTGCTTGATCAAAATTTCGTGAGCAAAATTCTAAAAATTACTTTTTCTTGTAGAATTATTGGTTTTCTGTTATGAGCTATATGCATGGCATTTTTCACTCTTTTGGATAATTTACAAATATTTTTTCCTCTTTTCAGAATTTTTTTTGAAATTTTTGAAATTTTTTAAAAGGGTGTTCCAGCCACTTTCAACATAACTTTGCTGAAGCTGGCCCAGCTAATTTCTTTTGGAGAGATAGCGTTATTTTCACTCGTTTATTGAAAAATTACTATGACATGTAATCCGGAGTTCAGTCGACTTCCCTTGTTAGGGCAAAAAATACCCACAGACGGTACTCCGCCTAATATCAAAAAAGTTCCCACTCGAGATCACTTTTTTACCATCTCAAAATCGTTCGGTTTGTTGGTGGGGGGGGGGGGGGCTTAAAGAAAAACGAAAAAATGAGACACTTGTCAATTTGATGGTAGCAAGTGAAATGGAGAGATACCGGAAAGAGAGTGTAAATAGAAGAAGGGAACAAACACAAATTTCAAAGTTGTCGGAAGGAATTAGGGTATGGAGGATAAAATATTGGAAATTGGGTTTAATAGGATATGTATCTAATCCCGAAGAATATTATTAAAATAACCGGTTCAAAGATCGTACTGAAAAAATCGATAAATACGTTGTGATGGTCCTACTTCCGTCCTCTTTACACAACCTCGTCTTCTTCTTCAGGGCGCATTCCTTGTAACAATGCCCCTTTTCTCTCTTGATGGAGTGCCACAAAACAGTTTGGCAGTTACACAATCGGAAGGCGAGGAAAGCAAAACGGGTATCAGATGATGATTAAGTGAAACCGGAACTGATAAGTGAGAATGGATTGAAATACAGATAGCCGTAAACTTTTAATAACCTAGAATATTAGTTATTAAAGGTGTTATGTATGTTTCGAGAACAAGATTCTGCTTTCTCAATTTTTGAATGAATTATGTTTGAAGTAATTTAAAATTGCCGAATGACGGGTTTGAATATTTGTTTTTTTAAAAAGATTTTTCGTCCGGCCGATTAGTATTTCGCGAAATGTTTTTTAAAATCTTTGGGTTTATGTTCTTCTCTTTTTTCATAAGTCTAAGCTTAGGTTTAGGCTTACTAATTCTAATCCGAAGCATAAGCTTAATCCTAAGCCTAAAGCTCTCTCAGCCTACTCTTTTAAGCTTAATGAATGCCCTAGCTTCATTTTTTTTCGCAGGTTTTTTTCTCTAAATCTCAAAAGCGATGCTACGGACCAAAAATTGGTGGTTCAAAATGTGTGTTTCTATTTTTTCATCAAAAGTTATTTTATGTGACTATACAAACGAGCTGACAATCTTTCTTCAAAATTCCGTTTTTCTTACCAAAAATAGTCAATTTTTCGAAATCTTGCAAAAAACCGTTACCGTTTCCCTAAGTTTTGCTTTCCGTAAATCCTTGTACCTTATGTCGTATCACATGGCATTAGAAATATTTCACTTGAACCAATCTTGTGCGCGTGGAGTACAAGTTAAACATCATATGTGGTGGGTGCAATTGCGCTCTATTGAACAAACTATGTATCAACAGAACGCGTTAACATTATAGCGGTTGTGCAGGTGGGGAAAACAGGAAAAACGATTAGGCAAAACAAAAAGTCTATTATATAAGTTTTCTTCTACACATCTCATAAAGGAAATTCTAATTTTTTACAAAAAGAGCGGGGGGCGCGATTGTAAAGGTTTAGACGGAGCGTTAAGATCTTTGTCGACAAGTGGTTCAGCCGACACCCTGTGAATGTGATTGCCGATATTGTCCTTCTCGTTGATTGAGTCTTTCGAGAAGAGCGCCAGAATGACGTGCAGAATGAAGAGACCGGTGGAGAGACCTGGGAGAGTTTTAAAATTTTTGAGTTTCTAGGCCACGAGTGTCGTCCACTATTATGTCCAAGAAGCTAAGGACAAAATGATTGTTCACTACTGTTTCAAAATCAGCTTGAATCTCAGTAGAAAACAAATTTCACTGGAATATTTCAGCGCTCACCAATAGCAACGACCAGAAAAACAGTCTTAGCAAAGCACACGATTGCATAAGTTGGCACAAAAATCAACGGAAGCATGCATAGGCATGTCGACAGTCCGGGCTTCACACATTGGCATTGCCATTCCTGCCAGAGTACTGTAGACACGTTCTTGTGGAGTGAAACCCACGTACACGAAGTTGTAGGCCACGTGAGCGGTGTAGTCGACCGAGAATACCGTGGCGAGAAGGACGTCCACTTGGATTACCGGGTCCAGGTCGGCACTCCAAAGGGAGAGAGACGAGAACTGTAAAAACTTAAAAAAAAGTAACTTTTTCAGATTAAATCCGAAGAAAATAACATAATTAATAAGGATTTTGTTTCAATGGTTTTTTAAAGTGACAACTACTCATTTTCAGGTTTTAAAAACTTTGACTTGATAAAAAAAAACATTTTGAGCTACTTAAAAAGGTTTTGAATTCCCATCCAAAATCTTTGAAGAAATACAAATGATAAAAATTCTTAAAAAAAAATTGTTAGCAACCCAAGCGTTCGCTAAAGATCGTTGTCGTTTTTTCTCAGACAATTTAAAACATATCCCGCCATGATATATATTTTCGGAGAATATCATTTCTCGTAAAATTGTTTTCTCTGCAAATTTGAATTCTCCGCCAATCATTTTTCTCAGAAAATTTGACAAAAAGGATCAAAAACATGAAATTTCCGTATGGCAAAAAATGTTTTCTCAGAGAATATGAATGTCCGCCAAATATATCAGATACTTTTAAAGTCTCGTCAAAACGTTTTCTTCGAACATCTTAGGATTATTTGGATTTGTAGAATTTTGATCTTGATTTAAATTTTTTAAGTTTTCTGAAAAAAAACAACCATAACAGATACTTGCAATAACAGATGTAATCACGCGAGCAACTGCATTAAAATTTGAAATACAAAACAAACGATTGCCATAACACAGCTAGTAACCGCAATCGATCCAAGTAAGTCAGTGGCCAACATCAAGATGATACTGAGAATTGCAGAGTCACAGTCCAAGAGTGTAGTGAATTGACTCATGAAGAAGTTCGGATATGTTGCATTGCACGTGCTCTTTCTGCCCATTCAGACATACGTTTACCGAGCCCTGAAGTGTCAGAACCCTGTGTTGGTCTGAAAATTTGGAAATTATTCGGATTGAAATTGAAAAGTGTCTAGGAATTAAGTTTGAACTATTTGAGAAGTTTGTATTTTAAATTTTGCGCTAAGTTGCCTGAAGAAAAACTAATTTCGAAGTACCTATATACCTACAATATTTTTCAAACTCAATCTTTAAATTTCGCGCCTAAAATATTTCGAACTTAAAATTTGCGACAAAACAATTTAAACTATTTGAGAAGTTTGAACTTTTAATTAACATTTGAACTCTTTGCGCCAATTTTTTTGCTTGGAAAATAACTTTTGAAATTCTAGTTGCAAGGAAATTCAGAAAAATTAAGGATGTAATTTTTTTATATGAAAAACTCTTAGAATCGATTTCGCGAAAATTTTTTACTCCTCGTGAATTGTCAAAATTTAAATTGAGTTTTACAAAAAAAATTGGCGGGAACGTGAAGTTTCATTAGGAAATTCAAATTTGATAGGCGTTTGACTAACTTATTATCATCTCCTGATATTTTACAAGGGTTCCGGGCGATCGCATCTCATCCATGTAGCGTCGGAAGATTATCATAAGATGGGTGGTAATTTTCTCCAACCAGAGTGGATAAAGTATTCATGGTCTTATCAAAATGCACATACTGCCGGAAGAAAAATCAGACTTCGATTGTCTCCACGAATACCTGGCACGTGTTCGAGCCGATCCATCAAATTGTTGAAAGAGGCGTACTGAAAATTGAATGGCCTAGTAAGTAAAAATTAGATCATGAGCTTACCTCTGCTTTGATCTCGATATTTGGAGGTTTGTTCACTATTACTGTAATGGGAACGTAACGGGATAGCAAGACTGGCCTGCAAAAATGATAAATGCTTAAAAAATACAACTTTTTTCTTTTAATAACGTAAAGAGCTTTTTAAATCGATAAAATCAGTAAATCGGCATTGCAACTGTAGACCAAAGATAACAATTATTGATTTTTCTTACAAAGACATTAAAAATAAAAAAAACTCAATAAAATTAGCGATTATCTTTCCAAAAATCTGAAAATCAAGTCAAATAATTTTCTTGTCGGTATCTTTTATGTTAACCTATAAATACCAATTATTGATTGTCTGGAAAATCAGTAAAGATTCAAATAGATTTTTTTGAGAACCTAAAAATCAGTAAAAAATAAAAAAGTTTTTTCAAACGCTTACGTTTCAAACAAATTCTTGATTTTACTTTCAAACCAAATTCATATTCGACAACGAATCCGCTTCGTTATGGGTCAGAAATGCCTTAGCTGGTTCAAAGGTCGTTTTCGTGGTCACATACTCCATCATTGAAGTTGTCAACGCATACATCCCAAGGCGCACCATACTGCACGCTACACGCCCCTTCAGGGAGCACACGAAGCTCGAGGACTTGGAGAGCCACGTGTCGGCTCCCGGGAAATTTTTGGCTCCGTATCATTGGCGATGGATTGGTAATCTGGGTCGTTGCAGAGGAATTCAATTGGAGCTAGGATCGTATGGGTGAAGATGTAGTCGAAGAGGCAAGGCGAGCGAGGCAGTTAGGCAGAACAAGAACATCTGGAAGATGAGTTTTATTCAAGCTAGCCCACGTTCTCACAAACTTGGCTGCGTGCCAAAGAAGGTTACCTGAGGCGTTGGCTTAGAATCCATTCCAAAAGCAATAATATTGGTGAGTGAGGTGATTTTACGATGGTCCAACATCGTGACAATCACTTGTTCCAAACGGCGAGGTCTCAAAATTTCATTTTACGATGCTATTCCAATACCCCTACAGTACTTTTGCAGTTTCTCTACAGCACCCCTATACAACTACGGTACATTTATTTATTTGTATATTTGTTCATCAGGGAACGATCCTAAAGATACAATTACAACAAGGCAGAATCTTTTACAATACAATGCCCCACCCTCTTTTTCCGTGAAAGGAAACTTACGTGTCAGTAATTGCAATATGATGTTTCCATCTGAGAAGTAGAATAAAAGCATCATCAACTTTTTCCAATTCCAAGTACCAAAAACTGGCGTAACACATGTAAATAGAGAACGACGGGAAGCCCATCCAACAAATTGCTCCAAACGAGGCGGCAGGCCATCGGAGTGAGCAATGATGTAACCAGATAGAATGCCATTTTGACAGATGACAGGCGGACAATGACAATGATGACCTGCGTCAGGTGGGAAGAATCCGATTGTCATTTCGTAGCTTCAATGGTTCCTCGAATCTCACGATTTGCTACTTGGTCACTGACAGTAGATGGTGAACTGAACGTGCTCGAAGGCAGAGGAGTTTGTTTTTTGGAAAGTTGGAAGAGCTCGTCGATTGCGCCCTGGGAAGTATAATTACGAAATGCCGAGTGCTTGCCAGTTTTTTTGATTATGTAAATTTGCTTCCCAGAATCCGAAAATTTGGTTTCCCGCAGAAAAGACTGAAATTTAAATTTCTAAAGATTGTTCAGATGTTTGTTTAAGTTTTCTTTAAAGACAAAGATTTGATTTTCCTATTGAAAATACATGGTGAAAATTCAAATTTACAAAAATTGAGTTTTGTTATAAAAACAGACTGAAAAATTGAACTTCCTGATTAAAATTGATTGAAATATAAGAGGCTCCTAAAAATCTTGAAAACTCGAAATGTAAATTCAAATTTCCCGTCCAAAAATTGACAAAAAAATTTGATTCTACTTTCCTGAAACAAGTTAAAAAATCAAAGGTCCCTCAAATAGTAAAACTGACTCAAAATTAATTGAAAATTGAAAGCCGTATGAGTCTTCTAGGCTATTCTCACCAAAGCTTAAACGCGAATTTTCCTTCTGGACATGTACCAGACCTCGAAAAATACCACAGCACCAAGAATTTGGGGCTGAGCCTCTTGGTCGGTGGTTCTGAAAGTGTCAATGTTTTTTCACATTTTTCCGGAACTTTTTATAGTTAAAAAAATGAAGTAGCTGGAAAGTGGCTAAATCATAAAAACCTTACTATTTTTCCATCAACTTTTCATTTAACATTTCAAAAAAAATCTAAAATCCGCATTACTCAAGTGAAGTCCCAGGAAAATATACGTGCCAGTCCGCTACATATCCGGATAGGTGAGAATACACTTGCGTGGCACCATGTATGTTTCTCCGCGTCAAATTCTGAAAATTGCCATCTGGTCGTTGAAGAGTTTTCTAGTCCACGACCACCACCAACAGTTTCGGTTTCGTTCGACTTTTTAGAATATCGAAACTGAAAATCCAACAACTTTTTGAGAAAAACTTACAAAGCTGATAATGTTTTTATTTTAACTTTTTTCACCATCATTCATTGACATTTAAGAATATAGATAAATGGGATAAGACCGTCCAGGTTTCTGTTCAGTTCTCCCTGTTGTTAAATTCATTAAGATTGTGGTCCCCAAAAAACAATGTTTCTTTCTTTTTTCGATTTTCAATTTTTAGATTTTTCAATCTTCACTAAAAACATCAATAATTGAAAAAATCGAAAAATGACACCCTAGACCACCACCTACCTCTAACAAGTGAAAGGGGCTGGAGAGTGGATCGGTAGCAATTTTTTCTTCCTTCCCATCATCGTGGTAGCCGAATGCCGCCGATAGTCGATTGTCCACAGTATAAATCTAAATTTTTTAAATTCCCGCCAGAAAAGTGGGCTTGACGGAGAATCAACTTACGTCTGCCAGTCCTACGCGCCTTCCTGGAGAATACTAATTTTCGCGCTGGGCGGTAAAAATACAGAATGCTCGTGCCGGATAGATGTCGAGTCCGTAGTATTCCATAGCCAGATACGGTTGAGTATTCACTGAAAAATGTAAAAAAAGTTTTATAGACATTTCCGCCAAAAGATTTAAAATAGGAGTTTTAAAAAAATTAACAAAATAGTTACGAACGAAGTTTTCATTTGCTTTAAAGTTTCTTTTTTTTCTTATTTATTTTTGATCAACTATTTATATTGGGTACTTTTTTAACTTCAAGTGGAATCCAAATTTTCTTCCCAGTCAACCAAACATTGACCATATCACAATAAGGGAAAAGGGAGAAAGGGAAATAGTTAGAAAAAGAAAAACATTGCGAAAAAACGTGTTATTTTTGACTGGTGGTGGAAGTAGGCTTCAAGGTCAGTAGTCACTTACTATCCAGCATCTGAATCATGATAAAAGGCTTTGCGAATATCTGGCTCTAAACGTATGTGCTACAAGTCCTGAACTGAGAACTCATAGGATGTATAAGAGCTCACTGAAAATTGTCCAACTTGAAAAATTTCGATTTTTTATGTTTATTAAATTTTTTCTGGTGTAAAATAGCAGAAAATGCCAAAAAAAAATGTATCAGACACAACTTCAATTTTTCAAACTTTTCGTTGTAAGACCATACAAGATACAATAAATTGTCGTTCGAGAGCGCTTTGCCCATGAACCCGTAACGGAGATTTTCATTCGACTACTCTATAGACCGCGTTGGTGATTCTGAAAATGACTTTTTCTTGGAAATTTAAAACTTTTAATCTGGGATTTTTCTGTTTTTTCCAAAAAATTATATTGAAAAATCAATTAATTAAATTTTTTCAAACCTATGGTGATTCATGATTTGATAACAAGAACATAGCTTCCTAGTTATAATTATCCTCAGTTTTCACGAGAGTAAAAAAAAACGGTAATAAAAACATTCTTTTTTCTATTTTTCTCAATTTTTCGATGTATTTACCAAGAAAATCGATTAATTTATCGATTTTTTTTTCAGAATATCTGACCGTTTTTGTTATTCATCGGAAAAGTTCAATATTTTATTTTTAGGAATTTGATTTCCAAACGTATATTGGTGGCCAAGTTTTCCCATTACTGATCGACGCATAAAAGTTAAAACCTCACAAAGTATCGAATAAACCGGATAGGCGGCTAACAGCCGGCACTGGCACGACGGCACTAATCACATCCCATCCCATTGAAACTTCGAAATTTTTTTGGATAATATTTTAACAGAATTTAAAGCAGCATGCAAACTCTCTCCAACAAAGAAAAATGTTTTTAAAAAATTGAAATTCGAAACACAAGCACGTGAAGCAGAGAATGCAGAAAACAATACCACTGTCCCAAAGTAGAAGTGAGGGAGGGAGGGCAATTATTTGCAGAGGTGACCAACGGGTTCGTCGGGTTCCAATTTTTCGGACACGGCGCAGAGGATTTGAGTCATTATTATTGTGTATAGAGAGTGTAAGAGAATTAGAGAATTTAGATGGGAAACTGTACGTACTTCTGCGAAATGGTGCACTTTTAGGATCGGCGGCCTAGAAATTTACATGGTGCTCTAGATGTCTAATAGATAGCCTAGATCTTTATAACTCCAGACAATTACTTGGTGGTCTAGAAGTTTTTTTTGTGACCTAGAAATGCAGATTGTGGACTATAAATTCACTTGGTGGCCTAGAAAATCATTTGGTAGAAATGTACTGGCCTGGAAATTAACCTTGAAGCTTATGCTAGAAGCTTTGTTAAGTGAGCAGACAGCCCAGCCAAATTCACTTGATTGCCTATCAATTCACTTGGTGGTCGAGAAATGTACGTGAAAGCCCAGCAATATTTACTTGGTCTAAAACATTTTTCAGTTAGAAATACATTGGAAAAAATTTCGATTAAGATTTATATTCTGGCGTTGGATGTGGTGACCTAGATATTTGTCAAGGGACTGATGAATTCATTTGGCGTCTAATTTTTTTGGTGACCTAGAAATTGATTTGGTGATCTGAAAATTCATTTTAACATGACCTGGGAATTTACTTGGTGGTCTAAAAAGTCTCATGGTGCCGGTCTTAAAGTGTGTTGCAAAAATTATACTACAATATTTAACTTTGAAATAAAAATTCAGCTCTAGATCTGCAAGAAAAATCTGTATTTTCTCAATTCAGGATTTTGATTAGTTAAAAAAAATCGAAATGATTGTTTAAAACGCGTTGCAAAAAACAATTTTGTAGCTCAGGAATGCGCTATTCTGGGGAGTCAGATTTACTGGATTTTACTTTTTTTCCTGCAATTCCAATGCAAAATAAGGTAAATGAGAAAACTAACACGGCGGTACATACAGGGGCATCTTGAATGTAAGGCAGTGTTTAGTAAGTGGACCGAGTGGACGGCAAACGCTTGTATTTTTCCTGTGTCGATGGGGGATATCTGTACCGCGGTTGCACACAAGAAACAAGTATTTTGATGATGATACGAATAAGAAAAAGAAAAAGGCAGCAAAAAAGTGTGTGGCAGACGACCACCGTCCATCGGATTAGGCTGAGCCGGCTAAGGCAAACTCGTTCTACCGAACAGAGGGCCGTTTGCAACCCCCAAAATCCTCTGAATGTGACGTCATTGTTGGGGCGGCGGGGTGGCGTCCAATAATTAGTGATTTTTTTTTTTGTATTCTGGAAAAAAAGGAAAAAATCGAGAAACATTCTTTTGTGTTTTTGGGGAGTCTGTCATGTGAAATTTAAAAATGTTGGGTACAATCAAAAAATCGTTTTGGTTTTTATATCTTATTTCAGGAATGTTTAAAAATCTCAATCGTTTTTCTTTGAAAAAACAAAAAACAACAAACATCAGCATCATTTTCGATTTAATTGTTTGTTAAAAAAATAGAAAGCGGAAAACACAAAATTTTCCGATCTTCTCGAAATTCACAAACTCATAAAAAAATCGAACTCCCCTTGTACCCCAGCACCCTAGCTGAGTCTTGCTTCCTGGCCAAAGGCATGGAGGGAGGCGGGCACCTCTTTTGCTTGACCTAAATAAAGGTGATATCCCAGTGATAAGGAAGGGTAATGATCCGGAAACCGCCTACCAAAGTGCATAGTTTCTGCGTTAAAAAAAGTGACAACTGACATCACACGGATGCTACAAATGGGGACTCACATGCCGGAGAGGGAAAATTGTAAATTTGTACGGGTAAGGGGATCAATGTTCAGTGGTGAGGTCGCGAGGACGGAGGGAAAAGGTGGAATTAGAATTGAATGGGAAATTGGTGGCAAAACGGTAAACAGTTCTTATTATCAAATGCATGAGGGATGGAGAAACCTAAGGAAACCCTTGCAGAATTTTGGAGGGGGTGATGAAAAGTATTGGCAACACCTTGGTGGACGAGAATTTTAAATTGATGATCCCATGGACTAAAAATTCAGATGATGGCCGAGTTTTTCATATTCGCACCGAAGAATACGGCAAAATGATGGCCTAGAAAGTTGTTGGAGCGACCTAATCTTTGTTCTTACAAATAGATCTCTAATGTTTCATCGAAGTCAAGGGATGTGAACTAGAAATATAAGATGGTGGCCTAGTCAACAATTATATTTATGGTTCGTCAAGAGGCCTAACTCTTCAATCACGAAATATTCTAGAGTTTAATCCTATAATTAGTATTGTGGACTAAAAGTCGAGATAATGACCGAACTTTAGCTCTCAACATCAATTTGGCCTTGAAATTCCGCCATGGCCGAATTTTCGTAAGTCGACCCCAGCGGTGGCTACGAGCCAAAAAACATAATTCCGCATTCATACATTTTAATATGAGGGAAGCCAGAAGTGCGAGCCTCATTATTTTGTGAGTACATTTTTGACTATCGTGCCAAAATTCCAAAATCCTCAAAAATTTGAAATTTTCGCGGCACAATTTCTGGTTTTAAATCTCTTTTTTTTAGTGTGATGTAGGGCTTTCCAATTTGCATAAAATAAAAAATCAACAAAAAGCCAAACATAATGTCAAATGGTCAGTTGCAATAAGAAAACAAACCTGCGTTTAGGATGGCCGAACCAGAAAAATAATTCAAGCTTTCGATTTCGCCCGAAAAAAATGAGGATCAGAATGAGAAGGTGTCGCCTATTAGAGATTGGAGGTTGTTGAGAAAAAGAGAATAGTGGAGCGGGGGGAAAATGATGAGGTAGAACGGAATCGAACATGCAAATAAAACGAATGTATTTGGTAGGAGAGGGAAGGTTACACTGTGTGTTCTGTGTTTGGAAAAGGATTGAAGTGGTGGAGGACTCTGGATTTAATACTACTTACCTGTTCTGATCAGGTTCAGAGGTATTTCAGCAGTCGCTCTTGTATATTTTGTCTTTTTAAGTTTATTTATCAAATCTTTTTTTGTAACTTTGAATCTGATGTCAAACTTTGGGAACTTTGAACTCGATGAAATTGCTCAAAAAGTAAAAGAGAATTTGCGCCCAACTCCTTTTTCGAATTTTTTTCGAGATACTTTGATTCTTCTTAATTTCAACACACAAAACTTCGCCAAAATATTGTTACAAAATTAACATTTTTATTTGTAAACAGCTGCTAAAGCACCACAAATGTGAAATTGATGCCTAAAATTAAAATGGAGTTTTTCAAAAAAAGCTGATTGAAATAAGAAAGTAAGCTAAATGTATATATATGGGGAAGATGCTATTTCGAATCTCGCGTTTTTTTAGTTGGGCATCTCCAAAATATGAAAAAAATACAATAAAAAGCTCCAAAAGATATCCAGGAATTTTTTCAAACTCACCAAGAAGTATGTTTTGATAAACAAAAATTTGAATTTTTCGAATTTTTTTATTCGTATAATACCTGTCACACTTATTTTCAGCATAAGAGGAAAAAATAAATGTTGAACTTTATTTAATGATAAAAATAGTTTGTCGAAAAGTTTTCGTAAATTTAAAAATTTAAGTTCTACCAAAATAGTTTTTCACCTGGAACAAAAAACAAGAATTTTGTTTGAGCTTATATAACACTACAACCACATTTTTGAGAACATGTCTAGCCTCTGTCAAACAGTTTTCCGGTAGTGGGTGTGGTTGCTAGTGATCAATAGATCTTCGTAAAAAATCGAAATTTTCCGTTATAGCCTGCTTTATTTTATGTGTTTGATGCTATAAGCGTTTGGATTGTATCAGTCCATATGATTTGACATTATTCGCAATATTTTTTTAAATCCGAATGTTTTTCGAGTCTCTATTTTTTGTAATTTTCCAGACGGTTTAAGAGCTAAGTTGTAGCTATTCTTTCCTATCAAAAAATGCAGGAATAAATACTAACTCAATTTATGCAAGATAAAACATTTACAGTGGTTTTTTTGGTCGAAACTAAATTCCGCAGAATTTGAAAATTACTGAAAGGGTTTTTCCTTTTTTAATTTGTACTCCCTACAGTACCCGTTATTTTTGAATTACAATTGGATGTTCGTACCTAAAATTGACACTTTTTCTCTAGTATATTTCCGAATTCAAAATTATCAGTTGAAACTAGATCCCACCAAAATAACAAATTGATAAGAAAACGTAGAAAGGGGAACGTGTACCCTTACAATAATATTAACTGTTTTCCCTCCAATTTTTTTTATTTTTCAAGGGTTTTATTCTTAATTCTATTCACAATTTTTCAAAAAATATTCAGCAAAAAAGTAGGCGTGCTGACTATATTAACAGTATAAAGTGAGTCTTTTTTGTGAGCATTAAAAAAATCAATTTTTTGTCCTAGCTTTGCAATAGTGGCAGCTCAAAAATTAAATGCATTTGTTCCATTTTCCGTAAAAAAGACAGTGGAAGAGTTTTTATCCGTACTTGGGCAGGCTAATATTTTGTGGCCGGTACAAATTTTTCGCGTGGTGCCTAGAAACCTTTTTTACGTTTTTTCTCGGAAACTTATTTTTTTCTGGCCGTGAACGAGTTTTGTTTAAATTTCAGGTGCTTTGAATATTTTGATGACTAGTTTATATTTTCCTGCTTCTAGTAATGCTTGGCCAAACGTCTTCACGTGGTCGGGCTTTTCATCGGTTAGCTTGATGCCCTAGGAACGTTTTTAACCTGGCGTTCTCTAGACAATAACTACCGTGGACTCGAAAGTATTCTACGCCACGAAATATTTGTAGCCTAGAAATCAAAGTCACTACCCGTGTGGCCTACGTCTCCCTGAGCATAACGTAGTCCTCGAGAAGTCCAGTCGACGGATACTGTCTACAAGATTAACGGCATGATAATCCTCCTGGTTCGATTACGATGTCCACTCATTCACTAGTCGGCGTTGTTGCAACAATGTGGAAAACTTTTTGGCATTTTTAAAGATTTTTAAACACATTTTTTCTGTCGGAACTGAGAACCGGCTGTTTGTAGAGAAAAAAATTGCATTTACTTTCCTTGAAAAATCTGTTAGCGTTCTTCACTCGCTGATTTATGTACCGTTTAAGTTTCAGAGACAGCGTGGGATTGGGGGACTGGACGCAGACAGCGAGTGAGTTTGCGTCTCCCTCTCCCTCCCACTCTCTCATAAGTTTTGAGTGTTCATAACTCGGAGAGTGGAGCTATCGAAAAATTCAAAAAAAAAAAGCCTAACAAAAAATTAATATAAAAAAATTCTACAAATTTTTAGTTGCTAATTTTTTGATAGCGATGCTAGGTTTTTAGAAAGGATGACGTTTTTAACTTACCTCGACTCTTTTTGTGTTACCAAGTTAGTATTCCTCTAACAAACCGCAAGACCTCACCTCATTGTAGCCTATTGAAATCTGTAAACGCCCAACGCAGGTTGCCTAGATTTGATATCCGCCTCCATCTCAGCCGTTCTCTTTCCATATTCTCCTAACTGTTTGCGTCTATTTTAATAATGGGATTATTCGGATTTCCTATTTCCGCTCAAAAACCAATAAATTTATTTTGTAGAGCGAAAAATTCTACACATTTTTGGAGTCAGCAAGTTTTTCAATGCACCTCTCCTCGCTGAGTTTCGTTAAGATCTATGATAGTAAAAATATTTTTGGGGCTAGCTATTGTTTTAGGATAATCAGGATCGCACGGACTTAAGTCTAGCCTCATTCCGAAATTTGTGAACTCTGTAAGTTATGTTGACTAATAGTATCCCTCTCCAGCTGTTGTTAATCTCCTCCTTCACTCCAGTTGTGATCGTTTTCGCTCTTCTCTCGCTTTTGCGCCCTCTCTGTAGGGTCCAGAGAGTATCAGTTATCTCCAGGACGCCGTGTGACGTCATCGCTGACAAGCCGTAACCTAGATAAAGCGCCCGGCAGAAGACCTGTTTTACCCCGACATGCCATTCGTGATAAATTTAGATTAGTCCTCTCACACTCTACATCTCTCCATGTTTTTTCACACGAACTATTTGTGTTTTGAAGAAATATCTTTAAAACTTTGCTTTGACTAATTGATAGCATAAAATGTATTTTTTCCGTAGCTCAGCAAATGGCGTAACTAAATGGTGTGAAATGTTAGATAGGGGACCGGTTTTGGCGGAAATCTCAGAAGAAATGGAGCCCTGCCTGCATAGAGACCGCTTTCGACTGATGACATCACAGAGTAAGGTGTCACATCTAAACACCATTCTTATTCTCTTTTTGAGGTCCAATTAGACTAGGCGGTCAGCGTGCTCTCGATTGCCCTAGCCGATGACGTCACATATTTGCCATTCACAACTTTCTAAACTTCAAACATTTTTTAATGTTTTCCAAATTTCAGCCGATTCCTCCAATGGGAGGACTCCCCTCCAAACATCACCACCTAACTGCCGTCCACGGCCACTTGTGGCCCAATAAAGGGTAACGTCGGATATGAGCAAGTAGCTCATAAATTGAGCTCTCTAAAGTTAAGATGAAAAGAAAATTATTTAGGAAGACGCTTCAGTGGTGTAGGGGTTCCTTGGATTACCGTACGCCACCAATTGGAGCCTTGCGCTTTAATAAGCCCTCATCGGAAACGGAGCCGCTGTGGATTCTGTTAGCCGCTGTTCGGGCCATATTAGGAGTCCGCAAAATGATGAGCCACTAGGGCAGGTAGGCGCCTAAATCAGAGCAAAACGCTGTCATTTTTATAAGGCTGTTCAGTTTCTAAGGTGAACACAGTCGGGAAAAGGTGCACTGTTTCAGCCTGAAAGTATTCACTCCAAAGTGGGAGTCAAATGAATCCCGACGGCTTCCCAGTGATGGTCTTCATCCATGGCGGAGGCTTCGGTGTTCACTCATCCAGCAACTATGGCTGCGTTTCATCGCACGAAACCTGCACCAAGGACGTCGTCGTGACCACCTGTTTTACTAACGCGTATGCTCGGCGGGATTCTTCACCACCGGCGAAGTGTGCCTTGGAAACCTTGGACTTTGTCCGGATCAGACTTCCCTGCCGCAGTCGAGTGGGTTCAGGAGATTCATCCGAGGAGACCCTGAATGTTACAATCTTTTTATGGCCAAAGTGCAGGTGGAGCATCTGTGGATCCCTTGCTTTGCCTATCGCCGCACTCGAGGGGATTGTTCAATCGGGCGATTCCGATGGAATGGAGAATGTGATGTTGCGAGGCGGACTAGTGAGTAGCAGGCTCAGTTGTCGAGGGAGTTTGCGAGATACCTTGGATGGGAAGTGGTAAGTGATTAACGCTTAGTCTTCAGATGTTAGAAAGTGCGTTGTCATCAGAGTTGGATTGAGTTTTTTTAAGCGTAATTTATACTAAAGCCCTATCGAAGCAGTTTCCTTGGCTACTTGGCCTACCACACTCAGCCGACGCCCGTCATAGCAACCACCTGGAGGCTCAAGACATTTCCTATAGTTATGTTCTATTGCAAATTTAATACGGTGATTATTCCAAAAATCTCATGACGTATTTTACCGAACGAGAAACCAGTGCAAACTTGTTGAGTACCTAATTACTTCACAGACAACGACAGTGAAGACCTTGTCCAATGGATCATCGACCAGAAACCCATAAGATCGAGATGGGCATAAACCCGAAAAGAGGATTCAAGCATTCTCAGGCTGGAAGCTTGTATTTGGTGCCAAACTTTTACGCACAGGCGACTTCTTCCCGAAACCCCCAGCATTAGAAAAGACGAAGCCCAAAGATTCGAATAATGACTCGGCAGGAACCACCAAGAACGGGGGTCTATTTTTCAGTGAATCTTCTGAAAATTTTCTGAAAATTTTCTATTATAGTCGCCCTCGGTGCCTTATCGAAAAATCCGGAAGGAATTAGTTCATGGGAAGAATCTTTAAAGAATGCGACTATGGCGAGCGTGCTGACGCGATGTGCTGCAGATGGTCTACGACTTTTATGTCAAGGAGGTACATCCGATCATGAGAAGAATATGCATTGTGAAGATAGGTCAGGCATAGAGCCTACAGGGCTATCGAGCCAGTGATTGAGTCCATTGGAGACTATTCTATCAACTATGGTACATACCGTCTGGCTAACATTATGACGGATCTTCAACACGATGTATACCTTACTTCTATCAGTTGGACTATCATACTCTGCAGGATTCGGTGTTCCGGTGGCTTCGGAGCTTCCGTGTTTGGGTGAGTTTAGGATGGGTCAGATTTTTCCTAAGCCCGGGGCCACATGCTCTTTGTAGATCAGCAGTTTTAGAAGTTCGAAGCGAGAAATGTATGAGTATGGGTAAAACTTTTAAAGATTGAAAAGAAATTATCCAAATAATAGGACTTGGTAAAAATCCCTTAGGCTACTTGTACGGCCGTAACCTGTCACTAACGATTCTAATAGTGTACCTTATCTGAACAGTATTGCCAACTAATTGAAATTAATTCTGAGACTCCGAGATTAGCTAGCGGTCCTTTTCGCTGTGGCCCAGTGCCCATTTCCTATGGCTCAATATCCTTTTCAGGCTCCACACATTTCACGGAAATCAGATATGTGCTCGGGAATAATCTCGAAATTATCCGACCAAATGATAATGATAAGAAGATGCTTCACGTTATGACAACTTATTTTACAAATTTTGCAAAATATGTTCGAGGTCCACACTTTTGTGTACTCGAAATTAAGCTGCTTTCAGAAACCTCACTAATGGAGAAAGGAGACTAGAATGGCAAAAGAACAACTCGGCACACCTTGGCGTTCGCCATTTCAAGATTGATCTGGACGATTCTGAAATGGTTGAGGACTCTCAGCAACGGAGAGCCGAGCTATGGGATAAACTGAGAGCATTTAATGTTAGCAGGGCTCACATGTTAAATTGCTGTTATTTTTACTTGATTGATTTTACGGTTTTATAAATAGTTTAGATTTGTTATATATTTATTTTTTCTGAGTTACATACATACATCAAGAAACATTTCTCTTGCAATCTAACTGAATTTTATTTTATAATCAGTTGTTTTTATTAATCCTGTACTATGCGGACAAGCGTAAAAATCTGTTTTAATCAAGAACTCACCTACCAATCGTTAACACCAAAAACCAACACGGTTCTGAAACAAACGATGCATAAGCTGGCACCATTATTAATTATCCGCATACAAGGTTTATCAAATAAAGGAAAAAGTCGGAAGCTTCCAACATTCAATATCTCTATTATACTTTCCCCTTTCCATGTATGTGCTTTTTGTGTGAAACCAACTTAACCGCCAGAAAGCACATAATCTATAACAGAGGTGGGCGGCAATTGCCGCTCGGCGAACATTCTGATTTTTTGGAAATTTTCATTTTTGGCTAGAAATTGCCGCTCTGGCGTTCGCCGGATATATTTGCCGAGGCGCAGTGTTTAGAGGATCCTCGTTTTACCGGAAACACTTAAAACTGTGCCTTTTTGAAAATATTTTATTTTTATTCTTTTTTTCGGCAAAGTTGCCGGTTTGCCCAATTTGGCAATACGCCGGAAATTTCAATTTCGGCAGTCGGTGCAAGTCAATTTGCCAATTTTCAGAAAAAAAATTTCGACGCCCATCCCTCATGCATACCGTTTTTGACTCAATTTAAATAGTAACCTTCCACATTAATGTAGTAACGGTAAGTTTGCATAATTTGTTTGAACTTTGAAAGCCGCTGGGCATCCAGCACCTGCGGTAATCGATCTCCTTAAAGGGTGTTTTCGCAAATCTACCAACATAACAGGAGTTTGTAGAAACATGAAACCGAAGGACAACACATTTTGAAAGTCACATTTATGTATCTGCACTTGCTAGCTATGGAGTCAATGAAGCATTACGAGAGACATGTGTTCATTCCCGAATGGAGTATGAGTAATAAGGTTCTTCGTTCACATTTTATTATTACAGGCTTGGGTCCCATATTGATTCATATTTTACTTACTTTTCAATTCATGTGTTTGTAATTTTTTTTCAATTAGAATACTATTATAATAAAATTTCTAATAATGGACAATCGAAATAGTTGCAAGTAGAATAACTATTTGTACAGTGATGCCTATAATTGTGGATGTTTATAATGTGTCTAATATTTCAACGCAATCGTGACACAAGCTCTATAGTATCTCGTGAGTGCATTTTCGGTGAGGTTTCAAAAAAATACTCCCTTGCTCGCCATACGTTTTCAGTTAAAAATTTCTTTAATAAAAAATTATACTGCTTATTTCTCGAACGATACCTTTAATGTTAACTGCGCCTACCATGTCCTTCAATCCCACTAGTCAGTTATTCTTTGCAATTAAATGTCATGGAAACGCTTCTTTAATGTCTAAATCATGGATATCTCCATCTCAACCATCCATCGTTTTTTATCATCATCATTCTCGTGTTCTCGTTCTCCGGGTCGCCTCCGCTTCTTCATCATCATCACCACGACAAAACGTTCTTCCTAATCGACATAATCCCGCATTTAATTTCTCGAATTGTTAGGTATGAATGACACCCAAAAACGGTCTCATATTCGGAAAAAATGGGAAGATTGATTCCTAATTTATTGGTTTTGACCGGTTAACCCCCACACATGTTTTTTGTACCTGCGTCTATTTTCGTCTAATTTTAAGAAGTCAATGCCTAATTGTCTTTTTTATTTTCTGTGAAGTGAAGTATCAAGATAAAATCAGTTTGGCGGTCGTCTCGCTTCTTTCTCATTTTTCGAAATACCCGTCGCAATATGGTTTTTTTATTACACATTTGTGCGCACTTTTTTGCTACCCTACCCCCCCAATTCTGACTCACGCTTGCATTCCGGAGACTGCTCTGAGAGTTATAACAAAACATAATTGTTATATAAATGTCAAAGTTTTTCGCAAGCTGAAAATTTTTGCCAGCTGAATTATTCCTTGCCCCTTCAAAGTAGCATAAGTCTAAAAATGCTCGAGTTATTGGAAAGTTGCTAATTACAAGTTAAAGAGTTTAATTGACTAGTTTCTCGATTTACAATTTTTGAACTTTATTCCTTGAAACTCTAGCAATGAGGGGCAGTAAGTGGGGACTCCCCCACTGGGGAGGGGAGAACCTTGTCAACCCACTAGGGAGGGGAGAACTTTGTCAACTTTAAAGCCACGTCCTTCTGCAGGGAAAAGACTCGCGCTATCAATAGGTCAACTAACAAAATGTGTTAAGCTCCACATTTTTGTAGTTAAACGTTTTCTGATATCACAGTAAGGTAGTTTTTGTGAAACCATCAAATCTGTAGGTTCTCCATTATTATTATCACCTAGCACAGTATTATTACCAGCTGATAAGTATCCGTCTTTTTTGGATGATCTTGTAAAGGAATATACCATTGTACTTCATCTCCTTTTTCTGTGTCTACCCTTATCTTGGGGTCGATCTTCTCCTTCCCGCATACGGTCTCCTCTTATTCAGAAAGTCAGGAGGAATATTCCGAGAAATTTTGTTTTGAACGACATGTGCGATCAATCGCTGGTCCAGAAGGTTTTCCCACTACTTGGCTCGTGTTCTCAGGTGAGTATGCGCCTTTAAACATTGAGGGTACTGTATGCACCATAACGCAGAATTGCAGATTCTAAAGTTGCGCAGGTTTGTTCTACACGGGATAACCGTAAAATTTTTATGTCCCTTTAATAGAAACTCGTCCGAAGAATTGGTAATGTACGTGGAAAACGACTTTTAAAAATGTTTTTTTACTCCAAACGATGCTCTATTGTGCCGAATCGCTTGTTGTTTAGCGGCGTTTTGGGACTAAATATTTATTTACTTATCGTCTTGTTTTTCATAACTTTATAACTGTTTAAACAAAATCGATAATATTTATTTCTAATACGATTCTGAAAATTTTGAATTCCAAAAAAATTTCGGATAATTTTTGATTTTATTTGGCAGATTATTTCTGATAGAATTTGAACACTCTCTTTGGCCAAAGAAATTCTGAAAGTTTTGAATTTCCCGCAAAAATTGAATTTCTGAGAGAATTTGAATTTCTTGCAATTTTTATGTGCAAAATCAATTGAAAATAAATGTGGTCGCCAAAACATAGAGAAAACTCCCGGCCACCGATTTTTTTTTCGCAAATTTTCCACCGCATTCTTTGCTGCATGACTGCCAAAAATTGGCGGCTTTGTATTCTACAGTGTTAATTCACAGATGGCCGAGTTTTCTCAGTTTTTTGCACGGTCACAGGCTTCTAGTTTATTATATTCATCTCCGCGGCGCGCGCACCGTACTTTCTCTCTACTCTCGGATCGTTATCCCTCTCTTCCAACCAACGCCCTCTGCGATTGTGTCATCATCTTTGCGATTTGTTCTGGAATCCCAATTTCCGTTTGGCTTTTCAATACCCGTGCCTTATTGGCTCAGGAATTTCTGGCCCGGAAATTTCCGGTCTACAATTCGGATTATTAACCATTTCGAAAAAAACATCCTTTAAATTATTTTTATTATAGTGATAAACGGCGGTGTGATTTTTTCTCGCTGGTGGGTCCTGGCACGACTGAAACTTTTCAGCTATGTAATTACCCAGCATTGCTTTAGAATTTAAATTTGCCGGCAAATTAGAACTGCAAGATTTTTGTTAGTTTTTAATTATAATTGTTTGGGAAAAGTACAAACTCATCTTTAATAAAACCCACCGTACTCCCATGTACTGCAGCCAAGAGACATAATTTGTTTCGTGCCAAGACCCATTTTTCCCTCCCTTTAAGAACTAGAAACCCCCTTGTTTACAACTGAACTTAAAATCGAATTAGTTTGTTCGCTAAACATGTTTTTCGCGCGAAATTTCGCTTTACAAAAAAGTTTTTCTTCATTCCGTTCGGTCGGCATGCGCCTTTAAGTGTAACTACTATTTTTGAAACCGACATAATGATAGAAAAAATTAGAAAATATTTTTAATTTTCGGCCGGAATATCTTCGAAAAAAAAACTAAATTTCATGGATTCTCAGTAAAAATTCACGGAAATTAAAACTTGCGTAGCGAGACCTCAACTATCACATTACCTATGCGCCTTTAAAGCTACCCTAACCCTATTTTTAAAAATAAAAGAATTTCCTTTTAAAAACGCCGGATTTTCTCCGTCTCTTTTCCCATCTTTTTTCATCTTCGGTACCCATCATATGTAGATGAGAATATCTCTGCACCTCTCCAACCAACCAAGTTCAACACTTCGATGCACCGTCCTTCAACGATGTGATCTTCCTCCTACTTCGACCCCCTCAATTCATTTCCGATTTCCTCGGATGTATTGATCTTTTTGCCTCTTTTATTTCTACGTTCTATAAAAGGATATAGCCAAATGGACTCAAACAATTACAATCCAAAGTTTTGACGTCAGTGAGCTTACTGCGAAAATCTGAAGAGATTATGTGAGTAAAAAGCGGCGGAAGACGTAAAACATATGAAATATTTTTAAAAAACTTTGTTAAAAGCCCCACATTTTCGAGATAAATCTAAATTTTCAAGTTTGTAGCAGCAAATCGCTAAGCAAAGATATATATTTCAGGCCGAGCAGACATAACAAAAATGCCGATGCTTCATCCACGGCATCAATCACTTATCGATGGCGATCGCCGTCACAGCGTCGAGCTCTCGATTTTTATTAAGTAATTTGTTTGCCTGCAACTCAGACCAACCAAATGCTTACGTCGTCTATTAGATCTTTCAACGATATTTGATTAGAATCTGAGAAAAAAGTATAATGGGGACATAATTAATAGGCTTATGGATATTATTTGATTTGACAATATGGATTTTCTAACCAAATATGGTTAAATTCTAATCCAATATGGAGCAAATCTAATCAAATATGGCTGAGATCGTGCCATATTGGATTATTTCGACCATATTGGATTAGATTTGTTTCTAATGAAATATGGAGAAAATCTAATCTCAGCCTTCATGAATTTCTAATCTAATATGGAGTACAGCAGCCTAATATAATGCAATATGGATTTAAAAAATATGGGTGAAGTCTCGTTGAATATTGTTGAAATCTAATTAGACGACTAAGCGTTTAGAGACAGAACTGGAGTTGAAAACCTTAAAAAAATGGGCGTAAAATTTTCAATTGTGTGGAAAAAATCAATGAAAAACTCAATCGTACAGTAATTCAAAAATTCGTTTCACTACTGGAAAAAATCAGTTCCCATTGAAAAAAGAAAAATCAATTTTTCCAGCTCTCAAATGGCAGTTGGGGCAATTCGAGCACTCGACCGTCTTCACCATCGCCGCCTTGCTCTTTCTGCTCGTCATTGTTCAGCTTTTCGTCGCGATTTTCTACCAAATGTACGGAAATCTTCTCATCTGCGACCGCACATCGTCATGCAGGTTCTGCTCGTTTTGTGCTTCCTGGCACTCACATGTGCGACGCTTTATGCGCTTTTCACGGTGCCACGTCTCAGGTGCTCGTCGTGGTTACAATCCGCAAATCGCCGCATTCCCTGGTAAGTGTGGTAAAAAATGAAGTAGATTTGTTTCCTTTGGAAATTCCTTCTTTTTCCTCAATTTTTCCTCATTTTTTTGCTTCCAAAAAAAAGACCCATTTTGCGAAAAAAATTGTTTTTTTAATATATGTCTTTTAAATTTTCCAGACAATTCTCCCGGCGCCAATGATCACAAAACGTGGTTTCCGGATTCTTAGTGGGCCTTCTCGTCATTTTCGCAGTCTCCTACATGCTCATCGCTGTGCTGAATGTGAGCTGTTCCCATGGCGACACCCATGTAACTTTAATTTTTGAAGACCTGGTGCAGTCGTCATCTATAGTTACCAGCTTTTGAGCCAGAATCAATCTTGTACGTCGGTCGAGATTGTGCGCCGAAGACACGATTCAACTCTCCCTATATCCCAATAAATCAGGCCACTGATTTTTAGTCTATATTGTGTAACACACCATTTGTTGAATTTTTCTCGAAAAAATCCGGTAAATTTTTGAGTATACATGTCCCGAAATTCTTCTTTTATCACATGTGTCAGGCTTTAATTTTCTTACTTTATTTTCGACTTCTGTACAAAAATCTTTGATATATTCTATTTATTCTTCTCAATTAATAATCACACGATCCATCTTTCCACTCGTCTCGCCACCTTTGCATCACATCTCGACAGTCGAACTTTGGTTTTCCCGTTTTTTCGTTGACTTTATAGTGTAGCTGGCACATCCATAGCGCAAACGCCTCGCGGCTTTCCACTTTTGGCGGCGATTCATTCAGATCTTTTATCTCTGTTGGCGCAGAAATCGCAGGGATATGTCTGAAAAATTTAGGCGTTTTTGTGTGAATCTTGAGCTTATTAGCTAACTTTTCCTAGAATAGAAATGATAAACTTCTGGCTCGATCCTTATCGTCTTGTAGGTTTTTCCCGGGTAGCGACATTGTGTGTAGCAAAACGCTTCCACATGGATCGCTATGCCTGAAATTTGAAATTTTTGGTGGAAATTTGAATTAAAAGCTTGAACCGAGCTCATCCTTGTTTCCTCTACTGGACATCCGTGCAATTTCGCTCCTGTGCTCGTGCTCGACGTCGATCTCGGATTCTGCAAAGAACTGAAATAATTGAGATTTTTTGCTCTGGAAATCTAGGTAAATCACATTTTTTCTTTATTTTTTCATCAGAGCCATTACTTCTCTGCCTTTTCTTCCTATCCTCTACACTGACGCATGCACGACACGGCTTCCCTCCATGGACCGATTTCCATTCTGAAATTTTTTAAGCACTTGGTTTTAGTTTCGTCTTTTAGAAGCCGTTTTAGGGCGTAAACTTATGACACTATACATAGACTACGACAAATCTATAGAAATGCATAAAAGATAGGTGAAAAATGTGAGAAATTGCGCAAAAACGCTGATGCAAAAACGAAAATAAATTAACTAAAAACATGAAATGCAAGTGCGCTCCACTGACACGCGTTAGAGAGCGTAGACGCAGAGAAATCTCGAAAAGATGAGGGATATCGTGGCGCGCGAGAATCAACCTTTTTTGAATTGTCTTGATATTAAAAGCCCAAAACCCTAATAGATCATTTTTGTTTTTGGTGGATTTTCTTGCTATGCAATGTAAAAATTTATTATTTGTTGCATCTAATCACTTTTAACAGAGATTTACAATTTGTGGCTGAAGGAAAATCCTTCAAAAATCAATTTCTACGATCCAAAAATTCGTTATTTAATTTTCCGCCCCGCTGATCAACTAAATTCTTCTATTTTATCACTTTATTGAAAACCCTCGCCCACCTCATTTTATCACCTGAAACTCGTCACACTTTACAATTTGTGAAATATGCGAAAATGGTTACTCAGCTAAAAAATCTGAAGCACGCGATAGCTTGCGACAACTTCTGGGAGTGGGATGGAACGAAAACGGCGAGAAAGGCAAATTTTTGGTGGAATTTAGCGAAAAAACCTGATATGTTTTTTTGCAGAAAATCGTCGCACGAGGTGCTTCGGAGCTTCTCTAGCTCTGGCCAAGAGCGGAGTCATTAAGTGAGGATAACCAGGAGATGTAGGATTTGTATGATTTATTTCTGCGCGTATATTCAACTTAGCTAAGAAAGTTTGTTTTTTTTTTGTTAAGAAGTCGTAAACAACTCAAGGAAATACCGTTAAAAATAAGCATTAAATAATATAGAGGCTTATGAGAACAAAAAATTCCAGGAAAACGAAGAAGCCAACCAACAATTCGAAAAAGAACGAAAAATGGGCACAAGACGAAGCGAAAAACCAGTCCCAACTCCACTGTTCGGGAGCTAGCTCAATACAAGATGTGCCAAAACGTTGCTGTCAGCAGGGAATCGATCATCTCAATCAGGTGCCATGATAGCATATTGTCTGAGACTACTTGAACTTCCAATCACAATCACCGAGAAAAATCGCACTATAAACGAATATGATCCAACGTGCTCCTAATGAGCTCCAACTCCTCACAGCGCCATTGAGCCGAGCATGCTCATTTGAGCAGCTTATGAAGAAATGGATTTGGAGCCGTGTCGAAACTTCCGCCGATATGGGGGCAATCGCGAGAAATTATATGGAATTGGCGGCGAACTTGCTGGAAGACGTGGATTCACCCACGTGGTTTTGAGAAGTCGCCTATTGACCTGATGGCGAAAGTGATGGGAACACTGAAGAAAAGTGTGGAAATGGATATCCCAAACAATAGTGCGTGGATATCTTGAAATAATGTTCAAAAAATTCAAATTGGCTTGTTAATGAATTAGGCTTAAGCTTAAGCTTAGATTTAGGCTTGCATAGGCTTACAAGTGCGGAAGTATTTCATATTCCCGGACTACAGAATGAAACCTATGTCATTTCGAAGGAGACTCTTTAAGTAGGTCCCTTCAAAAAATTTAGCGGCAGAGGAGCACTTTGACCTGGAAAAAAGTCGCTCTGAAAACTTTTCAGTGCATTTTATCACGGTCTTTCGAGGCCTGTAAAATGGATCCAAATGCGAATTTTTGTAGATTTTTGAAGATGTCTAGGATGCTGTCGCAGAGCACTCGGAACATTTTTTTTGGAATTTTTTAAAATTTTCGAACTGAAATTTCTTTTACTGTGAATAAGTCCATGGCAAAATTTTTCAGTGTATATATATATATATTTTTTTTAATTCAGAAAAGTTGTCAGTTATTTAAGATCAAAATGGGTGTTTTTACACAATGAATATTTTTTTGAGATTTGATTCGGACCTGCAAAAACCAATTTTGGAAAAAAATCGGCGTTTTACCCGGACTCGAACCCCAGTCTTAAAATATATTAATCAAACTCGCTAACCACTCGGTCATTCATCGACAATTTTTCTTGTAAATGAAATGGATGACAAAAAAACGTGACTCATTGATATCTACTTAAATATATAGGGACGTGAGAAATAGCTTTGGAAAAGGAGAGGACGAAGAGAATTCAGAGAGACTTTTTCCAGTTCAAAGTGCTCCTCTGCCGCTAAATTTTTTAGTAGGGGCCTGCTTAAAGGGTCTTCTTCGAAATGACATAGGTTTCATTCAGAAATCCGGGTTTAAGTTCTATTGAACTACTTCCCTGGTTAGGCTCACTAGGGAGTGACCAGAATAAATCGATAAAAAATTGTATCGGAAAGCTGGCATTCTCTACTATAAGAATATGAGTGTTTGCCCGTTCGGGCTGGAAATCTGAAATTTTTACGTCGGAAATTCTACACTGAAATCAGTGCTTCCTATGGTTAACAGTGGATTTTTGTCTCTGGAGCCAACAGAAGTCTCACCACAATGGTGGAAGGGCGAAATCCACATCGGTTCGGTGGTCGAGCGGTGAACGCGTTCGCCTCTTGAGCAGGAGTTTGTGGGTTCGGCTCCCATAGTCATGGGTTAACTTTTAGCCTTTTTTATACAAAATTTTCAGAACGGGAAACAAGTATTTAGAACATTTTTTTGAGGGTTTTACATAATTTTTTTGCTTTTTAATTGACCCATAATTACCCAGGAAACTTTTCAGAAATTTTAAATTTACATTTTCGAAAATTGACTCTTTTTCCTCCAACTCATGAGAAAATATGATCGAAAAATTTTTTTTTGAAATTTTTTTAAAAATGCATGGAATATTTTAGAGTGTCACAAATACCTATTCATTATTACGTTTCAAAGACCAATCATTGATTTTCTGATGCCTTATTAAGACGTTTTACCAAATCGATCTTTCAGGCAAAACATCTTGTATTTGAGGTTCCATATCTCTGCAGTAAAAAATCGCACTCAAATGTGATCAACTAGAAACTTGAGTTAAACACAATGTGATCTAAAACATTTCAGGGGGTTGAACACTTTTTTGTAAAAAACTTCGTTGCCGAGTTGGAACCAATTGATTTGAGATTCACTTATTTTTGAATATTCAAAATATTTGTTCTATATCTTGGCAACGAAATTTTTTACAAAAAAGTGTGCAACTGAAAAGTTTCAGATTACATTGTGTTGTACTTAACAGGTTTTCAGTTAATCACTTTGTAGTGCGATTTTTTCCTGCAGATATATGGAGCCTCAAAAACAATGTTTTGCCAACATCGATTTGGTAAAACTTTATTTCATTTTTTTTTTTCATGTTATTGTTTTTATATTGGGTCAAAACGTATTTGCTCTGCTATCACAATAAGCTGGCGCTAATTTTTAATTTTATTATTTTCATTTTGATAAATTTCACTGAAATTGTCACTTTAATGGTTTACATTCTATTGGTTTTCTTTTATTCAATGTCTTTTGATCGGAAACGTGATGTTTGCCTTGCATGACCGTCATTTTCCTTCCCAATCCCCTCCCATCAAATCCCTCGATTTCGAGACATGAGCAGAAGGTGGCAGATCATTTGGCAAGCATTATAAAGGAATCTTATCTTATGTACCAGTGTGGAAGAATCCGAATTTGGTTGAAGACGAAGAATATGTCGATTGGGAGCCAGAAGTTTTCAGTTGAGGTATGTTGGTTTCGACTCTATTAATTGTCATTTAAAAAACCTTTCAACCGTATGACTGTGTGTTGCCGGATCAAGATGATGTATTGTTCGGTGAGAAAGCTGTATCAAGGGAAGAGTTGGTTAAAGACGTGCGATCACCGTTCTAGCGTAGAAATTGGAAGTAGGCCGATAACGACTCTGCACCATAGTTATCGCTGGATACGAACCGATGCTCATATGTACAAACTGCGGAAGTACGGGAAAGATAAAAAAGCGTTCCAAGAACGGCTCGTTTGGCACAGCTTACACAGGCTTTATGGCCTTAGGAGGTCAAGGTGAAACTGAAATGGTGTACATTAAAATAACAAGTTTTAATATAAATATTTTAGGGGTCTTTGCATGATTCTGGTTTGATGGCTACGGGACTGGAAAACATCACCCGCGAAGTGAAGTTAAACAAAACGAAATGAAGTTGCAAAAAGGTCCGTCACAAACCTGGATAACCCGATGTAAGCAAAGCCACAGGAATGTAAGAAATTGCACTTGTATGTTAGCTATATATATATATATTTATATAATTTCGGAATCGTGAGTCGGAGAGTCGTACCAAGTACATGGAAGTGCCAGATCAATAAAGACGCTAAAAAAACGGGATGATTTTGTCAAGAATGCCAGAACAGAGATCTCAACCAACTATCACCCGTCGATGGTCTTCAAGTGTGAGCAAACCGGAATTCAGAAGGAGCGGTATCCAGCTCGGTCATTAGCCCTTGATGGTCGAAAAAACAGTCGAGATGTTGGCGCACCTCAATCGAAATCGTCGCTGACCCACTCGTTTACGTTTGTCCCGATGATTTTACTCGATGGCTCAATGGGACCCCAAGTTAAGGTAATCGCTGATCGACTAAAAGGCCAGTTTCCTCCGTCTACGTGGTCCAATTCAAAACTGCCCCAATTTTGTGCGGGCTGGATACAGACACACATCATGACGAAGCAATTGATGTGCGATTTTTTCGAATGTTGTGTCTTCATTCCGTCTAATGTGACCGAAAAAACTGTACATCATGCTGGACCGGCCAGCGTTCAAGGACCATACACAAGAACCTGGTTCCAAATGGTCATCATGTCGTCATTCGCAACATTCCAGAGCACACAACTGGAGATGATCCAACCGTTGGATGTCTATTGGGATGCGCCATGGAAGAAGGTATGAATTTTAATCTTTATAACTTTTTGAAAGTATTGTCCAGAGCTGGTGAGCTGCTCAAGAAGTTCACAGCATGCATGCCCTTCGAACCCAGACGGATTACGTCCTCGAGGAACAACCCAATTTGCATGGTATCTGTGTTGTATCTCCAGATCTCGGCAGTGCACTTCCGACCGTTACAGCTTGAAATCGTTGGAAGAAAGCTGGATACGTGGGTGCTGCCAATACTTCATCAACCGTACCACTTTTTGACTCCAGCTCATGCCATATTCCATTGATCATGGTGACCCAGTGATTTGCTATCACACTTATGGGATGTAACCATCACGGAGTCATCCGATGCGCAAGATGCAAGATGTTTGTTTGTTCTTCAACCATTTTGTGGTAACAACATCTTTGTTCATCTCCTGAATAACTAATAAATTCATGATTGCATTACATTCAAGTTTCGCTATGACTAAAATTGTTTATAAGGGGATACATGGTTGTAGTGGTCCATGGTTTAGTTTAAATTGGAAAAGATGTTGAATGAATCATTATGGTCTTGGTCGACACATAGATCATGCTGATGTCGATCAGAAAAATTAAAATTTGGGTTTTTATAGTTTCGAAAAAACACGTTTAAATTTTTGAAAAACTTTACCGTTCTTTAGGGTGTAATTGAACTCCAGATCCCACCATGCATGTCATCCACTCAATAGCCACTCGGCCATCTCCTGTTGCAGGCAGTACTAATTGGGGAGGTTGATAAGTAAAGCACGTCCGAATAATTTCAGACGTAAAAATATCAGATTTCCAGCCCGTACGGGCAAAAATTTCAGTCATTACAGCAGAGAGTGTCAACTTTCCGATACAATATTTTTTTTTTGAATATCGCTCTGCCATTTATTCTGGTCATTCCCTAGTCAGGATCAGCTCTACCTCAGGCCTAGGCTAAGCATAGGATTAAGGGTAGGCTTTGGCGTAGGCTTATGCTCGACGCTTAGGGGCTTGCTCAATCATACATCTTGCTTAAGCACGCAGCTTAAGACAGCAAAGCTTAAGCACACAGATTGGGCTTAGGCTCAGGCTCAGGCTTAGAAACAGTCGAAAAGTTAACTAAGTCAAAAAATTTTTTGTTAAAAAATTGTTTAAAAGGTATTATGATTTTAATAGAAAATTGGAAAAAACCCGAAAAAAAATGAACATAAATCAAAAAAAAAATTTTTTTTTAAAGAAAACTTCTTTTTTTCGAAAAAAATGCAATAAGGTTTTTCTGAAAAAAACAGGACTTTGATTTTACTGTAAAGAGAATTTTTTCTGTTTTCTTTTTCCAAGATTTCAACTTATTTCTGCGCTTCGAGTTTTTTTTTCAAATTTCCTCTTATTACAGTTGGTTACTGTCGAAAATTCTCGGTCGTCCACATTCATGACAATATCGTACTGGGGTCTCGAAGCGAGAGATTTCATTGTTCGTGAGATTTCTCACAGGTAGTTTGTCCAACTGGATATCAGTGGCTCATAAGATGCAGCTGGAGAACAGTCCTTTGAGTTTTTTTTCGGAGTTTGCAAACGCGCCCTAAAAAAGTTTGGAAAATTCCACGTGGAAAATAGTTTGGCGAAAGTTTTGATACAAATTTTTCGTGGATTAATTTTTTTACTGCTCGAAATTCTCTTTTGTTAAAATTAAAAATGTTTTATGGGCGAATTATTTTTCTAAATTTCAGCTTTTCTTTCACCAATAAAATATTTTTTTGAAATATCGCTTCGAGACCCAAAAAAATAATTATTCAATGAAATATCGAAAACAGCCAAAATCGAGAAATTATCGAAAATAATTCGAAAATTGGAACTTTTTAAAAAATATTTTAAATTTTTTTCAAATCAACACAAAGTCTCTCAACTTTTTTCTAAACAAGAAATATATTTCGTGACGAGACCCATTTCTACTAATTTTCTTTTTCAGAAATGCATAATGCGTCCATTGGATTGATGATCTCGCTTGCCATGATCGAAACCGTACACGGCCACCGTACCATGAACGAAGTGACACGTAAATATTCGAAAACTCGCGAAAACCGGAATCCAAGAGTCTCTGAAATTGGAGCACGTAATTTCTCAAGGAGTTCGACATCGATTCTCTTTCCGAAGAATGCGTGAGAGATCTGACGAGATGGTTGATGGCCGAACGATGACTTGAACAGCCGTCTGCGGCGATGAATGAATCGTTTGAATTGACCGTTGATAGCAGTAGTAAGAAGAAGGACGATGCCACGTTTGTTAGTGCGTACATAGAATTCTACCAAAAGGAGATCTACAAATTCTAAAGAAAATCTACGAAAGGAGTTGTCACGGCGCATGCCAGATCGATCTTTTTTCGGCTCAAACTTGGAAAAACCTGCAATTTTTATACATTTTTGGCTTCGAAAAGCAGGGAACTCTGCAATTTTAGGCCTTTTTCGCTAAAAAATTGGAAAAATCTGCAATTTTTATACATTTTGTGGCTCACAAACTGGAAAAACTTCCAATTTACATCTCAAACAGTCGGGAATCCGCAATTTTCCTCACATTTTTAGCTTAAACTAATTGAAAACATCTGCAATATTTCAGATTTTTGGGTCAAAAAATCGGGGAATTTTGCAATTTTTACATATTAAGTTTAACAGTGGAACATTGCAGAAAATCGGCATAATGTTGAACGTTTTCCTTTTTCCAGTTTTCTGTTTTGTTACGATTTTCGTTTTGCATGGAAAATGCTTCGATTGATACCCTTCTTTCGGAAACTAACCGACAGGAGTTTCTCCTGAAATAGGCGTAATCTCAAACCATTTATGGGCGTGGTCTTCTCTCTTATGGTTTTTATAAATGTTGTTCATTAAAACATTTTCAGGCCTTATCAATCTCTCCATTGGCTCGACGATTTCCGGAAAACATAAATTGAACGCGGGATGGTGTAATGCAAATCCTGAATGAGTTGCTAAAAAGTCGACGACTCGAACCTACCTTCACGTCACTAAAAAAATCGTGACAATCCTCTGGGAAAAGCGAAAATCCAACTGAGCCACTCCGTACTGTGTTCTGCTCTACTCTCCACGTCGTCTGCCAGGCCGATGTTCGATTCGCTCATCGGAAAGTGCCGACAATCAACTCGATTCTTAAATATTCGCTGTCTCTAATGCCAAATGTCGCATCTCTTCCTAGTGACGCTGCGTGGTCCGAAACGATTGTCAGATTCAGGACAGTATCACCGAGAGGGTCTCCGTAACACGTGGGATACCGTATCCCGAAACCCGCTAGCTCCGGCTCATAGTGCAGTGTTCGGCTGATTTCGGCATTTATCTCCGTTACGGAATTTGATGAGAATTCGAGATTCGCCAACGATGAGAGAGTTCGGAGTCTCAATGGAGGTAAGTCACTTTGCCACGTGGATGGATTTCCTTTAAAAAGAGTTTTTGGAAAACAAATCAGATTTTTGTATATCACCTTTAAATCGAGAAATTCTTGTTTTTCTGTAGTTTTCGAAAAGACATAATAGAATGGGTATTGCGGGAACTCCGGATGCACATAGTCACAAATTACTCTTCAGTTGTGCCTGTATCATCCAACGTATGGTACTGTTTCAGAAGCTTCTTCTAGTGTAGTTTATACCGTAGGGCTTCCAATTCTGGTAGAGGCGCGATTTCAGGGCCTGACGCCCGCCTGGAACCTGCTGACCTTTCGCCTCTTTTCTCTCATTGCTAATCAATTTGTTGAAAATCAAACTAAGAATTAAAAAAATAGTTCACGGAGCTTGTTCTGTCGTGGATTGGGGCGAGGGGCAGGTGGTGGTGATCTTAAGGTCAGGTAGGCAGGTGTCTTTTCACGCCTGCATTGAAGTCTAGTACCCCATATGCCGAAAACGCTGAATTTTCTCATTTTTCCAGACGACTCCCTGCTTCATAACTCTGAAACTAAGTAAATTAGCTTGCTCTCCAGCTCCTCCCCATCGGCTCCAATAGCCCTCCGAGGGGGCCACTTCTCGAAGAATTGAAGAGATTGGGAGATATGTGCATGGCTAATCTCAAGAGTATGTGAGCCTGTCGTTTTTTGATTTTTGAATATTTAAAAACCCAACATTTTCAGCGACTGATCACTCAGCCTCATTTGTGCTATGCCACGGATTTGCTCTGAAGTATCTGGATAGATCTTATGAGATTAGTTCAGCGGTTTTTTTTTCTAATTTTCGAAAAATTTAAGAAATTTTAGGAGCAATTGAAGAGAGAATTTGAATTTTTAAAAAATTTCGAATTTATGGAAACAGTAAAGTTTTTCGGAGTTTTTAAACGAATTTTCAGAATTTTGTAATAAAAAAATTTTCTAATTTTTATTCCACAATTTACAAAATCTAAAAAACTTTTTAGAAATGAATTGTTTGAGAAGTTAGATTTCCTAATTAAAAAAAAATTTGGGTTTTTATACAATTCTTAAAAGTTTGATATTTTCAAATGATATGAAGTTCACACATTTTTTAAAATATTCAAATAAAGAACATTTTCATTTTTTTGAAGAAATGTTCAAAAATTAACATTTTTTGAGACTTTCAGAAGTTTCTTCTGTTTTTTTTGCGTTTTCAAGTTTTTTGCAATTTGCGTAATTTTTATGGGGGACAGAAAATTTTGAGAATGCGGATTGCACAACCTTTTTGACGCGCAAAATATCTAGGAGCGAAAACTACAGTAATTCTTTAAATGACTACCGCTAAAATTTAGCATAAAAATAAAAATATATCGATGTATCTAGGATCCCGTAATAATCGACAGTAGCGCGCTACAGTAGTCTTTTGAGACGAATTACTGTAGTTTTCGCTATATTTTGCTCGTAAAATGTGCACGAATTCTTATGATATTTTGTTCTCACAAAAGTTGGTCAATTTATGGGATTCTCAAATTTTCGTTTTTTTTTGAAATTTAAGATTTTTAAGATAACATTCTTCAAAAAACTGATTTTTCTCTTAAATTGAAAAGGTTTTTTGAAAATGTACAAAAAGCTCTACTGATTCAAATCATGGAAGATAAAGAAAAAGACGAGTTTCTCCAATCTGCTCGCCATTTCTCAAAATGGCCTCAAAATCTGACACTACCAATTCAAAAACAGACACTAAATTGGCATGGCTGTCTTTTGCGAAGCGCTTGACAGCTCGTCGATCTGGTCTGTCAGTGGAGTGACCGACGATAAGTGCTTGTCGAGATGCTCGCCGAGCTGGCTGCCACAAGCTCTGAAATTCTAGATAAAGTTCCAAAATCGATGCCATTCAACAAATTCGTCACGGAGAGGATAATGCAGAATCGCGGTGATTTGTATGTACTGACAATTCGAGAAATATTCGTTTTTGCGTCTCGTTTCGGATAATGGCTACTAGGATGCTTATAACATGAGTGTTTGTTCTTGGGGATTGCCACGAAAAACTGGCAAAACGTTTCGAAGATTGAAAAAATATTTCTTGCAACATTATAAAGGAATTCCCATTTATATAATTTTGGAAAGTTTTTAGATTATATTAGGTAAAAAATTCGAATTTACAAAAAATTATGAAATTTTAAAAAAAAGTTTGAAAATGTATTTTTAAAAAATTTAAATATTAGTAAATATTTGAATTATCTAAATGTTTGCGATTGTGTTTTAAAAAAGCTTAAATTAAAAATTTTTTTCACCATATGAATAAATTAAAAATATATAACAAAAATTCAAAAAAAATTTTTTTCGAGAAAATTTTTTGCTTTTTTTAAAAATAGAATTATAAAAAAACTGAATAAAAACCTTCGAAAAAAAAACAATTATTTTGAAATTTTCAAAAAAACTAGCAAAATGATGTTAAAAAATTTGAGGAACAAAATTCACATCCCTTGCAGAAACGAAGCCGCCCAACTCCTAGGAGATGGTGAAACAATCAGTGAAACCGATATCTTCATGAAATCGAAAAGCGAATTACTCTTTCAACGTGTATTCGTAATGTGCCGTTTCCGAAGCAAGAGTAGAGCGGTTACACACTGGACCCCTATACCGCTGGGGAGCGGCCAACGTGCACAATGTGCTAATTTAAGCACGATCACATAAACGTCGAAATCAATCAGGAATTGCTGGAAAAGTCGCTATTTTTCGCAGAACCGTCATTGTCCGCCACTTGTTACGGCAGAATGGAAAAGAAGCAGAACCTGATGAGACGTGTCACTGCCCCTGTGCTGAAAATTGTGATGAAAGATGAAAAGTTGCTGGCGGCAAGGAATTTGGAAAAACTTGAAAAAAAAGAATTTCATCGTATTTTTAAATAATTTTTTGAATGAAAAATTCGGGATTTTTCCTTTTCCGCATTAAAAAAAAATTCAACCTATTGACTTATTCGAATTTAATTCTCAGGTGAATTTGTATTAACTACTATTTTCATAGTATTGGCTTAGAAAACAACAGTACTAAGCCTTAAGGTGAGATACAGATAAAAGAAAAAGAGTCCACGTTTTTATCAATGAAATATTCCTGAAAAAATTTCGGCGGGGTAAAAAGGAAAAGTACCAAAAATCAAACTTTCAAAGCTAACAATACGCAAGTATTCAAGTTAATTTTAATAATGGTTTAAATCCGGAATTAAGAAAGTGGTTCAAATGTCATTTGACTCATCCCTATTGTATTGACAATTGAAACGATTTTTGAGACTTGTATTTATTTAAGGAAAAAAAGTTCAGCTGTCACAAAGCAGGTCGTAATTTTAATTTGAATATTTAAAATAAAAAACTTATATGGGTGCTTCATTTTGCAAAACATTGCATTTAAAAAAAAAATTTTCAATGTTCGGCAAATCCGAGCTTGAAAAAAATCCTTCTAATTGTGTTTCCGAATTTTTGGGATTTTTTCTTCGAAAATAGGAATGGTTTAAAACAATTTGAGTTAGATATTGTTGCATATTTTTTTAAAATCAATCTCTTGCAATCAAAAAATTGAAATTTTAAGCAAAATAATAAAGTTTTATCTAATTTTTCAATTTTCAGGTATGGGTGGCCACAATTCTAAATATGGTTCGATCTCTCAAAGTCTATCAGATTCATTTCAGCCCGAAATCCAACGCGGCGAAGTTCTTGTAGGTTTTGTTACTGCGAATATCAAAATTTTGCTCGTCTAATTTGACGCCTGCTCTGTTTTTTTTTACGCGCATTTCAAATTATCTTAGAAATCCGTGACTTTCGTCTAATAACACCATTTTGTAAAATCTGAGCAATTTTCGGTTTTTGCGCGTCAAATGTGAGATATCTAAGTCAAACTTGACGCGCAAAATTTTCAAAAAAAAAATTCAATAATTTTCCGGGCGAAACACCTCGACATGGAATCGATTTCCCACTGCCAAGCATTGCGAAAACAGACGCAACAAAATAATCTGATCACGGCCGCCAACTTTTTGACACTTTTCGGATGTGAAGCGCTCGAGGTTGGAAGCGCCTGATTCTCAGATTTTGGAGCACCGCATTTTCAAGCAAACCGGCTACTGTGTTGCGAGGAAATGCTCATGCTATTTTTGTAAGCAATGATTTTTTGATAAGAAATTTCCCAAAAATTTTGATTTTTTGAATTATCTTTGTTAACTTCTTATTTTTAACTCAGTCTTTTTGCAAACTGAAAATTTCCAATTTTTGGGAAAAATCTCCATTTTTCAGGCTGAAGAATGTGTCGAACTTGGCCTGAACCACCGAATCGCTTCTCTTTTACGCGCACTGACAACCAGTCAATTCTGCCGAAAAGCTCTATGCGATGAATCTAATATCTGAAAATCGCGTTCTGACTTATCGATGGATTTTTTGATTTAAAAATGAGTGCAGGTTGGTGGAGAATAGTAGGATATGTGGAAAAACAATATTTGAAAAATAAAAAAAAAACTCATTGATTTGAATTTTCAAAAATTCCAAAATAAAGAATTGTATTCCAACTTTCATGAAAATGGCAACAAAAAACTCAAAGTTTCCTTGGAAAATTTTTGAAAGTACAAAAAAATTAATTTCTGAGAATAGTTTCAATATCAAAGTCGAAGTTTAGTTTGAGTAGTGTTGTCAACAATTGCCTATTAGAATAGTTGAAAAAATCTTGGAATTTACGAAAAACAATTTTTAAAAATTTCTCCGTCCAAATTTCGAAGCAAAAAAAAAGTCTTCTAATTTTTGACATTGAACAATTTGGAAATTTTTTGAATTTTCAAGAGTAATTTATATTTCGAATATTCAGAACAGTTCCAAAAAAAAAGTTTTGGATTTTTTTCCAATTTTAATAAAATTTTCAACACAGAAAGTTTTTTTTTAATTTTTTAAATTTCAGAAAAAAATTAATATTCATAAAAAATTGAAAATTCATCCATTCTAAAAATAAGTTTTCACATTTTTCCCAGAAATTGTGGAGCTCTGCTATGACATGAATACTTCGGAAGGATCTTCTCCAGCACCACATCAAACTTGTTGCGGCTCACCAGTTGGAGCACTTGAGCGTTACGAAACGAGACTCGTATTTTCTGTTGAGAAATTTCTGAAATCTGGAATTGATGGTATCGATTTTGAAGATTTAGGTTTACAGTCGAGTTTTATAAGCCGTTGAACGAAAATTTGACAAGACGCGATCAGGAGCAATGAGGCGAGAAGTAAGGCCGTGGAATATAAATAGGTGGCCGAGTTTTTTGTAAACTATGCCACCAAACTTGGTTTCTCCGTTCGTGGCCACAAAAATTTTGAATTTTTTGAGCTTCTCTTATAATGCTTAAAAGTGATTGCAAAAATTCATTTCTTTAATTAGAAAACTCCAAAAAATTTGAAAAAAAAATGTAAACTCAATAAAAAGTCCAATTGTTTCACATTTATTCTGGTTTACTGAATTATCAGATTTTTTCTTCAATTTTCAGTTTTCGACTTTTCAAATTTAAAAAAAACCAATTGTTGCCCGAACAAAAACCATTAAAAATCGACAGTATGTCATCCAATTGGGGTACAAAAATTTTAATGTCCAAATTTTCATGACGAACGAAGAAACCTCGTTTGGTGGCCTAGTTTCCGAAAAAACTCTGTCACCAATTTCTTTCAAAATTCAAAATTTTAGTGAATCCCAAAAAAACGAACATATGCGGCGAAAATTTTTCAAAAGCTTCCGAACAAAATCTAAAAACGTTCCGAAAGTTCTGGGTAATTTTTTAAATATTAAAAAAATTCATCATAAAAAGGGCGGCAGATAGCGGTTCAGTCGGTAGTGGTGGCCGCTAGCAGTCTGGACGAGTCAAGTCCGAAGCCTCACCACCTAGGTTCACCCAGCTTCTATTGGGAAGTGGAGCAATCCACGACTGGATTATCGGCCACCCGGCTAGGACGTGTCGTGCATACAACCTAGCCCGAACCACCAGGCAGATTGTACCAGGATCCCCGATCCGATCCAGTGCAACTTGAAGAACGGGTCGTCCTTTAAAGATTCTTTCAAAACTAATTTTTTACTAAAAAAAATTTCCAGACATTCGTCGACAGGGCTTCCTTCTCAACAATTTGGCTCCAGCTCTCAATCGCTTCGTCCCCAAATTCTACCGATTCTCGCCCGCTTCAAGCACATTTCCCCAGCGGGGACTAATTTCCCCGGGCACAGCCGCCTCATATTTCGACAAACGAGATATCATTTAACTTCAACATCTACGATTTCATCTTTATTAGATCTAGAAACGAGGTATGAATATCCGAAATCCATGAAGCAAGGCGAGTATCCACGTGTATTATGATTGACGAGCTACGACTCGAGCCATTTCGTTGCTGATAGAGAAAAAGCAGCTGGGCAAACTGAAATTGCAGCAGAGAGTGAGGAATGTTTTGTGCATTTTGAGCCGACTTTTGAAAGATCAAGCTGTGATGGGTAATGAAGATGAGACGATTATCGATCCGATTCTTTGTTAAGGCAATCACCAAAGCTTGACCGTCGTTTTTGTATGTTTTTATACGACGGAAATCACTGAATTTCATGTCTATGCCGAAAAATCATGAGCAAGTATATACATCACATGAAAGAAAATAGTTACAGGGCCGGTTTTTTAATTTTTCTGTCATACCGGCAATTTTGAAACTACTTTTTGAACTTTTTAAAAATTTGGGTAAATTTGGCAAGTGCAAATCTCTGTATCGATTTGTCAGAATCATAATAGTTGTTTTAAATTGAACATCGCGTTAATGTTTTTAGCATTTTATCTTCGAAGATTTAATGTCTCGCAGTTAAAAATACATCTTTGCAGGAAGACTCCGCCGCGTGCATCGTACCATTTTTGTTCAAAATTTGCTCATGGGGACTTCAAGGTAAAATACGATAAATGTGTGATAAATTTGCTGGGATGTCTTTAGGGAGTTCATGCAGGTATGATTTTTCGTCGGAAATGACTGGAACGCGTTTTGTTCGCATCAATTCAAATTTAATGTAATGGCATTTGGCATATGAAATGTCGAAAGGTGCTGGGAATGCCGAATAATATAATTTGGTATGGAGAGCTGAATAAACTAGACAAAGTTCAAATATTCACAACACTGGGGATTGCTTCACCCGTGACCCGTTTAACCCGTTCACCCATTTTTACAAGGGAAGGTTCTGAACTCGTTATCGGACTTTACGCCCCACTATATTCATTCGATAGAGAATGGTTACAGATGATCCTCAGACTCCAAATTTAGCTGCTTCAGAGCAGGTTCGACCAAGTTACGACACTTTGAAGATGCCGGAGTAAAAAAAGAATCATTGATGCACCCCCTTTGAAAAAATTTCACGATATTCACTGAAAATACCGCTTTTTTTTTCTGAAAGTTGATAAAAATAGTTGAAATCGATTTAAATAGTAAAAAACAAATAATATTTTATACAAGTTTTAGCCCATCACTCTAAAAAAACCCCGTAAATTAATGTACATATCTTGAGCGAAAAATTCCAAAAAGTGATGTTCATGTAGATCCATCTAAGCCTGGAGCCAAGCCTTATGAACTGAAACTTGTATGGTATGACATGTTTCCATCATTTGCAACTATTTGTAAACATTTTATATCAACTTTGAGAAAAATTATTTTATTGAACTTTTTGGAATTTTTAAAAAGGGAAGTATTTTGGCACTTTCAAAATGTCGTAACTTGGTCGAACTGCTCTCAAGCAGCTAAATTTTTTGGGATCATCTTAACTAATCTCTAACTAATATAGTTGACGAAGGAAGTCCGATAACGAGTTCAGGGCCTTGCCACCCTTTTTAGGCGTCTTTACGGGTGACGGGTGACCGCTCGCCCGTTTTTTTTTTCGTTTTAGTTGTTTTCACGGGTGACGGCTGGCTCGTCACCTGTTTTTCAACCGTTTTTGGAAGTTTTCACGGGTTATGGGTGATCCTTGGTTCCGGCAGCCAGTTTAGGTAATAGGTCGTAAATATCGTTTTGGGCCGCGTCTTTACAACTGGGCTGTGTGCAACTGGGGGTGCACTTGGGTTGAAAAGGATCGACCGGCGGTTCAACTTTAGGTAGCATTTGGAGCGACCCCGATAAATAAAATGCCGACCCTGAATGAAAAATTTTAGCAAGGCGGCCATGCTCGTTTAATTTCCATTCTCAAAATTATGAGCGCTCGCCGGACTACTGGTTGAGCTATTGTGAAACGGGTCGACCCTGCTCGACCCATGAGCACCCCTGGCAACCATGATTTTCGGCAACTGGCAATCAGAGTTGCCGCACCCAATAAGTTTCGGCAGCCGGCAATTGCCGAAGCGTTGCCGAACTCTAAAAAGTGCAACCGCCACCGGCAATTTTGCGCAGCCCTGGTTTACACCTACCTGACGACTTTTGGTAGACTAGAACACATGTATTCGAATTCGACAGATGCAGCCGAATGCCGAAAAAAGTATTGAACGACATTAGGCACATGTCCGGGATGGGCGGATACCTTTTCGGATAACCATCTTCACTAAATCAATTTATCAATAAGTATTGATTTAGCTTAGTCGGGAGATACTATACTGACTAGAATAAAGAGTACCTATTGAGCAACATGTTCATATGACAAAAACGTTTAAAATTGTACGCATTCTCCTCGAACCCTGAAACTTGCCGTTCTCTGATCAAAATCGGCTAAGAGAAAACGGACTTGCATACTTTTTATACGGCAAATGTGTAGAATTTTAAAATGAAAGATTTGTGCTATCAAAATGTTGCTCACCAGTTTTTGTTCTCCCGGATGCGCTTCTTCCAGAATTACTACATCAGCACGTATTGATAACTAACTTGAGGTGTTTAATGAAGTTACCCGAAATCCAAAAGTATCCACACCCCGTCATAATAAGCATATTTCATAAGTCAAATATCAAATTTACTGAATTCCGCACACCTCTGCTCTCCATGCTCCAACTAATTTTTATTGCAGAAGACGAAATAGTAGTCCGCTGCCTTGCCGAATTCGTCGACTCTATTGGACTCAACGTGATTGCTGCACGCGTTACGAAGGCCTGAACATTGAGACTCATATTCGCAATTCGGTGTGAAATGGTTCTTCAAATTATCCCGTCTCTTTCTGAAACATGTGGATTTACTACGCATTCCTTCGCGATTGCGAATATATTATTTGACCGACTTTCCCAGGGCGAGAAAACGAAATACAATGATGATTGAGATCGTACGAGATTAGACCGAATTGATCACAGGAACTTATCAATCTTTTGGTGGAGATCTATGTGCCGAGGGTAACTCGGTAGCGTTGTCTTCTCTGCCACCTGCGGTCCAATAGACCGGATGTTGGGCAGGTTATGATTAAGAGTTCAAAGGAATGTCAGTTCAAATTGCTCTCTTCGATTCAAATGAGACGGAGTTGACTATTGTGCAGTGGTGGTAATTGTTTATTTTGAAATTCATTAGAATAGAAAGCAGTTTTCTTGGAATTTTCAGGAAATTAATTTTTTACCTATTCTGCATTACTAGATTCTTCAATTTTTTGAGAAAATATATATTCCTTCGAAAAACTCACGTAACATCTTTTCGTATACAAGAAGAAAGTTACAGTCGACGACTTTAAAAAATTCAGTTAATAAGATTTCAAAAACAAATCGAATTTTTTAATTTGTACCGCAATCTGGAAAATATTTTAAAATGACTCCAAATTTTTCCCTGATTCCAAATATCTATGAGATAAAATTCATAAAATAATCCCTTTTTGATCTTGAAATCGCCGTATTTCACTTGTGCACGCATGAGATTTCGAAGTTTCGCGCCAGAGACCGCATGTGTTAATTTACGAGATTTGTGTATATTTACGAACCCCTTAAGCTTTATCGGTTGCTGTTTGCCGTTTTTCAACGAGTTTTCTTCAGTTTCGTCGGTTTTTGTTAAAGTTTTTGTTTAAAACATTTAAAACTTGACAAAAATGAAGGGACTTCAACTCGTTGAAAAACGGCAATCAGCATCCGATAAGGTTAAGGGTTTCGTAAATATACACAAATCTCGTAGCTAATCGACACATCGGAGTCTCTGGCGCCAAAATTCGAAATCTCAGCACAAATGAAATTCGCGTTAAGCTGAAATAAACCTCCAGGGAAAAACATCCTTTTTCACATAGTTGTTCGAAATCAGGGTCAAATTAAGAGTAACTTTTAAATTTTTAAATTTCTTCAGTGGCATCTAATTCAATGCAATCACCGGCGATAAATACCTGAACATTCAATTCTTCGTTGCAATTTCACGAGTACTCCAAAAAAATCGATTGACCCCATTAAAATTCGTCAATTTACAACTATTCCAGCTTATCTTCGACGAGGCAGTCTGGATATCGAAAAAGCCATTTCTTTGAGCATGCGGTCAATGGCTCCAACAATCGATCAAATGCGGCTTATGATCATGCCAACGCGACGGAACATCTTCGAACCCAATCCGTTGAAGAGCACGTTGTTCGAGCTGTTCGAGAGCTCCGAGAGACGTCAAATCGAAAATCCGGTGGAAATGTGAAGGGCACAAATTAATGAAAAACCAACGAAAATGGTGAAACTAGCCAACTCGAGATGCTCACCGAGAATAAAGCATACGATGGACGGAGCATAATAGAAAAGTTGAATTCATTCAATCATATGTCACAAAAAAGGAAATTTCCTTAATTTTTCGGTTTTTTTTTTCGGAAAAATCTAATTCTATGCAAAAAATTTAATTGAAAATCCGGAGAAAATCGTATACTTTTTGTCGAACCATTTTGTGGGCGGAGCCTAACTAGTAACACTTTTCAATTTATGGCCCATCTCGAACAGAAACGTGAGAAAAAATTCTTCTTTTTCGCGAAAGTCTAAAAGAAAAAAAAATCGGAAATTTTTGAATTTTTCGGTTTTTTCTGAATTTTCCAATTTTCATTCAAAGAAGGTCGAAAACTTTTTCGGCGATTTTCCGGTTTCCTTTTTGAAAAAAAATATAGATTTAAAAATGTGTAGTTTGTAGTTTGTAGTTTTTGCAGTTAATGTCTTCCATTTTGGATAGGCGGCAACAAACCTGCTCGACGTGGGAGCACGAGTGTCTCAATCAATGGACATCTGTCGCTGCCGATTCAATCGATATCGATTTAATACGAATCTGCAAACAACACCTGACGTGTCGGGAGGTCCAATAATGGCGGACATAAAACTACGACAATCACGTGTCCCGTTGATGGAGTGACCTGGCGATTGCCGAATGGTCACTCGCATTAAGATTACAATTGAATATCGTCGAATGATATGGAAGAGGATATTATTTTGGAAGATGCGCAACAAACATTTACAGAATACCACTGGAGAACTTTCTGTAGAGACGAGGTTATAATGGTACATGCGGTCGGGTTGTAGCGAAATAATCATTTTTAAAAATTTGAGAAAAAAATTGTGAATTTTCCGCGTAAAACGTGATTCAATCGCGAATTATTGTATAGATTTTTCCGACAATTCGGAAAAATGCCGGAATTGAAAATTTCCGGCAAATCAGCAATCCCATGGCCGTAATTCCAAATTTCCGGTAAAACGGCACATAGCCAATAATTGACAATTTCGGCAAGTCGGCAAATTGCCGGAATTCAAAATCTCCGGCAAATGGCCAAATTGTCGAAATTCAAAATTTCTCGAAAATCGTGGCTGCTAATTGCCGGAAGTGAAAGTTTTATTGATAGAGATAAATTAGAACTATCACTAGAATATGTAAAACAACTAGGAGTTATCATGTAAACTTGTCATTTGAATTTAACACTAGCAAATAGATTGGGCTTCAGATTTTGAAAAAATTAATATAACAAATCAGGAATTTTTTGAATTTATCCACATTAATCTCGATTCGGTATCAGGAGCATAAATAGGATCTTTTAAGATATATTGACAAGAATTTCCGATCAAAGTTTCAAATATTTTTTACCAATTAATGGGATAGAATGTTACATGAAACATTACAAAAAAATTATTCATCAGGTTCTCGTACAACTCCATTCCGTCTGTATTGGCCAACTGTCGAAACTCGAAGAATATCGTGAAACGGTATCTCCCGTATGAAGCAGCAGGCGGTCACCGCATTCGTACAACAAATTCAAAATTCGTGTCCAAACAGTCTGGCGCAATTCGGGTGACGACTGGACGAAAAAAACGGTGCAACGGGTGAGAAAAGGCATCAGTATGAGAATATGAATGATTTGGAAAGTGGATAATTCGTTGAATTCGGCGGCCCGGAAACTCTATGAACTCCGGGTTTTGTGCAGTTGCAATTTTTGAAGTTTGTGTTGAAAATTCAAAACTTGCACACGAACGGATTTTAAATTCGATTTTTCGCGATGGTTGAGCATTCAATAAAATTTTGAAAAAATGACAAATTTTTGAAATAATTTCCGAGAAAGAGTGTAAAGTTTCAGTAAAAAAAATTCGAAGATTAAAATTTATTTTAAAACTTAAAACATCTGACTTTAAGCGAATTTTTTGACAAAGTATTTAATTAGTCATAAATTAATTCAAAAAAATTATCTAAGATTTTTAAAAACTGTTTTATACAGTTTCAGAAAAATTTAAGAAAAAATTTTTTTTCAGAAAAAACCGGATTTTCTGTTAATTTGAAATTATGGAAAAAAAACCCCAAAGGGTATTACGGAACTACGTCAAAATTCTGAGAATGCGTACCCCGCAATATTTCTGTGGAACTACAATTCTAAATGACTTCTGTAGTGTTGGTGTCGACCTTTACGGGCTCGATTTTAGATCGAAACGTTATTGAGCAGAAAAATTATCACATAATACGAAGAAACGAAGGAAAATGAAACTAAGTTATAAAAAAATTCGAAAATCGAGATCCCGTAAATCGACGCGCTACAGTAGTCAAAAATTAACTTGAAATTAAAGGATTACTGTTTTCGCTCCGAAATATTTTGCGAGTCAAATGTCTTGCGCAATACGCAGAGACTAAATCACAAAATTCTATGCTCCCGAAATAGACTGAGAAAATTTTTCCAAGAAAATTCCGTTTACGTCGAAAAAAAAGAAAAAAAGGCGTAAATACACCAGTTTTAATATTTACTGAAAAAAATTGGTATAATCTAAAAGTTAATCAGCTGAAATTGATATGTTTTCGGATAAAAAATTTTGGCGGGAAACTCACGTTAAAAAAAAAAATTTCAGTATGCATCAGCCGACTGGAAGACGACGACGAAGCGATCCGCGCTTCATCTCTCATTTCCCTTAATCGATGTGATCTACGAATACACGAAACGGACGTCGGAGTGATCCCCTGGCCTTGCTCAAAGAACCAAATCGAAGTTCCAGTCGAGGCTGTGGATAAGTGCCACCTCACACATGTATGCCTCCAAGTGCTTCTCCATGGAAAAAACGCAAATCACGAGACACTTATCACAGATTCTGTGACATCTCATCCTACCCGTATCACGTTTTGCACACAATTTTGATGTATGACTGACGTGTGAGAAGAACGCTTCCAGAAAGGCTTCTTGAAAACGAGATACGCACGAGCTGACCAATTCGTCTTAAGGAGATTGTGATTACTATTCGATGCTCACCAAGCTTATACTCGGTACATACGGCGGCTAAATTTTTTTAGAAATTTCGAAAAAGACGAGAAATTCGATTTCTTATCAGTTTACAAAAATCTTCGCTCCTGTTTCTGACAATTTTAGTGCCGTGGAATCCATTCAACGAAAAAAATTAGGTTCTACTGGTTATTTTTGAGCATATTCAGTAATTTAAGCCATACTCTTTTACTTCTAAACTATCCGGTGACGATACGTGAACAATGTCCAAAATTATATATTATCTAACGCTACAGCATATAATTTTTACCAACCATTTTCATTCATTTTATGGAAAAAAGCATCTAGAACATATGTAATATGTTCAATTGTTCGATTTCAACAAAATTCAAACCGACGGCATGCTCCTTGGTTTGAATCGAAAGTTCAGAACAGTTTTTCATAGGAGAGCAAGAAATTGCAATGCTTGACGTGAGAGGAAACGTACGGATACAACGTGTTGAAATAAACGGAAAAAAACCGATGTACCGATGGCCACATGATTTGAAGATTTTCAAGTAAATTGTCAATTGTCGATTCACACCATTTCGCAAAAAAGGTTTGTTTTTATTTTATTAATAATTATTAATAATGAATACGTATTTGATCATACAAAAATAAAATGTCTTTTCCAGATTGGTTGACCGGGTGACTACTCGACGACTGACCTAATCACATGGAAACGATGAGGTAGAAAGATATATTCACAATTGCCGACGGAATTTCCACTCCAAAAATCAGGGCAATTGAGGGTAGCGATGGAAAATGGTATAAAACTGGAAGAAGGACGACGTACGACAGGATGTGCTTGTTGAGGATAGCAAATGTTTGATGTTACGAATAATATGTTGCCGAGAAGGCGATGCTTCGGACATATAATGTTCTTCCGTTAGACACTGAATGTGGAGTTATAGAGTTTTGCGGTTGTTAGCTTAGGTTCATTTTTTTTTCGTTTTTGCAAAAAACCAAAATACTATTACGATAACTAGGCTGAGAATGCGTTTGTACAACATATTTGACGAGCAAAATATCTCATAGCGAAGACTACAGTAATATTTTTAAATTCCGACCGTAGCGCTTGTGTCGATTTACGGGCTCGATTTTCGAATATTGCGGGGCCGTGATATCATGAGTATGCCTATTTACTGGCGCGAAAATATAGGCACGGAGCCCCGGGGAGAGAGCGTGTGGCGAAGAGAGATAAGACGCAGGTCCCTTCGCTACGAGATATTTCCCGCCAGAAAATAGCATTCTTTTTCATGATCTCATGGTCCCGTAATAAGCGATTCCATCTATTTCACTTCAAAAATCGAGATGCCGTAAATCAACACAAGCGCCAATTACTCTCATTTAAAGAATTTCTTTTAGCTACGAGATTATTTTTCCCGTCAAATATGTTGTGCAATACGCATTCTCAGAAGAAGAAAGAGGCGGGCAGATAGCTGAGTCGGTATTGGTGGCCGTTAGTGGAAGTCACGAGTTCAAGTCCGGCCTCACCCGCTAGGTTCACCCAGCCTCTATTGGGAAGTGGAGCAATCCACCACTGAATTATCGGTCCCAGTCCCAGGACGTGGCTTACATCACCCAGAGGGATCGCCACCAGGCAGTGTACCTGAATCCCAGCTCCCCAGTGCATAGCACTTGAAGAACGTCGTCAACTTTAATCCTTAATCCTTTAAAAATGTAAAAAAATTTCATTGCCAAAATATCAAATTTAACTATGAGACGTTTTTTCTATTATTTTTCAGAAGAAGTTATGTGTGGTGTGACACGAGAAGGCGGTTTCTCCACCGGGAGTTCAATTCAAAAGAAGTTTCGGCGAGTAGATAAGTGTCAATGACGAGACTAGTACAGACAGAGTCCACCAGAGACACGACCAAGTTTTTGTGGTGTCAGCAGTATTCTCCAGTTTTTAGGTAATTTTTCTGAAAGTTGTCGAAGTTTTTTGTTTTGAAATTAACATAATTCCCAAATAATTGGCCTTTTTTCATTTCCAAAAGATAAAATTACAGCCACTTCTTCTACACCAATGCGACGGCGCAGATTTGGCGGCAAAAACTTATAAATTGTGTCACAGGCAGAGCTTGGCCACGTGGCGCGAGTATTGGTAGGTCTCGAACTATGCTAATCGAAATGAATTTTCGAAGAATTCGAACATCTCAGACTTTTTCTGAAAAATACATAAAACGTTATTTTCCAATTTTATCAAAATAAGAATATATTAGTTTCTTGCGAAATGCAGTCTCAACAAATCTTTTTTTTAAAAATCAGATTTTTAAATGCTTTTTTTAAAACTTTTATCGTTAAATTGAACGTTTATGAAACATGGCGAGAAAAACTTTTTTATTCGCTTTTACAAATAATTCTCAAAATAAAAATTCCAGTGTGCTACATCGTTGGCCTCGGCGATCGACACGCGTCGAATATTCTATTCGATCAGAAATTGTTCACATTGGTGCATATCGGGATGATTTTGGAGTATAGTAAATGAACTTACCGGTGCCAGTTCAGCCCGAAGTTCCATGATTCCGTATAACTCTATGGTCGACCCGATTCTGATTGAAGGAATCGAGAATGGACAGTTGGCTGAGGAACGTACGCAGATTATGGCGATAAAATTGAAGGAAAATGGAAAGGTACGGCGGTCTGGGGAAATTTATACGAAAAGAAAATTTTGGATCGCTGACAATTAGACTTGTAAAGCAATTTAAAAATCAATTCAAATTTCCCCCCAAAAATATTTTTTCAAATAATTTGAATTTTAGCTAAATTTTTAAACAAATCTGAAATTCCCGCCAAAAGTTTTCCAAAAAAAATGTTCCCGCCTAAAATGTTTTATAAATTCAAATTCCCGCCAATTTTTTTTACACAAAATTTGAATTTCGCGTCAAAATATTTTCCAAAAAATATTCTGGGAAAAATTCCCTGAATAGTTCAATTGACGCCCCACCAAATATCATTCAGAATAAAATTTTAGAATTTCTCGCCAAACTTCTCTTTCAATTCCGTCAATCCCCTCAAAATTGCCAGGGCTTTAATCCTCGGTGTCGCCTCTGCTCTCCGCGAAACAATGACAAATTGCCAAGCCGAAACCAGCAGGCTGCCGGCCGCCCGTCCTACAATTCTGAAATGGCCATCGGGCGGCTTGGAGAAAAGCTACGGGGCACCGATGACGGTGTGACGGCCCAATCGTCGTCAAATTCGGCGACTTTTACGAGAAGCTACGAGTGCTGAGAATTTATCGCGTTCTGCGGATGGATGCCTTTTTTTTAGAGAAATAGAGAAAATTTATTCTCGAAAATTAAATTTTTACTGTATTATTGATTTCTCGTATCAATTTTTCAGAATTTGCTTTGTTTTTTACGCGCAAAATAATCTTTCTAATTTAGAAATTTTTAAAATCTAGTTTCTGAAATTTCTGCAAAATTCCAGGAAATCAAAAAATGTAGTTTTCCATCCTAATCTTTTTTTTCGTTGATTTTCCCCAGAAATTTCAAACTTTTACTGTATTAATCCCGATTTTTAGGCTCATATCATGTAATGTTTTTTGTTCACCATTTACATGTTTTTCCTACCTCTTATATGATTCCCCTTCCCCGAGGTCTCTTTCTTCACAATGTTTAAAATTGATTCACTGTTGAATCTGTTGTCTTTTTTCTATGCGAATTTTATTAGTTTTATGAAAAAAATTTGTAATATTTTTGAGTAAATTTTGAATCTTCTTACACTACCAGCGCAGTTAACCATTTCAGAGGAGTTTCTAAAATAAATAGTGAATTTTTACAAAAAGTATTATGATATTCTGATTTCAGACGTACATGAATTGCCCGTTTTCAACAAAATAAAACAACTTTTTATTTGTGCCCAATTTTTTTTCAGCCATCTAATGACTGTCCTTTTTTTTTGGGCAAAAGTAATAAATTTTCTAAAAGCGTTTAAAACTATTATATTTTGAAAAAAAACCATTTGGGTTATCAGTTGGCCTTGGCAATTTTAAGTTCTCTAGCTACAAATTGAACCAATAGAGGTTTCAAAATTGTGAGATTTTGCAAAAATTGCCACATTTTGCCACTTAATGCTTTTTGATGGGTTAAACCTAGATTTTCTGAATTATGCATATATAAATTACCCGTTTTTAACAAACGGTATTAGGCAACTTTTTATTTGTGTCGAACTTTTTTTCAATGACTGTCCTTTTTACTGTTTTGGGCAAGAAAAATAATTTATTGGAATTTTTTTCTATGTTCGAAATTTTTGAAGTTTCTTGCAGCACTCCGAAAAACCAAACGACCAGCACTACTTGCAAAGTCCGAAAAAGTTTAGAAATTTTGAAGTTAAAAACTCCCAACTCCATAAACTCACGATATAGAAATTAAACGTTTCCAAACATGTCCGAAAAGTCCAAGAAATATCAGTACAATTTCGAAATTTTTTTCATAACACTTCTGAAAATAAAAAACCGAAACTGCAAAAATTTGAAAATGTGCTAAACTCCAAACTGTACGATTTTCCACATTTCAGAAATTCCAAAATTCGTCTGCCAAATCCCTTCGGCGCAATAATCCCCCGGGGTACCCCCCCCGCCCTAGAACCTTTTGCCTCTATTGTCTCTGGCGCAGGAACTTGAAATTAAACAATGAATCGATATTTTAAACTGGTAATCGTAACCATCTGCTCCGGATGTATAATCGCCTACACGAATCTATTCAATCGATCGTTTTTCAACGGGTACTGTAGTATTAATGCTACGTGGCAACAGTCACAAGGCGAAAACGACAGTCAGTGGCAAACTCGTTGGATTTGTGTCGTGCTTAGTCAGGAGGGTGTGAAGCAGTCTATTCCGCCGTGGATTGGCGAGGTTCCCAAAACAGTTGTATCGGGTGAGAAAGATTGATTTTTAACACCCGTCTCGCCAATTTTTTTCTCAGAAATTGGAATCCCCGTCACAAAACTTTTACAGAGTGAATTTTCGAAGAAATTGGAATGACACCCAAAAATTTTCTGAAATCTAGATTCTCGGCAAAAGTTTTCAGAAAGTTTGAATTCTTGTCAACAATTTTCTCAGAAATTTGAATTCCCGCCAAAATTTAAATGCCAGAAATTCGAGTTACCACCCTTCTCTTCAAGTCTAACAGTATTCAACAATATACAATTAAATAGCTTTTCAAATTCCTAAAAAGTTTGCTGGAGTGATCAATTTTTTAGTTCAAAACTCGCTAAACCACTTGCCCATGTAGACTACATAATCAATTCTGAATAGAACGCTATTTTATCCTATTTTCAGACATCAAAACCGAATAGCCTAATCGCGTGGGTCATTGAAAAATCATTTTCGATCTTTCTGCTATTATGTGGTTTTGACACGATCCAGGCCGTTGATATTGCGCCAACGAACACTGGCTGATATTTTTGGAGACAGGTTTGCGGCAAACGAACTCCGCTGTCGACTCTCGAATTATCAATTTGTGCATAGCTTTGTAAGGATAAAAACCAATTTACCGAGTTGAAGAAGATCGGAAGCTGGCAGTAAATGGCTCGATTTTCACTGTGGTTCGGAATCCGATCGATGGGTTTTGGCGTAACTCAGGCTTCACGGATAAATGTTTAAGAGAAAATGTCTGGAAGTTCAAAAATCGCGCCGGATGTAAGACTGTGCGTTTAATTTGCAATAAAATCTTTTAAACAATTTTTTTGGAATCTTTTATTTTCGGGAGTTTCGAAAGTATATTGGAGTTTTTTAGGGACCAAAACAATTTCAATTGAAAAAGGTTTTTTGAAAGGGGGTAACATTTTTCTAGGCCACTAGGTGCCCTTTGTAAGGTGGCCTAGAAAATAATGTAAAAATCTAGGCCATAAGGGTTGCATATTGCCTGATGGCCTATGAATAAGCTAGGTGCGCCATAACTTTTATCAGGGTTTAGGAACGTTAAAACTTCGGGCAGCAAGATTCGCATAATGACCTAAAACTTTCAATGGAGAACTCGGCTATAAAAATCTTCATGATGGTTTCAAAAAGCGGAACACTCGGGGACCATAATCTTCTAGAATTTTTAGTAAAACTAGGCCATTAAGGTTTCTTCCGTGGTCTAGAAATCGATTCCGGGCCAATACTAGGCTGCCAGGGTTTCTAGGCCACATAAGAAAGGCCTAGGTACAAAAATTATCTCAGAACGGTCTAGAAAAGTGGATAACTAGGCCACCAATTTTCACTTCGTCAGGAGTTTCAAAAATATATGATTTCATGATTTACTTTTCGTAGTTAAGAGTCTTTTTTTTCAAAAATTCTAAGCAAACTTTGACACTAAAATGCTTGAATTTTTGAGAACTTTGAAAAGTGTTTAAAAATAATTTTTTGAAAATTTCTCAATTTTTTTTCTTCGAAAAGCTCAAAAAAACGATAAATTTCCACATTTTGGCCAGAATTTAACATTTCGTCGATAAAATGTACGATCGGAGGCATAGATTCGCGCGGAATCCGTACAAAGGAATCGTTTTCGACGACAGTCACTTTTTCCCACAATCTTGGTATCGGTAAACGCGCTCGGCATTATAGATAAAGTTGGAGCGCATTTGCATTTTGAATTTTGATGTCTGATATTTCTCGTTATCCGTCAGGCGATGCGAGTTCTCGTACTCTCATCTTGGAGTCAAATACCAAATTTTCCAATTAGCCGGTGCAAATTTCACAAATCGTGTGAACTTCTTGGACTGCTGTCCGAGCGGGGAGTTGATGAAATGGAATTAACTTTATTGTGAGTCTTAATCAAGTTTGGGTCTCATAATACCGCGAAAACCGTAATTGATTGGGACAATGGGACCCAAGAGAGCACCCCAATGGAGCGGAATTGCAACTCCTATTTTTCCAGTCGGAAGTCTCTGCCATCACCGGACCCCACACAGCACAAAGGATTCCGTGGAACGGGCGGCCGTCCAGGAAACTGCTGAGTAGTCCCCAGTATTTGTTGCGAAAATTCAAATGTATAATTTTGACTTTTTGCAAGATATTCGGGTATAAGCTTCCTGATATTGCAGTTGGAAATTAGTAAAAGCGTTAGTATTTAAATGTTGTTAAATAGTAATAATCGATAAACTTCTTGAATTTTGATAAACTACGGCCACGTCAATTTTTAGATATTTAACTGTCCGGGCAAAAAAAACCTAAAATTCCCGCGTTACAAATTGAAAACAAAAATTTCACAAAACGAATAAAAACGTCTAAATGTTTATAGCTTAGGCTGAGGTGAGATTTAGGCTTGGGCAGGTTAGTTTTTAATTTTCAAGGTTTGTCATTACGTACTTTATTTCCGAAATACACAACAGAAGTCTCACAACGAGTCAGGGGTCAGTGCGTGTTGGTGGGTGGGGTGGGAGATTCTGGTGGGGACCACCACTCACAAACAAAGATCACAACAGGGAAAATGTACACGTGGCAATATGGTGAAGCTATATGTATATATAATGAATAATGATATGAAAATTTGCATAATAGCAGGAACAGTACCTGATTGTTCCCTGGGGCGAGTAGAAGATATGTGGGTTATCTATCGATTACCATTACACATGAATTACGCTGTTACGGTTAGAATTTTGTGAAAAAAGATGAGTAAAACGCTGGGACGGGGCTATAAATCATATCTATAATTGTCGAAGATGCTCCACGAGCCAGGAACGAGGGGAACATTGCGTCAAGGGCGGTCATTCCATTGTAGTGATGATGGTGCAGCTCGTGCATTGATTGCTGTAGCAGTAGGGACTCCCCTCATCACCGAATTGATAATCTTCTTTCCAGATGAGAAACGCTCAAGACGGGAGGCGTGTTGGAGCACACGCTGCTTCATTTAATTCTCGTACCATCCAGAGTAATAAGAGAAGCAGAATAGCTGGTTGAACTTGACGTCCTCTGGAAAAAAACAATATTTTCTCTAGTTGCCCACTTAACACTTGGACAGAATTAGAAATATTTAAATCAGGGCGGGCGGCAATTTAAGGTTTTTACACTGGGGCAAATTCAGCAATTTGCCTATTGCCGGAAGTTTTTAAAACAGGCTCTTTAAAAGACGGATACACTTAAAACTGTGCCTTTTTGAAATTTTCTCCCGATTTTTTTACATTTTTTCATAGATTGTACTGACTTTTCACAATAAATGTAGGCATTTATAGGATGCATACAATTTTGCCGATAAAAATTGAAACTGTGAAATTTTCAGAAAAAATGTGCCCACAATTTGCCGAAAATTTTAGTTCCGACAATTTGCCGTTTGCCGGTAAAGTTGAAACCGGTTCCCAGGCCACGTACGGATCAGTTTTTGAAGAAAAAAATACGGCAAATTTACAGAATTAGTACCATGTGGATTTCTTAAGAACTATTGCCAAAGTACGTAGAATGCAGAAAGTTTCTTGCCTTAGTGAAATTTTGGAATTTTTCGGGATTTTCGGAAAAAAAAATTTTTCCATGAAGACGAATTTCTTTTTCAAAATTTTTTCACGAGTGTAACTCTAATAATACGCCTCAGACGCGAAACGTTTTCCGATCAAAACACGGCCGGGGTCTCGAATCGACATGCAGTATTTTTCTCGCTTTGTCATAGTTTACTTCTCGACAAAAATGGATTTTTTTGAATTACAAAATCCTTAAGTTTATCTACCCAGAGGGAGAAAAAGAAGACCTCCCTATAAAAATTTGAAGAGTACTCATTAAAGGCGCCCTTTTTTCGAACTTAACCAAAAATTGTCGTGTCGAGGCCTGGTACCGTATTGTGGTGCGAAAATCATCTAATTGCGGCATTCGATTTTTGCGTTTTTTGTTATTTTAAAAAAATGTTCAATTTTTCAAAAATAGCTTTTAGATAAAAATAATAGGTTATTCCTTCTTTTATTTTACGGTCTTCTAAATAATTTTAACATTTGGCACTTACGTTTCATCACAGAACAGAAACTAAAGACTCTGTGCCAATCAAAGGGGCGGTGCAAATCGAAATCATTTGGTGAACAACATAGTTGCCATACTGGTGGAACAGAAGATTATCCCAAACGCATCACGATACGACTCGACATCAATCTTCACAAATCCACACTATGAAAATCTCCTCCATCATCTCGTGAAGCAACGGTCGGGCGGTGCAAACAAGTACGCTCCCTCGATGACGTGCGACGCATACTTGGTGACAATGATAGCTAGTTACGGAGCAGGCATATATCGATGATAGTGTCTCTGTACATTTCCATGATACGTTCACCGACGATTTGATGATCCATATTGGAAGACGTAGTTGGCGAACTCGTTGGAAGACAGCCGGTAGCAATTACGGACGATACACGTCATCAGAGAATGCAACAATTGAAGATGGAATTTGAAACACGGGAGCTTGGGATTCTCGGGGGGTCTCTCGATGACCTGTTGCACGAGAAGACATCCATACTTGTCATCGGGACTGGCACACGGCCATCGGTGAATCTCCTGAGGAGAGGAAATGCGCGAAAAAGGTCCACATGTCGACTGGACGGTTTTCGAAGTTTGACGACACGTTGAATCACGTGGATCGAGATTTGATCATCATCCACAAGAGATCAGCACATTGCCGCCAGGCGAATGTGCTTAGCTCTTGGATGAGCTGGAAGACGTTGGCATGGTCGAATTTCTGTTACAAATTATTGATTTGTTACACCTCGAAAGGCCTAAAGACACCAAACATAGCCCTAAAAATTTCGAAGCAATGGATTAATTTTAGCTAAAACGTAATTTTTTGCCAACCTTTCTGTGTCTTTTTTAAACCAAAATCGAACAATTTCGTTGTACGATATTTTGAACACATTTCAATTTTTTCGGGGATAATCGTATATTTCTTTTCCTCTAGGAGCCTTTTATGTGTATGTTTTTTTCATCGACAAAAAATTTTCGTTAATGTGTGGACCTTTAGGTAGTACTGTAACTTCATTAAACTTTCATTGCTGCGGAATTTTTTAAAATTGATTTTCAATGTTTTTCTACAGTTGTCGTCCAATTTCATCAAAGAAAAAAACAGAAGGAAAAAACATCGATGTGAATTTAAAAAAATTGCGGATCAGTGAAAAGTTCGGAGTTTAACAGTACTCTTTGAAGGCGCCTGTAACACCTTTTTTGTTTTAAATTTGTCGTGATGAGACTCGGGACAGTTTTTCGTTGCGAAAATCGCTGCTTCGGCTCATATCGAAGAAAAATCAATTTCCGACCGCTGCGACACCTTAGCAAAGGAAATTGTGATTTTAGCCAAAAATCAATTCAGTTATATATCGGAATTCCCTGGCGAGACGTATTTCTCCCACAGCAACTGCACAACGACATGCGAATTTATCCTTGCACATGGCAAAGGCAAAAGCCCACCGTCGATCATTTGACAATCCCCGCTGCTCGGCCGGTGTTGCGAGCTCGACGAGCTCAGCTCTGAACCATGAAACGATATTGCACTTCGACTGTGGCAGAGCCCCACGAAGAGCGTCGTGGATTCGCTGAGCTTCTCGAAGCCGGCTGTACGAATCTGATCGTGGGAATCCAGTGGGTAGTTGGCTCCAAGAACTTCACGCCCGATGGATCGATTGCGAAATCGATGATCTGCCCGTTGCAGCACATCTTCGAGCGAAAAGAAAATCGGAGCAACTGGTGGTGGGGTCTCATCGTCGGAGGAACCCGATCCACTGGTAAAGATGTTGCTGTCGAATCGGAGAGTGTTGCTTCCGTGGCGGTAGGGAAGAAACTTGACCGACGGCTTCGGATAAATTCGAATTTTAAATTTTTATTATTTTCTATTTAAATTCGAATTCCGTTTTATGCGTTCGAATATTCCGCGTTGTTCTTGTGAGTTTTGTTCGACAAAGCGAGAAATCCGGGTCGAAATCGAACGACGCGCCGAGCATGTTGGGCTGTGCTTCTACGAGTCGGGGTCATTTAGACGGAAATGAATGAATACAGGTTAGTAGACGCTGAAAAAATTTGGGAATTAGGATTTTCAACGGAAAACAGAGTGAAAATGAGAGGAAAAAATGTAATGATTTTTTTTCAACGAAAATCGCGAAATTACATCAAAATTCAACATTGAGGCCATTTTTCGCGGTGGCCCAGGTTACGGTGATTTTTAAGCATGGTTGTTTTGAGTAAGGTCTTGACCCGTTTAAAATTATTGAACATTTCATCATTTTATTTTTAGTCATTTTTAGAGAACAAAATGATTAAAATTCGATTTCTTAAAATACATTTTCACAAAAATTGCAAGAAATCGCTGGCCAAAATTCGAAAATGAAGAGTTAGGCGGTGCTCATGGATTACGGATTTAAAGGCACATGGCTTTTTTTTTCACCACGAAAGGAGGATAGTTTGCTTCCCATTTTGGGGCCGATTTCTTTTTTTAATTTGGCTTTCGCTCGATTTCCACACATTTTCACTCATTTGCACTCAATTTTTTTGCAGAAAAATGTCAATGGATATGTTATGAAGTCAGATGAGCCGGCGTTCATCTCTGCGCCGGTGCAATATGACTTTAAGTAAGCTCAAATGTTTGTTATTCTGGCCTAAAATTATTTTTATGATTTTCAGAACGTTCGCATTTTTCGCCAAAGATCCGAAGAGGAATGCAAACTTATCTTCGGGCTCGAACGCTCGAGAAAGTTTCCAGCAGGCCACGGGGCGCTCGGAGAAGATCACGGAAGACATTTCCGCCAAATTGAGTAGGTTTTTCGATTTTTTTACCCTTAAACTACTATTATTTTCCAGCGTCTCCCACATTTCGTCGACGGCCTTCAAGAGAGATGGTCGGTGGCATCGAGAGAAATCGGCTCGGCTCGCAAGCGATTCTGCTCGACGAGGACTCCAGGCGCCGCAGTCCCAGCATTCTTCAAATCGATCACGCTCCGCTCTCCGCTATGATTCGAGAGAGTTGGCAAGGAGATCGCCTCATCTGATGCCTCCGACTTTTATCGTAAATTATGGGATGATGAGCTCGAAGAGGTGAAGGAAGAAGTGGTTGCCGTTGGAGAAGCCGTCTTGCCCACGCCAAAAGTCGAACTGAACTATGGACCCAGCATCCGGAAAAGGACCTGATCGTCAGCATTTCCGTGTATCTCGGCTACACCCGTACCCTTCAAATACCACGTGATTCGCGGACGTTTGATGAAGATCACGGATCCCGGCTCGAGCTCACATCAGAGACACGCTTCGCTGAAATACGCGTTCCCCCATTCTCGTTTTCCGACGATTATAGCGAGAAAAAGCCGTCGAAGAATTCAAGGATATGGCGAAAAATCAATGGCAGTCGACGATGTTCTTCATTCAGGACAGGTTTCATAATATAACTGGAAATAATTTAATATTTTTCGAACAAATTTGATATTAACCCATCTTATTTTGATAAAACTCCGCCGCTGCTCTCTGAAGCAATGAACTGCAATCCGACATCAGCGAAGGGATCAGCCGAACTGAGACGGAACCACTGCCATTGAGCTTCTAGCGAAGGAGAATTAATTTATTTGAATTTATTGTACGCAATCGTTCCCATATCTGTGAGCTAGCAAGCTAGCTAATCGTGATTAATTGTTGGGTATTCCTTCTCGTTCTTCAGCTTCTCCACAAGCATCTTGTCTGCTCATAATCACACAAATGATGTCATCAGCATCGCTCTGATCTTGAAAATCCTGAAATTATAACATTCTAGAGGGTTTCTGTTGAGTATAGTTACCTTACAACCAACACCAAATATGTTCTTCATTATGGCATCCGGCAGCTTTCCATGAATCGCAGAAGAAGTGCTCGGCATCAGATCGGATGCTCTACTTGGGAAATATCGACCGATGCGGCTAGACACGAACCATGTTGAGTGGCCGAGAGAGGGATCATCTCAAAGATCTAAATGTAAACTAAACAAGAGTTTAGAAAATTTAAAACAACCTCCCTGATAACGTAGTTAGCTTCTCGCGGAGTGAGCTTCTGCTTCAAAATGAAACAGAATGAAACAAGAATCAACTGTGTATTGTACAAAGTGAAGTATTTCAGACATTTTCGCTAATTTTGGCAGTAAAGACCTATAATTTTGGTAAAAATCGCTTGTATTCTGAAAAAAGAACTCAATATTTAATTTTTTATTTTTAACTGATTTTAAAGAGAAACAAACGAAATATATGAAATCGAAGAAATCCCTGAGAAAAAAAAGGTGCTCCTCCGCAATATTTGTGATTGTTAAAGGGACAACGACTGTTCATCGAATGGGTCCCTCCACGATTGTCCATGTCGAGCGCTTTTAATCGCGATATTTTACTACTGTAAAAAAGTGTACTAGGAAAAACCTGTGTAATGTCGAAAACGTCACAAATGTATTTAAATACATGTTTTTATTGCTTGAATAAGCCGGCAAAGTATGTATTTAAATACACTTTAATTTTCCGACATTATTTGAATAACCCCAAACCCCGAAATTTATTTTTTGTGAAAGTGATAACCAGAAAAATACATGTTAAAACAATTTTGTGAACAAAAAACTAAAAAATATTTTTTTTGCAGAGATGAATCCCACGTGAACGGTCGAATTTCCACGCAGCCTCGTCGAACGGACTTTCAGAAGAATCGCATGTGACACGTAGGAGGCGCCATGTCGGCTCAGTGAGTACAAAAAAATCCATGGGGATTTTATAGAAAGTCGGAATTGATTCAATAAAATCGATTTTTATAATAAAAAAAAGGATTGATTATTGGTTTTTGAAAAATTTAAAAATTACAAAAAATCTATAAAATCGATTTTTTAAAAATTGAAATTCAATAGATTTCTAACTTTAGAAAAATCGAAAAATAATGTTTTAAAAATCACCCAGTCAGAATCGATCAAAAATTCAATTGTCATCGATTTTATTTATTTTCAAAAAAACTTAATTTTTATGAACATCGATCATATCGGATTCCAAAAAAGAATTGGGAAAAAAGTAAATTTTCAAGAATCGAAAAATTTTAATTTTGTACAAATAGTTATTAATAACTCATTTTTTAGGTTTTTTTTCAAAAATTTGAACTAAAAACACTTATTTCTCGAGCTTTTTTCACAAATTGACCCTATTTAAATTAAAAATTCACAAGCCAAAAACCTTCTATTTTAACCAAAAAAAAAACGAAATTCCTCTCCCAAAAATCATCAATTAAATCCTTTTCAGCTGGATGATCGTAGACCACGACAATCGGCTTCCCAACTCGCCAGGCTATCTGTGCTCTTCGTGCTACAAGGTTAATTTCCTCTGTTTCGACGTGAACGGCAACAAAGTGTGCCATAAGGCCGTACCGTATTGTGATCGAAGGGAAATTGGCCACGGACGCCAAGTCTTTATCCAGCTCGATCTTTAGAGAGCGAAATTTAAAGTATCATTTTTTCTTGTTTTTTTTTATGTTTTTCGATTTGATTGTTTAATTACCAATTTTTGGCCTGTAACTGTGTATTGGTTGTGCAAATTTCGTTTTTTGAAGGTTTTAAATTTCTGTTTGGGGCAAAAAAATTTATCCAATAAATAAACGGAATATATCGATGATATGGCACGTAGGGGGAAACGGACGGGCAAGACTATTTACAGCAAGGGCGCGCACCAGAGGTTTCTCGACCCCCGAGGCGGGTGGCGGAGCCTCAAATCTGTCGGAAAAATGTGAAATGAGAGAAGAAGTAACCTCTAGAAAAGGAGATGAGAAATCGGAAGTTCTGGGAAAAAAAAATCAACTTTTGAACAATTCACATTGACGATAATATTGATTTTTTTAAAATTCTCTAAGATCGAGAAATCTGGTTTGGAAAAATCAATAAAATGAATCTTAAATATCTTTTTAATAAACTATTTTCAAAAATCAATAATATCGATTTTTGAACAATTTGAAAAATCGATAATGTTTATTTGTAAATTTAAATTTTATTGATTTTTTGATTACAAAATCGATTGTTGATTATTGATTTAAAAATCACCAGAATCGATAAATCTGTTTCGGAAAAACCATTAAAATTGATTTTTACAAAAATCAGCCAATAAAATAGATTTTTTATAATCAAAAAAATCTATGTGCTTTTTAAAACCGAAAAAATCGATATTTCAAAAATTGAAAAAAATCGATCAATAACTAAACAGTCAATACATAGGTGAGCACGTCTCATCTATTTGTGTTTTTGCGATTGGTCTCGACAGTTTTGAGACCGCTAGGCGTTGTTCCGCATTCTGGAATTTTTTTGTGTTGGGAATTTGGCACGCCCACCAAATGGACGGTGGCGGAAATTCAATTATTTTAAATACCTTTCTGGATAAAGTGCAAAAATGGATTTTTCCACTTTGTCCCTTCGAGTGATTCGGAAATTAAATAAAACATTCAAATTATTTAGGGGCAACGAAAAAACTCTCAATGCACCCACTGTTATTCGGAGTGTCGTCGCGGTGTGTTGCTATGGATCGTGTCCATGCCCAGCTTCATCGTCGACTGACGTAGCCGTTTTCTGGTGATCTGAGCGAGATTTATTTAATTGATTTTTAGGAAAGGCGCATGGCCTAAAAAACACAACACTTCGGCCAGGGACTTTGGCGGCCGAGCTAGGCCATGCTGCGGCATTTAAAAGCACATACCCTACCATGATAAACTACTGAAAATCGCCAATCCGAAAATGATGACCAATGCGAAACTGATAACTGCTTACAATCATCGATGAAGGAATAAGATGAAGTTTGCGTGGAAATGGAATCGATGTACGCTTGTGAGGTCATTCCTGGAAGTTATTGATTTATTTTTCGAAAAAAATAATTCCTTAACGCAATAGTCACACTCAGAGTCAGCGAATTTTGTTATCCGAAATCATAGAGGTATTGCGTGAAAATGCGGCTTCCAACCTGAATGTTAAAAAAAAAATCTATAATATCGATTTTTTGAAAGTTTTTGGCGAAAAATTGATAAAGTTCGATTGATTGTTTGCCCATAGAAACAGATAAAACTCTATATAACTTAATATCGATCTTTCGTTTTTTTGCGCACCTTTAAAGAGTACTGTAACTTCAAACTTTCATTGCTGCGAAATTTTTTTATCGGTTTTTACAATTTTTTGTACAGTTTCCGTCCAATTTTACAGAATTGAACAACAAGAAAAGTGAAAAATCGTAAAAAATGTCCGCAGCAATGAAAGTTTGGAGTTACTGTACTCTAGGCTTTAATGGCGCACACCTTTTTTGCTTCAACAAAAATTTGTCGTGGTAAGACTGGGGACTTTTCGGCGTAGAAGTCGCACAATTTCGGTATGGAAGAAAAATCATTTTCCAACAGCAGCGATACATAAAAATTAGCAAAAAATTGTGATTTTAGCCTAAATTTAGTTATTTTTCGGAATTCCCGTGGCCAGACTCATTTCTCGCACCTGTGATAGAGCCAACTGCACACCTCGACATGCAAGCATTTTATCCTTGCAGATGGCCAAAAGCCCTCCGTCGATCATGACGAAGCAATGCCCGCTGCTCGGCTGTTGCCAGCTCGACGAGCTTCTGAATTAAGATTTGCGATTTCGATTGTGGCACCCCACGAAGAACGTCGTGGAGTCGGGGCGCGAAGACGGCTTTACGAATCTGATCTTCGGAATCAAGTGGGTAGTTGGCCTCCAAGTACTTTACGCCCGATGGACCGATTGCGAAATCGAGCTGCCCGATGAGCAGCACATTTGAAGCGAGATGGTGATCGGAGCCACTGGTGGTGCAGTCTCATCGTCGGAAGATCCAGATCCGAAGGCTGTCAGAGTCGGAGGATAGTGTTGCTCCCGTGCGGCGGTAGGTAAGAAGCTTGACGGGCGGCTTTGGTTTCTGGAAATTCTATATTTGAATTTGAAAAGCAAGAAAATTCAATATTTTACCCTCGCGTCTTGTGGGTTCTGTTTGACATAAGCGACAAATCCGGGTCGAGCTTAATTACCGCATGAAACGCCGAACATGCGCGCCAACAGAAATGAATGAATACAGGTTAGTAGACGCTGAAAAAGTGGGCAATTAATTCAGGATTTTTTAACGGAAAAATAAGTGAAAGGAGAGGCAAACACATCTGCAAATTAAAATCTCCCGAAATTACCGCGCTTTAAAGGGACTCCACCGATCGGACAGACGAGGGAAGTGGAGAGACGCAAATCGAAGAGACGCCTTTCAGATCATTTTTTCGTGATAAGTTTGCATGAATTGGCAAGGAGAGCTTACACGTTAGGCGAATCATTGATAAAAACATCCAATTGTTGTTTGTAGTGTACTGAAATTCCGGAACAATAGCTCTCGTAGACCCGAAAGTCGCTCGTGGCAGGAAAGTGGAATTTGGATAATTTTGTTCTTTTTTTTAAATATGACGTTTTTGAAGGCTTGAATTTGTCTCATAATTCATCAAATTCATAAACGGAATTATCCAAATTCCACTTCACGGAGTGACTTTTGTGTCGAGTCACGAGAGCTATTGTGCTGGAATTTCAGTACATATGTAGCAACAGAAAATGTTGTTTTTACCAACGATTCCCATCATGTGTAAGCTCTGCTTCGGTTGCCACTTCATGCAAACTTATCACGAAAAATGTCTGAAAAGGCCTCTCCGATTCGCGCGCGTGTCAGGCCTCCACTTCCCTCGTCTCTCCGATCGGTGGAGTCTCTTTTGAGATTCGACCCAAATAAAAAGTGCAGGGCGCCCGGGTTACGGGAACTTTAAAAGCGCATCACGGTTTTGAGTGCAGGTCTCGACGCAAGATTAGCCGGCTACTTTTTGAAGATTTGTCGTTTATTTTGGCATTTTTGAAGGAAACATAAGTGAAAAACAATTTTAATCTTAATTGAGAGAAACTTGAAACTAACATTGTTACACATAAAAAATTGGCCAAGAAATTGCGCCACGTTTTCAAATAGAAGTATCGCGGCGGTCAAGCCGTTGATTACAGCCGTTATACACTCATATAACTATGCGATAATGTAACTCGATGATTTGTTGATGTGATCTTTAAAAAGGTTGAAACTGCCCCTTATGTGCCGGAGGCGCTGTGAGCGGCTGGTTACTTGTATATAAAAAATGTCGGGAAAAACGCACTTCCGTTCCATTTGTTTCTTTGTTGACGTCACTGAGAATTATGGGGGTGCGGGCCCGTCTTCGTGGTAAGACCCATCTTGGCGAGACATAGCGTGGTGATATCCTTCGTGGCGAGACCCATCGTGGTGAGACCCATCGTGGCGATGACCCATCGTGGTGAGACCCATCGTGGTAAGACCTACATCGTGCCGAGACCTTTCGAAAATTTGGTGGGAATTCAAATTTTCTTAGAAACATTTTTGGTGGGAAGTCAAAACGCCTTTTCAAAGAAAAATGGCTGGCGGGAATTCAATTTTTCAATAAATCATTTCGGCGGGAATTCAAAATTTCTAAGCATAATTTTGACAGGAAATTCAAATTAGTTGAGAAACTCGAGTAAATGGAGTTCTAGAACCTTCCTGGAGATTGGGGAAAATTTTGGTATGTTCTAGAACCATCGGCGAACTTAATTCTGGAAAGTTCTAAAACCTTCTAGAAAATTCGTGACAAATTCTGGATTGTTCTTGAAATTTTTAGAAGAATTCGAGAAAACGCTGGAACGTTCTATAGAGCCTTCTAGAAAATTCGGGAAAATTCTGGAATGTTAAAATCTTCAATGTTTGCGCAAACGCTCTCGGAAAGAACCGGAATGGATTCTGTTGTATGTTTGAAGAACGTCTAGAAACGTTCAAGAACTAATTTAGAAGTAGTTCCGAAACCTGGTATTCTTAAGTTGTAACTCTTGGTGACAACTTAGTTATATAATATTCATGTTGCGTTAAAAGCTTCTGGAGCAAACTGAGAACAACGTTCCAAGGCTTAGTAATTTTAGAATTTCATGTTAAGTTCGATTACCAGTCGGAGCACGCGCATTGTTCGGAACGGCTGGTATACAAACAATAGTCAGTCAATCCCATGGATCAAATCTTGAATTTTATGGGTCTAAAACTGAACTGTTCAACTTTGATATGCAAAATTTTATAAAATTATTATTGAAAGACATGAAACAAACTTGAATTACGCGAAGTAATGCTGTGAACTGAACTTACTATTAGATTCCTTTTTAGCGAGCACACTTGAAAACGAATGAAATAAGGTATGTGAGAATACCGTATCAATCAGATACGTCTGACACTTCCCCAGAAAAAACTATCAGAATATGAGTACATGTTAATGCTAGTGTGAATCTTTCCGCGACGACCATCATGGCTCAGCAGGTAAGACTTCGGCGACGCCTCGAGACGACGAGGTAGTTGACGACTTTTCTCAGTTTTTTAGGCAGCGCCCAACTCGTTGTCCGAGGTCTACAGTAGCTACATGTTTCGGACGGACAGAGTATTTGCTTTATTAGTAGTAACAGAAATACACATAAAATCAATTAATAAGACATGAAATGCAATACTGAACCAAATCCAGTTTTCACCCACTATGTCTCTCATTGAAGAACGTTTTAAATAGCTTTTGGTATAGAATATATTAAAATTCATTCTTCGATTTTCTGTGGAATTTCCTATTTGAATTTTTCCATTCCAGACAGTCACTTCTCCAAATCCGTGCATCCTTGAAATTTTCTTTGGGGATATTTTAAATATCATCGAGATACCAACAGTCTACAGACTGGTTTTTCACTTACAAGACGTGCTCTTGACTTGAATGTCTGGGATACCCTCTATGTTTTTCTCCTTTGTCATGCTGATAGTATAAGTTGAATGTGACACTTCGATTTCTTCTGGCTGTTTTGTTCAGTCGATCGGATTAGTTGGAAGCCTGTGACTCGGTCCATATTGTTTCTACCAGAGTAATGAGCGTGGACTAGGAAGTAGAACGGTCATACTCTTGGCTGGGAAGTTTCGTTGAACATATGGAGACAATCACATTGTCCATTGGTGAATAATAGTCGTTTGCCAGTTGTTCGTTCATTTCGAGTAACATATCCTCAGAGTATTGTAAATCAATCTCCACTTTTCCCAGAAGAACCCTCGAAACGGGTTGGGTGTTGAATGGTACATTGAAAACGGCATTTGAAACACTAGTCTATAGACGGTTCCAAAATTAGGAATCCAGATTTGAACTAAACATAGTATTAACATTACCACTGTTTCGATCCGGAACTCCATTCTGAATTCTTTAACCTACCACTTTGAAATAAGCATCACTGGTATAAATCTCGGATTGAAAGGAACTCTATTCCCTGTATTAAAACGGTCAATCTGTGGCATGTTACCAATTAATTGGGGCAATAATTTGCTCGAGCACCAACTACGTACCTCCCTAGTTGCTTTTCGTATATGGTCCGATAAAACAACCTGTAAAATGTTGTTAATCTTTATAATGTTCCTGAACATATCATGTCAAGAGTGTCTTCTGGAGTTTTTCATCAACAAAGACAAAATTTGATTTTTTAATTATCTAAACAATCCGATTTTTGGTTTTCCGAGGAGGAAAATTGAAACATGGAAATCCGTTTTTCTCCATTATTCGATTCTCCGATTTCCTCTCGAACGAAAAAAACGAGAATAAAGTTTCCATGACATCTCAGTGGGCTGTGGTTTTGGGATAACTTTAAGTGAAGGAATGGAGAGACTATCTAAGTATGAAAAACACGAGAATTTACTCCCTTTTGATAACCTGTTACAATACGTGGACTGTTATACTAGAAGAACTAAAGCAGTGATTCAAACATCCTGTTCAACGGTGTTCATTACAATGTATCAATTTACACCCTCACCAGTCTTTCATTTCCAGCGCTTTGTAATGTTAGTACGTGGAGATTTCCTCATTTGATTTATGATTTCTATTATTCTTAATTCTCCAAATAGCTCTTCTCCCAATAGTCGCAACTCATCAATTCCAAAATTTATGCTCAATCGAAGTGACATATGCGAATTTCCCGAATAGGTCGTTTAATCTGTCCATAAATCCATGCTCATCAACTCCAAAAATTCAATATGTCATATTCAAAACTGCTGCGTTATCGAATTTCCACATAATGAAGTTGAGTACTATGAACTATACAGTTTTTATTTCTATGAATGTCTCGACATATTTGACGACGACAGCAAACTAAAATCATTTTTTATATTCTTCAACGAGTCCATCTATGAAAACATGAATGTCATGTTAATCAGTTGTTCAAAAGCCATATATTTTACTCAGGATTCTGAACAGGCGCTCATGTCAAAAATTGACTTACAATCTACTCCAATCAAGCAATCGGGTAGGAGATCATTGAGTATAATTCGAGCATCCACTCCGCACGAAATTTCGTTTTTCTTAATCGGTGCGACATACGTAATCTTGTAGTCTTTCAATTTACCGCATTTTTTAAAAGTCTGAAAAAAATGTTACAGCTGAGTACAAAACATTAAAAATTGGGTTATTGATTGAAATTTTCACCACTTCTCATATTGTCGACCACTGAACAAACAAGCATAAAAAGCTTCAACAGACTCATAAAACACTTTTAAAGGCAAGTGTTGAACCACCTATTTTGATAAAATTGTCTGAAACACATCACAGATCGACTTTTCCGTAGCTCAAAGTGATCCTCTGCCCCTAGCTCTTGAGTGGTCATTCGAAAGTCGGGGTTTAAGTTGAAATATTTCCCTAAGCGGTCAAAATTCCATCATCAGGCGATCAAAATAAAATTGAATTTATTGGTGCTACAGTTAACACATGAAGCGGCGAGCAAAAAAACCAGGTTTTGAACAATTGAATTCAACTTACTCGAATCTAAGTGTTTCACCTGTTTGTTATCCACATTCAGTGGACATTCAGGTATAAGAAACGCAAGTGCATCGACGAAGCTGTTGCGTAAGTTCAGGATCAACTTGATTGTTAATGACTATTGATCTTTTCTTCAATTTTTAAAAGTGTTGAAACTGAATTTGTACGATGCTTCGAAAATGTTGTAGTGCAAAATCGCTGAACAATGTATTTAATAGATCAGCTGAAAAAAGAGCGAATTAGAGCAATATTGAACACAATTTTGATACCTGTCTGTAATTAGGAAAATCAGTCCGCTGTATTGATTGTTTGAAAAACTGAGTTTTTGTTAATTTATTTGCAGTGGCAAATTTTTATTATCATTTTTTTTGATAAAAGTTCATCACCAATGCCATCAGTGTTGTGGCACCACGGAGTGTGGACGCGGAAGACCGAACCCTTTAAGTCTCAAGAGGAGCCGAGCAACGAAGACTATGTCAGAGGTGGCATAGCACCAATGGCATCGTCTATTTGTATATGTATTGGGAAGAACAGACATTAAATTTATTACTCCCAAAGGGGAGATAATCAACAGAGGGGGGGTCGTACACAAGAGTGAGGGAATTGTCAGGGAATATGCACGTCCTGCCACGCGGGTCTTTAGACTAGTCTGCCAGGAAAAGGTCGAGTTAGGTATGAATAGTCGGGGTCTTTGCAGCCTCGTAGAATAATATCTTAGGACAACTACACTTTCCTAAAGGGAGGGAAAGGTAGGAAACGTCGGCAATTAGTCTGACTGGGAGGTCAATAACGGGGGGGGGGTCGGGGGAAGAGACCAAGGCAAAACCGAACCAAGAGTGGGGAAAGGAGAGATCCTTTTTTCCTGGTGCCACCGACGCTGCAGCTCGCTCCGTATCCCCCCGTCGCTCATTGAGTCGCCGCGCAGCCAATCGTTGCTACGGGGTGCGAGTGTAACTCTCTTTAGAGAGCGTGTCGGATCAGACGCAGACATACAGGTAAAACTTCTGCGACTCCTAACTGTATGGTAAGCTTAAGAGCTGGTATTAAAAGGTCGAATTGAATGTACCCGTCGCTCGGAGAACATCCTGCTGAATCTAAGTCGAGAGCGAGACTGCATTGTGAAATGGGCGATACAGCAGAGCCCAGTTCACAACTCTCCCGGGGGGCGGGACTTGTAGGCTGGTTCACGTAGTGAACCCGCTTAAGGTTCGTTGAAGCCTTCCTTTGCCGTTCTTGGAATGGCGGAGTGGAAGGTCGTACGTCTGAGCTCCTGGCTTCTTTTCGTGAACGCATTCACCTTCTTTTGAAGATCTAGTATTAGGTGAGCTCGGAGCCGGTTCTTCTCTAAATGTTGCTTCGTCTGAGCTTAAAGCTTCTTTCCTGGATTTAATAAATTTTAAAAATGGAAGGACATGTAGTGAGGGTTCAGGAAAGTCGGAGTCCGTCTCTTCGTTTTTTTGTTGAGATGATTTTTTCTTTATTGTCTATGTCTTCCGCTGTAACCTCAAGAGGATACAGTTGATTTAGTGATCGTTCCAACGTGGAGATTGAAACGAACTCCTGATTCAATGTTTCCTTCAATTGTTTACTCGGAATGAGCTCCACAATTCCCAGAGGCCATGTGCGTCTTGGCAGCATTTCTTGTCCGACGAGAACAATATCTCCTTGTTTAGGATCTCGAAGAGCATCCCTTGTATTAGGCCTGTCTTTTGTCTTTCCAGAAACAGGAGATATGAGTCAATGTCGACCAGATTTGCCACAACTTTGCAACTGTTGTTTCAACTCTGGCTAATTGTCTTCTCATTTGCTCTGTTGATCGAGTTCGGAGAATATTCCATCGGTTCGTCTAGATCAACATATTCGGTGCATCTAGCTGATTTGGTAGTAGAAAGTCGATTGTGGCGGAGAGCCGTCAGATCATTGGGATCTGTGTTGTCTGGTGTAAGTGGACGGTTGTTAATCATCCCTTGGTCACCTGTCCGTGCTGGGAGAGCTAGAAGAAGGTTAATTTTTTTGCCAATAGTCTTGCGAAGTTTAGGTGCTTCGCAATTCAAACAATCCTCTCGTACACTACCTCCTTACCAAGGGGCGAATGGAGTGATGTTGTGTACGTGAATTTCGTCATTTGGCTAAAAAGCAAATCATTGAGTAGCTTGGACTGCATTAAGTCTGATGTCTAGGTTGACCATTTGGTGGCCTAGTGTAATGTTGGTGCATTGTCACAGTAGATATGGGGCGGTACACCACATGAACTGGAGATTGCTTTGAGTGCGAGAAAGTAGTTGGCTGTAGTAGCGTCTGGAATGAGTTCAAGAAGGCTAGGCTCTAGTCTTCAGACAAGTATAGATTAGAGCATAGGCTTTACCTAGCTTGTCATCGTCTGTCTTGTATTGTATTGTACCCAAATAGTCGAGTCCTACATGGTCGAATGGTGCAGAAGGTCCAGTACTGCAGTTTTGTAGTCGTGTGTCGTAATTGTATTTAAAGGGTCGTGCTTTCACCTTTTTACAGTTCACGCACTGAGTAATTGTAGTTCTTGCAATTTTGCGATCATCTCTGATCCAAAAGTGCAGTCTTACTGTAGTGGTTGCCAAATAGTGTAATGGGAAGTAGGTATTGCGTTATCTGACATCTTCCACAATTAGACACAATCAGATGTCGGATGGGGTCCCCCCACTATCCAATGATGTTTGTTTCCGTCCTCGTCTACTGGTTTACGCAATGTGTCTTGCAAAGTGGAAAACGTCTGTTACAACTGGAGATTTAAGTTGTGTCAAAAAATGGCTGAATCAGTATGATTTTGTCTCGTCTTTGAATTCGAGATTCGGTGTTTATTGTTGCATTGACTTAGCATAAGATTTCCTGTTATATGACTCGGTGACGAGCAAAGCATGTACCATTGTTGATGCAGAAGCGTTTGACTTCATTCGCACCCATTGTGCTCGTTTGAAGTGGATGGTCTTTTTTGAAGGGAGGGCACGGATCTCCATCGAGAAATTCTTGCCAGCGCCATTCTCCACGAGTCTGGAAGTAGTATTACCCGGTCTTTTGTTGAAAATGCGGGTTCAGGAGGTTTTCCTTTGGTTTTCTGTCCCGTTGGACATCAACCAAAGTACGTCTATGCCAATCTTCCGCGCAGTTGTCAGATGTTTTTTGAGGCTTACGATTGGATAGTCAGCCCGTCTGGGTCGTATTACGTCACGCGGAGTCAGCTCGGTATCACCTTGAGAGTAACCGTATAGTCTTGATCTTTAATTATCATGTCTTTGGATTTTACGCCGCTGAATTCGGGTTTAACAGTTTCCCCAACAACAAGTCTTTAATCGTCGATAGTTATGTCTGTCACGCACAAGAAATAACTATCATTTTCTGTATGGCCAGATTAGTCGTGGTTCGTATGATATCTAAATTCAAAATTGGCGTACCTGTATCCTTTGCCTTCTCGACGCCGTCCTTGAACATCTCATCGAGGGTATCCGGCAATGAATTGGCTTCGGCAATGTATTTCAGTTTGTATTGTAAAGATCCTAAAATGATGTAATCCATATGCTGCTGCATGTCACAATCGATATTGGCGTCAATCCAGTCGAAGACTTTTTGCTTCAAGTCTTCAGTCTTAACAACGGTGCGGCGTCAGACAATGCTATGGATGATGAAGCGGAGAATGGGGTCCTGGATTCCCTTCCCTAGCTGCCACCATCCCGGAGTCGGGATCAAGACTAGTTCCCCGCGACCTCCAAGATGAAAAGTTATTCTTCGTTGAAAACCGAGAAACTTGTTATCTAAAATCAATAATTGGTTAAGAAGAAATAGACAAAATGCATTTTGAGATTAAGTAAAAGACTTAGAGATTAGGAAAGAAAGATGGGGATGAGGACTCAACTTGAGTGATAAGAAAAAAAGGCATTTTAATATAAGATTCTACAATAGGGATTGGGAAAGGTGTGCCGTGGCCTAATATAGGTTTGGTGGTACAATAAATAGGGGAAGTAATGACCCAATATGGGTTCCTTGGGGGGATTATTAAATGTTAGCCAATATGGGTGAATTATTAATTACTCATATTGGCAGGGGAATGTCGGTGAGGGCTAAGAGTTCCCTGTATCTGTTGCTTGATAGTCATGTTCCGGAGGGGACTTGTGTAGAGTAATTTGGTTTAAAGTAATTTGATGTAGAGTAAGTATTTGGTGTAGAGTAGGTTTTGGTGTAGAGGAGATTTTGGTGTAAAGTAATTTGGTGTAGAGTAATTGCTGAAGAGGAGGGATGGAGGGATTTCAACACCGACTGGTCGTGAATTCGGCCCTTAATTGGGAGGGTAGGGGACAATAGAAAGAAAGAGGCTACCGTGTGGACCAATTTCCCCCAGCAGGGACCTAGTTGGGATTGTTTTCACTTGAACACGAAAAGACAATGGGGGTTGGGAAAGTTAATAGGGACAAAGGAGCAAAACGGAACGCCCATTCCCGCATCGAATTGATAGGCACCGAACCCAAACTCTCCTGCCGCTGCAGCAGTCAGGGATCCGACGCTCCACGCTCTCTCATCGCGACTGGAGACCAAGTTTTCTCTTACAGTCTTTTTTTTCTAGTGGCGCCGGTTACTTACTCCATTGCCAACTAGCTCGAGTCGGTGGTAGAAGTCAGAAGTCAAATGCTTGCGGACGTGGAATATAGAACATGTTTGAAATTAAAGAGGGTGGTTTAAGTCTTGTTTTTTTTGAGATCCCTATGGATGAATTTTGGTTTATTTTTTAATTTGAAAGGTTAAAAGATGTACAACAAATAATTTTTAATGATGTATAATTTTTGGTGAAGGTACTAGTTGAAAAATATAAAGAATTATTGAGAGTTTAAAATTGGGAAGTGGTGTAGAAAACGATTTTGTTAAAATATATTTTTGGAATTTATGCAATTTTATAATTTTCAAGGATTTTTTAAATTTTTTAGGAAGTTTTAAAAGGGGGTAAATAATCTAACTGTTGGGTCCCCGCGTCCTCCAACGAGCAAAACCTCTATCCATCCAGAGTTCTTGTCTACCCGGCTTGTCGCCTCTTCCGCCTTTTCTTCTTGTCGTTCTAGCACACAAGAGACTGTGCACTATAGTCTTTCCGTTGCAGTCAGCGAGCCGCCAGCAGTCGCATCGTTAATGGCACCTTTGCCACTGTATTGAACGCTGTGAGCTGTTTTAAGTGCTATTATAGTCTGTAAAAACAGGAAATTTTGTACTGGATCGTCTTTCGTCTTTCGACTTGAACCATATTAACAGCCGAGGTTTATTAAATCAAGGAACAAATAACTCAACAATTTGGTATCAGATACCGGTGAGGAGTGGTGAGGGGGATTTCAAAAAATTTAACTCCAACATAAAAATTTCGTGATCGAATAACGAGATATTCGATGGGGATTGTCCTCGTGCCAATCTTGGTCCTTGGTTGGTATCGGCGTCTGACCGGCTAGTGTTGTTGCTATAGCTGTTGCTGGAGTTGGCGGAGGTCCAAATCAGTTGTGGAGCAGGAACGCGATGAGTGGTGGTGTGAACTCCTGTCCGGCTGGTACGAGTTGTGGTGGAGGTTGCTCTTCGGATGGTGATGGCGTGTGCCAGCATCGTATCCTCCAGGGAGACTTCCATCGCGAGGGATGTTGATCGTGCGTGCACCACCGCGCATCTATTCCCCTGTCGTACAGAACGACGTGATCCGAGGATTGGATCCACACTTCCTGGGAGCAAGATTGTGGAGCCGTCGCAGTCGTCGGGCCATTTGGGTCGCGGCCGGTCTCGGGGGGCTGGGCCCGTACTTCCAGGGGCAACGTTGAGAAACCAGTCTTGGAAGAACTCGGATGGAGATGTGTCTTCGGTGCGAGCGGCTCGGGTCGAACGGTCTGAGAAGATTTTACCGAAAATTAATAAAGTATATGGAAAAATTGGATAAATTTTTAGAATTTTGAAAGAATTGATTGAAAATGTGGATAAATTGAATTTTTTAAAATGAGAAAATTTTTTAGAGATAATAATAATTTTTATATCCAATTTTTAAATAAAATCGACTTCCTTCTCGAGCAGTCTGGCGCTTCGTCGATGTTACTGGTAGGATCCACTCCCACACAAGCTGTCAACTTACGTACTACCAATGAATTGCAGTATAATGTGTCTATGAGATGCAAAACGACGAGAAATAGCGAATCATAAGTCGGGGAAAGTCGAAATTGGGCTCTATATCGGGAGCATGAGTTTGCCAAACATCACCTCCCTCGCGTCTGTGGGCTCGCGAGCCGCCCTTGTGTACGATTTTAGGGGTAATTTTGAATTTTTAGACTCTTAAATTATTTTTAAAGAAAGTTTGGTAGATAATGGGACGGGGGATGCTTAAATGATGTGTACCTGTCGTCTATCAAGTCTGTCGACTATCGAAAACGTCGAGTCGTCGAAGTTCATATTGAATCGTCTCTTCACGGCCCGGCGAGGGGTACATGAGAATTCTCTACCGTATATTTGGCTGACTGCGTGCTCAACGTTGATTCCACTCAGTTTCAAGTTTGGTACACTTCACGCGTACTGCACACAGTTTAATTGACGAAATTTCGCGAAAATTAACAGAAGATTTTTTTCGGAATTACAGAGCTGAACTCTATTGATAAAAAAACTATCAAATTTTCATCGAATTTGTGAAACATCGTAAGGAAGATCTTTTCTTCACTATATTCAAGGAAAATCGATATTTCGCTTTTCACAGACGAATGTTGTCTCATTTTACTCGATGAAAGTTTCTGATGAGCTTCATCGATTTTTGAGATAAAAATGCGATTTGTTGATAAATGGATCAGTTATATAAAGAAACAACATATATTGGACACTCTGAGATTACTTTTTGAGAATCAATTCTTTATTTTTCTGTCATTTTAAATTAAACATTGAAATAAAAATATTAAATAAATAATAAAAAAAACAGAAAATCGATATATTACTTTCTCTTCGGAATTTCACCTTTTTTGGATTTATTCTGTAATAAACTCTCTTCTTCGAATTTGGTGTGTCCACGTGGCAGACGAAGAAGAATCTGCTGCACTCCTTCTTGCTTGCCCACAACTTTCTCGAATTTTCTAAAATTTTAAATTTATGGAAATTGTCATTTCACCATTCCACTCACTTCAGCTGATACTGCATTTCGGAAGTTGATCGGATACTGGTGGAGCAACGGATGGCTTCCAGTGATTGGCTGGCTTGTCGAGCAAGTTGTGTGCTTGCCTGAAATAATTTTTGATTTCAATTTTGAGTTGATCTAAAGCAGTAAACCTACCACCGGGTTCGTACGAGAAGGAGCATTACTTGGTAGACCACGGAATCTTATCGTTGAACTGCCTCCAAATGCAATAGAAGTTTGTACGTTTGGTGAGAAGTCGGGCTGAAAATTTTCAAAATTTGACTTTTCGAGAAAAATAACTCACCACAGCATTTCGAGATTTTGTCGATTGTGGAAGCCTTTTGAGTCCTGGAGCAAGAATTGATTTTTTTGTCGCTAAATTTTTTCTTTGTTGTGCAGCCGTGACGTCCCGAATAACTACTTTTGGGTCCCGAAGATTATTTTGCGAAGAGTCAGAATTGGCAGAACTGTTGCATGGGTAACACGACGGAAAGAGCGGGAATGGACGTGTTCTGAAATAGTTGTGTTTTTAAGAATGCAGAAATGTTTTTCTGTACCAAAATTAGCATAGTCTTGTCATTCATCATGTTAAGACACATGAGCTCTCCCAGAACATGGATGTAACGCCTTTTCTTGTCCCGGTAATTGCAAAATCTCCTCTCAAGTGCATTAAAAATCGCGTGGACAGATTCAACTCCTTGTTCTGTGATCCTTCCAATCTCACATCTGCCATTTGTGGTGAATGGTAGACCAACGAGCAGGTGCAGCTTTAAAATAATTGTTTCTTCGGGAACCGCTACTTTCAAATACTCCACAAATCCCCGAATCGAATTTTGAAGTATTAAGACGTGGGAATCATTTAAAAACTTGTTTCCCGAAAGTGACATAATAGTTGAAAGCTTTCCCATTGCTGATTTGTGCTCAATCCGAGCAACATTGGTCATAAATTTGCGCCAAAAATTTAGAAAGACCCATCCTACCAGCCGGCGTTAGCAGCAATTTCAAATAGTTTCCGGAAAAGGATTGGCAACCAAGCCTGCACCTTGTCCGCTCCAAACTTAGCCCAACCAGTCCCATTTTTTCAAGTCTCCCTCGGGAGTACTATTCACAATTATCTCGAGCAACAATTTTTTCGATTGAAGTGCTTTAGTTCAGCATGCGACTCTTCATTCCGGCGGCTCCTTGATACTTTTCTTCCGCACTTTTAATTTAACAGCGATTTTTAGAGTTGCTTTTCGTGTTTTCAGGATCGGAAGTAGTGTTACCTATCTAGATTATCAGAATATAGAGGTGATTGAAGACCTATATTTGTCAAAAATACCCATGATAATGCGCAGAAGAGGAATCAAATAGGATCGCAACAGTGTGTAGGAGGAGTACATCCTTTGCGAACACACGACATTTTCACAACAAGCTTTAAGATCGATTGTTCGTGGGTGGACATATGATCAGTTCTAACTCATCAACATTCATATCCTTGATTTTCATCCTCTCTTCAGCTCCACTTTGGTTATGGACTGTGCTGCAAAATCCATTTAGGAGAAAGGTGCGAAATTGTGGGATGAATGTCCTGTTTGGTGTAATATCAGATTGAAACTTGCTATCTCCAGTTTCACGGAATTTGCACAATTACTTTTGCGGTTTTTTGAACTCGACGTCTTTGTCCAAATATCAAATTTTCGTTATCTTGACCTGCTCAAGAACGTCCGCCGAATGAACTTTTTCAGAGACGAATACTTGTCGGATCCGTCATATACTGCAATTACCATAACGTGTCTCGAAGAATACGGTCGAGATACGTTTCCGATTACAAATGCCAACTTTGTGCTTCCACCTCCAGCGTCACCAACGACTCCAATCTTACTCCTTTCGTGTCTACGTCGTCCCTACAAATTGATTTGAATTGCATAGAAGCTCTATACGAAAGGACAACTGTCTGCAATTTTCACTGCACAATGGTAATCACTTTTCCTTTATTGTCGAACGAAGTGGAAGCTTTGAAACTGGAGATCATTGATACCAAATGGATTGACAAATCTGTGGTGTTTACCGATGGAAGCAAATCATAGAATGGCAGTATCGTCAAATAGTTTTTGATTATTCTGTCCATCTGACTTAGAGATAATCCGCATTGTTATTGATAAAAAGTCAACGGCGTCAAACTTTGAAGCGTGTGTTTGTAGATTTTTCTGATTCTCTTCTGAATTCAGGAATTTTGTGAATTTGGTTTCGAATAAATGGTCCGACCTCATAGGTTCGTGTTGAAGCAAGTGAAGAGCTTTGCGAAATCGATTTTTGATACAACTTCTAGTTCTTGCTTCTTAGATTCGATTAACTTTAAAAGCTGATTTTTTAAGGCTAATTTTCAACTGACTATCTTCGGCGTTACTCAGAACCATGGCTTTGCCACTTATCTTCACATCTGCACAGCTTCTCACCAATCGACCCTAAACCACTGACGATCGTTGGTATATTGTATACTTCCATCTGCACGAATGAATTAGATGCTCTTATAGTGAAATTTTCATGGCGGACTATTTGCATTTACTCTCTTCCGAAAACGCCGCAAACTCATCAATCCGCTTTTTGTAGATTATTTCTTATGATATTTCATTTTTTTCATTTTTCAGTCGTTCTATCGTTAGTCGGAGCATTTTGATCTGCGGAATTTGCTCAACATTGGAGATTTGCATATTCGAACCCTCGGTGGAACGAGTTTCGTACAGGTGTCGGTGGAAATACGGGATTGGAGAATCTCTCCAGCAATAATATTAGTTTTGAAATATTGAAAAAAATTACATTGTGAGAAGAAGTCGGAATTTCGTCATACGAAAATCCATTTCCACGTCTCTCGTCAGAATTCTAGCTTCGTATATTGAAACAATTCTGAGGACCGGCATGTAGTTGCGGAGCATACTGTAGAAGCAATGCACTCGGGATGGTTATTTGGGAGTTTCGATCCTCTGAACTGATTTCACCCTGATTAGCCTGTGGCGACGCTACACTCTGAAAATCACGTTTTCGGAGTTAGAACAAACTCCAACTTAATTAAAGTTGACAAATTCCAATTGAGCTGAACGAGCCTCCACCTTCGAATTGTTCTTCCTCTTCAGTTTGATCTTTTGAAACTCCATTAGTACTGTTCCTTGCGCTCTGGGCATTTGCTAAAAGAAGGCCTGCACAAGATTTTTCTTTTCTTTTTTGTTTGAAGTATATCCGCTTTTGTCATCTGGAAATATTGCATGAATATTTTAAGGGAAACAATTTTTAAATATCGATTTTCACGAAATTTGAAAAAATCAATATTTGGGCGCAGATACTGAGCTGAGTGTTTCGAATCTCGAATCAGCATGCTTTAATTTCCATATTTTAGGATCTTTTTAAAAAATCTGCCAACAGTTTTTGAAAAAAAAAATACTTTTCGTTCAGAATGTACTGATTTTCCAGTGATTTTCACGAAATTTGAAAAAATCAATATTTTAGGCGCATGATATTGAGATGAAAGTTTTGAGAATAAGCCAGCATGCCTTTAGATTTTAGGATCTGTTTTTAAAAAATCTGGACCAACAGTTTTCGAAAAAATTTAATTTTTGTTCAGAAATGTGAATATCTAACTATCGAAAAAAAAAATTGCAAAATCCGTCGGCTGAACATACAAAACTTATCAATTGGTGAATCATCAGCATATTTCAGTGTATAGATTAAAAACGGTTTCAAAAATTCTGAGACTAATTTTTGTTGAGAAAAATAATTAGTTTTCGTTCGAATTATCGATTTTTCACGAAATGCCAAAACATTAATCTTGGGGCCCATGCTAAAAGCCTGAGTCTTTCAATATAGCATGATTTTTTCGATATTCTAAGACGTTTGAAAAAAATCTGGACCAACAGTTCTTGAGGAAAGTAATCTATTTTTTATACAAAAATTATGTGCTGTGATTTTTTACTAAAAAAAAGAATCAAGTTGAGCCCATGCTATACGCCTAAATTAAAATTCAGAACCGCCATGGATGTATTTATACCATAGGCTCTTCGCAATAAAAAAAATCTGGACCAACAGTTTTTGAGATATGAAAAAAAACAACTCACTTTTTGACGTTTTAAGGTTTTTTCCCGGATGATGCTGTCGATTTTGGCGACTGGTGTCTTTCGCTGAAAATATTATTTTTATTTCAATTTTTAACGAAGAAAACAAGAAAAAACGACGAGAATCAAAAAACACGAAAAAGACGTCGAAAAACTCCCGCTACCTCATGAAAATAAAGCACTGCAGCCGCTGGACTTGTTTTCTCAACTTGCGGTATAGGCCATGTCCCGTTCAGAAGGCGTGCCGTGTCTTGTCGTGGCGGTGTGAAGTGTGTTGGTGTTAACGCAGCGTGTGAATACGGTAGGCTGCTGCAGATGTGGTGTGAGCTGTAAAAAATCGAAATAATTCAAGAAAAATTTACGACGATTTTCGTATTTTGAGAAGAAGAAAATTTTAGAAGGAATCACGAAAATTCGAGAGAAAAAATGATCAAATTCAGTCTCAGAAGCGAAAAGTGAACTGCTTTGTCTAGAAAACAGCGGTTGCTCGTGAGAAAAAATGTTTAAAATTGAAGAAGATCAACAAAAAAAAGACACGTAGACGTGTTTTTAAAGTTCCCGTCGTGGCCGCGTCGCCGCGCCGAGTGCGCACTTTTGTAGTAGACTCCGCCCCCTTTTTTCTTGGCGCCGTGCTTTTTAAGGGGAGCGTTTGTGGTTGAAATAATCGATTTTCGACGAGAAAATAGACTAAATCAAGACCTATGGTGAATCTGATTAAAGGCATATTAACTTTGTAAACACAATTAACTAGAAGAGGAATCGTTCTATAACCGAATATACTCAAAGGGTCGCTGACTTCCCCCGGTCTAGAGTCCCAGGTTCATCTTCGAGCTGTTTCCTGAGAAATTGTACAGGATTTGTCTGAGTCGTGAACTGAACACGCTTTTCAGGTAAACGTCGTCTGGCTGTCCTGGAAATCAAATGTTAGTCTTTGTATCGATGGCAAACATGTCTCAAGGGAGGAAATAGTCGTAAAGTCGGTCGATGCACCATGTTGTGGCACCACGGAGTGGCGGAAGACCAAACTTTAGCCTCAAGAGGAACGCAACGTAGACTATGTCAGAGGTACAGCATTCGTGGATCCAATTTGTATATGTATTTCTGGAAAGAACAGAACACAGTGTTAATAATGTTTATTACTCCAAAGGGGAGATAATCTACAGAGCATAGCGAGTGGGTGCCGTCGTACACAAAGAGGGAATTGTCTGGTGTGAGAATATCACATCTTGGCATGCGGCTTTAGTCTGAAAGGGTCGAGTTGATGTATGAATAGTCAGGGTCTTTTTGCAGACTCGTAGAATAATGTCGTCAACTACACTTTCCAAATAAAGGGAGGGAAAGGTAGGAAACGTCGGCATTTAGTCTGGCTGGGAGCTGTCAATAACGGGGGGGGGGGGGTGGGGGGAAGAGACCAGCAAAACCGAACCAAGAGTGGGGAGGAGTGTTCCTTTCGTGCCACCGACGCTGCAGCTCGCTCCGTATCGTCGATTGAGTCGCCGCGCAGCCAATCGTGGCTACTGGGCGCGAGTGTCACTCTCGTTAGAGAGCGGCGCAAGAGACGCAGAACTGAATACAGTAAACTTCTCCTAGCTGGTAAGCTTAAAGCTGGTCTTAAAAGGTCGAATTGAATGTACCCCTCGCTCGGAGAACTGCTGAAGCAGTCGAGAGCGAGACATTGTGATGGGCGATACAGTTTCAGAGTTCACAACAAACAAACTTACTGGCACTTACGTATAAAATATTGGGTTTCGTCGCGCCCCCTCCAAATGTTTTAAAACGATTTAAAACATAATTTATACTGTTTCACTACCAATGAAAGTTCATGGTTGATAACATAAATCCCCACATTTCAGAAAAATGGATAAGCAGACAAAATATTAATGAACTCATAATTTTCAATTAGCCAGCTATTGTTTCGGTGTATTACCAGAAAACAAATTTAAGTGATCTTACTCTCAACTCCAACCGAGTATCTAATTGATTAGACACATTTTTTACAATCTTAGCTGACAATTGTGCGATTTTTTAGATGAAGATTTTGTCAATAAGCACGCTGAAAATAAAAAAGCGAGGTAATTTCACGCTCGCGGAATTGTGAGCCAGTGGCTGCCTCCTTAGATTAATTTGTTACATAATTTTTCAGCCATACTTGGACCATAAATTTTGGCGACCATTACGGCATTATAATTTTGAACTGCAAACAAAACATGCAAATATATACGTTTGATAGGAATTCGCACTAAAGCTAAATTATTGAAATTCGTCAGCTTTTATTTTCATTTCTTATATTTTGACTAATTTTCAAATCGAATTATTGAAAATGAGAATTTTTAATTCATATTTCGTCAAAATTAGTGAACGCGTGAACGGAGACGGCGAAGGCGGGCCGGCGAGAGGCCGGCGTGGGAGAAGGCCGCCCGCGTTTAGCGCGCTCACTTAGCTGGAAACCCTAAGTTTCTCCAATTAAATGAACTTTCAGGTGATATACATTTTTCCTTTAGGATAAGAAAAGAACATTTCCTAAGCCTGACAATACAAAAACGTGGTTTTTAACACGTTTTTATTTTTCATAACTTAAAAAAATACTATGCATTAACGCTAAATGAGGGCATGGTAATACACAAATACCGGCAAACGGTGTTTCGCTAAATCAAATATTGAGACAGAAAAAACAAAAATATGATGAATTCTCTTTGTTCTTACCAAAATCCATCAAAATTTAGCAATTTTTTACAGTTATATTTGGTCATTACGATATGCCCATTTTCTATTAATATGAAAGAAACAATTGAAACTGATACACCTTGTCCGTCGACTATTGGGCATCGACAGATGGTCTTCTCAAAATCCAAAAAATTGGTGGAACTCTCTTGCACGAGGAGGACGCTCTGCAGGGGTCGTTCTCCTTTGCAAAGGATGGCATTCCATTCATTTGTCTATACAACCTCTCATCTTTCATGCAAACCGACATTCCCCACATACTCGAAATCCCAATTATGTAGGAAGTTCTTGTTTCTTAAACTAAAATTAGCCAACTATTTTCTAGAAATAATCTATGAAAGACCGAAATACCTTTTACCCTTGAATGACATCAAAAGTTGAAAACTGTTTTATCTGGTAAATATTCAGTCAATAATAACAGGGCAAAAATTTCCTATTTGTAAGACGGTTTGCCAGCAGCCCTACTGATGCAATGTAAGCTAGAGGTCCTACAAAAAATACCTGAATTTTGTGTCTGGAGCCTTTGCTAACTACAAATCGTAGGCAAAAGAACACATTTGTGTACAAAAAAGTATGCAAGCAAAAGAGACACCGTAGGCAGGCAAAAGATTCACGCCATAAAAGAGAGATAGCACCCGCGGTGCTAATCATTCTACTAGTGGCTTGAAGCCTCTGTTTGATAAAAGTAACATTTTAAGCATTGTTTAGGGTTCGATTTTTCTAACAAATAAAATTCATATCATTACTTATACAGTGCGTGCATGTTGTTCATTCCACGCCCAAAGTTTTTAATCATGGCAGTTTCTGAGAGTGAAATTTCAGGTGAGCAAAAAGTATTGAAAACCTATTCACAATGAAAAACCTAAACTCAAGAAATGTTGCGATTATATCTCGATGTGAAAAATAAGACAATCAAAAATTGGGCATGGCACTTCTATATGCCACCTCGGATTTTTTTATGATTTCTTATGATTTTAGACTATTAACTTTTTATTCAAACAAGTAATTCGAATTCGTATACATTCCTCAGTGCTAAATAACTATTCCTGTAACTTCTCCCAAAGACGATAGGATGATCAAAATATGGGGATATGTTCTAGGAGTTACTAATTAAACATAGTTGTGAATATTGGTTCACATTTGTGGATTTTTAGCGTCGCCGCTAAGAGGGTCATATTTGCCCCAGCCGTTTTTGGTGAAAACACTATTTCTCTTTTTTTTCGCGGTGCCATTCAAGTTGAGAAATTTCAGGCATCTCTCGAACCTGCACGGAAAGATGAATACTGCAGATAAACCTCTAGACTAGGAAAACAATTGGAAGTTTCTTAAAAGTTTGGAATTTTAATACTAGAATTTTCTGAAAAATTTCAGAAAAAAAGAGACTTTCAAGAAACTTCTGAAAACTTCGAGAAAGTTCTGGAATGTTCCAGCGCCGATTTTTCTAAAAAGTAACATATGCCGTTCCCGGTAGAACAATGTTTTGAGTATATGCCAGAATCTTACTAAAGTAAAATAGTTTGTTTTAAATAAGAGTCTGATACTCCAAAAATATTATGAAATTTCAAAAAAATTAAATTTAATAGGTTTGCAATTCGATTGAAGACCTGAAAAAATGTTAGAAATTTAGAAATTGTTCATTTTGAAAGTATTCGAAATACTGTTAGATTATTCATGAGACTGATAATGTTATCAGTTTTTTTTATTTGAAAGCTTTCTAAGAGTTTCATATGAACATCGAAATATTTTTACTTTAAAGAAACAATTGCTCCTGGAAAATTTTCACTGCGAAAACCTGGCTACAGACATCTTATGATGCTCATACACTTCCTGGACACTGAAAAAAAAAAACGTTTCATCTGCAAAGAAAAACTTAGAACATATTTCAATAATTTACTTTAGTGCAAATTCCTAGTATACATAGATGTATATTTACTTGTTTGCAGTTCAAAAAATTATAACCGTAATCAAGAATGGTCGCCTTGAGAGTTATGGTCCACGTTATGGCTGCAAAATAATGTAATAACTTGAAAATCTAGGCAGCCACTGGCTCTACTCGAGCGTAAAATTACTCACTTTTTTATTTTCAGGCGTGCTCTTATTGACAAAATCTTAAAAAAGATGTTCGCACAATTGTCAGCAAGATTGTAAAAAATGTGTCTTAATCAATTAAATACTGTGTTGGAGTTGAGAGTCACTTGGATTAAATTTGTTTCCTGCTAATACACCGATAAAGCTGGCTGATTTCGTTGAAAATTATGAGTTCATTAATAACTTTTTTTCTGCTTCTCCATTTGTCTGAAAATGTGGGTTTAAGTTATCAACCATGAAAAACTTATTCTTTCGTCAGTTGTAAAAAAAACGGTATAAATTATGTTTCACATCGTTTTTAAAACATTAGGAGGGGGAGCGACGAAACCCATAATATTATTAATACGTAAGTGCCAGTTAGACTGATGGCATTGATAACATTTATCAAAAAAAATTAATAAAAATTTGCCGCCAAATAAACAAAAACTTAGAGGTCGCCTTTTCAAACAAAAAAGAGAATCAGCCTGATACAGCGAACTGATATCCCTAATTATAGACAGGTATCAAAAATTGTGTTGAATTTTACTTTTATTCGCTCCGCTTTTTTCAGCTGATAAATAAATTGTTCAGCGAAGAAAGAGTTTTGCACAAAATTCGAAATGAGCAAAATACAAATTCACAGTTTCAAGACTTGTAATGTTAATTGAAGAACTCCAAAAATCAATATTCATTAACAATCAAGTAGATCCTGAACTTTCGCTAATTCGAACAGCCTCGTCGATGCACTTGCTCGTTTCTTATAAATGCACTGGAGATACAACAAGGTGAAACACTTATTCGTGTAAGTTGAAGTCAATTGTTAAAAACCTGGTTTTTTTTCTCGCCGCTTCCGGATCTGTTAACTACCAAAAAATTTAATTTTATTTTGATGTTGATCGAATTTTGACCGGTAAGGGAAATATTTCAACTTAACCCCGGACTTTCGAATGACGACTCTAAAAAAGAGCTAAGAGCCGCAGAGGATCAATTTGAGCTGGGGAAAAGTCGATCTGAGAAGTGTTTCAGACAAATTTTCATCAAAATAGGTGGTTCAGAACTTGCCTTTAAAAAGTGTTTTCTGAGTCTGTTGAAGTTTTTTATGCTTTTTGCTTGTTATCGTGGAAACAATATGAGAAGTGGTTATCAAGCAATTAAACCAATTTTTAATGTTTTGTACTCAGCTGTAACATTTTCAGATTTTCAGATCTTGTGTAAAAAAGTAAATGTGAAAGTCTACAAGCTTTTTGTCGAACCGATTAAGAAAAACGAAAATTCGTGCGGAGTGGATTCTGTCGAATTATACAATGATCACTTCGATTGCTTGCTTGGAGTAGATTGTAAGTCAATTTTTGACATGAGCGCCCGTTTTTATTCTGAGTAAAATATATGGCTTTTGAACTACTGATTTGACATTCGTGATTTATGGACTCGTTGAAACAATCATTTTTGCTGTGGTTGTTAAATATGTCGAGACATTCATGGAAATAAAAGCTGTATAGTTCATAGTATTCAACTTCAATAGGTGGAAATTCGAATATACCGCAGCAGTTTTTGAATTTGATGTTGGAAAACTTTGGAGTTGATGAGACATGATCGGTGACAGATTAAAAGAACTACTCATGCGCATATCTTCGATTGAGCAATTTCGGAATTGAAGAGTTGCGAATATCGGGGTCCAGAAGAGCGAGTATTTGGAGAATTAAAAATAACTAGAAATCATAAATCAGATCAGGGTATCTCCACATCATTACAAAGCGCTGGAAATGAAAGACTGGTGAGTCTAAATTGATGCATTTGTAATGAACACCGTTGAAGAGATATTTGAATCTCTCCTTTAGTTTTTCTATTATAACAGTACACGTATTGTAACATGTTCTCAAAAGAGTGAATTCTCGTGTTTTTCATACTTAGATAGTCTCTCCATTCCTTCACTTAAAGTTATCCCACAAACAGCCCACTGCGATCAATGTCATGGAAACTTTATTCTCGTTTTTTTCGTTGTTCTCGCTGAGAGGAAAAAAGCGAATAATTGGATAGGTTGAATAACGGAAAATTTCTTCAATTTTCCGAAAAACCAAAAATCGTTTAGAATATTAAAAAAATCAAATTTGATGAAAAACTCAGACACTCTTGACATGATATGCTCAGGAACGTTATAAAGATCTTTTTACAGGTTATCGGACCGACATATACGAATGAAGCAACTAGGGCGGTACGTAGTAGGTGCTCGAGGAAATTATTTCCTCAATTCATTGGTAACATGCACCCACTTTCACCGTTTTAATACTGGGAAAAGAGTTCCTTACAATCCCAAGACAGACTTGTGAATACCAGCTTATTTCAAAGTGGAATAAGGATTTCAGACTGGAGTTCCGGTTCGAAGCTTACAGTGGTCATTTTAAATGTTTAGTTCAAATATGGTCTATTTCATTTTGGTAACGTCAAACGACTTTTCGCGAGAAATGCCGTATTCAATGTACCCTTCAACACCCAACCCGTTTCGAGGGTTCTTGGAAAAAGTGGAGATCGATTTACAATTCTGAGGATATCCCGTTACTCGAAATGAACGAACAAATGAAAACGACTATTATACACAACCAATGGACATGTGTTTGCAAATGTTCAAAGAAACTGCCCAGCCATGAGTATGACTGTTCTTCCTAAAACGTATCTTCACATTACACGCCCGGAAAATATGGACAGAGTCAAAGCTAATCCGATTGACTGAACAAAACAGCCAGAGAAATGGAAGTGTCACATTCAACTACTATCAGCATGACAAAGGAGAAAAACATATTCCTCTCTAGAGGATATCCCAGACATTTTCAGTTCAAGAGCACGTCCTGTAGGTGAAAAACCACTAGGTTGTTGGTATCTCGATCGATATTTAACAAAGAAAATTTCAAGGATGGATTTGAGAAGTGACTGTCTGGTATGGAAAAAGCTTTCAAAAAATAAGAAATTCCGAAAATCGAAGAATGACTTTTGATATATTCTATACCATATATCTGAAAAAGTTCCAATGAGAGACATAGTACATGGGTGAAAACTGGATTTTTATTGCATTTCATGGATCTTATTGATTGATTTTATGAAGTGTATTTCTGTTATTACGAATAAAGCAAACAAATACACTGCCTCCGTCCAAACCATATAGCCTACGTCAGACAAGAGTTGGGCGCTGCCTAAAAAATGAAAAAAGGCGATCGTCAACTACCTCGTCGTCTCGAGGCGTCGCCGTCTTACCTGCTGAGCCATGTTGGTCGCGCGTAAAGAAGCACACTAGTAATAACATATCCTACTCATATTCTGATAGTTTTTTTTGATTAGGGGAAGTGTCAGATGTATCTGATTGATACGGTATTCTCACAGACCTTATTTCATGCGTTTTCAAGTGTGCTCACTAAGGATTCTAATAGTAAGTTCAGAAATCACAGAATTACTGGTAATTGGCAAGTTTGTTTCATGTCTTTCAATAACAGACAATTTTAAAATTTTGCATTTCAAAGGTACAGTTCAGTCTTAGATTTAAAATTTGATCCATGGGATTGACTGACTATTGTTTGCATACCAGCCGTTCGCAAGTATATGCGAGTGCTCCTACGGACGCGAACTCGAAATGAAGGTGAAATCTAAAATTTCTAAGCCTCGGAACGTTTTTCTCAGTCTTCCAGAAGTTTTTAAAGCAAATATTATATAACTAAGTTCTCAAAACTCGGTTACAAATGTTTTCGGCCGAAAGTAGACTATTTTGCAATATTTTGTTTTCGCAGAAAAATGGTACCCATCAGAGAGTGCGGAATGTGCCGAACGGCATGTGCCGATGTGCCGAAACAATTATTCCAGCACATCGGCATGTGCAGACCTCTCTTTGGTCGGCACATTTCGGCAGTCATTTCGATTCGGCACTGTCTGGAATGTACCAACCGTAAATTGATTTTTTAAAGAATTTTAAAAATGCAAAGAAACTTCAAAAAATTGATTAAAATTAATTTATCATTTCAACTTATAGTTTACTAACTTCACTATTAAGAAAACGCAGCATTTTGGGGTTATCCAACTGAATGTTCCCGCTTTTTCCTCCTGTGTCCCCCCTCTAGTCGCGATCCCACTGGGAGGAAAAATGCTTTTTCCTCTCAGACGGTTTTCGCATTTTTTAGCTGCGAAACTTCAGAACTGGGCTTAGGGCGGCGCATATATAGACTTTTTTTGATTTTTGGTACCAGACAAAGTTAAGGCCATTTTTATACTTATTTTACCAATTGGACCTGTGTTATATATGAGGTATGATATATCTTTGTGGTAAGCCAGATTCATGGTGAGTGATTAACGGCCTACAGAGTTGTAGCAAATCTCCTTCTGTTTAAAATTTTGTTAGTTGATCAATTCTTGGTATCATAGATTTTCACAGACTAACATAGCTGCGAAACTGGACAATTTCTTTATGGAAATTGCGTACACGAGACTTCTCTATTTTCCGCGTGGAGTATTAATACAAAAAATTGATCAACTAACGAAATTTAAAACAGCGAAACCTTGCTACAACTCTGTAACTAGTTGATCACTTACCATGACTGTGTCACCACATAGATATCATAGCTCAAAGTTTCCAATTCATTTTAAAAAAAACTATAAAAATTTAGAACTATTTTACTGGTCAAGCTGCCGCATTAAAAATTATGTTATTACAGCTTGGTATGTCAACAAATGTCTAACTGTGAAAATTAAAAGTAAGTTTGATTTCTTTAAAATATTTTTTGATAATTTTTTCATGTCCTGTGCAGATTTCAAATTTTGAAACAATACTTTTAATTCTCATATACGTTGAAAAATTTTTTATGACAAAGTGATCAATTAATAGCAAAGTTGTACTTTTCTTTGGATTAAGAAAAAAAAACTTTGTACTTGATCATTTTGCACATAAATTTATTCCACGGAGATATACGCATCCGAAGTGAATGAGTTTTCACTATCAATTATACTACGCGAAACCCTATGTTTTGGTCTGAAATCGCCATTGTTCAAGAATCCAAACTGAAAGAAACAACAAACATTGCAAGTAATTTTTTGTTATTTATTTAAATTGATGAACTTTTTGTTTTTTTTAAGAAGCTATATAGTATCTTTGCAAATGTGCCGAATGTACCGATTTTTTTTGGTTCGGCATGTACCGCGTGCCGAGAATAAATTGATTCGGAACAACCGCATGTGCCGATGTTATTAGCCGACATTTAAACAAGTGCCGAGCACATCTCTGTTGTACCCATCGTCTCGTCCAGATTTTTGTTAAATTCGAGTATGTGTGCGTCCAACCTTTTAAGAGTACTGTAATTTGAAACTTTCGTTCCTAATTTTCTTTGAACCTTTTCATTTTTTCCACTGGTTTTTATCCAATATTCATAGAAACCTTAAAAAGATAAAATTTTTCTAAAAATCGAAAGTTGAAGTTCCAGTACTCCTTAAAGGCACGTTACGGAATATCCACAACAAAACTTTGTCGTGGCGAGACCTGAGTATTATTACAGAGGAACGCAATAATTCGGAGAATGCGTTTAACACAACATATTTGACGCGCAAAATATCTCGTAGCGAAAACTACAGTCATTTTTTAAATGACTACTGGAGCACTGGTGTCGATTTACGGGCTAGATTTTTATTCATTTCTAAAAATTGAAGTCGGCACCCGGTAAATCGACACGACTGTAGTTATTTGAACAGGATTACTGGTTATCGGTACGAGATAATTTGCGCGTCAGATATTTTGTGCAATACGCAACCCTTATAAAGGACAAGTTCTGCTGGCCAGTGAATTGTCCCAAATTGAAATCCTTCTATTTTGAAAATTACTCAAAAGATCAAAGTGTCGATTTCGCCATTGCGCATGAGTAATTTCTGAATCTTGTTCGTTCTTTTGCACTTGGGTAAGAAGTTGCGCAGCCTTTGTTTTAGAGGGAAGTCAAACAATAGGACGTTAATTTCGCATTTGTGGCAACATAGTTGAAACTACGGTACTGTGTATGGGTACACCGTTTAAATTTTAAACAAAAATTTGTCTTGTTGAGACCGCAGAACATAGCTATTCTCAGTGTGTATTTGTCTAATAACCTGCCAATATTTGTAAATCTTTCAAAACTTCAATATTTGGCTCCAAAAATTATATTTTTAGCAAATGATCTACAAAAAGAATCCAATTTGACTGAAACTGTTAATATTTAAAAATCAAATGTATAATTTTTTTGCTCCAAAAACTGATTTTTCAAATAATCACAATTTCAATTCATTTAATTTCGATAAACACAAAAAAAAAGTATAGCATTTAAGAATTTCCTTGTTTAAGCTTCAACCGCGTAAGGGAAGGCCTCGTTGGCAATCGTCCTGCGTGTAACTTCGGCGGCGCTGAAAATTTTGAGGTTTTGCTTACATGGTATGTATTACTGATCCCTCAACTCCGCCATGCTCCGAGACGAAGTGGTATCTCTCCAGCATGGTGAACTCTGACGTGAGTCCAGTGAACCAGCCGTGTTGCAGTATACGACATCCCTCAGATACCGCAGTAATACGGATAGGGAAGGGTATGCAGATTTGGTAGACGTGGCGAGCCCTGTTGGATGTTGAGACTGACTTTTTGAAATGACTGGAAAAATAATTACAAGTCAACTTGCTGTCCGAAATTCATCATTACAAGCATTTGAATTGTTGAGCATGAGGAGATTCCGATTGCCATTCCGATGGGGTTGAGGCTCTTCCATTTCCTGAAAATTGTAATTTTAGACTTTTTAGATATCACAAAATCTGTTTAGGAAAAATACTAAGTTACAGTAAGAAAATTTTGCTCTGAATTGCTCATACAGGTTTTTAAGCTTGCACCCTGATTTGTTTAAATTCTTCAATCTTTGGATTCCTCGTGTACAAAAAATTCAATTCAGTCTCCTGGGCGTCGAATTGCGATGGAGCGCGTTTGCCGTGCGTTGGCGCAGCCGGTGGTTCAGTTGTAAGATGGGTGCAAACACGCTCCACAGAGTTTTCGATCCCCAGGAGACTGTGTCCAAGTAAACTGAGTGGTCGCTTTTTTGTTCAAAAAATGTGCCCCGCCCATTGGAAAAGCATGACCTTGTAATCGAAAATCCTTCAAATACGAATTCATTTACGAAACTGAAAAAGAATTAATTAACACTTTGTCCATTCGGTAAGATTCTTTCAGGTGTGACATCGTTTTCTCTTGTTACGAGCAATTTGGCTCAGGCACCGCCATCTGACCGGCCTAAGATAAGAATGTTTAAAAAAAGACGTGCATTGAGGAAGTTTAATATTCAAAACAGAAGAGACACATTCCAGATGAAAACAACTTACATTCTGAACGTTTCCTACGTCCGCCGATTCCTCTACGCCGTATCGATCGATTGAAAAATCGATCAGCTGACCGTTGAGCAGTACCTGGAGCGAGATGGTGATCGGAGCCACCGGTGGTGCAGTCTCAACGTCTGAAGAACCAGATCCGAAGGCATAGCTGTTCGATGGTGTTGGGTCGAATTTCTGAAAAAAGAATTGACCAATTTTTCATTTTTAATAGACTTCTAGGAAAAGGCCTAAAAAGGACAAAACGAGCCCCAACAATTTGAACAAAAGGGGTGAAATTTTATATTTTGTTAATTTTTCTGTATCACAATTTTGATTTTCAATCTATTGATATTTTGAATTCAATTTTTTCGGGAAAATATTGCAAAATTTAGCCATATTTCCTCAAAATAAACCAAAATTTGATTTTAAAAGTTTCCCTGGAGAATGAATTGTGAACTTTGGAACACCAAAATTAGCTCTAAAATTTCGAAAAAAACTGGGGAATTTCAACTTTCCGTATCTTTTAAGTTTGTCGGAATTTTTAAAAAATTTTATTACAGAAAACCACCAATAATTATAATCTTTTTTTTTTTAACCCGGGGTAATTTTTTTCGAGAAAATATCTTAACATTTAGTAATTTTTCCTCTTTTTAGGAGCTATTTGTTTTTTACTTTGATTGTTCCGTCAAAAACAATTTTAATTGTAAAGGCTTTTTTTTATGATTTTTCCAGAAAAACCGGTAAATGACACTATTACGGGAACAAAAAATTTGGAAAAAGGCACGTACTGAACATATCTGACGCAAAAATATCTTGTAGCGAAAACTACAATAATCCTTATCAAAAGGGTACTGTAGTGTCAAATTACGGGGCTCGATGTTCAGAAATTATTTTTTTGATCGAGCCCCGTAAATCGACACTACCAGTAGCCATTTGAAAAGTATTACTGACAATAGTTTTCGCTACGAGACCCTATTTTGCGCGTCGAAAAGTATGTTGTACAGTACGCAATTTCAGAATTTCGTGTTCCTGTAATAATAAAGATCTCCTGGCCACGACAAAGCGAAAAATTTTTATCGATTTTTCAGCAATTTTTCTCTTGTTTTCATAAAAATTGGGCAAAAACCGGAGGAAAAAAGTGACCAATTAATAAAAATCCCATGGCAACGAAAGGTGTTTGAAGCTACAGTACTCTTTAAAGAAGTGCACCTTCTTGGATTAACAAAATTTTGTCGTGGCGAGACGCTGGCATTTTTCCGGCGGAAAAGTCGCAAAATTAGCGATTTTGGGAATTTTTCGCGAGACAGCTGCAAACTCGACATGCGAGTTTATCCGTGCAGATGGCCAAAAGCCCTCCGTCGATCATATGACGAAGATTCCCTGGTGTTGCGAGCCCGACATTATGCTTCTGAACTATGAGATTGCCCGACTGTGGCACAAGACATTGCCCCACGAAGAGCATCGTGGATTTGGTGAGCTTCTCGAAGTCGCACGGCTTTACGAATCTGATCTTCGGAATTGAGTGGAGAGATGGTCCCGCCTCCAAGGACCTTACTCCCGATGCGCGGATAGATTGCGAAATCGATGAGCTGCCCGTTGAGCAGCACATCTTCGAGCGAAATGAAAATCGGAGCCACTGGTGGTGGGGTCTCATCGTAACGGATGAAATCCCGATGTTGAATCGGATAAAGCTGTCCGAGTCGGAGGAGGGGGTGTTGCTTCGTGGCGGTAGGGGAGAAGTAGCTTGACCGGCGGCTTTGGATTCTGGAAAATTTTAAAAAACTTGTTTATTATATTTTTATTTAAATCAGAATTTTTTATGCATTTATATTTTACCTTGTTCTTGTGAGTTTTTTTCGACAAAAGCGAGAAATCTGGGTCTAAATCGAACGACGCGCCCAGCATGTAGTACGAATCCGTTTTTACGATTCGGAGTCATTTAGACAGAAAAATGCATGAATATAGGTTAGCAGACGCTGAAAAATTGCGAATTTGGATTTTTTAACGGAAAAACGAGTGAAAATGGGACAAAAACATGTAAATTTTTTCAACGAAAATCGCGAAATTACCGCGTATCGATTCAAAATTGAATTTTTCGCTGTGGCCCGGGTTACGGTGATTTTTAAAGGCCCATGGTTGTTTTGAGACTGGTGAGGTATTGACGCGTAATTTAGATCTAAATTATTGAATATTTTTTTCTTTTTACATTGAAGAAAAAAATGATTAAAATTCGATCATTTTTTTGGGAAACTTAAGCACAATTTTCACAAAAATGAAATCACTCGCCAAAATTCAAAAATGAAGAGTTTCGTGGTGCGCCGGGTTACGGTGGATCTTAAGCATGGCTGTTTTGTATTAGGTCTCACCACGAAACTTGGAGTTTTTGATAGTTTACTTCCTATTATTTACTGTTTTAATTTTCGCTCGATTTTCACACATTTTCACTCATATTCACTCAATTTTTTGCATAAAAAATGATTCAATGGACATTGTTATGACGTATATGAGCAGCCGTTAATCTCTGCGCCTGTAAGCTTTTAGTAAGCTCCAATTTTTCTTATTCTGGCCTCAAATTATTTTTTTGATTTCCAGCTCAACGTTCACATTTTTCGCAAGCATCGCAGAGGAATGCAAACTTCTAGCTTCGGGCTCCAACGCTCGAGAATCCAGCAGGCCGCGGGGCTATCGGAGAAGATCACGGCAAGACATACCGCCAATTTCAGTAGGTAGTGTTCTTTTTTTACCCAACTACTTTTTTTCTATTTTCCAGCGTCTCCCACATTTCATCGATGGTCTTCAACAGAGAAATGGATGGCATCGTGAGAAATCGGCTCGACTCGGACATGTGATTTTGCTCGATGACACCAGGCGCCGCAATCCACAGTTGAAATCGATCGCGCTCCGCTATCTCCGCTACGATCACAGCGATCATAGAGCGTTGGCAAGGAAATCGCATCATCTCCTCCGACTTATATCAAAGAGGAAATTATGGATGATGAGCTCGACGAGGTGAAGGAAGAAGTGTGTGTTTCCGTTGGAGAAGCCGACTTGCCCACGCCAAAAATTGAACTGAACGTGGACCATCCGGAAAAGGACCTGATCATCAGCATTTCCGTGTATCTCGGCTACACCCGTACCCTTCAATACCACGAGATTGGTCTCGGACGTTTGATGAAGGTCAGGGATCGGCTCGAGCTCACCGGAGATCACACGCTTCGCGATCAGAGAAAACGCGTTCTCGTGCCCCATCGATTTCTCGTTTTCCGACGATTTTAGCGAATCTAGAAAGCCGTCGTTCAAGGATATGGCGAAAAATAAATGGCCGTCGTCGATGGTCTGCATTCTGACACGCTTTATATCGACTCGAACACCTGGCGACAAGTTTGTGGATCCGTCGATGTGAGCAAGGGTGCCGGCTAAAAGTTTTTCAGTGTTTTTTGAGCGAAAAGGAACAATTTTTTTCCCGCTTGAAAATTATTGATTTTCCGTTCTTCAGTAAAAATCCTGACTTTTGACGCCGCAAAATCGTGAAAAAACAAAAACTGAAAATTAAGGCACCGGATTTTCGGCCGTTGATAAAAAAACCGAATTTTTAGGTTTTTTCTTTTCAGAAATATATTATTTTTTGCTTGTTTCAACAAAAAAAACCCAAATTTACAGCACAATCCGAAGTTGGGCCAAAAAGTGACTACATCGGTCCGATGCACGTGCAGATGTCGGTGACGAGGATATGCGGGCGATCTCACTTGTCGGCTCGGTGCCATACGTCTACATTCATCAAGGCGTCTGCGAGCACCTCATCGTCTTCATTACTTGTGCCTGAGGTACGGAAATTCTGGAAAAATCGAAAATCGTTTTGATTTAAAAAAACGCAGATCTTTATGTGTTCTTTTTACTAAAGATTTACAAATTGTTTATGATAAAACCACTATAAAATAAGTTTTAATGATTTAATCACAATTTATATTTTCCGATTATCAATATTTTTTTTTTTCAAATAAAATACCCCGAAAAATATATATTTTCTATTTTTTCTATTTTTTGAGTACAGAGATGTATCCCCAAACGTTTCCACGCCGCATCGTCGAACGGAATTCAGAAGAATTGTGTGACACGTGCAAGGAGGCATCGGCGCAGTGGGTAGTAGCATTTAGAAATTCGGACTTTTTTGTGAAACCCCCGAATAATCTAGTTTCCGCATTATCGGAGTTCGAATTTTCGCACAAAAAATCCAAAGAGAATCTATTAAGGCAAAAATCTCAATTGATTCCAATTTATTCAGCTGGATGATAACACGACAATCTGCTTCACAACTCGCCAGGCTATCTGTTCGGCTCTTCGTGCTAAAAGGAGTTCTGTTTCGACGTGAACGGCAAAAAAGTACTGTGTCAATTTAAGGCCGTACCGTATTGCGAAAGGACATTGGCGACGGACGTTGCCAGTTCTTAGCTCGATCTTTAGAGAACGAATTTAAAAATCTGTCATTTTTTGTTGGTTTTTTTTAAATGTTTTTCCATTTGATTGTTTAATTACGATTTTTGGCCTGTAATTTGTTGAAATTTCAAATTTCTTCATTTTTTTAAATAAAATTTTTGTTTGCTAAAAAACTTATCAATAAACGGAATTCGAAGATGAGGCAAGTAGGGGGAAACGGATGAAGCGGGAAAATGATTATTTACAGAATAGAGCGCGCGCCAGAGGTTTCTCGGGGGAGCCCCGACGCGGGTTGCCGAGCTTGGCTCATCTGTCGGAAAATTAGGTTAAATGGGAGAGAGGTAACCTAGAAAATGAGAGAAATTCGGAAGAAGCTATTTTGATCAAATTGAATCCCAAATCGAAATGTTGAATTTGAAAAATAAATTTATTTTATTGATTTTTTGCAAAATCGATTCTATGATTATTGATTAAAAATCCCACTAGAATCAATAAATCTGGAAAAATCAAAAAAATCGATTTTTTATAATCATGAAATTCAATTTTTAAAGAATCCAAAAAAGTCGATATTTAAGAAATTGATAAAAAATCGATAAATCAATGGAGAGCTCGTCTCGTCGATTTGTGTCTTTGTGATTCCGGCTGCTTTTGAGTCTAGGTAACGTTGTTCCGTAAGTCTGGAAATTTTTTTGGGACGCAATGAGCACGCACAAAATGGACGGTGGCAGAAATTTAATAATTTTAAAAAATTTTCTGGATAAAAAAATCGATTTTTGCACTTCGCTTTTCTAGTGAAGAAAATTTAAAAAAAATAGCATTCAAAAGCTTGTTCAGGGTCTCGTCACGAAAAACTCACAAATGTTATCACGTTATGCGGAGCGTCGTCGAATTCCGGTGTGTTGCTATGGATCGTGTCGTTCCATGCTCAGCTTCATCGACTGACGTCGCCGTTTTCGCTAGTGGTGATCTGAGCGAGATTTATTGATTATGTCTTTAAAGACGCATGGCCTAGATAACACAACACTTCGCCCACGAACTTGATTGGTGGCCGAGTCTTCTAGGCCATGCTGCGGCTTTTAAAGGCACATAACATGATAATGACAAGATCGCCAACGGCCTAAAATGATGACCAATGCTAGACGGTTGAGGCATTACAATCAGCTGATCAGCGATGATAGGCCAGGAATATGACGAACTTTGCGTCGAAATAGAATCGATGTACTCTTGTCACGTCATTCCTGGAAATTATTGATTTTTTAGGAAAAAATCAATAATACAGTCAACAGTAACCCTCAACGAATCAATCTTGTAATCCGGTGAAATCATAGAGTAATTGCGTGAAAATGCGGCTTCGAACCTGAAATGATAAAAACATTCATCAATTATCGATTTTCTTGAAAGTTTTTATTTTGAAAGTTTTTACGCCGAAAATCGCGATTGATACATTAACTTGATAGATTTCCCCCCGTCGGAAAACCTATGAATCAATGAAAAAGTTAATATCTACATTTTTTCGAAGAATTGAACTAAAGTCGATTATCCAGCAGAATATCGATTTTACTAATCATTTGAAAAATTATCATTTAGACGATTCCTACGGAAGCCCAGAACAAATCAAAAATCGATAAAATTGACTATCGATATTATTCTAATTTTACTTTTTTCGATAAAAGTCGATATCGTTGATAATCGATTTTTTAGAGTTCTCCTCAAAAAATGGTAATAAAATATTTCTACGAACTCACACATTAACAGCCATTTGAGCATCACCAGGTGATTTTTTGCAGGTTCTTCGGCTCCGACAACCACTGATCCTTTCAGTGACTTGATTTCAACATTCACTCGTCTCCTGAAATGGAATTGATGAATTCTCTGATCTGGAAAAAAATACAATAATTGTTTAAAATTGATTTTTTTCAGATCATTTTTAAAATAACTAGTCTAAATCTATATTGAAGTCTAACTCAGCAAAATTACCACAGGCAAAGGATACGATTAGGCTTAGGCTAAGGCTTAGGCTTAACAGGCTTAAGCTTAGGCACACGCGAGATGAAAACAAAAGAGTTAGTGAAAACAAGAAAACTTTTATAAAAAAGAAAAAAAAAAAAAAAAAAGTGCAACACGTCGCCAAGCAATTCTAAATAGAACAGGTTCAAATACTATCTGTGACTCAAAAATCAGTTTAATATCGAATTTTTCCCACATGTCAATAATCCATTATCCATTCACCTTTGACTCGCTGGCACGCACCAAATCTATTTCTCGGTACCAGGGCCACTCTGAATATCGTTGAACTCCTCTACAAATTTCCAGTTAAATAATAGTAAAACTATTGGTGTTCGAATGGATTTAGCCCGAAGGAATACTTTCGATGTTTTGAAGTGCCACCGGCACAGTTGAAATATCTTCAAAAGTCGTGGATTCCTCTGATGAGGTGGAGGTGTTCGGAGGAGGTAGTGACGTCAGTGGAGAGGGTTTGGCTCGGGTTTCGGCCATGGTGGTGTCCATTGTGGTTTCCATAGTTTTTGTAGTTTCCTTGAAGTTCATTCTGAGGATGAAATATTTGTGCGAAGTTTTGCATTTGTTTTTTCCTGCAATATCTGAAGACTTCCGAACCAGCAAAACTCACTAGGTAGTGTTTTAACTATACGGTGCGTACAATCAAGTAAAAGTGTCATGCGAAAGCTGGCAAGGCTTTAAGAATCTGTAATTTGTTCCGGCGGAAGACCTCTGTTGAGTCTGGAAATTTTCATCTGAAAGTACTGAAATCTGCATTTCCTATGGATAACAGTTTTGTGTCTCTGGCGCCTACAGAAGTCGCACCACAATGGTGGAAGGGCGAAAACATCGCTTCGAAGCTGTTAACCATAGGAAATGCAGATTTCAGTACGTGAATTTTCGTCTCAGCGGGGATGAAAATTTACAGTCTCTGACAGAGGTCTCCCGGCGGAACAAATTACAGATTCTGGAAGCCTAAGATGCCAGCCTTGCTATCGCATGAACGATTTACTTTTACACGAGCACCGTAGAGTTAACACTCCCTAGTCAGATATGTGCTCTACACTTTTAAATTTTGAAATCAATTTCAACTTGAATATAAAATTAAGAGATTTTTGAATTTACTAGGCCACCTCGAAAATTTCCAGGCCACGGCAGGTTGGTAAGGTGAAGCTGCAGACCCCATAAACCTGTGATAAGTGAACGCTTGCAAATTTTTTAAAATCAAACATTTGTGAAGAATCTGAATATTATCAGAACAAAAAATAATTTCGACAAATAGTAATAAATTTTTTTATCAATATAATTTTTAACTAGTTCCCAAAAAACTCAAAAAAAAACTCACCGAGACAGTCGTAGTGCTCTCATCTGCCTCGTAGTTTTCCGGGTATTCGACAAAATATTTGACTCTTCCTCAGACATTTTCAGAATTGGGAATGGGGGGCTCTGACCTGTGCTCAATTAGCTTTCAATAACACTTCCATCCTGCTCAAAAAGTCCTTCCAGTGCACTTTGATCAAATGGGGTTTCTACCTACAGCTTCTGATGGGTCGCTTACTGGTTGGATGGTATGGGTTTTGGTCACCTCTGTCTAAAAATTGGCAATTTGGAAGAGAAAAACCGCCTCGGCCATTGGTGACGTCATACTTTTGCCACTTCTTCGACCAGCTATAACCCGCTTTTAGGAAGTTTTATTTTTGGTAAACCAAAGAGACCAATTTTAAAACTGTGTCTCCACGTTTACCGCCAACTTAAGGGCGTGTCCGTACAGGGTTTGACCGTTTTATCGGGCGTCTTAATAAATCATTTTCAAGTTTTCAGTTTCGTGGAAAATTAACATCGGAAATTGAGTCATCAGGTATGACGTCCGCTGCCGCGCGGCTTCCCATCACGTCACTCCATGCGCTCCCCCGACGTCCCTCTAAGACGTCACCACCTCTCACCTGGGTGTGTCATCTCCTTCTCAAAACTCGTCTATCAGTGACCTCGTCCACCCAGTCAATCGGAAGGGAGCTGAACGTAATCACCCCGCCCACAAGGGAGTGGTTGGCATCATTTCAGTTATTTTCAGCGCCGAGAGTTTTCTCAGTGGTCATCCTGATCCTCCATACTATCATCTTCGATTCTTGTGTGTGTTAAAGTTCTGAACATACCGCCGTCAAACGGAGTTATTGGCTCTAGGAGAAGACCGGACGTTTTCTGGTTGGGTTCACTCCTAGGGAGGTGTGGTTCGGCGAGAGATTTTTCGATCATTTCTGTACTTGTCTCGAGGTCTATCCGATATGAAAGTTATGACACATATTTTTGGTGGCCTGGGACTAGGCCTCCTGTCAGCCTAGAAATCTCAAACCTCGGCCTCCAGCCCTCACTAGCTGACCTAGATTTGGTAAATTACTAAACATCGGCAAGACCTCTTTTCGACTACTCCCTTACAAATTTAACAGTTTTTCATCACACAATTTTCCGATGCTTAACACTCATCATTTCTTCATTCGGAACAGCCAACCATATCATCATTATCAGGCATTACGGTGTCGTTGTGTCTTTTGCCAGCTGTTTGTCGAACACTTCTTCTGAATTTTCGTGTTGCGCGAAGGAAAAAAAGTTAAATTACATTTTGTCTAGGCCACCAGTTTTTGCATTTAACTTTGGCCTAGAAAATGAAATGAGAAGCTAGACCATGTGGGTTTATTGCGAGGAACGCGCAAGCTTACATATCCCACGAAAACTTTTATAAGCGTCTAGTAAAGTAGAAACCTCGGACCAAGTTTTGCACTGTGACCTAAACAATTTTGGTAAAATAGCAGCAAAATTTCCATGATGGCCTCAGGAAAACTAGGCCAATAAGGTTTCTTCCGGTACCTATCCGTTTTGTAAACCTAGGTCACCAGTTACTAGGACAAGAAAAAGCTAAAAACCAACATTTCAGATTGGTCTGCAAAAGGGCAAAATATAAGCCACTAGGAATGTTTGCATGGTGGTAAAATATCGTTGGACGTGAACCAGAAGTTTATCGGTCATCAACTTACGTGTCGTTGAAAATGCAATGAATAGATAAAACAAATGGTAACACTGTGCATCGCTGAAATATTGCAAAAATTAATTTATATTTTGGAATATCAGAATCGGAGAGTTCATTTTTTTGGGTCAAGATAAAAAGAGTGAAATGGAGAAAATTTATATGATATATCAGGTCAAAATGACCTTCGGAAATTGGGAAGGAGAATAATCCAAATTAATTCGCGTGGAACTGGTTAAGATGATCGAAGATTGGAGCGAAAATTTTGACAGAAATTGCAACAATACTAATGCAAAAAGTTGTATAATTCTTTCAGTTTTCAGAAAATCGATAGCAAAAGTCTTTTTTTTTAAATAATTCAACTGAAATATTTTCGCTGCGAGACCTAAGGTTACAAATTGGATTAAAAATTTTATGTGCCCATTAAGAGTTTTTCTGGAAACTGAAGAAGTCGAAAAATCTATAATACCCTACTTAAATTTAAAGGCGCACGAATAATTGAATTTCCAGAAAAATAAAAAAAAACACACAAAATTTGATACTCCAAGTTTAGAGATGCATGGGTAATCAATGTGAATGAGAATTTTGTTAAATTTTTGAACTGCAATTTCAGATATTATGAGAAAGCACAAAATTCGAATAATGCGTATTGCGCAACATATTTTGCGCTCAAAACGGCTATCTCGTAGCGAAAACTACACGTATTTCTTTAAATAACTACTGTAACGCTCTGTGTAGATTTACGCGCATCAAAAAGTATTAAGATCATACATTGACCGACAAAATGTTAAAATTAGGCAAAAAATAAACGAATAATGAATTTCGTAAATCGAGCACGTAAATCGACACAAGCGCAGTGGTCATCAAGAAAAATCACTGTACTACGCGTTACGAGATATGTTGACGCGCATAATATGCTGCGACGCATTCTCAGAATTTTGTGCGCCCGTAATAGACCATTTGTAAAATGCTTAAAAACTTCAGATTTTATTGAAAAAAATTTCTATTTGAGCAAAATTTTTCGAAAAACAAATCTCGGAAATATATTTTTCCATCGAAAAAGTCTCGTAAGGTGTGCTTGACATAATCTTGGTAATGGCATATTTTGTAAACAAGGTTACAACAACCCCTTCCTTCAGCCCACCCGCCCGGGAAGCCTGGGCATGGCGCAAGTGCTGATGTTTTGTCTGTTGTTGCTTATGTATATGCTTATTATTTACACATTTGTGTGTGTGTGAGTGACTACACTGCACACCTCTTGAAACGGATTATCCGGACGTGGTCGAGCAACGGAGGGACGCCGAATTATGCACAATGCTATGTATTGTGATATGAATACTTCATTTCAATAACTTTATATATGTTAGCACACGATTTTTGAAAATTGGGGTTGTGGAAGAGATTTTCACACTGGCCTAAAGTTTTTGAGTTTACTTTAATACTTCTAAATCACGTGGTGTCGGGCGGTCTGCTGCAATACTATTTGATCTACAAAAAATGCGGGCATTTTTTCCCAGAAAAAACGTCCGCACGCTCTAAACCATAAAAAATCGAGATCTGCGTCTCAACTCCCGTATTTTTTGAAGATCAAAGCGAAATGTTTCTGCACTCCACGTGCTAAATGAATATGAACGTTATAAAAATTATCTCTGGAAATTTGAACAGAATTGCTCCCCCGGGTGGAGCGCGTTTGCCGCTTAGTAGCTGAGAGACTTAGCTGCGCCGTGAAGGGAGGGAAAAGTAAGGAAGTTATCAAAACCAACAGACGCACTTATGAAAAGGAACACAAGAAAGAAAGTGTTCTTTTTTCGATTTTTGTGATTTAGTTCGTGTGTGATAAAAGTTCAAATGGCTCGGTAGGACAATAGGAAGGAAAGTGGAATTTTATATTTCATCTTTTGTTAAAATTTACTTTTGTAGGTGTATGATTAGGTAGTGTTAATAGAAATCGGGACTCGCGGCTTTCATTTTTTTGTGGCCGAGTATAAAAATCTTCCCGTCAACCATACGTGTTAAAGGTAATCAATAGGATATCATATTGGTAAACTTTAACAGAAATCCTAAACCTAGGTTTTCCGAACTATGGAGCTCTGAAGTAGGCCCCTTTGGGAAACATAGGCCACCAACCTGAGAAAGGTAAGGTGAGGGCAGGGTGCATAAAATACAACTTTTTCTCTGAAGTTTTTAATTAAGCGAACAAGCCGATATAAATTTTTCAGTCATGGCCTGACTTGACATTGGTGGGCGGATTTTTTCGAAAAAACTCTCACGATTTAGAACATGAACTTGGCAAAACTTCAAACAAATCCTAGAGATAGGTTTTGAATTATGAAGCTTTGAAACTTCTAGACAGGGGCGTTGAAAAAGCTACCCCTTCCACTGTCATAAACTTATAACAATTCACAATTCGGCAAACAAAAGTAGAGATTTCTTTCATATGTAGAATTAGCTCAATTTTTCAATCCATTGCACGGCTAGATTTGAACTCATAATTTGAAATTTTTCGGCCACGCAATAGAAAATTCTAGTTCATGGGAGTTGAAAGCTCGGACAGGAGCTAATTTTAAAAGCACAAGAGACAGGAAAACCAAAAATTTGTAAAGTCATAAAAATCAAGTTTTTTAGCTATGAGAAAAGGATTAGAATTTCAACACGGCCACCGATCGCCGGAGCGAAGATACAATCATTTTGGGCATAGACGTCGTTTGCGCATAATCTTTCTCACCAAAAAAAGATTGAAATCTTTTAATACGAAAAAAAGTTGGAAAAGAATTAGAAAAATGCTGAGGAGAAATTTTTTTTATGAAAGCTTAGGCTTACAATTTTAGGCTGCTATTTTTTCAGTGTTTTCCATGTGCAGAAAGGAAGAAACCGATCCCGACTTTCTATCACACACTGAGGGGAATTTCACCCCCCCCCCCCCCCTCAATTCCCGCTACTACTTTTACTGTACACTCTCACCGAAAAGATATTGTGTCATCACGCATCATGCCAAAAACGCAATCGTACAACCAAGGAGAAATAATTGATGAGAAAACGCAAGTGTTTCTTCATACACTACATAGTGTTCAACACCCCTGCATGATATGGCCGCGTGAAAACTCTTCCACGGCCAGGAGTAAAAGAAAGTTTTACGGAACAATCTAGCAAATTTTCATAACAATCGGTTGGGAAACTAGTTACAGGGGTTTGAATTTTCTAGGTGGGCCATGCGGAAAAAAACTAGGTTCGGCCACGTTTTGGTTAGGGAGGCGGTGTCTTCAAAATAAATCTATATACACCTCGCACCTAATGATCCGCCCATGAATCTTCATACAGGGGGAAACAATGAGGTATAATCTTAGGTGGCCGAACTTTTGGTTCGTGAAGAAATCTCGGCCAAGACCGCGAAAAACGTATTCTTTTTTTGAATCGTTAATTGAAAAACTGAAAACAAGAAGTTTCTAGGCCATGTTGCTTAACCTTGGGGCAGTAAATATTTTTCCTAAGCCATTAAATTACTACACTGAAAAGGCCCTAGGCGCCCACGGCTTCAAAACATAGGCCACCAAAAGCTGAAAGAGGGTTAGGACCGGAGCCTGCTATTATGAAGCAAAGTGTTTGTGGAATAAAAAGTTTCAGAATTTCCACCAGTTTTTACAAACTATTTTTTCTCTGGAAATTATAAACCTGAAATTTCGAAAGCGGACGAGATCGTCAAAGAAAAATAAGACGAGCTTGCAATTCGGAGGGCCAAAAAATGAGAAGAATTTGAGAACAAGAAGAGGGTATGACGTTGACCTATACGCGTATTGTCTTTTTTGTTTTCCTTCTTCAGAATGTGAAAGAGAAACTGTCATAGCTAGTCGTAGTTCTTCGATCACCTAATCACGTTATTGCGCCCTTCGAGCACAGTTTTTTTTAGGAAATGTGTGAAAAATACACATTCTTTGCGCTAGGAAAAATTGTGGGAAAATTGAGGTTATTGAGGTCCCTTGCCACGACACCGTGGCCTAGGATACCGCCGTGCTCTTGAAATCTCGCTTGTAGCCTAGAAAGTTCCCATGGTGGCCTGGAGAAGTTTAGCGGGGCCTAAGACTTTTAATTGTGAGTGAGTTTTTTTGGCCTAAAATGCTATACGTGGTTAAAATTCCTCATTGTTGAAATTTTTAGCGCGGCTTAGGATTTTCTATAATGGCACTGGATTCTCGCCGTTACCTAGAATTCCGTAATGTGGCCTGAAACTGGAGTTTAAGGGTGAAAAGTTTAAGTATTTTCAATCGTTGCCTTGAGATTTTTTACAAGAATTCCTCATTGTGGCATTTTCTATTCTGGCCTAGAAGTTTGCATCGTGGCCTAGTAGAAATTTGCAGAGCTTGGTTTTGAAATTCGGTTTGTTACCTAGGGTGCTATATCGTAAATTCTTCCATCATAACGTATTTCACATTTTGACCTGAAAATTCTTTGCGTGGTCTAAGATTTCTCATTCTAGGATATTCTCGAAGTTAAAGACACTATTGTGAGAAAAAGTTCGTCATGGCCTAGAAATTGCTCCCGTGACCTAGGAAGTTTCAAATTTTTTCAAAAAAATTTCACCAGAAATTCATCAAAATTTTCAATTACGGAAAAAGAATCATTAATGATTAACCACTGCAACTTTTTTCGAACTAAGGACGAGGCAAAAAGATTAGTACACTAGGCCATGGCCGAGTTCCCGACAAATTTCAGCGGCCCACACGTTTATTTTGCTTTGTTTCTTGGTTTCTCTCGTTTTTCACCGATTTTTTCCGCATTTTTTCCTATCAAAACTAATAAATAAATTTTGGAGATGCTAAAACAATCAAATAAAATTGTGAGTTCAGTCGTGCTGGTCAAGTAGCGGTAAAAGTGGTCAATGTAATATGGATTACGGCAAAAAAAAACCCAAACTTTTTCCCTAACATGATACATATGCTGTTTAGAAACGGGAAAAATCGTGTGAAAACAAGAAAACAAAGCAAGAACTGTCGTAATAATGCGGTGTATTGTGTGCAGACACCGATTTTTCGCATTTTTTCTCGGCCCTCGAATTCGTAAAAAGTAGCAGTGTTAACGGCGGTAAGAGCTATACCTACAAAAGGTGGCCACAAAAAAAATAGAAGAAAGGATCTAAAAAGAGCAGGGAAGAGTTTCTCAATTGGCCTCGTTATAGAAAATAAATACAATAAATATGTTTTTTGGAGAATTAAAAAAACAAAAAAGTTCAAGAAAAATTTAGAATATTTTTTCAGTTTTTTTCCTGATATTCATTAAAATAGAATAAATGGAAGTTCCACAAAAAGCAGGAAGGTGAGCTAAATACTTTAATACACCTCCTCCTCTCAATTCTTCAGAAAAAAGAATAGGCTTCTCCTCCTCCCACCTCCCAGACACTTATCAACACTTTACCCCATTCCTCCCGGCCCCCGGCTTTTTCAGATTTTTCAACCTTGAAAATGACGAACATTTCAGATAAATGTTTCTGAGTGTTATCTGAAATCAGGGTGTTGAAGCAGCCCCAACCGCGTGTAGCGTGGCCTAGAAATCCGAAAAGTCTTTTTGATCTTCCGCTTTCTCCAACTAGCAAGTTAGGTCTTAAGTCAAATGGACTCTCCATGACCAAGTTATGACGATTTGTAGTTTCTAGGCCATGGAGTGCTCTCCGAGGGGCTGAGACTTTGACCCCCTGACGCCGGGATTTGTAGGACTTTTCACCTGTTTATGCTACTGTAAGCGAACTATATACGTTCTTCACGCCAAGATATCCGTCAAATTGTGACCACCGTTTCAGCACTTTAAAATTTCTACTTGCATTCGCCACGCTGTCGCCATAATGGAATATTTTTCTCACGAGGAATAGCATAAATTAAAAAAAAAACAGTCTTCAACTGGCCGATATTTGGAAAACAAATCCTAACGAAAATGTTGCAGAATTATTAAAAGCTTAATTAAAACAAACCACAAAAGTTACCTAAAATGAAATAAAGAAATAGGCGTACAGAATTATAAAACCTATAAGCATGGGTGGGTCACAGGTAAAGATTATGGAAAGTTTTTGAGGGAACGTAGGAAGATATTACTGTAAAGTTATGGGGGAGAAGCGAGCGGCTGAAATCAAAATGGACTCGGTTGAACGCGTCGATTTGAATCACGGAGAATCGTTTGTAGGGCTTCCAGATAAAAAATGTTCTGCCTGCATTGTTGGGCCAAAACACATGAATCATTCAAAAACAAATTGGCATAAGAAAATACATACTTCTCCAAAAAAAATCAAAAAATAGGCGATAGGTTTTTAGATACAGTATAATTTGAGCAGTTAAACTATTCACCCCCTACAACTGGCGGGCCCGCAGGGCCTTCTAGTCAGGCAAAAAATATACGGCCCACACTCACAGCAATAAGAAAAGTTAGGGGATAGTAGAGACTTTTACTCAAAAGGAAGGCCGCATTACACAAATGTTTAAACATTAACCTCAAAGCGGGAAATTTTTTTTAATGCGTACTGAAGAAATCGACGTAATGAAACTCAATTCCTACCACCCCGTAAACCTCCTTCACGTCCAAAGTAGTCCATAGTGACATGAATCCTTCCGACCAACGTAAAGATTGGAGATGACGAAATTTAAGATGTACCAGTATACTGGTACATACAATTTCTACGTCACAACATCTTGACAGTCTTTTTCCCTCAAAGAGATGAGCCCCTTGTGAGATACAAACGCTGCGTCCTATCGTGGGTTCAGTTGTGGTGAAAAATTGTAAAAACTGTAAGTACCAACTATGCTGATATGCCAACTACCAACCAGCATAATTGGTGCCAAGAGACTTTTGCCACCTCGAATCTGTATGACGTTGGTCGGAAGGCCTTTTGTCACTATTGATTAGTGGGAGGCTTACGGGCTTGAAACAATCGTTTATTAAAAGACGTATCTTATTCAGTACGCAATATTGGTTCCCAGCAGTCATTTTTTCCGCTTACGTAGATCTTTAAAAAATGCTGGAGAAGATATGCAGTGTTCTCAACTAATTTCGCAGAGTTAAGAACGTGCTGACGTCACTTAATTTTTTTGAGCAAAAAATTCCGGCATTTTTTGTAGTTCATTCATATCCGTAACCCTTGGACAGCCTGGCACCACGTGTAAGAGATGTACACGATGCCTTGCCTCTATGTTTGCCCGGGAGTGTGGGAAAAGTTGTAAGCTGTAGAAAAATGGACAACAAGCATGTTGTCAGTTATCGCAGCATTTTATAAGTCAATGACAAGTACAACAGAGAGCTTAACTGAAAAGTTTGAATGGAAAACTTTCAAAAAACAGCGAAGGTTCTTTGATGGATGCAAGGGCAGAAAGTGACTAATGCATGTGTTTGAACTTAAAACAAATTGGCTAGTCTTTGACTGAAACTACCTTTTATAAAAATGAAGAAAATGAACCATTACGAAAATGTTAAACTGAAAGTTGGTGTGTTTTTATTGTCGTTCTGTAATTAAATTCCTTGAATGATCGCTCTTCTGCAAAGAACAACCACAAAAAATAATTCGATATACTCAAGTATCGACGACTTTGATTGGAATGCAAACATATAACAAATTAAAATAAAAATTCTACGGTCATTATATTTTAGGAAAATTATTGGAAATTTTTTAGGCTTCTGAAGTGTCAAAAACTTTCAGAACTAGTAAACACGCAACATTTTATATGTAATAAAACACTCAGCGAGTTTAAACTTTGCAAGACATTTTGGGACATAATTTTGGCCTTTTAAGAACAATTAATTGGAAAATAAAATAGTTAGAATGATCGTTCTTCAAACAACCTGACATAACAACAACACACCTACTCTGTTATAATAAGAAAATGTAACTACTCATCCGAGTTGTCAACCTGCAAGACCGCATAAGTTTATACCACTCGAACAAAAAACAGTCTTCGTTCTCTTTCTTGAAAAGAGACATAATTGAAATGAACTAATCACCGCTGCCCGGGATGGAAAAAAGAAAAGAAAGTCCTATCATCCTTTGACCTTGTTATTTTTGCAAATCATGTCTGACTAATACACTTTGTGTTCGATACATATTTCACTGAATCAGGCGTGGGCGACAACCAATTTTTACGGCAAATCGGCACATTGCTGGAAAATTTCCGGCCTTGCAAATCGGCAACAAAAATGTTTGAAAATCGGAGAGTAAAAAGGTGGAAGTCACCAGCAGTGAAGTACCTACTTTATTTCACATGAAATTAAAGTATACACCATCTCTCTTTTTTTTCCTTATTTAACAGTCTTTGGTCTGTGTTCTGACTGTTGAGAGATCAGGGATCATGGACGAGTTGTTTTTGGGAAAACAAATTCTTTTTGGACTCCTTTAGTTTAGTAAACGAAAAATTTAAATTTATAAGCATATAAATATTTTTGTGGGAATTTGAAAAAAAAAGAAATTAAAGAAGAAACAAAACTAGTGTTCAACATGTATAACTGGGAGAAAGAAAGAAGTGCGCTTCCAATTTTCAGAACTTTTGCAAAATTGTAGAAAGTAGTTCATGCTTCAGATCAAAGTTGTAGGAAAAAATGTGGCCATCCGAAAGAGAAAATTCTGCCACGACCAAAACTCAGCACTAGACTGAAATTTCAGTAGTAGCTGACAAAACCATCCAAAAGATATTGTAGGTTACAATATCTACCGTGAAAATTAGAAAACTCGAATCAGATATCCGTGGGCAAAGCGAAAAAAAAATTAGAGTTTTCTAGGCCATTCGAAAAACTCGTCCACGTGTGCATGAACTGTCAAGTCGCCAACGTAAAAGGTGTGAAACCCTTGAGAGCACTGAGAAAGAAATGAGATAAAGTAGCAGGTGAGACCTCCTGTCTCTGAGAAGCAACGTTCGAAATTCTTTTCCCTACATTCCATCTATTATCATTATTATTATTATTATTAGGACGGTATGGAGCCAGGAACTGGTTGTTTATACTGACCACTGCCTCTTCCCGATTAGGATTATGTGATTCGGATTTCGGGAATTGAGAATGGCAGATGGTTTATGTAATTTAATCATATTCCTCAAAAAGTTAAGAAACAAAAGAAGGAAGATATAGATCGCTGAATCAGTGAGGAGCAATAACATAGCATATATGGAATTGGTAAGACTGGTTTACAGTTACAAGGGAAAAAAATTTGAAAGTATTCGTCATCTTATCTAGGTAGTTGAGACACTTGATTACTCAGTTGAATGAACAAATGGATGAATACAAGTTCGTATGCTGAAAGCATCTCTAATAACATAGTATTGGTTTTAAAGGTGGAGTACGGTCGTGGTTTTAACCTAACTGACAAAACAGTCCCAATATACCGTAACTGTTAAAGATTTATATAAATTTATTCTGGCAAATTGTTTATAATTTGTAAAAAAGTTTTTTTTTTAATTTAAAAATTTATTAATTTCCAAAAAAATAGTTGATTCAAAACTAAAAACCCAAATTTTCTGAAACTTTACCAGTTTTACTTATTGTCTTAACAATAATATACACATATTAACGAAATACTCACCGTTCAAAATTTGACTTCTTGAAATCTCCAGTTTTAACGGCAATTAGAGAATTTGTTCAAAATTCCAATCTCACACCGAACGTTTTTCTTCGTTTTTCATTTTAAAACAGTTCTATCCAGTTTAAAAATTTACCAAATAAAAATGTGTCTATACCTCTCACCACCAATCCCGTGCATGTGTTCATGTTTACCTTGAAAAGTGTGTATTACTATATAATACAGAACAAATATCAAATGGCCACTCTCCTCCAGCAGAAGGAATGCTTAGGTGTACGAACACTGCAACACTTCCTATTACTCTTACTAGTTTTGCGCAATTTTCTGGTCCTTTTATGTAATTTTTTGTCTGGAACAGGAAGTTTTGTGTTGTTTGGAAAATTAATGTTCTACGTGAGATTTTTAAGTGATTTTTTGAATGGAATTTCAATTCATTATTTCATTGCATTTGTCTTTTTTTCTCACCGAAATCCACTTTTTTTATAGAAACAATTTTTTTTTCTACATTTTTTCCGATTTTTGTCATTCAATTTTTCAACTTCTCCATTTTTTCTACAAAACACCGACAACTACAAAATACCTAAAAATTGCAAATTAAAACAAATTTAAACATTTTTGCCGCAAAAAGTTGTTTTTTTTTACAGAACATCTAAAACTCCCTTAAAAATATGCTAAGTCATTTTTCTGAGAAGCACTTAATTTTTCGATAATATTATTTTTGCTATATTAAATCCAGAGAAATTAGAAAAAAAGAACGGTTTTCTACAGTACCTACCCTCCCTCTCCCTCTTAAAATCATTCCTACAGTGTTCTTACAGTAGTCTTACCTGCACCACTCCTACACTGCTCTTACAGTGATCCGATAATACTTTTATATAACCACACACTCCATACCTATACCTTACACTACAGTACCCCCGCCGTACCCGAGGCCCCCCCCCCCCCAGTACCCTTGCCACTTCAGTATCCTACATTATCTACAGTTCTCCTACACTACCTCTACAGTACTCCTACAGTACCATTACCAACGAGAAATTTGAATAGAAGTGAAATTATGAACATTTTTTCCTGTATACCAATTTTTAAAGTTTTAGTTTTGTAGTTGTTTTTGACAACGTAATCAATTTCAAAGTATTTTTCTTTAAACAATCGTACTTTTTGCGTACCGGTGGTTCTTGCACGGGGATTTTGGAATAAAAGTGCCCTCCGAAAAAAGCGAGTGCGGAATTAAAAGCACAAAAACCGGATAGAATGAGGAGGTGCGAACGATGGAATGAAAAAAGAAGCAGAAATTAGATTTGGTTCAGAGAATTCTGTTTCTTTTATTTGTCGAGATTTTGGTTTTGGAGTCTTGGCAAAATGTTTTATTTTTGTCCAAGAGTCCTAACGTTTTTTTCCACCAAAACTCCCAATTTCAAAGTTTGGAAATTTGATTCATCGATCTGCCAAAACTTCCGATTTAGAGAAATTAAATGTTCAGTTTCCCGTAACAGGGTTTCGTATCAAAACGAGTGTGAACCGCCTACCTATGTTTTTTAAAAATGATCATACTCTAATTTCCCTTCAAGCACTTTTTTTTTTGAATGACTATTTGAATATCCCAGAAAATTTTAAAAACGTCATGAGTTTTTTGAAAATTCAATTTTGCGTGTTCCTGTAAAAAACCATAGAAACTGTTGACCTATAACCTGCCCGACGTTCTTCCTGTCTGTTTATACCCCATCCGCTCTGCACTCCAGAGACCCCTCGTCCTAACTACACTGATTATTAAACTGTTACCCCGCCCCCCCCCGTTTACCCCTCATTTGTTTTTTATTCGGTAGTGCATCCCTTCCGTGTAACCTGACACTTTATTCAAGAATCCCGCATTTAGGAGGATCAGCAATTTTTCTGTTACTTAATTTTCCACACGGTAGGAATCGGAGACAAAAAGAAAACGTCATAGTTAAAAAATTTATGCGTTTAATTTTCAGTTGCTGAAAACTCAATTTTGTGGAACCGTGTTTTTCGATCTTTGTAAAACTGAATTTTTTTGAGGAAAATTTGGATTTTTGCTGGAAAGTCAATTTTTGTGAGAAATGGCGGGAAATTTAAATTTACTGAGAGAAATTTTAGCGGGAAATTAAATTTTTTGTTTGATAGTGAGAAAAATTCAATTATTTTTGTAATTTTTCATAATATCTCAAACTCAAAAAAGTCTGAAATTAACTCGAAAATATTGTCATTTGATATTTTGGCAATTCAAAAATTGCTTAAAGTAAATAACGGAACTCGTTTTTTTTCAAAAAACGAAAGGTATTAGTAACATTTCCGGTAACCAAGGTTACTCTTTCCCCATCAATCTCCCATAAGCATGCCAGAAACAAAAGAGTGAGAGAGAGAGATGCGTGTATGATTATTTGACAGTGCGCAACTGACACACATAAAACAGCTTACATCTTCTCTTTTTATTTCAACTGATTTTTTTACCTCCTTGTGTTCTCCGAGTCTCTCTGATTTATTCAGTTTCTCGATTTTCTTCCAAATTCATTCCCTTATATATTTTAATCTATGCGTAAAGTGGAGGAAGATTTCTTCTACGAATTTTGATCTTTTGCAAATTTCTCGGGTTTTTCAAATTATGGATTTTGAAAAAAAAAATTACTGAAATTTATTTTTTTCATGTCACAAAATGACTGTCTACCCTGAATTTTTCTATGGAATATAAAAAAAATTCTGAATTTTTTTTACTTGTTGATGTGTAAAACAAAAAATTAGAAAAATCAGATTTATCTGACGATTTTTTGAACTTTTTTTTAAAATCAAAATTAACTTCAAACAAGATTTTTTTCGGAATTTTGAAAAAAAATGTTGTTTTTTTGAGATTTTAGTACAACATTTTCGTAAAATCGAATTCATTTTTAATTTTTATTGTGCAAATGTTCTGACTGATTAACTATGAGAAAAATTTAAACAGTGTGAAGTTTGAACCCCCCCCCCCCCCCCCCCATTATTTGGACGGAGATACGAAATGTGAATTCTCAGAGAAGGAGGTGAACACTCTGATTGATGTGCATATTGCTCATTATCCATATTAGTTTGGGGCATATCGCACAGCGAGCATGACATGTACTTTTACCCATTTGCGTAGGCTCCGCCATTTCACGATTTTTTTTTTCCAATTTTTGAACTAGTACAAAAATTTCTGAAATTAATTTCTGCAATCTCACATTCCATTGTATTTGTTGCTTACTTCTATTGTTCCACAAAAGAAATTTTCGAATTTTCGTAATGTGTCTTTCAAATATACCATATCCACGCACATATGTCCCTTTTCCTGAATACTAATTTGGTGTCCAAGAGGAAATTTGTTTTGTCGAGATTACTCAGTTCCATTACGGAATATTTTAGTCTCTGAGAAAAATTCACTTCCTAAGTGTATAAGACTAAGTAAGTAAAACGATACTACAGTGTCAAGAATGGTTTGTTTTTTGTTACAGTCTTTACTATGTAGCTTTTGTTTTGTGTAGTTTTCCAACTTTTTTTTTGCCAAAATGAAGGCTGAGGATAAAAAAAAGTCAAAACACAGATTGGTTGCTGAGGCGGTATTATTGGTTTACTGTAGCATTACGGGGTTACTCTAGTTTGGCCCATGTTTGGTGTCGTTAGTAGTAACAACATTTCGCTCATTTGTTTTTTGATTTGGTAACTTCTGGTGACTAAACTTTTAATGTACCTAAATCTTCTGTAGCATTATTGATTTGTTGTTTTCTTCTTTTTAAGTTAAACATGCTCACATTAAATTGAAATTGAAATGGGTTGAAAATATTATTATCAACTTGAATACCAAAAATTTTGGACGGTATTTCAACAAAATTGATTTCAAGCCTCTTCGACCTTCGACACAACAAACGAATGCTAACTTTCCCAGGATTACCCAAAATAGTTCAACGGAATCCCGTTTTATCAATTTTTAGCACATACTTCTTCATAATCATGATTGTAATGATCGATCCGGTCTTCTATTATTAGATGAGAGAAGGCAAGAATATACATATGTGTCTTTTATATTAAATTAATTATATTTCGACACATTCTGCGCATATCACTACTGTACTAGAATTACATTTTGAGTAAAATGTAACCAGAAGAAACAGTTGTTTGCATTTATTGTAATAAACAGAATAGAACATGATGTTAGGAAAGTTATTAAAACTTGCAAAGTGACACAATTCATACCGATTTCTCTGCAATAGCTACTTAGTTCACTTAGTAGGCAGAGTTTTGATACTGATACGGATTCTTAACGGATTTTTAATTTAAATCACTATTGCTTTAATAACCTTTTAAGATTTTTTTGTTTCAGCGTGCAATTGTACTATTTTTTATTCTCTTTCCCCTAGAATTTTAATAAATAGAAAAATTTTGAATTATTTTACGTTATAATTCAATAGTAAAGAATCACACATCAAGCTGCCCCTATTCAGTTTCACATACTTTGCCTGATAAACATGACTCCATAGTAAAATGGACACTTTCATCTTATACAGACACCCGCCCCCCCTTGCTTCCCGATTAAATCCCAATAGTGTGGCAGCATTGTGTTTCATTGAATTTATTATCATTTGTCATACAGTACATGAAATTACAAAACAGGAGAATTCCTAGGTTAAACTTTTATACAATGAAGAAAAGTCTTCCCTAGAATCAATATTAAATTATCAAATGACTACGGTATTTACGTTTTTCAACGACGGTATTAGTTTTTATACTTACTAGTTATTAGTAGTTAGAACATTACATTTTTAAATGCAAGGTGATGCTGTCAAAATTTTTTTAGGGTAGACGAGAAATTGTCATAGTTTCCAGCACCATCACTGACAAGTCGGCCAAATTTCAAACTTTAATTTTGGAACGTCAGTTGGGCGGCCATAACTCTTTTTTTGAGACGTTTTCGGAAGAAGTTGAAATTTGGTATTTTCAGCATAGCGTTGTATCTTATTTAAAATGAGTATTCACTCCTTTTACCTGCTAGTCGGCAGCCTCGTTTTCTCCTATTTTTCACTAATGAGCACACACCACTATCATCAGTATTTTCACCACCTGTTTTCTAATAATAAACATTCCCCTCACTTTGTTTCCATATCGATGCATTTTATAGAAAATGTTCCCCCTTTCTTTCCAATTAGATTCACCCTCTGATTGCTCTTTCTTGGAGGGAATGTTCCACAATTCCCCATCATCTTATTACATATTTATGCAGATTTTATAGCATTTTAGTGCGCTAGATTTTTCATGGGATATTGCTATGCAATCACGCTCTAACTGGATAAAATTCTCAGTTTATATAATGTTAAACCCTACTGTGTGTAAAATTTACAAACATAGTTGAATACATTGAATAAGTATGAACATTTTTCGAGGGATCTATAGAAAATTGCCGGCTGTTCCTAAATAGGGCCCTTTCACTGGTCACCAAGTTCCTGTTCATGCAATTCAAAAGAAATGTTCAGCCCCTCAATAGTCGCCCGCACCACAAAATTGAAAAGCGATCACATAGTTTACTAGTCGAACGTTTGAATTGAACATATTTGGAGTATTTTAAAGAAATTTCAAGTCCACCAAAACATATGCCAAGGGCCACAAAAATTTCAATTTTCCGCCAATTTTTTTCTCACGAAAGTTGAATTTTCTCGAATTTCCGATAATATTCGATTTATTTGAAAGTTATTGAAGTTTATATTTTCTAAAACCACTTCCACAATAACAAATATTAATAGATATAATCCAAAATTTGAAATTCCCATGCAACACCTCAAAAAGTGGCTCGCTTAACTGAGTGCTGTCGCGGAGCACTACCCTTGCATTCTTTTCCCAACGGAGTCATGAACATACGAGCATTAAATGAGTAGACGACATGTGTATACATAGGACCCCCCACCACATGTTCCTTTTATGAGTAGACATGTCATACACACAATGTCTCTCCTTTCCGATTGGAAAATTAAAATCATATAGGAGCGGGGGGGGGGGGGTCTTGACATTTCAATTATTACCCCCCCCCCCCCCCCACATCCGTTACGTTGCATTTTGGTAGGCTTGGGGCCGAATAAGTCTCCCATGCAGGCGTCAAAACGTCTGCGGACCTACGCCTGCACGCCGATCGCGACAGCTGTACAGGAACCCGAAAAGTGGAACGCGGCTAAAGAACCATTCGCACTATGCGGTGTAAACACAAGGTTTTGATTTGTAGTCATAGTGCGTATATGATGCGGGACGCTGACAGGTAGGAGGCAAGCGTTCAACCGCGAATGCACACCATGGAAGCGCTAGAGCCTAGTTTTAGATGAGTTTCAGCATTTTTGATCTACAAGATTTTGAAAGTTTTACAAAAAGACCAAGATTTTTTGTAATTTATGAAGAGATTTTTCTACATTTCATAAACCAGCAGAGTTGTTTTTTTGGTAATTTATCATTAGCGCGTTCGCGTCATGAAAACAAAATGGCGGCCGAACTTTGACAGATGGCTGAATTTTTCGAATCGAACAAAAGTCCGTAGCTATAAAGCACAGGCCTACCTTGGTTTTTATTTGCTTTTAAATGATATAGTTTTCTAAAAAAAAGTCTATGGCCGAATTTTTAAATTATGAATAGGGGCTATTTCAAAAAAAATTTGAGGCCAACCTACTCTACTCAATTATAACTTGCCATGGCAGAACTTTTGAACAACTATTACAACGTTTTCAAAAAATTGCAAGTTAATTTTTTCGAATAAAGGTTAAATGTAGCCTAGTTTCTCAAAACAATAAGTGAATAAATATCGATGACCGAAGTTTATATTTGATAAAATAGTATTTGACCTAGAACTTTTAACTATTCTTCCAATGTCTGAAGTCTGGCTTCTGAGAAAAAGTTCGTGGCCTAAGTGTACCACGATGGTCTAGTTATCTCGATAGCCATAGCCTAGTTTTCTCAAAAAAATCTGGTGGGTTCCTGTATGTAGGCTTGTAGGTATTTAATTCTTATCTTCCAGGTATCTATTTCTACTTGTAACCAGGAGCAATAGTTTTGAATTCCCTCTCCCTATTCACGCTTCTCCCCTCACACTCGTTTTTGGTATTCTAATGTTCTCACGAAACTCCTCTTCCCAATCTACCCCCATTTCTTTTCCTCTTGGAGACCTGTCTCTCTCTCTTTGTATTGCTCTTTTACGTCTTCGAGTAGGCTTTTCCTTAAGGAACTTGTGTGTGTCTTGAATCATCATCGCGTTTACGCTCTCGTTCCAATTCCCTGTTGCTATTTTCTTGGAGACATTTGGAAAGTTTCAAAATTCCTACGTACACCTGCGAGGCCTCAAAATCTGGTTGTATATGGCATGACATTGAATTTCTAGTGCACACAATAGAATTTTCCGGGAAATTCAAATTTCGCGATCTGATAATGACTGAGGAAAGACTTTGGCGGAAATTCAAATTTTAAAAAAGTAGGCGGGAAATTCGAATTTCGAATTTTCTAACCTTTTTGGCCTTGGTTTCAAATGTTCTGAAAAATAATTTTGGAGCGAAATTCATATTTTCTCAGAAATATCTCAGAAAATTTGAAGTTTCTCCCACTAATATTCTTCTCAAAAAACAGTTACGTGACCTATTTATGTCCTATTTATTGGTCCATTTATTACGTGGCCTAGCGAAAAACATTTTTTCCCCTGCGATCATTTGAGATGGCGTAGAAAACGCAGATCCGTTAGGCCATCAGGTTTACGGGTTATAGTACAGCCTCTTGCAGGGGACAGGTTCAGAAAAACTACAAATTTAGTTAATTCCCTACCTACTCTTGCAAATCAATAACTAACCCAACTGTGTTTCAATCCGGGGAAATTTATTCTTAGAAAAAGTATATCTCCGCAAGTACATATCCCTCCTTCAAAATAATAATAATGGGAGGCTTCTGCTTCTCTTTTTTTAGACCAAAAACTTGTTGCACAGTGCCCTAATATGTACGGTCGTTGAGTTTTGTTGTTCAATAATATGTTGACCGTAATTCGCGCATCTGAAGAGGGGAGGTGTAAATGCTGTGTCTAAATGTTGCTGTCACCTCCAAGTGGTACAGGTGGCCTAATTTGGGAAAACTCTTCCACGACTATATTTCTCAAAAAATTACTCATAAAATTTGATTTTCTCACATATTTCTCAGAAATATTTGAATTCCCAAAATTGTTTAAAAAAATAGAATATCTTGTCAAAATTTTTATCAGATTTGAGTTCCACTAAAATTTTGCCGAGCGATTTTGTTTTCCAACTTAAAAGAGTTTTTTTTTAATTTGACAGTGAAAAGTTATCTCGGTCAGTATGCTTATACATTACAGGTGGCCTAGGTCGCATTATACAAGCCACAAATCTCCCAAAGGGGTATTGCCACACCTAATTGACACCTCCCCGGGGACCTTTGAGCACTAAGTATGGACACCCACCCCTCACCTATCAGCTTAATAGCTGCCTTTGACCGCTAAGGAGCATACCAGCCATATGTTTACTTAATTCTCTCACTCTCTCTCTCGGCTTCTAAATTGAATCTCCCCCAGTCACGCCTCTCGTTACGTGAGGAGTGTTCAACATGTTCCATTCCCTTCTCCGATAATCCGTGTTTTTGGTAGGCAGGAGCGTGTACTAGTAGAGGACATTTGTCGCTTCTTGGCCTTTCGCCTCCATTTTCCTTAATTTGTGACTTAGAAAATCGTAGAAAAAAGCATTAGTTTGTAGGACAACTTTTTATACCTCTGAAAAAAATGAAACTCGGCCACCGACTTTGTCTGTCACTTTTGTGTAGATATGATCACATGCTAAACTGTCGAACCGATGAGGTCAGGGTGGCTGAGTTTGCACTTTTGCGTGTTCTATACCATTTACAGAAGCTAGTCCCCCCGTCATTCTTCTTCCAGCAAAATGTTTTTTTTTGCCTCAATAGCGGTGTCTCATCAACAGCACAGCAGCCAGTTCATATTATTTGTTTTTTGTTTCGTCTTTCGTCTTTTCGGAAACGCTCTATTCTATGACAAGGTGACGTCATTGGACTCGTGGCCTAGAAAGTTTGGCAAACTCTTCCACCATTCGATTACAGGAGCCTCAAAGCCCCACATGGCTAAATCTTGACATTAGAAACATCCATTTTGAAATTTTTCGAAATTGGTGCAACCTAGCGACCTCTAGAACTTCTGACCTAGAAGAAAAAAAACCTCAAAATGTGGACTAGAAACTTTTAAAAACTCTTCCATCGATTTTGTTTTGTGGCGGCGGACGTTTTCCAGTTTGGCTTTTCACATAAAAACCAAAAAAAAACAAGACGTAAAGCTGTGAAAATGATTAGTCACAAAAAGAAGAAAAAAGTGTCGTTACTGCAATTTCATAGATTCCTTCTTGGCTTCTCACGACACGAGGGGGGTAGGGTCTAATTGGCACCCCCCCCCCTACTGAGGTGAGAGAGCAAGCTTGAGACTCACCCGTCGCTCTTGTTTTATGCATTTTTGGCACAAAGTGAAGTGGGCGAAAATTGTAGTAGCTGTGTGTGTGATGTGTGTATGAGCATTTCGATTTTTAAAATAGTTTTTTAATGTACCGCAGGCCACGTGGGTTAAAGTTTTTTTTCATAAAAATAGGATTTGTTTTCTTGCAGATAAGTTTTTCGAATTTTGAAATGAAAAGGATAACTGGGAACTCGGAGAAAAATTATGTTTTAATTTCCAACTAGGCCACGTACCAATGACGATGAGCAGTCGTTCTAGATCACAAGGTCATCTAAACTTTTAGGAAATTTAAAAAGTTGGTGATTACTAGAATTTCTAAGCCACGCCGCATACACCGGCGCGTAGGCGTTTTTACACTTTCTAGACTACTAAGATTTTCCTAGGCCACGTCCAAATCAGGGCTGTTGCAAAAAAAAATTTTCGACCAAAAAACAAAAAACAAAAAATTTTTTGGTGATCTAACTTAAGAATAAAAAACAAAACACAAAAAAACAAAAAACAATCGCAAAAAAAATTCAATGTTTGATATTGAACGGGACAAAACGGAATTTTTTCGTGAAATATTCTGGTGAATTTTTAATATTGAAAAATTGAACGAACAGAAGGTTTCTTGTTAGCTTTTTTGCTGAATCAATTACGTAATCTATTTTTTGGTTGTTTTTGGTTTTTTTTTCTCAAAACCAGCGATAAAAAACCAATCAAATCAATTTTTCCCAAACATACCAAAAAAAACCAAAAAAAAATGCCCAGCCCTGGGTCCCAATGTACAGGTGTTGTGGTGTGTGAGCTCTTAGGCCAGCTGGACTTTTCTTGGCCACTTGTAAATCAATAGCTTTTTTTCGGTGTTCTAGGCCACCTGTCACGCCTAGACCATTGACCTAGTAATGTTGAATAATAAGTCCAAGTACTCACATACCCGCAAATGCACATATCTATCTTCATTTCGTGATCTTATCTCTTCATCTCATCTTATTTTCCATTTCGGTTTACCCTTTTTTTCTCTATGAATATATTTTTCATGTACTCGCTCTTCATTCCCTCTTTGAAAAGCAAGATTCTTTTACACTTATTTTTCCTTAGGCAGTTGTAAAGAACTTGTCATTAGAACTTTCAACATCAGAGTACGATGGCCGAATTTTTTCTAGGCCCACGGCTTGGGAGCCAAACATGGCTAAACATTCACTAACTTCCTAGGTCATCTAGAAGTTTCTAGGTCTTATGGGTGAAAATTGGCAAATGACAGAATTTTCTTAAGTAATAGTTGAATTTCCCGCCAAACCGATTTTTTTTTGATAACATTTAAATTTCCCGCCAAAAATTTTTTGAAACTAAATTTTATGCCACACTTTTTCTGAGAGAATTTGGTTTCGCTCCCAATTTTTCTCTGAAAAGTTTAAATTCGCACCTGTGTAAATTTTTCGAGAGCTTTTTGAAGTTCCCGGCAAAATTTCGAAAAATTAGACCAACCTCCCCGACCGTCAACTATGATAGAGAAGTGTCCTCTGTACCCTGGCCGAATTTTCAATATATTTCTAGACCCGCCACATATTGCCAGCTAAATTATGTTGTGGAAGAGTAGTGACGTCACTTGGCGACCGCGACCATCGAGGAGCGTGAGGGGAGATGTATCCCGGCCTTCCCAACCCTAAAGACCTCGCTTATCGCTCCTTTTTGTTGTATCCGTTTTTTGGTGTCTCGATTCGTTTTCTCCTGTTTGTTGTCATTTCTGAACTCATCTCTACACTTCTCTCGTCTTCTCTGCGTCTCTCCATCCTGCACACTATTTTTTACCTCGATGATCTTTCTTATTGCGTGTGTGTCACTGACGAACGAAAGGCTGACACAGACTATGTATTGTTTGTTTTGTTGTTTAGAAGTAGTTGTAGTATTCCAATCGTTTTTCACACTACTTTGCATTATTTCAGATGGCTCAGGACGGGCCATCACATTTTTGTCAGGCTCCGCCGCCGCCGCCACCTTCCTCGTGGATTCCAGCTCCATCGCAGGTAAATTTAAGGTTGCAAGCGCGCTATAATGACCTTTTTTGTGCCTACGCCTCCTGGGTTATTGCCAATGCCCCCCAATTCGAATTATTTTTACTTTCAGCCAAATAGAAAAGGAGCCGCTCATCGATGAGGAAACTGTTATTTACGAATCCCGAGCCACGTATTGGAAGGGATGTGAATGAAGGCCTCTGGCTCGTACGACTCGAGTAAATGTAGTGAGTTGGTCTAGAAAATTTGGTAAAGCTTCCACGAAGTAATTAATTAGGGATATTACTGCCGACACCCAGGAACACGTATACCACGGCAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATTTAAAATTTTAATATGAAGATATTGATTGGCGGGAATTTAAAATTTAAATTTTTTGAGAATATTTTGGCGGGAATTTAAAATTTTAATTTTTTGATAATATTTTGGCGGGAAATTTTATGAAATTTTTTGAAAATTTTGGCGGGAATTTAAAAATTTTTTGAAAATATTTTGACGGGAATTTAAAATTTTTATTTTCAAATTGGCGGGAATTCAAATTTTAATTTTTTTAAAATATTTTTGCGGGAATTCAAATTTTAATTTTGAAGCTTGAAAATATTGGCGGGAATTTAAAATTTTAATAATTTCTGAAGGTAATATTTTGGCGGGAATTTAAAATTTTCATTTTTTGAATATATTTTGGCGGGAATTTACAACAAATTTTAAGATACTTTTTTGAAAAGATTTTGGCGGGAATTGAAAATTTTATTTTTTTGAAAATATTGCGGCGGGAATTTAAAATTATAATTTTAAAATATTTTGGGAATCTAAAATTTTAATATTTTGAATATATTTGGCGGGAATTCAAATTGTAATGTTTTGAAAATGAATTATTTTGGCGGGAATTTAAAATTTGATGTTAATTTTTTGAACGGAATATTTAGGCGGGAATTTAAAATGGCTTTTAATTGTTTTGATGAAATTATTTTGGCAGGAATATAAAATCTTAATTTTTTGAAAATATTTTGGCGGGAATTTTAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATTCAAATTTTAAGTTTTTGAAAATATTTTGGCGGGAATTTAAAATTTTAATTTTCTGAAAATATTTTGGCGGGAATTCAAATTTAGATTATTTTTTCTGTTTCTAAATATTTTGGCCGGAATTTAAAATTTTAATTTTTCTGAAAATCATTTTGGCTGGAATTTAAAATTTCTGAGAAAAACCTTCGTGTCGAGGCACTCGGTGAGACCCTTCGTGGTGAGACCCATCGGTGACATCCATCGGAAGGTGGTGAAAATAGACCTTCGTAGTGAGACCCTTCGTGGTGAGACCTTTCGTGGTGAGAGGCTACCCATCGTGGTGAGACCCATCGTGGTGAGACTCATCGTGGTGAGACCCTTCGTGGTGATACCATCGTGGTGAGACCTTTCGTAGTGAGACCCACTACGGTGGTGAGACCCATCGTGATGAGACATCGTGGTGAGACCTTCGTGGTGAGACCCATGTGAGACCTTTCCTGGTAAGACAGGTTTTCGTGGTGAGACCCTGCATCGTGGTGAGACCTTTCGTGGTGAGACCTTTCGTGGAGAGACGTTTCGTGGTGACGTAGGACCCATCGTGGTGACACCCTTCGTGGTGAGATCCCCATCGTGGTGATACCTTTCGGCGTGGTGAGACCCATCGTGGTGAGACCCTTCGTGGTCAGACCCATCGTGGTGAGCAGACCCATCGTGGTGAGACTCCCTTCATGGTCAGACCCATCGTGGTGAGACCCTTCGTGCTGAGACCATTCATGGAGAGACGCAGCGTTGTGAGACCCTTCGTGGTTAGACCCATCGTCGTGAGCTTTCGTGGTGAGACCCATCGTGGTAAGACTCATCGTTGGAAACCCTTCGTGGGGAGACTCTTCGTGGTGAGACCCTTCGTGGTTAGACCCATCGTGGTTAGACGCATCGTGGTGAGATCTTTCGTGGTGAGGATTCCCCATCGTGGTGAGACCCATCGTGGTGAGATTTGGTGAGACCCATCGTGGTGAGACTTTTCGTGGTGAGACCCATCGTGGTGAGACTTCTTTCGCGGTGAGACCTCCCTTCGTGGGGGACTCGTCGTGTTTGATATTAGGCGAGGAGCTATGGAGCTGGAGTGGGATAATGTCAAGGTACTATAGGCGTCTTGTGGATTGGCTGTAGGGTTACTGTCAGTTCAGAAAAATTGACTTTGTGCTTTTGAAGAGGTATTGGCTCGAGAGTTAGAGACGCGGAAGCTTCTGTGTTTTTTACATTCAATGTTTGAAAAAGTAATTTCCAACAGTTTTCATGTGACTTGAAAGATTAAGATATGCGGTGTTTTAGGTGTCGAACAATTGAGATTTCGGCAGTCGTTGGCCGCGCCGTGGGCGCGGTCAGCGGCTGGTTTTTCCAGAAGAGGAATAAGAAATTTTTGTGGAAGTTACTAGGACCCTGAATAGAATTCTAGGCCATGTCGAAAAAGGGGCTGGGTGCACGTGGGAACCTTCGAGTGTTTGGATATTTTGGTAAGAAGTAAGAAGAAGGAAGGTCATAAGAAGTTGTTAAGAAATTGACTTTTCTAGAGTAAGAATGACTTTTCTAGAGATCATCTCCCCCTATTATTCACAGCGTCACCTAGTTATCCGGAAAACTCTTCCACCAAAAAATGTGCTCGCGAGTCCAACTGAAAAATGCGTCATAAAACACACGGAAAAGGTACTTGTGTATTACATGCCCTCATTTTAATAGTAGTTTTTTATGAAATAAAAACGTGAACCATAATTTGAATTTTTAGGCTTAGGAAATAACATTTTCTAAGCCTAAAGAGGAAAATGTGTAATACACAAGTACCACGGATAATTTTTTGAAATCTTCCGAATTTGAAATAATTTAACTAAAACTTTCTAGGCCACGATGAAAATAGAAACAATGTGTCCCGATTATGCTGAAAATTTCTGAGCTTCCATAGTTATATCGAGTAAAAAGATTTTCGAGAAATGAGTTTCTAGGCCACCAGAAAAGTTTCTAGGCCATGATCCCTTCTTGATCTCGTTTATCATTAGGATTATGATATTTTTTCAACGATTTTTTAGGCCACCAGGCGCAAGGGAAAGTCCGTGTCAAAAAAAAAAGAAAGGGGGTATTCTGCGTTTCCTCGTCACGTAAAAATCCCGTTGGCCTTTTCAATCAAATTTCTTCAATTTTTCGCATAAAACTTACCTCCGGCTGTGACAAGCCTCCTCCCGTCTCCCAGTATTCTCAATTAATCATCACCCCCAATGCCCTCATCCAACTACAGTATCCCTGCAATCCCCGTCTGCAAATATGTGCCGAATATGTCATACTTCTACGTCAAGACTACGCAGTCAAATCCGCTCATCTAATCACCGTGTCGATGCTCTTGGGAACACTGCTCTGTGTGCATCGTGTGTTGTGGTGAGCTCTTTCTTTGTAAAATTCAAAATAATAATTAAAACTTAAAAAAGAACGTGACTGGAATTTGCAATATAAAATCGTGGCTCTATACAAAAATTCAAGTTATACTTCCACATTGTCGTTCCAAAATAAAAAGAAATAGCCAAGCCTACAAAATGGGCGGCGCTTTCATAGCCACGTCCATTTTGTGGGCGGAGCATCAAACTTTTTTCAAAACCCTACTATAAGTTGAACACGGATTTCTGGCTTCCTCATCATAAATCGACAATGGCTGAGTTTGACGAACTAGGCCATTTTGGGTCGGAGACATTTTGTGTAGATTTACGGCGTGTTGCGTGTCGCGTCGCTCGTTTTTAGTTGTAACACTGCTTGTGCCGTGTACATGATTCCAGGTTTTCTCCACGCGCTGTCCCACGCGTTGTCAATGAGGAGCGTAAATTCAATGCGAACAGAAGCCCGTGGTTGAAGTTTGTTTTCAATACTACAGAAGATTTTAAAGAGGAACAAACAGCTCATGTTGCCTGGCTACAAAATGGGCGGAGCGTTGGAGGCGTGGTCTAAGAAGGTGGTCATCGCCCTTTTCTTTAAATACTTGTTCTGATGTACAATAGAGCGCATTTACATCAAATTAATAATTAGTTTTTTAATTTTTCCAGATGGCTGGAAACATATGTCGACTCGAAAAATGGGCCCATCACCACGTTGCGAACTATTCGCGGCTACGATTATCGACGTGAAATTCGGCATACTTCAAATGAAAACATTACATGTTCCACACGTGGATCGATCATCTTGTCTGCACAATTTATGGTGCTTTTGATCAATCGTATTAATTATGATATTTTGGTATTTTACGATTCGATTCATTCAGGAGAATCCTAGTTAGTCCGCTCTTAAAACGAAGGTGGGCGAAGTTTTCTGGTGATGACCTAGGAAATTGGAAAACTAGTGCCACCCTCGCAAATGTGGCTAAAATAAATTTGACTAATGGCCTGCGGCCTAGAAAAATAAAAGTAGACAGTATATAATAAAGTCTCATCAACCCTTTTGGAGAATGAACTGGAAACCCAAATTTTTAAGAAAATATTGACCTCCTTTAAAACGGTGGCCTACTTTTTCTGATGGCCCTAGGTTTTTCGACCAAGAAGCCACACAGCTCCATAGTTTCAGGAAAAAAAATAAAATAGGCTCCGCCCACATCTTCTTGCACGTTGAGTTAGAATATATACGAGCCATTTTTGCTAAGTTTTGAATGTTAGCTCCGCCCACATAATGATTTGAATTTCCCGCCCATTTTTCTCTCAAAAATATGAAGTGCCTGCCAAATTTTGCGAAAAACTCAATACTTTCAGGCTCTTCGCGCACGACAAACAGCGTACACGTGGAAACGGCTTGGCTAGTTCAGCGGAAGCGGGAATGGAGACGGGCGGTAGTTCGGACGGATATTTCTCGCGTACACCTGTCTCATCACTTTTCGACATAAAAGTGGTCTTGTGTGCCAGCATGTTCTTGGTCTCGTTCATTTTGGCCCTTCATCAGTATAAGTGAGGGCTTTTTTGACACGTGCCCTGGAAAATGATAAAACTCGGCCACCTATTTTTTCAGCCGAATTTTTTTAGTTTTTAGCGGTCACACGGGCTTCTCATTCTCTCTGCATTGCAGTTTCGCGCTCCATTGGCACTGGCTTGCCGGACAACGTAGGAAACTCGTGTACTCCACACGATAAAATTGTTCAGTTTTACATTGAAAACCGAGCCGTGACAAAGGTCGCCGTAACTGTACCCCGGCCGTGGCCGGTGAGTCAAAATGGCATAGTTCGGCAAATTCTTGAATTTCAAAATATGATGGAAGCCTGATAGAGCACGTGCGGTGATAAAAATGAATAAAGTATCCTGTTTTTTTTTCCAGAGGCGAGTCCACGATATTCCGATGTATTTTCCGATTCGCTTTTGTGAGCTCAATAAGTATCGGCGCGATGATCAAAAAGATATCAAGTTCTGAGTGGGCGGAGTGTATCGGCGGGAAATTCAGGCAACTTTGATCTTTCAAAATTTTCATAAAAAATTCGCGCAAAGATCAAAAACTCAAAACTTTCGGTTAATTTCGGCGCGAGATTCAAAATGTTTTTGGGAAATTTGGGAAAATCTAAAAAACGTTTAGGCGTTTGAAATTTTTTTAATTTTCAGAAATGATCCTGGAATGGCTAATCGCCGCGGTCTCCTGAAGTCTTCATATCACCCGTTAACCGTACTTCTGATATGTGTATCCGCGTGGCATCCTAGTCATCTACGAAATAAACCATTCGCTCAGTTACAATTTCTCATTTCTTTACCACTTTCGGGTTTTTTGCAAATTAAAAAAATTTCGATATTTTTTTTGAAATTTTAATTTTCCAATATTTTTATTCCACAACTCAGGTTGCTCAACTGTGCCTAAAATAATTTTTATTTCTTTGATTTTTTATAAATTTAATACAATAAAAAAATAATATTACACATTCGTGAAACACGGAAAAAAAATTCAGCCTATTTACATTAAAACACGTGGAATTTGAAATTTTAGCGATATATCGATTACCCCTTCTCGGAAAACTCGTAATAAATGTGAAAAAGGCGAGGAAATTGGAAGAATTAAATGCGGGTGTGGGTTTCTAGAAAAAAAAAAGAAAGTAATTAAAGAAAAATTCAAAATAATGCTCCGGTGTCATCGTGTTCCACAGTGGTTAGATTCTGGTATTTTGTGCTGATGGTGTGCTCTGAAATTTAAGAAAAAAGTAAAAAATTGAAAAAAAATTTCTTAAAATAAAAAAAATGAACTTGTTTTTAAAATTTAGATTCAAAAATAACAGTTGATATATTATTCATACATATGTTATCAATTTTAGAGAAACTTCAATTTTTCAACTGACTAACGTATACAAATCTACTCGAAAAAGACCTCGGAACTAGTTTCTCACTTGGTGGCCTAAAAATCGCCACTAAAACCATCGACCAATATGAGTTTGTAGGCCTCCATATGAAAAAAAAACTCGATCGGGGACTAGGTTTCCACATGTGGCCGATTATCAACTTCAAATGTTTTGGTTACCTAGATTTGTCAGAACTTGGATTACTAGTCCACTAAAAGATTTTCGGTGGCCTAGAAACCAAATTTGCGTGAATTTTTCATAATTCTATATCAATTGACTAAACCGAAAATAATGCGATGCTTATATTTCATCAGTTGGTGACACTATCCCACGTGGCGACGGGATTACGGGCGACCGTGCCATTGATTAGAGCCAAGGGAATTTTGAGCATACTCGTCGGCGGTGCACTTGGCGCAAAAATTTTTTCTCTTCCGTTAAAGACGCATGGTGGGTCTTGATCTAAGAAATTTCGTGATTATTCGAAAATTTTTTCCTTGTCCTTATTGACAATTTGTGTTTTCACAAAAAAGGCGGAAGTCCTAATTGCCAAAAATGTAGGTTTCTAAACTAGGCCACGAAAAATAATTCAGTTTTTTGCTTCAAACATCCTGCTTTTTGTCCAAATTTCGCTTTAAATTGGAAGTGGTGTCCGAACATTATTAACAAAAGTTCAATTTCTAGAGAACATCACTTTGTTCTAATGGGTATTTCCTCACATTTGGATTTCTAGCCCACAAATAACGTTTTTATTTCATATTTTTATAAAAATCGAATTAAAAGTAGATGATGACCTAGTTTTTATCAATAATTTGGGTTTCTCGGCCACCAACTTTTTAAACATTTTCTTAATTTTCCATAACCAAAAAAAAAAAACAAAATCGATGGCCTAACTTATTGCGCTTCCTAGGCCACCAATAACTCTTTTATTACTGATTTACCTCACTCTATGATGTCGATATTTCTAGTCTCGACTATCGCTTCCCACAGCCATCACACTCAAATGCTCCATTCGTCTCATGAGTGAGCGAGTGTTGATTGAGCCCATGCTTCGGAAAGTTTTCTCGCAGTCCGTTATAAGGTTGGTTCCATTGTTGGGCTGGGGTGAGCCGACGACGGGGCCGCCCGTATTGTCGCCCTTTTCCCGGTTTTTTCCGGTGAAAAAGTGTCGAAATAAACGCGTTATTGTCGTCTAATTTTGGTACATTCGCCGACATTGCGAGATTCTCCTGAGCCACTGTGACGTGTAATGTGATGGTGCTGATAGAGGTCTGGTGGTGGCTGAAAATGGGGAATATTCCCGGCCCCGAACATTTTCAGAAGTTCCAGGTCGAATCGTTGTTGAGCATCCGCGTCGACTACTTGATTGAGGGAGACGGTTCAGTTCAGGAGACTGGTGGATGGCAGTTTTATAGACATAAATCCTGCAAAAACTCAGGTTTGTTGCTAAATTTTTCAATTTATCATTCTCATTTCCGAAAAATTATAGCTTAATTTTAATAGATTTTTCGCTTGATTCTCAATTTCTCGAATAGTTTTGTGTCAATTTTTTTTTGTTTTAAATGTAAAACTACGGTATTCAAAGGGAGGAACACTAATTTATCCCGATGGGGCTCGCGGCGAAAACATTAAGTGCCTTAATTAAGCCTTGCGCCTGGAAGGTAACTGTAATTTTTATTGATTTGATCGATTCATTTCATTCAATTTGTGGTTTTTGAAGGTTTTCAACCCATTTTGAAAGCTGAAATTTTAGATTTTTATTTCTGACAAAAAAATTTTAAATGTTAAAATAATTTTTTTTCTTTTTCACACAAAAATTGTAACCGAAAATTCCGAAAAAATGCAATTTAAACAGCTCTAAAATATGAAAATTAACGCGATTTTTATCATTTTTTGCTTCAACTGACTTCTGGCAAAAAAAGGAAAATTCAGCAAAAATCAATTTTCCAGAAAAATTTGATTGATTTTTAATTTTTCTTAATCCGTCGTCCGTACCGTATGTAGCTTCATCTAACACCTTATCCAGCAGATTGCTTACATCTAATTGCACGTGGTTGCAGTTCTGAAAAAAAAATGTTTTTGAGTTTTAGAAAACTTATTTTGTAAATGTTCTAGGTGGGTTTTAATTGTATAATTAAATCAAATTCTTATTCAGTTTCTCCCATAAATCGCTCCAATTCCGCTTCTGATTTTCCTGAACTTTCTCCACTTGCCATCACGGCCAAATCCTGCTGCTCACGCAAAAATTATTTGACAAGACACGTTAGCTGGTTTACATTATAGATTGCTGGCATTTTTATAATCTGAAATTTGAAATTAAGGATTTTAGTTATTTCCGCAAAACGTAAACTTTTATCGCTGGGAAAACTCACATTTTTCGAACTTCGCCCCAATAATCGTCTAGTGAATTCTTGAATAAACCGTTTGCTTTCTTGACATAAAATTCTGAAATACCTCATTTCCCATGAATTCGCCCATTTTCCCATGGAAGAAAACCAATGGAAACACGGAAATATTTGCGCACAAAATCGATGCTGAAGTGTCGTCGGACCCAGTGTTTCGTGTGCAGTACACGCCTACGACAAATTGCGGACTTTTTTGTTATTGGAGAGAGTAGAATAGAGAAGAAAAAAGAAGATAAAATGGATAAAAATTGCGCGTTTTTCTCATTGTTTTTTCTCTGAATCTCTCAATTTTTAGGTTTTCGGTCCATATACGTCCCGAGTGGAGATGAAGCGATAAATTTTTCGCTAAAAGTTTCTTGCCCCTCCAAGTCGCTTATTCTTTTTTAATATGAAAAAAAAATGCTAAGATGCTTATCAAACCGCAAATTTTTTATTGGAAAGTCCCCAATATTTTGCAATTTATTGCTCAGTTTAAATTCAAGGTGCCATTCTGCAAAATTGCATTCATCTTCATATGTTACATTTTTTAAGTAAAAACTTGAAAACTCTGCTTTACATAATAGTACTGGAATTTTTCAATTTTCAACATTCAGGATAATCTTTGACCATTTTTTATTGAAATTTTCAATAAAATATTTAAAAGATGTGGCTTTCCAAGCAGATTTTCCAATTTTTCCGAGTTGAGTAACTAAGTTTCAACCAAAATGATGTCACAAGTCAGAAAATTTCCCTAAATTAAACAAATGGTGAAGAACTTGATATAGGATTAGAACAAAGATTGAGTCTTGAGATAATTTCGGACATTTTCGGAAAATATACGTTTCCTGTAGTTTCAAATAGGCAATTTGACTTAAGGTTGCTAATAACATTAAGAAAAATCTATAGTCTCCACCCAATTCAGATTGGTTTTGTAGATATTTTCAAAATATCGTGTAACGAAACTACAGTAATGCCCACTTTGAAATTAAACTTAATCCTGTATTGCTTTTGTCCATCTACGGGCTCGATTTACGAAATTAAATTTAATAATCTTTAATCTATAGAATATTAAAATTAAGCTCTAAAAAATGAGAATATAATTACGTAGAAATGAAAAATGGAATCTCGGTGTAAATATCCGAAATAAATTCATTTAGAAAATCGAGCCCGTAAATCGACGTTACGAAGAATTACTGTAGTTATCGCTACGAGATATTTTGCGCGTCAAATATGTTGAGCAATACGCATTTTAAGAATTTACTGTTATCGTAATAGTTCAATTTCGAGATAATAATTCCAAAAACAATTGTGAATTTAAGGTTTTTTCCGTAATCTAAAATTGATTATCACTACACTGGACACTGTTCAAACTTAACCATTCAGAACTTGTATAATCCATCTCGGATAAATTGTTGGTGAGACAAAGTGTAATCTGTTCTAGTTGGGTCACACGATCCCTTTTCCACTCACATCGCTTACCCACTCAACACTATAGACGATACACTCACACAGGAAATAGTATTGTTTACCTGTTTTCTTCTGGACACTGTTTATAACTTTTCCCTGTATCTCCGTTTCTCTACCTTTAAATTTATCCAAAATTAATAATTTTTTAACTCCACATTCAATACTCATTTAATGACCGGTATTTGCAGAAAATATTTTATTTTTATTTAGTTATTACAGGAACAGTATACTCTAGGAATTCGTATTGCACAACAGATTTGACGCGTATCACGTTAGCTGGCATAATATTAGGCATTGTCTCTACAATCTTGTAATGTATAACTGACTCTTTGAAATAAGTTTGTAAAAATTGTGAGTAGGAAAACATTGTGCATGGATGTCGCGTTTCGCGCACGCGCTAGAGTAGTCATAAACCGCAAGATTACTGTTGTTCTCGCTACGAGATATTTTGCGTTCGGCGTCAAATATGTTGTGCAGACATTTATGCATTCCTCAGAATTTTGTGTTCACGTACTAATAAATTAACTTGTTAAAAGATATAATAAAAAGTGTTAAAAGATACAGAGATCTTTTCTCCCTTCCCTAATATGTTTAACTGCATATTCAATCATCTTAAATTGTGCCGAAAATTTTTCGTTGTCCAATTGTTCGGAATTTTTTCGGTTTTGCTCGAAAAAACCAAAAAGCAAAATTTTATAAATTTCCCTGGTGTTCAAAATTTTCCCGCAATTTTTACCGATTTTATTTGCAAAATATTTTTATTTATTTGAGTTCCCCCATGTCACACCGTTCGATGTTGGAGAAATGGAGATAATTCCGCTGCATTACGGAGCACGTTGGGATTTAGGACTTGACGTCTTGGCGAAAGGTTGGTAGATTTTAATTTGTTTTTTAAATCCTGGCCTTGCACATTCTAGCAGGGAGACGTCACTCTGAACATTGTTCAACATATGTAAATTTTAAATTCAAACTACTTAAAACCCGGAAATCACTTTGTGTCAGATACACAGAAATAAACAAGTTTTACCTTTTAAAAAACTTAAAACCATTGAATTTTTCACAAATGTTCTTTGAGACTTGAGATAATCTAAATCCCAAACTTTTGGAAAAAAACTGAACATAGGTAGCCTAGAAAATGAAAATTTTCAATAGTTGTGTTTTTCAAGTTCAAAGAAAAAAAATTGAATTTTTAAATCGTTCTTTTTTTGGCTACAAGTCAATAATGATATTATATTTAGTTTTTAAGAACATTACTAAAATGAGTGCATATTTAAAAAAAGTGTTTGTTTCGGCGAAAACAACTATTAGTAATTCCGTGCACTGCAATCATCAGATTAGTGAGGAATTTAGTTCTATTTTTTGCTTGTTTTTCTGTTTCAAAGTCGTTTTTTCATGAAAAATAGACCTTAGCTACAGGTTCTTTTGAGAAATCCCGCATTATTTCAATTTTCAATTTCATGATGAACAACGTTTTTGGTAACACATTTAATTCTAGTAGAATATTATCAACTTTTTCTCTAATTTTTCAAAATTTACACTGTTCCTAATAGTTTTTCTGATCAATGAAGGACTACCATTTTACGACAATATTGCCTTCAATTTTTTCTTCTGAAAATTCGAAATTGATCTGAATCAATGGTGCCGGTTTTCTTATTTCATCCCTGAATAACGAAATTGATTTTTATTTATTTTTCAACAATTCCCGGAAATTTCTCTATAAAACAAATGAAGTGAAAATCGATTTTTTTACTTCGAAAGTTAAACATGAAATTCGATAAATTTAATCTATGATCTTTCAAGCTCCGAGTTTGAGGCGGGATGTTGATAATTAGAGATATGCCGGGGGAGAACACGACTCTCCAATTATATCTTCGGTCGAGAAATAATTTTAAACATCAATACTATACTAGATTCTAAAGAAAACTAATTTTTTTCAATAAATAAGTGTTATTATTATTCAGGAGAATTATTTTGCTTCTTGCTCGAAAGAAAATAAATCCGAATCAAAAACCGACGCATTTACAAGTCCTGAATTTTGTAGTTAGTCAGAGATAGATTTTTATTTAGCCTCAAATTCTAAGAATTCAGACCTGGCTATTTGCCGAGCCTAGAAAATAGAACAACTAGGCCACCGATCGAAGATTTTGTGTTTTGCCGTTGTCAGGCTACTGGCCTAACTTTCTCTATCTTAAAAGATTCCCAAAGTCAAACTACTGGCTTTCCAAAACCTTAATGTAATGAACTTGTGATTCCAAAGATCTGATGTCAAGAATGTCCATAGTTCATATATACTCCAACGACACTTTTGGAATTTATTTTAAATCTTCATGGTTTTCAAAAAGAATCCACCAAATTATTAAGCAACGGGGTTTTCCTTTCTAAACAATTGTGTGACACAAATCAAGGAATTCTCCGTCACTTTGTACAATTTTTCTAGTTTTGGTGATTTCCCCTGATGAGCTCAACGCCAGGCGGAATAGCTCTTTCCATGCAGGCGTTAAAACGCCTGCCTGCCTGACTTTAAGGCGGCCTCCGCCTGCCTAACGCTTTAGTCCTAGTCATGTGCTAAACCATACATGAACTATTTTTCTAATTCTTAGTGTCTTAAAATTGATAAAAATTAGGAAAATCCTTTTGAAATCTGAACTAAATTTCAAGTAAATGGGCGGCAAACTTTGTATAAAAAAAAAAAGAAAGCTCGCCCACCACTTTTTCAAAATTTCTTGCCGCTATCTTGACTCGAAGGCGCAAAGCCCTAAAACTTTAGAAAACATCCCCGAACAAAAAAGTAATACATCCTTCAAAGTGTATGCCCCCCCGTGTATATGTCACCTGTAGACTCGTCGAAAACGTTTGTGCCACCCGGCTCTTTACCTCGTCTCCTCTTACTCATCATTTTATGCCCCCGTAGCTTTACCGTCGGCTAATGTGGTTCTTAGGGCGTAGGACGCCATTGATTTTGCTCTTTTCAAATTTTAGAATTTATTTCCCGGTCTGATTTCACTCAATTATCAGACACCACATCTTAGTTTTTTGACATGTTCAATGCTGGAAGCAATTTTCGATTTTTTTATCGACCATGGCCTACAGGTAAATTACGGGTCAATTTCCTGAAACGGACGAACATTTTTGAAAGCAAAACAGTTAGTTTCGCTAGAATTTCTGATTTATCGAAATAAAATCGGGCACACCGAACAAAAGTTCGTTTGTGTCAGGAACTTAACGGTACGCACTTTTGCTCGGACAAACCACGTGTGGCTGATTCAAAAATGTCCAACTAAATTGACGTCTTGAAAACATTTTTTACCTGAAAACCGCTAACAATGTCAGGTTAATCCGATTCAAGCGCTATTTTTATAAATCCTGAAAGTTTAAGATTCCACACGTTGTGAGGGAAATTGACACATTTTTAGAAAACCTGACCTCACGGTTAATTTTTAAACACTTCGAGGGCCCAGAAATCCTAGTTTTTTTTCGGGTTATTCATAGTTTTTCTAGAATTTAATTCCACATCTACATTTCTAAACAAAACTTTTGAAGGTCCTTGTAATTCTTCTCTAGTTCTTTATTGTTATGTCTTCTCCAAACTAGGACGAAGCGATAATTACGGGGTTTGTGAGGGAAGTTTGTCGTCGGTCCATTTGTTTTGAAAATGAGAATCGGAACTTTCCTGTCTCCCGTAGAAACCAATTAAACGACAACTTTTTTTTTTCATTTCGTTCATTTTGCAGGCATGCTAGCCTCGTCTATTGGAATTGTTTTGTGAATGCTAGTTGTGATTAAAAAATTAATCGATTTTTTTGTAGTATGAGTTCAAACAAGCCGAAAAAATAGATCAAAACTGAAAATTTTATAAGAAAAATTTCCGTATCTAGTTTTCAATTGGCCAACTTATAATTTATATACTCTCGAAATCAAAAAAAAATGTACTTCCTATATTACCCACAAACATCGAAAGGGAAATCCTCTATTCCCGTCAATTATAAGAAATGTGAGAAAATCTTACTCGATTCATGGTTGCTATGAGACAGATTGCAGATGTTTCACCGGATAAACAAGACGTTATCATTACTTTTCAGTAATGCTCGTTTATTTTTCTATTCCATTTCTCGAATTTTGATAGATGTTGTATTATTTAGAGAGCACTAAATTCTAAGAATGCCATCGTATTGCGCAACGTATTTGCATGAGGCACAAAAAATCTCACAGCGAAAACTACATGACGTAATCCTTTAGCTACTGTAGCGCTTGTGTCGATTTATGTAAATCTTGTCATATATTCGTCGATATAAATTGAAAATTAAGATAAATAATAGATAAGCGAAAAATTAATATCGAAAATCGAGATTCCGTAAATGGACACAAGCGCTACAGTATGTAAAGAATTACTGTAATTTTTGCTACGAGATATTGTGCGCGTCTAATATGTTAATACGCATTTTTAGAGTTTTGCCTGATTATGTAATGCGTATTTCCTCTGCATGCAAGACTAACGATTGGTCTGTAGAGGTCAGTTGGCTGGCTGACTTTTAATACTTATGTTCCTTCAAATGTTCAAGTACGATTAGGAACCCTTTCTCTCATTTCACTAGTTTACCTTAATGTGTGTCTTTGGCTAGCTGAGACGATCATCATTTCTTTTGTTTGTATTTCGCAGGAAAATTGTGAAAAAAATTGCAAAAAATTGAGAGCAAGAAAAGTAAGTGCACACCGATTATGACTCGTTGTACCACGATTTCCCCCTTCGTTTTCCCTCTAATTACCTATACGTATAGGATTAACTAAACATGATCCCGGGGATCACCAGTTCATAGTTTCCTTATCAATTTTATATTACTCGTATGCCTTCCTCGTTTTTTTTTCTAAAGCCATGAAAATGTATCGCAGCGGGTCGTAGCAGGAGCACAATGTACTCGAGCTCGTCACGAAGGCCGTACGGCTGGTTCCGCTTATTAAATGGTTAAAGAACTGGGTCTTGATTCCTACCAAATTCATTTTGATAAATAGTCCCTATAGATCATGTAATAATATAGGTTGACCCTACCGTGTTTTCCAGAATAAAGTTTTACAATAAACTTTATAGCATGGGTGTGCGGCAACGATTTGGGCGACTTCCGTTTTCCGAGATCAAATCCGAGTTTGCTGCACACATGAAAAATGTTTAATTAAGATTTTGCGCAAAATGTAGCCCCTGGTTTACACCTTTTTACGATATTGTGAGTACATTCGAAAAGGATGTTTTGATTGAGTATCCCCAAATCAAAAAAGAAAGTTGATGAGAATTTAAAAACTTTTAAAGAACACATTTTCAGGCACAAGGCCGAACGGCAACCGACTACGCGGGTCAGAACTACGAAGAATGTTATGATAGGTTAGATTCTTTTTCTATTATTCCATTCAGAATATTACGAATTAATGCTTAAAAAAATTTCAAATTAATTTTCGCCGAAATCATCTGCGCCTTAGCTCCACCCAGCTCTCTAGATCGCAACCCGCAATAAAGCCCATAAATCAATGGGCAGCTGCTGCATGGTCCGTAGTGTATTAGTCTGTCGTCTGTCCGATCAGTGCGCTCCCGATAATACTCTCCATTTGTTTCTCGCTTTTTGTAAACTATGTGGTCGACAGACCGTTGAAAGTCGTATCAATTGCACTTTTGTAGTTACCGATAAAATTGCCCAGATCGACGAGTTTTCCATAACAATTTCTCTTCCATTTTCATCTAACATCTGTGACCCCGCTCATTAGTGTTTCTCTAGCCGATGCTATTCCAGGTTCCCATGGCAATGTGTACATGTGTGCCTCGTCGAAAGTGAGCCAAAATGCTCTTTGTATTAGGTTCATTCATCCTATGTTTTTTGTCCTCAGTGACCTGCAACTGCGCAGAGTTAAATATTAATTGGCACTGAAGAGAGGCCGCTCGGGCAAATAATTTTACAAATTGATTTATATTTGAAAAATGAGACACTATGTTATTATCGCCGAATTCGTTCTCTGAGTATCGCTGCGTTCATATCTTTGCACAGCTGCTCTATGAACAATTAAAATAATTTGTGGGTCCTGTAACGAAAAACCCGAAATAAGTCTTGCCTATACAGGAGTTTGTGGAAAGTTTTCAAAATTTTTGATCAACGAAGGAATTTGGAGACGTAATACGATCACTAGCAATCTGAATTTCTACTTTTGTGCCCCAAAATGCTTTTTTCATAAGTCCCATTATCCAAAATCCGGCCACCTTGCTAATCATGATGTCCATAATAGGCATTGAGGCAAATCTAGCGCACTTTTTTGTCCGATGAAAGACTTTTTGATAATACCAAGCTTAAACCTTATTCATATTGCTTTTAGTAATCCTATAAGTTTTGTTTGCAGTGGTTCAGAATTGCCGAACATTCCAAATTTTTTGATAAAGGTTTTACATATATGTTGAGAAAATAAACTCAAAAAAATTAACAATTAGTTCATACGTTATTAATTCCAACGAGTTTTAGTGTAAATATATATGTGGTCCTCTATATATTTTGCGTATTACTATTATTATTGATTCCCTCCAAAGCTGAATGTCAGTCTCAAGACTACCACGTACTGCTCAACTGTGTTGATTCCCTAGTATTTTCAAACGAACAAAAAGTGACAATACAGTATACTTTAAACTAACAAAAAACTTTGTCGAGTCTATCGATCAAACTAGCGAAATCCGCCCGTTAAATCGGTTCTGTTTCCCGCCACCAACACTTATTGTGTTTTCATAGCTTTAACTCTTTGACGGAATTTCCTTTCTTCCGATTTTTCAAGCGATATTTAAGCCCAAAACTTACTTCAAAGAATCTTAAAAGGGATTTTTACAACACTCTGGATCAGATTTTATGAATTGTTTCATTCGCAAGAGAAGAGCGACTCAGTGCTATAAATGGAACATTCACCACACTATCTCCACATTTCATCTCTATTAATTCATACAAGGACACTAAAATAATCCCGGCCCACTTGCTCAGACTCTGTCTCGCGGGGGACAAATTTGAATCCATTCTGTCGGTCGACCATTGAACCCCCACCACACAATATGGTTCAGCGGGGGGAGGTCCAGTTTTATGGCTTGTTATTACGTATACTGCTAGGGGAACCCAATTTTACCGGACCCCGTGCGGAATATTCAAATTGGAGTGTGTGTGTGCAAAAACTTTTATGGTCCATGTCCAGCAGACCAGCCAGCAGCTGCTCCGATCAATTGCCGCTTCAACTTTCTCCACTTTCCCATGGGACATCTAACCTTATTTGTCGTTCTTCTAGTTTCTCCTCTTACTTCTTATTCTTCTTCGTTGCCCAAATTGTGCTCGAAGAACTAGAGATCCTGAATAGAAATAGGAAAAGAGCACGAAGACATTATTTATGTCTTGTTGTCCATGGTTCGCCTCGAGTAGTTGATTAGGAGCTTCTCCTTGTTGTCTTCACTCGGTCGTGTTCTATATTTTATGTCCACTCTTGAATTCCTGGAGTTTTCAGTGCCCGCATTTCCTGGTTGAGCAGTTAGAAAGCTGCAGGAGTTTCCAGAATTTGATCGATTTGCGGAGTCGGCTGTCGTACTACTTACTTCCGGATTATAAAATTCTGAGAATCTCGCGTATTGTACACCATATTTGACGCGTCAAATTATCTCATGGCGAAAACTACAGTAATTTTTACGCGAGAAATAGTCGAGGCCCCCTAAATCTAGAGTTCCAAGAGCTACAGTAGTAATTTGTTCTAACAGAATTACTTCCGAACCTTTCTCATTTTTCAACAATTTTTTAACTTGCGTAGCGGAAAATTAGCGCTAATCGCGTCAAGACCCAAAACAAAGCGCCAATTTCATCAAGAAATTTGATGTAAAAGTTTGTGAAAACAACCGTCACTACTTCTGATGACGAATCCCTACTTCGACCCGGGCCCAGTTCGTTAAACATTTTTGAATTTACTGCCACCACATATCTTACTTCATCGACCAAAATTCAACGTGCTGCGATCATCATCTTCATCTCTGTCTCATCATCTCGCCCAAATTCAATTCCGTCACTGCGGCTCGTACTGATTTTTTTTCATTTGTCAATCATTTAGAGGCCAATGTTAAAGACCTCCTCTCAATTTTTTTCTGTCTGTCATTGACCCCTCTGTTGCGAACCGATTCAGAGTTTACAGGGTAAACAAGCTCGCTTTGTATATAATGTTGATTTATGTGAGCGAGATAGTGAAAGAGAGAAGAGTCTTGTAGCAGGAATCTAAGCGTTTCCTTTGTTTCAAGCTCTGTCAAAGTGTCAATCGCTTTCTAGCTAGATGATTCTTATGAAGCTTTGAACATTCTAGATTTAGTTTGTTACCTTCAACATTGGTGGTCTTTCTTGTCCAGAACTGGATAAGATTTATCGTAGCCTTTTGCGAAACAGTATCAGATTTCCTGCAGGTTGTACAAGGGCTTTCGCGAGGCGGTAAATCGCCTGCCTGACTTTAAGGTGACCTCCGCCTGCCTCTCGCCTCAATACGTTATGCACAAACGGGAACTTTTAAAAAAATTTTTTCAACAAATTGATAAAAAAACAATTTGAAATTTAAGGTCCCTGCCTGCCATAGAAGCCCTACCGTGTTCCACTATTGATGCGCTTCATTCTATTACAAATCAATGTAACGAACTCCGAAGTTTGATAGCCCGAGGCGTTTTCCTTGTTAAGTTGATATCGATTATCAGTTTGACCAACCAAACTCCATCGAGTTGGGTAGATTTTCAAGGAATTTATAGAATTTCGTAGAGTTTTGGACTATGTTTTGCAACGTTGAATGGAATTATATTTGAATAGGATATTGAATAACTTGTTAATGGTTCAAGGATTTTAGCACCCTTTCCGAAGTCTAGAAATGTTCCACCCTCAGGTGCCGATAGTCGGCTCCCGTGAGAACTGTAAACCGATAATCAATCAATATTGCGGGTATTAATTGGCTAATATACATAATCCCCCTGAAAAGTTATGTGAATAACGGCAAACCCCAAGAAAGAAACGACCATTTCCGAGGTGTATCAGAATTTTAACAAGACCTACTTAGGGTACATAACCCTATCAGTTTCAAAAACAGCATGTCGGGATTTTGTGCTACCATGGTAGACAGGCGCGGAGGGTCTGATGCTTGCCTGAAAGCCGGGCAGACAGGCGTTTTAATTGCTGCATGGAAGCCCTAAAATTCCGCATATACGGAACCTAAGCCAATTATCAAATTCTACTTAAAAACTCATTCCACAGGTGTTCCTGTTCTGCTGCATCATCGTCACACAGACACTTACACGCGGCTTTTCTCATTTCCCACTTTTTCTTCGTTTTTCTCGCTTTTTCTTCTTCTCGACACGACTTAATATTCGGATGGATGACGCCGAAAGCCAAAAGTGTTTCCGTCGGCGTTTCCACGCGCACTCGTACTACAAGTGCCACACTTACACACTTGAAGCAAATAGAGAGAGGTGCAGGAGGGAAAGGAGGGGACAACTTCTGTAAGATAAACTACCTCTATTTGAGTAAAGAGTGCAAGAAATATATGCGCGTGTGTCTAATGAGAGGGTCTTGGAGCGATTTTTAAGCATGTACAGTCATGAATCAGGCGGCACGTTCCAGCTTTCAGGCTCTGAAACCGCGTCTGCATACCAGGCAAACCCAACGATGGTTTTTCTTTGCCCTCAGGGATCCGTTTCTTGGATAGTTTTAGTCTTCGTCCTTTTTTCTTTCGTACACTTTTTGTAACTGTTCAATAGTTTCATCTAATCGTAGAAATTCGAGAAAAAGGATTTTTCGAGGGTCTGATAAAAGATCCCAGAATGTGTCTAATTCTAATTCTCTCCAAATGCCCAAAACGAAAATTTTTCGACAGATCCTCGTATTTCGAAATTCAGGAAAACATTCGGCAAAGCTGAAAATGTCACAACTTGCCAAAATGAACAATTTCGGCAAATCAATAGCTGTATTTTTCAGCAACTTTCGGTAAACCGGCAGTTCGCCAAAAAAAATTCGGCGATGGTCTCGACTCTAGAGTTGGGCGGCAGACAATTATTTCGGGCAAACGCAAAAATTAAAAATGGAAATTGGTGTTCGGCAAATCGACAATTCCGGAATTGAGAGTTTCCTGTAAATTCGGCAAACCGTTTGCCGAAGGGCAACTTCTCAGAACTGACACCCCTTCCAAAAGTCCGAAATTTTTTTAGCTTCACCCCCTTCCCTCCCTTCTCCGGGTTTTTTAAAAACCGGACGCACCTCTTACAATTATTACAAACACCACTACCATCGTACGTATTAAACGTCTCTCGTAATAAGGGGGGCCATAATATAATGGTTTTTGTTGTGTTTAGTTAGCCTCCTCTCTACTTCTCCACCATCATCAAAGCTACCCACAATAACATTACGATCATCAACTGACTACTTTTGTCTTTCAATATTTGTAGTTGTTGGGTATTTGAATTCTTATCCACTATATAGCTCCATCCCTATGTTGAAAATTTGAAATTTTTGGTAAATTTGAAAGATACCAAGTTTATGTATATTATAGTATATTATCAAAATTTCCGGTAAATTTATATCCTGCAAACCGCAAACCGACAATTCTAGCCGGAATTGGAAATTCCCGGAAAACCGCAATTTGCCGATAATAAATTTGCCTTTCTTGATTCTAGGTAAAATTTAGTACGTGATCCGTTTTTTCTTTGTAATATTAAAATAGGAATATCAAAATTTTTTATTTTTTTATTGCAACTGCAAATTATGTTCAAATTTTATAAAACAATTGTAAGTGTGAATTTGCACACTAATTAATTTTCTTATTGATAGGTATCAGTTTTACTAGCGGGCTATCATGTATGTACCAAAACGCCTACGGCGCCTTCTGATCTAGTGCGGTGTGACCCGAAAAGTGTCGGAATCATCTTTCGCAGTATGTGGTGCTGAAACCAAGCTTTTGAGTTCTCGCCATAGTGCGGCGAGAGGACGGCATGAGGCGGGAGACAGGCTAGTAGCAGGGCAGGCTTCAGGTACTGTGTCGCGTCTGCCTCCCAATCATTTTTTTTCAAAAAGTTGCAATGGAAATCAGATTTTCAAACGCAACCTGTCTTCCCCTTGTACTATCACAACTTTTACTTGATGATAGTCGATAAAACGCTGGTGTGAACGCGGCGAGGTGTAATCGTGTGACAATACAGCATTATTCTTTTTCGCAAAAAAAAACATTCTTTTGGGTATTATCATTCTACCAACGTATCTTATTTTATCGATTGGTTTTTTCTCCGGCGCGGAAAAGAAAAAATTGAAAAAAAACGTCAAAACAAAAACATTTGGAAAATATAAAGGTGGATATAAAAACGGTTTCGAACTTTTTTTTGCCGCGAACAGAGATTCATTTCCTGTTAACCATTCCTACATCTTTTGACGCTAAAGCAAAACAGAGACAGTCGAGACTGTCACATAAAATATACGTTTTTTGGTATACTTAATTATTCACAGGTGCCCCTTTCTAAAAGTTTAATATTTGTCGCGAAAAAATGCAAGAAATGTTTTTTTTCTTAAAACTAAAAACTCGAACTCAAAAATAATAATTGGGTATTTAAACATTCCGGCATCTGGGTCCAATTTCTTCCCGTTCCTGCCCTTCCATTTTTTTCTTCCTGCACTTACTCGAGTATTCCGGGATCCTCTTCTATTGCTGCCATAAAAGTTCTTCCGCTTCACAGAACTGCAGCGTATCCTGCTTCATATCTCGTTGCTGAACTCCATATAGGTTGTCATAGCTCAGTTTTAGACGGATTCAGGTAAACTCGAACTTAATTTCTGTAGGGTCTCTAGGATGAAGTACAGTAATAAGTATACGATGTGTCAAAAATTTGGCCTAAACTGTCATGACGCTGCTATAGATTACGGTGATAGAAATTTGAATATGTATGAAATAAGTGAAAAAACAGTAGACTGAGCCTTACTCAAATTCACATCCGTTCGAGGGTCCATATTCCTGAGTTGTGAATTTCTGTTGGTTGCAATTGCCGTAACTTATAAGGAAATTGAACAATTTGGAATTTACAGCACAAAATTAGTTTGGTGCTTCTAGAGCCCATTTTATAAAATATATACTTGACACGTGGCACTAATAACAACATCTCAAGAAATTCAGGAACCACAATCGTTTCAGTCCGAAGAAGAGTGTGGCGATCGGCAGGCGTGCCGCAGCGAATGGATCGGGTGCTGCTCAACTCGAGTCGGGAAGATCGCCATCCTGGTCATGTCAATCATTGTATTATATCTTATCATATCAGGTTGGTTTAAATATATTACTCAAATTTATCTGAGTTTACAGGACAATGAATGGCTGTCAGCATTAACGCCCTCCGACTCACCACAGGCAGACGGACCTCAACGAGCCGCGGCCTGGTATTAATTTAACAAGGTGTGATTGGGATATTACTATTGTGGGAAATTGCTCGATAATTCCACACTTATTGAGTTCACAATTAATTTCTACTTTATTAACTGTGTTTTTGGTAAAGACACTTTTTCCCCTCCCAACGATAATTCTCCTAGATTTTTTATAAACTTACGACATACTTATGAAGCAACGACTTGATGCGCAAATCGCAAAAAAAAAACAGAAAAATAACTATTTTATGAATATTACCATTATCGTATGGTGTCGTCTGTTTTGTTGTTAGTTTTTTTTTACTCGAAATTTTCTTAAAACACCGAATTCCACATTGAATCAAATTTCTTAATAATTTATTAGACAATTGGCGACTTTACAGAGCCAATCTCGGCAAGTACTCACCGGATGTATTATGTGATGCCTATGAGCGAGCAGACGTTTCCGGAGACTATTGTAATCGACTTTGCTATGATCGAAACTGGAGTTACTTGTCACTGACTAGTTTACGAAGGGCGGAACAAGACTGTGGTCATAGTGAAAGATGGCGGATAGATTGCTGTCTATAAAAGCACCCAATGTTGATGGATCACTTCGACGAGCCGAAAGACATCTGACGGATGCCCAGAGTTCTCTGATCGAGTAGTAGATATGGTGAATGATGAGCTGAGATTCGGATGGCCGAAACACTATCGACGGAGCAACATTTAATGGGGACTGTGGCCGACACACTGTTACGGACCAGGGAGAAGCCATGTCGAAAGCGGATCGATCCTTGTGGGCTTTGTTCAAGCAGCCTGAATTCATCCTGTGCCGAGTGTTACCGTTGAGACGTGTCACGCCGAAGCTCTTTGGGACGTGTGAGTATCAGACTGAGTCACTGGTGGTGTTCAAGATGAAAGGGTATTATACGAATTTGAAGGTGGTTGGGGATTTTTTTTTAAATTGATTTTAAAAATAAAATTTTCGCTCAATCCAAATTTACAGGCAAAAATCTTGGTGCATGTCATGGGAACCCTGAAGCTCTTATACGAATTTCTCGACGAACCCCCAATGGTGTGTTCGATTTGATCTCGGGTTAGCAGCAGCTTATGTCCGAAAAGGTAGGTCCGCCTGTTTTTTTATTTGATTTTTTTTTCCGAAAGAACCTCCATTAATTATTCGAAACTTAATTTAAAAGTTATTATGAATGATTTTTTAAACAAATTTAAAAATTGATGATAATCCAACAGGCCGGAAACTCAAACTGTGAAAACTGTCCCGTAAAACTCCATATTTCTCAATTTTTCTGCAGATTCGTTCTAATGGACGGTGACATACACGAAATCGACTGACAATTGGATTCTCTCCTAAAAGGACGTCTGTGTGAAAGTGATAATGATTTAAGAGTAAAGTACTTGGAGACTGTGAGGCGAGATGCATTTCTAATATGGTGTGGTCGGCGAGGAGTAACGGGAATGGTAAGCTTGAAAGTTGTATGAAGTTTGGAAAAATTGTGAAAAATCAATAAAATCGGCAAAAATAACTAGCTTTTTTCCAGATGGCCGAACTTGTTTTGCATCGTCACCTGTGGAAAAAATTGCTAATAATGCAACAGCATCTTGATGTTTTAGTATTCATAAAAAAATAAATTCGACAAAAACCTTTTTGATTTTTCCAAAAATCAAAATCACATTCTGATGCTCAAATTGAATTTTCAAAAAAAAATATAGAAATTTCTTTTTTAATGCTCAACAAACGAACGAATGTCAAAAAAAAAAGAAGTGAATTTTCCGAATTTTTTCGCTTAAAGAAAAACTGAAAATTTGAGGAATTTCAGTCAGAAATATTTTTTTTTTGATTGAAAGGATTTTATTTTATAGAATTTAACTTCCACTATTAGAAATTACCTATTTACTTAGTAATAGGAAAGTTGTGAAAATGTTAGGAAAATTTTTTTCAACTGTACAATTTCCCGGACAGGCCTGTCGTTCCTTTTTTTCACAACGTAAAAGAAAAAATTAATTAAAAAGTTCAAACTCCTAGTATTTATACATTGATTTTGCTTTAAAACAAAGTTTTTCTTGATTTTTTTGTGTAAAAATTGCAAAAAAATCCAAATTTTGTAGGTCTTCAGCGATAAACTGGTCAACATTCGCTCGTTACAATGGTCCAAAAATAAAAAATATTTGGTCGCATGCCGGGATACAGTAGAAAACAACTGGACTCAACGAATTACGGTTAACAGGGTGGGAATCTGCCGGATGTTTAAAGGAATCTAGCTCTATTCTTTTTTTTTTTCTTCTACTCCATGTGTCAAAAAATCCCCATGTCTTATGATTTTCTGGTGCTTTTTTCCATATTTTGCTTTTTTTGTGTTCTGGTTCATTTTTCCATGGCTCACAGAGCCCGAAAGGAACTTAGGATTTTCAAATTTTTCGTTTTTTTCTCATAAGTCTGTCATCATTTTTTGCTCTGCATCATCATCGTCATCGTCAACTTCATCTTAAAGGTTTTATTAAGGGGTATTATTACACTTTCCTCGAAAAATTTTGACGAACGTATATGTATGCTTCCCCTGCACTGTCTCCTTGCATTTGTACCTTCATTGTTACGGGTTTCAAGTTTTAAAACTGTGAATTTATATCGAAGAATTTTAATTTAAAAAAAAACTTTGTTTCCTTTTATGAATTGTTACAGACAAATTTTTTCTCGGCTTGAAAACTGAAGAATCCTAACCCTGACTAAACTAACTATATGTGTTGGGTATCAGCGTGTATTGGTCCACCCACGACGTCATGGCTAAGAAGATCGTACAACGTGAACTCTATGAACTAACTCTTTATTCCTTAGTTTAGTACACGCTAATAAACTACTCGTCTTTTCCTCCTCGTCTCCGAATACACAACATTATGAAAAGAGTTTTTCTTAAGATAAGAAATGTTCTAAAAAATCGATGGCCGAGTTTCCTGTTTACGCGGGCGCAACAGTAAAAAAGTGTTAACACAAGTGAGAAAACTAGACGACATTTATTTTCAAATTTCACCCGATTTCAAAATGTCAACAAAAAAGTCACAAAATTTAAAATATGAACAATCAATATCCCGCTGGCGCTGACTCCTCCCCTTATCCGAACTGTTCGCAGAGATTTGCCGTCGGAAAGTCGTTCGGCGGCGGTAACAATTGTCAAATTGTTCACTACCTCCATTACGTGGTGAACCACGATCGATCAGGGATTTCAAGACGTAGGTTCGGGAAGTATGGTACCACGTGTAATTTGGCTAAAAAATGAGAGGAAATTGGGAAAGGTTTTGATTTTATTGATTGAAAAATTTCATGTGAAAGTGGAAAATTGATTGATAATTAAATTCAGAAGTTTTTTTTTTGAAAATTATTGATTTTTATTTTTGAGAAATCCACTCTTTTACTTATCGCTTTAACGAACGAAAAAACAATCAAATTTCGCGGGCTCTTAACTGCTTGTGCATCACTTGGAGCATCAACAGCTTGTTTAACATCTGCTTTCAGCCATAACCAGTGCAAATCCAGCAACACCCGAAATAATGGTGGATCCACCGGCTCCGCGACCGCCATAAGCTCCGCCCCTTTTGTGTTAAAGATCACTAATGGGCACTTTGACTACTCGCCTGATGCGTTTTCCAGGGCGAATGAAATTGGCGGGAGACGGTGGGAAACCGAAGAAAAAATTCGGAGGACCGGGAGTGGAACGTCCATTCGTTATTCCACAGAATTCCCGTCGATTCGGAGGATACTAGGCCACCAAGGCTGGAAGAATTTGAGATGGTGGACATAGAGTTTTTTTGGCGTGGCCGAGAAAATGTCTTCATATCCGAAAAAGTAAAAGCGATGGCCTAACAGAAATTTATGTGGCCACCATATAAACCGATTTGAACTGAATTCTGGCCTAAAAATGAAAGATTCGTCGTCCTAAAAATGTTTTTAATGATTGGGCCTAGAATTGAAAGGCATGTGATGGCCTCCAAATTTCAGGTGGGCACCTATATAGACTTTGGTTGATAGAAATTACACGTGGTCCAGATTATGAAATCACTGCGGTATAAAATCCAGGTCTAGGAAAACAATTTACTAAGACTGCCTACCAAATCATCCCCTGGCCTAATTCGTTTAAATTTTTGGTGACGACCTCGAACTTGTTCATTTTTATCAACTGCAGAAGCCTTGCTAGTCGACTGAGGACACCTTCTCACTTTTGGCGCTGGCCGAGTTTTCGAAGGTCGGCGACCAAAAATTTCCTTTAAAAAAGCAACTCACTATAAGTTAATGGTTAACGGTCGAAACGGCATTGCTGTCTGCATCGATAATCGATACATGAGTTGTTCCATCCTGCGGCGGTGCTCGATCCTCCATAGTAATCATCAGGATGCGTCGTGTCTGTGATCTTCGACACTAACCCAATCCGCCCACTTTTGACGTAAAATTTTTTTTACGTCGTTTGCCACAGAATTTCGGGTCGCCAAGCCAGCTTCTAGCCGCATAACTAAATTTGCCGACTTACATTCCAGATAATGATGGGTCGTATAACGTTGCGATTTCGTTGAAGACTTCATGTTATATTCGAAGCGGGCCATCCATCACGTTAAGTATTGCCTGAGCCACCGCTGAGCCCGAGGGAGGCGGCCGCAGACCCCGCACCCGTTTTTCAGCTTTGTGTAGATCACATTTTTTGAGTCCTGGACTATTCATTTGTATTTGTTGATGTCCTGAAGCCGGATGATCCCACCGTTGGCTTCGAACTATTTGGCGAGTTGCTCGGCGAGCCGACCTGTATAAAAGTCGGCGCCATGATGGGATCTGTGACTGAGTTTGCGAGCAGCCGGAATGTCTCTAGGAGCTTTTTGGACGCGGGTTTTTATCTGGTCTCCTGGTTGGAAGACACGCTGAGTTTCGGGGTAGATGAAGTTTTTCATGGTGGGCTCCGCGCGGATTTGGTTAGGTGCTCGTTTTGGTTGAGATGCTTTTGCAAGGTCATGGGTGACATTGGGTAGCCTGGAATTTTTTAGGATGGCCTAGAAACGCCATGAACCGATAACATAGTTACTTATTTTGTGACCTCGAAATTTTCATGATGGCTTAGAAATTTTATGATGACCTAGAATTTCTAGCTGACCTAGTAATTTTTTGATGTCTCGAAATTATTAGTAATGTAATAAACTACTCGTCTTCTCCTCCTATGCAAAAATTTGGGCCCATCTCCCTTCGTGGTGAGACCGATCGAGGCGAGACCTGCCCATCGTGGCGAGACCCATCGTGACGAGACCCATCGTGACGAGGCCTATCGTGGTGAGACCCATCGTGGCGAGACCCTACGTTGAGAAACCCATCGTGATGAGTCGACCCATCGCCATGGTGAGACACGCCGTGGTGAGACTTATTGTGATACTGTTAACGTACACAGTAATTGGAGAAACTTTTAAACTGATTTTTACAAAGAGTTCAACATTTAACTTACCAAGAGCTCAATCCGTTGCCTCGCTTTTTGTTGCGGGATTATTGTTCTGTTGCCTCCATTTCCGTTACCCCTGTTGTGTTGCCTTCGACCAGCGATGAATCCGTTGACCCCCCCCTTTTTCGTTGTCCCCGGGGAATATTAAATCGGTTGCCCCCGTTATCCGTTCCTAGGGCTTGTTGGCCGGTCTAAAAACGGCCACCAGAAAATTTATCAGAAATGTTCTACCGTTAGGAGTTTTTTAGCAGAAATATGCTACCGTCGCAGGAAAAGTGCCCACCTTCAGCCAAAACCCTAATCAATAGTTGGTTTCAACAACCCGAATGTCTCCACTCGTTCCATTTCCGAATCTCTCGAATCCGGAGGCCGTGAAGCTCTCCGGGCACCGCAATCGCCTTCCATATTCTCGACTGATTCCACGTTTGTCACGGTACATTTCCTCTGTTGCGCGGCGACGGGGCAATCTCCCAAGCATCGATTACCGTACACTCTTTTGTGTTCTGGAAGAATTTTAGAGGTTTATAAATCATTGATAATATTTATAGGCCACGGCACAAAGAAGTTTCTAAAGGACACACGCGCTCCTGGCATTTCCTCATAATAGATTTTGAAATGGAAGAGTGCCGAGTTAGCCCGTTTGGACTACGTCCGGGGTAAATTACGGAGGGCGTGCAGACTTGTTAATGGAGCGCGAGAAAAACGCTTGAAGGCCAGAAACCAACAAGGTGAGGCCACAATCATGATGTTTCCAAAAATGTTATTAATAGGAAGATCATTCTTTTGTCTTCCGAAATTTTTCTTCTTTGTTTTCCTGTATTTCGATTATTGACTTTTAGTTGAAGAATCAATACTAATTATCTTTTTTAATTATTGATGTTCCGCTCCAATTCGTGGCGAGACCAACAACTCACGCATTATAAATGTCATAAAATTTCCGCCGCCAATTCCGGCCGAATGTGTATCAATTGCACCGATACAGAAAAGTGCGGCGATTGCCGAATCCACCGCATGTCCGCCTTTCAGCAAAATATTCCGACCGATTTCTGAGCAAATTTCGTTGTCGGCGGCGACGGCCGCTTTCGAATATTTTCGAGTGGAGAAAGTGCTGGTCCAGGCCAACGGGGGAGGCGGGCATTGTGTCTGGAACCTTGCCGAGTTTTATTTTTATGACGGCCACGTAAAATCCAGCCATGAACCGACAGCGGACTATTCTTCCTTTCACCCTCGTGGCCTAGCTTTCTAACAAGCCGGCATTAGTAAATCGGAAAATACAATGAAGCGAATGCGAGTCCTTTGAGATTAACATCGTTCGATTACGAGAACCGTTAAGCCGACCGCCGCGCGGCCTAAAGTACGGATTTTCATGGGTTGCTCGGCCTCGATAAGCGGCTCAACTTCATCAAATGGTCGATATTCTGGCTGTAAATTATCATCGTCCGGAAACGTGTTGTAGTATTGAACAGGAGGTGGGTTACTGCTGAAAAGTCGAGTTTTGGGCGTCAAATTTGATGCATTGAGTGGCCTGATCACGATAATTACAAGATCGCGACATTTTAAGAAGGCGTATTGCACAACATTTTTCACGCGCAGAAATCTCGTAGCGAAAACTACAGAACTGTTTAAATCACGGTAAAGCTTGTGTCGATTTCCGCGGTTTCGGTTTTTTCATTTTTTTTTGTGTTTTTTAATTTAAAACAATTTATCGACTAATGAATGATTTCCGTAGAAATAGACACAAACACTACAGTCATTTAAAGAATTATTCGTAGTTTTTGCTCCTAGATATTTTGCGCTTCGAATATGTTGCGCAATACGCATTCTCAGAATTTTAGTGTTGCCATAATAATTCTAAATTTAAAAATGGAATTTTCAAAATCAGAGGTTTCCCAAAAATTTGAATATTCCACCAAGCATAAAGATGAATCTGAGAGTATTCAATTTTTTGAGCAAATAATCGATTTTCTGGATTAAAAAATTGCGTTGAATTTATAGATTTCTAGTAAAATTTGAATCTGTGCAATCTCAGACTAAAATGTATCGATTTTGATCGACTTTTCATAAAATTTAATTTAATTTTCGAAATTCCCAAAATATTGCCTGTTTTTCATCCCAAAAAAGTCGTATCAGTTTTTTCAACAAATTAGCGAAATTTTAATCGAAAGTTGTTTTCAGAGCATCATGATTTTTGAAAGAATTTGCAAATGTGAGAACTAAAGTACTCCCTTAAAGGCGCACGCTTGTTTTATTTTTAAAAAATTGGTCGTTTCGAGACCTGGTACCGTATATTCGCATTTGGGTAATATTCCCAGCATTATAAATTGTAAAAACAATGCACTTTTTAAATCTTGAATGCATATATTTATTTTTTTCAGAAACTCATGTCGCCTTCGGTCTCGATTCGAATTTATTCTCACAAACGTATAATATTTTCTCGAAAAACCCGCGAATTCTTGTAACATTATTGATTCTCACCGCGTAGATTGCCCTTCATCATTAATCAGAATTGAGTATGAATTAAAAAATCATAGAAAAGTCCAAGCGCTGTCTATTGGAATAGGACGAGAATGCCAAATTGCAACTTTGGCTTCAAGATAACGGAAAATCTTCTATCGCAAAACGCACTAGATAAGAGCTACAGTTTGCTGCGTGTAAGCGCCCTCCACGACAATGACAAACGAGAAGGGAAGAGAAGAGGGGGTAACCGCCAATAGCTCTCTGTATCGAGGATAGTCTTCAAGTGACAGAAGTGAGATATTCTGTGGGGAGAGAGTTGGGAGGAAGGGGGAACAGCGTATAAGGACTACGGAAGAGTGACTTGTAGATTTGGTGTATACGAGAAAGTGGAGGTTTTGGCTGAAAGTCTTTTATTTTCAAAAACTTTTACTTGTAACAACTAACGAGTAGATTTGACAATGAGGATAATATTCAACACAACAGAAAAAAAGTCGATGGGTAACTAATATAAATTAGAGAAAATGTGGCATCGGGGAGAAGTGGGAACAAAAGAAGAAACTGATGATGATGATAGGAGGATAGCCGCGAAACAAGCGATTAACAGAGAACAAGATTCATTTCGGTGAAGATAGAATAACAGCAAAAAAAAAAACAACAACAAAAGTCTAGGTCTTATTGCCCATTGAGAGCTATGCTGAAGGACACTGGTAAGGTGCTCGTCGATTACATCTTGCTGCGCGAATTGTGGGAACGATGCGTACATTCAGGATTGTGACAATTCTTTGCTTGGTTTGGTTGCCGCTATCGTCGTCGCGAGGTTGAAAGAGCCATCGTTGGTGATTGAGAGCAAGCCTGCAAAATACAAATAAATAAAATAAGTTACGGATTTTTTTAGATTAGAACTTACAAACAACGAAGATTCTCGGAAGATCTGATTTTCTGGTCCAAAAAGTGCGGCGTTTATCAAACAATTCGGCGAGACAGGTGTATATGTAGGGGCTTTCCTCGGTGTCTGAATATGGTGGCAACCAGCTCAGGAACAGCTCTACGACCTGGAAATAATATGGAACTTTTTTCTTAACTGAAGTTCTAAAAGCAACCTTTCCGTAGGAAGGTCTTCAGAAAGGCAGGAAGTGGCACATTGCGATTTTGGCTAATGCAGAAATCGCGTTTTCCGTGGCAATTTACAGTGCTCTCCTCGGTGGCGCGTCCTCTCGTTGAATCATGGCGGCCAGTGGCCCCAAACAGCCCAAAAACTCGTTTCGTGGTGGCTGATCTGGCGCTAGTTGATGGACATAACTCCGAAACCGTAGCTCGCTTCTGGTCTCACTTCAGGATACTCCTGATCTCCCAACAACATGTACATTATTGGGAAATAAGCTTCGGGAAGTGAATTGGGATATGTCCGTAACACCGAACTCGATGGCGTCATCGAGTCTCATGGCACATTCCCCACTTGTCTCTCCAAGTTGTTTGAATCCCTCGATGAGTTGAACGGCACATTTGAACATGTTGATCATTCCCTCGAAGATAGTTCGCTTGGACTCCTTCATAAGCTGAGAGAGAGTCAAAATCGATGGCCTCTCCAAGGCCTGAGGCCTCCATTATTCCATGAAATAATCGAAATGAGCTCCTCATTAGCTTTACAGCATTCCCTATTCATCGTCATCTTCATCTTCAACTGGACGATCGCTCATTCTCTTTAGTTTTCTGCTCGAGCAGCACCGAAATGATGAGTTGAAACTCTTCTAGATCTCGGCGATCCCCTCAGTTTTCATCCTCAATGAGCCGATGGTCGTCATGTACGAGGCGAGAATCTCGACATCGTCCTCCTCCTCCGACGTCAATGCCTTCAAGAACTCGCACCAACAAACGACGCTTGACAGCCAATCCTTGCCAACACAGGTCAACAAGCATGGCATGATTTCAGCGCCCGTACGGAAACTCCGTCGTGAAGCCCGAAATACATCCGAGATTCTTGATGGCGTGCTGGTAGTCGACGGCGTGTGGCATGAAAGCCTCTGGCCTTCATGTCCTTGGAAATCGAACGCGACAAGCATATCGCAAGCAGTTGCCTTTTCCTCAACACCTCTGGTGCGGATTCCGACAGTCTTTTCTCCTCCGATTCAGTGGTATTCAACTCACTTCCTCGTTTTCGTGAACATCTTCGTCTGAAATTTATATATTTTTTTAACACGTAAAACTAAAAAACACTCACTGTTGAATATATTGAATTCTAGGCGGTAACGAGCGGCAAGAAATGGATCCATGACACCTGGGAGGAATGGTGCGAAATCGGCTCCAAGAAAAGAGCAGAAACGAGTCCATGAGCTGATCATGTAGCTGTATTGTGGATCACCGATAGCCAAATCACGACTTCATGTCTCCGAGAAGGTTCAGGATCTCTTCGATTGCAGTAGGGTGGAATTGTTCCTTTCCGACAGCATATCCGATATGAGAGAGATGCATTCGATCGTCTTTCCTCTCAACTCCTTGAGCTCTCCGACGTTTTGAAGAATGTGAACGAGGTTCGGGATGAGGCGAGGCCATGATGTTCCTTGAAGAGCTCCTCGGCGGCTTCAGCGACGGAGGCGATGGGCAACGGTGACGATGTTCTCAACGACAACCTGTTATGTCTTGTCTCCGACACGAATTGAACAGAGCGGAACAGCATCATTTTCGAGTTTCTGAAGAATGAGTAATGGAAGCTATTGTCCAATGATTTTCACTCCTCAAAGTTGACAAGAACCGAAGCGGCATGAACAGACACGTGGAACATCGGTTCTCTAAACTCGACAAGAGCTGGGTATGACGGCGGCGTGGCACTTCTTCTGAAGAGTTGGAACGAAGTCAGAAGACATTTGTCCGATGGCGTTGCAAGCCTCGTATTGAACTCTTGGATGAGCTTGACGTAATTGGTGATATGAGCCATAATTTGCTCTATGTGCTGGTTCCACAGATCTCACCCTTAAGGCGGACAGGCGAAGAGCCGCGTGCTTCATCTTCCAGTCTTCGCTGGTCAATAGCTTCTCGACAAGTGGAAACACTGGGAGCACCACCTTTCCGTTGAGGCAGCAAGCAACACGGTAGATGACGCGCTTTCGGCGATGATTGGGATACTGAAAAATAATTTAATTGAAGAGAAAAACTAGAAATCTTAATCTTCATAGTCTTCTTCCTCTTCGATCTCGTTGAGCCACTCATTGAGCACATCGTCATCCATTTCGGTCATGCAGGAAAGAAGAGTCTCGAGTTGGTCCAAGAGTTCACTGCTGGTTACGCGTATTTCTTGAGTCCTTTTGGTGCGCCAAGTACGGGCAAATATACTTCGATGGCGTTCTGACGGACCATCTCGTCCTTTTCCTTGTATCCAGCATGAAATCTGAAAAAATTAAATTTTTAAATGGGGCCATTTATATTACTTACAGCAAGAGTGACTTGAAGAACCTCGGCTGAGACCATATGAGTGTTAAGGCATTTTGGCAGAGAAGAGGCGGGCTCGGCGAACTCTCCGAGTCGTCCATGTGTCCGCGTCGCTGGTTTCATCGCAAACTTGAAGGCTGAACATTGGAACAAGAGAGGTAGCCTGACACTTCTCCTCATCATTATCAACAGCGAAAGCGCTAACAGCACGGACGGCGGTGGCCCTTGATTTGCAAATCCGGTGTAAGCCATCAGCACTTTTCCAAGCTTTTTGGAAGGATCTCAATGGGCCAGCCTGTTTCCAAAAATTATTGAGGATCTGCGAAGAAGAAGCAGGGCTATGTAGTTTCCGGTAAGATCCTCTTCAAACCATGATCCATCAGCGGATCGAGGACTCCTCCCCATGTCATATCTCTCGTGCGATGAGGTTTGAAGCGATTTACGGCAGAGGTATCAAATCAGCAATCTTCTTCTTAACCGAGAGTTCGGCGTGAACTATGCAGCCATCTCGAGAACTCTGTCGAGAATGTGCTGTTCTGCTCGTTCTGCGCAGCGTTTCTCGCATCCCAGTCGCTGGCGAGAACTCGTCGCAACCAAAACTGATCTGGCCTGAAAATCGAAAATTCCTGGACTATATACGAATTGAGTGAACTAACATCAGAATTATTCGTGTGGTGGGTGTAGGCCTGGAAAAGTGCAGCTACTCTTCCTTGGTTGGTGTCCTTCAGACGCATCTTTTCATAGACTTCTTCAGCTTGTTTTCGGATATCATTGTCTGCTGACTGCAGTTCTGTTGAGCTCATGCGTGAAACCTTGATTGACGTCCATTGTAGGGCACCCTGAAAATCAGAATATGTGCTAAAAATCCCTCTTCACAATTGAGAAGGATACTAAAGGATGAAAGCTAGTCGGTTTTGCAGATTAACGCCAGACCGGGAATACGCGGAATCTCGATGAGCACTCGAAAATAGATTTTTACTATAAGAATTGTCATTTGCAACAAAACCTATCGTAAAATGTGAAAGATAGGCCAACAATTATTGATTTGGGACAAAAACGCCTCGAGTGCACGATTCTTAACGGAGCGCACTTGCTGCGTCACACGCACCTTAAACTGTACACGGCGGGAAGTTCCAGTTATTAAAAGGATTCCCGTGATTTTCACGACATTTACTGGTTTTTTCAGCGAGTTTTCGCATCTTTTCTGCGACAAGCGATGATTATTAATGTTTGGAATATATGATATGGTAGCGTGTTGCGATATAAAAAATCGATGGAATGAGTCCGCATCAAGAGAAACTAATATCTGCATAGATCGCACTGTTTGCAATTTTGGCTACATTGGCCAGTTCACTGACAAAAAAAGAAAAAAAAACGGCAACATGAAATCTCTAGTACCTATTCCAGGCAACCAGTGTCTGGCGACGATGGAGTGTAATTCTGAAAGACGCAGTATTGAAAAGAGTGTGTTTTTCGCTTTTTTTTTCAGACAGACGAGTCAAAAGAGTAAATACGTCTCAGTAGTACAAACAATGTGCGGCTGCGAAATCAGTAAAAATTAACGACTTGTGATACAAATTCCTCAAGGAATGAAGGAGAAAGTGTACTTATTTTTGAGACCCGAAGAGCTCGGGGGATGTACAATTGGGGGGATTACCAACTCGATTGGCCCCGCCCACAGAACCCGACGTGGCTTGCAATACGCCCATTTCTGCAACTGCCGCACGGTTTTAAAACTGTACTTTTCTCAATAGAGCGAGATTAAGAAGAAAAAATAATAAACCGTGCGGCAGTTGCGGACATGGGCGTATTTTGGGGCAAGCCACGGTTCTGTGGGCGGGGCCAAACTCCCGAATTGGTAATCCCCCCAATTGACATCCCCCTCTTCGGGTCTCCTGTTTTTTAATTTTGAATTGAAAAATTGTCCAAGCGCACACGTAGAACATCAAAACCAGTGGAGGGGCGAAATTTGATAGATCGCATGTGCAAGAATGAGCATTCTACGAGTTGAAGTCGCGCCACTGCTGCGTAATCGGGCGCGCACAATATTGTGCAATAAATCTCGGTTATTTGCGTACATGCATCATAGCTTAGACGCGCAAATCATATTAGAAATTTCCCCGAAACACGGGGAGGCAAAGCTAACGTGGCCGAAGAAATTGGGTCTACAGTAGTCCCATTTGGCTACTGAATATTCAACGCGAATAAGTTTTGTACACTATTGCGTACTTTGCGTACGGTAACGCATTTTATGCATTGACGACAATTCGTCAATTTCAGCTCAGCCTAAAAGCGCTTTTCGTCATTATGTGAGCGAATAAAAGTCGAAAAAAACTGTTGTTGTAGAGAAAGTAATTTAATAAATAAAAAAGTGCATGTTTTATGTTTCTCATTATGTTTCCACTGATTTTCTTAGAAAAACCGACAATTTCCTCGTTTTTCGAAGAATTTCCGCTGAATAGTTTGTTTTTATCTAGTTTTTCTTCCGATACTGAATAAGACATTTAATAACATCAAATATAACGTTAAAAACATTAATTGTCTCGAAAACCAATATAAAACTCGTCAGAGAGGGATACTTAGTAGATATGCTGAACAAGGAAAAGAGAGAGAAGAACATTAACCTGAGAGGGGGGAATAAGAAATCTGAACAGGAACGAAATAAGAACATTATTAGAAAGAACCATGGTTCCCTTGATCTTCTTGGCAGTCGTCTCCTTATCCTATCACTTCTTCTCGGCGTCCTTCTGATCACGCTACCGAGCAACGTGGCACGATCGAAGGGTTTCACAAGCACGGTTCGATACCGCTCCACGAGGGGGCTCCCAATTCAGCGAGCCATGGTCCTCTCACGAAGTTGAATTTTTTAAAATTAAAAAATAAGTAACGTCAAGAATTCCATCGAATTTGTGCTCCTTTGCAATAAGACAAATTTTTTTTAACGGACTTGAACAGGATCATTGACGGCATGAAAACGGCTTCCTCGTTGAACCATGTTGAAGCTCCTTCACCAATGCACCTGAAACAACTTCTAAATTTCAATTTAAAGAAAATCCACACACTTATCCGTCGGAAACGAATCCAATATTCTGGTTGCTGAGTGGAATTGCTTCAATTGATCTGTTTTTTTTTGAAATATTCGATCACACATCTTGTATCCACCAGATCGCTGAGTGCTTTATGATTCAGAGTCGCGCTTGCCAACCTCTTCCATCAGCACTTCTTCTGCTTGGAATTTTGATTGCTTTCGGACCGATTGACTTGTAGTTTCTTCTAATAGTCGCTGATTGAGCAGTCGACCTTGCAGTCCTACCGAGTTCTTTGGCTTCTCCTGCGGCACTTGAGCCCTTGTAAGAGCAGTTGAAATTGCTGCTTAACCTTCCTTATTAATAACTTCTTCTTGTTCGCATCTATTTCGAATTTTGTCTTGAAATCTTCCAAAGCAGCGACAACGTAATATCTGGAAATTATAAAAACATTAAAAATATTTTGAAAAAAAATCGAAAATGGCTGTATTCCTAAATTTTTTATTAAAAAAAAAAATGAGATACGTGAGTTATCATTGAGTTTTGAGAATTAAATCAGCATATATTTCTCCATATTTGAGTAGGTTATCAGAAATATTTACCATAATTTTTGGAAAAATGTAATTTTTAATTCGAAATTCGCACCGAATTTCGCGAATTTTTCACTAAAATCGAGAAAATAAATATGAAATACGCGTGTTTGAGGTTCAAGGCTTTTTAATTCGGAATCAGCATATATTTTTCGATATTTGAGTAGATTTTCAGAAATATTGTACCATAATTTTTCGAGATTGATAATTTTGAATAATAACTTACTCTACGATTTTGCCTTTGTCCGTTTCAATCCTCGAATTTCGAAGCGGTTTGCGTAGATTAGCTGAAATCATTATGCTTATCCCACGTAGTAACAAGGAAAAACAAGAAAAAATAAGCAAAAACGTGGAAAGAAAAATAATAGCATATCAGTCAAATTAAAAATGTTTATTCGATCAAAATTCTTAACCATAGGAGGCGGTGGACTCTAGCGGGCGCACTCTCGCGGCCACGTTAGCTTTTCCCCGTGGAAAGGAGCCATGATAACGGAAACACTATTTTCTGAGCACCCGAAATATATCGTAGCGAAAGCTACAGTAACCCTTTCAATGACTACTGTAGGGCTGGTGTCGATCTTTACGGGCGTTCATTTTTAAAATCATTTTTTTAATCTGTTTTTTGTGTGCGTCACTGTCGATGACTAAATTATAAATTAATTTCCGTAAATCGACATACAATCGCTACAGTAGGTTCATTTAAAGAATTACTAGTTGTTCGCTACGAGATATTTTGCGCGTCACTCCTTAGGTTCAGGCCACCAATTGTCTTACACTCAAAATCGACGTGAATTTCTGTGTATTTGACAGCAAAAGTGACGTGACAAACAATTAAATAAGGCAATTTGAAGAGTAAAAAACTGGGGAACGATGTGAGATAAGCCAAGAAGAAGCGGGGCTTCGACAACGTATACTAATCAGAGATGGAAAGTAAGAAATCAACTTGAAATTTAAGACAAAAAAGTCAACGGGGGATTTTTTTTAGAGAGAAGCGAGTAATCGGGCACAGCAGGCCAGAGAAATAAAAAGATAATAAACAATTGAAAAAATATATATATCGAAGGGGGAAATTATTGCTGAATAGACTGCAAAGAGGTGATCGGACGGTACAGATAAACGAAGTGTCTCTGGACAATTCCGGGTCCACGGACAAGAACGGCCTGCGCACAGTAGGCCTTGTGGTTGACGATGTTGGCAGCGACGGCCGGATGCTTGGGAGCGTAACTCAGACGACAGAATGGGTTCACAAATTCTCCCCGGCGTTGTACATTGAAGCTTGCTCTTCTTCTGCTGATAGGACGGCTTCGCGGAGGCTGAAGCAGCTTCCAGCGGCATTGCCACCTCGTATGACAAAATGTTCCGTATTGACCAGTGCAAAAAAAATTTTATGAGAAATTGAATTTAAAATGATTTTATTTGTAATTTACTTGTTTTGTTAATTGGTTCGATAATTGTTTTTTTTTTGGGAAAAAACCGAAAAAAAAATTAAAATCTTTCATTTTTCATTTAATTTTTTTGTTGAAAAATCGGCAGTTTTCGATTTTTTTTGAAAGAATAGGGAAAAGTCAGTAATTGTCGATTTTTCAAAAAACTGAAAATTCCAGATTTTGTCAGGACAAAAAACGAGGAATTCGACAATATTTCAATTTTATTTTTTTAAATTTGCGTTTCTCAAATTTTTTTTTGATATGTGATTTTTCCGTAACTTTTCTCTGGAAAAAAACCGACAAATTTGCAATTTTTCAATTTTTTCCAAAAAAATCTAAAAATAGAAAATTTTCGATTTTTCCTTTTCTGAAATATTTAAAGTAACTTCCTATTTTTTTTAAACGCGTATTAAAATTTAAAAAAAAAATCGGAGAAAAAAAATGAATCGAAAATACGATTTTCAATTTCCTTTGAAAAAAATAGAAAAAATCGTAGGAAAATTTTCGTTTTTCGATGTTTTTTCTGGTTAACCTAAATTTTTATTACTAACACAATGCTGTCGGCTAGCAAATTACCCATTCCAATGGCAATAACGATTCTCACCCGCTTTGTCGTTTGTTTCAGGCAAATCAATGCATACGACCTTCTCGATGAGCATTCCGAACATGCCATTCTGAATATTCTCACACGAGTGAACAAGATCCTGTGCACTCCGGGCGTTCGTAACTCGACACAAGAACACGACGAATAGCTTCATAAAGGTTTCGCCAACGATTGAACTCTTCGAATAAACATTGTATTGAGCACCAATGTTATCGCGGACCACATCCTCGGAGTGCTCGATGGACAGAATCGTCGCCGTCAACTGTAAACCGTACATTGATCCAAGGCTAGTTTTGGAACAAAAGCCGCCCACATGGCTCAAGATCAACCCAGAATTCTCCGAGACGACAACTCGCTGAGCATTCACAAGGATCACTTCGATAGAGAACCGATAGTGCCGCGGGAACTTCGCTGATCTCGCCCAAAGACGTTCGGATAGCAGAAACGGAAGAACGGTGAGAATTGATTCGATGAAGGAGTTTCTAGCGATACATGAAGACCGAGAACTCGCGTGATTTGGAGGGCATATCGGATCTTCCCCTCGCGGAAGATCACTTCGTTCACTGAATGAGTTGAGCAACCAGAGAGGCGCCGATTGTTCGGTTCTGGAACAGGAAATTCACTTGTTAAAAAATATAATATGTTCTTAAAGCTATCACTATTTTTTTGAATAAGAAAAAAAATCACAAAAACTGGAATACACGAAAAAGCAGACAGAAATGTTTTTTCCCGAATCAGTTCCATATTGCAATTTTTAATTTTTTTTTTTCAGAATTAGCGATTTCCTCTTTAAAAAAATTCAGAAGATTCTATTCGATTTTTTCGGAAAAAAACAGGTCGAAAAATTGAAAAAATTCCCAAAAAGTTTGGTGTTTTTTTTCAGTGAAAATCTTTCAATTTATCGGGGTTTGTTTCGACAAAAATAATAAAAACCAGATTAAAATTTTTCAGTTTTTAGTTTTCTTTTCAGAAACATTGAATTTTTTCAATCCGAAAAATTAAAGAAAGGTATATTTTTTGAAAACACAAAAACGGTGGAAAAGTGTTGGTTTTTTGTAAATTTTTGCGTTTTCCAGCAAAATTGCCAATTTTTCCGAAAATTTTCAGATCGAAAAAATATCGATGTTTATTCTCCGAGTTTCAGCGATTTTTTTTGCAGCAAAATTTCAGATACCAAATTTGACATTCAGTTATGTTCCAATTTATGAAAAAAAACTTGAGACCAAAGTGCGGCACGGAAAAATGGGCGCAGGTTGAGTGGTATTTTTCTCTCAAACTAGTCCTTGCCCTGGTGATCACCGTCTCAAAAGTGCGTGTGCAACGAACTCCGCCGGATTTTTCGTCGCCGACTCCTGGCAGACCAACTGGAGCTTGACCGCAATCGCGGCCGCATGCCGAATCGCGTCGTCATCGAGAATCACTGATCCTCAAAATCGCCTTGATATCATCAGCTACGGCGAGTTGCGCTTTGGCATCATTGTCGAACGCGGAGGTTATGAAGAATCGAGGAGACTGGAAGAGAGCCGCGAAGATTTTGTTGGAATCAGCGAGAAGGATCTTTTCAATAGCGTAAGCTGCGGTACTTGTGGAATCGGAGTATTCGAGCTGAGAAGCGCGTCCGCCGACTTGATCGCAATCGGTAAGGTGCTCTGGAGCTGTTTCCTGAAAGTGACCGCAAACTTCAGTGCATCAGCTTTAAGGATCGCAGTCTGATTGAGATCGGTGTTGAGGTGTGTCTTGTGTGATGAAAAAATGAAGTCGTTGATGTCCACCAGCGGGTTCGTCGACGTTACTCCACTCTTAGCAGTCTCCGTCTTCACCGCGATCGCCGTGATCAGCGAGTAGACAATGTCGATCTTGATCCAATCACCACTTGCAGGTTCTGCACTCCCCAGACATGGAAGCCGCCTCGAATCTTCCGACAGAGACCTCGCGCAAGATCGATGGCTCAACGGCGGAGTTCCTACATCGGTACCCTCGATGTCTTGCCGCTTAATATAATCCAGTGGATCAGCCTCGATCAGTTCCATATCCTGTTGACGAAGCAGAAGCTTCTGAACGCACACGTTCTCGAGAGTCTTCAGAACGCTTTCACCAGTGAAGTGTGTAGTACTGTCACTGGCTGACCATCGACAGCAATTCCAGCGCGGCGCACACCATAGTATCGTATCGAGTGTCGGGGCCGGTAGACTTGAGCAGATTCCAGACGGCAAGGAGGATGTCGGGCACGAACGGAGATCTCTCGTTGCGTCGCGAGTAGTGCGCGCAGATCTCACAGATCTCGTGCTTAAGCTCGTCCAGAGTTGTAGGTTCTCCCGAGTTGGAGGTCTGCGTCGGCGCAGTCGATTTGCACGAGATGCAAGAAATGTGGGCATCCAGTGAGACTCATTGATCCTCGAAGGCCTATTCCGGAATCCCTGTGAGCACAGAGAATGGTAGACTTTTGCAATAACTAAGACTCGGAGCCATTGGGCGATCACGTCGGCTCCGAGTTGATCCTTCCGCTGTCTCACCTCCATCATGTTCCGTAGCAACAGAGTAAGAGGCGATCTTGGGGCTGAAAAGGTTCTTTTCATTTGTAGCAAAATCTGGGGACAGGTTTTCGGTCCAAATTCGAGACTGACATTCAGATTTCTTCAATGGCTCACCTAAAAAATTTTGAAAATTTGTCCATTTTTATAGAACGAAAATTATCAATTTTCGCCAATAATTCCTCATTTCAGCGTTGCTTTAGTTATAATTTTTGACTAAAAAATCATAAAATGTTGAATTTTTCACGATTTTTCGGAAAAGGCCAGCTTTAGCTAGCTTACAATGTCTAATTTATTTTTTAGGGTCAAAGCGGACAAAAATTCACGACGGCTGCGACGATTGTAAAAAAGTGGCCCGAAAATAGGGGATTTCGATTAGCTGAGCCAAATTTTGAGCCAAGCAACTCACGCTCTGTAGACACTTCTGCGTTCAGCTCTTTCCAAAGCTCTGCTGACTTGGATTCGAAGCGGAATTTGCGGAAAATCTGCTCCATGCCAGCGGTAGGACACCAGGTGATCGAGATCCGCTCCGTTCAGGCATTTCGACAAATAACCAAATCTGGCCATTTTTAGGGAAAATCTCTCTGAGCGATGTGATACAGAGCATTGGACAGGATGCGTTCCTGAACACTGGATTTTGTATTGAACATCGCTTCGAGAAGCGTGCTTCTGAACTCTGGCTCCTTGTCTTCCGGGCCCATTTCTACCTCTGGTGCCGGGAAACAATTTCTAAATATTCACGGATTTATTCAAATTTTCCAACCCAATTTCTATTCACAAAATATTTCAAAGGGACAGCCGCGGCGATTCGGATCTGTGGAGCTTTGTTGCTGTTTGACCACCAGTTGAAGACTTTGAATGATATAGCGTGGATTTGAATGCAGCGAGCGGAGCGCTTCTTCTCTTGCGTATCGCAGCCTCCGGCTCCAGAGTCTGCTGGAGAGCTGCTTCCCGATTTGCTTCATCGGGCAAAATTACCTAGGGAAAAATAGCTGTTTTGGGGGTGAAATAGGGAAGAATTGGGTAAAGGACAAAGATAGTTTAGCTTAAAACTTGGAATCATATTCCGGTCAAATATTAAAGTTTTACGCAACTTTTCGCACCCGAATAAACTCGCTAAAATTCGCAAAAATAAGAATTTACAAAAGTGTGAAGTGTTTACAGCGCACCCGACCCGACGCGCAAATTTTCTTCAGTATGTTTCCATCGTTTTCACTGATTTTTACTGTTTTTTATCCTAGTTTTCCCTTGATTTTCTTCAAATTTTCCACTTTTTCAGAAACGTGTATTAAAAAATAAAGCGTTAAAACATTTCAATTCCTTCAAAACTTTGCAAAATAAAGGCGTCGTTGCGTACAATGCGCACGACTTGACGCGCAAACTTCCCAATTTTTAGTCTTAAATTTTCCTGGATACCACTGGTTTTTTCTCTGTTTCCCCCTTTTCGCATTTTCAGCAAACATGGGTGTTGATAAAAAGCAAAAGAATAACCAATCCATGCGAGTTAAATTTTAACAAATGCATAGCATGTCGTGAGTTTTTCAGAATTTTGACGAAAAAATCGATTTTGCTCGCAGATTCTCGGCCGGACTAAAAAGGGCGACAAGGAGCACCGACTGCGTCACGAAAACGAGCTCACGAGCAACGTGGACAGACGCTAGGCGTAGAAATGACCGGATAAGATTAGGAAAATTGTCGACAAACGGGTCGGCAGGGAAGCAAAGAGACGGTCTTGAAAAAGCGAGCAACGAGGAGAAGGGCGCGATTAGATTCACAGATGAAAGAGTCAAATGAATTAGAAAAGAGCATCGAAATTCAACTTGACAGATGATGGATATGAGGAGGAAGAAGGTTTATTCTAAATTGAGAAAAATTTTAATAAAGTAAATTTCAGCACTTACTCACAAGGGAAAAGCGCTCTCAGACATTGAAAAATACGACAAATGATTTCCGACTCGGAGATTGAAGAGGCAGGAAATTTGGGCTCAAATATCGTAAAAGTGGCTCTTTTCGGTGGTGGAGAGAAGACCGCCGAGGAGCAGTCCGCGAAAAAATCACCCGAGAGGATATGATTTCGAATTTCATTGCGAAAACGAAGCTGGCGCGTCACGAGAACAGCAGCGTGAAGGATGAGCTCGAGCTGATGACAGAGTCGTTGGATCCCAAGTATCAGGCATGGGCAAAATACCGGAGGCTTCATTTGGGCCGACCGGGCGCCAGCCGTTGACAGAAAAAGATGATTACGACACAAATTGTACGGGAAACATCCCGGTTTTCTCCCCGGCAAATTTTTAAGACAAAAGATAATTATAAATTTAGAGTGAAAATCGATTTTTTTCACAATTTATGAAAAGCTAAAACCCAAAAAACATGATCTGAAAATGCTAATTTCAATTTAACCATTTTTGCGATGGAAGATTAATCGGAAATTTTCATTAATTTTGCTGTAAAAGTTGAAGAAATCCAAGTTTTAGCTCTGTAATCAGAGAAAACACTGTCAAATTATTTCGGAATTTGTGCAATTAAGTGAAAAATAAAAGACATGTAACTAATCGCGAAAGAAATTGAGCTGAACTGAGAATTTTTTTGACGAAAAATCATTAAAAAGTCAATTTTTTTGACAAAAATTCGAGAAAAGTAGGTTTTTCTTTTCACAAAAATGACTGAAAAAGGCAATTTTTAATTTAAAAAAATAAACCCATTTTTCGCCTAAAAATAACTTTAAAGAAAGCCGTCGTTTTTTTACAAAATACAACAATTTAAAATAGCTATGTTTTCGACATAAAAATTAAGAAAAAGCCAATTTGTTTAAAAAATGATAGAAAACGGCTTATTTTTTGTTTCGTACGCCTAAAAAATCAAGCAAATTAGGTTTTATTCCATTTTATATCAAAAAATTATTATTTTTCCCGACAATCACCGTGATAACCGAAGCCGCTCGTGCCACCCCAGCAGATCGTACGCTATCCGAAGAATAATGGAGAAGCTCTGAAAGAAAAAGAACGTGACTCTCGAGGCCGCCCGTTCGATAATGCATTTTTCAACGCATCTGATTTATCATCGCCGATGCCGACGTTGATATCGGACATGCGTTGGATCGAAGGCCGACGCCAGAAAAGTTCAGACGGCGAAAAATGCCAGATTTGAGGTTTGACGATGAAGGTGGCCTGATCGATGAGGATACGGTGGAAAATTCCACGATTTTAAAGAAAAATCTGGATGGTTCTGTTGAATCTGAGGATGACGAGGATCTAGAAGATGAGGAAGAGGATCTGGATGATCTACTGGAAGATGATGATGAGCTGGAAGAGGTGAGATTCCGATGATGTGGAAAGTAAGCCCCAAAGGTCGGCAACATAGCGAAAAAATCTGCTTACCAGAACCCGCTGAACTCTGCCATTCGTATTCGAAATGCCGAAAAACTATACAAAATTCTGAGCTCTTCTGGAAACACAGGAATCGATGGCTATTTAGTGCTGCAACTCGACTCGTGAAATGTCATCATCCGAGCCTTAAAGAAAATAAGAAGCGTCTGAATAAGCTTTTCCTCTTGTGTTTAAGATGGTTTGATATGTGTCGAAGGAGGAATTGACAGCGGAAAGTGTGAAGGAAATGAATTTAGCGCAGGAAACTTATGGGAGGCATGCGTTGTGGTATGAAGGTAGCGATTGGGGCTGGAAAAGCTGAAAAATTACCGCACTTATTAATCTGAAAATTGAAAAAATTCCAGAATTTTTGACCTAACATTATGAAAAATTCCCGATTTTTAAACCCCAAAAATTGCAAAAAAGTCCCGATTTTTTACCAAAAAATGTTTTAAAATCCCCGAATTTTTTACCTAAAATTGAAAAGTTTCGCTATTTAGACCCAAAAATTGCAAAAAAGTCCCGATTTTTACCAAAAAATGTGTTATAATCCCCGACTTTTTGACCTAAAAAATGCAAAAAGTCTCGATTTTTAGACCCAAAAACTGCAAAAAAGTCCCGAATATTGTTACCAAAAAATGTTTTAAACCCCGAATTTTTGACCTAAAAATTGCAAAAAAGCCGGTTTTTTTACAAAGAAATGTTTCAAAATCCCCCGATTTTTTGACCGAAAAATTGCAAAAAAGTCTCGATTTTTAGACCAAAAATTGCAAAAAAGTCCCGAATTTTTTACGAAAAAATGTTTTTAAATCCCCGAATCAATTTTTTGACCTAAAAATTCTGCAAGATAAATTCCAAAAACTTTGGCCAAAAAATTAAAAAAAATACCCGAATGTTTGACCCAAAAATTGAAACAGAAAAAGCCCCGATTTTTTCAGAAAAATCATGTGAAAAAACCTTTTTGAAAATCAGTCTCGAAAAAAAAAAGAAAAACCAGGAAAATCCTGAAAATCAGAAAAAAATCATTAACAAAAACTAGGAAACGATCATGGAAATATTTTTAAAGAAACATTATATAAAAAATCATTAAAATTTCAGAAAAACAATATGGAAAATCCTGATAATAAAGAAAATAAAATGCTCTATTAAAAATTTAAAAAACCAAAAAATTCAACAATTGAAAAACTGCTAATTTCAAATTGTTTTTTGCATTTCGACATTCAATACGGAGTCCGATGTGTGCATGCTCTAATCTGTCAACACTGGAAGCTAGGCCGCCAGGACAACCAGAAGAGTAGCCCAGTGTTGGATTAATCTCTCAATTCGTCTTGTCTACGGCCTCTTCCCAGTTGCCGATTCCTGGCAGCCAGTAGTGGTTCCGGCTCTTTTTTCAACTGAAGCACTTTGCTCGGCGAAATGTGCCAATCTGACTGTGATGCGTTGGCTAAACAAATTCATAAGTTGGCTAATGCTATTCTTGGATTGTGTCTGAATCCAAGAGGTAATACTTGGAAACGAACATTTAAATAGGCAAATTTTGAAAAAAATACTGAAAGCTTTGATATAGAATAGGAAAAGAAACGAAAAAAAAAGCCAAAACCAAAACCCGCAAAAATATTAGTTTCAAAAACTAACGAACCTCAAACCCAAAATAAATTCAGAATTGTTGCTTAAAAAAATCGATTTTTCTCGATGAAAAAAGATCTATAAAAATTCAAAAAAGCAATTTTTTAAAATATAACTTGATTTTTATTTCTGAAGTTAATTTTTTAACAAGTAATTGCATTAACTTTCCATTTTAATGTTAAAAAAAAGCGAATTTTTCAAAAATTGATATTTGTTTTGGCAATTGTTAGATCAGAAAACATTGAAAAATACAAAAACCCCGTTTTGTTTTAAATTAATGGTTTTTTAGAAAAAATTGCAATTTTTCAAAAATCTTGGTCATTCTGTCTCTAATATTAAGTCTCCTCGTCTCTTTGAAAAAACTTTAAAAAACCTCCGAATTATCTAAGCGTATCAAAATTTTTGAAATTAAAAAAAAAACCGTACTCGACATTTTTACGAAAAGTTGAAAATTGTTTTAAATAAAATCAATTTCAGATACGTCCCCGAGCTGGTCTTGCTCGAAGTGCACTTCTGCTTGCAAGTTACAGAGAAAAGTGAGAAATTCGCGACAAATGGATTCCCGATTTCCAAGCCGCACACGGTGTTATGGAGGAGAAGGTAAATTTATAAAATTTGTTTTTTCAATAAAATGTTTTCTTTTGGTTTTCTTTAAGAAGATTTGCTTAAAAACGCTCAATATTTAAAAAACTGGCAAAATCGAATTTTATAATATAAATTAACAATTTTGTTCAAATAAAATTTTTTTTGAAAATTTATTTTTGAAATTTAAAATTTTGAGGAAATTTTCACAAAATTGCCAATGATAAAATGTTTACTTTTTCTTGTATAAAACTGCTTTTTTTTAAAAGCAATCCGAATAATTTTTTAATAGATTGCAGAAAAACCGAAAGACCTCCGTTTGAAAAACGAAAATCAGAGTCAGTTTTTTTCCGAATTTTCTATTTTTCAAATTAAATGTCGATTTTGCAAATACAAAACGGTTAAAAAAAAACTAAAAAAATTGCCGAGAGTCCAAAAAAATATTAGTTTATTTTGAACTTTTTTTTTTAGTAAACACGGCCGCCTTGGCAACGAAGGGGGAGGGATTGCTTGCGCGTTTCGCAATGCGCCTTACGCGTGCTGGCGCACTTCTGAAAGCCTTATTGAATTATTTTTGCGGAAAAAATTCATTTCTTCTATGAAATTTTCTTGAGAAAGCTAAGGAATGATGAAATTTTATAAAATAGTTTTCTCAGTTAAAAGGAGAATACCTTGCTGCAAGAGGTTAAATTTATTGAAAGAGAAAATAAGAAGTTTATCTTTGTTTTGACTACATAAAGTGGGGAAATCGCAAAAAAATTTGAAGACAATTAAGAAATATAATTAAATATTTAATTGCCCGAAAGTAAATAAGAAAGTTTGGTCACAAACAATTTTATTTTTGAATTAGGGAAGTGTTGAGAAATGAGCATGTGCCAGAATCACTAAATCTGAGACATTCAGCCCAATTTCTCTAATTTTCTTTGATTTTATCATGGAAGTGTGGCTTTTTCTGTGGTCTTGCCCGTTTTGTTGAAATTGGAAAATCCCTTGTGAACTGGGAAACTAGCAGTGAAGCTTCCATAAACAAGCCTTACTGCCGGAAAGGAAAGTAGACAATTGGAAAACTAAAACCGAAAGCAAGCATTAAGAAGATCCCGTTTTTATATATTTGATTTGCAAGCATTTTACAGTTTTTTCAAGAATTCAAACTTCTAGATTAAGTTGAGGCACAGAACTCTAAGATGGTAATACTAAGTTTTATGTTGAGAATAGCCAAGAAAGACTATCTGGAAAACATTGCTTTCAATCATTTTTTGTAAGTAATGTAATGTTGAAACTCTTAATAGTTCAGCACTTTGTATGGCTTCCTAATTTGACCCCGAACGTACAGTAGTATGTGGCAAGAAATAAAATATATTGTGCAAATTGGAGCCGAAAAACCCGACCATGATAAAATGTTAAATACGTGTATTGCTCTATTAAAATACCAAATATTAATTAGATTCACTGTCTCGGAACTCTTTTTAATTCAGATTAATTTTTAGCTCCTCTTTTTAACGTAAAATCTGGATTTATAGAGTTCGATCCTGATTTCAACAGGTACATAGACGAATTCTATCTTAAAATGACGAGAAAAGTTTGCTCTATAAACTTTGAGATCCAGGTTATGAGAAAAATAAATAAAAATTTAACTATTTTAAAAAAAAAAATCCGAAAATTCAGCTGTTATTTTCAAACAAATGGTTCGTTATGCATTTCCTCGACCGAACGATTTCCGAGAATTCTTGTTACTTTCGTTTCAGTCTACTTTATGAACACCTTGTTATCATTGATTGAAATAGTAACTAAATCGACGAGTAAAACTAGTAAAAATAGAGGGAAATCACTCTTCAACGGTTCTCGGTGGTGTCGACGCAATGAAGCTGCAGCAAAAAAATTTTGCAATTTCGGTCATTTCAGCTTCAAAAAGGTGTAAAACTTATTAAAAAATTAAATTTCATTTCAAAAAATTAATTAGTCATATGTGCTAAAAAATAAAAATTAGAAAAATTCTAATTTTCAGCGAAATTTCAAATTTATTTTTATTTCAGAAAAGGATTCAAATTTTGGCTTTCAAAACAGCTTACAAAATATTTATTTTTAAAAAATCTAAGAGCTTTCCCATTCTACGGGGGACCCGCACTCCAGCCACTCTCCCTGACCACAATAAACGCTTCAACAATTCCCCATCCGACCAATTACGACTCTATAGAGCTTCACGTTCATCGTGCTCTGCTCTCCCTCATAATCCAACATCTCCGTTTAATCTACGCCAACCAAAATGACTATTCTATCGTTTTCAAGTCATTCCTCCGGATTTTGGAATCAATTCAAGCCAAAAATCTTCAGCCGAGGTCCAGGACTGAGAGCTGGAGACTCTGTGCGTCTCAATGAAGGCTGAAAATGGAGCCGTGCCGTTTCTGGTGCACCTATCGCTGGTGAAAACCGCAAAGAGCATGCTGAAATGCTGGAACCTCGACTGCGTGGGATTTCGATCCGGAACGCCCCCATCACGTACCCAACAAACGAGAAGAAGAACGCTGACGAAGACTCTGAGGAACGAAAGACGTGGAGCCATTACTCAAGGAGAGCTGCTCAGAAAAGGATACTTGGGGCATTCGTGGCCAGGAAGCAATTGTCGAGTGCCAAGACGCTAAGGATCGAGCGAGAATTGCTGTGGCCACGAAACGTGTCATGGGCGGTCTTATGCAGGACAGCATGGGCGAGTGGATTAAGGAGAAGCGTACGGCGGATGTTGAGATTAGAAGAATAAGGATACTTGAAGAATTAATTTAAATTTTCCTATTTTTTGTTTGTTGAGAATGACTTTGGTATCTGGCAAAAAAAACCACTAAATTTCAGTTTTTCTCGATTTGTTGAAAAATACTCATAAAACTGATTTCTATGTTATTTTTGGCAAAATTTGCCTTTCCCCATTCAAACATTTTTTTTGCCATTTTTCCTCCATTATTTTTTTGTTATTTTCTTTTTTTTTCGTTTTTGTTATGAGATATGTTTCTGTTCTGTTGCCATTTTTTATTATTGAAAATTAAACGAGTTTCCTGAATTTTTTTGTTAACCCAATTTTTTTGAAATTTTCCGTTTCACATACGTTTGTCAACCTATCTCGATTAATTTTTGAAGTTTTCCAATTGACTCGCGCATTTTTTAAAAAGTTTTTAAACTGTACATTGACAATTACACCCCTCTAACTCGATCTGATTTTATTCAGATTTTTAGTTTTTTTAGGTGAAAAAGTTCTTGTGCTAAATTCATCCATTATAGTTCGTAATTCAGCAAATTTTGGGTCCGATTAAACTTTGAGCGATTTCCAATTTCATGGGAGTTTCTTGTTCAGAATATGTCTCGAAATTTTCTCATTTCTGGAAATTTTGAGTCTGTCACACAGTGTTCCGTAATTAGCTCGATTTCACTTACATCTCCTCAACTCTGCAAACTCTCAAACTTTCGGAAGGGTCTCGCCATGAAATCACGGGTGGGCGGAATTGCAGTTCGGCAAAGTGCCGGTTTGCCACGGATATTGTCAATCCCGGATTCCGTTTGCCGGAAGTTTTTAAACGGGATCTTTTATAAGACAGACGGAAAGACTTAAAACTGATTTTTAATTTTTTGCCCGTTTTCTCTAAATATTTTCATAGAATTTACTGACTTTTTAGGATAGATGTTTTCATGGGATGTGCACATGTTGTTCCGGCAAATCGGTAACTGCCGAAAAAAAACGACAATCCAAAAAAATCGTTTGCCGTTCTGTATTGTACCCTTTTTGGCGAATGTGCGTAAATTTATATGTGCTTGCGTGTGTAATATTACGTTCATATATTCTAAATATCCGCACCTTTTGAATTACTCATAATCTATGCATTTACGTACCGCGAATATATTTTGGGAATACACATTTATCATCATTCCCACCCGTTGCCATAGTATCCTCATCCCCGCCCCGCCCCGCCCCTTTCTCTCTTTCCTCTTCCAAATCCTTAATGGCTCATCCGGTCATTGGAGAGAGAGATATGGCAGATGTGGCGGTTTTGCCTAAGCAAATGCTCTGGAAAACTCGTATTTTATATAACTATGTAGACAATTTCGATATTAAAAACATTTATATGTAAAATTTTCATTTTTATATGTTGAATTTGCTCGCCGAATTTTGACTTACATTCTGACAATTGTGTGTATTTAAGAGGGTTATGTATATTTACGATATATTTTTAATCAGTTATCGAATGCTCATTTCCGTTTTTCTACGAGTTGTCTTCATTTTCGGTGGTTTTTTTTTGTTTTTTTTTTTTGAAAGTGTATTTTTTAAGTTCAAAAAACTACAAAAATGTTTTCAGTCAGGATCAATTTATTAGGTTTTTTCAATATTAAAAAAGTTATTGGGAAAAATGAAGTGAAACTCGTCGAAAAACGAAAATCATCATTCGATAAAGATTAAATATTTAGTAAATTGACACACATGTAAGTCTCCGCCGCGAAAAATCGATAAATTTCATAGAGGCATAAAAATTCACAATATAGTTTTTTTATTTTTTATTTTAATCCAAATCCCTATGCATGCTTAGTGCGAATTTTTAGCTGTTTTCTGTAAAAAATCAAAATATTGTATATTACATATCATAAATTTTTCCCATTTTCTCAAACGGATCTCGCCACGACAATATTAAAAAATTCCCGTACTTTTCTCCCGCAGGAATGCCGACAACGGAAGAAGCTGCCAAATCGCCGCTTTTCCGACGCAATCGACAATAATGACACTGAAGCAGCGCTGGCACTGCTGAAAACGAAGGAACAGGCCGCTCACGGGATAGTGGAATGAGTGCCTGCTGGCAGCTACTTGCCGCGTATAGGTATGCACTTTAAAGCGGCGACGGTTACTTTGGATCCTCGCAGATTGTTTAAAGGTACATACCGTAATCCATTGAATTTCAGAGGAAATCTTACGTTGGTCGAGAAAGCGATTGAGCTGAAATGTGAATGAGAAAACCGATGGAACTCTGTACACTCCACTCATGTTTGCCGCCAGGTAGGCAAAAATTTTTTAAAAAAATTCCGGATTTTGCGTCAAATTTGATGCAAATTCTGGTTTTTTTTCCGATGATTAAAGTAAAAAAAAATTCCGAAAAAAATCGGATTTTTATGCTAACAACTAACTTTTAAATGAAAAATCGTGGAAAATTACAAATCACGTAGTTTTGATCTCAAATTCAATTTAACGAAAAGTCAAATTTTATGGTTTTCGCGGTGACCAATATTCGCCAATTTTTTTTTGCCCCAAATACAACACATTTGACGCGCAATTTCATTTGAAACTTTTTCCCGTTTTTACACTCTTTTTAGACTGAACCCCAATATTTGAAGGCGTAAAAAAACAAATAGGACCAATACACTATATCTTACGCGCAAATGTTAAATTTTTATTTAAAATCCTCGTAAAGTTCTATGTTTCTTTTTTTGATCGTTTTCAAGCTCAAATCAAGTTTCAATCCGAAATATTACCGGAACATAATAAATGCGTACTGGTCAACATATTTGACGCGCAAAATATCTCGCGTACAGTAATTCATTAAATGACTACGGTAACGCTTGTGTCGATTTACGGGCTCGTTATTAAAAATCATTTTTCAAAAAAATCGAGCCCGTAAATCACCACAAGCGCTACCGTAGTCATATAATGAATTTTACCACTGTAGTTTTCTATAGGCGAGATATTTTGCGCGTCAAATATAATACACAATCTCAGGACTAATTTTGCGTTAACGTATTACTCTACTTTCTTAGTTTTTCCAAAAAAAAAATTCGAATACACCATATTTAGACGCGCAAACTTTTTTTTACGTTCAAAGCAAAATTGTCAAACGTTTGCAGGAAAACAGGCACGTATGCCGCCTGAATGGACTCCGCAGCCCGTATGTATTTGGTGAATGGAATCGGAAAAACCGCCTCTGAACTGGCGGAGGCATTTGTGGGTCATCACGAGTGTGTGGCAATTATCAATAATCATATAACAATTGATGTGATCGAAGATCTTTTGCGGCCAAAAGTGAATGGAAAATATTATCGAATGAGCTGAGGAATAATGAGCTGGCTGTATTTATTCATTCCTTGTGTGGATCACATGAGATTCATCCTGTTAAAATTATTTTTCGATTCAGTAAATATCCAGCAATTCGTTGAAGTACAAGAAAAAGGTACATAGCTGTGTAGTTTGGAAAAAAAATGAAAAATCTGAAAATTTGAGAAATTTCCTTAAGCTTTTTCAAGATGCGCATTTTTGTTCATTTTTATTTTCAAAAGAAATCCAAAAAGTTTGTTAAAAAATTTAATGAGCATTCTTTTTAATTTCAAAACAAAAAAGTTATACCAAATAAAAACTTTTAGTAATCAAAATTTTTTTTCTCGGTTTTTCTCATCGTTTTTCAAATTTGAGATCTCTTCCCGAATTTTGCCTAAAAATTGATTTTTTCAAAATAAGAACTGATTCTGTGAAAAAATGTATGAAAATGCGAATCGCAAATATTCGAAACTAAAAAAACTTTTATTAAAATAAATTTTTGAAATTTTTCAGAATTTAAAAATTGAATCGAATTAGGTCTCAGTTCAGATCACGATTTTTTCGAAGTTCTGAATCTGTTAAAAACGAGAAATTAAAAAAAAATTTGATGTTAAATGTTTTTCGAGATTAAAACCGAATTGACAACCCAAAGAAAGTGTATCATGTAAAATGTTTTTGTTATAATAAACCAGAATTTTCTCGAAATTTTCAGAAAGTTCTAGAATATTTCAGAATTTTAGGCTCTCGAAATTTCCAAAAGGTTCTAGAACATTTTCAGAATTTTCTCGAGATTCATTTTTCAGAGGGTTCTAGAACATTCCAGAATTTTCTCGAAATTTTGGTTAGAAGATAGTAGTTCAGAATTTTCTCGAAATTACCAAAAGGTTCTAGAACAGTACATAATTTTCTCTGAAATTTCCAGAAGGTTCTAGAACATGCCAGAATTTTCTCGAAATTTTCAGAAGGTTTTAGTATATTTCAGAATTTTCTCGAAATTTCCAATCGTAAAGGTTCTAGAACATTTCAGAATTTTCACGATTTTCAGAAGGTTTTAGAATATTTCAGTAGCAATTTTCTCGAAATTTCCAAAAGGTTCTCAGAACATTACAGAATTTTCTCGAAATTTCCAAAAGGTTCTAGAACATTACAGAAATTTCTCGAAATTTTTAGAAGGGTTCTAGAATATCTCAGAGTTTTCTCGAAATCTCCAAAAGGTTCTAGAACAATCCAGAATAATGTTTTCAAAAAATTCAAATTTGTCCCGCCAAAATGTTTGCAAGAAATTAAACTTCGAATTGCCAAAATATGTACAGTACTCCTACAGTACCTCTACAGTACTACTACGGTACACCGAACGTCCCATATCCCACTACTAACCTAACCTATATCTCTTCAAAAGACTAGAACACAATTTTTCCTAAACTACAGTAATCCTACCGTACTCCTAAAGTACTACTACAGTACCCCCACCATACTCCACTGCTAACCCCAAACCTATATAATCATCAAAAAAACACAATTTTTCCTAAACTAGAGTAATCCTACCGTACTCCTACAGTACTGCCCTACGGTACTACTACAGTACCCCCACCATATCCCACTACTAAGCCCAAACTAATATCCTCCATCAGCCAAAAATGCCTTGCCCCAAGTTTGTAAACAATGAGGTCTCTAGTTGATTAACAAACGGACACTATTTTTTTATTTTTTTCAAAGCAAAAACCATCCATTTTCCAGATCCTCTATGTCATGGGTATCGTGTCTTCGAGAAACAGCTTCGATGTAGGGCAAGCAATGAAATAATGTCGCTCAAGCTTTGGCTAATTCTATTTTCAAGGCGTGAAACCTCGAAATTTGTGGAGTCGAACAAGGAAAAGTCGCCAGTAGTACAACCAGGTACGCAAAACTGAGTTCCACGTGGCAAGAGGTTGGCGATGAAACTAGGCGAGCACATGAACCCGCGTGATGAGAAATACGGTTGCATGCGTACGTTCCCTAACAGTATAAACATTCATTACTTCATGATACTCTACAAAAAGCACTGCAAAAAAGTCAAATTGGTGCGAACGATACACCCAATGTGCCACGTATGAATACATTGTTCAGGCACTTTTCCGACAACGAATCGCTGCCGTCTGCCCGTTTTGCTCGGGGGTCTTTGCGGACATCGGAGCCAAGAAACGGTGCTCACAGTGCAAGTAGGGAGTTTTGTGCTAGGGTTAAAAATAATTATTTAATAATTTAATAAAGCTCGAATTTGTGGAAATAATCAATCTCCAAATTTTAAAAATATGTAAAAAATTTTATTCCGTTATATGCTATTTTATAAATTTTCCCACAAACTCGGCATTTGGCTCTAGCTTCTTGCTTTAGCCCAAATAATATTAACTTGAAGCTGTCTAAACACGTTGGGAAAAGTTAGACAAAGACTTTGGCAAAACTTGGATTCAGCTTTACCAAGGTCTAACCCAAGTTTCACCCAACTCTTGCCAAACTTTGGCCCAAAGTTTTCTTATTTCGTTTCAAATTTGGGCCAAAGTTAGGGAAGAGTTGGGTGAAACTTGGGTTAGACTTTGGTATAGCGTGAAGCCACGTTAAAGTCTTGCCTAACTTCCCAAGTTTAGACAGCTTCTGATCCAAGTTAACATTTTTTGGGCTAAACTTGGGTAAGAAGCAAGAGCCAAATGCCGAGGAAATCCCGCCGAAAATTGAAAGTTCAAAATTTCAGCTTCGTTTTTAATTATTCTGCAAAATTTGGAAGTTCCAACAATTGTTTAAAGATTCTTTAAATTAAAAAAAAGAATTATTAAAACTTTTTAAACACCAAAATTCATTGTAGAAAATTCCGAGCGTAAAATACTCTTTGAAAATCCGGGATAAAATCAAAAAAAAAATAAATTCTAGACATTCTGCCATTAAATATCGAAAAAAGAACATGTTGTCTGTAAATGTATTAGTCAAAATTAATTCTGTTTTTCCAATCAAAATTTTAAGTGTCTGTAGAGACTTATTTGAGTTTCCTGTTTTTCCTCGTATTACTAAAGTTTTCTATAATATGCTGTGTTTGAAAATTAACTATATGTGAAAATATCGAGGCACAACGTTTTCAAGATCTGGTGAAATTTCGGATCTACGTTTTTCGGATCTACCATTTCCGGATCTACGTCTACCGGATCTGGCACCGTGCCAACGCGCAAAACGCTTTTTTGATCACTCGGCGCACGTTGTTTTTTGTAAATTTCTTCTAGAAGAAACGCTTAACCACACGCGACGCGTAACAACGGAGCATCGTTATCACGTTTTTCTCCGAGATTAAAATCTTCGAGCGTTTTATCAAGAGTCACGGTGCAAGACGAAAATGGTAGATACCTCGGGAAAACGGAGATCCGGAATTCCGCCAGATCTTGAGTGGTGCCTCAAAATATCGATTAATGAATTTTTTCCGAAAACCAATTTAGCTTCAACAACAGAATAGCTAAAAAGTGATCAAGAAAAACTCAATTCTTATAAATTGCAAACACTTTCCAAATTTTGATAAAATGGAAAAGATTTTAAAAATTTCAGGCAACACATTTTTTAACTCTAATAAACGTTTTTTAAATTCCAACAATTTTTACAGCTCGCCTACTGTTCCCAAAAAGAATGCCAAAAATGCGACTGGCCAATTCATCTCAAAAAAGTGTGCTCATTTCTGAAGAATTAACGCTACAAGAAGTGTCGCCCACCGACGAGACCGCCATGGCGCTGGACTCGGCTCAAATCGTGGCGCCAAAATCGAAGTGTAGAAGTGCCGATATTCGATCTCAATATACTTTTTTTCTGGTAAATTTATTTATTTTTATATTTCGGCTTCATCTCATTTCACGCAATTTTAATTTCATTTTCATAGATTCATTTTTGAAGTCATTCCTTGAACAGGAAAATTCACTAAAACATGCATTAAGAAATATGGAATCCAAAAATTAATCTAAAAACCTTTTCAAAAAACCACTTCGTCAAAAACTGATGATGGAAAACTCGTTGACAAAAACGGAAAGAGTATCCAATAAAGATTAAAAAGTTCGACATTTCGTAAATCGACACAAATCTCGTCGACAAAATCAATACCGAAAAAATCAGGAACCCAAGAAATTCAATATTCCCATTTGTAAAGACAACTCGTAAAACATTTTCAAATCAAGAAATTATTTTTTTTGCCCTCAAAATTGATCCTGAGTGAATACTATAAAAAAGAAAACTATAAAAAGTGGCGAAAATTCGAAATTTTAGCCCCTCTAAATTGGTTCACTTTAGTTGTCTAATGATACAACAAAGTAGACATAGGTTACAATATCTGATATTGGACTTGTCTAAACAAAAGTGTTTTCGTTTTTTTAACGGATTTTTAAAATCCAGAAGAGTAACGAAAAAAAATTATTTTAAGAGAATAGAGTAAACTATAATCATGTTCGAGAATCAAATCCGCCTAAGAATATGAGGTACGGACCCAAGTGTATCATAATTATTTAATTTCTGTGTATCAGAATTATTTTAGTTTCCTTACTGTGATAGGTTCCCAAACTGCTTAAATTTAGGAAATATTTCTTTACTGGACACTCTTAGCCACTGTACGCTGCCGATCCCAACGCATAATAAGAGAATACAGAACACCAATTATGCCCGAGAAAAAGATACTCAGAATATAAATATAATTTATCGGATGGATCGGCAAACATTGAAGACACTTTCTAATTACCCAAATTGTTCAGTATATTCTAAATCTAATTCTCTTAAACTAGAACCCTCTTGGCCAATGTACGCGGACGAACGTATCATAAGTAAATACAGAACACCAATTATGCCCGAGAAAAAGATTAGCACTCAATAAACATTAGTCAAATTCGGATGTATAATGATTCCCGAAGACACTTTCCAACCCACATTGTTCATATTCTAAATGAAATTCTTTTACTAGAATTGTCCAATGTGTGCTCCGAACGTATCATAAGGTGAATACAGAACAACAATTATGCCCGAGAAAAAGATCACTCAGAAAATAAACATAGTTGAATTTATTGGATGTATAAAGATTCCCGAAGACACTTTCCAATTACCCAAATTGTTCATATTCTAAATGAAATTCTCATACTAGAACACTCTTGGCATGTACGCAGCCGAAGGTATCATAAGTGAATACCAGAACACCAATATATGCCCGAGAAAAAGATCCTACTCAGAATATAAACATAGTCGAATTTATCGGATGTATAAAGATTCCCGAAGACAGTTTCGAATTACCCTAATTGTTCATATACTAAATGACAATTCGCTTACTAGAACACTCTTGCCAATGTACGCAGGCGAACGTATGTGAATACAGAACACTAATTATGCCCGAGTAATCCTACTCAGAATATAAACATAGTTAAATTTTGGATGTATAAAGATTCCCGAAGGCACTCTCCAATTTACCCAAATTGCTCATATTCTAAATGAAATTCTCTTACCACTCTTGGCCAATGTGCGTGACGCGGCCGAACGTCTTTTATGATAAGTGAATACAGAACACCAATTATGCCGAGAAAAAGATCCTACTCAGAATATCAATTAAACATATTCAAATTCAGCGGATGCATAAGGATTCCCGACTCTTTCCATACCCAAATCATTCTAATTGAAATATCTCTTACTAGAACACTCTTTATTGGCCTATGTACGCAGCCGATAACGTATCATAAGTGAATACAGAACACCAATTATGCCCGAGAAAAAGATCCTGCTCAGAATATAAACATATTCGAATTTAACGGATGTATGATTCCCGAAGACACTCAATTACCCTAAATTGTTCATATTTTAAATGAATCTTACTAGAACATTCTTGGGCCAATGTACGCATTGCCGAACGTATCATAAGTGAAAACAGTACACCAATTATGCCCGGGAAAAGATCCTACGCAGAATACAAACTTATTCGAATTTATCGGATGTATAAAACAAGGATTCCCGAATACACTTTCCAATTACTCAAATTGTTATTCTAAATGAAATTCTCTTACTAGAACACTCGGCTTGGCCAATGTACGGAGCCGAACATAAGTGAATACAGAACACCAATTATGCCCGAGAAAAAGATCCTACTCAGAATATAAACATAGTAAAATTCTGATGTATAAAGATTCCCGAAGACACTTTCCAATTACCCAAATTGTTCATATTCTAAATGAAATTCTCTTACTTGTCTAGAACACTCTTGGCCAATGTACGCTGCCTAACGTAACATAAATGAATACAGAACCCCAGTTATGCCCTAGAAAAAGATCCAACTCAGAATAAAAACATATTAGAATTTACCGGATGTATAAAGATTCCCGAAGACACTTGCCTTTCCAATTAACCAACTTGTTATTCTGACTGAAATTCTCTTACTAGAACACTCTTGGCCAATGTACGCAGCCGAACGTATCATAAGTGAATACAACAAGAACACCAATTATGACCCGAGAAAAAGAGCTTACGCAGAATATAAACATAGTCGAATTTATCGAATGTGATTCCCGAAGACACTTAATTACCCAAATTGTTCATATTCCAAATGAAATTCTCTTACTAGAACACTCTTGGCCAAGCAGCCGAACGTATCATAAGTAAGGAATACCGAACACCGATTACGCCCGAGAAATAGATCCTACTCACTCGAATATAAACATATTCGAATTTAACGGATGTATAAAGTCCCGAAGCACACTTTCCAATTACCAAAATTGTTCATATTCAAAATGAAATTCTCTTACTAGCACTCTTGGCCAATGTACGCAGACGTATCATAAGTGAATACAGAACACCAAATATGCCCGGGAGATAGATCCTACTCAGAATACAAACATATTCGAATTTATCGGATGTATAATGATTCCCGAAGACACTTTCTTACCCAAATTGTTAATCTTCTAAATGAAATTCTCTTACTCGCACACTGCCAATGTACGCAGCCGAACGTATCATAAGTGAATAACAACAATTTACCCGAGAAAAAGATCCAACTCAGAGTATACACATATTCGAATTTGATCAATCGGATGTATAAAGATTCCCGAAGACACTTTCCAATTAACCCAAATTGTGCATATTCTAAATGAAATTCTCTTACTAGAACACTCTTAGCCAATGTACGCAGCCGAACGTATCATAAGTGATTACAGAACACTAATCATGATCGAGCAAAAAGATCAGATCCAGAATATAAACGTATTCGAATTTATAGGATGTATAAAGATTCCCTATTGGGAAGTCGAGCAATCCACGGCTGGTTTATCGGCCACAGTCCGCGGTTAGGACATGGCTTATATTATTGGGCCAAGCGGAGCACCACCAGGCTGTGTACCTGACTTCCAGATCAGCAGTACATAGCACTAAGAAAGGATCGTCCTTTATATCTTTTAACCTTTTAAAAAGAATCGAAGGAACTCTCAGGGTCATGTGGTTCTGGGGACAAAGAGGGAGGCTTACATCAATACCAAACACTGGTAGATAACAATACCTGTGGTAGATCACAAGCCACCCTAGCCACAAAGAAAATCTGTGGACGTCCTCAAAGGAGGCCGCCGGCGCCCTTGAGCTGGCCAACAAACCCTTCGAGCAGGGTGGAGGACTACTCCAGCGACTGAAAACGGCGGTATTAACGCCACGTTGTCGCCCAATAACAAAAAGCCCTCGGGAGAACCTCAAGAAGCCCACGGCTTAATTTTCAAATCAATTACCTTACTATGAATCTCCTTTTGGCTCTACGAGTCGTCGTTGATGTTACCATCCATTCCGTCCTACCTGGGTCCCGTCAAACAGTCCATCTGACGTCCAACCAACATGGGTGGAGTGTCCAACGCATCTGAAATTGAAAAGTATTTATATCCACTGATTTTTTAAATGGAACCATTTACAAACAAAAACGGAAACGCTTAGGTAACCAAAAAAAAAAACAATTAGTATTTAAAACAACGGAGACAAATGCTCTCGCGTAAGTTATATTAATTTTCCAGTCGACTGCAAGGCATCTGCTCCCACGGGTTTATATAAAATTATGTACCTATTTTTCTTGAAGTCGACTTGTCTTGAAATCTTTCAATCAGTACTTTTCAAGAGTTTTTGGTAATTTTGTCCGTCGATTTTTCAGAAATTTCAAAAAAACGGCGAAATTCCAGTCAGAAGCCTCATTAATATATCACTAGTCCAGCTCGCTGACCCAAAAAATTATTTTTTTTGAACTACAGTAATCCGACAAAATTGCTACAGTACTATTACGGGACAGCCACATAACAAACTTTTGAAAAATGCGTATTGCGCAACATATATGACGCGCAGGCGCAAATATCATGTGTAACGAAAACTACAGTAATAATGTATGACTACTGTAGCGTTTCTGTCGATTTACGGGCTCAATTCTAATCGTAATGTTACACGACACATTTTCGCCAAATGCAAAAAGGTGTGCGCCTTCAGATTAAAAAAAAGTTGATTTTTGTGCCGGCTTTTAACACATCGAGAAAATAAAAGAAACGAAAGTTTGTAATTACAGTACTCTTCTTAAACGCGAACACCTTTTCGCTTTTCAGAAAAACTTGCGCCGTTTCGAAACCTGGTACTATACTTTTATAATTAAATCGATTAAAAATAAATTTTGCGGTGGAGCATAAGTCATCAACTCGAAAAGAAAAAATCTTGCATGCGGTAAAAAAAAAGCAGCAGTACTCCAAATCACCCATTGGAGAATGGCTGGAAATTGAAATCAAGTCTGCACTTTGAAAAAATGCAGCGTTGAATGAGAGAGGGACAAATCGAACAGCATTTTATAAGGAGTCCAAAAAAAATGTTTGTGGTAGGTCTTGAATCGTGCAACTCATCGTTTTAAAATCAATTTTTAACACTTTTATATCATAAAAGAATAGTCTTTCATCATCAATCGATTAAAATACCAACTCTCGAAAATTAACAGCTTTGTTAACAGCGCCGTCTACCTGATTTGAAATTGCTCGCAATCGGTGCCGCTCAACTAAATGTTTTGCGCGTCACTTAAAATGCGCCCTTGTACGTTTCAGAAGCGCGTCTCCTAAAAAATAAAAAGGCTAGTCCAATTTTATTAAACGGGTATTTAATTCATGTAAATATATGAGCTGCAAATTTAGGAAATCTAGGTTTAACCTATCAAAAACTATAAAGTGGCAAAAATGGGCAATTTATGGCAACAATTCACGATCTTGAATCTAAAGGGTTCATTATTATTGGTAAAAGAGGACTAAGAAATTGATATCCGAACCCTAAAAAAATTGTTTTTCAATATTCAGAAGATATTATGAAGTTAGTGTACTTCCATTTTTTCGATTGTACGGTAAATCAAAACTAAAGGTGGGCACGGGCGTATGATAAAGTTACGATCGTTCCAATCACCAAAGTCGCATAATCACAGCCAGAGCCTCACATGAAAACCCAGTGTGTGGGAAATTTAAAAATCAGTACAAGAAAGCCTCAAAAAAAAAACAAAATTACAGGAAAAAACGGAAATTTTCAGTAAAAAATTATAGGGTATGTACAATCGATAAAAAATTTATTGAAATTCAATCGAATTCTCCGTTTGCGGCGTTCGGATCGTTCACTGAGGAAGAGTAGTACGGGATGTCGAAGTTTGAAATTGAAGAATTCGCACCAACCGGACCCCTGGAAGTAGATCGTAGGAGCTGCAAAAAATGTTCGTGGCCGCGAAAAAAATCGGTGGCCGATTTTTGTTTTTTCGGGGCCACGATGTGACTAGTCGGCGAAATTAAAATTTGTTTTTTGGTAGTGTTCAAAACTGTTGTTCTGGTTGAAATTTTATCGAATTTTTTTTTGTGGTTTTTTCAACTAATTTTTTTTTCTGAAAATACTTTTAGAACAGTTCATTTTTTTTTCAATTTTGTTCAGACCCTTACTCCCTATCATAAAGCCTCGGAAAATCGGAATCCCATCCCTGAAACTCGTGAGAACCGTTCTAGCGTGTACTTCGACGGAGGCCGGTGAATATCCAGTAGGTCTCGTTTTGGACGACGGCTTCAAGGACACGACCGAACAGTGAAAAAGTTTTATTTATCAAAACCATTTTTTTGAGGAAAAAATTTATTGAAATGTTTTTTTTTTAATTTTAAAATTCCAAAAAAACGCAAAAGGGCAAAAAAACTTGAAAAAAATGTTCATTATTCCGACTCACAATCAAAGATAATGTGTATCAAAAAAAATTAATTGTTTTCTTTTAAAAATTAAGGAACTTATTTTTCTAATGGTTATTTCAAAAAAAGTTAAAAATAAATTTTTCAAGTGTTTTTCAAGAAAAAATTAAAAAATTTCGAAATTTCCGGCAAATTTTAATATACTTTTTATTTTGCCAGGGAAAATTTGTATAAAGCTCCGCATTATATGGATTTTTTGTATTGAATAATAAAAAATTTTTTTATTGGAAAAAATGATTTTTATAGTTTTTTTTTGTTAATTTGAAAAAATTTTATCACGGCAACTCAAAATTCTGAGAATGCGTACTGCCCAATATATTTGACGCGCAAAATATCTCGTAGCGAGACGACAGTAATTCAGAATGACTACTGTAGCGCTTGTGTCGATTTACGGGTTCATTATTTAAATGACTTTTTCGTATTATTTCTAATTCTTCATTTAAATTAATTTTAAAAATTGAGCCCATAAATCGACGGTACCGTAGTCATGTTCAGGAATTACTGTAGTTTTCGCTACGAGATACTTTGCGCGTCAAATATGTTGTGTAGAACGCATTTACAGAATTTTGAGCTGCCGTGATAGAATTCGCATTTTTCAAATTAAAAAAAAATTTAGTCAAAAAAATCACGATTTATTTTTGCAAAAAAATTTGTCTAATTTATAAAAAAAAATAAAAATAAAAATTGAGCAACGCTGAGAAATCGGGCCAGATTTTTTTTTGTTATTCTTTGAAAAAAAAAACTTTTGTTGGAATTTTAAATTACATAATTTATTTGGTTCAATCAATTTTTTGGTTAAAAAGCGTTTTTTTTTCATTCAAAAAAGCCCCTCAAACATGTGCCTTCTCTCCTTGTTCGGCTACGGCCTAACTAGCATCTCATCAGGAATTTTTTTCCGCCTGGCTTCTCCATCAAATACCACACACTTCCCACTTGAATTTCCCGGGCTCAGTGCCATGCAAGCCGATCCAGCTTGATTCCGAACTTCTCAGCATAGCCGGTCACAGGATGCATAAAATGTTTAGCAATATGAATTCGGAAGGATTCATCGTCCGATTCCGTCTCATCAGGCGAAATAATTAAAAAAGTCCAGGCGTTTTGCATATGTTTCGAATTGTTGAGACGCAAAATGACTGGCGTAGGTCAGAATGCTGAGTGGATCCAAAAGTTCAAATTTGTGGCCGACTTTTAATTTAAATTTGCAACAATTTTTCAGCTGAAATGTGGTTTCCCAGCAAAAAGTTGCTCGAAAGTGACGTCATCTTAATGATAACTTCCAGAACCTTCTGCGATCCGTCTGGAGATGTTCGAAATAACCTTCCGTAGCCTTAGTCCGCACCATAATCAATTAAGCATCATTGCAAGAATCCGACTGGAAAGAGGAAGAAGCTCGACTCATTCTACCCATCAAAACTCGACTTTTTCAGGCTGAACCTGCCGATCTTTGGCCTCTACGGAGATCTTCGGGATAATCGAGCGGTGACCATGACCTTCAGACGGCGGCCAAGGATAGGATCCATGCGACACGGATTTCTGGCTCCGAGTACTTGAGTCGCTCGCTTGATTCAGCCGGAAAAGGGCAGTGGGCAGTCAGGAGGCGGAGTTGGTCGAAGATTTTTGGATCATCATCAGAGATTCGATTTTCGTGCAGCCCGGCCTTGCCTGCCGGAAAATTTTTTTAGGTAATAGGAAAATCAGAAGGGTTTTTTGGAGTTTTTATTCAGTACACCTTATTTTTTTTGTTGTTTTTTTGAGGGTTATAAGTTTTTAGGTAAATTTTTTTTGTTGATATTCTTGGTTTGTTTAAGAATAAATCATTTAAGTTAGACAAAAATTCGTTTTTAAATATATTTTCGGTTTTTTGCTGGTTTAGTTAAAAGTTTTGTTTTCGGATTTTCATTTTGATAAAAATTGAAGCCTTTTTTTTTTGGTGTCTTTCTTAGGTTTACGAGTTTTTTTTTTGGTTTTTGACGAAAAATTTCTTTTAAAAAAAACGGACTTTTTAAAAATATGGGTTTTCTTAAAAAAATAAATTTCAATTTTTTTTGTTGGATAAAAAACTGTTAAAGTTTCTTTTATGGCTGAATTTTCGCCTTTTTTCACATTCTCCACCAGAAAGAACATGAAAAAAAACATAAATGAGTAAATGTTTTGAGTATTCAGGCAGTTTTTCCGCTCAGAAAATAATTTTGGCCGGATTTTCATGGTTTCTTACATTCAGAATCTCCTCTCTGCTGTTGGCCGTGGTACGGGCGGTGCAGGCGTAGATCCGCGTCGACAAAATTTCGGGCATGGTCGGTGTCAGCAAGCTCAGTGGCCTGTATTGAAGCTCAGCCATTTCATGGATCCTTGAGACCGCTGAAATTTCGCGTTTTTTTTTGGAGATTTTGTTGAAATAACCTTCCAATATGAATCGAAAATATTTCCCTCTGAAAGCATATGAAACCAGCAGGGTCTTCTAGTTCCCCCACAGGCGAATTTAATTGCCACGTAGAAGCCGCAGACAGCAGTCGCTTCGCCGAAACAGCCAGGATTCAGTTCTGGAGATTTAGTGGTTATAGTCCAGAGACGGTCGGACGACTACTTCTAGCTGAAAACATTAATCCAGATTATGGCTTTAAAGTTTTTTAACAGAAAAACCAACTCGAAATCTAGGTTTTAGGTGCTGATTTAGCTTTTCCAGCTAGGCAAACAACCCTCCAGCGCCTCGACAGGTAAAAATTGACTATTTCCATCATAATTACAACGGAGTTCATCTGTCCATGTGAAAGTTCCTTCAATTTGTGGCTTTGGAATCCGCTATCTCAGATTTCATCTGTTCGACGATACTGGAATAGCCGTTCTGATGTGAAATATCGGTAGTCTGCTTCATCAAGTTTGTAATTATATTGACGCTGAAAGTACTAAATTATGTTTTTTCGATAAAAATGCTTTGAAAAAATACGGAAGCTTTTTATTCGAATAATTCAATTGATTTAAATTAAACATCTATTTAAATTGTTTAAATTAAAAAGTTCCACTTCTGTACTTATCACGTCGAGACCCAACACATACCAAATGGGCCTTTATATAAATTTTAAGAAACTCAACATTTTACAAGAGTTTTACAGTTTTTTTGTCGTTAAATCGTTTTTCGAAAATAAATGATTTATACTCACAGTTAACTTGCTTCGTGCGCAACTTGAATATTAGCTTAAATTTCACAGTCTATGGGTTAAATTTCAAGTCCGACTGATGATACGGGAGGTGCGTGGAAGTACGGTAGTTTGTTTTGTTTTTTTTTATTTTGCCGCCGAGTGATTCAAAATTGAATTTATATCATCCGATTTTTTGATTTTTTCTCAATACTTCTCGATTTTTCAGGAATCTTTCAGTGTGATTTTCCAACCGTAGCTCGACCCCAGACGAAGAAAGCCTGAGGCTGGTCGCCAGAAGCACTATGAATTGCGGTTTTTGATTTAAAGCATAATTTGCATTAATCTTCTAATATTTTAGCCACCCCACACCGTCCACGAACAAACTCCGAAACGAAGCTCGGGGCTCGCGAGCAGCTTCTCCGGGACTCTATACGAGTGGGTTTAAGTTCTTAATTTCATAGAATATCACTTATTCAAAAATTTTATTTTTTCGCTTCAAGCAGCTTCGGAGCCGTACGTCCACATGACAAAGGAATCCACGTGGGACGAGGCGAAAAAACTGGCTCTACGATCAGTCTAAAAGAAGCCGGACATTGTCCGTAAAGCGATATACAATCGTCGTCGCTTCAGGGAGTCAATGAAAGGATAAAAAGTTCGCTGGTCAATAGCGCGAAATCATCGACCCAAGAAGCCCGGCAATCAAATGCAGTGCGGCGGAGGTATTTTAAAAGAAGACAAATTAATATCTAATTATTCCCTTTAATCTTTCAGACAATTGCCATAAACGTTGTGCACTGCTTGGAGACTCATCACACAAAAATACTCGCTCAGAAATCAAAGCGGCCCCGCTGCTCGGGAGCCAGCGCCCAGCACTGCATGGAGCGAATTAATTCAAATTAATATTTTACAATAAACTCATTGCTCGTTTCACACATAATCATTCATGTGTTTTTCACTCTCGAAACCCATATACCCCACTCTAAATATCTATATAATGCCACATTTCTCATAGTTTTAATCTGCCCTTACCAATTAAATCTTGTCCCACCTATTTTCCGCCATGATCCCTTTTTCCATTTTGAATAAAATACGACGACGATTTTTCCTCCATTAAACCAAGGAGAATTATATAAATAGAGTCAAAAGTGGCGCTTGTGTCGCTCAGCGGTCTCCTCCACTTGCAAGCACTATCTCACCGCGGCCTTCCAATTTCTCGTCCATTTCAGCTGTAACAAGTAGTTTATAAAAACTGAAAAAAATGCAAGTTTTAGCAGAAAATCGCTGAAAATGGCAAATCGTCGAGCTAAAGTCGCTTTTGACTTCGGAGCCAATTAAAGCCATCGAGTTCTTCGATAGGCTCGTTGGACAAGGTTTGAGCCGAAAATCAAAACATTTAAGCTGAGATTTCTTTTAAAAATATCCCTTGCAGATGCCGACACAATCATCCAAGAAGCCTGTGGTGACAACCCTCGCCACCTATATCCGGCATCCCTATAAGTGTTTTTAAGCGACGGCTTCTGTGAGCTCCTAATCGTTTTTTGCGAAATTGTGCATTTCGTTTCAATTTCACAGCTTTGAAGACAAAGTTTTGCGGCGAAAATTGATTGAGCATTCGAACGATTCAGCGTGTTTTGCGGTTAACTGGAAAAGGACAAGCCACATGGGGTTTCGTTTATTGAAAATTGAAAAGATTTTTGCAAAAAATTAGATTTCATGTAGTTCAAACTAAACGCTGCTCGATTTTTAACCGAACCTTTTTCTTTTTTCCGTGAAAATATCGGTTTTCCAAGTTTTTCGAACATTTTCCAAAAAAAAATTACGTAAAATGTGAAAACGATTTTCAAGTAGCCTACAAATCCGGAAAAATCAAACTTAAATGTTTTCGAAAAATTTCATAATTTTCTTCAAATCTCTTTGAAAAGTAGATTCCACTTCTGGGAAATTTGAATTTATGTCATTTCTTTAAAAGCGCATGCTCTTTTGTAGGGTCTCGCAACGAATTATTCAATTTAAACTTTTCGATATTCGCGCCGAAATTTGGGTCTCGGCGCGATTTAAAATAAATGAAGAATATGGACTATTAATTTTTCCTTGAAAATTATTGATTTTTCGGAACACCGGCACCACGTCACCGCTGTCGGATCGAATCGTTTCTTCATTTTGACTACTTTCCGATGGCAGCCCCGTCTAAGAACCCCGACTGGTCCCCGTGCCACGTGTAATGAAATCAAATCGAGATGACAAATACACACACAATATTTTTGACTGCTGAAAATCAGATTTAAGGCTGCGGAACAGCTTCATCTTTTTTGCCGGCTAAAACGGAGAGCTGAGACGGACGGTGGTTATGTGGCACTGCCCACTTTGGTAGAATTCCAAAAGTTACTGGATACGTGGCAGATGTGAAGGTGTTCGAGGAACAGTTTTTGATTGGCGACAAAGCCCTCTACGGTTCTAGAAAATTGGTGGCGGAGTATTTTCTCGCGGCCACATGACTATTTTCTAAACGAAAAGTTGTGTAAAAGACAAGTCGGAAAGGGCGCCCTCATGGCTGTAGCTGAAACGTTTTTCATAGATTTTTTGGCTTTAAAAAAATCCTTAAAGGTGCATTTTCGTGTCGAGAATCCTAGTTGTATAATTTTGCTAATTTTGCTTAAAAATCTTGTACAGTACCAGGTCTCGACGCACACGAATAGTTTTGATAAATGCAAAAATGTATGCGCCTTTAAGGATGTAGTAAAAAATAAGAATTCCTTAAATTTGATAATTTTGTGAAGAAAAATAGAAGAATAATTCTTTGAAAATGGATAATTTTTTGGAAAAATTAGCTTTGTTTTTTATTTTTTCTAGACGTACACCTTTGTTAAAAGATTGTCGCGCCGAGACCTGATACCGTATTTCTTGAGCGCAAGATCGTGCCGAGACCCAAATTCGTGAAATCTGTCAGTTGGTAGGTGTGGAAAATTTCGATTTCCGGGGAAACGCGACGAATCTCGTCGAATTCTAGCTTTTTGTTCTGGTAGAGGAGGAAAACGAGGAGAAATTGGAGAAAATGACGACAAAATATCGATTTTTACGTGGCAAATGTGCCGATTGAGGAAAGGATTGTGAAGGCGGTTTTTTTTCTAAATTGAAAACAAAAAAACTAAAAAAATAAAATTTTAATCGTAGTTTCTAGAATTCAAGCCAGTTATAATAATTTTTAAACTAAAAATTGCATCGGTTCCGAACTTTCAAGGTTTTTTTTTCTGAAAATCGTTTAAAAAAATATCTGCTTGAAAAATCAAAATTTCAAAAAAACAAACAAAACTTGAAAAAAAAAAACGTCTTTAGCGGTATTTTTTCTATAATTTTTCAATTTTTTCAGCGATCCTTAAGAATCGAAAATCGTAATTTGACTTCTTCCTGGTATATCCAAAAATGGACCAAGATTCTGTGGGATAAAACGAGCGATTTCTCAGCGGAAAAGCCGTTTCCTTCATAACCAGTGGATTTCCAAAAATGGCAATTTTCGAATCATTTCAACTTTTAAAGGAACTATTTATGGCTGATCGAGAAATTGACTTTGCACAGGAAAATTGGAGCTATGCGGAAGAACAAAGATGACGGGGTGTTTGTGAAAAGCGGAACTGTTTTGGAGCATTTTGACACAAAATATACACTTAGTGCACTGATGGAAGTGGTCCCCGGTACTATTGGAACAACACAGAGTGTTTTTCAAAGTTTCACCAGATGGGCAGATTGATTATGAAGTTTCGTTTTGTTTGGAATTTGAAGGAATTCGACCTTAAAAATATAAAAAATTGCACTGATGATGATTATGGATTTTTTTTTCAGAAAAAACGAAAAACGAAAAAATTGAATGCTAAATGACAGAGTCAAATATGCCCCTGTAACTTTTTTTTTTTGAACTAAATTTTATATTATTTTTTTCAGTTTTACGCAAATCAAAGAAACGGGTCCACCGAATTAAATTTGAATTCCCGCGCACCAAAGAGTGACGTCATTTTTTTTTTCCCGATTTCCTGATGTGTTATTAGGTTTTTATAACGGTTTGTCAATTTTTGCAGACATTTTTTTTTAAGCTTGGTAACCCGAAAAAAGTGGCCTAGAAATCGGCTTTAATTTTTTTTTTAAATCGACAAACTGTGTTTCAAATTACGAAACAAGGAAAAAACGAAGAAGAAAACAGCCGGAAAACGCGAAAATCTCGAATGACGTAAATTGCGCGGGAAAAACTTTAGAATTTTTTTTTAATTAACAGCTCTAACATAGGGTCGAATCATCCTAGGGCTTTTGTCAAAAACCTTATTCCTCGCACAAATTGATTTTTCGTTTTCGTAGTTTTCACATGGAACAATCGAAAAATTTTGTTTCTCAAAAAAAACAAAAAATTTTTATTAAAAAATTATTTTAATCCCAAAAAAAAATATTTAGCAAACTTTAAAAATTCATAAAACATTTAAAAAAATTTTTTAAAAATTGTATTGGGACTTTATTCTAATACTTGGACTAAAAAAAACCCACATTTGACAAAAAATTCAATTTAAAATGAATATATCGTTTTGGGATACCAAAACGAACAGAAAACCGAGAGATTCGAATTCGAGTCTCCCAAAATTCACAAAATCATCAAAAATGGTGACAATGTGATCCAGTTGATATGTTAGACGCGACTATTCATATTCATCAAAATTATAGACTAATCAAGACGTATTGAAATTTCAATCGAATCGATTATTATTTGGATCTAGCCGAGTTATTTGTTTCAAACCGATGAGATGTTTTTCAACTGAACAAGAGACTGTATTTGCTGTGGATTTGGAGAATTTGGAATTGTGGAGGGTTTCTTTTATTAATTAAAATTTTTTTAAGTGGAAAAATTTTGGTTTCTCTTTTCAGAAATTATTATAATGTTGTAACTAAATATTACGGGAACACGAAATTCTAAGAATGCGTATTGCACATACACAATCGATTTGACACGCAAAATAGTAGCGAAAACTACAGTACTTCCTTTAATTACTGTAGCGATCGTGTCGCTTTACAAGCTCAATTCTTTTTAATACTTTAAATTAAAACTTTTTCTTTAAATTTTAAAAAAATTCGACTTATTTTTTAATTTTTACTTTATGCCAATATTCTGTCGATAAATAAATCATTTTAATAATTAGAAAATTGAGCCCGTAAATCGACATGCGTGAATCCATTTAAAGAATGTAGTTTTCGCTACGAGATTTGTACTCCTAATTGCGCGTCATATATGTTGCGCCGTACGCACCGTTCTCAGAGATTTGTGTTCATATAGAATATTAGGACTAGTATGTTAAAATTTTTAAAAAGTTTGTTTCGACTTTTACCCAAAGATCTTTTTTTGCAAATTTTTAGTGAAAATTATTATTTTTTACAATTCCGCACGCTAAAATTTATTAAAATTATATTTAATTTAGACTGTATTCTATACAATCAAAAAACAACAAACATCAATAATGAATGTTCAATGAGTTTAAAGAAAAATTTTTTTGTGTAGACTTTTTTAAAACTCTTCTTCGTTGACAAAACGTTCACAAAACTTAAAATATCTTTCAATTTGCTTAAATATTAACAAAGAATTTTTAAAATTTTTCAGCCCGAAATACCAACCTATATCACCAGAGGAATTCGTTCCCACCGACACTTCTCCCTCCGATATCTGGTATTTCAAATCCCGAAATTGAAATTCCCTTCTCACAAGTACCCTCTCCTACTACATTCACGTCAAATTGGAGCTCCAGAGATTTCATTCAAATAATGGGAATTTCGATATGTAAGGATGGTAAATCAGAAAATGAAGTGGAAATTGAAGCGAATGCAGTGTTGAAACTGTGAAAAATGCGCTGAGAGTGATGCTCAATATTCGACCTCTTCTCAAAATTAAGACTATTGAGGTAATTGGATATTTGGTGAAATTTGAAATGAAAAAATATTTATAAAAATTGAATTTTTTTTCATTATTTCAGTCACCATAAGTCAATAGCCGTTTCCATTAACTTAGATAAAAATTGATATTTTCTTTTTCCAAATGCGATAAAAATTGGAAATTCTATAAATTCCGGAAAAATCGATTGATTACAACAAAATCGATAATTTCCGGAAAATTGATAAATTCCAGAAAATCGGTAATTTCCGGTGTAAAAGTCGATAATTACCGGCAAAACCAATTAATTTCCAGAAAAATCGGTAACCCTTACCGGAAAAATCGATTGATTATCTACAAAAGTCAATAATTTCCGGAAAATTATGATAATATCAGAAAAATCATTAAATGATCGATAAATTCCAAGCAAAACAAAATCGATAATATCCTGACAAGTGAATAAATTCCTAAAAATTGAGGAATTTCATAAATTCCCGGCCTTGAATATTTTTTAAATTTAATCTTTAAAAGAATAATTCTTTAAATCTTTAATCCTTATCTAATTTATTCAAAAAAAAACTGATCCACAAAATTTTTTTTTTTCAAAAATTAAATATTTTTGCCTAGTTAATGTTTCATCAACTTGATTATCATTTACTCGAGAAATGTTCAATGATTCAATGCATTCTAATGGAAACAGCCATCACTGAATTCACACTTCCATTTCTCTACGAATTATTCTGTCGTATTCGGGTTATGAGGACAAAGTGTTGGATGGACTTTTGCCGAGGAAATCTTTGATCATTTATAACAACTCGATTTCCAGTGTTTTACCGCCAAATTCTTTGTACGGTAAGTGAGTTAAGAAATGGAAAAAAACACATTTTTGCTACTGTTGGAATTTTTTTTCTAAATTTCACAAATATCTTATTTTCCATTTTAAAAGTAGAAGTTTATTTGCTGGATTTCATATCAATTTTTAAATATTTTGATTTTCCAGTGCGGAATTTCTGTGTTTTTTGAAGCAGGAAAAAAACCACAGAAAACTAACTAAAAGAATTAGCAAAAATGAAAAACATACGTAAAACGATGTAACTTGTCCACGCCACGTGTAGTACAAAAAACCGATGTGCACCAACAAATTTTTGCAAAAGCTATTTTTCCATTCAAAACGGCGCCCCAACAGTTGAAATTTTATAGACGAAAATTTGCGAAACTGTTCGCTTCTCCGAAAATAAAAGTCTCAGATCCCATTCTTGGGTCTTCCAGATAATCGTTGAACTCCAAACTGGAGACCGGTTGCCGCCGACACCAGGAGCACATTAACAGTTCCGTCGAAATTCAAAAATCTAGAAAATCTGAGCACCTATGAGCCCCAGGACATTGTCAAATATTTTCTGAATCTCGACCAAGAGTCGGAGGATGTGACATGGCGATCGATACGTCACGAATTCCACGACACACTTGACACGTGGCACGCGGAAGCTGTGAAGAAGAGAGACGAGAGACGTAGGAGCAACACGGAGCAGAAAGAGTAGTATTCGTAAGGAGAGCTTTACGAAAATTCAAAAGGCTTCGATGACGGCATCGCCGGTAGGAATATCGATTTTTATGTATCGAGGAATTTACTGGAAAACAAAGTTTAGGAAAAATGTCGATTTTCCAGAAATTTATCGATTTTCCTGAAATTCGATTTACCTGAAATTTATCGATTTCCACCCTGAAATTTATCGATTCTGGAAATTATCGAGTTTTCTGGAATTTATCGATTTTCCTGTTTTTTCTGGAATTCGATTCTTCTGGAATTTTTCGATTTTTCTAGAATTTCCACAATCGATTTTTCTGGATTTTATCGATTTTACTGAAATTTATCGATTTTTCTGGTATTTTTCTGGAATGTATCGATTTTTCTGGAATTTATCGATTTTTCTGGAAATTCGATTTTTCATATATCGATTTTCCTGAAATTTATCGATTATTCTGGAATTCATCGATTTTCCTGACATAACAGATTTATCAATTTCTGGAATTTATCGATTTTTCGAATTTATCGATTATTCTGGAATTTATCGATATTTCTGGAATTTATCGATTCTTCTGGAATCGATTTGTCTGGAATTCATCGATTCTTCTGGAATTCAGTTTTTCGAGATTAATCGATATAATTGTCTGTAAATTTTACTCCCCAAAAAACAATATATCGTGCCGAGACACGAAAAACTCTAAAGAATTACAGATTCCAATCGGGGCGGCCGCTCGAGTAGAACCCGAAAGTTTCTAAAAATCAATCAATAGTCCTGTCATTCGCCACTCAAGCTCTCCCTCACCAATCAAAGGAATGCCAGAGGTAATCGTCGAGAACCAGCACGCCCCCTGAGCATTTAAATTCCACGTTGTAGTCCCTGAGCCACGATAGTATTTCCAATTCACTGGACGCCGAAATGAACATTTCACCGTCACCCTCGACACCGAAATCCTCTTCCTGTGGCGGAAGGTCGCATCGCACACCAAAAGCGATTTAAAAAGTGATTTCGAAATTCCGAGGTCGTGAAACCTTCCCAGTCACCACAGAATCCTGGGTGGAAAATGGGCGGAGCTTCCGCGTCGATTCGCGAAGAAATTGATCCGCAGGAGATACGCGACGAAGTTGTGAAGAAGGAACAGAAATTGCAGACTAACGTGCGTCATTTGAAATTTTTGAAAAATCGATAATTTTCAAAAAAATCGACTTTTTTTGGAAATTATCGCTTATTCTTGAAAATTATCGATTATTTTAAAAAATTATCCTCGAATTTTCTGAAAAGGATCTGTTTTCGGGCAAAAAGTTCCGAAAGTGTTTTCTCGAAAAACAACGACTTTTTTTTTGAAAGTTATCGATTAAAGAAATGTCATCTATTTCTTTGGTATTTATCGATTTATCTTAAGAAATTATCGATTTAAATATTTTAAGGAAATTATCGATTTTTTTAAGGAAATTTTCGATTTTTATTTATCGACGTTTTTTTTAGGAAAAAGTTTCGAATTTTCTCGAAAAATAACGACTTTTTAATAAAATTTATCGATAAGAATCTATGTTTTTTGAAATTATCGATTTTTTTTGAAAATCATCGAAAATATTTTAAGGAAATTATCGATTTTTTTGGAATTAATCGATTTTTTAGGTAATTATAGGCCGTTTTTTTTCAAATTTATCGAGTTTTTTAGGAAATTATCGATGTTTTCTGAAAATTATCCCTCGATTTCTTACAAAGGAAAAGTATCGATTCTTGGAAATTATCGATTTTTAAGCAAGTCTCTTATCGATTTTTCAAACGAAGAGTAAGGAAAATTTTTTGAAACTATCCATTTTTCTTTATTGATTTTTTTCCTAAGAAAATATCCATTTGTCGATGGCTAAAAATGTGGATTTTTCTGAAAATAATCGATATTCTGTTTGGAAATAAAATATCGATTATTTCTAAAAAAAATTATCGATTTGTGCAGGAAATTCTCGATTTTTAAAATAAAAACAGCGATTTCTTTTTTGAAAATCGATTTTTAGGGAGATTATCGCATTTTTCTGATTATCGATTATTTCTTCAAAATTATCGATTTTTAGAAGAAAAGTATGGATTTTTAGATATAATCTATTTTTAATTATTGATTTTTTCACCTGAAAAAATATCGATTTTCTGAAACAACATATAATACCACACATTAATTTCAGGAACCGGAGTTCAAAAAAGTGCAGCTTCTACCACACGTGGAGACGGAAGAGCTCGACGGAGCTCAAACTTTGGAGGTTTTTCGACGAGAAAGGAATTCACGATGAGGCGTTCATACGCTTGTGTAGGAACTTGTGATGGTTTTTCTCTCAAAAATTTGAAATTCTTCAGTTGGAACTGGTGTTTGATGCGACGATTTGGAGGGGAGTTGGAAAACGAGCAGATCATCTGGGGAAACATGCCGGGACTTGTTCGACGTTAAATTTTCAATTTTTGAATTTTTTTTCTCTTGTAACTTGCATTTTTCGTTTAACTTAGTGTTTTCGGTGTTTTTTGGACTATTGAAATATTCGGGTTGTTAATATTCAAAAATTAATTACATTATTAATAATAAATGCATTTTGAAATGGTATAAATTGAAAATTTTCAAAAAACCCCCAACCCAGTGGTTTAGGATGAAAATCGTGGAAAAGCCGAACGAGAGAGTTCCGAGTTGGCCACGTGGGACTGAAGCCTAATTGAGTGAATTTAATTTTGGATAAAAAAATTTTGGAGATCTCTTCGACATTTTCTCAAAAAATGATCCATAGCTTTTTCCCATTTTTTTGTTGCTTCATTTTCAAGCTCTTCGGTTATATCGCAGACGTTGAAGCAAGGGCCTTCCGGGAGAATTTCCTGAACATTTGAAGCGCCTTTTTGGGTGAACAAAAGCAGCTTAAAGGCATTTTTTGGTATTTTCAAATAATATCGGAAATCTGCGTTTAAATTTTTTTTTTAAAATGAATTTTTTCAAATAGGTTTTCGAAAAATCGAAAAAAAAATTTTCGGGTTTCCGGTGGAAATTTTAATTAAATTATGTGTTTATGATGATGAGAATAGTTGACAATAATTTTTTCCGATTTGTCAACACGTTTTTCAAAAAATTTGTCAATATAATTTTTTCCATTTTTATTCCTGAACAGAAAAAAATCGAAAAATTTTCGGTTTTAATAATATTTCGGAAAAATTTTGAATTTACCGTAGTTGTGTGATCGTTAAAGAAACTCACAATATTTCTAATCGAAGTATGCATATTTTTTAAATGAATTTTTGGAAAAATTTCAAACTTATTTTTTGTTGAATTTTTCGTTTTCTTTCGTTTTTTTAAACAGAACCAAATTTTTCACCATCTTTTCTTCAAAACAAAACAAAAAAAACCAATTTTTGTTTTTTGAAAAGCGAGAAAAATTTCGAAAAATTATTTTAAAAGTTAGAAAAATATCAATTTTGAACGGAATTTTTTCAAAATTCGATTTTTTTTTTTTCTAATATGTTCGAGAGTTTGTCGCCATTTTTATTTTTAAAAAAGGCTTTCAAACTACAAATTTTAAATGAGAATTTAGATTTTTTTAACGAGTAATGTTGAATATTGGAGAAAAAATAAATCAATTTTAAATAGAAAAGTTTTCTTATTCGTAACATTTTCAGTGTTCTCAAAATACAAAAAACTCGTACATCCTCCTGACAAGTACAGTAATCCATTGGATCCCTCCTGTCCAACACCGTCGCTTCCCGAATGTGAACCAATTGTTCATTTTCATAAGAACCGAGCTCACAGTCAATTTCCCGACCATATTTCCCTCGTATTCCTTCGAAAATGGCTGAAGCCCGATTCAAATTTCAAATATCACGGTGGTGGAGAGAATACGGACAATAGATCCGTAATTGATTTAACTTTAAAATTTTTTTCATTGTCATAATCATGCTACGTGGTCTGGACATGATCTGTTAAATTCTCTCGTTTCGGCGGAGAATATAATCGATATTCCAGTGGCACGAGGTTGTCGAGAAATCTATTAAAATTCTGATAATATCGTTCCAATCTCATTTCGAAGCTCGTCAGTTTCGGCTTCAGCTTTTGAAGCCAGTCGTTTTCAGATTGTGCTCCAGCGCGTCTGAGCTCTGAAAGTTTGATTTCAAGCAAAATTTTGTGTAAATGATTCAGACAACCCCATTTTTCATCTAATTCGAAATTAGCCACATCTAGAAATTAACCACATTGACTAATTAGAAAATTTTCTAATTAGAAAGGATGAATATCTAATTAGAAACGCTGCACAACACATCTAATTCGAAGGGATGCCTCGTCGAATTAGAAATGACATCGAATTAGAAAGGTGGCGCGTTGAATTAGAAGTTACGCGTCTAATTAGAAAGGAGGCACATATAATTAGAAACATATTGCGCACGTCCACATCTAACTAGAAGGGATGCTCGTCGCATAGTACTACCTTTTAATGTATGTACTACCTTTTAATGTATGTACTACCTTTTAATGTATGTACTACCTTTTAATGTAAGTACTACCGTTTAATGTATGTAGTACCTTTTAATGTCTGTACTATTCTAATGTATGTACTACCTTTTAATGTAAGTACTACCTTTTAATGTATTACCTTTTGGCTCTTTGGAAATATATCGATCAAGAAACAATGCCGAATTAGAAAAAAGGCATGAACTGGTGCGCGTTAGTTGACCTTTTTTTCTAATTAGATGAGAGGAATATGGTAGTCAAGACTGCAAATTATCAAAATTTTTTGGTTCAATTTGTTTTTGAAAAAAGTGAAAATTCCTGGGTTGCAATTTGTCGATCAGTATTACGTAGACGTCGAAATATGCGATTCGCCATTGCGGTCTTAGGGGTCTCGCCACGCCGACAATCAATGTAGTTCATGTCGATTTACCACTGTTGCATCGTAATATTCCAACAAATTTGCCGCCGAGGTGAAAAAATTCAATAAAAGCCCGTAAATCGACATGAACTGCAATAGGGTTGTCGGCGTGACGAGACCCAATTCTCATCTTTCGTACCGACGTCCACGTGATATAGAACTTTTTTTTTTGAAAAAATACGATTTTGCCTAAAAAAAAAACTGTAAATTCAACAAATCCCACAAAAAAAAAGCGAAAAGAAAAAAGCATCGCGGAAGACAGTGGCGCCAGGCTGTCTCAATACTGTTTGATCTACAAAAAATGCGGGAATTTTTTTCACAGACAAAAATTGTGACGTCAGCACGTTCTTAATCATACCGAAAATGAGATTTCTGCCTCTGCCATCCCGCATTTTTCCAAGATCAAAGTGGAAGGACTTTCACCTGAATAGGACTTTCTGATTCCACGTGGGAAGGAAGAGAAATCCAAAATTGCGATATTTCACTAATTTCCCTGCTTGAATTTCCTTCCAATCAGCGTCTTCAAACTCCGCGGCCCACTCCATCTGTGGATGAAAAATGGGCGGCGCAAATCGCTCTGATTGGTGGCAGTTCTTATTGCCCAATCATTCAAGTTCAATATCTGGATTTTTCATTTTTGACCACCTCCAATTTCAAGCTTCTTCCTTACCTTCAAATCGTAGAATATTGCCGATTCTCTCGGATTGATTCCTTCCTTCAAAACCAGAACATCTTTCAACTCGAACCCCGAAAGCAGATATTTTTTAACCTGAATTCTCCTAGAATATCCTTCGCTCGTAGCAACTCTCCAACGATTCCTTCTGTTTGTAGAAACTCTTGTAGAGTGTACACTGCCTCGTCCAGATCTTCGCAAGATGCCCGTAATTCGATCTTCCGAGCTAGTCAAAATTGCATATGTTGGTGTTTTTCGTTTCGAGCAACACATGCCAATGAGGATATAATCCGAAGTTAGACTCGTTGTTGTTAAAACGCTTTATAATGCTGGCGAAGATTTCCTCGAATTTCGTTTTTCTTTCTTGAAATTTTATCAGTCTGTATAGTTTTGAGGGTACAATAAAATCTCGGGACAACTTTTCGATATCTATCATCATCGTCATGTTATAGAAACCTATATACTACAGTGTTTTTTGAAGAGTTTACACCACGATACGGATTTTGATCGGTTTTTGATGATCAATTTGACTAATACGCTCGTCTCCGCAACGTCTTAATCGGTCCTAATGCAAGGCTGTGCGTTGTGTACAAGTGCCTTGCTTAGCTCTTCAAAACCGGAGCGATACATAGACACGAATCGTTTCATGCGCAGCGCAGCTGCTCAGGGCTCTCGAAAGTTTTCAGACATTCCGTGAAGCTCTCAACAATGCTGTTGAGGTTATCCTTTGGCACATTTTCCCGAATTTGATTAACTTGTGATAGATATTTATCTGATATATTCGATATTTTTATGATATTTTTCCGTGTTGTTTAGGATGTTTTGCCATCGCAAATTCAAATTCCACATAGTATTCCAAAAACTTATTCAATGGATGCAGGAAGTGAATTGATCCTTTGGCAGAAACGCTTTATATCCAATAATTGCTCTGCACTTTTATCGTCGAATAATTTCTTCACGTTAGATTAGGGAGCCCTAGAGATCCACGAAGTATCAATTCGTTTTTGGGAAGGAATAATTCAAAAATACCCAAAAGAAAATAGCCTGATGGCCTGGAAGAAAGCCGTCCGAGGATTGAATACAACGAATAACGTCCCTGACCTTTCGCACCCAATTTGAAAGCCCCAGTGTCGTATTGGTGTCGCGAATAATTTCTAAATCAAACGCCCCTTCGAAATTGTGTCCCACTGACAAGAAGTCTCGAACACTTTTACTCGCTTCATTTTTCATTATAGTCGTAGCGGGTTCGAGATAAAATGGAGATCTTGAGCAATGCGAATACTTTCTTGGCTCGTTCCGGAAGCTAAGAAATTTCTGTAGTAGGCGCCAACCTCTTCGTCCGTTTCATATTTCCGATCTGTACGATCATTAAAACGGCAGAAATCTGGGGAATATTTCTAAATAACTCCAACTTTGCTCCTCAATTATCCATGTGAAAAAATTCAACCCGGATTTTGAATTTCGGCTTGAAATTGCCGAATTCCCTTGGTGCACACATGCAAATTTTTCAAACGCGCGGCCCAAAAATTATTATCCTTGGAGCGCGTTTGCCTGCTCATTTGATTCTCTCCCGGAGCACGGTAGCTCAGAAACTAGATGGATGCTGGTTCATTCTAGATACTCAGTCTGGATATATTGGCTACTATCTCGACCCGGAAACCATCCACATAAAATCGATCTTTGCGATGCAAATAAGAAATGACCGCAATGAAATTATCTATCTCCATTCGTGATGAATTTTCGATTTTGTACTTCCTGGCCAAGTTTATGCACGTTTGTTCGGAGCGCGTTTTCACCCATCTAGCAACTGACGGTTCAGTAGCCAATATAGGTTTCACTGTATCATGAACCACTCCATCTAGTTGCTGTGCTACCCTCGTGCTGAACCACCGTGCTCCATCTACCGATTTCTTCCATTACGATATGGCTGCAATACTATTTTTTGATGGTCTTCCCGCTTGGTCAATACTAATAGGGAGTGCAATACTAATTTTCAGAACATTTTTCTGCCTTTGAGACTAGTTTTTTTCTGAAAAAACTCGAATTTTATGTAAAAATTCAGTCCAAAATTTGTTTTGATTGTAACCTATTTCAAAAATTAATCTCGTAGAAATTTATTTGAAAAATTGCTGCAAAATATGCAAAAAATATTGTAGAAGTCCTAAAATTAGCGAGAGGGGATTGCAATAAAAAAAGTAAACGAAACACTATTAGGGAGTTCAAGACTAATAGGTGCCAGACTAATTTTCCGCAGGTCTCCGAGGGGCAATACTAATAGGGAGTGCAAATCTAATAGGGAGGCCATGCATACTAATAGAAGAAATACGGTATTTTTAGTTCCTTTATTTTGTCAACGAGAAGAATCAAATGAGGGCACCAAACGCGCTGCAATAATACTATAATTTATTGTGCGCGCAAAAAAACTCATTCGGCACGCAAAGAATATTCACGAATTTATGCTGAAATATAATATCAGTTTTTATGTTTTTTTTTAACATCCAGATATTCTGAAACAGAGGAATTTTTTTTAGTTATTTGACAATATTTCCTAGATTTCGGAAATCATGTAAACAGCAGCTTTTGTACAACAGCTTTTTTTTAACTGTGAAACTTGTTTAAAAAGTCAAACCACGTCCATTTTGAAAATTAATTTTTAACATATAAAATAAAAACATGTGGAAGGCTTTTGATTCATGTACATACAAGTTTTGAAAAATACGGCATTTAAATTTGAAAAATGTGTTTGCTAAAATCTGATCAATTTTTTTGTTATTATCTATTAATAGCTGGACTTTACTTTTAGACAAAAATTACTCTAATTAAAATCTACCTTCAAACCATTTTTTCAGTTTTTGCAAATTCTCCTCGGAAATCAGTAGGACTAGCGATCGAGTGGCAAGTGAAAATCACGGAAATTTTTCAGGCGATTTTTCAGGCCCCATGTTGCCACGCCAACCATATTTTGGTTTCATGAGAGATCGGAGCTCATGAAATAAATGCAAAGCAAAAATCCAGCGAGGTGGTGATCTTTTAGTCATTCTCGCTGTACTTGAAGATGTGGGAGCTTCTTTAGTAAAATTTACAGCATTCTTCTCTATCCTTATAAACATGTTAGTCATTAGTGTTCTTTTTTCCCGACAATCTCCTTTCGAAAGCTCTCTGCTCATCCCATCCCCCAATAGCTTTTTTTTTGTAGAAACTTGAAATCCTATCAAAATCTATCCCGATCAGCTGATTCGTCAGATCCGTAGAAGCGATTTCGCCTCTGAGAAGCCCAGCGACGATACGATAGCAGTAACACAGGAGCGGTGGTAGCAGGTGAGCTCATCCAGTGAATCCGTTCGACAGGTTTATAGAGTACTTTCCGTAGAATTACTGAAATTATATTTACTATTAAAGTAGAAAAAAATGATTATATAAACTAACTATACGCAGGAAGACTCGCATTATGTTCCAGATTTCGACCTAAGAATTGTGGATGGCGTCCAGCCGGAAATTTTTATTTAAATTTAGTAAATCCTTTAGTGAAGAAAGTTTTTTAATAAATACCTGTCAAGCGCTTACCCTTAATGTGCTCCAACATTTGAATACCTTGCCGCTCCCTTTCCGAAATTTCGAGATCTCCGCATCAGCGTTTACCCGGTAACAAGAAGTAAGGGAATTATCGTTATAATCATCTTTATCTGGGAAAAAATTAATTTTCATGGAATATATTTCAAATTTTCGACAACCAAAAAAATTCACATTTTTTTCAGGAAATTTCGTTGAAAAATCTGTTTTTCATAATATTTTGAGAATAAAACAAGCGTAAAGGTATTCAAGAGCGCATGCAATTCACTTAAGCCAGGGTGACCCTCTAAGCGAACATAAAACATACGGTATTTAAAAATATTCTTGTTTTCCGCGGAAAGTCGGAGAATTTAATTTGATTTTTTTTAAAAAAAAAGAAAATTAACCGTTATACGTTTTGAGCAAAAAATTCTACAATAATAATTTAAAAAAATTAATTGAATAAACATTGAAAATAAAAGTGCTTAAATTTCAAGGCGCTGCGCGTGCATCAACCGTCACTTTTGTTTGGGTATCACCCCAGCACCCCGAATGTAAAAAGTACCAGGGTAAGAGTGCGCGCTTTTTTTCATTTTTCGAATTTGTGCGACCAGTTCTCATTATTTGAACGATTTTTGCGGTAATTTTGGACAGCCATTTTTTCTAGTTCCCACCGACAAATTGCATTATATCCGTAATTTCAAGAAAATTTTGTTATAAAACCAACAAAAATCTAGAAAATTGCTGAATCATTTTGCGTATGAATGGTCAGGCGGATCTGCTCGCTGCGACCGAACCGCCTATCGGGTCTTCAGCCGACAATCTCTACGACATAGAACTGTTCGAGGTGTTCAATCGTGTCGCTAACGTCGTCACAGAAAAGGCGTTCTATGGAGCCGCCCGATCACGCTCTCGGATCATTTGTTTTCAAGTTGGCATTTTTTTTCAAATCATTTGTCCTCACCTAAATCTCTAATTTTCCTATTTTCAGAATTCAAGGCCTGTATCAAGCTCGTAAACTTTCAAGGAACAACTCTTCACGGCCGTGCTGCACATTCGTCCACTGCGAGAAAGTTCGCACGCGAACAGCGAGGCCATCTCAACGATGTTCGAGAAGGTCAAACATAAGGGAAATTCCGGGAATTCTTCGTAGCGTCCAGAGCACTCGTTCCCCGAGTACCGAAACCAGAACCCACAGGCTTCATCATACCTTCCAGTCCACGTGGTCATCGTCGACGGGCAGTCTCAATGGTGGCGGCGGGGGCTATCGACGCCGACGTTCCGCCGGTGGCAATCAGTACAATCAGAACAAGTATCCGAACGAAAGGTACCAGGGATGACTCGATAATCATCCAGTGCAGCAGTATTCGGGCTTCAATCCCAGCGATTTTTGCTGTGATGACTATGTGGAAGGAGCCGAAAAGGTGCAAAATTCGCCAAATTTCGCTAAAAGAAATTTCGCCGACTTTTCCCGTAGCGCAACAGTTTTTTCTTTTAGGCACATTTCAGGCATTTTGGGCATATCAATATTTTTCCACCAGATATGTTCTAGATTTAGATGGACTAGATTTTATTCTCAGACGAATCAAGTGATTTTCTATATTTTTACACTATTTTTTCTTGAAATATGACCATAAAATGCAACAAAGTCTTCAGCAGCTGATGGGAAAAGGAAAAATCGGCGAAATTTCGAATTTCAGTCTATTTAATATGTTTAAGCAAAAAGAAAACTAATTGTTGAATTTCAGACTCGACAACCTTGCCAACCTGATTCGCTGGAGCACCTCCACGGATCCGTTCGCAACCTAATTATCAAAAGTAATTTTGAATTATTTTGAAAATCAATAAATTGTTTGTTTTCAGACGTGAATGCACAAGCACATCTTGTTCTCGTACGAATTGAGCTAAAGATCAAAAGCATGGCCCGCCAACGTGGAAAATGGAGCTGCAGATTAAGAAAGATGACCACCACCACTAGGGCCGGCGGCGGAGCAGCAACCACAGGACAGAACAGACTGACCCCACAACAGTTTTTGGCTCAGATAGCTCAGAGACAACAATCGGAGCAAAACGCGGATGAGGTGGCCAAGAAGAAGCGTCCGAACCTTTCGGGTATCAATCCAGCGCTTTTCTACATGAGCAATACCCGAGAACATCGCCAGTTGTTTATGCTTAAAATCTATAGAGTAATATGGAGATTTTGGGAAAAAAACATATTTTCTCGAAAATACGCCCGAAATAGTGTTTGTAAATTGGCGAGACCTATTTCTTCTGAAAAATTATAATTTTTTCGATTTTCACGTGAACTTGCAGGTTTTTGGATATTTTTCTCGAAAAACGTCAATTCATCGATTTACGCTAGTATACTCAGCAATCGACCCATTTTTTCGCAGACAATTTGGTATTTTTCTTAACTTGATTTTTATTCGACTTCTCGTGTAATCACTTATTCAAATGCGCGCCCTAAGAATTTCTCATTGGAGCGTGCTTGCTTCGTGTAGATTTCCGAGAGCTTTCCATTTATTTTAACTTCTTTCGTGCTTTTTCAGTTTTCCAGCGACTTTCTGGCTCGACCCCTCGGTATATTTTGTGCAAACACCGTCACGCGCAAATGCATGCCCTTTTTCAACGCGCTGCGTGAAAATTCACGCGATTTCAAATATTTTTTCCCGTAGTTTCCAAAATTTTCGAGAGCGGGGGGGTCGAGCCAGAACACCTTGGTTTTCCAGCGAGCTTCCTTCATTTACGTCGATTTTTTTTTTAATCTTCGTTAAATCTAAAAAAAAACGACTTAAATCATTTTAAAGTTTCCAACGGTTTTCTGCATAAAAAATCAATTTCCAGAACCGTCCGGCCACTACGACGACAAACATCTCCACACGGCAGTTCTCGCTTACGGTCGCCTTCGTGTACCTCAATCGGCCTTCGAAAGTCTCTCACCAATCGACAAATTGCTCATTCATCACATAAAACACGACAAACAACCGGTGCTGAAGCGTGATTAGTGACGACCGACGAGTTGTCGGATGCGAATGATTGTAGTCTACTGGAAATCTCCGAATCAATCCAAACCACGATCATCATGACGAACCGGCACCAAGCTCTCCGCTGAAACGTCTTCGCGCCGAAAGTGGATCCCTATCAACTGCACAAGGCGCATCGCCCGAGTGTCTCACCGACAAAGCAAAGACAATAGAGTTCCACGAGACTGAGATAATGTTTTTGAAACTGGACCACCAGAAGACCAACAACTACAGCTTATCCGAAGGAAACGAAAACGCGGATAAGATATGTGTTGAGCAGCCGAAAACCAGGTAGATCAACCGAGTACGACGACATTAATAATAGACGTCTTCCGTCGAATTCTCATTCGGCAGCACCGAATTCCGAGAAGAAGCATTTCGTTTTTCCGGCACGGGGGCTTTTTTTTGATTACCTAAAAAATTCCCAACTTTTTAAAGTTCAAAAAAGTCAAAATTTTTGTCCATCTGGGCATGACTGCTTATGCCCCGCCCCCCTTTTTCGAAGTTTCTGCTTTTAGGAAAATGTATTCCCAAAGTGCCAGTTTGGATGCCCCACGAATCAAAGGGAGCAGAACGAAGGAGGCACCACGTATTCAAGATCTGGTGCGATTCCGGATCCGGCACCGTACAACTTGAAAACGTGGTGCCTTTCTGAGGGAAAATTTGCCTGCCAAGGTTGAAATATCGAATGCATTACCCGTAAATCGACACGAACTACAGTAACCTGTTATCCGCGTGGCGAGACCCATGCGCGTCATTTGTCGAATATTATACTAAAACCTTTAACTTGCAGAAAAACTTAATTTTTTTTGTTAAAAATTGAGCCAAAAGACTCAAAAATTTCATAAAGCGAAACTTTAAAAAAATATAATTTGTTAAAATTTCAAGAAATATTTATGAATTAATTAATTTTTCCAGGAATACCCCATGTGCCGTCTCTCCAGTTCCATCGGTTTCTCACTTGGTCGGTGATCTGACTTTTGCCTACACGATCCTACAGCCGACGCCATGAGAAGATGCTGCTCGACGAGGCGTCTTCAATCATCGAAAGTACAACTCTAGCAGTGTCTACTGCTCTGTTCTGCTCCAGGAGCTACAATGCTCCAAATATAGGGTCACATATACAATCATATAATCTTATTGCATTTTCGCAATTTCTCTCCACACACATACACACATCATCCCAAGTATTCGTGTGCTGAATCTCAGTTTGAATGCAATGTTTCGATACCGTTTTTATCCCACTATTGCCTTATCGTTTCCTGTTTTATTATATTTCATATATATTGCCACCACCACCACCAACACCACCCTCTCTATCTTTTTTTGTTCTTTTGCTGCAACATCATCACCTAGTTTTCTGTGAATTGAATTTTTTGTTCCCCCGAGTCCCCTCTGATAGGATACATGGTAGGAAAGACAATGAAAATACGAGTTTTTTCAAGGAAAAAAAAATACAAACTAGGAAACTATAGAAACAAAATACTGAAAAAACATTTGAGGCGCAGTAAACCTCTGCAAAGTTCGCAAATCCAAAAGAAAATATTTATTTTTCTAAATTATTTTTCCGCCACTCCAGCCTCATTCTCATTGGCGGGCGCAAAGTCATGTCGATTTACGAGATTAAGATTTTCAACGAGTTTATTGTTATCGATTTGCGTGTAAAGTTAACTAACTTTTTTGAAAATTTTCGCAAAAAATTTTATAAAATGTTCAATTGGCACGAGCAGATCTTCAGCAAAAAAACCGACAGAAATGTGTTAAACTGAATCTCGTAAATCCACATGGCATAATCCAATGAGAATGTTTTTAGCGAAGAAGTTTGAACAAAGGAATATCAAATCAGGGCCAAATTTGGAGCAATTTCTAAAATATTTTCTCAATTCTTTCGGTATTCCACATTCAAACAATTATTCGGCCGTTCCCAAGGTGATCAATCTTTCGATGGGATCCCTTGGTACTGCAGCAGTCAACAGCTCAATCCCCAGCTTCACTATTCGCCACGTCATCCTCGATACGGTATCTAATGGAAACTCTTTGACAGGCCAATCCATCCGAACCTACACTCCCGGCTCAATGGTAAATGGCACATTCGGTGGTAGAATGTCTCGTGATACTGTTGGACGATCGTGAACATCAATTCCCAGATAATGACTGACGTGGTGGGGACACAGCTTGTCCGCCTGATTTGATGAATCATCTCCTGGTGATGATCGAATCAGGTCGAGTTCGGTGAAACTTGCCGCGACAAGTTCGTTCATTCGGCGTAACAGTGCGCTTAGGCGGACTTTTTCCCTTGAGTGGACGTAGGTGAGCAGTTCTTCGTGAACGTACAGAAGCGCTTCGTAGAGGGATTGTTGGGCCTCTGACCAGCTGCAAAAACGAATTTTTTTTTGGGAAGGGTTTTTGAAACAATTTTTCAAATTTCGGTCGAAATTAAACTTTAACCGTAAAACGATTATCCACGGATTTCTGGCTTCCCTCATAAATTGGATTGGAAGAGTTTACCGAACTAGACCATTTTGGCTCGGCTATATCTGGCGCCGAGTCGCGATTTTAGTTGTAAAACTAAATGCATTTGTACATGTGGAGTACACGACTTTGCCACGCGTTGTCCGGCGGGCGATTGTCAATGGATCCTGCATGCAAAAAAAAAAGTTCACTGAGGAAGAGAACTCCGTGATTAGCACCCCCTATTTCTCTTACGAATCTATCTTCGAAATCTTCTATTTTTTAACAAGTCCTGAATTCTGAAATTCATTATAGTAATTTTTTGGGAATCCTTCCATTCCTACGGAACAACATCTCGGATTGGTGACTCAAATTATCTGAATTTTCAAAATCTCCAGAAAAAAATATCATTTTGCCTGAATTTTCTACTTTTAACGGAATAAAGTGCAAAAAAGACTCTTTTTGAGGCACCACCGAAAGGAGAAAGGAGAACACAAACCACGCCCATTTTTTCCTCGTGCCGCCATCGCGCAAGTTTTTCTGCGCGCAAATTTTTATTTTCAACCGAGACAGCAAAACTCCGAAATAACGCATATGTTCTTTATCATCAACGATACTGTTATTTCGGAGCTTCGTTGTCTCGTTTGAAAATAAAAATTAGATGCAGAAAAATTTGCGCGCGGCACGGAAAAAATGGGCGTGGTTTCTGGCGATTCTCCTTTTTCGTGTCTGTTCTCCTTTCTGGTGCCTCTTCTTTTTATATGTTGCGTAATTTTTTAGCCATCTTGGAATAGCCCCGCCCATTACTCCCACAAATCCATATCTACGAAATCTCGAACATTTCCAGAATGATTTGTAGTCTCTCAAACGGGAATATTTAAAATTTCTAGAAAAACCCCATTTTTCTTGAATTTTGGACGAACTTCTGTAATTTCTCAAATTCTGAGAAAAATTTTCATTTGAGTCACCACAAATACTGGAATGCAATCGTAGAAATAGACTTGTGGGCGAAATCAAATAATGGGAAAACATTCATTATTTTTTAATTTTTTGGGGTCACTTATAGCACCTACAATTAACCCCAGAAATCGGAAAGCCAACGTGTCACATCTGACTCATACCCATTCAAACCACACCCAGCATCCACGAGAACACATTCCCGGGGATTCGGTTAGGTCGGATTATTTGCGTCCAAATAGTGAATATTGGCAGGAACACCACGGGCAATCACTGGTGGATATGCTTGCATTTCTGATCCACGACGACGTCCTTCAAACTCCAAGAGCCCGCAAATCGCGTTCTCGTTGTGTACATCACGGGATCCTGATATCATCGAGCTCATTGTCTGAGCTCTGCCACGTTGCACGCGTCACGCATTGAGCTCATTTCGGATGGAGATTTTATTACTCGGCTACGTTCGATCTGCTAGGAAAACTTGAAAATTGGCAAAAAAATACTTTTTTTTTTGAAATTTTAGAACGATTTTTCGGGTGTTCAGAAATATTTTTTTTAGGAAAAAATTGGAACTTTCCAAAAGTTTCAAAAAAATAATTTACAACTTTTTCCTAAAAAAAAAATGAATATTGACAGCTTCGAAAACAGTAAAAATTGTTGGAAAATTTTATTACCGTTAAAAAATTTTTTTTTTTCGTAAAAAAAACTTTCAGTTTAAAATTTGGAGCGTTTACAATTTTATTGATAATTGGTGAAACAAAATAAAAGGTAATTAAAAAGTATTTTTTTTTAAAAATTTGAAAAATTAGATTAAATGTTTATTCTGGGATGAAAAAACCTCCTAAAACCATTTTCTGGAAAATTTAGCGAACTTCCTATTTTGTTAATTCTTTTTTTTCAAGAAAAAATTTTCCACTAGAAAATGGAAAAAAATTGACGTCGTTTAGAGTCAAAATTGGAAATTTGAATTTTTACTAGCCCTTGAAATCGCGCTCGAAAATCGGATTTTTTTTTCAAAGCTTGAACAATTTTCTGCAAATTCTATCTCTAAACTCACAAAAATGATTTATTTCCCGAACATAATTAGCTTTAGCCTGTACTAACTTCTAGAGTAATCAGTCGAATCAAAAAACACTGCAATCGTTCCCTGCGTATCTCAAACTTTTTCCACTGTTAAGTCTTTATCCGGCTAGTCGGATTCCGTGAATTTTGCAGTCTTTTCCCATTCGGATTCAGTTGGTAGGGCGCCTTCCCATAGCTCATCATAGACACTAGTCAGCAAAAAGAATATTCTTTTGAAGATTCGGTATTCCTAATTGCATTATGTAATAACATTCTGGTGTGGTGATTCCGTTATGTGCAAAAAAAAAAACTTATTTATCAAATTTTTTTTTAAAAATTTAATTTATTTTTTTTATCAAACAATTTTGAATTTTTCCCAAAAAAAATCCGAAAATTGTGAACAAATCTTATTATTTTCGTTGAACAAAAAAACAAATTGACACTTTTTAATTAAATTAATTTTCGTTGAGAAAAAGAGATTTGTCGATTTGTGTTCGTCGCGGCAATGATTTTTTTTAACGAAATTTTCCTGAAAAATTCAATATTTCAATAATTCCTGATTTTCTAGTTTTTTGAAAGAAGAACATGTTAAATTTCTATTAATTGTATAACAAAAAATTTCGGGAAAATCTAGAATTAAAAAAAAATGAGAAAAATTCTAGTAATATATTAATTTTAGGTGTAAATTTCGATAATTTTAGGTTATTTTTCAATTTTTTTATGCCGGGCGAAATTTTGATTTCCAAAACAAAAATATGAATATTTCTGACAATTAATTTTCATTCTAGATTTTTTGCACAATTTTCAATTGTTTTCTGAAGAATTTGGTACTTATTGTGTAGTACATGCCCTCATTTTTAAATTAAATTAAATGTTCATTAATTCCTTATAAATTAAACGTGATATACATTTCCTCCTTTTTAGGCTTAAAAATTGCTATTTTTCTACTTAGTAAAAATTAAAAATGAGGGCATGTAATACACAAGTACCAAGAATTTCAAGCCCGTCAATTCTTGTTTTTGAAATCTTTTTTGGGAAAAATTCCATGACATTTTCGCAGATTGTTTCTTCGTTCAGAAAAAAATTTTCTAAAAATTATTTGTTTGAAACTTGGGTCTAAAAAAATATCTCTAGAGCACTTTTTATCCTTTTTCAACTTTTCTGGAAAAAGCTTTTTTATAACTTAAAATGAGTTTCTGTGGCCGCGTTTTCTCTCAACATTTTCACTTTGCGGACAGGGCCACCAAAACCGAACCTGAAATGGCTTTTCTGTCGGAACGCGTGTGGAACATCCGGTGCAACATATGATTTCCGAGCTCCTTTCATCACAACGACCACTTGCTTTTCTGAAACTTTGAGAGGTCATGGCCCACGATAACTTTTAAATGGTTTTCTATGCATGGTGATTTTATTACGGTACCGGGTCTCGACACGATGAATTTTATAGAATAAATTTTTCTGAAAAATTTCATTTTTTTTTTTAGAAAAATCAAATTTTCAAGATACATGGGCAAACATTTTTCAGGAAAAATTTAATTTCATAGAGAAAAATAGAATTTTTCCTATAAAAAAATCTGAGCGTAAATTCGGATTTTTGAGACTCTTTATTTGGATTTTAAAATCCAAATTTTCAAAAAAAAATTTAAAAACCGGAAAATTCCAAAACTTTTTGAGAGTAAACTAGCCTTATATTTTTCAATTAAAATTAATTTTTTAAAAGAAAATTGGAATTTTTAGAACACCAAAAAATTGGCAATTAGTCCCGAGTTCTTCAACGGAAAAATCTGAAAAATCCGAACTTTTGAAAATCTTTAAATATCCCAATATTCAATTAAAAGCGAAATTTCGGATTTTTGAGAAAATTTCAATTTAAAAAAGTCTTCTATTTGTACTGCACACATTTCTAAGACAAATGCATGGCCTAGATAACTTTTTCAGAATAGGCCACCAGGCCATTTGCGACTGACATCTGCCTCTTACCCCCAGTTTGGACCTCTTTTTTTAAATTCATCAAATTCGTCCTTCTCATCGCATATTCCGCATTTGGAATTCGCGATGGCCACATTGGTAGGCTCCGCCCACTTCTGAGCATTTTTTTCTTGGATCCGATCTGTGTTCAGTGGGAGGGAAATTCGAATTTTTTTAGAAATGATTAAAACTGAAAAAAATAGATTTTTTGGGAAGGAACCTGAATTTACGAGAGACTAGTAAAAAGGAGGTAAAACAAAAAATTCGACTTTATAAATTGAGTCAAAAATTAATAGAAAAAATAAACTTAAAATTATGAACAGAAGAACCTACTAAAAAAGTCTAAAAAATGAATGAAAAATTGCAAAAAACATCTTCAAATCTATACGAGACTCCTCCTCCAACAATGCGGTTCACGCGGGTGATGTACCTGAAAAAAAGTGATTTTTTTTTGAAATTTTAGAAAACAAAATTATGAAATAAAACCAAAAAATTTCCGAATAATCGAGATTTTTCGGAATAGTTTGAGGTTAAAAAAATTTTCCCAATTTTTGATGAAAAGTTTTTTTTCCAACAATTCGGAAAACTAAAAGTACCAAAAAATTTTAGTTTTTTCGATTGTTTCAATATGATAATGGTTTTTTTAAATGTTTAAAATTGTATTTTTTCCAAAAATATTATCAATTTTCATACAATTTTATGGTTTGGAGATTTTTTTCAAATTCAGACCAAATTCGATATTCGAAACGTTTCTCGAAACAAAATTTTTCAACTGAAAAACTACAAAAAATCCTCTTATGGATCTTTGAAGAAAAATCGATATTTTCTCAAATTGTTCAGATTTTTTCTGTTTTTACCCAAAGTGCCCAAATTTGAGTTCGCCACGAATGTTTAAAATTATTTTTCCCGTTTTTTCGATATTTGCGGGTTAAATTTTTTTAAATTTGATTCAATTTTAATAAGTTTGAGTTTTTTTACGATTTTTTGTCCTAATTTTTTCCAATTTTTTTCCATTGGTAGAAGGCAAAAAGTGCGATTTTTTTCCTTTTAAAAATAATTATTCAGTTTTTCGACTGTTTTCTTCTCGCTTCCAGATTTTAAGTTCTCGAATTTTTTTTATATTTGAATTGTATCTTTAACTATTACCTAACGAAAAATTAGTTTTATTTTTAGATTGGAAAAGAACGTTCTTTTTCGTAAATTTTAGTGATTTTTGATTCCAAATTTTTGGATATTTTTCAAAATTTCCCATAGAGAAAGTTTTACCAGGCTTTGGTAGAAGCCAGAAATCGATTAAAGCTTTTTTGGGTTTTTCGACAATTTGTCAAGTTAGGAATTAAACTTTTAAAATTTATTTCAAAAATTTTAAAAAACTAAAAGTATTTCTGAGAATTTTTCTGATATTAATTATTCAGTTTTTCGACTGCTGCTTGCTTCCAGATTTTTTCTCGAAGTTTTTATATTTGATTTTTTTAAAAAATACTCTATAAAATTCATTTTTTTTAGGCATTTTTTCTGGATACTTTCTCTTTTCGAAATTTTCGTAAGTGTCAGTGTTTTTCGATTTTTGATTCTAAATTATTGGATTTCTTAAATTTTTTCGGAAAATTCTACCTGGCTCTGGTAGTAGCCAGAAATTATTGAAGAAGCTTTTTTTTCGATTTTTTAGACAATTTTCCGAAGTTTTAGTTAGGAGTTAGACTTTTTCAAATTTTTTTTCAATTTCAAAAACTTTACAAACAAAAAGTACTTTAATTTTTGCGAAAAACAGCATTTTTTTTCTCGAATATTTGAACTTTTTAAATTTTTAAAGCTTGTTTTATATATATTCGAGTATTTTACTCTTAATCAATGAAAAATCTTTTTTTGATAATTTTTTTCAAAAATGTAAAATTCGAATTTGAAATTATTTTCATTCAGAAAAGGGAAACTATTTGAAAACAATTTTTTGTTGAATTTTTCGTAAATTTGAGTGATGCTTTTTGATTCCAAATTTTTGGATTTTTTTTTGAAAATTTTCCACGTTTTGGTTAGGAGTTAGATTTCTTGGAATTTTTTTGAATTTTTTTCCAAAATTTTAAAAAAGAATTTCTGAGAAGTATTTTTTCCTTAAAAAAGAGGAATTTTTTAGTTTTTCGACTGATTTGTGCGTGCTTCCAGATTTTTTCTCCAAGTTTATAAACTTAAATCTTGAAATTTATATTCTAATATTTCAGATATTACCTAATCGATAAAAAACTTCGTTTTCTTTTCAAATTTTAATTGAAAAAAATCGATTTTTTCGATAATTTTTTAACGGCTTTTTTTATTCGAATTTGTTCAAACACTTTTTCATTCAGGAGAATTTGATTATTTGCAATTTTTAATTTAATTTTTTAATCCTTTAAATTTTCGTAAATTTTGAGTGTTTTTTGATTTTTTCCAAATTTTTTTTTTGCAAATTCTCAAAATTCTTATTTTTGCAGAAAATTCTACCTGGCTTTGGTAGACGCCAAAAATTCGATTTAAGAAGCTTTTTTTTGATTTTTTTTGACAATTTCCCAGGTTTTAGTTAGGAGTCATTTTAAACTTTTTTCTTTTCTTTTGACTTTAAAAAAAAGTTTAAAAACTAAAAGTGTTTCTTAGTTTTTCCTTAAAAAAGAGGATGCACATTTTTTTCGCTAGTTTTCCTGATCGACTGACTTCGTTTTTGAATTTTTAAAAATTCAACAAGTGTATTTTTTAAAAATCTAACCGATAAAAGAGTCGTATTCTCGATTTTTGTTTTCAAATTTTTGGGATTTTTTTCAAACATTTTTCCAGAAAATTTTACCTGTCTCTGCTAGAAGCCGAAATGTGTGATTTTTTTCCAAAAAAATGCTGGCTAGTTATTTAGTGCTTGTTTCTTTCTCGAACGTTTTATTATTTGAACTTTAAAAATTTTTATATAATATTAAAAATTTAAATAATAATATAGAATTTTTTTGAAAATTCCTTTCTGATTATGGAAAAAACATTTTGTTATGTATTTGAGAAACTGAAATTTTCTGAAATCTTTTAAATTTGGAAAATTTCGAATTATTTTTGTTGATTATACTCTAGGTAATCGATAAAATTTTTTTCCAATTTTATGAAAAAAATGATTTTTTCGATAATTTTTGATTTATTTTCGGGAATATTTGAAAACAAACACTTGAAAAATAAATCAAACTTTTTTTTTGAAATTTTCGTATTTGAATTTGAGTCTTTTTCGATTTTTGATTTTTCTAAATTTTTGGATTTTTTCCCTCCAAATTCTTCGTCAATTTTTAGAAAATTCTACCTAGCTCTGGTAGAAGCCAAACATTGATTTAAGAATCTTTTTTTTTTCTTGGATTTTTTTTTGAAAATTTTCCAAGTTTTGGTTAGGAGTTAGTGGATTCCCTCAATTTTTTTCTTGAATTTTTTTCAAAAGTTTTAAAAACTGAAAGAATTTCTAATAGGAGATTTTTTCCTTAAAAAGGAGGAATTTTTTAGTTGTTCGACAGATTTCTGCGTGCTTCCAGATTTTTTCTCCAAGTTTTTATAAAATCCTTAAAATTTATATTTTTAAATAATATTTCAGATATTATACTCATAATCGATATAAATTCGTTTTTTTTTCAAATTTTAATTGCAAAAAAATCGATTTTTTCGATAATTTTTGAATTTTTTTTGGGTTACAAATTCGAATTTGCAATATTTTTCATTCAGAAAAATTTGATTATTTGAAAACAATTCTTAAGGATTTAATTTTTTAATCCTTTAAATTTTAGTAAATTTGAGTGTTTTTTGATATTCCATATTTTTGGATTTTTTTCCAAATTCTCCGAATTGTTATTTTGCAGAAAATTCTACCTGGCTTTGGTAGAGGGCAAGCCAAAAATTCTAAGAAGCAACATCAGACGGTCTTCCAAGTCTTCCCAACGGAATCATCGATTCCAAGTGTTGTTTAATCTGGCGAGCTTCTTCTCCAGAAGCATGATCCCATACAGCACCAGTTTCCTTTTCAATCATTCCAGACACCACACTAATCACGCGGACTCCTTGTTTCGCGCACTCGCTACGGATTTTGTAAGTGGGACACTGCTAGATGCAACTGAGTAGAGGGACCCATATCGATTCATGGAGTGAAGCCGAAACATGACGTTAGGTAAATGATACTGCCGTTTCTGTAAAAAATCGATTTTATTTGGACGGGAAATTTTGCCTGCCTACGTGCCTACCTGCCGGCCTATTAGCCTATTTTTCATATTTATTTTGTTGTTCTACTTTTTTGCCGTTTTTTGGGAATTTCATGAGTTCTCGGGTCGGCACGACTTCATGCCCACGTGCCTATCTACCGGCCTAACATGATATTTTAATTCCATGATTTAGGTAGGCAGGTAGGACGAATACCTGCCTGCCTACCGCTGTTTTTTTGAAATTTTTTTGTGTGAAAAATTAAAATTCAAGGGAATGCTTTTTTTTTCAAAATTCAATGATTTTTAATGCAGACCGCGCCTATCTGCCTACCGCCTATTTTTGGCATTTTTTGTGTGCAAAACAAAATCAAATTGGAATAGATTGCCTTATCTTTTCGTTTTTCTAATCTGTTTTCCATTTCAAGATTTTTCGGATAGGCACGACTTCCCACCTACTGTGCCTACCTACCTACCGCCTATTTTTGGCATCCGGTTTTTGTGAGTAGCAAAAAGAGATCAAATTAGCTTTTTCTCCTGTTTTCTCCGATTTTTTTGGCAATGTAGGCACGACTCCATGCCTAGTACCTACCTACCTACGTCTCCTATTTGTCGGCATGTTCTCGTACAGAACATAATCAGATTTTGAAAACACTAATATTTTTGTTTTCTGAATTTTTTTTCCAAATTTTGTGATTTCTAGGGTAGGCACGGACTTCATGCCTACGTGTCTACCTACCTACCGCCTATTCTCGGCCTTTTTGTGACTGAATAAATTAACATTCTTGAAAATCCTTTTTTTGTTCCCTTTACTTCAATTTTTTCAAGTTGCATGTTCTCTAGGGTAGGCACGATTTCATCCATGTATCTACCTTTTATCCCCCTTTTTTGGTTTAGGTCGGCAGGCTTGAGTCAGTGATGCACGAAAATCTAGAAACATAATTTTGATTCTGTACGGTAAATTAGGCTTTCAAGACAGTTTGAATTTCTCGAATTTCTACCAGCAAAAAATAATATCTGAAATAACTTTCGCAGCGAGCCCCAAGAAACTGACTGATGGCGATAGCGTCGACATAGCGGCTTTCGAAAGACGGGAACGGTGTTGTCAGATTGTTGGCGAAAAGCTGAAATTTCGAGGTGAATTTTCCACGTGGAATTTTCAGCACGCTCGAACCTTATCAAAATCCTCGCCGGATGTCTCAAGAATCTTGCCGAGCACCTCATTCTGTGGTGGAACTGTACTTAAAGTGTCCAGACCGCCGAGCTTCTCAGCCACTTTCGTGATCAGCTTCCGGTCTGTCCTCGGCTTTTGACACGTTGAGAAGGCTGTGACTCACCTCCAACCTGAATTTATTCCCGAATTGATTCATTGTCAAGTTCTGAAAATCTTCCTAAACCTTTATATTGTCCTCTCCTTTCCCCACTATTCGGACAGTCTGCGGCGGCGGCGACCTAGTAGCCGGTGAACGCGAGTCTTCTCACTACGCTGCTTTGCCCAGTGTGGACAGCAGTTGCCCCGGTGCTTACGAGTGCACATGACATTACTCTGAAAGCCCGATGATGTGGAGGCACATTTATAGATACACCTAGACATCAGGTAGATTTATTTGGAAATCCGTAGAAAATAAAGATCGTGATAAATCATTTTATTAGAGGGGAGAGGGAGGGCGAGCAAAGGAGATCGCTGACAACTTTCGAAAACCGGTTATTTACTCCAGTTGGACGGCTTATTCATGCCATATTTTCCAAGTTATTTACACTATTCTGTTGGTATTGAGAATGTTGATTCTGCTTAGCTGGCGGCTTCGAGCTAGACATCTTTGTAACTCGCGCTCGTCATCCTTCCGTAGAGTTGACGACCTCCAGCGCTGCTTCCAACATTCCGGGGCATCATGTTCATGAATGTAGTAGGGAACTAGTAGCAGGTGACTAAGAGCCTGCTCCATGAACAACGGCGACAAGTTGTTGGCTGCTGCATATAGTTCCTGGAACCCTGGTGGTGGTCCAACATTCGACGCCTGCTGTGGCAGCTGATCCGGAGAGCTTTGAGATCCAAACTTATTGAAGTCCAGCGATAAATCCTTGAGTCTCTCTCACCAGATTGCACTTGTTGCGCAGAAGCAGCCTGTGACAGACGAGCAGTTCGAAGCAAGCTTGTAAGATCAACTCCCATTCCGTATTGCATAAGAGGTATATTGCTCATCACGAACTCCTGGCACTGGATTGTACCTGTTCATGTAGTTGTTCATGTATGGTGCATATGGGGGTTCTTGAGTGAACATCATGATGGGGTGCTGTTGTGGATTTCCAGTCGGTTGTGATTGAGCTGGCGGAGTTTATTACTGCTGCTGCACTGGGCTGTTGTGGGGCTTCTTGCTGCTGTGTGGCTGGTGCTGCTGAGCAAATTGCTGTGTTAGAAGTCTGGTCCAGAATTGTTGAACTTGCGGCGCCATCCTGTCCGTTGGTACTGATATGAAGCGGACGAAGTGTCCTAGGACAATCCTCAGTTAGATTGACCATAGGAGAATGGAGATGAAGTCGATTTTAAGTGTAATCGCCGTCAGGAATTGACGTCCTTTCTGGCAGAAAAATAATCGAGAATTAGAAATCGTCTTTGCAACAAATTTAACTCCCTCAACTTGTTTCGGGATTATACGAGAAGAGTTAAATATATAGAATTTCACTGTGAAATCGAGGCAAATAGGCGGAGGATTCAATAGAAGGAAGCTGTGGGCTTGGAGCAGCCTCAACAATACAAATGAGTAGTCATGAATGTTCGTTGGTGCAGTTGTGCGAACAAATTCCCCTACAGGATCAGGAATAATCTGGACTGGTGCTGCACTGGAATTGGAGATAATCCTAGTCCTGGTGCTTCACTCAGATCTATTCCTAGATCCGTCCTCAGTTCAATGGTCCATGCTTGATTAGGTTCTGGGGTGCTTTGTACATTTTGATCGTGATGAGTCGACACATTACGCGTCTGCTCCTCAGCCAAAACTGATGATTCACTGCAAATTAAATTTTAAAAAATCTAAATAAGTAAAAGGACAGAACAACTTACTTTTTGAGGAAACCATCTTCATTCTCCGGCTGGTGCGAGGGTTCTGGCTCGAATGCAAATAAAGGCCGGCGCTCTGGCTCTTCTTTAACTGGTGCAACTGATGGAAGTGGAGGTCTATATGTGAGAGACTCCTTGGCGGAGCTGCTGGTTGAGGATTCTGTGCCTGGTACTTTCGGAGTGCTGCTTTGCGATGGGCAGGTGCTGCTACTGCAGCAAATGAGATCGGTGCCGGCGCAGAAGATGTGGGAACAGTGGCGCTGACGGGAAATTCCTCTACTGGTGGTTGTACTTCTGTGACTGTCTCCACTTTAGTCTGCTCCTGGAAAAAAAACACGTTTCGTCATTTCCTTCTTCAAAAAATTCTTACCTCATCAAGATTAGCCGTCTGAGCGCATCTGGGTCAAGTGCTGATGATGGAGCAACAGTTCGGGAATATCCACCTCTGGCGCCACCTCCACGTGCTCGTTCCCACCAATACGGTTTTACAAATCCTCCTCGAGTCGTCCAGCGTGGTGCTCTGCTCCTTCCTTCATTATATCACGGTTATCCTGATTATTATCTCGACTTTCTGGAGCTCCATTGGATCGCCCGCGGCCTCCTCGATCGTCGAAACCGGTGACTCCACCTGAAAAAGACATATGAATATTTGATCTATTTAAGCACGAACCTCTGCCTCTTGCTACAAATCCTCTGTTGTTATGACTGCCCTCTTCCGGCTTCTTCTTTTCCTTTTTAGCTCTTTCTGTTCTGTGCACGAGTCAAGTTTATCTCCAGCATCCAGAATGTGATCGAAAGTGTTGCGCCGTAAAGATTGTTGTCAGTATCCAATAGCTATCTCAGCTTTTGCTTGTGTACATCCGGTGGTTTTGATAATCTGAAAATGAAAAAGGACATGAGCAGTCTGAAAAAACCTCTCTTGGGAATGCGCGAACACTTTAATTAGCCCAAATGAGTAGGGCATGTGGGTACTCTTACTCTCGCTGCACCATCTCAAGCGCGCCTGCTTTTGTCCTGTTCAATTTGCCATCTGGCCCCGTCTTATCGATTCGAAATTCCTATTGACACTGCAAAGCGGACACTAGAGAAGTTCAGCCTAAACAACAAAGTCACGTGCGTCATCATGTCGGTGTGTGTCGAGCGTTAGCGTGAGTGCAAAGATTCACTATTGAAAAGCGTCATTTCCAGCTTGGAGACTTACCATCTTGATCATAAACTGTATGTCCTCCTCATTTCCGGAATTTCCTTCTTCAGTGTCGTAGGGGGCAAGTCTGATCGCTGGTAGCTTTTTTGTCGCCTTTAATACCCATTCTGAAAACAAATTATAAATAAAAAGGGTCAGTCATGTGAACGCAGACTGAGAACTAGTTGAATGAGAATCACGTCTTAGAATACAACTATCAAAGGAACGTTGAATGAAAGGAAGCAAATAGATGACACACCACTAGTAGGACGAAGAAATATGGAACCTTCCATCACAAAAACATTATCAAAAGAAAAGCCTCGTACAGAAGACTCTAACACAACATGAATATATCAGTTCAGCAATACATCACGTTACGCTTTGGAGGATATTCTAGAGCAGAAAACCCCGACTACAAAAATTTCGAAATGGAAAATTCGAATGAACTGCTATACAATGGAGAATCCTATTGAGCGATGATAAAGTGTAGGTGTTACTAGATTGAATCAAAATTTCGAAATGTAACAATACATTGAGTGAAAATTTGGGTATTTGCAGAGTGTGTATCACAGCGGTAAAATCAATGTTTCCACTAAACTCAAAAGTTCTTACGCTGAAAGATCAACATTAAAAAAGTGAATCACCGCAACCTAGACGAATCGCGTTGCCGTCAAATCTCGCAAATTCCCGGAGTTGAAAATGCAGTCGACCGCGACGCGAGCGGCAACGCACCCCGACCTCCAAGCGGCATGGGTCTCGCCACGACCAAAAGTACGACGACAGCCTCTATCTGGCAGTATAAAAGGCGACCATTTTCCGCTATTTTCCGGTAAATTTTGCGATCGAATGAAACTGTGTTGCTGAGGGGGTGCTAATTTTCCGGAAGTTTACCTATTTAATGTAAAAATGTGAATTAAACAAAAGAAAGTGGGTAGGATTATCAAGGAAACACACTGTTCTGGGAATTCGATTTTGTGTATGGACTCTTATGGCGTCAACATTATCGACACGAACACTCAACACCTTGTCACATTTCTGAGAGGGAAATATCATTTTCAACATGAGTCTTCCCAGTTCATTTCGACTCGTCGGTTCAGGTAAAGGCGATCGGCGAGCGATCAACCAGGAGCACACCAGAGCCGGTAATTGTTCTTTTTTATTTCAAATTTCTACAACAACAAAAAGAATTAACAATAAATTCCTTTGAGGCCCCTACCCACATAAAGTAGGAAGTCGACTACCAAGATGGTCATCAAATGGCTCCGGAACCCGTGGAAGCACCAATGTATAAAAATTTAAAAAAGTTAGAAAAAAAATCTGAATCCCAATTTCCAGAGGCTCAAAACGATGAAATGTAGCCACCTCAACCTAACCGCAGATGCAGAGAAGCATTTTAGCATAGCCAATGGCTCCCCACAAAGGCCGCCCTGGACTCCACTAAACTCTGCAGCGGCGGCCGCCGCTGCTTGAGATGACAAAAACGTGAAGGGAATGCGTCCGCTTTCTGAAAACTTTAATTAATGTGTCGAATAACGATGATCCAGAAATGTCGGACAAGGCCGCACGTCTCAAAGAGCTTATTCGAGTGAGGAATTGAGCGAAAAACGCGATAAAAACCGGACAAATTCGGATATTTCAGGGTGATTTAACTGGAAACGACGGCTGAAGAGTTTACACGAAATCTGCAACAGATCAAATCCCAGGCTCAACCGCATCTTTTACCTTGAGAATACTCTTCCGGCAAGGAATGCTGTTCGAAATGGTTCGGTTTTATGTGCAAAAAAATTAAGATCGCGCATATTCAAAAAAAAAATTATCGAAAAACAGGTCGAGTAGCATTGCGAAAAACTTGAATTAAAGGTAACATAAAAAATTGCAGAAAATCCGTTGAATTACATTTTTCCAGATTGTCTGTAGAAATTCCATGATAAAAATTCAAAATTTCCAAATTTATTGGCTATTTCTAGGCTCAATTTCATTAAAATTCCATTTTTGATAGCGAAAATTATCAAGTTTCTAACAATTTCAAGCTATGTTTTTGGTGATTTTTTCAATTTTTCGGCTTTGAAAGTCCATTTTCCGGATTGTCAGAATATATCCGAGTTCCACAAAATTGAGTAAAAAAAATTAAAAATTTCCCTTTATTTAAAAATATTTTCAGCTGTCAGTAATAAATATGGATTTTCCGCAATTTTCTCACAATTTTGAGCAAATTCCTCAACCGATTTTCAGCCAATTTATAAGGATTTGCACCCAGGGGGTTGTCATAATTTAGGGTTCAGCTGAGAAATTAAGTAGTAAGTTTCTGAGAAAATTTTTATAGATTTTCTCAAATAATTTCAGCTCAAAAATTCGATTTTCAGAGCGCATTTCCAGGTTTATTAAGATTTTGCCACCAATTCTTTTAGCTTAAACTTTAAATTTTCCACATTTTTTGTCTATTTCCAGTATATTTCTTTAAAATTCTATTGTTGAAAGCAATAATTATCAAGTTTATCGCACTTTATCAATTTTTCCGCAGTATCTTTTTGTGATTTATCCAAGTTCCACCAAAATTGAGCAAACAATTATTTAATAACTTCCCTTTATCCTCTTAATTTCCACAAATTTTCTCGCAATTTACACGCAACTTTCATAATTCAGGGCTATTTTCAGCTGAAAAATTGCAATTTAAAGTTTTTAAAATGTTTATAGATTTTCTCAACATTCAGCGTCAAAAATTCTATTTTTAGAGGCGCATTTCAAGGCAATTTATGAGGATTTTTAACTATTTTCTAGATGAAGAATCTTTTTTTTTCCTCTTGGACTATTTTCCCTTATTTTCAGATTTCCAGCACTGCATCAGTTGAAGGCGTAAATCCACCGCCTGGCTACGTTTGTCAACAATGCAAGAACCCCAGGACCCCCTCAGCCACCGACGTCCACCTCAACAACAATCCCAGCAGCAGCCACCACTAGAAATGCGTTAATCCGAATCAAATACCCCCACAAATGGTTCAAGGGGGTCCCCATAGGGTTGTAGGCGCCCGGCCAATGATCAGGCCTTCGAATGGGCCGCGGCGGCCCTAGCCCGGCCTACAATGCGGCCCCGTACGAGGGCCGATGGGACATCAGATGGTCCAGATGCATCCTCCTCCCCCACCACAGCAGATTCAACAGCAGCACCCGGCTCCCCCTGTAGAAATGGAGGTGGAAGAGAATTTACAGCCTACCGCGGCGAGGGACCGACGGCCAGCAATATAAGGATCGCTCAAACCGTCGCTTCTGAAGCGGGATGAGGTGCGGAATAGGATCACGAAACGAATGATGTCATCGTGTTCGTGGAAGAGGAGGGTGCGCTTGTCGCGATTTCAGCTGTTGAGTCGCATTAACTTTAAGGAACTTATTACACTGATGGCGTTGCAGAACATCGGGTGGAAGAGTTTGAGGTATTGAGGAGAATTGATTTTGCTTCAAAATACGGCAGCGAAAACAGCAAAAATTAAGGAAAAGGAAATTAAGACGGCTTAACAACAATTTTACATTAAAAAAAAATTTAAATTTCAAAGGTTCCGAACTATTTATTAAAAAAACATCTAGATTTTAAAATCCAAACAAAGTGAAATTTACGCTGAAACGCGTTAATTGTTTTTCAAAGTCCCAAAATATAAAAATCTGAGAAATATTTTCAAAAATATCTCCAATTTTCCCCAGATTCCGAATATATTCAAATTCAAAAAAAAAATTTCACCTTTATATTTCAGCTTGAAGCTATTCGCTTTGTGCATGCACACCATGACCGACAAATTTTTTCAAATGCGCGCCCAGATAAATAGCTTCTCATCGGGGGGCTTACTCGCTTCGTGTCGATTACGAGTTCATTTTTTAATTTCTTTTAAGCTTTTTTTTTCAGTTTTTCAACGAGTTTCATTGAAGATTCTTCGTCGATTTTTTGTCATTTTTTGAAATTTTGTTTTGTGTCAATTTGACACTTTTTTAGGTCAAAACCCCTGTGTTCGTCGATGACGTAAAAATATAAAATTCCGGGACTTTGTTTGGAGATATAAAAAAAATATTTTAAAAATTACGCACAAAAAAAACTGACAAAAAAGCATAGACAAAATAAAAGAAACGAAAAAAAAAAAGAAACTGTAAAAAAGCACGAATAAATTTTTTTAAATAAAGGAGAGCTGCCGTAACCATCGACACGAAGCAAGCATAAAATGGCTTTTTTCCTAACGATTTGTGAAAAATCCGAATTTTCCATCCTAATAAAAAAGCAGAATTCCGGAGAACTACGTGGCAATTGATGACGTCAAACGGCGCGTGATTAACTTCGCTTCCTTGAAGATTTGGATCGTCAAGAGGAAGAATTAAGGGAAAGTCGAGAAAAAGAGTCGCTAATTCGAATGAACAAGAATAAGAATAGTGGCAAAGAGACGATAGAAAAAGCGAAAGAAATGCAACACAGGAGATGCAGAAGCGAAAAGGAATATTCGAATGCGGCTGCAATTAGCACTTTCCAGTAATCTAAAACTGTCAAGAATAAGTCCGTTTTGAGCGTGAAATGTTCAAAATTAATTATAAAAAATAGATTTAAAAAAAACAATTTCCTCACCAAGGGCCGTGTCATTTTTCGATTTTTCGGTCTACAAAAATTCGAAAAATGAGTAAAGTTTCGTGTTTCGATTAAAAGTCAGAACTGAAACACCGACACCTTTGTTTCTGAGATTTGGATTATTGGAAATGAGCAAAAAAAAATTATTCAGAAAAAATTGTTTTACAATGCTGAAAAATCGATGAAAAAATAAAATAAATCAATAACTAATTTAAAAAATGGAGAAAAATTTCGATTTTTTCGTTTGTATTTCACAAAAAAAAATTTTTAGAGATAAATAAAAATTTGCAATTAAAAAGAATTACTATTTAAAATAAAAATTGAAAAAAATAGAAAATTCAGAAAAATAGCGAAAAATAAGTTTTTTTCCAGAAATTTCGTTAAAACGATCAAGATCTTAACCCTAAAATTTAGATAAAATCAATTTCTTGTGGTTCTTAATTTGAAAAAAAAAACAGTACTTTCCATTAATAAATCACTTTCAAGCGAATAAATTCGTTTTTATTGCGAAATTCGCAAATTACGAAAAAGTGAAAATAGAAGCTGAAAGGAAAGAATGTTTAATAAAGAATATTTTCGGCATTAATTGGTTTTTATACATATTTTTTTGTAGAAGTAAAATAATTACTAAAATCAGTGAAAATATTGAAAAAAATTTTAAAATCTGGAAAAAAAGCAACAAAAACTTAATTTTTCCAGAAATTTCGTTGAACTATTCGGTATTTTAAGCCTAAAATCAAGATACAATCAATTTGAACAAAATTTGCATGCTTTTACTAAAATTAATTCGGAAGAAATAGGAAAAAAAAGAAATTCTCGGAGAAATTTGAATTATTGGAGAAAAGCTGAACACTTACAAAAAATTTTTTACTCCGTTTTGAGAAAAATTTTTGAATAGAAAAAATTTTAAATTTTTAGAATTTTTTAACTATAATTTTTGAATTTCAGTGACTTATAATCACTTCCAGAAAGACAATGAACGAAAAACAAATGCTTATCGGCAAAAAAACGTATTCTTAAAAAAAAATTTAAATTTCTAGTGACCTTGAAAAAAAAACCACATTTTCCAATAATTTCCAGGAATAAACTAAATTTCTTTGGAGAAATTGGAAATTTATTTCACATTTCGAAAAAATTTATATAGAAATAAAAATTTATATGAAAATAAAAAATTTGCAGCTCCTTACAGCAATGAAACCTGTCATTTGTTGAAAATTAGTTTTTTTTTAATTTAGAAATTCTCTTTTCGAAAAAAAAGGTTTTTTTAAAACGTGATTAAAAATTAATTCATTCATGTCATTTTTCGCCAAAATAAGGGAAAAAATAATTTCTAAAATTAGACAAATACCTTTTCTGTTGAAAAAAACAACATTTTAATTTTCTTGTTTTTTAAATTGCTTCCACTAAATTCACTTTTTGAAGAAATGTTTTGAAATTTTTACTGAAAATTGTTGGAAAATTATTAAATGTGCATTTTTTTGCAATTTCCAGTTGATAAACTAATTTCGGTTCAATTATAAAATAAATTTTGAAGTGGAACCAATTTCAAAAAGATACATTTTTTACAATGTTTGTTTTTGTTGATAAAACGAGCTTGTTTCTACATACCGCTTTTTTACATTGAAAATAAATTCAGTCAGATGGGAACACACGGGAGCCGCAACGACGCACCTCGTCCACGAACAGTACGTGTAACAACCAATCGTGAACTACATCTTTTATTCACGGCATCCGGATAGCCGATTCACAGGGTAGCGATTTTTTTTGTTTAAAAAATTTAAAAACACCGTATTAAACATTTCATTGGAAAATACTGATTCAAAAAGTTTTCAAAAAACTTTCAAACGAATGGTAGTTTATTTTAATTTTAAAAAATTCCAATAAAAATCAATTTTTATACGATTTAAAATTTTGAAAAGTTATCCCATTCGCTTCTCCTAATAAAACTCATTTTTTTTCCAGAACATTCATCCGTGAAAAGATGTCATACGGTGGTCCGGTGACAGTCGGTACAACTATCTGAACTAAAGAAATCTCATGGAAAAAGGAGCGAAAATTCTGCTTTCGCTTTTTCGTTTTTTAAATTTAATTTTATTTTTCCACAAATTAATCACTTATTTCCAGTCAAATAATAATTAATTTTTCATTTTTAAACGAAATGCTAGACATAGAAAAAAGCTTCTTTCAGCAGAGATTTGCAGCCAAAAATTTCAGATTTTTCACGAAGAACAAATTCAACAGCTAAAAATTGGCAAAGTGCAAAAAAACCAGAATTAGATATTAAAAATACAGGAAAAATCGAGAGAGTTACAATTCAGAAAAGTAGGCAATTTTTTTCAAAATGTCTCAAAAAGAATATTTCGGTATTTTTTATTGTCCCTCTTCTTGAGCACTGAACCTCGGCTCGTGTTGCACCAATCGAACATTTTGAGCGTCGGTGGAAGTGGAAGCTCATCGATTATTCGCGATAGACACCGTCGGCACCGGCGCCAGATTTCTACGGGCGAAGGTGGATGTCACGCGCTGGAAAAATTTCTAATTTCGAGCTGAAAACTCTTTATGAAAGCAATATTTCATAGTTTCAATTCAAAGTTCGAATTCCTCGTAAAATTAGTCGGAAAACCGAAAACTAGAAGTAGGCTCTTGCTCTTTGAAATCAAGGCGTACGGTATCCTCGAAAGTACGCAAACACCGAATTTTGTTTGTTCTTTTGAAGTTTTGGCGCCAAGAACACAGTACGAGCCGGGGTCTCGACACGACAAATTTTTAAAATTTTGAGGACCCTGTAATTTCAAACAAAAAAAGGTTTTTTTCGAATAAACTTCGAATGATACGATAAAAAACATATTTTAATAAAAACCTTGGCAACGAAAGTTGAAAGTACAGTACACTCTTCAACGGCGCACACCTTTTACGCATTTAACTTCCGTGGCGAGACCGGATGTAATTTTTGACTAAAAATTAATCGATAAATCCGTTAAAATATTATTAAAAATTTTTAGATATTTTTCAAAAAGACTGTCGAAAAATTGTTTTTGCGGTTCGATAATTTTTCAGAATATAAACAAACAGTTTAAAAATTCCAACAAATTTTGTTTTTCATACCGAAAAGAAGAAAAATGGACAAAATAGTAAGCTATTTTTGTGTGTCAAAGTGTCTTATTTCGTCTTGATCTGACGTAGACCGATCTACAAAAAATGCGGGAGAAGAGACTCAGTTTGGATTTCTCAACAGAGTTTCGCATGGTTAAACGAACGTGCTGACGTCACATTATTTTCAGGCTAAAAAATTCCGCCTTTTTTAGTAGACCAAACCGTAATGGGACAGCTTGGCACCACGTGACACCGCCCGCTTCTCACCTGTTCGTGATTTGGGAGGGCGAGCTGCCAGTTCTTTCGAAATAATCGTCTAGCGGGGGACTCGATGCCGAAGGAGTAAAAATGTTTGATTCCAGTTAGAGGAGCATTCTGACACATGCGTATTGCACAACATAATTGACGCGCAAAATATCTCGCAGCGAAAACTACAGTGATTCTTTTTAAGTGACTACTGTATCGCTTGTGTCTTTACGTTAGGCATCGATAGAATATTTTTAAAAAAGAAGAAAAAAGAGGGAATGATACGAAGAAAAAAAGGAAAAAAATAAATGCATTTATCAGAAATCGAGTTCGTAAATCGAGACAATCGGTACTGTAGTCATTGATTAAAGACATCCTGTATGTTTTCGCTCCGAGATATTTTGCGCGTCAAATATGTTGTGCAATACGCTTTTTAAGAATTTCCAGTTTTTTCAAACCTTTAAATACATTTTCGCGGTTGTGCTCTCGGATTTCGGGGAACGTATACGTGTATCCGCGACGTTGACGGGGTTGAAGCAGGGTCCGTCGAACACCCTAGCTCTTCGTCTTCCGATACTTATTCTGTTGATGTTGACGGTGATTCCTGCTAGGTTCCTCTAGAGCATCTGAAAGCTCTTGCTCATCTTCTGATAAATCTCGATTGGGGCGTTCAACCAGGCCGGTGGTGGAAGGATCCTTGATGAATCATTACAATCTCCATTCTCGGAGTATTTGGAGTTTCTGGTCGAGCTATATCGAGGCCCCAAAGTATGCTTCTGATGATGGCGGGGTCTATCATGATTAATCGTCCATTCGAGCACATATGCTGGTGCTGGAAGGATTGAAAATTGTAAAAACTAAGTTATCGATCTTTGGCCAAAAAAATAATATTTTCTCAAAAATTTTGAAATTCTCGACAAATTTATTTTCACTACTGCCGGTACAGAGAAAAATTGTAGATAGTTGAAGAGACACAGATATCCCGGGAACCAAGGGACGGGGCGGGGGATGTCTGTGTCTCTTCAACAACCTGCACTCTGTGCAATAATATACTTTTTCCAAAAAAAATACATTTCAGAAGTAAAAATGGACAATTTCGGAGTATACACAATTGGAAATTTTAATTTTTAAAAAATTAAAAATTGTTTTAATTCGGAGTTTTAGACGGAAACAATTATTAAACTCTAAAATTTTTAAATCGAAAAAAAACAAGTCTGAGACTGAAAAAAATTTCGAATAAATTTTGTACTGAACAGTATATATTTCGATTTTTTTTTGAAAATCACATTAAATGTTTTCTCGCAAAATTCGGATTTTTTTTACCTGCTCGATTTTCAGTAGCCAGAGCTGTATTTCCGAGATTGGCACCATCCAAATGTGCTCGGGGCGCTGCAATTTTGACATAAAATTTCACTAAAACGCCAATTACCTCGGTACTTATACAAATTTGCTACTAGAAAGAAATACTACTGTTAAGATAATCGAAAGTTTGGATTGACAGAAATCCAATGTTTCAGCTTCTAGAACCAATATTTTTATTTAGAAAAAAACTTCCAGAAAAATGACTTAATATTTTTTTTTAGAACTTTTGAACATTTTTCCTGATTTTTCTTTTTTTTCCATGTTTGGAACTTGCTGGGAATTTCTCTTTTACATTCCTTCATCCCACAGCTTCGCTTCCTAGGCCTAAGCCTGAGCTGAGCCTATGCATAAATCTAAGCCTAAGAGCCTAACCCTATGTCTAAAACAAAAGCGTGGACAGGCCCAAGTCTAACTAAGTCTTCAAGCCCACGCTCAAATTTAGATCGACTCAAGTAACTACTTTAAAGTTGGCAGAGATATTTAAATTCAAAAAAATTTTTAACGCAAAAAAAAAATACATTTAAAAGAAATTGTTTTTTTTAAATAAAATCTTCACCTTTGCGTAAAACCTTGGATTTCGGTCTCCAATTGAACATTTCTTGAAGGACGTCAGTTCTTGTTTCATTCCATCGACGGACATGATCTGCTATAGTATTTCGAATATTTTGTATTGTTTGCCCTTCTTGTACTCTGGGATGACTATTATTACGACCCAAATATTGATCCATACGTCATCCAAGTGATTACGGGTTCTTCTACTGGGAATGTATATAATCACTTAATTTAAAACATATTTTTTAGTTTATTTACCTTTGATTCGAATTAAAAAAAAAAAAATAAACGGTTAAATCCTGACGGGAGCCAAGAATTGGGCGTGTTTTAGGACGTACTCTTCACTTACGCTTTGGTCTACAAATGCGGAAGACGTTTGCCCCAATCACGTCAGCACGTTTTTAATCATGCAAAATCATTTGACTGAGTTCTGCGTCTCTCCTCCCGCATTCTTTCTACGTAGATCAAGCCTAAAGGAATGACAGCTGGAAAATAAAAATCGAACCCATTTTCAAAAAAATTACTCAATTGATTGTCTGCTGGAGTTAGTTGGTCGATTCTGAAAAATATTAAAGTGTTACTAAAAATTTTCCTTAGCAAAATAGCGCGGTTGCATCAAGAAAGGCGCGATCTGATTTTTATAAGCCCGCCCTTTAATGGAGGATCATCAATTTCTAGGAAAAATCGATATTTTACTAAAAGTGATCCAAGTAAATCAATAAATCGGAAGATTGATGTTCCGTGCTTTTTTGCAAAGATTTATCGAAAATGATTTCCATTAGAGCAAGCTTGCAATCGTTTTTTCACAAATATTCAAATTTCTTACGGTCTTGGATCAAAAAGTTGGCGGGGCACGCCGATAACTCTTGGAATTAGCTTAATGCCTTTGAACATGATCCATATACCGTATTTCTTCATCACCATCATTGATCCGCAAATCTGACGATTGACACGTGGATTGTAGGCGTGTGGGAACCGAATGTCGCGGCGGCCTGACGAGCCAAGTAGGTCAACGTGCGGGGACCAACTAAAAAATCCGGGTTATTGTGATTTCGTGGTGAGACCCGAAAATAGTAGAATTCCCTCGTACATCCTGTGCCTAAGCAGGTATTCAGTTCTTGATGGGTTGATGCGGTACCTGCATACACCTACCGTCTGCCTTTGTCACTGCCTGCGTCCCCGCCTGCGACTAAATGTGTGTATCAAAGGCCTACCTACAGTCTGTTTATCTGCCTCAACGTCTTCATACCTACTTGCCTACCTTGATTACATACGTGCCTACGCGACTACCAATTCGGCATACCGGTTGGCAATTAGAGAAGGCTAACGTAGGTAAGCTGGCAGGCCTGAAATTTGATTTTTGCGAACCGAATTACCTTTCGAAATGCGTGCGTTGAGATTCCTCCTTCGGCAGCCTGATCATTGGAGAAAATGTCATACTTCCAGGGACGTCATACACAGTACGATGCTTGGAAACTCTTCTTTATCGGCACTGAAACCCTTTAAAAGTGGAGGAGCCAACAACTAGACGGAGCCCTATGTAAGGAGTATTGTTTCCGGAAACATTTCAAATTTTAGGCTCCACCCACTCACCACGGAAAATTTCATTTTTGGCCGCCCAGGAACAAAAATAAATGTGCAGAAATAATGTATTTAAAATTGTAAGGAAAAACCATGAAATAGGGTGGAGCCTGCCTGCCTGCCGGGCTCCGCCCACTTCTGGCCAAACCATACCCCCTGTATACGTGGCATGACGAGTCGTCTTCCCACATTCAACATTCCAAGCATTCGTTGCAACAACTGAGAATCATCGGCAACGAATCCGACAAATATTCGATCATATCGATTTTGATGAGATTCAGGTGAAAGTTGTGCTTACATCGGTGATGTCACACACTTTGAGCTCCGGCCGAGCCAAGCGAGCTCGCTTCGGGTGTAGTTATCCATTGATCCATGTTTCCGGGTAGGTGACGAGACTCGTTCTCGTAGAGTTCGATCCCATGGTTCGCTATATACCAGTTTCACCTTAAAATTGTTGTCAGGCCACGCCCATTTTTAAAAAATGAATTAAAATTTTCTGTAGAAGAAAAAATTTCAAACTTTGGTGGGGCATTAAATTTTTTCACACAATTCGGCGGTAAATTCAATTAAAAAATTCTTTTTTTTTTGGCGGGAAATGTGCCGCAAAACAGAAAAACTGAAATTTCTAAAAAAAAAGTTGGTGGCCGAGTTTCCTCATTTTCGTGGTCAGAAAACTCGGCTACCGATTTCTTTTGCGTCGCGCCCTGTGATTACTTAAAAAAATCGGTGGCCGAGGATTTTTATTTTCGCGGCCACAATGAGTAATGAAGATTGCACAAAATTGAAAATAGGGAAAACGCGGCAGTCTAACATGTGCCACGTGGCCCGCCGTTAAAGAAGAGCCCTTGGTGGCCGAGTTTTATTATTTTTCTAGGCCACGTAACCAGAACTACACCCAATAAATGCCAGCAATCGTACTTAAATACCCTGAACCAGTTCCAATATGAAGAAACGAGTGTCCCTTACGCAAATCCAAATAAGCGAAGAATTTCGCTTAAATATCAATTGCTCCAACACGAAGAACTTGCTCACGGATAGAATGGACCGCCACCTCGGTTCGGCTGTGGAGGTCAACGACGGAGGACGTGTAAATTTCTGTTCACTAATCGGAAGAAAATCGGATCGATCGACAAGTCGAAAGGCTCGTTCGATGTTCGACGACGGATTGTGTCGTTTTTTACGAGAAAATCGATAAGATGTCGAGTTTTGGCTTTCACTATTGCCCATTTCTGGAAAATCGATTTTTTAAAATTTTAGATTTATTGATTGATTTTAAATAAATAATTAGATGTGAGCAGTCATGTATTTTTCCTTGTATATTTACGAGAGAGATCTCAAAAAATTATTCAAATAGGAAATTTTACGCCAATAAAATGTACAGTTGTGTGCGCCTTTAAAAAGTACTGTAATTTCAAACTTTCTGGCGCAATGAGTAGTTTTCTTTAAATTAAAAACAAAAAAAAAGCAAATCAAGATACATACAAAAGTTTAAAATTACAGTACTCTTTAAAGGATGCACAACATTTTGCATTTAAAATTTGTCATGTCGAGACCGTAATTTTAACGCAAAAAATGAATTTTCGCGTCTGTGTAAAAGAAGTGAGTTGAGGAGAAAAAACAATTGAAAAATCAACAAAAATTGAACTTTAAAAATCAAAAATCGTTGCGAGTTAATTTTTTAGCCTTGAATAAGCCTTAAACTAAAAAAAAAATAATCGACTCAACATCAATAATTTCGTTACAAGACCCAAATTAAAATTTTTTATTTTGGGATAATCTATTCCTAAAATTAATAAATTCCAGAGAAACGAGTAAATCGTGGCGAGACCTAGCATGTACCTTTAATATCGCCTCAAATTATTTTGGCCCGTACATCTCGAACACACGTGTTGCCTAGCTATCGAACAAAAAACGAAAAAAAAAACAGGTTTCTTTGAAATGAAGATAATCAGCGACACAGTGTGGCAAGATGTCTCAAATTATTGGAAAAAAAAAACGTGAAATTCTCAGAAAACGGACCGTTCTGTGGCAATGGAATTGTGAACGGCGTGCAAGGCCACGACCTGTGAAGAGGGCGTGAGAGTGTAGAAAAAAAGGAGGCGAGAGAAAACGGCTGACCCGTGGATAGACTTATTCAGGAGACGCAGAGCGACCGTGAGAGACCTAAGCAGGAATATTTGAAAAGGCGTGCAATAGTGTTGGAAATTCCCATAATAAATGGGTACGGTAGGTATGACCTTACGGGATATTTGTGGGTCTCGCCGCGACGAGTTTTCAAGGTGCATAAGCAGTTTTTGCGATGGGTCTCGTCACACACGGGATTATAGATTAAAATTGTTGATTCGAGATAAATGGAAATTCGAAGACGTCTAAAACAGTTAGAACTTTATTTTAGTTTACATTGAGCTCAACTGTCCAACCCCTTCAAACTTTTTCCACTTTTTTCTTGATTTACTTTTACAATGCCTTTATGCTTTTCGGCCGTTTTCCTGGGGGTTACGACCACGAAATAGAATCCTAACTTGGTAAAGCCTAAGCAAGACTAAACCTTGGTCTTTCAATTATACATACACATCCTTTTTAAACGATATTAATTAATTTACAAAATACCAAAAAAATATACAAAAAATGATTTGAATATATGCGTTTCCCGCTAAATACCTACCCCCAACTTTTGGTCCCGTGGAGCGCGCTTGCACTTAAACTTCAATTGTTCACATCCCCATCTTGTTTTAAATTGTTTTTCCCTTTATTATTATTATCCTTATCACGAGATGCCCTTGCAAAACACATTGTAAAAACAGTATTCTACCTCAACTGATAGATTAATAAGATTTTGTGTACCCCACAGTCCTTCAGGACCATAAAAATATTGATAATTGCTGATAAGCTCTCTCAGTGGTCTGTAGTTTTGGTGATATTTTGGGCAACAAATTTAGATTATGGAAACACGGAAATTCTGACAATGCGTTTTGCGCAACATATTTGACGCGCAAAATATCTCGTGGCGAAAACTACATACGGTAATTCATGACTACTGAATCGCTTGTCATTGTTTTACGGGCTTGATGTTGGAAATTAATTTATTTTCGAATTGTGACAGCAACCGATATTCAGTTTTCCTTTGATTTTTTGTTCCGTATTATTTTGTTATTTTTATGTGTTCTTTCTTTTAATATTTTATCAATTAATGAATGATTTCCGTAAATCGACACAAGCACTACAGTAGTCATTTAAACAATTACTGTAGTCGCTTCGAGATATTTTGCGCGTCTATGTTGTGTAATTCGTAAAGAAAGTTTGAAATAATAGTTTTTAATTAATTTCTTATTCATTCACTGTCAATTCTCACCGAAAAAAAAAATCCAAGTTCGCCGACTTGCGGCACGATGCCTCTCCAAAAGGTTCTCAGGCCCATTCATGTCATTCAATCCATCCAAATGAACGACTTTTCGTTCAGGGCCGCCCTTCTTCTTTTTCCGGTTTAGTACTTTTTCAAACCGAATAAAAAAATCCGAAATTGACTGCAAGTGTGCTCTATTTGAACTTAGACTTCACGCTATTTCGGAATTTTTTCCGATTTTCTCAAAATCTTTAACACTTTTCTAAATGCATTGTTGCATTAGTGACATTTTCCTAGAAATTCTACTGCAAACGCGCGCATCAGTTGCGAAAGTTTTTGGGTCTCACAACGATTTCGGAAGAAAAACGTTTTATCCGAGACCCGGAACACCATGCCCGGATGGAGCGCGTTTGGAATTTTTTTGGTTAAAAATTTTGCGCAACGACAAAATAACCGCGAATTTTATCGTATTGTTAAATTATGACTTTTCCCGGTCCCAGAACGAATTAAAGCAATTATTATGAAAAATCAAGACCACAAAAAAAAGCGCAATAGAGCGCGTGTGCACCTTTTTTTCTTTGAAAAGTCTCGTTTTTTTCTCGGTAAATTCACTGTGACATAGACCTTTCTCGGAAAACGAAAAGTGTAGTAATGGAAAGTGAACAAAAGTGACAATAATCTGAATTGCGTTGTTGTATTTATCTTCTTTTCTTTTTAATCTGCGAAACATAAGTTTTGGAGAGAAAGTGATTTTCGACGAAATTTTCCTGATTTTGCTAAAATTGTACAAAAATCATCATTTTCTGTGGGGTTTCTCATTTCTTATCCCAAAATTTATGCGCCTTTAAATTTGGGGGATTACTGTAATGTTTGTATTTTTCAACTGTGTTTCGGGAACACAAAATTCTGAGAATGAGTACTGCACAATATATTTGACGCAATATCTCGTAGCGAAAACTACAATGGATTAAAATTTAATGAAATATCGTTATGACTATTCGAAAAAAATTTCATTATGGAGCCCGTAAATCGACACAAACTCTATGTCCTGTAGTCATTTAAAGAATTACTGTAGTTTTCGTTACGAGATATTGTGCGCGTTGTCCCCGTAATAGTTTAACTTTTACCACGTGGTCGCCAGAAGGCAAGAACTTCTGCTACCGGATTTCATTTCCTCTGCCACAAACCCTTTGGACCCCCAGTAGAAAAAGTACATAAAAACAATTCCGGGGACTGGGTCTCCAATCTCTCGCCCCCACTCACTAACAAGGGGGACACCCTCAGAAACGAATGCCGTCTAAACGTCTGCACCCTCTCTCTCGTCGCTCCAAATTCTTGGATCAATGCGAACTAACACGCAGTGACCCCCCTCCACCTTCATCCACCCAAATGTTTCATCAGTTCCCGGCCACCGCAGGCTTCTCTCTCTTTCTCTAAAGCTCTCATATAACTACTGTCTCTCTCTCTCTGCTTCTTTTGCTCAATTGTTCTTCTTCATCACTACTATTTGCTCAATTTTCGTAAAATGATATTTTATTTTAAAATATTCATTTTTCCTCCCCCCGCCTCTGCTTTTCATCGCTTGACGCGCCACATACACTACAAAAACCGGTTTTTTCTATCTCTTCCGCCCGATCATAGAATAGATAGTGTGTGCTGTCAAATTTCCATTTCCTGGAAAAATCGCGCCGAAATTCCAGAAAATTCCACTTTTTCTAGAATTTTCAGGTCGTGCAGTTTTTTCGGTTTTTGAATCTAATACAAGGCGAATTCCGTGAAAATTAATTTTTCCTCATTTGACGAATAAAAAATATTAGTATTGTTTTTCTTTCAAGAACGTGTGATTTTTTCACAATCTTCTATGGTTTTTACGTGGATCTTGAACTTCCACAACTTGACAAGTCTTTGAAAATTAATAAAATTTCACCGTATCTGCCGATCGTTGCAAGACACACTCCACATAAGAAGTCGTGCGCCTTTAAACTGTGTACGGTAACTATAGGAAACTGATTTAATCCACTTTTTTCTTCGAGCGCTTTATCCGTCTATTTTTCCAATTTTTCCTCACTCTGATTTCGAACGATTTTTTGCATCTTACCTCAAAAAAATTAATTAAATGCATAAAGTGGAATTGCTGATTCTTTACCAAAAAAACACTTAAAAAATCTTCTCATCAATTTCAGTTCTTTCTGGCATGGCTCATTGTTTATCGACACCTGCTTGTTTTGCTCCGTAACTCCGCTCCCAAATTTTATGAGTTTTTCTTCGAAATTTCTCCATTTTTCCCGTGGTTCAAAAACCGCCAAAATTCGCTTTTTCCAGAATTCGCCTACTAGCACTACTAGATGTGTTAATTTGGGGCGGAATTATTTTACAAAAAGCAATGTATCCGGTTGTACGGGCTTACTGAAAATGAGAAGCTCAAAGACCTTGAAGGAGCTGTGCATATGGTCAATATATCCGATGAGGATGCCATTCAATTTTTAAAAGGTGGATAATTAAGCTGAAAAGTGGAAAAAAAAATGCATTTTTTACTTCAAATTGACCTAAAAATTGGACTAAAACGTCATAAAATTACTGAAAAGTCAGAAAATTGTCTAAACTTAATTTTCGCTAAATAATTCCAGAAAAGCCGACTGGGACATTGCAATGTCATCGCGAAGAGTGTTTCCGAAACAAATGAGGATAAAACAAAGTGTAGGTTCCGGGCACTTCGAGAGGTAAATTTTTGAAAAATTTCAGAATCAAACTGAAAAATAGATATATTGTGTGAAAAAATGCTACCATTTTCTCCGTAAAAAGGGAATTTTGACCGGTTTTTCAAATTTTAAACTGAAAAAAAAAATTATATCTGAAATTTTGCTCTTTTCGGCGCGTTTTTTCTCAAAATTTGATGAAAAAGTTCTAGAAAACAAAAAAGCCTTTATCAAATGTACTTGTTTCTGCGATTTCTCAAATTTAAAATTTTACGCGTCAAATCTGGTGTTTTGACTCCGCCCACTAAATTTAAACCTTTCGTGAAAAAACAATGTTTTTCTCCGATTTTTAATAATTTAGGCAAAAAATATACAAAATTTGCCTAATTCACCTATTTATTCCAAAAAAATATCACAAACTTCCTGCGCGTAAAATCGGGTGTTTATGCTCCGCCCACAAAAATTTCTTAGAATTCGAGTTTCGGCGGATTTTTTCTCAAAATTTCATGAAAATTGTGAGAAAAACTACAAAAAGTCTTTGAGCTTTACTCTTTCTCTGCGATATCTAAATTTGAAGATTTGCGCGTCGAATCTGGTGCCTTGGCTCCGCCCACAAAATTTGAATCGTTTAAAAAAATGTTTTCACCACTTTCCCCGCTTTTTCGCCTGACTACCAATCCCAATTTTTTTGCAAATCGATTTGGATTGATTATCGTGTCGTCTACGTGTTCTTAGCCTTCTATCTTCTAGATTTTGGAGGTTTCCCTGATGAATGTCGAACGTTAGAAAGATTTGATAGAGACGCAGACACAGAAGAGCCTTGAGTCGCGCGTCCAGTAAGTTGTTTTCTGGAAAAATTGTAAAAAAAATTGAATAAAAAAAATGATATTTTTAATCGAAAAAAAAAGTTTTCAAAAATCAAATTGGAAAAGGTGAAAAAAATTCAACAATAAAAAAAGAGCGACAAATGAATAAAAAAAAACTTTTTTTTTTTCCAAAAAAAAGAAAATGACCAAATGTTATTTAATCGCCCGAAAAAATAAAAAACGAAAAATGAAAAAGGAAATTTTGTTTTTACAATTAGAAAAAAAAAATTAAAAATGTATTAAAAATTTTTTTTTGACATTTTCTTTCGCTTTTTAATAAGTTTTGACTAGCGGGGCCTGCGGGCCCGCCAGTTGGGGTGTAGATCGGGCGAGTCCCCCAGTCGGGCGTATGTTCTCGTCTTCGCCTAGAACGTCAGAGGATTCGCGACAATTGCAGTGAGTCAATGGGAGGGAGACCCACTCATATTTTATAAAATCGAACATTTGTATTTGAATCCCGAGCACTCAAAAAAAAACGAAAAAGGTGTTTTGTCTGTTGGGGGAATCGAGCGAAAGAGCAAATTATTCACAGCTATACGCACTAACCAGCCATGCGGGAGAGACCTCTCACAGAGATGTAGGGAAGGAAAATTTCTGGGGGGAGCGCGGGGGGGGGGAGTTGTCTTTCGCTTCCGTTTTATTCAATAATGACAATTTGGGGGAAGCCGTTTGAAATAACCGTTTATCACTGATAAGTCAGCAGTAAACCAATTTTTTGAAAGTTTTTTATAGCATGATTGTACTTATTATTTAATTCCCGAAAGAGAGCCGAAAAGTTGAAGGTGTTATCTTGTAAATTGTTTTATTTGAAGAAGAAACCAGTTTTGGCTGAAAATTTTGAAAAAATAATATTGGCAGATCGAGCATTGCGTAATGCGACGAAACTCCAGCTTCCAATTGATAAAATCAAAAACTATGAATCTGAAATACATTGCGCAAAACGACTTTAGTGGACAAAATTTTCAGCAGATAACCGAGGAAACCACTCCCCCCAGTACTAAATTGAATTATTGTTTCTTGAAATATTTTCCCACGGAACTTTTTAAATTTTATATGCTCTCGATGCGTCTTGATGAGACCTACACATCAATTTTTGGAAAACTAAAAAACTTAAAAACTAACCGCTTAGTTATGAGTGAAAAAGTAGATTAGCAATGGGAAAGTGTGCAAAATTTGGCACTTATTCGTCTTGCTCGGCGGACTCATATTACTTTTTCCAATTCTGCGTTAACAATCGTGTTCCGTACTTTTGTACGTGGGATAAAGATAAAATATAAAAGATGCAGTAGAACTTGAGACAAAGAGGAAAAACTACTTTTTCGGAAAAAATTTTTTGTTGGCAAAATGGCATTTTTTGGCCTTTAGGTGTTTTAACACAACTTTTTAGCCTTTTGCCACTTATGAACTCAAATTTTCTTCTCACTCGCTCAAATATCCACCTCCCTGATTGTAGTATCTTGCACATAAATTTAACAAACCCGAGCAAAACCCGAATTTTTCAATTAAAACATGGTTTTTTGGGGGTAAAAAAAGCAACATAAAATTTTTTCAAACGGGGGAAAGCCGCCCTGAGCTCAGCTTTGCTCCAAACTTTGTGCAGTTTTGCTCCGCCGTGGGGTGAAATATTACTAGTAAGCTGTCTAATATTACAATATTCAGTCAAACCGCTCTGCGAGTTATTAATGAAAACGCAGTGTGACTTTTCGCAAGCCTAAAAAAAAAACGCGAAAAAACGCGAAAAAGGGGCGGAGTCTGTACACTCGGCATTTAGTAGAGACTGCTGGCAGATTTTGAAATATCGGAAATACTTTAAAAGTTCGTTTTTTTCCACGACACCTAAACTGGTGGCATCATGTTGATTCGGCCAAAAACCCGCTATCAACTACTGGAGAAGGAAATTGCCTTCCTCACGTCGCATCGTTAGGTAAAAGGTTTTTCAGAGGCGAAAAATCCGAAAATCGCTAACTTACTATTTCCACTGAAAAAATTGTACGCCCTTCATAATTTCACTATTTTCTGAATTGAAAAAGACGACAAAACTATTTCAAAGCTAAAATTGCCCCGAAAATTGTTTTTTTACTAAATTTATTTTGCTCGGCGAAGTGCAAAAATAAATTATTGAATTAAATCTTTACATGTAATCTTCAACAAAATTTAATCGTAAATTTTCAGGTATGTGGGGAGTACGATCGTCCTATCACTTCGTGAAACTCTGTACCTACGAACTTCTTACATGGCGCCAGAAAAGAAGCAACGACTGCGGGAATCGGTTGACAATCATATGAATCAGGTCAATTGGCGGGAGAACAACCTGTGAAAAATTTCTTAAAATTCGGAAAATGATCAAAAATGAGCTGAAGACCGGTCACGTAGTTGAAATCCGCGGAAAATTCCCAGAGGAAACAAGTTTCGGTCAAGTTCGCTTGAATTTTTCTCAAAAAGCTCGAGTAAAAACACGGAGTTGAAATCCGCAGAATTCGAAATTCCCACAGGAAGCAATTTTCGTGGATTTCAACTTCGCGAATTTTGCTCAAAATGCTTCAGTAAAAACTCACGGAGACATGTGAAATCCGCGGAATTCGAAATTCCCAGAGAAATCCTAATTGTAGATTTCAACTTCGCGAGTTTGTGTTCCCAAAAAGCTTGAGAAAAAACTCACGGGGTTGAAATTCGCGGAATTCGAAATTCCCAGAGAACACAATTTTCATCGTAGATTTCAACTTTTCTAGATTTTTAGCCAATTTTTTATTACATTATGTTACAAAAAAGCTGTAAATACTCACGGATGAAATCCGCGGAAGTCGATTTGATGTTGTAGATTTAATCTTTTCCAGAATTTTCCAACAAAATACGTTAACCGGAAAGAATTATTGCCGACACTCCAGGAATCTAGTTTTCAGGAGATGGCTTTCAACGTCGAGAACTTCGCACATTTTTTTGCATTTTTAAAAAATTTCACCAATTTTCCAATCAAAATTTTTTAAATTTCCAGAGTAACGGTCTCGCATTGACCCGTCTCTCGGAAAATGAAGAGTAAAAACTCACGGAGTTGAAATCCGCGGAATTGTATTTGAAATTCCCAGAAGCACAACCATTCTCGTAGATTTCAACTTCGCGGAGTTTTCGGTCAATTTTTTGAGATTTTTTCTCAAAAAGCTTGAGCAAATACTCTCGTAGTTGAAATTATTCCGCGGAATATTCCAGGAAATTCGATTTTCGTAAATTTCTTCTTTCCCAGAATTTTCCAATTAAAAAAGAACGGAAAAAATTGTCCGACATATCCTCCATGGACTTTAGCTTTAGATTTCAACATCGAGAACTTTTCTCGTAGATTTTTTTGCATTTTTTAAAAATTTCACCAATGTTTCAATTAAAATTTTTTTAAAAAATTTTCAGCGTAACGGTCTCGCATTGACCCTGTCGCGGAAAATGAATGGGGACTCGAATCGGATCGATGTTGTACTCGGATAAAATATCATCTCAGTACCCCGTAAACAAGAGGATAATGGCTGGATTCAAATTCCACAGAATCTACGAGAGTCTTGAGGCAATCCACGAGAGGTGTTCGCGTTGGCTCATCTGCTCTAAAGACCAGTTGTGGTTGTATCGGACACGGTAGGGAATTTTCCATTAAAATTTTTTCTTCAAAAATTCATTGAAGAGAAGCAGTAACAAAGAATTTGGTTAATTGTGAATTTTACAGAAATATAGAAAATTTTAATTTAAAAAATTTCGAGATTGGTGAGCAAGGGTGTCAAGTCCACCCGTGTCCCGTTTGTCCCGTGGTCCCGTTTTTTGAGTGTTTTTACGGAACTGGACGTCTTTGGTCCCGCTAATTTTTGAGCGTTTTCACGGGAACGGGATGTCCCGTTGTCGCGTTTTTTGTTTTCGCGGGAACGGACGTCCCCCCGTTGTCACGCTTTTAAAATCTGGTTTTGTATCACGGGAACGGGACATCCCGTTGTCCCGTCTTTTGTCTTACGGTAATATTGACACCCTTGGTGAGAATAAATCAATAATACACATAATTTTTGGAAGAAAAAACGATTTTAAAAATGAAGCTTAACATTTTTTTTCGAAAGAAAAAAAGTGTAAGAAGTTTAGCAAAAAAAAAATGAAAAAAATATCTTCAAAAATGTTCAATATTGTTTTAAGGTGCAACTATTACAAGAGCACACAATTCTTAGAATACGTAATGCGCTACCTATTTGACGCGCGAAAGCTACAGTAATACTTTTATTGTTTACTGTAGTGACTAGCTTGTGTCTAGATTTACGACTGGAGCTTGTGCAGATTGATAGAATATTCAAAGGGATAATTTATTTATCGATTTAATATTCAAATTAGGCAAAAAATGAGAAAAAATATACATGTGAAAAAATTATTTAAAAAGAGAGCTCGTAAGGCATCGACACACTAGTACATTTAAAGGTTTACTGTAGTTTTCGCTGCGAGATATTTTGCGCGTCCAATTTGTTGCTTAATACGCTTTCTTAGAATTTTCACATAAGACGGGTTTTCTAGGAAAAATTTTAATTCTTCATAAAATTCGTCAATAATAACTAAACCGTTAATCAAAAAAAAGTTTTTAGGGTGTCATCAGAAAAAGTCTCAAAAAAAGGCGGTCATCAAAAATCCATCAAAAAAAGAAAATTGAAAAATTTGAATTGAAACTTTTTCGAATTTTTGAAAAAAAAAGTGTTTGAATATTAAACGTAATTAAAAAAAAAGATTTTCCTTTTTTAGAAAATTCTATTCATATTAGAACAGTCGATTTTATAAAAGTATCGATTTTTTTCAGAATTAATTGGATTTTTTGTAAAATAATAATCGATATTGAAAATAAAGACCTTTCGCCTTAAAATATTGTATTTGACAGAAAAAATGGTGTAAAAAATTTTTACCAAAAACCCTAAATAAAATTGCAAATAATTTTCACCTACAAATTAATTGTTTATTAAATAAAGTTTAAATAAATTGCAAGAACAGGAGTACGTGTTTTCAAAATTATTCTTTAAAAACGCGGGTTCTTTTAATTCAGAAAATTCTTTTACAAAAACTCAATAATTACGGATTTGTCAAAAATTCGGATAATTTACCAGGAAATTCAGAAGATTTGGATAACATAATTCTAGTTCACTTCCAAAAAAATGATATGCGACTTACTTAAGGTACAACTAACATTAATTTTCCAACACTTATGCTGCTTAAAGACACGCCAATGGGGTCAAAATGACCGAATATTATGTTTAAACAAAAAAAATTTTCTGATTTTATATATGATTTGAAAATTGGAAAAGTAACAGTTTTAACCTAATTATTTTGAAGTTCTGCCAATTGGATTTGTTCGGTGCAGCGCGCTTGCAATAGTTTCATTTATTTATTTATTTATTTATTCTCGTTATTTCACGGAGGATTTTGCACTTCCATTTTCGATGTTTTTTTTTCTCCGAACGAATGAAAGAAATAAACAAGACAAATGTGAAATGGTTGTTAAAAAGTAATTGAAAATGCTTATAAAACTGTGATATTCTTAGTTCGACGAAAAGACTGAGATGAGGATATTTCTCAGTGTCACTCATTTTCAATTACTTTTAAACAAACGTCATATCGCATTTATCTTTTATTTCTTCTCCCGATTTTCTGAAGAAAAAACATAGAAAATGGCAAGAAAATCAGTGAAAAAACGAGAAAAATATATATAATTCATTAAATAAAAATAATGCAAGCGCGCCCCTCCACCGAACAAATCTAATTGGCAGAAATTCAAAAATAATTAGGTGAAAACTGTGATTTTTCCAATTTTCAAAACGTAAAATAATATAAAACCTAGAAAATTATTTTGAATTTTTTTATCATAATTTCCGGTTATTCCCATGGGCGTGCGTTTTTAAAACAATTCCCACTGAGCGTAGACCTATGTTCTCAAAAAATGAAAACGAGTAATACTAATTATTTTTTAAAAATCCAATAGTGTTTAAATTTTTTTTTTGCAGATTCTGCGAAACGCGGGGAAAGGCGAAGATGACTGTCTCCAGTGGCTTTTGGTGGAAAATATATTCCATAAGAATGCCCACCATCACAATGTCATCGATGACGACTTGTTTTATGCTATGATTCTGCTCATTTCTCACCGGACTATTGTACCATGAAAACAGAGACTAACAATAAACTTAAGGAGTTTTTTTATATGAGCAAAAATATTTTCAAAATCTTTTAACTGAATTTTCAAATTTCCCCCTAGCCACCGGCCCCCCCGTTTTTTTCGAAAAGTGAATTGGAATTTTCGAAAGTTGCACAAATTTTTCTTTGAAAATTCAAATGTTGGTCAATTATTTATTCGAAAAATCGACATTTTTCCAACTTGTAATCTTTTTATTCTAAAAATCCCAATTTGATTTGGTAAAATTTCTGTCAACAATCAATTAAAAATCCAACATTTTCAAAAAAATTGTGAATGTATTCGGGAAATTCGAAATTTCCTATTTATTGGATAAATAGGCTAAAAGTTTTCGATTTTATAATTTTTAGGAAAAGAAGTTGTCAAATTTTTTTTTATAAAGTTTTTTTTTGAAATTTCACTAAATGAGCCAAATTTTAACAGTGGAGCACCGAAATTTGCGACTTTGCTTTTTTAGACTCAGGATCCAAAACTAACGAATTTTGTAATGATACATCTGACAATTTCTCAAAAAAAAGTTATGGCTGTTTAAAGTTCGGGCAAAATAAGGCCCATTTTCAGCTAAAATCAAAATTTTTTCCAACTTCTAGGTGTCGCAACGTCTGATGGACCCTAATTTTTATCTATTCATCACTTTAATAAATATTGTGGCCTTTGATTGAGCATTTAATCGTTGTTTTAAGTTCATTTATGATCTTTGGAGTACAAATAAACGTTACATTTTGTACCACCAAGACCATAAATGTATTTAAATCAACGATTAAACGCATCATCAAAGACCACAATTTATTAAGTAGAATAAATTAATGCGAAATGTTCCACACGTCTTGCGGCACCTAGCCAAGTTAAATTTTGATTTATTTTAGCTGAAAATGGGCCTTATTTTTCGCCGAACATTGCCATAACTTTTTTTTGAAAAATTTTCAGAACGTTTCATTACGATATTAGGTAGTTTTGGGCCACTTGGGTCTAAAACAGCAAAGTCTCAAATTTCGGTACTCGACCTTTAAAGAATTCATATAATTTTCTAAAACAACATATATTTACACAAATACTTAATTTAGTATCAATATGAATTATTTGAAAAATCAAAAAATTTATATGTATTTTCAGAAAAAATTCCCATGATCGATGTGAACCGTAACCTGCTGCTCCTGTCCATTCTATTTACAGTTGATCCAGGAGAGTCAATTGGTCCAAATAGAAACAAATAGTAATACACAGACAACTACAGATATGTCACAAATATGGGTGATAAGCTTGCGTTGATGTAAGTCATATGGATATTGTTAGGTAAGAAAATGAGAAAAAGGATTTTTTCAATTTTTTTTTCTAAATAAAACATTCAATATATCGTTAACAAGCCAAAAATGTGTACATGTTTTAGTTTAAAAAATATTAAAATTTTTTAGTCCCAAAATTAAAATATCGAAATCAAAGTGTTTCCGACATTTATATAGACGAATTCTATTTTTTTAAAATCGAAATCATATTTTTAATGAAAGTACAGAAAACAGCGCCAAAAAAGAAAAAAACGTTTTTTTTTTTCGAATCTTTCATTACAAATATTTGAAAAAACGAAAACTACAATTATGGGAATTTCGCGAAAATTTTTTAAAAAAACTTTAAAAAATTCTTAAAAACAGCTATATAATCACGAATGAGAAATATATCGGAAATCCGGAAAAAATTAAAAAAATTTTGTGCGTATTTGTCTGAAGTTATTTTACAAACACCAAAAATAAATCAATTATTGTTGGAAAAAATTGAAATACAACGGAAAACGAATTATTTATATTTAAAACGAACTAAAAAAAATCCCGCATCACAAAATTATTGGAAAACGAGAAAGCTGATTTTTCGCTAAAGTTCAAAAAAATTTACAAAAAAAGAAAAAAGTATTAGAAATCGGTAATTTTCCGAAAACTGAAAAATTCGAGTTTTCTAAAATAAATTAAAAAAAAAAATCAAATTCCACACTTTTGGAAAATTACGGAAAAAAAGATGTAGTTTTCTTTAGCTTTCAGCCAAAATTTTACATAAAAATTTCCGCAATGCATAGTTTTAGAGAATAATTTTAAATTGAAACACTAAATTTTTTAAAAAACTTGCGTTTTTTTTGAAAATCCCCGAATTAAAAAAAAATAAAATTTGAATTTCAAATAAATATTTTGCTAGCAAAAATAGTTTCTAAAACAAAAATTTGAAAAAAAAAATATTTAATATTTATTTCATATCCTTTGATTAAAAAAAATCTAAAGAAACATTTCAGACTAGACGTCGTCGTGGCTCAATACGCAGCTCGCGGAGAGTTCGAACGTGCTCACGCGCAACTTCTCACCGAATCTCGTGGTGAAAATGGGCAAAATTTGCCCAAAAATTAATGAAACCAAGAGAAAGTGCACATTGTTCTAGTGATGAACAACTATCAAATAATGCAAAAGGAATCACATTAGCATCAAGTGGCATTGGTTCTGGAAGACATGAGAAATGGAGATTAAGCAATAATTAGGGAAGCATTGTTTTTTTTTTTGGCCTAAAAATTTTAATAAAAAATCTGCTTGAACAGAATTTTTGAATCTTGGAAATAATTAAAAAAAAATGTAGTAATCAATTTTAATTTTAAAAATTAGAAACTTTTCAGATAAAACATTTTTATTTTTTCAAAAATCAGAGTTTGAATCATTTTCAGAATAATCATAACGTAATGAAATCAAAAAATTCAAACTACAATACTACGGTAACAAAAAAAATCAGAATGCGTACTACGCAACATATTTGACGCGCAAAATATCTCGTAGCGAAAACTACAGTAATCCTTTAAATGCAATACTACTGTGTCGATTTACGGGCCTTGATTCTATTTTTTAATTAATTCATTTTCGAATAGTGACAGCCATATTACATTTTTATTCTCTTCTTTTTTGTATTATTTTCCCTTTTCTTTTGCCTAATTTGAACAGTCTATCAATCGAGCCCGTAAATCGACACAAGCGCCACTATAGTAGTCAATTTTAATGGCAGAAGTACTGTTGTTTTCGCTACCAGATATTTTGCGCGTCAAGTATGTTGCGTAGTACGCATTCTCAAAATTTTGTGTTCCAGTTATTTGGTAGTTTGTGAATTTTTTTAATTTTCATTAATGATTATTCTGAAAATGAAACTCTAAGTTTCTGAATAAAAATGTTAAAAAATTTATTTTAAAAGTTCCTCATTTATTTAAATTAAAATGGATTCTTTTAATTTCCAAAATTTGTTTACAAAAAATTCGTTTAAAATCGAAAAATTGAACTGTTAAATTTAAACTTTTCAAAAAAAAAGTTCAAAATTTTTCTAAAGTAAATTTTCAAAATGATACATGTAATTTAGATTATAATTTAAAAAGACAACCAAGACAAACATTTTTTAAAATATTAAAATTTTGTAAAATATACAAATGAATGTTTATCCGTTAAACGACTAAGCCTTAAAAAGCCTCAGTCTAAGCCCAAGTTTCCAATGCCCCTAAGCCTAAGGTCGAACTGCAGTTTTTAAAAAAAAAGTCCCAAATCCGCTTTCCTAATATTGGTACCAAACCTCTTATTTGCCAAAATGAAGAAAATGTTTTTAATTTGAAATTTGTTGATCTGAAAAAAATGTGAATTAATTGCCTTTGTCGGCTGGATTTTTTTTTTGGAATCTATTTTAAGAATAAAAATTGATTATCTTGCGTTTTAAACTTTGATTAGGGTATTTTAAATTCGATGGACGGCGAGTTTTGGTTCAAAAAAATTAAAAATCTCGCCGTCCATCGATTTTTAAATACCCCAATCAAGTTTAAAACGCAAGTACTTAACTTGCATACTCGAAAGTTGACGATGTTCAAAAAAAAATCGTTTCCAGCCCTTCGACATCGATAAGTTGGTCAAATTTCCGATTTCTTATTTTAGGCCATTGTTTGAGCCGTCATAACTTTAGTTTCCGTGATTTCAAGAACGCGTTTCATTATTAAATTCGGTGTTCTCGGACAATTTTGAGTCTACGAAGCGAATAAAACGACTTCACCACCTTTAAAGCTCAAAATAAACGTGCACAAATTTAATTTCCTATACAGAACCCACGGGCTTCGAACTTTTCGTAATTCCTCATCAACACGTGGCAAAGAAAAACTAATCGATACGGACGATCGTATTGCAAGAATGAATTCGACGTGCGTTCTTCGCATCGGAATTATTGCCAACTCATCACCAATACATGGACAAAATGAATCATACTTCGAACGAAACAACGTGCATAATTCCAACAGAATCAACGAACACAATCGGATAGTCGGAAACGGATTAGTCGAAGTGTCTGCAGTGCAAGCTCACTAATGCTCGTGTATCGGTTGTGATTCGGTACGGGACCTACTTTTTGATGTGAATTTCGAGAAAAAAATTGTCAAAAAAAACGGAGAGAATTTGGCACAAGTAGCCTCAATATTTGAAAGAAAAAACCGAACAAATTGATGAGGGGAAGCCAAAATACCAGAATTTACACCCAATCTAAAGTTTTATTGATTTTTTACAAAAATTTGCTCAGTTTTTCAGTAAATTTGCCAGATCTGACCATTTTACTATTAGGAACCGTCATAATTCTGGGTTTTGCCAGACAACTTCCTGAAAATTTAGAACTAATTAATTTTTAATTTTTTGTGGGGGGATCATGTTATTTCCTAACAGAATACTTTGATTTGAATTTCGAAAAAAACCGATTCTAAGCTTAAACATTGACAAAAATAGCAATGAATGTCAAAGAAATTGCTAATACATAAAAATTGTGAAAAAATACACAAATAACAATTTTTATTTAAACTCGTCATTAAAAATTTTTTCAAATTTTAAAAAATTGAAAAAATAAAAAATTTCTAAATTAAAATTACTGTAAAACATTTTTTGTTAAAATTTGAAAAAAATTCTAGAAAAAAAAAATTTGCATTAAATTTCGTTTCTTCAAGCCGGCATCTCAAGTTACAAATATCAAGTGTGATCAAAGTTTTGCTTGGCACAAAATGAGTGTTCTCACGTCGAATTGCGACCAATTTATGGGAAATGCTGGGCCACCGTGCAAAATTTCAACACTCCCGTCATTTGGTAGTAATGATAGTAATCAGAATGATAAGGAAAATATTGTGGAGGTACTTAACGTGGTGCCTAAAGATGGAGCCAAGACACTTACCAGGTATGGGGATTTGAAATTTTGAAAAAATTAGAAGTTTCAATGAAGACAGAAAATATTTTAAAAATTTATTTTTAATTGAAAAATAAAACTCCCAAAAAACAGTTTTCCCAAAAAAAGTGTTTATGTTATTTGTTTATAATATTTACGGAATTGATTTTAAAAATTACGAGAACACAAAATTTGGAGAATGTGTATTGGTCGCTACATATTTGACGTGCAAAATGTCTCGTAGCGACAAACTACAGAAATCCTTTAAATGGCTACGCGCACTAGTGTCGATTTACGGGCTCTATTAACGAAATGAATTAAAATGATTTAGTTATCGAACAAAAATCATTTCATTAAATCGAAAATCAAGCTCGTACATCGACAAACAAGCTACAGGAATAGTCCTTTAAAGGATTACTGAAGTTGTCGATCCGAGATATTTGCGTAAAATATGTTGCGCAATAGCATTCTTTGAATTTTGGCTTCTCGTAATATACGAAGGATGAAAATTTCAGATTTTTAACAAAAAACTTGTGAAAATAAAATTTATGAAAAGTATAAAAAGTTGAAACAGAAATTTTTTTGAGAAATATCGATGTCAATTTCTTCACAAAATTTTTCAAAAATCGATTTTTCTTTCGAAAATTTTTTTTTGTAATTTTAAATCAAAATTTGGCGATTTTCAAAATGTTTATTTTATATTTAATTTCTAAAATTAATTATTTTTATTAAAAAATATATAAACTCAATTTTAAGATTGTAAAATGAATTTGGTATGCCGTTGAAAAATAGAAAACTTAAAATCTTTTTAATAACTGACACAACTGAAAATGTTGTTTGAAAAATTACATTTTTGCAAATCGAACATTTTTGACGCGCAAATTTGTAAAAAAAAATTTTCCGATTAACAGAATAGGGAAAACTGTAAAATAGGAAAAAAATTTACCTAAAAAGCGTATGTGCCTTTAAAATGTGCAGTAACCCAAAAAAATCGATTTTTTGCAGTATGCGAGCTGTGGAGGAAAGCGAAAACGGTGTGGAGGAATTCGTCCACTATTATATGGACGATGAAGTAGCGGATTCATGATTCTATTATACCCATCTTCGATTTTTTTGAAAATATCTTTACTAGAGACCAGTTTTCATTTGAATTTTTATCGATTTTTTTTGGATTCCAAATTTTTGTTCTTTTTTTGGGACCTTGCTTGTGTGTTTTTTGCCGGCTGTCCTTCTGTCCTGCCAGCCAACGGTGACCTTTTCTCTTCTTTTTTCTGTCTGAAGAACTCAATTTTCCCGCCTTTGCTTTCTTCGAGATTTTTGCTTCCATTTTTCATATCCGCGCCAGCTTTTTCTCTCCCCTCCAGTTTTTTTACCCATATTTTCGAGCTTTTTTCTGTGATTTTCACCCCCAGAAATTTTTTGTACCAAAAAATTGATGCTTTTTTTTTTTCTCGTTATTTCCAGCAAAATGCTTGGGCAAAGAAATAAACTCTTTTCTAATTTATCATTCAAAATTTGAGACCAAATTGAAATCCCACGCAACTGCAAAGTGGCATTTGACAATGCACAGCATGGCACGCCTTTTCGTCTCACCCGGGGGAACGCGTATTCTGGGACCAGAATGAGGAGGCGGTGGTGATCGGAGAAAATGAAGTATGGACCACATCTGGAAGAGACACCTGATTTTACGCGCAAAAATTTTGAAATGTATCGATATTTTCGGTCAAAAATCAATATTTAGCGATTATGGGCACATGGGCTTCTGGCCTTCCTCATTGAATATTCGCGCTCCATTTACTACCAACTGCCTGCGGACACTGACGCGTGGAAAAGTGTGGTGTACCTCCACACGGGGGCCACAAACATCAGTTACCGCTTACAACTAAAATCGAGTCGTTACGCGACACGCAACTCGCCATAAATCTACACAAAATCTCGCCGACCCATAATGGCGTAGTTCGGCAAACTCTGCCATGACGTTCGAGTTATGAGCGAAGCCAGAAATCCGTGCTATGAGGGCAACGATTGAACAATCTGAGTGAAATCGTTTCCATACAAAATTTTTTGAAAATTTTAGTCTGAAACTGCCTAAAACTCGAAAAGTTATCTATTTTCAGGTCTAATTTCTGAGGAATATTCAAAAATTGCTAATATTCTCGAAACAAAAAATCGGAGCCAATACATTTGACGCGCAAATGTTGAATTTTCAAATTTACAACCCACTAGCGGGATTCTGGCTTCCCTCATAAATCGCAGTGGCAGAGTTTGACTAGGCCATTTTTGCAAGTGTCGGAGAGGTTTTGTATTTACGGCGCGTTGTGTGTCACGTCGCGGCTCGTTTTCACTCAGTTGTAAACTTGTTGTATTTGCCCGTGTGGAGTACACGGAGGACTTCTTCCACGCGTTGGGCATTTGTCAATGGAGCGCGAAAATTCAATGAGAAGGCCAGAACCTCGTGAGAATCCTATACATTCTGAGAATGCGTATTATGCATCAAATCCGACGCGCAAAATATCTCAAAGCGAAAACTAGAGTAATCCCTTCTATAACCCTAATGTAGTGCTTGTGTCGATTAAATTTACGGGCTTTCGAAGAAGTTACTTTTTTAGTTACTTCGTATTTTTTTTCATTTGTCTAATTTTAATATTCTATCGATAAAGGAATGGGTTTTTTTTTATTTTTATTATCGAGCCCGTAAATCGACACCAGTGCTACAGTAGTTATCACTACGAGATATTTTGCGCAATATATTTATAAGAGTTGGCGGGCCCGGCGCGCCCGCCATTTGTAGGGGTGTAAGGCGAGTCCTTGCGTAGGTTGTGCGCTCGACTTCACGACCCTTAGAGGGTTTGTGAAAATTTCAGTAGGTCAATGGGATCCGGTCTTCTTGTTTTTTGAGTTCGGTTAGGACCAAAGACAGATGCACCCGATGGATAAATCTGAGTTTTGATTGTGGAGTTTGGGGAGGCTTTATATTAGGGGTCGTAGACGTACTATTTTGTATAAAATTGAGTATTTCTATTCGAATCCCGATTACTCACAAAAAAACAAAAAAAATTGACACTTGGTAGAATTGAACCAACTACCAAAATTTCTGCAGTCATACGCACTAACCACACGGACATGCGGACGGAGACACCTTAAACTGGGATGTAGGGAAGTTGTTCTGGAGGAAGTCGTCTTTCGATTCCGCTTTCTTCAATTATTACTATTTGGGGAAGACGTTCGAAAACCGTTTTAATCACTGATAAGTCAGCGGAAAACCGAATTTGTGAAAATGTTATCACAGGATTGTACTCATTGTGGAATTCCCGAAAAGGAGACGGACAGTTGAGGGTTATATCTTGTACACAAAGACAGATGTATACAATAAAACAAGTTTTGGCCTGAAAATTAAAAAGAATAATATCTCTTGGCCATTGCTAACGCGCCGAAACTTCATCTTCCATTAAATAAAATCAAAAACTATGAATTAAAAATACATTCCGCGAAAGTGGCAAAAAAGTGTTCAGGGGACCCAGGAAACCACTCCCCCCAGTAACATATTTTTGAATTATTTTTTTCTTGAAAAATTTTCCCACTGAACTTTTTACAAATTTTATGTCTCGATGCGCGTCTGGATGAGACCTACACGTTTTAGAAAACTAAGAAAACTTTAAAACTGATCGAGTTATGATTGAAAAAGTAGATTCTAGCAAAGATGGGAAAGTGTGCAAAATTTGGCTACTTATTCGTCTTGCTCGGCCGACTCATAGTACTTTTTCCAATTCTTGTGAGTTAAAAATCGTGTTCAGCGTACTTAGGTTTTACGTGGGATAAAGAAAGAAAAATATCAAAATAGATGAAGTAGACTTGAGATAAAGACGAGAAAACTACTTTTTCGGAACAAAATTTTTTGGCAAAATGTCATTTTGCCTTTTGTTTTATCACAACTTTTTTCCGTTTGCCGGACTTATGAACTCAAACTTTTTTTCAAAAAATCAGTCTCTCTGAGTAGTATCGTGCACAAGAGTTTGAATCAAAACAGAGCAAAACCCAAATTTTAACTCAATTAAAACATACTTTTGTGGGGGTAAAAAGAGCAACAAAAAAATTAACTGGGGCAAAAGCCGTCCTAGAGGGCTCAATTTTGAGCCTCCTGGAACTTAGTGCGCGTTTTCTGCTCCACTGTGAAAATATTTCTAGTAGGATTTCACAATATTAGAGTGTCATGAAGTGACACGGTTCAGGAGTTGTGAATGAAAACGAAGTGGGACATCGCAAGCTCAAAATAAACGCGAAAAAACGCGAAAGAGGGGTGGAGTCTGTACACTCGGCATTTATTAGAGGCTGCTTGGCAGAACCGACAATTATCAATTATGTATATGATACTATAAGAATTATATTCGAATTTCACGCTTAGGTTTTTAGCAGCATAGCCGCCTGAAGTTCGACATTTAAAATAAAAACACGAAATGTTTAGTACGTGACAGCCAACGTGGCAACAAATGGAATCTCATCGACAAGTCCTTCAGAATTGAATACCATGGAATGCAGCAATTGACGTACGATAAATGACCACGAATTCACGTTTTCAAGCGATAATTTTTTATTGAATGACGTGGTAGTTTGGTGGCACCTGAGCGCTGTTAGCCAAGCCACTGTTGGTAGAGTTAATCGGTAAACACCACCCGTCTCGGTTACTCCACGCTTCTACGCCGCTAAAATTTGGTTTTGCATTTCCCATTGGGTTACGTTTTTGAAACGGGTTAGAAATGTAGAAAATGGGCAAATTCTAGGCCATCAATTTTCCTTTTGCATGTGTGCAGGAAATTGGCTAACATTCTAGAATTAATTTTATAGAAAGTGAAATTTTCGCAAAATCAATAATCCGAGAAATCGATAAACTTTGATAGAATCTTGTTCATCAAAAACAGATAATGTCCGAAAAATTTCAGAAAATTATTATTTACAGTCTCCGTTCATTTCGTGGCCTAGAAAGTTATCGATTCTAGGCTATCGAAGAGTTTTTCCAATTAGATTCACGACCACACGTACATTTGCATGTAACAATTGAGCGCGACAGGCTTATTTGAAGGAAGTCGAAGATCTTCAAATTTTTCGCGACAGATCCGACACTGTGAGCTTTGTCCCGCCGAGTTTGAGTCCTGATGTTCCGATTTGCCATAAAATTAACCTTATTACCATCCTCGGTGCCTGATAAGAGCCCGTGACGACAAATTTCTAGGCAAGTTACTGCTCCGTTGGTTATCTGGAATAGATCGATCATTTGGAACTTGTCGATTTTAAGAAACATTTTAGTGTACTTTTTTATGGGCAGAAAACATTGTTTTTTTTAATATCCCTAAACAAAACTACTGATAATTGTAAAAAGATCAATTTTTTATTGTTTGAAGATCTTTTTTGAGTTCCCTAGCTACAAAATAAACAATTTTAGAGTTGCAAAATTGTGAATTTTAAAAATAAATTGCACAATTTTGCCATTTTTTAATGGTTTTTGTTAAACCGAGTTTTTCTGAATTCAGCATACATGATTTACCGCTTTTTGACATAATTAGACAACGTTTGATATTTGTCCAATTTTTTTCAGCCATCTAATGACTTTTTTTGGGCAACAAAAGAAATTTCCTAAAACGAAACTTCAATATTCTGAAATATTGTGAAATAGTAGATTTTTAGGGCTCGGAGATCAATTTTAAGTGTTATTCTCTGGCTACAAAATGCGGAAAAAAACGTAAAAAAGTTTCGTGGTACTTGTGGATTATACCCCCGCCATTTTCAAAATTAATACAATTTCCAACAATAATTTATTTCTTTAAATTAAACGTGAGACCATTTTTCCTTTTTTGGTTATGCTTAGGAATGGTTTTTTCGCCTGGATTTCCACACGTTCTTATTTAATGAGTTAAAATATTAACTTTTAAAATGGCGGGGGTGTAATACAAATTCCAAAGTTTCTAGGCCCCATTTGCTGGGCCACAATTTATAGGCTACAGTTTCTAGGACTTTCCCTGGGAACATTTTCAGAGTTAGGCCACATTTTTTAGGCCCACATTTTCTTAGCCAAAAATGTACTCACAAACTTAGCAACGTGGCAATTTCATAAAAAACCTCATACCTTCTTCTCGAAAATTATTTTTCGAACACATTGAGATATTTCCGGAAACGTCGCCGAGAATAAAGTGGGTCGATGAGTAGAAATCTGCAGAAATTGCACAAACCGGTAGAGGAATCGAGAAGTCTGAAATTCTTCTTTTTTAATGCAATTTTAATCTCGGACCAATCAGCGTTTTGCCACGTCTTTTTTTTTTCGAACCAATCAGAGTTTGGTGGGCGTGGCTAGCTGCTGATTGCTCAGTTTTTTTACCAAAAGGCCTACCGTAGAAGAAGAGCAAAAGTGCTCTCGCCTGGTTGATGGGAACAGAAGAAAGTTTCATTAGAGATACCGCCGAACATTAACGTTTTTCGTGAAGAGCTTGAAATCATTAAAATGATATTTTCATTTCTGAAATAATTCATTTTTAAAGGTATACGCCAAACCACCGTTTCCTCTTCGACATGGTACTTCTGCACAGTTTCCAGCGCAACTTTATCGAATTTGTGAAATTCCAAAAGCTCCTGTCCTAGTTCACCTTAGAATCGTCACGCACGAAATCGTAAAGGAGGTTTAGGACCTAAAAGTTTGAAAAATATGTCCAAATCAAACTGTGAATTTCTACGCCAATGATGGAAATGCTCGTATGAAAAGCGACGAGCAACCTGTGGCCTATTAATTGTGGCGTAGTATCTGCTGCTCACCTACAAGATGTGGCCTAGATAAAATGTTCCTAGAGAAATTGTGACCATGGCCTAGAAATTTTGGCTAACCGACATAGAAATGGTGGCCGAGAAAGTGTGGGGGCAAAAGTTTTTAATTTTCATTTCGGTTTTTTTTTTCACAAAATGGAGAATTTTTTGATTTTTTGAAATTGAATGGGAAAGGTGGAAATATTGCTAATAACCACCTCTTTGCTAATTGTAATATCCTTTTCCACATTCTCGCCGTACACCATCATGCACAGAATCCGTCTGAACTTCTTTATTTTCTTGAAAGTTTGCCACGCATTCTACGTCTCTGCTTTTTTATTTGTCTCTATCGTCTGCGTCTTCCGACGTCTTATACACTATTTCTCCCTGAGGCGGATAGGTTTTCTCGTGAACTGGAAGAGTATGACGTCTGCCATTATTAGCTGAAAATTTGAGTTAAAACTGCTCTATCACACTAAACACGACGACACTCGTGGCCGCGGAAATTGGGAAACTCGGCCACGTAACTTGGTTAAATTAATGAAGATATTATAAAAAACTTCCGAAAATTTGAAACATTTTAACTTTTTTTAAAAAAAAAACACATAATGTTCCTAAACTGGCTAAATGAACAACGCCGCGGCGGAGCTCTCCCGGTTTTCCATGCAAGCGAGAATGCGTTGAGCGGGCCAACGGATGTCAGTGGAGTAGAGACGCAGAGCAGTTGTATAAAAGGGGCGGCGAAGAAATAAATTTCTATCCCAGAGTTTAATCTGTACAAAGTTGTTTTTAATTACCGATGACCGAGTATGAGATTTGGTTTTCTAGGGCACGGAACCAAATTACGGCGGAGTAACGGTCGGTTGAAAATATCGCTTAAATGTTTTGTTTTTTCTATGAACTGACTGAAAATCCACGAGCGTTTGTTTTTTCTAAAATTAAGTTCTTACAAAAATCACCTGAGTGTTCCTTGATTTGTTTTCGTAACTTTTTTCTCGCCAACTCTTCTTTACACTACGGTTTGACAACACGATAACATGTCTGTTCAGTTGAAAGACTGACAAGAGTCTCGTAGTCTCTCGCGGACTAGCTGACGCCCTTGTGGTCTAGAATATTGAAAAACTTAGTTTCATTATTCCGCGAAATTGGAAAACTCGGCCATCGATTTTTTTCCCACGCCCTGGGGCAATATGCACTAGACCTTTCATTGTAACAAATATTTCAAAACTAAGAATTAAAAAAATCCGCTCCTACGCAATCTCCCCAGTCTTGGCGGACGCTCCCTATTTCCAGAACCTCATTTGAATAACTTGCTTCTCCCATGTGTTTTGGGATGGGATAATCTCTTTTTCTACCAATGTTTTCTCCTTACTTCTGTTTAACGGCTTTTTTTCATATTTACTGATTGAGAATAGGTCAAGTGACGACGTAATAGAGCGCGTCGAAGAGGAGAGACGCGTGGCCTAGGAATCTCTGCGATCACCACATGAAATACGTTTTATTTTCTAGGCATCTCGACCGTGCTTTGTCCTTCTATGTTGACAATTTTTTGCAAGTAAATTCCCGTCTGCAACAAGGACACCGCACACAACACAAAATAGGTGAAGGTTCGATCGGATCTCTTTTTTTCCAGAGTCAGACAACCAACACACAAATGATGTGGGTCTCTTCCATTTTCCGGTCGTCAATTTGTTCACTATGCGCTTCACTAATTCCTGCTTTGCATTTCAATGTCCGTGCCCTCTCGGGACTGGAACTGACTTTCACCAATGTTTCTTTAGGTGGAAATTTAGATTTGGATAATTGCTGGAGCCAAAATTTGGAATATTTAGCGACTTGACCGTGCAAAAATTTTGGTGGCCGAGTTTTCTCTTTGCGCCGGCCACGTTGAAATAGTCGCCAGGTGCAAGTTTTTAAAACGACCGAGTTTTCTCTATTGCTTGACGACCAGATCTCGCTTCATTATAGCTGTCCGTCTTCCCACTTGCGTAAAAGTGCGACGTGGCCGAGAATAAATGTCAGTGGCCGAGTATGCGACATTTTTTTAGTTTTTTAGGAGGTGCGGCCTAGTTTTTTAAAACCATTGTTTATCTCCACCCAATCTAAAAAAATTTCTGCGGATATTTTAAACCATGGCCGTAAAAAAAAGCCACTCTCATATATGTTTTCGACACCTTTCGGTTTTAGAAATATATTTTTAAAAATTAAATAAATGGCCGTTATTTGAAATCCAAATAGAAATAATTTTCCAAAAAAAGTGGGAAAATTGGCCACTTGAAATTTTTTCCGAGATCTTTTTTGCGAAAAGATTTGAGGCCTAAAAAACAAAAACTCGGCCAGTATTTTTTGACCTTCCATGTGACGTCACTTGTGACTTACAATTCCTTTTCTCAAGTTCCTTATGAGAAATCGTTTTTTTAAGACCTTTTGTGACCCTTTTGTTGCATTTTCTCCCAGTCGGAAATTACGCCACGTGGAAATAGTACGGCCACACTCTTATTTTATTCCTTTGGCGTCTTTTGGGACAAAGTAACAAGTGAAATTCAAACCATGTAAATTAGATAGCCTAGACTTAGCGACTAAGGCTTGTTGAAATATTTTCGTGGTGTGGCATAGAAAAATAAATATTGGGCCATTCCTTTTTCTTCTCATAGTTTTGTCAGAAGACGTCACTGAAACCTAGAAATCTCTGTTCCAGGGCTGCAAATGGGTATATCCTCCATACCTTCGTCACAGACCGGGATCTTCCACGTCATCGACCGCGCCGAACATTGCATTTTGCTAGAGATTACATGGACCACTAAGGTAAGCTGCCTAGAAAAATAGAAAGTTCGGCTCTAATCGATTGATGATGTTCAGTTAAAAACGCGAAAAACTGCGGACGGCGAGGCGACGATATCGATTTCTCCGAAATTCGCGTGACAGTCCACCAACTTATTTCGTTTCAAGGGAATATTCGAATTCATGCCACTTCTGAAATGGTAAGGCTTGTTTTTGAGGTAGGCCACGAAAGCGTATGGTTGCTTTTAAACACGGGCCGCGGACTGAAGTATCAAACTCGGCCACCAAAAATTGAAACTGTGAGTCGCCCTGATAGAATTTTTTTTTTTCTCGGCCAAACAGCAAAGGCCGACACAGTGAAGTTAAAAAGGGAGGGTGCATTTTTTTAAATAAAAGACTAGACTCCTAATGCAGAAATATCATATTTTTAAATGAAAGATCTAGTCGGCTACGTCCGCGGTCGATTGATACAGTAGTCGCGGCTCGGTTTTCATTGATTGAGCACTGAGAAGTTTCACTTCTCCAATTTCAATTTCAGAACGATGAACTAAGAAGTGGACTACGTGGCAGCCAGTTGACCTTTACCGGATAGATGGTCCTGTAAAGGAGGTGAACGTTATTGCCGAGGTGGGGGCTCTAGAGAAACATCCACAGCATTGGGCAGCCTTCGCAGGTCAGTCCCTAAAGAAGCAGAGACTAAAATGCAAAAGTGCTCTGGTTGTGAGATAACGGATGCGCCCACGAGAATTGTCGAAGTGTTCTGAGAGAACGTGGAGAATATCATCAAAAGCTCCATAATTATAAATATGGAGACAAGACTTTACCCTCAACCTATTTGGAAGACTGACTCATCTCCAACTCCTCGAGCATCAGGCGTTTTCTAACGGCAAACTAAAATGCGAGAGTAAACAGTAAGGCATGGAAAAGGCGATCACGCAAACGGAATTGAAGAATCGAGCGAAGATAAGTGATAAAGAAGACTAAGTATGAGAGTAAAGTACGAAATGATATTGGATGAGGAATCACCGGGAGAAGCTGTGTGATAAACGAGTGTTGTTGAAGGAGGATGATGGTGGATCGAGAAGAGCTTCGCTCTTATGATTTCTCAGTTCAGGGAGAAAATCAACATGAATCTGTGTTGATGATCATATGTTCAAGTCGGAGTGAGGTCTTGATTTTAATTTAATGCCTAAATAACTTTGAGACTGAGGCAGTTCAATAGGCTATATACATATAAGTCTGGACCCAACAAGTTTGTTACAATTATTTTTTCTAGATCCTCGTTAGCTGCTGTGAATCTTCGAGCAACGTCGTCTATCGTTCATGTGTGACAGTCGTACCTAGGATGTTTCTGAAGGGGAAGATTGTGGGCGAAAGACAATGAAGAAGATGATGGAGAAGGGGGCTCCGATGAGGAGGAGATGGAGGGGAGCCTGGTCTTGAATGTGATAAGAGTGATTAGGAGCATGTCCAGGATGTTCTTAGGTCTCCATTAAAATATCGTCGATGAAAAAGCTTAATTTTTTAGATGCTAATTGGCAAATCTATACTTCAACAAAAATAAGTAGTCCTTCCCGAAGTGGAATCATGCCGAGGATTTTGTTGATTTCTTAATTGAAGCGGAGCTTAATGACTTGCCAGTTCTCAAAAGAGCTTGTGAGAGGTATTTGTGCTGAGCTGAATTCGGTAGGCTTCTGTTCAAAAAAATATAAAAATCTAATCGAAATCTTTTCTAGAAAAAAGACATCGGAAGGCACCTGTCCCTGTTGGACTTTTCAACTGGATTGTATTCAACTTGCCTGTCTGGTTATGGAGAAGTCGATGACCGTGTTTGACGGAGTTGGCGAATCGAACGCAAGAGTTTGTGGATGCTGACACACTTTTGGCCCATATCAGGAAGAATTTAAGTGAGTAGGGTGTGAGGCAAAATTGCCGAATTTGCCGAGTAGGGCATATTGCAAAAAAGTAGATTTGCCTAATTAGCCGGGCAAATTTCGAAACACTTAATCACCAGTGTGTAAAGAATCTCAGTAGTTTTGGTGCTCCAAAAACATTAAAAAATATTTTTTCACTTTGTCAAGCACGGCAAATTTGCATTCCGAATTTGTCTACAGGTTCGGCAAACATTAAATAGATTTGCCGAATTTGCGGAGTTCGGCCACGAAATTTTGAGATTTGCCGCACACCCCTGGCGTGCACCGTGAAAAGTTCTTTTTTTCCAAAAATCTAAAACTTGAGGTTTATAATGTGACCCAAAAAAAAAGAAAAGAATTCGCCGCGCATTGCAAAACCATAATCCGCCAAAAGTTTCTTTGTTTTTTTTTCGAAGTGCAGACCGGGTTTCCTAAAGTCAAAATTGGAAACACGACAGGACTTTGCCGAAAATTTAATTTTTGAGTGATCTGTTGATGCGAAAGGTTATTATACGATTTCAAAAAGCTCGGTCACGTGTAATTTTAGAGTGGGATTAGCTATTTAATTACATTTGGGTGTAATGTCCAGTAACCTGGATAAAAGAATGCAAACGCTTTCGGCCGAGAATCGGAATCTTGTGGAGCGCATCGAAATGTGCTACGTTTCGTGACCAAAAAGCAAGAGTTCGCGTTGTACCGACCGCCAAATCATTTGATATTCGGCTTAACTATTCAATAATATTGTCACTGTTTTCCTCTCTTTCTTCTTTCTCATTTTTAAAAATGAATACTTTTTTCTTTTTTTTTACTTTCCACACGACTAACTCCACAGCCGCGCCTTTTTGTCTTTTACCCCTGCTTGCGATTCCACACATTTATCAAAGCTGTAAAGACAGCGAAGTAGGAGTAGTAGTGCTTTTAGAGTACACTTTTGGCAACTCTTTTCTCCAGATATATTATATGCTGTGGATGGAAACTTTCCCAGTTTATATATAATATTATTCATTTTACATATTCCCCTTCTTATACTGCTCACCATCCAAGGTGCATCTGATTACAGCTATTCGCCGGATGGGGCGAGTTATCAAAGCACAAGTGGGGCTCTTTTGTTCATTTTCATTGCTTTTTTCATTTCCTTTCGTTTCAACATTTTTCCATTTTCGAAATTAATCGGCTTTTCTGACCCAGGACTCACGGGAGATGAAAATAAATCTCCTTTAAGAATTGTGCTTTGAAAACAATATCATACAATTCAAACTTGAAACTTCATTTCTCCGTTGTTCCCCGTAAATTCCAAGCTGTCATCCATCAACTCTTTGAATAAAAAATAATCATTTGGTCCGTCCGTCGCGATAAGGATGTGAAAAAAGGTAATACCGGCATGTTGAAATACACATTTCGTCGCGGAGTATAGTTACGCTTCGATTGCTCAAGAGGATTCTTCTTTCCCCTATCATATTTTCGGGCAAAGAAGAAATCTCTGTCACCCCCCCACTAATAGAACAAAATGCAGCGTTCATTTGGTGCGATTTTCCGTTTCAAAAAGAAAAAAGTGTGTCAAAAACCTATCAAAAAGTAACCGCCTAAAGTTAGTTAGCACCTTTTTCCATTGTGAAGTTTTCTTCTTCAAAACAACTACTACAGTTTGTGTGTGTCGTCCTATTGTTGTGGTTGTAATTGTTCGATAGAGCGCGCACAAAATCTCTCGAATTAATTGATAGTGTGTTGTAGTGACCCTTGACTCCTTTGTCAACACCGTAATTAGGAAGGAGTACACCGCCGGGCGGGCGAGTACAGTTATTATAACGGTGGAAGATTTGTTTGTTTACATGTTATTAATAGGTTAGTTGTGTACTTTAAACGTTTTTTATTTGAAAAATATTCTGTTAATTAAAAAATACGTAATTTAGAAAAATGATGACTTTTTTTCACTTTTCAAATTTCTCAAAAACCGAACCCATGGGGTTTATTGACAAAAAATAAGAAAATTTTTCTAGTTATCAAAAAATCTATACATTTTAATATCTGTAAATAGTAAATGTGGAAGACAAAATTTTGACAATGCGTGACTAATGAATTTGAGTTTATTTAACTTAAAGAAGAGGAGTAGACGATAATCAACTATATATTGCGCAACATATTTGAACAATACATATATTTTTCGTAATATTTATTTTGAAAAATGATTGAAAATAAAACACGAAGAAAACTATATTTAAAAACGTCGGTGCTTTTTTTACATCCTGTTTTTAAACGAAAAATGCAAACCAATTTTCCGAGTTTTTTCTTCAAAATATTAGTCCCTGTTCATGAAAAATGTGGCATTCTCACTTATGTAAGTAGTTGTCACATGCACTTTTTGACCAAAAATTATTTTCCGAGTAAACCCTATAATTTCCAAATCCTCTTTTTCTGAAATTTTGAACTTTCCGCAAATCGGGAAAATGTCATTTCAACTCGAATTCATACTAATTATACATCTGTATAATTATTTAGATTCGTACTTTTTCCTCCTTTTGAAAAAGTGCACAGACATCGCCGATCTTTACAACCGTCTGGGCGCAGGACCGGTGTTGTAGGCATTAAATAACTATTTTACCATAAATTTCTTATAATTTTTAGCTGAAACGGTTTTCCAACAAAAAAAAACGCACATTTAAAAGGGTTACCGTATTTCTTCTATCAATATGGCTGCAATACTATTTTTCAATGGTCTTCCCGCCCTTGCAATACTAATAGGGAGAGCAAGACCATAGGGAGTGCAATACTGATTTTTCAGAACATTTTTCTGACTGAGCTTACTATTTTTTTTGCTGAAAAAACTCGAACCTTGTGTGAAAATTCAAAATTTGATTGTAATTGGAACAAAAAGGTGAGTAATTACTTCAATTTCATGCTCGAGAAATTCATTTCATTGTTGCACAGTAGGCAAAAAATGTTGTTAACATCTCAAAATTAGTGAGGTGATTTTGTACAAAAAGAAAGTAGACGTAAGACTATTAGGGAGTGCAACACTAATTGCGAGTGCAATACTAATTTTTCGGAGGGCGTTCAAGGAGCAATACTATTTGGGATTGCCAAAAGTCTAATGGAGAAGGAGGTCATATTAATAGAAGAAATACGGTTAATTATTCGCGAGGTGCATTTTCATTTTAAACTTTGTTTGAAAATCAATTATCTTTAAAAATCCTTTTCTTCAAATTTGTAATTATAAGAAACCAAAAAACCTTTATTTAATTTTCAACAAGTGTAGTTTATAATTAAAATATGAAAATTTACAATAAAAGTTCAGGACTGAATCCAAAAAAACTTTTTAAAAAACGAAACACCTTGTTTGAACCTGATAAGCCTGGAAATAACCTGGAAAAATAACATCGATTCAAATTTTGCAAATTTTAAGCGTTTTCTAACTTCGAAAAAGTTGACCTGGCAAAAAATAGGATTTTTCAATGTATTTTATAAAAAGGCGAAAAAAAGCAAATTTTTTGAGAAAAAAATTGCTTAAATTTTCGACAAATCATTTTCAAAACTATTCTCGATTAAAATCCGTTTATAGCCATTTCTCCTTCAATTCTTCCAGGTTCGAATACTTGCTCAGAAACTAAATTTGCTCTTTTTCGTATCCACTACTATACGACTAGTAGAAGTTCTTCATTCAGTGGGTGGCCGGACTACTTTGAATCAAATCACAATTGTAGAAGGAGGTCGTGCATTTGCACGGGTGTTCTGGTCACTCCAGAAATTGAAGAAATTGAGCACCTCAAGTTTTGGATTATTCCAGGCAACTCGGTCGTTTTTGAAAACCTATTCTATGAAAAACTGCAAACTATGTGGTTGCATCTGTCTGGCTGGAATTTTTGTTTCAAATTTTGACCCAGGACATTTGAGAATCAACCAGTTTTCTTACCAAGTATGCTAAAATCCGAGTCAAAAAGTGACTTACACGGGAAAGTTTCAATTCATTGTCCGTGAGGACGTTCGCCTGTCCAGCTCATTCCTTTCTTTTGTCTCCGCCAGAACCGTCTGGGGAGCTCTGGCGAATGAGTTGAGAGCAAGCACATTGCATGAGCTAGATACCTCCAAAAGATATGTGCAGGCGGGAGATAAATTGGACGATGAAAAATCGCCATAAGCATAATTTTGGTGCGGCGAGACCCGAATAATGAGACATTTACGACTTTTTGGAACATCTTCTACGGACAGAATGGCATTTTTGGTAATTTGAGTTGTAGTTTGAGGGGCTTCATTTTTTTCGATTTTTAAATTCGTATAGACGCTTATACGCAAAAACAGAGAACTGCTATAGGCGCACGTGTAGTCAAAATGTCTTTTTGATCTTCAAAAAATGCGGGAGTTAAGACGCAGACATATCATCTGATTCGCATGGCTAAGAGCGGGCTGACGTCACAATTTTCTGGAAAAATGTTCCCGCTTGTAGATCAGGCTATGATGTGTGTGAGTTTTCAATGAGACAGCCTGGCACGACGGTAGTCACATGCTGGCAGTTTTTTTCCTGAAAAAAGGTACCTGGATTTTCGTTTTTTCTTAAGTAGTCAAATTATCGAAAGCTACTAAGCTACGTGAGGAACTTAGGAAAAGTAGGATTTTAAATTGTTTTCGGCCTCGCAACGAAAGACTCACTACTATCACCTCCAAAAAACGAAAATATTTGTCGTGCCGAGCCCCAAGGCTCCGTTGAAGCGAAATTCCTAAACTCCCTAACCGCCGAAATTAATTTCTGAGTTGATTTTCCCATCACCTTCTATATACAGTCGTTTCGCCCCGAAAACGATTTGAATTCGGCTTCTCCTCAAATCCTCATTGCATCCTCTTTCTTATTCGATTTATTTCTAGCGGACTCTCCCCTTCCCATCCGTGGCGTTATTGTTCGGTTACGATACGCTTCTTGTGAAGGTTATATGCAAACGACTACTTGCCATTCGATTCTTTCTCCACAAACGAGGTTATTCCATTTACTTCAACTAAGGAGCTGTTTTTTTCTTGTTTTTTGTACCTACATTCAAGGTCCAAGTAGTGCGGAAAGTCAAAAATCACCTCGCAATTTAATTTTTAATAACGCCCGAATTAGTGCACGATAAGTGAATAAGAACAAAATTCTAGTCCCAGAGTCGTGACGATTTAGACAGCATATAAAAAAAACGATTTTATTCCAAAGTTTGAACTGCCACTACATTTCATGTATTGAGGTTTTGAATTTCCATCATTTAGTTTTAACCACACTTTTCTTCCGATTTCCACCGCAAGCGAAAGTTGTCTTGTTTCCGAATATCTGACCGCCATAACTTGGCTAGGTTTTTTTACGACCGTGCTGCCGAATTTTGAATAGTTTATCAGCATAGACACTCTCTCTGTCCCCTTTCCAACCTCGCAAACCCTTATGTCTGTAGTTGGCATCTGTTGCAGCTTGTTTTTGGGGCAATTTTTTGCCAGCTTGTTCTACATATTAACATTGCCTGACCCACATATCTTGAGCAAAATTCCAAAAAGTACGTTTGTGGCCTAGAGTGATTTAATTTGTGGTTTTTTTTTGATAGTTTTGAGCTAAAACTTGCATGGCTTTTTCACTGTTATAAATCATTTACAAATTCATTTTTTGCTCTTTTTAGAAAAAAAATTGTTAAAATTGTGGAAAAATTTCAAAAAGGTGTTAATCATTATCCACTTCCAAAACGTCATAACTTTGGTGAAACTGTACCGGGCAGCAGCTAAATTTTTCGGAGTGATCGACATTATTTCTCTTTTATCGAAAAATTACTATGCCAAGACCGGGGACCCATTTTTTCACTTCCCTCGCGGTATAAGCCGAAGCCTTAGTCTAAGTCTAAGCCTATGACTGATCAGCATAAGCCTCAGCCTAAGCCTAAGCGTAAGCTCAGCCTAAGGCGAAGCCTAAGAATAACGGGAAACTTTTTTTGTTGCTTTTTTTTGTTTTTTTTCAAATGCCGAAAAATAATTGCGGGATATGAATTATGACTTTGTTTAGCCGTTCCCAGAGATGCTGGTTTTCAGGCTACCATGAACCTTAACGATGTTCTTCTGCCCGCCCTTTGCACACTCTGAAGTTTCCCGCCATGTCAACCTTTTCGATCGTTCGGCACGATAACGTTCTGAGTCCCGCGGTGCCCGTTAATTTCCATCGAATCGTTAGGTTTTCTCCTTCGATTCCTAGCGATCAAGCCATAATTTATCCGTACAAAATCGGATTTTCTCCCTTTTGAGATAATGATGATGATGGCCTCCCTAGACACCTAACAGTGGAGTGATGAATGTCTTCCTTAACACGTGTCCGTTTATCATTTATCACTCTGTGCTGAAAACCGGTCTCTCTCTTCCCCTGACCTTTTCGGTTTTTTGAAACAGTGAAACAGAAACGGAAAACAGGCGGTGTCAGATGTTTGACACGTTGATGTCGTAATCCATTTCGTATTAATGGTCTGCTACTATGTACGCCATTTGCTATATATGGCCATATTTTCAATAGCTTTGAGCACAAGCTTTCAGAATTGGCAATCCATTTTTAAAATTTTAAAATCGTTTGAAAACCAATATATGGGTGGAGCCTATTTCTTAACTGTCCGTAGCTACCGAAAAAGTCGGAAAGCGCCGATTATCTAATATTTACGACTTCGGCAAAACTGAAATTCTTCAGATTTTTAAGATCTTGAGAGAAAGAATTATATTTCTTTCAAAAAACATGTATTATTTAAAATTCGTTTGTTTTATTATATTTGAGCTCATTAACTCTGTATCAAATTGACAAACAGATTATTTCATTCGCAAAAATGCCTAATATCGTAAATTTGAATGTAAAGGCAATTCCCGAATTGCTGCACATCTTGGTTTTTTGAGCTTATTAATTGAATTTTTAAGAACTTTTATTTTGGTAATCTAAATTTTAAAGTTCTTACTGAATTCCGAAAAAAATTTCTTCAGAATAGGGCTTCCATGGCGTCAAAAAGCTTGCCAAACCTTAAGACGACCTCCGCTCCTCTGCCTACCTTAATCTATGTGCTGAAACATATGCTTTTTTTGCAATTCTTGATTGTTTCCTCTAATTGATAGAAATGAGAAAATTTCATAAAATAGAAAATTTACGCACAAGTACAAGGATTTAGGCAGGCCAGGCCGTGAAACCCCGCCTGCTTACCATGGAAGCCCTACTGCAGAAAATGAGAATTCTGACTGTTCAAAAAAAAAAAGAAACCAGCCGTGTTTTTCCTTGAAATTCGAAAAGTTCCCCGATATTCCCCTCATTTCCGGAGCGTTGTGTTCCCATGGTGGAACGGTAGTTTCAACACACCGTCAAAAGCGATTATCGTGTCTATTTGTCTGTCGTCGACGCGACCCATCACACCAAATCGGTTGAATTGGCATGTCGCTACCCCTTTTTTAAATCGGCAATATATTTACTTTTTATTTGACTAAGAAGTAAACACTAATAGTTTTGACTGCAAGAATATACATAACACCTTATTTCACTTGGTAAAGTAATTGAACCGTTGTAATTGAGCTGAACATGATTTACCTACGAAAAAATGCCTGTGACCTAGGGCTTGCATGTATGGTTAAAAGGGCTGCCTGCCCGACCAGGCAGCATGCGCTTGCCTGTGCCGGTTTATGCTAAAAACAAGGTTTATGCTACGGTTGAAATTATTTTTTCATTTTTAATTTGATTTTCAACTTTTGTAATCTGAAAATTCACAAAGGTAGAAAAGAGGGGGAGGCAGGCAAGTTGGCACGGCGTCAGGCCCTGAATCGGCGCCACTGCCTATCATGAAAACCCTAGTCTGAAATCGATTTGGCCCAAAGACCAATTTTCGAGAATCATTCTCCTTCCGTCCTTTTTACGCACTTTTTTAATGAATTTGAAGTGAACGTGTAGTCGAGGGAAATTTAGTGAAACTACTACAAGTCCACGGTTTTCAGCAGCAACTTTTTTAATTTCGTAGAAATAGGTGCTTTTGTGTTAAAATTAATAATAGCTGAACTATTGGATAATGTACTTTAAGACGGGCAATGTCACTCCATATTTTATAAAATGTTGAAAATTTTGGTCAGAAGGGATCGACGGAAGATTTTTAGAAATCGAAAATTTTCAATTTCCGATTCCCATCAAACATTTTATAGCTCAACAGTTTATTTCGAAAGATACAAAAAATCAGAGTCATCTGTTCGCACACCGTTTTACCCCTATCAACAGATGTGTTGCCCTGCACATCTGTTAGAACTTCTCACTATTCTCTACAACAGATTTTCGGAACAGAAGGTGTGATGTTTCTACCTGACTATGAGATTCACGTGCAATTCAAAATGATTTTTTGAAATTTGGAGATTTTTGAGTTATCCATAATTCCGTCAAAGAGAGATCACAATTTTTTTCGTAGATTGACAAGAAAATTACCCCAACAATACTCAAAACAATTGTAAGTACAATTGCATTATTGCTCTTCAATTCTTAATTTGTGCTGAAACTTTCTTTTGACGTTAACCCCTGCAAAAATGCAACTAAAATTGATCAACACTCGTCTAGTAAATCTACTAACTCGCCAAGGGAGAAGTCTTTGAGGGGGTCCGTACATTTGGGGTTTTCATGCTAAAATTCCTACAGAAGAGTGTTAGTTATGATCTCTCATTTTTGCGCATTTTTAAAGTGACTTTATATTCGGGAACCTTCAGACAATCATTGTCCGCACTTTATGGAAATTTTTTTTCGTTTTCGCTCAAAATCACTAATTGATCAACTCCAAGCATAAAAAATCAAACCCCGGTTTTTTAACAAACATTTTGTTAGTTGATCATTTTTCAAAATAATTTAGTACTCTCAACGAAGTTATGCAACTCCAAACTTGGTTGAATCAGTATTTTGCACAAAGTTCGAAGTGAGATGTAGTTCATTCCGACGGTTTACTTGCGAATGGCGAGTTAAAACTTGTGTAATGTACCATACATTTCTGAACATTAAAGAAAGTTCATACATTTTTACAAAAATAAAAATTTTCCTATTTTTGCTAGGAGTTGATCAACAAATTTTGAGAAAAAAATGAAAAAAATAATTTCGAAAAAGTGCGGACATTCTAGGTTCCCGATTAAGAATAAAATCACTTTAAAAATGCTCAAAAATGTTTGAATGAGTTGTGTAAAACTTTACTTACAAAAATAAAAATAGAAGGAATCGAACCAAACCTTAAATATTATCAGACGCGCGCACTCCCAACTCGGCCACCGCGGACAATTTTCAACTGCGTCGATGTGGTGTCACCCGACATTTTTACTTCGGTGGTCACGCAAGCTGAGATTTGCGTGGACTGATAGTAAGACAGTCGATTTCAATGGGGTTCTATCAACCTAACTTGCTGAAACACATTGACCGGGGCAGCTAAATTTTTTGGAGAGATCACAACTCACTCTTCTGTAGGAATTTTAGCATGAGAACCCCAATTTCACGGACCCCCTCAAAGACTTCCCTTGTAAGTCAAACAAAAATTCTGAGATTTTTCAGAGTACTATACGTAGTATATATTTCTGAACAATTCCCTCAACAAAATCCTTTCCACTTCCTCATTTTCCCACGTAAAGTCAGAATACATTTTACTTATTACCATTAATACCTAAATGAAATACAGGTCGATCTTGCAATTCTACCGTCTCACGGCTTTTGTACTTGTTCACCGCCACTTCCCCCATTCTTTAATCCAACCACACACTTTTGGCACACAAAGTGTTCAATCGAAATGGGACACTATTTGCTATTGCTATAATCGACAGGCTGGTGGCAGGAGGAAAGCAGCAAACGACGAAAGGCATAAAACAACTGGGCGTTGTGTTAATCACCCGTATTAAGCATTCTATATTAAGCGGTCGACAAACAGTTCATTCATGTTGACTCGATTTTCGATCATTTCACAGAGTTTTGCTTCGAATTGAAGGTTCATGGAGAGATAGCCACTCTGTCTATTTTCAGATTCCGCTGAATTTTAAGATGTTTAATACTTATTTGCCACCTTTTCGACGGAATGACATGTACCGGTCGGCTAAATCATGGACAGAATCGATCTGCTAAGAGATGACAATTTTTAATGTATATACTCAGGGCTCAAATGATCGAATTGCGTAACGAATTTTTTAAAAACTTTTATCAAAATTTTCTATTGGTTCAATGTTTCGAAAAATAGACCGGAACATGTAATTCCGTACAAAAAAACGCGCTTCTATCGTGTCTGAAACAACAATCTTTTTCATAATAACTTTCAACTACAAACTTGTTCTTTACAAAAAGATCAACAATTCGATTATTAGGTGAGCACGCTGGTTTTCTGTACAAAAAATTTTCCGCGCAGATGTGATCTACCAAAGTAATTTGGAAAACCCGTCAATGCTTCGTTGCGTTTCAGTGCTATTTTAGGATCTTTGAGAGCTCACCTGCCGTGAGCTTGGCTCTGGAGATTCGCAGCTAAAAAGGAGTGACCGTTTCTTGAGGAGCCGTTTCAAGGGGCTATCGAATGGCATAGGTCTCATATGCAAGCCGATGGGCACCTTCTGACGGTTCCCTAGTCAGATAGAAGCCAAAATTTGGGCGAGGTATGCCCATTGTCATTCTAACGAAATGGCCTCCGACGTGATAACTTTTCTCTGTCAATTACTCTGGGCACACTCCCAATAAATCCTACACACCGGGGGATTTGAATTGAGTCATTCAAGTGTCAGTGGTTCAGTTTCTAGCAGTTGATACGTGTTGGGTTGTGTGGTGGTGGTCAACCTGTCGCCCGATCACTCACACACACACATACTTTTCCTGCCATATTCCTCCCCACGAAGAGAGAGAAAAAGAAGTTGCATCTTTTCTTTTCTATAAAAGTCTCTATCCACCAACACACCCTTATTCGCATGTTCTCGCACTCCATTTTCCAAACAACGCAATCAGTGCATCCAAATCTACATAATCGATTCAGGGGGAATAAACTGTGATAGTTTTCTAATACTTTTCCTTAATTGAAATTTTATATTTTTGAAATAATCGACCGAATATGCCTAATTATAATTAAAATTTAGCGAATTAGATTTGAATTTAACAACTATTGCGATGTTTTGAATTTTTGACCGGAGTATTTTTTCAAGAAATTCTCTTTGCTAACCATAAGCTGAAAAATTTTGATTTTCTAGTTTTTGGTTTGCCCGGTCAAAAAAAATCTGTAAAAATTTTGGGGCTTTTTTCTCAAAAAAAAAAAAAGAGATTCAGGAGATTTGATTCATAACTTCAAAACTTAGATGCAAAATCTTTTACGTGGTGTCGATTTTTTGATATTCGAAAAATCCGGTTATTAAACAGCTCTATTAAGAAAAATTATTTCCTGGACCTATTTTCTGAAGAATTCCTCGTGCTTATCCCACTCTACAATTTTTCGATTTTTCATAAAATTGAAAGTTTCGCCGTTCAGTTTACCCTTCAAAATCAATTTTCGACGATCCCGAATGTTCAGAATGTTGACAAATAAATTTAAGATTTTGTCAAATTTTCCCACACGTACTTATCCACCAAAATTGACAAAAGACCCTTAAATTTAATTTCTAAAATTTTCAAAAAATCGTGATCCATTCCTCCATGTCATGTCTTGCAAGCGTTGCCTCAAAGTCATCAATTGAGCTAGTTGTCATCAATTCAGCGATATTTAGAGATTGAAAGAATGAGTAACTCATCCTTGTTTCTTCTTCATCTCCTCACTTCACTTCCAATTTTCTAGGTCATCTGTTACTCAATTTGGCCTGGCGATTAGTCATCTATTTGTTCGTCAGACTTTGGTGCAAATTGTCGTGTCACTGAGTAGTTATTTTTTCTTTTTGGTTGATAAGGTTACCTGTTAAGGTCATATCCTTTTTGGCCTATTTTTCCAGTAGTATGATTCCTCTAATGGTCGTTTAGAAGTTACTAAATGTTTCGAAGTTGTTAAAGTATTAGATTTTTTTAAAATCATTAGGAATGTTTTTTTAATTAAAAACAGTGTTTACAAAAAAAATTTTATGTTTTAAAAACTTAAAATAAAGTTTAACAAATGTCTAAATTGTTAATTTTTAAAACTATAAACAGCATTGGCATTCATAAAAAACAAATTTCGACAAAAAATTCGTAAAAATTGCTGAAATCGCAGTAAAAATACTCACAACGCTGAATTTCTCATAAAATCTGGAAAATCAAGTCGTTTTACTTGATATTCGATGCCATAGGAAATTAGACAAAAAAAAAGTGATTTTATTAAAGGCTGGTCAAAATGTCAGATTTCAACAACGTTTTATAAAACCGCTGTCAGAGTAGAAAAATATAGGTGTAAAATGTAGTTAAAAACTATTCTTCGATTTTCCTTATTTTTTTCTGCTAAGTGATTGAAATTTTCACGTGTAGAACAAGAAGATTTAAATTTAAACCAAGTTTTTAAATTTTCAATTAAACATACAAAAACTACTATTTTCGAAATTTTTAATACAACAGTTTAAATTCCAATTTTTCTTTAAAACATATTTTCCAATGCTGACTCTGAATGAAGTCTTAACACTTCAATTTCAACATTCTGTTGCGACAAGTCGTCCCATCCATTGACCGATAACAATGGATCAATCACTGACGAGGGCCCCCGGGCGCCGCCATCATTTTCTCTCTCTCTCTATCTATCTGTCTCTCTCTCTCTCTTTGTTTCTAAAAAGAAGGAAAATGAGCTGCAATTTATCAAATCCACGGTCTTTTTCCCTCAAATTCTCTGCCGTCTCTAGTCTTCTCTCATGGTCATTGTCGCCCTAGGACATTTGTGACTCACAAAATGTGCCGTATTATACAAAAATAATTAAAGTTCAATGCGTATGCGTGGGTGCATTTGTTGCATGGGTGAGGGCAAAAATTAGCCACCCACAACAAACTTAACGTTTTTTTTTTTGTATTTTGCCTTTTTCTTCTTGATGAATGGTGCACATTACACCTGTTCTTTGTTACGGAAAATTGGGCGCAGAGAACTAACTGAGGTGTGAATACTTTGTTGGTTTTTTTGGCTATACCTATTAGTAACCTTTTGAGTATTAAAAAGAAAATTTGAGGCATGTTATTTGTCGAGTTGTTGGTAGGATGTTGATAATTACTGTCATCGTGATATTCTATTAGAAATTAATATTTATTTACACGTTTTAGAAGAATTGGGGATTTTTATGCAAATGATCCAAAATAATCTTTCGACAAATCACGACGGCCCACACTGTTTTTGTCTTCAGCCAGCAATCAACGTATTCAAACTCCGCCTACTCTGTCTGATTGGTAGGAAAAGTGGGCGGAGCAAATTGCTGATACTTTTTCGAAGTTCTCGACCCTTAGCAATACCAGAGTTCATCAAAACTGAAATATTGCGTTTTTAAAGGATATATTATTAGTATTATTATTTACTCTCGATTTTTTTATACTATTCTGTGGTTGCTCTGAATTTCAGATTATTCGAGATAGTTTTCGATAAAGCGACAAGTGATTGTTCAGTTTCTGATTTCCATAATTTATCCTCTAAAAGGTCAAGGTTTCGTTTCTTTGCAAAAAACTCATTTTTTTGAGAGTTTTCGGAATTTTGGCTAGCCTCTCCAATAAATTAATTCAAAATTTCGGAAATTATTCTTCCATTATATCAATAGTGTTAATCTCACTATTCTAATTTGATACAAACAAATTGACTCTTCATCGATTTCCAGCCAAATACTTTACATGCTTGGCAACTGAAAATTAGTGTTGTTTTTCAAATTCTCAGTTTCCAGCCACTGAAAACATGAGCCTCCATTGGGTCCGTCCCTCTCCTTTAGCCCTTCCGAAACTCATTTCCCAGTACTCTCTCCAATCTGGTCAACATTTGAAAGGCTGTTGGGGCGAACGAAAGCCAATTAACAACCGAACAATAGTTTTTTCCAATGTCATCGAATCCTGGCTTCTCATAGCCAAAAATGCTGATGACTCGAAATTGCTTTTCGTTTGATATACACACACATCATCCTGTGCCACACACTCTTTTCCCCACTCTTTTTCACGAGCTTTTTCATTCGGAAGGCGACAGAGATCAATTACCGACATATGGAACCAATCGAAGTACTCTCTCCGCTGCGACTACCTAATTAACCCTTTATTGAAAAAATGAGAGAGAGACAGAGAGAGGATATGAACGGAAGAAGGAAAAAGAGGCAAAGCAATTGTTTATTGTTTTTCGAAACAATTCAAACTTTTGTTTGGGCTGTACGCCTTTAAAGATGGAAAAAAAACGGAAATTTTCCAGCAATCCGTAAATTTTTTTGTCGGCAAATTGTTGGCATTGGTAATCGGCTAATTATTCGCCGATTTGCCAGAAATTCATAATTTCGGCTACTTATGCAGGTTCGCCTATTTGCCAAAATTTTTCATTTTCGGCAATTTGCCCGTTTGCCGTTGCCGGAAGTGTTTAGAGGAGTTGTTTATGAGACGGAAGCACTGTGCCTGTTTGCCAATATTGAAATTCTGAAATTTCCAAAAAAATGTGCACAAGCACCGCCAAAAACTTTTTCAGTTGCCGGTTTGCCGGTTCGCCGGAAAATTTAAGATCCGGCAATTTGCTAATTTGCCGGAAAAAACCGGCTACCGCCCACCCCTCCACCGAATTCGGAAATTTTGTAAAAAACAAGTTTATTTTTGGGCCAATACGATACTACTTTTCCTAAAGAAGCTTACAGTAATCAATGTATTATCTTTTCCATCTCGAATGGTACCTGTGTTTAACGGTCACATAACTGTGACGAGTACTTGAGATGACAATACTCTTATCATAAAACCTCCCCGCTCGTTATACCCCTCTGCTTCTCGGGTGTAGGGTTACCGTGGTTGCTGACGGTTTCGTAGGGATTACTGATGTCAGAGAATTGGATGAGTAGTTGGGATTAGGAGATTAGGGAAATTGGAAGACATGTCTATGCACTCCATATGTTTCTAATAAGAATCCTTGGAAATCGAATTGCATATAACTCAAGAATGGATAGCTACTGGTCCTGTTTCGTTTTGTTATCTTGATTCTTCGAAATGGTGCTCACTCACTCGAAGCCCCAGGACGCTAGTTATTTTCGTAATCGTCGCGTTCGTTCTCGAGCTCCTCCTCGAGTTGGAAATGTTAAGTTGTGAGGGCTATCGCGTCCACAGATTTATAGAGTCCGTCGTGCGGTTTCGCTGGGTTCTCGCAGCAACCCCCTCCCCCCGGCACCCACGCAATATCGGTGCAATCGCGTAAACTTTTTGGAGCACGCAGCACACAATGTGCGCGGCTCAACTCTGTCTCACTCTTCGGACATCCAACATATGGCACTCCTCAAAGTGTTCACTGGCCTCCGCTCGGAAGTCAGGCGAATTTATTCATCTCTTTGGAGATTGGCTCACAATTTTTTTGATTTGAATTCAGTGACTATTTATCGATTTCTAGGGCTTCTATGTAGGTTGCCTGTGTGCCTGTCGTCTGACGTTAAGGCGTCCTCCGCCTGCCTCTTCGCCTCAATCCGTGCCTTGTGCCAAAACATACGAATTGTAAAATGATTCTCAAATTGATAAAAATGAGAAAATTAAGAATTTGTGAAATTCAGACAGGCGGCAGGCAGATCTCAGACAGGCATCAGGCTCAGAAAACGCGCAACTGTCTCCCATGGAAGCCCTACTGATATGTAAAGGAGATATTCGGTTCAGATAAAATAAATTGAAGTTACGCGAATTCTGAATTTTGAATATTTTCCAATAGTTTCTAATAGTATGGGTTAGATGTTGCATTCTAGATACTTACAAAATTTTTAGAAAATTCCGTGGTAAAGTTCAAAGGACACTCTTTGGCTCTGAATATTGGTTAATAATATGAATCCGTTCTGCTTTGTTTTCCGTACTCCAATTCTTGACGTTGATATGAAGCCAGCTCGAATAATAGCCTCGCACGTAGTCAGGCTGTCCCAATACGGTTTGATCGACAAAAAATGCTGGAGTTGCCCTTCAAAATGTGACGTAAGCGCGCTCTTAACCATGCACTATAAAATCAGTTGAGAACTCTGTCAAATCAGCTCCCGCATTTTTTGGAGATCTACGTAGATCAAGCCGAACGGATACTGGTACTCTGTCACCACGAGCTCCTAAGCACTATTGTGCAAGGACACGTCTTATTTTCTGAACCGTCAAAAATTGGCACCGTTTGAGAATGAAAAGATCTAAAATTTTCTGAGTCTGTATTTTTTTCTGTATATAAGTCCTACCGAAAGGGTCCCCCGCGCTAATAATTACCCGCTTCAAAACAATGTGTACTACTAGCCGAGATAAGAGTTTTGTTGTCATGATACAACAAGATTTCGATCACCGCCCATTTTTCTTGTCAAAAAGTTCCGCTTATAATCTCGTTTTCTGATAATCAGAGATACTCTATGGGAATTGGTTGAGATCCACGCCATTAGTGAATGTTCCCCCAATAACCATGGAGCGTTAGAACAAAGACGAAAACCCGCCAGAAGACACACATTCTCGAGAGCAGGAGAAAAACGAAGAAGTGGGAGGGGAGCCCGCGGGGGCCGAGACTTCCCACTTGCCGATTTGTGCAACGCAATATCGATGAGGAGTGCTCCGTCCATTCGATACAGTCTTGCACCATGTTTGTTGAGAAATGCTATTTGGGTGGCTGGCAGAAGTTATTGGTCCAATTTTCTTGTCAATTTGATCTGACAGATTATAGGTTCTTGGAATTCGACTCTTCACCGAAAAAATCGATAATTTTTCGGAGTTTGTTCAATTTTTCAGTTGAACATTTAAAAGTTTTACTAAATTCGATTCTAAATTTTAAAGCACATTTTGACCTAGTAGGACTTTCGGAATTTTGTAGCCTGTATAAAAAATCGGTGGCCAATTCTATAATTTTTTTTCGTTTTGAAATTGCCTTTTTATGAAGTTTACAATGTGGAACATTCGACTTTGAATGACTTAGTTTTTCAAATTCCACCTAGGGTCAGAGTGTCCCATCCCAGTTTAATCGACGTTGATCTACAAAAATCGCGGGAACTGGTCTGACGCAGAGCTCGCCACTGATTTTGGCAGGGTTAAGACTTGCTGACAGCACATTTTTTCCTGGAAAATTTTCCGCATTTTTTTGTAGATCAAACAAATTTGATATTGCCTCGAGTTGTTCGCTATAGTTGGCTAGTTTTGAAATCGTTCCGGAATTTCTTGAACTTCGAGTTCTTGAAACATTTATGTTTTCACCAGTTTTCTCTGCGTGTTTTTTGACTGTTCGAAAAAACGGTTCTTAGAGACTGCTTTGCAAATTTCGAATTCATCCAAAAAAAAGTGAACAAATTCTTCGTATTTTGCTTCTAGAATTTTTGGAAATCTCATTTAAAATGAGTTTTTGTGAAACATTTTAATCTTTAAATAGTCAGAGTTACGTCAACCAATTCTATTTTTTGAGGAAGTTATTTTGAGAAGAAATACAACAAATCCGCAATTTTTTCCTTCCGAATAATTAACACAATCCAAGATCCCCCCTCAAACCGGATGGCATTTATTCGGATCCCGGCAGGTGTTCGAATGAGATTTGTATCCATTAACACATTGTGCATCACATAGACACATTGTCAACGTATGCACACAACAAAATAACTGCGCTCGTTCGCACCTCAATCCTTTGATGTTCTCCGCCGGGGGCTCCTGTAAGGTCAGGAGTTTTCTAAAAATGTTGCCTTCTTCTCCGTCTTCTTCCTCTTCATCATCGAATATTCCAGAGGGGGGCCGACACGCTTCACTTGATTTTCGATGGCAATTTGTTTGAAGAATTCATGAATTCGAAGAATTTATTTGGGAATACTCTATTTTGCTTTACGTTTACATCCAACTTTTGGCAACTTAAGCGCCTCCAACTGCAACCATATGGTGCTCAATGAGCCGAGAGGGATCATCTGTGAATTTGGTGTTTTTTATTGGTTCCCTATTTGATTGGAGAGTTCATTTTGCATACAATTACCTCTATTTGGCTCAGGGGTGGACGGGCACAATCCGTTCGGCATTTATATTTTTGCCGACAACTAGGGCAAATCGGCAATTCGCCGATTTGCCGGATTGCCGGAAGTCTTGATTTTCGGCCAACCGGCAAACATCAGCGTCCTATTTTACTATTCAAGATAAATGTAGGAACATTCATAGGATGCGGATACAATATTGCCGATAAAATTTAAATTCTGATCAAAAAAAATGAACCACAATTTGCCGCAAGTTCTAGCCGTTGCATTTCAATTCCGGCAATTTTATGTCCGTAAAAAATTGCCGCCCACCCCTGATTTCTATCAGTCTGTCACCGATTCTAGTGAGCCGGGGGGTCTTCCATGCAGGATGAATCGGTGTCTGCTACATTAATTGCGCAATCCACATTGATACAGAGCAACCTGCTTGCAATTGTTTTTCTGTGGCCCGTTCTGGTTACACCTATAAAAATGTGGTCGAAGAATCGTATAATTTGGGTCATGAGATGGTCCCTGGGTAATTGGAGAAGTGCCGTTGAGAGAGAGAGAGCCAATTACGTATGAGGTCTGGTTCCTCTGCACTCGGGAAGACGCTATAACCCTTCGTGGAACTTTTGGCGGGAGATATCAAGAGATATTTTCCACTTCGGTAATTATCGCACTTATGGTACTCTCTTTGTGAATGATTTACCTATAATTTATTGAGCAGTTGTGATTATCCTATTTTGAGAACCTAGAAATGTCATAGGAAACGTTTAATCGGTGAGTATTGTTTTACGTTAAGTTGCTCCGTTTTTTATTTGACTAGCTCGACACAGCACCTTTGAATTTTACATTGGTTTTGGCCAAAGGTTTTCTGTTTACTTTTATTTTGCAGTCTTATTGATCTGGCCTGCTTTACCGAGCTAAGCCTAATCCTGTCCCGGTTACAGTCCATAAGACAACATCAGCTTTTGAACTCAATAATTGCCGAATTGCCAAAATGCCAAAAAATTACGATTGCTGCCCGTCTGAGTAAGTCTGAAACAGTTGTGATTGAGCCGAAACCTACTCGGAGTGGGCCACTTCCCTATTTAATTTCTCGGTTGATTTTCACACTTCCCGCCGAGAGCCCGCAAGCATCTGCGAGCTGAACGGTTTCGTCGTCGTTTTTCATGTCTATTGCTAAATAGGTACGTGCGCGTTACACACTCATAAACATCAATTCTTTCATAAAGTGGTGGATAAGTCGAGTGGATTGCATCTGACACCACACTTCCGATAATCGCTTCGTCTTCTTGTCATCATCGTCGTTTTCTTCTTGTTGTCGTCCGGTCCCCACACACACAAACGGCTACTTCCGACGCGTCGGTGTTGTGTGTATGTGTCAAACGGCACCACCACAAGTGATTGCCCTCGGCCGTGTGCTAACTCGCATTTTGTCTTGTAATCACGCAATAGTGATAACAATCGTTTCCGGACCATTGCTAATATAATATATTGGGGCTACTGCGGGCACGTCTTGGCAATAACCTGGATGCAAGTTTTATCGTTAAAATGTGAAGCCCATGTATGATTGCGAAAATCCTAGTTGAAGTTTTCCCATTCAAATAATGGCATATTTGAAACATTTCGAACTTGAAGATTTATATCTGTCGTAAGTGGAACGGTTCATTTGGTTTCTTGCGTCTCGTCGCGAAAAGCTTTCACTATGGTATGAAGCACGAATGGGGAAAATCGAAGTCGAAGGTCGGCTCGATTTCGGCAATTATCGAGTTCAAGGTTTCGGAAAAACTCAAAAATAATTTTCAAATCTATTTATTAGTTCTGACACGCGGACTCGGCAAGTCCCATTTCGCTTTGATCTACGAAAAATGCGGGAGTTGAGAGACTACCGCAAACATCTCAACTGATTTCGCATGGTTAAGAGTGTGCTGACGTCACTTCCGGAAAAAAATACCCGCATTTGTAGATCAAATCGTAATGGGATAGCGACGTAGAACAGACTCGCCAAATCGATATATGCATAATGAAAACTCTAGAACACTGCCACCCTCATAAAGTGAGTGACAAACATTTCTGCTTTGAGGAACTATAGAACCCCCTTTCAAGTCGATCTTCACGAGCGCAAATTCTAGAAAGATCTGACAGTGGCCGATTTTTTAATGTTTCTAGGCCCACGTAAAAAAGCTATCTGATGCCTTGTTACATTCCAATTCGAAAATATCCCTTTTTTTAATTTTTCGGCAGCAGCCCGGTCCGTGCCAACAACTTACTAAACCCTTCAATACCCTGCCCTCCAAACTTCTGGCCTCCCGGCTCCGTGTTGTTCAGGGTGTTGTACCCCCCCTAGACACCCAACTGACCATTCACTCGTCCTCCCCCTCTACAAGAACCACCACCACCTGATCCATTCCGCAATTATATTCCGGATACTTGTCATACAGAGAATACCCGGTTTGCTGCTGCCAAACGGTTTTCATTTACCATTTCTCACTCCTTGATTGTTGTCTATTCTTCGATTCGATGCGGCAAAACTAGCGCCTGGTTTGGGATTGCTTTAATAGTAAAATTTTTTCTTATTTAAATTTCCTATATTTTTTGTATAAGATTTTCTTTTTTAATTGCCAATCCATGGGAACGTCTCAAATTGCATAAAATTCCAATTTGAATTCCCTCCAAGATTTCACGATGGAGCGCACTTGAATTATTATAATTTTTATCAATGAATTTTTAGAGTTATCATCTCTGACTGATTTTTTTCTTTGTTAGTAGTTTTAGAGGAAAAAATCCAAGTTAAATGGACATTTCCTATTAGTTTTACAATTTTTGGACTACTTTCCCCGCCGCCACCGCTAAAAATCCCAATGCAAGTTTTCACCTGCTCTTGCACGACTCATTTCCGCGAGCGCGCGCGCTCGTACTTTTTATCTTTACTATTTATATATCTCAAAAAAAAATCCCGTTAATTTTTTTTCCCTTACAATCTCATATTTTACTCATTTAGTTTGGCTTATAAAATGCTAAGATTAAAATTTTTATATTTCATTTCCAGATCACATACACAACGAAACTGAGGGGAAAAAGTTATTCCTGATTGATTTTTATGATTAGTAAATAACATAGTTCGGCCGCAGCTAACGGTGACGAACGCCCGCAATTATGAGTTTTTCGCTTAAACATCAGATCTTTTTCGAATTTACTGTGAAAAAGCGGGCGTTTTGAATTTTCCGACTTAAAACTGCTTTTTTTTGCAAATCCCGACTTATTCAGAGAAAAATAATTCAAACTCCATTTTTCAGCTGTAAATGTGCTCCGGATCATTCCGGTGGAGCCGACGTCTAAACTCCTATTATGCGACTATTCTTTGAAATACACGACAATTACAACTATTGCGTCGTCGAATTATGATCAGGTTGCTAATATTCGGTGAGGTTTTTTGATTTTTGAATGCAAAATTTGAGTTTTAAAAATGGAAAAAATGCGATTTTTAAATCAAGATATCGGAAAAAAAAAATTTCCAAGAAAATGGTGGTTTTTATCGGGGTAAAAAAATATTAGAATAGAAAATTTGGATTTTCGAGTTCGAAATGAAAAAAAAAAAGTTTTGTTTTACACTAAAATCCCCATTAAAATTGGAATTTTTTTAAGAGAAACATAATTTTTCAATTTCTAACTGTAAAAAGCACACAAAATTTCTTGAAAATTGGCATTTAGTATTTTTTACACGAAAAATGCATTAAAATTGAATTTTTAAAACAATTTAAACTTAAAAGCTTAAAAATTTATTCTACACCGGTAAATGACGAATATTCAAATAATTAAAACTTCGAAATTGTAAGTTAGAAAAAATCAAATTTCCTCCTTATTCTCAATTTTTTTTTGACAGCAAAATTTCAGTTGAATTTTCCCATAATTTTGAATTAAAAATGTGTTTTATTCCAAAAGAAAACTATTTTACAAAAAACTAGATTTTTTCCCAATTTTCTATGAAAAATTTAATTTAGGCCAATAACTTATTTTCTTTTTCCAGATCACTAATCATATCTTGTGGTAATAATAATTTCCAATTTCCGGATGCCTACTTCAAGTCCTTAACCGCGTTGCATCATCTGCGGATAGTGATGAGTTATGATATTATCAGCTGGGGGTGTACAGAACATCTGCGATTTTTGCGTGGAAATTTAGAGGTCAATTTTCGGAAAAATTGGAAAAAGTGGGGCCTAAATCTCAATTTGAAGTAGATACGTGTTCAAAACTTTCAAAAAATTCAATCAAAAATTCGATTGGAATACTTCAAAAAAATTTGATTTTCTTCGCGAAAGCCGGTAAATTACAAAAAAAATTCGTTGGCGATTTTTTGGTTTCCTCTAGTCAGAAAAACAAACGAAAATTTTAATTTTTAATTATCGTTTTAATTTTTCCAAAAAAAATTTTTAAAAATACATATGTTCATTTAAATTTTAAAAATATCGGAAAATATTCAAAAAATGAACTTTTCTATCGCAAATTTAACAAGAAAAACTGACGAAAAGTTCTTTCAAAAAATTAAAATTCTTCTATATCTTAGAAAGGCTAACAGTTTTCCCATTTTTTGACTCTTTGAGCAAATGTATCACGGTCTCATTACCATAACCATCCAAAAAGAAAGATGTGTCGTCTTCTATTCATCCTCCTCTCGACACCAAATTCTTAAGATGAGCCCCAAGCCACTCGATGTCTCTAATTAGGCAAGTGCCCCGTGCGTCATTTTGCCATTTGTACGGCGACATATGACCTCCGGTGTGCTTGGAGGACTGCGAGAGAGGAGGATTAAGGGGATTTTTATGTTCTACAATTGATTTTTCTTTAGGTCAAAAGTAGGGATTTTAACGCCAAAAATAGAGATTTTTTAGGTCAAAAGTAGGGATTTTAAAGCAAAAAAAAAAATTTTTCGGCCAAAACAGTGGTTTTTAAGGAAAATTTAATTTTTCCGTTTATGACACCTAAAATTGGGGTGAAATTTTTTTGGATAATCTAAAATTGCAATTGTTAATTATTCCAAGATTTTTTTTTGCATTAAACGTTATTGTAAATACATTGAAAATCACTTGATCCGAAAATTTCATTTTTTTCAGAGAAATATGGTGTTTTAATAAAAGATGTGTTAAAAAACCTAGTGCATAGATATATAGATAATTTTGTACTTGAAATTTGCAATTTTTAACTTCCGACCCGAGTAAACAGAATTTAAATCCAATTTTAGGTGAACGGAAAAATCCCAATTTGCGTCTTGGCCTTAAAAAATCCAAATTTTTCGGCCTAAAACTCCTTTTGGCCTAAATCACCCTATTTTTACCCTAAAAAAGTCCCTTGTTTTTCCATCCCCAGGAACACGTAGATGAACACGTGTTAGGCGTGAAGAGGTTAAGACCATTAGCCATGTACAATACTGGAGTATAGAAGGGCTAGAAGTAGCAGCAGCATGGGGTGCTCCAAGAGCACAACCTCAACAGATGTATAAAGTGGTTTTTGAGTAGATTTGTGGTTTGCACTCGGTGGAAAATCTGAAATTTGAATTTTTTAAAGCCTCGTATTTTTGTGCTGAAAAATGTACATATGAAAACCGAAATTTCACCACCCTTTAAGTACGGGAAATCTCCGGGGAAAAGTGGAGCTCAAAAATTGCATAAAAATGGAGATTTTAAAGCTAAAAATAGCTATTTTAACAAGATTTTTTGCAGGGGAGACCACATTTCTCTGTGAAATTGTTCGAAAATGTGGCCGCTGCGAATGATTTGAACTCGATCAGGTTTTTCTTGGAAAATCTAGAAAATTTTGCTGAAATTGGCTCAGAAATGTCCTAAATAGTAGAATTTTTCATTACATTATAACCCTCTCAAAATAATATTAAGTAAAAACAATCAACATTTTTTCACAGATCTACACCGCCTCAACCTCTTTCGAAATGACCGAAGACGTCCTAATGCCGTTGGCTCGTCTCCTCTCGTAAAGATCTCCCCCACGAGATCACGGAATATCGAGCTTCCACAGCGACTTATGATTTGTGCTCGCCGCATTTACAGGTATATTTTTGGGTAATTGATAATTCGCCAAAAAGAACAGCAGCCGAAAACTCAAATTTTTCACGATATTTGCCGAAAAACTAGATTTGTAAAGTAAAAAGAATGCAAGAATTTTTAGCTTAAAAATCTCAATTTTGAACGATTTTTAAAGCAATTTCAGTATGAAAAATCTATTTTTTGGGTAAAAATTTGGTGAAAACGCGTTAAAACCTGCATTTTTAAATTCGCCAAAAATCAAGACTTTGTTTGTAGTGAATTTTACTGTAAAGAATATTGTGTACCTATTTTCTATTTTTATGCGTACTGCGCAATATATTTGAGCGCAAAATACCTCCCTTAGCGAAAACTACTCTTCAATGACTACTGTAGCGCTTGTGTCGATTTACGGGATCGATTTATAGAATATCACAATTAGAAATAAATGTGACTGCGAAAACAAAAATTTACTTCAAATATTGAGTCCGTAAACCGACACTACAGTAGCAATCTAAAGATTTACTGTAGTGTTCGCTACGAGAGGACTATTTTGCGCCTCAAATTAATGTGTTGCGCAGGATGCATTCCCATCTTGTTCTCTACATTACCACCACGTCTCACAGAGAGGGAATTAGTTGTTTATTAGTACGTGGGGGGGGGGGGGCTTTAAAGCTTTCTACTTCTTCTTTCTTTCCGCTTTCTGACGTACAACCATCTGGTATTCCTGGCGGTGGGGCAATTGAAAATGAGAACAAAACATCGATGGAGGGAGAAGAGAGCTTAGAAATTGTGATCTAAGAATCCGCGCGGAAGGAGGACGTCAAATATCACAAGCGACGGAAGTTCAGCCAGAAGCAATAAAGGCCTAATTAATGATGATGAACAACCTCCCTGAAAGAGAATAGCGAAAATGTGAAGTTTTTATCCCATCTCAAGGAGCGATTTTTTAGTGATCATGGAGGAAGTGTGCACATAGTCTACGTGCCAGAGGCCCTATGCCTGCCTTATGCCTACTCACATGCTCACCCAGCCAAACTCTCATCAGAGTTCTACATTGTAGAATTTACAACACTGGAGTTTTATCCTGCCGTAACGTGGAAAATAGGCACCCTACGAATACGTGCCTGATCAACATGGATGCCATATAGTCCAGGCTGTATATTCGTAAAACAGGGGGCTATTTTTTAGGCTCATGGGTTTTTGTCGGAGAAAATCGAACATTGAGAAAACCAGAAATTTTTCAAATTTTCGTATATCCACGAATGCTATCGTTTCACCCGATTATCGAATCTCCACGTCGCTCTGTAATTTTAAGTTTAGTTAGTCCATTCGCCCAAGAAACTCCAAAGTTACAAATGCTTAGTTGTAAGCATTTTCAAGAAACCAAGAATTGCAGTTCCTGGCATGTTTTGGCGCATTCAATAATGCCGCTAATAATAATAATAGCATTATGCCTCCTATTATGATGTCGCGTTGTCATCGTTTGCTTCATGCTGCTCCGACATATAGCAGCTTTATGGGGGTTTTCTCCCTCCGCATCAAACGAAGTTCCTCTCTTCAAAATGATGATGGATATACATATATCTATGTTTATAGAAGGATTGAACCCCACACTTTACATATGAATAGATGGGGACCTTGTTACCTTGACTACATTCGGGAAGAGATTGAAGGTTCCAAAGACGGCTGGCTGTGGCTCACTAGGCTAAATGATGCGTGATATTATTCGCTACGGCACGCCTCTATGATCCAGGTATAGCAGTCTCAACAAGAGTCACAGCCAACAATACTCCGCTCCGACTGTTTTGCGGCCAACTCCCAGAATTTCTATTTGAAATTCTAACTGGGTGTTGCAGATGGGTCGAGGAAATAAGATAGCAATAATAATTGTTACGTGGCAATTGTAATCCGTCAGATATCGTCTCGAGACATGTTGACTCAAGAATGTGAAAATGGACAAATTTGGAAAATAGGTAGCGGAAAATTTTCGCAAGGTTTGAAAATTTCGGTGAGCATGATACGATACGAACTTTCCTCTTGATTTTCGCAGCCCGACAAGCCGTACGCGTACGCAATTTGTCTACCGTATACCTGGACGTTCAGGCTCGTCTATCTCGAGATGGTCCAGGCAAGATTTTTGTGGGGCATATAAAAAAGGTCAGAAAATAAAGTCTAATATTTTTTGGGCCCTAGCTTGTTTCGTTATCACGCGCCCAAACCTGATCTACACTCAAATTATCAGTCGAACGCATTTGCATGGATGTACCACTTGGCTTCCGGGTCGTGAAGAATTTTGAATGGAAAATTCGTCTCACGTCACTCTAGTGAAACTCCGCTTCTATATGCTTAACTCATCAAATTGAATTCATTTTCGGATAAGGCAGTTGAAAACAGTTGTGTGTGTGTGAGTGAGCTCATCCTTCATAAAATGAATAGAGATAGAACACTGACACTCTCTCAAAGTCAAGAGGAATTAATAAATATGAGAGCTCATTAGTTGCTCTTCTCGTGACTACTAATTAGGAGGGTGGTGTACATGAAACAGTGTATGTGAAAAGGGTTCCCCGCCGCCGCCGGCCAATGTCCTTGGGTATATGGCATATCCGACGTGGTGTTTCTCGTTTTGAAGAGAGTATTAGGATGCAACGTATCAAGGAGAGACATAGTTCAAAGATTGGAGGATTTGAGATATATTAGGTGTCGAAATAAATAAGCAGGAAATAAACCTAGAAAACGATCTACTTAAATAGCAGTAGTTATTTGAGTTCTTACTGTAGTCTGTCTTCGCTAAGAGATATCGCGCGAATAAACTGCTCTACGTACGCATCTTCTCATGATTTATCCCGTAATATAAACATGGCAAACATTTTTAAAAATATCCTCAATGCTATATTGAAATTCAAATTAGTACAAAGAAAGCAATTTTTCGATTTTTTTAACGAGAAAACTAAGTTTTCATCGCTCAAAAAAAATATGTAGATTTTGATGAAAATAATATGACAATTTATTTAAACCTATATATTTTTTTCTCATGTCCAAAACCACTTTACGAAAAAAATTTTTTTTTAAATAAAATTATTGGATTTTACGTCAACTTTACTAGAGATAAATTCCGAAAAATTAACAATAAATATAGGAGAAAACAATCCGACATTAACGAAATTGTTCCCGGTTCTGATTATCTCGTACCCAAATCAGCTTCCATCACTGCGAAGAGAGGAATCGGGTGTGTCGCTCAGCAGCTTCTGATCGTCGATTTGTCGAGAACTCGGCTCACCAACATCGAGTAAGGGAATATCCGGATATTTTATAATTTTGATCTTTAAAAAATTTGCTTGTGAAAATGTGAAAATCTAAAGTGAAACCAATATTGGTTTTATTCCAGCTATTTAATACCCCAGTTAGAATACTTTGAGATTTTTCCGGTGAAAAATTGAAAATTCGAAAATTTAGATCTCAATTCAGGCAATAATCCTACGTGGCATCCCGCAATCCGGCAAATTTCGGTGGCTTACAACTCGTCGCAGAGCTCGATTTATCGCTGGCAACTCCATTTCCACACCAACTCGATGCTGAAGCCAATCGAATCGTCGACTTGACGTCACCCTACTTCCAGGCATGTTGTACACGTGAATTTGGCTGGAAACACGCTGAAAAGGGTGCCGGATGCGGTAGCCGAGCTGGCGTTGTGGCGTTAAATGCGTCGAGAAATGAGATTGAAGCCGGAAATCACAATCGTCGGTTTTTTAGTGGGTTTTCAGATTTTGTTTTGGAAATTTGAAATTCTGAACAAATTCAATTTTTACAGACAATTTTGCGTGAATTATTGATCATATTTGTTTTAAAAGAATCGAAAAATTTAAAACAAATCAAATCTCGCTTTTCATTGGAGAATACATGACAAAAGTATTTTGTTTCGAAAAAGAAAAATAGCCAAAATTTAATGCTATTTTTTTGAAAAACTTCGATCTTAATTCTCTTTTTGAAAAACTACTGAATAATTTCATCAAATTTGTTTTATTTTGATAAGATAATCACGTGAAAAAATGAAAACAGCAAAATTGAAAATCAGACAAAAGAATAATCAGATTTATGCAATTTGGCCTGAATTTTCAAAAAAAAAACTGGATTTTGGAAAATTTCATCAAATTCTGTGTATTTTCGTGCAAAAAAAGATAGCTATGAATGTCCAATTTTCGACCTTATTGAGAAAAATTCGTAAAAAATTGTAGAAGAACGTTTCAAAATCTCGATTTTCTTCTGACAATAATTCTCAAAATCTTCATATTTTTCCAGCCAGAACTCGAAATGCTCGACGCCTTACGACAAATTGTACAGTCTGCCCAATTGCTTCAAAAATGCGATACACGCATTGGGCTCACCTCCATTTGGAGCACAATTCGATTGAGAAGGTGACTGGTGGATTGCTGGCGTGCGACTAATTTTCCTACAGACGGTTCGTAGACTTGTTTTTTTTTTTTTTCGTTTTTTGAAAAAAAACACGGTGAAAAATAATAAAAGCGAGCCCAAAACATTTTTGTTTAAAAAATATGAAAAATTGTTCAAATTCATAGGTCCTCCTTCAATATTTTCAACAAAAAAAATATTCTAGAGCTTCCATGGAGGCAGCCGCGGTTTCAGGGCCGACGCCGACCTTTCGCCTCTTTTTTGCATTTTTACGGGAATTTTCAAATTTCAAATTTTCCCCATTTCTATCAAATTATTGAAAATCAAATTAAAAACGCGAATCGGCATTGAGGCGAGAGGCACGCAGAGGTTATTGCCTTAGGGTCAGACAGGCAAGCTTTTTAACGCCTAACGTAATTTTAAAACCTGAAACATAGAACTTCCCCACGTTTGATTCCTCTGAATTTACTGCACCTCTTCATAAACAATGTATTTAGATCAGTGTAAGTTTTAAAGCTGCTCTGCAGTGCCCAAATTAAGGACTTTGCTTTTTTAGACCAAACTTAGTCCTAAATAACCGAATTTCGTAATGAGACTTTCTGAAAATTTCTCGAAAAAAAGTTATGGCGGTTCAAAGTTCAGGAAAATAAGGTAAATTTTCAGCTAAAATCAAAATTTTTAAAATTTTTTATTTATCACTTTTTGATAAATATTGTGGTCTTTGATTAGGCGGGGCACCACTAAAAGTTACATTTGCCCCACTGACCATGAATGTATTTAAATCAGGACGAAAACGCCTAATTAAAGACAAATATTTATTAAGAAGTGATAAATATAAAATTTAAAAATTTTGATCTTAGCAGAAAATGGGCTTTTTTTTCTCAAACTTTGAACCGCCATATCTTTTTTTTTGAGAGATGTTCATTACGAAATTCGGTAGTTTTGGACCAATTTTGTGGAAAAAAGCAAAGTCTCAAACATTCGGTACTCCACCTTTAAAGATTCTATACTGTAATTTTTTTTTATTTTCCAATCAGTGCAACTCCAATACTCTACTTATTCGATTCAATAAACTCGAGGCACAGTGTTTTGAATAGGCGATCGCGTGTCAGGTTTTAACCAAAATAGTCATGATGACCTTTTGTTCACCTTACAGAATCTTCTCAGGTTCATGCACACACAGGTGTCATTTACTCTTTCAAGTGTATATGTGTTATCCCGGAGTATCTAAGATAAACGGTAGTTAGACCACCCTTGTGGTGCGCGTAAGTTGTTCGTATAATTGTAGGGGTGGGGATCTTACCACATTTATACGGCCCCCCTCCTATTGTATTGTATTGCTGCCACCAGTCGTCTTAGAGAATCTCTTTGATTACGGGGTGACAGAATCATACTTTTTGGAATGTGTAATAGGTGGGTCTCGAATGGATATTGAGCACTAACAGCTGTGAAGGGATCCGATGGTCTTTCTAGGGTAACTTTCCACTATGCAGTCAATATTATTAATCTTACAAGGAAAGGGTTTTAGTTTAATACTTTTAAGACATGTGTGATTTGAAAGTGTTCCATAAGTGTATGTCACTCTAAAATTTCAGGCGGCATAAGCTCTAGTCTCAAACCCTCTAGCATCTATCTGAAAACGTTTCAGTGCGTTTTTCACTACTTTGAGGCAAGTAGAATATCTCCAAAATGTTTTTTTTGCAAATCTTCAATGATTTTAGAACGTTTAAAAGAAGGAAAACAATCTGGGAAAATTTTGGAAAATTTTTAATTTTTTGAAAAAAATCTGAAATTTCTTGGACCTGGTGGCGTGAAGAAATTTTCAGATTTTATTCAAAACTTAAAAACTTTCCAAAAATCTCCCAGATTGTTTTCCTACTTATAAATGTTCTGAAAAACATTGAAGTTTTGCATGTTAGTAGGGAGCGATTTGGTAATCGTGTTTAAATTACGTTACACATAGATAATAATCAATTGAAATATACAATTCTTAATTCCATATAACCTGAAATTGAGATTAGATACCTTATACAACAAATAGAATGTCGAAAGTTGTCTTCAGCAGACCCCCATTTGTGAAAAATGCCTTCTAAATTTTATTTTACACTTCTCCTAGTAGATGAACAGCACCTGCCAATCATTTCCTTGACAGCCGGATGGTTGCTCCTCTAAGACAGTATAATCCGGTCTCCCCCGGGGGGATGTAGGGTGTTGTTGCAAATAGCTTTGCGGAGCAGGTGCTTTTTTAATGGATTTAGCTTATTGGTGACGGAAAAACCCTAGAATTGATACAATTTGGTTTTCAAGGGGATTTGGGGAAGGGTTTAGAGGGGAACTGAAACTTAGTAGATCTTCGTCTGTCGTGGAGATCAGAAGATTGGAAGTACTGGGTTTAAGGGGGTCAAGGAGTACTGTAGCGCATTTCGACTACTGTACTTTAGATAGTTTTGTTATTATATCAATCGGATAATATATAATCAAGTTGCACCAAAATTGGAGACATTCTAGTAGGCATTTTCTTTATGCTAGGTATGTATAAGTTTCTACTAAGTGTATAAACCTACTATGTACCTAGGGGGAGTAGAGTTTGTGGGTATTTGTTTGCTTAAGTGCAATAGACTATAAAACGTGTCCAAAACCACCGAATTTCAAACTGAGATAGAACTTCACAAAAAATTTCCAAAATTTTTTTTATGGAAAAAAGAGCAAAATTTAACTAAAATCCGACATTTGGCACAGTTTTCTTTGTTGTAGCACAGCCGCGGGATTTGAATTTCTCGGAAATTACTTTAATCCTACATAATAATTTATCTCGAAATTCGTTGATTGAGACAACTTTTAGGCCGATAGGCATCCCATCTTGATCAGGATGCCTATCGGCCTAAAAGTTTTTTAATTGCAGAAAAACTAAAATCCAGCTGTACTGTGACAAAGGAAAGTGTGCGAAATCCAGATTTTAGCAAAATTTGACTCTTTTTGTTCGAAATTTTGAGTCGCCATAAAAATTTTTGCAAATTTTTTGTGAAGTCTCATTATTAAATTCGGGGGTTTTGTACTAGTTTTCTAGTCTGTTTAAGCTAAAAATACCCACAAACTATTACACTTTACTTTAACACACAATAATTCACTAGCATGGTGTAGTATCATGCCGGAATTAATATAGGATTGATTGAAGAGCGAAATTTTAAATAGATTATTGCAGACTATCTAACACTATTTGTATAAACTAAATTAACATAGTGTATTGAATAATGACTTTATTGAAATTAATACAGTTCTTTTGATATCCCCATCTTCTATGAGTATCCAATACTAATATGTCATATGAATTTCACTTTAATTGTTATTTCCCATGCGTCGTGTTTATACAAATGCTTTATATACTCGAATAGTCTAAAATCCAATTAAACTCGAGCCAATACAGAATATAGAATGTAACAACACTTGTGTTAATATTCTAATATACATGCACACACACACCCACACACCGGTTTTACACCAGTTCTACTAATATTTGCACAATACCATTGAGATAGCTGAAGTTCCATAGATATGCACGGGTTCGTTTCCGGCACTGCCACGGAAAATATTGAAAATGTGCGGTTTACGAAAAACAACAGAAAAAGCGATTTTCCAGAGAAATACGAAAAAAAAGAAAATATTTAGAAAATTAACAACAAACAAAAAAATTTTTTTTTATTAAAGAATAAAATGTAGGAGTTCACTTCTTTTTTTCCCCTTTCGGTTAAACTAGGGCTTCGATGGTAGGCAGGCGCGCATTTCAGGCAGGCCTGCCTGAAACCTGCGCTACGCCGGCCTCAGGTCGCCTTAAGACGGCTCCTAACAAAAATTTGAAAAAAAAATTTCAAAAATTGAATTTCCGCGCTTTTCGAATTTCTAGAACGCTTTTTTTTAATTAAAAAAAAATTTCAGTTGGACCTTTCATCGAATCAACTTCGAGTTTTTCGAGACGAAGTACGAGAATTCAAAAAATGGAAAGAGACTTGCTGTTCCAACCACTCTTTGGAGCTCCTCGAGCCGTCGGGCCTTGAGCTTGAAATTGGGTAATCTAAATTTATACGAATTTTGCAAATTCTAAAAATCCTAATTTTTTCTAGAATCCCTTGATCTGAGTCAATAAGCTAGAACTGCCCTGCCGCAATTGGGAAAGTCTAGCAGCTGAAAAAAGTGGATTTGAGCCATAACTAGAATTGCGAAGGTTTATCAATTTGTGCTCAATAATATTAAGCAATCGCAAGCATACTGTTGATTTGTCGAATATCAGTTGCAAAGTGTGAGTTTTTTGTTGATAAAAATTATTTGAATTTTTTCTTTTTTTTTAATTATTAATTCTGAGTTAAAATTCATCGTAAGTTCCGAAAATTTCTAGAGTTGAAATTTAAATTTTTATCCAGAATTTAGTCGATTATAAAAACGGAAAAAATAGGGATTGTCGATTAAAAAAATTAATTTATTTTAAAAGCACACAGTTTCGATAAAAATTTAATTAAAATAAAAGTTCCTTGCTAAAAAACTATTTCCTCAATTTTTTTTCTGAAATTTCACTCTTTCATTTTTTAATTCTTTTTTGTCTATAAATACGAAAAACACGAATTTTCGATAAAAACGCATTTTTCAAGTTTTTAAAATAATTTTAACTTGGAATTGTTCTTTAAAAAATTGTTTTTTATCAAATTCCAAACACATTAATGCATTTTTTAAAAAATAATTTCTTTAAATCTTCCAAAATCGGTTGTAATTTTAGCGAAAATAACTATTTCTTTCAGTTTTTATTTAAAAAATCCCTCGAAATTTGAATTTATCCAGAATTTAGTCAATGCAAAAAAATATACGAATTTTCGATTAAAAAAATTAATTTATTTAAAAAACACTCTCGAAAAAAAAATTTTCAATAAAGAAACTAGTTCTTATAATTTTTTTTTTCAGATTCACTTTTTCATTGGCCTTTTTAATTCAAATTTGAAGTAATCTGCAATTTACTCTATAAATACGAAAAAAATACAAATTTTCGGCAAATGAAAAAACACTTCAAATTAATAAAAATAAAAAACATATACTAAAATTTTAAAAAATAATTTCTTGCAATTTTCCAAAACCTCGAAGGTTTTAATCGCAAATAACGATTTTTTCAGTTTTTATTCTTTTAAAATTCCCTTGGAATTTGAATTTCTCCAAATTTTTTCTTGAAGTTTTTAAAATTTCCATCATTTTCTATTGGAACTTTCAAAAAATGTTCCTATGGCAAAAATCTTTTCCGCTAATTTCTACGTAAAAATTCTGCCAAAAAACAATGACAGTTCATGTTTTTTTGTTAAATAAATAATTTTCTTGTTTCTATGGAATTCGATCTTTTTTGAGTTTTACCCCAATAAAATGTATATTTAATCTAAAAATATATCCCAAAATTCCAGATCGGCACTACATCTTCTCTGACTGTTCTGAACTTCATTCCCTGGACGTGTCGAATAATGAGATTTCACTGCTGTACAAGCTTTTGCGAGCAACAAAGCTGAGGAAAATTTCGATGAAAATGAATAAAATTAGTGAGTTGAAGCACGAAAAACTGCAATTAATATTTTGAAATTTTTGTGTTTAGAAACGAAAATCGAGATAATGTAGGCTTAAAGTTGCTCAAAATCCGCAGATTTTTTGAAATCGATTCTGAAAAGTGCACAGGGAGCTAAATCAGACTTCAAAATTTTCAAATTAATTGCATATTCACTCGAAACCCTCTGAAAACTGCCTTCAACTTCCTATATTAAATCAAATTTTCTTTCAGATCCCTCGACAAAGGTCTCGCACAGAAGCTTCCGGCCTCCACGTCTCGACGTAACTCATAACGAGATCCTCGTGCTGAAATGGTCGGCATTACCTGAAAACCTGGAGATTCTCAACGCTGATAACAATGATATCAATCCCATGACCGCCGTCCATGTTCCCAAGCACCGCAAACCTGAAGTCCGTTTCGCTTTCCAACAACGGCATCACCATAATGACTGCGGACCAGATTCCGAATTCGCCGAGTCGCTGGACGTGTCGAATAATCGACTTGCAAAGCTCGGAAGACAGCGTTGGCCGCGACAGTTGAGAAGGCTCAACTTGAAGGGCAATCTGCTTACCGTAGTGGCCTCCGAGTCGATAAAAGTCGTAGAGGCTGTGCATCCGTTGAAAGTGGAAGTCTCGGAGAATCCTCTGATCTGTGATTGTCAGATAGGATGGATGATTGGTGCGAAGCCAAGGGTCCTCATTCAGGACTGATCTCTGAAACCGCAAGCTGTTCCCATATATGGCCGGTGAGGCATCAGATACAGATTCAAAGTCTCAGCAAGAAGGATCTACTGTGCCCATACAAAAGTGTATGTGAGCCGAAATGTATCTGCTGTCAATACGGAAATTGCGATTGCAAATCCGTATGTCCCGGAGCCAATTACCGATGCTTCAGAGATCAGTTTATCAACATTGTCAGATGCCAAACATCAATGGTGCCCAAAAGAGAATTCGTGGTCTCCGCGCCCCCGGTCTCTGCGACAGAGATCATTCTGAGCGGAGTCACCCTTCCACAGCTCCGAACTCACAGCCTCATCGGAAGACTTCGTCACCAGAGGCTTCATATCAATGGAACCGGGCTCCGATCCATCCAAAAGGTTCCATACTCTTCCAGCACTGAAGACGCTGGATTGGCAGTGTCGGATAACTCTTTGATCTCGCTAGAGCGAGGGGGAATTTCTAGTGGAGAAGTCTCGCACTTTCAATGGAAATCGATTTCTATCCCGTGGAATCGTCGAGAAGGTTCCGAACTTGAAATATCTGGCACTTCATAACAACTCCCTCCGAAGACATCCCTAAACAGGTGCTTCACTCGACGGCGCTCTCCAAGATCTCCCTGTCATCGAACCCCTTGACATGCGACTGCTCGGGAGGATCCCAACAACACCTTCAACATCGTCGTGACCCATGAAAGCTAATCCATTCTGGTAGCATAATGCGGCCTAATTGAGTGGTTCTCGTTGCATCGGCATTTCGTTGATTTCTCCAAGGTTGAATGCTCGGAGAACGCCGCGTGACGAACTGGGCTTCCTGACGAACGATACGCCAGTGCTGAGCGCCTATCCACCTAATATGGGAAATGACGTCTTTGTGATGCCTATTGAAGGTTGGTTTATTGAAATTTTTAAAAAAACGCGCGTCAAATTAAATATTTTAAAGTCTTTGTTCGAAAAATAACCATTTTACAATATGTAGGATATATCTATAACAGCTTCTGTACAAACGTAATCCAGATGTTAATTTTTTTAAAAATGCGGTAAATATTATATTGATTACATATTATTATTACACCGGTGTATTTTGTTCCACTACTACGACTTTTAAGGGGGGCGCATTTACGCGCGATGGTCCCAGCATTAGTCTCGCCACGCACCCCAAAAATCAATGGGTGGCCCGGACACCATCGCGCGTAAATGCGCCCCGCTTTGATAGTCGTAGCAGTGGAAAAAAATTCACTTGTATAATTATTAGTCAAATGATACTTGCATTATGATATTAGAAATTAAAAAATTGGGTTTGAACATTTTTTTTCCTCAATTTTTTTACGGTATTTCACCATGTATGCGTTATAAATACAAATATGATCCCTACCTTTTTATAACTTTAAAATAACTTTGTAAAAAGGAATATAATACATGCACAAGCACCATAAAATTTCGACGTTTGCATTTTCTGGTCCGAATTTAGTTCAATACGTTTACTTTATATATCACATATACAAAACAATATACTGAGAATGCGTATTGCGCATTATATTGGACGCGCAAAATATCTCGGAGAAAACATACAGTAGTCCTATAAATTCCTACTGTACTGCTTGTGTCGATAGAATATTAAAATTGCAAAAAAAATTTAAAAATCGGCGAAAAAAAACCAAAGTATAAGGGAATATATTCAAGCTATTCCAAAACTTTAAATCAATTTCAAAAATCGAGCCCAAGAGAAGGACTTACTGTAGTTCTCCTACGATTTTGCGCGTCAAACATGTTGTGAAATACGCATTCTGAAGATGTAGTGTACTCGTAATATATATTTTAACAATTCAAACATTTCCAGAATTCCTGCGCGACTACAACTCAACACTTTGTGTTTTCTCATCTGGATTCTTTGGACAAGACCCTCAGAATAGTATACTCTTTGTCATAATAACTAGATTGCTGTTCTCCTCTGCGCCCTCGTTATTCTCGCAATTTTATTCGAAAATCTCACGACGCAATCAATCAACGAAGATAAAAAGCATCATCTCTAAATTGTGCAACATCTGCCGGCTCGTCGCCTCTTCCGGTTCCGCTGTTGAGTTAGCACTCATCTTTGTGAGCTATTCGAAGAAGGACGAGAAAAGGGTGATTCATCAATTGTGTCGACCGCTGGAAGATGACGATTATCAGTTGTGCCCGTTGCATCGGGATGTGCCGACTTGTTGCTCGAATTTACGCGATATCTGATGAACTCATAGCTCAGACGGACTCGTCGCTTGATTCTTGTGTTGACTCAACATTGGAAGTGGAAAACGCTGCAGATTAAAGACTTAACAAATTCAAACTTTCAGTTTAAAATTGCTACGTATTCGTAAAAATGATGTTAAAATTCCGAGAATGCGTGTTACGCAAAATATCTTGTAGCAAAAGCCACTGTAATTATTTTATATGACTACCGTTCAAAATTACTATCCAAATATTTGATTTTTTGGCATGTTTTAAAAAATTATTTACGATGGAATTTACTCAAATATTGAAAACAATATTATCGAAATTCCCGAAAATTTGGTGGAAATTGAAAATTTCAATTTTTTCGCTAATTTTCGAGAAAAAAAAAATTAAAATTTGGATTATCTGAAATAAAGTTCCCAAACATTAAATTAAAAATTTGTTTTTTAAACGTTGGATTTTCCAATCTCGAACCCTCAAAAATTGAGTTTTTTTGAAATTTTTTTTCGGACAAAGTAAAAAATGCTCGCAAATATCGACAAAAAGTGGAAGTATTTTTTTAAGTTGTAAAATTGTTGGAGATTTTTGCAATAAGATATAAAAAATCTGAATTTCCATTCAAATCTTGAACATCAAAATCAGCAAAAAAAATTGCTATATATTCATTCAAATTAAGATCTAAAAAGAGTAATTCGCTATTTCAAATTTTCAAAAAAAAAATAAATTTTAAGTTTTAATTTTTGAACACTATCAAAAAATTTGTTTTTAAACCTAAAACTGATAATTCCGAATTCTCTGTAAAATCTCAAAACAAACATTCCTAGCCAAATTTAATCGAATATGATTTAATAATACTAATTTTAAATCATATTCAATTACATTTCTAGGAATTATTTTTGCTAGTTAAAAGTGTATGAAAAATTAACACTTTTTGAAAGAAAAACTGTTCTTATAGGATTTATAACACCGGAAATTCACTAATAACACTCCACATTTTTCCAGACCTCCCACCAACTCTTCCGCCAAAAACCGTGCAAAACGAGGTGATCGCCGTGCTCGGCGACGGTGTGGACGCGAATCTGCTGGACGACGAGCTCGGACAGAATCTACGGAAGCACACGAGAATCTAGATGCGGAGCCATTTACGGTTTATGCACACTTTAGCACGCATCACTTCCATCACGACTTCGATTGCGCACATATCTCGAATAGTGGCGATGATTCGTCTCAACTATGTTCGGATTGGAATTGTGCCCGAGTGTTGTTTAGCTTACAGTTTTCCCGTTTAGGTCACAGAGTATTTTTTATCCTCTTCCAAATGTACGAGCTTCCATTATTCACTTTCTTTTTCACCCCCAATTCTGCTGTGCACAATTTGCCATTTTTTGAATTTTTACAACAATACCGGTACTATTTTTCGATTTTCTTTCTTTTTCTCGCATGAATCTTGCCATCACTTCTCTAATAATTGACCAGCGATTATATTTTTGATTTAACATAATAATTGAATATTCTCGTTTTTCAGTTCAAATTATTGCTTTCTGTGTCACCACAAATTCAAATTCTCGTCCTAACCTCGTGTGATCTTCAGTAATATATATAGATTAATAATCGTCGTTTCTTATTGTTGTCATTTGCGGATGCTTATGAAGCTTGTAATTTTTTGTTTTGTTTTTTTGCCTGTTTCAGCTGCAAACTAAAATTCGGTAGAAATTCTTGAAAACACGCAAAAAATGAATAAAAGAAATAGTATATTAGCTTTCGAGAGGAGTTCACAAGCGGGTGGCACATCTCCGCGGCCGCCCAGTGGTGTACTCGTCTCGGGTGAAAGAATTACTTTATAATCTGTTTTTCGGCCTATTTTTAGTTTTTCGCAACTAAATGAGTAAATTATCTCTTAAATAATGTCGAAATTAATTTAATTTACACTTCCAATAAAATTCCTCTCATTAAATTACCCCTTTCTAATGACTTTGCTCTCAAAAATTTTTCATCGATTTTCAATTCTCAAAATTCTTGAATCTTCAGCGAAGCTGGAATTCAGCAATCAGAAGAGGGAAATATCTGTCAAGAACAAGGTGGCGGGTGACAGTAAAAAAAGCGCAACGCATGAAGGCAGACGCTAAAAATACAAAAGACGGTGAGGATGTTCAGATCGCAAGGCGTTAGGAGGGGGCTTGGTGAGAGTCAGAGGACGTATCGTCGCTCTTCAGGGGAAAAAAAAAAGGAAACGGCGAAATTCTTGATTTTGATTTGTTTTTTCAGAAAAAATTGGCCTCCGGAGGGTGCAACACCTGCCAAAAAGTGAACGGAAGATTAACCGCAAGACAGAGCTTCCGTTCGAGAGAAGTAGGATTTTGTCGATCACTCCAAACAAAAATTGTTTTTTTCAATTTCAGCAAAACTGGACGCTCCGACTGGAAAACGCGGCTGACGTGCACCACTGCCCAATACATCACAAAAAAGAAGGCAAAGAAGATGTACAAGAAGAGGACACACGACGCACGCGACAAATATCGAAAAATGGCGGCACTGGCCGGAGACGGTGAAGATGACGAGGAGAGTGAGGCCGAGGTGATGGAGCAGGATTTTGGATTTTTCCGCGGCATTTTTAAATTGTTTTTTTTCCTTTGTTGATTTTGTTACTGTTTTTCAGTTTCGACATAAAATAATCGAAAATTTATTTATCACAAAAACTTTTGCAATTTGCTTAGCTGAGTGAGCCAACTGTTTGCCACGTGTCACGATTCGATGCATCCATCCTTTGGGCGCCTCGAGCTCCGCTTTCGGAGCCTGTTGTAAGCTCCTTTAGAATTATTGTCCAGACCTTAGAAATGTTCATCGAGTACCGGAAACTTCGACGAACTTGCACTTGTGTACTTTCAAGCAGGCTCCTGCCGGATTAAAATCAATTTAAAAATCGATCATTTGAATTTCCACGTGGCGCGACGCGGCACGCGTTGCATTGTTTTTTCAAATTTGGTTGAAAAACATGGTGCATCGAAGAATTTTCTTTGACGATTTTATACGCAGAATCACATTTGACGAACAAAAATTCAAAATACTTTACTTTGCAAACGCGCTCCATTGATAAACTTATGAAAAATCGATAATGCTCAGATTTCACCAACGAGAATTTTCCTCCATTTGAAATTATAGTTAAACAAAATTAATATAACCAAACATTACGCAGTTCCGGTAAAAATTTCGATAGCTTTAATGCAAGTGCGCTCAATTCTGAACAAAACCCACCCATCCTTTCGACACCACCGTATTCCGACAATTTCAAATCGATTTTATTCGCAGGCCAATCAGTATAATATTGGCTCCGCGAGCAATTTTTCGATACAAAAGCCGACTGAGCAGGTCTGTGGCACACACGAATAATTCTCGACTTGTCAACGTTGACACTATTGCGTACATTGTCAGTGATGACGCGAATGGAGAATGCTGAAAAAAAACAAGAGTTTAAAGGGTGAGCTCTCGCACCACGATCCATGTTTTTTTGTGGGAATAGTGGAAATTTGGAGTTAGTGAAAAAATCAAATTTGTGCAATTTTTAATAAATTCGGCAAATGCGCTAGAACATCAGATTTCACGAGCAAATTTCATTTTGTGAGATTAAGATATGGGCATTTGAACTGATTTTTTAATGGTATACACACGAAAAAAAATACATAAAGTCGATTGCGAAAAATTTTAGGTTTCACCCTCGGCATTGAAAGCGCAGTAGTAGGAGTGGCGATAGGGCGCCCTGCTAAATTTTCTATTTTTATGGTGTTTCCTTTCGTTTTGTGCTAATGAAGAGTTAAGAATCTGACGCGACAAACGTAATCGTGTCAACGCTAAGACAAACGAATAATTGTATTTCTCAACGGTAAAAAGATTCACTCCTGCGCCAAGGTGCCAGCAAGTGCGCCCCAGCCCAATTCGACACTATGGGAATAAACTGTGGGTTTAAAAACTTAGAGAAGTCGTTTTTGTTCAAGATATCAGCCTAAGATATTAAACACAAGCGCGTGGTCGTCAAGGTGTCCCGTTAATTCGCTTTGATGTACCAAAAATGCGGGATTTTAGACGCAGACTTCTCAGCATTCGTATTGTTAAGAGTGTGGCTGACGTCCCAATCATTGCATTTTTCTGCAACAAATTCCCGCAATTTTTGTCGATCAAGCAACACCAAAATGGAACTGTTTGACAGCACGTGCACAAGCAGATCACAAGTGGGATTCTCTTCGAGTTATCCTCCCCAAATCCTGTCCAGTACAGCGACCTCCAACGTGGCTTGCAACATTTCCAACTCGATTTGCTCGTTATTCAACAGGAGATTCATTCGATGAAGTGTCATCTCCCTCATTTGACTCATTATTGTATTGGGTGACGAGCCGGGTGGAAAATTGGTTAATTGTTGACATGCTTTCTTCCCGCTACCTTGATCCATAGACACGTAGAACCACATGTTGCATTGGAACATTCGACGTTTCTTGGCGAATAGCAAGACTGGACACGTGCTCGGCGATCTCATTCTTAAAAGTTTTAAATTGTAACAAAAATTTGGTTCAAAATTTCAAAGGAAAATCAATAATAAAGCTACTCCAAAGTTTTCAGCCTGATGGGTTGGAGAGATGAGCAAGTCCTACAGCGCTTCAAGAATTCTAGGCCACGGTCAGAGTGGTGGCCGTGATCCTCGTACTTATTTCTTTTAGATTTTTTAAATGGGAAACTCGAATTTATGTGAAACACCTAGAACATTCCAAGAAAAATTCAAAAAAACTCTCTAAGGAGGACATCGATAACCCTCCCCCAATTCGAGATGTGACGTCATCAAGGGGAGCCCGTGACCTCGCTTCAAATTTCAATTTTTCAACGAAAAGTGTGAGATTAGATGTAAAATTACTAGGAAATTAGAAGAAAGAGTAGAAAAGAAATTTCGGGGGTGTCGCTCACCACCCCCACCCCCCATTTTTCTAGTGTGACATAGAAAGTGGATCGGCCCCGCTACCTTCCATTGGGTTCAAGTTAGTTTTTTTAATTTTCCGATGATTGTATTACTGTAGTCACTGTAATTATGCGAAACAACTGGTTGTCCAGTGGAGCACGTGTGCTTAATTGTCCGTCACAATTCCATTCTTAATTCCAAAACTTCGAAGACTTCCCTCCGGTTGCCGTTTATCGACGTGTCTTCGATGTTGTTTTGGTGCATATGTAGATTGGTATTCCTGGAATATTAAGGGGAAAATGGAGAAAAAATTCTGAATTGTACAGGTAATCGAGAAAAAAAGTTAAGACTCCATTTTTTTCAACTAAATTTTTTTTTCAAAATTTCAAAAAAAAAATTTTATTTGGAAGAACTTTTTTATAATGTTCAGGATTTTCTAAAATTACCTTTATCTCTCAAAACTTGCTCAACTGAGTTTTAGATTTCTGAAATTTTCCGCGTGAAGTACGAACACTCCCAATATATCGAAGGACAGGCGCATTTGCGAACTAATCTTATTTAAAAATTTCACAAATTTATTTTTTTTATTAACCTAATATTTCCGTTTATCGTATTTTCTAAATTAAATAAAAAAATTGTCCAGGAGGAGTACATGGCCAATTTATCCGAAGAGCTCATATGCACACTTCCTGTTCAAAAACAAAAAAAAAACTTATTCACCTTGGCGGTGGGTACCTCTTTTTTACACGACGAGGCGAGTTTTCCGAGCTGAAAAATGATCCTTTTGGCTGGGCAGTTTTAGAATTGTGGGGAAGTTATAGGCATTTCCGGTGAAAAAAATTGTTTTTTATTGGAATAGTTTTTAATATTCTAGGCCATGTCCTAAAGACTTGAGTCAAGATCTGAATTAAATTTTTGAGGTACGAGCTTCCAGTTCCCTCCACAATTCCCCCTATGGCCTAGAATTTCAGAAAGCTCTACCATCGATTCAAACTGTTACCCGTTACTTTTGCACAGGTTACGGGTTCCGGACGCCCAGCCAAACTTCCGCCCGTGGCCTTAAGAACTCCCAACTTGTTCCACCGACCTGGACGTGTTGCTCGTACTGGCAACTCATCAACATCTGGCAGTAATTCAACCGTTGGGGACACGGTACGCGGGGTCGACGGTAGACTTCGGCGACTGATCGGCGATGTAGGAGGACTTCAAAAATCAATCAATAAATCAACGACACTCTGCTCGTTTTGCAAGGATCCGCCCATCCGCTTGTTGTTTACCAATTTCTTTTACAACAATTCTAATGCGCAAAATTAATAGAACTACCTTACTTATAATTTTTTTTTAACTCAAAATTTTCAAAAAAACGACACTCCGCTTGTAGAATCCGCCCACTTTCCAAAAAACAATTCGGAGTGTCGTTTGAAAAATATCCTATAATTTGAAAAACTCATTAGTCTCAAATTTTAATGAAAATTACGTGAAAATCTATAAAAACTACGCTTTTGGCTCCGCCCAAAAACGTCTTTTGGCACCGCCCGAAAACGGGACGGAGCCTAGCACTAATATTACAAGATGGTTTTTATTTCCATAAGTGATTAAAAAATCAACAAAATATTTAGAAAGTATCTCAATTATTGAATTAAATTTTATAAAATCTACGACACTCCGCTTGGAACCCCCTCCCCTGGGCTGCCAAGAATGGGGCGGAGCCTAGAACAAACGTTTTTACAAGAAAAATGTTTCTTGAAATTTTAAAGACGATTAATAAAAATCCGAGTTTTTAGAAAAAATTGGGCCAAATCGAATAATAAAAAACGTTACTCCGCTAATAAAACCAGCTCATTAACAAGATAGGGGCGGAGAGTATCCAAACGGAGCGTAGTTTGAAAAAATATTTTTTGGAAAACTAAAATGTTCCAGCGGGAAAGATTCTGCTAAAGGCAATCTAATCCAGGTTTTTTCCGGAAATTCAATTTCCTCAGGGTTCTCTCTGCAAATTTGTTCACGAAAAAACTCGTGTGTGCTGGAAATGCGCTCTATTGCTAATTTCATCCAGAGAGCGCTATTACATCAAAAATGGAGGGTTGTTGCATACCTTCTCGTTGCAGCGGGACTGGTGACGGAGGTGATAGCCGTGATGAAAATTGTTGGGGTATCGACAGCGCAGAAGGGAAACACGACGATTCGACATTTTTCTAAAAATCCATGATAAAACTTGTAAAGATAAAATAATGTAAAAGGGGAGGTGGCTAAGCGGGGACACAAATACGCGGGAAGTCCGCTTATTTTTGCTGGATTTGACGTAAAAACGAATCAAAAAACTGGCACTCGTCGCGTTTTGCAACAAGAAAAAACTAAAATTTCATATATTGGTGGCAAACACAGTTCGAAAACTGTTGAAGCTTACGTAAAGTGTGTATATTCCATATTAGAGAATAAGATTGGAAATGGAAAAATAAAATCTTGTAATTTCTACCACCGCATAACTTCTAAGTCACCTATGAAATATCTAAGCTACCGTGAAAATTCTAGGCTATCATAAAAATAAAATTTATATATGTTTGTCCTGAAACGAAGTCCACTTCCGCCAGAAATAATAAACAAAATAGACAACACAAAAAATTGAGAACTCTTAAGAACAAAAGAAATCCGACCCGAAATCGAATACCCAACGAAAATTTTCGGAATTTAGAAAGAAGAACTATGAGTTTTGGACACTTTTCACTTTCCCTTCAAAAGGAGGAACTTTGTGGCGCGGCCTAAAAAATATAAAACTCGGCCACCGATTTGTATGCGGCCACGGGACACTCCGCAGTTGCAAAGGGTAACTACAGCTGCAAATACTGTAAAACTAGGTCACCAAGTGGAAACCTTGGTCATCACGTGGAAAAAAACCTATTTGACAAAAAATTTTTGAAAATTTTATAAATCTTAATTCTAGGCCACCACCTGTCCAGGTCACCATGTGGAAGGCTAGATCAGCTAAGTGGATCGTAGACCAGCACATAGGCCTCTAGGCCACCACGCAGGAAATTAGGTCACTGGAAAGCTAGCGAGCCTCCACATGGTCAATAATAAGTCATTGTTAGTTGGAATTTCGTTTTGACCAGAGAAACTTGTTTTTACCAAAATATTTGAAAATTCAAGGCCGTCCGGTGAAATCTGTTTAACCCTAGGCCACCTAATTTCGAGAAAGTCAGGACATCTAAACTGGCACGTCACAACTAGAAAGCTAGGCCATCAAGCAAAAACCTAGAGCCCACTCTGCCAAAATAGATTCCTTAAAAGTTTGAGGGAAAAAATGTTTTTCAACAAAAATTTAATCGGCCGAGTGGACTTTAATAAATTCTACTTTTTCAGCCACATTGTGTGGCAGAGGGATATCGGAGCATCGTTTGAATTTTCTAATTTCTGAAAGAAAACCGGAACACATTGCAAGAATACGAAAAATATAACTGAAGCCGACATATGAAATGAGTTCTATGCTCCCCGCCGCGTATTCTTCTCATTTTTCTGCATATTTTTAGCTTGGCGGTGGGGTGCGAATGCTGGTATCATACTTCGTCCCCTCTTCATTCATTGCCCGTCTATGTATTAAAATTAGCGTGTATTCCTATTGGATTCTGACGGTCTCCCCGTCGTTTTTTTTTCTATGCGAAATAGAAAATACGTGGTGAACGGGAATTTTCATGAAAAAGAACGAAGAATTTGATTTCTAGGCCAACCAAAAAACATAGGCCAGAAAACGGATCTCTAGTAAAAACAACCACAATAAAGTTGAAACTAGGCCACCTACGAAAAATGGGAGATACCGCTTGTGTGTACAAGCATTTTTATAAAATTCTAGATTGTTTTAAAAACTTAATGTTTCCAGTACAAATCGATTTCCGTGAAAAACAATAAATATGTCAAACTCGTGACGTTTCGACCGTCAATAGAGCGCGTTTGCTTGTCAAACCAAACATATTCGGTGTAGATTTACGGGGTTTTCAGACAAAACAAAAAACCTTCACAAGGATCCGCGCCAAATAAGAGCTAGTAAATGGAACTAATTCCCGTTTTTTTTTTGTTGGTGAGTGTCTTGTGAGGAGGGGACCGCCCGTGTCTCTACCTAAAACATTGTTAAATTAGTGTGACGTCACCACAATTTGATAAACGACAAATATAGTTCGAGTTTTGAAGAAAAATTTTGGAATTTTTCTGGTAATAATTTGAAAAATTTCAATTTTTTATGTTTTTATCTTAAAAAATTTTTTGATATATTTTTAAATTCAATGTTTGATCGTCCTGATAACCAAATTTTCACACAAAAAATCTGGTTTTTGACGTCTAAATCTGCTTTTTTTCACCCAATTACGAGGTTCTCCGTGGGAAGGTGTGTCACTTGAGCTTTTGCTTTTTTATTTTTTTTCTGATTGAAAATGATTAAGCTAGATATACTTTCTCGTCTTTTATTAATCAGAATTGTATTGTTATTGAAGATTTTAGATTTTTACACTCCCGTGCAGCAAATGCGCTCCGATGTATGGAAATTTACAACTGGAGATTTTCAAAATGTTCATTTATAGGCTCTTTTAAAGGTTCAAGAGTCTAGTAAACTAGGAAAAGGTGAAGCTGTGACGTTATCGATGACGTCATCACAATTGTCGCTTGAAAAACTTGGAAAAACGATGTGGAAAGAGGGTGATTATTTGTGCTTCAAATAAACTTTTTGCTCTAATTAATTCATATAGTTGTGTGCTTCTTTAGATTTTAAGAGAAATTGCGAATTTTGCACCCAAAAAGCGTACTAGGCCGAGTAAGTTATGGGAAAACTCTTCCACATACCGGACACAAGACGTGGAAAACTAAAAGTTTCTGTAGTTTTTTATACCCCCGCATGGCACATCCCCGCCCCAACACTGTAAATTTTCAGGTGTTCAGGGTGAAAACATTCTTTCAGCTGCTGGGCGGCTTCTCGTGCAGCTGGAAATGTATTTCCAGACGGGTTGGAACCGGGATTTGTCATTCAACTGTTGCAATTACGCTCTACCGAGCTAAACCTCGTTAGGACTCCAGTGGACAACACGGGCCTTATTGTAAATTTCGCTTCAATGTCCACAATTTCAGAACAAACCGTCGCTTTTATTCCATAATATTATAATTTTATTTAAAGAAATCTGGAAACATTTATCGCTTTTTGTGAAAATCTATGTGAGATTATTGCCAGAAATACAAGAAAATCGATGCAAACTTGCTCTATTGCTAAATAGTTCGTGTACTATACGTCGACGACACGATTTCAAGTTTCGTTTTTTGAACAAATAAGCGTCTGTTATTATTCCAAAATTCGGTACATTCACTCAAAAAAAAACAATCATTGATAAATGTAGAAACATACATGCAACCACGGCCTCTCCGATGCAAATTTTTGATTCTCCAACTTTTGTTGTTAAGTTATCTTGAAAAAAAAAATGATACAACGAGAAGTCCTTGGTGGTATCGGGCGCCTAGAAACAGATGAAATGGAAAAACAAGTATTACGGGCGGCTCCGTCTAGGCGTATTATGGGGGGTGGGCCGCAGATGTTCCTTTAGAATAAGAAAAATGTCTAGTATTTTGTGATACTTGTGAAACATAACCCTAAACTTCACAAAAAATAAAGGGCTCAAAAATGGTATTTTACTAATGTAAGCCTACAAGCACAAAGGAAATCAATTTTTTCAATAGCTAAAAAATTAATTTTTGTGATATATAATACTTACACAAGTACCAATTTAGTTTTAAACGATAAAATATACCATAACTTTTGGGTAGGATCTGCACAGCCTCGAAAAAAACGGGATTTTCAACAAACGGAATAGTCGGACTTTTTAAAAACAACGAAAAAGTTTTGCTTGGGACCAAGTCTCATCGATTACAAAAACTGATTCTTCCAGTCAAAGATTTTATATACTCACGACTTAACAATTCTTTCGTGTTGCCTACCTAGCAAGTTCCGAATTCAGAAAAGTTGAATTTCCCTCCAACAATTTTTTACTATCATAGTCAGCCAATTTGCAATATTTCCCGCGACAAAATTTACGGATTCCCCACAATGGGTCTCCAACCAATAAAATGAATTATTCATTTATCTTCTTAGGTCACACGAGATGCCAGCGACCAAGACAGGGCAAGTGCGACCACTATCCCGAAAAAGACACCTACAGAACCTAACGAAGGCTTCCAAAATTAGCATAGAAAGAGACATTAGCAGAATATCCCACTTGATGTTCTGTCACTTTCAGCATCATTCTGCCTTTTTGTTCCCTTGTGTATGGTGACTATAATTTGATTGTGCTGAATATGATGTCTACTTGTGTTGTGGACAACTATTGATTTTTTCTGCTTTGGTTAATTTGAGGTATTACTTTTACAAATTTGTATATCATCATTTTACAAATTTCAACAGTGTTTCCTATTAATCCGCTAAACCGCAACTGAAGAATAATAAAAACTTTTCTCAAAACTGTATGGGAAAGCTCAGTGTCGGTTATGATAGTATTACAACATCGTTAATGCAAATTAGGTTTCGCAAAATTATATTCAAAAGATTTTTTAAATCGTTTATTACGGTACCAAGTAAAGTTGAGAATGCGTATTACGAGAACATATTTGACGGGCAATATCTCAGAGCAAAAACTACAGTAACTCTTAGAATGAATTCTGTAGCGTTTGTATCGATTTACGGGCTCGATTTTCGAAATAATTTATATTTGTAAAGTGAAAGCTATATTCAATTTTTCTTCGATTATTTGTTGTTTTGTTTTTGATTGTGTTTTTCTTTTATTTTAATAGTATTTGTCACTTTTCAAATAGAAATTGATAAAATGGAGCCCGTAAATGGACACATATCCAGTAGAGTCATTCAAAGAGTTACTGTAGTTTTCGCGTCATCTGAGATATTTTGCCCGTCAGATATGTTGTGCAATACAATGCGCATTCTCAACATTCCTGTTACCGTGAAAAACGAAATTTTTTGTTAAAACTATTTTTGTAAGTCGAACAAAATTCACAACTCGATAAAACTGTCCTAGTCATCAGATTAATATAATTGAAATAAATAATATGAATTAAATTAAATTTTAAATATTAAAAATGTTATTGTTGTTTTAACAAAACGTTATTGGACTTTTCAGCAAAAAAATGAAAATAAAAATCGATTATTTTTTGAATTGTTGATTTTTCGGTTTTTAAATGTTGTTGAAAAGAAACGAATTGTATATACGTCAATTAAAAAGGCCGTTTAAATTGTTTTTTAAAATGTTTTATTTTTTTCAGATAGATCAACAGGAGTGAACTTCATATACTTCAAAAAGCCAGTATGGGATGTATCTATCCAACCACTCTATCAGCCACTACTCTTAGCACTAATCACAATGTACGACCCCGTGAGAGATTGTTGTCTGTTTTTTACTAGATATCTACACGAGTGGTAGAATATAAAGAAGAGTGGTGACAAGTTTGGGATCTGAGTCCCGTAGAAAAAATCATCCCACCGAAACTCTAAACTATGAGGGACTGGTCAACTATGCATTTGACGACGTCTACCTGTTTTAAGTTATTGATGTGGTGAAGAGTGATTTGCCTTTTGAAGAAGTCGCTCGACCTCGACCTTCTTCGACCTGATTGAACTGAAAGATCCTCGGGAATCATTTTTAGAATTTAGAAGACTGTACCGACTGTGGATCTTTTTGTTTGCTCGAGACGATAGAATACAGCCCCATCCGAACAGGGGTGCGCGGCAATTGCCGTGTGGCAATAGAATATTTCGGCAATTTCGGCAATTGCGGCAACTTAGGCAATTGCCAAAATCGGAAAATTCAGAGAACCGGCAATTGCCGAAATTGCCGACTGCCGGAAATCCGAATTGGAAATATAAACTTGCTTTTTTTTTGTAGTTTTAAGAGATTGAACATGCATTTTACTAAACAATTTTCTCTTTTTAAAAATGGTATTTAATTCCTTTGAAGATTGACCGTTTTCTTTTAGAAAACTCTGACTGACAGAATATCACAAAACAATGTGACATTTTTCAATTTTCGATATACATTTTTGAAAATTGCCAACTGCCCTGCAATCGGTCGGCGATTTCGGCACTTGCCGAAATTGCCGATTGCCGGAAATTTTGAAAACCCGCAATTGCCGAAATTGCCGTGCACCCCTGATACCGAATGTATCTTAAAAAATTAATTTTTTTGTTAATTTTTTGAAAATTTTCATAAAAGTAAAGAAAGGGCCAAATTATGTTTCTTGAACTACTCGTAGTCTGTGACTTCATTTTCGGCCTTTTTCCGTTTTTCAGCAATAATGATTGGTTTTCTTTGCTCTCTAATTTTAAACATATTTCTTCACAAATGTCTCAAAATAACTTCAGTTCAAAGTAATAAAAATAAAATAAAGAGAAAAACATAAAGAAAAACCAGTGAGTTTTTTCAAAAATAATTCAAAAATAATTCGGTCCTTATTTTTTTTTTTTTGCAAAAAAAAACAAAACAAACTGCCCTATAAAAATTTTCCAAAAAAAAATTGGAAGGTTATTTTAATTTCAGCGGTCTATTTTTGGAAGTTGTCGAACTAATCGATCAAAACATTTTTTCATTTGTTTAAGTGTTATTATGCTTGAGATATTCAAATTCCAACATACCAGGCGTGATTCAAAATCATCGCTTTTTGGACATAAAACCGTAAAACCCAAAATTTATGAAAAGTTTTATTATGATAGAGTCATTCAATAATATTCCTAGTACTTTCACTAAATAATCAAACAATTTTTGTTGAATGGCTAGTTTCAAAATCGGCGGCTTACATAAAACATGCACAACAATAAGAAAAATAGGTATGACTTCGATCTTCAAAAATATTAAAAACAATATTTTTAATTTTACAGTGTTAGCAGTTCGACGAATCAATGCAGCTGAAGTACACTTATACAATCAAATCACGCTTTTTATATTAATTTTTAAATCAATTGAACCCATAAAAATTACAATTCCTCAAACCACGTTGATCCTAAACGACTGCATTAAGAAAAGGGAAAACATAGGGCTTCCCAAAATGACTGCCTCCCGCCTTGTGGCGACATGCTCCTGCCTCGTCCAGGCCGCCTCTCCAGTCAGTGCAGTGCAGAAATTTTTCAAAATCAAAAACATGGAAAATTAGAGAAGGATTTTAGGCCTCGGAAATCAATTTTAAGTCCTCTAGCTACAAAATGAACCGTTTTAGAGGAGTTTCAAAATTGTGAATTTTTAACAATTACCCAATTTTGCCACTTTTGAATAGGTTTTTGATGGTTAAACCTAGATCTTCTGGATAATTCCGCATATATGAATTACCGTATTTCCTAGATTAGTTTTGCATACAAGACTAATTTTCAATTGGTCTGTAGGGGTACAAGACTAATAGAGACTGCACATTTAGACTATTAGAGGCTAACTGCAAGACTAATTTTTGAATGCTATAGAGCAACGTGACCAATTTTTGATTGTAAACTCACCTTGATATCGTTTAAACAAAAATACATCCTATTGCAATATTTAATCAATTATTTGAACGCTTTTAATCAAAAACTCGAGTTCAATTTGCCCAAAATGGGTCCAATTTATTAACGTTGCAGCGATCTATGCAAGATATTGCTGGACTGGAAAAAATGGTCGGGTGCAAGACTTTTAGAGACTGCAATACTAATAGAGGCTGCAAGACTAATTTTCGATTTGCCCGTAGGGGTACAAGGGCCCATAATAGGGATGGAATACTATTAGAGGAAATACGTTACCTGTTTTTGACATAATTAGACAACATTTTATTTTTGATAAATTTTTTAGGGCTCCATCATTACTTCCTTTTTTTTTGGACAATAAAAATAAATTTTCTGCTTAAAAGCGTTTGAAACCACTATATTTTGCAAAAGGACAATTTTTTAGGATTGGAGATCAATTTTATGTCCTCTAGCTACAAAATTAACAATTTAGCGGAGGAGTTTCAAAATTGTGAGTTTTTACAAAAAATTGCCCAATTTCGCCACGTTTTTTATTTTGGTGGGTTATAGATTTTTTAAATTCAGCATATATGAATTACCCGTTTTCAACCTTAAAGTTAGACCATTCCTTGATTTTTGCCCAATCTTTTTTTCAGCCATCTTATGGCTGTTCTTTTTTTGGGCAAAAAAAGTACAATAAATTTTTCAGCAAACGTACAAAACCATTAGAAATTGAAAAAAAGCAATTTTTTAGGGTTCCCCGATATCAATTTTGGGTCCTCTAACTTCAAAAATGATATTTTCCAATAGAAGAGTTTCAAAATTGTTTTTGTGCCATAAATTGCACCCCATTGTTGCCACTTTTAATGGCCACTTTTTGGTGAGGCATTCCTAGATTTCCTGAATTCTGCATATATGAATTACCGTGTGTATTTCGACAAATTAAGACAACTTTTTAATTTAAAAAATTAAAAAGGATTAAAGGACGATCCGTTCTTCAATGCTATGCACTGCGGATCTGGGATTCAGGTACACTGCCTGGTGGTGATCCCTCTGGGCTGTAATTTAAGCCACGTTCTCCTATCCGCGGACTGTGGCCGATAATCTAGTCGTGGATTGGTCCACTTCCCAATAGAGGCCGTTAGGGTGAACCTAGGGAGTGAGGCCGGACTTTTATCTCGTGGCCCCCAGAATGCTTGCGGCCACCACTACCCTGAACTGCTATCTGCCGCCCTTGGGGAAATAATTTTTTTTTTTTTTGGGCAAATAAATAATTTTTTTATTGGAAATGGTACAATTTAAACCAACTACTATATATTAAAAAATATTATCCAATTATTCCAAAAATTCCAAATAATCCAAATATTCCAAATTCCAAATATTCCAACTGAATATTCCAAATTTATTCCAAATAATTTTATGAAAAAGGCCCTTTTGTTAGGGCTGGGAAGTTTGAATTTGGTTACAACTATTGCCCAATTTTGCCGCTTTTTAAACTGTGGTTTTTGATAGGTTAAACCTAGATTTTCTCCTGGGAATTCTGCATGTATAACTTACTTGTTTTCAACTATCTAAACTAGTTCAGACTACATTATTTTTGTTTTTTCAAATTTTTTCAGCCAAATTAAGGACTTTTTTGGGCAACTCTTTTTTTTTTTGACGGGGATCAAAAAAAAATTAAATTAAATTGCCCAAGCTTTTTAACAATAGTTTTTGGTCCCGGAAACCTAGCCTAGTGTGGCCCGGAAAATCGAAAAATCGAAAACGATAATTTTTTGAAAATTTTTAAAATGAAAAAAAACAGACTCAATTTTCTTCCAAAATAAAAAAGTGGGAAACATTTTGAATATCTTTCGAATAAAAAACATAACTTTTCAAAAAATTTTGATTTTCCCACAAAAAAGTGAAATAAGAAGCAGGTTACTGTAGCTGGGATAAAGCTTCAAAGGGTGCGTACCAGGACCTGAATTAAACCGCCGCCCGAGTAAATTTCATCGACATATTTAATGTACCATCAATCACCTGATCCTCCTCTTCCTCCTTCTTTCAACCATTACACCACACAGAGTTCCTTTTATGAAGGTCTCAATTCCCCTTCATAACATTCTTTGTAATTAATGCACCAACAAGCTATGCGAACAGCACTTAGACACCCCCCTCCTACACGCTCTTTGGAGCTCCCCCGTTCAACTCTAATGGACCTGGTAATCCCTTGCGCCGTGGGATTTTTCGGGTCTGGCCGTGTTTTTTATCCGATTTACTTCCCGGAATACCGGAAATGGCGATCGATATTGCAGACAAAGCAAACTTTTTATTTTCAAAAATCCGCCCACTTTTTTTAAAAGTGATTCAATCATTTTTTCTAAAGTTTTTTTTTTTGAAAGCCCGCGCTGGCTTCCCAAATATTTTGGAATGTAAGAGATTGCCGAGTTAGCATTTGGACTCGGCCACGGCCGGGGGCGATTCACGTCGGCTCGGTTTCTGTAGAAAACTAAATGTATTTGTCCGTATGGAGTACAAAAGCTTTGCCAGGCGTTATCCGGCAGGCGATAGAAGCCGCGACGCAACACGCAACTCGCCCTAAGTCTACCCCGGCCGTGGCTGAGTTATGCCTACTCGGCAAACTCTTGCATTTGAAAATAGGAGCGAAGCCGAAGCAGGTGAACATGGCGATGTCTGGCTTCCCTCATAAATTGAAAAGGAATAGAGTTTACCGAACTAGGCCATTTTGGCTCTGGCCATATCTGGGGGAGATTTACTACCGGCGCGTTGCGTGCCCCGTCGCGAATCAGCTCGTTTTTAGTTGTAAAACTGAATGTATTTGTACGTGTGGAGCACACGACTTACCCACGCGTTGTCCGCTAAAATGTTAATGGAGCGCGAAAAATTCAATGAGGAAGGCCAAGAACCCCGTGTGTGATTTTTGCAACTACAGCCCAGAATTAGAACGGGATTAATACAAATTTAGTTTGAAATTCGGATTTCGCAATTGAAAATGTTGACCACGAAATTAAAATTTCGAAAACCCGAATCTCATCTAAATTAAATTCCAAAGTTTTCATTCAAATTTCAATGAGTTCTCTATTGAGCCGAGTTCCCGCGCACGGGAGGTAATGGACCCCTCTTGTAAGTTTAGGGGTACAACGACCCCCCACCACCCCATATGCACAATACAGAACTCTCAAGACCCGCCAACCCTAGGCCCCTCATCCAAAACATATCCGAATATACCCTCTACTGTACTTTATTTACTTGCTCCGTTTTCCCGGGTACCAGGGTACTCCCTAAACTAAGTGAATTTCAAAGGTGGTGGCCTAGAAAAAGCTCTTCCACTGGTTGTGGAAAGAAATGATGATTCGAGGTACTTGTTGATGCCTTTTATTGCTTATGGTAGGGTTTTTTTGCCACGTCGTGTCCGGGCAAATTTTTAAAACTATTTTTCTATTTTTTAAAGGCCCAAAACTTTGTTTTTTTTAATGGTATCGTTTTTTCGAGAAAAAAATTACACAAAACGGGGGTTTTAGGTTTAGGCTAAGGCGTAGGCTTAGGTTTAGGCCTAGGCTTAGGCTTAGGATAAGGCTTAGGCCTAGGCGCAGGCTTAGGCATAGGCGTAGGCTATAGGTTTAGGCTAAAGCGTAGGCTTAGGTTTAGGCCTAGACTTAGGCGGCTAAGGCTTGGGCTTAGGCGTAGGCTTAGGCGTAGGCGTAGGCTTCGGCCTAGGTGTAGACTTCGGCTCAAACATAAGCTCAGGGGCTAAAAAAGGAGAAACGCCCACAAATTCAATCCTGAAAATTTTTTTAAATCTTAAAATAGTCAATTTTCAGTGGAAATCACAGTGAGCATTTTGAAAATCCAATAATTTTCAGTATTGCTATAAATATTTTCGTTCGGATTGGACAATGAAATAATCGGTGAACCAAAGCTACAATGCAATCCGGAAAGTATTACATTCTATTCTCCTTCAACACACGGAATCCGTGTATGTTAGTCTTGGGGTCTCGACACGAATTCTTCCCGCAAAATTAGTTTTCCGACATACTGAGTACCCCGCAAGTAGAGCGCTTATCAATAAATTATAAATAATCAATAGAGCGCACTTGCCCCAATTTCAAAATTTTCAGAGGACTTTTAACGTATATATGGCTTTTACAGAACACCCGGCTGTCGTCGGCAATTCCTCGCACCGAATCAGGCTGGAGGCTCATTTGGTAGGCTCGGTGATTGCGGGATGCGGCGATCCAATCAGGGGAGATTCGCCACATGGCGTCAATCAGCACTTCACTTTTAATATTGCGAACTTTCGAATCTGGCGAGAGGAACGTTCATTCAATATTCGATGCTTTTATGCACAGTGGATTGGCTGTTGTCAAAGCTGATCTGGATGTCAGGTAGGGAGGCAATCGATAAATTCCCCGAAAATTGATACATTTTCCAAAAATCAATAGATACCCAAAAAATCAAACAATTCCCAGGAAACTGGAAGAAAAATCTCAGAAAATCAATAATGTATTTGTTTTGCAGCGCAATGCCGGAAGAATCGTTCGAACGTGACAATCGTAGTATGCCCCAATGCACATATTCCCTTCGTGAAGGGACATTTGAGGGCCCAAAAGTGTCGAATACACGTGTGGGAATGACAATTGTTCATCCATGGGACTGTGATACATCGGGGAACTATGAAATACTGCTACGTGGAATGGACACCATACTCGATTCACGTGGTGTTATTATGAATCTTTTCCATTGCTTGATGAGAATGGGTAAGAGTAGGGAAGTATCGGCCGGCTACGAAAAGAAAAATATATCACTAGAGCAGGATTTCTAAGCATTTTTCTCAATAGAGCGCGCTTGGTCAAATCCCTTAAATAAAATTATGGTGCATCGAAACGGGTTTACGTACGCTTCTGATAGAGCTGTAGTACTCGAGGAAGCTGAAAAAAATAATGAAGAAAGTGAAAAAAAACAAAAGTGTGAATACAGTCGCAGCCTTCTCAGATAAATTTCAAAAAACTGTGGATGGTCGTAAATGGCGCGTGAAAAGTTTTTTGAAAATGGCCCTCGAGGACATTTCAAAAAAGAGCGATTTTCGCAAAGCCCCCTTCTTCGATGTTTGCTTTAGAAAAACAATGCAATTTTGTTTATTTCGCAACAAAATTTTTGAAAAATGAGTTAAATTTGCAACTGCTAAGAGCGCGATTGCACACACACAGACACACCCATCAAACGTCAGAGACCCCACTGATTTTGTAGATTAAGGTTGAGAGAGAACATGGAAAACGTCACGAACTTTGTTCCGTCAATTCCCGTTGGGTTGGCGCTTGATCATCAGAATGCAATGAAAGTCTAAAATTAAGCCGTTTCGCTAAAACGTAGCGAATCTCATTCCACCGAGTCTATTTTCGTGAGGCGGGTCTCCAATTTTTCAAGTCTTTGCTCGTTATGGTGCATCGAAGGGTAATTCAAAATTTCACATAATTGTTAGACACTTTCCGACCAGTTCCAAATTTTTTATGGTGCATCGAAAGAATTTTGCGTAATTTTGCAATAGAGCGCGGCCTATTACTACTCACCTCTAAATTTCTGCAAACTCTTCCAGAAGGTTTCCCGTGACTTCCCACAAGTGGTATACCTCCCATCACTGACGTCAGCCACATGGCAATCGAAGCCATCTCATTTCCTGACCAACCATCGATTTCTTTCTCGTGCCAAATTAAGTTGTCTGAGGGTTAGGGAAGTATGAGTTTCGGGGTATGAGTCCCCCCGCGTGTACCCCATTACACATGTCCCCATCACGGGACAAGTACCAATGCCACTTGATAATACAATTGGAAATACGTTAGGTGAGTTATTTACGGCCGAGAAAACCTGCAAGAATAAAAGTTCAGCCACCTTTTTGGCGGATTTTTGCGCAACTGTATGTCGCACAAGACTTTACGTCAGAAGCAGTGGGCGTGTCCGCCTGCAGGCCCCGATGTTTTAGATGTAAAAAATTAGATGTTTTAGATGTAAAAAATTGAAGTTTGACAAAAAAAAATTCGGCCACCGATTTTTTTTGCTTTCATGTTTTGTCCATGCATTTCCAATTTTTTTCGTGAAACGTTTTTGTCAGAATTGTGCCGGCGTGTCTTGTAAAGTCCCGCCCAATTTGTGGGCTTGTTTCGACCAAAAATACTGTTTTGTTTCACAAAAACAGAGCCAGATATAAGCATTTTGAAAAAAACATCCCTGTCCTCTCCTTTCTCCATTCTAAAATTTGAATTAGATCGTAAAAAACCCCCGGTCTTCAATTCCAGTGAAGAATTTGGCGGCAGAGCGTGTTTGCTTGTCACAGTTTTTTTGTCGACACTGAGCAAACTTCAACTCTGCTTCCAGCTAGAAATCCTTTACAAGCAAATTCAAATTTTCAGACGGAATCCCAAGCGACTGGAGCCGTGGATCAAAGAGCCCTGCTCCTCCCACTGATGACGTGGCAAACATCACCTCAGAAGGCAGAGTGCCTCGGCATCGTCATCACCGAAGAAGAACAAAATGACGAGTCGAACCATGTTGAGGCGCGAAAAAAATCGATTTGCTCATCGATTATTCAATATCACATCGGAAGATCTCTATGTGTCAGTGAGCCAACCGTCGAGCCAATGGAAGTAGAGATGCCTGGAGCACCGAGAGAAACTGGTCGGAGGGTGTCTGAGCCATGTGTCTCGGTTGAAACTTTCGATATTCGGCCCTTGCTGTACTTTTCGTTTTTGTCGTTTCGTTTGGACGGTCTGTTTCTTCGGAAGTCATATGCTTAAAAATTTTTTATTGATTTTTTTTCCTCCCACAGGGTTCTCACCTTCCTCATGCGGTTGATTTTTTTGCGCTCCATTGACACTCGCTTGTCGGAAAGAAGCACGCATGGGAAGGTTGTGTACACGGACAATGCGTATACATTTTACAATTTCTAAAATCGAGCCGCGCCGCAACACGCAACCCGCAAACCCAGCTAGCCGAGTCTAAATGGCCTAGTTCGGCAAGCTCTTTCAGTTCAATATGAGGGAAGCAAGAAATCCATTTGCCACCACAAGATTTTTGCGTGGCCGTCGCAGTTTTCTAGTTTCTCGGCCACGTTGTCAAAAATTATTTTAAATCGTACTGGGAAGACTAAATTAGATATCTCTCCTGCAGATTGTGATTCGCGGAAAAATTCCATGAATGTTTCTCCCAGTCATTTTTTTTTTGTAAATCCAACAAATCAAATGAGCGCCAAAACCTCACAAATCTCATACTCCAAAATTTGCGGAATTCCTCTTTATTTCTTAAGGCCTCCTCTTTGGAAAATTTAAAAAACTCGTATAAAAACTTTTTCTTCCGTTGCAGCATACGCACAGAAAGTCTTTAAAGTCTGAAAATAAAGTCCCAAAATCCCACTCTCATTCCACCGAGAGGTCATTTTCCGTGAGGTCTCTTTCTTGGGTCGCGACGCGAAAATACTGTAATTTTATTAATCTTTTCAGAACTCAAGACTGTGAAATGCCGATTCCAGCCAGAAGGATATTAGCTAAGCGAACAGTGAAACTCTTGTTTAAAAGTATTCTGTTTCCCATCCACGTGCCATAATTCTTGCATTTTTTTTTTCCCTATTTTGATTCAATTTATTTACAATTTGTTCAATTGCCTAAATAATCAGTAAATAATAATTTAACATTAACACAAGGCGTCACATTTTCGTATCACGCGTGGAATGTAACGGTGCCGTTAGTGTCAATGGTTCCGGCTGAAAATTAGTTATAATTGGAGCGCATTTGCATTTTTCTCGAAAAATAGATGTTTTCGTGTGATCCAGAATGATTTATCGATTTTTCTTAACTTAGTGGCCGAGAAAATGGAATCGAAACGGGCTCAGACCTCGACTTTTATTTACCTGGAACGAAAATTTAAAGTATGATCAACGCGCTAAAGCCTCAATTATGCAAAACGCTTTAAAAACGGGTTTTGGAATTTCCTCGAGACCACTGGTGACGTCACTCCTTTTCAATTTATTATTCTAACGTTGTTTTCTAGGCCACTGATGTCGATATTTTTCCACTGGTTTCTAGATCGCCTGCGATGTCATTTCTCTTCCATACCCTGCTCTAGCGGGTTTCTAGGCCGCTGAAGTAATTATTTTTCTTCCAAAAATAAATCTAGGCCATTAATGACGTTATCTCTAGTTCTTTTCCTTAGGATTCCCTCAGGTTCCTCATATTTCAGATCCATACTCGCCACGTTCATCTCATGAACTTTTTCCACGCTTTTTCACTGCTCGTACTCTTCTCATCTACTGTATCCGGCACCACAACGTCGGAGCAGCAGCTTGCTCATCAATATGCTGATGTCTCCTGGCGGACGTGGTGTATCTGGTGCAGTTTCATAGTGATTTTGCTGCTTCTCCATGAGATTCTGTATTAAACTGGCTGAGGGAGGATTACCACGAACGGTGGCATCGGAGGCGGCAGAGGAGCCATAGATACGGGAGTCTGAGAAGCCATCATGGAGTTGGGGGTAATTCCTTTGTTCGTTGGGAAATCTGTGGTGACATTTGTGGGGCCATAGGGGACGGGGACATTTGGAATACCATCGGAAGCATTGGCGGTGGTGGGGATGCCGGAGCCATTCGTATCATTGGAGCCATCACGTAAGATGGTGGAGATGGTGGGAGACTGGAAGGATTTTTTTTTTGAGTTTTTTTCGTAACACGGGCGTCTGTCCTTCCTCATTGCACTTTTCGCGCTCCGATGATAACTGCCGGACGACGCGTGGAAAAGTGGTGTACTCCCCACGGAATACAAATACATTTAGTTTTCAACTGAAAACCGAGCCGTGACACACGCTATCCATAAATGGTGTCCTAATTTCTGTTTTTTAATCTTGAGTTAAAAGTTTAATAATTATTTCTACAGAATGGCTGGGAATGTGACGACCCACGTGGAACCGAGAATTCTCCTGCGTGGACTCTTAGACAATTCAAAAAAATATTGGTGGTTTTGATAATAAAGGATTTATACGGATAAAAATCTATTATAAAAGCCGTGAAAAAATCATCATCAACCACTGCCTAAAAGATTGAAATTATGATGGCCGAGACTTCTCAAGTGTGGCCTAGGTAAAAAATCTTAAGGCCTTTGAAAATTTGCTCATTTCGAAAATTAAAAAAAACAACTCAATTGATAGGTTGTTTAAAATTAAAAATTAGTTGGTCTTTTTTTCTCAATTTATGCAAAATCAAAAATTATAATCAATTTTTAATCCAGAATTCGTCAAGTGGCCTAGAATTCGACTGCTCGGGTGGCCTAAAATTCCCCCAAAATTTAAAATTATTGATGCTGGCCAAAAAGTTGAATAGTGCCCGAGGTTGTTCGTATTTCACTTTTCTCAGGCGGCCTACGGAAAAAAACTCGGCCACCAATAGTTTTTCCTAGGCCTCAAATGCCCTAATTGTATGTTAATTACAGTATTTTCTAGACAAGATTTATTTCCTTAAAAAAACTCGCGAATAGCACATGGAGCTCTGACTCTTGCTCCCACCAATACAAAATTCCGAATTTTTTAGAAAAAACCGCAAAACTATAAGAATTTGTGGTAGAAATTGGGGCATTTACGTAATAACAATAATAATGTCCGCAAATTTTTTTTCATAAATTTCATAGTCCAGGACGAGGTAAGCCTAGAATCCATTCAATTTTATTGGGCCGCCGATCTTCGGAACACTTTTACAATTTATACAGTATACAACTTTTACCTGCAACTTAATAATATCATCAATACTTCCAGAATATTCTTCTTTTTCCTCTGGCTCAATTGCCACGTCATCATCTTGTAATCTGGTCCATTTTGCTGGCGAGGCGTCGGCAAACAGCATTTAGTATTTACGGAGCAAGATCTTTCAAGGCCCGCATGCGACAGGAACAATTACGCCAGTCTGTGAATCTGAAAAAAATAATCTTGTCTTTTAGGTGACCCTGCCTGCCAAAGTCTGCCTTGCAAGGGACCTTTGACCTACTTGACGTACCTTCAAGTGAGACCTATGCTGGTTTGCCTGCATTTGGGTTTTGTCAGTGCCTTCTAGGCCAATGCCTACCTTTCAAACTATGTAGGTCAACTGTTTTTAAGGTAGCCTGGGTCAGCGGTCACTATGCTATCTACGTCTACAATGCTACCCCGTGCCTATCTACCTGCTTTTAATGCTATCTGCCTTTTCAGCCTGATAGTTTAGGGACAATCTACGCCGGTCCAGCTCACATAGGTTATCTAAATGCCTATCGGGTTTCCTTCCTGCCTGGGCATCCAAAGTGACCTAGGCTTCGTGTTTTTTGTTCTAGATCTCACCGTATATACCTACTTACATGCCTGCCTTTAAGTTTACCTATGCCTGCCTGCATTCCTCGTGGTGCCATGAATGCCCTAAAAACTCACGTATCATAAGTAACAATCATATTGACGAACAACGGTTCGATGAGTTAATATCGTGCAAGCCCAGATCATGATCGGGTGAAGAGAAATCGTTGGCCTAAAAATTTACTCGGCCACCCCCTTACCTGCTGCATTGCGAAATAAGCGTACTGCTGGGAGTGCAACGTGGCACACTTATTGAATCCCGCCGTATTGCCCCATCACACTTTCGGCGAAAATTTGGAATGATGGAAGAGAATAGGATAACCAGGCCATGGATGTATGTGCGCTATGTTGATAATCGGTTATTTTCAACGTGGATTATCAATTGAGCGCAGTTGTCCCACTGGAAGAGTTTTCCTATCTAGGCCACCACCACCACCCACTCACCATTATAATAATAGCCAGCAAGTGTTGTTCATGTGGAATAAATGCTATAACGATGAAAAACACGGCGGCCACGGCCAGAGCTATTGTGTTGAAAATTTTAGTTTGCAGAGTTTCTGATGAACATCTGGAATATTGATTTTTGGTGGCCGTAGAGAGTAAAAACTCGGCGACTGAGTATTTTTCACATTTCAAGTATAAAATTATTCCAAGAAAAATCTGCTCCCGATAAACTCACTTAATATAATCACTAATAATTCCCGTAGCCATGAAAATTTCGTAAAAAATAGAAACATAATGGTAAGGCGGCCAAAAAACAGCACGAAAGTACGTCATAGTTCAAATAATTTTTCATATATTGCGGATTGAATTGGGATACCAATTGACCTGTTAAATCTCCAGACGTGCGATCCAACAAGGCCACAGGCTTAAACTTGTCAGAATATGACGGAAATACATGGAAGATTTTTCCTGGCCGGCATACCTGCCGAAAAAGTAACGGGCTGCGAATTTGCCCCCTCATGTTTTCAAATGGAAGAGGGTGGCCGTGAATAAAGGTAACCTCTACCGGACCTGGGTCGCGACTCGCGACAATCGGGAAAATTTTCTCAAAGAAATTTCGTACTCTCGCTACTTTTAGTTTTCCTGTTTATGGCATCCCCCGGGTCGAGGTACGCTTTTTTCACGGCCACCTCCTCTTTCCATAGTTTGAAAACATGGGAAATTCGAAGCCCGTGAAAAGTTAGGCCCAATGCGATGTGGTGGCCGAGGTTTTGAAAATTCGGTTACTCTCATGTAATAAATCTTGAAGTCGAAGCAAATTTGCGTACATCAAACCCATTTACCTCGTTAGCAGTTTTAGAAAAATTTGGGATTTTCTCATACTAATGAGGGAACGTCATAATTGTCGACACATTGCGTACCCCGAGGAACCAACTAATTCAGTCCTAGGTTTAGGCATATGGTAAGGCATAGGCTTAGGCGTAGACGCCTAGGCTTAGGCTTAGGCTTAGACGGGGTGTCAGAGTGCCTTATTTCGGCTTCATCTACGTACATCTACAAGAAGGGAGAAGAGACGCAGAGTTTTCTACTGATTTCGCAGACTTGGTTAAGAGTGTGCTGACGTCACATTTTTTGGGGCAAAAATTCCCGCATTTTTGATAGACCAAACCGTAATAGCACGGCCAGGCATGCGCTTAGCCTTGAGTCCGTAGTCCTTCGGGCGCGTTTTTCTCAAAAATGATACGTTACCATTTCAGGTTTTTCCGCTCCAAAATCTAGTTATAATAATTTGTGTGCCCGTGTAGAGCGCGTTTGCACTGACTTTCTTTCCCTCGATTTCCCTTATCGAATCCTCTCCAATTCCTTCTCGCAACCCCAACTGTGCTCACTCGGCGGTAAGGACTTGAAAAATCCCAGGAAAAAAAAAAGTGACCAACGATACCCCGGCGTTAGTAAACCGACGTCCATCCACCAGACGAAGAGCGTAATCCCGGAACTGTGTAAATATATTTGAAAGTTGATTTACGGTTAATAGTCCAATGAATACTTCGTGCTCGTATGGAGTCGCCCAATTATCCCTGCTGTAAGCCCATCGAGCCAGCGAGGGGATATGTGGCTGAAAATGCCATTCCTTGATAAATACGCGGCCACAAAATCCGAAGCCAATGGTACTTGCCAACGGGATAAGGGCTGTTGAATACTGGAAAAATTGCGTGCAATACATCATATTTGACGGGCAATTTTAGAAAATTTAAAAAAACGCGCTCTAATGATGCTTGGTGTACTCCTCTCGGACAATAAATGTCAATAATTTTCGAAAATTCGATAATTTTTGTTTAATTTCAGAAAAATGAAATCTGTTTTAGCATATTTTGAGCGCGTAAAATATGATTCTTAAATACTTAATTCAGTATTTTACGCAGGCGTGGTATCCGAGTGTCACCTCTCTAGGCTTGATCCTTGGTACGTAGATCTACAAAAAATGCGGGAGAAGAGCAGACGCAGAGTTCTCAACTGATTTCGTATGAGTTAAGCAAGTGCTGACGCATTCACATATTTTCGGCCAAATAATTCCCGCATTGTAGATTCAAACCGTTATGGGACAGCCTGACACCACGTGCTTACTCGGACTTTTTCACAATTTTGTGCTTCATGCACCATTTGTTTTTGTTTCGAAAAATCAGATTATTTAGCGGGCAAATGCAACGCCCACTGTGCAATACACCATATTTGACGATCAATTTCAAAAATTTTGTATGCTTTCGTGCTTTTCGGGGTACTGTAGCTTTGAAAATACGCATGCACTGGATCTGACGGCAAAATGCACAGTTTTTATAAAATTAGTCTAGACTAGAAATTAGTCAGTTTTCACGAAACAATGAATAAAAACTACAGAAAACTCGGCCACCGATATTTTTTTTTTTCGCGGCCACGATTGACGTCATACCTCATAATTCCGCCGACAAACCTCTGGAAACAGGATTATGCGGCAAATGTTGAAAAGAAATGGAAAAAATGGAATCGAGGCGGCAAGACTATAGCCACACACGATTGAAGAAAATTCGACTCTGATGGTTGGGATCGGAATTCACTGAAACAACTATTTTGGCTGGGCCGCCAGAGAAGACTCGGCCAACGAATTAAAAAAAAAACCTTTTGAAGTTGAAGTACTATTATCATCTTGCATACAAATTAAAATTATAAGTTCATATTTGAAAGAATCGAGGTCAAACACAGTGTGGCACATATTAAAATCTGCAAGAAAATCGTGAAAATTCAATTTTCCGGGTTTTGAGTTCAAAAACCAGAAATCGGACAGGAACCGGCGCGTTGACCATGGTGCATCAGCAACCGGAATTTTAAATAAGTAAAAAAATTTACGATGCTCTGATAACCAAAAGTGCAGTGATCCATTTAAGGGAAATACTGCTGGTGGATTAAACGTTGACACTGTTAACTTGATAGTTTTAATTTGATCAATGCTTGGTACTTGTTTTTTGCAGGAATCTTTGAAAATTGCCAAAACTATAATACAGTCTGAAAATTGATGATAATCTAAAACTTTAAATTCCGTTAATTATCATTATTTTTACGAAATTTTAATATAATCTCCTTAAAATTTAATTTTCTAGGCAGCGGTCTGTGAGCTTAAATTTTCGATTATCCCTCGCCAAATTAAAGAGCAGACTTTTAAGCTTATAAGCTTATTTCAGTGAGAGGAGAGCATTGTGCAAGAAGAGAAACGCAGACTAGGCTTGCGCGTTTCTCGTGCTCTGACGCGAGTCTCGATTTCCGTGGCTTGCGCATTTCTCGTGCGCGCGACGTTCATTTTTTTCCGATTTTTTTTCAGTTTTGCTGAACTTTTCTTTAATTCGTGATTTTTCATTTATTTTTCACCTCTTGTTGCTCGAAAATAAAACTGATTTTTCACACAAAATATTCGACTTTTCAGGTTCCGGCAACATGGGAGTCTTGTACTGAAAAACTCGGAATTAAGCAAAGTGGGACTCGTCGCCGGCGCAGGGCGTCAAACTGTCAATCGATAACGATATTTGGTCGACTAACAATGTTAAAGTATTAGTTTGTTTCCGTTTTTCCACGAAAATTTTCATTGTCAGGGCAGCGAACTGTATCAAAAGCTTCAAAAGTATTCCCGGCACCGTCGTCTTTCCGGAGCAGCTTTTATCGATTTTTTGTCTGAAAATGCAATTTTTTTCTAATTTTCAGCTCCCTGAAACACTCGAAGATGTGCAGCTGAAGGCCGGTGGAAAGTGGAAAAGTGCTGTTGACTCGGTAGGCTGCATTTTTGATACAAGAGGAAACGGAAAAATTTGCGAAAGGTGGAAAAAAGTCCTAAAATGGAGATTTGGCGCCGAACGTCATTCAAGAAATTCCATAACTTTCAAAAATCTATCTGAAAAATTGAAAAATATAAGACCATTTTCAGTCATTTTTAGTAAGTTTCAGCTAAACGTCGAAGAAAGTGCCTAAAACTAGGAAAAATATGAGAAAAAGACACAAATTTTGGAGAAAATTCCTGAAAAATGCAAAACACTTTTTTTCAAAAGCAAGTAATTTCAAAAAAAATCCCAAAAATTAATGCAAGTACGCTCCATCGCCCTTTTTTCCAATTTCTGACTCGAAAAGTCAAACTTCTGGTTTTGTAGGAAAGGTTATGCAAAACGCAATTTTTAGTCCAAAATTCCGAGAAAATTCTGAAATTTAAAAAAAAAATGCAAGCACACTCCATGGCACTCCGTTTCCTTTGCAAAATTTCGCGTAGATAAATTACAGACATTAGCAAAATTCCGACGATTTCGCTGACCATCACGGAAATATTGTAGGAAATTCAAACATTACACTTCCGAAAATAATTCCGCAAACGCGCTATCGCACTTTTCTCCAAGTCCCCACTCAAAAAGCATAGAACATACCTGAACTTGCCGTTTTTTTACACCAACTTCAAATTTACGCGATTTCGCTGCGAGACCCAAGCTAGTGCAGTTGCGCGCATTTCCAACAATTTCAAACTCAATTTTTTTCAAGTATTCACCACAATCGAGAACGTCCCATCAAGCGTGAACAGTGCAAGCCAGGATCGACTCATCAATAATAAATAAATTCCCCATAAAAATTATCGATTTATCGATTTTCTTTGACCCCCGAATCCTCTGTATTCCTTCGTTAGAATGTACTTTTTCCCTCCTCATTTTCTAGAAATATGTGTGTGGTGCAATTCTATGAAAAAATGCATTGCAATTTTTGACTTTAAACGAGACGTACGGTGCATTATTTTATTTTATGTACAGTTCCCGTCGTTGATCAAGTTACTCCACTGATATCAATTCACTGATAAGCCCACACTGACTGCCCAGCCCAACACAATTCCGCAACTTCTTCTCCCTGCTTTGCCATGAATTCGACGGTGGCTTCCCGTTTCTCATGGGGATTCATTCTGACCATGCGTCGATCGATTTTGTTGTCGTGTTGCCTACTGTTTGCCTGCCTGCATGATGGTTCAAATTGAATTTTACTCCGCAATTTGGCGTTTTTTTTTTAAGAGGTTCGATTGATTGGCCGAGTTAATTTTAGGGCACGAAAAATGAAAAATGAGCCGAGTGTCATTTTCGTTGGAATTCTAATTTTCAGTGTGTAAAAATATAGAAACCTCCAGCAAAAAATTTTGAACATCCCCGCCAAAACGTTACGAGACCCAAGTACAGCGAATGAGAGTTGCAAGAAAAAATTTTTAATGATTTGCAACTACGCTCCACAGTCCTTGGGTCTCACAACGTTGTAAAATTGTGGTATTTCTTCCATTACTTCTTATAATAACGATATTCGGTGGTCTCGACACTACACATTTTCATTAAAAATAAAACGGGCGCGATGTGCGCCTTTCAAGAGCTACATACTGCAGTTTCAAACTTTAGTGAAGTTGCTAAGCGTATTTTCAACAACGAATTTGAACTTACAGTACTCTTTAAGAGGCGCACGCCCGTTTTTATTAACAGAAACTTGTCGAGACCGGGCACCGTAGTTTTGACGCTAAAAATAAGATGTATGAAAAAGCGGGTTTTCAGAAAATTTCACTTATCAAAGATGAATTTGAAGTTTCCAGCCAAAATCGCTGCGAGACAGTGTAACGAGTGCAGAGCGCGAAATTGCTGTAAAATTTGATTGAAAAAGTTTAAAATTGAGATATTTAAAAACGGATTCTGGCGTCCCCCGTAATTGAATGAATTTCCCGAACTAGGCCACTTTGGCCGCGGCCATATGGGGTAGATTTACGGCGCGTTGTCGCGACCCGATTTTATGTTGGAAAACTAGGAATGTTTTTGCCCGTGTGGAGTACACGACTTTCCCACGTGTTGTCCTCTAGGTGATTGTCACTGCAGCGCAAGAAATCCAATGAGGAAGGCCAGAACCAAAAAGGACGCGTTTTTGAAGCAATTCATCGAAAGAAGACAGTAAAAAAAAAGTCAAAAATTCAAATATAGAAAAACCACCAAACCAACATCCAGCACAATCGACCTATTCTTGATGCTGCTATTTTTTTTGCACGTATGGATGTGCCGGCGGAAATCCACGTGGCCAAGAAGGCGGACACGTTTACAATGTGGGGTCGGTGGCCGACGCCGTGGCCTAGAAATCCAGCCGAAAAGTTTCCGTCAAATTTTCTGCCAATTTTCTGCTCGGCACTGCTCATCTGCGCGGCGAGCCCCACAAAATTCTTGCTCCTCCTCACAAGCTGAAGCCCGATGAGTTCCTCACTTTCGGCGACCCTGCCTTCCTTGTCTGGAATTTCGTTTCCGCGATCATTTTTAAGTCCTCGTGGACAAGATGCTTCTCGCGAACTCCGTCTTCATATATAATTTTGAGGATGAGGATGGAAGTGCCCTCCGCTGAGAGCCTAAAATGTAGTTTTTGATCACCCCCACGATTTTCAGCTCGAGGCGGCTCCAAAACAAACGTTTGAGCTTATTTTCCGCCTGCTCCAATACTACAAATGTGAATGGCTCTGGCATATTGTTTCTAAAGTCGTGGCTCTTTATTCATTCGATTAAGAGAATATCCATCGCGTCGGGGTTTTTTGTTTCGAATTTAAAAAAAAACACAAGTGGAAGAGTTTTTAAGATTTCTTGGCCACGCACACTCCAAAACCCGAAGTTTCAGCCCGTATCTTCGTTGTCCCTATTACACGGGACAAGTCATCGCTACCGTGGTCGCCACAAAATCGTACCCAGCCCTCTCCAACGCTGTCTACATCATGACAATCATCTCCTTGGTGAGCGCTGTCGCCGCCGGATTCCGAGGAGGATCCTTCGAATACGCCTCGCATACAGGATCCAGACGGCAATCCGCTATGATTTGACGGACTCGTGAAACAGGATCGCTTTCTATGATGCTCACAAGACCGGAGTGACTTCTCGTCTGTCTGCTGATTGTCAGACTGTGTCGGATACAGTTGCGTTGAATGTTCAAGGTTTCCTCAGGTAGGTGTGGGTGCGTGACCGAAGTTCCCAGATCACACCTAATTTTCCCAAATTCTTCCAGAAACTGCGTTATGCTCCTTGGATCGATGAATAAGCTTTCCGCCTCTCCCTCTTCACATTCATCCTCGTCATTATCTTCGTCGCCTCCAAAAGCTTCGGAACATATTTGTCATGTAAGTGCGCTCCAGCGAAAATGTTTTTCTAAAGTTTTGAACGGACCCCAAAATTCTGTCAAAGTGCCCCATTTTGGTTTTTGATCTTCGGAAAATGCCGGAGATAAGAGGCGCAGGCTTTGCAACTGATATCACATGGTAAAGATTGTGCTGACGGCACATGTGACGGAAAAATTCCCACATTTTTTTGTAGCTCAACGCACCTGACACCACGTGAAATTTTTGACAAGTCAAGAAAAATTTCGGCAAATGTGAATTAATTACCGCCGCACGTCGTGCCAGGCTGTCCCATTACGGCTTGATCTACACAAAGTGCGGGATGACTTCTTTTTGCCCAACGCGAATTTGACGTGAGCACTAATCGTTCTTAGTCATGCGCTAAATTAGTAGATAACTCTGAGTCTCTTCTCCCTCATTTCTTGTTGTTCTACGAGATCAAGTCTAAATTACCCAGCGTCTCTGTCACGTGCACGCCTCCCACCCTCCGACGAGCAATCAGCGGATTTACTTACTCAACTTGTTTTATTTCAGCTCCTCTCCGAAAGAACACAGGACAGAATTGCCGCCAATGTGCCGAGGAAGTTCTCTCCACAATGCGTACAGTCCGATCCTTTTCCTGCGAGAACGTCGACCGATCTTCTACGGGGAAGCTCACCCACACACTTGATGTTTGGCCACCAGAACCAAGCTAGCGATCGCCTATATCGGATTCCTCTGCTGGGCTTTTCCAGTTGTTCATTATTGTGTCAGTCCTCTGGTATGGAGGCCATCTAGTGCTGCACCAACGCAGAAAAAGAAGGGAGATCTTCTAGTGTCATTTTTGCTCTATCTCAAAATGCAACTCCGAGATAATCTTCGTCAAATGGTAGAAGTCAGGAGGCCACAGGATTGATGCAATCTGTTGGAGCAAGTCGTGAAGTGTTCGAGAACATTGATCGAGAGCAAATTCAGCACAACGGAGAGCATATGCGGAGAATGTTGTTGGAAAGATCGAGTTCAGAAATGCTCGCTTCAGTTATCCAACTCTCCGGTCCGATCAGCCAATCCTTAAGGAACTCTCGTTTACCGTTGAACCAGGAGAGACTGTTGCATTGGTACCAGCCACCCTGGCTGGAAAGTCTTCGTGCATTTCTCCGTTGCTTGAGAACTTCTACGTCCCGAATGCTGGACTTGTGGATGGAGTTCCGCGTTGCAAGAGTTCGAGCATCATTATATTAATAAGAAGGTACGTTGGCGTCAATTTCGGTTCGACAAATCGTTTGCCGGTTTGCCGTCAATTTTAATTTTTGGCATATTGCCAGATTTGCCGGAAGAGTTTAGAGTGCTTTTTTATAAGACGGAAACACTTGAAACTGTGTCCGTTTTTTTTTGTGCCGGTTGGCGATTTGCAAGATATTTTCACCGGCAATGTGCCTTGCCGATTTGCCGGAAATTTTCCATTATGGCAAGCTGACACCGATATGCCGGAAATTTTGATTTCGAAAAATTGCCGAGAGGCCGGAAGTTTCAAGGCAACTCGCCGATTTGCGAAATTTCAATTCCGGTAATTTGCCGATTGGCAGGAACAAATCGTTTGCTCGCAGTCTATTCGGATAAAAATTGCGCCAACTGGTCATCCGTTTGCACAGAAAAAGCATCTCCGCGCTTCGCTATTGGCCAATTTCATAGGGCAAATGTGACGCAACAAATCACGGGTGTTTCTTGCTTTCCATTGCTGAAACTGTGACTGGTTGGGCCCAATTTTTTGAACTTGACCTAATTGCGAAGCGAAGACTCTGGACGCAAGAAACGATTAGCTCCGTTTTCTCCTTTAGATCGTCTGTCGATCGAGATTCTCTGCTTTAAAAACACATTGCCCATCTTTTCAAAGCCCCTGTTTCAGCAGCTAGTAACAACAAAAAACCTCGAAAACTTCCAATTTTTCAGTTAGCCTTTGTCGGCCAGGAGCCCGTCCTGTTCGCTCGTTCTGTTAGATAAAATGTCAGAAGTCTTACGTACTGTGTCGAAGTGGCGGACGGTAAGCACGATTAAATGCACCATGAGCCGACCAAAAAAACTTGTTCAGGAAATCATTCGCGTGAATGGCGAATGCTCACGGATTCACTAGAAAACGTTGCAATACGAAACGTCGGAGAGAAGGGAACACAAACGTCCAGTGGTCAGAAGCAACGTGCAATTGCTCGGGCTTGTTCGTGAGAGCGTTTCTCTTGTTCCGTGGATGAAGCCACGTCGGCTTTGGACACTGAGTCCGAACATCTTGTTCAGAAACTTGACCATATAAGAATTTGGATGTGGAAAGAGTGTCATTTTGATTGCACATTATTGACTGTAGAGTAGGCTGATAAGATTGTGGTTATTAATAAGGTGAGTTGCAATTGCGCTCGAGGACCGAGTTTTGGTCGCAAGACACGGGGTTCTGGCCTTCCTCATTGAAATCAGTCTTCCGTCTATTGACAATCGCCTGCCGGACAATACGCGTGGGAAAGTCGTGCACACGGACAAATACATTTAGTTTTACAATTAAAATCGAACCGCGAAGCGACACCGCGCGCCGTAAATCTACCCCAGATTGTATGCGTGAACCGAGGCAAAATGCCCTAGTTCAGCAAAAACTCTTCCATTTCAGTTCGTTATGAGGGAATCCAGAAATCGGTCCGAGGGCCCTTGGTTACTCGCGGATAACGTGCTGTCAAATTATTTCAGAATTGAGAGTTTCGCTAAAAACTGTAGAATCGCGTTAAAAATGAGAGCTCACCAAACAGGATTCACGAAACAAGAATTCACAGAAATAGTATTCAGTGGGCGCAGTGTGCGCAGTGTGCGCGGGGTAAGCACACTACTTCTGGTCCCGCCCGCTAAATCCCGTGTTTCTCGTGAATAGCTGAATGAAATATCAAAACTCGGCGAGTTGTTCTGTGGCCGGCACACACACGTGGTTTCAGGCTGTCTCATGGCCCGACAATGGGTACATCAGTGAAAATGCGCTACTGAACAGAACGCATAACGCACGTGGTGCAAACAGGCTGTCCAAAACCATAATGGCTTGACCTACAAGAAGTGCGGGATGTTTTTGCCCAACAAATTTGATCAGCACGTTCTTAGGCATGCGAAATCAGTTGAGAACTCTATGACTCTTCTCCAGCATTTTTTGTTGATCTACGTAGATCAAGCCAAAATGAGACACGCTGACATCACGTGATAACCTGGTTGATACTACGCGTACGGCTTTCCCGGCGGGGCCGTGTTTCTCATTGCGGTTTGATCTACAAAAATGCGGGGAATTTTTCCCCCAGGAAAGTGTGACGTCAGCACACTCAGTCTGCGTCTCTTCTCCCACATTTTTCGAAGATAAACCAAAATGAGACATTTTGTCACCAACACACACACACACACACACACACGCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACATCATATTTGACGGGCAAAATCGGCCCCATAATTACAGGGAATAGTCGAACACATCGGAAATCACGAAACCCTACTGAACCCCATGAACGGAATCTGCCCTACGCAAAGCTCGTTCAACGACAAATGATGGGAGATCAGAAGCCACGGAGGCCGGCGGTCGAGCAGCCACATCCCGGTACCTCAGCGCCGCGTCAACCAACGTGGCTTGCAGGACCATCGCAGGGTAATGCAATGTCCCTGTTTTGTCGACTTCTTTAAGCCAATCTGCCAGTAGTGTTACTTCTCATGATTAATTGTTTTTTGTTCTTGTTAGTAGCCAACATTTTTTGATGGACTTGTTGGGATTAATTTGTAAGAATACCTAAGGGATACAATTATTCATTCATTATTAAAATTTGGGCACACAAATTCGATTGTGGAAAAACTGTACAAAAACATTCTTGCAAAAACGTGGAAATTACTCAAATAAACTCCAGGTAGTCGTTGTCGACATCGTCTCGCTTCCGCATCGCTGAAAATCCATTTTTCACTTTTTTTAAAGCAGATGCTAACCGGGGCCTCTCCGTGACCGGATCGTGTTGTTCCATCCGCGGATTATGAGAGTAGGAGCTTATGCCACGTGTCTCATTGGCAGCTTGCCAATTGTTCGCAGACAGCCTGTACGAGTCGGTCAACAGTGGACCGTTTAGAGTCTGAAAATATATAACGGGAACACTAAAATTTTAGAAGCGTATTGTGCAACACATTTGACGCGCAAAGTATCCAGGTAGCGAAAACTACAGTAGTCCTTTAAGTGACTGCTGCACGTGGTGCCCAGCAGGGCTGGCAATTTTTTGGTTCTTTGGTTTTTCTGGTTTTTTGGGACCAAAAATCCAAAAAATCAACAACAAAAACAAGTTACCGTGTCTCTCGACTCGAGACTATTCTGTATTAACATACATCGAAACATGTATTTTAACACAGTCGTCACGTCATAACCAATGAAATACATTTGGCGACATTACTTGATTAACCCCAAAACACCTATAAAACATTTTCTGGTTTTTTTTTGGTTTTTGTTCCAATTTCAATTTTTTTGTTTTTTGGTTTTTTTGGTTTTTCAAAATAACTTCAAATTTTTGTTTTTTGGTTTTTTGGTCCAATATTTTTCTACTTGGTCCCTGGTGCCCAGCTGTCCCATTACGGTTTGATGTACAACCAAGTTAGAATGCGGTAATTTTTTGCCCGAAAACATGTGACGAGGTCAGCACGTTTTTAACCATTGCAAAATCCATGCTTCCCTATTGTTTGTAGTTCAACGTAGATCAAGCCGAAAGAGACACACTGTGAGCGCGTGCTATTGTAGTGCTTGTGTCGATTTACGGGATCATTTTTCGAAATGATTATACATATAATAATCGATAGAATAATAAAATTATGGAAAAAATAATCGGAAAATAATACGACAAAAAGGAAAATTGAAAATCGCTGTCAAAATTCGAAAAAATTAATTGCGAAAATTGAGTTGCCGTAAATCGACACAAGCGCTACAGTAGTCATTTAAAAAGGATGGTCTACTGTACTTTTCGCTACGAGATATTTTGCGCGTCAAATATGTTGCGCAACACGCATTCTCAAAATTTTAAACTCTCCGCCTATCACAGCTGTGTCTCGTTAGCCCTGTATGGGGGCGGATCTTTCAGCGGTGGAGCCCGATAGAAAAAATATTTTTTCTTCGATTTTTCAGAAAAAATATCGATTTTTTCCGATTTTTTAGAAAAAAAATTTTTTTTTTTGATTTATCACAAAAATTATCGATTTTTTAGATTTTTCATAAAAAATATCGATTTTTTTTTCAGATGTCCAGAAATCCATTATTTTGATTTATTTTTAATGTTTTGAGTTCCATTTATCTGAAATTTTTTTTACCTCATAATGATTGCCCTTTTCTTCCACTGCCGCCTCGCTTAGTTCAGGGTAGTGTCGAGTAATTCGTATTCGATACTGTGAACGTGTAAGCGACAGTGGAATAACCCGGTAGATCATAAGTAGTACAATATGGCAAAGTGGATTACTAACTGAAAATTATTGGATTTTTCTCAAGTAATAAAGGTGGGGAGATCCGAAATATGTGAAAAATATTTTTAATTAACAAATTTTCCCCTGATTCCCAATTTCTATATGAAAAAATTCAAAAAAAAATTTTCCAGATTTTATATTTAAGCTTGAAATCGCTTGAGCCCGCATCACTATTTACAAAAGCTTCCCCAAAGAAATTTGAGAGCGCGCTTGCTTAGTTTGTTTTTCTGCTCATGCTAATATTGTATTTATTACCGCCAAATTCAATTTAACCGGTTTCATTCATTTTTGTCGAAAAAATATATTTTTCAGGAAAAAACCGGTGCAAAAAAACCAAAATCGACAAAAACTAATGAAATGCTGGCTGCTAAAAATTGAATTCGGCGAACCGAATAAAAATAAGTTTTAAATGAAGAAAATTCTATTAGGAGCAAACGAAATTCGCCATTTCAAGCTTAAATATGGGATATAATCAGGGATTTTTGTTTTATTTATATTTATTTCACAGCTTGATTTTCTCAGGGAAACATTTGGGGTTAATATATTTCACAGATGTCGGTAAGACAAATATGATTATTTTTTTACAAAAAATAACCCCCACCAGTAACAGCGTAGATAAATTGAGATAAATGCATGATTAACCCGGAAGAACAAAAGTCGGGATTCTGTTGGGCAATGCTGGAGTAGAAGATCGAGATGCTTGTACAATAGTAGGGCAGGAATGAATCAATCATCTGTAATTTATTTTTTTAAAGCTGGTACAATCCACGTGGTTCAGAGTGTCTCATTTCGGTTTCCGAGCTACTGTTTTGTAGATCTACAAAAATGCGGGAGAAGAGACGCAGAGTTCTGATTTCGCATGGTTAAGAACGTACTGTCACATTTTACTGGGAGACCCCCAAAATTTCGCCGCTTGTAGATCAAGCTGTGACGGGACAGCTTGGCACCATGTGGGTGCCGAGGGGAGCTTTTTGGTATTTTTTGGAATTTCTCGAAAAAAACTTTCATCGATTTTTTTGAAACTAGCTCTTTTAGGTATAGAAGAAAATAGTTTTTTCTCATCAACGCAATTTTTAGATCAATATTTTCGATTATCCGGTGAAAATTGAAAACTTTCTTTTTCTATGTTCCATTTTGATTTTATAAATTTGGGAAAACCTAATATTTCGATTTTTTTTGAAAAAAAAACCAATTCAATAATTTATATATTATAGGCCACTCTTTTTCTCTAATTTCTTCTGAAAAACCTTAACAAGAAATTTTTTTTTTTTTAAACCAATTTTGAGTAATTTTTTTCTGTAAAACATACGATTTTTTTCCAATAAATTGCTAGTTTTTTCTCTCTTTCGGGTACTTGGACTGTCTCTAATTTTGCTTGCTTTTTTCTATATTTTTTCTGCGATTTACGATGAAAAGTACCAAAAAGTCGGAAATTGTTTTTTTTTTTCGATTTTTTAGGAAAAAAAACGATATTTCCTATAAGTGTTTTTTTCATAAGTAAATACTTTTCTCCTTTTCCTTTTGATCTACAATATTTCGACTTTATTCTGGAAAAAATTTTTTAAACGTTTCTTTCTGAAACAATTTTCAGACCCAAATTTTCAATAATTCAATAATTTTTCTAGATTGTGCGACCGAAATATACACATGGTTTTCAATAAATTTATAGTGTTCTCCATTTTTGTTGATTCTATTTTACTACTATAATTTTTTCAAATTTTCGAAAAAAAACATTTTTTTTTTGGAAAATTTTAATTTCAATTCGATATATATAAAAGTTCATATTTTCATCTTTCATCGAAATATATATTTTTTGATTTTTCAACCTTTAACTTGTTTCATTTCCTTCTCTCTGAAAAAATCGGAAAAATTAACAGAAAAATCGAATTTTTTAAAAATATATTCCGATTCGCCCTACCATAATTTTTATGACAAAAAATCGGTGTGCTCGTTATTTTCTACAAAGACTCAAAACCTCAAAAAACATGCTGGGCAACGTCAAAATCGCTCGATATCGAATCTTCAGCTCAGTCTCATACCAAATACACCGCATACAGAAACATCGTGCAAGGAGCTTGAAGAAGAAAATGAGCGCGGTAGATATGCACACTTTTCCACGAAAATTTCGGCCGAAATCATGAAACAGGCGTGGATTGAGCACAATTCGATGGAGCCAATAGCCGGGAAGAGCAGCCGAACCTTTCATTGGGATCTGTGTACGTTCGTCTAACCGATAAATGTTCCTGCATTGATCGGATACAGTAGACGAGCAGCCGGACAAATGTATTTTGCAAGTGGGATATTCTGAAAATTTTTGAATTTTTTCCGAATTTAAAATTTTAGTTTCTCGATTGTTTTGAAGTAAAAGAATTGATTTTTTAGAAAATTATATGTTTTGTTTAATTTATTTAAAAATCTTTGAGGTAAAGCGCAGTGGAGTAGCGCTAGTGGGGACTTTAAAACTGCCTACGATACCACAAGGACCGAATATCATGATAAAAAAATTCAAATGGAAATTTTTCTAAATTTTATAGGTTTTTTTTTGAAAATTGAACAATCTCAGTTGTTTTTGCCTAATTCCAATTTCAATTACCGCTAATTTGTTCGGTGGAGCGCCACGTTTTTATATATTTTTAATTTTTATGTTATTTACCACCGATTTTTAATGTTTTCGGTGTATTTTTGCTCGAATTGAGAAAAAGCAAGACAAATGCAAATTTTCAATTAAAAAGCACGCTTACAGGCGTAAAAAACATGACAAAGTGCCGATTTCGATTTCCAAAATTAATTAATTTCATTGATTTACGAACCTGTAATCGTGCCGCTTTTTTAATTGAAAATTTGCATTTATCTTTTTCTCTAAAAGATAATTCGAGCAAAAAAACGAAAACATTAAAAATCGGTGGAAAATAACAAAAAATAAAATAAATAAATCTTGTTAAAAACGTGCAAAAAATCACGCTCCATCGAATGAGCAAATCCAATTGGCGGTAATTCAAATAGTAATTAACAAAGACTGCGATTTTTTTCAATTTTCAGAAAAATCGTATAAAATTAAGAGTGGTAAATATTTAAAAAATTATTTTATCATGATATCCGGTTTGGTACCGTATTTTAAAGCAATTTCCCCACTAGCGCTACTCCACCTTTAAAGTGCTAATGAATTTTTTGTACGTGGTGTCAGAAAGTCCCATTTCGGTTTAATAAAAAATGCGGAGAGACGCAGATTTCTCAATTACGCTGCTATCGTTAAAAACGTGCTGACGTCACATTTTTTTGGGAGAAAAATTCCCGCATTTTTTGTAGATCAAACCTTAATGCGACAACCAGGCACCACGTGTTTTTACAATTACACATTATCCTGGAACTTTCCAGAAAATTTGAATTTCGCGCCAAAACTTAGGGGTAGGTCCCATCATGATGAGTCACTAACGTCAAACCGATATATGTAAAAAGAACCAATGCCAAACTCAAATTTTCTTAAACTACAGTAATCCTACAGTAATCCTGTACCCCTACAGTACTACTACAGTACCTTGGCATTGTCCCCGACCAATATACAACCCAAAAATATACCTTCAAAAACAAACACGTAACTTTTCCCAAACTACAGTAATCCTACAGTTCTCCCACAGCTGCAGTACTACTGTACCTCTTTAGAATATTTTTCTGTTTTTCGATTTTTTCAAAAAAAATTCAGTTTTTTCAAAAATTGATTTAAAAATATTTCAAGTTACTTTTTAAAAGCTTTTCAAAAGTTTTTCAATCTGTAAAAATAAAATTTTACGGATTTGTATTTTTTAAATTATCTGAAATTTTTCTCAAAAAAGAAGACTTTTTTTTTCCAGTTTTCAATTAATTTCGGTAATTTTCAAAAGTTTTAGGTTTAAAAAACAATTCAATTTTTATGTACCTTAAGATTTTATCGACATAAAAATCATTAACAACTACGATTTGTAGCGGCAAACCTTTGTTTTTGGCAGTGGAGCGTTGCGCCTCGTCTTCAAAAAGACAAAATGGTGAAATCCCAAAAATCAAATAATTGTTCCGCTACGACAAAATACCGCTAAATAGTAATTTTTCATAGTAAGTTCCTTTTCAAAAGTGGCACAGACCTGATGAAACGTGTCGTTCACCTCCTCCGAGTCCTGCCACGTGAGCTGGTGCTCCGGCATGGCTGATACATTTGTGAATTTCGCTAAAACAGAAAAATATTATCAATAAGCGGAAAATTTCGTGGTCTCAACACGACAATAAATAATAAAAAGTATTCGTGGTGAGACCCGTGTTGTTTTGGAGCAAAATTCTCAAAATTGGGGTATCACGTTGTCAGCGTCCCGTTTCGGTTTGATCAACAAAAAATGCGAAGTGATGCAGAGTTTGCTGACGGCACATTAAAAAAAATGCCCGCATTTTTTGTAGATCAAACCATAATACGACAGCCTGGCAGCGCCACGTGCGGGGATTAAAACCCGAGCCGCACAGAAAAAAGGCGGGAGTTTTTTCGCAACATCGCGGCACGGGGCGGTTTTTTGTTGACCTTTATCAATAGTCTAGATACTTGCGATTTTTGCAAATTCATACAATCAACAATAAACCGACCGTGGCGCAGGGTTGCAAACTCTCTTTTTCTGCGATGCTGATTTTTTGCGAAATTCACGAAATCAAAATTACAGCACACGTGGTGTCAGTGTCTCTCATTTCGCGGCTTGACCTATGTAGATCTAAAAAAAATGCGGGAGAAGTGACGCAGAGGTCTCAACTGATTTCGCATGGCGCCACACATTTTTGGACAATTCTCGCCGCATTTTTTGTAGAGCAAACCATAACAGCCTGGCGGGGATTAGAAACCGCGCCGCACAGAAAAAAGGCGGACCGTAGTCTAATTCGCAACACCGCGGAACGGTTTTTTACTTGCATTTCAGATTCAAAAAATCAACAAAAAACCGTGCTGCAAGGTTGCGAATTCGTGCTCCGCTCCGCATCTTTGTGCGATGCTGCTTTTTTAGCGAAATTCACGAAAAAAAAATAGAGAATAAAAGTCCATTTACCGATACAAGTGACTGCCGATAGACTTCGCCGATATACATGGAGAGAAGTGTAGAGAGTGAAATGTGAAGTTTATTAGAAAACAATTTTTTAAAATTATATGTTCATGAGGAAGATTTGCGGTAACTGGTAATCGGTTTTAATTGCCTTTTCGAGTATATGAACTATTTTAATCACTTGATGATCGCTAGTACGGCTTTGCGCTTCCCATCTCTAGATGACGGAATCCACGTGGCGATACTGATCGAGTGTTGTTTTGGAGTGGTGGTGCTGTTGGTGCTGGTGGAGGGGCGGAATTGAGGCGGTTGCAGTGGATATTACGCTGATTGGATTGGTGGAGGAAATGAGAGAAATTTGCGAGCATAAATTTTTAAAAAACGAAAGAAAATTCTTTGTTATTTGGGGAGCAAGGCGAAAACGGTGTTTTTTTGGGTCAAAAAGTAATAAAAATTTACAATTTGACAGAAAAATGCGGCACTGAAAAGCTGTTTTTAGGGTCGAAAATCAAAAAAAAAATTTTTTTTTGCTCATTATTGTGGCAGAAAATGGCGAAAATCGGTTTTTTCAAGTTACATCAAAACAATTTTTTTGCATTTTACAGAAAGATGAGGATGTTTTAAAAGTTTAAAAAATTTTTTAAAATTTTTTTAGCGAATGGAAATTTTCTGAAAAATCGTGCAAATGCCTAATTTGTGCAAAAATCTTATCTGTTCAATAATTTTTAGAAACCACCGGTTTTAGAAGGGTAAAAGGCAAAAAACTGGATTTCCAGTGAATTTTATACTAACAATGGGAAAAATTCGGAAATTTTTTAAGGAAAAATCAGAATTTGCAATTTCTACACATATAGAAATTGAGGAGAACTCCTCGGATTGTTTGCGGAGTTACGATAATTTTTTCGGCTCAAAATTAACGATTCAGAGAAACTTTAAAAAAACACAATTTCAGTGAATTTTACACGAAAAACGGAGTAAAAAGCGTTTTTAGGAATTTCCAAGTCAAATTTCCGATCCTGCGATTTCAACCCTGAAAAATAGCGAAATTGAGGAAAATCTCGGATTTTTGCAGATAAGTAATATTTTTTCCAAGTAGCTGATTTCCGTCGCCAAAACCCAGAATAATTTACCAATTCGACGGTGGTGGGAGAGCCCAGGCTCTCGTTGGGCCGTGAGATCCGAGAACCAATTGTGCCTGCAAAAATCGAGTAAACGCTAAATTGATGTTTTCCGCTATTAAAGTGCATATAGAAATACGAAAAAGCAAAAAAGAAAATTTTTTTTAACCCCTGGAATCCGAAGAGCAGTTAGCTTGCGGATTGGACGAAAAGGGCCTAAAACTTCATTTTCCTGAAATTCCTCGAAAAACCCACTATTATGGGTAGTCGGAGATGGCTGATCGCCTCGTCGCTTGTAATATTGCACGCCTGGCCACCGTAGAGAAAATAAATGTAGACTGCACACTAGGATGATGGGAAGAAACGACAATCGGCATGCGTCTGGAGTGAAGAAATCAAGATTTTTCAGAAAATTAAAGATCTCTAAAGGTGTACTACACCCTTGTTGAAATGGCTTTCAAACATGCCTATGGTTCCACCCAAATATCATGATTAAAAAATTAAAATTCTAGAGTTTGTTTGAAAATCGAAAAAATCTCGGTTTTGGGAATGCCTAATTCCTATTTGAATTAGAGAACCGCCAATGATTTGTTCGATGGAGCGCCCTTGCACGTTTTTAAATTTATTTATTTTATTTATTGTTATTTTCCGATTTTCAATTTTTTCCGTGTAGTTTTGCTTGAAAATTTTAGAGAAAAAGTTAAATAAATGCAAATTTCCGATTAAAAAATCCACTGAAAATGCGTAAAACTAATATGCTAGTTTCAGGTTTATTGTCGTCGAAAGTCATTATTTTAACAGTTTGACGTATTTTTCACGTTTTTACTTTTTAGCAAACACATTAATCTTGCTTTTACTTTCCGATAAAAATACACAACTAATGAAGAAAACAGTGACATAATAATAATAATAATAATTAAAATAATTTACACTATTACGCTCGCTGGGAGACATGAGGGAATACAGAATACATTATCATTGTTCGCTTGAACTTGGTAATTGGTGCAGGGATCGTTTCCATTCCATTATGTTGTCCTTGTACTTGCGTTGTCCTTGAGTAGACTCCCCCATAGTGGGCGGGCGATTAGTGTAAAACAACCACGGAATGAAAAAATAGAAGAAGAATAGAATATATTAATAAAAAAAATGAGGACTGCAAGCGCGCTCCAAATAAACGATCGCGTTCAATTGGCGGTAATAGTTTTCAAATAGAGGCAAAAACTTTTTCAGATTTTTTCAATTTTCAAAAAATCATATAAAATTTATAATTTTTTTTTGAAGCTTTTTAACGTGATATTTGGTCACTGTGGTACCATAGGCGTGTTTTAAAGCCCCCACGAGTCCACATTTAATAATTGAAAATTAAAAATTCTACCTAACAATATCGAAAATTCCAGAATCTCCTTGATTAAAACTTTATTATGCCTAAAGAGTCGCGTCCACACGGAGAGCGCAAGAAATCTGAAGAATATTTAGGATTTTCAAGGGAAAATCAGATATCGGTTTTTTTTAGCAAAATACCACAGAAATTGCGTATGGAATGAGTAGAAGAGCCGGGTTGACTTTCCGGGGAAAGTTTCGACGTGTGATACTCGTCTCAGAGAGCCTCATTCCCAAGAATCCGGTTGCGATGCTGAAGAAAATCGATGGAAAAAGTCTAAAATATTACCCCCTGAAACCCTACCTAAAAATCAGAAAATACGAGAAAATATTGATTAAATGAGCCGGCACATAATTGGACCAGCACTCCATTCAAGTTTCGAAACGTTTCGCCGTTTGAAGTCCAGAAGCCGGGAACGGATAGTGGCTCGAAATGCTCGTCGACACTCATTTGACTGGCCCTGTAGAGCCCGATGATGGCAATGGCGAGCATTCCCACTTCCACATGGTGTCAGGCTCTGAAAGTTAAAATTTAGCTTTTAGACGGAGAAAATCGATTACTTTAAGTGACATGAACTTGATCGAAAAGCCAGCGTTACGGGTATTTGCGGTGCAGGCCCGATTCCCGACTACTCGACACAGTATTGGAATTCGAGCGGATACTAACATCTGCCATTTTTTCTCTGAAAATTCAGAAAAAATAAGTTTTAAAACAGAGTCTTAAAAATTAACGGAAAAATTCGAAACTTTTTTTTCCGCCATTGACAATGTGCCTTTAAGGTACCGTAGCTCTTCGTGTGAGACCACTGCGCCGGGCATCTGATTTCTGGGAAATTTGTTTCGAATCCTACGTTCTTTCTTTCTTTTTGTTTCGGTCATCGTTTTTTTGTTGCTCAAAAAATCCAATTTTCAGACACAAAATGTCAGAACGCCAATCCACATTAATTTTGACTATCAAGGTATCGTCATTTCCTCCGGACGATAGATTCGGTGACGGACCTCGTTTATCCAGTTCATTTCAGCAAGCTCTGTACGTGAATTCCCTCCGATTTCATATTTAAAAGAATAAGCTCGTTTTCAGGGAAAAGCGGCCCAACAATGTACGGTGTCTCCAACGCATTTGATTTTCCAACAAACTTGGAGAGGAATCTTGATAATATCGAAGAGGGAAAAAATCTTGAGACAGTATTTATTTGATTTGGGCCCACTTTTACGATCTGTTAACTCCTGATTAGACGTCGATCCAGAATCCCGCCCTGAAGTTCGGTGAAGTCATCCTATGGAACGAATCGGACTGTGATCACGATGAGAGGATAATCCTTCATATCAAACGAGAAAAACCAATTTATGAAGCGTCTGCCAGCCAACCGTGAAATGGAGACTTAGTATGAAAGTCGGTCGCGTCATCCAGCCCACCGACCTCGTTCTGGACGCCAGTATGCACCGTCACCATGCGTATGTTTCTTCTTGATTTTCGTCTCTCTAACCATATAAGTATTTATTTCAGCAGAGACAGAGGCGACCCGAGCGGAGCCAGACGTTTGGCTATACGCCTGGATTCGATTCGAAACTACCATGAAGGTCTAGACCCTTTCAATATGACTGCAACATTCGAATCTTTTGCCAGTTGCGATCTATCCGACCCAGCACGCGTCTGTGAAGCGGTATTTCCTTTAAATTTTGTACGGGATTTTGAACAAATAACTTTCACCCGGGCATGGAACGCAGGCTCTCCTGACTCTAGGAAATTCGGAGTTTGGCGCGGATACCAAAGCCTGCTGATAGCGACGGCGAAATTGATATCGAGCAGAAAGAATGCTGGAACTTGCCAGAAGACAAATGCCGATAAGGTTGCTTTGTGGATTCTCGTAATTAGATTTTGCATCAAGATGCAGCTTGGCCTGTAGGTCGGGAACGCCTACCGACTTGCGAAAACTCTCGCAGTTCGACTTTATTATCCCACTGCAGAAGCCATTTTCACCCGAGGAATTTCACGGACAAGACCTTGATCTACCCAGCCGTCGGAGAATAATTTTCATTTCAGTGCTTTTGGTCGATGCAGCACAACGGTTTTCTGATCTATGAGCTTCAGCCTGTTCTTCTCAGACAGCATGTAACCTCTGTCAACGGAAATTTAAGTTATAATATTCATTTCTTTGTCCAGAACCTAATTTTAATTACGGCTCCTTACCCGCGTCGTTCCTGCCAGTATCACCTGAGGTCTCTTCCGTTGACAATGAGGGCACTCTAGGATTGATTGATGACCCACACCATCTTCTTTCATTCTTCGTTCATCATCTACAGCTGGTTATGTCCTTGAAGGCTATGGTAATCATGAGTGGTTCTTATTTTGAAACAAACGCTTTCAACAGGCCGAAGTTCGTGCTGTTCGAACCTCAGAAAACAAATCTGTCCGTTACCGCATTGTTCGTACATCGGGATGTCCATTTTTGAGGCCCAGGGTCCTTCGTTACTCAGGTCTCTAAAGTTAAATTAAACTCGTCCTTTGCACCCCTGAATTTTTCAGTTCGTTGTTGGTCCAGTCAAAGGAATCACTCGAATCAATGAAGACTCATTTGTGCCAAACATCCGAATGTCCTACTTCAAGATCCCCAATAACTTGAAGGAAGGAATCGCTATTGAGCGGAGGAGTTCAATTCGTTGGAAAGTGACAAGCTGGCGACAGTGAAATTATGAACACCGAATCCATGTCCAGCGTTCCTTGTAAACTCCGGTCTCTGGTGATACGGTGAGTCTTCAATTATTATAGTTTTTATTCTACGAGGAAAATATTCAGCGCTTGTTCCAAGTGTACTTGAAGCCACCAAGCGATCATGGCAGTTGGCGGAGAGTGATTCGATGGGATTGGATTTCAGCCAGATTACAGTTGGAGACTCCTTGGTAGAGGAAAGTGAGGGTGTCAGCATGATAATTGTAACTGAATTTCGAGTAAGGTTCCTGGCATGGGTGCTCCGTCCATTACTGGCTTATCAAGGATTGCCGTGGCTACCATCATGGACGTATGCTCGACAGCCATCTGTCCTCCGTTGATTGCGATGAGTATCGCCGTCGAGCAAGAGCAAGATCGGCCAGAACTACGCCAGCTGGTAGTTCCATTGAGAGCATCAATTCAAGCACATCAAGAGCATCTGCAGCTACTTCGAGGCTCAAACGTAAGTTTTTTTAAGGTTGGAAGATGATAAAAACAAGTTTTTCATCGATTCGTTGGCACTTCAAGCAGAATTCCATCTGGGTACTAAAGCTCAACATCTTCCAGGGTCTAATTAAATATATACGCATCCCGTTTTCCCCCGTGGGTTTCAAATGTTCTGCTCATTTTTAATCTACCCGTTATCCAACAAACATATGTTAATTTAAACGTCAAGTTCACCACCATCCCATTCCGCACAACTTTTCTCTCGTAATTTTCTCTTAGTGCTCAAATGAAGGAGGTAGGTTATTCTAGTGAATATACCCATGTTAAGCCGCGAATACATCCAGAAAGTCCCGGCATCAAGCCGGGAGATACTCCCGCCATAATGATAGTTGAACGGTACATCCAAGATAGGGTAGCATCGCGATAGACGTGAGCAAGTTCGTTATGCACTTGAAAAACTGAAATTTCAGAAACGAAGATTAGGTGATCGGCAGAAGGTTAAAAACAAACAAATGAAATATAGAAACGAAGACAGTGATCGACGTATTCCGAATACGAGAAGCCATTCCCGGAGATACAGTGATAAGAATCTGATCGAGAACACAATGAGCACACTACCACCGGGAACATGAATTCCATGGAAACACGGAGACAAAGGTCACAGTACTGCAAAAAATGCGAAATTTTTTTGCTTTAAAAAATGCAGCACTGCCGGGTCCCACCACGACAAATTTGTTGTCAGTTGACCAATAGAGTGTGCGCCTTTAAGGTACTGTAGTTTCAAACTTTTGGCAATAGATTTTCCACAGTTTTCCCGTGAAACAAAAGTTTGATACTACACTACTCCTTAAAGGCGCACATCTTTCCGCATTCAACTAACAAAAGGTTGTCGTGTCGAGACCCGCGGCCACTGCAATTTTCGTAGCAGAAAAAATTTGAAATTTTCAAGTCTTGAGGATAATATATAATAGTTTTACCTGAACAATGGGAATTTGCATTTACAAACTATCCAGACAATCGCTGAACCCGAAAGTATCACTAATAACGATCGAAAGTGTCGCGGAATGTCACGTATCGATTGGTAGATCATGAATATGTTGCCAAGTAACGCGAAAATCTTGAAAAGTGGGGGATTTTGCTTTTAAAAAAGCCAAAAAAAAAAACTTAAATTCGCCAATTCCCAGTTTGAATTCCCTCCAAAATGAGAACTGCAGGACCCATCAGCGATTTGAGTGGGCGGAGTCCGAGGGCGCTGATTGGTCGTGCAGTTCTTATTTTGGAGTGAATTCAGCCAAATTTGAAACATCTCGTTTGTTTTGCAATTCTTTTGTGTTATTTTCGACATGGGGTTCATTCTGGCTTTCCTCATCAATGGTGTAATGTCGTATTTAAAACGGGACAACCGGGACGTTTTTATGAAAACACTCAAAATAGAACGGGAGTTACAAACTGGGCGGTTAGAAAAAAAGATAGGGCGTAAATTTTAGTGTATTCGAGGCAAATAAAAAACTGCATGTTTCCAAGTCATTAATCTGCATGAATTGATTAAACTGACTAAACTCACAAACAGAACTTTAAAATGTGCAACTGTAAAATCATGAGGTATAGAAATTGTCCCGTTATCCCGTGATAATTTTGAGAACGCAGCGGGACGTCCCGTTCCCGTGAAAACACTCAAAAAACGGGACTACGTGACAAACGGGACTCGGGACTTGACACCCTTGGGCATTCCTCATTAAATCACGCTCCATTGATAATCGCCCTGGTCGTGTACTCCACACGGACAAATCACATTTAGTTTTACCGAACTAAAATCGAGAGAATTGGCAGAGTATTTGCCGCCTGGCCTACGCCCGGCAAAAACTTCCATGGATTCAAAATATGGGCGAAGCCAGAAATCCGTGATATTTTCAGCACATTTTTTTGCTTCGAATCTCAGTTTCTCACCACAACGAACCACTTCACATTCGGTTGCCGCCCCCTTCGAAACGTGGACTTCCAACTGCATTCACCGATTCGACACTTAGCTGGTACTGACATCATCATATTTACCAGCTCATACTCGAACTCCGGAATATACGGCACCACATAAATCGGTGAATGGCTGGTTCTGGCGGTGGCGGCTCAAATGACACTGTTCCTTGATCTAAAATTTGTTTTTTTCTAAACAATTGTCACTACCAAATCAAAAAAAAAATCTTACCAGAACTCATAATTTTTGGATTTTAATTTCGTAAATTGCAAAACAGAAACTGTATTGGAATTTTTTCGCTTTTTATTTATGGGAGGGGGAAATTCTTTGTTGTTGTCAATAAAGTAAAACAATTACAGTAAATGCCAGTACAATAGATTTTCACGTGTAATATATTAACCAATTACTATATTTTCAATAACTCTGTCCTCTAAATAGGTAGTTGGGGGGAAGGTGAGGGAAAATGGAAATAATGAAGTGAACTGTTTTGCGTACTTGCGATAAAAAAATCAATAAATGGGAACAAGCCGATGATAAACTGATAAACGTGAATATCGAGAGAGGGAGGAAGAAAGCACGTATACCCGTTAATGAAATCAAGTTAATGGAATTATTTGGTTTGTGAAACAAAACAACGAAAATGAATATCAATGTTTGAGCATAAGGAATGAGGGAATGGCACTCTGGTGGTGGTGGATAAATGAATCGGGGGGAACGGAATCTATGGAAGTCTAGAATACATCGCATCGAGTTTTCGGGTGAGTAGTGATCCTTCAGGTTCGCCAGACGCTTGCTCTTTCCACGTTCGCGTGAGAAGATCATTCTCGACGCCGAATTGCTCGGAGAGACTGATATCGCGCACTTGCTGGAAAGACAAGAGCCGGCTTCTTGCCAACAACCATGTCATCGAGGATCGCCTTTCGAGTTGGTCGTTGTTGCACGAAAGCTCTTCGAATGATCCCTTGATTCCTTGGTCGGCGCAACATCGCTGGGACGAGCACCTAAGGGAATTGAAAATTACATATATATATATATATATACACTCCTCAACGCCGAATAAATATTAGAGCGCGCTTACTGAGCTTCGCGTTCATCCGCGGCATTTTTGACTTTACACTGAAAAAAGCAGATATTTCAGATTTATCGAATTTTTAGCTTTGTTACAATTTTTTTCATTTTTCGAACACTTTTGTTAAACAGTGAAAACTGAATTAAAATGACTAAAATGAACTTTTTTCGTTCACTGGTTAAGGTGAAATGGTTGGAATTTGAAGAAATCAAAGGGATTTTTCTGAATTTTGTAATAATTTTCTATTAAAAATCGGTTTTAAACCATTTTTTGACCCTAATGTCACAAATGTAGAAACCGGTTTTTAACGGAATAGAAAATCTTTAGAAAATCACAAAAATCCCCGTTGATTTCTTCAAATTCAAACCAGTTCACAACCAGTGGACGAAAAAAGTTCATTTTAATTGTCATCAAATTCGATTTTCAGAGTTTAACAAAACGTTTGAAAAATGCAGAAAGAAAATTTTAAAAGCTAAAAAATCGATAAGAAAATATGCTCTTTTGAGCTGGAAAGTCAAAAGACCGAAGATGCAGAAATGCGAGGCGCAGCAGAGGATCGCGCTCTAATAATCGGCTTTCGAGGAGAGCGTGATATAATATATTTTTTTTGAGAAATTTTGCAAGTATGTTAAAACGAAAAAACCAACCTCAGCATCAGGTACAACAATAGCAATAAGACGTCTTCAGGCTCATTCTTCATCAACAGATGATTGAGCGACATATTTCGAGCGGACATACATTTTCTCAATCTTCCCGGTGCCACGTATCCTCCTTGCGAGAGCTTGAAAATTCTTGCGATCCAAAATTTTCAGCGTTCCCTCAGGAGTCCATCGTCCAATGTCTCCAGTATGCAACATCCTCCTCGATCGTCTCCTTCGTCTGTTGCTCTTATAGTATCCCTTGAAGACGATGTGTTCCTTGCGAACAGACACCTCGCCGGCTTGATCCTTCGCGTAATAGTTCAACTCGGGCACGTCGACCAGCTTGATCTGACACGATGGGATTACCATTCCGACGTGTCCGGCTAGCGAACTCTCCTTTCATCGAGACAGTCCAAGCGGCGACACATTCCGGTTGACCGTAACCGTCGACGGCGACCCATCCCATACGAGCGGCACGAACGAAGGTGAGCACATGCGTCGAAAGTGCGATCGTGATCATCAGACGCACACGCCCTCCGAATCCATCGCCAATCTTTTCGAATACCAAATTGTCGAAGAATCGGCCCCGTCTTTTCTGATATTGAAGCTGGAAAAAAAAAGAAGATATTAAATACTATCAAATCATTCAGATCTCTCATGATGCCATATAGTCTCTGGCCTTGTATGAGATAGCGAACTCAAACAACATCTTCTTCAAAGTACTTCACTTCCGACATCACTGATTATCGTAAAGCCGATTAAAGACACGAGAAATCGGGCACCATTGGCACAGTCGGCCTCAACTCTTTGATATCCTCGGCCAACACACGTATGTGGTCACCGCGTTGGAATCCGACTTTCGCGCCGACACAGAAGCACACACTCTCGATGACTCTCTCGGAGCGTCATGTGAGCCAACGGAAGGAAGCTGATCATCGAATCGGTCGCATGCCACTGTGCTTGTAGAAGTCCATACACACACGTCGGCGATCACGTTCGCGTGAGTGAGCATCACATTTCGGTGTTCCAGTCGTTCCTGACGTGAAGCATATGGTCGCAAGATCCTCTGGTGACGTTTGGTGGACTGTGTGCTGAACGAGTCTTGCGTTCTTTCCTGTCTCGAGATCAAGTGAGCACCTCGACTCCGAGACGATGACGCAGTCGTTTTGAGCTCCTCGGTGACTGGTTCCATCAAGCGTGCTCAAACTTGGGCATTGCTCCTTGAACTTTAAGAGACCTGAAATCAAATTTCCTTTTGGTTTTAATTTCCTTATCTAAACTCACCAGTGGCCTTTGAAATATCATCACAGACAACTTTCGAATCTTGATCTCTGCCTGATTCAAAATGAATATCCAACCGCTTCTATGATCCAAGGGTCTCGTAGATCGGCACAGTCTCATTCGAATAGTTGTAGGTGATTCGGTGATGATCCATTCGGCGCAGAGTTGCTTCGATTAGATCCCAATGTTCTCCGCCGTTGCCAGTCGGAACGCCGGAGCTCACGGAACGCGACGGACACTTTGTCGGCTGGCTCAGAATCGTATTGTACGACTCCCACACGTACGAGATTGAACCATCCGACTGTTATGACTCGACGTCCGAACATCGGCCCGGTTCGAGAAAGGGGCTCCACGGCGAACGACCACCCTGGTAGAGGGTGCGCGCGTCTTCGAACAGGAAGCCTCGTCAGTTCGTCGTCCTTCAGGTGGCGCTGATGCGGGTACCATCCTGGAAATTAACATTCTAGTCGGGGGGTTTTTGTAATTTTTTTTTCGCTCTTTTTCTATTGTAAACCGAGCCACGACGCGACACGCCGTAAATCTACAAGCCCAAGTGGCCTAATTCGGCAAAATCTTACATTTAAAAATATGGGAGGGAAGACAGAACTCCATGATTTGAGAATAAAGGAGGTAACGGTTCGGGCGACGCCATTTTGAACGCTCAGTATCGACATGAGCTCAACAAATGAGATCGTAATGAAACTGGTCAAAAATTTTTATGGCGGTTCAAAATGTTGAAAAACCTAAGTACACTGATTTTTATCCGGCTAAAATCACGAATTTTCCCATTTTTCCGTGTCACATCTGTTCGAAGTTGGATTATTTTCTTGGAATTATCGTTTTTTATTACTATTTTAAATTGGTAGTTTATCTCATTTAATGTCGTCGATTAAGTACTTTTAAAGCCGATAGATAACCAATTTCGATATTTCGGGTCACCTATCGGCTTTGATAAAAGTACTATAAGACAAAATTAAATTAATTACCAATATAAGTAATAAAGGACATTTCAAAAAATCCAATTTCGAACAGATGTGACACGGAAACAAAATGAGAAAAATTCGTGATTTTCACCAAAAACAGTGTAATTTGTGCAAAATTTCTGTGAACCGACATAAAAAATTTTTGAAAATTTGTGGATTTGAGCAGCTTCATTACGAAATTCGTTCATTTGAGCTCATTTTTGGTCTATACGTTCGAAATTGGAACGTCCGAGCCGTTGGTCCTCCTCTCTTTAAGTTTAAAAAAAAAAAGACGGCATTATTTTGCCCAGTTTCTCTCCAAAACTCACCGGCAAAATGCGACTCTGATTCATAGGATCCGTGGCTGACATTTCCCGAATAGGTGACCCCTCTGAACGAGTAGGATCCCGACGGTCGATGACGAGCTACAAGTAGTATCCGAGGCCCTTGGTGACTGCGGCGGCGGCTCCGATATTTGAACGTCCGGTGGAAGGGAAGAGTTCGAGCTTGGTGCCGAAATGAAATCGACAATACTTCTGGAACTATTAAATTATATATAGAGAGGACGGGTGATGATGAGTCATCCAGGTTGTTGTTGTCGCGCTGTGCGCACGCCCGCACTGATCCCCACAAAACAAGACAACTTATTTGAAGTTACGAAATCGAAGTTTCTTTGTTATTTTATTTTTCAAGATGGTTTTGGTTTATATACCATGTAAAAAATACCTAGGGGTTTTTTGCGCGTTTGGACTCAAGTAGAAATGTTGAGCCTTTTCTGAAAAGTTTAATCCGATCAAAATTTTGGAAAAAGGTGAATTTTAGCGACGCCGTGGTTTTTCGAAATATTGATCTGCCATTAAAGCCCGTGGTGTAGTCAAATTTTTTTATTGCTTTAATTAGCGACGACTCAAAATTGTCCTTCTGTAAAGAAAACACAATTACCCTTCATAAAAAAACTTAAATGTAAAATTATCTAAAGTTTGAAATTTGACCGTGGTCAAGCGGCTGGAAACGTTTTTTTAATAATCGTCAAATAATATACAGTGCAATGATCTCATTGCGTTTTCAACTTTATTTAACTTTAAAGTCATGAACGGCGAGATTTGTTTTTAATTTTTCACCTAGAAATCTCGCCGTCCATCGGCTGTAAAATACCTAAATGAAGTTGAAAACGCAAGATAATTGCACAATATACTCAAAATTTGACGTGTTTTCAAAAAAAAAAATACTGTTTCCACCGTAGCGGCGACGTCGGTCAAATTTCAATTTTAACTGAATTTAGGCCATTCGCTTTGTCATAACTTGTTTTGAGGAGTTTTCAAGAAGTTTCATTATGAAATTCGGTGTTTTCAGACAATTTTGAGTCTAACTATAAAAGAATCGACTACACCACAATGTCAGATCAAAGTTAATTTCGAAAAAACTCGCGAATTTTCGCTAAAATTCACTTTTTTTCCGATCGGTAATTTTGATCTGCCATTAAACTTTTCGGAGAATCTCAAACATTTTGAGGATAAACGAGCAAAAACTAGTCATTGTTTGAGTTGCCAATGGTATATAAAACATGAAGACCATCCTGTGAAAAAAAAACAACAAAAACACTTGAAATTCGCAATTTCATAAGTTCTCCAAAAGGGAAAACATACACACACCTCGATTGAGACTGTACCCACGCAGCCGAGTCTGTGATAACCATTTTCTGGTGTTTCTGTGTTTACGTGGTTAATAGTCTTCTGACAAAAGAAGACATGAAACCGCTTCTAAAATGAGATTAAATTGAGGAAACGACGACGACGCAATAAGAGGTGCAAGGAGTGAGGGTGAAAATCGAAAAACAAAGAAGAGATCAACGTTATTCCATCTTTAGAACTTTCTTCACTGCCAGCAATTGTTAATAATAATAAGGTTTTTAGGTCGATAACTCTTTCGGTGATCAATACAAAAAGGGGTGAAAACCCGCCTCGACAAGCCTTTCGATCAGGCCAATTTCTTTATCACACTCTCCGCAGATTTAGGAACAAATTTCACCTCCCCGGCAAGGGGGCAAAAGTTTCGAGAAGTTGTGTTGCGCGCGAAGGGGATGGAGAAGATGGAGAAGATAGGCAAACACGTACACCTACTCAAACAAGTAGTAGTGATAATTGATTTGATTAGTGATTCGGGTGGGCAAAAGGAGCGAGAGAGAAAGTGAGAAAAAGCGAAGAGGGAACACGTGTAATCAACAGTGTGCCGTTCACGCCCTTTGGACTAATGCAGTTTTTTTGGTGGAAATTCAATTAACACTGAAAACTAGTTTTTAAGTGTTTACGCTGTAACGGGCCAGGTTTATGAGGCAAAACGATTGAAGAACTTTAAATGTGGGGTCCGAAATCTGAAAAATATTTTAAATTGACTCCAAAATTTCCCCTGACTCCGAAGATGCGAAAAAATTCAAAAAAAATTTTCCTGACTTTATATTTAAGCCTGAAATCGCCGAATTTCATTTAGAAATTCGCATTGGGGACAAGCGCACTTGCATGGTTCGATTTTTTTTCGTTTAGTTTATTTATTTTCGCCGAATTCAATGTTTTTGAAGCCATCATTGACCATTTTTGTCGAGTTCTCATGGAAAATTTTTTTGAGAGAAATTACATGAAACTGACTAAAAAATTAAATTCGGCGAAAATAAGTAAAATAAACGAAAATCTTCGCAAACTTGGATGCAAGCGCGCTCCAATGAGAGATTTCTTTGGGCGCTAGGTTGAAAAAATGGGGGCACGAATGAAATGTCGGCGATTTCAAGCTTATATATAAAATCAGGGAAATTTTTGAATTCTTTCGCGATATTCCGAACCAGGGAAAAATTTGAAATCAATTAAATATTTGGTTCAGGTTTCGGTACCCCGCCTTTAAAGGATTTTTTGGCTTAAAATTGGAAACTCTTGGTTAAAACTTGTAGAAGAGTAAAACTGTACACGTTTTAGACGATTCAAAAGTATCCAGGGAAGTATGCAGAAGTTGAAAAATTGCGAAAAACAAATAAGGCATTTTCTCAACGCGTGAATGCTTAGACTGAAAATAGTGTATTTCTTCCAATATATACGAAAATACGACTCGCACTGGTTTTCGATCGATATTTATAGGTGGAGTTGCTATGCATAACATTCCGGAAAAACACGAGATTTGAGGAATTTGAGCAACTGTAAAGCCAACAAAACATTTTGTACAATTTTCTTGTTGGTCTTCCTCAGAAAATTATCAATCAAAAACCAACTGACGCAGAAATCGATATATTCTGCTAGTTTTAAAAAAACACATGATTTTTAATCAAAAATTGTTAAAGTCATGCAATTTTCCTTCAATAGTTTTATACGAACTATTTTTTCTCTGGAATTCACATGCTTTAAAGCAAACGGCCGTTTCTCAAGCGGTTGTTGGCTTCCACGCGATGCCATAGAAACACTGGGGCACCAGAGAAACCGGGGTCGAAGCAAATGACCAAAACAACAGACGTATGTGAGCTTTCGTTTTCGTCTTCTCGAGGAACCACCACGCTGGGACTACAACTACGATTGATAACGAAAAAAAAATAGAAGAGATGATGATAGTTTTTGTAGCAATAAAAAGAGTGACAACAAGATACACTGTATCTCACCCACACCTTGCCGTACTTCTAACGCAGATAAGGAAACCTAGTAAGATTCGGGGGGTTCAAAGTGTTGGAGCCAAAAACGGAAGCCTTAACGGAGGGAGCAATTGTTCGTTGAACGAAGAATAAAAAACCATCATCTGCGTCTCAAAAATCACGAGATGTAAGTGAGCGGGTGGGTGAGTGAAAGTGCCGGGGAGTAAAACAAGTTATAAGACACAACGAGCGACGTTTGGCCGCTGCTGCGTTTCCTCACTCTCTCCTAGTGGGCGTGTGGGCACACTCACATGGAGCGCATGCAAGGGTGTATGCGCAAGTGGTACATCGACTCGGTATGAGAACAGAGCACAGTAGGAAGGAGCTCACGTGTTGCTCCACTACTCAGTGTTGCGTACCGTCTACCCATCTGTGGGCCACCGCGGTGCAAAGTACCGCACAGTGGAAGGAGGAGAGTTGAAAAATTGGTTTTTACATCTAGAACCTCGTTTTCCTCGGGATTTTGAAGAGAATTGGTTGACTTCTTGAATTTTAGTCGCGAAAAGCGCGGGAAAAGTCTAAAAAAGATGCGACGAGTGAATTTTAGGGCAAAAATGAACCGACACAAATTGCTTATGAGCAATCGGCTTCTCGATCGGAAAACATATCACAGAAAAATCGGAAAATCAGCAAAATTCGAAAATTATGCAATTTTCTAGAATTCCAAGCGAAATTTTCTAGAATTTGAGGCAAAATGATACGGAAACCAACGGGAAATCCAGAAGATAAAAAAATCTATCGTCGAATTCTAGGTAAAAAGCTCTGTGAATTACTCGATTCTCCGTCTCATGGGGTAGACTCAAAAATTATGCAATTTTACCTTTCTAGGCGAGACATCGCAGGATCGCCTACACAATTTCCGGAGAACGATGAATATCGGCAAATCTGAAGTAGGAGAAGGAAGAGGCTTCGGATCAGTTTTTCTGAAGAAAATACAAAACCTTCGCTTTCGCAAAACTTTCGGGAAAATTCTCAGAAAAGGCGCTAAATCAAAAGCTCAAAAAATCGACGTACGATTTGCGACGGAAAAAGCTATCGAGTAAAATATCCGAATTTCTGTTTAAAACTGGAAATTGCCCAAAAATCCGTTTGTTTTCGCCAAATTTCTCCTATTTGGCGGTCACAAGGCGAGCGGGAGCCGCCCGAGATGAAGAGCTCCACAGAGCCCCTGTGCCAACAACACACCGGTACACTCACCCAAACATATTGGAATTCTCCTGAAGGAAAACGTCAAGGGTACGACGACCGCGGCGGCGACGGTGCCATTTTTCATGGGGAAAAGAACCTTGATCGAATTTGTGATTTATTATAATCGAATTTCGCTTCTATGCCACCCCAATTACGTGACCCACCTGATTAGGTGCGCGAGTATTTCAGTGCGGTCGGCCGATCCCCCGAAAAATGGAGAAGTTGTCTGAAAAATGCGAAAATTCTATAAAACGACGGAAAAAGAAATGAAAACAAATAAAATGAGGCCGAAAAGGTGAATTAGTTTATGCAATTTTAGAAATGTGAAATTGTGGCGAGATCGAAAAAAATGCGAAAAACACGAAAACAGGTCGAAATTTCGCAAATTTTGAACGACGACTAAAATTCAAATGCACAACGTTCGCGCGTTCTCGCGCCGAAGTACGGTCGGTGAAGCCCGCATTTTTGCGCGCGCGAAATTCAAATTTTAATTTTTAATATTTTTTCTTTCTTCTTTTCTTTGATTTTTTAAGAATTGCAAAACGTTCAATTCGTTCATTTTTCGAATAAAATTGTTAAAAAAGACGAAAAAAAAAAGAAAAAATAAGACAAGTTATCGGTGCAAATAAATGCAAGTTATTGTTCGGGAAAAAAATCACAATTTTAAGTGCAAACAGATTTGTAATAAGATCAATCATTCTTTTATTTTCTTCCAAATCCCGACATGGTTTTGGGCAGCCGATCATGCAGCAGCGACCTCCACTCCCCCGAGACACGCCAACGACTCGCCGGTTGAGATGGCGAGAGGCACGAACCAAACGACCATGACCTGGAAGAAAGTGTGTGAATGTTAAGGTCTCTGAATATTCCAATAAAATTAATTGGTTTTTTTTTACCGGTGTTCTTGCCAGAAAAGCGCAAAAATTAATTAAAACTCTAATCGTGGCGAGACCCATCTTCTGAGAAACGAGGTAGGTATGCGCCTTTAAAATTGGGCTACCGTAATCGAATATTTGCATGCAATTGTTCTGATTTCCGAAGAGCGAACAAGAAAATTTGATAGAAATGACACATGAATTAGGTCATAAAATTTGCTTTTTTTTTAGATTCATATAATTCAGATCTCTATTTTGGACACGGAGTTCCATGACCTTCCTCATTGAATTTTTCGCGCTACATTGACAATGGCCTGCCGGAAACAACGTGGGAAAGTTGTGTCCTCCATGCACGGACAAATACATTTAGTATAACAACAAAAATCGAGACGCGACGCGACACGCAACGCGCCGTAAACCTACCACAGATATGGCCGAGCCCATAATGGCCTAGTTCGGCAAACTCTTCCATTACAATTGATCGATGTCAGAGTGTCACATTTCAGCTTGATCTACCTAGATCTACAAAAGCGGGAATCATACGTAGAGTTCTCAACTGCTTTCGCATGTTAAGTACGCTGACGTCACAATTTTTTGGCTAAAAATTCCCGATTTTTTTGTAGATCAAAAAACTGTGATGGGACAACCTGACACCACGTGATTTATGAAAAGCCGGAGAAATGTCATTTGGCGAGCACAAAAAATACGAAATTCGGCCACTGATTCGCGGCCACGAGCCAATGTGCCTTCACAAGACATTGCACAGTTAATAGGGTGATACCCACAAAGGTAAAGGCGCATGCTGAGCATGACTGGCCAATCTAATAGCATCTACATTGATAATTGAAAAAAGAACACACAATTCTGTTTGGCAACGTTTAGCGACGAGTGACATAATTCTCGGAAAGCTTCAGCTGAACAATTTGAGGGATTACTTAACTTCCTGTTTCCCATCGCTTCACCGTCTTAGATAGTGCCATTGCCGATTGGCAAAATGGGATCTGCCCCCAACTGCCAGTTGAATAGGATTGTCTCTCTGCGTCTATCGGTTCTCCAAGATCTTGCGGCGGTGAAGCCGTGTGTGTGGGAGTGTGGCTCCTTCATGCTAAAATGTGTAACACTGCGGGCAACGCATCCGATTGGTCGTGTTTGGCAGCGCACGGCGGGAAAACGAATCCGGATATACTACATACACAAACACACACTCACACACACCGAAGGAACGTTTCCGAGACACCTGAACTGGAGGACTTTTTATGATTTAAGTGTTTCTGCTGCCAGCAGGATGTGTGTGTGTTGTCAATAGGATATGCTATTTTAGTCCACATTAAAGTGATGAAACATCAAACCGGGTAACTTAGTCCACCCAACACTCTGTGAGCGATTAACCCTTTAAGAGTGCACTTGCACTTCTAGGCAGGATTCAATAGAATTGGGGCCTTGGAGCCTAGTCGACTTGCGATGTGAGAGGCAAGGTTGGCAGAGCTAGGATAAGCTTCTGTAAATGTAGGTCTGTAACAAGCAAGGATCTCGCTCTGGTACTGTAGCGAAATTTGAGATCAAATTAGGTTTTTCAATATTTCCAGTAACTGGCACTGTTTCCGGCCCAGATCTTAGAAAGAAAAGAAAAAAAGTATGTTAACCAAGGCGTGGGCGGCAAACGATTCCGGCAAATCGGCAAATCACTAAGTGAATTTAAAATTTCCGGGAAATCGAACTGACACTTTACGCCAATCTGCCGAACGATTAGCAATTGCCGCCCACACCTGATGGATACGTATATATGCTTTCACTCTTGTGGTGGCAGATGTATCACTGCGGTTTAATGAAAAATGTGGGAATATTTTTACAAACTTGCGGCGTCAGCACACCGCTCCAAACCACGCAAAATCAGATGAGATGTATGCGTCTCTTCCCGCAGATTTTTCGAGGATCACAGCAGAACTTTCTAACTCCACCTGTCTACTGAGAAAAGAGCCAAGAAAGCATATTTTCCTCGTATCAGGGATCGGAATCCCACGGCTAGCTAGTTGATCCTATTGCATCATTGAAGCATCTGATTCTCCACTTTGTTCGCTTTAAATCGTTTCAAACTGAAAGCGCTCTCAAGGCCGTCTTCCTCCGATTTTCCGATCATCCTACCTTTTGTTGATCAACACGTGCCCGGCGATCACAACACTGTTCAACCGGAATATCGTGTGAAGATGTTCCACCAAATGGATCGTTCGCTTTTTGGCTCAGGACGGAAGAATGTGTTACTAATTTCCATAAAGTCTGTTCTGTTCTAAAAGTTATGAATCTTCTGAAAAAATTTCAATCAGACTTAGATCCTGTCAATACATTCATGGGGAAAGCAGTGGAGTCGAAGATTTTTTATCAAAATATATGGCTACGTAGTCAGGGAGAGACTGGCTCCTTTGTTACAATATATTAGGTTTTGTTCCTTAAAATGTTCAAATGAAGCTGAAGATTGGCTAAAAGTATATGATTTTTCAATGATTTTTCAAAAATTTCAAGGTATAAATCTACGGAAACTAGTCAAATTTAAAAAAGAAACTAAATTCGATTTTGTTTGTTAGTTTGTTAACAGACAGAGCAGTTATTTTGATAATTGTAACCTGAACTCTATTTGTCTAGTTGACATCGTGAAGTAAGAATGTTTTAATGTGGCATTTATTGAAATTTAATTGTAATAGAATATTTTATTATCTAAAAAAATAGAATTGGATTATAATGTTAATTATTTTACTGTGGAAAAGATCAGTATTTTGTGATAGTTTTAACCTAAAGACATTTCTGAAGATCGTTTTTTGTGAGAAAAAATTATTATAATATGTGTCATTTAAAGCAAATTTTAAAAAAGTGCGGTCTAGAAATGTTCAACTATCAAAAAAAAGTACATTGGATTTTGGTGCCAGTCAATTTATCAACAGAAAAAGTTGAGGGTCCTAAAATAATTTCCAAACTTATTAATGCACGTGAGCATGAAAGCTAAACACTTTTTTGGGATTTTTTGCGCAAATGAATAGTGTATTTACAGAGACAATGGTAGATCAACTTAAAAGAACAAGAAATTTGCAATTTTTCCAGGTAGGACACTTTTTACTCGAATATAACTAACCTAAAATAATTTCCAAAAGTTTCAATGGTGGTAGCACAAAAAAAAACAATTTTTTTGATTTTTGAAATGAATGTAGTTACAAAGACGGTGGTACATTGACCCAACAAAAGTAACGAAATTTACTACTTTTGTCAGGTAGGAAACTTTTTTGCTACTCGAATATAACTAACCTAAAATAATTTCCAAACGTTTTTGTTGGTAGAATGTAAAATAACTTGTTCTTTTTTGGTTTTTTGAATAGTGTAGTTACAGAGACAATGGTACATTGGCCTGAACAAAAAATTTAGTTAGCTATTTCTCCATTTTGACCTATTGGTCCCCTACAAATTAGTAAAAGGACCCACAATCCAGTTATTTTTGTCGGTGTTTAAGCAGACTACAACCTTCGAATTATTTTCAGAACCAGATGTAAAGATTTTAGTTCGGTGCTGCAAAAACCATCAAAAAATACCAAATTTTTCGGCCTTTGTGAAGCACGGCAACGAGCAATTTTTGAGATCGTCTTTGCCAGCTGCACACCCCAGGTACAGAGACTCACTTTTATATCACGTGAACGAACAAAAAATTTGCAATTTTCTCACGTAGGCCACTTATTTACAGCTCTAATTTCACACACCTAAAATACAAATGTTCATCCTACCCATATATGTAGTAAGAATATTTCAAATTCAAATTTTCATGTACAAATCAACTCGTCGCCACCGTCTTATTGTTTCCCTGGATTTCCTGATCTGACCTTGTCACTCCACGTATGTTTGTCTTTGTGCCCACCTCTCGTGCTCACCTTGTTCCAAATTCTACCGTGAAAACTCATCTGAACGCCATTTTCGTATGTCCTATGAGTTTTTCGGATGCGAAACTTGGAAAAACGTCAGACAACTGCAAATGACCTCCCGGGCGTCGCTGAGAATCGGTGATAGCCTTGTACTGCTTAGATGAGACCAGATACAAAGTGCACAACAAAAAACAAATTCGCTTGAGAAGCGCTGGCGAGAGATTCGAAGCGAAAACGAGTTGATTGACAATCCGGAACATATAGACACACCAGAAGACAAAGTGGGGGAAGAAAGGAAACAAAAAAGATAGAGAGGAAGGAGATTTTGAAAAACGCCAATCTCTCTGTGTGTGGGCACTGGGTGACAGGTGAAAAAGTGAGAGTGAGAAAAACGTGGTGGGTACTGTATTGATGAACGATCCAAGTTGCATACTCAAATCTCGTTGATTGGCTTGTGTCCTGGTCGGTTTGATAGAAGGTGAAGTTGGATTTTGTTCACTGAATTATTGGATTTCGAGACATGAGCAAGCTAGGGTCAGGATGACTGTAGTGGCCGGCTAACATTCCGTACACCCTTTGGCCGACTGGTGCGTGCAACCAGGGCTAGTAAGGAGGTACATCCTGACCGTAAGCTTTTTAAAATTCTGAGAACACCCTACAAAAGATATTTGTAAAGTTCTCCAAGACAGGTGCTAAAACTTCTGGAAAGAGTAGCTTAGAGTCAGAATGTATTATTGCGATCTGATCTACAAAAAACGCGGGAGTTGAGACGCAGTATTAAGTCTATCTCATTTCGCATGTTTAAGGTAGCGTGCTGAACAATTTTTAACAAATATTTCCCGCATTGTTTGTAGATCAAACTGTAATGAGACAGCCTGGCACCACGTGGGTAGGTGTCGGGATGCACGTGGTGTCGGAGTGTCTCATTTCAGCTTGATCTACTAGATCAACAATCAGAAAACAATGCGGGAGACGAGACGCAGAGTTCTCAACTGATTGTGCATAGGTAAGCTCGCGCTGACGTCACATTTTTCTAGCAAAAAATTCCTTTTTGTAGATCAAACTGTAATGGGACCCCATGGCACCGTGGGGATGCATTAGTGATGTAGATAAACCTTGAACAATAAATATACATTAATTTCGTCATGCTTGAAACTTGGACCCAAAAACAACTATCTGTAACTAGAAATTCTACAAACAATGAGTTTGCGACTTAAAGCTGGAAGTATAAAAGTTGCGCAAAAAGAGACCTGTGGTCGGGCGCTACCACCATAAAATTTTAAATTTGCCGGTCCCCACACCTCGACATCAAACGTGCAAGCCGGGCAACTTGGTACATCTAGTTCACCAGCACTCCAACTAGCTTCCCAGAACGCTAAAAACATTGTTAAATTATTACTTGTTCAGTACATTTGTCGACTCGACACACCATCACCCCACCTAAACCCAATAAGGAAGTCGATATCTACTCATTTTAGGGACCTTTTTTGCCGCTTTTTATTGATTTGAACAAAAACTCAGCAGAGAAGTCAAAAATTGCCAATATCCAATTTTTCAGTTCCCAAAGATTGTGAGTTTCAATACCTACTAAATCCTCCCGTTCCGCCGTTCTTGATATTATCTCCATAAATGTCCGCTTATCTCCTCTCTTGTACTAAACTAACGTTCACTTATCCACATAATAAATACAATAAATGTATAATATACAAGAATAAATACTACACTATATATAATATATATATATATATATATATATATATAAGTATATAATATATATATGTATATCTATCAAAAAATCAAACAGGATCTCTATTTTCCTCCAGGAGAAAAAGACGATGTCAGGTTGTGCGCAACAATACTCTCACTCTCAATACCGCGACGACGTGGCATACCTCCCCCCATCCTGCCTTTCTTCCCCGTTTCTCCTGATCGAAATTTCCAGCAGCACACCGGAACTTCTTGGTTGGCATGTGAAGCCGACGTGGATCGTGACGGTGATGATGTGGCGGATTGTGATATGGCGGAATCGTGTTTTTTATCCGGCGAGTACTGCGAGAATTGTCTGAAAGAGTGGCACGGCGCCTGTGTTTCGGCTCTTTTCAGCATTTTGACGTGAATTTCATCCCCAAATTTCTTTTCTCATCTATCAATTTGAAAATAAATCAAAGAAATACAAAAGCTAAAGTTCACTCATGTTTTAGCACACGGCGCGAGAGGCGGAAATCGCCTTAAGGTCAGGCACAGAGCAGGCGTGTAATGCCTACATGGAAGCCTAGACTTCTCTGAAACTGGGTAATGTTGTTCCGAAGTGCAGTGCCTGAAATTATACAATGTTGTTCTAATTTTTCGGTGTATATCAAGCGCTTATATCCGTGTGTCCATAGTTGGTAGTCTATGTAGTCTCAAGTTTTGGCTTCTGGTAGGATAGTGAGTTGGGGTCAGTGTAGGGATATGGTCGGCGAAATGTAGTGGTACAATAGCGGTACGGTAGCAGTACTGTAAGATTATGGGACTCTCAGAAAAAAAAGTTTGCCACAGAAGTCGAGGTCCGTGCCGGAGGAGAACGGCTGGTTATCAATAAAGAATACCGACACTTTATGATATCACCGGTAAGCGCTAGACAATAAAAATTCGCATTCTGAGAAGGACGACTGTAGCAGTTTAGCGTGTGTCCGAGTAGATCTGGCGTCTCTTAATTTAAGTTGTAGTTTCCTGGTGTCCCCTGATCGCGAACTTCCCGAGGTAATTAGTAAATATTTTAGTGTGGCCTATGTTTACTGGTTTTACGGACTAGCCCGAGAAAAACTCTGGAACGAAAAAACCCAAATGGGGGCTCTTATCCAAGACTACCAAAGTTTCTATTCTATGCAATTCCCTAGTTTTGCATTTCCTCCGCCTAATAACGCATGTTGTTTACCGTCGACTATCCCAATGCTAAAATTTCGGAATCATGTGAAAATTTACCTGATCGAAAGTATACGGTAACCGTAACATTTGGAAGAGGAGAAAGGAATTCGTTGCAGCCTTGGCCCATTCTCCCCACAGGCATAATTCAAAAAAATATTTATCGCAGCAAGAGTGTGGATTTGCCACAACCCAGCGGGTTCTCCCATCCAGCATCTCTACCTTTGCGGAGGCAGACACTGAGGACCTTGATCTGCCGCCGCGTTCCGACAAATGTAATAGCAGCCCCCCGCGCGATAGCTTTTCACTATTTCTTCTCTTTCTGGCTACTGTGCTGCCTCCTCCTGCGCAAGGATGATGCTGCTAGGATGATACCCTAGAGATGACGGAACGATCCGATAATTATATTATTGATGGAGACTAGAGATGTGAGATAGTCCCGCAGCGAAGGAACCTGATCTTGTTACAGTCTTGGAACCCAGGAACAGCGGATAGCGTCGTCGTATTATCGTTATTCATTTCGTAAATAGATTTTCTCTAGGATTGATTCCCGGTTGAGCTACGTCACTGTCCGAGAACATTCCGGAATGTTATGTGCAGATGTTCTTTTAAATAACCTTTCTCCTTCCTCCCGCAACAACTTTCATTTCTATGCGTCGAGATACGATATCCAAGGCCACAATCAGTATCTTTTTTCGCTGCTGACTCTCTCTCTCTCTACTCGTAACCTTCGCCCATCTCGTCAATGGTTCAGAATCACCTACCGCAAAACAATTGAAAATAAGTGAGTGTGGAAGTCACGTCATGAGCGCCCAATAGATAGAAAGAGAGAGAGAGAGAGAAGTGCCGAAGACAGTGTCGGAATAGAAAAGTGGAACCAGCGGCTGGATCGTCATTTGTTGATGATTCCTCGTGCCTGCCATTGTTATTCGATATTCCGATATTCGATTCTTTATTGCCGCCCCCGCCTAAGAGCCCGTGAGAATCAGAACGAAGCTTGCGCGCTCCCTATTAAAAAAAAAAGATTATCAAATTTGAGCAGAAGCGGAAATGGAAATAATAGCGGATAACGTTACAAAAAGAGCGAAATGTTTTGGGCAATAAATTTGTAGTTTGATGATAAGAGTGGCATTTTGATATGAGGAAGCTTGCAGAATGTAGTGGTGAACAGGAAGCTTTCGCTATGGAGCAAAATGGATTCCGTCATTTTTAACTTAAAGAATCGGAGTCGAGATGAAACACCCAGCCGGGCTGAAAAATTATTCTGCTATCGAGGCATGCTTGAAAGTACCAGGGCCTTACACAAAAGATCAGGGATCCTAGTTCTGCAAAAAAAATTTCTGCATAATGAAATGGAGAACAGGGCGGTGCGGCAACCAAGAGTTTCGGCAACTTCGGCATTTGCCGAAGTTGCGGAACCCACAACATTTTGGTAACCGGCAATTGCTCTCGAAGTTGCCGAATTCAAAAAAGTTCGGCAACCGGCATTTCCGCGGGCGAAATCTCCAAATTCAAAAAATTTCGGTAACCGGTTGCCTCACAGCTCGGCTGGAGAAGCCGGTGGTCAGCTCATAAGAGTATGGTTCACCACAACCCAGAAATACCATCTTTCAGTGCCTTATACTGTAAAAACACTCTGGCTCAAAGTGCCCCAGAGGCCCTGGGATCTATCCTTACCCTGGAAAACTTGTGTGAAATTTCGAATATTCACAGCTACTAGGTTCGTAGCTCTAGCTCAATGTTCCCACTCTGCCTTCCACAGGACGTATTTCTACAATATTTTGCACAACTTGGTACAGTACTCAGCTTTCCCTTTTTGCACCAAAACATTATTGATCCTTACGATTAGCGTCCTAGATAGGCTACGCCATCGAGATCTCGAATATGCTAATTCTTAGGAAAGAGTGATGTTTCATCATCTCCTGGGATTAAAAATTTCGGAGGAAGAACATGGCAAAAATCAGGTTGATCGTGACACTCGTCGGGGGCTCCTCTCACTTCTTCCCCATCTTCATCTCTCCTTCTCTTTCCCGATCCGATCTTTTTTCCTTTCTTCCATTTTGTTTTTCCTTTCCATTTTTTCTTCCTTCTTGTGTTTGATTAGCCATCCTCCTTGGAGCCCTTTCACCTTGTTTCATTTTTCTTTATTCAGGATTGAATAGAGATATGGTTCCGTAAAATCAGTAATTCCAATACTAGAAGAATTAGTAAGACATTCGAAGGGGGGAAAATTCCGCGCAAAAATCGACAGGAGGTTCGTCCGGATTGGGTAATCGTCGGAGAAATGAAAAATCGCGCGCGCTCGCCCGCGCAGATGAGATATATTCTAAATCACATGGTCAGCGAAATGATCTACGATGGATTGCGTGATCTATAGGCGTATCAAGGAGATTAGCACTGCTGGGCGTCGGGATTCCTTGAAGGAACACGATCTTTGAAGGAGACGAGGAGGTTGTGAAATTTAATTGTGATATCATTCGATTATGTACTGGCCTAGAATATACATCATCTTTGAGAATTCTGGTCGGCTGTTTTCGGGAAGTTCTCAAGGATCGGCGCAGCCATGTCTGTAGGAAGTGCTTATGCCAACCCCAACACGTCACCTTCTCAATCTACTACTTAGAAGTTCAGTCCTGCCAATCCGCACGCTCCCACCACAATGTCTTCGTCGCCTATCCGTTTCTCCTGTCGAGTCTCGGGTCAAGGCAAGTGTGCGTGTGTCCCTTCAGTCGTCGAAGTCTTAATCATTTATTTTTGCTGCTAAAGTCCGAACAGTTTTTTCTAGCCGTGTCGGCGAAAGGGTTCTTATTGCGAATTCACCTCCTCCCACCCGAGAAATGGCCCCCCTGCCGCAAAACGTGACCTAGCATTAAATAAAAACAACACAAAGCGCCTCCTGCATCATCACGCGTATATATGTATTGTTGAAATATAAGATGGTAGGCGGGAAGAGGAAACGACGATCAAGATCGACTGAAGGTTGCGCAATCGAGATGGTCTCTTCCCGGCACGAATACCTCCTCCTCGTACAGCGTACCAGGCACCCGCATATAGCTAAAGTTCTCCGCCCATTTTTACTTTTTTGTGCTTTAACATCGCAGCAGCGCTTTTGCCATTGCGCCCGACCCGATCCAACTTCTTATTCTTGTTCCTCTACTCCCCCGCCCATGTCCTCCCGATATCAAAAAAGTGGGAGGAGCATGCATAGTGAGAGGGCGGGGCCGGGACACACACAAGGCTGGCTCAACCCGAGAAGAAGGAACAACAATTATGCCGAGGACAGTCTCGACAGGCGGCCCGACCTGCGCCTTGATTACCCCGCCCGTCCGCGTGCCCAGCCGTGCACGGCTATCTTGTTTGCCATTCATGTTCCTCATTCGACGTTCATCATGCTTCGGTTATGCTTCTTCGTGTTGGTCCGGTTTTTCTCTCTCTCTTCGGCCCTCTTTCTTCATTGGACCAGATGCCATTCGCCTTTTTGTCGCCTAGATAAGCGCATATTTCTCATCTCTTCTTTGTTTTCCATCATTCATTATATATCCAATATCCCACATCCTATATCCTCGTTCTCTAAGTCCCTCATTTTCATTCATATGCCGATCCATTTGGTACTGGTGGTGTCTTCTTAGTTTTGCTTTCCCATTCCTAGACAATTCCTTCTATTTCCACTTTTTTCTACACAATGCAGACAGCCCATCCCCACGCGCTGCCCTTGCTCTCTCCGATCTTCAGCCACAAACCGGCGCCTCGATCAACGTTCTCAATTGGCAGTGGATCAGGCAACTGGTAAGTCGAGTTCTTATGTAACTAGTAGGATGGTAGACATCGAGCTTAACGATGTCTGGCATTCGTTACGTACGGGTTCTCGCGCCGCCCATCGAAGCGCTTGAGCGCCGATTCACGGCTTTATCTCACCCCGGTCTAGCAAGTTTTCCAATCCATCCCAAATTACAGGACAAGCGGTGTTGGTGATGGAGTTAATGGTTACATGGACAAATGCGGAGGAATGTTCGGAAACAGCAGAAACAACGTGAGTTATAAAAACTGGGGGGGGGGGGGGGGGGGGAAGTGCTGTTATAGGCGTCCACAGGGACATTGAGAACCGCGTGATGAAGAGTACTTTTATCCGAATTAAATCATAGGCTAAACGAAAACAAGCATCAGGTTCTTGTGCTTTGCACATCGGAATATCCATCTCAATCAAAACGCGGGAAACACGAAAGCCTAAGCTGGACCAACTAGTGTTAAATGCTTAAATGCAACCCAAAAATGAACAGTCTATCACTTTCATCTTCCTGTAAATCAGAGAACCTGAAGCGCTGGCAATGCGCACACTTACAAAAAGTGAAAGCCGATATATCAAGCTTATCACCTAGCGGGACTTCGCCCATTGTCTCATTGTCTCTTGGCTATCCGTCCCACCCCCCCGGATCATCCGCCCCCTTTTATCACTCTCGAACAGTTTCGCGCGTTGATTCAAGGACCGATTCGCATTCGGCAGCAATAACCCGTCGTCCTGCAAGCTGCTTTTCATCGAACTTCGTCAGGCGGACTTTTTTCCAGTAGTTAATATGTGAGTTTTTTTTGTTTTTTTCTTCTCCGAGTTTTCTACAAGATCCATTAACATTTAGAATGAGATTCGGCAGCCGGTTTTCTTGATTCTAATCTCAATAATTATTTCCCAGTGTATATAGTGACACGGACAAGTTGCCCGATTGCGAGGAAATACCAAAAGTCTTGTGCTGTACCCACGTGTCTGATAATATGTCTGTCTGGTCGAGTTGTTTCACTGAGAAATACCCCCACAAATTGGAAAAATACGAGACGACCGATGAAGAGCCACCGATTCGACAAGAGCTCACTGCAAAGAAGCAGATGAAGCCAGCTAAGGCAACTAGCAACAGAGTTGTCGGAGCAGTGCTTGACGTAGACCATGAAGCCAAGGAGCAGTTCATCGACTCCAAGGATATCAGAAGAGCACCACGAGTCGGTCAAGCTTCTCAGCCAGGAGTACCCGATCACGAGGTCAACGACGGCGACCGCCGAGTGCGCAACCGAGAAGTCTCAGCCACCATTCTCACCATGCTTGTCCCGCAAGTCGGCTGACGAAGTCTTCCTCTCCTGCTGTCGCCAACAGGTTCCATGCAACTGTCACTGAGCCTCTACAGAGCATCGTAAGAACATGTCGCCGCTGAAACTTTGATCCAGGCGATCCAGCAAGAGCACTGATGAAGGTAAGAATAGTTCAATCTTCCTATTGAGTTTTTTTGAGTTTTTCCAAAATTAATTCTTTCAGTACTTCTCCAAATGCTCTACTGTGCGGCCAACCAAAACCGCGACAACCGCGCGTGCGCTGCTCCAACCTCGGCATGTCAAACGCGGAACTCGGCGTCGGCGATCGTTGCCTATGTGCAACATATCCCCGGCGGGAGACTGTGTAAGCCCTATGGAGAAGGAGGATCTCGTCTGCCGTCCAACTGGAACGTCGTGATTCATGTACTGTGCCAGAGGTGGTCTTCGTAACTTGGATCAACTAGACCATCATCCCCGTTCTCTTCTCCCGTAATAAGCTGGATCAGGTAATAATCAATCGCCGATCCTCGTCTTAATAATTTTCGCCCAATTTCCCATCTCGTCCCCCCTTTTCAACTCTACAACATTTCTCAGTGATATTCATCTGAACCGCCCGACATACATCAGTTCCTCATATTCCTAACAGGGTTAAACAAACCCATCCACACCGTCCCCCCACGTTTCTGAAGACCCCCCCCCCCCCCACTTAAGGACCCCAAGTCCTAGTTACTAAATGTGAAACATAATGGCGAGACTGCAATACTTGTCCCCTGAATCCATGTTATTTACATGATAATCTATGACATATACTTTTTTTTTAAAACACAAGCCCCCTTGAAAACGAACCTCATCATTGTATGTCAAACGGAACCTCTTATTACACGATTAATTGTTGAAGTTTAGCGAATAAATCAATCATTGCTCTCGTTGGGTCTATGCCCACAGCGAAATGACCCGGTGCAGAGATAGATAGTTAGAGGGTCATAGACATCCGGGACCCAATGGGGCCGCCCGCGGAAGAGACGATTTGTGTCGATTTACGAAATGATGACAACCAGGAAAATTTCGTATAGAATCGACACAAATCGTCTCTTCCGCGCGCCACGCCCCATCGGGTCTCGCGGTCGCTCTATAACTATCTACAGTCTCTGTACCGGTAATACTATTGCAGTAATCGCAGGTCTTAGCGATTTTTCATAGCTTCACGTATTTCTCGATTTCCTCATAAATTGAATTGGATGCCTAGTTTTTGCTGAACTAGGGGCCATTTCGGCTCGTCAGTATATGGTGGGGTAGATTTACGGCGCTTTGCGGTTCGATACAATTTAGTTGTAAAACTAAATGTATTTGTCCGTGTGGAAAGAAGTACACGATTCACATGCGTGGTCCGACAGGCATCAATAGAGCGCGAAAAATTCAATGAGGAAGGTCAGAACTCCGTGCAACTTTACTCGCGAACTCTGGTGCGTGTTATTGTCTTTATTCAGTTTTCTGAGACGTAATGAATATACTTTTTTACAGCAAAACTGGAAAACTGATACAAAAGTCTCCAGAAACTAGATATTGAAATTACAGTACACTTTAAAGGCGCACAAACCATTTTCACAGTAAACAAAAAGTTCGTGCCGAGACATTTCATCCAGATTCTCAGTTAAAATTTTACAACACTCATTTTTCCTTGAATATTTAATGAAGTAGGTTCGAATGGAAAAGAGAAGAAACCAAAAAGTGAAATTATTCTCAAAAACTTGATTCCCAAACCGGTATTTCGATTTGGCTATTTTCGACCAATTTCGGCAGAATTTTTTAGCAGAATTTTACAAATTTTTTAGAGTTAAAGCTTATTTTAATTATTTTTCTCTGAATTCACCTATATATGAATATCTTTGCTTTCGATGGATCTTCCTCAAAAGTACACATTAGTTTTATTTTTCTACAAAACTGTGCAAAGTTACGTCGTGGTGTTTGTGCCTCGGATTTAAAGAGAAATGGCATTTTTCAATCTTTTGTCGCAGTTTTTCTGCTTTTTTTTTCACCTGTTTTTTCGTAGTTTCCTAATAAAAAGATCGTCAAGTGTTTCCAGGGGTCATGGCTGGATTTGAAATTCAAAGAGTCGAGTCCAAATTCTTCGACTTGGACGACATATAATCGCCAAAGACTCCACGTCTTGAACATTTGAGATTGGTGATTTGAATCCAGGTCTGAAATCGCATTGAAGACCTAAAAATTCTAGTGATTTTCGTTCTGATTTTTTCCAGGAAATGTTGGGAGTTTTTCGAAGCCAACTCAAAATGCAGACGGATACGGCGTTGATGCTCCATACTTGCTGCTGGAATCCGTTAGGAGTTCATTGTCCGTGAGAAGTTATATTTGCCCCGAATTTTAATTTAGAATTCCAGATTGACCCCCAAAAGCTAGTGTGAACATGCGAAATGTCTTTCTGAACGCTGACAGCAAGAAATTGTATCTCTTGAGTCCGGCTTCGCAGCAACACTTTTACGGCAACGGGGTGCAGTCGTCTGCATGCATGAAGAGGGCGAAGGAATCCGGACGGCGCGCTGAGCCTTTTCCCGCACGCACATGCCTTGTACTCCACACTTACACCACTCAGGGCTTAGGAGGTATTAATTAATATAATAAAGCACTTATAAAATACAATTCCTGGTTTTTTTTTGTTGCAGAAATTGTGCTCAACTGCAACACATCTGCAAAGGAAAGGCGAGAAATTCGACAGCCTCTAGACAAAAGTGAGTTCCTGGAGGGTAAACGGTGCAAAGATTGATACTTGGCTGAGACAAGACAATACGTGCTCGAGCAAGAAGCAAGAGACTTTCGTTATAAACTTCAAATTTCTTATGCTTGAATCTAATTTTATTCTTTTTAAGTCGACTGCTCTGTGAATATAATTCAAATCCCCATTCTGTAATATTTATTTTCTACTTTTTTCACACTCATTTTTGTGTTGTATTGGTGTAATTAACCTGGTTTCATGACTTTTTTGCAAGGAAGTTTGTTGAAAACGCTGCTGCAAAATTTGCCAGCAAAAAATTTTGTTCAAGCCCGCTCCATCGCACAGTTTGAACGTCGCGGTTCGAAGTTAGATGTGCAGGTCATATAGCAGAGAAACACTCCCTTTTTTTCTCGAGAAGTTTCACCAATTTTGCGCGATCACCTATTTTTTTGCTTTTTTGGCCTAATTCTCAGATATTCCTCAAAAACTTGAAAATCCAATCTAGAATAAGTGGTAATGGGTATATTCTAGGATTGTGCAAAAGTTAGCTTGAATTGGAATCCTCGATTAAAGCTTTCCTACCAAGAAAAATGTGTGGATATTTTGTACAAGTTTTTCATCTTTTTTTAGTAATATTCTCTGTGAAACTCCTATGGTTTCTCTCAAAGTTGTAAACTTCATAAACGCTGTCAGGGTTACCAGATTAAACAATGACCGGGAGCAAGCACCTAAACTCACCAGAGGAGAAAAGTCAAGGAGGTTGGTAGTTCAACATCTAAAATATTTAAATTTCTATATTTCAGCCACAAGTTGACGTTTCGATTCCCGACAACGAGGCCGTCGAGCAAGCAGCTCACCGTGGAGCAAAGACGTCTGCCCGAGGCTGCTGGACTTGGAGATCAACAAGCAGGCCAAGCAAAGCCGCTCCGAGAAGAAGGCCCGCCCTTAAAGCTCTTACGTCTCCAAGCGCGGACTCGAGCAAGTGACTGGAGTCTCCCGTGTCTGCATTGCAAGTCGAAGAACACCTCTTCGTCATAAACAAGCCAGACGTGTTCAAGTAGCCCAGCATCTGACACATCATTTACTTCGGAGAAGCCAAGATCGATCAGCCAACACGCCCAGTTGTATTGAGAACTGAAGCCAACTCGTGAGACCCCACAACAAGACTGTCGAAGATGAAAAGTCGAGAATGAGGATGTTGAAGTAATTCAGTATCTTAATATTTATTACATTTGTACGGTTAAGGAGGTTTCCACCGGCATTGAGGAGAAGGACATCGAGCTTGTCATTTCCCAAGCCAACACCACCCGCAAAGGCCATCAGGGCGCTTAAGGAAACTGACAATGACATCGTCAATAGGGGCAAGCATCATGAGCCCTATCTTGTAGCTTGTTTCCTGATGACTGAGCTTGCAGATACTCTTGTTATCGTTGTATCTCTTGCTTATCCCGTTTTCCGTTCCAAGAAAACGTTTATTCTTTTTTAACCTTTTTGTTATGTTAAAAAACAATTGCATCTTCGATACGAATTGTACAACCTACCTTTTACAGAAAAGAACAATAAAATCGCTGTTTGTGTAAAACACCCCTCTATTGATCCAGAACTCTCACTTCTTACAATACTTTACTCGTATGACTGTGATTCATCTCACCTGCTATCACTTTATCATGACATTCAAGTTTATATCAACAGCAAGATACCATTGTGTGTATGTGAAAAATGCTATCGAATAGCAAGCGCGCCCCAACAAATTTGAATGCGCGGGCGAAATGGTGTTAGATGTGCAGTCATATGAAACGAAACGCATCGACCAGCAGCCAATGGGGTACAAGTTACTGCGAGCTGTTAGATTTTTTCACACGGTTTCCAGTGTTATCAGGTGATGGGAAATCGATCCATAATACTGACTATTCGTACTTAACATCTTAAACATCCCCACCGTTTCGCTGTCATTTTTACCGATGCGGATTTATATTTCCTTTCTCGCCGACTTTTCATTTCTAAATCTTCTCTGAAATTGCGAAATTTTCAGCCTGTTTCATACGAGATCGAACGGCTCGTAATGAACCATCATCTCAGCAGCCGTGTAGTACCGGGAGTAATGCATGAACTCCAGCAGAACAAAACGGGTCGGCAAAACCTTCAAAAGTCACAGTAAAAGGTAACAATTGATTTTTTGCATCTGTGCTAATAAAATTTCCCCCTCTTCCCTTAATCATAGTCGTCAACGCGCTAGTTCACCAAGGCAGCCGACTCAGCTATTGTCGAAATCACGGACACGTCATCGGCGGCGCCAAAAATGACGACTGCAAAGAAGAAGACGATGGCGCCCGAGTGGAAAGAACATCTCAACGTTCATGCAAATGAATCTTCGACAATTTCGTTTCGTCTATTGCAAACCGTAAAGCCAAGCTATGACACGTATCTAGGGATGGCGAAGCTGAAGCTCTAGTTTCGAGTCTCACAAGAAATGAGAATGGAGTAAGTGGTTTTTGTGACTGAAATTTTCTCAAAAAAGCTATTAGTTCAGTCAAAAACGACATCAACAATATATCTTTGCTGGCCAAAGACTCCTCGAAAATCGGAACTCACTCTCGACATAATTTTCTCCGGATATCCAGAGCGGAAACGAAGAAGCGCAGGAGTACGAACTGAAACCGCCGCGTCTCCAAGTTCAGAGGCAACGTCAAATGGCGTTGCCACGACATCCTCGGCGCGGACACCTGGCCGGCGTCAGCGAAGCGTGACACTTTGGCGGCTCCAACGGTACTCGTGACGAGACCCATTTTGAATAATTTAATTATTCATGAAACGCTCTACGGCAGTGTTAATAATTATTAGAGCGCGCTCGCGCGAAAGCACCTCACCCAGAAGTCGCGAGGACAGCAGTCTCTGGCTATATTGGCTGCTATGGAAATTATTATTTTTTGATTTAAACTATTGTTGAGAAGCATCATCCAAATTGAAAATGTGTAAAATTATGATTTGTCCGAAACCTGAAGGTTTTACAGAGGGGAGTCACCACGGCTTTCTTAAGTATCAGTACCGTCAATATTTCGAGTTCAGAAAAATATGTCATTTTGTAGAGAAACTCTGTTACTTCACAAAAATTTCCATGTTTGATATTTTAATTGTTTAATTTCTAATAAAATATTGCAAATTTAAATCAACAAGTATACGTTAAAACCGAACCTTTTTCAATCGTAACCTCAGTTTTTAATAAGAACACTTTCATAATTTCAAACATGGATTTGAAACAGACTTTTATCTACAAAAATGACATATTTTCCGACTCTGGAATCGAAAAAACTGACGGTACTGAAACATTTTAAAGAAACTCGTGGTGACTCAATCTCTCTGTATACCGTGGTTCACTTTTTGTTAAAAATATTTCCATCCAAAAATAGCCAAAAACTGCTGTCCCCTCCTGCGAAACGAAATCCCTCGAGTTCTGGAGTTCGTGAGGTACCGCGCGAGCGCGCTCTAACAATTATGAACACTAGAGGAGAACGTGAATGAGCGTTTTTTATTCTTTTCTCTGCTTAATGCTACAGAATCGTACACTAAATGTTGTCAAATACATGATGCATTACTCCAGTCTACTACTATATGTTTACTTTTCATTTGTACCGCAGCGGCGGCAGCCAACAGCATGCGGCACCCCGGCCGCCGCAGCAGAAGAGCTTCCCGATGGATGGGAGATGCGTTTCGATCAATACGGACGCAAGTACACCTGTACGTGGCTCACACCACCAAGAGCGCCACGTGGGAACGCGCGTCTTACTCATCCCTTACAGGGCGATGGGAAATCCGAAGAGATCCGAGAGGAAGAGTGAGTTTTCCGAGGCTGTAAAAGCAGATTACTTAGCACGAGAAAAGCGTTTCTGATTATATTTTCGATGCGAAAAGCATCAAAATTAAAACTATCTACCGTCGCCGCGGATACCTGGACCAAAATGCCGAAAAAAGTGACTAAATTATTTTATAAAATCTAGATTTTTACATAATTAGTGTTATTTGATGATTTCTTGTCAAATTTTTGTAATTGCATCGAAATAGTCCAAAAATAAAGTAAAAATCCACTTCCAACACAGAAGAACTGACAAAATTGAAGATTTTTGCTGAATTCAGGCAATTTTTCGTAATTATTATGATCCTACATAAGTTTTTGTTTTCGAGATATTCGAAAATTTTTTTCTTTAAATACGGCCTGAAAATTAGGAAATTATAACGACGGATAACGGTCAATTCTGATTTTCTTTATTTTAACCAAGGTCTCCGCAAATTATTTGATAATCGAAAATAAAAAAAAAACTTTCCAGTGATTTTTACTTGAGGGAAAAATGTCTAAAATTCACGCCAGGTGCACAATCCCTTTTCAGGTGTATTACGTGGATCAGAACACGCGCACGACCCCCTGGTGGCAACGACCGACAGCCGATATGACTTGAACCACACGAACAATGGCAATCGGGAAGAGATCAGGCGATGCTTTAATGGGAACAAAGTTTCCTTCTCCAGCAGATCAACTTTGCATCCACTCGTGACCATTGCCCGAAGGATGGGGCGTCAGGATCCGAATACGTCGAGATTGTACTTTGTGAATCATTTAAATAGGACACAATGGGAAGATTCGAGAACACAGGGGTATGTGAAAATTTTCAATTGTCCAACATTATTTCTATCAAAAATCACAGTTTTAATGTTTTAAAAGTTTCAGAGGCCCGACCAACCTTCAGGATGGTTTGGAAATGCGATTCACCGAGCAAGGGCGTTCGATTCTTCATCGATCACTACTCTAAAACCACCACCTAATAATGATCGAAGAAGCGGAAAACCCGTCGGCCCGCTCGCCGTCGTCGGTGTTCAAATGGCCATGGAGAAGAGTTTCCGGTGGAAAATTGCACAATTCAGATATTTATGCTTGGTAAGGGAGGGCGAGAAATTCTTTGCTTTTAGCTATAAATTGATGAAAATTTCAGTCAAACAGCGCCTAATCATGTCAAAATCACAGTATCCCGTAATAACGTGTTCGAAGACTCATTCCAAGAAATTATGCGTAAAAATGCAGTCGGTCTACTCCGGCGTCTGTACATTCAATTCCGAGGGGAAGAGGGTCTCGACTATAGAGGCGTCGCCAGAGATGTTAGGGTTCTTCCTGCCGCACGAAGTGTTGAATCCAATGTATGGGCTTTTCATGTATGCTGGCAATAACTATTATAGTCTTCAAATCAATCCACCTTCATTTGTTAACCCGGTCTTAAGTATTTCGAGTATATTGGAAGATTCATTGCCATGGTGAGTATTTTTTTTTGCAATTGTAAATCAGTTGAGAATTGGATGAAAAAATGCGATCGACATGGGGAAAAGCGAGTTTTCCGCTTTATACCATTGAATTTTAAAATTTTAAACGTTAAATTGAAAATTCAAACAAAAAGCACTTCTGGATCTAAAATTCTTATCGTTTTTTGAGGTCCTTAAATATCGATTTTTTATATTTTCAGCACAAAAAGAAATTTCGATGATCTCAAATTTTCAGATCAATATATTTCATTTTCTCGGGCCTAAAAATGTTATTTTTATTTAAACAAATAGTTTTTCTTAGAAAATTCCTTTACTTTCAAATTTCCAGGCGCTATTCCACGGAAAATTCATCTACAGCGGTTTCACGATGCCATTCTACAAAAAGATGCAACAAGAAGATTGTTTTAAAGGGCATTGAACAAATCGATTCGGAAATTTATAATTTATTGATGTGGAACCTCAAGGATAACTATATCGATGAATGCGATATGGAGCTCTATTTTGTTGCCGATAACGAGCTACTCGGCGAGCCCAAGACTTATGAGCTTACGGAGGGCGGTACAGAGATTGCTGTTACCAACGAGGAGAATAAGGTGAGACTTGGGATTAGCTAGAGCTTATAAAAATAATTTTTAAATAAAATAATTTAATTTAAAAAATCCCAATTTTCCAGCTTCAATCCATCGAACTGCTCGTTTGGCGCCGCTTCAATCGCGGTGTCGACCGCGAAGACAAAAGCCTATCTTCACCGGCTTCAACCCGGTCTACGCGTTGGAATGGATGGAGTATTTCGATGAAAGAGGCTGGAGCTCGAGCTGTTGCTCTGCGGAATGCGGGACGTTGATGTGGGATTGGCAGTAGAAATTCTGACTACAGACATTATGCTCCACAGAGCAAGCAGGTAGGGGAGAACATTTGATTAAAACCTTTATTTTTTTTTAATTAAAAAATACATTTATAGGTAACCCGGTTCTGGCTATGGGTTCGAAGACCAACCGTGAAAAACGTGCCCGGCTCCCACAATTCGTCACATCGCGGACCGTGCCGTGTGTCAGTCGGTGGATCCTGATTCGACGGGACCACAGCTATTCTGTATCGAGCGTATCGGCAAGGAGAACTGGCTCCACGGTCGCATATGTGCTTCAATCGACTCGGCTTGCCGCCATACAGAAGCTACGATCAGCTCGGTCGGGAGACGAGTTGAGGATGGCGATCGAGATGACGGAAGGATTTGGAAGCGAGTAGTCCATGTCCCGTTATTTTTTTTTGGTTACTTGCTGGCCGCACGTTCAAATTGTTGTCTAACCCTCATATTTCTTCCCACCTATTGAGGACCTTTTCCTTTTTTTTCTCTCCATCACTTAATGTTTCTTTTTTTCGAATCGATGTTGTGTGATAATTTTCGTGTAGTGATAGCACTTGTGCTTAGGTTCTCTCTGCCTCTCATTCCTTTCCTTCGCGTATGTCTACCTATAATGTTTTAGAATACTAGACAAATCGCATCTAGTTTTTTTATTTAATTTCCAAATTTCCCGTTTAATTCCAACAACAAAAAAACAATTCCACCTAGACACTTTTCAAATATTTTTGCGTCCATTGCTTCATTGCTTTTCTTCTTCTCAACCATTTCAACAACCACCACCCAATCTGCGCCTTATCCTCTTACTTGGTCACTTGTCATTCTTACAATTTTTTTCACGGAAGCAGCTCTAGATTATTAATTCAAATGCATCCCCCCAACCAATCCGTCACCCCCCGATTAGAACAATTTCTACTTTTTTTTTTGAAAACAAAAAAACACCTCGATTTGGTTGTAATCAATGGGAAATTTAATTTTTTAATCTGAGCCTTCTTTGTTGTTTTAGGGTTTCTTAACTTTCAGAATTTCCATGCGGAACACACGGAGAGCACAAGATCAAGATTTTGAACCCTGCAGGAGAACGGGACCCTTAGCGTGGTCACTCATGTCTCGGCTGTCTGTGGTTCTCTCCTCTCTCTCACCAGCGGAGAGGATGGATACCTCATTCGCTTTATTTTCGGACTTTCGATTTTTCTTATTGCTCCACGTCTTTTATCAGATTCGGGGAGCTTTTGCTTTTTTCTTGATTTTTTCGTAAAGTGTTCCTGGGTCCCGCAGCGAGAATTAACTTTAAAATGATTTTTTAAAAACTTTCAGTTAAAACTTCATTTTTTTTTCCCATCATTTTACGACTAGAAATTTCGAAATTTGAAAAAAAAAACCGTGTTGCAAATGCGCTCCAGCGTACAAAACGAAACCGCCACCAAAAGCTGATTTTAAATAACTGAAAAAAACGAGATGAAATTGAATTTGTTTTGCCATTTTCCGACAATGATTTTTTAAATAAAAAAAACTGTTGCACAACAAATGCGAGCGAACTAACCTACCAATTACCGAAAAAAATTATAAAAATTGAATATTTCCGATTAACCCAAGAAAAGAAAAATTCAATGATTTTCTTGAAAAAAGTTACCATTTTCTCAATTTTTCGTTAATAATACTCAAAATTAGACTTGAAGAAAAATTGTGTAGCAAGCGAGCTCTAGCGAACCAAACAAACTGCTTCTCTCCATTGAAGAGTTTCAGAGCCGAGGTTCTGGCCTACCTCATTGAATTTTTCGCGCTCCATTGACAATCGCCCGCCCATAACAGAGGGCGTGGGAAAGTCGTCTGGTACTCCACACGGACAAATACATTTAGTTTTACTACAAATATCGGGCCGCGACGCGACACACGCGCCGGTAAATCTACCCCAGATATGGCGAGCCAAAATGGCCTCGTTCGGCAAAAACTCTTCCAGCACTTTCAATGCATGAGAGACAGAAATCCGTGATACGAGAAAAAATAATCCCAAAAAGTTCAATTTGCAAGGGCGCTGCATTGAAAACGCGCCGATCCCAACTCACGGTCGAATTTGAATTTTTAGTTGCAAAAAAAATCCACCAAATTGTGAACTAAATAATTTTGCAATCAATTCTCTCCCTAAAATAAATGGTTCAGAGGAGTTTCTCGAATTCGTAGTTGATACCCGCTCGTCAGAATTGGAAACTGAGAAATTGAGAGAGAATTAGAGAAGGAGAGGAAGAAGAACTGCTCACTGGTCCCCTCACTCCCGGAAATTAGGGACTTTTTGCTCCGGCGGGCTCCCACTAGAAGACGAAGAAAAAACGACGAGCAGAACACAATCAATTTCTTCTTTTTTATTTTTTTTTGGATTTTTTTCTTGTTGATACCACGGATTTCTGGCTTCCCTCATAAATTGAAATGGTAGAGTTTTTGCCGAAATAGGCCATTCATTCGGCTCGGCCATATCTGGGGTAGACTAACGGCGCGTTGCGTGAGTCGCGTCGCGGGAGTTTAGTTGTAAACCTAAATGTGATTTGTCCATGTGGAGTACACGACTTTCCCGCGCGCTTTATGTCCTGCGGCCGATTGTCAAAGGAGCGCGAAGAATTAAATGAGGAAGGCCAGAATCCCGTGGTAAAACATGGTGCATCAACGCAAAAATTTTTCATCTTTTGGAAAAAGTCAATTGTTTTTTTTTCGCGTCGGGACCACCTAACCGCAGCTCGTTTAATTGAATTTCCCAAAAAAAAAAAATTTGCTCTGTTCAACCAAATTCGAAATTCAGTTTTCATTCCCTAAAACCTATTAAAACGATCGTGGCAAAATGCTGTGAGCTTTGGGGCTAGAACGATAGGCCTAGAAATGTTGAGACAGTTTCCTCTCCCAGCGCCCTTGCCAATATAGAAATTTCAAATTAGTATAGCTCGGCCATTTTCCATCCGCACGGTTTTCGCCAAAACTACACCCCATTATAAGATTTAAAACTTACTTTTCAATCATTATGATGATAATACTTATCCAGTGGAAAAATTTTATTTCCACCAAAACCTCTCCACCCGCCGTTTTATCAAACAAATGATATCACTATGATTTGTGTTGTAAGTGCACCATGTGATTGCACTTGCGCAATTAATTAAGACAATCTCAAATGTAAGTTTGATCGAATTAACCCCATGTACATATAAAATACAAGCTTTTTGTGTTCTTCAAACAGTTTTTTGTCGTATTTATATAGAAGCAGTGTACACCTAAATTTGGCTTATTATGACCTTTTTTTCCAAGGAATACTCATTTTTAGGGTTATAAACGGCCCTTGATTGAGGAGAGAACTGCAAGCGCTTTTTCCTGGGAGTTTTAGGCCACCAGTTAGAGTCTTGCAAAGACGGACTAGTTCTCACAGGACCCAGAAAGGCTTTACTTAGTCCATCACGAATTTCTGACGACGCCTAGAAATGCAAATCTTCGGCCACCTCATAGACATTCTAGGCCACCCTTTTTGACGTGGCCTAGAATCTTTAACAAAATTTACGTAATGAGAAGTAAATCCTAGGCTGTCCCACTATTCAGTTAGCTCTCATTTTTGATACTTCGCCTAGCGATTTTTAACACGTGGCCTAGATAGTTTCTATTTTAACACGGGGATTAGATTTTTATGTTAACAAGCTGGCCTAGGTTTGCTACTAGGCTTAGATTTTTTACATGTGAGCTAGATTTTTATTATAGCTGACCTAGATTGTTGGCATTTAGCCTAGATTTCTGTCATGTGACCTAGATTTTCTAATGCACCAAAAATTCTCCATACAAATTGATTAACTCCTACAACTCTAATTGAGGTAATCAGAACCTTCGATAAGAACATGGAGCTACTGCGGTTCTCAACTTCCGAAAAAGCGGCTGAAAAACTGAGGTATACCTGCTTTTTTCGAAACTGATAAAAGTCAGCATAACTCACGATAACTGAACGTCCCTTGGCCAGGTTGTAGGGGGTAGTGGTGGCCGAATTTTAGGTAGAAAAAACTGGGCCACGAGGTTTACGTGGTGTAAAATGTGCCCCATTTACTATTGGTTTGACCTTCGAAAAATCCAGGAGACGAGACGCAGACTTTGCTTCAGCTGATTTCGCATGGTTAAGAACGTGCTGATGTCATTTTTTTCCGTGGCAAAATTCCCGCATTTTTTGTATATCAAACCACAACGAGACACTCTAACATGAACCACCGTCCGGCCTCAAACGAAAATCTCGGCCACGGCCACTAGGGTGAAGTGGAATGCCCTCCCCTTCTCTAGAAAATTCATTGGAGAAATCAACCCATGCTCAAAGAAACAGTGGCCGAGAAACGAAAAACTAGGCCGCGTTCTAGCAGCTTTGTACCTCTCTTATAAAACACTGTCTGTTAGTTCATAAATCAGAATCTGCGCCCTATCACTACTCTCTCGTTTACCTGCCCCTCTTAAAAAACAATCAACCCCCCCCCCCCCTCTAAATCGACTACTGTTCCCCGTTGTACCTGTCTGCGGCTAGCTATTTCGGATTTTTGGAACGAAAAAGTGGTATGTGAGAATGTACGAAACAAAGCAAACTAATAAGAGGGTCAATTGTATGCATTTTTTGCCCCCCCCCCCCCCCCCCTCCACCCCGCTAGCCTGGGAGGTCTCAAACCGGTTTCCCCTTTTTCACCTCAATCAGCCCCCCCCACCCCCCCCCCCCCCCCAATTTCATTTCACTGTACATTTTCCTTAACCTATCTGCGTATCTACTTTTGTATTTGTTCCTTACTTATTTTTCTAATTATAAACCCTGCAATTTGCAAGAAAAATTCTAAAACCCTAGTCTGGCCCCTTACCCCGTACGGGACCGTGGCCGAGAAATTTATATTTCTTATAAGACCCCCCGGCTCTTCCAGTTTTTCATTTTTTTTCATTGAAAGCCTAAATTTTCATATTTTCTTAGAGATCAAAATATTATGGGTTTGTCAAAAATTTCGAAACAACAAGCTCCCCGTGGGCGGAAGAGTTTTCCAAATTTCTATACTTAGGCGTTGGGGTACGCTCGTCGCACCCTCCCGGAGTACAATTGTAAATTATAAAATTATCATAAAATTGGCTCAACGCATTTGAAAATAATAAAAAAAACTTTAGAAAAAAAAACACGAAAAAAACCCCTTTGAACATGGTTCATCGACCGGGACATATGTACTGTGAAAGCTTATATCTCTGCGCTCCATGTTTGTTTCATTAAATTTTTCAACCAACTAAGTGTTTATTATCTCTTTTCTATATTTTTGTAATTAAAAAGCTTTTTGATACTTCAAAAGTAACTGAGATGCATGTTGTGAAACAGAGCAAACTTTCCTAGCTTAGCCCAATTATTTATATCTGTGTTTCGTGTATAAACTTTTCTAAAAGTTTACGGTTTTTTTAAATTTCTAAATAAAATTATTACATGACTCTTTGGGAGGTCATGCGTTGTAGATAGCATGTACAAATAAAACTGAGGAACTAGGACGAACTGAGAAATTCCTAAACCATTATTTACACATGTGATTCTTGCCTTTTTCGGTGGAGGGTTAAAAAGGTTAAAAATTATTTAAGGCTTGGAATGAGCATTTGTGCGGCCGAGGTTCCTTTTTATTTTCTAGGCCATAATTTTTACAACAATGGCCAGAAGCACAAATTTGTAAGTAATTTGAATTCGCCAAAATTTTTTTTTCCATAAAATTTAAATTTCCACCGTGGAAAATTCTTTTCGGAAAATTTGTATTTCCCGCCCTCAAAAGATTTTTTGTCTCAAAAAATTGAATTTCCCGCCAAAATGTTTTCGTCGCTCAGGAAAAAATTTCCCGCCATCAAACATTTTTTGTCTCAAAAAATTTGAATTTCGCCCACCAAAAATTTTGTCCCAAATTTTATCGAATTGGTGGAAAGCCGAATTTCCATTTTCTAGGACACTCTCAGTTAAGTCATCAAATAAGTTGACTTAAATTAAAATTAACAATTTGTCTCCTACCATGAAAATTTAATAATAGGCTGTATAGAGCATCATGGGCGGGCGGGGTAGCATGAGTGAACTTACCGGTTGACCGTCTATACATAGTAACACCCGACCATTTTCTGCCAAATACATATAATATCGCTTCGAGACCCAACTAATGCGCAGTTGTGCTTTATTTCGGTTGACAAGACCCGTAGAAATATTAATTTACCTACAGGTGCTAGAGCGTTTTAAGACCTAAAAAACTAAGCAATGGCCCAAAAATCCAAACTTAAGAAGCGCCTATAATTGTGCCTCGTGTTCGGGACCCAAAATCCAACTAGGCCATATTGTGAGCTTGGTGAGACCCACCTGTCATAAATATCACTTGAGTCAAAGTGAAGCTCCTACTTTTTTTTTTCGACAGCCTGTAGAAAAAATATTGAGATTCGCAAAGAATTCACGGCTCCCCCTTTCAATGTTTACATACACATTACGAACGAGAAAACGAAAAAGCGAAACGAGAGAAAAGCATTGAGTGAAATGGAAAATGTGTTTTTACTTTTTATGAAAATTTAATCACATGGCGTAAGAGTGTCCCATTTCTGCTTGACGTAGATCTACAAAAAATGCACGTGGGTGAAGAGACGCCGAGTTTTCAACTGATTTCGCTTTTTTTTGGGCGAAAATTTTCGCATTGCTTGTAGATCAACTAGAAACGCAACAGTGGATAAGCGCGCTCTATCGACAAACCCGGTGTACTCGCGGACAACCAGTATAGTTTGAAATTTTATTTGAATTTTTGTTCGAAATTGAAATTGAAAAACGGTAGATGCCAAATTTAAATTTAAAAAATAACAATTTTTGGAATTTAATTTTTAAAAAAGTTCCCCGTAAATCTACACTTAAATCGTCTCGTAATTCGACAACGCTATTTTTTTCAATTGTTTTGCCCATCGCCAAACTTTTTTTGCCCAATCAAGCATCGTCAATTGATCCATTGATCTTCTTCTTCTTCTCTTTCTCTTTTCTCACCACCGAAAATTTTCATTTTATTTTTTGAGCACAATACTCACCTGTCTGCGTCTCTCTGTACCCCCGATCTCTCGCCTCTCAAGTATTACAAACGAAAAATTTGGGGAGAAGCCGTGATTTTCATTTTAGTAGGATATGAAAAATTCTAGTGAAAATGTCAATAAAAAAAACATTGTTTTTCAAAAAACAATCCCCTCGAAAATCCACACCAAATTCAATATTCACCTTATTACAAATTGATTATTTCTCCCAAAAAACACACGCCATCGGCCGCGCCAGGGCATCTATTGTCGCCTTTTTACTCCAAAAAATTTCTGCAACTGTCTGGCGTCACCGGTTAACACTGAGAAACAACAAATTTCATTTCTCGAATAACATTCATTTTGAAGGTTTTTGGTTACAAATTCGACACGGATTTCTGGCTTCCCTCATAATTTAAAATGGAAGAGTTTGCTGATGAACTAGGCCAACATGTCGGCCATATTTGGCATAGGTATTTACGGCGCGTTATGCGTGCCGCGTCCCTCGATTTTAGTTGTAAAAATGTGAAGTGTCCTCGTCGTGGAGTACACGACTTTCCCACGTGCCCGGTGAGAGATTATCAATGGCAATCATTCAATGAGGTAGGTCAGAACGCCTTCGAAGAAAATCGAGAAAAACATATCCACAACGATACTCCGCAAGGTGTGCGTGTTGTTAAATGATAAATTCAAAGCAAATAGCGATTTTGTTTCCAAAATATGCCGAAAAAAAGGAAAAAAAATAAAAATAAAAGTTCAGCAACTTATTTCTCGGCCGTGGTTGTGTCGTTGTTTATTTTTTTGCGATCGTATTTTTTCTAGAATAAGACTTAAAATGAAAAAACATGAATAAAAATCAGTTCTCCATGGCCACTGTCAAAAGTCGCAACGACACTCCCCTTCCAGCTCCCCCCCGCGTGTATTCTTAGCATGTGTAAATTACGCGATGTAGTGTATAAAACCCTAATTTTTTAGAAGATTTGAGAAAAAAAACTTTTAAAATATGGGATAAAATCTCCTTTCCCTTTTTTGAAATCAAGAACTATCCGACAAAAAGTTTAGCCAAAAGTCCAAATAAAACCAATATGTAGAAAAAATCAAAAACTCGGCCCTCCAAAAAACTAGGCTACACGTTGTTTCGACCTCGCCGTGCTCCCCACACCTATGCATATCGTTAAATGTCTCCCGGACCCCTCATTCCGTCACACATTTCTCAAAGTGTCTTTTTCTCAAATTCGCTGTCGAAAATCCCTGAACATATCTCTTCAGTGTTGAGAACGACCTGACAGTTTTATTTCGATTCTCATGATCTCAGTGTCTCCCGGATGACTCGAATTCCTTCGATATATTTTTCTTTGAAGTTTTCAAAATAATTTTTCCTATATATAGACTTGATTGTTCGGTGGGAATTTCTCATTTCAAAATATTTATTGAGGTCGCTTCCCTTTTTATATGGTCGTTAGGTTTCTAAAACTCGGCTTTCCAAGTTGTAGCTTAGAGCTCTTTGTCTCGGAGTATAAAAAATTCACAAAATAAATAAAAGTTCACGTGGCCGTGGCCTAGATTTCCAAACTCGGCCACCATTTTTTTCTCTGACAGTAATCCACTTAGATCTCCTTTTTAGCCATTTTTTAACTAAATTTCCCACATATTCGTCCGTGGCTCCATATCAATTTTACTGATAGTAATTTCCAATAAGGTATTTTCGGGAAGATAGGAACCCTTTTTCATCTAATTCGTTTGTTTCTACTTTATCGGTTTTGCCACTTTCCCGCATGCCTACGAGCCTACATATCTGCCGACCTAATACAGCTCGTAGGCAGACCTCGGCCGCCTTGTGGTGAGATGAGTCGCTTTGTAGGCAGGCGTAGTGTGTGTCTTGCTGGTATGAGTAGGGCCTGTCAGCCGCCCAGTAGGCAAGCGTAGGCATGCAGCCGTAGCAGGCTTCTTAACTAGGCATCTAGGCTGCCTTGTAAGCCGGCGCAGGTAAGTGAAGGTTTCCTCGTGGCTGGCATCCTTGCAGTCAGGCACAAGTCGTCGGCTTGAAGGCAGGAAGAACATGCCGCCTAGTAGGCATATTTTACTTATAGGCCCGAGGTATTAATGAGATCTAGGCTTGCGGGTTAGTCGGTTTGTAAGCTGTCGTAGGCTGCCCTGTAGGCAGATTGAACTCTCAAACCAAACAACACAAAAATTCCAATATTTTTTGTACCTTCTGATTTTGATCTCTGACTCACTTGATCTTACTTTATCAATCAAGAGTCATAACTTCCATTTTTAGGAATAAACAATTATCCTTCAATTCATTGACGTTAATCCCTTTCAATATTCATTCAATACACAATGAGACGAAAAACTCTTATCTTTTTTCACTCTATCACATGGTGCAAAATTATAGTTAGATTGAAAAAGCTCATTTTATCATTTGTCACTTTTCCACCACTCTCAACGTGCTTTTTTTTAAACACAAAACGTTTCCCGTCATTTTCTACAGTACTCCCGCATTTTCACATTTTCCAGGTGACACCTGAGATGGAGGCCGACGAGTTTCAACGTTCGTATTACGGTCCTCTCAACGACGGCTTCTGCCACGTCACGGCCGCGACACAAGACTTTTGAGCTGTTGGGACCGGTGAATAATATCTGGCTGATATGTGTATAAAGTGTAAGATAATTGGCAGCCCGATTGCATTTATTATTGCGACGGTGATCATGTGCAGTGGTGGATCGTTAGTTTTTTTTGACGTAAAAGATAGTATAAGCGTCTTTTTTTAGATCAACCGAAAAAGAAATATGGAAAAAACGACATTTAAAGATTTTTTAGAAATCAAAAAATGTATAAACTGTATGTTGCTTAGGGCCTCCATGGTAGACAGGCACGGTTTTAGGGCCTGACGTGCGCCTGCCTGAGACCCACGTGGAGTCAGAAAGTCCCATTTCGCTTTGATCTTCAAAAAATGCGGGAGAAGAGACGCAGATATCTCATCTATTTCTGCATGGTCATTTAAGCGCAGACGTCACAATTTTTCTAAAATAATCCCGCATTTTTCGCCACGTAGAAACCGCAAGGAGACAGCCTGACAGCTATTAAGCCAAAGGCAAAAGTGTTTGGCCGTCTGACTTTTGAAACAAAAGGCTCGGTGAAAATTGAAAAAAAGTCTAATAATAATTAATATAAAAGTAGAACTATTTTCAGTAAAGGCCAAATGATTGTTTTATAAAAAGACTTAATTTAATTAAGCCCAATTAGATCTCCTAAATGTTTCAAGCAGCACAACTTTGCATGTGACGTCAGGCTGTCTCATTACAGTTTACAGAAACCGCGGGAATTTTTGTGCTCCCAGGAAAATGTGCCATCAGCACACAATGCATAATCAGATGAGATTTCAGCGCCTCAACTCCCGCATTTTTTGTAGATCAATCTAAAACAAGACTCTCTGACACCACGTGAATTTTCCAACCATCAAACTATCAACAAATTCGCGCCAAAAAAACTTCTTTAAAAACTTATCATTCCCAGTGGGAACAATCGGTCTCGAACTGAGGGATAATCTGCGACGGGTACACGCCAAAAAACTTCCCGACTGGAAAATCGCCTTTATCGAGAGTTCCTGAGTTCCGAAGGTGATCCGGTGATGACTACAGTTCTCATCATGACTGCCAAAGACGGAGGATCCATGGATCGGACCAAGTATTTGGAAGTAGCGGGTGAGTGGCATAACATATCTGATACCGTATTTCCTCCATTAGTAAGGCATGCAAAACTGATTTTCGGACACCCAATTTGCTTGCAAAACTAATAGGTGCAAAATTTTCGAACAGGTTCTTTCTCATTAAGTTATATATTATCATCAATTTCAATATCAACTTCTTAGGAACCAAAATGCGCGAATGTTACGACTGATACGCAAAAATTGTCCGAGTGTACTCATATTTAGCCTTGACCTGTTATACTCAAGAGCCGTCTGTAAGAGTTTTCCTACAGAACGATTTAATAGTGCAAATTTTGAATCTAAACTTAGGGAACAAACTCGTTAAGGGGTGGAAAAATATTAGAGGTGCAAAACTAATAGAGAGTGGAAAACTAATTTTCGATTAGTGATTTTTGATGCAACTAATGGAGGTGCAAAACTAATTGAGGTGACTAACTAATAGAGGAAATCGACGGTATATTTTTTTGGAATAAAAAATTTCAGCAATGGCTACTGCTACATCTCCAAAAACCTATCCGCACGTGGCCGGTGGAAACGGCAAGTTCATGGAATTCGAGATTTCGTTGTGGCCACTACTGCCAAGCCATTGCAACGACATCATAGGATACCTGGACGCCTAGAAAACCAAGTCAGCTAACCCAAAAATTGATGGCTACCAACTCTATCACCGATTACCAGAGTAATGGGTTATCAGCTTCATCTCGAGCGATCCGGGGTTACTGTGAATCAGTCGGATCCGGTCACTAATATTCAGAGTATGAAGGTAGTTCTGACGCTTCCTGTGTTGTCAGAGGTACGGACGATAGAGGATATCGTACGGATAATCTGAACAAGTGGGAGCTGGCGGTTTATAACTATGCTACAGGATACTCTGCACTCCGGAGGGTGACGATCATTTGGTGGAGATTAATGTGAGTGGCGAGAATAAATTGGACCATAAATTGGGCCAGCCCTAAAAAGACAGCGGGCCGGCCCATACCGACCCACTTAAGGTCAATAAAGTTTAATTCAGGTGTGTGCCGCAAATTTTGACTAGAATTTGCTCGGCAAAATCGGCTTTGGTAATCGCATAATTTCTCGCTCGGCAAATTCGACAAGATTGAGATTTTGCCGTTTTCGGCAAACGGCGAATTTGGCAAATTTGCGCTTACACCCCTGGTTTAGGGGTTTCACCGTGTTTAATTTTCAAAGCTTATAAACCTCTTTTCCAGGTGATCGGAAGTCGTCGACACCGAAATGAACAAGGACGCTCAGAAAATGGTGCCCAGTCCTACTTCATTGTCGGAATCGTCTCGATGATCATCTTTATCTTCTGCACCGTATCGTCTCCCTCTGCCTGCTACAGCAGTTCTAACGGATACTTCTCCAGTCGATCGGACTCATCGCCCTCGCCTGCCTTTGCCGATTCTCGCAATTCTCACTGCATTCGGAATCAATAATATGCTGGGAAATCGAACGAACTCTCCGATGATGATCATTCCGTCCTTGATCAATGGAATCAGAGTCAACGATGCGTTTTTGACACCCAGTTCAATTGGTTGCAGCATAGCACCCGGATTTTCCGTCAGGGAAGCGGTTGGCGTATCTGTTGGCTGAAGCTGGTCCATCGACGACTCACTACGACCACTTTGACAAATCTAATTGTATTTTTGATCGGGTGTATGAACCCAACGGAGGGAAAGGTGTGGTGGACGGCAAACTACTTTTTCCGGCAGCGTTAATCGGTAAATAGGTAAATTGCCGGAATTGAAATTTCTGGCATATCGAACCGGCAATTTGTCGATTTGCCGAATTTGCCGGATAGCGAATAAAAAATTGCCCAACAGCACCTGCGCCCTGTTAAGGAGCTTTGGCCTCTAACATAAATTTGTCTATTCATCCTTAATTCCCTCGTAAAACGACAAGATGTATTCCAGGGATGACGATCTTCTGCCTTGTGCAATCTCCCTACTCCTCGCCGTCTACACCCTCACGTTCTTCTGTCCGGTGCTAGTTCTTCTGCTTAGCGAACGCGTCAATACACGAGCCCAGCTGGAAGCTCGAGGGCACTTTCAGGTTCTCGGATTCTACAAAAATCATATGCAGCCGATGGACATTTGCACTTCTCATCATCGGAAGTCTTGTCTAGTGGGGTTTCCGTATCTATGGAACACTGGGGATCCGCGCCGGTGTTGAACACTGCAAAGATCCTTCCCCTGGAGACGCCGATCCGACCGAACTATCGAGGAGACCGTGTGAAAGCGTTAGGTCAACCCAGTCACCGTGATTGAGAACAGCCAAGTTGATATAGGCAATGCAAAGGCTTCGAGCATTTGACAACCTCGTTGCCATCGACTTCTATGCAAAAGTGCCGGGGATCCGAGTACACCATATCTCCAATCAGAGACTCTACCATCAGATCTTACGGTGGAGGAGCCGTGGACTTTGATTATGAGGAAGAAAGCGTGAAAAACACTTCACATTCCCCTTTAGACTCCAGTAAGATAGCCGTCCACGCGTTCCTATTAAAATCTACATATATGCCTATAACGTGGTTATAGAAGAAAAATAAAACGCCATAACCTTCTGCCGCGCAAATGAATCCGCGGGAAGAGACAAAACTACTGTAGTTTTTAACCAATTTGTGTAGGCATTTACGAGCTATTGCGTCATCGGTTGTATTTAATTTTGACAATTACTTTTAATTTTCAGCGTTTCACTCGTTTTTATATTGAAATCTTTTGTCGGTATTGAATAAATCTTAAAAGAAAACACAAAAAAATTAGAAAAATTCCGAAAAAAGCCTGAAAATTAAAAATTGCGGCTTACAAACTTAAAGTCAACGATGACGCAACTAAAAGCTCGTAAATCTACACAAATTGGTTAGAAACTACAGTAGTCTCTTCCCGAGGTTTCATTTGCGCGGATGGCGATTTTTCTCATGGATCACACACGTAATCGGCACCTACATATTTTGTGTGCCTAAAAACACGGTCATCCTAGCAGTGAAAGCAGACAAATGTAAGCACTTAACAAACGTGAGTAGGGCTTAAATGGTATGCACTGTTTTAGGGCCGCCTGTCCAGGCCTGTCTTGTACGTTTCAGCAATTCAAGCCGTATCTTTCCAGAGAGCTAGTGTCACCCATTGCCAGCTAACCCTATCTACAAGCATCACAAGGGAGGACTAAAACTTAACTTTTCAAATCCGTTAGTTTCAATCTGCCAGCCCCCTGACCCTAAATCGAGTCTACCATTTTCAGTGATCCAATCCGAAAAGTACAACTGATATCCGCGCTTTTATGAAAACGTAACCTTGTGGGATGAACGGATTTATGCAGGACTGGCGGACCAATAATCGCAAGTTCCCACGTGGCCCTAAATGTTTCAGTGTGGTTCTAATGTGAACGCAATGTGTCGTAGATCAGATGCTGAGTCTGGTTGGCGATCACGGTAAGATCTCAATGGTTCCAGCGCCCTATAAATACCGCTTATTCTTTCAGAATGCCCTAGTCACCTTGGGATGTATGGCTGCCTTCTGGGTAGTCTTCATCCGCAACCCCCTCTCAGTTGGCCTAGCGACCGCTTCGATTTTATCCATCTCCAAGTAACTGGATACCGGTGCTTCTGGGACTTGGATCTGGACCCTGTGACCCTCTGCGCAGTAATTTTTTCTTGGATGTCCGTTTATGAGACTTTGTTGCCCATGTGGACTCCTGTCTCTATCAGGTCAGGTATGAAGATTTCGAGGAGAAAGGAGTATTGAAGAGGATTGAGATGAAAACTCCCGAATCTTGAGTCGTCAACTCGCTGTCCAATTTGTGTTCCCTGGCCAATGGTCCAGTCGGCGTCTTCAACTCGTCTATGTGTCCTCCACCTTGGTATTCTACTGGTACCTACGAATACCTATACTTTACCGATAACCCTACCCCTCAAACCTTCCGGAACTATCTCCCAATGGTATTCGTGAAAACCATCCTGCTTACGTCGTGATTTGGACTGGGGAATGTTCCACGGTCTCGCGCTGCTCCCGTGCTCAATTCCTGGATTTTCCCCTGTCAGTGTTCAACCAGACGTTCGCCGACTTGTTGTTCGGCAGAACATCCTCTCTCGTCTTGCTCTTCGGATTCCGGAAACCGACACTGGTGATGCTCAGGAGATGGTACCGCTCGCTGGAACCGAGAAGCCTTAAGACCTGAAATTAGTTGTTGTTTGTTATTATGTACAGTTGGGATACAAAGTGTATTATGTAGTCTGTAGTGTCGCAGTGATAGAAACTACAAATTCAAAGCTACAAACTATAAGCTTTGAGATCTGGCAGAGCTTTATAGTTTGTAGTTTTATTGTAGCAGCTACAAACTACAAATTTCTTTTGATGGCGCACAAACTACAATGTACATTTTGCCAGTTTTCTAGATTTTTTCACTCACACACACACACACACACCGTTTTGCTACGTGGCTGCGAAAATGCAAAACTCGGCCAGGTCGCAAACATCGCCAGAAACTTCTAGCTTTACCAGTAGCTTTTCATGATCTAGTCTTCTTTTTTTTCCCCCCTCAATTTATATTTTTCTCGAAATTTCAGAACGGTTCCCTAGTCTTCTGTCACCGTGTCCTGCCCTCCCGCAAGCGGGTCCCCTTTTCCCCCCACAGATCGTACGGCTTCTCAGGGTTCCTATAGCACTTTTTTCTTCGATTCGTGCCATACAAAAAATTATACTTCCCATCGCACGCCGTGTCCATTTTGTCTTGTACTTTTTAAATGCATTTTTTGATAAATTTGATTTTTTATATCATCCAGAAAAGGGGCAAAAATTCAGATTTTCCTGGCGAGTAATTTTGCTGGAATTTTTTCAAGCATCAGACATGCAAAAACTAAAACGACACAACACTATCGATGGGGATTCGACTCGTTCACCCCAGTCATCCTAACTATTTTTCACTATTTTTTTTAACTTCTGTTTTTTTGGTACTTTTCTGGCCGTTTTTATGAAATTTTTTAGCCCGACATAGTTTACCTTTTTTTGTTCTGGATTTTAGGAGTTTCTGCGACCTTACTCTCACTCATGTTCGTCCTCCAGCCCCGCCTAAGCCTATGCCTTAACTCAAGCCTAAGCCTAAGCCTAAGCCTAACCTAAATCGCGTCAGAGAGAGCGTAACGCTCGCCACTGACGCCAAGCCTCAACCTAAGCCTAAGACTAAGCCTAACTCTAAGGCTAAGTATAAGTAAATCTAGGCCTCGGCCTAATACTAAGCCTTAGCCTAAGCCTAAACCCAAGCTATCAGAAGACACTCAAAAAATGTTCAGATCATTAAAAAATAACTACATTCAACAGTTTTCTTCAAAATTTAGCTTTCGACTTTCCAAGTAATCAATAACATGATTCCAAAATCTTCATACATCCCTCCCCTCTTCACATCGTTCCCGACAGCTTGTACTATTTCTCCTCCACCCACTAGGCAAGGTCTGCGTCTCTCGGGTTTCATACGCTATCTCCCTTTTGTGGAATCAGTTCATCGTTTCGGATCGTGGCTTACTTCTCAATATCCGCGGGCGTCGCTTTACTTTGATATAAAGTTCAGTTTTTTGAGGCCAAAATTTAATTGGTGGAATCACAGCGTTTGGCGATGAATTAATTATCGTGTGTATTCAACTTTAATATACGTGTACATTTTACCGATGCATGTAAGTTTTGGTGTATCAAAAAATGCCCCTAATAAATTTCTTAAGGGTGGAGGAGCGCTAGTGGGGAAATTGCGAAGTTTTATAACATGCCTATAGTACCACAATGACCGAATATCATGATAAAAAAATTCAAAAAATTTTTAAAATTTTATATGATTTTTTTTAGAGGAAATTGGAAAAATCTCAGTTTTTACACTGCCTAATTCCAATTTGACTTACCGGTAATTTTGTTCGATGGAGCGCGCTTGCACGTTTTAAAATTTATTTTATTTTTTGTTATTTTCCTTTTTAATGTTTTCGGTGTATTTTTGCTCTAATTTTAGAGAGTCAAGATGAATGCAGATTTTACGATTAAAAAGCACGCTCACAGGCGTAAAAATGACAGAGCAACGATTTTAAACGGTATCGAACCTCATCTATATTAATTAATATCACAGATTTACGACTGGTGCTTTTTAATCGAAAATTTGCATTCATCTTGACTTTTTCTAAAATTCGAGCAAAAATACACCGAAAACATTAAAAATTGGTGGAAAATAACAAAAAATAAAATAAATAAATTTAAAAACGTACAAGCCCACTCCATCGAACAAATTCGATAATGTGATTCAAACTGAGAACTAGGCAAAAACTGAGATTTTTCCATATTTCGAAAAATCATATAAAATTTAGAATCTTTTAAAGAATTTTTTTATCATGATATTCAGTCATTGTAGTACTATAGGCATGTTTTAAGAGCCAGCAACCCACTGGCGCTACGCCTCCTAAAGTTTGGAGTTTTAGTAAAAAAAGATCGGTTTTTTAGTTAATAATATTAATATCCAGTCGCTCCTCCGGAACAGTTCGACCATTTTTCACCACTCTTCCAGAAGTACGTGGAAGAAATGTTCCTATTATGAGATTATTCGAGAACTATGCTGCATCGTGGCCGACCAAAAAGTCTCTTAAAAAGGACTTTTTGATCAGCTGGCAAATGTCGGTTCCCGCAAAAAGTCGTATTTCGTGCAAAACCGGCAAAAGCAAACATTTTGATTACCGGCAATTGTCGGAGTTGCCGATTGCCGGAAATTTGCGGAAAGAATGGTCGTTTGATACTCTTTTTTAGATTGCCTAAAAATGCATTTTAATGAACAATTTTTAATTTTCAAGCTCAAAATGATTTAATGCTTTAAGGATTGTCCGTTTTCTTTAAAAAAGACTAACCGAAAACTATAAAAAAAGGTGAAATTTTTTCAATTTCCAAAATATAATTAATTTTGGCAGCCGATTGCCGGAAATTGCCGATTACCTTACAATACGGGACGGCAATTGCCGAAATTGCCGATTGCCGGAAATTTCCAAAAGTAATTGCCGGATTTGACGATCGCCGGAAATTCCCTATTGCGCTCCCTTGTATTAAAGGATACGGCAAACGATGTTTTCCCGCAAGCGTATCGGCAATTGCCGAAATAAAATATTAATTCGGTGCTCAAACGGCAAACGGCAGTTATAACAGCAACAAGCCACTTCTCCAATTTATAATCGGCAATTTCGGCGATAAACGGTCAATTTGCAAGAAATCAAAATTGTGATCTTGCACATTTTTTCTGGAAATTTCAGAATTTCAATTTTAAACAACAACATGGTACCCTATGAACATATCTTAAAAAACCCGGAGTGAATTCTATAAAAACTACCTAGAGAAACTGACCAAATACTTAAAAAAGGGACGGATTCATGTGATTTTGATTAAGATAAGTCTTTGAAAACTTTCGGAAAATTGAAATCCGGCAAATCGGCAAATCGGCAACTTGCCGATTTCCCGAAATGGCCGCAGCAATGAACTACACTGTTCCAAATCGAATTCGTAACCGATATTATACTTAGGGATATTTGTAACTCGTATAAATATTAAATAATATATATATATTCCAGCTGCTCCAATCTCTCCAAATGGATGCAGTAGCCACAGGCTACAACTCCCTATTATTCTCAATGGCTGATATGCAAATCGAAAAGGTCATGGGTAAATGGATAGACATTTGTTTATTCGAAAGAATAAAGAGGATTGTTCAATCTTCTATTGTTAGTTTATTTTCATTCTGAAAATGAGATGCAATTTTCAGTCGATATGGTACTTCGAACTCTATACACCGCAACATTCACCTCAAAGCAGGTCGGAGTGATTAATAATGATGTCGTCACCAATGTGGAGTACGGTAGTATGGTTGGTCGAGAGCCCGCAGCCGTTCTCAACGTAGTGTAAGGGATCAGTCTCCATGTAAGTATTTTAAATATCTTTGGTCCGGTGATGATTAAGATACAAGTTTAAATAGTTCCCGTTTCAAAACTTCGGCTAATTTCCCGCCAAAACTTTTCTCTGAAAAATTTTAATTACTTTCCAAATTTTTTTCTTTGAAAATTTGGACTACCCGCCAAAATTTTGTAGTAAAAAAATTGAATTTCTTTCATGGCTCCAAGAATGTTTTCTCAGAAAATTTGAATTTCCCCGACCGCCAAATTGTTACTGTCAGAAATTTTGAATTCGATTTCTCGCCAAAATTTATTTTCTGGAAATTTGGATGTCCCAAAATTTTTTTCTCAATAAATTTAAATTTCCCGCCAAAATTTTCTGAAGATCTAATTTAGCGGATATTCTTTCCAAATTTTTTTCATTGAAAATTTATTGAATTTCCCGCTAAGACGAATTTTATTGTCAAAAAATTTGAATTTCTCACCAAGACTGTTATCTCAGAAAATTAGAATTTCCCGCCAAATTGATACAGAATATTCTAATTTCTCGCCTAAATTTATAAATTACTGAAAATTTGGATTTCCCGCCAAAATTTTGTTCTCAATAAATTTAAAATCTATCTCCCGCCAAAATTTTGTTCAAAAAATTTGGAATGCTCGCCAAAATTTTATTGTCAGAAGAAACTTAAATTTCTCGCCAAACGCAGGTCTTTTCCAAAATTTAATTCCTGTCAAAACTTTGTAATCAAAAAATTTGAATTTCCCGCCAATTTTTATTCTCCGAAAATTAAGAAGGATTTCCCGCCAAAACTTTGTTCTAAAAATTTGAATCTCCTTTGTCGCCGAAATTTTATTGTCAGAAAATTTGAATTTCGAAATCTCTATGAATAAAACATTGGCAGTGTTCCCTGTACGAATCGGTGGCTTGAGTGACGAAGGAGAATATCAATACATGATCTTAAGTACACCCACTGTAAGTATCCAACGATGCTCTTGACAGGCTAAGATTGCCTTAAAATTTGTTTTCTAATTATTCCAATCTAATCTTCATGTGATGTTGCGAAAAATGCAAACATGTATTTTAATACATTTTCCCCCTATTGATGGCGTCGAAAAATGTAGAAAAATGGAATCATTTTTGTGCATGTACATTTTCGACATTTTTGACATTTTCCGACATTTTTCGACGTTATTAGACATTTTCACGCATTTGACCGAACTAGGCAATTTTGGGTCCGTCTGGGGTAGATTTAAGGAGCGGCGCGTTGCGTGTCGCGTCGCGGCTTGATTTTAGTTGTATAACTAAATGTAATTGCTCCGTGTGGAGTACACGACTTTCCCAGGCAATTGTCAATGGAGCGCGAAAAATGCAATGAGGAAGGACAGAACCCCGTATCCACAGAAAGAATTTTCTCTGCGTCTCTTGTCTTTAGCATTTAAACTGGGGCGAGATGTAGAAAAATGCTGAAAAATTTCGAATTGAAAAATAAAATGATGGCAATGTTACATTTTTCTGCAGTAATTGCGGTACGCAAAAAGCATCACATGGATAACCCCATAAAAACTCCCATTTTTCCAGAGACCTAACACTATTCGAAAGGAAATGGAAGCGTGTATGATGATTTGTTGAGAAGAATGGTTTTATAAGCGCAAGTCCAATGGCAGCACTGAACACTCGTCTGCATTTTTGCACAGATGTCTATGTTTGCAGAAAAGTGAATAATTTATATGAGAATGGAAATGTTTGAGTTGAAGATTATCTCTTTTCTGAGGATACGGGAGAGTTCAAGTTTGACGGGTTGTGCAGTGTTTACATTTCTAACCTTCATGTGTTAAAAATAAAGATTAATGATTAATTGGATCTGTATTTAAAATGAACTTTTAAAACACAAAATTTCAGATCTTGGTTTAAAAACGTATACACTTGAAACTTTGTTGAGTGTAATGACGTAATTTGAATTTCGCGAAAAAATGACTGTGATATGATTTTGACCGTGTACACGGGCAATAATATTTTAATATTATGGATTATAAGCGTTTTTCAGTAGACTTTCCATATTTTCTCATGATTATTACTTTTATGACCCAAGAAAAGCATTGTTTGGAACTCAAAATTATCAACTTTAAATGTTTAAAAAAATTCAGGAAAACATAATATTTGCGTATTAAAAAATTTCCCAGTAATTTACCACAAAAAAGTTTCTTTTTCTTTTTTTAATTTTTTCTCAGAAAAATCAAATCTCCCTACAAAGTTTTTCTCAGAAATTTTGAATCCACCGCCAAAAATTTTTCTCAAAAAATATGATTTCCCACCAAAAAAATTTTTCTCGGCACAGAAAATTTAATAACAATTTCCCACCAAAAATATAGTCTCAAACTAGAAATACTAAGAGCATTTTCCCGCCAAACCACTACTTTTTTTAAAAGAAGATTTGAATATACCGCCGAAAATTACTTACCAGAAAATTTCAATTTCCCGCCAAAAATGTTTTCTCAGAGAAATTTTTAATTTTTGGTCAAAATTAAAATACTACTACGGTACCTTAATCTTACACCTCCACCGAAAAAATCATTTTTCAAAAACTACTACAGTACTAACAGTACTCCTACCGTACTGCTAAAGTACTCCTACCGTACTCCTACAGTACTCCGGCAACCGTACTCCTCTACAGTATCACTACAGTTTACTCAAACCATATCACTAACACCAATCCAATATCCCGTCACACGACGATAACTTTTTTATTCAAAAATACAGTAATCTTACTGTAGACAATCTTTTAAAGTCTGCATCCAAAACTATATCGGATCCCAAAAGTAAACGACAGTCAGAAAATTTGTATTGGATTTCGCGTAGTTTGCTCTTCCGTGAAGGCAACACACGTAGCTATATTGATGCGATGAAAAACGAGAGGAATCAGTCGAGGTGTCTGATCTACTTCCAGGAGACCGCTCTTCGACTCCTATTGGCTCTTGCAGCCACCTCATTGGCGGCTCTTCCAGATTTGGGATATCCCGGATGGCAGTGCGATGCATCGCTTTACCATCCGAAGTAGCTTACTTTAATTACTAAATTTTGAAAGATTTTTCCTCGCTTCCATGAGCAAAACTACCCCGACTTCTGCCCACTCCGTCCGACTCACCGACATAAAAGTTTTGGGAGGAGCTCTCGTTTGGAGACTCCTTGTCCGCCGCCAATGGAGCCGGAGCACCAAAGGGAGAACCCTCTGGCTGTGATCCTTCCGTCAGTACAGAGCACTAGCCTTCCAGTGTGGAGCGTGGTGACCAATCTCTCGACGAGCATGTCACTGTTGAAAGTAAGCCATTTTTCTGAAAGCGGGAATTGGGAAAAGTGAGTTGTTGCTAGATGTACTGAAAAAGTTCCTAACCTAATGGGATACTCCACTGGAACTAGTTCGGAAGCGCCAACGTTTGGGAGGTCTCAAACCGAACCAAGCAGTTCCAGGAACTGAAGCAATCGATACCATCACTTAGATGCTGCCAGAGCTCTGGTGCAGATTATCCAAAGCCACGAGGAGGTGATCTAGCAAAGTCCAAACTAAACATCAATTCCGATGCATTTCCAGATTAAAGATTACAAAACTGATTGGAAGTTTACGTATTCATTGGAGCAAACGACATGTGCGCCTATTGCAACGACCGAGAAAATGTAAGATAGTCAACGATCATTCCACACCCGGTTTTATTGCATTTCTATAGGGCCTCAAAAGCAATCTGCAAAATGTCACTGCCATTCAAATTTTAAAAGATAACTTACCAAGGTAGGTAAACTATAGGAACATAACATTATAACAAGTAAATAACTATAATATTATGAAATTGTCACATACCTATACCTACGTATAAATACCTAAGTAAGGGTCCAGAGCGGTGTGGCAAAAATTTTGAAACCAGCAATTCGGCAAATTTTCCGGGGTCGGCATACTTGGTAAAGGGATCGCAACATTTTTTGGAGCTCAAAAAGTGCCAAAATTAACAGAAAATCTAAGTTGTTAAACATTTGTGGCAAATTCCAAATTTGTCTAAATTTTTGAAATATGCCTTGCTCGGTCAAAGGTATTTCCGCAAATTTGCCGTGGTTGTCCTCGGTAAAGCGCATCATTTTTTGGTGCTCAAGAGTACTGAGTTGATGGAAAAGCACTTGTTTCAGGAAACATTTGTGCGAATTACAAATTAAGTCCAAATTATTGAAATTTCCTTGCTCGGAACCCGGAGACCAAATTCGGGAAATTTGGCACACCCTTGATCCCATAGCAGTGGCGCAAAAAAATCTTTAAAAATAGCTTGTGGCCGTTTCCGTGCCAATTATAAATTAAAGTTAAACATATTATCGAAAAAATACGATTGCAAATTTTTGGCACTCGTAACTTTGGACAATCTACCTTACCTGTTGACTAGGCTCCTCCCCTTCCTTCGACAAGACCCAAAATAACAACGGCAAAAAGATTATGGGCAACGTGGTGCCAGGCTGTCCCATTCCAATGTTTGATCTAAAATAAGGTGGGAATTTTTCGCCCAAAAAAAAAGTGACATCGGCACGTTCTTACCATATTGCCAGTAAAAGTACTCTGCGTCTCTTCTCCCGCATTTTTTGTAGACCAGCGTAATTGAAGCCAAAATGAGACACTCTGACACCACGTGGGCGGAGTCAACTTCCACAGGTAGAACAAAAATTAATGATGAAAAAAGATTTGCGATCGGATTTTTCGATAATAAGAGCCAACATTTTCGGCTTTTTATGGAAATTTTTTTTTCAAAAAGAGGTACTCAGTACTGATGGTCCATAACTATGCCATCAATACCAAGTCCTTCCAGAACCATCGTATCGATGCCCGAAATGATCGACATGGCCATGATTCGCGAAATCGACCACCACAAGTATTTCTGCGACGGATGTGTACGAGTGATGCGAGAAGAACAAGGACTTCCCGAATACCGACAACTCGGCTGGCTGCCATGTTTACATGGATGCTCAGCAGGAGATTCAAGCCTCGGGCGAGTAATCTTCGACTCAACAGTTGACTTTACATTTGTCGTCCGATTCAACCATTCTTCAATGGAATCACAGTTCCACGACCGCCTCAAGACCGTCGGAGAAGTCAATCTGGATTGGTTTGCAACGGATTGATTCCATTTCTCAAAACTAGGCCACGCCAATGTTGGCAAGCACGTTGTGGAACAATTCAACCAGTCGGATCCAAGAACCATCAAGTCATGTCAGATCCTACCATTCCACTAAACTGCCCAGACACCAAGTGCCCTCTGTACAACTAAGAGTTGACTGCTCGAAATATAGGACTGCCTAGACTGTAGGAAATTGAGTTTGTGTGTGTAATTTGACGTACTTATCGGGTCTGCAATAAAATGTTTTAGTAATCTTTAATTTTTAACGTGTGAGACATAAAAGAGTACCCTCAATAAAAATATCCTCGTGGACACAATATAGTTATCCCAATAGAGTCAATCTAATTTTTGCAATTATTATTTATTAAGAATGGATATCAAGGTAAAGGAAGGGATCTAGATTTTGTAAAAAAGATACTGGAAATACGAATTGTTACGGGATTTCATAGAAGGGGATATATCACGACTTTTTCTTTGAAAAAACAACATAAAATGATTGCGGCTTCACAATCTGATCATCCGGTATTTCTCCAGATCCCTTTTCCGATTCGATCTTACTTGATACGCCGGTTTTGGACCTACCAGATTTTCATCTGGAAGAAATTTCAGCTATGCGTTGAGTGCAGCGTTACGCGTTGCGTGCTGCGTTTACCGCGTTGCGTGCCGCGTTGCGTGCTGCGGCGGGCTTCGTTGTCTCGTGCCGCGTTGCGTGCTTGTCCGCGCTGCGTGCCTACCTTGCGTCTCCGTGACATCCAATCGTTTTGCAGCTCACTTGTCTCACTACTTGACAAATTTTCGCCTCAAACTGCTTCTCCAGTTCGAATACTTGTTTCCCGGAAAATGAGCATCGTCCGCGCTCTTTCTTCTTTCTCTTTGTTTTTTGACAGTTTTCTACAGGAGACTTTTTGGCTTGGTCGAGGCTGGATTCTGAAAAAATATTCTCCTAACGGCTGATTAGTTTTCTACGTGTAGCATTTTACTGTCGTCGAAATTCATTGAACAACCCTGTTAGTAAATTTCCAAAAAATTTTTTTCATAATTTCGAAAACTGCGTATTTTAAATTTTTTCACATTTTCTAATATTTTAAAACAAAATTGAGAGTAAAGGAAAATTGTGTCTTGTAATTTTTGTAATTTTTACTCAAAAAAAGGCCAGTGAAGTACTATTACAGAAAATACGAATCGATAGCGCAGTCAAAACTAGAGAACATCAGTATTTCACCTCAAATGCACCATGCCCAAAACTAGTCTATTTTTCAACTGCAACACTTCATACACCTAATCAAAAGAAATCAACTTACTGATCTTCCAAATTCATCAATTTCTCCATTAAAAGAGACATAGGTAAGTCAAGTATATCCTTTATCAGGTGACTAGTTATTCTCTGCGGCTTCACATCAGACGTCAACAGGGCTCCTTAAAATAGCAGGTTGAAGTAGTTAGAAGAGCAAGTCAGTTTCCATTTTGCACGACTGAAAAGAACTTCTGAGAGACTTCTCAGTACGTCTCGAGGTCCCCGCCTCCTCTTCAATCAAACAATTGTAAATTCTGGACTCACGGGGGACTTTTGAAGGTTGACGACGACGACAATTTGCCCAAGTGCGACAATCATTGCGCAATTGGTGTGCAAAGAAGAAGATGGGAGATATGAGTTCTGAGATGATGACAAAAGCATGAGAGCACAATGAATAAAATGAGACCGGATTTCGAGAAGGAGGAGGGGGAGAGGAGGATTGGTGGTAAGGGCTGATACTTGATGCAATTGAGGGAATGCGTTTCTCATACTTGACTATTTAATACTTTTCTTGAACCTTAATTATTTGGATTGTAATTTTGTAGCGGAGGCACATGTGATATTATTGTGCTAACTTGGGTAATCCTTAGACTTTCAAATATAACCTTCATTATTTGAAAAAAACTTTTTGAATAGACCTGCAAGGTTGATCTACAATTTTTCATGGAAATCGAATTAATTTTGTAAGGATGTCTACTGAGTATAAGCTTATCGTTAGGCTTAGGCTGAGGTCTAGACTTAAGGCTACACTTAAATTTACTCAGGATCGCCCTAGGCTTCGGCTTCGGCTTAGGCTTAGGCTGAGGCTTATGCTGAGGCTTAGGATTATTCTCAGACTTACGCTTAGGCTTACGCTTAGGCTTAGGCTTAGGCTAAGGTGTTGGCAGCTTAGAATAAGCTCAGGCGGGGGTGACCGCGGGTAGAAAAAAAAGGAGAAACTTCCAGAAATTCACAAAATTCAGAAACATACCTTTCATAAGTTTATTTTTTTACTAAAAAATTACTCTTAAAATGTATGCGAGAAACCCGCATGCAAAAACACCTTTTTTTTTTTGAGCAATTTCTACCTTTTTTTTATTTAATTTAAAAATACACTAAAAAAACCAAAAAAATTTTCCGAGCCCAAATTGCTCCCAAATGCTCTAAATTTCTTTTGAAGTCTGATATATTCCTATTAGAACTTGAGGAAAATGTAAACCTAGAGAAACAATACTACGCATGTTAAATGTAAATTATTAGTTTTAAAAAGTCGTACGTTATTTTGGAAAGTTTGAGGTTTTTGCATTTTTTCCGTATATCACTGAACACTTTTATTTAAATATCATCAATTATCGGAAGTAGGTTGCAGGAGAAAAAATATATTCTAGCGGGGTAAATTGAAATGAGACGGGGATCATTTAACTAAAATCGAAAGTTAATAGTTGGTGATCTACAAAAATTCTTAAGACAGTATAAATTCACGACTTCCATCTTGGGAACATTCTTAAAAAATGTCAACGAATAAAAATCTGACATTGTGGCAAACAAACTTCTAAATGTTTCAGACCTTATATAGCGGACATGACAGTGGCTTGCTTATTTGATATGACTTGAGTTTATTTTTTTTTTATTTCAAGCGTGGGGAGATTTATTTGCCTAGATATATATATAATTATTACTGGAACGAACTGGAAAATAACTTGGGATCAAAATCAAAAATTCAAACCTTCAATAGAGATTCAATCTTTTCGAAACTTTTTCTATAGCTTTGTCGAGAACCAACAGACCACGTAAATACTTATAGCTAAAATTTTATTAAGATTCTAAGTCATGGTGAATCGAGAGTTTGTCAAGTTCCATGTGGTTCCTAAAAATAAACCGATACACGTGGTGTCAGGCTGTCTCATTGCGGTTTGATCTACGAAAAATGCGGGAATATTTTTCCAGAAAAATTGTGACGTCAGCAAAAATAAATAAGGGTCTAACCACAAAACTGGTACTTGAATCTTGAATATTTTTAATTCACCCTAAATTACATTCCCCTGATTCCGAATATCTATGATGACTGAAAAAATTCAAATACAAAAATTTCCTGACAAAGATTTATATTTAAGCTAAATCTTTCATCAAATTTTTTTTTTAAAAATTTCATGTACTCGCATCACTTTTTTCAAACTGGCGCCCAAATAAATTAGCGCGCGCGTGCATCGTTTGACCTTTTTTTCGTTTTTTTTATTTCTAGCCGAATTCAATTTTTTTAAAACCAGTTTCAGTCATTTTTGTCGGTTTTTTTTTCTGAAAAAAATGTAAAAAAACGACAAAAAATCAAACAATGCATTAACAGCGCGCTCCAATGCTAATTTATTTGAGCGCGTATTTAACAAAGAAAGAGACCGGGATACAAATGAATAATCATTCGGCGATCTCAAGCTTAAATACATGGAAAACTTGTTTTGAATTTTTAATCTTTTCACATACATACTCGGAATCAGGGGAAAATTAGGATTCATTCAAAAATATTTCCCAGATTTCACTCGGTACCCCACCTTTAAAATTTTTACATGTTTTGGGAAAACAAGGGAAATTTCTAGAACCTATTTTATGCCAATACCTAAAATGCTGAACATAGATAAAACACACACACCCGTATGAGTATTATATACTTCCAATGAAACATTTGAAAAATAAAGAGTTCTCAGCTTTGATCATCCACTTGTGATATTCTCACGCGTAATAGCACATGGCACCAGCTCAAAGTGCTCATTTTGGCTATATATGAAGGTATATGAAAAAGTGGAAATTGGGAGGAAAAATGGCATGTTGACTTCTCTACGTGGCCTATGTGTGAAAAAACCCTTCTATGACAAATTCAGTTTAATTTTTTAATTTTTCTTTTTAAAATTCTAAAAATGGCTAAACGTTCAAAAATTTTTTAAAAGCCAAATACTATTAAATTTCTTTGTTGATTTCTTAACCCAAATTTACGATTTCAGTCAAATTTTTGAAAATTACAAAAAATTTAAAATACAGCTACTTGTAAGATGCGCAAAACAAGAATTACAGAGTTTTCAAACTATACAACAGACAACTCTAGTGGCTGAAAACTTCCAAAGTTAAATAAAAATTCCAAAAAATCGATAAAAAAATGTATCTCGAAAAATTACCGCTATAAGAAAATGGCCTTCTCTATCCCAATGAAATTATGGAAATAGATTTTTTCAAAAGCGATCTAGTTGGACGCTGTGCAGGGAAAAAAAGTTCAAGCGCGCAAAACTTTCGCTAGAAACTCAAATTTGCCTCATCAGACCTTGTTGGATTTTTTTCCCAAAGAATTTTCAAATGCCGAATACCGAAACTCCAGGGCTCACGTTTAGACCTTAACATGAAACTTTTGCCATTTGAACGAGGCTCTTTGAATCTCTGTAAAAGACTTAGCGGCAGACGAGCACTTTGAACTACAAAAATGTCGCTAAATTGCTATCATGGAAATTTTTCACTACTATAGGAGCCCGGTAAAATTGCTCCAAATCATAATTTAAAATATTTCTTCATGATTTTTTTTTGATTTTTTCATGATTTTCGAGGTAGGAGCAAATATTCAGTTTATAGGATATATTTTTTTTGGAAAAAAAAATCTGAAAAAACCCACATATCCAATAAAAAAATTACCAAAAAGCTTTCAGAATACTTGTCTACCTCGAAATATCGTAAAATTCATACAATCTCTGTTCAAATAAAAATATAATTTGGAGCAAATTAATGGGCAATTTCAAAGTCTAAAGTAGTGAGCTATAATGCATACATTCCAGAAAATGGAATAAAAAATAAACTGAAGTCAAGTTAATCTAATCTCAAGTTACCTCCTCCTCCTTCCCCCAACAAATACTGCTCAATAGCCCCCAACCAACTCGTTCCAATTTGAATAGTGTATTATTTAACAAGCTCTGTCATATCTCTCTCCTATTTTTTTTTTTAAGTCATTTTTATCGTCGCACCCCTCGACCGTTGTTGTATTAGCCTCTCTTCCTTCTTCTTCTTCTTCATGAAAACGAATTAAATTTCTTCATCCAATTCACTCAAATCACATCCTCCACCGACACATTCAATTAATCAACCGGTCCTTAATTGAACACAACAACAATCACTATTTCATAAAAATTAGTGTTTTTAAATGTACATTCAAAAATTGCGACGGCTGGAAGAATTATTATTTACACCAGAAGAGTAAAATTTGTAACCATAGTTATGGTAGCTACGGTAACTCAAAAAATTAGGGCATAATTATGCGACATGTTCTCATGAGTGCGCAATAAAAATAAAGCTGATCCAATACTCTTGAAATACTCCAATAATCGTTTCTGATTCCGGGATTCCTTCTCAGACAAATGGAGCTCGGAGTGCTCAATTGGTCAATGTCGCTGTCATGGCACCAGGGTTGTGCGGCATGGATTTTTTGGCAATCGGAAATTGCCATTTGCCGTTGGAAACTCTCGGATTATTTTTTTTCGGCGATCGGCATTTGACGGTTGCCGAACATAAACTCGTTTTTTCGTTTATTCGCTTCCGCATTGTTCGGCCGACAGTGCTTAATCTCCTTGAGGTAATTTTTTTTTATATTTTCTTGTATTTTATAAACAGTCTAAATAATTCAATTCCAATGATAAGGAGTGTCTTGGTTTAAATTTTCTAGCACAGATAATTTCATTTATTAACGATCAGACTGGTAGGATAGTCAACGATACCACCCCAGAGGCTAGTATGATTCAAAATAACACATGGACATACAGCAATAGACAAAAGATCTTTGAATGGAGTTTTATGGTGGGGTGGCGATGTGTCGACCTAAAGAGTATGTCCTAAATATACGGCTAATAATTCAAATATGTTGTATTTTGGAAAGTGTTAGAACACAAGTGACTGTTTTCGGATACAAGAAGACACAGAGATGTCCCTTGATTGTTCACAGAAAGCGTTTAAGGATCCCGTTTGACTACAATATTTGCGGATTTATGTTTCAACGAATAAATGTAAACTCGAAATTTACTATATATACAGCGCTTTCATATTCCGTTTTTCCATAGTTTGTTGGCTATGTAGTCTTTGTTTGAAAAGCGTCGTCGTTTCAAAATGGTTTCTGGGATAGTGAGTCGGGGTTAGGGATATAGTCGGCGTACTGTAGTGGTACGATGGTGGTACGGTAGGAGTACTGTATGATTACGGGTTAGTCTCAGAAAAATTGGATTTCAGCAGAAGTCGGCGGCCGCGCCAGAGGTGCAGTCCACGGCTGGTATATACATATGTATATGTATGTATATATGAATACATATATTCAACTATTTAATTTAAAAAATAAAAAAAACATTTCTCACAAATGCCGAAAACACCGAAAAATCGAACATATTTAGGCATTCGCCGATATTTTGACCAACTATTTTTTTTAGGCGAACGGCATTCGCCTTTGCCGCACAGTCCTGCATGGCACCCCGACCGGTTTCGTGACCACAATAGTTTTGATCTGAACGCAATAGGAGTCAGGAAGTTAGGGGTCATGGGTGCTGTAATCGGACCCCCAGTAAAAAGCACATATATTGACAACAAATTTTGATCGCTGTTTTTTGTCTTAATTTTTTGTCTCCCCTCGATGCGCATTACTAGTAATGATGCTTTATTTTTTTTCATGTATCTAACAAATATATCAAAAAACTGAAATTAAAGCGCTTTTGTTCAAGTTAGCAAGATAACCATTATAAAGCATTCCAAATAGATTTCAAATTAGCAAAATAAAGTGGAGAAGCTAGGATAAGATTGGGGAGTATAATTTTTCGGGCACACCTTCAGACTTTGTGGCCATAATAGCCCAAACCCACAGTTTAGTGAAAACTAGGGCTTCATTTGCTATATGGTACCCGGCACCTAACCTCTTTCAGCAATCGAATCCCAAGCAACCTTCACATCTGTAACCTTGACAAAAAACACGCAATATCAAATGGAATATAGAATTCTTTATTCAAGAATCATCATCATCATTTTTTTCAATTTTTACCGAAATGCCGAGCATATTTTTTGTCACAAGGGGAATGGCAACGGCGGGGAGCCAAGAAAATCAAAAAACAATATGGACAGAATAATGTGCCAGCGGAGCAACCATGCATAAATAATGAGGTTGGTGAGATGAAGAAAAAACAGATAAGTTACGACGCGAGGAACTACGATTTTGAAAAATAAACTGCTAAATATGTGCTTAATCCTCCCAGGTAAGCGATTATAGGACGGTTCTCGCATCTTAGCTGGCAGTTTCTCTTTCCGTATTGTTCCAGTTGACGTTGGCGAACCCGGCGTCTGAGACGATGGTGTTGAATATCAGCGTCCTCCGAACTCGGAGGCGTCTTCCTCGATCTTTCTGGCGGCCTCGAGGTTGGAAGGTATCAGTGATTGGATTTGATTTATAGTTCTTCTTGAGTTTTTTTCTTTATTTTCCTGCTTGTAATTCTAAAGCAACTAGAAAAAAAAGTTTCGGAAGGCATCTATCATGCCATGATTTGCATACCCGGTATGGGTTTGCGCGCGCGGGGGGCTTGCAACATTTTCGTAAATGACATTACGCTATGAGAGGGGGGGGGGGTGTGTAAAATAGGTATTTCTTGTCTGTCCCCGTTATCAAGTTTCTTGACGCAACGCGAGAGAAAACATACCTTCTCGTTCCTGCAACGCGGCCTCAACGATGGAGCTCTGGATGGTCGCAGTTTCCCTCGTCTCCTTCCTCATCCGTCGGCGTACTCGACAGCTTCGTTGGTCACCTGGAAATTAGAAATTAAATTTTTCTCGATTAGTTTGGCCGAATATAAAAAGTAATACTAAGAATTTCCCCATGAAAGGCTGAAAAGGGGATTGAGGTTTCCTGGGAAAAGTGAAATCCCGGTCTCAAAATTTCTTTTAATTTTTTTGAGCTCCGTTGAATACCGACAACAAAAATGGCTCTGGAATTTGAAAATTACGGGGCACCGAAACACAACTTCATCTACTGCTGCCAGTATGTCACTCCCGCATTTTTCGGAGGCTCAATCGTAGATCAAAGGTTTCCGAATAAGTTTAGATTTTTATCGAGATTGGTAACAACTAGGATTGACAAATACCAAATATCAAATATTTACCCAGATGCAAGTTTTCTGGGTGCTTTGAACTAGAATTCCTGGGAACTGATTGTAAGTGTCAAAACGCCCTCAGCCAACCGCCTAAGCCTAAGCCTAAAAAGGTGTCTCGAACTTAAATTTCGACTGGCATGGCATTCAAATGGGTATACCGATGATTTTGTTTCAGCTAAATTTTTAGGGTCGAATTTTCAAGAGCAAAATTGGGATATTTTTAAAGACTATTAATTGTCCAAAAATCCAACAATTCCAAGTTCAAATGAGCTTTAACTTGAGATCACCTTCCCAAAACCTCAACAGTATCAACTTGCGGTGGCGGTCTCGTGGCGGTTGATGGCTGCTCCTTAACAATATCCAATCAAAGGTGCCTCATTGGCGCTAGGGCAACTGGAGCCTGAGTCCTCGACAACTGGAGCTGGAGTCTCTTCAACAACTGGCGCCTCGGTTTCCTCGATCACAAATGGAACCTCAGTCTCAACGACGGCTGGGTTCGCTTCTGCAGCGGCGAGGTGCTTCAGTCTCAGCGTCGATTTCTGGAACGATTTCCTCTTGGACAGTCTCGGACTACGGTTGGCTCTGGTGCTTGCTGTCGTTCAGATGCCGTGCTTGTTCTGGTGTGCTTGCGCTGTGGCTCGACAGGCTGACGACCCGCTATGCTCGACGGGTTTTGGGACTGGCCCCTGGGTGTATGTGGTGGTCCGACTATGCTCGACAACTGAAGTGTGGGTGTGAATATGTGGGTGGGAGTGGTGCGAATCTGACTAAAAACTGTAAAAACTAACCATGAACAGCCTGGTGTGTCCTGTGGTGGAGCTTGGTAGTCGTCCTTGAGAGACTTGGGTCACCTGGATAGAGCTGACTGGTTCCGATTGGTACCCTCCTTGTTGAACTTGCTCGACTGAGAGGGTGCGGCGTTGTCTCCTCAGGTTGTGGGGCGACTGGGGTGGGAAGCTCCAGCGTATGAGGGTCCTCGAGTGGTTGGTAGCGTATGGATTCTCCGATGCCGCAGCTTGGGAAGCTCCAGCGTATGATGGTCCAGCTTGCGATCCAGCGTCGCGAAGATGCTCCTCCTCCGATTGGTCCTGAACCAGCGTAGGCAACCTCCACCGACTTGTCCTTCGAATCCTTGTCGACTGGTCCCGAGACGAGGCTCCTCAGACTGGTCCAGGTCCTCCGAAATGCATGGAGCGGCATATCCGGCTCCTCCACCGATTGGTGCCGGTGCTGGTTGTGGTGGGGGTGGAAGGCGCGGCGGGATAGCTTCCGCGTCAACGCCTCCGGTTGCGTAACAGTAAACACATGGGGTTAATAGTATGGAGGTGGCTAAAGGGAAGCAGGTTTTAGTTTTGGCGGCCAGCAGCAGGAAACAGGACAGTGATTTTGCATGAATGGTGGCAAGTAGAATGCTTTGTCCTAAGGAAGACATCAAAAGATCTTCAGAAAGAAAGAAATTATTTTTGGAATCAGGAAAAAGCATTTGAATAGCAGTAGAAAAAATATAACAATAATGTATAGTCACTAAAATACAAAAAATAATGCAAAATCATCGTTAGCTCGAGCTAGAGCATGGTGGAGCTCATCCTCCGCACGATGGCTGTGATGATGGGCAACATCCACGGGAGCTGCCGGCACCTGTCTCCGATACACGCTAACGCAGCGCGACACGGCAAATAAGACGGCTACGACATGACTCTCATCGTATTTGAGAAGGCAGAAATCGCAATGGAATGCTGAGTAACTGTCGTCGAAAGGCAACGTAGGACGTGCGTTTTCTAACAGCCACCCCAACTATTAAGTCCGCCCATGGCCGTCTGGAGGGGGCACGCGGCACGAAGCTTTCCGAAAGACGCCCGATCGCGTTTGATCGATGATGATGATGATGAAGAAGTGATGAAGCCCTCTCTCTCCGACGGAGGACACCTTATTCACCTTGGGTGCGTGTGTGTGTTGCAGTATAGGTGCAAGAAGAAGCGATCTACAAATGGGGTTCGTGGTCATTTCCGAATGATCCAATGCTGGAATATTCCTATTAATGTGACTCGTGCCACCTCATTGTTACTACTTGCGTGATTGGATATGTACCGTTGTTTCCTTTTCTAGTTAGATTCCTGAACAGTTCACCTTTACCTAATCCGGTGATCGATGTTCCAATGCTCTTCCTTTCACTTCCATTGCAGCACCTAATCAGGCGGAATATCATGCTTTCACTACTCTGCAGGTAAAGTGTGAAAATCCTAAGTTTTAGATTTCAAAGATGTCAAAAACGATCGTTGATCCTACCGCGCTTCCGCATCAACTGATATCAGGTTTTTATTAATGACAAGATTGTGGCAGAGGAATGAACTGGTTAACTTTTAGGCTGATTTAGTCTAACCCCGTGGAAAAACTTCCAGCTTTTACCTAGCGGTAACTGCAAACTACGGAGGATTAAAATACATACATTTTGTAAAAACATACATCACTTTCATAAAAATTTCGGTTTAGTTCAAAAAAGAAAAACACATTTCTGTTTTGAGATTTTTTTTTTATACACCCAAAAATGTCGATGCAATTTTGATGTTGATGCACCTAAGGGCGATTTAAAGGAAATTATGACTTTGCTGAATATTTTTGTTGTATGTCTTGATTATGGGTTTGTAGGCTTCGATGGCAGGCGCAGGGGCCGACGGGTCCTGGCGCCCGTCTGAAACTTACGCCCGCTTCACGCCGGCCTTTTGCCTCTTTTTTGCATCCCTTTTACGTGGTGCCAGGCTGTCCCATCGCAGTTTGATCCACAAAAAATACGGGAATTTTTCGCCCAAAAAAATGTGATCGTCAGCACGTCTTTAACCATACGAAATCAGTTGAGTCTCTTCGTCTCCGCATTAGTAGATCTGTGTAGATCAAGCCGTGTAGCGCGCTGACAGCACGTGTGTTTCTCATTGGAAATTGGAGGCGAAAATAAAAAGTTAGGCCATCAAAGTTTCAGCAAAAGGCGCGGATTGAGGCGAGCTCGCTTTGCTAAAGTCAGGCAGGCAGGCGGTGAACGCCTACAGGAAAAAGATTTTAGGTTATATCTGTAGGTTTCCCTTTTGTGTGTTTTTTAGACCGTCCAAAGAATCGTATCAAAATGAATAGGTATTTTCTCGTTTTAGGCAGATAGGTAAAGGTCTGTAACCTGAAAATCCAGAGCCTGATAATCCACACCTACATAATCATCAATTAAAATATTCAGATAACTGATAATTTCCTGAAAATAAGATATCTGTAAATTGAATCAACACCAATTTTAGTGGTCCATCAAATGCAACATTGTATTGATATATAAACTTTGGTAGTCAATATATGTTTTCTTATGCATTCTTCTCACTACAGTGCACCTTGATCATTGAGTACTTCATCTATTCTTGACCACTTCCTAAAAAACAAGAAATCAATCACGGCGAATATCCAAAAAGCATTAAAAAAGTACATTTAAACGAATACATTATTATTGCCCGTTCAATCCTCGTAATGTATCTTTTGCAAGTTCCTTCTTCCTCTGTCCCGTTTTGCTCCAATTCTCCGCCATACCTGATATGCTCGACTTTTTCGATCATAGACGCGAGTTGCGCAACGCGCGAAAATATCTTGCGCAATGAACAAGGAGAAGAAGAAGAAGAAGGAGTAGGAGGAGCCAAATAAAAAATAGGTGATAACCCGGGAGATGTTAAGCCAAGGAGTAAAGTGTTATAGCTTGAAGAAGGCATATTTTTGTTTCACTCCCCCCTCTGACAGCTTCTTCACTTTCACTCCAACCGTTTTTACTCTGAATGGTAATAGTTGACGGATCGCAAAGGCAAAGCCCTAATGGTCATGATTTAGAAGCAGCGGGGGTCTTGAAGGACGATCGGACAACTGAGATATGAAGCGTGAAAAACGGAACGCATGCTTATAAGAGGGGGAGATATATGGAGATTTGTTGGGAAAGAGCTATGGTACCGATTTTAATCCGGTATTGTGCTGGATTATAGTGTTTTGAAGTAGTAGCTAGGCACTGAAATTCACCCTCTAAGCCGTTAGAATTGCACATATTTTAAAACTATGCACCAGTTTTCTTAAGAACTGCTTGAAAGTTGAATTTGAACTGGTAGTTCTTGCAAAGAGGTTGAACTATCTGGTTTAGTTGCGTCCATAGTGCTTTGATAGCCCTTTTTAATTCCGCCAAGAGGAACGCCGGATTACCCATTTGCCGGGGATTTTCTTTGGCAAAGGAAATCGCCGATTTGCCGTTTGCCTAAGAAAAAATTTTTAACAGACGGAAAAACTTAACTGTGTCATTTTGAACTTATTACCGTTTTCTTGAAATATTTTCATAGAATCTAACTTTTGTAAATTGGAGATGAAGGAACATTTATATTATTTGAAATTGAAATTGTGGACCTTAAAAAAATAATTTGCAAAACCACAATTTCCCGAACTGCCGTTTTCCGCAAATTCGGCAAGTCGGCAATTCGCCGATTTGCGTAGCGAAAATTACAAGCAATTTGCATCGGAATGACAAAGCAATGTTTCCTAACATAAAATTCTAATTTTCAAGAATGATTTTTTTACTCAAAGTATTTTTATAAAAGAGCCGAATTATTTTAAATGCCCGCGCAAATAAGTGACCCCACATTTTTTACATTATTTGTATTTTCTGGCTAAATTAATTGCGGTTTTTGAATGTTTTTTATCTTTAGTATATAACTTGAGTAAAATTCACAGTAAAAATTAGTTTTGACAAGTCGATTTTTAGTTTAATTTCAGTTTCGGAGTTTCGGCAAATGTATTCTCAATTAACAAGTTTTCCAAAAAAAATCTGACAGAAAATTGACAAACCACGGTGTATCAAGCCGAGAAACCCTGACACCACTTGTGATTCCCCTTGGAGGCCCGCCTAGATCAAAAGTTGGGCCACCATCATTTTTGTTCGAACTCAATTGGTAAACTTTGCAGACTAGGCTGACACGTGGTATTTAAATACAATTTTCCACATTTATTTTCCACAAACCGAATAAAATCCTTATCTGAACAGTGTTATATAATTTTTTTCTTCAGATCACTCGACAATTTAAAATATATTACAGCATTCTTCTTTAGATGTTGAACGTTGATGCTTAGGATAAACATGAAAACCAGATCAGCTTTTCCGTGACCTCAAATACTCATTTTCTCAAATTCTCAAAAATGTTCTGCCTTCTCCAACGGTCTCTAAAAAAGCTTGGAAAACCCACAAAAGGTGTCTTGGGAGGGACACTCTCTTTTATCGATGACCGGAACGCCGGTATAAATGGGTTTTGCGGACTGACACCAGCAGGTGGAAATGGGCGACACTAGTAAAATAAAGAAAAATAATAATACTGAAAAAACAACACGGTATGCGAACAGAGAGTAGTGGCAAGATCGGAAGAATGGTCGGGGGGGGAGGGGGGGGGGATTACATAAAGATGTCGGCATAAAGTGCGTTTCATTAGGGTTGGGATTTTTATAGGGGGAAACTTTGATTTTTTTGAAAAATAAATTAAATAAGAAAGAAGCGACAACAACCAACAACAAGGTCATTTTTAAAAGGAAAATTTGGCTTGAAACTTAAACATTTTGGGATGAATTATGAGGATATACTCATAGATTAACCTAATTTAACAAAAAACACGTCGTCGAAATTTTTAAAAATGAAGCTACTGCAATTTTGAAATTTGGTGGTCCTAAGAAATCTATGGTTTTGTGGTATTTTGACGATAAACTGATTTTTTGTGTTTTTTTTCTGGTATTTTGAAGCCGCTGTACTTCAAACCCTTTTCATATTCTCAAAAATATCTTTGCAAAATTCGGTTTTCTCTAAAGAAAATTTCAAACTAAACCACTATTTTCAATTTTTAAAAATCTGCAGATAAGATATCGGAAAATTCCGGCAATTTGCCGATTTGCCATAAAAGTTCCGGCAACTTGCAGATTTTCCTATTTGCCGTAAATTTCAAATTCCGGCAAATTGGCGAATTCACGCCGGTCCTACCAGTGATGAATAAATCTTGTTTTTTTCTGGTATTTTGAGACCGCCGTACTTCAAACAATTTTCATAGTTTTACATATCTTTCAGCGAGCGGTTTTTTTTGAATATCAAAATAAACCAAAAGTCTACTTTTTGTGGTTTGTTTTTGTAATTTTTTTTTTAGAAATTTCAATTTTAAGATATCGGCAAATTGGCAATTTGCCGGTTTGCCGGAAAATTTTAATGTAGATCTGGCGATTTGCTGCTTTGCCGATTTGCAGGAAATACTCTATCCCTGATGTAAATTACCAGAATTAGAAATGTGGTATAGCACGATTGGCACACAATTTTTTAGTACTAAGGATAACACGCTGAAAATTAAATTTTTGAAAAAAAAAATTCTTGAAATTGTTTTAGTAATTTCGTAATCAATTTATATCATTTTTAGCCTTTTGCTCCAAACTAGGTTTTCTCCCACGTGGCATCTCTCATTACACATAAAAATCCCTGCTAACTCAAAACATTAAGTTGTCAGAGATTCATATCCATGTCCGCTTCACTTTCCAACTTTTTCCCTCTTAGCTTATCTAGATATACGTATATCTATCTACAAGTGCAACAACGTTCTCTTTTCAAACATCCAGTTTATCTTCTGACCTTTGCAACATTTTTCCTTCCAAACTTCCAGATTGCATATTATTCTTACATTCAAAGAGTGTCTCAAGTTTTGCTTAGAAGAAACATAAGGTAAAATGTCAGAATATCTGTTTACAGCATTGTAATGGCAATTTATTGTAAATATTCGCAATTTTGAATCTCCCTTAAAATGGTTAATTTTGTAGTTAGAGGACTAAATTAATGCCCAAGAAAAAGTTGTCATTTTTCATTTATCAATGATTGTACATAATTTCATGCCAAAGAAAAAATTTTGCCAAAAAAAGGACAGTCATTAGAAAAAAAAACGGAAAAATGATCTGGATCAGTGATTCTTTTTTATTATCTAAAAATAATCAGCATAGTCAAATGTACCAGAAAAAAGCAAATAAAATGTACTAGATTGACCGGAAGATTATTTGAAAAATTGCAGAAAATGCACCAAAAGCTGCTTTTTTCAAAAATTCACAAGTAGGATACAATTACGGAGCTATTCTTTTTATTTCGTAAAACTCTTCGCATAGTCAATAATACCATAATATGTCGATGAAAGTATAATATCTTGTAGTAAGTATCTTTTTAAAAATTGATAAAAATATATAAAAGCTGTTTTTTTCAGGGAAACTGAAAATCCAAATGGAGGGAAAAACATAAGGCATTCTTTTTTATTGCAGCTCATAAAACTCTTCAGCATAGTCAAAAATACCAAAATATGTCAATTAAAGTATAATAGCTTGTACGGAAGTATTTTTTTAAAAATTGATAAAAATATATAAAAGCTGTTTTTTTCACTTGCAAAACAAAAGTATGGGAAAATCATATGGAGTCATTCTTTTGTATTTCATAAAACTCTTCAGCATAGTCTCCCAAAAATACCAGATTATATCAATCAAAGTATAATAGCTTGTACGGACGTATTTTTTTAAAAATTGATAAAAATATATAAAAGCTGATTTTGTCAAAGACCAAAGTCAAAAGTACGGGAAAATCATAAGGAGTCATTCTTTTTTATTCATACTCTTCCCAGAGGTCCATAGCCAAAAATACCAGAATATGCCAATCAAAGTATTGTAGCTTGTACGGAAGAATTTTTTTAAAAATTGATAAAAACAAATAAAAGCTGCAATTTTTTGAAAAATTCAAAAATTCAAAAGTATAGGAAAATCATATGGAGTCATTCTTTTTTTATAAAATTCTTTACGGAAGCATAGTCACAAATACGAGAATATTCAAAAGATAATAGTACGGAATTTTTTTTTTTTGATAAAATATATAAAACTGAATTTTTCAAAAACCCTTCAAAAGTAGGGAAAACTATATGGAGCGCTTCTTTTTTCTGTAAACTGTTCATCATTACGGGTAATACCTGAAACTACCAAAAAAAGTAAGCTAGCATGTACGGAAGATTATTTGAAAAATTGCAGAAAATGCACCAAAAGCTACTTTTTTCAAAAATTCAAAAGTATGGAAAAATCATATGGAGCGATTCTTTTTTCTTTTATAAAACTGTCAGCATAGTAAAATGTACCAGAGAATACCAAAAAAAAGTTGGTATGCTAGATGTTCGAAAAATTGTTTTTATGGCGTAATTTCTGAAGAGGAGTTTCGAAAATGTGAATATTTCCCAAAAATGGACATTCTTGCCACTTTTTACTAATTTTTGATGGGCTAAACCTAGATTTTTAACGCTAAATTTTACATTTATGAGTTACCCGTTTTATCGACAAATTCAGGCAGATTTTTATTTTTTCCTATTTTTTTAAGCCATTTAATCAGCCATAATAGTGAATGTCTTTTTGGGCAAAAAAAAATTTTTTAAGGCTGACCAATTTTAAGCTCTCCAGCTATAAAATGAACCATTTTAGAGGAGTTTCAAAATTGTGAATTTTTACAAATATTGCCCCAATTTTCCACTTTGTAATGGTTTTTGGTGGGTTAAACCAAGATTGTATTCTGCATACATGAATTACGCGTTTTCAACAAATCTTAACAAATTTGTTTCTATTTTTTCCAAAATTTTTTTCCCTCAGCCATCTATTCCTTTTTTTTGTCTGTTTTTTTAGGGCAAAAAAACCTTTCCCACGTACCACCTTTAATAACACGGTAAACTGGTCTAAAAATCGGCAAGCGGAATGAAACTTCAAGTAATATAATGCGATGAATTGAGTTTTTTTTTCTATTTTCTTTGTTGAAAATATCAATATGAAAAAAAATGAGTAAAATTATATTGACATAGTTAATCGGATATAAATAATAAAACATCACAAGCACATTTAATTTTTCAAACCCACTCAGGAGTCATGAAGAAATCCTTCTCTGCACATCTAGCTTTCTCCACATCCAACTACTTTTATTATCTCCAGCAAACTCCGTGTAACTTTTATTGCATACACATTCAAAAGTTTTGTATGATGCTTCAAGTCCCAAGTCGATTACACAATCCCCGAAAAGAGCATCGCTGCGAATTATGTCAATTCCCTCTTCTAAATGCACTTGTTCTACAAACTTCACTGATTTCCTTAGGATGCCACAGTCCCCAGGCAACAGTTTGTGCAAATTCTCAAGGTTTGATTTCAGTGGGCAAGCGGCAGGTAGCGCTCATTTTAAATTATTGATTTTTTTAAAACATTATTAACTCACTTCGTCGCTTTCATGTGCTCTTCTTGGATTATGGTCATATGGTAACTAAGAATCTCGAAAGTTGTTTAAATCCCAAAAAGATCACATTTTTCCTTTCAAACGCATTTTCTCGTTTACAATGTGACATCTCTTGTTCAGTAGTTGGAGTCGGCCTCTGTCGCAGATAGTGTGACCAGAGCAAGTGCCTATTCAAGGGATTTGGGTATATCATGATCTGGAAAATTTGGTATGTAGGGCTTCCATGGTAGGCAGGCGCGGGGCCTGGATGACCCGCTCCCACCGGTGAATTTACAATGATTTTCTCGTATAAATTTTGTCATTTTGATGAAACAAAATTGAGGGTACAGGCAGGCGGAGGTCGCCTCAACTCGGCGTTTGCCGCCACCAAGATTCAATCTACCTGTCCAAAGCATAGCAACTTCTAACCCAACCGCCTTGCCTCAAAAAAAATAAAAAGCTTAAATATCAAAATTACTCAATTTTGTGTCAACCTATTCTACTTTTCTGAGACAATTTGAATTCCCTCCAAAAATTTTATTGGAAAACAAGTTTGAACTTTCACTGGCCAAAATTTTTTTTGGCTGCGCCAAAGATGATCAAATATTCTCGGCAAGATTTTTCCCAGACCCCAATTGAACTTCTTGCCAAAAATTTTGATAATTTGAATGGCAAAAATTATCTTGCCTTATGGTGAGGACACAATCAATAGTTGTCAAAATTGTATATGTCTGTCAAATTTTTGATGTGTGTTGGCAATTTTGGCAAAGCATTTGCCGAGCTGTCTCGGCAAATTCGGCAAATTTGCCGAGCTCGGCAAATTCGGCAAATCTACTTTTCGAAATTCGCCAAATTTGGCAAACGGCAGAAAAAAGTACAGAGATTTGAGGTACACAAGGCTTACATCGAAATTAATCTAATTAAAAGAATGATCACTTACCATATATAGCATATACTGCATATTTCAGTGACCTTCTTCGCAACAATAGTCTAGACACTGCCCAAACACTACACACTTGATGCTATTTATGTACTTTCTATGCTGAGCAAACAGAACATGCGATTTGAGGAATCTTAGGTAGCAGCAAAAAGATTGACATATGATTAAATTCCTAATTTGTTCCTTAGCTTCCCGTATGTCAATTAATTCGTAGATAGTTGCTATTGAGAAAAGTTTTTCGAAAATTTGTAAGATATCAAAATAATAGTCCTCATTTTTAATTTAATGATAGAGTACTTTGAAAATTTCAACAATTTCAACACTTTTGTAACACCTATGTTATCAATCAAATACAACAGTTTAGTACAGTAATCCTACATTTCCAGCCCACGTGGTATTAAGACAGTGTTAACCTTGTTATTTTTTAAGGACTAAAAAAATTTAGAAAATTTTTCTTCCCATTTTGCTTACTTATCAAAAAAGCATCGTGCCCTCATTTAAAAAAGAAGGGTCGTCGCTGGAAAATGTTAAAAATTTCTCTCATGATGCGCTAAAATTACTTAACTGTTTAAAAACATTATAAGTATCGTAGCGAATTTCAAAAATCTTCAAAATTTAGATTTATTTATAGTCAACAGTTTTGGAAGTCAATTAAAAACATTTTTTACTATTTTTAATATTTACAAACGTTATAGTCAGTTGCTTGTAACTTTATAACTCCGTTGCCTACCGTACATTTAAAACAACCGTAAAAATCTAAGCTTTTCTCCCGATAAAAATCTTTACTCAGGCGCGCGACTCTTTTCTTACATATCTTTCTGAATCTAATCAATATTGAGCTCATACTAGCTGTAAAATTGAACATACATATAACTTTGAGTGCAATTTCGACCCATAATTTCAGAAAATTTTCACACACAGAAATCTTTATTGAGAATGATCAGGACAGTTTGACCTTTCATGAGAATTGCTTGGAGAAAATTCCAATCGCACAAAATTCCTCATTGCCAAGTATTTCCTTTAGTTTGTGGCCAACGCCTTAAAAAATAGAAGACATATTAAAAAAAAAACTCTGACACCACGTGATTATGCAATCCGACTCATCGTCAACACACGGGGTTCTGCCCTTCCTTATTGAATTTTTCGCGCTCCATTGACAATCACCCCACGCCGTCCGACACGTGTGAAAGTCGTCACTCCACAAGGAAAAATACATTTAGTTTTACGTTCGAACTAAAATCGAGCCGCGACGCAACACGCGACGCGCCGTAAATCTACACCAGCTACTCTATGGCCAACCGAAATGGCCTAGCTCACAAACTCTTCCATTTCAATTTATAAGCCAGAAACCCGTGCGAACTGCGAGCCTAACGCTCTTTTTCAAAATATCGTATAACTCGGATAACAAGCCATATTACCAATTCCTGTTTTATTTCGAAAAACAGATAATACAAAAGAAACATATCTGAAAATTAAGAATAGATTACATGTTTTTATCAAATACTTCTTTGTCTATATTCCATAAATGACCCCCATGCGAATGAAACACTCACTATACATTCAAAATGAATTTCGCACTTGTCGCTTTCCTCGCTCTCGCTAACATTTGAGGACTTGCACAGGGTGATCCAGGACTCTCATTTGAGAGAAGATTCAGTAAATATTGTAAGCTTTCGGATTAATGGTTACAACATCTATTAGATTGAATGGCAAAGTGCCAGTGGGAGCAGTGAAGACGTTGGTTAATGATCTTGTGAGCCCTACTACTATTTAGGGGGTGGAGAAAAACAACATTATCCTCATTGTCAGTTTAAGGAGCTACGGGAGGGCTCCATCTCAAATGTTTCAAATAACTCATATTGTACCTTTCTCTGGTGAGTAAAATAAATTACATATTCGGAATCCTTTTCTTTTTGATGTTAACCAAGTTGCCGGTTGCCAAATTTTGTTGGGTTCGGCAACTTGGGCAACTGGGTATCAATGTCAAACATTTTGAAGCTTAGAAAAAAGCATTCAGAGAGCCTGAAAAATTCTATAATTTCATTCTAAACGAAAACTACTTTTTTACCAAAACGCTGAAAAATATAATTTCAACAAAACATTGAAACGTGGTTGCCCGACTGAATATTTTGGGGTTCGGCAATTGCCGGTTGCCCGTTAACCTCGGTTGCCGCACGGCCCTGATGTGGAACTCGCCTAGTGTGTCGCATACTTCAATGTGAAGGCGTATTGTATTTTTTTAAACATAAATTAAAAATTCGCTAAAACCGTCATAGCATATATAAATTGTTTAGACCGGTGAATAAAAGGATAGGATGCCACGCGAGTGCGAACGCTTTTCTCCGAAGATCCAAGTCAGGACGTCGATGGGCGGGACCCGGTGGGCGGAGGTTAGTCGGATAGAGCAGCAGACAAAACATCCGGGCGGCGAGATCAAGTGCGTACTCCTCGACGGAAAGGGAACTTGAGGCGCGTGGATTGGTTCTCGTCAGATGAGGAAAGATTCTAAAGGGAGGCGACCGGAGCCAGTTGTGGGAGCTCCTGTCAAAGTCGTTCTCTTAAGGGAAACAAATAGTGGTGTTAAGGGGAAATGCGATGGGAAATCCGAGTAGTTGATGGCGGAATTTTCTCGCGGGTTTCATCCTGGAAATTTAATTAGGGCCGCGGATTTCAACTTGCCGAGTTTTTATTCGCTTTTATGAAAAAAATTACTCGACAAATGGTTTTTTTTAATTAAAGTATCCGAAATCCCCGAAAACAGGCCATTTTAGAGAGAGGTCACTAGAGGTTTCGCGACATGGAAATATGTATTCAAGGATTCTTAGGTAACTACCCAATTTTTTTACCTCGAGTTTAATAAATTTCAGGTAAATCCTCTTGAATAATTCTAGTTTTGTTGTTTTACACAAAAATTCGGTTCCTCTTTATTCCGCGGAGTAGCTTTCCAGAGGTTGAAATATTTTTCCGGAGTCAACTCCTACCCGAGTTTTTTATCTCGATTTGAAACATAATCGGCATAAGAAACTACAATTATTTGTTTTCGGGGTTAGAAACTTTAAAAAATGGCCCCAGAAAGTTGCTGGAAATTAGCTTTCCCGAGGTTTCATGGAAATTTGTTTTTGCGGATTTCGACTACCCGAGTGTTTTACATCAATTCATTTCTAATCGACATAAGAGACTACACTTATTTGTTTGGGGCGAAAGCTAAAAAATCCCCGGAAATCTGGATTTCTAGAAACTAGATTTCCCAGTTTGGTTCATGGAAATTTGATTCCGCGTATTTCAACTACCCGAAATTTCAATCTTTAAAAAACATCCAGTTTTTGTGAGATGTTCTTAAAAATAGCTATCAGACGTGATGGAATCCTAAATTTCTAACTATAGTTTCCGCGGGTCGAATTTCTAGAAATGACCTTTCCAGGTTTCATGGAAATTAGTTTCCGCGGATTTCAACTTCCTCGAAGCATTGGATTGCAATATAATTCGCACAATAAAAAAAGCCAAAAGGCGAGGATCCCTGGTAGTTTAAATCCGCAAGAATAGTTTTCTCTAGTTTGAAAAGTTAATACTGAAACCCTTACTTATGCTTTCATTAACCAAGAATTCGATCCGTCGAACAATTGCTTTGCAGTCCCAATATTCGGCGAAAATTTCGATGGTTATTCCGACGGTGCTCTTCGATTTTTCGCAGGGTTTGCTGATACCTGAAAAATCGATATTTCAGACTATCTATGCCAAAAACTAATTAATTAGTTTACCTTCTGACTAGCATCCTCCAGCTCTACAATGTAATGAATGGCGGCTTTATACTGTTTCAGCTTCTTCTCAAGTAAAATCTGAACACAACCCGTTTGCCGTGCCATTACTCAACCTGAGCATGAGCACTATCTTGTCGGCGCACACATGGCCCGAAGTTGAGAGCCAAGTTGAGCCCATTTTATGTTGACGGCGTCCTGTCGGCGCCACGTGCCAAATGATACATTAGGTGATCAGAGCACGGCGCGGTTCGGTTGTGGGAGAAGCTCGTTCATTACGGAAAGACAACCGGACACGTTCACCCATATCCCACTTCTGTAATTTTGTTTTTTTGGACGAAAAAAAACAACAAAAAATATCATTTTGACAAAATGTTAACTGTCAGAAAATTTGAAAATTGATTTATTATTTTTGTTTCAATTTTTAGTTTTAAATGAATGAATGGATTCCGATTTTTGTAGGAATTGTCGAAATTTTTAATAAGAGCCCTAGTAGGCATGTGTGTGTGTCTCATCGGCTTGACCTACGTAGATCTACAAAAAAATGCGGGAGAATCAGAGGTCTTAATGGATTTCTCATGGTTAACAATATGCTGACGTAACTTCTGGGTAAACACATATTTCCGCAATTTATTGTAGATCAAACCGTATTGAGACAGCATCTCTGCCTGGCTGGGGACGCCTCTTTTTTCCCTTGGAATTTTTTTGGCGCGAAATTCAACTTTTTGCAAGTAAGTGCGAATATTTTCAAGCAAAGTGAGACTACGTACAAAATTATTTTGCTGCCAAAGTTTTTGAGTTTGCAAATAAATTATTGAGCAAAATTCAAATGATATTTTTCTTTCGAAACGTAATGAAAAAACTCAAAGTTACAAATAATTTGGCGCGAAATTTGATTTTTCAAAGATTTCTAGCGTGGCAAAATTTGAATTGGAATAATTCTGGTCCAGAATTCAAAAATTAAAAAGAAATTAGTTTGAACGATGCGATGCCCTGGTTTTCATAGAGCTTCCATGTAGGCGTTAGAAAACGCCTGCCTGCCTTATGCCGCGCCTATGCTTGCATATACGTAAACTTTTTTTCATTTCGTATCCTAATTTGATTCAGTTGACAAGTTGATAGAATTGAGAAAATTATAATTTAACGCATTTATCCTCTTAAAAATGCAACAAAAAGGGTTCAGGGCAGGTGCCAGGCCCTGAAGCGCCTGCCTACCATGAAAGCCTATCGTAAATAATCCAAATTTAATTTTTAATTTTACTAAAATTTCGATGGCTCGTTTTTTTTCAAACATCACAAACCTGAACAGTCAAAAAATTTTCGAGACTCAAAAATGATAATTGGTTCGGCGAGTTCTCGGAAGTCTAACGCCCATTATTGACAAGTGTAGCACATGAACTCCAATATCCTCAAGATTCATCATATCCGCCTGAATCTCCGAATCACGCTTGATTTTTTTTTGTTCAATTTTTCTGCAGTTCAACTCCAATTACCTGCAGTCGATTCAATCACTTGTCTGATACTGCGGATGAACTTGGGGTAGAGATCAACTGTTTCTGAAATTACTGGCGCAAAAAATTCATTAGATTTCAAAGACCAAGTATTTCGGTACCTATAAACTCCTTCCATTCTCAGAACCCCCAGGGACGCCACGTGTCTCAATTGCAAAAAAGAGTCGGTCCCAGAAGTGTTGGCACAGTATGCTCATCATCGACGATTGATACTAAATAGGCACCAAAGCTTCCACCAAGTTTGTCTGAAATTCAATCTTTATAATAGCATTATAAAAGCATATTTGTTGCAGTAGTTTGTAACAGGGGTCAGACAAATTGCCAAGCAAATTTCCGCTGGCAAATCGGTAAACCGGCCTCCCGGTCTGGATTTGCTAAAAATTTTTGGCAACCTTCTTTTGGAATTTTCAGAAAATTTACATTTTTATCGGCAACCCAATTTTACGCATCGTATGAATTTTCTTACATTTATTTTGAGAAGTAAGCAAATTCTATGAAAACATCTGAAGTAAACGAGAAAAAAAAATTAAAGGCACAGTTTTAAGTGTTTCCGTCTTATAAAAAATCCCTCTAAACATTTCCGGGAAAACTGATATCCGACAATTGCCGGAATTGAAAAATTCCGGCAAATTTTGATTCTGAAGCGTCTTTATCAAAAAAACTGTTGGTAAAATACAAATTTTATTTGATTTTCAAATATGTTTTTTTTTTCAGAAAAGTGAATTTTTTGCCGGGAATTAGGCAAATAATTCTGCTCATGAAAATGTTTCAAGATTTTTTTGCCACGAAATCAGACGGTTTGAGAACAGTTTTAGCGGAAAGTTAAAAAAAAATTTCAAAATTTTTGGCAATGGAAGTAAATATTTTTCAGAACATGTATCCGAACAGTTTTGGCTGTAAATTAATCAAATGTTTAGTTTTCAACAACTCTTCGCGGAGGATCCAATATTTTTCAGAATTTTGGAAATTAAAAATTTATCGAAAATAAATTGCAATTTATAAGAAAGCAGTTGTAATTTTTTTTCAAAAAGGTACCGAAAAAATCTGGCGAATTTGGCAAATCCTTGAGCTGAACAAACCCGGAAAAACGCAATCATTTTATCCTTTGACTTTTTGGATCAGGTTCAAAATTACTGAATTCCTACAATGAGTCCACGTCAGATTTTTCTATAAGCTCCGTTTGGTCTACTTGTATAAAGCTCGAAATATCTCAATGTTATGTTATTTTACTAGATTTTTTCAAAATCAATAAGTTTTTTTCGGGTAAATTATATTGTTCATTTTGTGGTGTGTGCGTGCTCTGAAATTTCACACTTTGCCGAGCTCGGCAAATGCAAATTCCCGCACACCCCTGTATTACTCACCTTCGGAAATCGCCTTACCATCTGACAGGGATGTGTGACCTTCGGCTGATACTTATGACACGATATCCGGACCACGCAACACAAGTTTACAGCTTCTCATGGAGCCATATTAACTGAATACACACTTCAACAATAAGTCCAACGGCACATGGACTGCTTCGGCACGAAATCGGTGACCAGCATGTACCTGGAATATTGGAATTGCGTGGGCAGGGTTCCTGACACTAGTTTCATTTGTCTAAAAAATTTTTTTTTAACTGCCTGAAATTAGTCCAAAATTACATGTTATCTTTTCTCAAAATGTGTGAAAATTGCACACTGAATTAATAAATAATATTACTTTTGTAAGAACATAAAAAGGGGAAAAGTCAGCGGTAAAAAAGTAAAAACACTCAGAGTTAGATCTGTTGACCTCAAAAAGTTCCATGAAAATTTCCTTCTTTTTTTTCAGAGATGTGACGTCGTAGCGGCAATTTCCGTTCGGTAAACATTTATTTTCGGCAAATACGGCAAATAGCTTCCCCGATTCGCAGTTTGCCAGTAGGATACCAATTTGCCGGAAGTTAAAGTTTTAAAAATTCCAGCAACTTAAAACTATTCTAACATTTTTGAAATGTTTTTTTACTATTTTCTCTAGATATTTTTAGAATTTACTTACTGTTCAAGCCCACAGCTTGCCGAAAATTTCCGGCAAACTGTCGGTTTGCCAAAATGGCCGGAAATTTGAGAAACGGCAATTTGTCCGTTTTGCCGTTTTCTAAAAAAATTTTCGCAATTACTGTATTAGCCGTTTGCCGAAAAACTAAATATGCCTCCCATCGTCACACAATACAAAAAAATTGCGCGGCTTCTGGAGATCAAATCTGACAGCTTACTGTACTTATAACTACAAATTCACGCTGTGTTTTTATCTAATTCACGTGGTGTCAGGGTGTCTCAGGCTTGTTCTACGTATATCTACAAAAACGGGGGCAGAGACGGAGGAATGTGCTAACGTCACTTTTTTTTTGAAAAAAAAAAAATTCCCGCATTTTTTGTAGATCAAACCGAACCGTAATGGGACATGTTAACCTGGCGCCACGTGCTAATAGTAGTCACTACATTCTTACCGCCGCTCTGATATTACACGCCGATTCTTTCCAACTTTCTGAATACCAATTACACCATTTTCTCGGATTTTGATATATAATACCGCGGGCTTCAGACTTCCGTCTCATATTTTCAGAATGTAAGAGTTTAGCGAAAGGTCATTTGGGCTAGGCTACGGCGCGTTGCAGCTCGCTTTTCTTTGCAAAACTAAATCGGCGTATCTGTCCGATTTTCATTGGAGCGCGAAAGGAAAACTAGAAGCCCATGTATTAAAAAATGCCGACTTACCTTTCGTTGATGAACTCATTTCTCCTTCCCGCTTCTTTTCCGATTGCACATGAACCTTCGTTCAGGAAACTTCTGGAATTGCTGAGAGTAAAAAATTGTTTTGTTACGAACGCGCCCAGCCCTAATAAAAATTGATGGTGTATACCACGTTGGAAATTATACAACAATACGGAGCACTTTGCTCGAAGCCTAACATTTTCTAAATGTTTTCTCACCTAAGACAAAAACTCCAAGTATTGTCGGAAAGGATACACTGTCCTCGAGACAGACTTTCGTTGAAAGTACCTCGAACATTGTGATGAGGGTATTTTAGCACGGATTGCTCGAGCTGAAAGCTGATATGTTGCTTATTACACTTGCGTGGCCGTGAACCCCAAAAACTAGGCCACCTTTTGCGCCCAATTACCGATAAAACCCCAAAGCCTCATATCGCAACAGCTCCATCATGGACAGCTCTTAGCGACTTTTTTAAGACCGCATCCACTACAGTATCGCTTTTGGCATTACTCTCGTTTAGATGACGTGTCTCGTTGAAAATAAAAAACTGAATTGTCGGAGATAGGGACGTCGGTGGATTCTACTAGCATGTTTCCAGGATCGATCTGTAAGTATTGTGCTTTAAGTACAACTACTGCTTCAGTTTGATACGCATTGTAGTTTATAGATTGTGGTTTGTGTTTTGTAGTTTGTGGAGTTTTTAGCACTATGTGTGAAGCTTGATATTCATTTTGCAGCACATTGACTTGGATTGGGGTGTGCTAAGATATAATATCAAAGTCCAGAACGTCACGAATAAAACATCTCAATCCGGAAACTACAAACTAAACCCTACAGACACTTACAAACTACAGACTATATCCTACAGACTACAAACTACAAACTAGAAATCACAAACTACATCTACGCAAAAGAACGTTACCTACCTGTTGCTTGACTGGTTTGTGTTAAACTGAACGTGCCGGTCGATGGAATTGGTGAGGAGGATTGACGCTGCTTGTGGGGCCTGGAGTTTTCAATATTTTTTTGTTTCAATTAAGAATTTCCTTAAATATACCTTACATCAAATCCCATGGCCGTTTCGGTGAATGCAGCCGAGTTGGTTATCGAACTGGTGACGTGGGATTGCACGGAATGGAGGACTGGCGGCGAAGACGAAGCATTCCTTGTGCAGGCACATTTTGCATCCTGGTAGAGGTCGTCAAATTACGGCTTCTAGGTCATTGTGGCCGTGGCCGATGCTTTAAGGGATGCTAGGTCATCTGACGTCACATTTTTTGTGGTTTTTCTAGGACACGTTACAAAGAGTTCGAAGCGCCCAATTTTCGGAGAGGTTACTAGGCCATGCAAATGTTTTTGAGGTTTCTAGGCCAGTAGAATATTGTTTCTAGGCCGCAGTAGAGAATTTTAGGCCATATCTGACGTCACAGTTTTTGGGACGCGGCCTAATAACGATGGTGGACCTCTCTTCTGGGAGGAGCAACAATACATTTTTTACGAATTTCAACAATAGAAGATGCAACTTCACTATGACCACTCATGTGGTGCGAGGTCTGCTCATTACGGTTTTATCTACAAAAATGCGGGAACTTTTTTCCCAAAAAAATGTGGCGCCGCCACGTTCTTAAACTTGCAAAATCAGTTGAAACCTCTGTGTCTCTTCTCCCGTGGCATTTTTTTTAGATACGTAGATCAAACCAAAATGAGACCACACACACACACAAAAACCACTCTGACACTTGTGCGCCTGGATGAAGTTCGTCAGGTGCCGGCAATTGCAAAGAGCACATATCTCCTGCCCATGGGAAGTCGTGACATCATGTTTGAATTGATGGTTTTTTGGGACGACACGTCCGGCGACAGTTCGGCAAAACTTGTGTCCCGGAGACGGTTCATCCTCGTCCTCGTTCCTGCCCAAAAGTGCCTTCAAATTCTTTTTTGCCTTCAGGAATCCCAACTTTCAAGCGCTTCCTTTTTGGAATGTGTTGGGCTTGCTGAAAATATTCAAAAGTTTTATTATAAGCCATAGAACCCTTACCGTGATCTTCACATCTTGACATTGAGAAATTGTTGGATGCGGTACTATTAGCTGACCTTCCGTAACATTTTTAACTTAGTGGTTGAAGCCGTAGGGGCCAGAGATTGCCGTCTATGATGGGACCTAGATCAGCTCCTTCAATGAGCTTCAACTTTGTGTCTTCCGGGATAACTGGTCCACGTCGACGGCGTCATCGCTAAAAAGGTTTGCTGTGTTACGGTAAGCGAGAATTATGGCAGAGGTGGGCATTGCCGTTCGGGAAATTTTTTGTCGAAAAATTGCCGGTTTGCCGAAAATTTGAATTCCGACATTTTGTCGGCGTAGTTTCCCAGAAATTTTCAATTCCGGCAATCTGCCGATTTGCCGGAAAATTTCAATTTCAGCACGTTGTCGATTTACCGGAAATTTAAATTGCGACAATTTGCCAATTTACCGGAAATTTCAATTCAGGCCATGCTGTCGGAAATTTCAATTCCGGCAAGACAATTTGCCGATCTGGTTTCCGGAAATTTCATATCCGGCAATTTACCGATTTGCTTGTGGAGAATATCAATTCCGACAGTTTGCGAATTTTCCAGAAAAATTTCAATTGCGGCGATTTGTAGATTTGCCTGTAAATTTTCAATTCCGGTAATTTTCGCCGATTTACCGATAAAATTTCAATTCGGCAATTTGTGAATTTTCCAGAAAATTTCAGTTCCGGCAATTTGCCGATTTGCCTGGACAATTCCAATTCCGGCAACTTACTTTACCGAATATATCAATTCGGCAATTTGCGAATTTTCCAGAAAATTTCAATTCCGGCAAGTTGAAGATTTGCCTGGAAATTTTCAATTCCGGCAATTTCGTGCCGATTTACCGAAAAGGCTCTGCAAGTCCTTCGGTAATTTGTGAATTTTCTCCAGAAAATTTAAATTCCGGCAATTTGCCGATTTACCACTGGAAAATTTCAGTTACGTATGCCGATTTACCGGCAATCTCAATCCGGCAATTTGCGAACTTTCCAGAAAATATTCCGGCAATTTTGCCGATTTAAAGGAAATTTCAGCATAATTAAGGCTACGTTCGCCGCTTTACCGGAAATTTCAATCCGGCAAGACATTTTGTTTTTCCAGAAAATTTCAATTCCGGCAATTTAACGGCCGAGTTTCCTGTTTCAATTCCGTTTGCCTGCCTGGGAAATTTAAATTCCGGCAATTTGCCGATTTGCCGAAAAAATTCTGGTACATTATTTCCTAGAAAATTTTCAATTCCGGCAATTTTCCGCTTCACCGGCGAATTTTAAAATCCAACAATTCTGGCACATTGCAGATTTGCCAGAAAATTTCAATTCTGGGAGTTTGCCGTTTTACTGGAGATTTAAATTCCGGCAGTTGCCGATTTGCCAGAAAATGATTCAATTCTGGCAATTTGCCGCTTTACCAGAAATTTAAATTTCGGCAATTTGCCGAGAGTTTTGCTGAAAATTTAAATTCCTAAGAAACTGTGACCGAGATCAGTTTTGACGTCTCTTCCAGAAAATGCACTAAGGTGATGTGACGTCATGACTGAGTTTCGAGGCACGTTTCGTTAACTTGGCGGAGGACCTAATATCCAAGGGAAATAAATTCTTTTTAAATTTCATAATTTTCTGAAAAAAAACTCACTCCTGAGAAAGTCAAGTCTCTCTTCCGGAATCATCATAAACCAAGCCCATCCTGTGTAGACTTATCACTATCTGTATCATCACCCGAAAGAGCAAAAGCCGCCAGAGAGCTCGGAGCACTCAAGTCGAACTTTGTTAGCATTGCTCGAACCTTCGTCTACGATCTATACGATAACTTCTTAACGCTCAAGGCTCCATTGCCCTTGGGAATCTCGCCGACTCGCTTGCGAACCGATGCTCCGAGATACGCAGACTGCAGAGCTATCACCGATTCTCTTATCATAAATATTTCTGTCGTTGCTTGTACTTCTTCCAATTACACTGTATCGTTTGAGCTGCTAACGCTTTTTTCCAAACTTCCGCACCTCTCAAATGATCGAAACAATCGCTTGATCTTGATAAGTAATCTTCATTCTCAAATATCGCTTTCTAGCCAATATTGTCCTGAACCATCGTTGAAGAGTATCGATTGATTACATAATGGTCCGATGCAAATGATCATCGAGAACTTTTCAGCGTCTCTCTAATAAAAATCTTGGCAATTGGTTCCATATTGAGTATTATCATTACAATTGTGCAATCGTTGCATGGGAATGTATGTACTCTTTCACATCGTCCACAGTACTATCCCTTCCGTTTCGCAAAAGAATTCGGTATTGTTGGACAAAGCTTGGATACGAATTCAATTCTCATCTCAGTACCCGGCTGTCCGAATTCGAACGGTCTCGATAGCATTCCGGTGTAGGAGCTGGCGGAGGGTTATGTTGTAGTCGTCGCAAGTGGTTAGCGATCTATAAAATTTTAGGTGGTTTTTGATAATTTCTACTTATATTCAGTCATATAAATAAACACATATAAGTACCAAAAATTTCGATCACCTAATTTTTCTTAATTTTTTCTATACTCTTACTAGTATGAAAGAGCAGGATACAAAAATAACTCCACAAGTGATAAACCAACTTTAATTGGATTAGTGTGTATCACTTTGAGTAAACTAATATTGAAGGTTTAAATGTGGACATACCTAGCCTATAAGCAAGAGAGGTCCTTGTAAGTAGACTTCAATAGATTATGAACATATTATAAACTAACGTTGGTCAAAAAGTAGGTGTTCAATGATTCCACCAATACAAACTCACCTTATCATTATTACTCTTAATACACCTTAAAATACGGCGTCGCGTTGGCCAGTGCGCTCATCAACCTCGTAGTCTCGAACTGCTTTGAAACCGACGATGGCTTCTTGGCAACCCTCCGTCCTCCGATAGCCTCCGTCAGAATTTAGCGATTTCCAAGCTCCACATTTTGTCGTCAGACTTTCCCGCCTGGGGACGCCGTGCTTGATTTCGACTCGTGTTGAACATGCTGGTATCACAAAAGTCTGGTACTTCACAGTTCGCCACGTAGAAATGCGGAGTGAACGTAGCAGATTCCGAGCCGACGAGAGACGTTACGATGTAGTCCATTACTCGGAGAGGCGGATTCTGGACATGTTGAATTATATTAAGGGCCCAAGGATAGCTCAGTCGGTAGCGCGGCTAGCATCTGGAGGTCACGAGTTCAAGTCCGCCTTCAACCCCTAGGTTCACCAAGCCTCTATTGGAAAATGGAGCAATCCACGACTGGATTATAAGCCACAGCCTTCGGCTAGGACGTGTCTTAAATTGTAGCCCAGTGGGAGCACCACCAGGTATTGTACCTGTCTCCCAGATCCGCAGATACACTCAAAATAAAAAAAATGCGAGGTGTGTACTGCAGAAGAAAACCTAATATTTAGGCCCCGACTTTTTCTCGTCCACGCATGGAGAATAGGCAACAATTTTGCCAACCAACAGGCGGCCGACATTCTCGGGATCCGCGCGCGTCTGCGCTGCGTTTAACTCTCTGTGGGCGTGGCGACCTGTCTCCGCTTGCTGCGAGTACATTGCGGCCGGAACCCGTGAGATGTCGGCGGCCTGATATTGGTTGTGGTAAAAATTTCTTGCTTTTCCGTGAGTGGACGTGAAAAAGGCGGTGCCTAAATATTAGGTTTTCTGCAGTACACGCCATTTTATTATTTTGAGTGTACTTACGTCGAAGAACGGATCGTCCTTTAATAATTGTACATTACATTTTATTTTCCCTTCTACGACTCGAAAGGGCGCATTTACGCGCGATGGTCCCGCTACCCACCCCAAAAATCAATGGGTGGCGTACCGAGACCACCGCTGGTAAATGCTCCCTCCTTTAAAGTCGTGTGGAAAAAATTGCACAAATGAAGAACCATACTTTTTGTAGCAAGTTTCGTAGTTTTTTGAGTCCGTTTATATAATATCGTAGTTGTCCATTTATTTAATGTGACACTTCTTCCCACTTACTAAGGACTTCTAACACTTATTCCAGTTATTGATTGCAATTAAATCTACGAACACTGGCCACTTCCCTTTCGCAGTTCCTTGTCGATTGCTTGAACGCCACTGGTTCATCGCCCGAAACACACTTCTCTGCACATTCCCTGTGCACCGCCACCGGATCGAATCCCAGCCGGGTCTTCATCGCTTTGAGCTCGTACTGGACTTTAGAGCGTTCGACACATCCCTCATTAGGTCCTTATTCTTTTGTATTTCTCGGAAACCCTGAGCAAATTTGTTGACGTGATGAGATGAAGACGTTTTTTTTGTCACGAAGTTGTGTGTTTACCGTAATTTGATACTTGACTTTTCCAGCATAATGGGCCACGATGAATGCCGGCTCCTTCTTCTGTGGGTGTCTCATAGTATCCGTTGTTCTGGAAATTTAATCATGGAACTAGGCATGTAATAAGAAACATTGAATTAAGGTATGTCCCGGAGGAGTGACCATCTTAGGCCTGACTTAAACTAGAAGTGGATCCAAGTGGCAGACTGGCCTGAATCCTAGTAACAGGCTGACCCTAGATGATTAAAGGTGGATTAGCGCCAGTGGGAATTCTGTATAAACACACTTATAACGATACCAAACGATCGAATATCATAAAACACGCCAAAAACTTTTAGATTTTTCAAATTTCCGGTCAAAGTTTTTGGAACATTGACAAAATTTTGACGCCAAATCTGAGCTGTTGCGGACATCAAAATCAATGTAACATTTTTCTGGTCCCCTACAATGTCTTTTTACGAAAAATTAAAACAAACCAGATTATATAACAAATAGAGAAAAAAATATTTTTTAGTCGAATTTGTGTCACTTTTTGACTGTAAATAAAAACATTTTGAAAAATTTTTGAAAACTAGTTTTATCATGAGATTTGGTCATTTTGGGAGCATAGGTCGAGTGGTTTTTAACAATTTCCACCACCGGCGCTACTCCACCTTTAATCGATAATCGATGCATTTCATACCTTCAAAAACTGATTTAACTTCGCCAGCATTGAGTCGTCTGTTCCATTATTGATATTACTCTCCTCATCGACTAGCCTGAGAATTCCATATGGTTTACTCTGAAAATTCATCTTATATACATGGATATATATATATATATAAATATATAAATATATATATATGCATAAATATACATGTATATATATATATATATAACAGTATGGGAAAGCCATAGGACACCCCCTAATTTGAAGGTTTGAGGAACTTCCGAAAATTTTTTTGAAAAACTGCTAATGCCATTTGTTTTTAAATTGAAAAAAACCTATAGATTTTAAATTTACAAAAAACTTAGGAGGTCGCGCTGGAAAAAACGTCAAAATCCAGTATGAAACTTCTATAGGACCCCCCGTAGGGGTTTTTTTCACGATTTTTCTAAAATCAACTGGCATATTTTGGAATTGACAAAAGCTCAAATCAAGTTTGAGTTAGCAATGAGTTCAGATAAGCAGTTTTGACTTTAAAAAAGTATTACGAAATGTTCTCGTGGGATCTCCAGACTGGTTCTGATTCTTTCGAACTATGTTAGTCTGTTTCAAGCTTCCTGGTGCTCTCGGTAATGCCAAAACTTGATACACACTCTTGAAGAAGTTCCTACTAAAATTCCTAGCACACACACGCTGGCATAAAAATTTTTACGCCATCCCCAAGAAACCAGTCAGAACGCTAACAGCGGATTATAAAGCCAAGTTGCAGTTATTTTTGATCAACAACAGAATATTCATCTACTAAAATCAAGAAAGGATCAATAGTTAATCGTGTTTCCTTGTGTGCGGATGATCTCAAACAGTCTGTCCTCCATTGGTTTGACCAAACTTTTCAGCTGGTTGTCCGGAATAGTGCGCCCAGTCGAGAATTCCTTGCTTCATGCATCTGTTGAGTAAGTCTTGTTCTGGAATAGCATAAACGATACGGACAAGAATCCCCCACAAATTTTCGATTGGATGAGATCAGGACTTCGAGCTGGCCAATCAAGAAGGTTGATCTTGTCGATATGAGCTTGAAATAGTCGCGGGTTGAGTTGCTCACATGGATTGTCGCATTATCCTGCTGAAATCTAAAGTCTTTGCTGGAGTGGTCTAGAGACGAAGATACTTGGAGAGCTCTCTCAGTTCCAAGACGTTCTGATAGTCAGTGCTGTGCATCTTGAACGCTACTCGAACTTCTCAAGCTTCTTCTCCGTGAACGCTCCCCAAACCATCACCGTTCCTCCTGCAAAATTACGTCTCGAAAAAACCCTTGGTTCTTTGCGAAAATCCCGCCGTACACTCGGGAGACTACCGTCAGGCCCATCGAGATTGACTTTCTTTTCATCGGAGAAGACAACCTAAAACAATGATCCTAATTATTCACTCTTGCTTTCTTTAAATTCTCACTTTACTCCAATTCCTTCCCATATTGTTACTTAGCAAATTCCAATCGCTTGGACGAGTTTATGCAGAGAGTAACGAGCAGGGCAAACAGTTTCTGACAAACTATTACACCAGATCGTTAGATGACATTGAGGGTCGAATGGTCCTTTTTGAAGCAGACAATTGAAGCTCATTGCGAATATCTCTTGCCGTCTTACAGGAGTTGGAGGCAGCAGGAATAACATTTCGCTCGCATTTCAGGCACGGCGGAAGAGACCTTTGCGACGAGAAGCTCTTTTAAATGTACCGCGACTTAGCTCACCGGATCCCTCAGATACTCGCGAATACAGTGTCGAGAACGGGAAATTTTCCTACTCCAATTTCATGCAGGGACACATTAATTTCATAACATCCAACTGAGCGCGTTCAGTGTCCGAAAGGGCAGATCGTCGCTCTAGGTGCAAGTAAGACTGCTTTCGAAGTATGCCTATATGTGTGCCACAACACATGCCACAATTCCACAATAATACGCAAAAAATAGTAAATAACATCTGTGAGGGACAATTTAATCTTGAAATATTGTCCCATGGAACCTTGTACTTAGATCAAAGAATAACGATTTGATTCCTGATAAGCGTTCCATTGTTTCGTGCTGCATATTTTGCCAAATCACCTTGACTCCACAGACGAAACATCTAAAGTGCGTGCTAGGTATTTTAGTAGGAACTTGTTAAAGAGAGTTTATCAAGTTTTGGTACCCATTACCGAGAGCACCAGGAAGCTTGAAACAGACTTGAACATCAAAGATCGGAAGAATCAGTTGAGAGCCAGTCTGGAGATCCGACGAGAACATTTCGTATTAATTTTTTAAATTCTGACAAAACTGCTCTCACCTCAATTCTAACTCAAACTTGAACATTTGAGCTTTGTCAAAATTCCAAAATCTGTGTGTGAATACATTTCAGTTAAAATCGTGAAACGGGGGGTCCATTTATAGAAGTTTCACGCGCACTGGATTTTGACGTTTTTTCCAGCGCGACCTCTGTTTTTATAAACTGCTGGAACAAAATCAGTATATAGGTTTTTTTCAATTCAAAAACGAATGGAATTAGCAGTTTTTCAAAAAATTGAACTTCGTCACCCTTAACCTTCAAATCAGAGGGGGTCCTATGGAACTTCCCCACACTGTATATATATATCTATATATCTATATATATATTACGTTTGAAAAAACCCAAAAAGGAAACTTATTGGACTTACCTGAAACAGCTGCACACACTCCGTATTATCAGTATACTCGATATTGGTCCAAGAAATCTCCTTCAAGTACTCCTCTTGTTCTACAAAAAGTGGAAAATATGTTGATTGAAATAGGACTGAAGTTTCTCAGTGGCATCGTTGATACATAACTGGCTTCAAAGCTGTTGCATGGAGACCCAACGTCTTCAAATTCCGAAATATATCCTAGATACTTGAAAATTACTTCAATTTTTAACAATTGATACTCATTAATCTAACCTATATAATATCATGTACCTCCCAGCTTATTGAGAAGTCCTTCTTCAGCAATGCCTTATTAATCCTGAGGATTAAGTGAAACAAAGAGTTGTATATGCACATCCATGGCAGTCTCGGGTGTTGGTGGCGAAATTAAATTATCTTAAATTCTCTAATTTCACTTCTGTATATATATATATATTACCTCAGACACTATATCGCAAAACTACAGTTTCTGTCTTCATAACATGTCGTTTCATAGTTAGAGCCTGCATGGGTGTCGGTTGATGTGAAGCAGATTTGCGACTAAATCCACGACTTCTTCATTTTCAATATACCCACGTTCAACGCGGGCTATGGTAGCCATGTCTCTGGAAAATTGCATGGGAAAAATAAAAAAATTTCAAGATGTTATTATATTAGGAATCCTCTAAACAAGTGTTTTCAGGTTTTTTGGTTTTACGATTATTCAAATTTTTATGATTCGGAAATTATTATAATTCAAATAATTTTCGTCACTATTATAGCCATGTTGTTGAAATATAGAATGCTATCTTTTTAAAGGTGGAGCACCGAAATCTGGAAACTATTTTTAAATGAGTCCAAATTTTCCCGATTCCGAATATCTATGCGAAAAAATTTTAAAAAATTCATTTATCGACTTTTTCAAATTTTTCAACCGGCGAATTTTCGCGCCAGAAACCCCGTGTACACGTGGTATCAGTGTGTCTCATTTTGTCTTGATCTACGCAGATAAAAAATGCGGGAGAAGAGACGCAGAGGGGGTTCTCAACTGAGTTCGCATGGTTAAAAATGTCCTGACATCACCTTTTTTTGGCATTTTTGATCAAACCGGATTTGGAGAGCCTCTAGGCACCACGTGAGTAGGCAGGCATTTTTTGCCTGACTACTTGCGGGTGCCTGCCGTTTTTTTCTCCTCAGAATTTTTTCGCGAAACTCAATAATTCAAATAATTATGAATATTTTCGAGTGAAGCTTTAAAAAGTTGTTTGTGCCAAGTTTGAGTTCGTAAATTAATTAGCAAAAAATGTTCTCACGTCACGTTTTTGGGCAAAAAAATCTCGCATTTTTTGTAGATCAAACCGCAATAGGACAGCCTGGCACCACGTGCGTGTGTCGATTTACGAGATTTGTGTATATTTACGAAATTTTTTATCTTTATCAGACTCTGATTTTCGTTTCTCAACGAGTTTTCTTCATTTTTGTATGTGATTTTTTTAAGGTACATTAAATATTTTATCATCAAAACCCTAGCAAAATTTTTGGTTTTCAGTCGGTAAAATCATATAGGTAATTGCATTTGCCGTCAATTTGTGACCTAATAGTAAGCATCGGAAATATTGCCAGTTTTAAATAATTAATTGACCCTAAAACACACATTACAAAAAAAAACCGATAAAAATTAAAAATTAAATTAATGCACAAATCTAACGACACATGGCTCTAGCGCGAAAATTCAATAACTCTGTACAAATAGCGATTTCAAGCTCAAATATAAAATCGTGGAATTTTAAAAATTTTTTGCACATAGGTAGTCGGAGGCAGGGGAAATTTGGAGTCAATTAAAAATTGCAGATTTTACGGTTTCGGTGGCGCTCCGAAGAACTGTCTGAATAAAATTAAAACTTTGGGAATAGGCAATTATTCGGTATGGTTAACTTTTGCTCTTGGTGAATCTAAACCGTCCCAATCATTTACCTTAATATATGTGATATTGCCAAGAAGCAACACTGCTGAAATAATCCCGAAGAAGGTCTGCTGGGTCTTTGCATGTCCAAAATCCGAGGGAGCTAATTGCATGCCTCAACCTATCAAGCTCATCTCGTACACACCTTCCAGGCAAATGGCTCGTTCTGGAAATTTCATTAATTTTTTTTTAATTTTTTAAACAAAAATCCCTTTGAGGTCAGCGAATGTATCCCTTATTCGCTCCTGTGAAACTTTTCCCAGCTCACCTGATTCAAATACTTATAATCATGTGGCTTCAACAAGAAATATTTCTTCCTTTCTTCCTCGTCTGGACCCTCCAGAAGGTAGTAGCATACGTGGTAGTTCCTGAAAAATATATAAGTCCAAGATGGAAGACTCCAAGGGAGTTTAGGTAATCGTCCGTTCTCCTTTAGTTTGAAATATGATGCGTGATTTTTCCAGCTACCAGGTAGATCTCCACGTTTGCTCTGAAAACTCCAAGTATAAGGCCTTTTTTGTGGTATACACATCAGGAGAAGGCTTCAAATTTTACGTTCGCTAGGTCAATTTAGGTCATAGTGCCTAGTAAGTAGGGTACCTATAAGCTGTGATTACTGCCAAAGTAAAAATTTCCCGATTCCGGCAATTTGTCTGATTCGATGCCAGGCATCCCAATTCCCGCAATTTGCCGATTAGCCAGGCATTCTCAATTCCGGCAATTTTCCAGTTTGCCGGATTGCCGGAAATTTAAATTCCGGCAAGTTGCCAAATTTCTTTTTCGGCAATATACTGGATTGCCAAAATGTTACGGCAACATGCCAATTTGCAGGAACTCATGTTCGGCAAATTGCCGGTTTGCCTATATCCCAGAAATTTTCAGGTCCGGCAAGTTGTTGATTAGCCGATTTTCGGAAATTTCAGTTCCGGCAACTTGCCGATTTGCCGGAAATTCTCGAAACCGGCAATCGCGGGAAATTTAATTCCGTCAAATTACCAACATGCCGGATATTTCAATTCCGGCAATTTGCCAATTTGCCGAGCATTTAAATTCCGGCAATTTGCCGAAGAAAGTATCAATTCTGTTGGCAATTCGCCGGACATTTCCGACAATTTGCCGATTTGCGGATTTCCCAGAAGTTTTCAATTCGGTCAAATTTCTAATTTGCCGGAAATTTCAATTTTACTAAGTCGCCTGCTATCCTCCTAATCTCACCACACTCGGAAACCATTCCATTCTCCCAAATAGTTGATTGTGATGAATTTTCCAAATCTGCTACTATTTTTGTACCGTCGTTAAGGGGACAGCATTAAAAGCCTCTAGAACAGGGCCAGGTGACAGAAGGGGTGTCTGCTAAGTACTGCAGCCTGTTGAACCTTTCGCATGACACTGTTAGCGATATCAAATGGGAGATCAGATGATTCGTGCAATGACCGTATTTCCCGAACCACCCCGGGAGATTACCACGCATTGATTTTTCTTGAGTACGGAGAGAGCATGCTGAAAAACTTGTTATGTGGTTTAAAAATTAGTAGTGACAGTTAGTTAATCCAGCATCTGCAATGTATATCTCTTTTTTTTGAAATCAAAAGTGCTTTGAGGGTGTTGAAAAAACGAACACATACCTGCTAAAAAATTGGTGGCTTCCGAATAATCCGGCCCTTGGCAAATATACAAGCCAATACACAAAGTGAGCACCTACGTGGCCGAGTGAAGAGAAGGCCACCGATTTTTTTGTGGTCACCTGAAACTTCAAAAAGTAACTGGGTTCCCCTGGTAAGAACGTAGAACTCACTTGTGGTAACAGACTTCGGCGATTGCAAAAATGTGCGGTGGTAGTGAGCCGAGCCGCTTACTTTGAAAGTTATCGCCTGCTATTTTGGGTTGTAGATCGGAAAGAAGCAATACGGAGCGGGTACACGCTACTAGAACTGGACCGATGTACGTATAGTAAATATGCCCATTCGCGAATCATTGCATCCCGCAAATTGTCCAAGAAAAGAGGTTTGCTCCGTGAGCTCAACTGGCAAGTGACAGAGTTCGGGGTACTCCCTGAAAAATTTTAAGGGTTTAAAATTTTTTTAAATATAAAAATATTTAAAGGTGGAGTACAGGAAATTTAATTACACCAAATTTTCCACTGACTCCGAATCTGTAAGTAAAAAATTTTGAAAAAATTACCCTGATTTTGTGTATTTATGTTTGAAATTACTATTTTCAACCCTTTGTGCCCGCACCACTTTTTTCAAACTTACGCCCAAAGACTGATACGTAGATCGGGTTTGCATCGTTTGATTTTCGTCGTTTAATTTATTTATTTTCCACGGGGTTGTGGCCCTCACTTCTTCATTGACGGCATTTTCGCGCTTCATTGACAATCGCCTGCCGGACAACACATGGAAAAGTGTCGTGTACTCCACTCGGACAAATCACATCAGTTTTACAACTAAAGAGCCGCGACGCGACACGCAATTCGCCGTAAGCCTACAAAATCTCTCCGACCCAAAATGGCCTAGTTCGACAAAGCAATTCCGATTTATGAGGGAAGCCAGTTTGTGCGGCGAATTAAATTTTCTTGAACCAGTTTCAATCATTTTTGTCGAGTTTTTGCTAGTTTTTTTTTTGACAAAAAAATGAAACTGGTTAAAAAAATTTGACAATAAACAAAATTTTTAAATGAAGGAAATCAAAGCGCCCTCCAATGCGGATTTATTTGGGTGCTCATTTGACATCACAGAAAACACGTGGTGGCAGAGCAAGGATGTCAATGTGAGTCCCGTAAAATTTTCGTAAACGGGACAACGGGAATTCCCGTTCCCGTGAAAATTTTAAAAACGGGATAACGGGAATCCCGCGGCGTTCCCGTGAAAACTTAAAAAACCGGACAACGGGAATACTGCTCCCGTTTTTTTGAAAACACTCAAGAAAAACGGGACAAACAGGGCATTGGTTTAAAAAAAAGAGTGCATAGTTGGCGTATTTAGTGTCTTCGAGGCAAATTATAAAAAAAAACTGCATTATAAACATTATTATCTATTTTTTCATTATTAAACAGATATTTAAAAAGCCAAATGAGTCGGAAAATGTCCCGTTCCCGTGAAAATTTTAAAAATGGGACAACGGAATACCCGTTCCCGTGAAAACAGCCCCAAAAACGGGACAACGGGAAAAACGGGAAGAATTGTACACTGTCCTTGGTGTCGAGGCTGTCTCTTTATCTACAAAAACAGGCTGGAATAGTTTTCCAGAAAAATTCTAACGTCTCTTGACTATAGGGACCAAGCGAAAAAATGTCCGCGTCTCTTCACCCGCATTTTTTGAAAACAACAAAAGAGACCGGGCTGCAACAAATTAAAATCAGGGAAAATTTTTTCAATTTTTTCACATCTAAATTCGTGATGGGGGGGCAAATTTGGAGTGATTTAAAAATATTCAGATTTCGGTACCCCACCTCAAAACAAAATAATGAAAGAATTGCCTTACCCGTGGCTGATCCCAGAAGTTCGTAAGAAAAGCGTCAATCGATGAGGCGACCTCTGCACTTCCAAACCGAGCGCCGCGGGTTGCCGCCCGATAATCGGCCGGTGTCAACATATCGATTTTTTGGAGTGGCACTGTCCACCACTACAGGCAGCCGACCAGAGGCCTGTAAACATCCGCGACTGGGTATGTTTCCCCGGGGTATCCCTAGGCAGCGTTCGTTATAGATTTCTTAGACCGACGGTGGGGCCCATCATTTCGAAGAGGTCAAAGTCTACCGACTGGCCTCCTAGTTCTGGAAATTTTGACTTTAGAAAAGAAATCATTTTTTTCCATTTTTTTTTAATTAGCCCGTTGCTTTTTTAAAAATTAGAAGAAAATGTGAAAAAACTTTGCATTAGAGCGCGTTTGCATTCATTCCATGCAGTCCAATTTTGCTGGGAGCTTGAGTGTCTCGACTTGATCTACAGAGGTCTCTAAAAATGCGGGAGAATAAAATCCACTGATATTGTATGCCTTTAAGAATGTGCTGACGTCACATATTTTTGTGCAAAAAATTCCCGCATTTTTTGTGATCAAAGGCCATGAGGGGACAGCCTGGCACCACGTGAGATTGTGTCGACAATTTTTTGTTGAAGATGTATGGCCAAAAACGGCACATTTAAGTAATTAATCAGCAGAGCGCGTTTGAAATTTTGTTAAAATCTTTTTAAAAGAGTTCCCACTTCCCGAAGTCCTCCGATTTTTCTAAAAACTAAGAGTAGGGAATCTCCGACCCTGAGCCTTCTTTAAAACCTTACCAGCTCTGCCCGGAGAGCACTTTTTCGATGAGTCCTCCGTCGTGCGCCGATCATGAACCTGCAAGTGTACTGTATCATTTTCACAGAGCTGTCGGGATTGAAGCTGTGCATAATAGACGGCTAACGTATGTTGCATCGACTGTCGCGTTGGTGAGCACGTTGGGGAAAACACCCCGTCGCTCCAGCTGATATTGAGTCAAATGACATCATTTTAGTGAATCCAGCATCGGGATGAATACGTCTGTAAAAAAAAATTTTTTTTGAAAGAAAAAGTGCCTGGAGAATCAGGCAACGAACCGGACAAAAACACAAGACCGCGAAAAACCAATTGGTGGCCGAGTTTTCTCTCTCGCGGTCACTTAGGAAATACTAAATTCGCACGGATTTCTGGCTTCTCTCCAACATAAATTGAAATGGAAGATTTTCGGCCGAACTAGGCTAACTCCGGGCCCTATCTGGTGTATGTTTCCGACTTTCCCACGGAGCGATTGTCAATGGAGCGCGAAAAACTCACTGAGAAAGGCCCCCCGTGAGATCGAAATGAAAATTTGCTAAATGGCCGAAAATTGAATACTCGGCCGCCAATTTTTCGACACGGCCACAGGATAAATCGTAAAAAAAATTGAGAGAAATTTATTAGAAAAAATCTGAAAGTAATGTTTATTGCACCGTGGCCGCAATTAATGTAAAAACACGGCCACTTTTTTAATGTGGGGAAAAGGTTGGCCGAGTATTATACAGTTTTTGCGGCCACTTAGAAAATATTTAGATCGAAGGGAAGTTGAGAAAATACGTCTAACGAAAACCAGTCAATTTTTGTTACATGACCGAAAAATGAAAACTCGACCACGGATTTGTTATGCTTTATAAAAATTTATGAACCTATTATTTTTTGATTCAGAAATCTTTAGAATTGTAACAAGAAAAAGTCGGCATCTTTTTTTCTCACGGTCGCAATTTTCTTTGTGATCGTAAAAATGGAAGCTCGGCCATGGTGGCCGAGTCCCTTTTTTTTCGCTGCCTACTGGTAACACGTGGTTGGGTGAAGAGAAAACTCGACCACCGGTTTTTTTTGTCACTGAAATTTTTCAATTTCAAAATATTTTAAATCTTGCTGCACTCTTTCAGCACAACCGCGAAAAAATGACAGCTCGGCCACCAATTTATTTATTATCTGGGTGAAAAAATTTTGTTAGCCAAGTTTTCTTCATCTGGAAATCAAAGAGATTTTTGTTACGTGGCCGTGAAAAGGAAAACTCCGCCACCAATTATTTTTAATTTCAGGCACTGGCGTTGTAAAATCTTATAAAAAAACAGGTTTTTAAGTACATTGAACTAAAAAATAAGGAAGATTTTTGGAAAAAAAATTGCTGGCCGAGGAAAACTCGGCCAACAACTTGTTCCGGTCACACAGCAAAATCTCTCGATTTTCGATGATTGAATATTGAAATCTGGGTTGGATTTTTTAGTATCATTTCATTTGGTCGCCGGTGGAGAAACGAGGGAGAGAGAGAAAAAAGATTTGTAGTGTCCCGGGAATCTTCCTCAAGTGTTGTGGAAGAAAGTGGAAGAAGCTTCTGCGCAGCAGCAGCAGCGTGGAAGTGGTTCACGAAAGAGAGAGAGAGACATGTTGGACTTGAAACCAGCATGATGAAAAATAAGAAGATGAAGAAGAGAATTACACACTACCTCCACAACACAGATTATTTTTATCACGTTTTGAGGGGGCGCTTCACACAATTCATGGCCTAGAAATTAAGTGGTAATTTGGTGGCCTAGAAAATACTATATTTATATTAATTATTCTACGTCAATAATTTAAACGGGAAACGAAATTTATTTTAAAAAAGCCATAGAAGAGGTTTTGAAATTGGCTAGGAAATGAAAAATTGTGTTTTTGGAATTTTCTAGGCCCATTTGAACTTCTCCTGAACACTGCGCTTTCAAGACTTCGAATTTGAATTGTGGCCTAGAAAATCATAAAAACTAGGAAATCAAGAAAAAAACATGGATGAAATTTTGAATTTTATAGGTCATTTGAAATTTCTGGCCTAAAAAATGAAAAATGATTTTTATTTTGAATTTTCTAGGCCACTTGAATTTCCTGACGTCGACAATTTTCATAGCCTAGAAATTTAAATGTGGTGGCCTAGAAAATAATTAAAAGTAAGTAATCGAGAAGAAACGCGTGAGATTCGGAGTTTTGTATTTTCTAGGCCATTTGAATTTGGTGTTGGACATGAAAAGCCAAAAAGACTTTTCAGGAAATTTCTAGGCCATTAGAAGTTGATTGGCCTAGGAAAAAATTTGTGTTTTTGGCATTTCCGTCTCTAGGTCATTTGGATTAGGGCCTAGGAATTGAGTAGTTGTTTTGGAATTTTCCACCCTAGGCCATTTGAATTTGGTGGCCTAGGAAATGAAAAAAATATTTAAAGGAATTTTCTCCATTGAAGTAGATGGCTTGGAAATAAAAAAAGGTTTTTTAAAGGAAATGTCTAGGCCCTTGAATTAGTTGGCCTAGGGAATGAAAAATGATTTTTTGCTTAAAATTTTTTAAACGCACTTGAATTTGGACGGCCAAGGAAATGAAAAATGGTTTGTTGAGTAACTTCTACTTGAATTTGGTGACCTGGGAAATGAAAAATGATTTTCTTGGAATTTTTTAGGCCACTTGAATTTGACGGCCTAGGAAATGAAAAATAGTGGTAATTTCTAGACCACATGAAGCGATTTTGGTGGGGAAATGAAAATGATTTTCTTGGAATTGTTTTTAGGCCACTTGAATTTGAGGGAGGAAATGAACAACAGTTGTTTTGGAATTTTTTAGGCCACTCGAATTTGACGGCCTAGGAAATAAAGATTTTTTTGGTAATTGCCACTTGAATTAGGTGGCCTGGGAAATGAAAAAGATGATTTTCTTGGAATTTCTAGGCCATTGAATTAGGGGGCCTAGGGAATGACTCCAAAAATTATTTTCTTAAGATTTTTTAAGCCACTTGAATTTGACGGCCTAGGAAGTGAAAAAAGGTTTTTTGGTAATTTCTAGAAGGCCACTTCAATTTGGTGACCTGGGAAATAATGATTTTCTTGGGATTTTTTAAGCCACTTGAATTTGACGGCCTAGGAAATGAAAAATAGTTTTTTGGTAATTTAGAGGTTGAATGTGGCCGTGGCCTGAGAAATGAAAAATGACTTTCTTGGAATTTGTTAGGCCACTTGAATTTGACCGGCCTAGGAAATGAAAAACTGTTTTGGAATTTTTTAGGCCACTTGAATTTGACGGCCTAGGAAACGAAAAATAGTTTTTAGGTAATTTCGAGGCCAATTGAATTCGGTGGCCTGGGAAATGAAAAAAGATTTTCTTGAAGAATTTTTTAGGCCACTTGAATTTGACGGCCTAGGAATGAAAAATCGTTTTTTGGTAATTTCGAGGCCATGGCTAATTTGGTGGCCTGGGAAATGAAAAATGATTTTCTTGGAATGTCATTTTTAGGCCACTTGAATTTGACGGCCTAGGATAGTTTGTAATTTCGAGCCCACTTGAATTGGTGGCCAAAATAATGAAAAATGATTTTCTTGGAATTTTGACCACTTGTGATAAATGTGACGGCCTTATTAGGAAGACGCATGAAAAATCGTTGGTAATTTCTAGATCGCGAATTTGACGGGCTAGGAAATGAAGTTTTTTGGTAATTTCTAGGCCACTTGAATTTGACCGCCTAGGAAATGAAAAATACCAAGGTTTTTTGGTAATTTCTAGGCCACTTGAATTTGGTGGCCTGGGAAACGAAAAATGTTTTTCTTGGAATTTTTTAGGCCATGAATTTGACGACCTAGGAAATGAAATTGTTTTGGAATTTTTTAGGGCACTTTTGGGTTCGCCTAGGAAATGAAGATTTTCTTGGAATTTGCGAGGCCAGCAGACTTCAATTTGTTGGTCTTGGGAATAATGATTTTCTTGGAGTTTTATAGGCCGCTTGATTTAAGCCCATGGCCTAAGAAGTTCAAAATAGTTGTTACGGAATTTTCTAGGACATTTGAACTTGGTGGCTAAGGAAATGAAAAACTTTTTTGGAATTTTCTAGGTTTCTGTAATATATGATTTATTCAGTTAAAAAATTAAAAAACATTCAATTTTTTTTAAATTTCGTGTTAAAAAAAATCAAATTTGCCCAAAACTTAAAAAATAAGCTAAAAAATTGTAAGACGATACAGAACGGCAAAAACTTGAAAATAATAAGCGTGATGAGCCCTGTCGGACGTAAGGGCCGCCGGCTGGTTCGACCTTCTTTTTCTCTTTTTGTTACTCCTCTCCCGTCCCGAGCAGGAGCAACACAACGAGAGCGCACAACAAGAAGAAAAAGCAGATAGATATACTTAGATATAAGTTGTCTTCTGTTCATATTCTTTCTTTTAGACATCTTTTCATTCGAAACAACACTCCATTCTCTTCCGTTGGACGGGGGGGGGGGGGCGACGCGGGAGACGAAACAATAAAGCAAAATTGGGAGGGGTTGGAGAATGTTTGGACAACAAAAAGATTGACTGATCAATCGATTCGCCAGCCTCGGCTATTTTCGGAAATCGGAGCTATGCAAATGCGCCCTACTGATCAAATGGACGGGTGTCATTTAAACTCCTTGGTTAAAAAGCAACGCAAAATGGCATAGTTCCAGTTTGCCGATTTGCCAGAAATTTTCAGGTACAGCAATTTTCCGATTTGCCGATTTGGCGGAAATTTCAATTTAGACAAATTGGCGGCTTGCCGAAATGCCAATCCAGGTCCGCCAATTTGCCAATGTTGATTTTTGGCAAGTTTCTGGTTAGGCGTTTTCATTTTCGAATTACCGTTTTGCCTAAACGCCAGAAATGCTAAGGTTCTCTAAAGCGCTGGTTTTTCCCGTAAAAATTTTTCATTTTCGGCAAATAATTTGCCGGCTTCCCAAAAAGCCGGAATTTTTCAGCCGGCAATTTGCTGAATTGCCGGGATTTTTTTTTCTACAAATAGCCGGTTTGCCGAAACGCAAGAAATGCTCAGAACCTTTGCCGATTTGCCGGATATTTTGATTTTCGGCAAATTGTCGGTAGTTGCCGATATGCCAGAAATGTCTTCAGGAACGGCAATTTGCGGAATAGCCGGAATTTTTTTTTTTTGGCAACGATTTGCCGAAATGCCAGAAATGTTGCGGTCCGGCAATTTGCCGAAATAAATGTTCAATTTCGGCCAATTTGCTGATTGCCGGAGTTAAACAATTTCGGCAAATTGCCGGCTGGTCAATGATGCCGGAAATTTTCAGGTCAATTTGATGATTTGCCGAAAAATTTATTTAAAAAAAAAATGTACCTATTTTTCTCCAGACAGGAAGTCTCTAAAATCTCATTTAATAAGAAGAAACAAAAGAGAAACAGAGAATGGCCTAACAAGTTTCGAGTTACAGAAACCTAGGCCACTTTGAAGGCACCGGCGTAGCCTAGAAACCCAGTTCCACAAAAATAAGAAAAAATTAAAACTCGGCAACATAATCTAGGCCCGGAGCATACAAACACTCCACGAATATTAAAGACTCTTTCTAGGTTACTGGATACCGTTAACGATGGAAAACTCGGCTCGGCCATCTGCGAATTTTGTTGCTTGAAAATGGGAAAAATAAAGTTTTTTTAACTTACGGTCAAACAAAAAAGATCAAAAAGTGAAAAGCGGGGATTTATCTTATCACACAATTTATGACATAAATCCGTAGGCCGAGTAGCGGAGAGATCTCGGAGCTCAATGTTAGGAATATCTATTAGGACGACACATCATACTCAGCCACCCCAACCCAGTCATCCCACCGTTGTCCACTGTCTTTTTTTTTCGCTTTTTTATTATCAACCAGCAATAACTTATCGCCTTTATCTTTGTGAGGCCCCGCGCAAGAACGAGACAGAGAGAGAGAGAGCGAGAGAGTGAGAGACAGAGACGCCGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAGGGATATAGGTGCAGCGGACAACTAGACGTCACTGGGCTCTTTCACACATGTGATATTGAACGATAAATTGCGCTCCTAGGCCACAAAAAAACAGTGTATTCGATCTCATGATATGGGAGAAGCTGGCACCGTGCCAAGTTTCAGAAAAAATATGGAATTTTTGCTTGAAGCATGGTGAATCAACGTGCTTACACAATTCTTCGGGATAAATATTCCCGCATTTTGTAGATCAAAACGCAATGAGTCATGCTGATACCTGAGGTTAATTAAAAGTACTGATCGAGATTTTGAGCGTCATATGGTGTATTTACCGGCAAACCTGATGCGCCTGATTTGACGCGCAAATCCTTCATTTTAATAAAGTTGGGCTTCAAATGTGATGCCTCAATTTCTATTTTTTGAAATGTTTTGATTTCGTGAAAACTAACGGCGAATTTCAGAAAATTTATAGAAAATGTTCATTTGTTGCGACCAAAAACTTAAAAAAGACCAAATCAGGAAATTCACATTTTTCGCCGAAAAAACCATTTTGCGCGTAAATTCTGATGTAATTTGCCGTAGGCTATTACGTGTGAAAACACTGCCGGTAATACGTTATATGCTTGAGCGCACCCAAACAAATCTCGTCCCAAATTATTCCGGTTGCACAAAATTCTGAGAATGCGTAAAGCGCAACATACCTGACGCGCAAAATATCTCGAAGTGGAAACTACAGTAATCCTTTTCAAATGATTACTGTAGCGCTTGTGTCGATTTACGGGATCTCGACTTTCGAAATGGATTTAAATATATTATTTATCAATAGAATATTTCAAAGATGAAGAAGTTAATTTCGTGAAGCCCGTAAATCGACACAAGTGCAATAGTAATTTTAAGAATTACTTAGTGTTTCGCTACGAGATAATTTGCGCGCTACTCAAATATGTTGTGCAGTACGGGCATTCAGAATTTTTCGTTCCCTTTCACAAAAATCTCATCGATAAACTTGCGCGTAAAATTTGGTGGTGCCTGTGAGTGGTTCACCTATACAAGTGGTGCCAGGGGCTGTCCCATTACGGGTTGATCTACAAAAAATGCGGGATATTTGCACAAACCATGCGATATCAGTTGAGAACTCTGCGTCTGTTCTCCCGGATATTTTGTAGATCAACGTAGATCAACACTCTGACACGCACGTGGGCCGAAGATGTAAGTGCCAGATTACACGGCGCAAAAACTGAAAAAAAAAAGAAGCGAAAACTGTCAACGAGCATTTGAGCGAGTTTTTTATCATCCACGAATCACAAGAAAAATCAATAGAAAATCGATAATCAAAAAGTGAGTATCATATTTTCGACCAACAGAATCATTCCAGGTTCATCAGTGAGCATTGTTTTCAAGTATACGATGAGCCAACGACGGACACGTCCCGTTCTCTGCCACAAGTTCGCCAATCTCTTGAATAGGCGAGTAGCCCATTTTCGAGTATTTATCGATTGCGGCAATCGGATCATTAACGTTCGAGAGCACGTCGCTGAGCATCCGACAGCCGATGATTGTTTTGAGCATTTCACCAATCCGTGACGATTTCCGAGCGACTTCCAATCACAATTCCCAAAAAATCATCGGGGTTTCATGCTTTTGATTGATCTACAAAAGAATGCAGGAATTTTTTGCCCAAAAGATGGTTATGGACATCGTCAGCACGTCTTACTTTTAACCATGTGAAATCAGTTGAGAACTCTGAGTCTGTTCTCGCGCATTTTTTGTAGATCTGCGTAGATCAAGCCGAAGTGAGACCTTCTGAGTCTTGACACGACAAACTCCCATTACATACGGATGCTGAGCCTTTGTTGGATGTGAGAGAGTTTCCAGGTTGTTCTCGAAACTTTGCTTAAAATTTCATTCATAAAAAATCATTTTTTAACGAAAAACTACTAAAAATCATCCGATAAACCTGGAAATCCATGAAAAACTCTGTGACAAATACAGTACTGTTTAAAGGCATAGTGTACCCAGTCTGTGTTCTGAGAATACGTATTACACAACATATTTGACGGGCAAAATATCTAAAACCGTCTACAGTAATTCTTCAAATGACTACTGTAGCATAGGCGCTAGTGTCGATATACGGGTTCGGCTAGGTTTAATTTCTTACGAAAGCTCGGAAATCGACACCACCGGTACAGTAGTAATTTTAACGGCTGAATTACTAGTTATATTTTGCGCGTCAAATTTGTTGTGCTGTACGCAGTCTCAGAACTTTGCGTTTTCGTGATTTTTTTTTTCAAATTTTAACTGCGGTAAAAAAATAAAACAACATAAATTTCATTTAAAACAAAAACGATTTTACCGCTCTCCGCTTTAAAGGCGCACACCCGTTTGTGGATAGTGGTTTAAACAAAAATATCGCGTCGAGACCAGATTTCTGCAGATTTCGCGCCAAGACCCTACCTTATCCCCCTGATACTGTAATTTGTGGCCTCCTGTCCCTCCTATGCACCACCACCACCGCCCCCATCAAAGCGGCGAGCTTCTTCTTCTCCTGTCTCGCCAAACTTCTCAAGTACTGAGGAGTGAATGGTGCCAGCGCGGCGATCGTTTGTATCGGTTTGCAGAATTTGTGCCACGATGTTGCTCGTAGATTTGCAGCGATAAATTGTGCAATTTCTTCTTTTTCGCAATTTCTGCCCTGCCGAATGAGACGATGAGGACTGTGCAGCGGCCACCGTTTTGAAATCCGGATTTTTGCTGGAAAGATAAAATTTAAATAATGAGGAGATTTTTTTCTCGCAGCGATTTCTCTGGACCCTGTTTATTCCCAATACGGTTTGATCTACAAAAAATGCGGGAATAAGAAAATGTTTGCCCGTTAAAATGCTGACGTCAGCAAAGTTTCTGTCTTAACGCTGCGAAATCAGTTGAGACTGCGTCTTTCTCCCGCATTTTTTGTAGATCTACGTAGATCAAGCAATGAGAACCACACTATGAGTGCAAACACTATCCACAATACATCATATTTGACGCGCAATCTTTAATTTATTTTTTGCGAGACCAAATAAATCTCAAACTTTCCACTGAAAAGGATTTTCATGATTCATTTTAAAAAAGTTGCGCCTCAAATGTGATGTGCCTGAATTTTCGCTTTTTTGAAATTTTTACTCCTATTTCGTTAAAAATGAAGGAATTTCTCGAACATTTATAGAATTTTAAAAATTTTCATTTTGGGTTAAAAAAATCGAGTTAAAAAACAACCATAAATTCAGGAAACTCAAAATTTTCTCCGAAAAACTTTCCCCATTTTACGCGTGAAATCTGGTGTATTTTACATCCGTGCCTAGGCTGTGTGAGAACACTGCCCGTCATACATTATATTTGACGCGCAAACTGCAAAAATCGTCGGAATTATTTCGGGAACAGAAAATTCTGAAAATGCGTAACGCGCAACTTATTTGAAGCGAAAATATCTCGTAGCGAAAACTACAGTAAACTTATGTAACTGACTACTGTAGCGCTTGTGTGTCGATTTAAGGGCTCAGTTTTCAAAAAAACGAGATCCCGTAAGTCGAAAGTGCTATGCAGTAGTTGCTATTTCAAGAATTACTCTAATTTTCGCGACGAGACATTTTGCGCGTCAAATATGTTGTGCAATGCGCATTTTCAGAATTTTGTGTTCCCGGAATAATTCCGACGATTTTTTGCAGTTGCGCGTCAAATATGATGTATGACCTGCAGTGTTTGCCCACATCGCCTAAGCACGGTAAAATCCGCCAGATTTTTCGCGCAAAATGGGATTTACGGCGAAAAATTCGAGATTTGCTGAGATGAGTAGGTCTTTTTTATTATTTCTTAATCCAAAAAAAAGTATTATGAAGATTTTTAAAGTTTCTATAGATTTTCTGAAATTCTCCGTCGTTGTTAATAGAAAAATTTCAAAAAATTGAAACTTCCGCCAACATTTGACGCGCAACTTTTTTGAAATGAAAAAGCCCGAATTTTCTGGGAAATTTGAGATTTATTTAGGTCTCACAGTGAAAAAAACATTAGAGTTTGCGCGTCAAATATCATGTATGACCGGCAGTTGCCCACATCGCCTAAGCCCGGTAAAATCCAGCAGATTTTTCGAGACTCGCAAAATGGTTTCGGCGAAAAATTCGACTGAGAATTTTGGTTTCGTTTTTACTATCTTTTAATCCAAAAAAAAATGAAAATTTTTAAATGTTCTATAAATTTCTGAAATTCACCCGTTTTTCAAATAAAAATTGGCGCATAAAAAACTTACACGATAAAATCCAAAACATCAGATTTTACGAACTGTTAGCAAAAAAATTGATTTTTTGGTTTTTTCGGGCTAAACATTAGAAAACCTCCAAGACTATACTCCAACAAAATTTTTTTTCAGTTTTTTTTTTGAAATTCTTTTTTTTTCAGTTTAAAATGTTTTCATCGCTTTGTTCGTGTTTTTGTTGATGATCTTGTGCGAAATTAATGATTTCCATATTCAACACTGTTGTGTGATTAATTTAGTACGGATAGATACACCGTAACTATTCAGCATGTTGAGTTTAGTTTTCGTCGTCCAATTTATCAAGGTTTTTTTTGATTTTCAGTCAAGTCTTTCGCGCTTACTTTTCTAAGCAGTAATGACCATCGCATGATTGCTAAGGGGTGCTTTTAGTGTTTGGTTTACTTCTGCTATTTCATGAGTCACTCCTTATCACTAATATAAATGCAGCATAATTCCCGAGTGAGCAAGCCGCGAGTATTAAATCACAGAAGCGCTGTTTTAAACTGATGATGATTGCAGTCTCCTTCATTGTTCTGACCGAAGGCTACCATTTTTTATTCATTCCCAGAGTCTCCTGACAAGTGGAAAGACAACTAAAAGCTATGTCCGTCTCGGACAAACCCGCTGCCCAATCAGGTGCCAAAAGCTTGGTACCGCTCCGCGCGCTGAAGAAGAGAAATGAGGAGTGGGGAACCAAGGTCAATATCGATACCAACATTCGCAAATTGAGTAAGTTTTTATTTTAAAATTACCAGTCGTTCGAGCTTATATATCAATTTTAGCGATCAAACCGACTCAGCGAATTTGTATACAAGTACGCTGTGCAAGTGACGTGTTCCGGAAACCTGATGGAACTGAGGCGACAATCTAAATCTCCAAATCAGGCAAAAAGGGAACGGAGCACGAGAACGACAAAACACGCTGCCAGAACGTTTACAATGAGGCGATCAAGCGTTACGATGAGCTGAAAACGACCGTCTTTCTACGATCGTCAAGCCTCTTTGTACACTTCTGACCAAATTGAAGAAAGGTGAATTCGATTTATTGCTTAAAGTTTAATATTTTAGCGTTTCAGAGCATCTCTTTCGTTGTGTACCGACAAGATTTGGTTCCAAGCGACAAAACTTCAAAGAGGCCAGTTTGTTCTCAAAAAGGTGGATACTATCAATCGTTGCAGTCAACATCGAATGACGTCATCAAGACAATCGTGCCCAGCCAAGACTGCCGACAAAACTTTGCTTGAGGCAATCAACATCATTGTCTCGGGTATGACCCCAGCGTTCCAAAAGAATGCCGCTTTCAGAGAAATCAAACGGCTATTACATCTCGCGGCAAAAATGTGAGCATATCACCGTTGGAGCATGCGTTCATTACCTCATCGACCCAACTGTAGTCGAGTAAACTGTAAGAAATAATCATATTAGTATTTAATTGTTTTTTCGCGTCGCGTACAAGGAATACACTGAAGGACATCTCTACTCAAGAGTCGGTGTTTCAAAGTCGGTGAAGACACAATTTGGCAGGAACGGCAAGAAAGTTCCATCACTCTTCAAGTGAAAGTTAGTTTTTCAGAAAATCTAGATTTTTTTCAAAATGTTATAAAATTGATTTTGAATGAAGACAACATTGTTCCCCGGTTTATGCCCCACTTGTGGAACTTTTGCAAACGTTCAGAAGTTTCACCACCTCTCAAAGCGAATGCTCCAGCCCTGGCGCAGAGAATTAAGCCTCTCTGTTGGACTGGTGTTGTCTTGAACTTTACGATGTGCACAAGGCGTCTCGGAGAGGATGGTGTCGTTATGAAGATCCGTCGATTCCACACGTCAGCTAAGGAGACATGTTTTGAAGTTGAGAAGTCAACTATTCACGAACGTCTTTGACTTCTTCAAAAAGAAGTATTGAATCACTTTGAAGTATCCCGATTTATACACCATTGAAGCGAAAGGGAAACAAGGCAAAATTCATTTCCCTGCGGAAGTTCTCCTTTTCTGTCCGAACCAGACAGGTCACGAATGATCAAACCCAGTGATCAACAATGAGCAGGCGGAGATGATTAAGGTAATTTGATATTTTAAAATCTGAATAATATCCCGAAATTTCCTTTTTCAGAACACCCACATATCAGAAAGACGACAACTGATACTATCGTGAGAAACGTCAGATTGGCTTCCAACAATATCTATGGCTTCTTCAAAGTTGAAGACCCTGTCAACCTTGAAGGAATGGTTCTTCCAAAACCTAGCGTTTGCCGGTAACCGACTCGCTGATTTGGAAAATCCGAAGTCTAGACCCCACCGACTTCAATCGTGCTGGATAATATTACGATGCCAAGGAATTGACGAATTGGGAACTGGTCTTTGTTCAAAACGACGAAAGAAGTCCAGTAAGTTTCAGCTTGTAATTTTTCATTATATTGACTCAATTTCAGTTAGGACTTGCTACGCAGCCTATCGCCGATGAAAAGGTGACTAAAGGTATGAAATAGCAACCCAACGATGAGTTTCATCATTAGAGGTGATTTGGAACGAATCGTCAAGAAAGCGAAGGCTGCTACGCAACTTCTCTTGTTCGTTGACAAATCTTGTACCATTTCAACTATCATAAAACTGCAAATCAAGGCGTTGGAGCGTATGACCTGCTCACTCAGCAGATTCGCGGTGAAACCGCCAAGAAAGTCTGCCGTAAACCAGACACAAACTCGTCTTAACATTATCAATAAGACAAAGCATGAAACTCGGAGGACTGAACTATGCTAACTACTTGTGAGTGAGGCGTTCAACAAGCCAAATAGAATATTGTCGTTGGATTTGTTACTTCTCAACGGGTTGGTGGAAATCCAGATGTGAGTCATGACAGCTGCACAATCATATTTCATTTTCTCCAGTATCCAATATCAGTTGGATTTGCTGCAAACATGCTCCGGCAAGCATCATCAAAAGTTTGCCCTGGTGGATACGGGTATGTTCATCGCGATAGGGATGTTTTCGCGATCCATCAGGCATAGTCCAAGGATCTTGACTATCTTCGTGCAAAACATGCACTGAGCAGCGCGGAAGACCAGATGGTATCCTTTTGTATTTCAATGGAGTTTCCGAAGGGCAATCACAATGATCAACGAGGAATTCAGTGCCCGAGTGAAGGAGGCGTGCATGGCATTCCAAAAGAGAGGGAACCGCCATTCAGACCACACACCATCATCGCCTAATCAAAGGCTCACAACGAGCGTCTGTGACAACAAATCCGAAAAGGGACGTATTGTTAATTTGGAGCCATGGGGGTACTGTCGTGGACCATACCATTGTGTAGCAATATCTACATTGAGTGGTATCATGCCTCAGCTGTAGCGCGCCAACAGCAGAGGTTACCAAGTTCACTCTCATCTTCACCACTAAAGCCGGCCCACAAGCTGAGCCATTGTGGCATCTCGGTACAAGCAATTGACCAATGATCTTTGCATCATCAGATTGTCTTCCATCCGGTCGGACTTCCCGTCCCACTGTACATTGCTGATCGTTACAGTCAACGTGGAGCAATGGTTCTTGCCGCCAATCAAGGGTAAGTTAAAATATATACGACATCTATTTATTATTTTCAGTCCACTACAATGAAGGACAAATCGATCTCGCGGCTACCAACAGTGCATATGGCTACGGAGAGAAGAAGCTCTTCACCCCCTACTCGTTTCAATGGAAAATTATCTGTACTTTCCTCTGTTTCTTTTACTCTTAGTGGCTGTATAATGTTTTATTTCGTCAACCCAGACTACTTTCGCTATGATTGTATATTTTTCAGCATTTGGTCATTGTCATTTGTAATTATTGTCGGAATGAGATAAAATGATTTATGAAGAATCAAATGCATCGCTTCTTGGTCAATTCCTGTTGATAAGAATCTCATTCAGATATTTTCAAAAGTTGTGGTTTATTGATATTAAAAAATATCCACGTTGCACGCTGCTGGGTCGCTGTGACTGGAGAAGTTGATGTTTTATGAATTCTTCCGTAAATTCAGCTGTTTGTACCTGTTTTGTAATGTTATCACTTTCTTTCGAACAAAATGTCGATTTTTCTGGCAGAAAATTCCACTTTTTAAAATTATTTACAACATTACAGATGGATACCTTCTGTTGTGTCTCGATTGGAGAATGTTACGAATCGAATGGAGAATGTATTGCTGAAATACGACTCGAACAAAGGAATTAAATAATTGTTCTCGAAATTATAAATTTCAAAATAATCGCTCTTTAGAAACTCCGGTCGGCGCGACGCCTCAAATCATTAATCTTAATGATGATGTGATCTGTAAGAATCTCGTCTCGTTTTATATTTATCTGCCAAAATAGGAGGAGATTTGAATCGCCTTGGATGCATGATAAGGACATATATAATATTTAATTCAAATTTTATCGAAAATTATTCAGTCTAAGAATCTATTTTTCAAACGCTTTTTTCGATGTTGTTTGTGGATTGCAGTGTGGGCGCAAAAACGCGAACACTACGACGAGTTCGCGACTCTTGTGAACGATTTGACGGCGGAAATTGTTGCATTTTCCGATTTCAAGGAGAACCGAAAATCCGAATTCTACTATAATTATATTTGTGGACTTGAAGCTGCTAGGTGGGACTGGTGGAAATTTGCCAATCCTGAGTCCGAATATCTATGTGAAAAACTCTTCATTATTTTATATATTTCAGCTCGAAATCGCATGTTCATACTTTTTTCAAGCACACGCCATATTCTCGTCGCGCCGTGTTGTGTCAATTTACGAATTTACCAATTGTTTTCCAATTTAGTTTTTAAACGAGATTTTTGTGGGCTTTATTTTTGTGAGTTTTGTTTGGGTCAAAAAAAATCTTACAAAGAATCATAATATCCTTTCAGGAAACTCAAATTCGCCGAACAACTACCCTATTTTGCGCGTGAAATATGGTGTATTTTACCTAGACTATCTGTGAGAATAATGCCGGTCATTCATCATAACTTTGATGCGCAAACTGCAAAAAACGTCGGAATTATTTCGGGAACACTTCTGAGCGGCGCAACATATTTGACGCGAAAAATACCTCGTAGTGAGAACTACAGTAATTGTTGCGTGTAAATGACTACTGTCGAGAATCGCTGTGTCGATTTAAGGGCTCATCGAAAAATAGAGATCCGGTTAAACGACACAACTGCTATAGTATTTGAAGAATACTTAGTTTTCGCTACGAGATATTTCGAGCGTCAAATCTGTTGTCAATGCGCATTAGAATTTTGTGTAAAAAGTTTTGTGTTTAGTGATTTTTGGAGTTTGCATAGCGCGTCAAATATATGACCGGCAGTGTATGCCCATCGCCTAAGCACGCTCGGTAAAATACACCTTTTCGCGCAAAATGGGATTTTCGGCGAAAAATTCGAATTTCCTGAGAATTTTGGTCGGTTTTACTATTTGTTTACAATGCAAAAAATGAAAATTTTTAAATTTTCTGAATTATCGGCACCGTCGTTTTTCACTATATAAAAAAATTTCAAAAAATTGAAAATTCCGCCACATCACACTTTGACGCTCAACTTTTTTTACATGAACAAGATCCGGATTTGTCTGCGGGGAAATTTGAGATTTATTGTGTAGGTCTCGCAGCGAAAAAAAAATTAGAGGTTCCGGCGTCAAATATGATGTATGACCGGCATGCACATAGCCTAGACACGATAAAATACATCAGATTTTACGCGCAAACTGGCAAAAAAATATTTTTTGGCTTTTTCTAAACATTTGAAAAAATGGATAGATATTCCAACAATTTTTTTCAGTTGTGTTTTTTTTGTGAAAAATTCCTTCTGAAGTTCAAATAAATATATACTTTTTTAAAGTTCGAAAAATTCACATTAGCGCGTTAAAAACGACGTAGTCAGGCATCACATACATTTGACGCGGAATCTTTTTATACAAGAAGGATTTGCGCGTCAATCTGGCGAATTAGGTTGTCGGCGGAATACACCGGGCAAATTTCACGCGTAAAACTTCAAACCCTGTTTCAATAATAATCGGAAAGAGTATTCGAGGAAATTACGTCTTTCAACGTCTCCGCTGGAACCACGACAGCAAGTTTTGTGTTGACGGAAAAAAAACAACATTAAATTTTTCGACACAAAAAATTAAATTTTTCAACGAAAAATAATAATTCTAAATTTTACAACGCAAAAAAAAATTAAATTTTTCAAATAAAAATTAAATTCGATTGATTCAACAAAAAAAAATTAAATTTTTCACCAACAAAAAATGTAATTTTTCAACAAAAATAAATTTTTTAATGAAAAAAAATTAAATTTTTCAACGAAAAAAATTAAATTTTTCAACAAAAAAAAATTATTTAAATTTTTCAACAAAAAAAAAAGAAATTAAATTTTTCAACAAAAAAAATTTAAATTTTCAAAAAAAAAAATTACTGGAATTTTCCAACAAAAAAAAATTCAAATTTTTCAACAAAAATTAAATTTTTCAACAATAAAAAATTAATTTTTCAACAAAAAAAATTAAATTTTTCAACAAAAAAAAATTCAAATTTTCAACGAAAAAAAAATAAATTTTTCATCAAAAAAAAATTCAAATTCCCGCGGAAAGTGCAAAAAATTTACAGAATATTTTCAAACCCCTCGCTTTTTCACTTGTCTCCCGCTATCATCTTCACGCAATTCAGCCGACACCTTTTCGTCGCCATTCGATGCGGGTTCCCAGCGATGTATCGATTTTCAGTTGATTAGATCGAGTTTTCGCTCCACGTACAGTACACTGAGTTCTGCTTCGAGGCCATCTGAAATTTTTTATTTAATTTTTTTAACGATTTTTTTTTCAGAAAATCAATAAATCTATTCAGCTTTTTTATAACTTTTACACAATTTTCCGTTTGAAAATGTCAAAAAAACCTCGTGTGTTTATGGCCACATTTTATTCAAAAAATTTTGAAAAAAGATTCCCTGCATTTTCCCTGTGGGACTCAAGAGAAGTGCGTGTGCCTTTAAGATTTCTATTGTTTTAAAAACTTAAAACAAAGATTTAAAAAATTCTGCTTTCTAAAAATACATAATTAGTTATTTTTTTGTGTATTTGTTTGGAAAAAATCAAATTTATCGATTTCTGTGAATTTTTTTGTGAAAAAAATCAGTATTTAGCGATTATTGTGCAATTTTTTCGGAAAAATCAATTATTATCGATTTGTATGAAAAAAATCAATACTTATCGATTCTTTGTGATTTTTTCGGAAAAAAATCAATAATAATCGAATTTTGTTAATTTTTTAATCAAAATTCGGCTTTTTCCGGTAAAAACATCTAAATTTCGCAAAATTAATCTGATTATATATTCTGCGAAAAATTTAAATTTCTCATACTTCGAAAAATCGAATATTGTAAAAATCAATAATTTCGATTTTTGGTTAATTTTTAAAAAATCAAGAGGTAATTAACGACTTTTTGATTTTTTTTTTGAAAAAAATCAATAATTATGGCGTCGTTTTTTTTTAATTGATTGGAAAAAATCAATAATTATCGAATCTCAAAAAACTTTTTGTAAAAATCAATAATAATCGTTTTTGTGTGATTTTTTTCGGAAAAAATTAAACATTATCGTTTTTTGAATTCTTTGAAAAAATTGATAATTATTGATTTTGAATTTTTTTTTGGAAAAAATGCAATAATCATCGATTTTTTTGTGAATTTGAAAAAAATCAATAATTATTGCCACGATTTTTCCGATTTTTTCCAAGAAACAAAATAAAACAATAAATTTTCCTTACGCCACGTGTCAATTACACCCCACGTGGCAAATCGTGTAGAGCGCGCATTTCGAATAGGGTGCCGCCGAAGAAGATTTCGCGTTCGATTTTTCGAGTTTCCTTGTCTTTCTGAAATTTTTTTTTTCTAAATTTTCTGAAAAATGTTCTGCTGTAAAACCTCTTTTTCCTCTCTTCTCCGCGCCATTTCGCATTGCTCTTTTTTTTATCCTTTTCCAGCGTTTTTATCTCTTTTTCAACTTCCCGCTCGTTGCGCATTTTGCGCGGTCCTGAAGAAGGTTTAAATTTTTAACAGGGGAAATTTGCTAGGAGAGTAAATATATTCGCTGTGAGACCCGTGGACATGAAAATTTTTATTTTCCGCTTAAAATAAAGACAACTGAATTTCGCTTATATTGTGATGTTGTAAGCTGAAAAAGCTGAATTTTGATAAATTGAAAAAAATTATCTTTAAAGGCGCATTTATTGATTTTTCCAAAAACAATTTACAAAAAAATTGATCATTCTTGATTTTTTCCAAAAAATTAACATAAATCGATAATTTTTTTTCCAAAAAATTCAGAAAAAGATTATGATTTTCAAAGTAAATACTGAACAATCGATAATTAATGATTTTTCAAAAAAAAAAAATCACAAAAGTCGATCATTACCGATTTTTTCCAACAAAATTTTCAAAAAAAACCACAATTATTGATTTTTTCCGAAAAAATTACAAAAAAATCGACAAGTACTGATTTTTTCTGAAAAAATTACTAAAAATTGATAATTATTGATATTTTACAAATAGTTAATTATTGATTTTTACAAAAAATTCACAAAAAAATCGATAATATTTTTTTCAAAAATAAAATTACAAAAAATCTCGGGGATCATTATTGATTTTTACCAAAAAAAATCACAAAAATCGATAAATCTATTATTGATTTTTTCCAAAAAAATTACGACGAAAATCGATAATTATTGATTTTCCCAGAAAAAATTCACTGAAAAATCAATTATTATTGATTTTTTCCGAAAATAAAAAAATTGATAATTTTTCAATTTAAAAAAAAATCACAAAAAATCGATAATTATTGATATCTAACAAGAAAATTACAGAAAATGGATAAGTATTTTTTTACGAAAAATTCAACAAAAAATCGATTTTTGATTTTTTTTCAAAAGAAAAATCACAAAAATCGATAATTATTGATTTTTTCAAAAAAAAATCACAAAAATCGATAATTATTGATTTTTAGGCGGAAAAGCCGAATTCAATTTTTCAAAAAAACAATCGATAGTTTTAAAGGCGCATGCGCCTGGATCTCACAGCGAAAAGTGTATCTTGCAAATTTTTTGGATAATTTCGCTGAAAAACGTATTTTTTAGACAGTTATCTCTTACAGGGAAAATTGTCTAAATCAAAAAAAAATTGTTTGTTAAGCAACATTTTTTCAGTTTTCATAAATTTCAGTTTTTTTTTCGCGAGAAAAAAAGCCAGCGAATTCTCGATTGAAAAATCAGAAAAAATATTTTGGTATCAAAATATTTTTGGTATTACGATATTTTGGGTCCCACCTCGAAAAGAGGATTTTTCAAATTTTTAAGATTTTCTTTGCAACTTTTAACAATTTTTTTTTCGGATATAAAAATCGATTTTCGCTGCGAGACCCAAATAAAATAGATTTTCTCGATTTGCGATGAACTTTTGAGTTTTGGTGAAATTAGATTCCAAAAAAATCGCAATAATAAATGTATCAAAAAATCAATACTTTCTGCGTCTCCTTCTCATCGTCAGTTAGTTTCCGCTTTTCGGGTCTCCCACGCCACGACATTTATGTCAGTATTCTCTTGTGAGCTGGAGCACAACGAGAATGAGCTAGTCGTCTGATTCTGACGGATCATTTCGTCAAGATTAGCCTTCCCTCCATATCCTGCCGTGGTTTTGCCGCAGCTGGAATTGCATCCTTATTCACTGCGTCGACGATGGAAAAGCTCGCTGGAGTACCTGGAATTTATCGATTTTTTATTGATTTTTTATCGGTTTTTCTCGATTTTTTTGATAACTGGGGGAAAACTCGGAAAAATCGATATAAATTTCGATAGGAAAATTCAAAAAACTTCGGGTCTCACAACGAAAATTGATTTTTTGGATTTTCAAATTTTTAAACTTTTGTTGTAACAACAGTGGAAATTTTTCGAAAAAAATTCAGTAATCGATTTTTTGGAAAAAAGGCAATAATTTTCGATTTGTTGAAAAAAAAAATCAATAATTATCGATTTTTTGTGATTGAAAAAAATCAATAATCTTCGTTTTGTGATTTTTTTTCGAAAAAATCAAACAATTATCGATTTTGGATTTTTTGAAAAAAATCAAGAATTATTTTTTTGTGAATTTTATGTAAAAAATCAATAGTTTGCTTCGTTTTTTTTTGGAAAAATCAGTAATTATCGATTTTTTGTGGATTTTGTGAAAAAAATCAATAATTATCGATTTTTTTTTGTATTTTTTGAAATGACAAAAATCAATAATTCTCGAGTTTTTGTGATTTTTTTTCGGAAAAATCAAAAATTATCGATTTCTTGTGTATTTTTTTTTGGAAAAATAAATAATTATACGAATTTTGTGATTTTTTGTAAAATATCAATAATTATTATCGATTTTTTGTGATTTTTTTCGGAAAAATCTTATCAATTTTTGTGATTTTCTTTGAAAAATCTATAAATATCGATTGTGGTGATTTTTTTTGGAGAAATCTATAATTATCGATTTTAGTGAACGAATTTTTTGTAAAATATCAATAGCCAATTATCGATTTTTTTGTAATTTTTTCGGAGGTAATCAATAATTTTCGATTTTTAATGATTTTTTTGGCCTTGGATTTTAAAAATTTTAAACTTTTAGAATAAATTTTTCCATAGTTTTTTGTTGAAAAAATCGTTTTCTGAAATTTTGAGATTCAATTAATTTTTTCTTTAAAAAAATCGTTGAAAAATTAATTTTTTGGAAAAAGAATCAGACGAAGATAGATTTCGCTGTGAGACCCAATTGGGCTCCGCAACTAGTGCCTGCGCCTTTAAATAGTGGTCGTGATTTTTTTTTTTGTTAAATTTTCCCGCGAAATTAAATCAGATTATTTCTGCGAAAAAGTGAAATTTCTCAAAGAAACTTTTGAAAAATCAATTTTTAAGACAACCCCTAATTTCTCCGATTTTCCTGCTAAATAAAAGCATCTAAAAAATTGGAAAATCCACAGAATTATCGCTGTGGGGCACAAAGTTCGGCATGCGCCTATAAGATTATCGATTTTTTTCAAATTTTTCAATCGAAATCAGGTTTTATTTTTCAGTAAAAATCATAATTTTACGAAATTAATCGGATTTTTTGTGCAAAAAATTCAAATCTTTTTTTACGTTTTTTCGCCAAAAAAACCATCTAAAAAATTCGAAATTAAAAGTCCCGAGCAGGTTATCTTCGCTGTGAGACCCAAGTCCGTGCTTTAAAAATATCGATTTTTTGTTAAATTTTGCAATCGATATTTGGCTTTTTTTCCGGTAATGAAAAAATCATAATTTTGCGAAATTAGTCTGATTTTGTGCGAAAATGCGCAATTTCTCATAAAACTTTTGAAAAATTGATTTTTTTTTTCTGGAAAAACCTATTTTTGTCGTTTTTTCGCTAAAAAACATCTAAAAATTCGAAAAATCTCCCAAGATAGTTTCGCTGTGAGACCCAAGGCTCCTGAAAGTCCCTGGGCCTTTAAAACTATCTTTTTAAATTTTTAATCGAAATTCGGCTTTTTCCGGTAAAAACATCACAAGTTCGCAAAATTAATCTAAGATTTTTTCTTCGAAAAATTCAGATTTATCATAAACCTTCGAAAAATAATCGATTATTCCGCTAAAAAATCATCTAAAAATCGAAAAATCCAGACAACGTTCGCTGCGAGACCCAACATGCGCCTTTAAAAATTTCGATTTCCTGTGAAAATTCTCACAATTTCTCCAAATTTCCCGCCGTCACATTCGTCGTTTCCAAATCATAATCCTTCATCATTGAACCATCCGAGAGGACTACAATCGTCCATCTGAAGTGGGAAAAGATCGATTTTTTGTAGAAAATCATATATTTAAATTGATTTTTTTTACAATAAAAAAAATTTTGGTACAGGATTTTTTTGGACAGTTCTGGTAAATCGTGAATCGTGTAATTTGGGCTAAATTCATTTTTTTCAAAAGGTCAGGGGGGGGGGGGCACTGAAGAAAAAATTTACAAAGCGTGGAGCGAAAAGGAGTAGATATACAGTCGCGAAGGAACGATCGCTCCGCCAAATTTGCACGCGGCAAAGGGGCGTGGTTTATTGGGGGCGGGATTCCGGCGCAACCCTGCGGCACGCTTTTTTCTCTCTTTTTTCGCTCGTTGGGTAATTTTCAGTTATTTTTATTCGTTTTCTGTTCGAAATTTCATTTCGCTCGATTTTGTTTTTTCGGATATAAAAAAGTGTCCAACCATTTTTTAAATGAAAAATAAACAAGTTTTCCTAACAGATTTTACCCGAAAAATGCTTTGTTGGTCTCTCTTTGTGAAATTACGTTTGTTAAGAGAGAAAATGGGGGAAAAAAAGTAAAATGTGAATTCAGAGGAAGCGTTTTTTTAACGTTTTGCTTCGTATATGGCATACAGAAGAGACAAACGAAGCCTTTTTTCTAGAAACTGATAAAACTTGGTTATTTTTTAAAAATAGACACTTTGTTATCCAAAAACGATTCACAAAGCGAAATCGTCAAATTTCGAACAGGAAAGAATAAAAACTGAAAATTGCCGCATGAAAAAAGCTAGAAAAAAGCGTGCGCAGGGTTGCGCCGGAATCCCGCCCGCAATAAACCACGCGCCTCCACGTTGCCGCATGCAAAATTGGCGGAGCGATCGTTCTGTCGCGACAGTATGTCACATGTAAGGTAACAAGGTTTGGTTTTCAGTTGAGAAAAGGGGGATTTTTTCTCCCGATTTTTCGCAGAGTCCACGCTCTCCTCATAGCCGAATACTAGAGCGCGCTTGCAGCGACTCTCGTTTCTGCAGCCGCGGTATTTTGATTTGCCACTAGAAAGCAGATATTTCATTTATCGAATTTTTAGGTTTAAAATTTTTTTTTTCTGTATTTTTCGAACACCTTTTGTCAAACAGTAAAAATCGAAATTAAAATAACTAAAATGAACTTTTATTGTCCACTGATTCTTGGTGAAATGGTTTGAATTTGAAGAAATTCTACCAACGGGCTCTCTCGTATTGTCTGGATATTGTTCTATTGAGATAAAATTTGGTTGTAATACATTGTTGAATTAAGGGTGAAAAAATGGTTTAAAACGATTTTTAATAGAAAAAAATTCAGAAAATACGAAAAATCTGATCATTCTAAATTCGAACCATTTCGCAACCAGTGGACGAAAAAAGTTGATTTATTTTAATTTCGATTTATACTGTTTAACAAAAGGTTTGTTCGAAAAAAACAGAAAAAAAAATTTAACAGCCAAAAATTCGCTAAAGCTAAAAAAGCTGCTCATTACATTGGAAAGGCAAAATACCGCGACGGATGCAGCAACAACGAGCGAGAAGCTGCAAGCGCGCTATTTCTATTAATTATTCAGGCTTTAAGGAGAGCGTGGTGCAGAGCCCCAATTTTAAACAAAAAATTGCGGGGTGAAAAAGTTAATATTTAAAAAAACGAGGATTAAATAAAAATTAAATAAGGTCAGCAATGTTCATTGGCATCTCATTTGTGTCGAGAAGTACTGCTCAATGTCGAATTCGTACGTCGTCCGTTTGTTTGACGAAATTGATGGCGACGCCCTTGCGGCCGAAACGTGCCCGACAGGCCGATACGCAGTATGGATGTAGAGCTCGCGGACTGTTGTTCGGCAAATCGTAGTATCTCCTGGCAAAGTTTTAAAAGCTGATTTTTGCGATTTTCGCCATTTTTTGACAAAAATTGGCGAAATTCGGAATTTTTAAACAGATTTTGACGTAAAGTAGAAAAGGTTCCAATGCCAAATTGTACGGTTAATAGCCTGAAATACTTTAAATTTCCTTTTTTGCACAATTTTAACAATGAAACCCTGTACTTTTCGCTACTTTTAGAAAAAAGCTTCCAAAACGATTAAAATTGCGGCAAATTTTATCTGAAGATTTTCGCAAAGTTTTCACCTACAAATTGAAGAAATCGGTATTTTTAAACAAATTTTGGCATAAATAGGTTAAAATACCAAAATTTTACGGTTTTTAGCAATTTTTGAGTGAATTTTCAAAATGTTCCAGTATTTTTGCAACTATTTGGTTCTTTTCATCTATGTTCTTTGAAAATTCTTTTTTTAAGGTGAATTATGTTAGAAAGGGGTCGATTTTGCAGAATTTTGACAGATTTCGCATGAAAATTTGAATTTTAGGCAGGCGAAAATCATCAAAAATATAAGATTTTTTGCGACTTTTAGTTGAAAAAATTGTACAAAACGAGTAAAATTGACAAATTTTTAACGATTTTCGCCAGTTTTTCACCTAAAATTTAATTTTTTTTGTCTAGTGAAAGTTAAATTCAGTGTTAAAATGTATCTATTTTCGCTCAACCTGAAATTTGAAAATTTTCAATTTTTCACTAAAATCCACTTTGAGAAACCAGTGAAAAAATTTTTTCAATTTGATGAAAAAATTTGCAGTGAATTTTATTTTCTCTGCTAATTTTTCGTTGAAAAATGCACTTTTTCAAGTAAGAATTAGCGGGATTTTTGGATTTTCATCTTAGGTCAATTTTCAATAATGTTGCTCGCTGAAATTGATTTTTTCTCAATTCATATTTTGTATGAAAAATTCCACCTTTTTGCAGAATTTTGACTAAGAAATTGCCACTCGCCAAAAAGTCTGAATTTTCTATTTTTCTGTGCTGACAATCATCAAATACGATTTTCAACAGAAATGAAATTTTCGTTATCTTTCGCGGAAAATCATTGATTACCTGATTTTTTCGCTACTTTTAATTGAAAATAGTTTACAAAACGAGTGAAATTGGCAAATTTTATCGATTATCGCAAGTTTATAACCTAAAATTTAGCTTTTTTCTAGTAAAGTAGGGAAATACAGTGAGATTTTTTAATTTTTCACTGAAATACATGAGAAATTAGTGAAAAAAACATATATTTGGCCAACTTTTCATATTTGATATGAAAAATGCCGTTCTGAACAAAAAAAGTGTCTGGAACCATTCAACTTATTATCAATTTTCAGCTGAAAAATTCATTTTTTTTTCTCAAGAATTCGCATTAAAACTGCGGAATTTCTTGTATTTTCAGAAAATGATGATGACACGCTATTCTTCGCGGAAAATCATTGAAAACCTGATTTTTTCGCTACTCATAGTTTAAATCAGCATGGTATTACATATGAAATTGGCAAATTTTATCAATAGATTTAAGTTTTTAACCTAAAATTTGGTTTTTTTTTCAAAGCGAATAGGGAAATCTTCAGTGTCAAAATTTACTGATTGGGTAAATGGAAATTGTGAATTTCCATTGTAAAAATTTCTGCTGGATTCATTTTTCCCTAATTTTTCATATAATTAGGCTAAAAAATGCAATTTTTCACAGGTTCGCATTAAAACACCGTTTTTTGTAGTTCTTATCAACGAAAAATGCTATTTTTTGCGGAAAATCACTGCAACTTTTTCTGCAGTCTCTCGCGGGCCAAGGAAAAGTGGTTTCTAGGCCTTGGCCGAGGGGCCGACAAGTTTCAGCGGCCATTCATCTTGCTTTGTTGTTTTCGCCTGTTTTCTTTGTTTTTCACAGCTTTCTCCCGTTTTTTCTCATTAAAACTGATAAATAAATGCACTATTTTTTGCAGATGCTAAAACAAGTTCCAAGTAAAAAAAATTATGTATGTCAGTCGGCAAGCAGCGGTGAAAATGGGCAATGTAAAATGATGGATTACGGGAGATACAAAACCTGAAATTTTTCTTAAACATGATACATATGCTGCTTAGATGCTGATACTGATTTTCATAACGAGACCGCTGAAAGTTTTGAGGTTTCCACAATTCAACTTTTTTGGTGATTATAAATCGAGATTTTCGCACAAAAGGTTGAATTGGTCTGAAAACCTCAAATCTTTTTCAGCGGTCTTGATATGAAAACCAGGTAATTTCAGCCTGGAAGCATCATATGTATCATGTTTCAGAAATTAGGTTGTGTATTCCGGTAATCCACCAATCATATTGCATTGACCACTTTCACCGCTGCTTGCCGCCTGAATACATAATTTTTTTACTTGGATTGTTTTAGCATCAAAAAATAGTTAATCAGTTTTACAGTAAGAAAAAACGGCAAAAAGCTGTGAAAAACCAAAGACTAAACACGGAAAACAACGCAAAAATGGCCACTGAAACTTGTCCCATCGGCCATCTCATGGCAACCACTAGCTTTCTCCCTTGTGAGGATAAAAATTTGCAGTAGGAAAATGCTATTTTTCGCGGAACATCGAAAATGCCTACCAAGGACACTTGCGGAACATCAAGTCATCTCGCTCAAACATCAGTAGAAATGAGCAGCTGACACGAGTGGTTCCTGCTCTAAACTCCTTCATAACCTCATCACGATCCTTCTGCTCCATATCTCCATGCTTCGATGAGACTTGGTAAAGTCTGCTGGGCTCCGTCATCTTATCAGTCAACCAGTCCACCTTTCTACGTGTATTACATAACAACACGGACCGCCTGAGTGATGGTTAAGGTGTCGTAGAGATCGATAAGCGTGTCGAACTTCCACTCCGATCAACTGCTACGAAGACAACTGCTTGATGCCTTCCAGTGTCAACTCGTCACGCTTCACAAGGATCCGAATCGGATCCGTCATGAATTCTCATCATCTCCAGAATCTCATGAGGAAGCGTCGCGGAAAGCAGCACCACCAGGGCTCCAGGCGGTAGATAGCGATAGTTATCGGAAATGCTCCTTGAACCCCTTGTTCATCGTCGGCTTCATCGAGCACGAGATGCTTGATGGCGCGGGTGCGCAGGTTTCGACGGCGAATCATATCGAAGACGCGTCCCGGAGTAGCCCACGTGCTGGTCGTTCCAATCGAGCTTTCGGATGTCCTCGCCAAGACATTGGTGCCTCCGAAACAGGCCTGGCACTGGACATTCGTCGCCGAGCGCCAGCACTTTTTGGAGTTTCGAGAACTGCCAGCTCCGTGTCGGCGAAACAGAGCTTGGGTCTCGCGGACGGGTGTCTAGCGATTGGAGAACGGAGATCGAGAATGTCGCTTTTTCCTGTTCCGGATTGAGCTTGAGCGATGACGTCACGAGCCTTGAGAATTGCGGGGATTGCGCGTTCTGGATGGCAGATGGATTTTCGAAGCCGTACGCGTAGATTCCACGAAGCAAGTCTTCTGCTGGAAATCGAAAAAAATTTTGAAGTTAGTTCTATATTTAAAGCCTGTGGTGTAGTCGAATTATTTATTTCTTTATTAGACTCAAAATTGCCTGAAAAAAAAGTGTACAAAACGAGTAAAATTGGCGACTTTTATCAATTTTCGCCATTTTCTAAAAAAATCGACGAAATTCGGATTTTCAAACAAATTTTGACGTATAGTAGGTTAAAATTCGATTCCAAAAACGGTTTTTAACAATTTGGTCGTTCTTAAAGTGTAGTCGAGCAATTATTTTTTTCTTTATTAGACCCAAAATTGTCTGAACACACCGAATTTCAGAATGTAACTTCTTGAAAACTCAAAACTTTTCAAAAAAAAGTTAAGATTAGCCTCTTGAAAAAAGCCCTAAAATTTAGTGAAAATTTGAAATTTGACCAACTTGTCTCCTGTCAAGCGGCTGGAAACAGTTTTCTTTGAAATTGTCGTATAATTTTGGGTATACAGCTCGATTACCTTGCGTCTTCAGCTTAATTTAGGTATTTAAAAGTCGATGGACGAAGAGATTTGTCAAATTTTTTTCACCAACTATCTTCGTCCATCGACTTTTAATACCTTAATAAAGCTCGGAAAACGCAAGGATACGTATACCCAAAATTAGACGACAAATTCAAAACAAATTGTACATTTCCAGCCGCTTGTCAGACAATTTGGTCAAATTTCAAATTTTCACTAATTATAGGCTATTAGCCGCCATAACTTTTATTTGAAAATTTTTCAAGAAGTTACTCATTATGAAATTGAGCGGTGTTTTCAGACAATTTTGAGTCTAAAAACGCAATAAAAAAAATTCAACTACCAACGGTGGAGCGAAAATTTATTAAAAACCGTATAAATTCTGGAATCCTACTTTACGAAAATTTGTTTAAAATTCCGAATTTCAATATTTTAGATGAAAAAATGGCCAAAATCGATAAAATTTGCCAATTTTATTCGTTTTGTACACTTTTTTCAACTAAACTCAAGTAGCGAAAAATCATGTTACCATTTGATGATTTTCAGCTGAAAATTCCAATTTCAGGCAAAATTCTTGTCGGTACAAAAAGGGTAATTTTTCAGAGAAAATATGGAAAGAACTGATAAAAAAAACTGTTTTCAGCAAGAAAAATGTTTGAACAAATTTACCTGTTAAATCTGCTTAAAAACCGTAAAATTTTGGAACGTTTATAACCTACTTTACATCAAAATTTGTTTAAAATTCCGAATTCCGTCGATTTTTAGATGGAAAAATGGCGGAAATCGATAAAAGTCGATCGCCAATTTTACTCGCGTGGTTTTGTACACTTTTTTCAAAGTAGCAAAAAAATAATGTTTTGACGCGAAAATTTGTTTTCAGCGACAAAATTCGCTGCAGAAAAAGTTCATTAATATGAAGCTTTCTGCTTAGTTATAGAGAAATTTGTTAAAATCGATAATTCAATACCTCAAGCACCACTTTGTCAAAAGTTGGGATAATTGAGACCTCGTCAGACGACCTTCGAACTCCACAGCTCGCCAAATCGTCGTTTTTCTTCTTATTTTCCGCCATTTTTGAAGGAAGAAGTCTGTAAAATCGATAAAAGGAATATTTTCGAGCATTTTCCGTGCAGAGTAATTCAGCATTTTTTGGAAATTATCAAAATCAATGTATTACAAAAAAATCAAGAAAAACGAGGAAAAACGATAAAATTGATTCGGGCATTTTGCAGATCAAGATTTTTAGAAGGAAATTAACATAATAATTTACATCGAAAAAATTAAGAACCTGTAAAATCCATAAAAAACTAGTAAAAGCAAGATTTCGAATGTTTTCGAAAATACCCTGTTTGTCGAGCATTTTTGCAGAGAATTTCAGCATTTTCAGGTGGAAATTTACACAATAAACGAAGTTACATCGAAAAAATCAACAAAAATGGTGATTTATCGGCTATTTTCGCTCATAATTCGTAGGATTCGATTCGAAACTAAAAACTTTCGAAATTCGAAAAAAATAGCCCTGGCCTAGCGTTCCCCTCCTAGTCCACGGCCGCGCCGATTTACGGAGAGTACGATTATTGATCGATGACGCATGGTTTCCGACTGTTTTTACTATTAAATTACCCTTAAATCACAATTTTCCATAGAAAACGGGTGGAATTCTCTCGAAAAATGAGAAATCACCAAAATCGGCGCCGGTTTCCGATCAGGATAATGCGATTTTGGTTTGTTTCATGAGGTTTTTTTAACATCGAAATGATTATTTTTTTGGTAATTCCAGGCGCTCAAAACACAACGGGACAAAATGAAGAAAATGATCAAGCGAAAAGAGAATTGTTTGGAGAAGGAACCACAATTGGCAAAGCAGCTAAGGATGGCCGGAAAGAGTAAGAAATTTCAGATAATTCAGTTTTTTATATTAAAAAAAAAAAATAGATTAAAATTTCGCTTTAGCTAATTCCAGCCGTGCTTTACTCCCGCTTCAAGCAACGCCACCAAGAGAAGATTACATGAGCCGATCAAACCTTGAACCCTGCACCTTAGCAAGCTATAATCGAGCTAATGGTATTGAAAAATCAGAAAAAATTGAAGTGTAAATTTTCCAGCAAACAAATCAATAAATTTCCTGGTAAATGAACCTATTCGCAGAAGTGCAACAGCAAGTAACCGATGGCCTTCGAGAAATGAAGCGCTGAAAAAGATTAATCAGAACTTCGAGATCAAATCGACAGGATTATGGAAGAAAAAGAGGCGGCGGAATATCAGGAAGAGATCGAAAATGCTGTCCGGCCAGCTTTCCAACACGGATCTCGGGTAACGTTGAGAATGGAGGATCTGTTGGCGGGCGGAATGGGGCACAGTTTCAACTTCCAGAGGCTCCGAGCCATGAGCCGCCTGAAGCAGAGCGGGAATGGCAAAAAGGTTGTAGATTTGCCCGACGAAAATTCCTAAATTTTCCCTAAATAAATAATTTTGTTTTCAGATAAAGAGAACGTCGCGAGAAGATTGCTCTGGAAGCCTAAATATTGCTTGTTACTGTGAATAAAATAAATTCATTATATTGTTATATTTTCTATACAATCTGGTCTTACTGGCGTTGTTCTGCACGTAAAATTCGTTTAAATAACGCTGTAACAAAAAATCTCAGTTTGCGCGTAAAATTGAAAATGCCAGTGACGCAATCACCACGACGAAAAATCCCACAGTTTTGGAAAATTGCGGTTTTTCAAACTTTTTTTCGCGTTTTTTCGGATGCTATTCAAGCGGCTATAGACTGTTCAAATAAGAACGGTCAGAAAATGAGAGACGTAGACAAATAAAGAGATATTGACTTTTTAGGCTATTCTGTGATAGTAACAAACCAACAAAGTTTGTGTTCCCAGTCTTTTCTTTGCAAATTCTCAAGAGTTCTTCTTTGCAGATGCGTCGACGTGAAGCTCTGGACAATTACGAGCATGATGGTAAGTTAAAAAATTGGAAAAAAAAACTTCGGTTTAAATTTTATTATACTTATTCCCTTTTTTTAATTAAAGGCGTCTATGACGGCTCATTCATCATTCACGACGTAGTTGACGCATTCCTCCTTGCCCGAAGGGCCTAGTGGGTTAACGCGCCATCACTCAGAAGACCACAAGTTCAAACCCAACGAGGCTCCCCCGCTTTTCTACCCCTAGCTTGAGCAATCAAATCCGAACGCGTCGGAGCTGTCTCGGAGACAGAAGCCTCATCAAATATATTGATTGCTTCCAAACCTATCGCACGTTTGCGCTCCTCATTTCCGTAATGGCGTTGCATGCGTAAGCTTGATCTTTCCAGTTTTCTACTAAGGTGAGTCATTAGAGCAATGGAGTGAGCAACTCGTTCCGATAATTCGTATCTCATGAGCAAATGCTATGCGGGACGCGGGGCTTTATGGAAAGAAATTAAACAAATATTATTCGTTTTCCACATGTGTGGCTCAATTTACTTCTTCTTTTTTTACCTCATTTTATAAAATTGTCAGCCCTTTTTCTCATTCATTTGATTTTCTGTGGCTCTTTCAGCTCTATGTAGTTCAGTTTTTCATCTATTTGTTTTAACGTGGAGCAAAATATGGTTGAAATTTGTCTGGTAGATACGGTAGCTTTAAAGGCGCATACTAAATTTAACAGTGACAAAATTAAATATTTAGTTCCATATGGAATTTCAATTTGCCAGGCTGTCCCATTACGGTTTGATCTACAAAAAATGCGGGTTTTTTTTAGGCCAATAATGTGACGTCAGTCCGTTCTTAAATGCGAAATCAGATGTGAACTCTGGGTCTCAACTCCCGCATTTTTTGTATACGTAGATCAGACCCAAAATGGAACTCTGACACCAGGTGTTCGCCGCGGAACCAGTTTTATACCGAATTTCGTATGCGCCTTTCATTCTACCGTACCCGGTTCTGGAAGTTTGGGTAAGTTTGAAAAACGAACTTTAAAATAGAGTTTATTAATTTTTGTTGACATATTACTTTGTGCAATACCTCAAAAAATATTATAATCCAGATAAACATGGTTTTTTAAAACGTTTTGCACAAAAAGCGATGATTTCGCTTCGAAGCCACTTTTATAAAACGCCTTGTGCGCCTTTAATTCCACCGTACTCGCCAAAATTGAATGAGCGAGTGAACTATTTTAGCGAAAAAATCGTTCTGATCGGTCCTGCTCTTCCTCTATCGGCTCTGGCAACGTCTTCCTCTTTGAATCTGCTCCATTGACAATCGCCTACCGGACTGGTTCTGGAAAGCCGTCCACACGGACAAGTACATTTTTACAACTAAAATCGAGTCGCGACGCGACACGCAACGCGCCGTAAATCTACACCAGATATGACCGAGAAATGCGGCCTAGTTCGGCCAATTCTTCCATTTTAAATTATGAAGCCAGAAATTCGTGTATTTTTACAAACTGAATGTGAAAAAGAAGCTAAAATTTCAATGAAATAGAGATTTTTCCCGTAATCTCACAGTTTCGCAAAATACTATGGTCCCATTAAAAAACGCTGAAACCTAAATTAGCGCGTAAAATTCAATGTATAGCGAACATCTCTCACGTATTTCTGGCTTTTATAACTCCCCTCAGATATTGCGATAGAAGCGGTTGCCGAACTAGGCCATATCTGGGGTAGATTGACGGCCGCGTTGCGGTAGCGTCACGGCTCGATTTTAGTTGTGAAACTAAATGCATTTTCCTGTGGAGTACACGCGATGTCCGGCGGGCGCTTGTCAATGGAGCGCGAAAAATTCAATATGGAAGGCCAGCACCCCGTGTTAACATTAAAATTACAAGATTTGCCCCCCCAAACATCCCTGGAGAACCTAGAAAAACCTGGTGTGCTTGCCTGACAACAGCGTTCACCGATAAAAGGGTGACGGGGAGGGCTGCAACAGAGCTTTTTTCCTCGTATAGCAACTCTTTGAGAACTGACAGCACTTTTCATATAACTCATCACTAATCGCTGCTCGTGGCGGTTTTATTTTCTAGTTCCCCATTTAGGGCTAATGAGTCAATTTTGTCTGTTGCTCAGAACTCTCAATTACCGATGCTATTAGCAGAAGTACTTAGCGCCAGAACCAGAGCAAAATCATTTTTATTTAAAAAATGAGTGATGTTTTCTTCAGTCTCTGTTTTTCAGGTTTTTCTCGTTATTAGGCGGTAACTTTCCACATACACTTGGTGTCAGAGAGTCCCATGGTTTGATCTACAATAAAAGTGTGACGTCAGCCCGATCTTAACCTTGTGAGTTGAAAAAAACATCTGCGTCTCGTTTCCCGCATTTTTGTCCGAGATCACACCGTGATGGGACTCTCTAACACCACGTACACATCTACCGAAAATTTCGCTGAGAACAAATTTTTGCGCGTCAAACCTGATGTTTCCGCCGTATATCAATACATTGAATTTGACGCGCAAACTCAGTTTTCATGGAGAATTGTTGAAAAAATTGTTTAATTTCCGGAAAATTAACATTTTTCAGAGAAAATCAAAATTATTCTGTTTTTCCATAAATTTCTAAGAATTGTGGCAGATCTCAGTTTGTTCTACGACAAAATTCGAATTTCCACTGAAAAAAGTGAAAAAAGAAGACGCTGTGTAAGCCTAAAAGCCTAAGACTAGGTGTAAGCCTAAGCCTGAGCCTATCCCTCAGGAGAATAAGCTTGAGCCTAATCGTGAGCCTAAGTCTAAACCTAAGCCTAACAAGCCTAAGCCTGATCCCAAGCCCGCATGGTGCCAGGCTGACCCATAACGGTTTGATCTACAAAATATGCGTAAAGCGAAATTTTTTGCCCAAAAAGTTTGACGTCAGCGCTTTCTCATGCGATATCAGTTGAGAACTCACTGCGTCCCTTGTCCCGCATTTTATGTAGGTCTACGTAGATCAAGCCTAAATGGGACGACACCACGGGAAGATCCCGAAGTATTCAATTTCCAAAAAATCAATAAAAATGCAAATAACATAGATATTCCCGCCTAGTCCAATAAATTATTTTTTTTTTGAAACTTCAACCTTTTCATGTTAAACTCGTTTTGTGGGAATGCATAGTCCCAAAAGCCATATTTGACACGCAATTTTCTTTGATAGACTTTTTTTTGAATTGATATGTCATGAGCATCACTCAGGTGGTTCCCAAATGGCGTCTAGTACTTGAGCCCTAGCCACCACCGTCTCGAGCGGCCGAAACCCAAAAACAAATAAAAATGAACAGTTCTCTCTGTTTCAAAATCTATATGTTCCTGTTCTTTCTAGTATCTTCCCTCTTCAGCCCTCTACTGCTGCTCCAATTCTGTTCCATGTTATTTACCGTACCGAACGATTTAGACGAATAACAGGACCCCCTTTTCCCGTTCAGCCGATGAGCCAATGTGTTGTTGGCTAATTCTGGGTGTTTAGCTCATTTGGAGGAACACTAACTTCCCTCTCTAACTACACACTACATGGAAGAGTGTTTTCAGATTTCTAGGCCTCGCAACTTTCCTTGGTGGCCAAGAAAAACTAAAACTTCAAGGTCAAAACGTTCATTTTTGTTGAAAACTACGAAAATCGGTTTTTACTTGATTTTTTGTAAGCGGAAGATTTCCTAAATTTCTAGGCCATGTGCTTTTTCCTGCTTCTCTGAAAATTTTGTTCAAATTTTCTTTTTTCAAAATATTCCCCGAAAATCTTGTACAAAAAGAAATTTTTGAGCATTCAGATCATTTTTTTAGAATGGAAGAGTTATCCAGATTTCTAGGCCACTGTATGGCTTTTCGTGGTGGCCTAGAAAATTTTCTTGGAAATCAGGTTTTGACTTGAATTTTCGTAAGTGTAAGAGTTTTTTACATTTCTAGGTGATTTTTTCCTGATGGTAGGAAACTTGTTTTCGTTTAATTTTCCCCTATTTTGGATATTGAATACTTGTTTATTGGTGGAAGAGTTTTCAGAAATTCTAGGCCACGTGGTTATTTTTGTAAAAGAAGATGATATTTATAACATTAACATGTGGTGACTTTTATCAGATTTTTTGCCCAAATACCATTTTTACAAGGTAATTTTTTGTTATATGATCTTTGTGGATAGAGTTTTTAAAATTTCTGTTAGGCGAACCCTAGATGCACGTGGTGTCAGAGTGCACTTCGGTTTGATCGACGTGAATCTACAGCAAAAATGCGGGAGAGGAGACGCAGAGTTCTCACCTGATTTTACATGGTTAAAAACGTGATGACGTCACATTTTTTGGGGGCAAAAAATGCCGGCATTTTGTAGACATCAAACCGAAATGGGACAGCCTGACACTACGTGTTCGTGCAGATGGCCTATAAATGCTAAAATCTGTTTTTTAAATGTAACTTTCAAAGTAAAAGAAACAATTAGAAACAAGTTGGCTCTCGCCCACAACGAAAAGTCTGTTCTAGCTATGGGTCGCGAAAAGACTCGGCTACCAATTTTTTTCGGCTCCAGATCAATGACGCTGGCAGACAGGGACTTATCAGCTTGTTTCCGATTTACACACACATACACGTACACTTTCTCCGTATAACTTCTGATAGCTTGAAACGAGATTAATCATCATTCCAGCTATTCTGTTTTATTTATTAGGTTAATGCCACTACTACTAGTATTTTTTCATATTAAAAATACAATGAACTATTTAGACATAGATTCAAATGAGATGCCAGTGAGTTCGCACTGGTGTAAGTGTTTTGAATTAATAAATTTTTCAAAAATATCTCAGTAAATTTCTGAGAAATTTTGATTTGAATTCCCGCCAAGCATTTTTTTGAAAATTTTGAATTTCAGCCCATTTTGCCTTTTTTCCTTCAGAAAAGGTGAAAAAATTCAAAATTTGAATTCCCGCTACAAGATTTTTTTTGAAAAATTTTCGAACTCGCGCTAAAGTATTTTCTAATAGCCGAAGGATTAGTAATTGGAATCCCCGCCAAAACATAATTCAGAAAATTTAAATTTCCGCCGAAACTTTTTCTGATAAAATTTAAATTCCCGCCCATTTTGTCCAAAATTGCAAGAACATATTTTCAGTGAGAAAATTTGAAAATATTTTTTTCAGAAAGTTTGAATTCTGTAGCACCAAAACATTTTCTAAGAAAATTTGAATTCCCGGCAAAACTTTTTCTGATAATTTTTGGAAATTCCCCGCAAAAATTGAGGATAGTAAATGAAGATGATTTGAGCAAAGTTATGACGTGGCCGCGGAAAAAATTGATGGCCCAGTTTTCTCTTTTCGCGGCCACGTAGCCAGAACAGACTTTTGGAACCGTACAACCAACAAATATTTCTTCATGTCCCTTTCAAAAATACATAAAAGCCAGATTTTGACATTTCTAGGCCATCTAGACGTAGACGTGTAGGCCTCGAGGCCTAGAAATTTGAAAAACTCTTCCAGAAAATTTGTTCAGTACTTGAAAGCGCTCCAACAAATCTATGCTCAAATTGTAAAAACGTTTTATCAAAATATTTATTGAATAAATTCTTTTGTCGCACAAAGAGGTATCAGACCACCAGATTCGACCTTTGATCATTGTTTCAGTTGATAGGTATGGCAGGCGTGGTTGCGCCTCAAACCTGCCGGCCTCAAGCTGGGCAAGAGGCAGCCTAATGTCAGGGGCAATGCCCACATCCAAGCCCTACTTCTAAGATTATCTCGAAATTTAGCGAGTTTTTATTTGTCCAAAAAAAATCGGAACAGGTTAACAGACAAACATGAAAAAGCCGCCAAAACAGAACTTTCATAATAATCTGTCGGTAGTTTGTGGCCGTTTCTTGCGTCTCAGGCTTAATCCCTACTGTAATTATGCTGAGATTTTCTAAGGATCTATGATCCTTTCACTTTTTGAAAATTTTTGGCAATTCTTTTTAAGTTTGTTGAGATTAACTTATGACAAACAGTAACTAAAAAGCGTGTGCTGCCGCCAGATTTTCTAGGCCATCAGTAATATCAGTTGCGTCCTTGACCATACTGGACCGAGACAACAAATATTCTAGGACTTGAGATTGCGTTCCTCGTCCATTCCTAGTCCCAAAAATTCCAAGCTAGTTTGGCCGAGAAATAATCTAGGCCATCGATGTTAATGACGCCATTTCATACCCGAATTCGCCAGCCTAAAATTCTTAGGTCATCAGTGACGTCACAGCTCTTCCAAGCCTTGGAATGAGCATTTCTAGGCCCTCTAATCTAGGCTTGCAAATTTCCTAGGCCAGGTGACGCCATCCCTCTTCCGTGCTGGACCGGTCAAATGACGTCACTTCTCGTCCACCTACGTCGCACTTTGATTACCTAGGCCACCATGTAACGTCACTTCTCTTCCATCTAGGTTTCCCATGCCCTTCTCCTCTCACGTTTGGTATCAGTGTGTCATTTTGGCCTTGAATACTCTAACGACAAATGAAATGCGGGAGAAGAGACGCAGAATTCTCACTGATTTCGCTTTTCCGGGTTACGCGGTAGACGTGCTGCCGTCACATGTTTTTGGGCAAAATTCCCGCATATATTTTGTAGATCATACCTTAATGGGGTGTCCTCTTGTTAAATATCGAAATTTCACTCAAAAATTTTGAACGTTGACGTTTTGTCTCTGGTCAATTGGTCAGCCGCGCAGTGTTCCGGTGTTTGTGCTCATGTTTTCCATTTGTGCTGCTGCTAAGGCTTATTTGTTCCGGGCGGGGACAGGGGGGAGAAGAGGCGCAAAAATGTGTCATTATGTATATTTTGCCATTGATATTGTCCTTCTGCTCAGAGGATTTCCTCATTTTACGCCGTATGTGCAAAAGCATAATCACCACAATAATTTTGAATATAAGTTTGCAAACGCGCCCTATTGACCTCGCCCGTGTAGTCTGCGTGCACGTGGTGTCAAAGTGTCCCATATTGGTTTGATCTCGAGAAATGCGGGAGAAGAGCTGCAGACTTTTCAACAGTTTGATTTTGCATGGTTAAGAGTGTGCTGGCCGTCGGTCACGTTTTTCTGGGGGCAACAAGAAATTCCCGCATTTTTTGTAGATCAAATTGCAAAGCGGCCTATTGTTAATCTTAGCCCGTCTTTTGATTTTCTATTATTCTTCGGCACCTAAACTGTAACTACGACACTAAGTTACACTGTTAAATTCCGCCCACTTAATGGCACCTTTGTTGCAGAAATGTACCCACGACAACGAGCAGACACGACCACATAATTGAGACGAGAATTCGGCGGAACCGGCTGGCGCAGGTCGCCGCCACAATTGCTGCCTTAGCGTGATATGACTCTTGTTGGCAGGTAAGTAAAAAACTACGACACTCCGAGACCAAGAAGAAAATCGATAATCGAAATATTGAAAATTGCAAAATTTATTTCGCCGGATCATTTTCCATATCGATTTTCTGAATGGTATGGTGATAGCAATCCTAATCGTAGGGCGTCCCATCCCTGGTGAACCACGGACTCTTGACCTGAAAAATAGGTTTCGTTCGGTGGAGCACATTCGCATACACTGACATTTTCGGGTGGCGACACGCTTTACACTTGCAACATGCAGTACCATATGCCAGTGGACATTGAACGCCGACACGCATCTCTCAAAAGTTAGATCGGAAATTTCGTGGCATTTTGGTGATTGGCCGCCCGGTGACAGTCCGCGCAACGGAGCGCGTGACCGTACGGCCCGGGCATTGGATAACACGGAGTCATGCCAATGACTGTCTGGAATTTTGGAGAAATTTATTGATTTTTTGACGGAATTTAATGAAATAAGGAAAAATCAATAATCGACATATTTATTTCGTAAAAAAAAACATTCTTTTCACGGATTTCTTCTTCAAATTGCAATTGAAGAGTTTGCCAAACTAGGGAGCCATTTTGGTAACGCTCGGCCATATCTGGGGTAGATTTACGGTGCGTGTCGCGTCGCCGGTTTTGTAGTAACACTAGCAAAATGTATTTGTCCGTGGAATTCTGGCTACCCTCATAAATCGAAATGGCAGAGTTTGCAGAACTAGGCCATTTTGGGTCGGAGTGATTTTGTGTAACGGCGCGTCGCGTGTCGCGGCATCGCCGCTCGTTTTCAATTTTAAAACTATTTGTCCGTGTGGCGCACACAACACTTTTCCACGCGCTGTCCGGCAGGCAATTAGTGTTGGGCGCAAAAATAATTAGGAAGGCCAGAACCCCGTGTCCGTGTGGAGTGCACGACTTTCCCGCGCGTTGTCCGGCGGGCGATTGGCAATGGAGCGCGAAATAATCAATGAGGAGCTTTTTGCAAAAACAAATTACATAGGCTTCTTGGCCTTCCTTATTGCATCTTTCGCGCTCCATTGACAATCGCCTTAAAGCAGGGGAGTGTGTGTGTTTGTACCTTCTCCACACGGACAACTTAAAATGAAAACCGAGCCGCGACGAGACACGCAGCAACGCGCCGTCAATCGACTCCGGCCGTGGCCGAGTCAATATGCCTTACGGCAAATTCTTACATTTCAAAATATGAGGGAAGCCAGAAACGTGCGGCACATGTTATAAAATTAATGTTGAAAAAAAACTATTAACCCATATTTCGCAAAATAAATTATCGCTTTTTGTAAGAAGGATCTTTCGTGATTGAATAGGGAAAAATTTATCGAATTTTAGCGAATCAGAAAATATCCATTTTCACTAAGAATTTATCTAATTTTTCGATTTCTATTCGCTAAAATTATCGATTATTGCAATACCTGACAAACCGAGCATTTCAGTCATGAAATAAGATACATCTCGTCTTGAAGTTTGATCACTTTTCCCTGCAAAGAAATTTCAATTGAATGTATTTCGAAAAATGTGCTCACAGTTTGAGCTGCTTGACGAGTCAGCAGGTTGTTGTGCAGCCTTTCCAATGGATATTATATGGAAGAACAATCTTATGGACGTTTATTGTTCATCGGGTCGAGAAAAACATTTTTCGAATTTTCGAGATTAATTTACCTAAAATCTAAAAAGGAGAAAATTGAAGAGAAACGTGGGAAAACGTATTGATTTTTCAAAATTTTGTTGATTTTCTAATCACGGGGTTCTGGTCTTCCGAACTCATTAGTTGATCTTGTCGCGCTCCATTGACAATCGGATCTCTTTCCGGACAACACGTGGGAAAGTGGTGCACTCCAGAATACACGGTTAGATAAATACAAGTTTTACAATTAAAATCGAGCCGCGACGCGACACGCAACGCGCCGTTACCCCAGAGGCCGAGCCATAATGGCCTAATCAGTTCGGCAAACTCTACCATGGGAAGCCATAAATTCGTGTATAATCAGAGAACTTGCGCAATTTAACAAAATCGGTAGTAGTAATTTATCGATTTTCCTTCAATCGTCTCGATTTTTTAAAAGCCTTATCGATTTTTATCACTAATTTATTATTTGAATAATCAACGTTTATTGATTTTTGAATCTACATCATGATTTGTCGATTTTCTCAAGTACCTATCGATTTTTGCTGTCGATGCACCATGTGGAAACTTCGGCACGTTTTTTCGCGGCGAGACCCAAATTTTTTGAATTTTCAGTTCTTGGTCTGGTATACGGTAGCTTCTACCTCTACCGTCGATATGTGACAGATGCAAATAAACGGTATAATGATGATATTTGCGAAAACTCGTTCGTCAAGTCAATGACTCGCCGGAGACCACGTGGAAAGCGAAATTCGTTTGGTGTCAAATATCCTTACGGATTCAAATAAACTTGAGAGGCAATCAGACGGCGGTCGAGGAATACGTGGAACAAACTCGAAAATTCAATTTCGAGTCAACGTGATGCGATGAAGCGGTTAGAGTGTTAACTCAAATTTGAGCGGTAAACAACGATGCTCCGCACTCTCGCCGCAAGTTATGTAGTTTAACGCGTAAGCTGTGATGCATACGATAGTCCTGGAATGATATTTGTTAGCTCTCGCAAATGAAGGAATTACCAAATTTCGAGAAAAATCTATATTGATTAGCCTTTTAAAAATTATCGATTTTTTAAACAAAACTTCTGAATAATTCGACGGATTTTTCCAGAAGTTTAAAAAAGTTTTGGGTACAATTTTAAAAAGACAGCAAAGCTAATGTACGTAGAACACCAGGAAAGAATTCTGCGCTAATATCGGATGCTTCGTAAACTCCACGGGCTTGCGGCATTAAAATGCCGAGCTACGCGCCGTAAATCTACCCCGGCCGCAACGCGCCGTAAATCTACCCCGGCCGTGGGCGAGCTCAAGTGGCCTAGTTCGGCAAAGACCAATCTTATCGATTTCTCCTAACAGATGAGTGAAGCCAAAGGCACGAGAATGATGACTTCCACACGGTTCGGTAGAGCGCATTTACACTTATGTACCCTTTGCCGGGCTGCGTTCAAAACCTAAAAATTTGAATGCGCGTAAGACCTGGTGCATTGGGTCCTGAATTATTTCGACAAAACATGGTGCATAATCCCAATATTGCAATTTTGCAGTGAACTTGAGCACAACAGCTCCGATGTTCCGAAAAACTTCGACGCTCGTCAGAAATGGCCGAATTGCCCGTCAATTTCGAATGTTCCAAATGGAGGATGCGGGAGTTGCTTCGCGGTCGCCTCGGCCGCCGGTGTGTCGCCACCGACCTTGCCGGTACTCACTCGAATGGAACTTTTAAGTCACTTTTGTCCGAGGAGCATATTATTTGATGCTGCTCGGAGTGCGGAAATTGGTACGGCGGAGATCAACTGAAGGCCTTGACCTATTGGGTTAATCAGGGACTTGTTACAGGTAAGCGGTGACGTCATTGGCCTAGGAACCTTTGATCTGCATAGATGTGAAATTTTATTGTTATCACGCAATTTGTAATAATTTCTAAAAAACTGTAATTATCGATTTTTAAAATTAACTTGTTCCAAATTTTGAATCAAACGAATTTTCTAGACGCGAGATTTTTGCAATTTATCGATTTTCGCAGGCTATTGAGTTTTCCCACAGTAGTCGATTTTTCTAGAAAATTATCGATTTTTAAATTTTTTTACCGCATTGATTTTTCTAGAAAATTAACGATTTTTCTAGAAAATTTTCGATTCTAAAAAAAATAATCGACTTTTTTCTCAAAACTATCGATTTCTGCAATTTATCGATTTTTTGAAATTTATCGATTTTCCCTGCCAATTAGCGACTTTAAAATATTCCCCAAAAATTTGAACGAGTTTTCTAGATATTATCAACTTTTGCAATTTATAGATTTTTTTTTTGCAACTTATCGATTTTTTGCAAATTATCGATTTTTTACGGCTAATTCCTTATCGAGTTTTTCCAAACAATAACGATTCTTCTAAGCCCGTGGAAGCGTTTATCGAAAACCTAGGCCATCTCTATTTTCCAGGTGGCCGTGACGGTTGCCGTCCCTATTTGACCTGTCGTGTGGCTTCAGTCCAGTGGTCGCCGGCCACGGTCTTTGAGGCCGAGGTTCGAGAAGACGGACATTCGTATGAAGAGGTGTCTGAATACCTCTTACCAGCAGAAATATGAGGACCCGGATAAACATTTTGGCTAGAGATATTTTTTTTTAGAAACTAAATAGAGAAAAATTTCTGGGATCTATTCAAAAATGGCAAACTTTTTGGAAATTATCGATTGTTTCCGGTAAATAATCATCAATTTTTTTCTCGGAAAATCTAGATTTTCGGAGATTGACCGACATTTTTTTCGAAAATTGTCGATTTTTTCCGTTAATGATCGATTTATTCGGAAATTATTGATTTATAGTTCCGATAATTATCGATTTTTCGGATAATTATGGATTTTTTCCGATAATTATCTATTCTCCGGTAATTATCGATTTTTTCCGATAATTATCGATTTCCCTTTCCGGATAATTATCGATTCTTTTGGCCGATAGTTATCGATTTTCCCGATAATTAGCGATCCGGTATTTATCGATTTTTTCCGATAATTAACGATTTTTCCAATAATAATCGACTATTCTTCCGATAGTTATCGATTTTTCCGATAATTATCGATTTTTCCCTTTCGTAATTATCGACTTTTCGGGTAATTATCGATTTTCCCGATAATTATCGATTTTTCCGGTAAGTATCGATTTTTTTAATTATCGATTTTTCCGATAATAATCGACTTTTCCGATTGTTATCGATTTTTCCGATAATTGTCGATTTTTTTCGATAATTATCGACTTTTCGGGTAATTATATTTTTTTCCGGAAATCATGATTCCTATAATACATTTATCAATTTTTTCCGATAATATCAATTTTTCCGACAATTATCGATTTTGGTTATCGATTTTTCGCTTCCTATAATTATTGATTTTCCCGATAATTATCCATTTTTCAATTATCTTTTTTCCGATAATTATCGATTCCGATAATAATCGACTTTTCCGATAGTTATTTTTCCGATTTATCGAGTTTCTTTCGATAAATATGCGACTTTTCGGGTAATTCTAATCGATTTTCCCGATAATAATCGATTTTTCCCGTAATTATCGATTTTTTACGGTAATTATCTTCCGAGACTACTCGACTTTTCCTTACGATACTTATGGATTTCTCCCATAATTATCGATTTTTTTGGCCGATAATTATCGAATTATTGCGGGCAATTATCGCTTTTTCCCGACACGATAATTATCGATTTTTCCGATAATAATCGACTTTTCCGATAGTTATCGATTTTTCCGACAATTCGATTTTTTCTCCGGTAATTATCCACTATTCGGGTACATTTTCGCCCGATAATTATCGATTTTTCCCAATAGGTAATTATCGATCTTTGCCGATAATTATCGATTTTTCCGAATAACTTTTCCGATAGTTATCGATTTTTCCGTATCTAAGATTTTTTTCCGATAATTATCGACTTTTCGGGTAATTATCCATTTTTTTCCGGAAACGTCATGAATTTGATTTCCAAGTAATTATCAATTCCGAGAACCTAATTATCAATTTTTCCGATAACTATCGATTTTTCGGATAATTATCGATTTTTTCCGATAATTATCGATTCTCCCGATAATTATCGATTTTTCCGGTAATTTTCGATTGTTTCTGATAATTATGAATTTTCCGATAATAATCGACTTTTCCGATAGTTATCGATTTTTCCGACAATTAACGATTCGATTTTTTTTCGTAATAATCGACTTTTCGGGTAACTTATCGATTTTGCCCGAGCATAATTATCGATTTTTCCGGTAATATATCTATTTTTACCGATAATTATCGATTTTTCCGATAATACGACTTTTCCGATAGTTATCGGTATTTTTCCAATTATCGATTTTTCGATAATTATCGACTTGCATTCGGGTATAAATTCGATTTTTTTCCGGAAATAATGAATTTTTCCAATACTTATCAAGTTTTTCCGATAATTATCAATTTTTCCGATAATTATCGTTTTTCGCGATAATTTACGTCGATTTTCCGATAATTATCGATTTTTCGGACCATAATTCTCGATTTTCCGATAATTATCGATTTTTCATACGATAATTATCGATTTTTCCGATATTTTTTTTCGGAAATGGCTGCGCCATCGCGGTTTGATCTACAAAAAATGCGGAAAATTTTAGCCCAAAATGTGACCTCAGCACGTTCTTAACCATACGAAATCAGTTGAGAACTCTGCCGCATTTTTTGTAGTTCTACGTAGATCAAGCCGCAATGAGACACTCTGGGACCAAGGGTCTGTAATTGACTTCACGGGAAATGATATTTTTATTTAATGCGCAAAACTAAAATTAAAAATTTCGTTTCGACCAATACACCATTTTAAGCGTAAATTTCAATTCAAATTTTTGCAGCCAAAGCTTTGGCTATTCAATGTATCCCCGCTCAATGACAGTATCCCTTACCGATGGAAAGGAACGAGTAAAGGTGCCCGAGTAACTATCATCGGTCACTTCAACGAGAAAACCGAGAAGCTGAACGTGACCGAGTACGGTGACATCATGACAAAACAGAAACTTTATGGTCCAGACACCACGATGGCGTTCCGACTTCCCGAAGAATTCCTTCATTATTCGAGCGGAGTGTTCCGCCCGTAGCGAATCCACCTGATGGTTTCGACGATCGAAATATAAGTGTGTTGGCACGTGGTTGTTCGATTGATCGGGGAGAATCAGATGATGGAAAACATTATTGGTTGGCTGTTAATAGTTTTGGTAACCATTGGGGTATAATGGTGATGCGTTATGGCAAATTGCGCACGGCCCGGCAAATGGTACATCCATACAAATACGCTCTGATAATTCGGGGTAAGTTTAGCCAGGTTTGGTTTTAAGGAAAACGCGTTGGTCCAAAAAAGTTAGAATTTGATTTCGGACATTTTTTATATGCATCACAAAAATGGACAAGCTTGAGAAAAAGCCCAGGTATAACACCGGTATACAAATTGTGTACAGGTGCCACTTCCCGGGCCGGGATGCGCGTTAAATATAGTGCTTTTTAAGAATGCGTGTTGCGCAACATATTTGACGCGCAAAATCTCGTAGCGAAAGCTACAGTAATTTATCAAATTACTACTGCAGCGTTTATGTCGCTTGTTACGGGCTCGAAAAAAAAGTTACCAGGACATTCTATTTTTTCTGATTTTTTGCTTATTTTTATATAGGAATATTCTCACGGTGTGTCATTCTGATCCCATAACGGTTTGTAACAAAGAATGCGGGAATTTTTCGCCCAGAAAAATGTGACGTCAGCACGCCCCTATCGATACGAAAGTTGTTGAGAAATCTGCGTATAAAATCCCGCATTTTTAGTAGATCACGCCGGGGAGACACTATGTCACCACGTGTATTCTATCCAAAAATAAATTATTTCAAAAATAGAAGCCCGAAAAAAAAAATCGACAAAAGCGCTACAGTAGTCATCAGTTAAAGCGAATTACTGTAGTTTTCGATACGAGATATATTGATATTTTGCGCGTCAAATATGGTGCGCAGAACCATTCTTAGACTTTTGTGTTGCCGTAAATAAATTTGGACGTCAAATACAGTGGATATTGCGGGCGATCGGCTACAATGTATTGCGAAGTTTATCAAGAGTGCGTCAAAAATATGATGGAGCCGCATCGGTCATGTTACAAAACACCATATTTGACGCGCAAAACTTTAACTTTGGACAAAAAGTCAGAGAATTAGGATTGCGTAAAAAACTGGCATTTTTTTTCAGAACATTTCTGAAATCAGTTTTATATTCTCAAACCTTTCGCGTCAAATATGGTGCATCAAGTCCCGAACCAAATACACTCTAACACGTAGTGCCAGGCTGTTCCCTATTAGTTTGACCTACAAAAACGCGGGAATTTTTCGCCCAAAAAAATGTGACGTCAGCACGTTACCATTGCAAAATCAGTTGGAGAACTCTGCGTCTCCTCTTCTCCCGCATAAATTTTGTAGATCAACGTGATTCAGGCCGAAATGTGACACTCTGACACCACGGCCCTAATTAACTCGTAAAAATCACCGTTTTTTTTCCAGGACTCTTCAAAATCAACCCAGATGACATGGAAAAATATGGTCTAGAGTATGAAACAGCAGTCGTCTAATTAATTGTTAATTCGGCAAAAATTTTTTATAATTAGTTAAATATTGTCCACCTATGTCATTCCCGCCCGATTGCATCACACCTTGTCCCATTTCCGACAAAAATCAATTATATTTATATTCGGCCATTTTTTTAGCTCACTCATTCCATAGTTTTTTTTTAATTAAATTTTGGATGCTAAAATTTGCCATTCTCATAGACATTTTCAATATCTGTGTAAGATAAATCTTTTTTCTGGTCTTCAATTGATGGAAAAAAACAAAAAAACAATGCGCGTCAGGTTTGGTGTATTGTGTGCAAACACCGAGCGCATATTTTAAAGGAAATTTATTTTTTTTTCGATTAAAGTTGCTGATTTTCTTTAATTCTTAAAAATGTAGGATTTTGTGCCAGAAACCGAGAAAATTGAAGAAGTCCTTGTCAAAAAATCGATGAAATCCCTGAAATCCCGGCTCCTTCAAGCAATTATCATCGACCAAAGTAAAATGCTGACTTTATCAATTTTCAATTACTTTTGCATGCATTTTTTCTAGGTTTTTCTCGAAGAATTCTCAACAAAATGGTACGGAAAGTACGGCGAAGATGGGGAACTTCTGGAGCACATCGACGAGGACTGGGAGCCCGTAGGCCTCGACGGTGAAATTTCTGCGCCTACTGTGGTATGGGCAGGAGGATCAGGAGTAAAAAGCTCATAGGCTCTATGATTGGGATGAAGAAAAGAAGGAATGGGTGCTGAGGGAGGCCAAGCAGGAGGAGTCAATGAGGAATCACAGAGTATCAAGCGAATTTCGGAACGAGTATGATGATATTTATAAAAAAATGGACGAAGAATTGCAAGAAAAAGCGGCAAAAGCTCAAAAAGAAGATGAAGAGAAGAAAGGGCAGAAGAAGCGTAAGAAATAAGTAGGCTTGGGAGGCGGGTGGAAGGCGCTAAAGAGGTCTGGTTGACCTAGGAGATAAGGTTCATGCGGTTATGAGTGTGTGAAATCTTCCGGAAGCTATTACAGACCAGGAATTCCAGAAATTTATGCCAAGTGGAGTTATTCAGCCGGCTATTCGAACGAATAAGCCGAAATGCAATGGCTTTACCGGGAGGAAAACGGCAAACTCAAAGGCGGGGGACGGATGATGTTGTTATATTAAGAAGGAATCTGTCGAGCTTGCCTGTCACATTATCGATCGAGCGAGCTTAAAAACGGGAAAGTGAAGGTTGAGGAAGCTCGATTTGAGATGAAGAGTCTGATCCGGCGAGGAAGCGGCGGAAATTGACTGCGGCGCAGAAAAAATATGGAGCAGCAGAGTAATAAAAAATATTTGGTGCAAAATTTGAAATAGCTCCTAAATCGACATTAACTAGGTGAAAGAAAAGCCCAATGAAAAAAAACCAAAAAAAATCGTATTACGTGAACACAAAATCCTGAGAATGCGTACTGCACAACATTTTTTTTTTGTTTGACTCGCAAACGGGATATCTCGTAGCGAAAACTAAGACTACTGTAGCACTTCTGTCGTTTTACGGGCTGCTCGATCGAAATGATTTAAAAGAATTTATTTATGGGATATTTAAAGTGGGCAAATATTTACCCGTAATAGGAAAATAATACAAAAAAATCTAAAAAATTTATTTCAATAATCGAGCCCGCGTAAATCGACACAAGAGCGCTACAGTAGTCATTTAAAGAGTACTTTTCGCTACGAATATTTTGCTCGTGAAATAAGTTGTGCAATACGCATTCACCGGTCAGAATATTGATATGTTCCCATAATATTTCTACCCGCGGAAAAAATTGGCCCAAATCGTGGATTGTTTGAATTTGATGACAAATGGCTTTGAAAATCACAAAATTTCAGAGAAAAATTTCGATTTTTGTTTTAAAAAATCAAAAATTGACTAAGAACCCAACAAAATAGTTAACTTGAAAACATGTCTCCTGAAAATCTTAGAATTTTCAGAGTTCACCCGAAAAATACCAGATTTAACTGGATAATTGCGAATTTTAGTGAGCCAAATTCCTTTCATTTTTCAAATAGAATGTTAAAGTTAAACTAACGACACAAAATCAAATGAAATTGACTAAAAAACTATTGAATTTTGTATAAAAATCCAAAACGATTTTTGTAAATTTGCAACAAAAATATTTTATTTTAGCATTTATTTATTAGTTCTTATAATTTTCACACTAAAAATTACGAAAAAAGACAAAAAAATTTTTTTCATTCAACAATTTTTCGGGCTAAAAGGTGTAATTTTTGCAGAAATTGAAAAATTATTAAAAATCGTAGAGACTAACTGACAATCAATTTTTTAAGGACCAAAAAGCCAACTTTTGCCGTTTTACTCTTTTTCCGTGAAAAATCCGGTTTTTTTTATTTAATTGCGAAATCACTTCACACCTAAAAGGGTAATATGCTGGTCTCGACACGACAATTTTTTTGTTAAATTCTTAAAAAGGTGTGCGCCTTTAAAGAGTACTGTAATTTAAACTTTACGGAATTTTTTTTTGATTTTTCAAACAAACCACGAAAAATCGTAGAAAATTCCACAAAGTTTGAAATTACAGTACTATTTAAAGGCGCATACCTTCGAGACTTTCTTGTACAAAAAATATGTCGTGTCGTGACGATTACCCTAATTTTTGGCGTAAAAGTCGTAAACTGTCCGGATTTCACTACGAAATTCAAACTTCGAGGAAAATATACGAAAAAAATACACTTGTTGTTTTGGTTAAAATATATTCACTTTTTTTCTACCATTTTTTAATAATTTCACGAATTTTTCCCTCAAAAATTACAAATTTCAACCAAAAATTCTGATTTTTCCTTTCCAGAATCTTCGAATGGACGCCCGATAATCCACGTAACTACCGTCCAAAGTCGGACTGTACGGTTATTGTCAAAAATTGTTCACTCAGTAAATGATGAACAAGGATGCGGTGATGTTGGTTTGAAAGAGGAAAAATGACACATAGTTGTCAGAAATATGGGATTGTTAAGAAAGTCGTCGTTTATGCGGTTGGTATGAAATTTGTGGAAATTTCGATTTTTGGCAGGTAAAAGAAATCTAAAAATGCTAATTTAAAAAAAAAAGCTTTCAAAAAATGCTAATTTTCCAAAAATTGAAGCTAATTTTGGAAAAAACCCAAAATTTTTTTTTTTACAAATGTTTCGATATTGTCATAAAAAAATATAAAAACGTGATCAAAAATTTGAAGCTATTTGTCGGAAAAATTTTTAAAAATGTAAGGCTAATTAAAAAAACCCAAAAGAGGTTCTTGGATTTAACAAATTTTCAAAAAAATTGTCCTAAAAAAGATAACCTTTAACATTAAAAAAATTATGGCTATTTTTCGAAAAATATTAAAAAAACAATTAGTTTTTAGCTTTCCGAAAAAAAACCGAAAATTTGTGGAAATTGTCGATTTTCAAAAAAAACTTATTCTAAAAAAAAATAAATTTTTAACATTAAAAAATCTATCTTTCGAAAAAAACACCGAAAATTTTTGGAAAGTTCGATTTTCGAAAAAAAAGTATTTTAAAAAAACAATTATGAGAAATGGTTATAAATTGTTTCAAAAATTTTTTACAGCTATTTTTTTTTAGAGTAATTTAAAAAAAACAATTTAGCTAATTTTAAAAAAAGTAAAGATAATTTTCAAAACCCAATATTGAGGATTTATCGATTTTAATAAATTGTTCAAAAAAAGCTAAATTTAAAAAAATTATTGAAATTTTTAAAGAGGGTTATTGGATTTTTAATTTTCAAAAAAAAATCATCAAAATGTATAAATAAATAAAGACTATGGTGCTTATTTCGCGAAAAATTGGAAAAACAATTTTTAGCTAATTTACGGAATTAAAACAACAAATAATTTCGGAAAATCGAAAATTGTTGGTTTTTTTTTTCGAACGCTTTAAAAAAATCCAAAATCATCTGAAAGACATTTTTAAAATTTCCAAAAAGAAATTATGAGTATTTTTCAAAAATCAAATCGAATGATTATCTACCGCTTTGTTTGACATTTTTTGAAATTTGAAAATCATTAATTCATAAAATTTTTATTGAAATAATTCAAATATTTTTATTGAAAAAAAACGAAAATATTTTCGCTTTGGAATATTTCGGAAAAATCGATTAAAAAAACAAGTAAATAGGTCAGTTATTTTTCAAGAATGCTATTTTTTGGAGAAACCGCTGATTTTTTGTCAGTTTTGTCGATTTTCGTTGTAAAAAATTAAAAATTCAAAATTTCTTATTAGGAGTGCACAAAATGCTGAGAATGCGTATTGCACAACATTGACGCGCAAAATATCTCGTAGTAACCATACAGTAATTCTGACATTAAGTACTGTACTAAGCGTCTTCGGAAAAATTCCACTTTTTTCAAAAAAAAAAACGAAATATTTAGTTTTTATTAAAAAATCGAAAAATTTTGATTTTTTAAAGTTAAAAAAAACGAAATATTTTGATTTTTTATTTAAAAATGAAAAATATTTTCCAACAAAAAAGGCTCCTAATTAAAAAAAAAAAATTTGCGCTTTTGATACAAAAGTGCAGATTCTTGTCTTAAAATTTAAATCAAAAATTTTTAAATAGACTTTTAATCCATCAAATTTCCCCAATTTTCAGGACCACCCGGACGGCGTCGTATCGGTTACCTTTCGTGCAAAGAAGAATCGGATATGGCTGGAGGCTAAAATATCTTCACGGACAAGTAGTTGAAGGTCGGAAATTGACAGCCGAGCTCTGGGATGGCCGGACAAAGTTTAAGTCGAGGAGACGGAAGAGAATGAGGGCGTCGGAAGGAGTACGAGAAGTATATTGTGGGTGAAGTAGTGAGACGAAGGAGGAGAGGGACGACGATGATGACGGCGAAGATAATTGATTGATCTAAAATTTTTCTGAAAAATTATTTTTAGTTCATACATTTTTCCGAGAGGAGCAACCGGATTGATCAATTTTAAAACTATGTTCAAAATCGCCCAAAATTAAAATTAGTGAACTTCCGTTTTCATGGATTTTTCGAAAATTAGCTTTAAAAATGTTTGCCAAATTTTTCGACGATATCGCGATGTTTTAAAAAGTTCGAACAAAATTTGCCTAATTTCAATTAAAATCCCTTTTTTCGAAATTTTCTAATTTTCTGGGCCAATTGGGCCGTTTAAAAGAAGACTAAGAAAAATGGCCAAAATTTGAGAGTTCAGCGTTAAAAAAATTCTAAAATTTCAATCAGACTACGTTTCCGGTGGAAAAAAATTTTCTTGGAAAATTGCTTTCTTGTTTGAAAAATTATTTTAGTTTATACATTTTTTTTCCGAAAGTAGGAACAACCTATCAATTGAAATTTTCAAAAAAAAATAAATTTGAAAGCATGTTCCGAAAAATTACGTGTTTTCGGTTTTCTGGAAAAAAAAAACGAAAAATTTCACCAAAAATCAAATATGAACATACTTTCCTAAAAATATGAAAAAACCAGAAATTTTCTTAATTTCCCTATTCAAAAAAATTCAAAAAAAAAACCAAAATTCAGTTAAAATCCCTTTTTTCGGAAAATTTTAAAACTGCTTTTCTGCGCCATTGTGTCGTTGATTTCAAGGAATTTTTTTCTTAAAATCCGTGAATCGTTTTGAAATTAAACAAGAAAATTTGAAAAATCAAAAATTATTTTCACGAAAAAAAATCAAAAATTTCAATCTTACGGTTTATGAATCCTAACTAAAAAAAAAATTGAAGTAACGAAAATGTTCAATTTTTTCGAAAATTTTCGAGGTCATTTAGTTTTTTCTGTGAAAATTGTATTTTATACGAATACTCTTTTAAATTAATTTTTATATATTCCTTTCCCGAAAACTTCAATAAAAAAACCCAGTGATACAATTAAAATCGAGATAACCACAGTCAAAGTGGCAGTAAGCAGGCAAAAGCACATATTAAGGGAATACAAAATTACTGATAGCGTAAGTCTCATCGCGCTCAACAGATTTGACGCGCGAAATATCTCGTAGCGCAAACGATAATTCGTTAAATGGATACTGTAGCTAGTGCCGATTTACGGGAATCTTAAGAACCTAAAGTAGCAAAAATGGAGATCCCGTAAATCCACACTAACACGCTACAGTCTATATCCGTTTAAAGAATTATTGTAGTTTTCGCTACGAGATATTGTGCGCGTCAAATATGTTGTACAAGAACTACGCAATTTTAAATTTACGTCATAATATACACAATTAACTAGTAATGGATCTACAAAAATCTACAAAATTTCTTCATCAAACTCACTCTTCCACAGCTCGATCGTCCATGAGTCTCCTCGTACGCCCACCAGAGAGCACATCGCCACGGTGCATATTGTCGAGACTTCCTCATTCTGATATCTGTGACGACATGCGTGGCGTAACTCAGGTTATCCCTCGCAACGACTACCGACGGACGGCCTCATCTGCATGGGACGAAGACGGTCCACGTTTCGAGCGTTTCCATCCGGCTTCGATCAGTGCGGCCGCTTCGATGACTGAATGAATTTTTATTTCAACTTTTGCAGAAAAAATTATATTTAGCAAAATTAACGGGGAAAATTGGCTGTTTAAAAAATATTTATTATATTGCGCGTTTAATAACAAGTCCAGATGAAAATTCTGCAAAGTTTGAAACTTAGTACCCTTCAACGGTGCACACGTTTTAGAATTTAGCACAAAATTGGCGTGTTCACGATGCTTTTTGGTTAAAACATTCAAGAAAGTGTGCGCCTTTAAGGAGTACTGTAATTCAAACTGGCTGATTTTTCATCGATTTTTCACTTTTTTTCCAATTAGTAAATTTGTGTTATTGCAGATTTTTTAAATCATTCATACCAAATTTTCAATCGAAAAATACAAAAAGAAAAAATGTAATTTCGTTATTTTCAAAAAAATAAATTGAAAAATTGAAAAAAAATCCAAATATTCGAGTATATTTTTTGAAAATAAAAATGAAAATCGGAACAGATTGTTTTTCGATTTTCCAAAAAATTTAAGACATTTAAAAAATCTAAATTTTCGATTTTTTAGAAAAAAAATTAAAAATCGCAAAAAACCAAAAAAAAATTGGCTGATTTTCCATAAAAAAAAGGAAAGATAAACAAGAAACAAATATTTCAAAAAAAAAAACAATTTTTTCCGATTTTCGGCAGAAAAACAACTGTAAATCGGAACAATCATAATTTGTTTTTTCTATTTTTCACAAAATATTGAAAAATAAAAGAAAAAAGGAAATTTTCGATTTTTTTCCGTTCCAAAACAAAAAATTCATAATCTCACAATAACCAAAAAAAAATGAAAAATCAAATAAAAACGAAAATTTCGTTATTCTCAAAAAAATAAAAACTTTTTTTTCTTCCGGAAAATCTCAAAAACACTGGCAAAAATGTCGGGTGACGAACATTAATTTTTTTCTATTTTTTTGGCCACGATGTTTCGCGAAAAATTGTCAAAAATTAAAATTTTTATTTTTAAATCCAAATTTTCACTTCCCCCCCCCCCCCCCCCTCACTAACAACTTTCCGACATCTTCACAATCTCCATAGCTTTCTCTTTAACCTCCGGCCAAAGCGGTCACTCAGCTCGCGGAGCCACCTTATCCGAAAACACAATCGTTCCAAGCTTCACCACGGCGGTCTCACCTAGAACTCCATCGACAACGACATCCTCTCCAAAATGTTCGCCGATTTTTCGATTCAACGAGCTTCGCCGTTCATAGCACGTGTGTGCGAGCTTATCACCATCGATAACATCGAAATTATGCGTTTCACGGAGATATTTCCCGATATGACTTTGACGAAATTCCTCCGGCGAGCCCAATGATGTGCGAGGTGCCCGTTTCTCTAGGAACCACCCGAGCTGGACGGAGCATGTGACCCGGATCCTCTCTTCGTCTGGAGCTTGAGCTGATCTTTGTCTCTTTCAGGATCTCATCGGATCCTTCAGGCAGCTCGACAATTATCACATCCAGCTGCGACATTCCTTGCTCATTTCTCTTTTTGTTCGAGTACCGCATTGGCACCTTTAATAGTCTCCCGGGACACTACTAGCGCTTCGAGGTTTTTTATTTGAAGGACCGAATGGTTCGATTAAGATTGGCTCCGCGAAACATTTTGCCTGGAAAATTATGGGGGTACTATTGAGCAAAAATGACCTGCATTTTTGGAAAATTAGAAAATCGGAAAAAAAATTTTCGTGCCGAAATTTTTTATTTAGAAAAGTTTTTTCTAAAAACAGAAATTATATATTTTTTCAGTTTTACAAAAAATCGAAAAAAAATATTTCGATTTTTCGGATTTTCCAAAAGAAAAAAAAATATCGAAGTTTTTTTAGATTTGCAATAGCCAGCAAAAATTGATTAAAAAAAACCGGAAAATGTATTACGGGAGAAGATTCTGAGCATACGTTGAACAGCATATTTGACGCGCAAAATATCTCGTAGCGAACACTACAGTAATTCTTTAAATGACTACTGTATCAATCAAGCCCGTAAAGCGCTACAGTAGTTATTTAAAGAATAACTGTAGTTTTCGCTAAGAGATAGTTTGCGCGTCAAAGATGTTGTGCAATACGCATTCTCAGAAATTTTGTGTTGCCTTAATTTTCCGTTTTCAATTTTTTCTTTTTTTGAAAATCTGAAAATTTCGATTTTTTCCAATTCTTTTGGAAAATCCGAAAAATCGAAACAAAAATTTTTCTATTTTTTAAATTTTTTTTTTTGGAAAATCGGATAAAAACCAAAATTTTAGTTTTTTAAACAGAATATTTCATGGACCAAAAATATCGATTTTTCCTAAAGTTTTAGAGAAAACTGAACAATTTAAAACGATGTTTATTGTTTTTATTTAAATTTTTATGGAACAACTTTCGATTATTATTTTGAAAAAAAAGCTTTTTTAAATTTTTCTTTATTTTTGGAAAATCGAACATTTGCTATTTTGCGATTTATTAATTTTTTTGTTGGAATTTCTAAAAATCGATGTTTTATTTTTTCAAAAATCAGCGGTTTTTCCGAAAAATGGCAAAACTTTTTTTAAAAAACATTTAGTTCTTTTCCTATTTTGGTTATCGAAAGATAAATAATTTTTTTGGCAATTTTTAATGAATTTTTGATCGTAACCTCTTACAGTCCCGGAAATATCAGTCCTGTACAGAATCGACAACTGCTTCTTAACATCCGAAACTCCGCAGCAGCTCAATCATCTAATAATGATTGGAAAAAAACCAATTTTTTGTTTTACGAAGCTATCATCTAACCAAGAATCATATCCTGATTTCCATTAGGTGACCCCCACGACAATAAAATCAAAAGCGAGCTCGGCAGCCATGTTGAGCAACACTTGGTGCCCATTGTGAAGCGGCCGATCGCATGTGCCGCCAACACAGACTTTTTCGTACTTTTTCGCCGCCGTTTTTCCGCATTCTCCAGCAGCTTTTCCTCGCCGATCACATAATGATTCTCGGGATTTCCGCGGATTTCGGACACAACTAGCCGGACGTAGAGCTTCGGGCATGAGTTCGCCGATGTTGATTTTCGAGACTAGCTCGTCGGTTCGCGGCTCGTCCGGGTTTAATCTTGCAGCAACAGGAATCCTTGTTCACCTTGCATTTTCGAGCCGGGAAAAAGCCCAAAGCACTCTACCTCACATAAAGCTTCGAGCTTAACGCGGCGGCCGCAGAAGTGTGCAATTGATACAGTTTTCATTTTTGCTATTTAACACGAGAAGTCCGTATTTCGAGCTGATTTAGAATGATGAGAAATATAAGGGGATTGAATATTCCTCAAATAAATAGAAAAATTCGCTGCCACGTTCGCTGCTCTTATCGGCTGCGCGCCTCTATTTCACATACTGTCTCTTCTATCTCTCCTCTCGCGAATCTCGCTCTCTAACGCGTGCCGTGGAGCGCACTTCGCTCCTTTTTGCTGGAAATCTTTCAGACATGCCGGAAACAAGAAAAACAATAAATTATTGAACGGAAAATAAAGTAAACGTACTCATCGTATTTTTAGCTTCATAAAAAGATCTCTTAGAGCATATAATATTGCTTCTAAACACCAAATAGTAACATCGCTGAAAATGTTGTGAATTTTATGAAAATCTAGGATCATTTTTCCCATTGTTAGTTTATGAAAAACAACAATAAAATGAGAAAGATTACATGGGAAAACCGAAGAAACTCTCGCGGTCAAAATTCGAATAGAATTACTGTATTTTTCGGTCGGGCGCTCACGGAGATATTTTGCGCGGGTCAAATATGCTTGGCGCGGCGTGCATTCTTCTTTCAGCGTTTTTTATTTAGTAAAACAGTAATAAAATGATTAAATGCATTTTGTGTGATTTTCAGCCCAAGATGTTTAAATAAATTGTTGTTGTCCAACTGCCAGCCATTTTTAAAAACTTAAATATATGGGAAAACCATAAAAATGAAGACAAAAGTTTAGCATAATTTTGGAACTACAGTACTCTTTAAAGGCGCAAGCCCTTTAAGACGAATTTGTCGTGTCGAGACCGGACAAATATTCAAAATTTCTTCTATACATACGCAGATTTAATGTACAGCAGAATATGAGCATTTGCACATTGCGCAATTGCTAAATTTTTTCAAGGATCACAATAAAAATTAAAAGTAAACCAAAATACTTTATTCAATACCACAAATAAGTTCATTTATCTTAGTCAACCTCTTGCCGACGTCGTAGCTTTTGTTGTTGCTTCCCCTTCTTCTTAGACATCTGAAATTTTCTCATATATGGAACGCGCTCCGATCTAACAAAAAACCTTCTACTTTTGGATTTTCTTCTTGTCTACATCTTCCTTCTTTGGCTGCTGTCCAGATATTTTTGTCCCCCGGCTCCCGGATCGCTCTCAAAGTCCATCTCCGGCTGCAGCCCAACCTCAGGCGGCGCGATCATCAGTACCTGCTGTTATCCAGGACCCTTGAAATACGTCATACAATCCCAATCTGGTGGCTCCTGGGTATTTGACTTATCTCAAACAGCTTCTCGCTGGATCCCATCAGCGATACGATCGTACTCCACAACAACTCAGCGACATCCTTGGGCTCGATGATGGTCAGAAGATCAAGAACCCTGAAGTAGTCTCCGGAGTGGTTCTCCCAACCGACGCGACCATCTGGTGGGTGCAGTGATGCGACGTTTCACGAGGAGCACGTCCTGTTCGCTTTCCTTTTTGAGCAGTGCCACACATGGGAGAGCCGTGAAAGAACCCGAGCACCTTATGTACCACCAGGACTCTGACCCATGTCGTTCCTTGTAGCCGAGATTTTCTGGGAAGAAAAACGTTGTCTTAAAGAAATTGTGAACGGTAAGGTTACCCCCTGGTGAGCATGAACGCTCGCGTACTTGACCACTCCTCATGTAGTGAATCCACTCTTTCTTCCATCTGCTCCTCAGCTTCGTCGTTCATCTTGACGAAGCAGTTAATTTTAAAAAAAGTTTTCGGGGTAGATTTACGACGCGTTGCGGATCTGACGCGTCGCGGTTCGATTTTTTGAAAAACTAAATGTCACATATTTGTCCCTGTGGAGTACCGAGCGACTTTCCCACTCAAAATAGGATGGAATTGAATTCGGAAGTGTCACCGTAGCAACATTCGGATTGTCTGAATAAATATAAAGTGAGATTTTGATTTTTGCTCCACTGATAATGGAGTTTTTTTTAGAAATTCTGCAAACATTAATTTCTAGAAAATTTGAGTTACCTCCAAAATTTTTCACAGAAAATTTGAATTCCCGCCAAAATTTTATTCTCAGAAAATTTGAATCCAAAATTTTTTCTCTGAAAATTTGATTAATTCCCGCCAAAAGTTTTTTTTCAGAAAATTTTGAGCCACGGTCGCATTAAATTTTTCTGCACTAGGCTATTTTGTGGCAATACCAGGGGTTGTGGTTTACGGCGCGTTGCGTGTCGCGTCGAGGAGTTTAGTTGTAAAACTAAATGTATTTGTCCGTGTGGAGTACACGGAAGACTTTCTCTCCACGCGTAGTTCCTCAGCAATTGTCAATGGAGCGCAAAAACTGCCGACCCAAATAATTTTTGCACTTCATACACACAGCAGCTCGCGGCGTGGCATGAGGCCCGCATTTCGCGCCTCACTGGAAGCCCCAGATGCCAAAAAATCTACCTGTCAGCGGTCTCTCTCCACCGAAACCCAACAGGCTGATGGTGCGGTCCGTCAATCTCTCTTCCAATACCGAAAGGCGATGGCTTGATGTCGCGAATGAATCCATTCCGGTGGAAGTCACGAATCGCGGATGGCCAGGCTCGGCAAAGTGAAGACCTGCTGAACTTGTCCATGTTCATATTCATCATCAGCTCGTATATGGAGGGCCATACTTAAAAATTTGGCTTAGCCAACGAAAAGTGGTACCAATGGACCACAATGGAAGCGATTTCCGTGCCACCTTCCTCAATATTCGTGTAGAAGATGGGTGGTGGATCGACGCGAGGACAACTGACTTTTGACGAAGAAGCTGGAATTTTTTTTGCTCTCTAGAAACGGTTTTCACGGCGGCCGTCAATTCCCGAGTTTGGAAACTCACTTCGTCATGTTATTTTATAATGAGTGGCTAAACTCGGAAATTGTCGGCCGTAAACCACAAGCCAGTTGGTTCCTTCGCCGCGACCGACACTTTCCGGGTTCCGCGCCGCCCTATACAGAAGGCTGGCTGCGCGAGGCAGGCTTGACCGCGGCAGGTGTTTTGGCGTGACCGCTGCATGGACCTGCTAGCTTGTCAACTAGGCAGCCTAAGCGAGCCTGCAAAAGGTAGGCAGGCGCGACCCTTCTAAAACCGTCCTCGCAACACACAATACCTCACTCTTCATGTTTAACGCCATTTGACCGCAAAAAACTTCCCATCACTCTCGCGTTTTACCTTGTGAATCGAGCCGGACGTGCCCGTCGCCAGCGGTTTCGTGACTTCATAGGTGTTTTGTGCTCGAATGAGCTCCTTTTGCGTTGTCCAGGTCCGATAACTCATTGATTTAGAACACCGAAATGTCACGATTATACGCAGTGAATCGCGTAAATAATCGAAAATGAGACTCGAGTCGAAACTTTTCGAAACCTGCTAGATTTTCTTTGTAGGGTTGTTGGAGTTAATGATGATAATGAGGAGGGGGGATTTTATGTGGATTAAGAGGCTACCAGGAAAATATTTATTTTTTAAATATTTTATTGTCATTCTTTTCTTTTTTAGATTTTCACGTTTCTTATTATTAAAAATAGAAGAGTTTTTCAGTATTTCAAAACGAACACAATCTGAAATTCAGAATTACTACTAAAGAAACGAAAAAAAAACTGAGAAAAATGTTCCAGATTCTCCAGTATTGTTAGGCGTACCCCCCCCCCCCCCCTACCTACCTACCATCCTTCCTAGCCTACATGCATACCTGCCTACCTAGACGCCTGCGGCCTACCTTCCTGCGTACGTTTATGTCATACATTTTTTGCCAGCCTTCTGCCTGTATTTTACGTGTCTTAATTACGTGCCTATCTACTTACCTTTCTTCCACGACTACATGTATACCCGCCTACCTATACGCCTGCGTGCCCGCCTCCTGCCTAACTACTCACCTACCTGTTTGCATACATGCCTGCCTACCTTCTTGACCATGCCGAGGCGCCTATACGACTTGCCTACCTACACGCCTGTCTATTGCCTACCTGTTTGGTTACATGTGCCTGTGCCGTACCTGTGCCCAGATCCTGAAAAACATCGTTATTTTGTAATAAATAATTTTAATAAAACTTTAAAAAACAAAAAAAATACGAAATTAAAAATAACCTAACAAAACGTCTTTTCAAACCCCTTCGTACTGCTTGATAAAAATTCGTGTTATATCCTCTTCAACAACTTGAACTGCACTCCTAATCCGATTAGACACAGCTAAACTTTTTGTCGCTTTATTCATGGACAAGTGCGCTCCTGGGCAATTGAGACTATTCGAATCGGTGTAATAGGTGGTGAAGCTCTTTGAGCATCTTAATGTAGAGTAATCTTCTCGAAGACGGCCCAGAATTGCGGTGATTGAGGGATTTGTGATGGATCTGTACGGGATTTGATGTAATAAATTTAAATTGTGTGGTTTAGATGCAGAAAAAAGTTTAAACTAAGAATTCAGACTAAGACTTGAAAGAGAGCCGATTAAAGAAAAGGGCTGAGCTGGCTTACGATTTTTCCCCCTAAGTTTATCTTCACTTATATAGTCTATTATCCCCCCAATACTAAACAGTATATGGTAATAAATACTTTGACTGCAAGAAAAATGAATAATAGGCTCTGCCTCTATATTTGTTTTTTTCGTTTTAAACCCAAACTTATTCTACGCCGAAATTCTTTGATATTTTTTGGAATTATATATCCTTCGATTTATATTCATGATTCCAGCTCAAATTTTTTTTTCTCAGAAAAATTGAGTTTCCCGCCAAAATGGGTTTCTCAAAAAATTGGAGTGATTCTGCCAAAATTGTTTTTCTCTTTAAAAATTTCCGCAAAATTCTGTTTTTCTCAGAAAATTTGTATACTCCCCGCCAAAAACGTTTTCTCATAAAACATGAATTTCCGTCTTTCTCATGAAATTTGAATTTCCCGCCTAAATTTTACGAGAAAATTTGAATTTCCAGCCAATCTTTTAGAAAGTTTGAATTCAAAAGGCTTTTTTTCAGAAAATTGGAATATTCCGCAAAAATGTTCTGAGTAAAATTCTCTAGCCTATTGCTTTTCTCATAAAATTTCACTTGAATTTCCGGTCACCTGTTTTCAGAAAAAGTTTGAATTTCGCGCAAATTTTTTTTCAGGAAATTTTAAACCTCTGGCTTTATTTATCTGAAAAAAATTAAAATGTCCTGCCATTTTTTTAAAAAAAAAATTCACAGAAAATTTGAATTTCTAAATTTAAAATTCACTGAAACTGACTTCCTTATCGACAATTGTCACACGATCCGATGATTTCAGAGCTACACCGCTCGTAAAAATCCCACGTATTGAATCCACGTCATCAGAGTCGGGAATTTCAAAAATTTTACTATCATCCATTTGTTTGCTGGAAGCGTTAATTATCGATTTTTATTTTTTTATTCGATATATTAATTTTATTGATATTTTATGAAAAATAAAATCAATTTCACTCTCGGATTGGTCTGGCTTTGTTCCTTCATAAAATGTAAAGAAAGAGTTTGCCGAACTAGGCCATTTTGGCTCGGATATCCGGGGCAGATTTACGGCGCGTGGCGTCGTGGCTCGTTAAAAATAGATTTATTTGTCTGTGTGGAGTACACGAAAAGGCACTTCTCACGCGTTGTCAGGCAATTGTCAATGGAGCGCGAAAAATTCAATGAGGAAGAAAGGTTCCAGAATCCCGTGTCCCTGAGTTTTTGAAAATTTTTGAATCGAATAAAAATTTTAATTGAAAAGATCGATTTTAAACAGTTTTAAAATTCTTTTAAAATTGAATTTAATATTAATCCCATTTTAAAAATTATTGATTTTCGAGCATACCTTTTCAATTTGTTCGGATGGTCCCCGTGCTAATTGAGCCAAACACTATCGATTAAAGATGGGCGTGTCACCACTTTTGCCACGCCCCTTTTATTCCGATATTCCAATAACCCGACGAATATCTCTGGTTCGTAATTTTAGAGTTGGCGAACACTGTGAAATAGGAATCGAACGCTTTCGGCGAAGATCAGACCACTCGAGAAATGTGATGAAGCTCCCCGGAGCTCTGAATGTTTGGATAAATAGAGTTGTGAGCCTAGTGCAAGTTGAAAAAATCGATAAATTATCGAGTTTTCTGATTGTTTTAGGCGGGAATTCAAATTTTCTGAGAAAAATTTAGGCGAGAATTCAAATTTTCTGAGAAAAATTTGAGGCGAGAATTCAAATTTTCATAGAAAAAATTTTGGCGGGAATTCGAATATTCTGAACAAAAATTTGCCGGGAATTCAAAATTTCTGAAAATAAATTTAGAGAATTTACCTCAAATTTTCAGAGAAAAACGCATTGTGGCGGGAATTCAACTTTTCTGAAGTCAAAAATCTAGTCGAGAATTCAAATATTCTGAGAAAAATTTAGGCGAGAATTCAAATTTTCAGAGAAAAAATTTTGGCGGGAATTCAAATTTTCTAAGAAAAATTTTGGCGGGAATTCACATTTTCTGAGTAAAACTTGGTGGCGGGACTTCAAAATTGTATTTCTGAGAAAAATTTAGGCGAGAATTCAAATTTCCAGAGAAAAAATGTTTAGCGGGAATTCAAATATTCTAAAAAAAAATTTGCCGGTAATTGAAAATTTCTGAAAATAAATTTAGGCGAGAATTCAAATATTCAGAGAACAATTTTGGCGGGAATTCAGATTTTCTAAGAAAAATTTTGTCGGGAATTCAAATCTTCTGAGTAAAACTCTCTGAATTCAAATTTTCTGAGAAAAAATTTAGGCGATCAACTTTCAGAGAAAAATTTTTGCGAGAATTCAAATTTTCAGAGAAAATGCGAAATTTGGACGCGAATTCTAATTTTCTGAAAGGAAAAAAACTTCGGCGGGAATTCACATTTTCAGAAAAAAAATTTTGGCGGGAATCCAAATTTTCTGAAAAAAAATTGGCCGGGAATTCAAAATATTCGAAAAACATTTTCGGCGAGACTTCAGGGGTTCTCATAACGAATTCAAATTTTCTGCAACAAATTTTGGCGGGAGTTCAAACTTTCTGAGAAAAAATTTGCCGGGAAAAATTTCCGAAAGTAAAGTTTGGCGGGAATTCAAATTTTCTGCAAAAGATTTTGGCGGGAATGCAAATTTTCTGCAAAAAATTTTGTCGGGAATTCAAATTTTCTGAGAAGAATTTTGGTGGGAATTCAAATTTTCTGAGACAAATTTTGGCGGGAATTCAAATTTTCTGAGAAAAATTTAGGCGAGAATTCAAATTTTCACAGAAAAATTTTGGCGGGAATTCAAATATTCTGAAAAACAATTTAGGCGAGAATTCAAATTTTCTGAGTAAAATTTAGGCGAGAAAATTTCGAATTTTCAGAGAAAAAATTTTGGCGGGAATTCAAATATTCTGAAAAAAAATTTTGGCGAGAATTCAAATTTTCAGAGAAAAATTCTGGCGGGAATTCTTTCTAACAAAAGTTTTGGCGGGAATTAAATCAAATTTTCTGAGTAAAACTTTGACGGGGCAAATTCAAATTTTCTGAGGAAAATTTAGGCCAGAATTCAAATTTTCAGAGAAAATATATTGGCGGGAAAAAATCATTCTGAAAAAAAATTTGCCGGGAATTCAAAATGTCTGAAAATAAATTTAGGCGAGAATTCAAATTTTCAGATAATGGAAATCGGTCGAATTCAAATTTTCTAAGAAAAATTTTGGCGGGAATTCACATTTTCTGAGAAAAATTGTGTTGGCGGTAATTCAAAATTTCTGAGAAAAATTTAGGCGAGGAATTCAAAATTTCTGATAAAAATTTTGGCGGGAATTCAAAATTTCTGAAAATAATGGCGGGAATCCAAATTTTCTGCAAAAAATTTTGGCGGAATTCAAAATTTCTGAAAATTTGCCGTGAATTCAAAATTTATGAAAATAAATTTTGGCGGGAATTATTTTCTGCAAAAAATTTTGCCGGGAATTCAAATTTTCTGCAAAAAATTTTGGCGTGAATTCAAATTTTCTGAGAAAAATTTTGGCGGGAATTCAAATTTTCTGGGAACTGTCAAATATTGGCGGGAATTCTAATTTTCTAAGAACATTTTGGGCGGATTCTAATAGCTTGAAGTCTGAGAACATTTTTGGCGGGAATTCATTTTCTGAGAAAAATTGTGGCGGGAATTCAAATTTTCTGAGAAAAAAGGCGAGAATTCAGATTTTCAGAGAAGCTCAAAAATTTTGGCGGGAATTCAAATTTTCTATAAACCAATTTTTTCAGAATTTCAGAAAACACCACCCATCAGAGCGCGTTTTCAAGGTCTCACTGTATTATTCACTAGGCTCCGAATTTACAACAGTGACACCTCCGAATTCAATTCCATCCATTATTTGACTTCCTATAAAAAGAAACGAGTCAACTGATATTCCTAGTATTGAGACGCTTCAACTCTTCTAGAAATTCGAAAAACGGGCGACGTAATAGTTGCCACGTATGTTTGGAGATGGCCGCCGAAACTGGAAAAAAAATCTCGTTTAAAATAAACTGACAAGTCTATATATTTTTTCTTTAAATTTTTTTATTCGAAAAGCACCCCTATTATATAAATTCTTTTTTAACCTACCATTTTTAATATTTGATAGCCGAGTCTTTGTTAGGCCATGTGCAAAAAGCCGGTCGGTACCGGTTTTTGGTGACCGAATTTTCAAATTTTCTAGGCCACGTAGAAAACCAGGTCTTCTTTTGACACATTGATTGTTTAATTTTCTCAATACAGGACCCTCTCCTATAAAATCACGGTTAATTATAGGCGATAAGACGCCTATGGCCGAGTTTTGTTTATCTCTAGGTCATGTAGCAAAAACTGGCGATACCCTTTTTAACCCCAGAATGTTCTCAAGAATCATATTTTTTAATTGTGGTAAAGGCCCAGAAAATTATGTCTGCTGAAATCACAAGTCGGCAGCCTTCTCGCTTGCCAGGTCGTCCACGCTGCAAAAACTCTGTTTACATATAGACCTTTTCAAATAATTTCAAATAAAAATTAATCACTTATAAAATCATTTACTTCAGGATTGAAAGCTTTTGCTGGTTAAAACCGGAAATAAGTCGATACGGCCGAGTATTCTCTTTTCTAGGCCACGTACCAAAAGTGTTCAGATTTTCCCCAGAAAGTTGTCAAAAATCGTATGATTTGTGGAAAAGCTCAGCGTAAAACTATGAAAAAATGAGTCAAATCGGTGGCCGAGTTTTCTCTTTTTAGGGCACGCTGCTTAAACTTCCATTTACATTTTGGCTTTTAGATTCAAATAAATATTATTCCCTCATAAAATCGTTTACTGTCATTGTGAGAGCGGTTGAAAACAAAAAAATGGTGGCCTTTTTTTCTAGGCTACATAGCGAAAAACTCACCTAGTATACACATGAGCAGCTAACGACACATTCTGCCATCTAACATTATTATAAATAGGCGGATTACATACCAAATCCTTCGGATTATTATCCGCCTGCAAATATCGAATTTTTGCGGTATGCCCATTAAGAAGCTCCGGCTCCGTGAGCTCTTCCTCAAGCACTATATTACCCACAAGTGTCACGTATTGGTAATACATAAATTATGCGGAGTTGCTCTGTGGATTTGAAGTGGTTCGAGTACGGTTTTTGTGTCGTCACTTCGGTTTGCGATAATTACGACGTTCCCAGCATCCCCAGGGGCGATAAAGGTTAGTGTTATTTGGTTTTTGTAGAGACTGAAAGAGTGGTTTCAACTTGAAAAGTAACGTAGTTTAAAACATATTCTTCTTTTTTTATTCTGAGATATTTTGATTCTGAAAAAACAAAATTTTTTTTAAATAAAATTGGCAACCTCACAAACTGTGAGTTTGTTGAAATTTAGTTTTTACAACCAATTAATTTTTTAAATTAAAAAAATTTTACGTGTAGTCCTCTAGAATAATTTTAAAAATATATGAATAAGTGTTGAATTCTGCCCAGTTGTTTTTTTTGCCGGTCGCCGAGTGGACTAAGTGCAAAAATTTGGAATTTTTCAAACGGCTTTATATTCAAATCATCAACAACTTAAAAAAATTTAGATTAAAAAATTTTTTTTGGAAGTTTTCGAAAAATTTTGGAAAAATTTTTAATTTGATGTCAGAAAAAAAAACCAGTTTGATTTTATTTTTCTTAAATTCTTTTTTGAAAATTTGTTGAAACTTTTTTTTAAATACTAGACTTTTTTTTTGAATTTTCACGCTGTTCTGGTTTCCCTATTTTGAGATAGAAGAGTTTGCCGAACTAGGCCATTTTGGCTCGGCCATATCTGGGGTAGATTTACGGCGCGTTGCTTGTCGCGTCGCGGCTCGATATTAGTTGAAAAACTAAATGTATTTGTCAGTCGGTACACGACTTTCCCACGCGTTAGGCGATTATCAATGGACGCGAAAATTTAATGCAATGAGGAAGGCCGGAACCCCGTGAAAAATACATTTTAAAAAATACATGAAAAATGTTCAAATTTTCTTTTTAATTCATAAAATTTGAAACTACGTTTTGTAACTTTACAAAAAGATAATTTTTCGAAATTTTTTTGAAATATTTTTTTTCGATTCTTTTTGTTGATTTCAATTCTCTTTTCTAAACATTCAATATTCCTTACCTGTATCCCTCTAGCCATAATAGTACGCAGAAACAAAAAATGTCTTCGTACGTTGTTATCCAATTCTTTAATCTAGTGTATGAATTTCGAACACGTCTTAATGCAGGCAAGGGATGTATTCAAATATCAGTACAAATGCTAATAATATTACGATATAGGGTCCTGCAACGAATTCTCAACTGCTGGTAGAGTACGGAATAGGGTTTGAATTGAAAATTCCTTCGTACAGTTTCGTGTCGGAATTCATTTTTATTATGGGAGGAAAACAATCTAGTGGTGGTAGTGGTAATGTCAATCGCTAAATCGATGTTGAATAGCACACTTCCGATAAGTATCGGGCGCCAGCGTGGCCTAGGATTTGGGAAAATTCTTCCACCAGAAGGTAGTCCCAGGCTTTTAAATATGATTATTTCATCAAGAAATTTACAACTAAATTGAAAATCAACAGTTAATACATTTTTTCATAGACTTTTCGAAACATATCTGATTTTTACATATCAAATAACCCGGTACGCATCTAACCGTCAGTTGCCTCGTGGCCTAGAACGTTTGCAAACTCTTTCACGAGAAGACATTTCACCGTAGCCTAGTTACTAAAGCTTTGAAACTTCTTGCGTGCAGTTCGCTTGGAATTTTTGCTTGTTTTGTCAACTAACTAGGATTCAATAGCTATTAAAAAGTTTCAAAATTGGGCAATTTATGTAAAAATTCACAATTTTGAAACTTCTCGAAAACTAGACGATTAATTTTGGTAGTGGACTCAAAATTGATCTTCAAACACTAAAAAATAGCACTTTTGTAGAATATATTCCCATAAGATTTTTTGCAAAATTATTTTTTTTTACCCAAAAAAAAGGACAGTCATGGCTGAAATAAACTTTGGAAAAAATAAAAAAATTGTCTAAATTTGCTGAGGGTAATTCATGCATTCTGAAAAAATCTGGGTTTAACCCATCAAACAACATTAAAAGCGGCATGGGTATTTCATTGTAAAAATAATGCATATACAATAAACAATGTAGAGGTAGGTGCAAAATCTGTAGTTTCTTTGAAAGATTTTTTATTTATTTTTTTGTTATTTTTTTTGCAAATTTTCGTATATTTAAGTAGTTAGTTTGCATGTTACATGCTAATGAAAAGTTTGCATCTGCTGATACATATAAAAAAGCGCCGAGAAATTCACAATTTCAGTAAACCATCAGTAAGGTATTTAATTTTTGTAAACTTTAGTCTTCTGCTCCTCTAAAGCTTCTGGAAGAGGACACTTTCTATATCTTCAAAATATTTTTGTGCGCCACTTTCCTGTCAAATTTCTGGCATTATTACATCCAAAAAGTCCCCATAAAAATCGGAATTCCATGGCTACGACAACGTCAGCAAAAGCGGAAAGAAATTTTATATGCCAGTCTAACGAGTCACAAAGCATACACTGACGTTTCTATCAGAAAAGACAGGATATCGTATCAAAACAAAAATTGGGTGCGATTGCTCGATGCACCATGTGATATTTTGCTTTTTTTAAAAATTATTTTGCTCGTTAGTATGGTGCACTTATTCCGTGGGAATGCACGCGGTGTCATAATGCCCATTTCGTTGATGTGCGTAGATCTACGGCAAAAAAAAGATTGCGGGAGTTGAGACGCAGAGGTAGGGCTCAATTCGTGTGGTTAAGAGCGTGCTGACGTCACATTATGGGCAAAAAATTCCCGCATTTTTTATAGATCGAATAAACCGAAATGGCACATCCTGACACCATGTGAATGCAAAAGACTTTACGCGGAACTTTTTAGATTTTGTTACTAATAATCTTAGGATTACCAGTGCTATGGTTTTATAGAAAAATATCAAAAGCGTTCAAAAAGAAATCAAAACATTTTTTCAAAATTTTAGATTTCCACTTTCTATTTCAACTTTAAAAGACTTATTCAAATTTTGTTTTGTTGATTCAACGATTTTTCCGCATTGATCTCACCAAAAGAATTCATCACATCATTCAAAACTAAAAACTCACTTGGCTTTCATTCCGCTCAGATGACAAACTTTTTGGTGGCAAAGGTTCTTTGGGGGCATAGTATCCAAGGAGACAAGCATAAGTATCCAGTAGACAAACTGGGGTGTATCTTGGGGGGCATGTATCTTTGGTGACAACCTTTTTTTCCGACTAGATTTTTATATGTACCTTTTTCAACTACTTTTCTATGTTCACATTTTTCTGAATAAGTTTTTTAATGCAATTTTCAATCGATTATCGGTGATAATTCCCTCACCATTGAATGTATGAACGATGGATTCTTTTGGGAAAAGCTCTAGAACGTCCAACTAACTTGGAATGATCGTGCTAAGTCTTCCCGATGGTCTGATCCTTCAGCTCCGAAGGATCAGATGTGTCCCTTCATGTTCTGATCCTTCAGACATAAGTAGGATCGTAAGGGTACCTCCTGATGGTCTGAACCTTCAGATCTCGGCCAAAGGATCACGGGGCTCTTCCTGATGTTCTGTCAGCTAGGATCACATGGGCACCTTCAGATGATCTGATCCTTCCTGCAGATAAGAAGGATCGTAAGGGTGAACCACTTGATGGTCTGATCCAGCTCCAAAGTTTGAGATCACGACGCCCTTCCTGATGTTCGATGATTTCATCTTCGACAGATCATATGGATTTTTGACAAAATTTGAAAAAAAATTTTGAAAAAAAACTCGAAATTTTTTTTTGTTATTCTCCCTCTGCCATTCTTTAAAGAATAGTGCAAATTTATCATGATAGGACCGAATAACTTTCAAGAAACAGTATAACTATACATGATAATCACGCTTCTACCAAATAATGATAAATTCTCCGCGATGACAAACTTTTCGGTGACAAAGTTTGGTGGAGAAACAAAAATTACCGATACTAAACTGGTAGGTAAGGAGAATAGTGAAATAATAGAGTCCTACAATGGACTATTAAACATGTTCAGTAGGTCAGGACTCGTCCGTCAAAATAAAAAATTTGTCAAACGAAGTTCGAAACTGGGCCCTGTAGGATGGAACAAAGGGCGCTCACTACCACTACACCAACTATGCGAAAGTCGAGCCTCATCGAAGGCTATTATAAAACATAGTTCGAACGAGTATGATCGACATTCCACAAACAGTAATATCTCTCAACAAGAATCTCTTCAGGGAATTGAGGTCATTTCCAGTGACTATTAATTTATCGGTTTTTTCTCAAGTTGAGCATAGGGTCTTTTAATTTTTTGAACATAGAAAATCACGAAAGCTGCCTGTGCCCTGTATCCATCACTGGATCGAAATAGACGTAGCTCTGGCCTAAAATATTTCCTGAACAGTGATCATTTCATGTCCATTGTGTGTTTCTCTGTATTTTGCACCAGAAAGTTGAACAAAAATGATAATATTATATCGAATAATGGAACAAATACAAATAATTCTGACTAATCAAATTTCCTCCGGATATTGTTTTTTCTGTCATGATTATAAGTTTCTAAGTTTTTTATAATGTGTTTACAACGTCATAATTACCTTCCTTTCAAGCAAAAACCGTTCGAGGCGTCTTAAAAATAGATGTGCAAAAAACTTAATTCGTTTCGATGAACACCATACTACGGTCGGTGTGACTTGGCGTGGCGGTTTGCTTTTGAATCATACTATTTGACCCACCAAACTAAATTAGCAATGAAATTATTTACTGCAAATTCTGCATCGAAAAGGACATTACGATGGAAAAAATGACGATTTTAATTATAAAGCAACACATTATAAAAAATTTAAGAACATATAATCATGACAAAAAAAACAATGTCCGGAAAAAATTTGATTAGGCCTAAAATAAGGTTATTTACTCCTTTTTTTCCAATGTTTATCGATTCAATATCAACATTTTTGTTCGACTTTCTAGCTCAAAATTCATAGAAACTCACGATGAACATGAAATGATCACTCAGGAAATTACTTTAGGCCAGATACGTCTGTTTCGATCCAGGATACAAGGAACAGGCAGCATTCATGATTTTCTATGATCAAAAAATTCACAAAACACCCTATGCTCAACTTGAAAAACCGATGTCGTAAAAATAGTCAAATGACCTCAATTCCATTAAGATATTCTTGTTGATAGATATTACTGTTTGTTGAATGTCGATCATACTCGGGCGAACTAAGTTTTATAATAGCCTTCGAGGAGGCTCGCCACTTTCGCATAGCTGGTGTAGTGGTAGCTCTGAGCACACTGGTTTGCATCCTACCGGACACCAGGTTCGATCTTCGTCTGACAAACTTTTTTTTATTTTGACGGAAATCAGTAAAACACCTACTGATGTTTAATAGTCCATAGGACTACTCTATTTCACTATTCCTTTACAGTTTTCGGTAATTTTTGTTTGTCCACCAAGATACTTTGTCACCGAAATGTTTGTCATCGGCGAATTTATCATTATTTGCTAGAAGCTGATGATCATGTATAGTTATACTGTTTCTTGAAAGTTTTCGGTCCTATCATGATAAATTTGAACTATTCTTTATAGAATGAAAAAAACAAAAAAAAATTTCGAGTTCTTTTTCAAAACTTTTTTCTTTCAAATTTCGGTTGTCAAAAATCCTTATGATTCCGTCGAAGCTGCGAAGGATCAGAACATCGTAGAGGAGGTACCCTGATCATTCGGTTATCTCTGAGACAAAGAGATCATCAGGCAGAGCCTCCTGTTCTTTTGGAGCTGAAGGACACAACATCACGAAGAGCCTCATGATCCTTCTGAAGTAACAGACCATCAGGAGGTACCCTACGATCCTTCTTATCTGAAAGATCAGATGTCCCCATCAGAAGGTACCATGTGATGCTTCGGATCGGAAGGATCAGATAGGACATCAGGCAGAGCCTCATGTGCTTTTGGAGCTGAAGGAGAACATCAGAGCCTCGTGATCCTTTGGAGCTAAAGGATCACACCATCGGGAAATCAGGTACCCTTACGATCCTTCTTATCTGAAGCATCAGAACATCAAAAGCCATGTAATCCTTCGGAGCTGAAGGATCGACAGACCATCAGGACGAGCCTAAACATGGTATTCCAAGTTAGTTGGACGTTTTATCAGCTATTACCATCGTTCATACATTCAATTGTGAGGGTAACCGAAAATCGATTGAAAATTGCATTAAAAAGCTTATTCCAGAAAAATGTGAACAAAAATTAGCTGAAAAATACATATAAAAATCTAGTTGAAAAAAAGGTTGTCATCGCCAAAGATTATGCCAGATACCCCGTTTGTCTACTGGAGACTTTGTCTTGGATCCCCGCCAAAGAACCTTTGCCACCTAAAAGTTTGTCATCTCGAAAGAAAGCCCCCCGACTCTGCGCGTTATGGTGAGACCCTAATACGTCATGTTTGACCCGCAAAATATCTCGTAGCGAAAAATACAGTTATTTTTTAACCGTATACTGTAGCGCTGTTGTAGAAGTTTACGGGATCTCTATTTTTCTAATGATTAAAATTAACAACAAATCAGAAGAATGACCCTCACACGAAGAAACGAAGAGAATGAAATATCGATGTCACTTTTCGGAAAAAAAATTAATTTCAAATGAGCCCGTAAATTTACACATGCGCTACGGTAGACATTTAAACAATTACTGTAGTTTTCCGCTCCCAACGAGAAATTTTGCGCGTCAATAATAATATATCGCACAATAAGCATTCTCAGAATTTTGCATGTTCCCGGAATAATTTATTTAATGGTTTTTTTGGTTGTTTCCTATTGGTCCCAAAAATCAACAAAAAAAAATTTGTTATGAAAAATTTCTGTTTTCTTCCGTTTAAAATCAAAAGTTTTTTTAGTTGCTTTTTTTGATAAATTTTTGCAACCACCCTGATTTATATCCCGATAAATGTTTAATGTCCCGCTTATGATATCTGGAACTGCCTCTTTGCACGTAAAATTCCTACCTGCGGACCAAACACACCATACATCACGCGCACTTTTTTTTTTTTCATCTGGACAAACACATTTTCCGCATGATTTCACTGACTTTATTTAACTCTCATCACTCGTATCGTTAAAAAATGCCCTAATCATCAACCTATTTTCATTGTCATTCAAAAAAAAAAACTATTTCGTACTCGGCGATCGTACTAATTTGTCATCATTGCGTTCCGTCGAGCAAAAATCAATCGGGAGTACTTTTACGTTTTCCGTTGAAAAAAAATCCAAAAAAAACACCATCCAAAAAAGATCCAAAAAAATTCCTAGTTAATTAAAACCGGGAATAAAAAATTCAAATAAAAAGTTCAAACGTTTCGTTATAAAAATGTACACCGGTAAGCTGAAACATATACATTTCATAAAGATTCTAACAATGTGCGACGATACGCTCGCAGTTTGTAGTCCAGCTCCATTCAGTGATGATGTAGAGGTTATTAAACAACAGGCGATCGATTATCCCATACAAATCACTCTGGTAGCGATTTCTGGGAACGGTAAGCCGTGCGCTCCGTTGTACTCATAGTTCGATGAATGAAGGCATCCGTGTAAGTTCTCAAATTTTCAAATGAAAACTGCCAAAAAAGGTTTTTAGTTATAATCTAAGAAATTATCGATTTTTAAATTTTATGAAAATTTTTTCGAAAAATTTGGGTTTTTTGTTTTTGTTTTTGATTAATTGATTGTTCGGCAAAAATGTCAAAAATCGAAAATTTAGGTATTTTTTCTTGGGATGAAAAAAAAAAAACTTTATCCGCCCGGCTAAGCGAAACTTGTGCTTTTTCGGTTTATTGATTTAAACCTTTGATTTACTGGAAAAACTTGAAAAAATCAATACTTTTATCACTGCGATCTGGTCTTCCACTTTAAACCTCGCGCTCCATTGAGAATCGCGGACAACGCATCGCGGGAAAGCCGTGTACTCCACACGGACAAGAATACAATTAGATTTACAACTAAAGTGTGACGAGCCGCGACGCGACACAACGCGCCGGAAATCTACCCCAGATATGGTCTGGCCTAGATCGGAAAAAACTCTTCCATTTCAATTTTATTATGAGGGAAGCCAGAAATCTTTGTTTTTATTTTATGCGATTTTGCTCTAAATTATCGATTTTTTGGAAAAAGTTTGAAAATTCCATAATTTTTTAATGATTATTGGAACTAAAAATTAAAATTTTCACAATGCTCAAAAACAAAAATTACTGATGTTAGATAAAAAAAACACGGCATGCAATTTCTAGACCACCGAAACTATCAAAAACCTCTTCCAGTGACTCGTCCGGTCCGTCTCTACGCAGACGGTGTCTACGATATGTTCCGCTACGGCCACGCGAATCAATTCCTGCAGATCAAACAACCTCTTCCGAATGTCTACCTTATTGTTGGCGGTGAGTTCGGCCCGCGCAATTCAAAATTTTTAATTTAAAAAAAAAACGATTTTGTCCAGTATGGTCCGAAGAGTCTATGAAGAATAAGGGGAGAACTGCAGGGCAAAGGAGAGCGGTTCGAGGCGATTCGGCATATTGTGCCGGTACGTCGACGAGGTGTATCAATGAGGCGTCGCCGTGGATATCTCCGATACCGTTTTTTGAAGGAGGGAGGTAAATTGCGCGTGAGATTCGGTGTTCGCACAGTTTTATGTCCAAGAACGAAGGAAATTTTATACCTAAATTTCGGAGAAAAATCATCAGTATAAATTATTGCCTTTTTTAAACGTCACTCACAAAATCGATAATAAAAGTTTGAAAATCACAGTCAATTTTTATTTTCAAAATTTCGTTGTTCTATCACGGGAACGCAAATTTCTCAGCATGCGTACTACACAACACATTTGACGCGCAAAATATCTCGTAGCGAAAACTACAGTAATTTGTTTATTGACACTGTAGCGCGCTACTGTCGATTTACGGGCTCTATTTTAAGCTCTTTCTATCGATACATATAGGATACATATTGATCCCGTAAACAGACAGCGCGCTACAGTAGTCAATTAATGAGTCACTGTAGTGGTCTTTCACTGCTACAAGATATTTTGCAGCCTCAGACATGTTGCGCAATAGCATCCTCAGAATTTTCTGTACCCCGTAACAAAACTTCGAGTTTTTCGAAACAAAAAGTTTAATTTAAAAAACCTCTAATCTTCGAGATATTCGAGTATTGATCTATTGATTTTTCGATAAATATTTATTTTTTTTTTACGATATTCGAAACAATTATCGAAATTTCAGAACTAACAAAAAACATTTGCGGAGGAAAATCGATAACATTTTCAAAGTATATTTTGTGTCCATAAAATTGATTTTTCCGTAAATTTAATTTGTTTGATTTTCGGGTTGGGTTCGTATTCCTAATTTCGGTAATTTTGAGTCGATAATTTTTTGTTTTTTTTTTTCAATTGAAACTTTTATTGATCAAGTTTCTGGCCAGTGCTCTTATAAATTGAAATGAGAAGATTTGGCCGAACCAGACCATTCTGGCTCGGACATGTCTGGGGTAGAATTACGGCGCGCGCGTCGCGCCTCGATCCTTTTAGCTTGTAAAACTACATGTATTTGTCCGTGTGGAGTACACGACTTTGCGTTGTCGAGCAGGTGATTGTCAGATGGAGCGCGTACAATGCTATGAGGAAAGCCAGAACCCCGTGATTGATTAGTTTTTGACTTAAAAACCTGATTTGAAAGAAAATATCGGTAATTTTTCGGATTTTTAACAAGAAAGGTCTTTATTTCCGGAAACTTTCATTTGATAATTATTTATTTATTGGTTTCTCGGAAAAATTTGCCGAAATCTATCGATAGTCGGACAATTGGACGAAAAGTCGAAAAAAAAATTCTAGGCCACGAATTTCCTCTTCCAGGTTGACTTTATGTCACACGACGCTCTGCCATACCAAGGTACCGCCGGAGAAGACATCTACGAGAAGCACGGCACTGCTGGCATGTTCCAGGAGACGCAGAGAAGCGAAGGAATATCGGCGAGCGATTAGATTTGTCGAGATTATGTCAGCGACTACGACACGTATGTCAGAAGAAATTTGCAGGTGAGAGGATATTCGGCCACCGATTGGAACGTTGGCTTTTTTACAGTGAGCCTGGCCTAGAAAGGGGTGGCCTAGAAACAAGTGGTGGCCTAGCAAGACTCTTCCATTTTTTTCAGACCAGCAAATATAGTCTGCAAGACACCGTAGTGGTGAATAAAAGAATTGGGCCGTGGCCTGCTGCAAACGTGGAAAACGTTTTGAATTTATTGATTGAAAGAATCTTGACGACCATTTGCCATCGTGATCTTCAGCGAAACCGTTCGAACAACAAAAGGGCCGATGAAAATGTGGAAAATAGGGAGAATATTGAGTTTTTAAAGAAAATTCGAGTAAATTATGGGAAGAAAAATTATACTCGTGAAAGTTAACTGAATTTATGCAATTTATTTTTTGAAATTCTCAATTTTTTTGGAAAATTTTTTTTTCTTAGGGCTTAGTCGAACATTTGGCTTTGTTTTAGGATTAAGGCTCATGCTTAGGCTAAGGCTTAGACAAAAACTTAAGCTTAGGCTTAGGCTTTTGATTAGGCTTAGGATTCAGGAGTCGGTGTCTTTCACTTAGGTTTGGCGTCATTGGCGAGCGTTAGCTCGCTATTTAGGCTTGGGTTAATTAGGCTTAGGCTTAGGCCTAGATTTAAACTTTTAGGCTTAGGGTTAGAATCACGCTGGCTAGGGGAAAAAAGAGAAATTCCAAAAATTCCAGGTTAAACGTAAAAAGGACAAAAAGGTACATCCCGAAGTCGGGTCAAAAAATAAAGTGATGAAATGTTCGGGATACATGAATGAATATTTCTGAGTCTCGCGGATTTATTTTCATAATCATATTCTGAACGTATTATTGACTCGTCGTGTGGGACATTTCAATGGATTTTCCATAGAAATCTCTGTAGAATTCCGCCATCGGCCAACGATTCTTCACAAGAGCCAAACTCGGCGAGTCGGTCAATGTTTGAGCTCGTCTGAAGAGTTTCAAAATATATGAATTCATTTATCTTGCAAACCTTTCACCGTTTGTGTTCAGTAAAAAGTCCGTCGGGGCAGATTTCCGTATCATCAGACGATTTGCATGTATACAATCCACATGAGGTTTTGTTCGCCTTTAGAATTTCTCCCAGTTGCCTGGAACGTTAGTTTTTCTGAATTTTTTGAAAGGTATAGAGATAGCAACAAAAAAAAAAATATACCCAAATAATGAGCTATTTAATCTAGGGGCTTTATTACAAATACTTTTCTAAGAACGTCTTGGTCTTGATAAATGCGTGCTTTAAGAAAAAAAAAAGTCAAAAATAATAGCGAGTCCTCAGATGTCGGGCGTTGTACTTATTAAACTCGGGGTCAATAAGTTCCGGGTCAAAATTCATAACTTTTGCGTAGCAAATCGATTTCCTTAAATGTGGGACTTTATGTTATCAAACATGGTCTTTTATTTGACGGCACTTTCAAAAAGTTTTGCCCACTCCATGTACCCAAGCTCGGATCCACTTTTTTCAGGCGTATGCCCGATCTCGCATTTTCTTTGTAACTTTCAATTGAGACTTTTGTGCGGATTTTGATTAATTAAATATACAATGTAAGAATACAATAAAAATTTGAGAAAAAATTCGCTCAAAAAAACAATTTTTTTGATCGGCAAAAAACTTAACCCTCGAAAAAAATTTTGTCGCCCAAATCTCTAGGTTTTATGGAATGATGCAAACAATTCTGAACAATTATTTAACACATAAAAGTTTTTTGGATTTAAGGCGTCACACACAAGCGGCAATGGAAAAAATGATTTTTTAGTGAATTTTTTGAAATTTTTGAGAAATTCTCGTCTAAATATTAAATTCTCAAATGTTTTGTGTGTCGAAAAATTGTTCAGAATTTTGCATAATTAGTCTCCTGTACAAAAATCCAGAAATTCCGACAAAAATTTCTCCGAGGATGTTGACGAACCTAAAAAATTTGTTTTTTTGAAGGAATTTTTTCTCTTTATTGTATTCTTACATGTATACTTAATAATTCAAAATCCGCACATAAGTATCAATTTACAGTTTCAAATAAGCAAGATCGGGCATACGCCTGCATAAAAAAGGATCCGTGCTAGGGTACACGGATTGGTCAAAATTTTGAAAGTGCCGTCAAAGACCATGATAGATAACATAAATTCCCACGACTTTTAGAAAAATCGATCAGCCACCCGAAAAAAGTTATGAATTTTGACCATGGTATCGAACTTTTATCGTGTGCTACATGCTTGTCGCGAAATATACCTATTTACCTATACCTGTACCTATACCTGCTTCATCTTTCGATATACGCCGTTCAAATTGTGGAGCATCTTGTCCAAATCGTCGTATCCTCTTCCAACTCCCAGGTAGATTAGTTGTTGAATCTACAATTTTATATTTAATTATAAATTGTATATTTTTGTAATTTAAAAAAAAACCTTTCGAAATGCGGCTAAGTAATCAATAATATTGACCTTAATGCCATGGGTCCTCATGGAATTTTCTGCCCATGCACAGTGTAGGAGAGCTCTTCCACTCCGTTCCGATCGATCAGCACATTACTTAGATAAATTAAGTCCCTGTGCTCGAATTCAAGAGCTGCTTCAGCTGCAACCATTGAGAGACCACGAGCTGGTGAATGATGGAAAATAGTTCATCTTCACTTTCAAGGACAAAATCTGCCAGCGGGGAAAGATTCCACCATTTGCCGAGCCGGCTGAAAAGGATAAAGTTTTGATGTTCCTGAAGAATAAACATCTGGCCTCAAATGTTCGGATTCATTGAGCTTCTCGTAGGCATCCCAAGCTCTCAGTAATCCCTTAGGATTTTCCCCTATGACTATTTGGGCTGAAATCATTTCGATAAAATTCGGCATAGAATTCCAAGAATTTGGGTCTCGAGTATCACGCCGACAGTGATTTCCTTGCCCATCACAATCACCTCTGACAAAACGGCGTGGGTTGTTGGAATCTCCACGGATTGATTTCCATAGAAATGCACGTTGTTTTCGAATGGCAAAACCTTTGTTAGCAACCGGTCTACCATTCGGCGCCAGACAGCTGAGAAGACTTCACCGTAGGCTCCTTCGCCGAGCTTCCTTCACTTTTCGAGCATCTAGCGCCGACGTTGATAGGCTACCCCATGGTTTTGCTTCTTTTTGGGCCAACAACACGGCGAAGTTGTGCCATGGACGGATCTTTTTTGTGAAATGTGATACTGCCAATGGGGATATTTCTAGAATCAGGATGAGCTGACCGAGCACTTGGAGCTCATTTGTTCCAGTTCAGCAAGCATGCACAGTTCGAAAGGATGGACAGTCCGAAAATGACTTTTCTGAAATTGTCATAGTTCATTGTGAAAATTCGTTTCGGCTAAAAATGCAAATGCATTATGTTTCTGAAACTCACCAGTTGACTCTGAAATCGTCGTTCGTTGTCATGTCGAGTGCCAAGAACGGTGGTGGTCACCACTGCCGTCTTTGTGAACCGCATCCAAATCGACAAATGTCTCGGGAGTTAACTATAGAAATGAAGTTTTGAAAAATTAAAAAACTCACAATTATTGAAACACGTTATTAGGCCAATAACTTCACACGTGAATTAATACATTCATGTATTCGATTTTCTCTGACTGTTATCACGGGTTTCTGGCTCACGGTAGTTCAGCCACGGTCCCAGCACAGAAAATAGATGTCACGTTCATGACGAATAATCAGTCTGAAAGCTATATTGGCTGCTATCTCGAAAACTCTCTAAAAACGCGTTTTGAGAAATTATATTATGATTTTTTGGAGAAAATCAGAAATTATTGATTTTTTTGAAGGAGAAAATGGGAAATTTTTCATTTTTATTGGGGAAAATCAGAAATTATTGGTTTTTGGAGAAAATCAAAAATTACGATTGGTAATTTGAAGCAGGGGTGGGCAGCAATTGCCGTTCGGCAAATACGCAGATTACCGGCCGATTTTCCGGGTTTTCATTTACGGCAGTTTGCCGGTTTTGCGTTCAATTTGCCCGACATTTTTCAATTTCTCCGGCAATTTGCCGGTTTGGCGATTTGCCCGAATTTTTCAATTTAACCGGCAATTTGGCGGTTTGCCAATTGGCCCGACATTTTTCATTTTCGGCAATTTGCCGGTTTGCCGATTTGCCTTACCCGAAATTTTCAATTTCGTCAATTTGCCGGTAATCGGTGCCGATTTCCAAAAATTTTCATTTTCGGCAATTTGCCGGTTTGCCGATTTGCCGGAAATTTTCATTTTCGGCAATTTGCCGGTTTGCCGATTGCCCGAAATTTTTCGATTTCGGCAATTTGTCGGTTTGCCGATTTGCTACGGAATATTTCATTTTCGGCAATTTGCCGGTTTGGCGATTTGCCCGACGTTTTTCAATTTCGGCAATTTGCCGGCGTTTTCCGATAATTTGTCGAAATTTTTCATTTTCGGCAGTTTGCCGGTTTGCAGATCTGCCCATTTAAGTTCGGAACTCAGATTGGCGGTTTGCCGATTAGCCCGAAATTATTTAAACGGCAATTTGCCGGTTCGCTTTAGCCAGAAATTTTTCAATTTCAGCAATTACAATAGAGGTCGATTTACCATTCAGCTGCCGGAAGTCTTCAGAAGGAATTTTTTATAATAAGGAACCACTAAACACAGCGTTTTGAAACTTTTCCACGTTTTTTAAAGATGATTTCATAGAATTTGCTTACTTGGTTTGTCGAATTGCCAGAAGTTTTTCAATTACAAGTTGGCAATTTCCGGAATTTTTAATTATGGCAATTTGACGGTTTGCCGAATTATTTGCCAGAAATTTTTCAAATTCGCCAAATTGCCGGTTTTCCGATGGAACTTTTTCTCGGCAATTTGTCGATTTGCCGGAGTCTTAAATTTTTCCAATCAATTTGCCGATTTGCCGGAAAAAAAATTGTTTCCCGCCCACCCATCAGTTGATGAATTCATCGTTCTTTTGTGTGTTTGTACTCCCATCAATCTTAAACTCGACCCGGACTGCAAAGGCATATTTACAGTTTTCTCTTCTGGTAGTGAAATGGTGGTCTTAAGTTTCGAAGACTATGCCCACGTAATTTCTAAAGTATTTATGTTTTGCAATTGTTTATCAATGACCCTAAAAAACAGACAAAGCATTTCCGCGTGGCAAATTATCAAGTAACTTGCCTAGGCGAATAGTACTGATGTTATAATTTTTTTTTAGAATCAGTTTGGAATTTCGAATTTTTCTGAAACAACCGCCGGCAAAATGAATTACTGTGAGCACTTTTGATTGTTCCCCGGTTTTCTTGTAGATTTTTGTGCAAAAAATTTCGACTTTCAGCGGTAAAAAAAATACAAAAAGGTCGAAGAAGAAGGAAACGAGCAACACTGCTTCTTGGTCAGGAGGCCCCAAAACCAGGGGGAGCAAAACAAAAAACCAAAACCATCGAAAGGAAATGCGACAGGGGTCGCGGCGAACCGGAATTGACTGCACATCGAAAAAAACCAAGACAGCAAAAAAAGTGAGACAGAAGAGAGATATAAATGCACCGGAGTTCAATTTTAAGCTCGTATTATAGATATACGTCATTGTATCAGGGGTGGGCGGCAATTGCGTCGTTCGGCAAATTGACCGCCAAATTCGGCATATCAATTGCCGGTTTGTCGATTTGCCGGAAATTTTCAATTCCGGCAATTTGCTGGTTTGCCGATTTGCCGGAAGTTTTAGGGTCATGTTTTTCGGTCAAATCAGTTTTGCCGGAAATTTGGTTATATAAGAGACGGACTGTCTTTTTGAGTTGTTCCCGTTTTTTTACATATTTTCATAGAAATTCATCGAGATAATTTGCCGAAATTTTTCGGCAAATTGCCGTTTTGGCAATTTACCGATTTGCCGGAAATTTCCATTCCGACAATTTGATATGCCAATTCGCCGGAAAAAATCGTTTGCCGCCCACCCCTGAATATAGAGCCCTTTTTAGTCTCATGTCACCTCGATCACGTGAAATGCTGTCAGACAGCAAAAAGACGACCGTTGATGATGATTCAGCAGTTCCAAGAACAACAAATGTCGCTGGAGCAGTCACTTCTACGATTCCTGCTCTCACCTCTGAAAACGTCCCGTTCTAATTCAGCCACCCAAAGACCTTATATGGTGCGGGACGAAAGCCAAAACGGTGCTCCGGAACTTGACGGATCTGGCAGCGTTTCACTTTCACTCAAGAGCTCACTGACTGGAGGTGATAAGTGGCTTGGAGAAGCCGTGGCAAGGAATTGGATTCGCTCGGTTAGCATCCTTTTTTTATTGGAGCGGCGGCGTAAAAATCGTGCCAGAGTTGCGAGAGGGGGCGTGTTTTTTAGTTTTTCTGTTGTTGGTGGGGACTTATTATTATTAGGTTGGTGATTTTATTTTCACTGGTGGAAATCAGCTAATAAAACTAAAAAATAACTTCGGGATATGCAAATAAAAACCCAACTTTAAAAAGCGAACTCCGATCAGCAGTTTGCTCGGCCCACTATTCAACCAATCCAATTGGTTCGTTGAAATTCTTGGGAACTCATTGTTAGAGGATAGAATTCAAACGAAAGATTAGCAAGTTCACTGGTTATTGCTTTCATTAGAATATCATTGCTTATATATATATTTCAATAAAAAAATAGTGTACGTCATCAATGGGCGGAGCCTCTTCCATCGTGGAGACCCATCGTGGTGAGACACGTGGTGGTGAGACCCATCGTGGTGAGACTTCGTGGTGAGACGTGGTGGATTCAGACCCGTAAATAGAGACCTGCGCATCGAGGTGAGACCCCTCCTGGTGAGACCCATCGTGGTGAGACCCATCGAGGAGAGACCCTTCGTGGTGAGACCCATCGTGGTGAGTCCCCCATTAATTTTGGCGTGAAATTCAAATTTTCTAAGATCGATTTGGCTTTTTTTCGTTTAACGAAAAATCTGGAAAGGAAATTCTAGCATTTTTTTAGAATAATCTGATGAGGAAATTTCTTACTTTCCAGCGAAATCTGGAAACTCCAAGGATTTCCTAACATAATCTGGAGACTTCTAAATAAGATCAGGAAATTTCTAGAACTTTTTTATAATCGTCTGAAAACATCTTTCTAGAGTATACTAAAAACTTCTAGAATTTTAAAATTCCGCGAAGATCGAGGAAGAGATTTGCCAAGTTCAATTAATGTGGAGCCAGACGGAGCACGCGCTTTGCGCGCGCGAAACGGCTGGTTTTAGATATTTTGTAGTATTTTTCAAATCTTAAAAGAGCAGAGGTGAAAAAAAAACGAACTGCAATAACAGAAAATCGATGTCGAGAAGGACTGTAAAACCTGGAAATCCAACTCGCGCCAAAATTTAACCAATCGGAAGACTTTCCTGCCTTGGACTTCAATCTCGTGAAACTTGGCAAAGACTAGGTGAACATCAGTCTTTTGCGTAGATGTTCCATTGGGAAGAAATGTTCATCTAGGTCAAGCTCCGGTCACACGGAAGATACATTAATGTTCGACAAGCGAATCACTCACATTGATCTACTCGGCGGGCCTGCGATGAAACCATCGAATTCTTCCCTATAAAAAAGGCAGAAGATTATACAGAATTCCGTATGGTCAGATGTGGATCAATCCCTTAACCGCCGTGTCGAGTATGTCAATGACGATGTGTACCGATTTGCAATTGAAGGAGTGCCCCACGGATTCTCCAACTCGATCAACTGCAATGTGACTGTTATCAGCATTTGGAAGGACGCTGTGCCTTTGAAACAAGCAATCGCCTCAGAGAGGCACTTGGTCTACACTACTTCTTGCTTCTGAAAGCACCCCCTGACGAATGCGACCGATGATCGTCTCACCACGTGGAGCTTGTAGGACGAGCTGGCTACTTTTTGGCACTTGCGGTTGCAGTCAACACGATTGATGCAAAGCTGGCCGAACCTGTATTGCGGATATTGTCCAATCGATTAGCTCCCAGAGACCAAGAGCCGTGGATTCTTGTCAGTATCTGCTCCCTGTGCATTTCGTTGCTCTACTTCATCAAGGAATTGGTTTTTGAGTTCTTGTAAAATGAGAGAATAATTCTCTAATTTACAGAAGAAAGGGACAAAACAATCAGAAGGGGAAGCCAACACTGAGCAACAAATACGTCTACAACAAGTCGGTTGAGTTGACGAAGCAATTAACCGTTCTCCTTCTAGAAGCCAGGAGAGTGTGATGGGACCTGGATAGTTCTTCTCCATTATGAATATGTGAAAAGCATTTGAATTGATCTGGGTTTGGAAATGAAGAATTTTATAATGGATTCTTTCCGAAATCTTCCTTCCTGCCTGCTGTTAACTCTGCGGCTTGATCTGCAAAAAAAGCGGTAATATCTCCCCCAGGAAGACGTCAGCACACTCTTAACCATGCCTTAGTTGAAACGTTTCTCGGTATTCTCCCGCATTTTTCGAAGATCACACCAAAATGGGATACTTTGACAACACGTGCCTGCCATCGCTTCCTGAACGGGGATTTTGTTAGAAAATTCGTGGAAAATAGGAAGAATCATTTCGAGAAAATGGAATTATTGACTCTTTTCTGATTTTCTCAAACAAAAAAAAATTAAAATCGAATTGATTTCTGGCTTACCTTACCTAAATAGAATTGAAATGGAAGAGTTTGCCGAACTAGGCCATTTGTGGCGGCCTGGGGTATATTTGCGGCGAGTTGCGTGTCGTCGCGGCTCGTTGTTGTAAATCTAAATGTGATTCGACCGTGTGGAGTACACGACTTTCACATTCGTTGTGCCGCGGGCGATTGTCAAAGGAGCGCGAAAAATACAATGAGGAAATCGGCCAAAACCCCGTGTATTGATTTTTCGAAAATTTCGGAAAAATCTGCTAATTTTATTCAATATTTACATTTGTCCTAATTTCTTAGAAATGTTCAAAAAATCTGATTTTCTTTTTCCCGATGAATTTTTGTAAAATAGTTGCTATCCGTATTTCTCGAAAAGAATCGATTATTTTTTTCCGGTTTCCTGGTAAGCTAATCACTTCAGAAAAAAGAATTAAGTTAATATATACTTATAAAAGTCGTAAAAGGTTGGAAATATAAAGTATTTAAATCAGAACAGCGATTACTGACTGAAGCATCTCAACTACCAGGCAAGTTCTTCTTATCGAACTCGACAAATGAAACGAAGAGGTCGGAGCTATAATTGTGCCGATCATTTTCCGGGCGCCCGTCTCTTCGAACTCGGATACGGTAGCCTGCCCGACGTATGTGAAATCGGCCATTAGCACTCAATCGGCAAGCGCCGATTGATGCTCCGTGGCCGACGATAGGGCTTCCTGAAAGAAAATCGATAATTTGCGGTGTGTTTTTATTGATTTTTATGTGAAAATTGGCAAATTATTGATTTTTCGGCTAAATCATAAATTACTGATGTTCTAACCCGTTAAAATCAGTAATTTATTGATTTCTTCGGCTAAATCAGGAATTATCGATTTTTCAGTGAAAATCTGAAAATGATTGAACATTTTACAGCTCTGCGAAAATCAGAAATTAGTTTCGCAAAAATTCACCTTCATATTTCTAAATCGCCACGCAGGGTCTTTCCGACACGTGGCACACACGCGTCATCTCCACATCCTTCGCGGGGTAGTGTGTTCTGAAAAAAAAGCCATTCGGTAATTTTTATAGGTCTCGCACCGGATTGCCGCCACCGGTTATCTTCATTTTTCCAACTAAAGCGCCAACACCGGCGCCGGCATCTTCTTATTTTTCCACGTAGCCGGCGCCAGCCGCGCCAAAACTATCTTCAAGCGGCGCCGGGCAGCTTTTTATTTTCCCCATAGCGTGCCAGCGGCGCCGCCGGCATCTTTTTATTTTTCCACGTAGCACGTCGGCGCCGGCAGCCGCGCAAACTATTTTCGCCGCCGCCGGTTTACTTTTCCACGTAGCGCGCCAGCGGCGCCGCCGGCAAGTTTTAATTTTCTTCCACGTAGCGCATAGGCTAGCGCCGCCCCCGGCATCTTTTCATTTTTCCACGTAGCGCGCCAGCGCCGGCAGCCTCGCAAACTATTTCACTGTTCGCCCGCCGGCATCTTTTTATTTTCCACATAGCGTGCCAGCGGCGCCGCCAGCATATTTTTATTTTTCCACGTAGCGCGCTAGCGCCGGCGCCGGAATTCATTCTTTTTTCCACATAGCGTGCCAGCGGCGCCGCCGGCATCTTTTTATTTTTCCACCTAGGGCGCTAGTGCCGGCCGCATTTTCATCTTTTCATGCAGTGACCGCCAGCGCGGCCGCCGGCCTCTTCTCATTATCCATGTCGCGCTAGCGCCGGCGGCAGCGCAAACGATTCTTCGCCGCCCCCGGCGCGTTTTCCTTTATTAATTAGTGCGCCAGCGCCGCCGCCGGCATCTTTTGATTTTTCCGCAGTGCGCCAGCGCGGCAACGGCGCAATTCTAATCTCGGTCTTTTTTGACCGATACCTGAAAACGCCTAGGAATATAGTGGGGCCAAATCTACAAGCGGAAATTTCTCAGCTAGTTTGTCGGTTTCCCAGATTCCAGGAGGCTTATCACAAAGATAAAGTGCCTCACAAAGGCCACCGTCCGCCTTCACTTTCATTCCTCTATCCTCAATAATCGTCGAAGCTGTCTCAATTGTCCGTCGAACGGCGAGGCAAACGTATGCGAGATTGCCATTTTCGAACCCATATTTTGCACTCTTTCGCCTGTTGCCGACCGCGCACGCTGAGCATCGAATTATCCGTCGTGAGACCGTCGGCTCCGTCGAGTAAATTACGCCAATTTCGATTGATATTGTTGTCTCCTCGCTGCAACGCAAAAAATCAATAATTTCTGATTTCCAACGTAAAATCAATAAGTGTTCTGATTTTTGTTGAAAAATCATTACTACCGATTTTAACTGAAAAATCAATAAATGCTGATTTTCCTTTTTTTTGCACGTACAAAAGTCGATAATTTCCAGATTCTCATCGAAAAATCAATAATTTGTGATTTTCGCCAACAAAAAATCAATAATTCAGATTTTTACCGAAAACACAAATTGATAATTTCAGATTTTCACCGAAAAATCAGAAATTATTGACTTTGGATAAAAATCAAAAATTTACTGATTTTCATCTAAAAATCAATAATTTCAACCATTCGCAGAAACATCGGTCATTTTTAATTTTCACCGTAGAATCAATAATTTCTGATTTTCACCAAAAATTATCAAATAATTTTAATTTTTTTTTCGAAAAATCAATATTTTCTAAGTGCTTTTTATCGGAAAATCAATAATTTCCGATTTTCACCAAAAAATCAATAATTTCAGATTTTTTTCGCATAAAAAAGCTCTGTAAATAATTTACGAAGTTGACGAGAAATCAATAATTTGCTGATTTTATTCTCACAGAAAATCAATAAATTTTTTTTGTTTTTCGTTGTTTTTTTTTTCTAAAAATCAGCGTTTTTAATTTCCCCAAAAAATCAGTAATTTTTTAGGGATTTTATTTTTCGAAAAATCATTTCAGATACCGAAAAAATCAATAAATTCAAAAAAAAGTATTTCATTTTTTTGAATTCTTCAAAGTACCGTTCCACGTGTCAGAACAATCCAAATTTTCCGTGGATAAGTTATCGGCATCCTATCGATATCGGTTTTAGCTGAAGAAAAAACTTAAACAATTGGAAAATTGTGTCCTCCTGTCGGACAGGTGCTCGGTGCTCTCCCATCACGGCTTGTCTACAAAAAATGCGGGATTCTTCGTTCTTAACCATACGAAATCAGTTGACTCTGCGTCTCTCTTCCCGCATTTTTTGTAGATCAACGTAGATCAGACCAAAATGAGGAGCACACTGAATGAAGACACCATGATTTTTCGAAACAAAAGAAATTCTCAAAAAGTGACGTCAAGAGGTATATAGGTAAATCGGATACTTGGTATCAAATGACGGAAAAACAAACGAAAGTTGCAAAATTTTTAGATGAAATTAATTAGACTTTGGCGGGAAAAACAGATCAAATTTACATTAAAATACCGGAAAAATAGGGGGAAAAAAGCCTAATTATTGCCTAAAAAATTCAGGATTAAACGGGTTGTACTTTTTCTTCTTTCCACGCTTCTCCTCCGATTCCTCGGCGGCTTTTCGTTTCTGCAGCAGCTCAATTTCCTCGGGATGTAGCAAAGCATGGGCTCTCGCTTTCTCGACTCGTTCCCGGCAGTTTCTAGACGCTTCTCGCATGCTCGCCAGGCCGTCGTTCTCGATCGTATACCTCTTCGAGTTGACGTTCTTCAGAGCTATCACGGTGGCGGTACTGCTTTTTTGGAAGAAAAATTGGGGGGTTTTTTTGTGGTTTGTAGTGGGCACCCTATATGCGCGAAAAAAGAGTCGAATTTTTTTGTAGATCAACGTATGGTGAAGAACGTACTGGCGTCATATAATTTTGGGCGAAATTCCCGCATTTTTGGTAGATCAAACCGTAGTTGAAAATTTTTCGGGAAAAAAAATTACGAATTTCTGGCTTTTCTCAAATTGAAATGGAAGAGTTTTTTCCGAAATTGGCCATTTTGGCTCGGCCATATCTGAGCTAGATTTACGACACGTTGCGTGTCGCTTCGCGGCTCGATTTTAGTTGTAAAACTAAATGTGATGTCCGTGTGGAGTACACGACTTTCCCACGCGTTGTCCAGGCGATTGTCAATGGAGGGCGAAAAATTCAATGAGGAAGGCCTGAACCCCGTGGTAGTCCGATGCACAAAACTGATTTTGTTTTTGAATTCTTGGGATTGAAGAAATTTTGCCGATAAAGCCGATAACTCAAAAAATTCTAAAAAATTTGGATAATGTCTGGAGGAAAAACCCCAATGCTGAAAATTTCGAATAATTTAAAATTTTTGCGCATGGCCGAAAAGAATAAAACTCGGCCAATTCTTTGGCGGCCATGATGCAAGACACCATATTTGACGCACGCAAAAAAAGGTGTTTTTGGATGTTATTTTCTTTTTCCGCCAGAATCTTTAATAATGGTATCTATTCCAGTGACAAAAAATCATAACCTGTTGCAAAAAACGGATGTTATTTTTTTCGAAAAATTCAATTTTGCGCGTCAGATGTGATGCTTTAAGCTCTGTGGCCGCCCAAAAAGAGAACACTCGGCCCACCAATTTTTCGATGACTCCATTGACAATAGCCTGCTGGACACCGGGTGGAAAAGTTTCGTGTACTCCCATGGGGCACGGACAAATACATTTAGTTACCATTTACAACTAAACGAGCCGCGACGCGACACGCAACGCGCCGTAAATCTACCGTGGCCAGATGTGGTATGGCCTGGCCTAGTTCGGCAGGAAGGTTTCTCTTCCATTTCAATTTATGAGGGAGGCCAGAAATCCGTGGCCGAAAAAGAGAAAACTCGGTCTCCATCCGATTTTTTTTTCTGACGGCCATGACAAGTTTGCGCGACAATAATACACTTCATCATATTTGGCAAAAAATTTTTTAAAGTTTTTTCGAATTTTTTTGATTTCCGAGCAGAAAAAAAAATTGTCTGAGAAATTTATGTGGCCGCGGTAAACTTCGGCCACCGATTTTCGAAGATTTTGACCGTGTTTGAGGGAAAAAGCAATTTGACGCGCAAATTTTCAAAAAAAAAAAAGCCCAAAACACTTTTCTTCTTCTTCTTGTCTTTTGTTAGATGCCGTTTCTGCCTTTTCTTCACTATCACTATCCTCTCGTTTCCGCCTTCCCCTCCTCTTCCAGCTTCCGCTCCGCTCAAACACGGCAGAGCATCGCGCGCTTTTCGTCGATCAAGTGTCGGCGGCTTTACGCAGCGGAGCTCCTCGTACCACTCGTTTTTGTTGTTTAAATCGTATTATCCGCGAAATACACCTGAATTCACATTTACGTCGACTCCCATTCCTTCTTCTCGGCCGCTTTTTCCGCTTCGTAGCCGCGGTTTCCGGATCCATAGTTTTTTCGTTCTTCACGTTCGAGATCCTACAAAATATCATTTTTTTTGGAGAGAAATTTAGTTTTTTTTTGGAGAAAATTATCGATTTTCTGGAAAAAATTATCGATTTTTCGGGGAAAGATTAATTACGATTATTTTAAAAGAAAATTATCGATTTATATTGGGAAAAAAATCACTGATTTTCTGGAAAAAATTATCGTTTTTTGTCGGAGAAAGAATATTAAATTTTTTGCAGAAAATTATCGTTTGTTTTTTTGAAAAAAATTTCCGATTTTTCAGAGAAAACTTTTTTATAAAATTATGGATTTTTAAATATAAAATTAACGGTTTTTAGACGCTGGAGTCTTCAAAATTGCGAGATCGATTTTTTTCTGGAGAAAAACATATTGTTTTTTTTTGGAGAAAAATTTCGATTTTTTTGAAGACATTTATCTTGGTGATTGTTGATAAAATTATCGATTCTTCGGGGACAAGTATAGCTTTTTTTGGATGAAATTATCGATTTTTTGGGAGAAAAAATACCGATTTTTTCCGTTTGGATCAAATTACCGTTTGAAAAACAAGTATCACAATTTTTTGAAGAAAATTGTCAATTTTTTTGGTAATAAATATAGTTGTTTTGGATAAAACGAGATTTTTCAGCTAAAAATATAGATTTTTGCTTTTAGATAAAATTTTGATTTAAAAAGAAAATTATCGATTTTATGGGTAAAAAATAACGTTTTTTGGATAAAATTATGGGTTGATTTCTTCGGGGTTCGTATAAATATTGATTCTGTCGGGGAAAATATTTTTTGGATAAAATTATCGATTTTTTGGAAAAAATTATGGGTTTTTTTTGAAGAATGATTTTATTGGTGAACAATATCGAATTTTTTCGGGAAAATATCGATTTTTCGGAGAAAATTTCTCATCGATTTTTAGAAATTATCGATTTTAAATTGGGTAACAATCTCGATTTTTTGAAGCAATTCTGAGCCAAATTTTGAATTTTCGAGCGGCAATTTTTGCACAAAGCATTATAGGTTTGACGCACAAAATTCGAATTCTTCAGAATTAGTTTCACAAAAAATTCTATCACCTAAAACTAGTTCACATGTCCCGTTTCATCTGAAACGCTGACATTTTTTGGCTTCTCCACGCTGAGCTCGAACCAGCTCCTCCACTGAACATCGTCTCCATTCGTTCATCGGCTCGGGCTCTCGACTGCATAGCCTCAGGCGCCGCGCCTCGTTTTCCGCCTGAATTTGCCTGTCGAGCAGACGCTGCGCATCTTCGGCGGCTTTTCGCTCGTCTCGGCGAACCCGTTGTTGGATTTTGTCCGAACGTGCCATGATTTGCCAAATGATGGAGAATGTATCATTCATCTGGAAGCGGAAATTATAGAGCAAACCAGTTGATAATTGTGCTCGAAATTTGGGGAAGAAGCGCAACCAAAAAATCAATAATTACGTCCAAAAATCTATTTTATTCAGAAAAACCAGAAAGCGATTTTTTTTCCAAAAATAAATAATTTTCGTGCAAAAATCGATAATTTAGACCGCTTCTAAAAGTCTCAATTTTTCCAACAAAGAAAACAATCTCGAAAAACCGATGTTTACAGAAAAAACAAAAAGCAAAAATTCATAAAAATTAAAAAATTAAAAAAAAATCAATAATTTTTCTAAAAGCGATTTCTTTTTCTAAAAATCCTTGCGTTTAATTTTCTTCTGAAATCGATATTTTCCGTTGCTTTTGGTTTCGTGAAAAAAATCGTCTATTGAACATTTTGCTAAATTTCGAAAAAAAATCTTGAACGATGCACCATGATTTTGAAAATTCTGCTCTGGATCAATTTTTCGAGAAAATCGATTTTTGGAAACTATCATACAAAAATCGACTGCTAGTTGTGCTCGAGATTTGGCTCTGAGGAAAAATCAAAAATTTTCTTCTAAAAATCGATTTTTTATCCAAAAAATCAATAATTTCGTCGGACAAACCGATGTTTTCAGAATAATCAAAAAAAAAATTAAAAAATTAAAAAAAAAATTTCAATACTTTCTAAAATTTTGCGATATCTTTTCTAAAACTATTTAATTTTCTTCTAAAATCGATATTTTTGATTTTTTCGTGAAAAAAATCGTCAATGTTATTGAAATTTTTGCTTAATTTCGAAAAAAAATCTTGAAACTTCGATGCACCATGATTTTGAAAATTCTGCTCCGGAACAATTTTTCGAGAAAAATTTATCGATTTTTGGAAACTATCATACAAAAATCGACGGTAATTGTGTTCGAAATTTGGGAAGGAGGAAAAATCAATAATTTTTTTCTAAAAATCGATTTTTTTTCTACGCGAATCAATAATTTCGTAACCGATGTTTTCAGAATAATCAAAACAAATTTCAAAAATAATAAAAAATCAATAATTTTTTCTAAAATTTTGCAATTTTTTTCTAAAAATCGTTTAATCTTCCTCTAAAATCGATATTTTTCCGGATTTTTTCGTGAAAAAAATCATCAACTTTATTGAAATTTTGTCATACTAAATTTCGAAAAAAAATCTTGAAATTTTGATGCACCATGATTTTCAAAATTCTGCTCCGGACCAATTTTTCGAGAAAAATTATCGATTTTTGGAAATTAGCATACAAAATTCGATGTGCTCGAAATTTGGCTCTGGAAGGAGGAAAAATTAATAATTTTCTAAAAACCGATTTTTTTTCCAAAAAATCAATAATCACGTTCGGCTAATGGAAAACCGATGTCCTTTCAATCAAAACAATCTCAAAAATAATAAAATCACTAAATCAATAATTTTGTCTAAAATTTTGCAATTCTTTTTTCTATAAATCGTATTTTTCCGATTTTTTTCGTGAAAATAACTCGTCTTTTATTGAAAATTTTGCTTTTCGATAAAACGATGATTTTGATTTCGATGCACCATGATTTCGAAAATTCTGCTCCTGAGCAATTTTTCTTTAAGAAAATTACGATTTGTGGAAATCATCACACAAAAACCGATAATTTTGTGAAAAAATTCGGTTTCGCACCATGATTTCGAAAATTCTCAGAATTTTAGAAAATTTATCGATTTTGTGTAGAAATTCGAATTCCAGTGGAAAAATTTTCTTTGTATTTCTCAAAAAATGTTTGATTTAAAAAAAATCGATTTTATGATCTGAAATTCAGGCATTTTTGTAGGGCAAAGTAAAATGGCAAAATCGATGATTTCTCTGATGAGAATGGGAATTTTTGTCAAGAAAAATATAAAAAATTCTTAAACAATTAAAGTGTTGTCAAAAAATTGAAATTTTGCGGAAAAAAAATATATTTACAGATGAATTTTTTAGAAAAATTCTACAAAAAGAGGTTCCATCTAATATTATTTTGTCGCATTGGGAGTTTATATCACATAATTTTTTTTTGTTTCGGTTGCCGTGGAGAATGGGGGTTGCAAATACCAATATCACATTTTTCAGAGGAAAATCACAACAAATATAAGGAAAATTTAAAAAAGGCGCGGGGGGAAATTCACCAGATTATCGATATTTATGGATAATTTCCACGATTATTTTTATAGCAAAATTGATCCGGAGCAGACTTGGGATAAAGCAAATGTTGGAGGGGGAAAATGAACAAATTGATAAATTATAATATATTCGGGGCAAAAAATGGGAAATAATTAAATTGTCGGAACATATAAATGATTAATTGATTGAGGCCAATGGGATTGGTTTCATGTGAGCCAACGCTTCATTACAGACCACTTCCTACCGATGACGTAGCGGCCATGAGAATGCTCGACACGAGCAAGACGGTAGGTTCTAGAGGCGTTTATCTGGAAATTTTGTGAAAAAATGAAGAAAACAAGCTTTCTTCGCTGAAAATTCCAAGATTTTCGGTCGTTTTTTTTTTGCTAATTTTTTTTAAATTCGCCTTGAATTAAATTTCCAGATGTTCAGTAACACGTTTTTTTCTCCTTCAAAAATCGGTTTTTCAATTAATCAAATTCAGAGTATTAATAATTATTTTCCTCCACCAGAATTTGAATATTTTATCCACATTCTGAAACCGGCTCACAGAGCGGCTATTACTACGTGGCCTAGAAAAATCAAACGAACTCCGCCAATGATTTATCCCGTGGCGATTTTTGTGGGATATTTCGGAAACTTGACGAGAATGTTCTCGAATGGTCGGGGGTGCTACAGTTCCACCGTGGCGATTTTTGAGAATATGTTCCGTAGTTATGAAGGTGGCCGAGGGTTGTTTTCTTATTTTACGGCCACGTAATAAAAACCGATCTGTGGGCTCCTGAGCAGAATATCGAAACATATCATGGTGCATCGAAAATTTCAAAATTATCGATTTTTTTGTTGTAGCAAAATTTTCAATAAAATAAGAAATCATGGTGCATGGACAAACCAATTTTTTCCTTTTTTTCGAATTTAAAATAAAATTTAAAAAACAGTAAAATTCTTGAATTTTACTTTTTAAAAATATTTTTTTCAAATTCTGGCAGTTTTAAAATAATAAAAAACGTTTTTTTTTCCATTTTTTTCAATAAAGTTTTTTTATGCCATGATTAGTACTACTAATGTAAAATTTACAGGGTTTTCACAGATTTTCAATTTTGTTGATTGGCTTATTCGTTCTTCAAAAATTCTAAATTTTCAGGTTTTCTTTTCCATTCGCCTTTAATTTTTGGGAAAAAACAATGTTTTTAATTAATTTTTCAGAAGGACTTAAAAAATTGTGACAACTAAAATTGTTCAATTTTTTCCGCAAAAATAATTTTTCGGAAATCCGCGTTCAAATGTCCTACAAAAAACCCCTTACCACAGTAAGCCTAACCAACTGTGAGAGCTCTCTGTTCATCGACTAGGGCTCCGTCGAAAAGCCGCCCAAACTCTAGAGCCGACGCCGTATCGACGCGCACTCGAACCATCTGAAAAACCAAAAATGGAAGAGCTTCTAATTTTTCGTCCAAGGCAGGCCATTTGATCTACGTAGATCTAGAAAAATTGCGAGAAAGAAGAGACGCAGAGTTCTCAACGCTTTCGCATGATTAGGAGTGTGTTGACGTCACATTCGCAAAAAATTCCCGCATTTTTTGTAGATCAAACTGTAATGGGATGGGACCACGAGCAGTGTTAGGCTGTACCATTACGGTTTGAGCTACAAAAAATGCCGGAATTTCTTGCAGAGGTCAACACACTCCTAATCATGCGAAATCAGTTGAGAACTCTGCGCCTCTTTTTCTTGTCCTGCATTTTTGTAGATCAATGTATATAAGCCTCTCTCTCTCTCACCTGAAGTATCACCGCTTGCTCCAACACAATCAGAACATCACAAAACTTGCTGGCAATCGTTTCGCGGGTGTACACTTTCCGTGTGTTCTCACCACACCACATGCCCTCATCGTTTCCGATATGCTTCCCTTGTGGCTGCTGCACAGCCGTTGAGTCGTGCTCACATGGAATATCACCTCAGCCTCGGCGTCTGCAAAGTACGGAGCCCGTGTCTCTACGGGCAGCCACCTGTGTAATCATCGTGTCCTCGACCCACTTTGACCTCCCATCCGAGCTCCGAAGCTATTGCGCGGGGGCGGATGCGGTGGTGTTGGACAGGATCGATGCTCGATCCTCCGGCGATTGTCCTAATAGATCACATCGACTTTGTGGACTTCACGAGAACAAGTCTGATCTAAATGCCAAGTCACGGGGAAATTCTGCCGTGAACCTGAGACACAAGTGGGACAGGAATCCCCGGGAAGCCGACAGCGATCTCCATTCGACTGTCGCGTTCGGAGTGAACGCTGGCAAGTGATCGTGGGGCGCCGACGATGTGGAGGCTGTGGCTGCCGTCTAGACGTCTCAATCATCGATGTAAACTGTGCGGCACCAAGGCGGGCTCGTGACGGGGGATAGGTCCGGTATATCATCCGAACGGATCATCCATCGCGGATCCCCTGGCTTTCCGGACCGGGACGTTTTCCCTTGAGAGCCTCTTTGCGTAGCCAATTGGTCACATTGGTGGCAGGCTTGCGGACATCCGGTTCTAGATCCAGATATGCCGGCCAACTAACGTTCGGGAAGTGATTTCGCAGGGGAATTTGGCGTAGAAATCCTTTTAGACGGGACACCGAGATTAATCGCCGATTGCCTATTAATATACACGGTTTTATGCTCTCCTTGTAGTGGCGGTGCTCCTGCAGAGCTCCATATCTGAACCTCAAAACCTCGCACCGGATTCTGACCACCGAGCGTGACAAGCTCTCCATGGGAGCACCATATCCTATCGGCCAAGATACCACGAATGACGATTGGCATTTGAGGTTTTGGCCATTGATGGGCATACAAGGCTTCACCATCTGCCACTCGATCTCGGTTCTCGTACGCTCATCGCGTAGGTGATGGAGCGAGGCGGCTCACGGAGCAGCGCCTGGAGCAGTGCTCGAGAACTGGGCTAGCGAGGCGATCGGCAGAAGAGCGGAATGGGCCGCATAGCGGACTCGATGGGTTTCGATGGTTAACGCGGTGAGCACCAAGACGAGTTGGGACGTTTTGCACGTTGAGGATGGCTAGCGAGTTACCACGATTACTAGGGCATTCTGCGATACGTCTGCATTGACAAGCTGATCGACAAGGATTGGCTCGGCTCCATGATACGATGAATCTAGCATTGAGAAACTTCAACGAGTGCGAGGACACCTTCGTGTCCTTCGAGCTCTTCGCCGCCTGCAACATCTTCGGCAAATGCTCCAGAGCTCGCGTACGGAGCAACATGAAGTGATACTTCGTGTGCCAGAGAGCCCACAGATCGCCAGAGCCACTAGTTGCACCTTGGATAGGAGTGCATAAGACGGATGAAGCAGAAAAGAATGTTGTCCGAGAGCAGTGGCGGTGGCGGACGGTTCCTTGATTCGTCGAGAATTGCACTTAGAGCCGGAACATAGCGGGGCAGCAGGATTGGGGGTACGGTAACGAGGGTGCGGCACGCGAGCCTTACGAGTGGGCCAGTGGGTGCAGCTATACCGGGAAAGCAATGTAATTTTTTTTTCGGGCTTTTTTTCAAATCGAATTTTCACTTTTTCTAAATTTTTTTGTAAATTTTCTAAAAATAATTGTTCGATTTCAGAGTACCTCATTTCTCCGTGCGTGATCTACGTTGATCACGTGACAAATAATGCGGGACTGATTGTCCATGGTTAAGAACATGCCGACGTCCTATTTTTTGGGCAAAAATTCCCGCATTTTTTGTAAGATCACCACAAACAGTAATGACAGCCTCACGTCGTGCCAGAAAGTCCCATTTCGTGCTTCGATTACGCTGATCTCAAAAAATGAGTGTCTGATTGTGCATGATTAAGAATGTGCTGACGTCACATTTCGTTTGGAAATTCCCCCATTATTTGTAGGTCACACCGTAATGGGACAGCCTGACACCACGTGATCTTCAAATTCCGGCCAGCGTGAAACCCAAAAGCAAGATCTCAATCGTCAATGACATGACGCAATCGATTGCCACGTGGGCACTCGAGTTGGTCTACGGATCCACGAGTGAGATGCCACGACGCCATGAAACGCCAATTCGTCGCCCGACAAAGACTGAAAAAGGGAAAAAGGGTGTGATATGCGCACGAGCTGTAAGAAAGGCTAATTAGTTGTCCACCTAAACAGGATAAAATGCTGAAAAGGCATTTTTCAGGGTCTATTTTCACAATGAGTTTGGGTATATTGGAGAGTTTTCCATAGATAATGACTGCGCAACTAATTTTGACGCGCATAATATCACGTAGCGAAGACTACAGTATTTAAATTACTACTGTAGCGCGCTGTGTGTCGATATACGGAATTAATTAAAATATTAATTGATAAAACAGAAACTATGATCAAAGAGACCCGTAAATGGACACAATCGCTACAAATTCAAAAAGTACTGTAGTTTTCGCCTACGAGATATTTTGCGCGTCAAGTATGCTAAGAAAATATGCAGTTGTGGTAGCCTTGTGAATTTTTAGAAGGTTTTTTGAAAAATAACTCGCCACTATTAAAAAAAATATATATTGAGGCTTTTCAAAGGGTTAAAGTAATTTTATACGTTTTTAAAATCGTTTTTTTTTAAAACTAAATTTTGAGCGTTTTTAGGACAATTTTCGTAACTTTTACGCTTTTTTTATGGCCATATTGTGTAGTTTTTTACACTCTGATATTCCAGAAATCGTCAGAAAAAGCACTTAAAACGGGCTAGAAAAACGGGGTTTTGGCTTGCTGCGAAACTTTTTTTTTTGAACCAAACTTACCGCGCAAAAATATATTGTCATTCAAGTAATGTTGCAAAATGTATAAAAAACAGGTTTTTAATGTTTACGATTTTAATACAGTTGTGACGTATTTTTTCTATTTCAATTTTTGCAAAATAAGAAAAAATATGACTGGAAAAAAGTTGGAAAGTTTTTAAAACACATTTTATACAGGAGCGGTCATTACGCTCTAAGATTTGCTGGCATAAGCGAGAATGGTCTTTGACACTACATATATAATATTAAGTCTCCAAATAAGTCCGGGTCTAAAATCATAAATTTGTTCGCTGTGTATCGATGTTTATGAAATTGTGGGAATTTGTGTTATCAACCCTGATCTTTCATTTGATGGGCAAGAGTCACAAAATTTTTTGGCCGTCGGAAGTGCCCCGCCGGTACTCGCAGCCAATTTTTTCAGACATGTTTCAGATCCCGCTTCTTTTCAGTTTTCAACTGAGGATGGTGTGCGGAAGGTCTATTGCTTAGTTTAGTACACAATGTAAGAAAACAAAAAAGTTTGGAAAAAAATCCGTCCAACAGAAATAAAATATGTTTTTTGTCGCTCGTCAAAAAATCTACAAAATTTTGTCGAAAATTATTTGAATTTTTACACCCAATAAAAATGATGTAACCGTGTGCAAACTAATTTTAATCACACAAAACGACTTATGAAATTTGGATCGAGGAATACTCCATTCTAAAACTCGATAATAGTTCGAAAAAGCTGTGTTTTTTGTTATTTTTTTTAGTGTGATGCACCAAAGTGAAATTTTTTGTATGTGAAAAAATAGTTTGCATGGTTACATCATTTATAAAAAATCGAGAATTTTCGAAATCTGATTTGTTGAAGATTTTTTGACAACCGACAAAAATAATTTTCTTTGGACGGATTTTTTTCCAGACTTGTTTGTTTTCTTACATTGTGTACTAAACTAAGCACACGCACACAAAGCTCGATTGAAAACTGAAAAGAAGCGAGATCTGGAAAATGACTGAAAACTGGCTCCGAGTTAGGGCGCTTCGGACGGCCAAAAAATTGTGACTATTGTCAAATGAAAGATCATGTGGTTGAACATAAATTCCCAAAGTTTCATAAGAATCGATACACAGCGAACAAATGCTGTTATGATTTTTGACCCGGATCCTATTTGGAGACCTAATATATATACATAAAGTATACCTACCGTAACCGCAATCGTAATATCATCACTGTCATGAAAAACGTTATCCTCTGCAATTGTATTCGACGAGGACATATCTCCAGTCTCTGACAATCATTTACTCGGGTCTTCCATCATTGCCGATTCGAGAATTGCCTGTCGTCGACTGTTCTGTGAGAATCCGGTTCTGTCGCTTTTCGGAGAGCTTCTTCACAGAATATGTCGATATGGGCGAGATGGAGGATTAATGCTTGCGTTCCACTGTTCACAATCTGAAGACGTTTTATTTTTTTGATTTTGGCTGGAATAAAGCTATGCTTTTGTTGAAATTTCAGTTTAAAAACATAAGGTTTTTGAACTGAAAATTGGGATCCGGAAAGAATTAGAAAAAAATTTGTTTTTTCTCTAAAACTGCTGTATCCATTTTATTCAATTTTTTAAGATTTTCACAAAACATAAGAATTTTTGTAATTTTTTTTCCAAATTTTTTGAATTTTCAGCAAGAACTGGACAAAAAAGGCACTAGTTTTACTAAAATTGGCAGCATTTAGGAAGCGGTTTCTGAAAAAAACAATTAATTTTCATTATTATTGTCATATGATTACAGGAACACACTATTCTGGACGTAGTATGCGATTACACAACATATTTGACGCGCAGAATATCTCGTAGCTTACAGTAATTCTTTAAAAATGACTACGTAGCGATTGTGTCGATTTGCGGGCACGATTTTTTGATATGAATTTTAATCATATTTTGAGCAAAAAATGGCTCAAAAAACAAGCCCGTAAATCCACACAATCGCTAACATGGTAATTTAAAGAATTACTGTAGTTTTCGCCGAGATATTTAGTGCGTCAAATATGTAATACGCATTCTCAGAATTTTTTGACTTTTCCTATAAAAAAAAATCGTGATCAAAAAAAATTTTTAATTGTATTTTAGGATGAAATTACGATTTTATTCGTTCTCTATAAATTTTGAGCAAATATATTTCAAAAAAAAAAAAAATTCTTTCTATATTTAATTTTTTTTTCGAGTCGAGCTTTTTTTTCTATCTTCTGTACAAAAGCAATTTAAAAAAAAGGAAAAAAGATTAAATCTAGAGTTCTAATTTTCCTCCGGGTTCTGGCCATCCTCATAAACAGAATGGAAGAGTTTTTGCCGAACTAGGCCATTTTGCAAACTCTTCCATTTCAATTTATGAGGAAGGCCAGAGCCTCGTGGAAAATTAGAAATTAGAGTTTCGAAAAATCTTAAAATTTTGCCCGTAAATTTCTTATTAGTGTGTTTTGTACAGGAGATTGAGAAAAAAATCGGCAATTGTATACAATTTAATTTTAAAAACTTATATAGTTAAACATAAATTCAATGATCTAACTGGAAAAAAATGTTTACTTTGAAAAGTTAAAAAAAATGACAAAAATGTAAACTCAAAAATTGAATAAAATGCGGCAATTTCATAAAATAGCTTTTTTCCATAGTTTCTGTCAATTTTCGGCTAAGATTAATTTTTTCTCATCAAAATTTACGATTTTCATACTCTCTTACCGAAGCCCATTGACATCGGTATCCAAACACCCTTCTTCATGACGTCATGATACACCTCATCCCACACCTCATCGTCAATTCCGAGTATGCGTCTGACGCAGGATAGCCTTAATCACGACTGGGATATTCGAGATGAGTGTCGACGTAAAAGCAGCCGACACATTCTCGGAAAACGCGTCCGATTGGCAGACAGATTTTCGAGGCCCATGTGCTTAAAGTGTCGCGCCCTTTCTGAGCCGGAGAATTTTTAGGGAAGCGGTTTAGTGTTTTGAATTCGATGCGAAACCAGCTGCTTGCACGATGTTAGAATCGCAAATGCTATGGAGATAGCCGAGGAGTGACTGGAAAATTTTTTCTTAATTTTTAAATGGCCGATTTTGGGAGGGTTAGTCGAAAAATTTAAAACTAGGATCTATGAAGTTTTTGTCACACGGCAACTTCTGGTTTTTGGAATTTCGCCACTTTTTAACAACCCTGGCAATGCGTGCAAATTTTTGGAAAACCGGCAATTTATGGTGACCTTTCGGAATTTTGCTAATATGAAAACCGGCAATTTGCCGCTTTGCAAATCTTAGGAAAACCGGCAATTTGTGGTTTTTGGAACTTGGCCACTTTTTATCAAGGACCTACAAATTGCTTGCAAATTTTTGGAAAACCGGCAATTTCTGGTTTTTTTTTGGAATTTTTCTAACATTTATAAACCGGCAATTTGCCGATTTGCAAATTTGTGGCAAACCGGCAATTTGTGGTTAAATTCGGCTTTTGGAATTTTTCTAAAATTTTAATGAACCGGCAATTTGGGTTTGCAAATTTTTGGTAAACGGGCAATTTTTGATTTGGAATTTTGCTAAAATTTTTAAAAACCGGACAATTTGCAAAATTTTGGAACAGTAAACCGGCAATTTGTGGTTTTTGGACTTTTGCCACTTTTTATAAACCGACAAAGTCATTTGCCGATTTTCAAATAGGCCAATTGCAGGTTAACCTAAAAAAACATTCCAAAAAAACCAGAAATTGCCGGTTTTCCAAAAATTTGAATATCGGCAAATTGGTAGGTTTATAAAAAATGGCAAAATTCCAAAACCGAACCACAAAATGCCGGTGTTCCAACTCTTTCAACGAGAGTATCCAATTTTTTAAATAGAAAAATTGCCGTATTCCATACCGTTCTCCACACATTTGCCGATTTTCAAATTTTTGGAAAACCGGCAATTTTTGATTTTTGGAAGTCTGTAAAAATTTTTTATAGCGGTTAGTGGTCTATGGATGTCTGTCACCTTTTATCTAAACTTCCACTTGCCGGTTTCAAATTTTTGGAAAACAATCTTTGTAGATTGTTCAAGTCTGCTAACTGGCAAACTGGGAAAATGCCTTAGTTTGGAAGTTTAAGGTAAATTCTCAGACACCGGAATTTTGACATTTTTCAAACTTCCAAAAACCACAAATTGCCGGTTCGCCAAAAAATTGCAAAGCGGCAAATTGCCGGTTCTTAAAAATTTTTGAAAAATTCCAGAAAAACAAGAATTGGCGGTTTGCCAAATTTGCGAAATTCCTACAACTGGAAATTGACGGTTTTCAAAAAAAAACAAAGAAGGGAAATCGGACCAAATTACAGACGCTTACATAAAGTGGCAAAGTTGCAAAATCCAGAAATGATCTTGCCGGTGTGTCAAACTTGCGAACACATTAAAATACCACAAATCAAATTGCCGGTTCCGAAAAGGTGCAAATCGGCAAATTGCCGGTTTTTGAAATGCAAAACTCCCAAAATTTACAGAAAAAATTCCAATAATCAAAAATCCGAATTATTGTTCCACAATCTTCGGAAAAATTATTACAAACACAATCAATTTTCCAACTTTTCATCAAGCGTATTAGCGAAATACAATCGCAAAAATTTCTCGTAATTTATTTTTGATCTACCACTTGTCGTTGACTAGCCTCCGCCCCTCATCTTGTTGCTGTTGTTATAGTTGGTGGCTGTCTAGTTGAAGGAAGGGGCGGAGCCTATTCAACGAGGTAGATCAAAAATAAATTATGAGAAATTTGTGCGATTGTATTTTTTTTGTTCGATAAAATACCCCAATTTTTTAATGGAATAACAATTCCCTACCGTACTACATTGAGCCAAATACGGACTGTGAAGCCCAACAAGATATTCGAGAGCAACAGAATAGCGAGCACGTTCAATCGATATTTCTCCAGACGCTACGAATGGTGGAATTTCGTACTGGAAAAGCCATGCGGAGAGCACATTTACCACTATATGAGTGACATTTGAGCAAATGCCAAGGGGAGTCCTATTTCATTGCTTCACGCATTAGTGTGAATGCTACATTTGTGCCTGGAAAAGGACAAATAAAACTATTTTATTAAATGTAAGTAATTAATTTATTTTTTGAAATCTCTTTAAATGCGGTGTAGTCGAATATTGTTTCAATTGCTTACCCTCAAAATTGTCTGAAAACACCGAATTTCATAATGAACTTCTTGAAAACTTCTCAGAAAAATCTTAGTTATGACGCCTCAAAAAATGAAAATTGGTTAAAATGTGAAATTTGACCTACTTGCCAAGCGGCTGCAAACTATCCAGCTTTTTTTTGAAATCAATGTCAAGTTTTGAGTATTCAATTTAATTATCCGTTTTCAACTCGATTCAGGGGTATTTTAAAGTCGCTATAAACGAAGAGTTTTTTAAAAATTATTTACCAAATCCTTCTACCATCGATTTAAAAATACCTAAATTTAGTTCAAAACGCAAAATAATTAAATTGAATACCCAAAACTTGACCGTGATTTCAAAAGAAACTTAGTTTCCAGCCACTTGACAAGTTGGCAAATTTCAAATTTTAACTTTAGGCAATTTTTTAGAGCGGTCATAACTTTTTTTTTTGGAGAATTTTTCAGGAAGTTTCATTATGAAATTCGGGTGTTTCGATCAGATAATTTTTAGTATAATAAAGCAATAAAAAAAATTCTACACCAACTTCAATCGAAAATGTAAACAATTTTGTTTTGAAGGCGGTTTTCTTTTACTTTTCTAAAAAGAAATATTCAATTTTACGATTTTTTGCGTAAAAAAACACGGTCAAATTTTTGTTAAATTCGAAAAGATTGGCGTGTCCATTACGGTTTGACCTACAAAGAATGCGTGATTTTTTAGCCAAGTGTGACGTCAGACACATTCTGCGTCTCTTCTCCCTCATTCTTTGTAGTACGTAGATCAAGCCGAAACGGGAGAGCCTGACACCACGCGCGTGTGCGCCTGTAAAGTGAGTACTGTAATTTCAAAAAATCCACAACATCCAGAGTTTGAAACTACAGTACTACTATTTAAAGGCCACACACTTTTTCGAAACAACGATAAATTGTGGTGTTGAGACCGTATTTAGGGCTCAAAAAAAAAATAATTATCGTTAGAATATGGTTCGGGAAAGTTCCTATGCAGTTTCACTGAAAATTTGAATTTCCCGCCAAATAACGAATCTTCATCCGAAAAATTTGAATGCCAAACAATTTTTTTAAATCATAAATTTGAATTTCCCGCCATAATCGTATTTCTCAGAAAATTTGGATTTTCCATGCCAAAAATAAAAAAAAAAATTTTGGCGCGGCGAAAATTCAAATTTTCTGAAAAAATAATATTTCGGCGGGAAATGCAAATTTTCAGAGAAATTTTTTGGCGCAATTTTTCCTCGAAGGAATTTTCTTGATGTGTAAATTTCCAAAAATTTCAACGAACCCAAATCGCATTTTTCTTATTTTTTCCCCAAAATTTTCAAAGTTTCTCGTACAACGGAATTTTATGCGACGAAAAAAGCGCATTTCGATACAAAATCATCGATGCATGTGTAGTTTGTAGTGTTGGTTGTCCAGCCGTTGGGTGAGTTGCCGTTGCATATTATTTCCATAGAATTAGGCAATATCTTGCAATTACCACCGGCTGTATTCACCAATGGTTCCCTACCATTCTCATCGGCTGCTTCCCAGCCACCGAACGACTCCGTTCGTATCCAGATTGAAGCATTCGCCCATGTGTAGCCACTTTATTACTCTGAAAATTGAAGAGTTTTATAGGCTCCTCTTACATCGGACATTGAGGTGATTTTTCGAATTCTTTAAAACAAAGATTTCCTGAAATTGAGCTTTTGGAAAATTTTAAAATTAGATCAAAATTTCAAAATCAAAAAAAAAAAAACAAGCGTTTGTACAAAATTTAAAGTGGAGAATTTTTTTTAGATTTCAAATTTTTTAAACATTTCTGAGTGCAGAGTCGCAAATCTCAGGCCAATCGGCTTCGCCGAAATTGAAAATTTCTCATATATCGGAAATTGCCGAAAATGAAAAACTCCGGCAAGTCGGCATATTGCCGGAATTGAAAATTCCTTACAAATCGGCAATTTGCCGGAATTGAGAAAATATCCGGCAAATCGGCAATTTGCCGGAGTTGAAAACTTCCGCCAAATCGGGAATTTTTGCCGAAATTGAAAATTTCGTATAACTCGCCGATTTGCCGGAGTTGAAAAATTCTGGCTAATTTGAAAATCGCCAATTTGGTTGGCCAAAGTTGAAAAACCGGGCAAGCCAATTTGCAGATTTTTCGAAATTTGACCGGCAATTCCTGTCGCGGACACCTTTTTTCCGAGAAGAATTAACTTTCCATTTCTCATTGAAAAAGTCAGTAATTTGCCGGACTTGACAAATTTCCGGCAACTGGACATTATGCTGAAAATGAAACATTCTGGTAAATCGGCAAACTGCCGAAAATGAAAAATTAAATCGGCAATTTGCCGAAGTTGATAATTTCCGCCAGATACAGGGAATTTGCCGAAACTGAAAATTATAAATCGCCGATTTGCCGGAGTTGAAAGATTATGGCAAATTTGCAAATCGGCAATTTGCCAAAGTTGACAAATTCCGCAAATCGCCAACTTTCTGCCTGTTGTGTATATTATTTTCACGAGTAAAAATCGTAATTAATTTAAATTAAATTTGCTTTTCGACCGAAATTTGCCTACCGGCAATTCCTGTCCTTTTTGCCGAGAAGAATTTAAATTTCCAAAAAAATCTTTAATTTGCCGGAGTTGTTTCTGGCAAATTTGCAAATCGGTGTCATACTTTGCCGGAGTTGAAAAATTCTGGAAACCGGCAACCCGGCAAACCGCCAAGTTGCATTTTTCGAGCGAAATTTTTTTTTCCGGTCGCCCCCTTTTTCCCTGAGAACAGTTAAATTTCCAAAATTCTCTAAAAACCACAAACCTTTTCTCAAAAATTCGCACACTTCACTCCTGTCGCTTCCCCTCATCATTCCACTCAATCCGCACATTTTCTCGAGTACAGCACTCCAAAAACTTGTCCAAATAAACTTGGAGCTTTTGAGCCCGTTCTTTCGAAGTCTGACGCCCACGCTGTTAATCGGCCCATTCCTCAGTCGACCAATCACCGGCTCCCGACGATTGACAGTACTCGTTGAGCACATTCCGCATTTTCACCAGTCTGTGTAACGGGAAGACATATGGTAGAAGCCAAAGTAAGACACGATCCAGGTCTGGTGTGGCTCTTCCGTACACTCCGAGACAGTGATAGAACACTAGGAAAAAGCGAATCGCAATTCTTCGCACTGCCATAATTTTTCGGGTACGACTGCTTTTTTGAGAAGCGATTCGATTGCCGTTGCCAGCCTGTGAGAAAAAAATTTAACTTAATTGTTATTTAAAGGTGGGGTCGCGCTAGTGGGGAAATTGCTTTAAACCTAGGGTACCACAATGACCGAATTTCATGATATAACAATTCAAAAAAATTTTCTAAATTTTATATGATTGAAAATTGAAAAAATCCAGTTTTTGTCTAATTTTGAATTACCGCCAATTGAACTTTTGTTCTATGGAGCGCGCTTGCACGTTTATCTATTAAATTTATCTACTTTATTTTTTTGGTAATTCGTTTCTGTTATTTTTCCACCAATTGTTAATGTTCGCGGTGTATTTTTGCTCGAATTTTAGAGAAGAAGTCAAAATAAATGCTTTTCGATTAAAAAAAGCACGATAAAATCAGTGAAATTAATTAATTAACAGGTTTGAAAACGTTTAAGATACATTTGTCATTTTTACGCCTGTAACCGTGCATTTTAATTGAAAATTTGTTTATCTGGACTTTATCTCTAAAATTCGAGAAAATACACCGGAAACATTAAAACTCGGTGGAAAAACCTACAAAAACTACAACATAAAATAACTTAAAAAGCGTGCAAGCGCGCTTCATCGAACAAATTCATTTGGCGGTAATTCTAGAAATTAGGGGGGAAAACTGAGATTTTTTCAAGTTTCAAAAAATCATATAAAATCTGGAAAATTTTTTTGGATTTTCTATCATTATATTGGGTCATTACCATAGGCGTGTTTCAAAGCAATTTCCCCACTGGCGCTACTCCACATTAAATCTCTGACGGTTTTTTTTCGGTTTTCCTTGAAAATCCTCTAAAAATCGATTATTTGTATTGCGTTGTTTTTCCGGGATTTTTCTCGGATTTCCCACGGGGTATCCGGCCTTCCTCACTGAATGTTTCGCTCCATTGACAATGTCTCGCGTGTACTCCACACGGAAAACAAATCACATTTAGTTTTACATAAAATTGACCAGAGACGCGGCAGCCAACGCGCCGTAAATTTACCCCAGATGCCTGGCCTAGTTCGGCGAAAACCCTTCCAGTTCAGTGTATGAGTGAAGCCAGAAATCCATGTTTTCCTCGAAAAAAACCTCTAAAAATCGAGTTTGTAATAAAAATTGCGTTGTTTCTTCGGTTTTTTTTACAATTTGAGGGTTTTTTGTCTTTTTGTTTTAACACGGATTTTTGGCTTCCCTCATATCTTGAAATGGAAGAGGCCTTTCTGCCGAACTAGGCCTGGCCATAACTGGGGGAGATTTACGGCGCGTTGCGTAACAGTGCCACGCGTCTCGATTTTAGTTGTAAAAGTAAATGGACTCATTGTCCGGGTGGAGTACGGCGATTGTCATTATGGAGCGCGAAAAGCAACGAGGAAGGCCAGAAGCCCGTGCGGAAAGACGGGGATCTCAAACGGGGACAATCTACAAAAAAATTAGTTTAAAAAAGACTTCCTCAAAAAAATTCGAAAATTGTGGTTTTCTCTTTTTTTCATAATTTTTTGTATTTTGATAAATTTTTTGCGACATCAAAAAATGGAAGAACTTTGTTCGCTTTTTGAATTTTTGGTGAAAGAAGAAAATTTCGAAAATTCGTTAGGGAATCGATAAATTTTTATCAAAAATCGATATTTTAAAATTATTTTTTGCAGTTTATAAAAAATCAAGATTTTTTCGCATTTCGCGCGTAATTTTCATTTTTGTCGTTTTTTTCTTAATTTTCCGAAATTTCTGAAATTTTTTCTTTTCTTGTTCTGAAGCTTATGCCTAAGGACCTAAGCCTAAGCCTGAGCCTAAACTCCTAAAACGCACCACTTCCAACCAGCTCCGGAGCACAGAGCACCTGCTCCAGTGTACAGAGCCTGGATTCAGCCTCAATTGCACTCGATTTGGCTGACGTCGCTGACGAGCAGAAGCTCAACGAGATGAAACGTCTCGAAACTATGCTCATCTTGGAGCAGTGGACCAGCTTTTCCTGTAGAAATGTTGTGGTCGAATTAATGCGAAATATGGGAAAATTCGGGTTCAAATCGATGAAAAATCGTGCAAAAACGAACATTCGTCGTTAATGTGTCGAGCTCTTTGTTTCAAGGCACACGGCTCACACAATCCCTGTTCAAGTCGGTGAATCTTGAAATGCTCACCTGCACATCTGACGATTTGCCCTTTCGGGCAAACATTTTCCTGTGATTTTAGGCGATTTTCTGCAAATTTTCGCTGTTCAAACGTTTAAAATCGACGGGAAAATGCGTATTTTTTACGAAATATGCGAGAAATAGTGATTTTATTCGAAAAAATCAATATAAATAAGGAAAAGAACTACAGGAGTAATTTAAAGGCGCATACCTCGAAAGTTAAAATCGTGCCAGGACCCGCCGCAATTTGGAATCGGTTTTTAAATGAAAACTTTTTGCTTTACTAAAAATTAAAATTCACTGAAAATTTCGGTTAAACTCTGACTATTAACACGAATCTTATCACAAACTATGACTTTCTAGTGACAATGGCCAATTTTGTGTGTAAAAAATTTTTTCAGTGTAAAATGTTTTTTTTTGAAACTAAAATTTCGAGCTTGAAACTAGAAAATGTCAAGTAAAAAAGTCGTGCATTTTTAAGCGAAAAATAACGTTTATTTCCAAGTTTTCGCCTATAATTCACACAAAAAATACTGACTCAGCAAACAATGTAGGGAGCATCCCGAAAATGGTGATGGTAGAGCAAAAACGAAAAGTCGATGAATTATTTTAGAGAGAGAGGTAATTTTATACAATTTTTCAGGAATGGAGGTTAAAAAAAAGAGTAGAAACCATTAAGGCAAAACGATCCAGCTTGAAACCGATTTAGAAACTGCAACTCCCAGAAAACGAAGCAAATAAGAAAATCCCACAAAAAATCCGAATTTCATTGCAGTTTTCGACCGCCGTAATTCAGCCAACCAGGGTGAGTGTTCAATTATTAAAGAAGAAGCACATATATACATATAACATTATTCAAAGGACATAATCCATATAAAGTCTGTCAAAACGGTAAAGGTTCTTGTATCCAAAAACACATTTGGCCCCCTCTTTCGAAAAGAGAGAGCATGGGAATCGGAGAGGACGGTGCGAAAGACCCAGACATCGAGATGACACTTTTTGACAGTCCAACAGCCTGTGTGTGTCTGTGGTGTGTGTGAGTCTCTGTGATTGAGTGAAAGCGCTTTTGGGAATATATAGTACCTGGTAGAAATTTAATTTAAAATGATAAAAAATTTCTTGGGATTTTTTTTTTTGAGTACTGTAGTACACCACAAAAGGACGTAATGTTCAACTGCGCCCATGGAGTCCCAATGACGTAATATCATGATAAAAAAATTTTGAAATTGGAAAAAACTCAGGTCTTCCCCCCCCCCCTAATGTCTTCCAATTAGAACTTGCGCCAATTGAATTCGTTCGGCGGAGCGCGCTTGCATTATTTTTATTATATTTAAATTTCGCTCTGTGTTGTAATTTCACTGATTTGTGTTCATTTTTTGGGGGTTTTTAATTGGCAAAAGAGAGAAAAATGCAAGATCAATGCAAATTGTTCACTAAAAAATCACTGAAAATAGGTAATACTGTGAAATATGCTAATTTCAGGCTTGGTGTAGTCGGAACTCATAATTTCGTAGTTTTACCCATAGTCTATCATTTTTTAATGAACATCTGCATTTATCTTTTTTTTTTAAATTGAATTGCTATTAAAAATCCCCAAAAAATGAAGAAAATCAGATAATTAGAAACAATAAAATAAATTTATAAAAATAATGCAAGTGCGCTCCACCGAACGAAGCCAATTGGCGGGAGTTCAAATAGCGAGAATTAGAGGGAAAACTGAGATTACTTTTTCAATTTTGAAAAACATCATAAAAAATACGCATTTTAGCTTAAAAACTCGAAAAATCATACAAAAATTAATCTGCACCAAGTTGTCCACGAGTAGTACCTTGCGTCGCCTGGTTGCAGAAATGGCATAGATTTCGATTAGATTAAAAGCTTAAAAATCATTTTTTTTTACCCAATTTCCATTTAAATATCCTAATTCCAGCTTAATCTCAATTTTCTTGAAAGAAGTGCAAATATAGATTAACGTAAAAATTCTACGCTGCGAGACCCATGCCCCCATAAATCGCCTGCGCCTTTATTGATGATTTATATTTATTTTCTCTCTCAACCAGCGATGAACATCACGTTTTTGAACGAATTTTCGAAAAAATAAGACAAATTTCTATTTTATAAACCACTTTATACCGTGGGTCGTCGCTAAATAGCAAATTTTGACGCAAAACAAAAACGAACAGACAACGGAAAATCGATTGAAAACAAGTGAGAACACAGCAAAACTAGTCCTAATTAATTAAAGGCGCATCACGTGGAAAAGAAAACTGTTGTGGAAGAATAAAAAATGGAACATGAGGGGAAAGATTACACTAAAATAGTAAAAGATGCAGCAAGATTAAGATTATTTCTCGTGGAAAAATCGAGTCCCCTTCCGCCCAGGAATTCATCATAATTTTCGACTTTTTTTCGGAGATTGCTGCACTTTGTCGGCTGCTCCGGTGGTTTTTGGCAGGTTTTGAGAGCGCTGAAAGATTTGAATTTTTTGGAATTTCGAGAAATTTCTTGTTTTCTACCCGAAGCGCTTTGAATATGGCCAGCTGCATTTCCAGCTTGCATTGTCCGTTCAGTGACTTTGACCCTTCCAGTTTTCTGAAAAAAAAACACGAGTTTTTGAATTTACTTTCTGATTTAACGATTTCTGGTTTCCCTCAAAGAATTGAAATGGAAGAGTTTTTGCCGAACTAGAGGCCATATCTGTAGATTTACGGCGACCGTTGCGTGTCGCGTCGCGGCTCGCTTTTAGTTGTAAAGCTAAATGTGATTTGTCCGTGTGGAGTACACTACTTTACCCTCCCACGCGTTGTCCGGCAGGCGATAGCGCGAAAAATTCAAAGAGGAAGGCCAGAACTCCGTGATTTTTCTTTTTCGCGTAGATTTCGCAGTTTCGGACTGTTTATCAGGTCTAATCAGCGGAATTTTCGGTGATCCCGCCAATCTCGGTTATTTTCTGAGCCTTTTTCGCTCAGGTTCTGGGATTTCAGCTGTTAGAGCAATCTTTGTATATTTAGACAAGTTTCTTGAAGTCCAACGCAATTTTTTCAGTAGTATTCACAGTTTCCGGCAATTTTTCAGAGCAACTCTTCGAAATTTCGACAAGTTTTCTGACAGACTTTGTAGATTTCGTCTGACGGTTTTTCTGCAAATCCCGGTATTTTCGGCTCGCGGAGGACTCCCAGCTGCTCTTATTGTTCAGCATTGTCTGCTCAGTAGCGGGCGCGTCTTGATTTTCAGTAGAATTCGCAGTTTTCGGCAATTTTTCTTAGAATCTTCAAAATTTTGATAAGTTTTCTGTTCCGGCGTAGATTTCGCAATTTCTGGCGGTTTTTCCGCAAATCTCAGTGATTTTGGGCTCGGGGAGCCCCTTCCAGCTTCTCTATTGTTCAGAATTGGCTGCTCAGCAGCGGGGGCGTCTTGATTTTCAGTAGAATTCGCATTTTCCGGCCACTAATTGTTCTGAGGTAATCTTTGGAATCTCGGTTTTCTGACTTTTGGCGTATACGCAGTTTCTGGTGATTTTTAACCCGGCACGATGAGCTCCCAGCTTCTTCATTATTCAGCCTTTTCAGCTGGGCTTCTTGAGAGCTTGTAATCACGTCCGTCGTAATTGGCCTCTGAATCATCATCCGAAACCAAATTGGCGTCGATTATTTCCTGAAAAAATCGATAAATTTTTTTGCTTTTTTTTGCTTTCTCATAGTCTGCTTTTCCCACTTTCCCGCAATTTCTCAAAACACGGCGTTGGAACGTATCCTGGTCGCCGATCGAACTGGATAACTGGCCGGCTGGCGATAAAGAGATCGGCGAAATCTGCTACTTTCTCGTCAGATGAAACCTCGGTTTTTCTGCTAAAACCTACTCAAAATTTCCACTGGCTAAAATCACCTGATAACATTACATTATCATCATTTCCGGGCATTTGTACTTGACGAAAAAAAAGCGGAAAATATTTAGGATTTCGAAAATGAAGCGAAGGTTACGGTACACTAAGGCACATGGCGTAAAATATTCCGCAGGACTCGCCGCGATTTAGGATTTTCACTATTTTTTTTGGGCAAAAGTTGACATTTTACAGAATAGAATACTAAATTGTGTTGATAAATTGTTTATTTGGTTTTCAAATTTAAATCTAAACTGTAAATTTTAAATGTTCCCCCAAATATTCGCAAATTCCCTTCAAACCAAGTTTTCTAGCACAACCGTAATCCCCGAGCAATCGCGCTCCACCAACCTACACACCGCGAATTTTGAATTACATCCCTCATAATTAATTGTTTTTGCCATTTTTTTGCTATTTCCAGTGGATTTTAATGAGTAAAAGCCTACAAACCGACGAAAATGGCGGTGTCAGTGTAAGTCCATCAAATACATATTTTGCTACACGCTGGAATGCTCTCTACGCATCATACACCTCATCAAGCAAGAAAAAGACTCCAATCTCCTCGAAAAGCGCTATAATGACTGTCTATACGGCAGAAATGAGCGCAGAGGTTTTAGCGAATGAATGCCTGTTTTAAGAGCAAGTATAAGAATTCAGAAAAATTCACCTGCAAATCGTGCTAAATACCACCGCTACCGGACAGCCCGCAGTAGTGTGCCATGACGTCACAGCAGTTGTACACTTGCAAAGCGTTGCAAAATGGTAAGTGTACTGTCGAAATTCGCTGTAAGACCTAAAAGACCACAAAAATGGAAAATATCTGAAAACCTCACGATGCTCGTTAATGTTCCAAATGTTCAATGCGCGCCGCGAAAGCTCAACGTCTTCATGAAATCTCTCCAAGCAAAGTTGGATATTATGAAAATGGAGAAAAGCCCAATTTCAGCAGTGTAAGATAAATTATCGAAAAATCAATAAAAATCCCAACTTTCAGACCCCGGCAATTCTAACACGTCCGCCGGCAGCAGGGTGCTGAGCCCGCTGACGCAGCGAAATGCGAAAAGTGAAGATTAGCTACGCGAACCGTCGGCGCTGGCGAGACCTTGAATTCGAAAGACCCACACCGAAGCGGCGGTAATTTGAAATTTTCACATTAAAAAAAAATCGCGAATTTCAGCACTTCCTCAATGAATTTGCTAGCAAGCACGCTTGCGGCTGAAAATCGTTATGAACTCGATCGATTGGGCTGAAAAGGACGACCGCTGCAGTTTTGCTAGAGATGATCGTGAAAAAGCCTCTGCAGCTTCAAAAATCCGTGAAAAATCGATAAAATTTCGTTTTTGTTCCGTGACATTCCAGGTGTTTTAGTCCAAAAGCAGCCTACGGATTTGCTTCCCTCATAAATTGTAATGGAAGAGTTGCCGAACTCCAAGCCACATCTGGGGTAGATTTACCGCGCGTTGCGCCTCTTTAGTTGTAAAACCAAATGTATTTCTCCGTGTGAGGTACACCACTTTCCCATTGCCCGGCGGGTGATTTTCAATGGAGCGCGAAAAATGCAATTAGGAAGCTCAGAAACCCGTGACAAAAGTGTCACGCGGGTTTCAAAGTAGAGGTGCAAGTTCGCGCTGCACCGCTCCACGGTGCTTGGCGGCAAAACCAGAATTCGCTGATTTCAAGCATTTTCCGTCGTTTTTCATGATTTATCATGTCGAAATAGTGTTTGAAATATGTCTTTAATGCTGGGAAAAGTGAATATTAAAAATTTTGACACGTTGAAAAACTGAAAAAATTATCGGAAAAGTGTATTTTGTGAGTTTTTACTTAATTTTCTCGGGGTTTTTAAAAAAATTATTTCTACATAAAAATTGATGAAAACAGCATATGAAGTGCAAAAAATAAAGAAGACTTACATAAATTTTGACAAAAATAGATCACGAAAAACAATAAAAAAAGTCGAAAAATGATTGGAAACGGAGAATTTTTCCATTTTTATGTAGAAATTTTGAATTTTTTAACAAAATTTTCTCAATTTTGAAACACAAAACATGATTTTAAAAATTATTGAAGATATACTCTTGAATTTTTAGTTGCGCCAATAACGGGACTCACGGAGTGACCATGGAGCGCTTGCATCTCGATTTTAAAATTGGTATGAATTTTTCGCGCTCCATAGACACACCTGCCTATAGGACAACGGGTAAGTGTCGTGTACTCCACCCGGACAAATATTTAACTAGAATCGAGCCGCGACGCGACACGCAACGCGCCGTAAGTCTACTGAGCCAAAATGGCCTAGTTCGGGAAAAACTCTTCCATATTCATGAGGGAAGCCAGAAACCCGTGTTTCTAGAAAATCAAGAATTTCTTTGGGAAAAAATGCCAACAATCCCAGACCTAATTCTCAGGGCTAATTTTTCCCCGAAACAGACAACAGACCCTTGTCTCCCTGTTACAAAATCATTCAAAGATGCTCCTGCGATTTCCGAACGTCAGCTGTTGAGCAAAAGGTGGTCCGATGTGTGATAAATGTAATTTTTCGAAAAAAAAATTTATCGAAATTTGCAGTCACGAACGCGAGTGTCTTCTTCAACACGGGATCCGCTGGAACCGGAAAATCTGTAATTCTCCGGAGTATCATTAAAATGTCCCGCCACATATCACCGCAGCGACAAGGTAGGGGATCACTTTGAAATATTTGCAAAAAATTTCTCGTATCAAGACCTCAAAAAATTTTCATGTACCTTTCAAAAATAGAACGACCTTTTTTAATTAAAAAATCATTCAAAAAGGAAAATTTGGGAAAAAAAATCATTAATTCTTTAATTAATAATTGTTTATTTGTCACAAGAAATAGCTACACCGGAAGATAAAGAAAAAAAGTAAATAAAAAAGATGTGTGGACAAATAAGTAAATGTCCAATTGGACCAGCTTTAGCCCGGGAGGTTAAGTTGGGGGGAAGAGGGTGTCAAATGGGATGGAGTCTAGGCGCGACGCAAATGCATTTGGAGTTAACAGTATAGGGAATGAAACGTTTTGCTATTCGATTCCACAACGACAAGTTAACATGTAGAAAACATTTAGACGGAACACCACAGACAACAAGTAGATAGGGGTGAGGAGTAGAGCGTGAAGCTCGAACGAACGATATAAGGTCGGGAAGTAATACTCACTTGAAATAATATTTTTATGGAAGGTTCGGAAGATTTGAAGAACCCGTCTATGGTGGGTGGACAATAAATTAAATTGGGAAAGCCTACTACCGTATGACGAGTAAGATAAATTGCACCTTTGAAAGACACACATTGAGAAAAACCGGAGGGGAGATTCTAGTTATTTCGTGCGGCAAGTTCGGTAGAGTTGGGAAGCGGGAAGAGCTCGCAGCGATATTCGAGTACAGGGCGGTGCTTATGTAAACATTGAACAGTTAAAATAGAATTCGGGACTTTCCTCAGAGCGGAATGAACGATGGAGTTGGCACTTAACCACGGAGTATTAGAAACCAGTCTGATTAATATGATTAACAAAAAATTTGGTATCGACAATGACTATGCTTCCAAGATCTCTGATAGATAAATCACGCGGTTTAATTTCCACCCGATTTAAACAGTATTTATGACGCCCGGGGGTTCTTTTTTCCGAAATGTAATACGGCGGTTTTGTGCTCAGCAAGATGACGCCATTTTTTACACAAATCAGCGACTTGATGCTTGTTTGGATAGAGGTATCAGGGGGTCCGCTCCGAGTAATTTTAGATCGTCGGCAAAGGCTGTAACATGGACATCAGGAGGGAACAAATCGCTCTAATAACCCATTAATATACAAAAGAAAGCGGAATGGTAAAAGAAAAAACCGTAAAAAATCAGCAAATTTCGAAAAAAAATCGTAAAAAATTGAGACCTTTGGAAATAAAAATCTAGCAAAATTTGAAAAAAAAATAGTTTAAGATTCAGAAATTTATTTTAAAAAATCATTAAGAATTCAGCAAAAAAATAAAACAAATAAATCTGTAAAATTAAAAAAATAACCAGTAGAATTTCAAAAAAAATTGTTTATTCAGCAAATCGTCTTCTAAAAAAAAATCATAATAAAATGATAAAAATTAAAAACGTAAAAAAATTTAAAATCTGCAAAATTTGAAAAAAATCGTTTAAAATTCAGCAAATTTCGAAAAAAAAAGCATTAAAAAAGCGAGAAATGGGAAAAGCACAATTTTTTAAAATTTATTGAAAAAAATTAAAAATTCATGGAAAAACCTGCAAAATTATTTTTTAAAAACCGGTAAAAATTCAGCAATGGAAAAAAATCTTTTAAGAAAATCAGCAAATTTCGAAAAAATAAAACATTAAAAATACAAAATTAAAACTTTTAGAACATCATTAAAATAATAGCCAAACCGTAAAAAATCAACAAATTTCGGAAAAACTTTACGTGTTCGTTAAAACTCCAGCAAACGTCTAAAAAAAAGCATTTAAAAAGGAGATACAAGAAACATCAAAAATCGAGACAATTGGAAAAAAAATTCGTTAAAAATTAACCCAAATATTTGCTGAATTTTTTAGATTTCTTTTTTTTAAACTAAATTTGCTGAATTTTTTAAAAAGACAATTCAGCAAAACTTAATACAACTAAAAAATTCAGCAAATTTCTTTTTTAAAAATCGTTAATAATTGCATCGGGAAAACTTGGAAAAATTGTGCAAAATTCAGAACAAAAATTTCAAAATTTTCCCAATTTTTATTAATTATTTAGTTTTCAGAATTGATTAATAGTGAAAAATTCATAAAAAATTCAACAAAATTTAGAATTCAAAATTTCATTTTCATGGGTCCCGCCACGATCCACTCCAACCTACAAAAAATCATGTAATTTCCAGGCGTTGCGGCATCCCAAATCGGCGGAATCACACTTCACGCGTTTTGCGGTTTTCGCTACGAACATTCGACGCCGTAAGCAGTGCCGAAAACATGTTGTTACGCCAAAATCACATGGTCCGACAGTGGAAACAATGCTCACACTTGATATGACGGATTTCATACCATGATTGATCGCTTTGCAGGTTTGAAGCTCTCGAATATGTGAGCTCATTGCGTTTTGATCTACAAAAAATGCGAGAGTTTTCGCAGCATTGCTCATTTGATCTACAGAAAATGGGGGAATTTCGTACTACCAGTATTGCTCCTTTGATCTACAAAAAATGCGGGAATTTTCCCAGCATTCCTCCTTTGATCTACAAAAAATGCGGGAATTCTCCATTGCACATTTGATCTACAAAACATGCGGGAATATTTCAAGTGTGACGTCAGCGCACTCATGCGAAATCTGCATGAAAAGTCTGCGTCTCTTCTCCATTTTTCGGAGCTCAAACCAAAATGGGCGGTACCCGAAAATTCCAAAAAAAAAACGATAATTTCCCGTCCCATGTCGCCCGTACGTCCGTAATAACGATAAGCCGTTCGGTAGAATTCAGCTCATTAGGTTCACTGGAGATTTCTTTCAATTACCGCCGTCTCGAAAGATGAACCAGTCTTTTGTTTTGAGGTGTGCGGAATTTCGGAGCATTTGGACCGTCTAACTATTAAAAAAATTATTTTGCAGAGCGCAGCCTGGAGCCGATGTATCCAAAAAACGATTGTCCTGAAAAATGTGAAACGACATAATGACAATGTTTTTGTAAATAATAACGTTAGAGTTGGAAAGTACGTAAACTACTGGATAAATTTAAAAATTTCGAATTTTTCAGGGTTTTTTAGTACTGGAAATATTGATTTTTCAGTGAAATTCCAATAAAAGCTGGAAATTTTCCACAGAAAAAGGGAAATGAAAATATGAAAATTTGTAATTAATTTCGAAAAATGCAGAAAATCCCAAAGCCTTCCAGAAAAGCTGGAAATTTCATAAAAATTTCGGAAAATCTGAAATTTTCAGAAAATACAAAAAAAGCAAAAAATCTCGAAAACCTTCCAGATAAGCTGGAAAATTTTAGAAATTTCCAAAAAAATAAATTACTACTGAAAGTTTCATAAAATTCACTGATTTCTGTCTTCCTTCTTGTAATGGATGAGTTTTGCCGAATCAACTAGGCCATTTGGTTCGGCCAGATGTAGATTTACCGGTTTGCGCGTTGCGTGTCGCGTCGCGAGCTCGATTACTTAGTTGTAGATAAAATGTATTAGTCAGTGTGGAGTACACGACACTTTCCCATGTGTTGTCCGGCAGGTGATTGTCAATGGAGCGCAAAAAATTCAACGAGTCCAGAACCCCGTGATAGAGCGGCCAACACGGGGTTCTGGCTTTCCTCATTTCATATTTCGCGCTCCATTGACAATCACCTGCCGGATAACACGGTGGAGTGTCGTGTACTCCACACGGACAAATACCTTTATTTAGAACTACTAATTGAGCCGCGACGCGACACGCTACGCGCCGGAAACCTACCAGAAATGGAGATGCTAGTTCGGCAAAAACTCTTACCATTTCAACTCTTTATGAGGGAAGCCAGAAATCCGTGTGATTCCAAAAAGAAGCTCCAAAAAAAAATTCCAAAAAAATCTCCATAGCCTTCCAGAACCGCTGGAAATTTCAGTCCCCTAAAATTGATAAAAATTCGAATAAATTCTCAAAATTGTTAGAAAATCAGTGAAAATTTGGAAAATTCGGAAATTAAACAATTTTTTTTGGAATTTAAAATTTAGAATTCTTCGTACGAAAGATGCTCCAGAAAACTTGTAAAAATTTAATTTTTTTTTTGAAATTTCCAAAAAATTTATTTATTTTCAGATGCGGCTTCAAATCAGCTGATATTCTAAAGTAATCCTCGAAAAATCAATTCCTGAGCCATCCAGCGTAATTCCAAACAAACTGTGCACCAGATGACGCCGATCGAATTAACAGCTCAAGCATCGAGACAACACAAGCGCGAAAACCTTGCAGAGCGCCTACGATGACGAGAGTGACGCACGCCAAGGTCCGTACGTTGCAGCACAGAAGAACCTTGTAGGCTGAAAGTTGGAGCTCAGGTGATGCTCATCAAGAATATCGATGTGAGGGACTTTGTAATGGGTCACGTGGATCTATGGTGAAATTTTCTGTGAAAACGGGAATCTCTATGATCCGATTTGTATCGCAAGCCGATGCTTCCATTGAGGCACGTTTCACAGAAATGACCATTTTATGGGCGTGGCTTTCTTTTTCGAAAATTTATTTTTTCCAAAATTTCTACATGGATTTTTCTCTACAATGGAAAAAACCCCCGAAATATTGTAAAAAATTTGAAATTTATCGGAAAAAAATAAAATTTTCTCTCTTACAATTAGGCTTAGGCTTAAGCTTCTAGGCCTGGGCTTAGTCTTAGGTTTATGCTTAAATTTGAAAAAAAAAATTCTTGCAATTTTTTCCAGATTTTTCCGTTTTTTTTTTCACAGAAAATCTAAGATTTTCGATTTCTACTTTCAAAAAAAATGAGTTAAAAAAAATTACGCAAATTTTGTAGAAATTTTTCTTTTTTTTTTCTTAAAAATTAGGCTTAGGAAGCTTAGGCTTATGCTTAGGCTTAGGCTTTGGCTAATCGCAGGACTATGCTTTGGGTTAGAAGACTTGCGCAGACAAGCCTAATCCTAAGCCTAACCCTCTTAAAAAGTTACAAGACGGTTTTTCCTTGCGCTGGGAGCTCAAAAGAAGAAAAGAAAAAGAGCTATTCGGACTTAGTGTGCCTATCTGTAATAAAACATTGGAAATCCCTATGACGCACTTAAGCCTACGGCCCGCAAAACATACTAGGATGCCCAACTGGAATAAAATATTAGAAATCCTTATGACACACCGGCGGTATGGCGCGGACTTAAGCCTAAATGGCCACTTTTATCAAAATACATTTGAGCTCGTCTTGTGTTTTACGTTGACTCCTCTGAGGCAACTCAAAAATATTCTGTGGATATTCTGCAGAAATCAGTTTAAATGAAGACAAGAGATTACTAAGAAACTTGGAGATTTCATAATATTTGGGGGGATGCGAGCATCCATTGGAAATTTGCCATTTGATACTTTTAGAGGCAAAAGTCCAAGTCGTAACAAGCTCACAGTGGGCTCTCAAATCATCAAATTGTAACGAAGAAACGATCGATATAACGAAACAATTTTACAAAGTCACTTTGGTAGCTCATATCTCCGTGGATAAAATTTTTACAGACGTAAAAGTCATCAACTGATATGTTGTTGATATGGTTGTAAAGAACAAGTTTGTTTGAAAAGTTTTTTTTACCAAAAAATTTTCGTCGTGTTTCAAAGAAATAGTAACGGAATAGCATCATAAAAATAACAACAGCAGTTGCGCCGCGCACTTCACGCGGTTATTCTTAAACGGGAGATGAGCTACCAGAGTGAAATTGGATGGCCCTCCAATGCTTCGTTAAAGTTCACGGCCATTTTCAGGATCTTTGAGAGCCCGCCGTGAGCTTGGTTTTCGAGGAGTTATATAAATTGACCCCTCCAGATTAAAGGAGGACTTTTATATAATCACGATGGTATTTAATTCCGATGAGTAATCCATTTTTCTTTTCACATTTGTCAAACAAAACTAAGTTTTAAATTAAGGCGGGATATACTAAGGTGTGATAACATATGTTATTCATGTTTAAGTTTAAATAAAGTTTTTTTTTAATTTTTGCTAAAAAACGAATTACAACCGCCTCGCTCAAATGTATTTTATAAAAGTGGCTATTTAGGCTTAAGCCGCGCCATACCGCCGGTGTGTCATGAGGATTTCCAATATTTTATTCCAGTTGGGCATCCTAGTATGTTTTTCGGGCCTTAAGGCTTAAATGTCATAAGGATTTCCAATATTTTATAGTTGGGCATCCTAGTTTTTTTTTTTCAGGCCCTTAGCCGTAAGTGTGTCATAAGGATTTCCAATGTTTTATTCCAGTAGGGCACCCTAAGTATAAATAGCTCTAGGGCTTTTCTTTACTTTTGCGCCTCCAAGCGCAAGGAAAAACCTTCATGTAAAAGCTTTTTAAGAGGGTTTCATCATTATATTTATTGAAATCGGGGCGAAGCCCTGATTTTGAATCCATATTTTTGTCTTTGTCTTCCACTTGATCCCTGCAAACTAGGAAAGAGAATGTTTTCTTTCTGATGAAGTAAAAATCATCATAAAATCTTGAAAACGAGCAGGAGGTAATATTTGAATATATTGGGTTGTAAATGTGTGTCTCCCCTTGTGGGTGGGGTGGCGATGTGCTGGCAGCCAATCTGCCTTCAACGTGTATCTCCCGCCTGTATCGCCCTTCAAAGTGAGAATTGGGTTACCAAAATTTGAGGGAATCTGATGAGAAAAGGTGAGGATTTCAAAAATATTATTGTTGACACACCAGACCAAACTTTAGCCTGGGCGAAGAGACAGAAAATTAGGAATTTTTTGAAAACTTTCAAACTGGCACAAAATTATTTCACAAACAAAACTCTTTTCACATATTGTTAAAACAGATGCCATTTTCCAATAATCAATATTGTCCATTGAACACAGAAAAGAAAACGAAGATTCTATCAAAAAATGAGTGAAAAATCGCAATTTAAAAATCGAAAAAATCCGTGCTGAACTCGAGTTTTGGCGGTGCTGAAAAGAAAATTTTCACTAAAATTTTTTGGAAACTTAGTTTTTCGGATTTAGCGTCAAATTTTGAATCTATACAAAAAAAAAATTTTGAACTCAGATTGAGTGGATAATAAACGCTCAAAGTTGAAAATTGACAACGCAAAAACGGCGTGAGTAACTTGCTTCAAGGTCGGCTGTCTCAGTGAGTTTTCACCCAATTTTCCCCAAATTTTTTTGCTCTATCGCTTTAGAAATATTTTCTTTGTGGTAATTATGTTTTCCTCAAAATCAAGATAATATCTTAAACGACCGCCATCCTATTTTACAAGAAAAAAAAAGTCTTTGGAAGAAAAATCAGAAATTTTCGGCGTCGATTTTCAAAATGACAAAATCACTTTTTCGTAATAAACTTATTTAAATGTATTTTGATAAAAGTGGGTATTTAGGCTTAAGCCGCGCCATACCGCCGGTGTGGGGGTCATAAGGACCACTATTTTATTCCGATGGAGTTGGGCATCCTTGTATGTTTTTCGGGCCTTTAGGCTTAAGTGTGTTATAAGGATTTCCACGATATTTTATTCCAGTGGGGCATCCTAGTTTTTTTTTCGGGCCCTAAGAGCGGCTGTGTCATAAGGATTTCCAATGTTTTATTCCAGTTGGGCACCCTAAGTCTGGGTGAATAGCTTTTCATTTCTTTTGGTCGCCCTCCAAGCGCAAGGAAAAACCTTCTTGCTTAACGATTTTTTAAGAGCGTTAGGCTTATGCTTAAGCTTAGAGTTAGGGTTGGGGTTAGGCGTAGGCGTAGGCTTACGTTTACGGCTTCGGCTTCAGGAATATTTAAAACAAAAATCGAAAAATAGATTTTGGGAAAAAAAATCGTGATAAAGCCTGCTAAAATTTTCACAAAAATTAAATTTTTCAAATTTTTCAAATTCCTAAGTGATTTTGGTCTCGCAGCGAAAAAACATCCAACTACAGTAACCCTCGCCCTCTCCAATTTTCAGCTCCCCGGCTCCAATGTTCTCGCATTCCAGGGTGTGATACTCCGTTGATTCGCCGTGAACTCCCACTCCAACTCGCCTGGGCCATCTCCATTCACAAATCGCAGGGAAGCTCGACAGTCCGGGAATGTTGAAGCGCGTTTTCGCCGACGGACAGGCGTATGTGGCGTTGTCGCACTCAAGATCAATGGACGGCGGCAATTAATTATCGGCTTCGAGCGTTGTGTCCGAGCGAATTCAAAGGTGAACAGGGGATTTTCGAGATGAAATCTATGATTGCAAATCAGAATGGATGGATGCTGTTAGATATCTCCTTTTCGTGGGTTCTCTCACGTGGTAGAGTGCTCATTTCGGCTCTACTGTGTAGATCTACAAAAAATGCGGGAGATGAGGAGACTCAGACTTCTCAACTGGTTTCGCATGGTCTAGAACGGCGTTGCTGACGTCACTTTTCTCTCGGCATAAAATTCCCGCATTTAACCGGTAAGGGATCTCTCAGCTACGTGGAAAATTATCGATGTTTTACCGAATTTCAGGTTATCTAGCTTTTTACAAATCCATCGAGGCAGAATGCGACGACGAACAGGACTGGGGAGCCCCTGGTGCTGGGCCTAGTGCTCAAGTCGAGTTCGATCGATTTTTTATTTAAAATTTTTTTGTGATCTCCAAATGTTTCTGTCTTTCTATCTTCCCCCCCACCCCACCAAAATAACCGTTTTCACAACACTCTGTATCATCATAATTCTCACATAAACTATTTCAACGTTGACGTCGCCTCAATTTTTAGTGCTATAAGCGTCATCGGATCTGAAAAAAATGTAAAACTTGAACAAAAAAGCAGGGGGTGGCCTAGAAAGCACAAAAAAAACTCGGACACAGTTCAGGAGCCAGTTTTTGGAAAAAAAAAAACGTCATTTTCGTATAGCCGTCCACACTGAAATTGAAAGAATTCTGGCCGAGTTTTCCAAATTCTAGGCCACCATGCAAACCGACGTTTTGGACGGCAACGTGCCGGTGGCCGTGGCCCCAAAGAAGGAGGGAAAAACTCGGCCACTCTTCTATGTACCCCTCTCGGGGAATTTTTACCATGGCCGAGTTTTTGTGTCTTCTAGGTCAGGCATTTTTCTTAGTCAGTTTCAAAGGAAATACGATACCTGGTCTCGACGCGAAAATTTAATTAAATCCAAAAAGACGTGCGACTTTAAAAAGTACTGTAATTCCAATATACTTGCGCTGTTGGGAAATTTATCGATTTTTCGTATTTTTCAAAAAAAATAATCAAATGTACACAGGGTTCTGTTCTTCCTTAAATTTGATTTATTCGCGCTCCATTGACAATCGCCCGCAGGATAACGCGTGGGAAAATCGTGTACTCCACACGGACATCGACGCGACGCGACACGCAAGTCGCGCCTTGAATCTACCCCAAATATGGCCGAGCCATAAAGGCCTATTCGGCAAACTCTTCCATATCGATTTATGAGGGAAACCAGAAATCCGTGAGGATAGTGAGAAAACAACGAAAAAATCATAAAATTTCCCAACAAGACGAAAGTTGAGATTACAGTAGTCTTTAAAGGCGCACTTTCTCGCATTTAACTTAAATTGGTCGTGGAGAGAGTATTTTTAGCGCAAAACTTCGCATTCCGGGTAGATAATAGAAGAATTGAAACTGACAAATCCGCCGTTTCCTCAAGCAGCAGCGGCACAATAAACATGAAATACACGGCCAACACGAAATGAAGCGGCACCATCGACACAATGAACAACGACATTCGGAGCATGTGCTACAAAACTGTCGGCCGCAACTTTTTCGACGGATTCTTCCCAAAGACGAGATACCCTTGCATCGGGCTACATCGGGGCTTGAACCGACTTCTTCTTCATTACAGCGCTCCCTTCTCTGGGCAGCAGGTAGCGTGTCCACGTGGTATAGGGTGACTCAGTGGTTCTGTGATTAATCGGCGCGAGCTGGAGCATTCTTTGCAGAGTCGCTAGGCGTGAGGCCACGGTAGCGGAGGTGTTGGCTCTGAAAGTAGATTTCATACAGGATGGTTATTTCGGGGAGTACTGTAGTGGTGTTATAGTGGTTACTTGTAGGAGTACCCTGTAGGGGATACGAAATGCAGGGGTAGCAGTACTGAGGGGGGTACTGTAGGAGTACTGTAAGGGTGTGGGGGTACTGTAGGAGTAATGTGGGGGTACTGTAGGAGTACTGTAGGACCACTGTAGGGGAAATGTAAGGATGCTGTAGGAGTAATGTAGATGGTACTGTAAAGGTACTGTAGGGGTGCGCTAGTGATACTGTAGGGATCATGTAGGAGGACTAGGTCCTGAAATAAGGGTACTGTAAGGGTACTGTAGAGGGTTAGTTTTATGTCCCTGTAAGGGTACTGTAGGGGTACTGTAGGTGTACTGTAGGAGTAAAAGTGGATTCACTGTAGGACAATAACGCCAGAGGTACTGTAGGAGCACTGTAGGCGTACTGTAAGGGTACTGTAGATGTACTGATTATGTAAAAGGTCCTGTAGGGGTACTGTAAGAGCACTCTAGGGCCATTGTAGGGGTACTGTATGTACTGTAAGGCTACTGTGATGTACTGTAAGGGTACTGTAGTTGTTCTGTAAAGGATACTGTTGGAGTACTGTAGGGTTACTGTATAAGGGTACTGCAGGGGTGCTGTAGGGATACTGTAGGAGTACTGTAGTGTCTATAGGAAGACGAACTTTTTTTTGAATTTACTCATCGGAGAATCTAATATTTTCTGTCTCCAAATCGATACACCATAAAAATTTTAGGACCCAGAGCTAAAAAAAAATACCAACTTCTCCAATATCATCTCCATCAATTCCAGTTGTTCTGTGCAGTTCGCCATCCCTTCTTCATTCCATCGGCCGATTCTCCAAATCGTCCACCATCTTCACACCCCGCCGACACGCCGGTGTCTCCACATCGTTCCGTACCAGCTTCCGCAATTTTCATAAGATTCTCGACAGACTCGTTAAACTTGCGTTGGCTTGAACAAGTGGGAACCTAGAATCGCCTCGGGAACCGGATTTCCACCCCCTTCCACCAGGAGGCTGACCAGTGTCGTTTTCTGCCTGACGACCTTAGCCAGGACGTGCTCATAGTTGATCATGTAGATTTGCCCGTTTTCAGATATGTTGAATGTTTCAGATGAGGACAATTGAAAATTACCGATTTGATTGTGCGTGTTCATGCACGACAGTAATGAAGGCGAGGCGGCAAATTAAAACTCTGAAAGTTTAGATAATTGTACTTTAGTTGAAATCCTTTTGTTGACAGTCGACTAAAAAAAAAAGCAGGTAGGTAGTAGGTAGGTAGAGTAGGTAGGTAGAGTAGGTAGGTAGGTAGGTAGGTGAGTAGGTAAAGAGAGACACGGTGCATCGATCTGACTTTAAAAATCTCAATCTCGTATCTTAAGCGTCTTTGGTTCCTGTCAGGCAGGTAGGGGGGAGAGTAGGTGTGATCAGGTAGGCAGAGCTCCGGAGTTAATATCTGGTGGATTGTGAGTTGCTAATAGGTAGTGTAGACAGGCAAGCAAGCAAGCAAGCAGTCAGGAAGGTAGGTAGGTAGGTAGGCAGGCAGGTATCAGTTGTCAACTTTTTGATGAATCTAACGGAGCCGAACGAGTTATAAGGAGGCCCAACGTTGCACCAGACATCGGGAATCGACCTAACTTGCAAAACAACTCGTAACTTAAGAGTGTCTTTGGTTCAATTTGGGAGGCAGGTAGGTAGGCGCTTAAGGTAGGTAGGTATATCTTACGCTTCTTGTTTCAAAAATAGTTATATATTAAAAAACAATAAAAATTTTTTGCAAATTTTATCAGTCGACAACTTTTCTTGTTAAAACTAAAAAGAGACGAGATATTGTAAGTGTTGCAAAAGTTGAACGAGACATGGTGCATGGAAGGATGGCTAGGCAGGTAGGTAGGTATTAAGGAGGTAGGTAGGTAGGTAAGCATTCCGTATTTCTCTACTTGCTTATATCCTGGTTGTTATGTGTTGTATCAAAAAATGTTTAACAAAGATAACATAGACTGAAAATATTTAGCACGTAGCAAACTTAAAAAACTAGGTTGGTAGGTAGGTAGGTAGGTAGGTAGATAGGTAGGTAGAAATGCAGGCATGTAAATCTGGTGAAGGTAGGTAAAAGTACTCACGATGGAGAACATCAAGCAAGAAGATCGCCAATTGAAAGTGGTACGGAAGCGAGTTGAGCAAATATTTTAGAGTATTTGTCTAGAAAAAATATTAATAAGTATTCAAAGTTTAAACTAATAATAAAATACCAATTCCGAAAAACTTCATTATAAACAAAATCGTCAGAATCCCACTGGAGAGGACTAAAAGTCACTCGTGTTGGCAGACGTCTGATAAACATCGAGGGTGTGTCCGGGTGGTAGGAGAAGCACATTATCGTGATACTTTGACACTGATAGATTCCTCAATAGAAGCCAACGCTTTTCCGAAAACTGGAATCGAAATGTTCAAAGCATTGAGAATTATTTTCTGGTACTCTTCAACCAGGCATGTTGTACTCCGAGTTTAGATCCGCAGAAAAATCTAAATTTGTATTAGATTGGGCGATACCGTACTTGCCTACCTGCCTACTGGTAGGTAAGCAGCCTACTTATTTTCAACTTACAAACCTCCTACTTTGTAACGTTTATTTCGCAATAATCGATTTCTCGAAATATTTGCATTTCCCCTCGACAAATGATTTCTTTGCGGGAATCTTTAGGAACAGCTGAAAATTTTTTTTTCCGTGTGGCCTTTTCACGGCCACGACGTACCTTAACGCTTACACATGGTGCAGTTGACGTAGTCATGCAAGAACCAATTTATTCGGCGGCGTTCGTTTTCGGTGACGGCGAAGTTTAAGCACGGTATGTAGAACCTTACGGTGGAGACGTTCTTTGATGGCTGGAAGTTATGACGTCATGTATAATTAGGGATGAGATTCCTAGGCCACGTGTGACGTCACAGCAATCCCCGAAACCCTGGCTTTTTCGATGGGCGATTTTTACTACATCGATACTTTCTAGGCATTCATCGAGCGAAACTTTTGTGATACTTTGGCAATGGTCATCAGGTAGACAAACAACGTGATAATTTCTAGGCCACGCTTGCCTCTGTCACGTGGCCGAGATTTCGCGCCAGGACCTAGAACTAGACAGGGTGCATCGACCTAACTTAAACCTCGTATCTCAGTTGCCAGGTAGGTAGGCAGGCAGTCAAGCAGATAGGTAGGTAGGCTGGTATTTTAATTTCATTTCTGCGGCTACAACACAATTTCTCTTCCAATCAAGGACAAATTTCTAGCGCCACACATGCAGAGTGCGGACTAATAATTAAAGTGTTTTACGACAAGGCCGAGAAAAGAGAAACCTAGGCCACTAATTTGTAGTGAGGTGTGATGTAACGCCACTATAAAACTATAGAACTCGCTTGACGCATAAAACTCTGATCATTTGCGGTTTCGAACTTGCATCGTCCTTCCATAGACCGCATCCTGAACGTACACTCTCGTAAATTGCGGCCTAAATTGTATAGACCCATTAAAGGGTACAAAATATGGGAATAATGGTGAATCCGGAGCGATTATCATCCAAATACACGAGAGATTACTTCGATACATAACCTCGAAGAGCAACAATTTCCCCACGAAGAATATCAGCAGAGCTGTGAGCAGGAGAGGCGATTATTATCTGGCGGATTGTGCGCTGAAAGTAGGAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAAGTATCGGGTGGTAGGTAGGGAGGCAGGTATCAGCTGCCGACTTTTCGATAAATATTAGACGGAGCGCCGAAATATAAATTGCCAAAGTTGTACCAGACATGGTGCATCGACCTTACTTAAACAACTAGGTGGTCTAGGTAGGCAGGCAGAGGCAAGTAGGTAAACTCACCGAATGCCTTAAAACAATTGCTAGAACATCGGCATAACCCGAGCTTCTCCCATTCTACGTCGCGACCACAAGCGCGCGCACACTTTTCCGCAGGTTCTCATCATCGCGATCAGCGCAAAAATCCTCGATTATCTCGAATCCACTGGCTCTTTTTTGTGTGCGACGTCTAATCGTTTATAGCTGATCGGCTCGGGAAAACCAATCGTCACACTGCAGCTTCGCATCCTCCAAGCGGAAGCCGTGAGAAAACTGGGCACTGCATAGGAACTAGAAGTAATTTCAGTCTTATTGTTCTGGAAGAAGGCTTTTTTATGGATGGGGTTTGAAAATAATCACTAAAAAAAAAACTTACAGCTGGAACTTTGTTCGATAATGAAACAATTAATCTATAAAAAGCAAATTTTTGACAAAATTTAAAACTTTAACGTGTATGAAGGTCACGTGAAAACTGAAAACAAAAATGTCGAAAAATAGCAAGAAAACGGCCTAGGCACACGTAGACTTATGGTAGGCAGCAAGGCGTAGGGGTTGATCCAGGCAGGGTCACGTCTTGAAGGCAGGTTAGGTATAGGTAGGCATAGGTAGCCATATGTAGGCGTAAAGGCAGGGGCATCTCTAGATCCTTTTTGTATGTGGCAGATTGGCCGCTTTGCAGGCAGGTTGGCAGGTGTGGGTGGCCTAGTAGACCGAAGTTTAAACAAGCGTAAAGTTCCTATAGTAGTAGGTAGGCCAAACCTTTTTTGTAGATGATGAAGTAGGTGTAGGCTGTCGTTTGAAGGCAGTGATGCAGACAAGGTTAGGTCGTCGCAAAGGTTGGCTGGAGGGTAGGCACGTGGGTCAGCAGATAAGCGTAGGCAGGCATAGGCAGGAAGGCATTAGGCAGGTAGACGTAGGCAAGTAGACGTAGACAGGATTTCAAATATGACGTGAAAAGGGGAAAATTTCTTATTCTGCGAGGCGATCCAGTATGCATAGGCAGTTATGGCGTTGGCCGGTAGGCGTTAGGTAGGCGTATGTAGGTAGGCGTCGATGTAGCAGGTAGGCGTAGTCAGGTCCTAGAGATAAGCAGGTAGTCGTGACCGGATAGGCAGGCAGGTAGGCGCATGCAGATAGTCCTAGGCAGGTGGGCGTAGGAACGTAGGCGTTGGCAGGTAGGTGAGGTAGGCGCAGGCAGAGACGTAAGCAGGTAGGCGTAGGCAGGTAGGCGTAGGTAGCTAGGCGAAGGCACGTAGGCGCAGGTAGGCAGGCATAGGTAGGTAGGAGTAGGCGATGCGCACATGAAAACCTTATAAATGTTTCAACCGCATAATCATCATCCCATTTTTCTCTCGATCAAAACGAAAAAATGCCAGCAGCAAACACAATTTGCATCCATTTCTCTCTCTTACTCACTTATATATCCTCACTTTATCCCCCGTTATTCAACCTTCCAAACACTTCCAAAACCTCCAGAACTGCTAGAGAGTAACACGGAAAATATTTGAACTTTTGTCTCGACCAAGTTTTTTTTTATTTTTTCTTTGGATTTCAACAAATTTGATGTCTGTATTTTTTCCATTTTTCGTGCAAAATACGGTAATGAACTAGGTTTTTGCTACGTGGCCTAGAAAATCTCGGCCACCGATTCTGATCTGTTGCAGGCGGCGGCCGCGGCCGAGGGTTTTTCACTTCAATTGATACCAATCCCTCTTTTACGCAAGGAATCACGTGGAGTGTGTCTCTTCATCTTGATTTACGCAGATCTACAAAACATAGCGGGAACTGAGTTCGTATCGTTAAGAACATGCTGACGTCACAGTTTTTTTATCAGCGTGTAAATGTAGAAGCATTCCGGCATTTTTTGTAGATAAAACCGCAATGGGACAGCCTGGCACCACGTGCTCTTCAATGGCAACCGTTATATTTTTTTTGACAAAATCTTGAATTTTCTAGGATTTCAATGAAAATCCAATTTTATACCAAAACTTAAAAAAAAAATGCTAAATTCGACTAGCAAAAAATGCACCCAGTTTTACAAAAAATCTTTATTTCTGAAAAAAAATTCAGTGGAAAATGTCTATAATATTCAGTATTTCATACTACGGAAAACAATTTTTACAACAAGTTTTGATGTGGCCGCGGCCGAGGTTTGCTTTTCCACGTGGTGTCAGACTGTCGTCTCTCGGCTTGATCTTAGATCTAAAAAAAACGCGGAAACTGATTCCTCATGCTATGTTAAGAACGCGCTGACGTCACATTTTTTTGATCGGAAAATTCCCGCATTTTTTGAGCGTTTGAAACCGTGATGGGACAGCCTGGCATTACGTGAAAACAAACAATGCAAGCGCGCTCAAATGTAGTCGAATATATTTGCTCTACCACCAGATAAATTCCACTTTTTCACAATAAACCTAAATATTTTTTGTGTCAAAATCTTGAGAATTCTTAGCATTCGAGAATTTCCGCGTAAACCTACGATTTTGTTATTGTTCAGGGGAACAAGTGAGCCACAAAGCTTCCACTGCTGCTCCGAATTCGATTCCCCTGAGGCATTTTTGTTCGAAAAAACCCTCGTTTGTCATACTCGTCGACTTTCTTCGAAGTTTTTGTTCTAGTTTCAAATAATTTTTCGTCAATACTTGTTCCTTCCGACCCAGCAGATGTTGTTGGGGGGGGGGGATGGGAGAAAAAAAATAAGAGAAGAAGCAGAAACTCGACACTTTTGTGTCCGCATTTCTCGTAAAGTAGATTTTTGAGCTTTCCAAGGCTCAACCACCTAGCAAATTTCGCCGCAGAGTTGATTTCTCCGGGATAGCGTGGGCTTTCTACTGGAGACCTCACTATTTTTTTGCCTTTTAGTAGAGCTTGTTAATCTTTTTTAATAATTTATTGCAGCTCTATGGATTTTCCAAAAAAAACCACCCAAAAGCCCGAAATAATCAAAATTTTCGTTTTTAAAACGCTAAATCCCGTACGACATGCCGTCCAAAGAACACTCACATAACAATGAAGAGATTTCGCCAAAAAAGTGAAATCCAATTCAATTTATTTCAATTTTGAAGAGTGCGTTCGTCTTTTTTCGACAAAAAAATAAGAAAATGTGTACCTTGTGTAGTTTTCAACAGATTTATTGTTTTATTAATTATATAATAGAAATCAAACCTTCTTTCTGCCGACCTGTAGATGGCTACCTACATGCCTAGTTGCAAGTAAGGAGACCTGTGTATCTATCTAGGTACTTATCTCACACCACCTACATACCTACTACTCACCTCCCTACTCATGTAGACATAAGTGATCCTCAAAAAGGAATGCGGTAGATCAAAAGTTTATGGAAATTTATTTCGATTTTCAGGTTTTTAAAATTGCGGAAGATGTTTTCATTTAGATTGAAGATTAGTTTAAATTTTTTTTTAATTCCGTAAGAAAAAAAAATTATTAGTTTATTATTACTCTTTCTATTCCGAATATCTATGTGAAGCTCTTTTTAATTCCTTGGTTTTATATCTAATCTTAAAATCGCTAATTTCTTGTGCACCCAAGAGATTTCGAATTTTCACGGGGTTCTAGCCTTCCTCCTTGAATTTTTCGCGAGTCGCTCCATATAATAGAGAACCGGGCAACGAGTGGGAAAGTCGTGTACTCCACACGGACAAATACATTTAGTTTACAACTGAAACCGAGCCGCAAACACGCAACGTAAATCTACCTCAGATATGGCCGTGCTAAAATGGCCTAGTTCGGCCAAACTTCCATTTCAATTTATGAAGCCCAGAAATACCGTGTAATTTTTGCGCCATCAGAGACGCCATGTGTCGATTTACGAGATTGTTGTATATTTACAATCGGGAATGCGTAATATTTACTAGAATGCGGATTTCCGTTTTTTTTTTATGAAAAACGTCATCCACAAATTAAATTCGGCGATTTTAAAAATCGCGTTAAATATAAAATCAGGGAAATTTTTTAAAATTTTTTCACGTAGGATATCGGAATACAGGGGAAAATTTGGAGGCAAAAACTAATGTCACCCTGATCATGTTTAAATTCTTTAAACTATTGATGAGAATCCTTTTTTCCTAAAATGAAATAATTTCTGACTTTTTTCTCTTTTCAATAAGAAGCTAAAAACAGACGAACCTATTCCAATTTCCCACCACACCAATTCATTCTTTCCGCATTCTTCTTCTTCCATTATTTATCTACCTTTTCCTGCATTCTCTGTGCTCTTATAAATAGTTCCATCATCCCATTTGCTTTCTTGTTGTGTGGTATGCACTTTTTCAGGTCCATAACCTATACGAAAATTCGATTTCATTTTCCATTCTCAATTACATTTTAAAAATTTTTTAAAGCAAATCTCGCCCTGAGTCCATCGATTTTAAAATACGTTTTTTGGTTTTCAAGAAATTCCATTATGAAATTCGGTGTCTTTCAGACAATTTTGAGCCTAATTAAACAATTTAAACTTTTGACTACATCACCTTAAACTTAATGCCGTTTAAACTTATAACTTTTTCAGAATCCCATATGCTATGGAAGTATTGCACTTGCTACACCGGCTAATTCTCATGATCCTGGTCCTAATCCCATGTTTCTGGCAAGCTTACGATTATCCCCGTTCTCGATTCTCCGATTCTCTGATCTATCAAGAAATTCCGCGCAAAAGAGCTGATGATTTCAAGGGAGTTTTATGTGTGCTATAGCTTACTGACAGGATTTCAAAAAACAGTTACGGTAAGATAGTTTTTTCGAAAAATTCTTTCACGGATTTCTTGCTTCTTGCCGAACTAGGCCATTTTGGTTCGGCCATATCTGGGGTAGATTTACGGCGCGTCGCGTGTGGCATCGCGGCTCGATTTTATTAGTAACTAAACTAAAGGGATTTGTCCGTGTGGAGTACACGACTTTCCCACGCGTTGTCCGGCAGGCGATTGTCAATCATGGGGAGCGCGAAAAATTAAATGAGGAAGGCCAGAACCCCGTGCCTGTATAGGATATTTTGAATCTCGAATTTTAACGAAGATTTGATTGTTTGAGTTTGAGGTCGGAAAATAAAAAATTCCTTTACGGTAAATTTTCGGATGCAAAAATGTGATTCTGCTGTAAAAAATCCGAGAAAGCCAAGAAATGTGCGGAGCCTATTTTCCGATTTTATATTACGTGGTTGGTATTTCAAAACTTCAAAAATATCAAATTCGGAAAAAAAACCGCTACTTGGTAAAATTTCCTCGTAAAATATTCTCCGCTTACGCCGCCCCTCTCTGGGCATTTGGAAATTTTTTCGTTAAATTTGTTGGAATCTGAAATTAAGTCCAAAAAGAACCAAGAAACGGGCGGTATTATGGGATTGAGACATGGTGCATCGATATGGAAACGGCTTTTCTCAATTTGGTTTTTTTAAGGATAAGAAACTAGCAAAACTCAAGTGGCCTAGCTTTCAACTCTTCCAGAATTCCATGATACATTCAAACTGGTCATTGCTCATTGACGCTCTCTCTTTATGTCATCACCATAACGAATCCACTCAATTTTCACTCAAGCTGTCATCTCCAGCAGTGTCTCTCAATTTAATCATGCTTGAAATTGTTTTTATAAAATGAAACAACAGCGACATACTCTGTAAAAGCTATTATTAAAAAGTATATATATACACGAATTCCTGGGTGGGGATTGAGACAACGGAAGACATGGAGGAGAATTTGAATTTCATTAAAAAAAAAAGACAAAGAGGTAGGTTACTGTAGCATCCAATCTGGAAGTGGCTGCACAAAGAAGAACCTCCACCGTCAGCAATATGTTCGACACACCTGGAACGTTGAAACGGGGTATTATTTCCTTAAAATTTTCTTAGTCTAAGCCTGAGCCTAAGCCTGAGCCTAAGCCTAAGTCTAAGCCTAAGCCTAAGACTAAGGCTACCTGAACCTAACCCTAGGCCTAATCCTAAGAAAAATCCTAAGCTTGAGCCTAAGCCTAAGCCTACTAAAGCCAAAACCTAAGCCTAAGCCATAAGCCTAAAGAGCTCCCAAACCTTAGCAAAACCTAAGCCGAGCTTAAACCTGAGCCGATACCTCCTAAGCTTCCCTATGCCTATTCCTAAGCCTAAATATAAACCTAACCTAAGCCTAAGCCTACGCCAAGCGCGTCAGAGCCTAAGCTGAGCCTGAGCCTAAAATTAAGCCTCAGCCTGAGCTTGATCTTAAGCTTAAACCTAAGCCCTGAAAATTTTTTTTTGAACTCTCGCACAACAAAATTTGTAGAATGTTATGAATTTAAAAATTGAGATTCTAAAATTCCCCGCCAAAACGTTTAAAAACTTCACATAATTTATCTGTTTAAAATCTATATCCATCAACGGCCATACCTCTTAGATTTAGATTTTCGCGGCAAAACTTGTAGATCATTTCAAAAATTTACTTTCGCGCCAAAGATTGTTCGGCTCGCGAAATTTACAATTTTATAAAAAATGTATTTCACAGAATTTCAAAAAATCGAAAATCGCGCCAAAAAATCCATTTATAAAATTTTTTAAGTATTGTGACGTCATAGACTACAAACTAACCCCTCTATTGCCCCTCACCGTGCTCTCCAATGAGTTCGGCTCCACTTCATCAATCCCTGGGAACAGGCCCGGGTCCTTTTTTTCCTCGTGGGCCTTGTGCACCAATCGGGCAGTCGATACCAGGCATATCAGACGGTCCTGGCGTGCCCGAATTCTCCTCTCTCCGATCGTACCTGCCGTTGGACCCGATGGATGAACGGTTTCGTGTGGCGTCCGCACCCGGGTCGCCCATTTCTCCATCCAGTCCTTGGCCTGAGTGCCTTGTAGGCCTTTGGGTCCCATTTTTCCTAACCATTTTCCGCGAGCCGAAGTCCATTCTTTCCGGTAGTCCTGGCTTACCAGTGCTTACCCTTTCACTCCCTGAAAATTTAGTTTGGGGTATAGGCCTATCAAATAGGCTTACCGTAATCCCAGTGGTTTGTACTTCTCTCGGACACCGGATCCGCACACAAAGACTTATAATTCACAGGAGGCCCACATGGCAGGCGCGCTGGAAGTCCAGGCGCACCTTCCGATCCTCTCGTTCCAGGAAGACCGTCTCTTCCTGGGATCCCGGGGGGCTGTTCCTTGTGGATGACGGCACTCACATACTCGGTGGATCTTGCGGTTTGGCCGGTTTAGGAAATCGTCCATTTCATCTCTTTTCTGGCGGGTTATGTTTTGGAAATCGTTGGCGACAATCGCATGTTTTTCATCTCGAGGGCGCTCGGGTCTTTGGACATTTAAATTTGCTTGAAATTTTCAAACTTGTTATATTATAATTTACAAACTACTGACTTTGTATGTTTTTTTTTTATTACAGGAACACAAAATTCTAAGAATGCGTACTGCACAGTATATTTGACGTGCAAGATATCTCGTAGCAAAATCTACAGTGACTCTTAAAATGCGATGACTACAGTCGCGCTTGTGTCGATTTAGCTCGATTTTCGCAACTTTTTTTCTTTTGGATTTCCTTCGTCGTGTTGTTTTCTAACATCTTTTTCTTTCAAAATTTCAATAAAGCTTTCTATCGATAAATAAATCTTTTTACTTTATTTCGAAAATCGCCCGTAGATCGACTCAAGCGCTACCGAGTCATTTAAAGGTTCACTGTAGTTTTCGCTACGAGATATTTTACGCGTCAAACATGTTGATACGCATTCTCGAATTTTGTGTTTCTCTCCATCATACTGTGTTTTTTGGATTTGAATGGAAGGAAAAGCCCGAAACTTTTAAAATTTTTCGGTGCATTCGGTATCCAAAAAGCTGAATAAACTAATGTGTACAAAAAAATGCCACATTTTATTGAAAAGTTGATAATAAAATAATTTGTTCTAATTAATAATGTTTTGAATTTCTCAATTTTGGAATTTTTGGATTTTTTCGGGCCAGAAAGTAGGCATTCTCTGGAATGATGTTTTCTTCATAATTATATATTCAAAAAAACGGACTCCCACAAAAAAAGGTCCGAGAGGCGAACAAGGTTGTAAAACTTGCTATTGTTTATTTACAACCGCCATTAGACACCTATAGGGGTTGTAACAAGCCACATAACAATTTGATAAGATGCACACAGTAGGGAGAGAGGACCTGATTTAAAAATATAAGGAATTTTCTCATTAGATACAATTTTTCTCTATTTCTTTCACGGTGGAATATCGAGAGGAAAATCAGCGAAATTTGAAATTTTTGAGAGGTTTTTTTCTAAACAAAAAAAGATTTGAAAAATTTCAAGATATTCTGTGTATTTATCGATAAAATTTGAGAAATCAAGGGGGTCGTATAGTAGTGAGACGGTCGGTTTTTCTACTTTCAGCTAACTATATGAAATTTCATTTGTTCAGAGACGGTTTTCTGACATTTCAAATCAAATGGCATTAGCTGTTTTTCATGAAAAGTTTCAGAAAGTATCAAAGCTCGAAATGTTGGGAGGGTCGTATAGAAGGTGGACGCACTAAAAAAAAAGGAAGTGGTTCTAATTATTACGGAAACACCAAATTCTGAGAATGCGTATTGCAGTCAAAATATGCGCAAAACTTCTCGTAGCGAAGACTACAGTAATTCTTTAAAACTTTTGAAGCGATCGTGTCGACACGTGGTGCCGGGACAGATTGTCTCAATATTTCGGCTTGATCTACGTAGAACAAAAAATGCGGGAGAAGAGACGCAGACTTCTCAGCTTACTGATTTCTCATGGGGAACCTGCTGACGTTACATGTTTTCGGGCCGAAATTTCCCGCATCTTTTATGTGGGTAGATCAAACACACCGTGATGGGACATGGCAATATGTGTGTCGATTGTTGGGTTTTTGAAATTGATTAAAATAATTTAGTTATCGATATTATATTGAAATTAAACAAACAGTGAGAAAATAACTCGAGCACGTAAATCGACACTACAATAGTCATATAAGCTAGAATTACTGACCGTTAGCAATGCCACAAAATATGTTTGCGCGTCTAATATATTGCGCAGTACGCATTCACAGATCCGTCATCCAAGTCAAACTCCTGACAGTACTCGGCATCGTTGACATTGAATTCTGAATAGCCGAGTGTCGAAGTATTGAGGCAAGGGGTCTACGAAACAATGACGACATCGTGGATAGCGAGATAAATAGTGAATCTATGATTCACGTGGCGTGCTTTCTCGAGCATTCTCGTTCATTTTCCAGGAGAAGCAAGAGAAGCCTATGGAGAACGAAAAGTGAGTAAAGAGGAATGATGCGCTGGCGCGGAAAAACGAGAGCGTTTATGTATGGGAGTGACCCAAAGACACGGAAAAATAGATAACAAGAAGAACAAGGGGGCAACTTTCTCTATCTCAACATATCATCATCACCCATAAATCATTATCTCCTTTCTCCGGGATTTCATGAGAATAAATCCATTTACTCGTTTTTTTTGTGTCTTAAGTCTGCAATAAATATGTAGCTAATTTCAACTTTAAAATAAAACTTAATGAAACTAGTAATTCTATCATCTCTCAGCATACCCATTCCTTTCTTTTATATATAACTTTTATTCCACTCTGTATTTAAAGAAATTTCAAGTTTAGAGTCTAACTTGAAAATTGACAGTGATGAATATAAAATTATACGCGTAAAGAATATTTCGAGAGAAGTTGGGAGTGTAGTCTTGGAGGAGGAGAGAGGAAAGAGGTGAGGAAAAATTACGTTTTTTTGAAGTTTTTTCTTTAATTGTTCGAAGGATTAGGCTTAGGCTTGGGCTTAAGTTAGGCTTAGGCTTAGGAATAGGCTTAGGCTTAGGTTCAGGCTTAGACTTAGGCTCAGGCCAATTTAAGCTCAGGCTTTTGTTCAGGCTTAGGTTTAGGCTTAGGCTTAGGCTTAAGCTTATGCTTAGGAAGAAGGGTATAGGCGGCCTAGGCTTAGACGTGCACAGGCGTACATTGGCTTAGGCTTAGGCTTAGGCTTAATCATTAGGCTTAGCATTAGTGCTTAAGGCTCAGGCTGAGGCGTAGGCTTAGACCAAGGCGTAGGCTTAAGCTTAATCTAAGGCTTAGGTGTCGACTTAGGCTTTAGGCTTAGGCTTAGTCTTAGGCTTAGGTTACTCTTAGGCTTAGGATCTCAGGCTTAACGTAGGCTGCGGCCTGGGTGAGGTTTCGGCTTAGGTATAGACTTAGACTAAAGACTTAGGTTTCCTAGAATCAGACTAAGGCTTAGGGCTTAGGCTTGGGAGGCGCTACCGAGGCTGGGCGGATCAGAAAAAGAGACCAAAATTCCAGGGAAATCCAAATAAAATCCAGAGAAAATAATAAAAAAAAGGAAACAAAAAACGTGAAAAATGGGCATTCCGCGTCTTCCGCGTCAAAACCCGTTTTCCTTAAAAAACGGACAGAGGAAAGGACCAAATTATGAAATACCAAAGTTTAACAAAAAATATTTAAACATTTTTTTTGCCGGGGTTGAGCTCACCCAGCTGAGCTCACTCCATAATTGCACACAAAGTGATTCTCAAAAAATTAATTTTAGAGACTACGAGGCTAGCAAATGGAATGCACATGCTCTGATTTCTCAGAGCGGAAATGCCCGCCAGGCTCCAAAGAGCGTGTGCTCCAGGAGCCGATGGTCCTGAATCCCCGGCTCCAGAGGTCTGAATGGTATGGATGGAGAGGCTGGGCACAGTAATATGGCTGGTATGTTCACTGTAAGTTGCCCAAGATCTTTTTTGTAAATTCATACTCCAGTCATGAACAGGATGCATCCGTTGCCTAGCGGGTCCTCCAGGTTCTCGCCTGGTGATCATGGATCTCCTGGTAGGGTACCCCGGGTCAGGACCTCCAGGGGAACCCGGTTACGCAACAATTGGGCTTATCGGGCCACCTGGGAGCGACTCGCAGGCCAAGATGGTCTAGATGGAGCTCCTGGCGAGATAGCCGCAGTGGAATGGATGCAGGGGAGATTGTTTCAGTTGATGGAAAAATTGGAAGAAGAGGAGAAGCGGGGAACAAAGGAAGCAAAGGATCTCGAGGAGGGGTTGGAAAAGCTGGAGGGCCTGGGGTGGCTGGAGAAATGCGAGAAAAAGGAGTAAGAGGTGAAGATGGAAAGCCTGGAGAGTCTGGAAAGGTGAATTTTCAGAAGTTGATCGATGCACCAGGGAAATTAACGCGGTTTTGCCGATTTGGCCGGAAACTGTCAATTCCGGCAATTCGCCGGTTTGCCGATTTGTTGGATCTCAAATTTGGCGGAAATGTTTAGAGGGGTTTTTTAAAAGACGAAAACACTTAAAACTTTATCCCCTTTTTTCCCGTTTACTAGGGAATATAGTTAATAGGGGAATTGCTAGGAAGAAAATACAAACTTTAAATGACTGATGAGGTCTTCTGGCTACAAAAATCATTTTTTTCATTATTATCATTTTCATAGAATTTGCTCTCTTCAAAATAGACGTAGGGACATACATAGGATGCTTAATTTCGCCGTTTGAAATTTACATTCTGAATTATCCAAAAAAAATCGGCAATCTGCGGTTTGTTGCCGGAAATTTTCCATTCTGGCAATTTGCCGATTTGTGCCCGATTTGCCGATTTGATGACCGGAGTTAACTTTCAATTCCTGCAATTTGCCGCCGTTCAATTTGCCGATTTTCCGGAAATTTTAATTCCGGCAATTTGCTGATTGGCCGTTTGCCGGAAAATTCAATTGCAATTTGCCGGTTTGCCGATTTGCCGGAAATTCAATTCCGGCAATGGTGTTGGGTTTGCCGATTTGCCAAAAATTTTGGAATTCCGGCAATTTGCCGGTTTACCGGCCAAATTTTCCAATTCACCGGCAATTTATTGATTTGCCGATTTGCCGGAAATTTCAATTCCGGAAATGTGCCGATTTGACGGAAATCTAAAACATTCTCCGGCCGAATTTTCCAAAAGTATAATTTTTAAGCCCGGCGCACCTGGAATCCCTAGAAGTAACTGCCGATGTCCCCAGTAAATCGTCACGATATTTCTCCATATAGAATGATGGAAAATCTGATAATAGTAATAAAGATAATAATAAAATAAATACAGGCAGGAAACGAAAAGCGAGCACTGACGATTGTATGATACCCGAAACATTCAGGAGGAGCACAAAAAACACAATGAAAAGACACAGCTCAGAAAAATTGAAATTGAAAAACTGGTAACGAGACTAGAATCGTCATGATGATCTTGTAGAAAAAATTGGAAAAAAATTAAGAATCTAGGAAATTGATTAGGTTGCACGCAGACTTGACACGAGCTCGGGCACCGAATCCGCATAGGCCAATGTTTTCGCATGCTCTTGAGCCCATGACGGGCAGAGGGAGTCATGATCGATGCATCTGAAATGGGGATATTATTTTTTACGCTTCAGGTTTAGGCCTATCGACCCCCGTTTGGATCTCCGGCTCAGGTCCTTAAATTGTGTATTCAAGCGTAGGCTCTCTCGCTCCAGCCTTTAGATTTTAACTTCGATCTTAGCCTTACACTAAGCTCTACGACTGATCTAGGATATCATACTAAGGGCCACTTTGGGCCTGAGGCATAGGCTAGTATCTCAAGCTTAGGATCTCACGCTTAAGCTCTCTGACGCAGGCCCATAGATTGCAATGTAAACCTTGGCCTTAGCCCCGACTGATTTAGGATATCAGACTTAGGGCCTAGGAGTTCCGGCCTGAAGCTTAGGCTCTCAGATTCAGGCCCTCAGACTTAGAGTCTAAGGCCGTTAGACTACGATTTTCAAGCTTACAATTAGGCTTTCACTTGAAATCAAAATCCAATTAAGTTCTTTAAAAATAATCAAACATTTCTAAACCGCATACAATTTTTTAAAAACTACCCTAAATATTTCAAATTTTAGAGGTTAGCCTGGACTTAAACCTTTAAACTTTTGGTCTCAAATTTAGCCTACAGGTCTGTGGACCTAAGATTTTGGACCTCGGACTGCGGCCCTTAAATCTCATGCTTGGGCTCTAATGTCCTGGCACGCTAAGTCCTAAATCTTTTGATCGTAGTTTCAGGCTTTCATGCTTTCAGGCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTGAGGCTTTCAGGCTTTCAGGCTTTCAGGGTTTCAGGCTTTCAGGCTGTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCATTCAGGCTTTCTGGCTTTCAAGAGGCTTTCAGGCTTACAGGCTTTCAGTTTCAGGCTTTCAATCTTTCAGGCTTTCAAAGGTTTTCAGGCTTTTATGTTTCAGGCTTTCAGGTTCAGGCTTTCAGGCTTCTTTATAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCTGGCTTTCAGGCTTTCAGGCTTTGAAATACTTTCAGGCTTTCAGGCTTTCGGACTTACCGGCTTTCAGGCTTTCAGGCTTCCAGGCTTTCAGACTCAGCTTTCAGGCTTTCGGGTTGTCAGGCTTTCAGGCTTTCAAGCTTGGCTTTCAGGCTTTCAGGCTTTCAGGCGGGCTTTCAGTCAAACTTTCAGGACTTTCAAACTTTCAGGCTTTCAGGCCTCACTGTTTCAGGTTTCAGGCTGCTTTCAGGATTTGAGACCACAACTAGACCGGCAACACAAGTGTTGTCAAATTACTCACCTCTTTGCCGGCGCTTTATCCGATGCATATTTGATGGTATCTCGATTGTCTTTGAAGCTTTTCAACCCGCCCCAAGTTTCCAGCTGTTGGAATGATCGTTGTAACATCAAAAATCATCATCAAAAATCGTGGTGACCCAAAATTACCTGATTCTCAGCCAAGAATCCATCCAAACTTGCTCTACTCAACTCGGAGACAGGAATGAAGTACTTGACGTGGGCTTTTCCCTTTGCCCAATCTTCTGAGCCACCGGATGCGGGGTCTGGAAATATTTTGAAATTTTCTCACATACATAGGAGCCTTAAGAAATAAGCGCTTACAAAGTGTATCTGCACCGGTTCCAACTTTGTACTGCGTGTTGAAGACACTATAAGCCTGAGCTGACTGAGAGGGCAGTGGATCTCTGAAATATTCAGTAAAATATGACCATGAACTTGGGCAATTCCCGTATTTTTGTAGATGACACCGTAATGGCTAAACACGGGGTGCCAGAGTGTCGCGTTTTGATCTACGTAGATCTGCAAAAAATGCGGGAACTGATTTCTCATCGGTTAAGAACGTGCTGACAAATTATATTGAGCGAAAAATTCCCGCATTTTTTTGTTAAGATCAAACCGTAATGGGACAGCCAGGTACCAACTAAAAAATTTACTCCAACCAAATCATTTTTCAAATCATTGGAATAAGTTCTGTTGATGGCCGAACGGATACATCAAAATTTGACTGAGAGTCCGAGTGGAAGGTGAGGAATGTCGAAATACGGTGTCGCTGCACGAAATCTCACCGCCGCAGTCTCGGGCAATATCCGAGAAGGCTGGTTTAGAGGCTCCCTGATAGATTTCCGAGGAAGGATTGATGAGCCGACTTGTCCGTAGAACCAGTCAAAGTTTCGACTGAGGTCGACACCTTCAAAGACAGCGGGTTGTTGAGGGAGGTTGGGAGAGTCCTGAAAGGTTCTTATTTTTGAGATTTTTAACGTTCACAGTCGGAGAATTGCCGCAAAATCTTAGTTTTCATAGCCTGTGTGACATTATTAGGGCGTATCTAAAGTCCAGAAAGCGTATGCCTTGTGCTGTTTTTGCAAAAATTGTGCCCAGTTTTCCCACTTTTTAGTGGTTTTTGATGGGTTAAACCTAAATTTTCTGAATTCAAGTTTTTACTTTTTCCAACTGTTTTTTCAGCCGTCGAATGGCTGTCCTTTTTTTTGGGCAGACAAAAAAATAATCTTTCTGAATAAGCTAATCGAAAACAATTATAAAAAAGGCAATTTTGTAAATTTTTTCTAGTAAATTTTGAGTCCTCTACAAAATAAACTATTTTGGACGAGTTTCAAAAATGTGAAACATTTCTACAAAAATTGCCCAATTTTTGCCCTTTCTGGTGGTTTTTGATGGGTTAAACCTAGATTTTCTGAATTCTGCGTATATAAATTACACGAACAAATTTAGACATTTTTTTTATTTTTAATTTTTTTCCAGCCATCTAATGATGATTAGTTTTTAACAAAAAAAATTTCTGAAACACAATTATTATAAAACAGGGGTGTGCGGCAAATCTCAAAATTTGCCGAGCACGGCGAATTTGGCAAACGGCAAATTTGGCAATCAGCTAATTTGTTGAGCTTTACAATTCCGCAAAAATTTGATACTTAATTTGAACCACCTAAACTACTAATTTCTGAACAAAACGTGTTCAATAACTTGATTTTGTGCCATTTTTCTAAATTTTTGGAAACCAATAATTTTGACAATAATTTTTGAGGCTAAACTTGTATTGTCAAATTTTTGACGCGGGCGGCAATATTTCAAAAATTTCTGAGCTCGGCAAACAGCAAAATCGGCAAATTTGTCAAATTTGCCCCACATTTTTTTTTGGTTCATAATAAAACACTAACATTTTAGATTTTTCATAATTTCCCGTCGAAGGTTTAGCAATTGCTAAAATTCTGAAAAATCTGAGTATTTTAGGAAACCCAAAGCAATGCGGCATGTTCCGACCCCAATGTATTAATACAAATGATTAAAACAAACGAAATTACAGTAGACAAAATGTAGAAAAAAAATTATTTTTGGTCGACTCCAAACGAATTATGAGTGGCAAAAACTTTGTAATAGTCACCTTTTGACAGTAAATAAATTAGAATTTTTTTGAAAAGTTTTATTATGATATTCGGTCATTGTGGGACCAAATGAGTGGTTTTTAACTATTCCGGCACTGGCGCAGTCCAGCATTTGCCGTAATCTTAGTTTACATAGCCGACATATGCGGGCCTAACTGAAGCCCAGGAAGCTTGTTTACAAAAATGAGCAAGCAGAAAAAGATCAATCTCCCCAACAAACCTCTTGCCTGTTTATTACACTTTGGTGGTGAGCGATTCTTTCTCCATAGTCTGATCTCCGGATGTACATAGCTACTTCTACTGTACTCATAAGCATCCGGATTCAGCAGTGGAACAATATTCCATTCGAGTTGATCTACGAATTGCATGATTTGAACATTTGTCGTACTGGGTGACCAGTTGGTGAATGAAATAGAGTACTGTCGATTGTGACACCCATTCACGAGCATGGATTCCTCCGTCCACCCAGATGCCACGTTTCGTACGTTACGCTTGTTGGTGATCTGGAAGTGAGGAAAATTGGGGTGAGATGGGATCACTAAATTGTTAATAGTTTCTGTGCTTCTGTGTTTATGTTTTTTGCGCTCCATTGGCAAGAAATCGCCTGCCCATCAAAAACCGTCAAAAAGTGGCAAAGCGGGGCAACTTTAAATTCCCAATTTTGAAACTCCTCTAAAATGGTTTAGTTCGTAGATAGAGAGGACTTAAAACTGATTTTTCTATAAATTGTCTAAATTTGTATTGAAAACGGGTAATTCTTGTATATCAGAAAATGGTTTAACCCATCAAAAACCATCAAAAAGTGGCAATAGTGTTCTCGGCCATTTTTGCGTGATAAAAATTCACAATTTTGAAACTCCTCTAAAATGGGCTATTTTGTAACTACTCAACATTTCCAAACTCTAAAGAATTGTTCAGAATATAGTGGTTTCAATAATTTTCGAACAGAATGTTTTTTGCCCAAAAAAGGATGGCTGAACAAAAGGCCGAAAGAAAAAGAGTTTTACACTGAAAGCAAAATCGTGACGCGACACGAAAGCTAGGTAAATCGACCCCAGCCGTTCCAGGCCGAGTTCAAATTGCCAAATTCGGCAAACTCTCACATTTCAGGCTATGTATTTCAAGCGAGAAGCGCGTGCGATTTCTCAAAAACCGGCAACTCAGTTGGGAGGACTTTACGAAAAAAAATTCCAAGGTATAATTGGTAGGTTTAGTCATGTTGCATGGTACTTAAAATGTTTTTTTAACTTGCAAAAGTGGCTTTTATTTTGCTTCTTAGTTTTGCAAGCCGAATAATAAAAATATTATCCACGTTTTTAATGCTTCCATGGTAGGCAGCCGCTCGCCAACATGGAAGCCCTACATGTCACGGATTTTTCGCCAGAAATTGAAATGTGGAATGAGCTATGCCGTACGAGGCCAGGCCATATCTGTGGTAGATTTACGGCGCGTTGCATGTCGCGTCGAGGCTCGATTTTAGTTGAACAACTAAATGCATTGTCCGAGTGGAGTACACGACTTTCTCACGCGGGCGATTGCCAATGGCGCGCGAAAAATTGAATAAGAGGAGGGCCAGAATCCCGTGATCCCGTCCAAGCAAAGTTAAAACAACAAGCAAACCTTAATCAACGGGATCTGCCGTCCTTCGTGAGTCGAAGTTCCGATTGGCTGCAGACACATCCGGATATGGTTAATGACGTTCAGGTAGTTGATAACATCATCAAACGATTGGTGATAGGCGTTGTGCAAGGTTAAATTGAACCTGCAATTATTGAACTATTATCATTGAGGAGAACGTGGTGTCTGGGTGCCTCATTTTAGATTGATCGCTGATCGACAAAATGCGGGTGAAGAGAATGATTTCGAATGGTTAAAAACGTGCTGACGTCACATCTTATGGGCTGAAAATTCCAACGCATTTTTTGTAGCTCAAACCCTAATGTGACAGCCTGACACCACATGTATTCACTCACTTTCTGCGGCTCCCTCCAATCATGCAGTCGAACTTGATTCCGAAGCTAATCCCGCTTCCTTCTGCTCGACAATCACTGTGAAATGATCGATGAAAAGATAAGTTGGGCTTAATAGTGTCCCCCCACGAATACACTCATCACGCGTAACGAGCCGTGATGCGCGGTGGTTTGAATAAAGAGTATTTGGACTAGTGATCCCCCGCGAAAACCTGTATCGCGACTACGTGATGCCAGGGTGTCTCATCACGCGGGTTGATCTACAAAAAAAGCGGGAATTTTTTGCCCAAAAATGTGACGTCAGCACGTTCTTAACCCTGGAGCACCGAATTGAAGCAGTTCCCGCATTTTTTGTAGATCTACGTAGATAAGCCGAGATGACACACTCTAACACCACGTGGTATGCGCCGAAAAACTCACTTCTGAACGGCACCAATCATCGTTAACGGAATGCTTAATCGAAGGATCATCGAGCTCTTTCATAAACTGCCGTGTTTTCTCATCGGATATCATCACATGAAACTCCTTGCAAGCTAAGCTCCGACGGGGATTTCCAAAAATCTAGCGGAAAATTTTAGTGTGTCCGGAGGCACCCTAGTATACTTATATTTCAAAATTTTTCTCTAACCCCTCAAAACCGTACTCTACATCGCCGTACTGGCCGAGTGGTCTAACGTTCAGGTCGCAGTCTCCGGAGGGCGCAGGTTCGAATCCTGCGGACGGCAGATTTCTTTTTAAATACTACTCTTCAATGCATGATGAAGAAGAAGAAGAAAAAGAAAGAACGTATTGGCTTTTACTTTTACACTTTTGATAATCCCTAGGAACAGGTTATAAACAGCGATGCAACATGAAAAGCAGCAGTGAGTGAGATGGACAACGAGCTGATTTTGTTCTTCAATTATATGACACCGCTATTTTAATGGTTGGTTTGTTGCGTGGAACATCATACCTTTAAATGGTTGAATTACAAATCATGTAATAATAATGTCTACTTGATTATCTTGGGTCGTCGGCTGCACCATCCATACTGTGAATTTTCTGAAGAATCTTTCTGAGAGTTTACCGGCTGTTGGGGGAGAGTTTACGATTAACGTTTGAGTTTTTGGATAGATCTAAATCTAGAGAAGATCATGCGGCGGTTAGGTATATTTGAAATAAAAAACAATTGACCTAGATATGAAACATGGAGATCTAATGGATTTGGTAAAGTTGAAATTATTATTTTTTTGAAAATTTGTTCATTTTACAAGAAAAGACGAATAAATATTGACCAAAAAAATTTTTTTCAATCAAAAATGTATAAAAATTAATCATCGTTCCTTTTAGCTTTTAAACAGCGGTGGAGTAGCCAGTGTGGATTTTGTCTCCCTAAATACAGTCAATTATTATGAACCAAAATTCAAATATCGTGTAATACAACACTTCAAAAAACTTCTTTATTTCAGATTTTTCATAATTTCTGGCCAGACTTTTTGCAAATTTCCAAAATTTTTCAGAATGTCGAAGTTTCCGACCCCTGCAATGTTTTAATAGAAATGATTGAAACAAAATTACAGAATAAAAAATGTAGAAGATAACTTTTTTTTTTTGGTCGACTTCCAAAATTATGAGTGGCAAGAACTGTGCAATTGACACTTTTGTGAAAATAAAAAATTTTAAGAATGTTTTTGAAAAGTTGTATTATGATATCTGCCTCGGTCAGTTTGGGACCAAATATGAGTGGTTTTTAATAATATTCAGAAGCCACTGGCGCTACTCCCCGTTTAAAGTTCTATGGTTTTTAAAACTCACGTTTTTTTTTATGAAGTCTATTTTAAATCTGGACTCTCAGTCGACAGAGGTTCAGCATTTTTCGAAATTTCAGAAATTTAAAACATAAGTCGGGTCCTAAAAGCTACAAAAAAATTCTCACAAAATGTTTTTTTGATGAAAGCAAACTTATATAGGAGTGCCAAAATGACCAAATTTTGGTTTTAAAAATGATATTGAAAAATCTTTAGAAAGTCTCTTCTGGTTTTTATTTATTTTTAAAAAATTCATATTGAAATATTATAGTGCTTTAGATTGCTCGGAAAAAATTCCACACATTTTTTAATTTTTCATTAGTTTTATAATGATATTTGGTCATTTTAGCTATCTCGGGTAATACTGCAAAGCCACGTGGTGCCAGGATTTCCCATTAAGGATTGATCTACAAAAATGCGGGACTTTTATTCCGCTTAAAAAGACGACGTCAGCTCATTTTTAACCATGCGAAATCAGTTGAAAACTGTGCCGCAATGATTTTTTGTAGATCTAAGTGGGGAGATCAAACCGAAATGGTGAGACATACTGGCATCGTGTCCACCTTCATAGTTAGTAATTGCATAAACAAAAAATACTGAGAATGCGTATTGCACAACGTATTTGACCGAACGCGCAAGAATATCTTGCGTTGCGAAAACTACAGTAATTCATTTACTACTGTAGGTTGGTTTGCCACGCAGGCTGGATTTTTTGAAAAATAAATGAATTAAAATAGTTAATGGAATATTACTATCTCTATGTATTAGTAAATAAGGTTGAACCCGTAATGAGACCGCTGCCTACCTGCCTGATTATAGATGGCCGCCCTAAAATTAGGCAGGTAGGTTTTAACGCCTAGCCAGATACAAAACTTAAAGAGAAATGCCTAAAATAACAATAACTTACATCCTTTCTTATCGTCCTCCCCGGCGATCGCCTAAGATCATAGCTAACAACTAGCCGCTTTCGGTCATGCAATTATTATATTATAATTGATGGATGGATGGGGGATAATCCAGAGAAAGGGGTGAAAAAAGAAACATACCTAGAAAACAGGTTCCCCTGACTCAAAACCTACTTTTGATGTGCCACCACGGATGGCACGACGAGATACGATGATCACGTGTTCATCTTCATCATTTTCATCGTAGTAAAACTTGGGGGGGCTGATGTGGGAAGGATGCCCTCGTCAAGTGTTCGTTGAACAATCCGACACGGTTATCAAAAAAGCAGTGGTGTCTCCGCCCAACTTCCGCGCGTCAGCCGCCCTGTGTACTGTCTTGTCCTATAGCTCTCTTTTCTCCACCCCGGCTTGCGGGTGAGATTGTTCTCATTACTAGGTGAAGAACGTCTCTAGTAGAAGAAGAAGAAGAAGAAGACGACGATGGAGAAGAAGCTGAAGGCACGACGCACTGTTTGCGCCACGATGTTTGTTGTGTTTGCGAGCGTGAGCGCCGCAATTAAAACGTGTAGATCGGTTTGAAAAGCGCGCGCGCGCGGTCATCTTTCTCCGCTTGCGCGCACGCATTGACAAAAGACCGAGACAAAAGGTTCAAAATTGAAGAGGCAAACGTTCGTCCTCTTAGCACCTAAATGTGGAAGCATAAGATTTTGCTCTGAAAATGAAGTTGGGTAAGCTATTCCTGGGTGATGTTCTCAAATTCCGGGGGCATTGTTGGGAAAGTGAGGACCAAAATAGGCCATAAAAAATGCAGATATACATGCTAAGGCTTTGGGGGCTTAGGCGCAGATTCAGGCTTAGGCTTAGGCTTAGGCTTAGGCTTGGAATTAGGCTTGGCGTCAGTGGCGAGCGTGAGCTCGCCACGGACGCTATTTAATTGGGTTTATAACGTTTTTTTTTCGAGTTCCCGTCGAGCGAAATTCAACTGAGAGTCGTATAGGCCGCCGAGAACCTGACGTTCCAAATAGGTGACTTCATTAAAACTCTTAGGCTTAGGCTTAGGCTGTCACTAGGCTTAGGCTTTTAGCCATGCTAGCTGATCCCGAACATATTTTTAAAAATTGCAATATGTGACCAAAAGCTGTATTTTTCAAAAATCCAAAAGTACGCGAAATCATATGAAGTGCTTCTTTTTCTTTCAATAAACTGTTCAGAATTGTCATTTTTACTAGAAAATACCACAAAAATATGCTAGCTTGACCGGAACATATTTGAAAAAATTAGAATTTTTGACCAAAAGCTGTTTTTTCAACAAGTTGAAAAGAACTGGAAAATCATATGCTTCTTTTTTCTTACGTAAAACTGTTCAGAATTGTCATTTATACCAGAATATATTAAACAAAGTATGCTACCTAATCCGAAACATTTGTTTCCAAAATATTTTAAAAAAAAGATTTAGCGGCTCTGACTAAATTGTTTGTTCGTTTTTTCTGGTTTTTCCACTTTTTCGGTGAAAAATTTTGTAAAAAATTTGACCGAGGTGCGTGTTAGAGTTGAATTCATCAAGTTTTGACATTATTTTAGTACGGGCACAGTTGCTGCAAACGAAATTTCCAATAACGCTTATTTCTCGGGATAAAGTTATTCTATTTTTCTTTGCAAATCTGCTAATTCTACAAATCTACTAACCGAGGTGGAGTTGAACACCTTTCCAAAAAGAAGTAGCAGTCCTGAAAATGTTTTAGTGAGGCTTCTCATTATTCTAGAGCCCGAGCCACTAATGTAATTGTTCCAGAAGTAGTTTATAAATTTTTGAACTGATTTTATCCTCTCCATGATAGAGGAATTGTTAAAATTTTCAGATCAAATTGGAATTTTCACAGCCAAATATTTTGGTAAATTTTCCACAAAAAATTGGGCGGAAATTGGAATATTAATTTGATTTAATTCGATTGGAGCAGAGTGTATAATTATTCAAAGTTTCCTCCCTTAACAGCCATTCAAACGCATTCGGCTTTTTTCTTAGTTTAGTTTTTCTTATATATGGCCTGCAGGCTCTCACCAAGTTCCGTTTTACCGGAGAGTTTAAGTGCACAACAAATCCTGAGATCCCATGTTGTAGTTTGTGAAGACGATGAGGTGTTTGAGTAGAAAAATGAGAAATGTTCTAGTATTTAAATATTATAAATTGTTTCAGCGAGAACGTTATCAGTAAACACCATTACGTGTTCCATACATATGCACCACATATGTCGCTATCTCGTTAAGGCTGAAGATACCAATGACGGATTGCCAAAGTTTTTGGATGTATTACTTTTTTTCCGTTTTCTCTAGTATTTCTCAGAAAATTTGAATTTCCCGGTCACCAAAATTTTCCGAAAATTTGAATTTCCCACCAAAATTTTTTATCAGAAGATTTGAATTTCCCACCAAAAGTTTTTCAGAATTCAAAAAATATGAATTTCCCACCAAATTTTCATTTTTTCTCAGAAAACTTGACCGCCAAAGACTTTTATCTGTCTCAGAATTTTGAATTTCCCGCTAAAAAATGTTTCTTAGATTAAAAGTCCCGCTAAGTAAAAAATTTTCGTGAAGAAAACTAAAAACCCCCGCCAAAACTTTTTCTCACGTAGGAGTTTGCATTTGCCGCCAAGAAGTTGTTTTCCATAAAATCTGATATGAAATTCCCACCCAAATTTTTTCTCAGAAAATTTGAAATTCCCGCTAAAAAATTTTTCTTCAGAAAATTTGAATTAGTCCCGCCAAAAAATTTTTTTCTCATAAAAATTTCGCTAAGCCACCAAATTTCGCAGAAAAAATACCCGCCACAAAAAGTGAACATTCTAGGAGTTTAGACTGACAGTTTACCGAAAAACCTTGACTGACGATTTTGGAAGATCGAATAACCTCTTAAATAAAACCTCTAACTCGTAAAAATTGAAAATTTAAATATATAGCTTTGCAGTCCTATTTAGACGTGTTATACATGATATCGTCCACGATTGCACGGAGAATGGGAAATATAAGTTGTTGAGTTGACTTGGGATCTTATTATATCAAGGATGGGTTAGGTACTTTAGGGCAGGCTAGCAAATGGCTTCCACGTGAAGCAGAAGCGGTTTGCCGGCTTCTCGCCTGATTCCTGCACTTTGGCAAAAATTCCAAGCCTCGATGCTCACACATAGGGCTGGCTTGGACGTCGCGTCGGTTTTTGGCAAATTTTAAATCTTTCCGAGATAGTTTTTTTTGTACGGCGACGTCCGACAATTTCCGAGTTTGGCCACTCATGATTATATTGGATTAAGTATAGTGCCCCGAGTGGCCAAACTCGGAAGTTGTCGGCCGCCGTAAAATAAACTACCTCTCGGAAAATTTTAACATTTCAAAAAACCGGACGACCGGACGCCATATGTCAGCCCTACTCACACCAAATAGTACGGTCTATAAGCGGTTTTTTTGCCGCAGGCCGACACTTTATGGTTTCCACGCCGCACTGTACAGAAGGCGCGGCCCGAGGCAGTTGTCAGGCGTTTTAGCGCCTGTGTGCAAGCTCTAGGGCAGGCATGTTTTCAAAAAAATGAACATTTTCAGGCAGTACGATGAAACCCGCAACCTTGATCTGAACACTGCCGGTGGGACGAATGGACATACGAAGTATCGGAAGAAAGGCGATAGTGATGTCCAACATATTTATTTGCAATGTTTGATAATAATGTTCATCAATATTCGAGCCTACGTAGGCTTACCTGCCTACAAAGTAGCCTACATATATTATTTTTGCTAATTAACAAAAATAATTAAAACATTATTAAGATTTGCTGAAAAAGCAAAAAGTGTTTTTAAGTTCGACTTTTTGCCCAACAGGTTTACGTTAGGCATGTGACAAAGCCTACATTCAAGGTAATCTACGCCTGCCTCGGTACATGGTGCATCGACCAATACTTACCTCTTAGCTTCGAGAGGTTATAACACGGTTACATTTCGCTCTATCAAAATAAGTGGCCAACTGCAAAAACTGTTCTCCAATGCTTTTTCTACAATTTTGTGGTTAAAATTTTTTTAATATCTACACTAGCAAATATAAGCCACCAACCCGTACAATCCGCGCCGCCCCCCGAGAAAGCAATTCAAACCCAAGTTTATTGCAATAAAAACAACACAGTAGAAACGAAAGAAATGAGGTTGATTTTGGAGACTTTTCAGTTGGCACGGGTTTTACATTGTTGGCATTATTCAGATTCGATTGAGAAGGAGAAGTCGTGGGGAGGCTGAAAAGTTCTAAAGTTGTTGAAAAAAGTAACAAATCTGCACTTTTTTAAAAACCTGATTCTTCAAGACTTCCATCCATGGCCATAAGTGCACTGAACAGTCTGTTGCTCTTGCTCTTTGTGCTCCGTGTCCTCGGAGCAATCATCAACCTTGTCTGGAACTGTCGGTGTTGGTCAGTTGACGAAGCCAAGGAGGAGGATGGTGTCGCAGTCTTTGGTTTGGGAGATGAGGGCGGAGCTGGCTGAATAGCGGTGGAATTGGAGATGCAATCTTTTTGGGGTTACTGCAGACTGTTTGCTCAAACTCTTGCTCCGCGATTTTGTGCTCTTTTTTGGTTTCTTCTTTGAGGGCTGGTTGTGTTGCTTCTTGCTTTTATCTGAAAATTAGAGTTTCTAGGCAATCAAGCGATTTTCTAGGCGACCAGACATATATTTAGCCATGTCGGAATTTTCTAGGCCAACACAAATAGTTCTAGGCCATATAATTTTCCTAGGCCACGTAAAACTTTTCTAGGAGACCACCAACAGTTTTCTATGACCGCAATTTTTGCTAGGCCACCAACAAAAGCAAATGAACATAAGACATAGGCCACCAACAGAATTTCAAATTTTTCTAGGCCTTTAACTCACATATTTCACAATGGAAGCGGCGGCGAACACGATGAAGGGTACAATGAGAATGCCAATGATTATGCATTATCACTACTTTGGTCCTGGCGTAGTCGATGTCGCATGCTGCAAAAATGGAGGTACAGGAAATCAACATGCAAACGCGCTACCGTGGCACTAGCAGTGCGGTAGAGCGCGTTTCAAACTAACAGCCAGAAGTTGGCGCCGGTGCTCGCTGAGTGGAGGTGGCCATTTTATCGGAAATGAATGAGAAAATGGAGAAATTTGGGAAAGTTGATTAGAGACGTGGGAGTTTTTTGAATTTTTATAATATTTATGAGTAGGGGGAAGGGGTGAGGGTCACAGCAGGAAAAGACCAAAAATTTGTGATTTTTCCATTAAATTGGAGGAAAATTGACACCATACCTCGTGGCCTAGAAACTGCAGAATTTCTAGGCCACACACGTTTCGTCATAATTTACCTGTTAAACCAGGTAAACTATCAAATAAAGAGTGATTAATCATCTCCTATCTTCTTTTATTGCTCAGTTCCTACTCCAAATGTTTTCTTTTTTGTAATTTGTGATCACAAATTGTTGCATTTTAGTACGCCATGTACGTCTGTGTACTACTTTTTTCTGAAAGAAAAAATGTTCGCTTTCAAGAAAAAATAGTGAGAGGTACAACCGAAAAATACGGGGGACTAGAAATATGTGAATAAGAGTTCGACAACCTAGGCCGGTAGGCAGGCAGGCGAGTAGGCAGTTAGGCAGGTAAGCAGGTAGGTAGGCAGGATAGTAGGCAGGCATAATAACGTTCAGATGCAGGCACGTAGGCGGATGTTTCGAGCAGGCATGAAAAGTCCCGGGGGTAGGATGTGGGTATGTAAGCAGATGTCGGTATGTTGACAGTCATGCTGAAGGCACGTGGGTAGGTAGGCAACTAGGCTGAGGGAGTAGACGGTCGGGTAGGCAGGCGTGAGGCAGACGCGTAGTAAGAGTAAGCCAGGTTGCAGGCACGTAGGCAGATGTAGGATGCGTATGTTTCTTGTAGGCATGCTGAAGTCATGTGGGTCGGCAGATTGGTAGATGTAGTACGCAGAGTAGGTATGTTGCGGGTATTATGAAGGCACGTGAGTGGGTAAGAGCAGAAACCGCAGGTAAGGCAGGCAGGTAGGTAGACATGTAAATATGACAGGCATATACGGAGGGAGAACAAGCCATAATTCAGGGTGGCACTTAGGCAGATTTAGGTATGTTGTAGGCATGATGACGTAACGTGGGTAGCAGAGAGGCACGTAGGCAGGCTCGTTAGCTGGCAGGCATAATAAAGACACATAAGCAGGCATGTAAATCTGCGGCAGATACGTAGGATCACAAGAGCAAGATGTAACTGGTAGGCACGTAGGCAGGTGTAGGTATGTTACAGCCATGACGGTGGGTATGCAGGTAGGTAGGCAGCCAGGCAGGATAGGTGGGTGCATAAAAGACAGGTAGGCTCTCGGGTAGACAAGCATGTAAAGGTGCAGGCAGATACGTAGTAAGAGCAAGCTAGGATGCAGGCCCGTAGGCAGATGTAGGCATGTTGCAGGCATGATGAAGGCACGTGAGTTGGTATGTAATCGGTGAGTAGGCAGGCATGCAGGCACATAGGCAGATGTAGGTATGATTAGGCAGGCAGGTAGGAAGACTCAATGCAGCCGTGGTGCTAGAGCGCCCCTTCCTAGTTAAGACAATCTCGTTATTCTAATAATAAGCTATTCAATCATGTCACCGCGCCGCATACACAAACTACCTGTTTTTTTGAGTATGAGTCTCGCCCGTTCTCTGACCAAAAGCTTCTACAGAGTGATTACACAGTATAAGGGGTAGAGAGGTTAGATTCAATCATGTCTCACTTTTTTCCCTTTCTCTGATTCTTCCTTCTCCCTTTTTTTACAGGGCGCTTTTCCCTTTTTCGTGCGTGAATATGAAGAGAGAGAGTGCATACAGGTGTAGAGGACGCCCAGACATCGAGACGGAAACAGGTTCTTCATCGTCTTCAGTTATTTGGAAGCAGGAGTAAAAGGTGACGGTGTGTGTTTGGAGACGTGTAACCATCATGTTTTATAACACTTCCTTGCTCATTTTTCTCTGCTTCTCTGCCGTCTCTCTATACACACAGTCTTTCGCCGTTTATTTATTACCCAATCACAGACGGATCAGCTATACAGAGGTTATACAAAAAGCGACGGCGGATACCCTCATGATGTGAGTTTTGTTTTCGCTTTTGCAGCAGATACAATTTCTAGGCCACCAAAAATTTTTCTAGGCCGTTGAAAAAATCACTATTTCTAGGGACGTTCACAATTTTGAGCAAGTTCTAGGTTGATGAATTAGATTATTACGCCATGGTGCATATTTCTAGGCCATCAGGAAATTTTGCAGGCCACCGTTTCTGATGCAGTTGAACTAAGTTAGTGGCCTAGAAAACCCTTTGCCCGTTAGCCTAGAAATAATTACGGCGCCCTAAACACATTTTTGGAGGCCTAGAAACACTAACTTTTGGTAGCCTAAAAATTTTCTGTGACCCACATGGAAACATTGTTGGCGGCCTGAAAACATTTTTGGAGGCTTAGAAATATTCTTGGCAGAAAACATTTTTGGTGGCCGAGAAATTTCTGGCCTAGAATGTTTTTGTGGTCTATATTTTGGCCGGCATAAAAAAATTTGGAATGGCTTAGAAAAATTTTTTTGGTGGTTTACAGCCACTTTTCAACGACCCGTAAAGAAACATTTTTGGTGGCCTGAAAAGATTTTTGGTGGCCTAGAAACATTCTTGGTGGCCTGAAATTCACATTTTCGGTGGCCTAGAACCATTTTTGGAGACCTGGAAATGTTTTGGTGGCCTAGAATATTTGTCGTGGCCAAATAGAATATTTGTTTGTTTGTCTAGAAATATTTCTGCGTAGAATGTTTTTTGGTCTATAAATAATTTTGGTGGCCTAGAAATATGTCTTGGAGACCTGATATCATTTTTGGTGACCTCGCATAAATATTTTTGACAGCCTAAAAATTTTCGGTGGTCCAAGAAATATTTCTGATGGCCTATAATGGTGTCGTGGTCTATAAATATTTTTAATAACCTAGAAACATTTTGACTGGGGGCCTTGAAACATTCTTGGTGGCGCCCTAGAAATGTTTGTTTCCTAGAAACATTCTTCGAGAAACCTGAAACATTTTTGAATCTGTGGCCTAGAGACATTTTTTATGGCCTAGACACATTTGGATTTGGTGGCCTAGAAATGTTGCTGATGGCCTATAATGTTTCTGTGGTGTATAAGTATTTTCGGCGGCCTACAATATTTTTGATCGGTGACCTAAAACATTTTTGGAGAGCTGGAAATGTTATTTTGATTGCCTCGAAACGGCTTATTTGTACTGTGCTGAAACATTATCGGTGGCCCAGAATGAGACCTGAAAACATTTTTGGTGGCCGAAAAAATTTTAGTGACCTAAAAACTTTGGGAATTACCTGGAACCAATTTTGGCGACCTAGAAAAATTTTCCGGGGCCTACTAAAAATTCCCAATAATTAACAAATTTAGCTAAACTACTTCTGGAAAACGGGGACAAGCACGGGTCTTGGCATGTGATGGGGATATGAAGAATTCGAAATATTTTTTGGACTTTCTACAAGTAAGATATTTCTTACATAAAGACGAATCGTGGAGGGGTGAGCTTTTTCTGAAATTTTGAAAATTACATGATGATTGGAATATCTATTGATAAACGGTTAGGATCGCAATTTAACGATGATCGACAAGAATCTCCGTAAATACACAACGGCACCACATCTCAAAAATTCGTAGGCCACACGTGTGACGCCATTTTTCTTCCAGAATAACAAAGCCCGTGAGAACAACAAGACCCTCTCGAACATGTGTGGTCCCCCGTCTGTGGGATGACTCCTCGTCTGTCATCTCATTATGACTTCCACACCTATGGATCCTATCAGCGAATTACTGATTGGAATCAGCTGGTGGTGAAGTACAAAGATGGTTCAGTATATATCGATTGGAAAAATACGGAGGGCAGGAATATCGGTGGAGTTGAGGTAGGTCTAGCAGGCTTCGGTCTAGGTCGAAGTCTAGGTTTAGGTCTAGGTCTCAGTCTAGGTCACTTAGGTCGAGGAATCTAGGTCTAGGTCTAGGTACTAGGTACACTAGGTCGAGGTCTAGGTCTAGGTCTAGGTCTACGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTTTAGCTCTAGGTCTAGGTCTAGGTCTAGGTCTATCTAGGTCTAGGTCTAGGTCATGTCTAGGTCTAGGTCTAGGTCTACTAGGCCTTCTAGGTCTAGATCTTTATAGGTCTCGGTCTAGGTAGGTCCTAGGTCTAGGTTGTCTAGGTCTAGGTCTAGGAGGTGTACGCAGGTGTAGGCCGATCGATTTCTATGTGTATTAGGCCTCATAGTGATTTTCTGAGATCGGCGGAGACTCCCGCACCAAAAAGATTTTCTGGATCGATTGAAGTATTCATGCTCGAGAAGGGGCGGCCCCGAACACGCCGGTCCCTTTGTTATTCATCCATCAGGTATGTGATCCGGCCCCGTCAGAAAAAGTGTGTTCCGTTTAGCTCCGCTTGACACAAATGTTGGCAGAGACAGAAAAAGGGACACCTTGATAACAAATGGGTTGGAAAACAAGGTAATCGGATGATGCAATCGCGCCCTATTGCACTACCTCAACAAAACACTTTTCCCAGTTGCAGCTTACCTCCAGGGAAAACGCGCCCGGAATCAAGAAATTGCTGAACGACGTAAGATCACATTTGTAGTGGTTCCCTGATTGAATCCAGTATGAGTTCACGAGGTGCTCCACCCACATGTAGGTTGGGGTAAGGTTACTGTACCCCCCCCCCCCCCCCTCCGCAACTCAGGCGCAAGCACTCCCAGCGATTGCAGGTACCGTTCGTCTGTGGTTCCGTAAGCTCGAAAAAGCAATGCCGTAAGGACATTTGGGAACGCAATCACTGCTGTCGCGGTGACGATTTGAATCGTAATTTCGATTTACACTTTAGAGATGAGAGAGAGGGTGAAGTGGTTTTTCTGAAAGTGGACTTGAAAATTAAGAGTCAAAGTTTTGAAAGAAAACTTTGACTAAAAAAAAACACCCTTGAGAATTTGTTCGAATATACGTAGTTGCTGAAAATTAACGTTGTGGAACATTCTAAAACCATTTGAATTTAAATAATTTTTTAAACATACCAAAAAATCATGGGTTCCAAAATTCACGAAAGTTTCGAAAGGTGATTCCCTACTCCTGAACAAACCTCCCCTACAGTATCCTTAAAGTACCCTACTCCAGTACCTATACAGAACTCCTGTAGTACCCTTACAGTCCTAAAGTATCCCTACAGTACCCCTACAGTTGCCCTATAGTACCCCTACAGTAATCTCGCAGTATCCTTACAGTAGCCCTACAGTATCACAGTACCCCTACAGTATTCCTACAGTACCCCTATGAACAGTAGCCCTACAGTAGCCCAATCGCACTGAGCCTTACAGCATCCCTAAATTATCCCTAGATAATCCCTACAGGTGTACCCCAACAGTACCCCTACAGTACCCCTACACCATCTCCATAGTACCCCTATAGTAGCCCCAGTAGCCCTACAGTTCCCAAACAGCCCTTATAGTGCCTATACAGAACCCTATAACATACAATACACCTACAGTACCAGTACGTAAATTACCCCTATAGTACCCCTACAGTACCCTGGCGGTACGTACTCCAACAGCAATACCCTACAGGACCCCCATCCCTACAGTACCCCTGAAGTACCCATACGGTTTCCTTACTGTATCCCGTGAGTATCCCATTACAATACTCTCACAGTACTCAGTACCCCAAAAGTTCCCATACAAAACCCCTACAGTACCCCGACAGAACACTCACGCTACACTCCCGTATCCCTACAGTCCCTGAAGCTACAAAAATTTCCCCCCAACAATTCAAAAAAGCGGTACAAGACGAGCCCGTGCTCAGAGATCTACCAGGGATCCTCTCGATTCAGTGAGCCCGAGGCAAAAGCCGTACGGGACGCGTTGTTGTCGCAGAGATATTAGGGAAGAACCGACGCGCGCCTATATCACACTACACACTTATTCACAGGGAAATGCAGTTAAGCAGTCGTCTTTTTCTCGGCCACCGATCACATTTTCTCGGCCATCGATATTTTCGCCATCGAATTATTTTCTCGGCCACCGAAATTTTTCGCGGTCATCGATATACTCTCGTTCACGCGATATTTTTCCCAGCAACAGATTTTTTTCTCGGTCACCGATATTCTGCCACCAAAATATTGTTTTTCGTGGCCATCTATCCCATTTTCATCGGCCATCTATATTTTCTAGGACACCAATTGTTTTTCTCGGCCTCCCCGATACTCGGCTACCAACATCGTTTTTCTCGGCCACCAATTTTTTTCGGCCTACATTTTATGTCTCGGCCATTAATTTTTGACGGCAATCCGAAATTATTTCGGTCACCGATATTTTTCACGGCCATCCGCCAGAATTTTTTGAAAATTTGATTTGAGCAAAAATCTTCAGATTTGGATCACACGTCCATATGGTCACAAGAAGGATGCATATCCAGGAGATATTAAGGATTTGGTGAGTTGGATGACGCGTCATTCTTCTTGAAACGTTGAAAGTCAGATTTCCAGTACGAAGTTGGCATAAAAGCTGCTCAGGCTCTGAAACGGGTTTACGGCACAAAATACGTAGTCGGAAGCGGTGACACGCACAACCCGGCGTCTGGAGATCTGAAGCTTGGGCAAATATAGGCGCGAGGCGAAGGTCAAAGTTGTGTACCTTCTAGAATTGAGGCCCGACGAGAATATAAAAAAAACGTTCAAAGTTCCTGAAAAGTTGGGCGATAATTTCAGCCTGGGATGGGGTCATAACGAGAAGGAGCTGATCCCGACACTCGGGTCTGGTTGAAGGTGTCCGAGTTGTGGCGGAAGCTGTGCTCGATCGGATAGTAGCCGGCAAGTCGACGGATGCTCCAAGAGGTAGGCAAACTTTGATGTGCCTGCGTTCCTGCCTTGTGCCTATAGTTTACGAATAGGCACGGAGCAAGTAGGCAGCAAGCGAAATGTGGACCGATAGGCGTAAGGTTAAGGGCTTGCGATGCTTTTGCGTAGCGAAAAAAAGAAAAATTTTTAAATTACAGTGCTCACGGCCTAAAGGAGATGGCTTCTTAGGTAGTCACTACGATGCTCCTTGACTCTCTGACCACAGCCCCTTGGTTTCTCGATTTTTCGTTTTAGAAATTACACTTGTTTATTTTATGATTGTTGACACGCTAAATGTTTATTTAAACATAATTTTTCTTGAAAAAACAATTTACATTTAGAGAAAATAGCAGCGAGTCGTGGCCGCGGAATGAAAAACTCGACCACCAGCTATAAAATTAAAACGTATAATAATTTGGTGGTTACTCAGTTTTGCAGAAAAGAATGGCTGGCCGAGTTTTCACGTTTCTAGGCCATCGGTTAGCAAAGTTGCTCTGAAGCGCTTTCGCGAATTCGTTTCCAAATAAAAACTGTAGGTGAAAACTCGACCGCCCACGCATTCTTAAAGCCACGAAATCGATTGGAAGTTCATAATTTCTCGGTCACCAATTTTTTCACGGCCACCGATATTTTCTCGGCCACCGAAGTATTTTCTCGGCCAATCAAAAGTTTTCTAGGCCACCAACTTTTTCTCGGCCATCTATATTTTCCCGGCCTCCGACATTTTTTCTCGGCCACCGATATTTTTCGCACCCGTCTATATTTTCTTGGCTACCAATTTTTTCTAGGTCTCCGATACTTACTCGGCTACCAACTTTTTGTCATAGATATTTTTCGCAGTCATCTACCTATTTTCTCGGTCAGCGATTCTTGATAACCCGTGTTTTTCTCGGCCAACGATATTTTTCTCGTGACCATCGATATTTTCTACCGGCCATGCCAAAATTCATTCTCGGAGCCACTTATATTTTTCTCGGACACTAAATTGATAATTTTCTCGGCCACCTATATGTTCTCGACGACAGATTTATTTCTCGGCCATTACTCTACGGCCTCCACCGACCTTTTTTTCGGTCACCGATTTTTTCTCCGCCATCTAGATAATCTCAGTCACCAACTTTTTTCGGTCATTGATATTTTCTCGGTCACCAATATTCGTTTCTCAGGCATCAATATTTTTATCGTCCACCGGTATTTTATCGGCCACCGAAATTTTTCGCGGTCATCGATACGTCACGGATATTTTTCCCAGCAAAGTTTTCTTCTTCACCGATATTCTCTCGGCCACCAAAATTTTTCTCGGCCCCGATTTTTTTTCCACAGATATTTTTCTCGGTCATATTTTTCTGCCATATTTTTTCTCGGCCCTCACCAATTTTTTTCTCGGCCTCGGAGTTTTTCGTGGCCATCTATATTTTCATCTGCCGTCTATATTTTCTAGGCCACCAATTTTTTTCTCGGTCTCCGATACTTTCTCGGCTACCAACTTTTTCTCGGCCACCAACTTTTTCTTGGCCACAGATATTTTTCTCGATTAATTTTTGACGGCCACCGAAATTTTATGGTCACGATATTTCACGGCCATTGATATTCTTTTTGCACGGTGATACTTTCTCGGCCACAAATATTTTCTCGGCCACCGAATTTTTTCGCGGTCCTATAAATTTTCTCGGCCTCAGCAATCGATATTTTTCTGTCTAGTTTTTTTTTGGCGGCCGTGACCTCCAAAGAATTACAAAAATAAACGATACATCTCATATTTTGTGCAACCTCAAGTACCCCCCCCCCCCCCCCTATATATATTGTTACAGAAGCCCCAAAAGCTCGCGCATTCCGATTCGGTGCGGCACCGAAGGAGTCTATGATGTTTCGATGTCCGAAACGCGTGCAAACGAAGGGTTCAGGAACGGCATGAGGCAGGACGGTGCCAATTTTCATGCGAGAACTGTGCCTACTCTTGCAATTTCTGTTGATTTTTTTGGTAGCACGTGGCACTTCTTATTTTCTGTATATCCATTTTGTCTTCTACATACAGGAATATATATATATATAGGATATGTTTAAAAACCTAAAACCTAAAAAAAAACCAACCTAATACAGTGTTCGACGAGCGTCCCCCGCCGCCGGCGGACACTCATTATTTGCATTGTGCTCACCGTGAGGTCGCGCGGGAGCCCCGGTGATGAGCATCTCTTTACGATGTCCACACGAATAATACAATAACACGGGCTCCTCTTCAAATATGACAAAATGTCTTTGGCGTTCTCTCCTGACTTGGAGCTTCTGGGTCTTCGACCCGTTCTTGTCTGTGAGGCGAGATGCGATTACCCTCTATATTATTTTTGGAGATTTTTTGGTTTTCTAGGGGCTGCGCCATTCATAATACAGATGATAATGCCGGCTATCATAATAAGTCCACAAAAGTACCCATATGGCCTTGAAGGAAAACTCTTCTTCACTCTTGGCGTGGGGACATTTGGTTGTCTGTGCTAGGTTTGATGCTGAACATGGTAATTTAAATTTCCGAGGCCATTGTATATGTTTTCTTCTAGGCTACGACATACAATTTTTTAGGCCACAAAATATTTTTTTTTAATTGTATAAAAACGGAATGTTCCATAAATTATCTATTTTTGAATTACAGTTAGTCTGAAAATTTTTTTCAAGGGCACCTGTCTAGGTCAAGAACGGATTTTTTACTGCCGGAGAACATAGGCATCAACTTTTTCTGCCACGATTAGACAGATGGAAGAGCTTTTCGTAAAAAAAGCTCGGCCTCCACCCCACCTAACCCGGCAAAAAACTTGCAGCTACAAACTAACGAATCAATCCGGAAACTGACGGAAGTAGGCGTGAGATATCTTCGAAGTCTGTAATCCCTCTCGATCTGGATTTCTGGCAGCCTCCTACGAATATCGGTTAGTGTGACTTAACCTCGTGATGCTAGCGTGCTCCATTTATAGTTTGGTCTACGTAGATCTACCAAAAATGCAGGTGAAGAGACGCTCTCAACTGATTCTGTATGGTTAAGAACGCTGACGTCACATTGTTTTTGGGAAAAAAATTTCCGCATTTGTAGATCAAATCGCGATGGGACAGTTTGCCACCACGTGCTTACCCAGGAAAATCTGAAATCGGTGTTCGAATTTTCAGGAGCTATCGTAGACTTGACAGTTGCTCCGCCGGATGCTCCAAGATGAAGGATTTAGAAGAAGGTCAGCTACATCGTGGCGGTTAATCATTTGTCGTTCGTTTGGTTTTTTCTAGGCCACGGCTATCTGTGACGTCACTAAACTAGTTTCCAGAGCAATCGAAAACGAGGGAGAAATTCTACAGTGTCACCCGAGAGTGTCGCTGGTTTTTCTGCATATTGCCGACAAGTCGGACAATGGAGGAGATACAAGCAGAAATGAAGCGGCTTAAGAAGGAATACCCGACCCCTTATCGATATCGGACAAAGTAACGTCCGTATAATCGTACGCTTTTGGTGATGGAAGGTAAGACATGCGAACGCGATCTATTGGGTGGGCGTGGTCACGTCCATTTGCAAAGTGGGCGCACGGTTCCTTTACAGTGGACGCCAGCTTTTGAAGTTTTGAGTAATTTTTATGGGAATTGCTACGATAAATTCATTTAAAAAAAACCCAAGAATACTTTTAAAGTCGTAACGAAAAAAAACAACCGTGCGCACGTCTTGCAATAAGTTAGGGCGCCCTAAATTTTAAAAACGAAGGAATTTCATTATTTCTAACGCTCCAAACTCATTTTCACTACAAAGAACACGCCTCCTGGGAAAGCCCTTACTCATTTGCTGGATATATGACGTCACTAAATTAGTAGAGTGAAACCAGGTGCGCTCCATTGTACTACGCACACCGACGTGGTGTCAAACAGTGTCCCATTTCTGTGTGATCTTCCATAAATGCGATCGGATTTCTAAACAGATGGCGTTCGCATGGTTAAGAGCGTGCTGACGTCACAAACTTTTCTCTGCAAGAAATCATTTTTTGTAGATAACACTAAAATGGCACTTTGACGCCACGAACCTGCGCTCTCACTTTCAACACTCCCATTAAGCATTTCATGTACGCGCCAAAACGCACGGATTTCTGGCTCCCATTTACATAAATTGAAATTTTGAAAAAGAGTGTGCCGAACTAGGTCATTTTGGCTCGGCCATATGTGGTGAGATTTTCACCGCGTTGCGTGTCGCGTCGCGGCTCAATTTAAGTTGTAAATCTGAATGTGTTTGTCCGTGTGGAGTACCCGACTATTCCACGCGTTGCCCGGAATGCTATTGTGGATGGAGCACGAACATGAAAATTCAATAGAAGGCCAGAACCCCCTGAAAACGCCTGCCGCGCCCCCGCCTGCCTTGCAGCGCGGAACCCAAAAAGTGTTCACGGCCGCGGCGAAAGGCCCTCGACACTATGTGGTGTTAATACCTAGCTATTGACGCCTTAGTGTAAAACAAACATGAGATAACCGGAGAACGAAACCCCCTCGGGTCGACAATCTCCATGTGGATTGACGCTGGAATTCATGCTCGAGAATGGATTGCTACCCGGCGCCCGCAATGTACATTGGAGCTTCTCCTCGGGTATGAAAACGACGCGACGGTGGCTAAGCTGATGGACCATATCGATATTTGTGTTATATTCTACCTGTGATGAACCCAAATGGGGCCATATGAGTATTCCAGACCTGCGAAAAGGTTGGTTTTTGAACCTTACAAAAGCCTTAAAACTAGTGTTACTATTTCAGAACCGCATGGGAGGAAAAACCGGAGCCCCGCGATGCGCCTGGCAAACGTATGCTGCTGTGGAATCGACCTCATCAGGAACTTCGATTGGTTCTCCTGATAAGTCACGTGGTCTGAGAAAGTCTCATTGAATTGATCTACAAAAAATGCGGGAATTTTTTGTTGATCGAAGCGAACTGGGACTTCCTGCTCTAGTCGTAGTTAGCTCAATTACACCTTAAAAAGTAACTTAATCTTAAAAATTTCCAGCCACCGCTTGTTCGGGATCCGTCACGACACCTAGTTTTTCACGGCCCGGCGGCCTTCCCGGAGCCTGAATCACAAGCTGTCAGGGATTTCCAGACCTGGAGCAAAACACACCCGTTCATCTCGCTGCATTCCTACTCCCAAATGTGGTTGATACGCCATATGGACATCAGAAAACAGAGTTATCCACAAGACTACCATACTGGACGGCGGCCATAGGCTCTGCGAGTAACTAAGGCGTTGTATTGTATGGGACGAAATATCAAGTCGGGACCGGCGCTGATTTGATGTGTAAGTAATATCCTTTTTTTCCAATTTTTAAATTTCTAAGGATTTCAAGCAATTTTCAAATTTTGAAAATTAAAAAAACAATTTTTTTCGGAATGTTTTAAAATTAAAAAAGAAATTTTTTTAATAGATATTTTAAAGTTTTTTTTTGGAAAATTTTGGATTTCTGAATGGCGTAATTTTCTTTTCAGCTAACTGGATGAGATTAGTAAAGATTTTTTTAGGACTTTTTAATTTAGACATTTCCGGAAAAATTTTTAAATTATTAAAATTTCGAACTTTTTCGATATTTTCGGATTTTTTTGCAACCATGGTGAATTTTATTTTTTTGGATTTATTGGAATCACTAGGAGGTGGGCAGCAAGATTTTTTCCGGCAAATCGGCAAATCGCGCAATTTGCCGGAATTTAAAATTCCCGCCAAATCGACAAGTGCCGATTGAAAATTTCTGGCAAAACGGCAAATCGGCAAATTGCCGGAATTGAAAATTTCTGGCAGACCGGCAAACATGCTAATTGCCGATTTGCCGAATTTATCGATAAATCAGTTGCCAAACGGCAATTTCCCCCACCCATTAATGGGATCTTTGAAATAAAACATGAAGAAATTTTAAATTGTTGGAGTTGAATTTTGTATTTTTCGGGAATTTTAATAAAAAAACGCTGAAAATTCTAAATTTTGTAACAAAGTTATTTGTGATTTAAAAAAACATTTTTTGGACTTTTCTGAAATTTCACGGATTTCTGGCATCTCTCATAAATTGAAATGTGACGAAGAGTTTTTGCCGAACTTGGCTATTTTGGCTCTGCCATATCTGGGATGGACGGCGCGCTTCATGTCGCGTCGCGGCTCGTAAAACTAAATGCACTTGTCCGTGTGGAGAGAAAATTCAATGAGGAAGGCCAGAACCCCGGATTTTTGAAATTTTGAAGTTCTGAGAAACCTGTGAAAGACTCCTACCTAAACCTGAAGAATTTGAGACGAAGCTTCTGGAGATCACATGATTTGGCTAAGGGGAGCAGCTTAAGGTCCCCTATGCCTACCTGATTGAGCTCCGACCAAAGAACACCATGATTGGGTAAGCGATGGATCCTATCAAAAATATTTCATTCTAGCCACGGCTTCCTTCTCCCCGAACGAGAAATTGTGCCCACTGGACTAAACCTTCTAATCCATCAAAGTGGTTTATGTGCCGACGAGCTTGTGGCGCATAATTTGTGGATCCTGTGATTCGTATTGAACCAAGCTGACCACAACTACCACAAAGCCCGCAATTCCCACCGTATCGGTGTGTGGATGGTCACTCTATAATCGACACCAACTATGGCGGTCGGAGCTTACACAGAAGCCTACGGAAGCTCCAACCAGGCACCACCACTACTACGAAAACCTACTACTACCACAACGACCGAGGAGCCTACCGAAGCCCCAACAGAACCCAGTCCGACTACTGTCGAGGCCACCGAGGCTTCTACAACTACAACGAGAACCTTCCACATGCTCTGATACAAGTACCACAGAGAATTCTGAGGAGTACCAACCAGAAGACATCCACACCAGGGGCACCTGAAGCAAGCACCAAAGTGAAGAGGATGGTTTTTGAGTCTCAGGCTTAGGCCTATGGCTTAAACTTAGCCTTTCTTAGACTGAGGTTTAGGAGCTTAGGCTTCAGCTTAGGCTTAAACTTAGTTTTAACTTAGGCTGTGGCGTAGTCTTAGACTTAGTTTTGAAGGCTTAGAGCTTAGGCTCAGACCTCGGCTTAGGCGTAGGCTTAGAATAAGGCTTAGCTGTTTTAGGCTTAGACTTAGTCTTGGGCTTAAGCTTCGGCTTAGGCTGTCTTAAGCTTAGGCTTAGGGATGCTTGCACTTGGGCTTGGCTTCATTGGCGAGCGTGAGCTATTTAGGGTTTTATGGGAACTTCCGCACCTTTAGACTTAGGCTGAGGTTTAGGCTTAGGCTTCGGCTTAAGCGTTCTTAGGCTTATGCTTAAGCTTAGGCTTGGACTTAGGCTCATACTTGGGCTTAGGCTTAGGCTTGCACTTGGGCTTAGGCTTACTTATGCTTAGTTTTAGGCTTAGATTTAGGTTCAGGCTTAGGCTTATCCGTACCTATGCAAATACATTTTCTGGCACAACTGATAGTTGCCAGCGACCTATTTTAACTTCGAAATTCCCACGAACCATTCCAGGAAACAATCACACCGATCAAACTGCGTCGACTACGGTGACTGCCACTGTCGTCTTTGGCACTGGGGGTCTTTCAGCTCTGCTATCGGATCAGGTCCAAGTTGTGCCCCAAAGACTTGCGACTCGCGGTGCTCTTTTTCGGTGTGAGGCGCACGCTGGAAACTATCGTATGACAAATTGTCAATGTATTGTATAAATGATTTCCAACTTTCGTAATTGTGGACTAAAAACTACGTTATATTTTTCATGCCTGACTGCGTGGCAGCGTGTCAGCGCCCGACATTTTCTGAGTTCCACGACGGGATCCTGGCAGGCGTAGGCGTTGCAATTTTGACTCATCAAATTGCTTGGAATAATTAAGTACTGCTACAAATGATGTCACTAGCTACAAACTACAACTAGGAATTTCACACTACAAACTACAAACTACAATCTTAGCTCTTCAAGCTATGAAATACAAACTAAGAAATTTTTATTTTGCAATATTTTTTAAACGAGGTGTAATTTGGGTATAGTAAAAACTGGAATGACAAAAGCAAATCACAAACGACAAACTAGAAACTAAAAGCGGAAACTGCAAACCAACTACAAACCACATACTACAAACACAAACTACAAAAATTACGAAGTACACTACAAGCTACAAACTACTGAACTCTGAATAAAGTTGAACGTTTTTTTTGGTGCAATGATTGGCGTATGAATTGCGAAATAAGTGGTTAAACACATACTACAAACTACTACAAACTACAAACTAGAACGATCCTAGAAACTACAAACTACAAACTACAAAATATATTACAACCTTAGAAATTTTGAATTTTTAAATATTTGTGGAACAATCAGTTTTAATTATTCGACGACTAAAGTCAAAGCTGAAATCATAAAATGCTAACCACAAACTACCAACTAAACTACAAACGGCAAACTACAAGCTACAAATCACTGAACTCTAATAGAATTTGAAAGTGTACTCATGGTTTGTGCCATTACTGGACGTATGAATTACGAAACCATAAGTTTTTAGTGACCCACTACGAACTATAAATTTCAGAAAACTACAAACTACTAATGAATGTAACTACAAACTACAAACTGGAACAACAGCAAACTACAACCTACAAACTACAAGCTACAAACGCTTATATATGATTATTCGATTTTAGTTATTTCCTGTTTTTTATTCTTTTCCAAATTCTCAAACTCTACTGAAATAAAAATACCTCACACAAATGTTTCTCATCATGCATCACTGACTAATTATTTTCCAATAAACATAGCGTTTTGAAAAAGTATGGAAACAAAAAATGGAAATCAAAGGCGGAAATATGCATTTTTCTTACTCATTTTCTTGAAATTGGCTTCATGTGATTGGACTTTTTGATTTTTTGTTGGCCTTGTTAAAAACGTGGTAGGCAGGCATTCATGCCTACGTCGAGTGCCTGCCTACCAGTCGAATTCGAACCCGCAAGATGTCGGCCGCTCCCTTCGATTTTGGAAGATTTTACTTATTCCTCTTCTGCTAACATATTAGACAATTATTTTTCAACCCGTGTACACAATAGGGCGGCTAAAAATTAGGTTGGAAGATAGAGGTGTACAGGAAACGTTTATAAGCTCTTTATGCGCTTACTACTGAGTACCACTTATTTGCCAATGCATTTTGTTTCTCAACAAGTTGGAGATTCCAGAACAACCAAGGTTTGGCGGGGCTTACTTTGAGGCAATTTTGCGACTGTACAGTAGATTCATATGTGCGAATTTAAGTAGACTTTGAAAACATTTAGGCGGGAATTCAAACATTTATTTTTAAAACCATCTTGGCGGCGTGATCAAAGTTTTCTAGTTTTTCGAAAACACTTTGGCGGGAATTCAAAATGTTAATTAGTCTTAACTTCCTGAATGCTCTAGATCAACCTTCTGGAATATTTTAGAAAACTCTAGAATGAGAACCTTCTGAAAAATTCGAAACAAGTCTAGAATGTTCTGCAGAGCCTTTTGGACAAGGCTTTTCGAAAAAAATCTGGAATAGACTTTTGGAAATTTTGAGAAAGTTCTGGAATGTTTTGGAACCTTCTGGAAAATTCGAGAAAATTCTGGAATGTTCTAGAACCTTGGAAAATTTGAGAAAATTCTGGAATGTTGTCGACCCTTTGGAAATCCGCGACTGGAATGTTGTGGAACCTTCTGGGAAATTTTTAGGGGAACAATCCTGGAATTCTCGATAGCTTCTGGAATTGAGAAAATTCTTGTCACCAACGTTTTGTGAAAAAATTTAGCTGGAAACTAAATAATTTGAGAATTCAAACTTTAATTTTTCCAATTTTTTCGGATTTTTTTTTTAGCTTTTAAGCTTTTTACATTTTCCATAAATTTTAGATTTCAAAAACAAAGCTTAAATTGGCAAAGTTTTGACCAAATTTTTTGGCTTTATAGCATACAAAAGGTTGAAAAAGTCCACAAGGTTCTTGCTCCACACAGTCCCCAAAAACACATCAATTTGGTGGAAATTCAAATCATGTTTTTTTTTCAAAAAATGTAATGGCCTAGAAAATATTTCAGATTCAAAGCAGTAAGGCCGTCAATCCTACCTCCGTTCAATCCGTAAAATACCTAAAAATCAATCCCCAGGAATTAGTCTCATCAAGAAAGAAAAGAGCTCTGCTTGTGCCCACTCCTCATCTCTTCTCATTTATTTGTTTGCAATTAAACACATCCTACTCAGACTGCATAACGAAGGAAACAAAAAACGAAAGAATAACGAAATCCCAGAGCATATTTCCTTTATTAACCCTATTCATTATTTTTGTATTCAGGTGGAACAAAAAACCGGCTCGGCGGGTTTATCTGTCTGTAAATCTTCTACACGCCTACCTACAGCGGCCTGCCTGACTGACTATGTGCCTAGTGTTTTTTGTCCTTTTCGGTTGGTTTTTTTGAAAAATTTTTTTTCCTGATTTTTTTTGTCGTTTTTCCATTTTTCTGAATTTTTAGGAATTTATGTAAGTTTCTCTTTTTTCTCCCCCCCGCCGGAGCCTAAGCATAAGCCTAAGTACGCCTAATGGTGCCTAAGCCTAAGCCTAAGCCTAGGCCTCAGCTTAAGCCTAAGCCTAAGCCTAAGCCTAAGAGGCCTAAGCCTAAGTCTAAGCCTAAGACTGAGCTTAGGCTTAAGCCAAAGCCTTAAGCCTACTCCTATGCCTGCGCCAAAGCCTAAGTAAGCCTAGGCCTAGTCTAAAATAAGCTCGGCCCCTTTCTGGGCCAAAATTTGTACATGTACCTCCTAAAATTGTTTCATCGTTAATAGCCATAAAAACTAGGAAAAATCTATTTCAAATTCTGAATGTCAAAGATAAAAATTCACAGAAGTGCGGGAAATTTGACCTCACCAGAAATGGGGCGGAGCCCATTTTTGGATAGGCTCCACCTCTTTCTAGGTTCTCTAAAATCAAATTTAGCTGTCAACTTTCCTGGTAAGCTTTAGTGGTTTCATTTTTTGTATTCATCACATTTCTTTTTCATTTTTTACATTTTTTCATAATTAATTTTGATCTACTTGTTTAACTTGACCCTGCCCCCCAATCTCCTCAAAGTAATGGGAGGAGTCTAAACAAGGTAGATCAAAAATAAATAGAAAATGAGAAAAATTTGCCATCGTGTTTTTCGATAACACTACAGTTTAATCATACAATAATCCCACAACTTAAAATTCAGCAAATAACCAGGAAATGGGCGTGGCTTAGATTTTCAAGGTTTCGCTGTTTTTTCCAAGTTGTTTCTGATATGAACCGGCCCCGACAAAAAATGCCACAAAAGTCGTAGTAGTGATGTGTGACGTCTGTTCTGATGACTAGAATTCATATTATAAAGGTCGAAAAATCCCTTCCGAACGAACCCCCCAAGATCATCCTAACATCCCAGATTTCTTCACCCGCCCGCTCATATAGCTTTACCCACCTAATCTTTTTGCTTATTTCTCAATCTCCGTCTTTCTTGCGTTTTTAATTAATTCAAGGAATCAAGCAGTTGTGGTTAATGGCTATGAATTGCTTTTTTATTGATATCTTTAATTATTATTTATTTAGTATCTAGCCATGTACATGTGTTGAGTCGAATAACCTGAAAATTTTGTGCCAAGTTATGAAGGCGGGGTCTTTCATACATTTTTTAAATTGTTTTTTGGCTAAAATTGTATGTATTTTGAAAGTTGTGTGTGTTTTCCATTTTCTTTAAAAAAACATCAAAAAAAAAAATTGGTATGTAGTAACGTAGGTAGGCAAGAAGTAGTTGTGTAGGTAGAGACTTGAAAATAGCAGCTATGAATAGGTGCGGTACTTTTGTAGTTTAGGCAGGTTCGTAGGCAGATAGGTGAGTAGAAAAATCATTCAGAAGACATTCGGCCAGGTAGGATCACTGGTAAACAGGCATAATGTAGACGTACGTAGGTTAACACTTACGTACGAGGCAGTAGGCATCAGGGCTTTGTGGCAACCGGCAACCGGCAACCAAAAACCAGGTTGCCGGTTACGGAAAAATTGCCGAAATTTCAGCAACCAAAAGGTGCTCGCCCGAATTTTCTCGAATTTTCCAAAAGGTTCTAGAACATTCCAGTTCTCGAATTTTCCAAGAAGTTCTAGAACATACCTAACTTTTCTTGTCGAAGTTTCCAAAAGACCCATTCTAGACGCAACATTCCAGAAAATGATATTCTCCGAATCTTTGCCTCAGACTAGAACATTCCTGAATTTCGTCTCGAATTTTCCAAAAGGTTCTAGAACATTTCAGCATTTTCTCAAATTTTCCAAAAGGTTCTAGAACATTCCAGAATTTTCTCCAAGTTCCCAAAAGATGCTAGAACATTCCAGAATATTCTCGAATTTTTCAGAAGGCTCTACGATGAATATTCCAGAATTTGCTCGAATTTTCCAAAAAGTTCTAGAACAAGTTGCATTTTCAGCGTACGGCAACTTTACTCAGCAATTGCGGGTTGGCATGTAGTCGCAGGCAGGCATGTTAGTAGCGCAGTTTTGACAGTTTTGAAGTTAACAATCCTACCTGCGATGCACAAGAAAATGCGCGGCAGTTGCGGACCGGCAATTCTACCAAATGAGCTAGACGGTAGGGCATGTTCTTCCGAGTATTTTTTAAAAAAATTTGGCAAAAGTATAGCATGCATAAATCTTTGTTTTATTTGAAAGTTTTATTGGCTAGGAACAACCGAAAAAGTACTCAAAAATTGTCGGAATCTTGAAAATGTGAAAATTTCCAACATTTCGACTATTACTGGAGATTTTTACAATTTAGTCTATTAAAAAAAAACAGTTTACTTTCAAATAAAGCAAATTTTTCTATATTGTGTGATAAAATTTTAATGAAAAATAGGGGAACATGCCCAACCGTCTCATTTTGCCTAGAATTGCCGCGCACCGTGTTAGTTTATCCCCGTAAACCTCCAAGCAATATGGCAGGAGTCCTTCCGTCCGTCCAAAACGTCATAAAAACTCGTTGGAGATGGCAAAATTGGAGATGTGCCAAGTTTGCTGGAGAGGTGGGGGGAAGGAGACAATCATGTTGTCTGCGTACCTGAGGCCAGACTCGTCTTGTTATCTCTCTGTACCTACCTGGCAAATGGGACCTCCCCAGACCGGTGAGTTTGTCCTTTCAACACCTATTGTTTCTGTTGGTTTGATACCTTTTTTTCAACGCTACTTTGCGGGAATTTAGACTGATTTCTCATGGTTAGAAACGTGCTGACGTCACATTTTTCGCGGGAAAAAAAACCCACATTTTTTGTAGATCAAACCGTAATTGGCTAGCCATTCCAACAATTCACTGTTTTTTTTCTGAACAAGTCGAAGTTTTGAGTTCCGCACACGCAATTCTGTCTCTGATAAGTTTGGAAGTTTCAAATAGAAACCTCTCAATTGTCGGACCAGCGCGCTACTTCATCATACCCCGCAAATTGAACTGCTCGCGGCAAAATTTAAAAATTGATGCTTCTCCATAAACATACCAAAACTACCTAAGACTGAACTTCATTATCTTCTTTTAAACTTAAACATTACCTTAAACGAAAAAACGTTTGTACGAGTCAGAGTGTCTCATTTCATTTCGATCTTCATTGATCTACAAAGAATGCGGGAGAAGAGGCGCAGAGTTTTCAACTACTTTCGCATGGTGAACGTGCTGACGTCACATTTTTTAAGAAATTCCCGCATTTTTTGTAGATCAAACCAGCCATGTTGGCAGTCCACGTGGCCGGCGTTTGTAATCGTTCAGTAGGTAGGTAGACACAGGTCAGTAGGCATAGGTAGGCGGTCGGTCTGAGGTAGGATGTTGTTGACCATCATCCAACGTAGCAAAACATGCTTGACGACTAGCCTCAGGATAATCACAAAGTTCTACGTAGTTATGATTTCAAGCAATGAGCACATTATATCACTGACTAAGCCACAGCTATAAGACCCTCCTCCGAGTATATTCTGAGGATCACCAAACATCTAGACGTAGGTTTGCAGTCTTTCTGTTGGAACATTAACGAGAGTAAATCTCATCTGTTAGGCAAACGACCAATTTCAAGTTCAAAACTATAAATATAAATAAAGCTAGTAATTGAGCCAGTCCTACTTCAAATTTCCCACAAGTTCATTACAAACCGTCCAATTCCCAAGCCCATGTACTCCCACTAATCAGTTTCTATCCTTGCCGCCCAACTTTCCAAATTCATTTATCCGCTTTGCATAGTTTTCGGTAATCTTGACGATTTTCAGAGGTTGAATTTTTTATTTTTTCCAAGAGTTACGCAATGCCAAAATAAATTTTTTTTTGTATTCTCAACAGAAAATTGCTAAATTTGTCCAACTTCCCATTTCTCGGAATTTGACGTAATCAGTTTTTTGAATTTTTTTGAAATTACTGATTATCAAATTTTGTTGGAAAGTTTATTCCTTTAACCTACACAGCTACCATATTCTGTCTAGGTGCTTACCTACACGCCTGCTTCGTGCCTACCCGCATACCTGCAGCTGGTTTATCTTCAAAAAGTGCAAAGAGCCAAAAGTTTCGAATTGACAAAATACGTGCTAATTGTTTGGAGCAAATTTTGCAACATGCCAAAGTTATCAAATTTCCGCATAATTCCAAAATGGCAGCCCGACATCATGTGCCTACATTCCTGTGGTCTGTAGGCCTGACAAAATGTCCATCAATGTATGTACCTATTTCATACTTATCTACCCGTATAAACATAGTTCATCTCTACCTCAAACAGCATGTTACAGGCTTTCTTCTCTCCTACCTACCTACCTTCATTAACTGCTCTGTTTATTGACTACGGCTGCCTACCTTTAGCATGCCTGGCATGCCTTCATACCTACCTCATTTATCAGATCCTTATAAAGCGTATGTACAAGTTCGCCTACCTATTGTGTTAATAACGATCACCGTCTCTAGGCTAACCTGCCTAATTGTGTCTACCTACTTAGCTATCTCATGCCTGCCTACTAACCAGCTCAAGTACCTACTTCATGCCTACCGGCCTACGTTCCTAACAACGTGCCTACCTGCCTGCTCACTAGCCTAAGTGTCTGCCTACATGAATTGTTCGTTAGCACACCAGACTTATCATATATACAAAACATAAAAAGAAGATAAACAATAATAACAAGTGGGTAACTCAAAAATGAAATTGGTTTATCTCCCTGCTCCGAGAGCACCAGCACTTTGGTTTAGATTCCGTCACTACAACTTCAAATTTTGCTTTGTTCGAAGGACCTTTTCCTGATACATACTAATTTTTTCGGATCCGGTTGGCTCTGGATTTCAAGTTTTATAATAACTTGGGCTCCCAGTGACGTCATCAGTGGAAGGTGCAATTTTAGTAACTAGACAGCTTGCTCCTAGTTTACTGCTCCTCTTCTCAACGCCATGAAATAAGCCAGAGAGAGAGAGACCCCTCATCGAAAATTAAATTAATCGCTAAAACGTAGGTAGGAAAGAGAGTGGGAGGGAGACTCCAAAAAAAGAGTCAGGGGGGCTCTCTCTCTATCTCTCTCTCTTCGAGCGGCAAATCCGCTTTCAAATTCATTCAAAAATATGTGCGCAACCACCACCACTACCACCGGCTCCAGGTGGTAATTACACTTGAAAACCAAGTACTGGTTTTCGTGGCCGGGCAACTTTTAAGACCCCGGTGGAATTTTGTAGGTCTATTTAAAAAATTGCAATTGCGCTTTTTTGTACTGTTTTTTTTGACACAACAACTTTGAAGCTTCATGTAAAGCTGGAACAGCGCTCTAATGACAATTTTGACTGCATACTCGCACTGTTGATAAATGGTCCGTGTACTCCACGGGGGCAATTAAACTGGATTTTTTTCGATTAAATAATATCTTGATTTTTTGCAGTTTTGGCTTAGGCTTAGCGAGGCGTAGGCTTAGGTTTAGTTTTTTCTCGGGCTTAGGCTTATGGTGAGGGTCAGGCTTAGGCATAGGCTTGGGCTTAGGCTTCGGCTTAGACTTAGGCTTAGGCTTAGCCAGGCTTTTGTCTTAGGGGAGCCTTAGGCTAGTTGTAGGCTTAGGCCTGAGGCTTAGGGGCTTAGGCTTCCCTAAGGCTTAGGTTTAGATTTAGACTTGGGATTTAAAAAAGGGGCTTAGGCTTAGGCTTAGGCTCATACACAGGCTTAGGCTCAGACTTAGGCTTAGACTTAGGAGGCTTTGGCTTAGTCTTAGGGATCTTAGGCTTAGTGGACTTAGGCTTAGGCTCAAGCTTAAGTTCAGGCTTAGGTTTCGGCTTAGTCTGAATATTTGGCTTAGCCTTGGGCTTAGGTTTAGGGAGGGCTTAGGATTAGGCTTTGGCTTGCCGGCCACCTAGAATGTGGTTTGACAGCGGTAGGCTATCCAAATTCTAAAAAAATCGGCTACATAATTAATACTTAGATGGGCCTATAAACCATTTCTCTAGGCCATCCTGCGAAATTACCAAGACAAAAAATTTCAGCCGCTAGGGGAATAGAGTTTCCGTTTTCCAAGGCCACCTCAAATTTACCACAGTCATATGTAAGGTATCGGAGGGCACTGTAGAAAATTCAGTATCAAAAATCAGCGAAGTAAGCATTAAGAAAGTTTTTTGTGTGTGTGTGTTTTTTGTGGGAGAAAACATTTCCCCTCTCTTTCCTGCCTGCTCATTTGGATACCACCGCTAACCCATCTTGACTTTGATTACCCATTTCCGTCCCCCTTCTTCGTCTTCTTCTACCCGGGATAGAGAGAGAGCTCTATATATTTTCGTGTTCTTGATCTGTTACCGCGCATTGAATTTGTTTGAGCTGCCGCCGGCGAATATATACATGCATGTCTAATTTTTTAAGTAACTGGAAAATCTAGGAATTTTAACGTAATTTGGTTATAAGCGTACAGATCGGCCCATGCTGGTGATTGTACGAAATTTTAATTTCATAGTGTCTGCAGAGAAGCTAGGCATATCCACAAGCCCCTACGTGGCCGTCAAAATTGAAAACTAGGCGATTTTTTCTCGGACTTTTTATCTACTTTTATTAGGCCCTGTCTTCTTTTTTGCAACGTTTTTCTACTAGGTCACCAAATTGTTCTACGCCAAGCTGCCTAAAACTCGGCCACCGATTTTTATTTGCGTCGGTCTGTAACATTCAGTCTCCGACCAGCTCGACTTTTGCTACCTGGTCGCCAATGTTTCGTAAGCGACATCGAAAATGGCACTCGCTGTGACATTTGTACTTTTTTTCACCCGGCCTAGAAATTTTGAAAAAAACTCGGGCACTGATTTTATCGGCCTTGGAATCCTAGTGTAACTTTGTGGCATGATTTTTTATTTATTGTCCATCCAGTTTTTCGTCTGAAAATTACAAAATGTTTTAGTGACCGTTGAAGCAAAAACTCGGTCACCAATTTCCCGGCCAAGTTACTACGGGATTGTACCGTCTCTACCATATTTCTGTCTCAAAACATACTCTCCTTCCGTGCTGCCTACGTGGCCGCTCAAGTAGAAAACTCGGCCATCATTTATTTTCTAGGCCATGGCGAAAATATGTAAAATAGGCAAAGAATAAGCGTGGTGGTTAAAGTAATTTTGGGAAATGGATTTTAAAGGCACAAGTTGAAAAAATAAATCAGATGAAGCTAAATACACGCATAAACCTTAAATAGGCCATCAATTTTTTTCTCGGCCAGGTTCAATCTACAGGTAACCGTCATGTTTCTTGCTCAAATTTACACCCTATTCTCGAAAAATTTTTTTTACGTTGAGTATGCTCTCCTGCCTAACTCGGCAGTGGCCGCAATTAGAAAACTCCCGGCCACCCATTTTTTCCCGCTAGGTCATGTCGAAAATGCGTAGGCGATGTAATGGGGTAGTTCAAGGTTGCGTAATGAATAACCTGGAACCAAAAATGTTGTCAATATATGGCCGCCAAAAAAGAGAAAACTCGGCCAACAATTTTTTCTCGCCCAGGTAGGCTACCAATGAACGCTACGGGAACCGTCCCTATCTCAGGCTCAAAATTACGCCTTTTTTCTCGAAAAATTTTTGCATGCACTCACCTCCCGTGATTCTTAATTAATGTAAGACGTTCTTTTTTCTCTTCGTCTAACGTGTGTATATGCAGAATTCAGGATACTTGGTGCGTCTTCCTTTCGGAGTTCTTGTCTTCTAAGCGAAAAAAACGTCAAATCTCTGTGTGCGTTGTCATCGGAAGACTCGCCTTCGAAGAAGACGCTTATTAGCTCATTTCATCCACTCGCAAATGCTTCATTAATTTTGTGCTTCTTCGCCTGCCTTCCGACGTGTTTACTCACACCACCACAACCACCACTCCGTACCTCCTCACTCACCGTGGAGAAACAGGTTCTGGATTGTTTTGTAAGCTTTTGAGTTTTGTGTCCTAACTCACTTTTTAAGCTCCGCCCACTTCTTGGCCTGTTCGGTTTATTAGAATTTGTGTGGTGTACTACCATCTGAAATTCGATCCGAAAAATGGCAAAAAAAATTCAGCTGACTGATTTTTTTGAACTTTCAAAGGTTCAGTTTTTGCAACCTAAACCTCTCTTAACATTAACTTTTCAAACCCCGCCCAAATCTTCTTTTTCCAGAAATCCACCAGTAATTTTTTGGGCAATTTATGGTACAAAGCTATCAGAACAATTTTTACCGAAGTTTTTTTATTTATTTTAATTAAGTCTACTGAAATTCCTAATATATATTGAAAAATGCTTTGGATGATCCCGAAATTGGCCAAAAAACGTTGATCGATGGTTATTTTTTTGAACTTTCACAAAAGGTTCCGTTTTGTATTCAACCTTTAAACCCCCCCATTTCTTGGCTGTATTGTATTCAAAGTTAAAAGTTGTTCATGTTGTACTAAAATATGCAAGTAGCATAAAAAATTAATAACTTTTTAAGCTCCACCCATTTCTTGGTTTTTCTGGAAATCCTTCCTGACTACAGTAATTTTCTGGGACTGTTATGGTACATTTAGGTATCAGAAAAAAAGGATTCTTGGATTTATGTCCACTGAACTTGACCTGAAAATGTTTTGAGAATTCAACAATCTTAAATATTTTGATAAAGGTAGAATTTGTGTAAAACCCGCCCTTTTCTTGGCTGCCCAACCCAACTTTGCCCTTTGAAGATTTTCTAACTTCGGCCTGCTAAAATTCCAATTCTAGGCGATCTACCCTGATAAGAACTTACTCCTGAGTTATTGTTTGAAAAACATAGTCCATCCGTTGCCTAGAAATCCAAAACTAGGCCATCAGATTTTAGGTTCCTAGAATCACAAAGGCAGTTTTATGTTGTCAAATTTCAGTGGCATAACCTCATAATTTAGACCTATTCTATAAGGTCAGCCTATTTTTCTGGCCTAGAAATTTTCCTTGAGTTTGAGCCCCCTACCCCCACACCCACATGGCCTAGAAACCCAAGCCTAGGCCATGTGTCCCCGCATTCTCACTCACTTTTAATTTCTTAACCCACTTACACAATTCTCTCCCCCTTTTCCAATTTCGAGACATCGCGAACCTGGGAAAGCTCATTAGCTCATTTGTTGTGTGTGTGTGAGTAAGAAGCGGGGGGAAGGGGAGCCCCCCTTTTGAGTGGGCGGGGAGCTAGTATGGAAAAAGAGAGAAGGAGGAGAGCCATTTTGGATGGGTATGCAATGATTAGGAATCGAAATTAATTAAACAAACAACGGAATGAAAGGGGGGGGGATCACGGGCAATCGCCTGCCCTTCACTACATGTCCCCTGCTGGAAATGTGGAAATGTAAATTAACTGTAAATTAGAAAACTAGCAAAAAAGTGCGAACGTTTTTTATCGTCCTACTTGTTAATTAGTTTAAATTTCTATATATGTATGGTTAGACATGCCTATTTTGGCGTCTAAGGGTAGATGCGGGATACGGATACCATGGTTAAATGGGCGATGCATCATGCCAAATAGTAAATGCACCACTACACATTGAAAATTTAGCATTATATCCATATCACTGAAATTGTCCGGGGCCCAATCAATAGCCGCCGCCGACTTCTCAGGACTCCACGCGCCGTTATGTTTAATTCGCAGCGGGCGGAGACAGCTGGCCGCGCCCACAACGAGTTAAACCGCAGCGGCGCGCGGTACTCGTCAGATGTCGGCGGCCTGATATGATTTGGTTGGGTCCCGAATTTCAGTCTTTATTATTTGGAGTTCGCGTATAATGCTAAATTTTGTACCGTGTTAGGAATGGTCGATGCACCATGATAGTGCTAAATAGTCCAGCGTCTAGAAAACGTTGAGTACTGTTGAAACAGTGCAAAATAACAGTTCCGGAGGCGGATTCTAATTTCTTGAATTTTTTTTTTTCAAAAATTGTTTTAAAAGTAGCACTGTGAATTCCACCTCAAGCATTTTTGGTGTAAAGCAAATTTTTCACGCTCAAAATTTTGCGCAAATGGTTCTGAGGCTCCGTTGAAAGTGGATGCTCTTAATCAAGAAAGAAGTTAGTCCCGCCTATTGGAGGAACTGATCAAAACTGGGAGGAGCTTAAGAAGGTTATAAAATTTTGCTAATTAAAACACCCAGCTCCGCCCACTTATATATTAGTTGACTCCGCCCCACCCATTAAAAGTGGGCGGAGCTTAAAGATATTGACCACCTTTCTTGGGTGACAGTGCGTTTTAGCGTTTTTCATAGAGTAAATTTTCCGGCGGACCCCGGATCGATGCAGTCCCATGATTTGACGCGCAACGCCCGCTGGTAGTATGACGTCACTCGTGGCCGAACTCTTGCGGGGGAAACTTGTACTTACAGCAGTAAATTTCGGTGTCTCACGGAGCACCTGCACACGTACCGATCATGAGTGATGCTTCCCACCCAGACATACACATACACACAAACGTACTAATTAAGACAAATTATAGAACAAGTGGGGGGGGGAGGGGAGAAATTTACAAAAGTGTGCAGTGCGAGAGAACACACGTTAGAAGGAGAAGCTGCTCTGGGAGACGTGGGCATATCAGTTGGATTAGTTTACTGCTCTTTTCATGGGCAAATCAAGTGAGCTCCAAACATTTTGACTTTGATTGGGTTTGATTCTGAAATTTTTTTGTATATGGATATGCAGAAAAAATACGTTTCTTTTTTATTTTGGAATCGCACCAATACGCTGCGTTGCTACAGTGCAACTGAGCCGGTCGCATTTCTCTTCCATAACTTTTTTTCCTTCTAAATTATCAAAGATTAAAACTCATGCAAAAGCTCAATTTTATATCATTAAGGATTAGTAAAGTGTGGGTGATCGTCGAGGGGGATTACCATAATTCATTACTCATTTTTCAATTTTCAGCTGTGTTTTGTTTGATAACCTAGATGACCAACTAGTTTTCCCGTTACAGGGCTGGGACCAAAAAAAAAATTTGGACCAAAACACAAAAACAAAAAATTGAAGTTTTTCAAAAACCAAAACCAAAAAAAAACAAAAAAAAACAAAAGTATAATACCAAAAAATTTCTTATGCTTAAGTTGATTTTTAATGGGGTTAATCAAGTAATGTTGCAAAATGTATTAAAAAACACTATGACGTCACAACTGAGTTAAAATACATGTTTTAAAGTATTTTAATACATAATAGTTTTGCTCGAGTCGAGACTAGACATGGTGAACACTTTTTTGGATTTTTTTGGATTTTTTGGTCCCAATAAACCAAAAAAAACCAAAAAATCGATTTTTCGTCAAAATACCAAAACCGAAAACGACAAAAAAAAAAAACCACAAAATTCTCAGCCCTGGTTACCTGTCAGCAAATTTTCCCCTATCACCACTTCAGGAGTAATCAACACCCCAAAACGGCAATTATTTATTATTCTCCTCACCTCCTCAACACTCCATAGCGCCAGCCACCCTAATTTGATTGTTTAATTCGATTCAGGGCACCCCACCACACACAAATTTATTAATTTTTGGCTTTCTCGCCATTTTCCGTTAATATGCCCGGCTTGTGTTAGCTTTATTATAGAACTTTTTAAAGCGATTTCTTAGGAATTTGTGGGAAAACGTCATATGTGGCCTAGAAATTTGACGATCTCGGCCGTCGGGGTCGATGAACCATGTTGTGATGTATGAAAGGTGGCCTAGAAAATTTTAGGCCACCGTGATAGTCGTGGCCTAGAAATTCGGGCGCCTTCAGGTGGCCTAGTATGTGAAAAGTGACGTGTGAGTTCTTTTGCCGGTACGGTCAGGCCAATTTTCCAAATCCTTCGGAATGCTTTTGTTTTAATTAAGGTCCGTCCATATTCTACAATTTTAGGATCCGCCCATATCTTGGTTAAACATTTTTTTTGTGCTTCCTTTTCTGGAATATTCATTCAATCCATCATTGTTCTCAAAATTTGATGCACCATGTACTATATCTGTGGCCTAGAAAGCGCGACGTCACTTATGGCCTAGAAAATTGGATCTTGAAATGGGAGAAAGTAAAAAAGTAACCAAAGCCCCCTTCTGGACGGTCGTGGCCTAGAAAGTTAGAAGAAGGAGGGGAGTAGGAGATCGATCCATGTACAGCTGCAGCATTTGACGACTCGACGGCGCGTAGCTTTGTCGCAGGCCACGGCCATAAAAAAATGTATGAGATCGATGCACCTTGTTCGCGGACTAGAAATCGAGAATGTGGCGCATGTCACGCATGGCCTAGTGACTTTTACGGTTCAGGCCGAAACATAGGACGTGTCCTAGAAGTCATTCTTAGTCCAAGACGCTACTAAAAACTCTCAAAAAAGGTGAGCCTATGTGCCAGCCTACTAATCTGCCTACATTCTTGCCTACCTGTTACTGCAATCACCATGTTGCACCTACAGTACCCCCTTCCGCCCCCGTAAAACTTTTTCAACACGGCTCACCCAAAAAGTGCAGAAAACACAAAAAAACCAAGCCCAATCTACAAAAGCTCATACCCATTCGTGCTTGGATTAACAAATGCGCCACCATTAAAATGATAATTAAGAGTGTGATCGAGACTATTGTTGAAATCTGATCGGATTAAAAAGCGACTGGTCCGCGAATGAGCTTTTCATGCAACTGATGAGCCATTTCCTGTGCATGTACACTGATGATAAATCTCCCGATTTTATCTTTTCCGAGACATACCAAGTAATCTCAATGTTCTTCATTAGTTTCTTCATTTCCCGATTCTGGAATTAGTTGCTTTGATTTATTAAAATCTGTCACACCTTATGTCCATAAATCGTGATTAAATTTTTTACAGTTTTTTTTAAATATAGAAATGTGATAACTTTCCAACCAGGCTGTCCCAATACAGTTTTGATCTACAAAAAATGCCGGAAGTTTTTGCCCAAAACTCTGAGACGTCGGCACGTTCTTAACCATACAAAATCAGCTGAGAACTCTGCGTCTCTTCTCCCGCATTTTTAGATCATCGTAATACAATAATGAGAGAAAAAAATTTGAAAAATGAAAAACCTATGCCAAAAATTTGGCATTTCCCTCGGATTTTTTTTTTCGAGCCTAAGTTTCGATAAATTCTAGATTTTTTGAAAAACTGTCTGAATTTTTTTTTTTGAGAACAATGATTATATTGATTAAAGATCAGTGTTTCATGTAGCGTAGAAAAGGTTAAAAAAAAGATATGGGCAGAGCCTAAAATTACAGAAATTGGACCGTAAAGTTTTCAAAAAACTTTTTTTTTTTCAAAAACCGAAATTTTATTTTAATTTCAAAATTTCCGCTTCGGGGTTTCTTGATTTTTTCAAGTTCAATTAATTTTTTAGATTTTTTCCCGTAAAAAACCCAAAATTTACTGAAGCTTCACTATTGGATTAAAAATTTATAAGGTTTTGCGGGAAAATTAGTAAAAAATCGAAAATATAATTTAAATCTGAGAAAAATCAAAAGTAATTACAAAAAATTAAGGCTTCCATGGAGCTAGGTTCGCGTGGTGCCAGGCTACCCATTATTTTTTGTTTTGTTTTTTCCCCAGGAAAGTGTGACGTCAGCACGTTCTTTATAACTATGCTCAGTTGAAAAGTCTGCCTCTCTTCTCCCGAATTTTTCGAAGATCATACCAAGATGGGGCATTTTGACGCCACGTGTAGACTGTAGGCCATAAACCGCCTGCCTTCCTGATTTTCAGGCTACCTCCGCCTGCCTGTCTTTTCGCCCCAATCCACTCCTTATGAATATCTAAAACACATTCAGGAAATTCCTTAATTTGATTTTCACCACAGTGATAAAAAAGATAAATTAAAAATCATTCTCGTCAAAATGCAAAAAGAGTCGTAAGGCAGGCAGGTTTCAGGCAGGCCCTGGCTCACGCGTGCCGACGAGGCAGGTTACTAAATTTCGAAAATACCTTATTTACTCTACAAATCCTCTTAATACCCCGACATTACATCAAACCTATTAATTTCTGCCTTAGGCGATGGGACTACTAATTGATAGGAAAAGACGACTTGTGTGTGTGTGTGTTGAATTATGATACAAATTTGATTTTAGGCAGGTCCTCTTTCGACAAAAAACTTGTGTCACCACCCCACACCTCCCACGTTTTCGGTCAGTGAAGCTTCTGCTCGCTGTTAAGCAGATATTCCTAGGGAAATCATAAATCCATTCAAGTACTCTTTATTTTCTTCTCTGCGACCAAATTAGTATACAGATGTCATCATACTTTTTTGTTTCTTTTTGTGGGGGCTGTTCATTACAGTTTGCTCTACAAACGGGAATTTATTTTGCTTTTTGCCCAAAAGAATGTGATGTCAGCACGGTTAGCCGTAACCATGCTCAGTGAACTCTGCGACTCTTCTCCCGCGTTTTTTGTAGATCTAGCATTCCTGTAGATCGAAGTGGGAAACTCTGACACCACGTGCTTTGCGAAAAAATTTGAAAAAAACCTTTCTTTAAAAATTTGGCATTTTCAGCTGGGTTTTTTTTCTCTACAAAATTTTTTTTTGAACGAAAAAATGTTTCGATAAAAAGGTTCTAGATTTTTTGAAACTGTCTGAAATTTTTTTTGAGAACAATGATGACTTGAATATTGTAGAGAAGCGTAAAAATAAGTAAAACCAAAAAAAAACGCCTTGGGCGAAGCCTAAAATTACAGAAATTCGACCATAATGAAAGTTCCCAATTTTTTCTTCACAACTTTTTTCAAAATTGCTGAAATAACCCAACTATTAACTTTAAATTTAAATTTCAGAAATCCTAATTTTGACGCCGATTTTTACAATTATAACCTGGATTTGTTTTTCCTGCAAATTCTTTTTTAGCAACTTACAGTTGGTCGGTTTGTCGATAGAGCGTGCTTATTCACCAGGCGCTACTTCCAGTTTGTTCTACAACAGTGCGGGACTTTTGCTTTTTGTCCAAAAGACTGTGATATCAGCACGTTCGTAACCATGCAACAATCAGTTCCGCATTTTTTGTAGATCAACGTTGATCAAAATGGGGCACTGAGACGCTTTGGGGGGCGTAGCGGGCCCTTTCTCATTCCCGAAAGTGCTCTCTGTTATGAGGTCTCCGTCCACGCTTTATGGATTCAACTTTGTACAGTTCACACGAGCACCCACGACATGATTATTCATACAACATTATACAGAACTAACTATTCGAATCTCAACATGTCTTCTTGCCGAAGGGTTTTTTATCAACTTTGACTTCCTTCTTCTTCGAATTCTTTATACAACTACTCATCTTCTAGTTGCCCTTCTAGTTGCCTCACACAAGCAAAATTTCTTTTGAAATGAATAAACTCTCGAATTGACTAGTCAAAATTTCATCAATTGCTCCTAGAGAGAAGTCAGTCGACGTGTTAGACTTATTTGGCAGATATAAAGAGAGAGGCACCGAAAATGAATTGGGTTTAACACAACAACGCGTAGATGAGTTGTGTGTGTCAACGATGCTGAAGATGATGAAAAGAGCAGAGGAGCATGAGTGATTTCTGGCGGTCGCGGCGGATGAGCATGAAGAAGGCTTACGAGCTGTATGGCGATGCGGCTAAAAATTATACGATGATTACTGTAGATTTGGAGCTTTACACCGTTTAATACGTACATACAGACTTGTTTTAGAATATTTTGTATTTGAAGCTAATAATACAAATCGCCCGTGTGCCGATTTGTCGGAAATTATTCCGGCAACTTGAGGGCCGGTTTGCCGATTTGCCGTTAATTTTCAATTCCGGCAACTTACCCGGTTGCCGCTTTGTCGGTTTACAATTTTGGTCGCTCTCAAACTGCCGGTTTGCCGATTTGCCGGAAATTTTCTTCCGGCATTGTGCCGGTTTTCCGATTTGCCGGAAATTTTCAATTCCGGCAATTTTCCGGTTTGCCGGTTTTCCGTTTGCCGGATAATAAAGTTTAGAGGGATTTTTTTAGAAGGAAACTCTCTGTGACTTTTTGAAACTGTTGCCCGTTTTCTTTTGCGATTTTTTTTCATAGATTTTGCAAGAATGCGTGCAGCTTTGCCAGTTTAGACGTAATTGAATTTCTGAAATTTCAAAAAAAAAAGTGAGCAAAATCATAAATTTTTGACATTCATTTTTTCCGGTAATTTGGCGATTTGCCGGAAAAAATTCATTTACCGCCAACTCCGAATGGTACGTCTAACCGCAAAAATTTAGGCTTTTGCTCTGGAGCCTTTTCTCTGGCGTTCTTTCAAGCTATCGTAATGTGACCACACACCTTTCTATAAATTTCAGTATTTACGCCAACCGAGAAGATCACACTAGTTTAAGGTTATAGTGCAGCTGCTCAATGGATCAGGTCTCTTACCGGGAAAATATTAACAGGCCGAAGTGACTGTGAAGCTTCGTGAAAATTTTCTGCCGTAAATTGTCAATTTTCTGCCGCACTTGGTCAATTATCTCATAAAGGTCACTTAAGTTAGCCAAACCGTGAGACAAAACTGCCCCTTATTCCTCATGCCGTCGGAAATCTAGAGCAACCCTGTATTCGAGGTCCCAATCTTTCTTCCCCCGTCTATCTAACTTTTCCTAACTACATATAACGGAGGACCATAATAATCCTAAATTTGTCCTTAGTTTTCTCCCTCCTCACCGTCTTCTAGTTTCATCCATGTCTCGCCTCATTTCACCCGATTGACGATCATCTCGGCTCCACACTTTGACACCATAGCGCGAATGAAAAAAAAGAGTCAGGCAAAAGGGGAAAAAATGCCGTTTTATTAGGAGTCAAATAGACACCAATACACACACACTCAATTTTAATGGATTAAGACGGGGCACGATTTGACACCATCGACACCAATTTGGATGGGGGCAAATAGATACATACACAAAAGGAGTTGTACCACTAGTTTTGGATCTAGAAACATCATTCTAACATCTTTTCATTTATGATTTGATTTATGCAAATGTCCTTGATTCGTGACTTCTTGTATAGTAGTTTGGATATTGTAGTATAATCATGGTAGTTGCTGAAGACTAAGCTCTTTAGCAGATTTAAGGTATGACCGTAGACAGTTCGGGATCCCGGCTTGTTATTGTGTCAGGTCCGGCCCAGGTTGTCTAATAAATACAGGTCTGCTCCAGGACGATAGCATCACTAGAATAACGGTCGTTCCGTGACTTTGTAGTTTGAGCTTTGGTCTTTGGTCTTTGAACTCTGTAGTTTTTGGTCTCATCACACAAGAGAGGTCACATAGGCCCGGCCCTTTGTGACGTCACAAATTGGCGGGAAAGTCAAATTTTGAGAAAATCGATTTTGGCGGGAATTATATAATTTAGATTTTTTGAAAACATTTTGGCGGGAATTCAAAATTTATCAAAAACATTTTGGCGGTAATTCAAAATTTAATTAGACACTGTTCTCGGTTCGGCCCAGATATAATCATCCAACAAGTCTTTCTCAAGACCACTCTTCAACACATCAGTTCTACTGTTACCAGCAAGACTGCCGCTCCACACCCTGTATAAGGGCCCTAAGGCTCGACTGAGTTTGATGTAAATCTTGCCAAGCCTGTATCATACCTACCTAGGCCCATCACAGGCGCATCTCTCACAGATCTTCCACAGGTGTTTCTAAGTTGCAACAGATCTGCACCAGGTCTGTTTTTAGCCAGGTTTTGCCTGGGTGCAGCCCAGTAGTCTACCTCTAAACTATCAAGCAGATCCTGACACCAGTTCCTAGGTCTCACATTCATCTAGGCGGATAGTCTACCTAGCTAACGCTTCAACCTCCACTGTTTTAAAGTCTTACCCTTTCTCAAACTTCAACTCATTAGTACATACATATGTTATTAGTAAATTCGCGACTCACTAATAACAATAATTCAAAGCCTCTTTCCTGGCAATGCTTCCGGTACTGAACACGGAGAGAGCGCGAGGTGGCAGGTATCCGGTAATTTGTTAACTCGAGCGCCGCGCACCCTGGCTTTAACCCAGAGCAAACAGCCCCGATGATCGCTCATGCACGAGTCTCTTACTCACGAGGTGGTGGTGAGAGGTAGGTTGGAGAAAGCGGTTCTAGCTTCACAAATTTCAATTTCAATTTACTCTCGCTCCGTTTGACTCGGGTCCCCCCCCCGCCCTCAATTTTTCGCCCCAAATTGCTCCTTTAATGGAAAGTGTTTGAGTGTGTGAAAAAGAGAGAGAGAGAGACACCTTCGGGTCACGCCAATTGCACTAATATGTGCTCTCCCATTCGCATCCTAGAGCTAAGAGGTTGAATAATTTTCGAACTAATTCGAGGAATGTCAGGTTTTTAGTTGGTCCTAACTCTTTGGCCTAGAAATTTAGAGTTCTAGTGGGGTCGTCCATCTAGATGCGGTGGTCCGAGAATCCTAGGCTTTAGTTGCCCAGGCCATCAGGCCTAGATTCTGAAATGTTGTGATGCTATTTTCCAACTTTGACCCAAAAGCCCTCTAATTTGTAGGCCATGAATCTAGGAACCTATAGGTAAGGCCTGATCCTTTGCTTACTTGCCAATAACTAGAAATCAATGCCCTAGAAGCTCGCAAAACTTTCCTAATAATTTCTAGGCCACCAATTTTTTAAAGATAGCAAGTCATCAACCAAAAATTCACGGCTCAGAAATGAAATTCGCTTTTAAGCGCACCTCTGACTTCATAGCAGTGGCCTAGAACGCCAACCGTCAGTATGTAAAAATGAGCTTTTTGGGCCTCGAACAGAACCGAACGGGACATGGAAGCCTAACATTTTTAGGCCACTGACTTTAAAGCAATTGCCTAGCACCCCGTTTTTCTGTTAGACAGCCTAGACTATCATCTAGAAATCATTGGCCTAGAATCCTAAAAATAATTCGGCCACCAGAATTTGAATGGCCTAGAAATCTAGTTGAATTCTAGGCCACCATTGACAAAGGATTGGCCTAGACTCCCTAAGAATGTGATTTTTAAGCTACTAACTATACCCTAGACCATTGTTTAAAATTGAATGGCCTAGAAACTAGAATTTTTGATTTTTAGGCCACTACCTGTTGTGAGCGGCCTAGACTATTATCTAGACCCCAATGGCCTAGTTTCCCCGTCCGCTGAAAATGTGTTTTTTCGGCCTGAAATAGGCCTAACATATTACAGTCCACCAACTCTTTTAAGATGACCAGTACTATAAGTTTAATCCTAGCTTGCCACTATAAATAATTGGCCTAGAAGCTCCTAGGCCACCATCTAATAATCGATGGCCTAGAAACCTCCCATTTTTTGTATCATAGGTGTCACCAACAACCACTGATGCCCAAGACCCGGGCTTCTCATTTCATAATGAGCAGCAATGCAAATGAGCTACCGTACCACTTCTACACACTGCCACCCTCCTTGATCCACACCCATTTCCCCTGATTTCTCGTCAATTTAAGCGGCGGCGGTTCACCACGGGATAAATTTGTGAGAGGTGAGCTGCTCACAATAATTGTTGTGAATAGGCGGCAGTGGTAGTGGTGTTAATTGTGAGTTCCCAAAGTTCACACAAAAATTTTTCGCCGCAATTGTTATCCAACCAACATAATAATAATAATAATAATAAATGAGTGTGCATAAATGTGCCCTTTTTCGCTCCACACCCGTCCTGATGGGGACGACGCTTCGTTGAATAGTTGGAATAATAATAATAAATTTGGTTGGAAAAATTTGGGCGCCCCCCTCCTAACACCCTCACACACACGAAATTTCATTTCGCGCGCGCTTCGAAAACATATTGATGACATGTTCTTCGCGAGACAAGTTATGAAAATTTGTGGCAATCGATGTGGTCCCCGCCGGCTTCAAATTTAGAGCAGAAAATTTGTGCTCTAAAGGTGCCTTTTAAATCAAGAAGGGTTACACATAAGAAAGTTTGTCGGAATCCATATTTTTGTAAGGTCCTTGGACCTGAACCCCCGGTCTTCAAATTGTTAGGCATTCTAGGTCTTCCATGGGAGACAGGCGTTTAGGCGTGGGCCTCGGCCTCTCGCCTCATTTCTACACTATGGCGAGAAGACAAAGGGCGGGTGCTCGACACTTTGTGCCAGATCATTTCGGCGTGATCTACCTTGATCTACAAAAATGCGGGAGAAGAGAAGCAGAGTTCTCAACTGATTTTACATGGTAACAGCGTGCTGACGTCAAATTTTTTTTGGACGAAAAACTTCCGCATTTTTAGTAGATCAAAAACCGTAATAGGACAGCAGGGCGTTCCACTAGAATAATTCCACTTGTTCATAATAAACGTATATTTGTCAAAATCTTGAGAATTTCCATAACTTCAACGAAAAGCACTGATAAAAGTGGTTCTTTCGCCGCGGCCGACACTTATCGGGTTCCGCGCCTATAAAGGAGACGCGGCGCGCGGCGCGAGGCAGGCGTTTTGGCGCCTGCCCGGATGCCCTACACCAAACAGCAAACATTTCTAGCTCCGTTTTTCGGACTCTACGCCTTAGTCTTTTTGTCACAACTTCGCTACACTGTGTTATTCTTCCTTCTACGACTTTAAAGGCGTGCGGAATGCGACTCACGTGATGTCAGGGAGTCTCATTGCGGTTTGATCTCAAAAAATGCGGGAAACTTTCCACCAGGAAATTGTGACGTCAGCACACTCTTGCGAGATCAGCGTTGAAAAGTCTGCGTCTCTTCCCCCGCATTTTTCGAATATCAAACCAAAATGGGACATTCTGACACCACGTACTGGTGACTTTGGATCAATGTAGATCGTTTTATAGGCCATCCATTGTTTTTAGCTCGTGGCCATTTTAAATGAATTTCCAAAATTTCCAAACACCTATTTTTTTGTCAATTCACAAGTCCCCCACGGACCCCCTCCATTGTTCCCCCGTTCACAACCTCCCTCGGTAACCACCCATTTAGCGGGAAAAAATTAGCGAATCAGTGACTCATAATCAAGTAAACCGGTCAATGCTCTACGAGCAAGAGGGGGGGAAAGGGGGTGGCTAATCGAATTATACGGGGGAATGGGATCCCTCCGCGGACACCTCGCTGCCAATTAACAAGTCAACTACTTGGGGGGGGGGGGCGGCCTCCTCACAACAATTGTATTATATTTCTTGTTATTATGATTATTAATTATTATTCTTATTAGAAATTAGTTTATGAGTATATAATATCAACTATAAAGATGACAGTTAATAATAATTGAAGTCTTCCAATAGGTGGCCATTAGAGAGAGGGGTCTGTAGTAATAGAAGAGACAAGGCGGGGGAGAGGGGCCAAATAATTAATCTGGGCCCCGTGGGCTCGTAAAATTCCGATAAAGTTGCTTGTTTGTAATTAGCTAATTCACTGAATCTTTTTTTTTTGTTGGGGTCTTACTATGTGTTTGAAACTTCCTGTTATAACATGTTTCAAAATAGACTATCTTACCTCAATGGGGACTTACAGAACCCTGGTGTTGAGATTGCTAGTCTAAAGGGTTAACCAACCATGGACCAAAAATTGCAATTTTTGATTTTTCTTACTTGAGGTTCTATTTTTTTGAATACAACGATCAGTAAGGATCTATTTCGATTTAGCAAAAAAACCTAATCAAATTTTGTAAAAATTTTCTAAAAAGTTATGAACATTCCACGTTCACACATTTCTTGCTTCCCTCATAACTTGAAAGTAAATGGAAGAGTTTTCGGCGAACAAGAGCCATGCGTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTTATGCTCCGTGTGGGGTCCACGACTTCCCCCGTTGTCCGCCAGACGATTGTAAATGGAGCCCGAAAAATTCAATGAGGAATACGGGCCAGAACCCCGTGCACTTTTTTGTTTCTAAAACTGAAATAATTTTCAATTTTGAAATTTTCCTTGGTTTTACAATATACAAAAGCTTAAGTTCGCAAAAATTTTTGACACTGGTGGGGGCGTCGAACCCCTGAGGGGCATCCCTGTTAGCCACTGGGACCCGCCAAATTGCTAAAACTTCAAAACAAAAATTTTAGACCTTTTTTAAGGTTGCTTTCCTAATTACCGACGTCCGACTTTTCTAAAATTCCTATTCAAAGTCTTCGTAAAACTAAAGACTGGGGGGCTCGAAGCCCGGTCATCATATGAGTAGTCATCCCTGTCAGCTGGACCAATACACCACTTGCCCCCGATAGACGTGTTTCTGGTCTGTTTTACGGAGCGTGGCCTAAAAAAATCAGCCACCAATTCGAAAAGTCCATAGACCAATGTCAGTTAATATAGAAAGTCGTCTTTCAACCACAAATTCGAGCCAACCAACTAATATATAACCTATTTTCGCCGTGTTGTTCCTGTGTGTGTGTGTGCCCCTAGTTAGGCCTACCCCCCTTATGCGCTTTACTTGCTTTACAATTTCGATTGGCCCCCACACAGTTACGATCATTTTGTGTCGGGTTAATTCGACATATCGTTTAAACGGGTTACCTCTCTCGGGGCCCCCTATTCTCCTACTTCTTATTTGCTCAATATTTGCGCGTCGAAATTTCTTCTGCGATGCCCCAAATAATCAGATTCACCAATGTATAAAATAGTGCCACGCCTCACTTTTTCCACACCCATCATCTCAACTTTCCTCTTCTCAAATGCCTAATCAGCCAGTTATAACGAGGCTGCTCTTCGTGTGGCGCCCCGCACATTTTATTGCTCCTCTCACGCTTCATTCTCACTTTTTCTGGGGATCCTTTTTTTTGCAGACCTAAAAATTTGAGCTCAGCCATATTTTTGTAAATATAATCAAAAAAAAATAGACATTAGTCAAAAAAGTTTAAGCCTAAAAAAATTTTTTAGATAAAAAACGTTTTTAACTTTTTACAGTTTTTCAGTGAAATATTTTCAAATTTTTATAAAAAAATGTTTTAAGCTTATCTAAGCCTATGAGCCTAAGCCTAATAACCCTAAATATAGTGTGGGAGCTCACGCTCCCCCACTTAAGCCAAGCCTAAACGCCTAAGCCAAAGCCTAGGCCTAAGCCTGGCCCGAAGCTGAGACCTAAGCTTAAGCCTAAGCCATAAGACTGAGTTCAAGCCTAAGCCTAAGACTAAGCCTGAGTCTCAGCCTAATCCTAAGCCTCGTAAGCCATTTTTAAAAAAAATCTTCATTTTTTTGCAATTACTATTTTTTCTGAAAATCAAAAATATCGAATTTTTAGAGTTGCTATAAAATTTAAAATAATATTCAAAAAATAATCCGAAAAAATTAAATTTTTTTTCTCAAAACGGAGATCATACAGAATCAGCTTTAAAAAATTCAAACCAACCTATTTTTCGTTTCAAAAATGTTCAGAAAATTTGGTAAAAGTTTTGTAGAAAGTTTTCATAAACTAGCTGTTGAATAGGGTTTTAAGTAGGCGTTAAAACGCTTGCCTGCCTGACCTTCAGGCGACTTTCGCCTGACTGCTTGACTTTCAGACGTTCTCTGCTGCCTGACTTTAAGGCGACCTCCGCCTGCCACTCGCCTCAAGGGTATCCGAACCTTTTCTCTTAAAATGTTTGATAGTTCTTCATCAAATTGCTAAAAATACGGAAATTCCAAAATTTTGTAAGTACATGAATGCAGGCATCTGCTGTGGCCACCCATAGGCCTCCGACTTTCGTTCTACAATTGTCGTTGCCGTTTCCTTCATTTTCATACCCCAAAGTTATGATTTTTCTTACACCCCTTGCGCTGCTGCTGCTTCCGCTCGTGATGTTATGAACCAGTAGTCAGAACCGCAGGTCGAGAATCCCCACAATGATCACCCAATAAACGGGAAACATTAGCAAAAACGTATGCCCCCGTTTTTTTTTTCTGAGAAGTGTCGGCATCCCCCTAACATATGCGGGGAACATAGTTCGCTAAGTTTTGTGTGTTCCTCCAGCTCCTCCATATGGTTACCGTAGTCCACTGGTGTGTAATTGTTGTTGTAACTATCCCCCGAATACCTCTCCTCACATTCATTCACAACACAGGTGTCAACTCAACTCTCAGTGCTCATTTGAAGTTTATGAAGGTTAGCTTCCGGGGATGGCTCTCCTGGGCTCCCCCACGAAAATCAGTTAATTAAGCAATGTGGTGGTGGAGGGGCGAGCTGCTCGCTTACCCCCCCGCCCCGATTCTCTCTCTTTCATTTGTGACTTATTAGATTTTAAATCACGTCTCAAACTTTCCACTTTAACTTTCGCGTTTTTTAAATTTTTTTTTCACTTTTTCCTCACAAATTCATCCAAATAAGTTTCCAGAGTTGTCCCGCCCCATACATTTGCTAAATGGTAGAATGGGATGTGACACCTTTGACAATGTATTTGACAACAACAAACCGCCGACAAGTTCAGAGTGTACGGCGAGTATGAGTTTGGCCGGGGGAAGGCCGATAAGTTGGCCAAGACTTCTTTTTTTTTAATTTTCAAAGGTCGTTACCTTCGCGACGTTGTGCCAGGTTGTCCCATTGCTTTTTGATCTACAGAAAATGCGGGATATTTTCCCTAAAAAATGACATAAGCAAGTTTTTAAATCTTTTCTCCCGCATTTTTTTGATCTTCGTGTACCAGATCATACTCTGACACCACGTGTACCTTGAACCTCCTGGCTCCGTTTCTGAAGAGTCGTCGCTAGTGCGCATTTCTGCATTCTCAGTGGTATTTAATTTGTACAGTACCGCCAGAATCATGTAACGCGCCGCTTGTAGTCTAGTCGTTACTTCAGCTCTAAACGATAGGTCCGGGGTTCGATTCCTTGCAAGTATCCATGGAATTCCTTTCTCAAGATGGAGGTACATATGTGCTTAAAATGTGCACTAGAGATCGCGAAACTTAAACCATGGTCCGACATGTACAGGGTTCCGCGCGCACGCCGACTCGGGCCTCCAAAAAACGCCTGCGGTTCCAGCGGCGACCTCCGCCTAACTCGCGGCGCTATGCCTTCTGTATACGGCCTTCTGTCTTCCCTCATAAATTGAAATGGAAGAGTTTTTGCCGAACTAGGCCATCTTGGGCTCGGTATCTGGTCTCGATTTTAGTTGTAAAAACTAAATTATTTGTCCGTGTGGAGTGCACGACTTGCCCACGCGTTGACCGGCGGGCGATTGCCAATGGAGCGCGAAAAATTCCATAAGGAAGAACCCGTGTATAGTGCCGCGCGGCCCGAAAAGTGTCAGCCGCGGCGGAAACATTCCATAGGAAAACTAAAGTTCTCACTTTCAGAAACATACCAATGATACCAGATTCTGCGGAGATAATGCGACTTGTTGCGGATCCTTCGACGTCTCAGATGTTTGGTAGGTCATAGATCAAATTTTTTCCGCAATTTCCCGAAGATTTTCAACGAAAACACAAAATGTCGGACGAGATCTCCCCGCGTCAGGCTTCGACGAGGCGAGCCTCTCCTCCTCGTTTCCGTGCGATCCGACGCTCGGCGCGTTCGCCGACATTTCCCAATTCTGAAACATCACTCCGAAATTCGTCGAACACGCTGAAATGTCCAAAGTGTGGCCCGACAAGTACCAGGATACCCTCGAAAATGATTTGAAGGAGAAGCACAACGATGTGGATGTCAAGTGCATGTTTTGTGCCGAGAACCGTCCCCACCCGAAGCTTGCTCGCGGTGCGCGTACTCGTGCGGTTATAAGTCACCATAATCCTTCGATGCGAGTTGTGTCGGTACAGTACGACGAGAAAGGGCGAGTATTCATATGCAAATAAGCATCTTCATGGACACCAGTTCAAGAGCTCCCGAATTTGTAGTAGTAGGTGGGGCGGCGAAGGGTACTGTAGTTTTCGTGGTCGGCCCCAAGAATTTGTTTCACAAGAATTTAACTGTAGAACTCGAACTTTTCGATTCTAAGGTCTACGCAAAAACACATACGCCAACTTTTTTGAACCCTAAAAAATGATACTCATTAGAGTTCTCAGTGAGCAAAATTCGATTTTACAGTTTTTAATTTGACGGTACTGTGGGTCTTACACTCAAAGGGTTCTATAGTTCTCGTGGTGGGACCTTGTCAAATGGACGTGATTATATTTGGTTTAAAGCCCCTAGAATTCTGATTTTTTTAATACATTGGTTTTATTCTGAAAAGACTGAGAAAATTGAGTTTAGTCGAAATCAATAAAAATCGCGTCGAGACCCAAATTTCCCGGGTCTCGGCACGAAAATGGGGGAGAGGGTACTGTAGTTTTCTAGTCTTCTCTCAAATATCGAAATGGTAAAGTTTTTGCCGAACTAGGGGCCATATCTGGGATAGATTTACGGAGTGCCGCGTTGCACTGTGTAATGCGCTTGGGCTCAATTTTTGTTTTAAAACATGAGGAAGACCACAATCTGTTTTCGTGGTGGGACCCAAATGGGTCATGATTATACTTATTTGAAAGGCCTTAAGAATTCATTTAAGATTTTTATTATTTTAATTTAAAAATATCCTTAATTTTCCAATTCGCTAGGAGACAACTTCGCGTGTGGTGCTCCAGTTAGCCTAAGTAGTCCAAACGAAGAGCCCGACGGATTCCTGGTCTGCTATCTGCGGTATCTTCACCTCTATCGCCGAAATGATGGCACGTGGAACAAGACCGTCCCAAGACGTTCCACGGAGACGTTACCGTCCTAAACGGGCCGGAAGTGCCACTTGTGCCCGTAAAATACCACATTGAAAGCCAATTTTCAACTACACACAAGGACGGGGGATAAGCTTCTGCAAGAAGGTTCAAATTGTGAGTTTTGTATTCCCCCCTCATCATCTTCTTATTTTTAGGCTTGTGTCGCCCTTTTCCCATTTTTGTGAGTGTCTGTGTGTGTATGCGCACCGATTTGTATACACATAAATTCATGATTTAATAGCGTAGTAATATTTGCTTTGCCACTAACAGTTTTCGTTATTTTAAAGCCTTTTTTCTACTATTTTTGAAAAAAAAATTTAAAAATTTGAACCTTAATATTTCCCTAAAAGCTCAAAACTGTAGTGATTTAAATTTTGAATTCAGTGCTGAGACCTTTTACCGTAGTATAATCATTACTAGGTTTTGGTTCTGACGAAAGTGTTCGTTTTGGCGGAGCCCAAGCAAGGCGTAATTGATTATAGGGTCTTTGCACGCAAAAAATTTAAGGTCCGGTAGGCTTGGAGTTTTTCTTGAATTATATTAGTTTCATAAATTTTCAATTTTTTTGAGTTAATTTTACTCTCCCTTCCCGCGGTCGTGTTGTCTGATCCTAAACCAAGCTCTAGGCCTAAGCCGAAGCCTAGGCCTAAGCCTGAAATAAAGTTTAAGCCAAAGCCTGAGCCTAAGCCTATGTAACCCTAAGCCTCAGCCTCACCCTAAGCCTAACCATAAGGCTAAGCCTGAGCCTAAGCCTGAGCCTAAGCTTTAGTCTAAGCGTAAGCCTAGGCCTAACCCTGACCCTAAGCTGGGTAAGCCTAAGCCTTACCGCCTAACCCTAAGCCTGAAGGGCCTAAGCCGCCTGCAAGCCTAAAGTCTTCGTGAGACGCAATTATACTCAATTGAAAATGAGCTCACTATGAGCTGACTTCAAATTTCTCAATCAAAATGTGAAATACTTTGATTTTACGGGCGGTGGCTTTACTGGACCCACCGAACTTAATAAACTCTGAAATTTTTTTTTCATTGAATCCGGTTTCTACTCTCTCCGGCTATTTGTAGGCTGTCTTTCACTTCTTTGTTCTCGTCTGGTTGTTCCCAATTTCTCGTTCAACCCTTTACTCATTCGCCCTCTCATTTTCCCAAATCCTATTAGTTATGGACCTATCGGGGGTGACGGTGACGATTCTCGCCATTAAGACCCCCCCCCTCTCAGAACTGGGCCGATTGAGATGGAACAAAACAAAACTGTCAATTTGAATAAATTTGCAATTTGACGCGGGCGACGCGGTTACCGAGAAGGATATAAACTGGGGAACTCTACTTAGCCCGTAAGGTGCTGCTACTATTTTATCACATCTCAATTTTTACGGAATCCCGTAAGGCGTTGTCTGCTGCTTCTCTGTTTTTGCATGCTTTTACAAGTTCGGCCCGTCCGATGTACTCGGCTCTTTGTTTTGCAAAACAATTTAAAATTTGAGCCAGGTGTCTGCTGCTCCGGCTAGATTTCCAATATTTAAATTTTGCGCAATCCTGTAAGATGTGGGGTGCTTGTCAGTTTTTACAAAGTTTTTTCTCTAAGGCCCGCGCAGTGTCGGCTGCCACCTCGTATGTTTCATCAAGCTTGATCGATTCGAGCCCGTTAGCTCAGGGCCTGCGTCTTTTTTTTTCTCAAAATTCCAGCCCGTATCTTTTCGGTTGCTAAATAAAGACAGAAATTATTACGAAATTTTAACGCTTGAAGTGTCGGCTGCAAATTACACTCATTAGATTCCCTGTCTCTCCCTCTCCCTCTCTCTTCATTGGGGAGTGCTTCTCCCGAGAGAAAATGACTAAAACTGTCAATTCGAATATGCACACAGCGGGAGATGTTTTTCTGTAACTCCAGACTCCACCGTCTTCTTCGAGTGTTCTACTGCCTATTAAGCGATGATTAACTAGTCGTTCCCTCCCCCTCTCCACATACCAATAAACCTGCCAAAAGTTATGTCGAGTATGCTTTGCTCGCCATCGTGCCGGAGGCTATTTTTTCTAGACTATGATGTTTTTTGGAAAAACATTTTTCTATGGAACGATGCAAGCTAGTGCCGTGTTGCCGAGTCTTCAATTTAGGCGTATCAATTATGAGATTTCAATTTTAGTCCCTTGTATATATTATTTTTTTTGAACATTAAAATTTGATAAACTGTAGATACCCCCTAACTATTTATTTTTGTGCCAAATTATACTATACAAATTGACTTGACTCTAGATGCACCCTGACTTTTTAACCGCACTTTCGAAGATCTCATATTGTCGCCTAAAATTATTCTCAAATATTTAAATTTAAACTTTAATCCTTTATTTTTTTTCATTCCTCGGAAAAAACCCCGTTAACAGAATTCCCAATCTGGCCTCCAGTTGGCGCTTTTGTCGATGCACCATGTTCAATATTTTTTCAAAATTTGGCTCATTGACCTGAAATTTTGTCATTTTTTTATGTTGCAGGGTTTATTTTGCGATTTTTGCGATGACAACCACATTATGTGGATTAAAAAAGTTTGGAATCTCGTTTTCCCGTTTGGCTTCCATATTGCTATGTAGTTGATGCACCATGTCCAGCTTTCTGTTGAAATTTTACTTTTTACATTTTTTGCTCGCTTTTTTAAAATTTAGTTTGACCTTAAAATTTTGTCAGTTTGACAGTAAAAATTTGTCAGTTTGACCTTAAAATTTTGTCAGACATATAATTTTTTTGTGTTTTTTGTTTAAAAAATTGAAGGTTTTTCGCGATATTTAACATATTGCATGGAATCTTTTGATCGTCTCTAATTCGTGTAGCAAGTCGATGCACCATGTCCAATTTTTTAAAAGCCATTTTTACTTTTTTTAAATTGTTTGCCCAGTGGCTCTTGACCTTAAAATTTTGTCCATTTTCCCTTAAAATCTTGTGTTTTACCTTAAAATTTTGTAAGTTTGTTAAAATGTTTGTTTTACCACAATTAAAATTTCCGAATAAACTTTTCTGTTTTTTGGGTTTAAAAATTGATTTTTTTTGCGTAACACATCAAATGGCAAAAAATCATGCACCATACCGGGTGTAACTTTATCCGAAAACAGTTTTCCCTAAAAGTTTGTCAGAATTATACATTCTAAGTTCAAAACCGTACGGAAAAATTAGAACCCATGTCGACGCACCATAAGCTTTGGCCCACTGAGCTTCGTTGCTGGTCCTGCATATCTCTTACCCCCTCTCGCCGCTCTCATAACATTGACCAATTAATTGGGCGGAGCGCCGTTTGGAAATCGATTGGCTGACGGGCCCGCCCCGCCCCCCGTCCCGCAAATTTTCGAAGGAGCTTTGGACTGGACAGACACACACACAAATTCACAAATACACGCCAATTTGTCGATTTTTCTTGAAAATTTCTTCATTATTGTATATTTTTTTGTGTCGTCCTCTTGTCATCCGCCATCCTCGGCGTCTTCTTTCGTTTGATTATTTCATACACCTACCACGTAATTCGCCTATTATCCGCCTCGTTACCTTCATCTTTCGGTCGACGTTGACGTGACATCGGCGCTCCCGAAATGAGAGGAAATAGGGGGGGGGGGGGGGGCGGACGACGGGCCCACTACGACAGATCACGATCATTTTCGTTCTATCATCTTATCCGGCAAACCGTCGTCCCCCTCCATTTTTCAACTTATGTAACCAAAACTTTTCTTATCTTGGGATTTGGTCCCCTTTTATAGCAAATGCACTGAATTGACAACATATTAGTTTCTCACTTTTTCGAAGTTTCACAATTTTTAGTTAGTCCGTTTTTTCAGTCTGGCCGAGTTTTCAATTTTCCCCGGCCAGGGAATCTAGTAGTATTCACATAATTTTTCTTATTTTTGGTTTTCTAGGCGACCACTCCCTATTCTAAGCCCGGCAAACTTCTAGGTCCCCCATTTACACCTGACTTCCTACCTATCTGAAATGCCTACTTGCCTTCCACCTGACAAAGATGCCTACCTACCTAAAACCTTCCTACCGAACTATTGACTCTTACCTACATAAGACTTGCCGATCTGAAATACATGCCTACTAAGACATGATACCTAGCCTACCTATCTAAGCTACCTACTTACAGATAATGTACCGACACAAGACTTGCCTACCCACGCACGGCATCATTTTTACCTACCTACCTGTACTTAAGATCTAAGACCTAGATCTTAGTACATAAGAATTTTCATCTTAGATACCTACTCAAGGTCCTGCCAAAGATGCATGCTTACCTATGACCTACTTACTTAAGATACCTGCTGGCCCAAACCCTACTACCTACATGCGCTAGCTCCCCCACCTACCTAAGATACTTACTTACCTATACCCGATTTACCTACACAAGACTTGCCTACCTAGGGCCGCAAGGCTTGATTTTCTTATTGTTAACCTACCTACCTAACTATAAGTACGATTTAAGACCTAGACGTTATTGCAAGACAGAGTTTCTGTCTTAAATACGTACTCAAGATCCCCCACGATACCTAGAAGCACTTCCGACCTAAGATGCCTCCTAAGCCCTGTCTCCCTAAGACCTAAGTGTCCTATAAGAACTTCCTAACTAAAAACACCTACCTAAAATAAGCCTTACGCCAAGCTCAAAAATTTAGAGCATCTGCATGAGATAAGGCTGAAAAATATCAACGAATAATGGAGAGCGATTATGTTCCTGCCCTCTTACTAGAAAGTTCGGAAGTAGTCGCCGCAAAACGCCATTACTATTGCTCATCGAGCCATTTCCGGTACTCAGTACTTTCTCATCCCCCACTACTTTTTTCGCACTCTCTTCTCGATTTGATTTGCATTCTTTTTGCCCTCGTTTCGAGCTGAGCCCGGTTGATTTCCCGCACTTTCTCAATTCTTTCCTCTTAAGCCACCGCACTTGAACAGGAGCAGTTCACACATGCAAACTTGGACTTAATCATATTAAGACCCCCCCCCCCCACCCCTCTTAATTTCCTAATCCCCTCCCCCTCCTCCTCATCATGACCAAAAGACAATTGTCTTCAGGCGAACCATCTTCGTGAGAGAACCCTCACACGGCAATCTACCGTCTGTCGAGCACAACGTGCGTTCAAGTGTTGTGTCGACAGTGTCACGAGCTGATGGGCTTCCCGTGGCGAATCGCCAAATCCGCGAGCATCGACACTTTCCTGCTTGCCGCCAAGCCAACGCTTGTGGCGATGTTGTGTAGGCTTGCTGGATTTCGATTCGGTTCTTCTTGCAGCTGGTGAGTTAGTTATTTTTAGGAAGAAATTATATCTGTGTAAGTCCCCCAAATATAAGCCATGTCCCTCTTAATAATGAAGCTTCTGACTTAATTTACTATAGATTTTGAATTTCGTCTATCGAAAAATTAGGTTCACCATGATTTGTCGATTTTCGATGCACTATGATTTGTTGCTAGGATAGAAAACAAGAAAATTCGTGGCCTACGAAAGTTTTTTAATTATTTCTTTTTGTCGGCCAAGATGAAAAAGTCACCTTTTGTGTATGGATGCAGCATGACCCTTTTCAGTGGATTTTGGCCCAAAAATCGTCAAAAGTTTAAAAATCAAACTCTAAATTACCTTTTTTTTTCAAATTTTCTTAACAAATTGGAGCATTTTACAGAAAGCCGATGCACCGTGATTTTAGTTAGAATTGAAAAAACATTCTCGGGCAAGTTGCAAAACTCACATTTAATGTATATTCGATGCACCATGACCATTTTCGAAATTTTGCGGTACCTATTCAAATAGTGCACATAGGCGTACAAACATTGGTGGTGGCCTCGTTTCCTCATGCTTTCGGCCACGAAAAAAAAATATACAGTTTTTGGGATCGGGGAGATGCACCATGATTGTTTTTCAGTGAAAGCCTGTTTTTGCTTAGCAGTCTCAAAGGTATCCGGCTTAATGTTCCCACGCTAAAACGTAATCCAAACATTTAAATTTTAGCGTCAAACTTTTAGGCCCGGCGTACACTAAAAATTGTAAACTTTCAATATATCAAAAATATTCTGACCTATAGCAAAAATTAAACCTAAAAGCAATCAGATATTTTTTCAAAAAAGCTTCTGTGTGATGTCCAATACATGGGTGTGCAGCTAATCTTAAAGTGCTGGCCGTGCTTAACATACTCCGAAAAAGAGTGATATTATTTTATGCTTTTTGGAGCACCAAAACTACTGAAGTTCGTGCTTAGCAAACAAATTCGGCATATTTGCCCCCCTGGTCCACTAGTTAAGCAAAACCCACCGCTGAAAACTAATCAATTGGTGTTTGAAACGGGGAGTGCTAGTACTAGAAGTATTTGGCTGTTCAAAATCTCTTTATTAAACACTTCTTTGTGTCTATTCTGCCCTTTCCTCCTCCCCGCTCAAAATCACTGTACCTCTAATTACGGTCAACTGCGGGTTGAGTTTAGTGAATGAATTGTGAAATGAATGAATGAATGAATGGATAGGTAGATGTGGGTTCTATGTATGTGGAGAAGTGCGACACATGAGCACAACCAGCCGTCACCGCCACTACCACCAGCAGTAGCAATACCCATCAAATATAAGCCTTGCATTTCATTATTTCATAGTGTCATAGATAGTAGCAGGCCCCGAGGTCCGAAAGGCCTAGACCAGGCAGCCGGCAGGTTATATTCAGTTCATTTTTTGACACCCCCCCCCCCCCCCCCCCCACCTCTACAATTCTTCTTCTCTACACATACATTAATCGCATAGTCAGGCCATTCATGTTTTTCACACAATTTTGTTAATAAAGCCGCTCTGGTGGCCGCCACCTCTCAGTAGTCCTTTTCCATCGTCTCTTTTTCCCTCTCCCTTACGAATAAACAAAAACAGTCATTGATGAACGACGTATCGGAATTGTAGTCTCGCAATTATGGTAGGACATATGTCTTGCCACGAGCCGTCCACTTGGCCCAACGAATCACTTGGTGAGTCTCTTTACAGCTTGAAATTTGTGTTGTTTTGTTGGGAAATATAGTTAATCGTTTTTTTAATTAGTATCTCCAATTAGGCCAAAACTACAATCGTGAAAGAATAGTTTCTGCACATGGTGCATCGCCCTGATCTATCTCACTAAACTTTTTTTGGGCTTCATCAAAAACTTGTTAGCTAATATAGTTTAGCATCACTCTATTGATATGTTCAATTTGAACCGAATATGGTGGATCATTTATTGCAACTGAAACAATTTGGCGCATAAAATTGCAACTATGTAGTTTATGTACATCGATCTTGATTACCGTATTTCCTCTATTGTATTGCACCCGACATAACTTTGAAACGTTATATCTCGGTTCATATTGAAGATATCAATAAATACTATTCCGAAATGAAAGCAAAAGAACTAACAAAGATTTTGTTAGTTGACCATTTTTGAATAGGACAAACGATTAAGATGTAACAAAAGTGGACAATGGGGAGCAATACTAATTGTGTAAATACCTTATATCTCGGTTCGCTTTGGTTTTAACAAAAATTTTAAACTGACAAAATATCATCTTAATGACCATATTGTAGTTAACAATATTTTGATATCTTTAAGAACTAGCGATTTTCGACATGGTGCAACCTCAGTCACCTAGTCTAACTTTGCTGGATTTCTTAGTTTTAGTATTAACCGTTCATTTTAATATACTTTTATAAATAGTGTCCTAACAATTTTTTGATACCTTCAAACGTGTTGAACAGGAGCGGGGATTATAGCATGGAGCTTTGATCCTATCTTGCCTTAATTTTCAAGCTTATTGTTGTAAAAAAAATTTAGACATGGTTCATTGACCTGAACTACCTGATATATCGTACTTATCTTCAATTTTAGCAAGTTTTGGAACCAAAAAAATATTAATAAAATCGATTTATAACATTTTTTCCATTTTCAACCTTCCGACAAAAATTTTCAATTTTGACCTTTTTTTATATGGGAACCCGGCAAAAATCTAAAAACTCCCAAGAACATTCTCCCACGAAAACCTAAATACTTGTAAATCTAGATCAGTCAACATGATTTGCACCTTCTTCCCATGGGATGGCTAAAGAACCCAGTGCGATGATGAATCGGCCTGTGGGCCGCGAGCAGACGCCGCTCTAATCACTTTTGGAGCATTTGTATATATATAGCGAAGAATTTACGTTGGGACCAATGAAACCAATAGAAATCCAAACATATTTTTGTTTTGTAATCTCTTCCCTCGCTGCTATCAGCTCTCTTGCCCCTCCTTAACCAATCAGAGACGCAGGCACACACCGCACCGCCAGTCCGTCATCGTCATCGAGTTCCGCAATTAGTCGTCTATTCTATCCGTTTTTGATTGGAGTTATGGAGCGGAAAGAGAAAGACCGAGAGAGAGAGAGAGAGATTAGCTCTTAGATTCATTCAACTAATCTTGAAATAACACACCCACACACATACAAAATGAATAAGGTATCTTGATTTCTAGAAAATCATGGAAATCAGCAAATTCGCTAGAAATGGAAGGGGAAGCTTGAAATAAGAGCACTACTTGATACCGAGTTGGGTAGTGTTTTAATATTTGAAGAAATATTACAATTTTGCATTCTTTATACTTCTAAAAACAAGTTGCTTGATGCATCATGCCTCTTTAGATAACGTTGTCGTTGTTTTAGGCTTAGGCTTAGGTTTAGGCTTAGACTTAAGCTAGGCATAGGCATAGAGGCTTAGGCTTAGCATAGGCTTAGACTTAGGCTTAAGCTTATTCTTGGGCTTAGGCTTTAGCTTAGGCTTAAGCTTAGGCTTCGGCTTGGGCTTAGGCTTTAGGCTTAGGCTTAAGTTTAGGATATAGGCTTAGGCTTAGGCTTAGACTTCTAGATTTCTCGTAAACCACCAAATTACTGTATATTCTCTATCATAGATACTACTTCGGACCAGCTTATAACTCAAGTCTTTTATCAGAGATGAATCACTGCTTTAATTACAACAGGTTAATAAATACACCATATTTTATTAGTTTAAATTTTTTGATTAAGCTAACGAGAAAAATATGACTAGTCAAAGATTATCGATGCACCATGGTACTACACTTTACTTTGCCGGCTCATAACTCGGTTTATTTTCAGGATATCAAAAAGGTTTGATACAAACCTATTAAGAGAAACATATAATAAAAATATTACTATTTTGTAAGACAATTTTGGTAAAACTAATAAGAATCGAGGTAGATATAGGCCGTTGAAGTAGCATGATGCAGTTGAAAGCCTACGTTTTTAGACTTAAAGCTTGAAAAGGATGTACCGTCACGTATTTCCTCTATTATTGTGCCACCCATTGTTCAACTGTGAAATCTTTTATCTCAGTGACTGTTTGTTCTAATCAGAAATAGTTAACAAAATATTTCTTAGTTCTTTTTCTATCATTTCTTAGTTGACCTTATATTGATACTAAAATAAACCGAGATAAAACGTTTCAAAGTTAAGTAGTCGGGTACAATAATGGACGAAATCATGCGGTATTAAATATTTTGACACGGTTAACTATTTGAGCTAGATTCTCGATATCATTTTAATTTCTGATCCATGGCTCGTTCAATTGTCTTGCCTAGAAAATCTCTAAAAATAACGTCTACGAGAGCGGGTGAAACAATAGGTGGTTAGATGTAAGTTGATGCCCCTGAAGGCATCCGGGATCCCGGTGTCCGCAAAAACAGTACAAATGTAACATGAGATGTACATCCCCCATTTGTGGTCGCTCTAGTCCAAGTTGAAATCGTAAGCATGCAAAGACATTGTTAATATAGCCGTGACGCGACGGTGGGCTCGCTCGATGAATCAAGATCGTTTTGGGAAGAGAGGGACTGAAAATATTAAAAAAAGATTTGCATACCCTCTGTAATTGTTTGAATCATCAGCATCATCATCATCATCAATCATAACATAGAGGAAACTTTTCCTGCTGTGAATGTGTCTCCTTTTTAGTACAGTCAATAAATGTGTCACTTTAAAGGGGGAGAAGCTTTTCACGGATGCTTTGCTCTCGACCTCCTTCCCTCCTCGCTTATAAATTTCCATTTTTCTCTTTAGGCTCAAACATTGATTGATTTACTTATTCTATTGACATTCTGATATTAATTTGATCATCTACTAAAAGGTATATATATATATAACGTATATCAACTCTTGGAGCCCATATCTTTAATGCTCATTAAACTCTGCTCCCAGTTAGGACTCGTCCGGGAGTGTAGTACTGGGTGTGGGATAAGAAAGTTAGGATGTGACGGGTTTCATGTTCATCTCGAGCTGCCAATCTTGCACATTAAGCGATTGGCTCATTGGCACTCTGTTTGTCCTCAGGGCCTGCCGCGGAGCCATCTCCCGTTTGATATCTGCTCCCGGACGTTCCCATGGCCGGAGAGAGGCGCCGCGAAGCACAAGCTCAACCTTTTCTAATGTAATGGGCCGGTGTACAATTAGGGGAAGAAAACAAAGAGGATGAGAGGTTGGGGTGGATGAGGCAGGGAAAAGAGCACCACCACCAACTGATTTGCTGGTTGGAGAGGAGCTCGTTCTGTTTTCTTGTCGTCGTAAAGTAGGAAGAAGAAGAGAATCGCGCTAGTTAGTGGTTAAAAGAATCGAGACCCGAATGTGATAGATGTGTCGCCAATTTAGCCAGTAGGATTTTTGCTGATTTTGCACACTTCTTGCTCTAGACATTACATCCCATCTTACGCTTCATTCATTGTGGTGATTTTAAGATTTGGGGGACCTAGTTCGAGCCTCTACAGTATTACTTTAAATTTCACTATTGTTTGGTTTGAAAAGAGACTATTGCGTCATATCATTTTAAGGCACCTATGTATACAGTTCAAAATTTTGCAACATTCCTGGACCATAGCGATCTTAAAGCGGGAAATATAATCCAGACATTATCTGATAACCCATTTTTTCGAACTCAAAAAATTGAGTAAAGCCAATTGAATCGTATCCCAAGCCTAATGGATTGCAAAGTTGGGCCATTCTGAATAGCTTCGAGTTCCAAATAATCACTGAAGCTAGCCAGAAGCTGAACGCACTGACCTTCCTGCCAAGCCTTTCTTTAGTGTGAATAAGTCTCAGACTAGAAGCACTACCTGATGAGAGAGATTCCTTTCTCTCATAAGTAGTCTATTTCATGATGCAAGAACTTACAGCATTTACATTACCATGTAACATTACTTAAGATCCCATTTCCACTTAAAATGTGGGAAAATCGATACGGTTTTATAAGAAGTGTCTTTTCGCATCTTTATAGCCTAGAGCAAAAAGCCAAATTGTTTGGCAGATCATGTCTCCGACAATATTCTGATCGATTAAGAAACTTTTCCAAATCTGCTCGGTTTTTTAGTCTACGCGCCCAGATAACTGTGTTCTCGGCATGGCCGATTTGCCGATTTGCCGGAAAGGATTTTTACGTACTTTACGACAACTTACTGGCATTTGCCGGAGATTAAGGGAGAATTTTTTTGAGACGGAAAATTTTTTCATTAGAGATGTTCATAGAATTAGCTTACACTTACAAAATAGGTCTATGAACATATTCAAAGACCGATGCGCAACTTTGCCGATTGAAATTGAAATTCTGAAATTTCCAAAAAATAAATAGGTGACACAATTTGCCGTTTTCCGGCCAATTCGGCAAATCGGCAATTTTCTGGATCTGCAAATTTGCCTGAAATTTTCAATTCCCTTTATTTGCCGGGTTGCAAATTTGCCAGAAATTTTCAATTCCGCACATTTGCTTCCGGCCAATTCGTAAAATCGGCAACTTTCCGGGTTCCAAATTTGCCGGAAATTTTTCAATTCCCTTTATTATGCCGGGTCTCTGCAAATTGGCCAGAAATTAATTCAATCGGCAATTTGTCAGTTAACGTGTAAATTTTCAATTCCGGCAATTTGTCGATTTACCGGAAAAAATCGTTTGCATCAACCCATGTGAACGCTAGCACACCTCCTAGTATTAAGGCTCCAGCTAATTTCTGACGCATATCATGGTTCCCAACTATACGTTCCTCCCCTCCCCCTTCCCACACCATTTCGAATGGGCGCCAATTATTAATGGATTCTCAATTCCCATCATATTGGGGGGGGGGGGGGGGGGGGCATTCGTACAGTCTCAATACGAATAATACTTATAAGCCCTCTTCTATGCCCAAAGCGCGGCCTTCTTCTTCACCCCTCTAGGCGATAAATTCTCATATTTAGCATTTTGTAAGACTCGGTCTCCCCCTTTCAAGTATCTCTGGGCGATGATTCCCGCTCTAGCTCTCGCACACACCCCATTTTTTTTTCACAATAATCATTCAAGGTGGACACCAAAAAAGCCATCAGTTCGATTCCGGTCAAATCGAGAGAACTGGAAGAGAGAGAGAGAGAGAGAGAGTAAGAGGAAATGAGACAGAGGGGTGAGAGATGGAAAACGAACAAGTTTGATGGGCGTCCCCCCCCCCCCCCCCCAGGGCCGCTCCTCATACTTAAATTTAACAGCTGTCACTCTCTTTTGCTCTTCAATTTCTAGCTCTCTAAACTCCTCAGGTCTACAGTAATCGGGGAGGGGGTAGTGATAAGCCTCTTCCCGCCCCCCCCCCCCCGGGGGTTAGGTGTCAGAAATTAATCATAGATGCCACGCCTCTAATGTTTTCGGAAGCAGTCATCCTCGCTTTAAATCTTTAATTCATTAACCTATTAATTCATTAGTCTTACACTGTCAATTTCATAACTAATGTTGAAAAAACTTCTCAAAAAAAAAAGTTTTGGCGGCTTAAGAAATGGCCTAATATTAGTTCGACTTTTCAAGCGGCTGGAAACTAACTTTTTTTGAGATCCACCCTAATTTCAACAACGTAAATAAAAAAATTTGGTGACCCAATTAAATTTATTTAGGCCAAATCTGGTGTTCAAATTTTTTAGGCCAAATCTGGTGACTAAATTTTTTAGGGCCCAATATGGTGACAAAATTTTTTAAGGCCAAATCTGGTAACCACAATTTTTTAAGGCCAAACGTTTTTAAATACCAAATTTAGATGTTAGAGCCAAAGTGACGGTGCAAAGGTATTTAGGGGCGAATCTAATGACCACATTTTTTGGCCAGACCTGTCCCTAATTTTTTACAGGGCCAAATCTGGAGACCAAATTTTTTAGGCCAAGTCTTGGGATCATCATTTTTTAGGCCAAATCTGATGACCAAAATTTTTAGGCCAAATCTAAGGACCAAGAAAATTTAGGATTTAGGGGCCAAATCTGGTGACCAAATGTTAGGGCCTCTGGTGACCAAAATTTTGGCAAAATCTAGTTACCAAATTTTTTAACCAAATCTGGTCACCGAATTTGGCCAAGCCTTGTGATCAAATTTTTTTAAATTTTCAAATCTGGTGACCAATGTTTTTTGAGGGCTTTGGTGGCAGCATAAAATTTTTAAGGCCAAACTTTTAGGACAAATCTGGTGACCAAATTTATAAGGCCATAATAACTTTTTTTTGAAAGTTTGAAGACGTTTCTAATTCATAAGTCTTTATCTTTTTCAATTTAATCTTCGATATTCTAGATTTCAAAACGATGGAGGATGCGGCTTACGCGTGTGCTGGCTGCGACTTCAAAGTGAGTGTTTTTTGTTGTTTCCTCATCAGCATCAGCTCTATCTTCTCCCCACCCCACACCGCTCATGGCCACTTCCTGTAACCTCCAATTGCCATTCATTTCACACAGTATTAGTACCACACAACACCCTTCCATGCAATTTGACTCATTCATAGCCCTTTTCTGGACCATGTCTTTCTTCCCCCTTCTTTCTCTCTAATACTCAACCTATACCTACCTACCCGCAATTTAATTGTTGAGCAACTAATTGATACACTCGGACGGCTCAAACGATGCGCGTCCGTCGTCGAGTGCCCAAGACTGGGACCGGTTTTCAGAATGTCCAGTGTATGTGTGTTTGTGTCTACGGCTGGCAGGCAGCCACACCACTCCGATTCGTTAATTTATTGTGAGATGATGACTGTACATTACTTTAAGTGCTGCTGGTGCTGGTGGTTTGCATCATATAATTATAGCTGATTATATTGACACACACACACATACACATTTACTTTCAATTGCTTTTACCCAATCGTTTTTCTTCCATTCCCCAATCTCCTTGCTCCCATTTGGCCCTTTGATATTAACCGCGTTGCGCGTTTCGCACTAATTTCGCGCCCGGACCGGTGTGCTCGGCGCGGCACGTCTTTCATCTTTTTACCTCAATTTCATTATGATTATAATAATCATATTATGGAAGCGAGACACGGCAAAGACGCGCTCAAGAAACTGATAAATGTGTAGAGGTCGGGTCCTTTTGAGAGAGACGGAGAGAGCGAGGTGTGATAAGAGCGCCTAATGAGCATGGGCAATCATCACATTACTATCAGCAGCATTAAAACTTTTTCAGAAGACGTGTCGGACTTCATTTGAAGAGCACACAAAAGGACACGAAGAGGAGGAACGGGAGCCTCTTCACAGAAGGCGTGTGCGCTGTGCCTGCTGAGCCCACCGACCACCTCGAAAAGCACCTTGTCGAGCACCCTGCTATCGCATCGCCGAGAGGGCTATCGAAAAGTTCCTGCTTACTGAGCGAACAGCCAAGTGAGTGTTTTTTTTTCACTCAAATATTTAGTAGTAAATCTTATACTTTTATTTCTAGCGGTTTCATTTTTGATAGCTAGTTAAAAACCATAGAATAACAATTAACTTTTTGACACCTGTCGTTTGAATTTTTTGACAAAAATTTTGTCGTTTGAATTTTTAAAATATGATCGAGACAACCGAGATATAAAAGGTCAAAGTCCAGTGAGAGGGGCCATAATGATAGGGATTATACGGTAGGTATCGAAAGAGACTTATAAGGACAAAGATAATGGCGCTAGAAAGTTTAAACTAGTCCAATTTGAACAATAAAAATATATATCACGTACTTCCCATTTAGTATAAATATTTTAATGAGAGTAATCTGAGATACAGTAAATTTTTGATTAACAATTTCTAGGCACCATGTACAAAACCTAGTCCCCAGCCCTAAAATTAAATAGCACGTACTTTTTAGTATAGAGCCTATTTCAAAAGTTAAGCCATCTGATACACAGTGAATTCTACCAAGTCCTAGTCGATGCACCATGTGCCCACTTGACTTTCACGGCGCACTTCCCGGCTAATTTCATACCTTTCAGAATCGCGATTTTCAACTATTAAACTATAGAGGGGTTTTTAATAAACATTTTCTCTGTTGACGACTTTTTTAACGTAGAATCAAAGACTACCTCGATAGCTTGATAGTTAAAGTCGAGATGCAAGGTTTTTTCGGAAAAATCACGCGGTGTTTTCGGTTTGTCTACGTACAACGAAAAATTCGGGAGAAGAGACGCAGAGGTTATCAACTCGTATGGTAAAGAACGTGCTGACGTTGTCACATATTTTTGAACAAAAAATCATTTTTAGATCAAACCGTAATGGGGCAACCTCGCACCACGTGAAAAATTAGTTTTTGAGGCTTCTCTAGTCTAGAGACTCACTAAAGTATTTTTTTTGATTGGCCTTGTTTTTTCTAGACTTAAAGACCAGTTAGATCCAATCAAGGTTTTTCAGAGTGTCGATTTTTATGAATTTAAAACTTTCAAATTGTAATCGCACGTTCCTCCATTTCAACCCCAAACACGTTACGATATTGTGCTATCATAATCATTCAACCATGCTTGCTTGTGTGCAAGTTGCACAGGGTGCGCCGGTGGTGGAATTGGCATTACTGTAAATGTCCTGCGTCTCCATCCTTGCCCCCAGTGTCCCCATCGGCATAACTATTCGAGAGGACGATCCGCTTTTGCATATCTAATTGTTCAGGATTGTTTACGCGCTCTAAAATTCAATCCGTCGCCAACCACCCGCCCCCCTGCCTGACTCTTCAATTCATCATGAGTATTAGTGTATTGATTAATTTTCGAATTCACGAATCAGTGCTGGCGCCCTGCTACTAGTAACCAGTGAGGTCATAGCGTTGCCCGCAGTTTCGATAGGGCTAATGAAATATGTAGTTTCTCTAGGGGCGGGAGGATAGGTTTGATCAGGAATTGGGCGTCGGTTTGATCTACGTAGATCTATGAAGATCGCGGGAATTTAGACGCAGACTTCTCAACTGATTTTGCATGGTTAAAAACGTGCTGACGTCATATGTTTTAGGGGAAAATATTGCCCGCACTTTTTGTAGATCAAACCGTAATGGGACAGCCTGACACCATGTGCTCAGTTATGGTCCAACTAGAGGGTTTTGTCGGAAAAATCTGCAATCAATTTTTTAAACTGACAACACATTTAGCTCCTTCTCCAAAACTGAGCCAAATGTGTAATGTCAAACTTTTCTTGAAATTTTTGTATCGAAATTAATTGATGTTGAGGTGAATTTTCAAATTTCAAAAAAGGTACTCATTTCTATCAATTTGTCTTCACCTATGTTTTCGACTAAGTGCGAGGCTAGAGGTGGAGGTCCCCTTAAAATCATAAGATAGCCTTATGTGATGTCGAAAAATGCCAAAAACCGCAATGTATTTTTCTATAGTTTCCCCGTGTGTAGAAGAATGTAAAAAGAGCATGCATTTTGTGATCATTTTTTGACATTTTCCTGCATTTTTTTTTGACAATTTTTTTTCATTTTTCCACACAGATGAATAGCGGAAAAACTTAGGAAAAAAATACCATATTTGCATTTTTCATGATCACATGATCCCCCATAAGGTTTTTTAAGGCATAATATTGATATTTATTAGTCTACTTCGGATGCATAATGCCTACTATTGAAGGCAAATCAAATCGACATCACTTTTTGCTCATTTTCAAAACTGAGAGGCACGGCTTCTATGTTGACTACTAAACCAGTCAATAACACTTATAAAATGTTTGGAAAACACTCATACACAGCCACGTCATAGCTTGGACTGGATGGGACCCCATTTCTTGAATCATAAAACCTTGATTGTTAAACTATCATCCCCCCCGCCCTCCTCATTGGACGACCCCACGGCTCTGTCTCCAATTTGTTCCCCGTCCTCTTCTTATCACCTTGACGCGTTGCTAATTGAAATTTTGCGTAGAGGATTTCACTTCCTCCCCACCGCTTCCTTTACTCCTTGGGGGATAAGTATGGAGAGTGTTTATTTGTGTGATTGAAGTGAAGAAGGTGGCTGCCTCATTATTTCATTTTCGTCGCTTTCTTTGAAAGAACAACTTGACAGTTTCCCCCCCCACCCCCCATCTTAATAATAATTACTTGCAGACAAGCGTCGTGTTCACCGTAGTCGGAGTCGAGCTAAGAATTCGCGCATCGCTGCTCGAGTTGCTCGATGGCGTTCCGAAGCGAGTCGCAGCTGCAGACGCATTCCCTTCAGCTCGTGTTCAACTCGTTCCACAAGTGCCCCACGTGTGGCGATTCGTTTGATGACAATACTATTGGTGAGTGTATTGACACACTTTTGGGTCACAGTCACGCTTGATCTACGTGTTTTTAGACACTTTTGAGTCTACACGTCGTGTCAAATGTCTCTTGGGCTAACTTGATCTGCGTTGATATACCGAAAAATGCGGGAGGTTTTGGGCAAAAAATTCCCGCATTTTTTGTAGATCAAACCGTATTGGGACAGCCTGGCATCACGTGGAGAACTCAGTTAAAGTAAGAGGGTTTTGTCACTAGATTTATTTTCTGTAAACTGACAACACATTTAGCCGCACTCATTCTCCAAATCTGAGCTAGGTTGTCGACCGACTTTTTTTGAAATTTTTTTAAACGAAAGTAGTTTTGCTAGTTTTCCTAAAAGGAGAAAGAAGGGTTGTCCAATTTTTATAAGAAGGTTTTTGTCGACTCGGAAAAACGATTTTTGTAAATGACAACCCTTTTCGCTCGTCTTTTCAAAATTAATTTTTTTCTCTTGGCACTTAATCCCATTTTATGTAAATTAACAAAAAAATGTCAAAAAATCTTCAAGTAGTTCTACAGGGTGGCCTATCTATAGGGTGGCCTACATTTTTGCACGGGTTGTCTAGATCCTTAAACAGGGATGGCCTCTCTGTAGTGGCCTAGACCTTTTCTACACGGTGTAGATTTTCACTGGTGGCCTAGATTCTCACACTAGGTGGCCTAGATTTTTCCACTAATCATAGCGTAGATTCTTTACAGGGTGTCCTAGATATTCACGGTGTCCTACATTCTACACAATTGTGGGTGACCTAGATTTGTTACACTGGTGGCCTAGATTCTCTACAGGGTGCCCTAAATTCCTTATAGGATGACCTAGATTCTTAAACAGGATGGCGCTACCTAGATGTTGACACTAGGCCTTGATATTTTACAGGGTGGCTACCTAGAATTTCTACAATGGCCTAGATTTTTTGCAGGGTGATGCTTGGATTATTAAACAAGGTGGCCTAGATTCAGGGTGGCCTAGATTTTATACAGGGTGGTCTAGATTGAACGTTTACACTGGTGGGCTAGATTCTTTACAGGTTCGCCTCAAGATTTTCTATCGGATGGCCTAGATTATTAAACACGGTGGCCTAGATTGGCCCTTTACAGGGTAGCCTAGATTCTTCACCCAAAGCGTAGACTAGATTTTTCTGGTGGCCTAGACTAAAGGGTGGTGGAACTAGATTTTTGCACTGGTGTATGGCGTGGATTCTTAAACAGGCTGGCAAATTGTTCCCCTTAGGGGATGCCACTAAATTCTTAAACAACCTAGATTTTATACGGGAAGGCCTAGAACTACTTTTTGTAAATGACGGCACTTTTTGCTCGTTTTCCAAATCGTTTTTTTTTCAGAGCCATATGTTGGAGCGTACACCAAAGAAGAATGCGAAATGTCTGAAACATTTGCCACAAAAGAGGCATTCCCCTCCCCCCTGAACTCAGCGTCACCTACTGAACACAAAGAAGCATCTGGAAAGCTGGACTCGACTTAAACTCTCAGGTGAGCCGCCGCCGCGCCTCAGGCTGCCGCCTGGCTACCGTAGTCACCGTACCTTTAATTGCTATTATAGCCACGCCGCTCAGCTACAAGCTCGGAGCGCAGAGGTGACAGAAAAAGCCGACAAAACATTAATATTATTACACTTTTTTATGATTGAATGCGAGAGAGATGTATGTGTGTGGAGTGGAGAGGCGCATGAAATGGTGTTCGGGTTCCATAGCAAGCTCATTGAGCACAATGATTTGTTTTTTAAATATATTTTATTGGAAATGACAGAAGGTGAATCTTAAAAGGAACGTCCAGTATTTAACTTAAAGTATTGATTTAGCACGTAGTTTCAGCCTGTCCCATCACGGTTTGATCGTACAAAAAATGCGGGAATTTTCTTCCCAAAAAGTTTGACGTCAGAGTTCTTAACCATGCGAAATAAATTGAGAACTCTGCGTCTCAACTCCCGCATTTTTTCTAGATCTACGCTTAGATCAAACCGATATGGGGCACGTTGCATTTGATATTTAAAGGGTCTCGACAATAAAGAACTCAAAATAGCCTTGCCAAGATAAATGGGCGGAGCTTTGGTAGGAATTTTCATAAGTCGAGGACTCCGCCCAGTTCGTTGGCCAATTTGGGTTTTTGTTCGTGCCTTCAATTTTTAGTGTTTCATTAATTTCCAATAAGTTTAAGATTGAAATAGTTTTTGAGGTGAAAACTGATCCTAGCATGGGCCGCCCATTTGTTGGTTTTTTTTTTGTTTTTTGTTCTTTTAAACTAAAATTCCACTGAACTTGTCTAATATCAGTTTCCATTAACGAAAAAATTCGAAATGCCATGAAAGGGGAGGAGCCTAAGCGAAGACTTTTTCGATGAAATTTGGCCAAGTTGCGATGTTTTTGAATTTCATATTTTTGAATCAAGTTTTGAAATAAAAAGTAATATAAAATTGGAAAATAGGCTCCGCCCATTTATTGGTTTTGTTGGGGTATTTTTTTCTGCATGGATCATTTTTGCATCCGAAAATTTGTCGGAAAGGCATTTTTCCCAATTTTTTTCCGTAAACTATCATCAACTTTTGAGATTCAAAATATCCAACATAAGCACGGGGTTCTGGCCTTCCTCATTGAATTTTTCGCGATCCATTGACAATCATTTGCCTGCCGGACAACGCGTGGGAAAGTCGTGTACTCCACGCGGACAATTAGAGCCATTTTAAGCGCCGCAAATCCCAGATATGGCCGAGCGAAAATGGCCTAGTTCGGCAAACTCTTTCTGACGATTTCCAGAATTTATTAGGGAAGACTCCGTACATAGGCTCAATAAAAGGTGAAATAGGCTCCGCCCATATCTTGGATCGATTCCAATATTGAAATTGACATGTGTTAGTTACACTTGTTCCTAATCCAAAATTCTATCCGAATTTCAATTACCCAAAGTCAAAAAGTCAACAAGTTCTGTTCTTATATGTGCGCGCGCGAGCGCGATCGTTTGTCTCTAATATTTGCTCATCTCTCTCTCTCTCAATCACCGCCATACCCAAAGGATTATCGCCCATGGATGATGGGATGATGTTGAAGACTGCGCGGTGGGCCCCCTATCCCCTGCCTCGGCATTCATCATGTTTGTAAACAAAAGGCGGCGGTTTGAGAAAAGAAGACAGTGAGCGGGCGGGAGAGAGTGAGGTGATGAAGGTAGTAATCGTGTGTCGACGAAAACACATATAGAGAACAACAGATTCGTGTGAAATAGATGAGGGCAAATAGGACGAATTTATTTAAGAGCAGATTATGATGCTTTGGCCCAGATGAGGGGGGGGGGGGGTATCATGAAGATGTGATGACGAACCATATCGTTCCTTCAATGTTTGTTGCTCGCTTAACCGCCGTCGCCGCAATTTAAAGGTTATTTCGACTGGGTATGATCAGATAAGAAGACGTAGACGGCTTTTCTTGGGGGGGACGTTCAGCTTTGATTCCTTTCAAATAATCAATGCGGCCTAGCTTTCTGATCTACAGGCGGGCCTTCTTTGCTAAATTTTAAGCGATTTTACTACCTCTTTGGCCCGCCCCACTTTGATCTACTTTAACTAAGCTTATATCCGATCTCGGTTGTCTTTAGCTTCATCAAAAAGTTATGAACTAACAAAGTGCGTGCCAATACATACTTCTACAATTCGGTAGTTAGTATTGCGATTTTGGATTAAAGTTAAGACAACCGAGAGGCTGTAAGCTGTTGAAGTAAATTTCTAGTTTGACTTACTCCCGACTCCAATTTTGATCTACTTTTACAGCTTATATCTCGTTTGTTTCTGGTAACAGCAAAAAGTTGCCAACTAACAAATTACGTGCCAAATATTTTTCTAAAATTTTGTAGTTGAAAATTTTTGAATAAAAGTTAAGACAATCACCGAAAGCTGTTGAAGTAGATTTCTAACAGGTTTGACTTACTCCCCAAACTTCGATCTACTTCATTTGACAGCTTTTATCTCGGATATTATTTTGGCAATATTAAAAATTTGTCAACTAACAAATACGACCCAAATATTTATCTACAATTTGGGAGTTGAACATTTATGTTAAAAGTTAATACGGCCGAGAAGCTGTTGAAGTAAAGGTGGTGCTTAGCCGACCTATATTTTTGAATTACACAACAGTTATAACTAACTTATTTTATGGGTAACACTATTCTAGCTAGTTGACTTTCAAAATCTACAGAAACTTTTGTTCCTGCCTCCACCTTTAGCAGCATAGCAAAGCGCCTATAGGAACACCTACGGCCTACACCTCATACCACCTACTCGAGTACACCTACTGCCCATCTACTGTTTGCGTACTTTCTACATAGCTTTGATGCCCGTTCCTAACCAATACTCTTTTACAGGACAAAAAGCGGCGTTGTGTGCAACGTCTGCAAACCAAATCCTCCTATCTTCCACATTGACAAGCGGCAAATCTCTGACAAGTGCACATGAGGTCAATGACACATCAGACCCGGATGAGCCGGCTGTCCGAACTTGTGGCAACCGGGGAGCTTAATGGGGAGACATGCCGTGTGTCAGTAACCAGGAATCCCCGACGATAAACAGCATCACTGAGACGGTAGGTGAGGGGTTTGTGCAGGCATCCTGAAAATCAGCTGTTTGGTTTCTGTGAAACATTTGTGCGGAACATAGTTTATTTATAGTTCAATTTGAAAAAAACTGGTTTCTGAGAGTGTTCAATCAATTTTCAATGTTCGATTCTCGATTAATAAAATTTCCACTTTCCAATTCCAGACAACCAACATCCTCTCTGAACGACCTGATGTCACTGCTCACACGAAGCGGGTCGGATGAGATTCGAGGTAAACGGCCTTCAAGTCATGACACAGATCAAAGTACGGTGACCAAGATCACTAGCCTAGTCCCAGAGTTGGGAAAATCGATAACATTGCGCTCTTCGATGACTCCGTGCGGCAGAGGTGTCGAAGATCGTTCTCGGCTTGTGGGCAGCAGATCTCAGGGATCCTTGCTTTGAACCTCCATTATGAAGAGTCCCATCGAAGATTCCGAGTGACGTGTTAAGAAAGTTCGGAGACGGCCGTTACTTGCCGCATTAGAGGAAGCACGGGTTAGCAGAGAGTTCCTTGAAGAAGGATCGCAAAGCCCTCTGCGCAATGACGATGAGCCCATGGAGAAGAATATGCGGCTGGAGAAGACACTCTGCTGCCTGAAATGGACAAGAACGGGGCAGCGTCGCAATTTCGCATAATGTTCCAGACAAATGATGAACTGCCTCCCGTACACTCATGGCACCAGGCACGTCTAGTGGCAACTTTGGATTCTCGCCAGATAAATGATCAATCAGCACATGAAGCATGCGGCGGCGGCGGCGGCGTCGCGACTGCAGCAGCAACAGCCCACACTGCCAACAACTGCGAAGAGAGCAAGAATACGCACTGATGATCAGCTCAAAGATTACGGTAAGTCGTCTTGTGTGTGATTACTGTAAGCTACGGCGAACAGGACAGACACGAGGGGGGCGGTGGAACATGAATTGCAAACAATAGGTGGGAAATGGTCGGCGCCGTGATCAAAATGAATGAGAAATGAGAATGAAGAACAAACATTGTGTGTGAGTGGTGTGTGTGAGACGAGACGATAATCAATCAATTTCTGGAAAACTACACATATATTTTCCCGGCGAACTTTCTGTTTGAGGGACCGTGCGGAACAAGACCCCCCTGAAAAAAAAAATCCGGAAAATCCTTAGCCTAAATAGCGAACGCTCGCTACTGACGCTCAAGCCTAAGCCTAAGCCTAAGCTACCTAAGCCTAAGCCCAGCCCAAGCCTAAACGGGAACCCCCTGAAAAATCAAAAGGAAGAGAATCCCAAGCCTAACGTCCAACGCGCCACTGACGCCAAGCCGTATGTCTAAGCCTAAGCATCTGCCTAAGCCCATCCCAAACCTAAACAGGAACCCCCTGAAAAATCAAAAAAGACTATCCGGAAAATCTTAAGTCTAAATAGCGAACGCTCGCCACTGACAACCGCCAAGCCTAAGCCTAATAAAGTAAGCCTTAGCCTAAGCCCACCCAAACCTAAGCCCAAGCCTAAGCCTTTCACCTTCCTAATTGTCAGGCAGGCTCTAAAAACCGCGCCTGCCTACAATCGAAGCCCTAATCTGTCCGCTTTAGCAAAATACCCTCAAGTTGGTCGGTGCAAAGGGCACATCAGTATAGTAAACGCGCTCTACTGATTATTCGAGTTTAGCCAGGTTTGGGCGCGTTTCAAGGAAAAGAACTTTGGCTCAAAAATTGTGAATTTATTTTCGAACATTTTTATATGCATCACAAAAATGTTAGTCCACCCGTTTTTGAGAAACTAACGCCCAAACGTCCAGGTATACGGTACATGCGCAAATTGCGTACAGATACCACTGGGGGGTCGTGTTTGGGCTTTAGTGTAGCTAAGGCTGTAGCGGCCCTACGGCCTAACTGCAAGCCTCAGCTTATTCGCCATAGGCTTGTCTGCCGTATTTCAAGCCGACAACAAAAAACCTTTCAGCCAATACTTCAACATCAACAACTCGCCGTCAGAAGCGATCAAGTTCGAGATGTCACAAAAAGCGAGCCTTCCGGACAAAGGCATCAAACACTGGTTCCGCAACACACATAGCTTTTCAAGGGCTTTGTTAATTTATTTTACTTCGAATATTGTTATTAGGCTCGGAGTGGAAATGAGCGAGGTGTGAACATTGGTAATTAGCCGGTTCATCTGATGAATACCCACACGAGAGGGAGAGCAAACAAGGAGAGCAATTGAGACGAGGGAGGGAGAGAGAGAAAAAATAAGAAAATCTTAATGTTAGTTGGGTGCCACGCGCTCGGCCAGGACCACCGGCCGGGAACCATTTAGTTTTGATTATGATTTCCGTCGTGGCTCATGATTTATGGGAATTGACTATTTGTGCTTGTTAGGTGATAGAATAGTTAGAGCAACTATCAGGAAGCGGACAAGTCGCAGTGCGAGACTATTAGAACACGTTCTGCAAGGTTTATTCTGATAGATTTGGATAAGTACTAATATTGGTAGAGACTAAATCGCTCTCTTGATATATACCAGCTTAATAATTGTTCTACCAAAAAAACTGTTAAAGAACGCTTCGAGATTCGAGCTTCGGGAAAGCTTAAAGGATGGGTACCGAAAAATTCTTTTTGCCTGATTCCGAATATGGATGTGGAAAAATTCAAAAAAAATTCCCTGATTTTATATTTGAGCTTTTACGATTTTCAAACCTTTTGTGCCCACCTGGTGATATTTTGGATTGATCTACGAGCTCTTGATCTACAAAAAATGCGGGAGAAGGCAGAGTACTCGACTGACTTTGGCACGGTTAAGAACGTGCTGACGTAAGCCACACTTTTTTGCGCAAAAGCAAAAAATTCCCGCATTTTTTGTAGATCAGACTGTCATGAGACAGCCAGGCACCATGTGTGTGCCTCGGTTCAATTTTCAATTTTTTAAACCAGTTTCTTTTTTTTTAGTCGATACGTTTTCTGAAAGCTAAATATTTTTTTTGCCAAAAATGAATGTAACTGGCTTAAAAAAACTAAATAAAACGATGCAAGCGCAAATGCGAATTTATTTGGGCGAATTTGAAAAAAGTGATGCGGGAATGAAATCGGAGATTCTAAGCAGGCTCTAAATAAACAGGAAAATTTTTTTGAATTTTTTCACATTGATATTCGTAATCGGAGAAAATCCATTTAAAAATATTTTCCAGATTTCGGTGCCCCACCCTTAATGAGATAAAAGAGGAAAAAAGGAGTTTTGTAACCTTTTAAGTTTTTTCTTTTTCAGGAACGCCAAAGCGACAAGGATTCCCCGTCCAACTTCAGCGTCCCTCCCCAAATGGGAATCGACTTGGTCTACGAAAAGACCGGAAGTACTGTCGCTTATGAAGCACCAAAGTCTGAGTTGAGCTCTGCGCGGGCCACACCGACATAATTCCGACTCCGATACCGCTCATGGATCGTTGAAGAGAAGAATCCGGTGCCAAACCGGACACCATCGTCTTCTTCCTCTCAGCTTGCAGGCTATGTTATCTCAGATGCAGGGAAGTTTTTTCGACGCGTCAAACTTCATGTCAGCATCAGTGAATCCGATGACAGCACTCCTTCCTACCGTCCAGTGGACGACAAGCCCGAATGGCTCTAGAATCAAGACCGATTTCCAGCTGAGATCTCTACAGCAATTTTTCGACAAGCACTACCCGAATGATGATGATCTAGAAGCGCTGACCAAGAAGCTTCAGCTGACCACGTGTGATTGTCGTCGGGTTCCAGAATGCAGAAGGCCAGAAAGATCTATGAGAATCAGCCAAATCACGAGAGTTCCGATCGATTTGTGAGAACGCCGGCATCGAACTTTGCAAAAAAGGTTTTAGTGTTGGAAATTAAAATTTAAATTTAAATTTTCCTAAATTCCAGGTGCTGCCAAGTATTCCAACGCTACTATTCGTAGAACTCATCCAACATCAAAAGAAAAAGTGCTGACGATGTAGCAGCACCTCTGGCAAGTGACAACCTCAAGAGTGTCGAAGAATCACTGACGGAAGAAGAGAAATCCCAGCTTCTAACAACAAGTAGCCCAACTAAGGAGTCAGGAGCTCCCAAAGTTCCAGCCGGCAGAGCTTTTGAAAATGATCGGAGCTAATTCGGTGACTCCATCCCGGCTGCAAGTCAGAAGTCTAGCAACGATGCCGTTCTGCTGAAGATGTGTGAATCATTGTTGGTGGGAGCATCACCTAGTACATCACCGTTCCACCAACGTTGTATTTTCTGCGAAGACTTCAAGGATTGGAGTGCGATGAGTGAGCTCATGGCTCAGAAGCGGGATCCCCAGCATATGCTTCTTCCAAACTTCGATCCATGATGCCAGAGGCTGGTCGTGCAGAGCTTCTCATGTGATCTTAAAGGACTCTGCGTTCGATCTTTGGGGCTCTTCAGTCGTCTACCGGGATTCTATCTCAACATCTCCATCTCGATCCGAAGATGATGTTCTCACAGAGGCTCTGGATGATTTTGCATTTGCCGCGTGAACTACAGCTTGCAAATTCCACAAGCGGCTCGGAAGATCTCCGGCGAGCAACAAGACGAACTCATCTCACACCGATGCAAGTGCAAATCAGTTGAAGAGCGAGTTTAACCAAGACCCCATCCATGCCATAATGTGAGCTTCTCCGCAAGGAAGTCGGCCTTCCATACAAGCGTGTTTCAACTCTGGTTTTAAAATGCGCGAGCCATATCGGAGCGAAAGACGCGCGGTGGAGTGACCAGGACTCTCGCGATCCGGAGAACTTCACTGGGAAATTTGTGATAAGACGTTCGCGACGAGTCTTTTGCTGCAAGACCAGCTGTTTGCCGAGCAGCACATTGAATTTTTAAGGAATAATCTGAAACGGGAAGGGGTCTCCGCAGTGGACGACCGCTGACCGAGTGCTCTCCAGAGAAAAAGTAAGAATTTGAATTTTTATGTAATTTAATTACATATATCATTACCCTATATAACCTTAAAAATATTCCAGAGCAAAGCTTCCGAACGACGCCCGCTGGGTCTTGCCAGTTTCCCGTTCCTCGACACGTTCGACATTCACATTTAAGGAATACCCATCGCCTTTCTGCAGGCTGTCTGATGAGATCAGGATTAAAAGCAGATCACTGATGATATGACGGCTGGAAAATCGCGAACCACGTTCTGCCAGGACGGTTGCTCGACAAGTTGAAAGAGTCGCTGCCCGAGGATGAGAAATCAAATTGACAGAAACCCAGAAAGACGTTAGCTTTTTTTTTTTGGGAAAAATTTAGAACAATTTGGCAATTTCAGGTCGGATGGGCGTGCATGTACATTTGTCTTCCACTAAGAAAAAGAAGCTCCGTGAGCATCAAAAAGTATCCCATGTGCAGTGATAAGGTGCGCAAGAAATTAGGAAACGGGCTTGAAGTTTAGCTCATAGTTAGTCGTGTCAGACTGTCTTTGATCTACGAAACATGCGGGAATTGGAATTTCAGAAAAATTGTGAAGACTCAGCAGGAACGTTATTAACCATCGACGCAAAATCAGTTGAGATGTCTGCGTCATTTCTGCCGCATTTTTTGTAGAGACGATCTACGTAGATCAAACCGAAATGAGAGGCACGTTCTGAATCCACGAGCTAGGCTTAAGCTTATGCTAAGCTTAGGTCCTTTTGTCAGGTTTAGACTTAGGCTTATGCTCAGGCTTAGGCCTTTTCTTGGCTTAGGCTTGGGCTTAGGCTCAGGCGTAGGCTTAGGCTTAGGCTTAGGCTTATGCTAGCTTAGTCTCACAATCAGTCTTAGGATTAGGCTTAGACTTAGGCTTAAGCTGAGGCTTAAGCTTAGAGCTTGGGCTTATTGGGCTTAGGCTTAGGTTTGGGCTTGGGCTTAGGCTTAATCTCAGGCTTAGGCTTAGGTTTAGGCTCAGGCTTAAACTTAGGCTTAGGCCCAGGCTTAGGCTGAGGCTCACACGTGCTCACGTTCTTAATCATACAAGATCAGCTAAGAACTCTGCGTCTTTTCGCCCGCATTAGTTTTGTAGATCTACGTAGATCAAACCGATGAGGCACTTTGAATCCACGAGATAGGCTTAAGCTTAGGCTTCCTAAGCTTAGGCCTTTTCTCTCGCAGGCTTAGGCTTAGGCTTATGCCCAGGCGTAGGCCTTTTCGCGTAAGCTTGGGCTTGGGCTTCGGCGTAGGCTTAGGCTTAGGCTTAAGCTTAGGCTTAGACTTAGTCTCACTATCAGTCTTAGGCTTTAGACTTAGGCTTCAGCTTAGGCTTAAGCTTTTATGGGCTTAGGTCTTAGGCTTAGGCTTAGGTTTGGGTTCTTACGCTTAGGCTTAATCAGGCTTAGGCTTAGGTTTAGGATCAGGCTTAAACTCTAGGCTTAGGCCCAGGGCTTAGGCTCACACGGTCTGTTTCCCACGTTCTTAACCATACAAAATCAGCTAAGAACTCTGCGTCGGTTCTCTCTGTTCGGATTTTTTGTAGATCAACGAACTTAGGATCGAGCCGAAATGAAGCACTCTGACATCACGTGGGCTAAGACTTAGGCTTAGCAGCTTAGGCTTGGATCAGGCTTAGGCTTAGGCTTAGACGTAGGATTAGGCTAGTTATAGCTTGTAACTTTTTTAAATCTACCCCGAGTCAAAAAAAAACAATTCAATTCCAGACGCTAACCATGTGCAAACCCACAACTCGTGCAAAAGGTGTCAAAGTGATTTCTGTCTTCAATCCGAGTGTGATATCTCAATTCCATCTCTCAATCCTCATACTACTACTACCACCACGACGATAACAAAACCCCCCCCAAATATCACCTCATGCATTGCATTTGCCGTCTCACTCAAGGACCTATTTCCGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTCCTCTCTCTCTCTTTTCTTCTCTCGAAAAAACCACAACTCCATTTTTCCGTTCTGAGCTAACTATCCCCCAAAGTAATTTCTTTGTAATATCTATATCCACTTTTTTTTCGACCACACTACACCATATCCCGCCGCCCATCCCCTCCCCCCCCACCGCTTTATGACAAAACTGGTTTCGCTTTTGTCTTCAATTTCACACCAACCGCCTGCAGCTTCTCATAATAATTAATAATTTTTTTTAGCATGCACAATGATTTTGATAAATATATGTATATAAAGTCATCTAGGATTGCCCCCTTTCTAGGATATGTTTTTTTTTGCCATCATCACACAATTTTCCGATTTCAATGATAAGGATTATATCTTTGTCCGTTGACACATGTAGATGTTCCTGACCTTCCAATTTTTAATAGATTTCCATTACTAGTTTTTTTCAGGCCTCACTATTCTATTGCAATAATTACTTGGATGCGATCCATGAACGCAGTCAATAATAGTTCAAATATTTGCACTTCTTTTTTGCACACTAATTCAAACTCACGCCAGGCTGTCCAAATACGGTTTGATCTACTAAAAATGCGGAATGAATGTTTACTCCCAACAAAATGTGACATGATCAGTTGGCACGGTTCTTTTTTAACCATGCGATCGGTTGAGTAGTCTTGCGTCTCTTCTCCCGCATTTTTTGTAGATCAAGCCAAAATGTGACACTGGACAATGACACAACGTGTAGACTAACATTGACTGACACCACGAATATCATATTGAAACTTCTTGAAATCTGTTCAAGAAAAAAGTTATGAAGGCTCAAATGGCCTAAAATTCGCTAATTTAAAAGACACTTAAAACGGTGTCTTTTTGAATTTTTCCGTCCTTTTTTTAAACATCTTTGTTCATAAAATTTAGTGCTTACAAAATGGATGTTGGAACATTTATAGGATACGTTCAATTTTGCCATTTGAAATTGAAATTCGGAAATTTCAAAAAAAAAAAAAAAAAGTGCGAAGCCAAAATTTGTTTATCCAAAAATTATCGGCAATATTGCCGGTTTGCCGGAAATTTCAATTCCAACGACAAATTTGCCGAATAATGGCCGCATCCATTCCTGCAATTTGGCGATTTGCACCGATTTGCCGGAACCAGCTAACCTACTTACTAACTTGCTAACAAGCTCTTCAAGGTTTTTAGTTGATGATTTTCAATAGAAAATTCAGGTGTTTTCAGGCAATTTCGAGAAAGCAATTCAAACGTTTAACAAAAGAAAAACGACACTTTTTCCTCTTATTCGATTCTCTTAATATCTCAATTTTGCCTTATAAATTTATCCTCTCCTCACAAGGTGACACACACACACACACGCACACACTCGTTTCTGCTGCGAAAAAAAGCTATGACCTAACACGCGCCTTCTCGCGTAAGACTAAGATCCACTGAAGACATCTGATAAGAGTGGGTCCGCCATTGTCTCCAGAAAATTCTACACGCCTCCGCCCGGTAGGGGTCCCACCTCGTCGCTTCACTTTTGTTTCTCAAAACGATTCCATCGGCTTCCGCTGGCTTGGGCCATTTTCTCTTATACAACTGGCCATTCTTCTCTTATTGCTTAACATCATGGTTATTTAGGAATTTGTTCTACCCTGACTTGAAATGACTGGACGGCCTATTTTACTTTGATTGACTCAGAAGACTACTATAAGCGGTCATTTGTTGCGAAAATTTCTGCCTTTAAAGGTGGAGTAGCGCCATCGTGGGAAAATTGCTTTAAAAGGGCGCACGCCTATGATACCACACGAATATTATGTTAGAAAAATTCAGGGAAAAAAAATTCTCTAAATTTTATATGATTTTTTGAAAACTGAAAAAATCTAATTTTCACTTAATTCTTATGTGAATTACCGCTTGGATTTGCTCGATGGAGCGCCTTGCACGTTTTTAAATCTATTATCATATTTTATTTGTACTTTGTATTTTCCACGGATTTTTAATGTTTACGGATCATCTTTTTTTCCTTGAATTTTAAAAAGTCAAAATCCAAAATGCAAATTTTCGATTAAAAACAAGCGTACAGGTAAATCAGTTAATCAATTCAGGTTCATTTTTACGCCTGTAAGCGTGCTTTTTAATCCAAAATTTGCATAAAAAAAATTTAAAATGGGTCGAAAATAAGAAAAGATAATATAAATAAACTTAAAAACATGCAAGCGCGCTCCATCGAACAAATCCAATTTAAGGAGGTATTTCAATAGGAATTAGGAGCAGCAGAAACTGAGATTCTTTCAATTTTCAAAACAATAAATCATATGTAAAATTTGGAAAATTTTGATTTAAAATTTTTGCGTCATAGAAAAACCGGAGTTCCTCGCTTTTTTTTCATCGAAATTCAAAAAAGTAGGCGTGGCCCTAAACCGAACAGCTGTTGTTTTGTTATTGCTCTTAAAATTTCACAGCCTCTAATTGGTTGAACACGCCCACTATTCTGAAATTGGCCCACCAATGACAAATCGCGAAACTTCTTGTTTTTTCCGCAGACTATGGAAGCGTCCGCACTCGGGATATTCCCGCATTTTCCGCCAGACTATGGACGCACCATTATCATATCAATTGGGTCATGCTGTGGTACTATAGGCATGTTTTAAAGCAAAATTTTTTCCCCACTGGCGCTACTCCACCTTTAATGCATGCTGCGTCTTTTTTATTCGGTTCTGGCCATAACACACAAATTTTCTCAAAGTTTAGGAATATATAGATTTAAGGAAGAAAGTTTTTAGTTAGGAAAAAATATAGTCTTCTTCATGTTTTCTTTTTTTTGACAATATTCATTCTTGCCATCCGTTTTTTTTTCTGCAACCCTATTCGATAAATGTTTGCTTGGACGATGTAAGGTGCTTTGAACACTCGGCATTAGGGCTTCTTGCCCATTAGACCAAAAATATTAACTTGTATCAGAAGTTAGGCAACTATACGTTGGCAAAACTTGGATTCAGGCAATATCAAAGTTGCTAACCCAAGTTTCACCCAATTCGCAAACTTTGGCCTAAACTTTTTTTGTACTATGCGCAGAAGTTCCATTTTCCAATCGCCCCAACGTTTGCCCATCTTTTGCCCAAGTTTAGCCAACTTCGGTCCCAAGTGAATATTTTTGGGCCATGGGCGCTAGAACATCGCCGAATGACGAGCTCTTAGAATTTTATTTGACTCTATCCGATCTGCTAATTCTCAAAAATCCCCCAATTGCCAACCATTTATCAGAATGGGAGTAATTGGGCGATAGCGCTCAACGTGCTCGGCTTTGGCCGATAGTGCGCCTGATTCCCAGAGGATTATGTGGACCTGGTACTTCCTATGAAAAGCTGTATCCACCATTTCACACGCTAAACGTTTCCTACTCATCTTGATTAATTCAGTGAAATACTACAGTCAAATCAGGTCTTCGACAATTGTTGCTGAGTCGATCTTCTACCGCACTTCATTGGTGCCAAAACTGAGACGAACTTTGATGTTCCGCTCACCTGCTTGAGATTGGAGACTAGCAGGAAGAGATGCTCGTGTGGATGTCACTTCGGTGTGATCTTTTCCCGAATAGATCGTGTTGTTCGAGTAAGTTTGCGATTCTATATGACTTGTCAACGTGGTGTCGGGCTGACCCATTACGTTTTGATCTATAAAAAATGCGGGAAGTTTATGACCAGAAAAAAATGACGTCATCACATTCTTAACCATACGAAATCACTTGAGCAATCTGCGTCTCCCATTTCTTCTCCCGATTTTTTGTAGATCTGCTACGTAGATCAAGCCGCTGAAATGCAATTATTGAAATTCCAGCTTGCTGTCTCAAAATAAGAACCAATCCCACTTGCCTGCTGGGTAAGATCCGCCACCTCCCCCACAAACCGTGATGCCAGCCAGCCTTCGGCCCTCTCTTTGCTGCCCGGCAACCCCAAACTGTTGCCCGAATGTCCACCCAGCTGCCGAGTTCGTCGCCCCGAAAGAGTACGAGGACGAGCAAGGCAACCCTGGAGGCGTCCCAGCACCACCAAACCCACCAAGAACTTGCTGTCCTCCACCAACACCTGCTCACCATCGCCACCACCTCCACCACCACCGGCTCCGGAAGCTCCAACGCAATGCTGTGGATCACAGCCTTATAGAAGAACACCGTGCAGGTCGTCCGGATGTCCGAATGGAGATTGTTGATGCGGAAGACCTTGCTGTTACAAGCGGACAGCAGAACCCCACGAATGTTGTAATCAAGGGCAAAAGGCTTGCAGCCCACCAGAACAGCCTTGCTGTCCTCAGTTGAAGCTGGATAACTGCCTCGATTCGGCCCCACCTTGCCTTCGCGCCTGTCCATCGTGCCTATTCCTGAACTGATGCTTGGGAAGAGAACTAAGAGAGACTGGGCACCGGGGCTTCATATGCCACCCAAGTAAGCTATAAGTTTAGATTTTCACCTAGTGGCAGGCTGTCTCAGAGTGGTTTGATCTACAAAAAATGCGGGAATTTCTCGCCCAGGAAAATGTAACGTCAGCATCAGGGCTGGGACCAAGAAAAAAATTTTACCAAAGATAAGTTTAAAACCAAAAAAACCAAAAAAAAAAAAACCCAAAAAATTTTTGATATGCTTAAGTTGATTTTTAAGCTGGGGTTAGTAATGTTGCAAAATGGTAATTATTAAAATACATTTATGCACAACTGTGTTAAAATACATGTTTTAATGTATTATAAAGATTAGACTCTAGTCGACACTAGACACGGAACTTTTTTTTTAGATTTTTGGTCAAAATACCAAAAAAACCAAAAAATTCCCAACAACATGTTCTTAACCATGCGAAATCAGTTGAAAACTCTGCGTCTTTTCTCCCCGTGCGATTTCGAAGATCAAACCAAAATGAGACACTTTGACACCACATGGGGTATTTTCAAAACGCTGAAAATAAGTAAAATAAATAATAAAAATTTTCAGTCGGACTCCTTGGTCAACAATCCCCACCGACTGATTACAAAGCCGGTAAAGACCATAATAAAATCAAGTGAACTCCCGCGTTGCATCTGGAACCAAGACATCTCAACTGTCCGTCACCAAAAAGCACATCGAACTATCCTCTAACCACGTCCGCGGAATCGCCTCCAACAGCCGGAAACGACTTCCGAAGAGCCCACGTTCGATTCAAGAGCAACATTGTACTTTGGAAATGGACCATGCCAGCTGTGTCTGAACGGAACTCTCAGAGAACCAAGCGGTCACTCGCTTATAGTGTTCGTACCTACCTACAACCACAATACTCTGATTGGAACCCGTTCCTCGGAGATCAAAGCCATACGACCGCAGTCGCCACTCTCCACTCGCCGGGCACAGAACTAAGAGAGCTGGCGTGAGTTTGACTCATAGAAATTAACGTAGCTGAATTTATTTTTCCAGTGCCTTCCTCATCCACAATGTACCCCTGCATGTCCGTCGCTATAAGAGAAACCGGATCGGATTCCAATATTGTGAGCTCCAGGCAATGGACACTACGGTAGGAAGAAGCGGGATGGGGAGCCGATAGAGATCTGTGCTTGAAAATACAGAAAGGTGAAGATATGCAGATGAAAAGTGTGATAACGATGAGTTCAGTATTAATGAGCGAAGCAAACGACAAGCCTACAATCCAAAAGGACTTGATTTTGGATATCGTGAAGCTCCTATCCAAGGCCTCCTTCAGGTGGCAACAATCCAGGCGGAGGATGCATGATGCTCCTAGCCTGTGTTCTGGCTCAGAAGAAGAGAAGAAAGAGAAATGAGATCGGCTCGACACGTACTACAAAGCTGTGGAGCAGCACAAGAAGCCGGTGGAAGAGTACGAGAAGGCGATGGAGGAGCACAAGAGAGTCAAGCGGCAGTTCTTCGCTCCGGATAATGCTGCAGTGTTCCTGTCGGGCATGGGTGTCACTTGCCTTGGCACTAGCAGAAAGAAGAGAGAAGTCGAGAAGGTGGAGCATATGAGGATGAGCGAAGCTATCTATCAGAGCAAAGAAGGGGTATAAGGAAGGATATGATGATGATGATGAGGTGAGAGACCTGAAACTTTAGATCCTGTAAGAACCTTTTGAAAATTCCAGAAAAAAAACCCCCTAATTGAAATTACGCCCGCACGCGCCACTGAGATACTGTATTCGCGGCGAGACCACCCTACTGCACATCTAAGAAGTCTCCCAACGCAAGTGACGAATTTGGCCTAAAATGGACTTATGGGATTTCCACAGTTTTCACCATTTTTTTGACACAGTCGACGTTGACTTTTTACACTCAAAAAATTATTGGCGTGGTCATCTCAAAACTGATTTCAACAATTTACTGGATTTTACGCGTGTACTTCATAGTGTCACACCAAAAATTGATCTGGTTCATGTGGTGTCAGCGTGTCGCCTTTTGGTTGATCTACGTAGATCTACAAAAAATGCGGGAGTTGAGAGACGCAGAGAACGGGCGCAACAATGCGGATTTTATCTTAAATTTTCATATCAGGACGACAGTGAATCCTCGGAGGAAACCGAACCCTCTAGACGCAGAAAGCAACGCCGCTCCTGCCAACAAAGTTAGCCGACGATTGCCTGAACAACGTCGAGTACGCAGTCTTCGAAAAACTGGATACAGACAAGAGAACCAAACGAGAAACCGTGTTCCGTCGTAAGAAGTGGACCGCCAGGTGTGGCTCCTTCATGGGCTCACCAGGGCCACATCGTGTCAAGAGAAACTTCGGGCAGCCTGAATATCAATGTCTCGGAGCAGAATTGCACGGCATTCCCACAGTGTCGGCAAACAGTGAAGAGACACTTTTTGGGAGAAGACTGTAACATCTGTACACAGGATACTGGTCTGAGGCGGAGGAAGAGAGTCTTCGGAACAGCGGTAGGTGTTGGTTTAATGAGCTGCCGTATCTTATTCCGCAATGCTACCCATGCCCAGGAACAAACGTTCATAACTTGAAGCGACTCCCTCCGTGGATATGTCTCACATATCACATAAATACCACCTCGTAATAATAATTCAACATGACTAATAACAAATAAGTACATACATACATTTATATTAGCTTTCAGCACCCGTAGTCGCAATGTGGTGCAATAAAGATATGTGTAAAGAAATGGGAGATGTAGTAGATTTGGTCGTTATAGTGATCGCAGATCTTTCCTCTTTGAGCCGGAATATTGACTGGATTGGAGCCAGGAGATGAACCTCGCGGGGGCAAATGATGCAAAGTAGGGGTGAAGCATTGCACTGGCTGCGACACGGCTTTCCGGGCGGAGCTGTAATTTTGAGGGTTACAAGACATAGGTGTAGCTCGATGTCGATTCATTTAGACTAGCATTGAAGCCTTAAGCTTTCGGCTTGAGCTTGCACGTACTCAAAGACACGGTTGCTGCTCAATATAGCTCGCGGAAACTGATTTGTCACAGGTAAGATAACTAGTAGGCCTGGACTGACTGTGGAGTAGCGCCAGTGAAAACTTTGTCAAAATACATACATTATGACGGTCCGAAAAAAAACTAAATTTCATAAGGGGTAAAACCAAAGAATTAGATTTTTCACAATTTCAGGTCAAAGTCTTGGCAAACTGCTCAAAATAAAAATGAGCAATTGAGGAAATCTAGAACAATCAGTCGCATGTTCCGACCCCTCCACAATATTTTAATACACATAATTAAAACACAATTACAGTATAAAAATGTATGAAAAAAAATGTTTTTTTTGGTGAATGTCGACTTCCAAAATTATGAGTGGTAATATAACAGTAAATAAAAAATTTTCAAAATTTTTTTGATTTTATTATATGATATTCGGTCTTTTCGGGAGTAACTTAAGGAGTGGTTTTACAAGTCTACTTACCTGAAGAAGCATCCCCAGAAGTTCCTGTACCAGTTCAGAATCTACGTGAACATCGGGTTCCCACCGCGATGAACGACAACTCCCGATACCAACAGTTCAGGGGTCCTTGTACCCTGGTAATGTCTTTACCTGAAATAAACATCTTTATCTCTAGATTTAGTTAGATTCCCTCACCTCCGGCCACTCGACTCGTCTGGAGTACCCCGAATGCTGAAGATCCCATATCCAATTCTGGTCCTTGGTGCCGCGGTAGTCAGAGGGGTTTCCTTGGATCCCGGGAACAAAGCGGCGCCCGTGCACATTTCAGCGAAGATGCAACCGACTCCCCTGCAATGTTAGTAGATAGAGTGTACCTTTTATAAAATACTATCCTCCTAACACATATCCAGTGAAGATGAATATGAAGTCGGTACTTCCCATGAGAACATGCGGGCGGTACCATAAGGTGACCACCTCGTGAGAACATATGTCCTACTTTTCCGCACAGATTTCGCCCTGGCTAGATCAAAGTCTGCGAGTCTTGAAACGAGCTCTCGTCCTAGCAAGTTTTGTGGTTAAATCTCTGAAAAAGTTTTTATCGTAAGTGGCCGCAACGGCGCCTCCGCCGACTCAAGCGGTCGCCGCGCCGGCCTCGGAACCCCGAAAATGTCCGGCGCTCCAAACAACCACTTTTTTGCACTACGTTGCGCACAAGGCCACTCATTTCACGCCAAGCTGCGGAACACCGAACGTCTCCCCCGCTCCAAATCACTCCCTTTCGCAATACGTTGAGCACACACAAAGCTGGGGAACTCCCATAATTACCTCTCGGCCGCTCCGAGCAACCACTTCTCCTAGCACTTCATCACACAGCAGCTTACTCATTTCACAAGTCGCCGAGGTAAGCTGCGGAACCCTGAACGTGTCCGCCGCTAACAACTCCCTTTCGCAATACGTTAAGCACACACCAACTGCGGAACCCCCAACGTGTCGGACGCTCCGAACACTTCTACGCCACTTCATTGCGCACACACCAGGTTACTCGTTTACGCCGAGCAGCGGAACGCCGAACGTGTCGGCCGCTCCAAATGCCCACCTTTCGCGCTTCAATGGCGTCGGCGTGCGGGCCAGGATTTCGCGCCTCGCTCGGATGGGAGCGCAGTATCACCACTCGGGAGCAGTTTGCAAACTAACCTATGAATCTTCTCCTATGACAAAAATCGAGTCCGCGGATTGAGAGGACAAGCTTGATGTCAATGCTATCCAACCCATAGACGTTCTGCTCCAGGTACTTGCTCAAATCCATTTTCATGTACTCGAACACATAAGTTGGTTGAGGTCGTTGATAGAAGATGTCGTGCAAAGAGACGATTGGGATTCGCATGACGGAGGTTTCTGAGAAGCGAGGCCGAATTTCACGGATAGCGGTGAATGGGAGACGTTCTTGAAATTGAAGTTTGATCTCTAGTTCAAGGCGACTAAGGGTAAGGACCTCTGAATATAATTGAGTGGTAATATCAGGTTAACTAGCATAACTTCCTTGGACTCGCACTTATACACCGTTGCATAAGAGCCTTCCCCTGTCAATTGTACAGATCATTCACATCCTGCGGTGACGTACTTCCTCCTTCGAGGAAGCGTGAGCGTATTTGGATCGTAGTATGCTGATCGTGGTCGACGTCTTCGAAGATGTGTGAAGCGGCCACAGAACTGTTGCTAGATGGTGGAGGTGGCATTCAAGGAGAGTTCACGCTTGTTTAGGGGCACGGACATGGTTTCAGATGGATTGCTTGAGCGGGAACGTGATTGCGGCTGATAGGGTATTACTAGGTTTGACTTGGAAAATTTTCTTAGAAAAACAGTTTAGCGGGAAGTTTAAATTTGCTGATTAAAAATGTTGGCGTAAGTGAATGTCGAGGAAGTACCCCATTATGGTTTGATCGACTACAAAAAATGCGGGAGGACAAAGACTTTGCAACTGATTTTGCAGGATTAAGCTGACGTAAATTTTTCCTGTGGGAAAAATCATAACCCCGCATTTTTGTAGATCAACCGCCGCAATGAGACAGCCATAGATGCCACCACGTTGACGGGATATTTAAATTTTGAGAAACTCAACATTTTGGCGGGAAGTTCAAATTTTCTGAGCAAATTTTGGCGGGAAATTGAAATTTTCTGACAAAAAAATTTTGGCGTTGGGAAATTGAAATTTTCTGACAAAAAAATTTTGGCGGGAAATTGAATTTTTGACCAAAAAATTCTGGCGGGATTATTTTCTGCGAATTAAATTTGGGTAGGGAGAAGTTCAAATTTTCTGTATTTTGCGGGAAAGTGAAACTATTGGCAAAAATATTTTGGCGGGAAAATCAAAGTTTCTGAAAAAAATCACTGTTTGGCGAGAAATTGAAATTATCTGACAAAAATATTTTGACGCGGGAAAATTTTTCTGAGAAAAAAAAATTTTGGCCGGAAATTCATAATTTTTTTTTTTATCTATGAAAAGAAAATTCTACGGACCGGAAACGGCCCAACCACGGCTCAAGAGCCGTCTCGGTCGGTAAATGTGATTTTTGCTCTAAATAATGCATTTAACGACGTAAAAATGCTTAAATTAGCCAACTGGTATCATAGGTAGTAAAAAAATCCGTTTTCTCAAAATTTTTTTCCTCTTAAGGCCATTTTTGTGCATTCCCCGTTAGTTTGCCTTGGTCCGTCGCGCTTTTCATATCCGTAGTTCACCCGTTAATGGTCCGTTCCCTATGAGGTCCAACATCGTCGTAAACGGAGAACCCGTCCCGGCTTTGCCTGTGGTCAGATATAAGTAGTAAGAGTGGTGTCAGACTGCCCGCATTGGATTCTACGAAAAATGCGGAAATTTTTCCCCCAGAAAAACGTCACGTCAGCACACTCTTTAGATAACCATGCGATACCAGTTGAAAAGTCTGCCGTCTCTTCGCATTTCTCGGAGAAAACCAAAATGAGGCACTTTCACAAGTTACAACAAACTTAACAAGGTGTCGAGACTACGGTAATTATAGTCTTACATATACAACCTAATAAGAATCTCCATTACCTCAAAAAGCTGAAAATTTATCTTATATTAGGATGTTCTGGTGTGCTTCCACTGCCGGACCCCGATTATGCCACATTCACATGATTGGAGTGCCATGATTGTGTGCGATCATTTGTTCCCCGTTTTTCGAGATCGGAGATTTCGTGGAGCCTCCTGAAAAAACAGAAATAAATGTGGAATTAATATGGGGGCTCAAATGTTTTCGGAACTAACCTCTTTTTTGGGAACTCTGGAGAGCATTTTTGTGTAAACTGACTAACTCGTGCCACCCCCCGCACCCCATAGAATAAATTGGCTAAAATTTCGAAAAAAAAAACTCGCCACCGCCGTTATTCTTGTATTTCTTCTCCTTATTCCGACTCCGACGCAAAGTGAAAATTGACGAGGACGGCTGGAACAGGATAATTGTTTTGTGTTTGTTTCTAGTGGAAGAGATGCAGAATCGCCGAAGTTTAGAGCGGGTGGCGTGAATTACTGACCTTCCGGGTGCTCGGCGAGCCGTCCACGTCCTGAATTGCGTTGGCGGCGACATTGTGGTGATCTGGAATATGTGGATCGTAATCGAAGCCTAATATTTAGGCTTAGGCTTAAGCTTAGAGTGACTTAGGCTTAGGCTTAGTCGGCTTAGGCTTAGGGCTTAGGCGGCTTAGGCTTAGGTTTAGGCTATGCTTAGGCTTATAGGGGGCTTGGGCCTGGCCTTAGGCTTGAGCTTTGGCCTAAGCTTAGGCTTAAGCTTGCGCTCTGGCGTAGGATTAGGCGTCCGCTTTGGCTTTGGCTTAGGCGTAGACTTAGCCTAGGACGCTTACAGGCACCCCCTAGGCTTACAAGAAATCATATCCAGTTACCGACCGGTGGCCTAGGATTTCAAAAAATGACCCTTTTTGAAAAATCGAATCGAAATATCGACGAATTTTGTTTTTGAGGCGTTTTTTTAATTTAAATTTTTATAATTTTTATCGGTTTTTCGATTTTTCATGAAAATACCAAACTCACCCTATGCAAGTTCGCCGACGACTTCGAATAACAGCGGTGAGCTGTGGATGCTGTATCATAGACACTGAGCACGATGCTCTCATAGGCCTCTCGGGTCCTCCTCCAGCCCAAACCTCCAATTTGGGATAGGTTATTTTTCCCCACATTTGAAAGATGGTATGTCTGCAAGTGACATGTTTTTTTGGGTGGGAAAAAAGAACGTGAACGAATAATTTGGATCAGCGGGGAATTGGGGGGGTGTAAAAAAGAAGAGCCGCTTGGAGTAGGGGTATTACGAAATGAGATATAGAGGAGCAGCCGGTGTGACGGCGGGGCGTTAATGGGTTACTAAAGCCTACACATTCCCATTTTCAGTTTGAAACAAGGAAAATAGAAGAAAAAAAAGAGATGAACAATGACTTACGGGTGGGTTCGGTGAAAAACAGGGGCAAGCAGGAAGAGTGAGGAAAATGGATGGTTGGAGGAGTTTTGGCATTTCTATTAGGCCGGGAATCTTTAGAGACACCTGGACTGTCCCATTACAGTTTGATCTACAAAAAATGTGGGAATTTTTCGCCCAAAAAATTTTCAACAAATTTAGATATTTTTTACATTTTTTCCCCAATTTTCAGCCATATTTCAGCCATGACTGTCCTATATTTTATTTTCCGGCAAAAAAAAATTTTCTCTGAAAATGTTCGAAACTACTTAATTAAGCAAGAAGGCATTTTTTCGGAGATCAATTTTGAGTCCTCTAGAATTTCTATTATCCATTTTAAAAGAGTTTTAAAATTGTAATTTTTTACAAAAATTGCTCACTTTTGCCACTTTCTAATAGTTTTCTAAACCTAGAATTTCTGAATTCTGCATATATGAATTACCCGTTATCAATAAATTTAGACAATTATTTTCATTGTTTCCAAAATTTTCAGCCATTTTTCAGCCAACTGTCCTATTCTTTGGGCAAAAAAAATTTTATAAGGAAATCGGACTACATTACACAACTTCCATGTTTTCTTCGTAGATTTAAGGTCCATGACCACTGCTTGGTGGAAAAGTTTTCCGAGTATTTAGGTCACCGATTTGAGTTGGAAGAGTTTAATCGCATTACTCCCCAACTGTGATAGAACTTCAAAAATTAATATGCAGGGACATCACTCAAATATCACATGTCAGTTTAAAGGATCACGCTGATTATCCGAGTGGGTCTCGCCACGATCCAGGTGCTAAATTTTCACAGTATTTAGTATGTACCTAGTGGCATATTTCTAAACAACACGCGCATAACATCGGAGTGTCGTTGCATAGGCCACTCTGAGAAAAACATAAACAAATGTGTGATAGAAAAATTAAACCACAACTAACGGATTTCTGATCACTCATAAGTTGAAATGGAAGAGTTTTTGCCGAACTAGGTCACCATATTCGGGGTAGATTTACGGCGCGTCGCGGCTCGACTTTGTAAAACTAAATGTATTTGTCTGAGTACACGACTTTCCCAGGCGTTGTCCGGCAGATTGTCAATGGAGCGCAACGTAAAGTTCAATGAGGAAGGCCAGAACCCCGTGACCAGGGATTTTGAAATTTTGCAGATATGAACAAAATGACAATAACTTAAAATGCATTAATCCAGCGGACAAAGGGAAGAAAATAAGTAGTGAAAGAAGTGAAAAAAAAGACGGACGGGGCTTCTCTCATAAAATAGTAATTGGTCATTCTAAGTGTGCCTATTGTCTTAATCCTTATTTTTTTTTCTTGGCTCATTTTACCTCAAAAACCAAATAGCGCGAAGAGTTCTAGAGAACTAGGCCACGCGGAGAGGGAAAAACTGTCACTGGAATTTCTACGCTAACACAAAATTTGTCCCAGCATACCTACGTGGCAGTAAAAGGAGAAAGTTCGGCCACTTTTCGGGCTATCAAATTTCCCACTTTCACCAATAAAAAAGAAACCACTTGTGGAAAATGGCCGTGCATACTAATGTTCGGTCACACACGTTTTTAAAACTTTTTTGCTCAAATTGAAGTACAGAGACCCTTCGATGGGTTTTCACTACTTAGCTACGTGTACAGAGAAAATTCGGCCACCAGACGCACTTTTATTCAAGGCCACACCTCCAAATCCTTCAAAGCTTCAAAAATTTTCTACGTGGCCGTGTACCAAAAAATTCGGCCATCATCTTTTTTTTGGGTCACGTCGCCAAATTCCTCAGAGCTTCAAATTCGAGATTTTCTACGTGGCCGCGGGAGAGAAAATTCGGCCACCAAATCATTTTTTAAGGCCAAACCTACAAATCCTTCAGAGCTCATATTTTATCTACGTGGTGCCGTGTACGAGAAAACCCTGCCACCCAATGAATTTTGAAGGCCCCACCTCCAATTCTTCAGAGATCATATTTTCTACGTGGCGTGGCCGTATACGAGAAAATTCGGCCACCAAATTCTTTTTTAAGGACAAACCTCCTAATCCTTCAGAGCTCCTATTCCCTTCGTGGCCTAGGAGAAAGGTCGGCCACCAAATTAATATTTCCACGTCGCCAAATCCGTCATATTATGAGGAAAAAAGTAAAAAATAATACTAATAACAATTGAGGACAAATTGAAACCCCATATAAAAATATAAGATACTAGTAAATGATTAGAATGAAGAGCGAATAGGAGGCCAGAGAGAGAGAGGGGAGGAAATTGTGCTGTTGAAGACCTTGAAGAGAGATGCACAGAAATAGATAAATTTGAATTACAATGGGGTAAGGAGCCGGGTAACTGTCCCCCCCCCCCCCCCCCCCCAAAAAGTGCGAACAAACGTGATGAAGCGAAGCGAAAATCCGGAGGGGGGGGGGGGGGGGGGGCTGTGATCCAGGTTGATAGATTTAGCCAAGTGTTTCGACTTTTGGCCGAGTTGAGCTCTATGAGCCGGGCTCACCGGAGAGAGCCCATGGAGCCCCATGAAGCAGAGGGTCACGAGGTTTGAGACTCCGGGAGATAGACTGCACAACGTTCAAAGACTAAAACTTTTTTTTTTTGCTAGGTGAGGCATGAAATATGGAGCTTTTTTGCAACATAAAATCCAATTTTTGTAAAATAAGGTCAGATGACGTGTGTATAATCTGGCTGAGAAAACCTGAAAATTGATCTACCTTAATAAACAGGGCGCGGGTGTAAAGCCGAGCGTCGTTGTGATGCTGAATTATTGTTGAACGAGTTCTGGAATTCTGGCCCTCATAAATTAAATGGAAGACTTTTTGCCAAACTAGGCCAGGCCATATCTGGGGTAGATGCGCGCTTTTTTTTGGGCATAAAATTCCCGCATTTTTGTAGTTAGATCAAACCGTACAGCCTGACATCACGTGTTTTTGGCCCCGCTAAACAGGGCGCGGGTGTAAACATTCAAATATTATGTTAAAAAAACGCATGAATTTGAACAATTTTGCGTAGAATTTTTTAACAAAAACATACATTGAATAACTGATGCGAAACGAACAGAACTGCGTAAATTTTCTGAAATTGAAGGACAGGGGAAAAAAATTGTGAAATTTTGGACATTTTTCCCTACGACGCATTGAGCCACCCAGATGAGCAAATAAACCGGGGGAGCAGGAGGAAAATGGAATTGACAAAAAAGGCGGGTGAAGGAGGAGAAGCTCACGTATTTAGTATCCCATAGAAAGAGTCAATTTTCATTAAAACTGCGACAAGTGACTACCAGGGAGCAGTTGCGCTCTACCGACATAGTCAACCAAGGTCCACGTAGAATATGCCAGTCTGTCCCATTACGGTTTGGTCTGCAAAAAAATGCGGGAAAATTTGGCTCAAAAAATGTGACGTCAGCACACTCTTAACCATGCGAAATCAGTTCCCACATTTTTTGGAGATCTACGTAGATCAAGACGAAATGAGACACGGCACCACGTAAAGGTCCTTCTTACAGAGTGCGCTGGAGAGCGATTCAGGTGCCAGTTTTCTAAAAAAAAAATCTAACATGAGCGAAAAATGTGCGTCAAAAGTGGAGTTTCCTTTAGCGATGTAAAGTTTGGAGAAAAATTGAAAACTGTGGAGGAAGAAAAACTATTCGCAAGACCGATTAAATAGTATTTCACTTCTTTTATTTTTCAACTTTTTGCAATTGCTTTGGCAGGAATGGGGAAAAGGAAAAAAAAACGAAATCATCGATAAAAACACCACTAGTCCACCCAGAAGTAAACCTAGCTTATAGAAATAGGCCACCCTGTATGGAAGAATTTTAGGTCATCGCGTAGAAAAGCTAGGCCACCCTGTTGAACTGCTACGCCACGGTGTTGTACACTTAGGCCACTCTGAAAAAAATCTAGACCTCACTGTAAAAAATATAGGCCGCCTTGAAAGAATTTTAGGTCATCTTGTAGAAATTCTAGGCTACGTTTTCGAAATTCTACACCACTCTGTAGAAAACTTGGGTCAGCTACTACTCGACATACTAGGCCACCCTGCAGAAAACTTAGGCCATCTGCCAAAATCCTAGGCCATAGAAAATTTAGGGAATCTACCAAAATTTTATGCGACTATCTGTAGAAAACTTAGGCTACCTCGTTCAACCATGTTCAAGGCCACCGTGTAGAAATCTTAGGCTACCTCGTTAAAATTCTAGGCCACCCTGAAAATTACGTGATCTACCAGAAAAATTCTATGCCCAGAAGTAAACCTAGGCACCTTGTATAAATTCCAGACCACCCTGTAGAAAACTTGGGCCATCTACCAATACTCTAGGCCACCCTGTAGTAAACTTGGGTCATCTACCAGAACCGAACCTAGCCTGTTCCGTTACGCCGCATGCTAAAAAACGCAGTCCAGACCTCCCTGTAGAAAATCTAGGTCACTCCCTACAAAACCTAGGGCACCCTGTGAAAATTCTACACGTGAAAATTCCCTTCCCCAGAATAAACTAGGCCACCCTGTTAAACTCTTGGGCCACTCAGAAAAACTAGACCACCCTTATAAAAACCTATGGCCTAGAAAAAAGCTTGGGAAATTTTGTGGAAAAAGTTAGCCGAAAAGGAAAATCTAGGCCGCCGACAAAAAAGCTAGGCCACGTGGCAAGAAACTTAAGCAGTGACGAATGATACGAGAGGCGTATGTTTGAGGTCAAAAAGGGAGAAAGAAAAAAAGACGAGGCGGAATGTTTCTTCTTTCATTTCAAAAGAATCTCCCCGTCTCTCGGCCACCAATACTCTCACTACTACAACTAATGTTTTTAGGCCCCCCCCCCCCCCCCCCCCGGGCACTTAGCTTTTTTGACGGAAGATGCCACAATCGAAGAGGAAACCATAAAAACCCGCCAACGACCTACTCCTTTTTAAGGCCCGGATGCCCAGATGTATGAAAAAATCGGAGAAACTGAAGGCTTCTCCCTCCCCCCCCCCTCCCTTAAAAAATGATGAATTACAAATGGTGCCGCCCATGTTGACAGTGTTTGCTTTCCCCGTGCTCCGCCAGCTATCTAAAAATTCGGGGGAACATAACAGCCACCTTGAGTTACGTATACAAAGTGACAGGAGGGAAAGATAGAGGTGAAAGTGCCAAAAGGTAGTCGAGTGGTTCGAACAGGGTTTGCAAAATTTGGGCTGTGCGCGGCGCCTTAGACTACTGCGCCACGCGTGCGAACTGTAAATAGGACTGTCAGGCAAAATACGAACGTTCGGTTTTTAAAATCGATTGGCAAAAATGAAATGAATGAAGACACACGAATGACTCATAATTTTTGCATAAAGCGGCCTGGGTCTGGGAACTGGCGTTGAATTAAGCTAAATGAAGGAAAATTGAGGCATCTCCCGTTGAGTAGAAAAGTGAAGAGGGCGGCAAAAAGAGATAGGGGGGGGGGGGAGGACCCATTCATTTTACACTCCACACTCCACACTCTGACTTTTTGATACGAAGGACATGAGTACGAACACGCGAGCACAGAAATACGACACGTTTTCTTCTCATTTTTTTCATTTTGCAAAAGGTGATGATGATAATCGCTTCTAAGAAGAACGAGGGGAAGTGTACTAAATACTAAAATTGCGAGTGGATAAATTGAATTTTTTTATTTTCGGCTCGGCAAAACCTGAAAATCAGTCTGGAAGAGTTTTGGCTAACTTTTTGTTTGTTTAGAAACTCACTTTTCGCTGCGAAACAACCTGAAAGGATATAGTGGGCATGCACCTTTGAGCGCTACAGGCCTGTGGAGGGAATTCAGTATCTCTTGGAAGTCAGATTTGCCGATTGTTTTAACGCAAAACCTGAATTATAGAAAAGAAAATATGAAAATTTAAATATAATGTAATAAATTAAGCAAATTACATATCAACTGAGAAAATCTCCTGCTTGGGGAGAGAAAAATTTGTTGAAAAAAAGCCAGAAAATCGGCAGGAAAGCAATTATCGAGCAAGATCCTTTTTTAGGTGCAGATATCGGTTAAAAAGGAAAACACTATTTTAGCTTTTAACTATTTTGTCTTAAGTTCAATGTTATAACGCAAGAAACGATATTTCTCTGGCATAAATTTTAGGTCCTAGAAAGCAGATTTTCACGTAGATTGGTCTGAAAATAATATTGGAGTAATTTTTATTATTTTTCCTTGCATTATAAAATTACTTTTATTTCCCAAGTCTAAAATATTTTCCCGTTCTTTTATATCTCGCGCTTCTCCGGGATGTTGCATCCCATTCGACAAATGTGAGGAGTCTCGGAGTCGCTGCAAACGCGCTCCACTGGACACAGAAAATAAAAAACCAATAAATTGTTCGAATTTATGCAATTTTCTTGTAATTTTCTCTGTTTTTCGTTTTCTGCAAAAAAGACAAAATTTACAGGTAGCAATGGATGGGGGATTCATATCAAGGGTTATAGCATATGTGTAAGGCTAAAAACTAGGAAAAACTAGGAAAAACCCATGGAAAAATAAAATACTCTGAAATTTCAAACTGCTTTCAGAGCCTGGAATCAGCAGGCGGCTTCACAATATCAACAGCAAGGACAACAGAGTACCCGTAAGGCTCGAAAAAAATTCAAAAAATTCCGGGGAAAAAAATCCATTAAAAAGATCAAAATTTTCAATTTTTTCAGCGGTAGTGAACCCGTACGCGGCGAATCCATTATGGGTACGCGGCAGCACAGCTTCCAACCACTCCACCACCGCTAGTATGCCTTAAAATTGAAGAAAATTTGATTAAAAATTGAAAAAATGCAAATTTTCAGGTAGCCGATCCATACGCCGGCCAATTTCAGACAATTTCCATCTCAAGCCACCAAAATAGCGCCCAATCCCTACTTTAAAAAGCCACAAAATCAGCAGCAACCAATTTTCGCCGTGTTTTCCGGCTGCAAAAAAATTAAATTATCGATTTTTTAAAGGCTACGACGCGGCGGTCTACAATTACTCAGCAGAACACTCCGAAAGAAACCAACGGCGGCGGCGGCCGGGAGAGACAGGGATCTGGGGATATTAAACAGTACTATTGTGACGTAAAAAACGTGGAAAAAATCGAGTAAAACACAGTTTTTCAAAAACCTGAGAAGTTCCGTAAAAAATCCTGTTTTTTGACTAAGGAAAAAAATCGGGTAGCACTTTTAGAGATAAACGAAAGTGGGATAAATCGAATTTTGGACCTGATTTTGGGCTTGAAAGCATGATTTTTATCAGAAAACACAGTTTGTGTTTTTAAAAATCTGAGAAAATTTCTATTAAAAGTCTTGTTTTTGGATGTTAGCAAAAAAAATCGGGTTTACTTCATTTTTAAGGGAACAAAAGTGGCCAAAAGTTAATTTCTTGTAAATTTTCACATGCAGAATATTGAATTTATTAGGTTTTTTCCAGAAAAGTAGTTTTTTTTTCTACATTTAAGGCTTTTAAAACTGAAAACATGAATTTCCTGAAGAGGAAAATCGACAAAAAAACCCATCTTTTGGCCAAATTTAAATTTTTGAGCAAAAAAATCGGGTTTGCAGCACTTAAAGAGAACTGTAAAAATTCAATTTCTTGGAGAAAAAAGGAATTTTAACACCTAGCAAAAAATTCGGGTTGTCAATTTGTTTGAAAAAAAACTTGAAAAACCGGATTTCCAGTTGTTTTTTCATGATTCTCAAAAATCTCATAAAAGGAAATAATTTCGAATTTTTTACTGAAAATCGCAGAAAAATTGAAACTTTTTTTTCAATTCCGATTTAACAAACATTTTTGGTACGCTAAAAAACGGAATTGATTTTTAGCCTTTTAAGTTCGGAAAAGATGCTGAAGATCGAGTCGGAATTTTCTATTTAAAGAAATTTGTGCTGAAAAATTGATTTTTGTGCTCCAAAAACTGGAATTTTTGAAAAATTCGACAAAAAAATTTTTTTATTAGTAATTTTTTTAATTTTTCAACCCGCTTTTTGCCCAATTTTATTTTATTTAAAAATCGGGTCTACTGAACTTTTAAAGGTAGAAAAACTGCAAAGAGTTAATTTCTTGGATATTTTAAGGCGTTAAAGTCCAAATAAACATGTTGAAAATGGAAATGTCTACAATTGGTCGATTAAAAAACATTTTTTTCGCTAAAAAATTGAATATTTTTAGGCTTTAAGTCCAAAGAACAAGATGAAACTTGAATTTTTTTTTCAATTTAAAAAAATTTTGCTCCATGTCAGGCTCCCAAACACTGGAATTTTGGACTTAATCGAAAATTCGGACAAAAAAATATTTTTATTCGTTTTTAATTTTTTTAATTAAGAAAAATCCCAATTTCGAGGTGTGAGCAAACTCTCGTGCATTTTTGGGGTTAAATTGGAATAAATTATCAAAAATTTTCGAATAAAACGGATGGAATAAATCTGATTTTTGTAAATTTTTCGAAAACAAAAATTTACGTTGTTGGCAAAAATTAAATATCTCATGGAAGTCCAAAAACCATGTAGATAATTCGGGAGGAAAAAAATTGGGAGAAAAAAATTTTTAATTTCAGTAATTTGAAAAAAATATTTAAAGCTGGTGTAGTCGACTTTATTTATTGCTTAAGTAGACTCGAAATTGCCTAGAAATACCGAATTTCATAATGAAACTTCTTGAAAACTTCTCACAAAAAAAAAAGTTATGACGGCCAAAAAATGGACTATAATATAATTTTGAAATTTGAGCGACTTTTCAAGCGGCTGGAAACATTTATTCGCTTTTGAAATCACCGTCAAATTTTGAGTATACTGTGCATTTATGTTGCGTGTTTTCAACTTCATTTAGGTATTATAAAGTCAAAGGGCGGCGAGATTTTTAATTTTTAGTGAACCTGACGACATCGACTTTATCTCAATCGAGTTCAAAACTCAAGATAATTAAATTATATTATCAAAATTTGACGGTGATAAGTTGTAAAAAGGTAGTTTCTAGCCGCTTGAAAATCGGTCAAGTTTCAAATTTTAACCAATTTCAGGCCATTTTTTTAGTCGTCATAACTTTTTTTCGAGAAGTTTTCAAAAGGAAGTTTCATTTTGAAATTCGTTGTTTTCATTTTGAGTCTTATAAAGCTTTTAATAAATAAATTCGACTACACCGCCTTAGTATAAATATTTTTTTGAATTTTTTTAAAATTAAAATTTTTTTTTCCAATTTTTCGATTTTTTCCGCATTCTCCGTGGTTTTTGAACTTCCAAGGCCTCAAACAATATTCAGTTTTCGAAACTATTTTTTTTTCGAAGAAATTCCTATAAAAATCAGATTTATTCCATTCTTACTCGAGCAAATTTTTGATAATTTTTTCTTTAACCCTAAAAATGCATGAGATTTTATCACACCTTGACGCTAATTTGCTGGAAGTTATTTGTAGAATTTTTGGAATTATTAATTAAAAAAAAGTTTTTTTTTTTTTTCCGAATTTTCTACATGGTCTTTGAACTTCCAAAGCCTGAAAATGATTTTAAAAACTTTTTGCTTTATTCGGTTGTTTTTGGTTTTTTTTTTTAATTTAAAAAAATTAAAAAATTAATAAAACTATTTTTTGTCTGATTTTTCTATTAAAGTCCTGTAAAAAAATTCTATTTTATAGGTGTTCAAAAAATCCTAATTTTCAGGCCGTTTTTTGGCCTTGATATTCAATTTTTACACAAAAATTTTTTTTGCAGTTTTTTGCCTAAAAAAGCCCTCGAACAAAAAAATCATCTTTTCTCGAATTTTTGGAAGCAAAATTAAAAATTTCAAAAATATCAATTTTTTGGTGTTTTTCGGGTTTTTTACATAATTATTTTTTCATTTAAAAAGTTTGTAAATAACCATAAAATTTATGATTTTTTAAATTAAAAAATAATTATTAAAGAACACTCGAAAAACACCAAAAAATTGAATTATTATTTCAAATTTTTAATTTTTCTTCCGAAAATTCGAGAAAAGATGATTTTTTTTCGACGATTTTTGAGGCAAAAAACTCCAAAAATAAATTGTTTTGTAAAAATTTAATAAGGCAAAAACCAGGCTGAAAATTCGGATTTAAAAAAATAATTTCTTGCTATAAAATAGATTTTTTTCAGGACTTTAATCGAAAAATCAGACAAAAAATATTTTTATTATTTTTTAATTTTTTTAAATTAAACAAAAAATCAAAAATATCCGAAAAAACCGAAAAATTATTGAAATCATTTTCAGGCTTTGGAAGTTCAAAAACCATATTGAAATTTCGGATAAATAAAAATATTTTTTTGTCCATTTTCGATCAAAGTCAAAGACTTCCAGTTTTTGGAGCCTAAAAATAATCAAATACTGAGCAATATCTTTTTAGATTGAAAATGAACGACAAAAAAGTTTCAGCTTGTTTTTTGGACTTTAAAGCCTAAAAATTTTTTCACTTTTTTAGCGAACAAAATGTTTTTAATCGAACAAATAGAAGACATTTCAAATTTCAACATTCGTATATTTGGACTTTAAAGCCTACGAAGAAATAGAAATTAACTTTTAGCAGTTTTTCTACCTTTAAAAGTTCTGTAGACCCGATTTTTTAAATAAAATCTAAATTTGGGCAAAAAGCGGGTTGAAAAATTCAAAAAATTTAATAACTAACAAAAATATTTTTTCATGTCCGAATTCGTTTCTTCCAGTATTGTGGAGCATAAAAATAATCGACTTTTCAGCACAAAAAAAAAATTTGTAAACAGAAACATCAATTTTTTCAGCATCTTTTCCGAACCTTAAGGCCTAAATATATTCAATTCATTTTTAGCTAAAAATGTCTTTTAAATCGGAATCGAAAAAATTTCAATTTTTATTTACAGTAAAAAATTCGGAATTTTTTTCCAATTGTTATGTGATTTTTGAGATAAAATCATGAAAAACCAACTGGAAATCCGGTTTTTCGAGTTTTTTTTCAAAAAAATTGACAATTTTCCCGAATTTTTTCACGCTATTTTTGGTAATTTTTTCTCCAAGAATATCGAATTTTTTCAGTCTTTAGCTTTAAAAGTACTGCAAAAAACTACTTTTTCTGGAAAAAACCTATAAATTCAATATTTTGCTTTTTTAGCTTTTTCCTTTTTTTGTGAAAATTTAAGAAATTAACTTTTCGCCACTTTTGTACCCTTAAAAGTGCAGTAAACCCGATTTTTTTGCTGAAAAACTTACAAAAACAGGAATTTCGGTTGAAATTAAAATTAGGACAAAATAAAAATATTTTTTTGTCCGAATTTTTCCAAAATTTCAGTTTTTGGACCCTAAAAATATTGATCAATTCTTTAGCGAAAATTGTTTTTATTTTTCAAAAACATGCTACGACTACACCACAACTCTGTCAAAAAACCAATGCTAATTAAATTAGAGAAATTCTTCAAAAAATCCCCAAATTTCCAGGTTTGCAAAATCTCGTGCGCCGGCGGAATCACATACAACAGAGCATCTGGAAGGTCAACGGCACAAGAAAAAGAAGCTATGGCAAAACAGGGCATACCGAGCACTTGCACACCCTCGCTAAAAGATTGTCCTATCGTTGTGACCTATGTGACGTCACTTGCACCGGTCGTCTAAGGGCACGTATTCGACGCTCACGCTCATGGCGGAAAACACTTGAAAACTGCACAATTGCACAAAAAAATGGGAAAACCGTCCGCCTGAAGTCGACGTTCCGACGATTATTGCCGGGAGCCGATGGGCTGACGTAGACGTTTAAAGCCAAAGCGAAATGGCATAAACAAGCTCTGCCGGAAAATGTGCGGCATTTGAAAAAATAATAAAATGTTGGAAAAAAACGAGAAAATGCACATTTTTAGGCTCAACAAACTGAAAATATAACGCAAAAAAATTTAGAAAAGGATTCTTAGGAAAAAATTAGCGTTTTCTCGCCAAAAATGCTCACTTTTCGATAAAAATGTACATTTTATTTTTTAACTTGAATTTTTAAAAATATTTTAGGGCTCAAAAATGTCGTCTGTAAATTTTGCAAAAAAAATTCTAAATAGTGATTTTGAAATTTTGAGATTAACCTTCGCCAAAAAAAAATTTGAATTTGACAACTTAAAATGCTCATTTTTCGAGGAAAATGTAAAAAATTTTTTTTCATCTGAAATCTGTAATTTAAAAAATCATTGATTTTTTAAAAAATTTCTACTGTAAAATTTTGAAAAACGGTTGAACGACGTCAAAAAGAAGGACGTAAAAATCCGAAAAAAAGCAACAAAGAACTAGGAATTTTAAAATGTCCAAAAATGGTCTGAAATTTTGAGAAATCAAAAAGAACAAGTTTCTTTCCGTTTTTTTTTAAGCAAAAAATCGTATTTCTAGTCAGAATTTAAATTTAAAGCATATTTTAAACTTTTAAACGCAAAAACATTATCTTTTTCTTTAAAAAAAGACAATTTAAACGATAGCATTTATTAGCTTTTTTCTCAACATTGCCTGATAACACATTACATAATGAAACTTCTTGAAAAAAAAAAGCTCTCAAAAAAACAAGTTATGATTGCTCAAAAAATGGCCTCAAATTAGCTGAAAGTTAAAATTTGACCGACGTGTCAAATAGTGCGGCTGGAAACTATCTTTCTTTTTTGAGATCACCGTCAAATTTTGAGTATAAAATGTAATTATCTTGCGTTATCACCTTTGTTGATTTAGGTATAACTAAGTCGATGGACGGCGAGACTTTTAAAGGTGGAATACCGATTAAGACTTTGCTTTTTTAAACCATTTGGGATGACTTATCGGTGCGATACTGCAAGCCAAAGGTTGAGATAGCTAAAAATATATGGATACGCCGTTTTTTCCATCAGATAAACTTTGATCGGCCATAACTTTTTTATTGGAAAATTTTCAGAACGTCTCATTACGAAATTCGGCAGTTTTGTGGCCATTTTGGGCCTAAAAAAGCAAAGTCTTAAATTTCGGTACTCCACCTTTAAAAATCTCTCCGTCCATCCCTTAAAATACCTAAATCAAGTTGATAACGCAAGATTACATACTCAAAAATTTGACTGTGATTTCAAAAAGAGTAAAAAAAGTTAGCCTCTTGGCAAGCCGTTGAAATTTCAAAATTCCGCTAATTTGAGTGCCAACACTTTTTTGAGATCATAACTTGTTTTTTTGAGAACTTTTTTTTTCAAGAAGTTTCATTATGAAATCGGTGTTTTCCGACAATTTTAAGCAATAAAGCAATAAAAAATTAGAATATACCACTTGATAAAAATTAAAGATTTTAAGTTTAAAATAAAAAAATATGTTTCTTTCCGATTTTTTGATAGTTGAGCTAAAAGTTTTGGCGGGAAATTCAAATTTTCTATGTTAGAAAAAAAATTGCGGTGAAAACTCATGTGAACAGCACAGAACGGCTGCTTATGAGTATAGGTGTGAAAGTGTCTCATTTCGATGGTTTGATTTACTAAAAAAGCGGGTAATTCCCACAAATGACGTCAAGATGCTCTTTATTATTAAATTTAATTAAAAGAGAGCATGGTGAGGCGTAACTTTTGGGGAAAAATTCCCGAACTTTTTTTTGTAGTTCAAGCCGAAATGAGACACTTTGACACCACCACTTTCAGACAAAGTCCCCCACTTATTTGGTAAAACTAGTTCAAAACCCGACTGTAGTACATTTTTGGCAGAAATTTGAAAATTTCAACTTAACACCGCTCAATTTTTCCAAAATTTCACAGTATCATTTCAATTATGGTTTTGCTTTTTTAATTGAAAGATATATTTACAAAAATAGAGGACCATTTTTAGTAACAATTTTTTGGCGCTCTCAAATTACACCTTTAGTCAGAAAATTGCAATTTTCTCCAAACAAGTGATTTACAGATTTATTTTACCTAAAATTAACAAAAGATCGAAAATATTAGACTCCCGCTTTTTTTTTATTTCAATTTTTCCAATTAAAACACAAACATTGAGCATTTCTAGTTGGCACATACCAAATTTATAGGCGAAAAATTTGATTTCAAAATGTCAAAATTCAGAATTTTTTTTTGCTAAATGTTCAGCACCGATTTGTGCGCAAAAATATTTGAAAAAAAAAAAAACTCGAAAATTGAGCATTTTCAGTTGTAAAAGTCAACTTTTAGGCGGAACAAATGTGCAATTTTTCCCCAAAAAATCCAAATTTTCCATTTTCTATCAAATAAAGCACTGAAAAAATTTGTTATACCTAATGTGGAAAAAGTGAATTAAATCAGATTTTTTGAAAAAATGCACTTTTTTTTTTGCCAAAAATAGTTCCCCGACTTTTTGTTCCAGAGTTTCCTCACCAGGTCATCGGTATCATCGGATAAATAAATTTTGCGGGAATAATTGCGCTTTTTTTGTATATCAAACCGAAATGAGACACTTTTACACCCCACTTCAGGCAAACGACTTTTTTCCAGAGTCATCGGCATCAACACGGTAAACTTCGTCGGCGGTAGGAAGCACTCCACCGGACAACTCGAGGGGAAGAAATACAGCGCGATCCAGTTGCTGCCGCCCTGAGCTCACTCGGTGCCTAAGGAAAACCGTGGTGCTGCTGCAACGACGACGATTGAACGGTGGAAGACGAGAAGCTCCGAGCAATGATCTCAGGAGGTACAACCTGTCGCCGATGTACATGTCACTGAAACCGTGATGCTACCGGAAAACTGGTGCAATTTCCATAAACCGTGCGATTGCAAGTTTTCCGATCCGAATGCCAAGGACATTCATATCAGGTGAGTCGTCATCGTGTAAGCTATCGCAGAAGATTGATCCGACGTTTGGTGTGAAGCCACCGAACAAAAGAACACAGGAGAAGCGGAAGAATCAGCTTCCAGCAGTTCATGGATTGTGTAGATTTTATTTACACTAAATCAACAACAACACAAAAAACATGTTCCAACAAAATTGGAAAAAAAAATTTTAAAAATCCCAAATTTCCAGGTGTCTAAAACCCATCCCGTGCATACAATTTTTAGGGTTAAAATTGGAAAAAATCATCAATTTTTCGGATAAAAATGAAACACAATCTGATTTTTATAGAAAAAATAATAATTTGTTGGCAAAGAACTACTTTCAGGCTTTGGAAGTTCAAACTTTGTAGCAACATAATTCAGAAAAAATCGAAAGATTGGAAGAAAAACATTTTTAATTTGAAATAAAATTCAAAAAAATTTAAATTTTTTTAAAAATTGAATTTTTGAGTAAAGAATTTTTTGCTATAAAATTTCAATATTTTTCAGGCTTTCAAGTCCAAAAACCGTCCGTTGAAAATTCCGAAAAAATCGAAAATTGGAAAAAAAATTTTAATTTAAAGGTGGACTACTTGCTCTGTGGGGGGAAATTGCTTAAAACAATGCCTATGGAACCACAATGCCCGAATAGCATAATAAAAAAATTTTAAAATATACTCTAGATTTTATATTATTTTTTGAGAATTGGAAAAATCACAGTTTTTGCCTAATTCCTTTATGAATTACCGCCAATTGGTTCAGACTGGAGCGCGCTTGCATGTTTTTAAATTTATTTATTTTATTTATTCTTATTTTCCACCCATTTTTAATGTTTTCGATGTATTTTTATTTGAATTTTAGCAGAAAAAGTCAAAATAAATACTAATATTAAAATGCACGCTTACAGGCGTAAATCAGTGAACGATAATAATTAACTCAGGTTCGAAATCGTTCAAAATCGTTTCTTTTTCATTTTTACCTGTAAGCGTAGCTTTGCCTTTAGTCGAAAATTTGCATTTATTTTCACTTTTTCTTTAAAATTCAAGCAAAAATACACCGACAGCATGAAAAATCGGTGCAAAATAACAAGAAATAAAATAAATAAATTTAAAAACGCACTGCAAGCGCGCTCCATCGAACAAATCCAATTGGCGGAAATTTAATGGATGGGAATTAAGCAAAAACTGAGATTTTTTTTTTTCAAAAAATCATATAATATCAAAATTTTTGTTTTTTTTTTAATTTTTTTAAACATGACATTCGATCATTGTGACCCCATAGGCATAAAGGTGGTGTAGTCGAATTTTTTCTATTTCTTTACTAGACTCAAAATTGTCTGAACGCCGAATTTCATTAAGAAACTTCTTGGAAAATTTTCAAAAAAAAGTTATGGCGGCTCGATGGCCTATAATTAGTGAAAATTTGAAATTTGACCAACTTATCATTGTCGCATCGACTGGAAACAATTTTTTTTTTGAAATTGTCGTTCAATTTTGGGTGTACAGATCGATATCTTGCGTTTTCAGCTTTCTCAAGGTATTTGTCGATGGACTTCAATTGGATCTGTCAAATTTTTTACCAAATCTCGTCCATCGACTTAATACCTAAAAGCTGAAAACGCAAGATAATCGACCTGTATACCCAAAATTGAACGACAATTCCAGAAAAAAATTGTTTCCAGCCGCCGCGACAATGATAAGTTGGCCAAATTTCAAATTTTCACTAATTTTAGCCCATTTTCCGAGCCGCCTTAACTTTTTTTTTTGGAAAAGTTTTCAAGAAGTTTGATTATGAAATGTCTTCAGTGTTTTCAGACAATTTTGAGGCCAGTCTAATTAAGCAATAAAAAAAATTCCTGACTACACCACCTTTAAAGCAATTTCCCCACTGGGCGCGACTCAACCTTTAAAGGGGGATTAGAGTTTGTGGGTATTTTGCTTAATCCATAGACTAAAAGTGCATTCCAAAAACACCGAAGTGATTTCATAATGAGACTTCACAAAAAATCTCCAAAAATTTTTTATGGCCGGTCAAAATTCGAAAAAAAAAGATTGCGCAACTTTCGCGAAATTTGATATTTCGCACACTTTTCTTTGTCTAGCAGCCGATGGATTTTAGTTTTTCTAAGAATATCACCCTCTATTCCTTCTTGGTAATTTATCTCGCGAAACGAATCCGTTGATTGAGACAACTTTTAGGCCGATAGGCATCCAAAAATGCTCAATATAGGGATGCCTAACGGCCTAGTTGTGTCAATCAACGAATTTTCGCGAGATAAATCATTAAAATAAGGATTAAAGGGTGATAATTTCAGAAAAACGAAAATCCAGCTGCTGTGACAAAGAAAACTATGACCCGAAATTTCAGATTTTAGCGTTGCATCTTTTTTTTCGAAATTTTTTATTTTGACCGGCCATAAAAGAATTGTTGGAGATTTTTTGTGAAGTCTCATTATCAAAATATTCGGTGGTTTTGAACCAGTTTTAGTGTATTTAAGCAAGAATACCCACAAACTCTACTCCGCCTGATGATTAAAGGAATGAAAATAATTCTTGGAACGTTTGGTTTAATTTTTTGTTAAAAAATCCACACCGAAGAAAAGTCCACAGTATCAGAGCCTCCGAGCTTCATGAAAAGCCGTGGTTCGCCCCACCGTGGCTCCAGAAGGCCGGGAATTCAAAATAGTAGATGATAGAACTATTAACGAAAAGTACTCGCCGGGCTTAATCCGGGCGTAGAGTTCATTTATGAGGATCGACATCCTTATGTCTGATATCAATCTCTGGGAGGAATGTGTAGGATAATATCGCAGCGAGACGTTCGGACCCTGAAGACGTGGTGGAGCGTCCCACCACCACCTACCACAACGGACGCCGCAGACAGTGTTGGGATGCTCGAGAGTTGGAATTATTGCGAACGTTCATCAAATGACAGGGGATCGGTGTGCGGATGTGGTTCTGACGTGTACGCCGGTGCCGACTTCGGGTTGAGCAGGATTATTTAGGCGGTTGTTAGGAGAGTCGACGGCACGGGCCGGGCTTTTTTTTTTGCCGGAAAGTTCGGGATTTACCGGTTTGGGAACGTTTTTTTTTGCGGCAAATTGCCGGTTTTCGCCGGAAATGTGAAAAACGGCGCAAACCTGACAGTCTAGCGGGAAATTTTCAGTTTCGGCAAACTACCGCGATTTGCCCAAGGATCACAATCGTCCGGCAAATTCGGTAAGTTGCCGGTTTGCCCATTAGCCGGTTAGTTGAATTTAGCAGAGGAAATACGGCAAACGGCAAGTTGCCGGTTTCCCACGACTTACCGGAAATTTGAAAAACGGCAATTCGCCGGTTTGCCGGAAATGTGAAAAACGGCAAATTTCAGAATTCGGCAAGGCCGGTTTTTGCCGGAAATTTTCATCTTAGGAAAATTGCCGGTTTTTGCCTGAAATTTTCGTTTCAGTCAGGGAAAATTGCCGGTTTGCGGGTTTGTCGAATTATCCGGAAATGTGGAAAACGGCAAGTTCCCGGTTGGCTGATTTGCCGGAACTTTTTAATTTTCGGTAATTTGACCGATTAGCCGGAAATTTTTTAACGGGATTTTTGATAAGATGGATTTTTTTCCGGCAAATTCGGCAACTCCGGTATGCCGGAATTTTCATTTTTGACAAATTGCTCCATTCGCCGAACAATAATTATGCCAGAAATTTGAAAAACGACAAGTCGCCGTTTGCCGATTTGCCGAAATTTCAAATAACCGGCTATAATTTGCAGATTGCCGGAAAACTTTTACATATTCGGCTAAGTTACCGCTTTGTCGGATTTTTTAAACCGTTTTTTTCAAGATAGATTTTTTTTCCGGCAAATTTCCGGCAAGTTTCCGCATCGGTTTGCCGGAAATTTCAGAACCGGCAATTTTACATTCTGCGGATTTCTTGTTTGACAATCTCAATTATTAAGACATATCGAACAATTGAGCCGGATCCCGAGCCGCCATCAAGCCTTATTCGCCACAGCTAACTACTTTCCCAAAATGTCGTATTAATCACTTCATCTGGAGACAAGACGAAGCTAGTATTGTATCGGATGTCCTGCTGATAAGGATTTGCGCATTTATGCGCTCGCTTCTATTCGGAATACAAAGTGGTATGATGTGGGGGAGTTTTTTTAATTGTTCCTATACACATATTTTAAATTACTTTATCATTGGAAAATCTAAATTATAGCCCAGTTTACAAAAAAATCTATATTCCAAAAAAAAAATTGAACAAAATCGATAATATTCCCAAAAAACGTTTACATAATCGAACTTTTTAAAACACTTTGAATAAATCGATAAGTTTACAACTGCTGACAATTAAAAAAAATCGAAAATTTCTCAAAGCTCCAGTTGAAAAAATTAATATTTTTCCCGAAAAAATTGAAAAAAATGGATAATTTCCAAGGAACATAAAAGCTAAAGATTTTTTAAAAAAATCGAAAACAATTCAAACCTTTCGGTTCACAAAAATTTGAAAAAAATCGTGATTTTTTTAACTTTTTTTCATCAAAAATTTGTCAAGAATTTGGAAAAAATAGAAAAAATCAATATTTTTCCGAAAAAATTTGAAAAAAAAATCGATAATTTCAAATAATAGTTGCAATTTATAATTTAACAGCGTAGACAAATTTTCAAAGATGTTTAAAATTTTTCACGTTTTTCTCTCTGGTTTTTTTAAAAAGCGTAATTTTTACCGAATTTCTCATCAAATTACATGAATTTTTCTGAAAGAGCGAGAGAATTAAAATAATTCGAAAAACTCGAAACAATTTGTTACCAGATCTAGCCGAAAAATCCCACAGAAACCACCAAACTTTACTTTTTTTATTTAATAAAAAAAAGTTTTAAAAAATATCAATCTCCCTTTTTTTCTGCCAAAAGCGACTTTGATGTGGGTAAGCTTGAAAAGTTTAAAAATTTGCAGGAAAAAATCAGGAAAACTCTTTGTATTTTCAGAGTCACTGCCAATACTCTCGTGCCTATCAGTTAATCGAATGCTCCGAGATTTGCGAAATAAATATCCTGAAGTTGCGTGTCTTGATGATTATGTAAGTTTGAGAGTTTGGAAAAATATTCGAAATTTTTTGGGAAAAATTTGGTAAAAGTTCACAAATGTACTGTACAATTCATTAATTTTTTTGCGAAAAAATTTTTTAAAATTCTCTATATTTTTGCTAAATAGTTTACAAATCTAAATAGTATGAAAAAATATTTTAGCAGAATCAACAAAAATTGTATAAATTCATAATTTTTTGAAAATGAAATAAATGTTTTTTTGCGAACCACTAAGACCAAACTTAAATATGCTAAATAGGTTTTTTTAATGCAGGATATAGTTTTTTAGCTGAAAACGTCTAATGAGAAAAAACGGATAACATTGAAAATTTACGTACATTTTTGCAGACCTTTTTTGCTCACAATTTTGTAAAAACTTTCGGCAAAAATATCACCTTAGTCAAAAAAAAATTGCTTAAAAAAAATTTCTATAATACAAAAAAAATGTGAAATCTATCTATTTTTTTCAAAAAATGAGCTACCTAAAAATCTATTAATGATTCTGTGCGATTTTTTTGTGAAAAATTTTGAAAAAATTCAGAATAATGTATAATTCCGTTATATAATATTTGGCGAAAAAAATTAATTTTTGAACTATAATTTTTTTTATGAAAACTAGTTTCAAAAATCGATATTTCACCTAAAACGAACAACCCTAAAAATAGGCGGCACACGAACTATGTTTCCGGCAAAGTGGTAATTGCCGAAATTTTTGGCAAACTGTATAGGCTTTGCAGAATTTTTTTGTTGGAAATTTCAGATTTTCAAATTTAATCGGCAATGAAAACGAAACGTTTATTCCGCACATCGGCAAACCAGCAAATTGCCGAATATAATATTATGTCTCCTAATAAGTTCCGGGGCAAAAATCATAACCTTGTTCGCTGTGTATCGATTTTTATGAAACTTTGGGAGTTTATGTTATCAACCGTGATCTTTCAATTGACAATATTCACACAGTTTTGTGACCACCCCAAGTGCCCGTACTCGGAGCCAATTGTTTCAGGTATTTTTCTGATCTCGCTTCTTTTTATCTTTGAATCGAGGTTTGTTGCGGATTTTGCTTTGTTTCGAATACATCGTTAGAAAACGAGAAAAGTTTGGAAAAAAATTTGTCCAATAAATTTTTTTTGGATGATCGGCAAAGAAGTTTCAAAAAGATTTTTGTCGAAAATTCTCTTTCATACAATGTAAATGAGGTGTCCGAACCAAGTGTAAATTATTTTTATACATACGAACAACATATCAATTTAGTTCGATACACTAAAATGATAATAATATAATTTTTTCGGATAATTTTTGAGTTTTTTGAATACTTCTTAAGTTTCAAATCGATGTTCAAACTAAAAGAATTTTTGTGTGTAAAAATAATTTTCACTTGGTTACATCATTTTTGTATCAAAAATCTGTGAGCATTTTAAAAATCTTTTTGAAGCTTTTTTGAAACCAAAAAAAATTTTTGGACGGATTTTTTTCCAAACTTTTCTTGTTTTCTAGTGATGTATTCTAAACAAAGCAAAATCCGCACACAAACCGATCAATATCTTCAAAGATAAAAAGAAGCGAGATCAGAAAACCTGCCCAACAAATTGGCTCCGAGTACGTTGGGGTGGTCAAAACATTTTGTGACTATTTTCAAAACACTGAAAGATCATGGTTGAAAACATAGATTCCCAATTTCATAAAAATCGATTTGCAGCGAAGTTAGGATTTCTTGACCCGGAAACTTATTTGGAGACCTTATACAATTTTTCAACATTTTCCAGTAAATTAGGGAGGTAATCGTCTCGAACATTATCGATTCATCTCCAATGTCACTTTATCCGATGCGTTTAAGCGAATTGTCGAAGCTTCACTTGCAATATGTGTATTCTGGTAGGGGGGTTAACTTTTTTTTTCCGGAAATATATTGAAAAATGAGCATATAAAAAGTTTTAAAATAATTTAAATATTTACAAAAAAATTTTTTCTGAAGTCAATTATATTGCGTTTGGAAAATTGATTCTTGTTTCGAGAACGGAAACTCTTTTTTTTTAATTAAAATGTTGAAAAAAAATCCAGGAAAAATGCTGAATTTTTCGGGATTTTTCTGAGCACATTTCTAGCCAAGCTCTAAAAATGAAAAACTTGAATTTTTCTTTATTTGAATTTTGCCCAAAAATGACTATTTGAGGAAAAAAAAAACATATTTCAATCACCGAAAAAATGTATTAATTTAATATTTTAATGTTAAAAAGGTATTTGAATTTTTTTTATACGACCTTTTTTTTGCACAAAAAGTTGAAATTTGGTTGAACCCGGATAAAATTTAGAAAAATTAAAATTTCAATTTTTTTTTGCGTTAAAAGTTTTTTAAGGTTAAATATGTTAAATAAGCACATTTCTTGAAAAGTTCTTTTGATTTTTTATATTAAAAAGTCTATTTTTCAAAAAAAAATTTATTTTAATTTTAAAATTTTAAAAACTTTAGAGTGGTGTAGTCGATTTTTTAAATTGTTCGATTAGACTCAGAATTGACTGAAAACACCGAATTTCATAATGAATCTTCTTGAATACTTCGCAAAAAAAAGATATGACTGCTAAAAAATGGCCTAAAGTTAGTTAAAATTTGAAATTTGATCGACTTGTCAAGCGGCTGGAAACTATTCTTTTTTTTGAAACCGTCAGATTTTGAGTATAAAATGTAATTATATTGGCGATATCAACTTTTTAGGTATTTTAAAGTCGATGGACGGAGAGAAGACATTTTTAAAGGTGGAGTACCGATATTTAATACTTTGCTTTTTTAGACCCAAAATGGCCCAAAACTACCGAATCTGCCGTAATGAGCAACGTTCTGAAAATTTTCCACCAAAAAAAAGTTATGGCCGATCAAAGTGCTTCTTTGGAAAAAACGCCATTTTTAGCTAAGATGTCAAACTTTGGCAAATTTGACAGTCTCGCACCGATAAGTTCGGCCAAAATTTCGGTCTAAAAAAGCAAAGTCTTATATTTCGGTATTCCACCTTTAAAAGTATCGCCGTCCACCGACTTTAAAATACCTAAATCAAGTTGACGCAAGATGCCAATTACATTTTATACTCAAAATTTGACGGTGATTTCAAAAAAGAAAGCTAGTTCCAGCGGCTTGACAACCAAGGTCGGTCAAATTTCAATTTCCGCTAATTATGAGGCCTTTGTCTTATTGGAGCAATCATAACTAGTTTTTTTGAGTGGTAACTTTTTTTTTTCGAGAAGTTATTGTCATGAAATTCGGTGTTTTCAGAAAATTTTGAGCTAATAAAGCAATCAAAAAATATTCGACTAACTTTTTGGCCTATTTTTTTGGGCTAAAATTGAAAGGTATTTTTCCAGCAAAAGCGGTCCGTGTCAGACGTCTGTCCGAACGTTCTCGATGCTTTAACCGACGAGCAGAAGCATTCGTTGACCGCCCTGGCACAGAATTTTGTTCTGCAAATTGCATTAAATCATATACACGAGGTATGCGGGGATTTGAGCAGAAAAAATGTTTAGTCAATTAAGAAAAAACCTTGAGTTTTTAAAAAAATCTGTGGATGAGAAATTTTCGCAATAAAAAAATTATATCGGTATAAAATTAATTTCAAATTTGAAAAAATTTCAATCAAATAAATTTTGAATTTGCATTCCAACGTCATCGGTCTAAAGAAAAAATTGCTTGAAAAATTGAATTAAATATATTTCTTTAACTACCTGTAAATTTTTTATTTGGGATCCGAGAATTCGACACTGAAATTTCATTTAAAAAAAATTAAATAAAATTTGAAATTTTTTGGAATATTGCAAAAAATTGCTAAAAATTGAATTTTCCTATATTTCGATCGGTTTTTTTTTAGATTTTTTAAAAAATTTTTTTTTCAGCCATTTCGGGTGGCCGAAAATGGAGAAAAAATAGTCAGAAAATTCAAAAAATTGCTTTTTTTTTTCAATTTTCCGAAATTTTGTATCTTGATCGTCCAAAAATTTAAAAAATAATCGCTAAAAAGTTTAAAAAAAAATTATTGAAAACAATTTTTTTAGCCAAATAATTTCTAGTAGATTGCATGAAAAAAGGCCCTAGTGAAATACGAAACAATTTTTTTTTCAAATCCGATTCAGAAAAAATTGAATTCTCTCTGATTTTGGGCCGATATTTATAAGATTTACAATATTCCAAAAATTCTTGAGAAAAATTGAACTATGTCTGCCGTATTCCTGTGAACATAGCGGAAAATTGAATTTTCCAGGTTATGTTTATCGGAAAAAGTATAGTGACTCTACGTAGAATTCATGAAAAATTCTGACAAAAAACCAAACATTTTGGCCCAAAATCAGAGATTTCACAAAAAAAAATGCTGAAAAATCAATTTTCAGCAATTTTTTTTTCAAATTTTTTTAAAAAATATATTTTAGTTAATTTAATAATTTTTTTTTCCGTTTTTTTAATAGAAGAAAAGTTATTTTCCCAAAAATGTGCAGACATTTCAGAATTTTCGGAAATTAAAAAAATTTATTTAGCAAAAAAAAAAATTTTTTAATCCAATTTTATACTATGATTTTTTCACTTTTTCGGTGGTATTAGGACTGAATTCAAAGTCTCTTCGAAAAACATAAATTTTCAGAAAACTTAAAATTAATCTGATTATAATTCGGAGCATATATGAAATGTGCTTTTATCACAACATTTTTTTTTTTGACAAGTCAAATCTTTCCACATTTTTAAAAGTTCCTATTTTGTATATATTCGGATTTAAATTATTTTTTTAACGGGTTTATTGTCTGAGCAAAAAAATTGAATTTTTCTAAAATCACCAATTTTCTTCCAGATTCTCGGAATCGATCGTCTTCAAGACCCACTATTGATCTACCATAGGATGCTCCGATCAAAGACCACTGGAGAGCAATGAAAAATGCTGAAAACGCAGAAAATCTCGACGATTCGCCAGTTTCCAAAAAGGAGAAGGATACTCGACGAGGAGCCCGCCGATATTTGAGGATTTTTATTTTAAATTTGGTCGGTTTACGAAATTATTTAATTTTCCTCTATTCTCCCTCATCTCTGTGTTTTTTTCTAATGTCTTTGGGCGTAGAAAAAACGAATGGCTCTCTTCGCGGTTAAACCTTGAAATTTTTATTTTTCTACTATTACCTCCCCCTGCAAACGCGCTCTATTGGCGACAATTCGCAATGGAGCGATTGCATATTTTGTTACCATTTTCCAGACATACTCATGTTCGATCTTCCACTAGGGGAGGGTCTCGCGATTTTTTGAAAACTAAATTTAGATTTTTTTTTGAAAAATATTCGAAACAATTTTAGGTTTTTCGAAAAATCCTAATTTAGCCTAAAAAATCAAAAATTGATGGGATTTTTAAAAAAAATTCAAAACTTATAATCAAAAAAAATTGCAAAGATGTTTAATTTTTTTGTTGAAGAAAATTTTTTGTAAAAATTAATTGATTTTCCGCTTTGAAATAGTTTGAATTTAGAATTTTTTGAAAAATTATAAAAATTTTGAATTGAGCTTTTGAAAAAACATTACTCAAAATTGTTGGAAAAATTTTGAATTTTTTTGAATGAATTCAGAACTTTTTGAAAACGGAAATTCGAATTTTTCTGAAAAAAACGTTCGCAAAATTTTTCGAAATAATTGAATATTGAAAAAATTATAAGTAAATTCCTAATTTAGTCGGAAAAAAATATTGAAAATAAAGTGACGATTTTTGAAAAATTTTCCCAAAAATTCTATAGAACTGTCCTGAATTTCTATAAAAAATTCGAAAAAATAAAGTTTTTTAGAAATTTGCAAATTTCTTTAACATATTGGAAAAAATTCTATTTATTTTTGAAAAGTCATTTCTAAAATCTTCCTTTCTGCTAAAACCTGCAAATAAAAGGACCCTGCCCCTAACTATCTTGTTCATCCAAAAACCGACAATTCTTCTGTTTTTGTGTTATAATCGTCCTTTTTGACTTGTCAAACAAAAATTAAAATAAATTAGAAGAAAAGGGTTTAGATACGATTTTGCCAGCACGAGGCCGAGGTTTTTCACGGCCACGTGGCACAGGCCGGCAAGTAAGGCTGAGGCTGTGGGGGGAAATTGATAGGGAAGAAGGCAGGAAAAAAAAAAGAAAAATTCAATATTTTAAAGCCAAAATAAATTTTTCTGAAAAGACTAGCAAAACAGGAATGGTTAGGGGTAAAGCCGATGTCGGAGTTTGACGGAGAATTTTGCAAAAACATTAACAAAAACGAATCGGTAGGGACGGACCGGCAAGATTGATTGTTGAAAATTGACGAAATCTATCGATTTTTTGGCGCACGGGGTTCTGGCCTTCCCTCATAAATGGAAGAGTTTTGCCGAACTGGGCCACCAGGTCATAACTGGGGTAGGTTTACGGCGCGTTGCGTGTCGCGTCGAGGCTCAATTTTAGTTGTAAAACTAAAGAAGATGTATTTGTCCGTGTGAAGTACACGACTTTCCCGGGGCGCGATTGTCATGGAGCGCGAAAAATTAAGGGCCAGACACAGAACCCCGTGAAAAAAGATAATCCCGTTTAGAATCGGTGAGGGCGTGGAAAGAAAAGATGATCAAGAAAACGGGAATGAGCAACATTTCCAAAAAATCAACAATAGCGCAATTCCAGAAAATTCCATAGAAAACGGGGTCTAAAGCACCAGATTAGTGTTGTGCGTGGGCGTCCACTGTGACGTCATCACCGTCCACGTTTCGTAGTTCTACCGACTCGTGCTGATCTGAGAGCTCGGCCGAGACTTGGAGATCTCGGTGAATGTGGCGAATGCTTCGCGGGTGAACATGTCTGGAAAATCAGCAAGTCAGGAGAAAATTCAATTTTGCGCGTCAACTTTGATGTTTTGTTTGTGTTAGTGAACTTCAGAAAATTGAATTCGCCAAATTTTACGAGCAAAAAATTGGATTCTTTTGGTATTTTTCATGGAAATTTAACCAGGTTAAAAATCGAGGTTTCTCCGGAAATTTAACGTACTTTATCGATTTTTCATCAGAAATCAGTAGAAAATTCCTTCTGCGCGTCAATTGATGTAACCTTCGGGCCGTGCGGAACTGAACTGGATTTCGCCTAATACGAGCAAAAGGGGGGCTACCGTTTGCAAATTTTTCTTGGAAACTGTCAAATATTGAATTTTTCGTGAAGGGCAAAATTTAACCAAAAATCGGGCTTGCTACGGGATTTAACAAATTTTATCGAATTTTTTTGCGCGTCAAATTTGATGTTTTTTGTTGAACTTCGGAAAACTGTATTCGCCAAATCTTACGAGCACAATTGGACTTTTTGGGTATTTTTAGTCCGAAATTGATTGTCTTAGAGATTAAACGCGATTTATCCATTTTTTATCGGGAACAGTAGCAAAATTCAGTTTTGCGCGTCAAATTTGATGATGTTTTTTGTGTTGGTGAACCTCAAAAAACCGTATTCGCCAAATCTTGCGAGCAAAATTGTATTTTTTGCGTCTTTTTCGTGGATTACAAAAATCGTGCATATCTTTTAAAAAAAAAATTCCACACAAAAGTACATTTTCACACAAAAACTGCAATTTGCGCGTAAAATATGGCGCAACCATCGGTTGAGTGCGGCACGCCGACTCAAAAACACCATATTTTTCACGCGCATATATTAATTGAAGCGCCTTCACGTGGTGTCAGGATGGGTCCACGGTTTGATCTACAAAAAAATGGGGGAATTTTTTGCCCAATAATATAGGTGACGTGCATGTTCTTAGCCATGCAGAATCAGTCTAAAATCCCGCCTTTTTTGTAGAAACGTAGATCAAGCCGAAATGAGACGACTCTGGGCTTTAAAACACTCACCAATAAAACCGAGACATGATCGGAACGTTACACGTGCACTTCCGATCGAATATCTCCATCGTCACACCGGCAGCCCTTTCTCTTTTTCTTCTCGAGTCTGGAAAATAATGATTTTAATTTTATTCTTGGAATTTTAAATTTCAAACAGTAAAAAACCAAAAATTATAGCAGTATTAACTTATCCAAGTTAAAGAACTACAGTGAAACTACAGAAATATTAATAAATATTTCGATGCACCAAGAGCCGAAATCTCTGAGAGCCCAAATCTCGGCTCATTTCGAGTTACATTACAAATAAACTGCAAGCTATATATAGAAAATTCAATTTCAATTATTTTGTTAGTTAACAGAATTTGGCTAGAATTGAAATCGAGCTGGGATATGGGCTGGCTAAGTGAATTTTTCCTTTTTTTTTTTGTTTATTTTGATATCCAGGGGTGAGCAGCAAACGATGTTTCCGGCAGATCGGTCGCTAGCTTGCCGGAATAGAACACTGCAAATCGGCAAACCGGCAAATTACCAGACGAGTTTGCCGGCAACGTATGCTCCCTATGAGCCACCCATCAATCGATTTTGTCGGCTTATATTTACGCCATATGGCGGTTTCAGAAGTTTTTATTTTCATGAAAACCAGAGTAACTATAGATCATTGAAAGAATATTTTGTCGTTTATTTTGAAAATATGATAAAAGACAACCGAGATATAAACGGTCAAAGACTAGTCAAGGGGGGCCATACAAAAATGTTTTTTTGTAAATTTAGAAGAAAATGTGTTTCCGTCTTATTAAAAAAATCTCTCTAAGCATTTCCGGCAAACCGGCAATTGCCGCCCTCCCCCGACCTACGCACCTGTTCAAAGTACTCCTCAACAATCCGATGCGCAAACCCCATCGCTCAGACACAATCCCTCTCTCGCCGGATTGGAGATGTCGGGGCGCACTTGACAAGCATACTGCTCATATCGGAAGTGAATTCGTGTCACGTTGCTCCTCCGGCACATCTGTCACATGCATCTTGTTGAACTTGGCGAGGTACTCAAAGTGTCGACTGAGGTCCGTAGCCAACACCATCTCCACCATCGCATATCGCATTTGTATGACTCGCGCGACAGACTCGGGAAGATGTTCACGTTGGCGTTGTGCTGAAGGGTGCTTAGCTGAATGGTTAGCCTAGTGCGGATAATTCCAGGAGTTATCATTGTAAAGTATTGCAAGCTGTCGCGTCGTATTGATCAGGTACGCGTTTCCTCTTCCAGGATGGGCTAGATCATGCACCGCCTCTGCGAAAAGAACCGCCGTCACCGCATGACTTTCATTCAAGTGCACGGAGAACGACGGGGAGTCAAGGTGGCCTGTAGGACGTCGGCTGTGTGAGTTGCGTTGGGATACGTGTTTCCCGCATGGTAATGAGCCTCGATGGATAGATTAGAATCCAGCGGTGGAGGAGATCGTCGGAGCAGCCGAGCACATCGCAAACCTTCCACCTCTCGAAGACTTTCATTCCGATTTCCTTGGGAAAGAGCGTCGTGATCCGACACCTTTTCCAGATGGAGGATGTCGAATTTCCAGCAATTGTCGTTTTCCAGCGGGTGAGGGTCTTCACGTCAGCGGATACCCGTCGACATTCTGCATGGGATCCTCGCTTCTCTCGATGCGCGTCGACGACGCTTGCGCTGCCTAGCTGGATGATGGAGGCGAATGAGACAATCGTAATATTGAGTTGCCTATCCGATCGGCGTCGCGGAATCGGTTGATCGACGGTGCGTACAGCTGGTCCGACGACAGCACCTTCATCGCGTCCTTTATCGTTTTTGCCGGTTCTCCGTCGACCCGCGACACGTCTCGGAGCATTGTGAGCACCTCGGAGATGGGCGCCTAACGATGCCGCCAGTCCGCGATTTCAGGCTTTTCAGGGCGCCGTCGCGGATTGGCGGTACCGGGTTGGTGTTCTTGTGAGCGTTTCACACGAAGTGACTACTGCTAAATAGAATTTTTTGATTAATTGGTGGCCGAGCTTTTTAAATGGTTGCCGCGATGTTTAAGTTGATGGCAGAGTTTTATAGGTTGATGGCCTAGTTTTTTAAATCGTGAGTTTCTATGCAATTTTGTGGCCGTGTTATTGTATAAGTTGGTGGCGGAATTTTATAAATTGACGGCCGAGTTTTGTAGGTTGGCGGTCGAGTTGTATGAATTGGTGGACGGCCTAGTTTTACAATTGTGTGGCCGAGTTTTTGTATAAGATGTCTCGTGATGAGCCGAGTTTTTTCAAAATGATGGCCGCGATCTTAATGATGGTCGAGTTTTATAAGTGCCGAGTTTTATAGGTTGATGGCCGAGTTTTTATGTAATTTGGTGGCCGAGTTTCACAAGCTGATGGTCGAGGTTTATGAATTGGTGGCCGTGTTGCTATACAATTTTGTCTGGCGGTGTTTTTATATAAGTATTTGGTGGACGAGTTTTATAAATTGGTGGCCGAGTTTAACGGAATAAGCAAAGGAAACTAAAGCGAAAGTGCTAATTTTATTGAAGGGTTTTAAAAACTGGGCCATCACCTTTTCAAGAAAAACTCGGCCTCCAAATTTTCCAGCAAAATACTAGGTCGCCAGTTTTTCCAGCAAAAAAACTCGGCCACCAAAATTTCCAGCAAAAAAAACTGGGCCACCAAATTTTACAGCAAAAAAAAAATCGGCCACCAATTTTTCCACAGAAAACGGGCTAGTTTCATTGTTCGTTTGAGAGAAAGGTAGGTCACGTACATTTTCAATACGAATACTCGGCGACCAATTCTTTATAAAAAATTCCGTCATCAATTGTCATAGAGATTAAGTTCGGCCATCAAGGTTGAAAAATAAACTAGGCCACCGATTTTTTTAGTTGAAAAAAACTGCTCGAACACCTAACCTTAAGATTTTCCTTTTTTCTAGCCTAGAGCACGGTTATCGCGTTTTTAGGCCACCGATGCATTTTTTTAATCGAAACTCGAAAAAAAATCGGTGGCCGACTTTTTATCATATACGGCCACCAATTAAAAAAAACTCACTTGTTAGCAAACGGGACCCGTATCATTTTCCTGTCTCAATACCCTCCGTCCGCTTGCCGCTCCTCTTCGGTGCAGGGCCCTCGGGTGTACAGAGACTTCCGTCGCATTTCCGATGCGGGTTGTCCGAACACCTCGGATTATGCATCCCGTCACGTTCTCTAGCCGTAGGCGCAAGGATAACGTACTGCACTAATCGTTGCTCATCACATATTTCCACTGCTTGATTCGTCTGAAAATATCACCGCAAAATTTGAAGGTTTTTAGGCACATGTGGCGCCAGTCCATTTTGATCTACAAAAAATGCGGGAATTTTTCACCCAAAAATATATGATCAGCTCACCCAGTTCTTAACGATTCTAAACTCACCCGCATTTTTTGCACGCTCTACGTAAATCAAGCCGAAATAAGAGACACTCTGACAGCGCGTGTAGGCAGGTAGGCGTTCACCGAGCCAGGCGATTAGGCCAGGAGGCAGTCGATTAGGCAGACTAGTAGGAGGTAGGCAAGTAGGCATTGAGGCAAGAGCTCACCTAATCCAAGACCGCGAAAAGGGCTATGGGCAGCGCGCGGATCCGACTCGCGAGCCGCCCGACGTAGTCGAAGAGCACCACAAGCGTATTCCACGTCACATGCTTAAAAGAAACGCATGAATGGGAATCAGTGTGTATGAAATATAAATTAGAATTGTAAATGAGAAACTGAGAAAACGGATGACTTACCATGATGAATGATGTTGGAGTGCGCAAGAGCTCTCCCTCGCTTTTCGCTGATGTGTCTATGTCGATTGTTAGATTGACAATTCTGGCAGAGTGGTTTTCTAGAAAATTGGGGAAAACTCGGCCAGATATGTTTTCTTTGGTTTTGGTTGGATAATTTTGGCGACCGAGTTTTTCAACGTATCCTTTATGTGTCCGTGGCCGAAGGCACATAGAAGAAAATTAGAACAATGCCGAGTTTTATCAACGTAGTCTAAATTAGGTGTGGCCGAACTTTTCGTCTGACGGCCACGCAGCAAGAGGAAAAAATAATGAAACAAAATTTGGTGGCCGAATTTTAAGCCAACACAAAAAGTTGGTGGCCAAATTTTAAGCCAACGAAAATTGGGGGCGGAGTTTTTGTTTTTTGAAAATTCGTGGCCGAGAATATGGGAAAACGCGGCCACACGATATTTTTTCTTTGGTTTCTGGCTGAATAATTTTGGTGGCCGAGTGTTTTTGTTTTGGATAGGGCAGTTGTGGTGGCCGATTTTTATCATTTAAACCAAATTTACGTGTACTTGGACTTTTTCTGACGGCCACAATAGCAAGCAAAAAATAACGAAAAGTTGGTGGCCGAATTTTAAATTCATAGCAAGAAAAGTTGGTCGAATTTTAAGCCTAAAAAAAGTGGCGGCGCTTTTTCTACAAAATTCATGGCTGTCATTATTTTAATTGGAAAAACTTGTGGCAGTGATTTTGTCTCGAAAAAAATCGTGGCCTTTAACTAGTAAAATTTGTGGCCGACTTTTATTCGCGTAACCTAATTAACGTGGCTGTCGCCGACTAAGGCCACCTTGCAAGAAGGAAAAATACCCAGGCGAAACAATTGTGGCCGAATTTTTAGTCGAAAAAAATGGCGGCCGAGTTTTTGTTTAAAAAACCGTATTTAGTTGGGACGAAAAATGGTGTCCGAGGTTTTTCAATGTATCCAAACTTATGTGGCCTGTTAGTGGCCTATAGCCTAGCTTTCCTAAACCATTTGTTTATAAAGTTGGTGGCCTAGTTTTTAACCAGCATAATCCAACTCACTCACTTCTCGGCGATCGACACAATCAACACCTCCGCTGTGCTCACCGAGGCTGAGACGTCTCTGAAAAAAAGTTTCGTTAGTAGATCATGGCTGACGACGCTGCTCCCTTACTTGGCGATTTATCGAGCGATGGATGAGGTACTCGAGATCTATGAATACAGCTAGAGGGCATATTGATTAAACGTCGGATAGTGCAAGCAAGTGTACATAAAATTTCCGAAATTCAATTTCCTTTTTCCCTCGCCGCGCCACCGTGTCCGAATTTCGGAACTGACCACGTTTCAGTCGTCTTGGTAATTCCCAATTTCCTTTCTCCCTTTTTACGTCACATGATAGCGGTTATACGTGTTTCGATGCATACACAACAAGGCACTTAATCAGCTACTAGCTCCTCTCCCAACCTCCACAGAGAGACTGTATGAGCAAGAGAAAAAGCACCTGCTTCTTCCAGATTAGGCGTGAGCGAGCCTGTTGTCATCTGACTTCTGCTGACGGAGGGAGCTTGAAAAGCGGAGCAGGAAGAGGAGAAGAAATAAAGAGCATTCAGAAATTACGCGCGAGTCGTAGTAGCTATTTATACACTGACTTCGTCTCCTTCTTCTTCCTGCTTTTTCCCCGTCTGCTCCTTCGCTCGTTGATGTCTGCCATCATATTTCATTAACGAGGGCCTAAGAATCCTGGAAGAGTGACGTCACACTGATGGCCTCTACTAGGAATCTCAAAGGCAGGCCATATTGATTCATATAGCAGGCCATATCAGGCCCCATAGCCTGGCCATAGTAGGTCACCACAAGCTATGGACTGCCATCAGGATTTTGGCTCTTTGGATGATAAGCTTCTTTGGAGCCCAGCGCTTAACAGACTGACGTCGTGGTATCGAGAATCTCGGCTAGGCAGAAACGCGGCAATTGTGAATTTTTTGACGCACTAAAGATCTTATAGATCCTTGAAATCTTCCACAGGACTTAGCAGACCGGAGGCCTGGGAACTATGCAGTTAGAGGCGCCAAGTCCAATAGTGGGCTCCGAAGAGAGAGTGCCCAGAAGGGCTCCGAAAAAAGCGTAGATTTTGGGCCAAAATTTCCCAAATTGGGCCAAAATTTCAAAAGTAGTAGGTTTCAACCCTCATGTTTCCCGGAATGATTTTGTGGACTATTATTTACAGACTGTGGTGGCCTGCTACCCACAATATGTACTGGGCCAACCTCTGGCCAGGTTACGGCCTTTAATAGCGAATTGCTCTTCCCTTGGAGTCAAAGTTCTTGCAGAGCCTAGGAGACGCTTACCACTTTGGATCAAATGATCTAAAACTCAATGGATCATGACCCTAGAACCTCAATTTGACCCCTAATAAGCCTAATACGGAGCTACGTCTAAGCTCCCAGGCTATATGGCCTGATATGGCCTGAGCAACACTTCGGTGTGGCCCAGTCTAGGTTTTTCCAAGCCCCAGCGGGCCTCAGTTTTTATAAGCCTAAAGACGCAGCTACTGGGCCAAGCTCTGGCCTTGAATTTTGGAGTAATTATTGCAGAGCCATCATGCCTAGGAGGCCTAATCTAGATTTTTTCAAGGATTGAGGCCCCCACGAGGCCTCAATTTTCATAAGCCTAAAAACTCAGCTGCAGCCCTGCCTGTGTTGGAAACTGTACAAATCCTTATATGCCCGTAACGAGTCAAGAGGAGTACACTCTCGCCGGTGCCTTCCGTCACGATCACAGTCTGAAAAAGACGCATTATTTATAAGATCTTACAGGGGATTTTCAGATTAGGAGGGTCGTGTGCCAGACCTCAACAGCTCGCCGGGGGTGATAAAATGCTGATTGACTTGACATGCATATATATAGATATATATGAAGTTGGAAGAGCGGAAGCAGCAGCAGTGGCAGCAGAACTTGTGTGTGACGGGGATTTGTGGGAACAAGGCGCCAAAGAAGACGAAGCAGAAAAGCAGAAGCCAATGGGGGCAAGCAATGAATGCAATCTATGTAGGAGTATGTAGGAATATGTGTGTGTGTGTGTGTGTGTGCGAAAGTCTCTCTATCTGTGTGTGTGTGTGTCACAGGTTATATCGTGTGCACAAAAAATGTATAAGGTCTCCTGATGTGTGTGCGAGTCTGTGAGTCTGTGAGTGCAGTGTACAACACCTTTTGCGGAGTCTTACCACATACTGATACGAAAGTGTTTGTATTTTATATATTTCTTTGCCACGGCACACTCTTCAATTTTTCGCGGGCTCGCCCTGGCCCATCAGTGGCACGCAGTAGAAAAAGTAGTAGAATAACATGCGTTGTGGCCATAGCCCATCCAACTTTGTTACTTACGGACTGAATTCGCGCGCGCCGCGGGGAGGAGAAGCAGAAGACGACGACGACGAGCTCGAAAGAAGACGAGTTGCGCCTCTGCAGTGCGAGTCCCTCGGCAGCGGCACTGCTGCGCCGCGCGCTTCGATGACGCGAGCTCCCCCCCCCGGCGGGAAAGTACGCGATTTGTCACCGAGATGAGCGCTTTGCTGACAGAATAGAATGGGAAACACAGGAATATCGGATTGCAGTAGACATGTTTTGTTGCAAAGTTATGAAAGCTGGCTTGGCGTGGTCGTCGAATTTTTCGCGCTTCATTGACGGGAGAGAAGGGGAAAGTCGTGTTCTCCACTTCACGGAGAATCACACTAAGATTTAGGACTAAAATCGAGCCGAGCCAAAATGGCCTAGTTCTCGGCAGAAACTGTTCCATTTCAATCTGCGAGGAAAGCCAGAGTTCCGTGAACCTCGGCCCTGCGATCGCCGGCCTGCGATCTCCTAGACAAATGGTCACCCCAGCCGGGACTCGGGAAAGTTAGTGCCAGGAGAATAATTTTTGAATTTGAACAAAAAGAGGAACTTGTACAGTTTTACAGCATCTTCAATTGCATCGGCCCAAACGTGTTTGTGGAGCTGCTCGTTGGACAGTTAGCAAAGGTAGGGTTGGTGGAGCACCACGCGATCCACCTGCACCACCACCATTCTCAGGAATACGACCCACCGCAGCACCATCTCATTGCTAACACTGCCCTGGATGCTGCTGCTGCTGTTGCTGCTGGTGCTCTCTGTGCGTCTTTTAGCTGCGGGCGTGTGCTGCTGCCTCCTGCCAGCTTGACTGTGCTAGCCCCACACTCTTGTCACCCTCTTCTCAGCCCCCCACCCCGCTTCTATCGCCCATTCTCTCCACGAATTCTTCTGTCTGACCTCCTCCTCCTCCTCCTCCTCCTCCCAATTCTCATGTCATCGGGGGGCCCGTCGTTTCGTGGAGCGCCGCGCCTGCAATGTCTCGGGCCGCCGCCGTCGTCGTCGGCATCGGGTATCGTGGCCCGTCGTCTTCGGGGGGTGGGTTGTCATCTGCTGTGTTCACAGATGCCGCCGCCTTCACCGCCCATCTCATCGTCTCCTCCTCTCTGTGGACCCGCCGACCGCTTAAGCCCGCGCGCCTTCTCCCATCAGTTCTATCTCTCTCTATCACTCTCTTATCTCAAACCGCGTCAATTTATCTCTCTGGCAGTACTCGCTCTTCGCTCGGCGAGCTGTATTGGGTGTCGGTTTTCAGTCTGCGTCTCCGCGCCCCGGTGCAATGCATATGTTCCATCACGTTCTGCTCCTCCATAACAGGTTGCTCCGTGTGCTTCCGTGTTTTACGCAATTTGAGGTAAAATTGATACAATACAATTGATAATTATCGAAGTGTCCTCTATGTGTACTGACGCTGTTAATTTAATGGCCTAACCACAGAACTATGCTTCTTTAATTTTTGAACTTCTGTCGTAGCTCCGTAGTTAAATCCACTATGAGATTCCTTGCCATACTCGTTTTTGCAATATTTTTTGAGGTTGTTTGTTATGGAGAAAGTTTATGTGTTCTTTGCTTCTTTGGTTATATGGGAACCCAGCTGGCCAGAAGAATGGAAGGTTTTCTGGGACAGAGCTTTTGAATAGCCCACAATAGGGCCCCAGTGCCGGTAGGCAGGCCCCGAGGCCCCTAATTTAGTGCAGATAGTCCTTATTCAGCGTATAGATGATTCAAAGCTAAAATCAAAGGGCTGTTCCATTACGTTGTGATCTACAAAACATGCGGAATTTTTCGCCCTAAAAATGTGACGTCATCACGTTCCATGCGTTATTATTTATGAAGCTACCTCTGCGTCTCATTATCCCGCTTGAAGATCTAACGTAGATCAACCAAGCGCCTTACCCCTAGCCTCTAAGCTCACTACCTAGGGCCCTCTAGGACCTTATTTCGGCTTTTTGGACTGGCCAAGACCTCGCAATTGGGCTTTTAGGCTCCTAGGTCCCTCAAGGACCGTTAGTCTTGGACTATCTGAAACGATCTGCGTCTAGGCTCCTAGGGCCCTATAGGACTATTTAGGCCTCTTGGACTAGCTGACCATCTAGATCCTTCTAGGCCTCTAGGGCTCTCTAGGACCATGTTCACTTGTCTATAGGACCTGACTAGCTAAGACGGGCTTCTAGGCTTCTAGTAAGGGCGCTCCAGGACCTTAGCCCTCTGGACTCTCTAAGACTAATTGGGCTTCGAAGCTCCTAGAACCCTCTAGGCCCATTTAGGCCTCCTGGACGATCAAAGATCTTCTGGGCTTCTTCTAGGCCCCCAATTTCTAGGACCTTCTAAGACACCCAGTCTTTATATTCCCTAGCGTCTAGGCTCTAAGATAGGCCTCGTTTCCGCAATTCCTACTAATGGCTTTGGGAGACCACGTCACTTTCTAAGGCCCATGGACTTCCACAGTAGCTTTTCACGACAGCCATTTCCAAGTTAACGCACTCAAGGACCATTTAAGCCTTTTGGGCTATTTAAGACCCCAGATCTGGGCGATGACTCTTTTTTCTAGGCCTTTTGCCCTCTTGGGCGCTCCTGTACCTTCTAAGACCCTGGCCTTTTATCCCTAGCCTCTAATCCTCTAGGACTCGATTCCGTAAATACATTCCCAGTCCTAGACGCTCTCAGGGCCCCTGGGGTAGCCTTTCGGTTGACCATTTCAAACAGGCCGTTCCGCTCCATCTCTCCTTGCTCTCTCGTGCTCCTTTCCTCCACCATGTTCTCTCATTGTTCTGACGGATGGTGATGAGCATCATCATCCTCAAAGCTCCAAAGACAATTGCCATCAATGTGCCGCCGCTGTGATAAGTGGTGTTATTTCGCCGGGACAAAAAAAAAGGGAAAATTCTCCATGGGAATTTGCGACTAACACCTCCTATTACTGTAAAAAAACATCTGGAGAAGGGGGAAACGAACTAAAAAAAAACAAAATAAAATCGGCGTATCAAATTGAAGCTTCATCATATGATTCGTCGCCGTCGTCTGCTCTGTTCGGCAATGATCGTTTGTTCGCGTCGTCAAACTAACCTACTCAATGTCATAAAGAACAGAGAATGAATTCAATAAAACATGACGAAAAAATAAATACATTCAGGTACTGTAGCTAAATCAGGATCACATCTGGAATCGCTCTCAGCCTGTTCGTTTGTGGGAGCTTGTTGAGTATAGGCCGACCACTACGCCGCCGTCGACAATCCACGACGACATATACCGCCACCGACGACTACGTATGTCCCCTGAACTTTAAAGTTGCATTTTTTTTTAAAGGATTAGGGGTCTTTCGAAATAAATTTCAGTTTTGGTAATTTTTTAAATTTAGTTTTATTTTTTTACGGGCTTTTGCGATTATTACTGCTAGAATGAAAGTATGTACATTTCTTGTAGATCAGCAACTTTAATTTCTGATAACCGATAAATGTTCCGAAAAACTCGAAAAAAAAATAAATTTTTCCAAACTAACTAAAAAGTAAATTTATTTGTACAATTCAAAGTTTGTAATTTTTGACAAAATACATTCAGAAATCTTTTTGGAATAGGGGTTAATTAGGCTTGGGCCTAGGTTTGCGCTTGGGCTTGGGGTCAGGCTTAGGCTTATGGCTAGGCTTAGGCTAAGGATTGGGCTTAGCTGGCTTAGTGCGCTGAGGCTTGGGCTGGGGCTTAGGCTTCAACTTAGGCTCAGGCTGAGGCTTGTGCTGAGGCTTGGGCTTAGGCTTAGACTCTCAGGATTAGGCTTGGGCCTGGGCTTGGGCATGGACTTAAAAATGTTTTGTTTTTCAACAATTTGGTTGTTTTTCGAAACCTGATGGTTTTACCGGTATAAAGTGCCTTTTTTTGTACATAAAAATAATTTTTAAATTTTTTAACGTTCCTAAAAACTAAACAAACTGTAAAGAAAATTTTATTTAAAAAGCAATAAAACATATTCTTTTTCAGTAATTTCAAATTTGATTTCCCGGTCATAAAAAATCAATTTTTTATGCAGTCAGGGCCACAAAAAAAATTCGTTGAAAAAAATTCAATTGGATGTATTCTTCGTGCTTGCAAATTCGAGTCAATTTTCTAGGGATAAAATAGTTGTTTATTTTCCCTGATTTTTTGACGTTTTTTCCTTTTTTAAAGGATATTTTAGGACTTTCTGGGATTTAGAACGGTTTAGCCTAGGAGTGATTAAGACTAGGTTTAAGCCTGAACCTGATGGGCCTTACAAGCCTAAACCGAACCGCCTAAGCCTAAGCCTAAGCCTAACATCAAAAAAACCTGAGAATCCCCTAAATGGCGCAACGTCGAGTAGCAAGCTGATGCTCGCCACTGACACTAAGCCTAAGCCTCAGCCTATAACGAATAACAATTTTGGAACAAAAATTGCAAAATCTCCGCTTCTCCGCTTCTCTTAAGACATCGAATTTCCTAAAAATTTTTAGAAAAAAAAAATCCTCGGTCCAAACTGATCTGAAAATTCTATCATATTTAGGCTTTAACAAATTTCACTTTTTTCTGGGAGAGACACTTTCCATAACACCACAAATTCGGCGAGTCGACCTGTTGAGGATCTTGTCTCGACCCGCTCTCTCTCTAAGTGATTATAACAGAGATCCCACACCCACCCACCCACCGTCATCTATTATGTTCTAGAACTTTATACATTATGATCAAAACCGAATGCTACAAACTACAAAACATCGCCACTTTTTCCAAATTTTCGGCACATTTTTGCAGTCCGACCACAACTACAAGCACCAAATCCATGTGAATCATCGCATCCGTTGGATCTGACGCGTCGGCTTATAGACGGGACACTGTGCCGGCTACAATCTTCTCTATATGGCCAGCGACTTTCCCGTCGTCGGCTCGCAATGAGTTTCCTGATCTCAGGGGTTAGGCTCACATTCAACGGACTATGATCGGGAAGAGGTGCCTCAAACGATAAGTGAGCTCTCAATGCCTACCTGCCTACATGTTTGCAGTATCAAAGATATGATGCCTACAAGCCTACCCCCCTACCTTGTCCTACGAGCCTGAACTTACACATTTTCTGTGCCTAACATGCTCGCTATACTTTTGTCTGCCGTTACGCGCCCCCCCCCCCGCCTATCTGCCTCCAGAAGTCTCCATTTAGTCTTTATGCCTGCACGCCTATCACAGGCCTCCCATTTGCTTGCGGTCGAGTCGATTCATGCCTACGAGCCTGCGCCTTACTAGCCTGAATTCGCATTTTTCCAGTGCCTAGCATGAGTCCCTATGCCTGCATTTACGCGCCTTCTCCCCTAGCTGTCTACAATCGCACTTTCTGCCTACCTGCATGCTTTCCTACCTATTCGCAATACTTAGGCGTACCTAACACAAGCTTAGCGACTACAAAAGCCTTCCAGTGCCAACCAGCTGCATGACTGCGTAGCCTTTCGCCTGCTTAGGTGCCTACCATAATCCTCCCTTTTGTCGATATTTCTACGCGCCCATACCTACATTCCTATCTTGTTTGAATCGATACATATCATGCCTACGCACCTACCTTGGCCTACCTTGGGCCTACACTCCTGAAATTGCACTTTTCCTGTGCCTAGCTCGTACACTATACTTATGCCTGCCTTTAGGGCTTTCTCCGCGCTTATCTGCCTACAAGCATACCTTCTGCCTCCTTGCATGCCTTCTTATATTAGCCTGCTTACCCGAACCTACCACAAGCCTGGCTGCCCAAACTTCCCTTCTGCCTATATGCCTACGCAACTCCTGCCTGCCTATACGTCTACCTCATGCTGTAAACAGACCTGCCTTGTACCTACCTATGCGCCTAAAGATTGGCTGTCTCCTACGTCTGCCTGGCTGCCGGAATATTTTGCCTATAGGAATTACTGTCAGTGCGTCTTTACCCAGATCCTACCTTTAGGTAGACGTCCCCTAAAGCAACCGCCTGCAAGTCTATCACTTCGCCTCACGCCTCCTTGCCTACCTACACACCTCCCTTATCCCGGCTTTTCCACCTGCCTATGCCTATCGCATGCCTACCCTCAAGACCTGCAAACGTGCCTAGCCGTATGCCTACCTAACTTCGCGCCTACATATGCCTCCCTTTCAGATCGAGATTAAGTCGGAAAATAAAACCGGCCAAGGCAGTAGCCTCCTTGCTGGGACGAGGAAGAGTGGGAGGAGGGCGAGACGGAAACGAGCCATCAATGGAAGGATACAGATGATCGCTATCATGCGAGATACCGGAACACGTCATATTTTGGTAGGTGGGTGAACACAGCAAGTGCGCTCCATGGCGCGGGACACTTTTCCCGCGCTTTTTAGGTCAAACACGTAATTTTTCCAGTAATGACTGTGGCGGTGGAATGCGATGATGAGACTGGAGATTTAACAGTGGTGGATACTCGTTGTACTAGGTGCCGTGCTGTTCGACACTTGCCATCCACGTATTGTCCACGTTTAATGAGCTGATTTGCTCGCAGAAAGCGTGTCTGCGAGAGGAAAATGCATACAACGGGTGATGCCGATGAATATGTAATTTTTTTGTTTTTGCAGTGGAGCGCGTTTGTACTCACTCCACGAGGAAATCACGTGGTGTGAGAGTGTCTTTCGGATTGATCTACAAAAAATGCGGTAGAAGAGACACAGAGTTCTCAACTGTGGATTATTAAGAACGTGCTCACGACAGACATTTTTATGGGCAAAAAATAGGCATCCCGCATTTTTGGTAGATCAAATCAATTGGAGAATAGTAAACCTTTTTATTTGAATATGATCCTTTAAAGAAAAAATAGAAATTTGACTGAATTTCCCGCCAAAAAATTTTCGCAGGTAAAAATTTAAATTTCCCGGGAAAATATTCACGGATATCCGGCTTCCCTCATAAATTGAAATGCAAGATTTTTTGCCGAATTAGGCCAGCCCATATCTGGGGTATATTTTGAAAAGGCTGCGTGTCGCGTCGCGGCTCGATTTTAGTTATAAAAGTAAATATATACGCATTGTCCGTGTGGAGTACAAGACTTTCCCACGCGTTGGTGATTGTCAGTGCGAAAAATTCGAAAATGAGGAAGGCGAGAACCTCGTGAATATTTTCTCAAACATTTTGTTTTTGGAAATAATGTGCAATCGCGCTCTAACGCAGTATCCAAAACTTGAGGCTTCTGGCGGAAAACTCGAAAATCAATTTTTTGCTTTAAAATCGTGAAACAGACGAAACTAGTCGCATAATTCAAATTTACGGTATTGCCGCGCCAGTGCGGTGGATCACGTTTGCACTTAAGAAAATTGGTGAAAATCAAAAATTTGGTTTATTTTTGGCAACTATATTTCATTCTCTATTAAATTCATACTGTACACGTGGAAAATCATTGATTTTCCCGAAAATATAAATGGAAGATGCAAGCGCGCCCTATTGTGGTTCGTTAAAATTCGAAGCGTAACTGAAATCGAAATTTTTTCTCGAAAAATTGCAGTGTGCCCGTTGTAAAATATCGTTTTTGGAAAATTTAATATTTAGAAGTGCGGATGCATCCTATTGTGCGCTTCCAATAAACTTACACGCTGGCATGGGATCCGAATTTTCGCGTCGCTTCCATTGACAATCGCCCGTCTACTCCACAAGGACAAGTGCATTTAGTTTTAAAACTAAAATCGAGCCGCGACGACGCAACGCGCTAAATCTACCCCAGATATGGCCTCAGGCCTTCTAGTTCGGCAAAAACTCTTCCATTTCAAAATATGAGGAAGGCCAGAACCTCGTGGAAAATATCGATTTTTCCGTTTCCACGTGGCCAAAGGAATTGCAAGCGCGTTCCAGGAACGTGAACTCGCACATTTTCCATTTTTTGTTCTCCGAAACGTGGGTACACCCGCGAGTGTGCTCGCTGGCAAATGAGCCAAATCGACGTGCGAACGTGTTGTGATTGTATGCTCAATCCGTCATCACCACTGGTCACCTATTTATGAGCGAAAAAACCGGGGAAAAAAACACACAAAGACAACCCAAAACTCAACAAAACAAATAATTTTACAGGATTCAACGAACACAACAAAAAAAAGAAACAATGGCAATTAAATACGGAAGCTGCTGCCAAATATGCTGCCAAATTCAAATTCTCGCTAGAACTTGTACACACGATCTTTATTGAAAACGGTGATCAACGGGCACCCACCACTCTGACCTTTTGAAAATAATTGTTTTAATGATTTGTGTCATTAAAAACCTCGGCCACGGCCGCGACGCCGCCGCTCCGCACGCAGCTGCGTCGGCGGTGGGGTGGATCCTGAACTTATCCCTCCAGCTCGTTATCGTCGTCGACCACCTCGAACAGTTAGCCTCAAATAGAAATCTGAAAAAAATTAATTGGTTTATTCTTTTTGAAAATATATAATTTTATGTTTGGGCGTCTTTGTGGCCTTCCTCATTGCCTTTTTCGCGCGCTCCATTGACAATCGCCCCCCTATGTACTCCAAACGGACTAATCACATCTAGTTTCACAAACGAACGACACGCAACGCGCGTGGCCTAGTTCAGAAAAACTCTACAATTTCAATTTATGAGGGAAGCCAGAAATCCGCGTGCGTTTTATTGATTTTAATTGATTTTTTTACTTTCGAAAATCCCGTTCCGGAGAAGCACAAGGTTTTGCGCGTGTCGGCGATTCGATCCCTCGCTTTACCCCATTATCTGCAAAAAAAAGTACTATTTTTTTTTGTGTAAAATTCCCAATCTGCGAGGGATCTACAAGAAAAATTTTTTGTCCTTTTAATATTTTAATGATTTTTTCAGAGTGATCACATTCTTGCAGATCCTCTTTTCGTGGGGCCTCATAATTTTTCAGTGCTTCACATTTATTTAACATAAAAGTGATTTCTTCATAAAAATTTGAATTTTTTGCCCAAAAATCGAGAAAACCGCCGCTCCGGCTCTTCTTCCGTGCGGCACTGTGCTTTTTGCAAGCTGGGCACAGTATTGTAGGCTTGAGTATGGTCTTCCTTGAGCGCTTGAGTCAACTACGAAAAAAAAAAAGGACTTTCTTTTAAATTTATGTCGGAGATACCACATTCTTGCAGATCAGGGGATCTTTTCGCGGGCTTATTTTTCAGTGCCGCTCGGAAAAAGAGGCGGAACGTCGTGACGCACGGTTTTTTGTCACGATTACAGTTTGACTAAAATTGTTGATTTTGGATCATTTTCGTTGATTTTTTTCGAAGCTGATTTCGGCAAAAAAAAAGTTTTCGCCTTTTTTTGGACAACGAAGAGCCAAAATATCAATAAAAATGAAAAGCTAACTTCATAAATTTTTTAGGATTTTTACATTTTTTTTTTTGAATTGAAAAATGTTTTTTTTAGGTGTTTTTGGTGAAAAAAACTACTTTTTTTAGCTAACAAAAAATATCAAAAACTAAATGACCAAAAATCGGAAAAAAAAAACGCCGCGCCGCCTCTTTTTCCGTGCGGCACTTCGCCATTTGGAAGCTGGGCATGGTTTTGTAGGCGTTGTCATGCTGTCATTACTTGAGCGCTTTGAGGCAAAGACTTATGGGAGAACGGTGATTTAAATCCAAAATTGTCCCGGTGGCGTTCAGGAAGAGACGCGGGGGCTTCTGAAAAAAATTGTTGAAAGATGCAAAAAATCTGAAATTTTAGAGCATTTTTCTGAAAAAAATGCAAAAACCGAAATTTTTGAGCATTTTTCTGAAAAAAACGCTAAAACTCTGGAAGCGCATTTTAGATCATTTTTCTGAAAAAAACGCTAAAAATCTTAAAATTCTGAGCATTTTTCAAAAAAAAGATTCTTGTGCACCTCTGTGAAAACTTCATCCATGATGGTAATTGAAAAATAACAACTGTCCAAAAGCATCGAATTCACAGTGTCGAGTTGGAAAACGCCGACATCTTCGACTACCCTAAAATGCTCATAATGGGGAAAAGCTCTAAAAGCATCGGTGGGCTTCACGCATTCCTCGCGTTGTGTTCGCTCCATTCACAATCGCCCCCGTGTACTCCACGCGCACAAGTGCATTTAGTTTTAAAACTAAATCGAGCCGCCGACACGCAACGCGCCGTAAATCTACGAAAAAAAAAAGGCTTAATTGTTGCTGAAAAATCGATAAAACACGTTAAATTTAATCAGAAAAATCAATTTTCGCACAATAAAATTCGCAAAAAAAAAAAATGAAATTTTTTCGCTCATAAAATTTGGCGATGCTTCAGTTTCGTCTTAGGTTCACCGACCCGAAAAATCAAATTTGACGCGCAAAACTTGAATTTTCGATTGATTTTTGATGAAAAATCGATAAATTACGGTCAATTTAACCAGAAAAATCAATTTTTAACGAGAGAAGCCAGAAATCCGTTGAAAAAGTAAAAAATCAAAACACAAACATTCGAGAGAGTCTCTACAGATGACGGAGACAGGGAACGCATTTTTTCAGAATTTTTCTGCAAGTTTAGGTCCAAAACTGACGAAATAGAAGACACTCCGGGAGCACACTGGCAATGTCATGAAAAAAAATTAATTAAATGCTAGATTTTTAGCATTTTTTCAAAAAAAATGCAGTAAAATTTCAGATTTTTAGCATTTTTTTCGGAAAAGTACACTGAACATCATTTCAGATTTTTATTTATTTTTTTTTGAATGCTACAGACCGAATAGTTTGCCAGGCATTCGAGGAGGAAATCGGCGATGAACTCTGCCACGTCGCGGCATTCGATGGGCGGGGGCTGAAAATATGCAATTTTTTGGCCTAAAATTTGGTTTTTTCTGGAAAATTCTCTTACCCCGATAATGGGAAGGTTTTCGTCTGCGGAATGCTTAAACTAACATACAGCCCTCGGAGCAATTCTCCACGAATTGGAGCCACCTCCTTGGCTTAAGTGAGAGATCATAGATGAAACTGAGCCGCTTCACCATTACGATGCTCTTGCAGCGTTCACGAGCGTTCAGCGTGTTTTTCCAGGATACTCTGAAAAAAGCGCTAATCCTTAATTTTAGCCAAAAAATCCATTACTCAATTTAGCAAAACAATCCGTTAATTTTAGCCAAAAAATCCGTTAATTTTAGCAAAATCCGTTAATTTTAGCCAAAAAATCCGTTAACTTTAGCCAAAAAATCCGTTAATTTTAGCCAATAAATCCGTTAATTTTAGCTCAAAAAATCCGTTATTTTAAGTCAAAAAATCCGTCATTTTTGCCAAAAAATTCGTTATTTTTAGCCAAAAGTTCGCTAGTTTCGGCCAAATATAATCCGTTAATTTTAGCCAAAAAAAACCGTTATGGGGTTCCAAAAAATCCTTTAATTTTAGCCACAAATTCGATATTTTTAGCAAAAAAAATCCGTTAATTTTACGCAACGAACCGTTAATTTTAGCCAAAAAATCCGTTAATGTAAGTCAAAAAATCCGTTAATTTTAGCCAAAGTACAAATCCGTTAACGTTTAAGTCAAACCATTTTAGCCAAAAAATTCGTTAATTTATAGCCAAAAATTCTAGTTTCAGCCAAAAAAATCCGTTAATTTTAGCCAAAAAAGAACCGTTATTTTTAGCCAAAAAATCCTTTAATTTTAGCCAAAAATTCGATTAGCAAAATCCGTTAATTTTAGCCAAGAATCCGTTAATTTTAGCCAAAAGTCCGATAATTTTAGCCAAAAATTCGATATTTTTAGCAAAAAAAATCCGATAATTTTAGGCAACCGTTAATTTTAACAAAAAAATCCGTACTTTAATAGCCAAAAAGAAATCCGTTAATTTTAGTCAAAATATCCGTTAATTTGCCAAAAAATCACCACGTTAATTTAAGTCAAAAAATTAATTTTAGCCAACAAAGACCCGTTATTTTTAGCCAAAAAATCCGTTAATTTTAGCCAAAAATTCGATATTTTTAGCCAATTAAAATCCGTTAATTTTAGCATCCGTTAATTTTAGAAATCCGATATTTTTAGCAAAAAAAACCCGTTAATTTTAGGCAAAGAACCGTTTAGCCAAAAAATCCTTTTATTATAGCCAAAAAAATATTATGTCAAAAAATCCGTTAATTTTAGCCTAAACAAATCCGTTAATTTAAGACAAAACCGTTAATTTAAGTCAAAAACTAATCCGGTAATTTTAGCGAAAAAAGAACCGTTATTTTTAGCCAAAAAATCCTCTTCGCCAAAATTTCGATATCTTTAGCAAAAAGAATCCGTTAATTTTAGCCAAAAATCCGTTAATTTTAGCCAAAAATCCGTTAATTGTAGCCAAAAATTCGATATTTTTAGCAATAAAAAATCCGTTAATTTTAGGCAAAGTTAATAGCCAAAAATTCGATATTTTTAGCCATAAAATCCTTTAATTTTAGCCAAAAATTGCTAATTCTTTAGCAAAAAATCGCTATTCGGCGTTTAGCCAAAAAATCGGCGTTAATTTTAGCCAAAAAATTCGCTATTTTTAGCCAAAAAACTGTTAATTTTAGCCAAAAATAGACCGTCGATTTTAGCCAAACAATTAGATTATTTTTAGCCATAAAATCCCTAAATTTTAGCCAAACAAATCTGTTATTTTTATTAAATAATTCGTGAATTTTAACCGGAAAGTCCGTTATTTTTACTACAAAAATAGCGAATTTTCGCCAATTATAACCAAAATCTCTCGATTTTTTGCTCAAAAATGCACCTAATGTGCGTTTTTCCTTTTTTTTGGCAGTTTCCCTACTTCAATAGCGAGTTTGCAGGCACGTCGTCGTGCAAATTTTGACTTCGATTGCAACAGAATCCAGCAGAATTCGATCGTCAGTCACTTAATACATTCCAAACAATTTTCAGATCCTTTATGGGCACTTCGATGTAATCTGAGAGAGCAAACACGTTAGAATTGCCAGGGTTTACAGCCCTCTTTTAATCACCATCCAACTGGAACGCGAGGTCCATCTTTGGCTGCCATACCTTCACCCGCTCGCCGCCACCCTTGCAAATGTTGTGGATAAATTGAACGGTTCACTCGAAATTCTCCAGATCGCCGTGCTCGACGAGCGCGTTATTCGATGGGTGTGCTCTTTCCGGCTTCTTTTCCTTCTGAAACTGCTGTTTTTCCTTTTTATTTTTTTATGTCGCAAAATTTTTTTTCCGAATTTTTCACGGCACCAACCTGAACAGCGAATCTTCGAAAAGAGACGAAGCGATTTTGGGCTTTTCAAATTTGAAAAATTCAAAGAAGTTGTCACGGAACTAGCCATTTCGAAGTCGAATTGATTAAAAATCAAAAGCAAAAAATTTCGATAAAAAACAGTGTCCGAGAGGAGTACACGCTTAGCCGGGGAACCATGCGCGGGACTCGCACGGAAGAGACGAATTGAAGAACAGCTCGTAAATCCTGTTCCACGCTTTTTTTTTAATTTTTTCAATTCTACTTTTTTCCCAGAAGTTCTTGAAAATATCCTTTTGCAAATTTTTCGGAAAAATGCTCTAAAATTTAAGATTTTTAGCGGCGATTTTTTTCGGAAAAAAATGTTAAAATTGCAGATTTTTAGCATTTTTTCACAAGAAATGCACTAAAATTAATATTCTTAGCATTTCTGCGGAAAAAATTAGCTAAAAATCTTGCACATCAAAGACTGAAAAGAATTTGTTGTAATATTGCATGGATGTTCTGAGGTTTTACATCAAATCTGGGTTCCATGAAATTTGACGTTTTTCACTGAAACATTCTACAAAAATAATTTCTGCGCTCTCGCAAAAGTTAAGATGAAATAATCGCCAATTTTTCAATAGTGCACAGAAACCGTCAGATTTTTAGCATTTTTTCGCAAATATGAAAATTTTAGATTATTAGCAATTCAGAATGCTCTAAAATTTAAGATTTTACCTTTTTTGAGAAAAATTCACTAAAATGCAAGATGTAACTTTAAACATTTTTTTGCAAGAAGCTCTAAAATCAAAGTTTTTTAGCATTTTCTTCGGAAAAATGTTTGAAAATCCCTTCGTTAACGCCTTTTTCGCACTAAAAGATGCTCAAACTAGTTTAAACTTTCAGAGTTTTCCCATGCTTTTGCCCCCTCCACTTCACAAGAAACAATGAAACGAATATGGCGGGATAAAAGCGAAAATTCGGGGAAAACATCATTTTCAATGCATTTTTCATCGCGAAAGCCGAATTTCATTAAAAATGGCCAATTTTTGTGCCAGGTTTCCCAATTAATCTTGTATTTTCGATTAACTCAACCCCTGCGCAGAGAAAATCACAAAATGCAATTGTTTGTGTAAAGCACTTCTCTGCGCGTTTGCGGCATCCGATATGACGAGCAACATATATCTTTTTTCTGGAGCCCTTTATTTTAAATTTATCATTTTTCATGCATTTTTTGAGAAAAAAACTCCCCCAAAATTAACCTAGAAGCCTTGGAAATGAACTTGAATTTTGTGAAATTTGACGTTTTTCAGCGAAAAATTCTCAATCTTTAGTGCATTTCTGCCGGAAAAATGCTAATAATCTTGAATTTTAGTGCTTAGTGGAAAAAACGTTAAAATCAAAATGAAAGAATTTGAAATAAAATCAGAGGCTTTAAAATTTAAGATTTTTAGCATTTTTCCTGAGAAAAGCTAAAAATCTAATTTTTATAGCTTTTTTGTTGAAAAAATGCTAAAAATCTTAAATTTTAGCTCATTTTATTTCAAATTCGACATTTTCATTTTGTATTTAAGAAAAAATAACCTCAAGGTCTGAAAAATATCGAATTTTGAATGAAATTTGACATTTATCAGCGAAAAATTCTCATTTTTCCGGAAAACATGCTATCTTGTAGTGCATTTTTCCTGAAAAAATGCTAAAAATCTCAATTTTTAGTGCATATTCCCGGAAAAATGCTAAAAAATAGTTCTTAAATTTTAGAGCATTTTCCAGACAAAATGCTTAAAATCCTTTTCAGAGAAAGGCTTTATTAATGAAAAATTGCGCTAAAAATCTCTCTAAATTTTAGAGCATTTTTCTCGAAAAAACTTAAAATCTTGAATTTCAGTAGTAAGCATTTTTTTCGGAAAAATGCTAAAAATCTCAATTTTTAGTGCATTTTTCTGAAAAAATACTAAAAATCTTGGATGCTAGTTTTAGAGCATTTTCGCTGAAATATAACAAAAATTTTAAATTTGCATTTTTCCGAAAAAAAAAACGCTAAAAATCTTGTAATAACTGACAAATTTCGAATTTTGAGTAAATTTTATGGCATGTTTTTCGAGGTTTTTCCTTGCAATTTGTTTTCACCTAAAAATTCGACAAAAATGAGCATTTCTGAGCTCTTATATGGCAAAAATTGACAAAAATCGTCAATTTTTCAATAAAAATTGCCCAAAAACCTTAAAATATTCTGAAAAAAGCCGAAAAAACCCCATTTTTTAGCCATTTTCTATAGTATCTTACATTGTTCTCAACTTTCTTCACCTAAAATCGCCGGAGATATTAACATAAAATACCCTTTTTTTTCAGCGCAATGGATTATGAGCCAGGAGGATGAAGCAGCGAAACCAAGATCCGAAGATTCGCGATTGGTAAAAAGTGGGGATTTCCGTGAAATCAAACTCGATTTTTTGTGAAAATATAGAAAAAGCATGAGTTCACAACTGCTCCAAAAACCGAAAAATTTCACTAAAATCTAGAATTTTTGCCCGACTCGAAAACATCAAACGCAAAAATCGCCAAATTTGTGAAAACTAGATTTTTATTTTTAAAAAATTCTAAAAGTTCATAAAAATCAAAAAACCGGATTTTTTTTCTTAAAAATTCTGGAAAACTGTCTAAAAATCTACTCAAAATCAGTTTGTAGAAAATCTGAAGAATAGTCTAAAAAGAATTAATAAGTTGGGAAAAAATTTGAAAAATTACGAAAAAAATCAATATAAAATCGGTTTTGAGCTTGGGAAAAAAAACCCTGAAAAATTGTCTAAAACTCTATAAAAAATTGGATTTTTTAAATAGAAAATCTCAAAAACTAAGAATCAACAAAAAATCGAATTTTCCGGTGGGTGAGAAAACCTGAAAAATTATCAAAAACTTGGTTTTTATCAGAACATCTGAAAAATTACCTAAAAAGCAATAAAACATCAGGGGGTTTTTTTTCTGGAAAAACTGTAATATAGCCTAAAAAGCAATTTAGAAAAAAGTTTTTTTTTTTATAGAAACTACTGAAAAATTATCAATCAAAACCACGAAAAAAGATACATCTTTCGCTTATGTCCAAAAATCCCAAAATTTGCATTAAAAACTAGATTTTTCCGTATTTCAAAAAAATTCAAATTGCCTGAAAATCAATAAAATTGTTGTTTTTTTTTGGAAAGAACAACCCAAATTGGCTAAAAATCCGCAAATTTTTATGCAGCTCAAAGAACGAGAACTCAATGGTCGCGAACCATCAAGCTTTTCTGCCTCCTGGGAGCCGGCGACTCTGGAAAATCGATTTTACAACCAGATGCGTATCATTCACGACGTAGGATATACGTCTAAGAGAGAATAGTGTTCAGAGGCTTGTGGAAATATTATTTTGGTCAGTGCTCCGATGCACTGAACAATTACCGGAAATTGGCAAGACCAAAATTCGTGGATTTTAACCAGAAAATCCGAATTTTAATCAATAAAGGCTAATTTTAGCCAAGCAAAAATTCGCTATTTTAACCAAAAAATCCGTTAATTTTAGTCAAAAAATTCCCTCATTGTTAGCCCAAAAATCGCTATTTTTAGCCAAAAAATCCGTTAATTTTAGCAAAAAATGTCGCTATTAGCCAAAAAATCCGTTAATTTTACACCGGCAAAAAATCCGTTAATTTTAGTCAAAAACTAGCTCCGCTACTTTAACCAAAACATCCGCTATTACCAAAAAATCCGTTAATTTTCGGCAAAAAATTCGCTACTTTTAGCCAAAAAATCCGTTAATTTTAGCCAAAAAATTCGCGAATATTTTTAGCAAAACATCCGTTAATTTAGGCAAAATCGCTCATTTCTAGCCAAAATATCCGATAATTTTAGCCAAAAAATTCGCTATTTTTAGCCAAAAAATTCGCTGTTTTTAGCCAAAAAATCCGTTAAATTTAGACAAAGACAAATTATTTTTAGCCGCACGACAATTCACCAATTTTCGTTTAAGATCCAATTTTTGACAAAAAAATACACCGAATTTACTCAGACGCAAATTCTCCCTTTTATGGCTAAAAAATGCATAAATTACACAATTAAACCAAAAATTACCCAATTCCCAAAAACTCTAATTTATTTACCAAAAATTCTCCTATTTTTTGTTGAAAATTCTCCAATTTTTTTGCCAAATTTTAACAGAAAAATCTATAAAATATCAGGCGAACCTAATTTTGGTCAAAAATTCACCTATTTTTGTTCAAAATTCTACTCACATTTTACCCAATATCCACCAAATTTTAACAAAAAAAGCTAAAAAATTATTCAAAAACCTAATTTTCGCCCAAAATTTTCCATTTTTACTCAAAAATTCCGATTCTCTTTTTAACCAAAAAATCTAGAATATTAGGTGAAAAATGCCTAATTTTGGCTTAAAATTCACCGATTTATGGCAAAAAAAAGCCTCCAATTTCTGCTTAAAACTTCTCTGCTTTTTACCAAAAAACTCTAAGATATTAGGCGAAAATCACTAATTTCGGCGAAAAAATTACCAATTGACAAAAGAAACTCCAATTCCAATCACACAAAAAGTTCACAAAATTTACTCAAAAATTGTCTGTTTTTCACAAAAAAAAAACCTACAAAATTAGGAGAAAATTCACATCAATTGCCAAAAAATCCCTAATTTTGGCCGAAAAATTTGCCAATTTTGTTAATTCAGTCCAATTTTCGACTAAGAAAACCACGTGCCATTATTTTCAGCAAAAAGTTGACCAAGTTTACTCAAAAATTGATACAAAAAAAGTCTATTAGGCGAAAGATCCCTAATTTAGTCCAAAAATACACCGATTTTTGACAAAAAAAACTCTAATTTCAGCAGAAACTTCAAAACCATAGCCACAAGTTCACTGTTTTTTACCAAAAAAATAGAATATTAAGAGAAAATCCCTAGATTTGTCCAAAGAATTAAACAAATGCCAAAAATGCTCTGTCCGTTTTTTACCAAAAATTCTAGAATGAAATTTTTTAGGCAAACAACATCCCTAATTTTTCCCAACAAATTCACCGAATTTAATCCAAAATGCTCTGTTTCAAAAACTCTAATTCCAGCACAAAATTTACCAAATTATAGCCAAAAACGCTCTTTTTTTTCCAAAAAAAATCTAAAATAGCTTAGGCGAAAAATCCCTACAAGATTTTGTCCAAAAATTCAGCAGATTTTTGACAAAGAAACCTCTAATTTCAGCAGAAACGTCACCAAACTTTCATAGCCAAGCAAATTCACTGTGTTTTTTACCAAAAAAATAGAATATTAAGAGACAATCCCTAAATTTGTCCAAGAAATTAACCAAATTATAGTCAAAAATGCTCTGGTATTTACCAAAAATTCTAGAATATTAGGTAAAAAATCCGTAATTTCCCAAAAGATTCACCGAATTTACTCCAAAATGCTCTGTTTTTGACAAAAAAAAACTCTAATTCCACAGTCAAAATTTACCAAATTATAGCCAAAAATGCTCTTTTTTTTCGAAAAAAAATCTAAAATATTAGGCGAGTGAAAATAATCCCTAATTTTGGTCTAAAAAATTACACCAATTTTCCCCAATTTAAGCTTAAAATGTTCAATTTCTAACCAACAAAAAAACTCCCAAATTTTAACCCAAAAATTCCCTCGAATTTCACCCCAAAACCGTCCAATTTTCCAGTCTTTCAACGCCAACACAGGCTATGGAGCAGTTAAAAATCAGCTTCACACACTCGATAATCAGATGCCCGAAAGCTTCTAATGTTCAGCACAACAGGCGAAGAGGATGAGCTGTCGAGGTCGTCGGGCTCATGAAGCGTGTTTGGTTCGGGAATTCAGAAAGCGCTCGAAAGGTGGCGAAATTTCGCTGAAAATTGAGAAAATTCGAGGGATTTTCGCTGAACATCGAGAAATTTCGGTGGAAATTAGCTTATGTCCATGAAAAAATCGTTAAAATCCCAGAAAATTGCGATTTTGACTATTTTTGAGCATTTTTCGCCTTTTTTCCATGAAAAATTCAACGAAATCTTTAGGTCATACTCGCTCTCAGGAAAATTACCGCGTTTTTCGATGAAAAATTCGTTGATATTCGTTGAAAATTATCTATTAGAGATAATTAAAATTTAAAATTCCAGACAAAAAAATATTTTAAAATAATTCGAATTATTTTTGGCTCACACTTTCAAAAACCTCTAAATTCTAAAAAAAAAATTTTGGAGCCCCTTTTCCGGTCTAGAAAATATTTATTACCCAATGATCAAAATCCGGGAAAATTCAGAAATATTTAAGTTTTTGGCTATTTCTGACCTCACTCTTACTCCCACACAAAAATAGTTTTACCAAAAAAAACGGTAACAATTTTTGTCAAAAATTCGACAAAAAAAGTACCTTTCTGGGAAATATTTTTAATAATTTTCCCCTGTTCCGAATATCGATGTGAAAAAATTCAGAAAAATTTTCCGCGATTTTATATGATTTTTTGAAAATTGAACAAATTTCAGTTTTCCCCCCTAATTCCTATTTTAGTTCAATTTGATTTGTTCGATGGACTTGCACACGTTTTTATTAATCTATTTTATTTACTTTTGTTGATTTTTCCACCTCCCGATTTTTAATGTTTTCGGTGTATTTTTGCTTGAATTTTAGCACTGGGAAAAGTCAAAATAAATGCAATTTTCGATTAAAAAGCACGCTGCCCGGCGTAAAAATGAATAACGACTTTAAACGATTTCAAACCTGAATTAATTAATTTCACTGATTTGCGCATGTACGCGTTCGTAGATCAGTGAAATTAATTAATTGAGGTTCGAAAACGTTTACGGGCAAAGCACTTTTTAATTTTTACGCCTGTAAAGCGTGCTTTTTAATCAGAAACTTGCAATTATTTTGACTTTTTCTATAAAATTCAAGCAACAAAAAATACACCGAAAGCATCAAAAATCGATGGAAAATAACAAAAAATAAAATTCTTTAAATAAATTTAAAATTGCGCGAGCGCGCTCCATCGAACAGAACACCGCGGTAATTCATATAGGAATTAGTCAAAGACTGAGATTTTTGAGGCACCACGTTACGGTTTGAAAATCTGTTCCAAAAAGAAGTTCTACGTTTTCGGGATCTGGCACCGTGGCAACTGCGGTTTTCTCGATGAAAAACGTAACCACGATGCGATGTTACGCGTCGCGTGTTGTTTTGCGTTCAGAAAGTACATTTTTTGAAATTTTCTTCTTGATCCTGAGAAACGCTTAACGACACGCAACGCGTAACAGCGGAGCATCGATGTTACGTTTTTCATCGAGAAAACCGCAGTTGGCACGGTGTCCGATCCTGAGAACGTCGATCTTCCTTTCGTAGATTTTCAGAATGTAGATCTTCTTTTGGTAAATATTCTTTTCGTAGATCTTCCTTTCGTCGATCTTCAAAATGGAGATCTTCTTTTGGTAGATCTTCGTAGATCTTCTTTTCGTAAATCTTGTTATTTGAGCGTAGATCTTGCTTTTTGAACAGACGATATTTAGAACGTGGTGCCTCTGATCAAATTTCAAAAAAGCATATAAAATTGAGAAAATTTCCACGTTTTGAATTTGTTTATCAGCATATTTGGTCATTTTGGTACCATATACCCCTTTCCCCTGATTCCGAACAATGTGAAAAAATCGCTTCAAAAAACAAATCCCTGATTTATATTTACGCTTGAAATTGCGCCGAGTGATGTCAAATACGCGCGCATAAATAAATTCTCGACTTGGAGCGCGTTTGCCTCATTTAATTCCTTCTCCATATTTATTTTTACTTTTTTTTCAGTTTTTCACAGCTATTTTCATTCATTGTTATTGTATTTTATAGGTTTTTTTTATTGAAAAATAAATTTTTCCGTGTGAATTGAAACATTATTTGCATAAAAATGAATGAAAATAGCTGAAACACTGGTCCCAATAAAGTAAAAATATAAATGGAGGAAAATTAAATGAGGCGAACGTGCACCAAGGATAATTTAACGCCTTTGGGCGCGTAAAAAATCTCATGTAGTAGGCATGAAATTTAGGCGATTTCTAGCTTAATTATAACAGGGCGAAATTTTTTTTTTGATTTCATCGATATTCGAATCAGGGGAAAATTTGGAGACCTGTAACAAAAGTTGTGTTATGAAAAAAAAATGTATAATTTCTAAGGACAACTTTTTTTTTGTAGTTCTGATCACGCGAATATCACCTCAACGATTCGGCCGTCTGCTATCAGGGCAACGCGACAGGTGCTCCTAATTACATTCCCACACAGGTATTTTTCAGTGGAAAATTCACAAATTTTTCCACTACTTAAAATTCAAATTTCCTTTGCAGGATGACCCGCCCAAGAATGAATACAACAGGAATCTTCAGGAGACGCAGTCGTTGTCAATACAGATCGCCTATTTTTGTAGATGGGGGAAAACTAATTTTACAAAATTGAAAAAATCGTCGCCGAAAAGGTCTTGAGGGTTTTCGACGTTGGTGAACAGCGGTCCGAACGAAAAAGGTGGATTCATTGCCTCGAGGACGTGACGGCACTCATTTTCTGCGTTGCACATATGTCAGAATATGATATGGTTCTTGTCGAAGATTGGCAGTGCGATTTTCGAGTTTTTTGCTTTTTTTTCGTTTTTTTCCCAAGTTTAGGCTACCGTTTTTAGGTGAAAATCTCGGTTTTCTTGGTTAAAATGGTTTTTTTTTTGGCAAAAAACGCGCAAAAATTGAGGATTTTAGCGTGGCGTAAAATTGAGTTAATTACATGGAAAATTTCAGAAATTGAGTTAAAATTGTAGTTTAAGGATTTATTTTTGTGATTTTCTCGATTTTTGACCGTCGAAAACTGTTCGGAGTGAATTTCATTTATTACGCGCGACCACAAAATGCTGTGAGACCGCGTATTGCACAACATATTTGACGCGCAAAATATCTCGTAGCGAAAACTAAAGTAATTCTATAAATGACTACTGTAGCGCTCTGTCGATTTACGGAAATCGTGTAATCGATAAAGTATTTTGTTTAGAAAAAACACAAAAATGACAAAAAAATACGAAAATTGAATTGTTTCGAATAATCGGGTCCCGATCCCGTAAATCGACACAGTTGCCATTAAATTAAATGAAATTAATCATGTGTCGATTTACGGGACTCTCAATTGATATTCGAAACAATTCAATTTTCTTTCGTTTTTTTTTGTCATTTTTGTGTTTCTAAAAAAAGTTATACTTTATCGATTAATACACGATTTGCGTAAATCGACCCACAATGAGCTACACTAGTCATTTTCAGAACTACTGTAGTTTTCGCTACGAGATATAATTGCGCATCAAACATGTTGTGCATGACGGATTCTCAGCATCTGATTTTGTGGCAAGTCGCGCGTATTGAAAAGCTAAATAATCGATATTTTCTGATTTTTGCGCCGAATTTAATTTTTCTTGTTTTTTTTTCTGCGAAAACCACATTTTACTGACTAAATTCAGGTTCATCCATTTGTGCAAAAACTCCGTCGACGAAAGTGTATTTTAGCGTACTTTTAATTTTAAATTTTTTTCGCTCTGAAAATTATGAAAACAAAATTTTCTCGATTTTTGAACCGAATAAAACGTTCAAATTTCAATTTAAATCGAAATCGGGAAAAAATTTTCCGATTTTTACACCGATGATTATCGCTAATTTTTCCCACACCACATTTTTTGCGTTTCAGAATCGTATGCTAGAATCGCTAAAACTGTTGGACCGATTTGCAACAATAAATGGTTTGTCGAGAAGTCGATTATTCTATTTCTCAACAAAAAAGACTTATTCGAAGAGAACATCGTTAGAACTCCACTCATGCTTTCCGGAATATACGGGCGCCAATAATTACGAAGAATCTGGGTACATTCAACAACACTTTGAGGATAAATGAATAAGAGGACTCCTGCAGAGAAAGTTGGTGGTTTTTTTGAATTCACTGCACTTTTTCTCCTCACGAGGGGACGAGGAAAAGTGGTTTCTAGGTAATGGCCGAGAGGCCGACAAGTACTTTCCAGCAACATGGCCAGCGCATTTAATCTTCACGAGCTTTGTTTTCCGCCTGTTTGCGTCTTTTTTCATCGATTTTTTTCGTTTTTTCGTGAGTAAAACTGATAGAAAATAAGTATTTTTTGCCGATGCTAAAACAATTTCCCTCAAGTAAAAAGATCATGTATTCAGGCGGCAAGCCGGGTGAAATGGGCATTGTATGATGGATTACGGGAATACAAAACCTAAACTTTTTCTGAAACATGAAACATATGATGCTTAGATGCTGAAATTACTTGATTTTCATAACGAGCGGACCGGACCGCTGAAAAGTTTCGGGCTCAGGTTTCCACAAATCAACTTTTTGTGCGAAAAGCTAGACTTTTTCACCACAAAAAGTTGAATTTTGGAAACCTCAAAACTTTTCAGCAAGGCGGTCTCGTTATGAATATCAGGTAGTTTCAGGATTTAAGCAGCATATGTATCATGATTCGGAAAAAGTCTAGGTTTTGTATTGCGGTAATCCATCATATTGATTGCACATTGTTTCTCCGTAATCTGCTTGCCCACTGAATGCATAATTTTTTTACGTGGATATTGATTTAGCATCTGCAAAAAATATTTATTCATCAGTTTTATTAAAAACGAAAAAAATCTGACGAAAGCGGGAAAACAGGCGGAAAACAAAGCAAGATAAATGGCAAACTTGTCGGACCCTCGGCCATGGCGTAGAAACCACTTTTCCAAGTCGTCCCTCGTGAGGAAAACCATGTTGAAGTGAGCAAACTCAATTTTTGAATTTATTTTTCATGGAAATCGGAAAATCTTCAATTTTTCCTAATCAATGCCATCTCTACAGAATCAAGAAATCTACACCCAATTCATTACGTGCCACCGACACTAACAACATTCGATTCGTTTTCGATGCCGTCACCGACATTATCATTTATCGAGAAAACCTCCGCACGTGCGGGCTCAAATTTTTCCGCTAAATTTTTTCCGTTTATTCCCCCAATATCACCTCCGAGACATTTTCCAGTAATTATGTCACTGATTGCCACACACAGCCCTCCTCTCCCGTCTCCGCTGTGCAATGCTACGGATTCTCTTTTTTTTTCTTTTTTTTTCCTGAAATTCCAAGGGTGTCGTTGAAAATCGAAAAATTTGAAAAATTTGGGTTCTAAATTTTAGGAAAAGCCAAAAATACAATTTTTTTGATTATTATTCCGGAGAATTCGAAAAATTTCGATATTTTTTAAATTTTTTACAAAAAATTCGAACAATTGCGTTGGATTTTTTCAGGAAAAAGCCAAAAAATTACAATTTGTGTTTAACAAAACGAAAATAAACCAATTTTTCTGATTTCCGGAAAAATCAAAAAATCTCGATTATTTCCAGAAAAATTCGAATAATTTGGGGCTTTTTCAAAATAAATCTTAAAATTTGATTTTGTCCAGGAAAAATCGATAATTAACTGTTTTCTTTTTTGGCTTCTTCCGGAAAATCCAAAAATTTTGCATTTTTTGGATTTGTTTTCAGAATTAAAATTGGAAAATGGATTTTTCAGGAAAAAGCCTAACAATTTCAAAGCTTTAAAAAAACTTTAACAAATTGATTTTTGAGGAAACAACGAAAAATTTTCCGACATCTTACGTTGATTTTTTTTTTACCGAAAAACAAATTTATTTTTTCCAGGAAAAAGCGAAAAATTTTCAATTTTTAAGGAAAAACTCGAACAATTTAGCCTGATTTCGAGTTGATTTGCGTTTATTACGGAAAAATCGAAAGTAATTTTGGTTTTGAGCTTAGAGTGAAAACCCATAAGTTCAATTTATTTTTCAGAAATCCAATTATTTCAATTTTTGAATTTATTCAAAAAAAAAAAATGTCGATTTTTTCCAGAAAAATCGAAATTTTTCGTTTTTGAATGAAAAAAAAATTTTCCTTCAATTTTTCCTTTAAAAAAAATAAATAATGTTCGAATTTCCATGAAAAAAAGTCAAAAAAATTCAAAATTTTCCATTTTCCCTGAAAAGTCAAAATTTTCCGAGTTTCCTAAACTAAAATCCCAATATATTTTCCGGATTTTCCAATTTTCTCTGAAAAATCGAGGATTTTTTCCCGCACACCTTACCCTGCTGTTCACGTGGTGGTCAGGTTGTCTCATTTTGTGATCTACAAAAAATGAGGCCGGAATCTTTCCTCCCCCGGGAAAATCTGACGTCAGCGCACTCGTGTAACCATGCAATCCCCTGCTGATAAGTCTGCGTCTCTTCTCCCGCCGCATTTTTTGTAGTTCAACGTGTAGATCAATAATGAGACCTTGACACCACGTGCCGAAAGCCTAAACCAATATTTTACCGGTAGCTTCTGGCATCTCTACAACCACTGTCTGAAATATCGCGTCATTTTATATTATTATTATTTATTGTATTCGCTTGAACGGCCAAACAATTCCGCCATTTGATTCAAAAAGTAAACATTTCCGAACTTTTTAAAAATTTGAAAAATATTTTTAAAAAATTGTTAGCGTGAAAAACTTGTCCCCCCACCCTGCCTCTCCATAAAAATTAAGTTCGGAAGAATTCAGTCCTTGTTGTTGTAAATTGACGCAATGCGCTTTTTGGTGGTACCTATTTTGCATATTTATCGTCACTTGCGTACGCGAGGTATTGATTCAGATTCCGTCAGTTTTTTACAACAAAATATCGCTAAGCAATCACTCCAGCGCGAAACTTCAAAAGCGAGAAAGGCCAAAATGTTTTGCGTCGCTTTCTATGATTTTATGACGAAAAGCGAGGAAAGCTAATAAAAACAGCGAAAACTTTGCCAGGAAATTTACCGGTTTGCCGCTTTTTTTGCGCTAGAGCGCGATTGCTCACTGAGTTCAAGCGCCCTTCTTATTTTGAAATAGAAGAGTTTGCCGAATTAGGCTATTTTGGTGCGGCACGGCTGGGGTCAATTTACGGCGCGTTGCGTGCCGCGTCGCGGTAGGTGGACCACGCCTTTACCACGCGTAGACGATTGTCACTATAGAGCGCCGAAAATGTAAGGCCAGAAGCCGGTATGAGTGAACTTTTTGTTCATTATTTTTTTTTTCGTCGTTTTTAACGGTTTTTATGTTAAAATCAATAAAAACGGCGAAAATAATTAAGCAAACGATATTCCGGGTTTGGCGCTTGCTTTGCGCTAGAGCGCGGTTGGAGTGCTCACCGAGTTCAAACGGCGCACTCTGGCTTAACTACCCTATTTTGAAATGGAAGAGTTTATTAGGCCTATATTTTGTCCGGTCGGCGGGTAGATTTACGGGGCGTCGCGTGTCGCCCGCGGCTCGATTTTGATTGTAAAACTAAATGTATTTGTCCGTGAGGAGTACACGCGACTTTCCCAATGCCGCGTTGTCCAGCAGGTTATTGCCAATGGAGCGCCGAAAATGCAAGGCCAGAAGTCCGCCGTATAAGTAGCCCATGAATGAGTGAAGTTGTTGTACATTTTCAGTGCACTTTTTGTTTCGTCGTTTTTCTGGTTTTTATGTGAAAATCTGGCACAGTCTCCTGTCATCGAAAGCGCACAAAAAACTGCCTCGCGTTTGAGGTCGCGTTTTTGCTAGCGCATTTTGTGGATTTCTCCGAAATTCAGAAATTACGCGGCAAATGGCGAGGCTTGAATTCCAAATTACAGCCCCGCCTCTTTTGATACATTATCTTCAGGATGAAGATGATCGCTCCGAAAGGTGGGTGACTCTGAATGAAAATACAAGAAAATTATGATTTCTTCAGAGAAACACCATTTTCACCGTTCATTTTTTAATATCCCTACGCCTCCTTCATTTTTTGACCAAATTTTCTCTTTTAATGGTCTTTCATTTCATTTTGTGCTAATAAACAAATTAAGTTCGACATCTGCGAAAAAATTCGTTCAACGCTAAAAAACGACGAAGTTTTTTTTTCAACACTAAAAAGAATATTCACTCCTAGCTCCGCCGGCTGTACCAATGTGCAAGTGCGCCCCAGCCCACTTCGACGCCGAGGAGACTGCGAAATCATTAAAAACAGTGAAAATAACGGAAATTCTGAAATTCCGGGTTTCGTTTGATAATTTTTTGCGCTGGAGCGACTACGATTGCTCACCGTTAAAATAGCGCACGCGCTTCTGGTTTCCCCCATAAATTGAAATGGAAGAGAGTTTTCGCCGAATTAGGTCATTTTGGCGCGGCCCCGACCGGGGTAGATTTACGGCGCGCTACGTGTCGCGTCGCGGATCGATTTTAGGTGTCAAACTAAATGTAGTTGTCCGTGTGGAGGGGGATACACGACTTACACTCCCGTCCGGCAGGCGATTGCAAGTGGAGCGCGAAAATGCGAGGCCAGAAGCCCGTATATGCATTTTTTTGCTGAGGGTCCCGCCACGACATTTACCCTTTCAGTCACGTGTATCAAAGAGGACCGGGCAATTTGGTCAGAAGGAAAATGAGAACTCGCCACGCCAATCAAGTTCTTTTTATCGATGACGGACAATTGCCAAAGGAGGGAAACTCATCTCGTAAGAAAGGGAATTCTTATGAGCTTCGGAAAATCGATTGAAGTATCTGACAAACGGATATGAGACTGTGAGACTTTTTTTAATACTATTGGGTCTCGACGCGATTTCCCACGGATTTCGGGCTTCCCTCATAAATTGAAATGGAAGAGCGTTTACTTGCCGAGGAACTAGGCCCAGGCCATATCTGGGGTAGATTGCTACGGGCGTTCCTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAACTGAAGGTATATCGTCCGTGTGGAGTACACGGGCGCTTGCCAATGGAGCGCGCTAAAAATTCAATTTGTGTCTCGCTTTTAACGATTTTATCGATTCTTGGGTGCTGTTCGAACAAGCTCTGAGTCGTGTCACTTGAATTCAATACGGAACACTTTCTTGTGATCAATTTTTGGATGAGAAGCTACTATTTCATGACAAACGGTGAAAATACCAGCTGTCATACACCGAAACCAACCATCAAACCCGAATTGAATCACTTTATTCGGTTAGCAGGAGAATATCGCTCCATCGCAACCATGTTTTCAGCGAATACTTCATCCAACTGCGGCCCCTCCAGCGAACAGTCAAAGAGAAACCTGCGTTGATCATGTTTGGGGATCAGTCGAAACCGCGAGTTTTAAAGTCGAAATAATCGAAGAGGGAGAGCAGCGCTGAAAGAGAATTCGGGGAAGAAGTGCTGAAAAAGTTCCAGAAAATTCGGACTGAAAGGTTAGAGCGGCGGCGGTGAATAACTCGACGGAGTGGACACAGACGGTGAAGGATACTCGGAGACTAAAACATCGTAGCGAGTGAGTTTGTGCCAAACGCTACTCAGATGTACTTCCGCTTCCGTGAGGACACCGCGTTTGATCTCTGAAAATTGCGAGAGTCAGCCCCTTCGTGTAAGTTTCCCGCAATATTTGAAGGTTAAGCAGCGAGGTCCTCATATTTTGAAGAAAGAACTTTATTGCCGTCTAATTCGGAGTCGATTTACGGCGCGTTGCGTTGCTTGTCGCGTCGCGTCTCGTGATTCGCATATTTATCGACACTCGCGTACGCCACGTATCAGATTCCGTGAGTTTTTGCAACAAAAAAATCGCATATGAGCAATCGCGCTCCACTGGAAAACACCCGAAAAGTTTTGAAATTGGGGTTGTCGCTTGTTTTGCGCGCTAGAGCGCGATTGCTCGCCGAGGTTTCAAACGACACTCTCTGGTTTCCCCCTTGTAGACGAGCGTCGCGGTTCGGTCCAGCAGGCGATTGTGAGCGCGAAAAACACGTGGTGTCAACAGTGTCCCATTATGGTTTGATCTTTGATAAATGTGTACGGGAGACGACAGACACCGACTTCTCAACTGATTTCGCGGCAATGGTTAAAAGTGTTCTGACGTCACATTTTTCTGGCATTCAAGACGCGAAAAACTCCCGTATTTTTTGTAAATCAAACCGGATTAGGACAGCCGAACGTGGAAAAAAGGCAAGATGACAAGGGCCCAAAGGTGACCCACAGAAGCCCGGCAGAGTCTCGGTTTTATCAGTTTTCGAGTAGTTTCGCACCACAAAAAGCGTGTGACGTCACATTTCCGGCCGCAAAATTCCCGCGCTTTTTGAAGATCAAACCGGAATGCATTGTTTCAGAATCTACTCTTTGTCTCTCGTTCATTCACCTCGGTTTGGGTATGGTATTGATCGTAACGCTATCGTTTTTTTGTTCTTTTTCAAGTATTTCAAGAAGTTCAACTCGACGGTGAAGAATGGAGATCAGGTGTATAGAGAGCAGGAATCGGCTGAGACTGATGAGAAGACTGAGAAGACTGAGAAGCGCGAAAAACTTTCTATCTGCGTGTGTCACTGCAAATAAAGAAAGGAATTGAAAATAAAAAAAAAAAAAATTTTTTGGGAGTTGCATATATGCATGTGTCGTGGTGTCCGAGTGGATTATTTCGGTTTGATCTACGTTGATAATCTCTCCAAAAAATGCGGGCACTGATTTTGCATGGATAAGAACGTGCTGACGTCACATATTTTTGTGGGCGAATATTCCGGCATTTTTTGTAGATCAAACCGTGATGGGACACGGTCTGGCATCACGTGTACTTGTCGCAATAAATGAGGTACAACATGTTATGCCGTTATCCTACAGTACTATAGGTGAACCCCGCACTTTTTGGCCTCCAAAAATTGGATGTTATAGGTCACAAACTTGTAAGGAGTCGTGGACATGAATGTCAAGATTCAAATTATTCAAGTCAAAAGGATGATAGCGCAGACACGTGCCCCCAACTTCGGTTTTCTACTGTGTAGATCAACAAAATGCGGGATTTAGGACGCTGAGTTCTCCACTGATTTTGCAACAAATTCCCGGAGCTTTTTTGAAGATCAAACCGGACAACCTGACACCAGGTGAAGGAATAAAACACGCTCTTTTGCCGAAATCTTAAGAGTTTCTACAATTTGAAAATCCAGTATTAGATTTTCTGAAAAAAAGTCCAAAGTTAAATAATGGACGCTGCCTAGTCTTTGGGTCCTCCTCTAAAAACGCCCTTTACAAAAAAAATCTATAGTTTCTGAAAAATAAGTGGCAAATCTCTACAATTTTCAATATTTCATACTAAAAAAATCACAAAAAATTATTTTATGGCCGCGCTCGAGTTTTTTACTCTTCCTCGTGGTGTCAGAGTGTCCAATTGCGGTTTGATCGACCGTGTAGATCTAAATTCGGGATTCGAGAACTGAATTTGCATGATTGCTGACTTCACATTGTTTTGGGTAAAACTAATTTCGGCATTTTTAGTAGATCAAAAAAGCCTGGCACCGCGTGCGCAGAGAAGAAAGAGCTAATGAGCACGGGGTGTCAGGAACGGCTTGATCTACAAAACTTGCGGGAGTTTTCAACCCAAAAATATGTGACGTCAGCGCGTGCTTAACCATGAAGAATCAGTTTCAACTCCCGCAATTTTTGGATATCTAGGATCATAGATGAAACCGAAATGGGACACTCTGAAACCCCGGGAATGAGCCAATTGAGCAAAAGTATGCGAACTGAAGGAGGCATCGTTTTATTCGCGCAGAGGTTAGTTAGACGAATTGAATAGGCAAGAAAAAATAATGTTTTGCAACATAAAAGTAATGTACATACTAATGGAAATAAATTAATTATGGGGGAGCTTCATTATTACAAGTCGACGAAGAGCAGCACTCGTTCTTCTCCTCCTTTTCCTTCTCTTTTTCGTTTGGAACGGAGAATTCGACTGGGGTTTCCACATTAGACGGGAGCTGGAGCATCTGAAAAAAAAACGCGAAAAATGGTAGACTTGTCACACGTTTTCCAACCTACTACCTTCTCAAAATAAGACTGGAGAAGAGCGGTAGTACACTTGAGCATGTTCTTCAACAGTAGCGACTCGTAGTTTTCGATCGATTCCTGGAACTTTTGGATCCACACACCGCTCCTTGTCCGCCCTGTCGGCGACATGTAGGGTGTAGATGCCCACGACCTTGGTAGTAGCGGGTTTGGTGAATTATGACGAACGCGAATCTTAGGGACGGATTACTAGAAGAGAAACACACTTATAGTGACAATACAGTAGTCCTAGAAGGTATTGGTAAGGTACTGAGGTACTGACTGCGCTAATTTTTGTACGTTACACCTTTTCCTGGAGTTTTGCAGACCTTCAAGAAAATTCTAGCACTTCCCATTTTCTCCGAAAAATTCCTGCACTTTCCAGATTTTACCAGAGAATTCCCGCACTATACAGATTTTTCTAGAAAATTTTGTTTTTCTCAGAGTTTTACGGCTCCTATAACTACAGTAACCCTACAGTACCCCCCAGACCATATCGCCCCTACCCCAACATACAACCCAATACATCAAAAGACAAAAACTCAAATTTTCCGGAACGTAACCCTATAACTCCTTTAACGTAGACCTACCGGGCCCCTACAGCACTGCTGCAGGACCTTGAGACATAACCCCCTACCAACATACAAATACCTCTTCGAAAGCTGGGAACTCAAATTTTCTATACAGTAATCCCGCTACAGTACTTCTACAGTACCTCCAGTACTACTACAGTACACCGACCATATCCCCCACAAACGCTATACAAATTTTCCTTCAAAAGACAAAAACTCAAATTTTCCCAAACTACAGTAAGCCTAAGCAGTACTCCTACAGTCAGATCCCCGACCTTCCGATATATCCCCACACCAACATACAGCCCAATGTTCCTTCAAAAAACAGAAAAAACTAAAATTTTCCAAAACTACAGTAACCCTACAGTACTCTTACAGCTAACCTCTACAGTACTCCTACAGTACCTGGACATCATCCTTCACCACTTCCAATCTAATACCTCTTTAAAAGCTGAAAATTCGAATATCCTATAACTACAGTAGTTCTACCAGTACTCCTACCTCTACAGTACCACTACATTACCCCCAGTACCCCTACCACATCCCCCCATCTCTAAACCAATATCCCTTCATAAGCACACTACAAAGACTACGTGGACTACAAACTATGTATGGTCAGACGGTTTATTTTTAATATGAGAAATGATGATGAACTAGCTGATATATACTACTATATGTACTGACACTGATTCACCAAAATTAGCGTGTCAATTCAAGATAGGGGTCTTTACGGTACTGGTATGGTACTGGTCCGATACTAGCCCCAGTTCTTTAATACGATTCCCTAAAATTGCTGACTCGGCGTTCCTGGTCGTTGGAGTCCGCATCACTCTGACGCAAAAATCCATACCTCGTTCGGTAATACGATCCGGCGCTCAGATTTCCCGATTGGGACTGGATCCTTTCTGCAACTCTTTGTCTTCAGTAATAAAACATGGAGAGTAATAAAACTTCGCGGGACTCCTCACCACTTTAAGCTTCGAAGGGCACTTTTTAGTTTTAGTCAGCACAAACATGTCGTTCAATAGAAACGCGTACATGTCAACGGTCCGCCCGTTTTCCACAAGCTCGAGGGGGCGATCTTCGTGGATAAGCTCTCGACGCGGATGAGCCAGTAGGTTCTCGCAGAATTGACGGATGAGGCGACGCGGAGGAACTGGTAAAAAATCAAGGGAAAATGTTGCGGGGAAAACAAATGTTTCAACTTTCATCATGGACATAAGACTTGGCAAGTCGCTTATATTCGGCCAGACCCCAAACCTGTGTCTGCAACTGCTGAAGCCTCTCAATTATGAAGGCGCCACTGCACACTATAATCAATCGATCGGTGGCCAGTGTTCCGTCATTGTGTCGATCATTCTCCACCTTTCCCTTACTCGCCTCTTCCTCCGATCTTTTGTGAATCTCGCGGAGAAGGATCGGAAGCCGAGTGATCGTCGTTGGGTGCGTCAAAAGATCCTCGAGCCGTACACGGAAGCATCGTTCATCGGCCAGACTTTATCCGCTCGAATTCCGTGAATCGTTCCTCTTTCTGTCGCATTGAGCCGAAATATTCCATGGTTGCGTAGTTGATGCAGTAGGCTTGGTAGGCGAAATTGTGGAAGGGCGTTTGCAGAACTGGAAGTTTCGCGTTATAACAAGGCATAGTCTCAAGCTATTTTCTCTGCAGCCTATCCCAGCTGTGGTCCTGGTGCTTAACAGTCGTGATTTCTGCTGGAAAACCGGTCTAATCCGGACTACGGAAGCCTGTGTTTTTGAGTCTAAACGACAACATTGTGAGCGGCAACCAGGTACGCTTTTTCATACTACTTTTTTTTAAACTGTTTTTTTGTTCTTTTTCGGCCAGCGGAAGTTTTTGACCCAACTTCGAAATGTCCCTTTTTTTCGCACTTGAGTTTGGGAATTTCTAGAAACTTCCCAGTATTTTCTCTTTTTCCCGCGAAGCCCCTTCTAAACCTGGGCCTAGGCCTACGCATAAACCTAAGCCTACGCCAAAACCTACGTAGCCTAAGCCTAAAAAGCCTAAGCTTAAGCCTAAGCCTAAGCCTAACCTAAGCCTAAGCCTAAGCCTAAGCCTTAGCTTAAGCAGCCGAATGCCTAAGCGTAGGCCTAAGACTGAGACTATGCCTAAGTCCCAGCCTTTACCCAAGCCTAGGGCTAGTTGAAATCCTAAAGCCTAACCCAAACCCTAAGCCGATAATTGCCTAAGCGTAAGTCCAACATACTTAGGCCTAAGCATTAAGCCTAACAAGCATGTCCCTTTTTCTGGCAATTTTAGGAATTTCTAGAAATTTCACATTTTCTCTTTTTCCAGCCCCTTCTAAACCTAGGCCTAGGCCGCATCAACCTGAGCCTACGCCTAAACCTAAGCCTAAGCCTAAGCCTAAGTCTAAGCCTAAGCAGCCTCAGCCTAAGCCTAAGCCTAAGTCTAAGCCTAAGCTTAAACCTGAGCCCAAGCCTAAGCCTAGGCCTAAGACTAAGCTTATGCCTGTTCCTAGCGAAGCCTTAACCCAAGCCTAGAAGGGGGCTAGTTGAAAGCCTAAGCCTAACCCAAAACCCTAAGCCTAAGCCTAAGCCTAAGTCTACGACTAAGCATATGTCTAAGCCTAAGTCTAAACCGAAGCCTAAGCCGAATCCCAAGCCTAAGCCTAAGCCTACGCCGACGGAGCACGAGGAGAAAGTACATAACTTTGTCACAAAAACAAACATTTCTCAATATCGGTCAGTTTTCAAAAATATTTCGGGTAATTTCTCAGGACAAATAACAAAAACCCACCCTTTCATACAAGTCCACAACTAGCTGTGTGCCAATTCTCCTTGTCTACCGGACTGAGCAACGAGAGGAACGATTGACAGAAGGCGAGTATTCTGACAAAATAAAAATGTGTGTGTGTGTGTGAAATGGCACGTCAGATTAAAGGGAAATAGAAAAAAAAAATTAAAACTGAAGGAACCTGCAGAGTTGATCCAAATTTCGGAAAAGGAGGGTCCGGCTCGACAAGAGTAGACATCCCTGTTCGACTTGACATCTCTTCAGCGTCCTTGTAAACATCGCGGAGCACGAAGAGCTGACGATAGAGGAAGACGAGCCGTGTGGAACAGCTCCCATAGCTTGAAGTTATGTGTGTCTGGATGTGGGAATTGTCGTGGTCTCGTCTCACATGAACATTTCCTCAAAGGATACTGGCTGAAAGTTGGATTTTTTTTTGGAATTGGAGCGCGTTTATGGGCTCGTTTTGCAGTTTGTTTATACCCTTAGACATTAAAAAGACATCAGCAACAAAGTCCCACAAGTAGTAAACAAGAGAGATTTTCTCTAACACGAAAATGTGAGAGAGGAATTTTTATTCGAAGCACCATGTTTCTCACTCAAATTTGACTACTCATAACTTAGGTAAACTTAATCCAATACTTCCTTAATAGCTAAAAATTCACATATTCCAACAAACTACAGTAAACTACAGGTACCCTACCGTACCCCTACAGTACCCCGACAGTACCCATACAGTACTTTGACAATATCACCAATCCACTCCCTACAAAATCATCAAAAACAAAAAATTCACAATTTTCAAACAGTAAGTACCCTAGAGTGATCCTATAGTATTCCTACAGTACCACTACATTACCTTGACATATCCCCCTAAACCAATTTCCACCCCCAGGAAGCAATACCCCTTCTAAAACTAAAATACCCATTTCCCAAAACTACAGTAACCCTACCGTACTAGTACCTGCAGTACCACTACAGTACCATTAACCTTGACATTATCCCCCTCAACTTCCAATTAAATACCACTTCAGAAGCTAAAAAATCAAATTTTCCCGAACTAAAGTATCCCTACCGTATAACTACAGTACCCTACAGTGCCACTACAGTACCTTGACATTATCCCCCTCCAACTTCCAACCCAATACTCAATCAAACGCTAAAAATTAACATTTTCCCAAACTACAGTAACCTTACCGTATTCCTACAGTACCCCTATAGTTTCACCTACCAACAACTTTTCCAGCTCATGATCCTCAATCTCATGATCCTTGAAGTCTCCAACGGCCTGAACATGCTTAAGAATCTCACTCCGTTTTGCTCGCTGCACCACTCGTAACGTCTCTTCAGTATCCAGGGCGATCGATTTTTCTGGGGCTGACACAAGCTACTGGATAGAAGGCTCGAAAGGCTATTGTGGCACGTCGGGTGAAGATCTGAAAATGAAGAATCGGTGGGGATCCGTGGTGTCAGCGAGGGAGAAGATCTATTTGGTGGGGTGGCATATAGAAGTGGGTAGTAGCGGTTTCTTCGTTTGTGTGATCTTTGTGTCAATAGACATGATATTAGGGCTTCGGTGGTAGGCAGGTGCGGTTTTAGGGCCTGGCTCTTGCCTGACGCCTGCCCTTCTCACGCCTGCCTGGCGCCTTTTATCATTTTGAGACAGTGAGTATAGGTTTCAAACTTCAAATTTTCTCATTTCTATCATTTTGTTGAAAATCAAATTAAGAAATGAAAAAAAAGTTTAAGTAGTTGCATTAGGCGTGTATTTAGGAATTGCGAGAGGCAGGCGGGGGTCGTCAAGTCAGGCAGGCAGGTCTTCTTATGCCTACACCTCCGGAAGGTGTTCAAAAATCGGTTGCGGGTGTCCAGCAGTAACTTGACAAGAATCATACAAAGCATTCGACTTTTACACAAACCTGACTAGGCTGTGTATTCCACCTGTACAAACACCTAACGATCGATGTACCTGATTTTATTTGATCTGAAAAAAAAATTTCTCAGAAAATTTGAATTCAAAATGTTTCTTTGAAAGTTTGAATTCCCTGCCAAAAACATTCTCAGAAAATTCAGGTTCGCCAAAATTGTTTCAGATTTGAAAATTTAAATTCCCGCCAAAATTTTTCTGTGAAAATTTGAACTCTCGCCAAAATGTTTTTTGTGAAGAAATTTGAATTCCGATACACAAATTTTTACAGAGCATTTGAATTTCCCCCTACAATTTTCACAGATCTTCTTATATATACATATATATATATATATATTAGTTGAACTTTTGGGCAGTTTTCAAAAAAAAAGTCCGGTGATTTATTTAAGCACGTGGTGGCAAAAAATAATTTTTCGGCTTGATCTACGCCGATCTACTAAAAATGCGGGAGACGCAGAGTTCTCAGTTGATTTCTCAAGGTTAAGAAAATTCCGGCATTTTGTACGATATCAAACCGTAATGGGACAGCCTGGCAGATTACCACGTGCTAAAGTTATAGTTAATTTACAAGTCCTGGTTGCAGTGGACCTGCAGGATGTCATGAAGTAGCACGTGTTTTCTGGAAAAAGTTGGTAAACTTTCATACGAAGAGGAAAGTGTAATCGATATTTACTTGACCATTTTTTTGCTAAAAAGTAAGAGTCTTTGAGCCAGGCCGGCGATCGGTAATTGCCGAAAATCGGCAATTTCGGCAATTGCCGGTTTAGTGCAAAGAATTTTTTGGCAATCGCCAATTGTGGCAATTGCCGAAATTGCCAAAAATTCGATTCCGCACACTCCTGCTTTGAACTGTGAATTTCCAAAATCCAATCGAAATTCTGCCGACACTGTACAATCCCTACCTGCCAACAATCCGCCGGAGCTGATTGCCCAAATTTATTGAGGTGACTCTCGTTAGGGGATAGATTTGATCATGTGGGACAATGAGGTCACATTGTCGAGCAGCACCCTTCGGATGAGGTCTCCTGATTCTCACTTGGCTGATCAGGAATGATTGCATGGCGTCGGGAAGGTTGCCTTATTAGGGTGACTTGTTTGGGCTCTCCTTCTTCTGGCTGGAAAAATACAATTTTTTGAAGTTAAGATTTGAAAAAGAAAGCTGTCATTTTTTTGTTGGTATTTTTTACCCTAAAAATGTGGTTTCAAAATATTTTTACATCTGAATATCTATTCAACGGGGTGAACAACTGCAGATCGACCATACTCGAGCTTCTAAAAGTTTGAAGGACGCTTCTCGTGAAGAAAAGAAAAGAAACACGATATAGTTACCCCTACATCGGAAGAGGATGGGATATACTGAGAAGTAAGAATAGGAAGAGAAATGAGAAGAGTTCATATGCACTAGAGAAGTATGTACAATATAATAATTTATGAGCATCTGAGAAAATGAGAGCTATTTGAAAATCTGCAGAGCAAGATAAAACTCGGTCTCTTATCAGAAAATTTGAAATCCCGCCAAAATGTTTATTGTTTAATTTGACGCCAAAACTTTTCACAACGAATTTGATTTCGCCAAAATTTTTCTCAGAGATTTTGAATTTTCCCGCCAAAAGATTTACCAGAAAATTAAAATTCCCGCCAAAACTCTTCACCTCGAATTTGAATAACCCGTTTTTTCTCAGACAGTTTGACCGCCAAAATTTTTCACATGAATTGAATCTTTCGCCAAAGATTAAAATCGTTGGATAATTTTCATTCGCGGCTGGTTTCCAAATCGAATTAAGAACGGCCAAAGTTTATCGGGGTTTTTTTTAACACTTACTACGAAAAAAAGCATGATATACATTTATTTTCCTAACGACGCCTGGTAAAATCCGCTTTACACATCAAAAACTTCTCGGCAACATTGCGTCACCGCCAAAAGAGATGCTTGCACTTCACCACGAATAATAGCTATGACAAGGCAATGCGTGTAGGGAGTTGAGAATTACAACTAATTCATATCCCCTGAAAAAATAAAAGCGCTGTTGTCTATATGATTCTTTACATGGTGACAGCTTACCGAAGAATAGACGGGTAATGAGATATATATGTGATTCATAAATATGGGCCTGCTCCCGGGTATCCGAGAGCCGAGTCGAAACAGAAGGGGAGCATGAATGGAGCAACTAGGGAAAATTGTGTTATCACGATGAGGCACGGCGGGGGACACAATAGATTTTTTTTTTGTCGAAAACGTTTTCCATTTTCACGTGGTTGGCGCATTACGATTTGAGCTACCAAAAACGCGGGAATTTTTCCCCTAAAAAAATGTATCGTCAGCACGTTGTTTACCATGAGAAATCAGTTGAGAAACTTGTTAGCGTCTCTTCTCCCGCATTTTTTGTAGCTCTAACTTGATCAAGCCGAAATGAGACGCTCTGACACCACGTGACGAAAAAAAGTAGATCAAAATTTGCCAAGCCCTTATAATACTCCCTTTTTCAGATCTAGGCGGAGCTCAGTTTGACTCTGATGACGTTAACGCAAATCTTGAAATTTCGAATTCTCTATGGAGATTAGAACTTCCCGCCCCCGCCAGACTTTGTAAAGTTCAACATAAAGATGAAATATAGAAAAAGTTCAGACTATGATAAGGAACTTATGACTAACGGCTCTTGAGGTGAATGAGTATGATGTGATTAGTGATGCAAGAGGTGCCGACTAGAGAGAGAGCTAGAGCGACGAGAGGCTCAGAGAGGGGGGAAACGGGAAGGTAGGTTTGTAGGTAGGCAAGGTAGGCAAATAGGGGGTCGGTATCCGAGAAATAAGGAACCTAGGTCGGCAGCCGTAGGCATAAAGTAGGTCAACATCCAAGTAAGTTAGACAGGTACGCAAAGATAGGAAGGTAAGTAGCCGCGGTGGCAAGGAGACTAAAGGAGTAGGACAGGAATACGTAGGCGCAGTAGGCAGACGATGAAGGTAGGTGGGTAAGCTTGTGAGAAGGCAGTCATAAAGAACGTCGACAGTAGATGCACTTAGTAGGTAGGTATGAAAAAAGAATTAAGGTATGCATAAGGAAGTAAAGTATGAATGGATGCAGCCGAACATGTAGATACAGAAATATCAGGCAAGTAGGAAACAGGCAGGCTCATAATATAGGAAAGTTAGCATCGTAGGCAAGTATGTAGTCCTGGGTAGGCATGTAGGTAGACACGTGGTAGGCTTATGGTTCGATATGCAAAAGAGCAAGCAATCATCAGAAATATGCATATTGGCAAGTATGTAGGCACGTGCATAAGATACAAAAGTAGACCAGGCATGTAAGTAGGCACGTAGGTAGGGAGGCTTGAGGCAGCAATGTAGGAGATCTGGTAAGTAGGTATGAGTATAAGTAACCTAGTGGTGGTAAGTCACAGGTATTTGGCACAATCCTGTGGTCACTGTTCTCAATGGTAATCAGGCGAACGTGCCTGCCTGCCTCCTTAGAAATTCGGTAAAAAGATTGTGGAAAAACAACTAGGGGAATTCCCATCCATGGAGTCCAATGCGTAATGTGAGTGGGAGGCGGCAAAAAAAAAGCGGACGTAAACACTTTTTCCTAATTCTCTTATACTCTCGCTCGTGGAAAATGTGAATATTTGATACAATTTTGTGGGAAAGTACAGCGAGCAGAAGAAGAAGCTGATGTCCCGATCGCGCGCGCGCGAAAAAAACTTTCAATTCCCACTCCCCTAATAATCCGCCTAACGCCTAATGTTTGTCAAATTCACCATGTATCGTTTTCTCACCCATCGGCTATGATTGTTTTTTTTTCTTTTTCAGCAAAAAAAACGGGCACATGAGGTCGGGATGGATAATTAGGGATGTGTGCCAATTTGGCTGATAGACAAAAAAGGAGTACGTGAGATTTTTAGAAAAGGTTGTTGAGAAAATTATCATGAGGCGTTGGGCACGTGGCCGCGAATGAGAAAACTAGGCTACCTTCACGGGGCCCCCATGGCCTTTCTCGTTGGAAAACTTTTCGCGATCTACTGACAAACGCCCGTGTTCCACACGGACAAATTCATTTAGTTTTGCAGCTAGAATCGATCAGCAACGCGACACGCAACGCGTCGACTAAATCTACCCCGAAGATATGGCCGCTCTTTAAAATGGCCTTGTTGGGCAAACTCTTCCATTTCAAATTTTTTATCGCCCTCAGTTTAATTTTTTAGGATACGCCTACGAGTGATCTAGGCCAGGCAGTAGGTAGGAGTGTAGGTAGCCCCCTTTTGGTGTCAGGCTGTCACATCGCGGTTTGATCTATCAAAAATATTGGTTCTCCCAGTAGAATGTGAAGTGAGCACGTTCTTAATCACGCGAAATCAGTTGATAAGTCTGCGTCTCAACCCGCTCCCGCATTTTTTGTAGATCAAGCGACGTAGATAAATACGAAATCAGACACTCTCGTGGTGGCAGAGCTGTCCCAACGCGGTTTGATCTACTAAAAACGCGGGAACATGTGCCCAAAATTATGAGACGTCAGCACGTTCTTAATCAGGGAAATCAGTTGAAAATAAAGTCTGCGTCTCTTCTCCCGCATTGTAGATCAAAGTAGACCACATTAAGACCTTCTGACACCATCCCCGAGAAGAGTTCAATATAACTTAGCTCGTAGAACATAAATTTTTCCACGTGGATTTTACAGCACAATTGCTTAGAGCCACTAGCGCGGTTGCCCAAATTTTACAGGAAAATGAATATTCAGGAAAATTTTACCAGATTTCCCGCGCAAGACACGAAAGTCTTAAAAAGTAGGAGAGCATGAAACTAAGAAAGTAAGAAACTTCTGGTTTACCACATAAATCAAATTGGAGATAGTCGACCTTAAAAATTTTGCACCAAACAGGGCGGAGCCAAAAACACCAAAAGTTACGCAAATTTGTACATGAAAACTAAACACCTAAAACCGGAGGACAAATATGAAGAAAAACGCTGAAAATGCGCAATGAGACTTTTTCCTCCGTTGCTTAATTTAATACATGTCCTCTCCCCCTTCCTTCCTGCTTTCACACTCTTTCGGCGTCGCCTCCTTTTGATTAGAGACCTGAGACTTTTTTTTTTGTGATTGCGTTGAGTAGTGTGGGATGCATATATTAAATCAAAAATCTGACATCAAAAATATCCCTGAAAAAAAACGTAGTTAAAATTTGCTTTAAAACTGCCGATGCGTTTGCTATTTGATCTACAGGGTGCTTTGGCGCGTTCGCGTCGCGGTTTGGAGTTCGAGGCGACGGCCATTCAATTTGACCCTACTACAATAGAAATATTTTGTAATCTTAGGCCATCAAAAATTTTTAAAAAACAAAACCGGAAATTTCTAGGCCATCAAGAATCTCTAGGCCACATCAGACTACTTTGAAAATTTGTAGGCCACAATGGGAACTATTTTCTGAACCAAATTTCTGAAATTTCTTGGCCACGATCTGAAATTTCGAAGCCATATAAAGATTTGTTTATAGGCCACGATCTGAAATGCGGATTCTAGACTACATCAACAAATCCTAGGCCACGATACTAGGCCACTATTTGAAATTTGTAGGTCAAGGTTTGAAATTTCTAAGCCACGATTAGAAATTTCTAGGCCACGATCTGAAATTTTTAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAATTTATTAGGCCACGATCTGAAGTTTTGGTCATCAAAATTTCTAGGCCATTTGAAATTTCTAGGCCACGATCTGAAATTTGCCACGGTTTGAAATTTCTAGGCCACGCTTTGAAATTTTTAGGCCACAATCTATTTCTAGGCCATCAAAAATTCATAGGCCACGATTTGAAATTTCTATCTGGCCACGATTTGAAATTCTGGGCCACGAACTGAAATTTCTAGGTCATCAAAAATTTCTTTTAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCGCGATCTGAAATTTCTAAGCCATCAAAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCGCGATCTGAAATTTCTAAGCCATCAAAAATTTCTTTAGGCCACATTTTAAATTTATTGTTTAAAATTATAGGTTTTCAAAAAAATTCTAGGCCATCAAAACTTTCTGCAGGGATTTGAAATTTCTAGTAGCCACGATCTGAAATTTCTAGGCCACGATTTGAATTTTCTAGGCCACGATTTGAAATTTTTAGACCACGATCTGAAATTTCTAGGCCCTCCAAAATTTATAGGCCACGATTTGAAATTTCCAGGCCCCGATTTGGAATTTCTGGGCCACGATCTGAACTGATTTCTAGTCATAAAAATTTCTAGGCCACGGATTTGACATTTCTAGGCCACGATTTGAAGTTTCTGGGCCGCTAAATTTCTAAGCCATCAAAAATTTCTAGGCCACGTTTTAAACTTTTTAAAATGTTTAAAATTGTTGGTTTTCAAAAAAATTCTAGGCCATCAAAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCCCGAATCTTTCTAGACGATTTGAAATTTCTAGGCCACGATTTGAAATTTTTAGGCCACGATCCGAAATTTCTCCAAGGCCATCAATTTATTGGCCACGATTTGAAATTTCTGATCGAGGCCACGATTGAAATTTTTAGGCCACGATATGTAATTTTTAGGTCCTCAAAAATTTATAGGCCACGATTTGAAATTTCTAGACCACGATTTGAAATTTCTAGGCCACGATTTGAAATTTCTGGGCCACGATCTGATTTAGGTCATCAAAAATTTCTAGGCCACGATTTGTAATTTCTAGGATTTGAAATTTCTAGGCCGCGATCAGAAATTTCTAAGCCATCAAAATTTCTAGGCGGCCCACGTTTTAAAATTTTTATTCAAAACATTTATAGGTTTACTTCAAAAAAATTCCTTAGACGGCCATCAAAAATTTCTAGGCCTACGATTTGAAATTTCTAGGGTGACAACGATTTGAAATTTTAAAGCCACGATCTGAAATTTCTAGGCCATTAAATTTATAAGCAGGCCACGATTTGAAATTTCTAGGGCACGATTTGAAATTTCTGGGCCACGAAAGATTTATAGGTCATCAAAAATTTCTAGGACAGGATTTGAGAATTGCTAGTCCAGGATTTACAACGAAATTTCTAGTCCGCGTATTATCAGTCGAAATTTCTAAGCCATCAAAAATTTCAGGCTCACGATTTGCGCGAAATGTCTAGGCCACGATCTATTTGAAATTCCGTGTTTAGGCGATTTCAAATTTCTTGGCCACGATTTGAAATCTAATTTATAGCCCGTGATTTGTAAGTTCTAGGTCATCAAAAGGCGATTTCTAGGCCAGGATTACTCTAAAATTTCTAGTCCATCAATATTTCTAGCACAAAATTTGTGTTCACTTTTTTTTTTGTTTTGGTATGTATTTTTCAGAACTTATTCAAAATTTGTGGGAGCAACAATATGCTTTTTTAATTTCTACGCCACAAAATTCTTTGGCCTTTTTCACTTTTTTTCACGCCGCCTATGGTTCCACTGGATAATTGAATGTAGAGAAAAAAGGGAAGGGTTCAGCTAGCGCAAAATAATTCGTTGGAAGGGAAAAAAATAAATGCAAATCTTCGCCAAAAACCAATTTTAGGTCGGAGCTCGGCGCGGGTTCGCACACACACAAAAATGGAGCAGAAGATGACGTCAGATCTTCTTTTTCAGAAGGCTTTCTCAAACTTTGAAAATGGCCAATTTCTTGCTGCTAATTGTGGGATGGGGACAGAATGATATTTTGTTTCAGGTTTCACACCACATCAGATCCTAGTCTTATTTTTTTCTTTTCTCAGGAGTACACACACTATAAATTGTGGTAAAAAAAAGAACACGTCCAGACTTGCTTATTTTATACCGATTTGATGCGGCCTACACAAAACGCGGGAGTTAAAAAGCAACTCGACATCTCACCTGATTTCGCAAGAGCGTGCTCTAGACCAACCGCCACAATTTTTTTGGAAAAATATTTCCGCATTTCTTGTAGATCAAACTTAAGACACCCGCACCGCGTCACAAATAGTATTCCTCTTGAAAAGGATTTCCCAATCAAGTTCCTTGACAGGCGTACGCAAGATTTTGCAAAAAAAATCGGTGGCCGAGTTTACTCTTCTGGCGGCCACGTAACAAAATTAACAAGGAACGTATAAAAAGGAAAAAAAAATTTTCGTAAAAAGGTACCAGGGACCGAAGCAATTTGAGGAAGGAAGGAAATTTGAGTGTCACTCAAATGATCTACCGGTTTTAAGTCGGTGGCCGCGGAACAGAGAAAGCTCGGCCCCCAAGTATTTTTTAAAATATCACGGATTTCTGGTCCCTGATAAGTTTGAAATGGAAGAGTAAAGAACGAACTAGGCTAGCTCGTCTGGGGCAGATTCACGGCGTTGCGTGTCGCGTTGCGGCTCGATTTTAGTTGTAAAATTAAATATAATTGTCCGTGTGGAGTACACGACTTTCCCACGAGTTTTCCGACCGGCGATTGTCAAGGCCCGAGCGCGAAAAATTCAATAAGGAACGGCCAGCCGTGAGATAGGATTTAAAAAATATTACACAACTATTTATTCAAAACTGGCAATTATACATACGATAAGTATTAACTACATACATGGCCGCGAAAAACCCGGCCACCAATTTTCGCGGTTCACTTACCGGATCTCCTCCTGAAATCAGTCTTGCCCTATAAAATAAGGGCATTTTTCGGATCATAGTGAATGAATTATTTAAGGAATATTATTTTAAAGAACACACACCACACAAGACATGTGAAGGGAAGGAACCAGGGAAAAAGAGACAGGGCAAAATACAATTTCTCTATTATTCCGCTCTGTGTTCTGACTAGCAAATGCAGAATCAGTGATGAAGAAACTGGGAATTTACGAGGTATTTAGCGAGATGGTGACCGCGAGGATGAGGAAAAAATCGGCCACCGCAAGACTTACCGGCTTAATCAATTGACCTGGGCCCGTATGTGATGGAACAATCATGTGAGAGCCGGAGCTTCACTCGTCATAGCTTTGTGTCTAGGTGGCTCTCAAGTACTGCTGGAGCTGAAAAACTGTAAATTTAATTTGAAATTTGTTTCGGATGCAAAAAAGTAGCGACACCTGCCGGGTTCCCACAAGATGTCGTTGAATTGACCTAGTAGAATCGTTAGTGATCTACCGAGCAAACAAGTATGCTTGCAATAAAAAAAGGCGTGTGGTTCAAGGTCGTTGACAAATTCGACACTTTGGACACACGAAATTGGTTATGAGCCACACCCCGGCTAGCTTAGGTCAGGAGAAGAGCCTCTCCGAAGAGGACCCCATGTGCGCGCGCGAGCCGAGATTCTGACAACATGAGAAGCGGAGAAGGCGTAAAGGGAGAAGAGTCTAAGTTGAGCTTGTTGCTGAAAATATCTAGGACTCAGGCTTAAGCTTGGGCTCAAGGCCTCATGCTCAGGCTTAGGCGGATCAGGCTTAGGCTCAGGTTACCCATAGGCTCAGGCTGCTCAGGCTTAGGCTCAGGCTTGGAGAGGCTAGCTCGGAATTGGGCTTCGGCTGCGGCCTTGGCTTGGATTAAGCTTAGGCTTAGGCTCAGCCTTAGAATTGGGCTTAGGTTCCTGAGGCTTAGAATTGGGCTTAAGCTCAGGCTTAGAATTGGAGGCTTAGGCTTTGGCGTAGGCTCAGGCTTAAGCTCAGTTAGGCTCCGTTGGCTTAGGCTTAGGCGTTTAGATTTAGAGGCTTAGGCCCTGGCCTAGGCACAGGCCAAGAGGTCACGCCTATCACTTGCTCCTAGATGTGGTTGGGGAAATGAAATTCTAGTGACGTCAAGATTCTGGAAGAGTTCCGTTGACGCCACCAAAAGCAACAAACACTTCAAATCTGAGAAGATCAGGGCGGAACAAAATGTACTGAAAGTACAAAAAGCCCGCATTTTTTTCTCTAATAATACTACATATCATTTGAGTGGGGTTGAAAAAAATGTGTTGCAAGAACTTATTCGGGGCGAAAAAAGATTGAGAGGAAAGAGGAACTTGTTTTTTTGTTGGAAAATCGTAGGTGTGACGTCACTTCTCTTCCAACGCCCAGGTTTCTAGGCAACTTAGGACATTGTGCAAAAAAATCACAGAGCAAAACTACAAAACCCCAGGAAAGAAATGTGCTCTTGGCCAAAATAATAAATATTGGTTACGAAATAAAGGAGAAAGAGAACGAAAAAAAGCTTTAAAAAAGAAATCAAGGAGGAATGTGGAGAAGAGCTTGTGAGGATATACCCAGCAATTAGGGAGAGAGTACTACGCTGTCGGGAGATGACGTTTCGAGGATATTTCTAAATTCACTGGAATGAAGGGTGGTGGAAGAGTTTTGTAAAGTTCGGGTATAGGCCAGGGGTTTTTTTGGCCAATGAGCCTGGTGCATCGAAGAAAAGCTACATTGGAAGGTTTTATGTCTCGGCCACAATAAATTATAAAACCTAGTACGATGAAGCACACTTGCATTAGGATTGCAAAAATTTATTTGACAATTGAGAAGAAAGAAAATCAGGGGGGCATAAATGCGCCATAGAACAGTGCGATCAAATTGTAGAAGAACTTTCGCCCAAAAAGCTAGGCCACGTAGGAGACCGCTGGAGAAAGTACGTGTATATGGTGGAAGAGTTTTCTTGTTTTTCTAGGCAATCTTGCGACAAAACTTGAATTTATGAAAAGATGGCTTGGAAGAGCTTTCGCATAGAAAATCTAGGCCACGGCTAGCAATTTAATAGGAGATAGAAAACCGCGTCGGAAGATTATTTAACTTTTCCATAAAAATTAGCAAATGTAAGAGAGTTCAGATACTGATCTGGAAGAGTTTTTGTGCAAAAAACCTTGGCCGCGACCAGCAACTAAAGTAGTAGGGGAGATAGGGTACCCCGCTAATTTTTTATTTATTTTTCAAAGAAAAAGTTTTAAGGCTTCGGGATTTGATGAAATGGCTCGGAAGAGCTTTTGCCGAAAAACTTAGGCCACGGCCAGCAATCTAATGAGAGGGGGAGGGTTCCCCGTTAAATTTTTTTTGTTTTTTAAACAAAGTTTTGGGGGGATTTGATTAATTGAGCACCATGGAAGAGTTGTTAAGCAAAAAAACCTAGGCCACAGCACCCTGAGAGGCGGGACCATAAGGTAACCCTACGCTATATTTTTTTTTTCAAAGAAAGTTTTAAGGTTTTGGAGGAAATTTGATTACATTACTTGGAAGAGCTTTTGCAAAAAAAAACTTAGGCCACGGCCAGCAACCTAACTCAGAGTAGAATGGGAGATAGGGTACCCCGCGGAAAATTTTTAGCGTTAATTTTGGTAAACAACAATGGAAGAATTTTCCGGTTTTCTAATCCATCGCATTTTCAGCGTCACGGATTCTGTGGCTTCCCCTCGCATAAAATGGAAGAAGTTGCCGACCTATATCTGGGGTAGATTTACAGTGCGTTGCGATGTCGAGTCCGCCGCTCGAATTTAGTTACAAAACTAGGTAATGTAATTATTTGTCCGTGTGGAGTACACGACTTTCCCAGGAAGGTGATTGTCAATGAAGCGCCAAAAATTCTCAACCAAAAGAATCCAGATTCCCGCGCAGCATCGCCTAGGAGAACATTTTCAAGAAATCTGGCTCACGAAGGATTAAGTAAAACAAGAAAAGAAATAAAACTCTAAGATGAAAGGTAAGGGTGGATGCGGGACAACTTATCACTATTTGCCATCATCATCATTTTTCTTCTCCTCCTCATCAGCTTCTGCTCCTCCGCGATCTCGCGGTGACTCTTCTGAAATTCTTAACTAGGCCAACACAACGTCGGCAACGAGTTTCGAACCCTTCACCCACAAACACATACGAAAAAAGCTCCTTAATTGGAGCAGGGAGACGGAAGAGGCGAGGGAGGAGAGGCTGGTCAATGAGTTAGAGTAGAGAGAGAGAGAGAGAGACTGAAAGATGAAGTATAAGCAGAAGTCGTCGGGATGACAGAAGTAGGAGGAGAAGAAAACGTGAGAGGTGGAGTCAGAAGGATATAATATATTACATTCATAGCGAGGATTACAGTTTAACGAGGCAAAACAAACGAATGCTCCAATATGAATTTTTGGGGTTACTGTAGTTTTTTCTGTAGCCTTATACTTCCAGAAGTTACATGATAAACATATGCGAGTTTTTTAAAATTTGCCAGAAGCACGGGTTCATTTTTTTCAGGCTCAATTGACAATCGCCTGCCGGACAACCCACGTGGAAAGTCGTTCCGCACGGACAAATACATTTAATTTTACAACTAAAATCGGCGACACGCAACGCGTCGTAAATCTACATATATGGCCGAGCCAAAATGACCGACTAGTTTGGCAAAGACTCTTCCATTTCAATTTATGATGGAAGCCAGAAATCCGTGCAGAAGTTTCTCGGAAAAAATACAGAAAGTTTGTGAAAGGGTTGCGACCTCTAACGGTCTTCATTAACATAAATTCAAATTTGACGCGCAATAATGAATTGCGAAATTTACTAGCGAAACATGGTGCATTGGGTGTTTGAACCACAATTTTACAGATCTGTGGTCACTAACATCAATGCATGGCCCGAAGGGAAGTGGTACCTGTACGCAATTTATCTAACGTAAACCTGGACGTTTGGGCGCGTGTATCTCACAAACGGTTGGTCCTGTTTTTTTGTGATGCATTTAAAAAATTTGAATTAAATTCTAAATTTATTGGACCAATGCTTTTTTCGTTGAGTATCACGCGCCCAGACCTGGTCTACACTCAAATTACCAGTAGAGCGCATTTGCTGACCACTTGCTGTCCGGGCCGTGTTCAATGCAACGATGGCGCGTCAAATCGACTGCAACTTCAGAAATCCCTAGTAGTTGCGCTTCAAATTTGATGCATTGCACGGCCCGGCAAGTGGTACATCTATGCAAATTCGCTCTACTGATAATTCAGTGAAGACCAGGTTTGGGCGCGTGATAACGAAAAAAGCTTTGGTCCAATAAATTTACTTAGAATTTAATTTCGTACATTTTTTATATGCATCACACCAAGAAAAAACTGGACCAACCGTTTTTACACGCGCCCAAACGTCCAGGTATACGGTAGACAACTTGCGTACAGGTACCACTTCTCGGGCCGTGTTGAATGTTTGAGTTAAAATTTTGAGTTATATGTGCTGGAAAATTGACATGAACATGGTATTTTTCATTATTTGCGCGTGATGGTGCATTGAAGTCGTTTGCAAATTTTTTTCAGAGCTGAGGTCAACTGACACCAAAGCAACAGAGTTGACGATTTTAAACTGCACTTTTGCACGCTTTGCAGTCGGTATTTGGAGGTTATTTTCGATTGTTGTGTGAGATTCACCGACACACCAGATTGGATGACGCGCAAAATTGTACGAAAACAGTTAGTTAGAAAACTAATAAAAGAAAACTATTAATAAAAGTATAGCGAACATCCTGAACAATTATTTCTGCACCGCCAATGTATCTATAGCATGAATTTCAAAATATACAAAAAAAAATTATGAAAACCACGACGAAAAACCCGGAAGTGTTTTTTGGGTAGCCTGTCTGGATTCCTGAGGGTATTGAATTTCGCCCTCGAATAATATTGTTTCCTTTTTCCCCAGAATACCTACAGAATTTGGGGGAAAGAAATGAACTGTTCCTCACATTAACCTACACGTTCTTATTTTTAATTAAATTTAGGCCACGCCCAGAAAGTAGCTGGGCGGGGTTGCACATTTTTCTAGCTTTCCAAAATATAAAAAGTCGGAAAAAAAGTTGTAGTCCGTAGTTTGTAGTTTGTAGTTTGTATCAGCTTGTCCCATAAGTTTTTGTACTTTTTTTCAACTATGTTTCCAACGTCTAGAAAGTTTTAAAATTTTTTCATCGTAGGTCGTGTCAAGCGGGTCGTCCCGGGCCTGTCACAAAAGATTCATTTCATCCATTTCTACTTTGCCACGATGACAATCATCAAACCTGAACGTCGAGACGTTAGATTGCTTCTTCTTTATGAATTTCGTCTTACTTAGGTCATTCAGCAATGGAAGCGGAACGAAACATATGCGGTCCGATGGGTGAGGGAGCACTCTCTTATAATACAGCACTCAAGAGTTTCAAAAGCTCAAGACGGCGCCGACTTCAGTCTCGAGAAATAGAACGTCAATGTGGGCGACCGGAGGCTACAGTTAAATGAGGAAGACATAGGGAAGCTGGTGGAAGCGCCTCGTCTTAGTCTTCGTGAAATGAAAGAGAACCTTGAGTGTTGTCACAATAGCAAAATTGCACGTCACTTGGGTCGCCTTGGTTTTACTTCAAAATTTGGAAGCCTGGGTGCCTCATGAACTTTCGGCATCACAGAAGCTCACTCGGGTCACCGATTGTACTCATAGACTTCTACCTTTTCGTCGGTACGATTGGCTGAACGACCAATCTTTACGGGAGATGAGAAGTGGGTGCTCTATGTTAACCCACGAAAACGTCTATGGCCGATCGGTGAGAAAGGAATAGCGACGCCAAATGATCTTCACCCAAATTATGATCTGTATCTGGTGGGCTGTTCAAGGACCCGTGCACTGGGAATTGTTGCCCACTAATAAAACTATCACTGCTGATTCCCTGACTATTGTGCCCAGACCGAGTTGCAAAAGACCAACGGAAAATATGAAAAACTATATTTTCCAGCTTTCACGATAATGCTAGTCCTCATGTCGCCAAGAAGACTTTGCAAAAGCTGCAAGATCTTGGTTGGACTGTTTTACCGCATCCACGATATTCTCCACATCTTGCACCAACGCGTCAAACTACCAGTTCTTGTCTCTCAGTGACTACTTGCGCGACTAGCAAAGTTATTCGACGACGAAGAGCATCTCAACTGAACTCTCCACTTTCTTCTCATCGCGCTCGGTACGCATTTCTTCTCCCGTGGCAACATGATGTTACCTAGTAAATGGCAACAATTTGAGGTGGAAAGGTGAATACTTGTGTGTATAGTACTACTTGTCGCTTGAGAGAAATAAATTTTTTTTCAAAAAAAAAATAGTAGAAAAACTCATGGGACAACCTGATAGTTTTAGTTCGTTATTTGCTAATTGTTAACGTTAGTATTCGCCCAGGAGGGCCGAAATAAATAAATTTTAGAAAAGAAAACGAAATTATATACATAGTCATTAAAATGTGGTAGTTTGTAGTTTGTAGTCGATGTATTATGTCTATTCAAATTGTATTATAAACAACATCTAAAATTAAACAGGAAACTTATATTTAAAAAGAAAACGAATACTGAAAAAAGGCGGCTGCATAGTAAAAAATAATGATTCTCCTCCAAAAAATGGAATTCCATTTTTTCAGCGGCTATTTTCACGATGATGAGAGGAGACCAACAAAAACATTTGAGATGAGAAATGAGGGGAATCTTGCACAATTGAAAATGGGAAGTGATTTTTTTAACTTTATACACAGTTAAAATTCCAGCGAAGATCTGCGCGCAGAGTGTTTTTGGCGTGGATCGCGAGAGAAAAAGGAACCGGAGGTGCGCACAGCATTGTGCGTCCATCGCGAATTCTTTGAGATGCATTAGAGTGCGAGCATCGCGAACATAAATAATGGGCACATGTGGTTTCTCCTTTCTGATGATATTTTACTCTCTATGGCTTCTCCAATTATCTTTATCTTGTACTCTGTGCGCTGCCTACTATATTCTACTCTCAGTGTCACCAGTCATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCCTACTATATTTTACTCTCTTTGGCTTTACCAATTATTACTGTGGCTTCCCACTATATTTTACTCACTATGGCTTCCCACTATATTTTACTGTCTGTGGCTTCCCACTATATTTTACCCTCTGTGGCTAGTCCCCACTATATTTTACTCTCTGTGGCTTCCCACTATATTAGATTTACTCCTGTGGCGTCATCAACTATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCACTAAAAATGTTTTACTCTCTGTGGCTTCACCAACTATTTTACTCTCTGTGGTTTCCCACTATATTTTACTCTCTGTGGCGCTACCCTCTATATCTTACTCTCTGTGGCTTCACTAACTATTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTATATTTTACCCTCTGTGGCTTCCCACTACATATTACTCTCTGTGGCCAACTATTTTACTCTCTGTGACTTCCCACTATATTTTACTCTCTCTGGCTTCCCACTATATATTGGTTAATATCTGTTACTGGTCACCATTCTCGTCGCTTCCCACTATATTTTCCCTCTGTGGCTTCACCATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTAAATTACTCTCTGTGGCTACACCCACTATTTTACTCTATGTGGCTTCCCACTATATTTTACTCTGTGGCTTCCCACTTTCATATTTTACTCTCTGTGGCTTTTTCCACTATATTTTCCTCTCTGTGGCATCACCAACTATTTTACTAACTCGGTGGCTTCCCACTATTTGACTCCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCACCAACTACCGGTTTTTACTCTCTGTGGCTTCCCACTATATTTTTATCCTCTCAGTGGGTTCCCATAGCTCTACTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTTGGTGGCTACACCAACTATTTACATAACTCTCTGTGGCTGCCCACGCTGTATATTTTACTCTCTGTGGGCTTCCCACTATATCTTACTCTCTGTGGCTTCACTAACTATTTTACTCTCTGTGGCTTCCCAATATATTTTACTCTCTGTGGATTCCCACTATAACGATTTTACTCTCCTGCCTACAATATTTTGTCTGTGGCATTCCCTCTATATTTTACTCTTGGCTTCACAGTGTATTTTATTCTCTGGCATCACAATTATTATATTATACTCTTTGTCTTCTCGCAGAAAGGATATTTTACACTCTGGCTTCACAGAATATTTTACTCTCTGGCTTCGCAGAATATTTTACTCTCTGGTTTCGCAGAATATTTTACTCTTTTTCGCTATGTTTCACAGAATATTTTACTATCTATTAATCCAATTCTTCGTATAACAATCTATTTTTTCGTATTAACAATCTATTTTTTGTATAACCAACTAAACTCGACTTTTCCAAAATTACAGGAACCCTAAGAAATTCTACAGGACTCCTAACTCGCAACCTGCAGTTCAATGAATCACCTCGTTTTTTCACGCGTGACTCATGACTTCCACATTAGTTTACATTTCCTTCATCCATCGGTGTTGGGGCGCTGTTAATATACAACAATTAGAAGAGACCCCACCTCACGCTGCTATTTCTGCTGCTGATCTGTCAAGAATTCTTACCGCCACTTATGACTCATGCCATCAATGACTACTTCCTTCTTTTTTATATTTTCGGCTTCATCTCGAGTAGCAAATTTAACAAAATTCAATAGGTGTGACGTCATCACACCTTCCAGTGGAGAAATCCAAGATTTCTCTCGAAAGGATCAATGTGGTGTCATGGCCAAAACTCCAGTGTGAAACCTAGGCTATGTTAAATATTGAAACCGACTCTAAACTGAGCACATAAGGCTATGATGTCATGGCCTAGAAATCCCAGATTCTATGACGTCATGAAAGACCTGAACTGCACCGAACCTACGAATACCGTCAAAAGGGGTCCTGCTGTGAAGTCTTGTTCGAGAAAACAACTGAGTGCGAAAACTACGGCTCTCCGTAATCTACCATGTGGTAGATCATGCGGCCCTATTGATGGTAGAAAACTTACAGCTTGAAGCTATGTCTTACCTAGAAACTCAATAGTTTTGACGTCATCAATGGCCTAGGTGTATTCGAATGACGCAGTGTCTTAGAATTTTCTGAATATCACACAAAAGTATAACATCTTCTTGAAACCAAATAATTTTGAGGGAATTTGTAACACCCACCCAGTATTGTAACAAATGATATAATAGCGATCGGAACATTCGAGAAAACTGGAAATTTGAGACCTTGTTCGGGAAACTTACCAGTGATTATGCCCAGAGGATGGCTGTGTCGAAAAATGTGCCTAGGAAATGGGATTAGAAAACACGCTTCTTCCTTTTTTTTTCTAAGTACAGAATTACGTTGATAACGAGAAGTGCATTTCATTTTTGTTAGGTTGGAAATTTGAAATTTAAATATTCGTCTCTAGTTAGCACAGCCGTGGAAGACTTTTTCAGAAACGAAACTTTAGCCACGTGTCGCTGGCGGTGCCCACGATATTAGAGAATGTTGATATTTCCTATTTACTTATCTGTGATCATCGAAATTTTAAGATAAAGTTACTACCGTTCAGTTACACTGGTGGAAGAGTTTTTAAGATTTCCCACCGCACAGTTTGGGTGTGCCAGTGACCCTAACACTAAATTTGTAAAATTCTTTTTTCAGCCAAATAATCATATGGTGGTGTCGCCTAGAACCAGAAATTTAACACCTGAAAACTCTTCCATATTTTTTTAATTTCTGAAATCCAACGAAAAATAATTTTCAAACTCCTCTTCCTTCGAATGTTCCAGAAAAATAAAATAATGTGACGAAATCAAGTTCATCTATGAGTTGTGTGGAAGAGTTCAGATTCCTAGGCGACGTCAAAGTTTGAGGGCCCGTGACCCTATCTCGAGACTAAATTTTCCAATTTTTTCAGCCAACCCCAATCAGAAGCTTTCTCTGGCCTGTAATGACATGACAATCGGATATTATCATATGAAGTTTTTTAGGTTAAATTTCTGAGGTCATTTGCAAAGGTGTCATGACTATCATAGTTTGGAGGCTTTTTTGTAACGGTAGGGGTATGAAACTTGTTACTTCTCGAAACGGTATTATGTGGGGGAGAGGAGAAGGAAAGAAGGAAGGTTAGCCAACAGAGATAAAGCAAATTTTGTGTTAGTGGTGGCAGTTTTGAAAGAAGCCATGCTCCAAGGTCGGTTTGTCTTCTTCATTTTTCGGTTTTCTTTTTTGTAATGATTAAAAATATTTTTGTATAGAAATAAAAATTCAATACCAAAAAAATAATCACTGGAAGTTTCAACGTATCGTTTGACGCCTTCAAACATTTTTTAAAAATTCACAGTTTTTCAAATAGATGTACGTACACGTGGTGTCAGAGTATCTCACTTAGTTTCGGCTTGACTACACTTCAAAAAATGCGGGAATCTCCAAAAAAATGTGGAAGTACAGCACGCTCTTATGACCATGCGAAATCTTGAGAACTCTGCGTCTCTCCTCCCGCATTTTCTGTAGATCAGCGTAGATGAAGCCGAAACGAGATACTCTGGCACCATTTTATTTGTTTAGGGCAAAAAATTCCCGCATTTTTTGTAAAGGGATCAACCCGTAATGGGGCGGCCTAGCCCCAGTTTGCGTGCATACTTATTCCTGATGCCGAACGACATTCGCCGATATCCCGTTTTTACAGTATGACTCCCAGTGGGTTACTGTACCAGATTTTTGGTGCTTTTATAATATTGTTTTCTTTTTCAAAAATCTATGACGGAAAAATTTGTACAATTGTTTTTTTTTAATATTTGAATTTTTTCGGCTCCCAGACATTTTAGCGGGATATCGGAGTATCGGCGCATGTAAACGTTTTTTTTTTGGTTTTTTATATTAAAAACGGTTAAGTGTCGTAATAAGACGTGATTCATTTGAATAAAAAATAGCGAGCGACGCCGGCCACCACGACTTAATGGCTTCCCGTCCTAATAACAAAATGGAAGAGTTTTTGCTCCGAACTAGGCCATTTTGGCTCGGCCGTATCCGGGGTACGATTTACGGCGCGTTGCGTGCCGCATCGCGGCTCGTCATTTTAGTTGTAAAACCTAATGTATATGTTGTCCGTGTGGAGTACACGATTTCCACGCGGCGGTTGTCCGGAGGCGATCAATGGCGCGCAAAAAATTATGCCTAGGACAGGACACCGATTCAAAGATATAACGGCCCACATTTCAACAGCGGTATATCGCGAGGGAGTGTCGTTAAGCCTGCACACGGGTTTCTGGCCTTTTCATTGCTTTTGCGCGCTCCATTGACAATCGCCTGCCGGGCAACGCGTGGGAATCGTGTAATACACACGGACAAATTTTTTTAAGTTTTATAATGAAAACCGCGACACGACATGCAATGCGCCGTAAGTCTACCCGGGCCGACCGACACGTGGTGTCGGAGTGTCACGGCTTGATCTACGTAGACCTACAAAGAATTTTGCGTGATTAAGGACTAGTGAGGTGAAGTCACACAACTCTTATGGGCAAAAAATTCCCGCATAATTGTAGATCAAACCGTAAAGGGACAGTCAAAATGGCCTAATTCGCTCTTACATTTCAAAATATAATGGTAGGCAAAAGCATGATGGGGAATTTGTGATTAGATTTTTGAAAAAGGAAATACAATTTTTTCCAAATTTCTACTGAAATTTTTAAAAAAAATGTATTTTTTCCCTAAAATCTTCAAATTTCTGGGGTAGTTTCAATCTCTCACTACCGTGGTAACCAAAAATATGTTTCCTATTTTGACCTCCCGCCACACAGTTTTACTAACAACTTCTTCCCCCCCCACCCACCCACTTACTTCGTATCTGAAACTCCGCCCCATTTTTCGTGTACTTTACACTTGAATGGTGATGAGGTAGAACAAATCTGTGTTTATTGGAAGATCAGCAGTGGTAGCAACAGGAGAAGAAGAAGAATCAGCACTGTGTGGAACCAGCCAGCTGTGTTGTTGTGGTTTTAGTCCTGGGGCTAAGGGAAGAGAGAGGACGACGTCGTGTGTCTTCAATAAAATGAGGATCTGCTCCTATTCCTGACTTTCTTGGCTGGAATTGTTCAGGTAAGCCGGGGTTTAAGTATTGATATTGGTGCTATTTGAAAATTATTTCAAAAATTTTCGATTGGAAAATTTTTTTTTTTTGGCCCAAAACTTTCTTCTAGAACTTTATCATTCCTAGGCATACTAAATATGTCTGCAAATATTATTTTTTCTGGAAAAACACTTTTGAAAATGTACATATGGATAGCAAGTTTGGTTTTAGTATTATTTTGAAAAATTATATTTTTTCAAAAAAATTTTTTACAAATCTAGCAAGAAACGATTTTAAAAACAATTTTAGTCCATTTTCTTTTTTGTTTTTTGGAAATTTCACGAAATATCGGCCCAAAATCAATGCAATACTATTTTTTCACAAAGAAATTTTCAAAATTTGACAATATACAGATCTAGGGCTTCCATGTTAGGCAGGCGCGGTTGCAGACGGCTGCCTGAAACCTGCCTGGTTGCCGCCCGCCTTAATTTTTACGGGAATTTAGAAAAATTTCTAATTTTCTCATTTCTATCAATTTGATTAAAACCAAAATAAATTGCCGAAGCCAAAGGTTGCCTTAAAGACAGGCAGGTGGGCGTTTTAACGCCGAGCAGCTTTACAAAAGCACTATACAACTCTGTTTTTGAAATCTAGCAAATCTTTAAATCAATAAGAGACATGGTGGACAAGACAAAGACATCGACAAATTTTCGACAATATCATCTATAATTTTTTTCGGAAAAATTTTAGTTTATACCTTCCAAATTCGCCAAAGTGAAAAAAAAGTTCCTAAACGTGAGATATTGTATGTCTTCTACACATACTAGCCAATATCAATAACATCTGCCAAGAAAATCTCGAACCAAACACCAAAACGCGGCGTTTGGTAACCGGTTTTCTCTTTTCCAAAAAAACTATACATAGTTTCTAGTAAACAAATACAAATGGAAAATTCAAGGTGACAGCGAAGAAAAAAAGAAAAAAAATAGTTGGTAGTCGCCTAAGAATTGCATGTAACGTCACACCTCGGCCTTAAGAGGGGTCATGGTACATGCTAGATGATTAACCATGGCAAAAGAGTGACGGACCTTCTCGGCCATGACAGTTTTTAGGTTTAGGCTTATTTAGGCTAAGGCTTCGGCTTAGGGTCGTAGGCTTAGGCTTAGGCTTAGACTTAGTCGTGCTCAAGCTTGAGCCTTCTTACACTGGCGTAGGCTTATCCTATGAGCCCATAATCTGAAAACAAATATTAAAAAAAAACCAAAAAAAAAAAAAAAAAAAAACAAACAAACAAATAAAAACAAACAAACAAAAAACAAACAAAATATTTGAATTTTTCTAAGAAGACAAATACGTTACTATCGGTCACGATTTTTGGGCTTTAGGTTTAGGTAGATGTTTAGGCTTAGGCTTTGGCTTAGCCTTAAGCTTAAGCTTAGGCTTAGTGCTTAGGCTCAAGCTTAAGCTTAGGGTTAGGCATACCTTATGAGCCTATAAGCTGCTAGTTCTGAAAAAGAACCAAATATTTAAAAAAAACCAAAACAAAAACAAAAAAAAGACAAACAAACAAATAATTTATCAGGTCCAAGTCTTGCTAGCAATGTTCAAGCCGCTCCTTGAAGGTGGCTGTGGTGTCGGTAATCCGTTTGCAAATCCAAAGGCGATCGGCGTAAGTTTTCGCGCGACAGGCACAGACAAACAGACAGACAATCGAAAGTAGTCCAGGCGCTGAATGGGTTACGCAATTGGTTTTGGGCGCCACGCGCACATCAATTATTTCCATAGATACATACATCATTCAGATACGTGGAAAACCAACACAACGTGAAGATTTAGTGGGTTGGCAAATGCATTTTATGTTTCTTTCCCAGGGTCTCTTCCAACAATTCGCCGGTGGAAATGATGAGGGGATTCGGGCCTTGCTGGAATGGCACCGGTATGTGTTGCGACGGTTAAAACGGACGTTGTGAAAATTTCCGCTTTGGAATATATTGAGAATATTCGAAAATTTTTGTAAAATTTTCGAGATTTTCTTCTAAGCTTTGGCGCGCATCTTAGGCTTAGGCTTAGGCTTCGGCTTATGCTTGCCTAGGCATAGGGCCTATAGGGTGCCTTAAGCGAATTAGGCTAAAGCTCATGACTAGACTTATTCTTAAATTTAGCCTTAAGCTTAGGCATGGAACCCTTAGGCTTAGGTTTTTGCTTACGCTTTAGGCTTTTGCTAAGGCCTTAGCGGCATAAAAAAAGGGATGCCCAAAGTAAAAGACAACTTTTGACAAATTTGAAAGTGAAATATTATATTTTAAGCCTATTTTTTCCCTAAAAAGAAAAAATTACTTTTATAGTTTAGAAAACTATTTTTTGGCAGTGTTTTAGCCGTCAAAATTATGGCTGAAAAACAAAGTTCAAAATATTTTTCATCTAAATTCTTTTAAATTTGCTCTACCTTGAATATTGAAATAGTTTAAACAATTTAAATTATTAAATTTCAAGTAAATTCTAAAATTTTGTTCATTTATTGAAGTTTATGTTCACTCTTACAATATAAATTAGGGTATAATCCTCAAACATTCCAGAAACCAGCACCAGCCGCAGCTGGACCCCGCTCAGCTCCAGCTCCAACCAACGAGGATTACAACACCGACATCGACGTCCCAGCTCCAAAGGCAACGAAGCCCGTGCAGCTCCAACTTCCACGAAGAGCACAAGGTGCTGATGATGATAATATTGATATGACTCTTACACGTCTTGGCTAACTTGGCATGGAAAAGCCCAATTCCTTTAATACAAAAAACTTTTGTCAAAGATTCTCAAAATTTTGCACTTTAATTTTTAAGTTTAATTTTTAAAAAGTTGTGGACTCTCACGTTTGTTAACCATTTTATATGCAAATATGATCCTTATTACTAACAATTTTTAGTAATCTAAACATAAATTGGAATATTTGGTCTTTTTCCCGCCGAAAATCATCAAACATTCCTTAGCAACGGAAAATTGCAGTGAATTGTGTTGGTTTAATTTTACCGTCATTTTTTCCGCATATTTTTTGCCATAGCTCTGCTGTGTTTTGTGCCATCCTTTTCTCTGTGCTATAGAACCTGTTACGTACTTCAATAAATGATTTCTTTTAAAAGTTTTCGCACAAAAAATATAGTCGAGTAGCTGGCAAAATACACGCCATGGTGCAAGAATGTCTCATTTCAGCTTGATCTACGTTGATCTGCAAAAAATGCGGGAGAATGGAGACGCCGTGTTTTCTATTGACTTTGCCTGGTTAAGAACGTGCTGAACGTCACATTTTTTTAGACAAATTCCCGCACTTTTTGTAGAAAGCCGTGGTGGGACATCCTATCCCCACTTGCGCTGGGGGGACAAACCGACATAAGTTTTGAAGACATATTACACATATACATTTAATAACATCTATGTTTTCTGCGGAGGGAAATTAGATTAGAGAATTTCAGCAAAAAAATTCTGATAGCTTTTTGATTTATATTATAAAATTGTTCTTTTTTTTTAGCGAATTCTGATTTTTACAAAAAAGAAATTTTGCGTGAAAACGCTGCCAATATGTGCCTGTCTTACCCTAAAATAAACATTAAAATGGTTCAAAAATTATCTTTTGGAACAATTTTACGGGTCACGCGAAATACTGTCTTAGTTAGTTTTTTTTCTTTGAAATTTATTATTCCCAATATACGTAAATGTCACTGCAAGTTAGAAAATTATACTTGTTCTTTTTCCAGAAATTGAAATGTACATGATACAAGGCTGATTCCATGCAAAATCTAATAAAATTTTTAGAAACAATTTTTTGTCAGAGTCTTGAATATTGCCTTGAGCTATAAGTTACCGTTTTTTTTTTAAAAAAATCAGTTTGGCCTAAAATCTTAAGACTAAGATTAAGCCTAAGCCTACGCCTAAGCCTAAGCCGATCAAGCTTAAGCCTAAGCCTAAAAGGGCCTCAGCCTAAGCCTAAGCCTAAGCCTATGCCTAAACTTAAGACTAAACCTAAGTCTATTCACTAAAATTTTGACGTAAAACTTGTGACTAAAAATTTTGGAAAATTTTTTATAAGTCCTAATGTTTGTTTTTCTAAGCCTAAGTCTTAGTCTAAGTCTAAGTTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCCAACTCTAAGTCTAGTCTAAGTCAAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTACTGAGGTCTACGTATTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTATCGGAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAATCTAAGTCTAAGTATAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTGAGCCTAGTTCAGCCTAAAAAGAGGTCTAACGCTTGCCACTGACGCACGCTCTCTAACGCTCACCACTGAAGCCACGCCTAAGCCTTTATAAGCATAAATCAATTTGAAACTTCAGACTTAAATTTTTGGTGGCCTATACTCTGTTAAATTTCGCTTGTGATCAGAAAACGGGACCCCTTTGTTACAAAAAAAACTAACGCTCGCCACTGACGCCAAGTCTAAACCGTAATACTAAGCCTAAGCCTAAGCCTAAGCCTAAGCGTAATAAGGCGTAAGCGTAAGCGTAAGCCTAATAAGGTGTAGTGTAGCGTAAGCGTAAGCCTAAACTTAAGCCTAAATCTTTGGACAAAAATTTTAAAACTTTGACCTAAACTGCGATACTAAATATTTTGGACGCAAATCTCGGCCTGAATTTTTGGAATAATTCTGGGAACTATTCCAGAGTAATTATAATTAACAAAAAAATTTTTATAGTATTCGGCGTAAAACAAAAAATAGATGCAATGTTTTCAGTAATAAGTTTGAAATTTTCGAAAAATTAAATATTTCTTCGAAACTTCGAAACTTACTTTTCTCTGGAATAACCCCAAATTCTAGCCGCCGAGATGCCCCGCCAGTATACCGCCAAACAGCCTCGCACAAAAGCCAAAAATCGAAAGATTCCGGAATATCGGACATTCGCCGTTCGTGTACGTGGTGAACACCACACCAGCTCCTCACTTTGATAACTTCATCTGGCCACAAAATGCAGCTGTCCCAGGAGCCATTCACATTTGCTCCATGCTCCTTCCAAACTCTTGCCACCACCACCAGCTCCAGGACCCGGCGGCTCGGACTCTTGAGCTATTTTTACCGACGACAGCTAGTCCGAAGCTGTTCTCATAACACTGCTAATCAAAAAATTTGAATACTCAATACCTCCTTATAACTTTTTCAAATTCCAGATGATCCGAGAAATCGCTTCATTTTCCGACAGAGGACGCTCCAGGGATCAGGATTTTGGCGCAGTCGTCTTCAAACGCTCATGCAAGCCCTTCGAAGCAGTCTCCAGTCGGAAATAATGGTGGAGCAGGAGCTGCCGCCGGAGCCGGAACAGCTCTAGGAGTAGGTTAAGCTCACTAAAGACGTCGTGAAGTTTTACTATTTTTTAGATGCTCCAATGCTTCAAGCCCATCGAGATGGTAGTTGGGGGCAATCCAATCGCGCGCTAACCAACAAAAGCTTTTCGAGTCGGACATGGTGTTGACGGTCAAGCAGAGGCGTGAGTGTGGGGTACGGCGCAATAAGATTATTGTAGGGGTACTGTAAGATCTCTGTAGGGATACTGTAACCCTACCGTGATATTATAAAGGGGTGCTGTCAGATTACTGTAGGGAGTACTGTAGGATTCCTGTAGGGGTACTGTAAGATAAAATATCTGTTTAAGAGGTTACTGTAGGGGATGCTGTAAAATTTCTCTAGGGATATTGTAGAATTATTCCGACGTAGGGATACTGTAGAATTACTGGAGGGAACTGTAAGTGTACTGTAGGATTACTAAAGAAGTACTGAAGTATTACTGTAGGGGTACTGTAAAATTACTATAGAGTACTGTAAGATGTAGGGGTACTGTAGGATTACTGTAGTATTACTAAACAAGTACTTAAAGATTATTGTAGGGGTACTGTAAAACTAGAGTACTTTTAAGAGTACTGTAGGATTACTAAAGAAGTACTGAAAGATTACTGTAGGGGTCCTGTAGGATTACTGTAGTATTACTAAATAAGTACCGAAAGATTACTGTAGGGGTACTGTAAAATTACTATTCCGAGAGTAATGTAAGATTACTGTAGGGATACAGGAGATTAACGTAGAGACACTGATCGTAAGATTATTGTAGGGGTTCTTTAAGATTTTCATCTGTAGGGTTACTGTAGAATTACTGTAGGGTACTGTAAAATTACTGTAGGGGCACTTTAAGTTTACTGTAGGGATACTGTAGAACTACTGTAGGGTAACTATAAGTTTACTATATTAGTTCTGGGTACTGTAAGTCCCCGTAGAGACTTAATAAGATTCCTGTGGGGGCACTGTTACACTACTGATAACTAAAACGGTACTGCACGGTACTATAAAGCGACCACCCTAGATTCATGGTTATTTCAAAATTGTGCTGCCGCCCAAGAGGCCCGTAAACGGACGTAAAAAGCGAAAGGTGATTAACCGGGATCCGTGTACCGATGGAAGAGTGTGATTCCCTTCCGATTCAAAGGTGGCGACGCGAAATTGAAGAAGCTGATCCGTGAAGGCCTAGGCCTATGGGGAACGGGTGTGCGATGGAGCGACAATGCCCCCGCCAAGGATTATGTGATCTTCTTGGATCGGGGTGAGTTGACATGCCCCACAGTGTAGTTTTTTCATCAGATAGTTGGTGGGTTTTTTTTCAGATGCTACTCATCGCTGTCGATCCGGAGGATCTCAACCTTATTTCGATTCGGTATGGCTGTGAAGATCTAAGTTTTAGTATTTTATACTATTTATAAATTCAAATTTTCTAGAAAGGAATCGTTGCTCACGAAGTCGGTCACTCCCTAGGTTGGCACGAGCAGTCCCGTCCGGATCGGGCTCATGACTACATCCATTTAAGAAAAGACTGGATTATTAAACCGATGGAAACTTCGAGAAACGAAGTTGGGAAGAAATCGAGGATATGGGCGTTCCGTAATGTCGGAAGTGTAATGCATTATGGGTCGAATGTAATTGTTAATTCTGAGTCGGTAGTTTAGATACTCAAAATGATTTTCAGGCCAAAGGACTGGGACCAAATTACTATTGAGACCAAAGATAGTAGAGGGAACGATTGGTCAACGGTGAGCCACATGAAGCTTTCGTTTATCGATGTTAAGCAGCTTAACAGGCTTTATTGCAATTGTGAGTAGTTACGCAAAAATGAAATAAATTTGACGACTGAGCGGATCGAACGCCCAATCTTTCAATCTGGAGTCGAACGCGATACCATTGCGCCAAGCAGACACAGTCGCAGGAAACGGATAGAGGAGAAAAGAAAAAAATAGACAACCCTACGTTTTATCAGTGGAGCGCGGTTGCAATTTAACATTCCAATTTTCAGCTGTTTGCCCGGTTGCCTTACCCTGCATGCAAGGACGATACCCCGACCGCCGAACAATAACTGTGCGGTTTGTAGCAATGTCCAGACGGTCTCGGAGGATTGTGTGGACGTGCCGCTAAGCGCACAGATCATGGACTCCACTGGAATTTATGGGAAAAAACCCCCCTAAAATTTTCCGACAAATGCGGCGGTGCTAACAGCGACCACCGAATGGCAGGAGATGGTCTACAAGGGGAAGCGGACGTGCAATTGGAAGGTGAAGTCACCGAGCGGTGGGCGGGTTCGGTTGGTGCTCACCGAGCTAAGCAGTGTGCACCGGCGTGTAAGGCCTACAACGAGATCAAGCATAATACCGACTCCCAGCAGACCGGATTCAGAGTTTGGTGAGAACCCTAGATTCCCAAAATTCTACACCTTTTTCAAAAAAAAATCGAAAATCGACCCATTTTGGCGGGAATTAAAATTCTTTTAAAAATGACAAAATATTTTTCTGCAGAAAATGTTTCGACTTTTTTTAGAAAGCAAGCTGCGTTTCACGCGGTTTTGGCTTCCCTCATATATTGAAGTGGAAGAGTTTTTGCCTAGGCCATTTCATGGCTCGGATATCTACTGGGCAGATTTACGGCGCGTCGGATTCGGCTCGATTAGTTGTAAAACTATTTAATTGTCCGAATGTGCAGTATATGCGACATTCCCACGCGTTGTCCGGCAGGCGCTTGTCAACGGTCCACTAAAAATTGAATCAGAATCGAGCCGCGAAGCGACACGCTACGCGCCGTAAACTACCCCAGATATCGCCAAGCCAAAATGGCCTAGTTAGCTCTTCGGACATTTCAATGTATGAGGGAAGCCAGAAATCCGTATAAATTTAATTTTTTGTTGCTTAAAAAAAAAAACTAAACATCTATTTCCCAATTCAAATTTCTAGCTGCTTCAACAAAACATATGACGTCATCTCCGACCACTCTGAAGCCCTGATCCTCTCCAACGCGAACATCTTGGACTACGCGTAGGGCTCCTACAAGCTGCAATGACCGATTCAAGCCCACCCCCCCCCCCTTTTTTATCCATAGAGCGCACTCTGATTTGTTCCAGACAACGGAGAAGCCACCACCGAAACCCACGACCCGGGTGTACAGCCCGGAGAGAACCATTCCGCGGTGTGGAGAACTGGGGCGGCACCATCAGAAAAGTTCATCCTGCAAGCGATTCCAAAGATCCGAGACTCGCATCGGCCACTCGAGAGTATTACTAGTATTGTTGCGGAATATGGTCTCGCAACGCTACTTTATATATAATGGATAGTCCGACCGATTTTTGCAATGGCGTGAGAGGATTATATATATATATTTGTAAATTTGGTACCATTCCAAAAATCCAATTTATCTTTCACAATTTTCAAAATTTGCTCATCTTTCACAATTACTCGGGGATTAACACATCTAATGGCTTTCAAATTCATAAATAACAGTTCATATTTAAAGTGATTATTATATTGCAGGAACACATATATCTATGCGTATCGGACAACATATTTTGACCAAATATCTCGTATCGAAAACTACGTTTAAAGGACTGTAGCGCTTGCCATGTCGATTTACGGGCTCCTGTTTTGAAATTTACACGGTTTTCATCGTTGGCTAGCTTCCCCTCAAAAATTGAAATGGAAGATTTTGCACTAGGCTATTTTGGCCACATCGTTCAAAAACTACAGTCGAATTATTAGCGTCAAAATGGTGACTACTGTAGCGCTTGTTTCGATTGTACGGCATTATTGAGATTAATTTTCTTTCGAGTTCCCTTCGTTTTTAATTTTTTGCTTAATTTGAATTTTTTTTTGAGATATTAAAAAAAATGATTTTACACGGTCTCCTGGAGTGTTCATGATTATTGGAGCGCAGTTCCTGATCCTTGCCGCGCTGATTTACTTTTTCACCGTTAGAAAATGAGTAAAATCAAAGATTCCATTGGTCAAGAAATCTGATTAAAATAAATAGGATTATTAATTTTCAAAACCGAGTCACAGGTGGTGCCAGACTGCCCCATCACGGTTTGATTAGATCTACAAAAAATGCGGGAATTTTTAGCCAAAAAATGTGTGACGTGAGCACGTTCTTAAGCATACGTTAAGAGTTGAGAATTCTGCGTGTATTCTCATTATTTGTAGATCTACGTAGATCAAGCCGAAATGAGACATGACACTTTGACACCACGGTCCGTAAATTGACGCCAGTGCTACTGAGTCATTTAAAAAGTTACTGCCTGTCAAAATAATTGCTGTTCCCGTAATATCGCATTCAGCAGGCCACCCTATGAAAACCCAAATTGGAAAAAAATCAATAAAAATTTGAATTTTGACGGAAAAAAAATTGAGACCACATTTTTGTATCTTGAATATAAACCCGTTGTTTATCACAAAAAATTAGTGAAAATCCTTCAAATCATATTATTAGTTCGAAACGTCGACGCGTAGGTGATCGATCGTACACTGGGAATTGCCGGTTCCGAGAGTTCACCGCCGTTTGATATCCTTCTTTGCAAACTTTTGATCTGAAAACATTGACTTTTGCTACCTGGTGGAAGAGCAAACTCGGTCACTATGTTTGTTTTAGCGACAAGGGTATATGCGCAAACCTACAAAATGATCTTCAAAAAAGAATTTTTTGCCCAACAAAATGAAGTGTCAGCACGTTCTGACTAACACCGTAAATCCCGCATTTTTGTAGATCTGCGTAGATCAAGCCGGAACACAAAAATATCAAAGTTTTGAATTTTTCAAATAAAAGCCAGCACACGAGAAGCTAGCCAGCTTGAACAGCAAGTAAATAAGCCACAAAACGCGCACAAAGCTCAAGATCAAACGAGAACTTGGTCGCCCGCATTGAAACTTCTGTCATGTGAGAGAAACGGTTGGGTGGCGTGATCGTTCAAGACAAATGAAAGCATGTAGACTAGTCCATCAATCAGATAGACTGCCGCAATGACTGGCAAACCCTTTGACATCCTGCTCATCAGAACCCTGGAGAAGCCCGCAGCAAACAGACGAAAGAGCAATGTAACTGATGAGGAATAGAATGAGCTCACGGAGAAGTTGAAGAGATCTAGTCGGTGCCCGGGCTACTGCTGCTCCTGATGCAGAATCCGGTGATGGGATTGGCGGCGGCGGCTTTTGCGAGATCGCGAGCTGGCATCGACTAGTGGAGCCGTCCCAGGATGAGCATGATCACGCGGGTGCTGGAGTCGTCCTAGAGAAGATCATTTTTTTAAATCCGTTAATGGACGGAAAATTTATCATCTGGAATACAGGCTGACTAGCCCTATTTCCCGTGGTAGTGTCTTATTTCGTCTTGGTCTACCATGATCTACAAAAAATGCGGGGAAAAGAGACGCAGACTTCAACTCTCAACGTATGGTTAAGAACCTGACGTCACATTTTTAATGTACAAAAAATTCCGTCGCATTTTTTGTAGATCAAGCTGTAACAGCACAAATTTCAGCCCTCAATATATGCGATGTCCTTGTCGCCTTATTCCACGACACACAGATCAAGAGCTAGTAGCCAGAGACGCGCCGTGTAGTAAATCAGTGAGGCCACTAAAGAACATGGAACATGGGAAAGCCCTCCGACGACCGACGAAGGTGATGTAATCGGTTCACGAAATCTGACTGTCTTTGGAACTTCCAAAATTCTTTTTGAATGGTTCGAAAATATTGAGTTTGAGCCTAGTTAAGTCCATTTGAAGTTGGTGGCCTAGGATTTTTAGGAGTATTCTAGGCCGCCAACTTTGGACAGCCATAACTTGGCTGAAAATGAAAATTTTTGAAATCTAATTTCACAGTTGAATTTAGCAGACAATGAGCTTAAATTTGAGAAATATTTTTGCGCCTTGCCACGAAAGCAGACCTACAGTAATCCCGCCATGCATAAATTAATGTTAACTGAAAGCTCAGAGTATGCTAAATTTAAATACAAAGTTCGATTTCCAAACATCTCGATTTTCAGAAAAATTATGAAGACGCTAAGTTGATTGGGCCTAGCATTTTCCTCAGAGTATTCTAGGACGCCAACTTCAAACGCTCATAACTTGGCTCAGAATTAATATTTTAGAGCAAAATAACAAGTATTTAACATAACAAAAATCTTGTGATCTACCGCATACAAGATGCGCCCAATTTTAAATATCTAGGCCACCAAATGAAAACCGTGACTCGGCTCAAAATTATTTCTGCTTCAACCAAAAACCAATTCATTTATATAAAGCCCGGTGTCGGCTCAATTCAAATACCAAGTTTATTTTCAAAATACCAATTTTCAAAAAAGCAATGAGCGTTCTAAGTTGGTGGCTAGGATTTTCATAGATATTCTAAGCCACCAACTTCAAACGCTTATAACGTGGCTTAAAATCAATATTTTCGAGCAAAATAAAAAGGATTTAATAGAAAATCTTGTGATCTATGCAGAATGCATAAATTCTGCAGAGGTCACTAAGTAAAATATTCGGTGCCACAAGCCTCGGCCGAAAGTTATTATTTATGTCTGCTGAGCCAACAACCAAATTCTCCAAAAACTGCTTACCTGATTGTCTTTAAACGAAATGCTCACAAGATAAACCCATGCAAAACGAGAGAGAAGAAAATGGACGGCCAGTTTTCGTAATTACTGTGAGTGGAGCATCTCGAGACGTCTAAAAGATCCTGTTTTTGGAAAATTAGGCCACACATCACACAATCCAACACTTACGACGAGTATGAAGAGTGATAGAAGTGTTAGTATTACAGAGCTCAGCGAGAGAATCACCAAGCGTCGGGTTGCGGATTCACGTCTGAATGTACTCATTTGTTACTGAACTAGGTCTACCTAAGCCTAAGCCTAAAGTAAGCCTACCTGCCCAACCTTCGGTTCGAGCACTAAGGCACACACTTTGAGGATCGATTCAGGAACAACCCGACCTGGGCATTTACCTTTGACGCAGGCGGTGATCGACCTCCCGTTGAATATCTACGTCGATGCATTACCGTCGTCCTTCTGGAAAGACAGAAGGACGATTGATTTGAAGCTCTGTATCTAATTACCCCTGTTTGATGATCAGAGGACGGACAGATTACAATCAGATGTTCTCTGTTTTTCTCTGTTTTTTGGTAGCTAGTATAGAAAACTATAGAGTACTGTAATTCCTATTTGGGGCTTCAGCTAGGTATTGTGCTATTATTAAAAAAATACAATTGCACAAATTTCTCCTGATTTACCTCGACATGTTGAGCTTGACTCCGCCCCCAATCTTGTTACTCTTTACATTAAGGTAGATGAAAAAGGAAGATCAAATAAATGACGAGAAAATTGTGCGATGGAATTTTTTTCTATAATATCAAACTTTTATTTATCATTTTAGGACATTCTGTGATTAACTTTTATAGTTTCACGGATTTCTGGCTTCCCTCAAGTGTAAAATTGAAATTGAACCTGGCCCTAAGTTTTCACTGGACTAGGCCATGTTGGCTCGGCCACGCGTGGCGCGTCGCATTCAGGCTCGATTTTAGTTGTAAAACTAAATATTTCCCACCCGTTGTCCGACAGGAGACTGTGAATGGAGAGCAAAAAATTCATTGAGGGAGGTTTCTATTTGGCAGCTTTTGGTTAGTGGTCTTTCAAAAAATTTTTCATAATTTTCAAATGATCATAACTCTGAAACTACAAATTTTTCGGCATAAAAAGTGCTTAATATTGTAAAATGTTGCTCTGTCTAGTCTATACGATAAATCCTTATTGTTCTCAAAATTTTACATTGATAAACAGGCCAATAGGTACAGCGCCCGACAACTCGCGGGTCCAAAATTCAAAAATGGCCAAACTTCGACTCGCGAGATCTCGAGGGCTAAATCTATTGACTTTATTTTTTTGAATTTTTCAATTGGAAAATTTGTTATCCAATAGAAAAATTTATGAGCAACATATTATTAGTTAAGCGTTTCTTGCCAAACATTTTATATTCAGGAGCTATACTCATTTAGCGAAATTTTTGAAAAAGGCAAACCAAAAAGCTGGCGCGGCAAACGATTTTTTCCCGCAAATCGGCGAATTGGTGCCGGAATTAAAAATTTCCGGTAAATCGGCAAACCGGCAAATTGTCGAATTTGCCGAAAATTTCGGCAAATTGTGGTTTTGCACTGTTTTTGGAAATTTCAGAATTCCAATTTCAAATTGCAAAATTATAGGAAACTCATCCTATGAATGTTTCTATCTATTTTGAAAAGTAAGTAAATTCTATGAAATTATATAAACGACGGAAAAAATTAAGACCTCGTTTTAAGTGTTTCCGTCTTATCAAAAAAGCCCTCTTTTATCCGGCAAATTGATATTCGGCCAACGAGGGAAATTGGCGAGTTGCCGGAATTGAACCGATACTTAAACTTTCTTTCGCTGCAAACTTTGCCCTCTCATCTTGAATTGCTCCTCGCTGTTCATTAACTTTGGCCCTTTCATGCACTTTCTCTTTGTTCTCCAACGGGATATCACAACGAATCACATCGGGCCACTTGAATCCGTTCCAGCACTGGAAGACACTTTTCCTGGACGGAAAGACACAATGGACGGCATGGACCAATTGGGTTGGCTAGCGTAGTTGAAATTTGAACGATGATAAGATAAAATTGTGCCTGATCTCTGATTGAAGTCACTTTCTCGTTGCACATCGGGAAGTGACGGAGCACATGAAGAATCTACTCGGAGCAGATAACGGAGAGCAGGAAGAAGGCTTGTAGGTGCGGATGGATTCAGGAGGCGTCTTTGCATGATTCCGCGTCGACGAGATTTGTGCAACTGGAATAAGGGCTTGTAAACAACGTTTGAGAAACTTGAGATTTACAGGGTCAAAAATTGCTCACGACCTCTCCGGGTGCCGATAAGTTCTTGTGCGGAAATTTGAGCAACCAAAAGTTCTGCCGATTGCCGTATAAATCGGGTACGGCAACTTCGGCAATCGCCGGTTACCGAAGAATGTTTTAGAGTTCTGCAACTTCGGCAATTGGCGGTTGCCATTTCTCTCCACGAAATTTCCCACTATTAGATTAAACAGCAAGTGCAAGTGGGGGTGACTCAAACAGGAAAGAAATCCGGCACTGGTGCCGACTTGCCGGAAATTTTCAATTCCGGCAAATTGTCGGTGTTCGGATTTGCCGTGTGCCGGCTCTCAGATTTGCCGGAAGTGTGTAGAGGGATTTTTATAAGACGGTAACACTGAATACTCCATTGTGCCTTTTTGAATTTTTCAGTGTCGTTTTCTTTGGCTATTCATAGAATTTGCTACTTGTATGGGCAAAAAAATGTAGGAACATTCATAGGTTTAATTTTGCTATTTGAAATTGAAACTCTGAAATTTCCTGGCCAAAAAAATGCAAATCCACAATTTGCCGGAATTGTTCAATTCCAGCAATTTGCCGATTTGTCGTTATGCTGGTTTGCCGGAAATTTTCAATTCCGGCATCTTGCCGATTTGCCGATTTGCCGGATTGCCGAAATTTTTCAATTCGTTAGCCGTCCACCCTGGATCCTGCCATCCAAAAAAAAACGGAAACCATTTTTGGCACATTGACGTTTTCCGCCGGCAAATTCGGCAAATCCATGTCAATGTGCTGCTGTGCCGTTTTGCCGGTTTGACGGAATTTTTCTATTCCGGCAATTTGCCGATCTGCCGACTTGCCGGTTTGCAGGAAATTCTCAATCCATCCGGCTCAATATGCTGACGATTTGTCGGAATAAATTTTCAATTCCGGCAATTGACGACGGTTTACGGCTGGAAATTATCAACTTCGGATTTTGCCAATTTGCCGTCTGGCCAAAAATTTAGGGTTAATTCGGTTCGCCGTTTTGCCAAAACTTTTAGGGTTCGGCAACTTCGGCAGTTGCCTGTATCCGCACATCCCTGTCCCACACCCCAGGTGGAAGAACTGGTGGGAGTTACTAGCGGGTCCATCAAGAATGGGACAATCATCAAGTCAACACAATCCTTAGCCGACCTTCCCAAATTCATAATTCCTTCCTTCCAAAGGCAACGGTTTCCGGTCCTTCCAACTGCTTAATACCAGCCACCACCACCAAACCCTCTCCTTCTAGAGAACAAAGTTGCATACCCCCTTTCATTGTTTTGGAGAAAGGGGCGTCTTGTGGTGCTAGTCCGGAGAGCCTGAGGACGTGACAAGTGATAGACGGGCTTATACTATCGGCTCGTCCATTGGATTTCATGCGCCTAGGCAGAGTGCACGGCGGGAGGTGGGGACGCAGGTTCCCGTCCAACTATTGCCGCAGAGCATCCCCTATCTGCTCCTATCAATTGTTCGGAGAGACTTTTTTGTGAATTTTGCCTTTTGCAAGAGGTCTGAGATTTGGGATTTGGGCTTTAGCCTTTAGGCTTTAGGCTCGCTTGCCTTGCGCCAGAGAATGGAAATTTGTCCGTATTTTCCCGGATATCAAAATATGATCGAGGCAACTATAAAAATATAGTAAAATTTTCCAGGTTTTTTGTCAGTTAGTATTTATTGATTAAAACAAAAGAGAGCGGAGATATAAGCTGTCAAAGTAGAAGGGTGGTTTGATCTACAAAAAATGTGGGGATTTTTTTTCATGCTGATAAATAAAAAATGACTCCCACAAATCCAATAAGCCTCAAACTTAAGTTCCTCCAATCTCATCCCCCTCATAAACCATTAACTAAATCGGAGTACTAGATCGCCGGTAGTATATATCAGAAGAACAGTTGCTCTCCCTCTCGAACCGACTTACACTTGAGAAATAGAATAAATTGTGGAAGAGAAGTGACGACATCATAACCTACCACTTCACAAGTTTAGATATATATATATATATACGTACTAGTTGGACTAGCTAGGACCTAATTTAGAACGCATAGGTATCGCCTGTAAGTGAGGACCTAATTAGAACTCACTAGGACTATAGTATATATATATATATATATATATATATGTAAACAAGAACCCGGGCGGGTAACCCCTTACGGTCAGAGGGGTGTCCTACACCAAGGGTATGTAAAACCGTGTCCTCCAGATGTCGACGTTGAAAGGGAAAAAGTGCAAAAGCGCGCGGCTTCGCGCAAACCGTAGCTGATCCAATGTAGCAACGTTTTTGATTTATTGGAGGAGATATTTTGCCAAAAGTGAAAAAAAAGTGCCCCATATGAGATGCGTAATAAAATTCCCTACAAGACCTTAAGAAAACGTGGCGTTGGCTGGCAAAAAACAGGTGGCAATGATAACGGTGTAGGTGTGCTTGTGTGTGTGTGTGTGTGCTAGAAGAGCATAGGCTCGTGAATCGTTATAATTGATGCTGGAGGAGAAGGAGACGATGGGCCTCCAAAGTGTTACACCTGGTATTGTTGGGAAAAAATTGGGAGAAATAGGCATTAAACTACCTAACCTAATTGAGTTTCAAAGCTTATCTTATTATAACTAAGAGGTGTGATAATAGATAATTAAAGAACTTTAAACTTATCAAAACAACGCTTTCAAATCTGTAAAGCTGAATTAGGATTTGCGTAGTACTAGCTAAAATCTAGTTGGGACCTAGGTCTGAGACTATCTAGAAACTTCGGACGGAACTATTTAGGAACAGTTAAGTCTTAAGGCCTGCTTGGGTACAGGTAAACATGTTTAGAATAGGAACTAAATAGGGAAGTACTAGTTAGACTAGTAAGACCTAATTAGAACCTAGGTAAGGCCTGTCAGTCAGGACCTAAATAGGGCGTACTAGGACTTAGGTCTAGTTAATGTCTTATTAGGACTAGTTAGGACTAGCCCTAATTAGAACCTTTTAGGTACGGCCTGTTAGGGAAGATCTGATTAGGCTTTAGGTAGGACTAGTTAAGATAGAGTTAGGCGACTCGAAGTTAGGACTAGTTAAAATTTAATTAGAATCTAGGGACCGTCAGGACCTAATTAAGACATACTAGGGCTTAAGTAGGACTAGTTAATACTAGTTAAGAACTGAACATAGGCACTGTCTCTTAGGCCTAATTAGGACTCACTAGGACTTAAGCAGGGCTAGTTTAGTTATTGTTTGCACTATTTGACTAGTTATGTACCTAATTTAGTACTCACTAGGACTTAGGAGGACTACGTTATAATGCCTTGTTAGTAATATTTAGGACTAGTTAAAATCTAATTAGAACCTAGATATATCCTGTAAGTTAGGACCTCATTAAGACTTGATTTCCGCTAGGATTTAGACAGGACTAGTTAAGATATTGTTTCGACTAGATTTTTGACTAGTTAAGAGCTAATTAGATCTTAGGTACGGCCTGTAAGTTAGGGCCTATTAGGACTGAATAAAAACTAGTTTGTTACGAATGTAGTTAGGACTAGTTAGGACTAGTTAAAACTTAATTAGCACCTAGGTACGGTCTGTTAGGGAATACCTACTTACCAGGCCTTAGGTAGGACTAGTCATGACCTAATTAGAACCTAATTATAACCATTTCTGGGCACGGCCTGTTAGGGAAGACCTAATAAGGACTTACAAGGACTTTTGTAGGACTAGTTAGGACAAGTTAAGACCTATAGTGGTTGTCCTGTAACTTCGGACTAGGACTTACTAGGAAGGTAGGAAGCTCGTTAAAAGGAATAGTTGAAAATTGGGACCTCATAGTTAGACCCTTAATTTTGTACACATCCTTATTAATATCAAGACACATTTTAAAAAAAAACGACTTTTTTAAGTTTAGCTATATAAAACTATAATTATGGAAAATTTGCTGCTTTCCTTGAAATTCGAAAAACCTAGCGTTTCTATAAAAAACCATCTGGAAGTAAATTTTGAAAAAACCCCGTCATCCAACAAAAAGAAATCTCACTCACTCACCTCGTTAAGTTATCGGCAAATCTTTGCACATCTCATGCACCTTTTGACACCTCTGCCCGTCCACACCAATGTCACAAAGAGCAACAGGAGCCTTCCTAGGTTACCCCGAACCACGACAGATGGCATTAATGCTAAGGAATTGGGCTCACAGCCTAGAGAGGGTGGGGGAAAATATTGAGAGTAAAAGAAACAATGAGAAGAGGGAAAGACGGAGGATAGGCGGGGGGGGGGGGGGGGGGCCACAACAGTGGCAGCACCACCAGGGCCTGTCCGTTGACAAATGACCCAAACGGACGGGTGGGGCAGACCTGTTGTGTTTGTTGGGAGATGGCTGGCGGTTATCAGATACTTGTATTAATGGTATAGAGAAACACCAAGAGAGCTGAAAGATGGAGAGGCGAAAGAGGAAGAGAGGGGGGGGGGTGGAAGTTTTTACGAGCCCTTAATAAATATATCGAATCAGGAAATCATTTGATGATAACGGAGGAGCGCGGGGACGGAGACGGATCATCATTATGAGGACCGAGGGGTGTGCGGCGAATTTTTGCCGAATTTGCTGTTTGCCGAGCTCCGCAATTTACCGAATTTGCCAAGCTCGGCATATTTCAAAAAAGTAGATTTGCCAAGTTTGCCGAACTTGGCATATTTCAAAAAAGTAGATTTGCCGAATTTGCCGAGCTCGGCATATTTCAAAAAAGTAGATTTGCTGAATTTGCCGGCCGAGTTTGCCGAGTTCGGCAAATCTGCCTTAGCCGAGCACGGCATATTTCAAAACATTTGCCCGAATTAGCCGACCCGAGCTTGGCATATTTCAAAAAAGTAGATTTGCTGAACTCGCCGATCTCGGGAAATGCCTATTTAGCAGCACGGCCTAGTTCACAAAAGTAGATTTGCCGAATTTCCCGAGCTTGGCATATTTCAAAAAGTAGATTTGCTGAACTTGCCGGGATCGGCATTTTTCAAAAAAGTAGATTTGCTCAATTTGCCGAGTTCGGAATATTTCAGTAGATGAACTGTGCCGAGCTCGGCATTTCTCAAAAAAGTAGATTTGCTGAATTTGCCGAGCTCGGAATATTGCAAAAAAAGTAGATTTGCCGAATTTGACAATCTTGCCGTGCATGTTCCCCAATTGAGTTTGCCGAACCATACTTGGTCCAAAAAAGGAGATTTGCCGAAATTGCCGAATTTGCCGAAACAATGTGCCCATGGCGAGCTCCTGTTGATTTTTTTCCAAAAATTCAGTAAAACGACACAAATTTGTTTTAAGAATTCATTAGTTTCGGTGCTCCGAACAACATCACAAAAGATCAAGGGATTTTTCCGAAGTTGTTAAGCACAATTTGCCAAATTTGCCGAATCCGCTAATTTTGAGATTTGTCGCACACCCCTGATTAGGACCGAGCAAAGGGCCTAACATGATCTCACAATTTGAAAAATGAAATTCAGGGATTATTCTTGGGAAAAAAGTATGAAACTCTTCCTCCGCCCGTTTCCGGCAGAAACAATTGAACCAAACGAGCCAAAAGTGCAGTGTACAGACACTTTGTTGGGAGTGGAGAGAACCAGAAGAAAGATGGAACTTTCTTGCGATGAACAAATTTTGGATCACTGGAGGGAAAGATTGGTGTTTATTAAGCTTTTTAAGTCAATATTTAGAACTCAATAGGCCCAAACAGGCCTAATAGGCAAATAGGCGAAGTAGATTAAATATGCCAAATAGGTATAGGTTGAATAGGTAAACAGGCCCAATAGGTCAAATAAGCTATAGGCGAGACTGTTGCTCAGATACTTTTTGACCTGGTAATGTTTTTCTACACGAAAAACAAAAAAGTCCCTGCTCTATTAGTTTCGGCAGCAAAATTGTGATTTTTTTCAAAAGTTTCCCATTTGTGCCACTTTTCAATAGTTTTTGATGGGTTAAATCTATATTTTCTGAATTCAGCTTATATGAATTACCCGTTTTCAACAAATTTAGGCAAATTTTTATTTTTGCCCAATCTTTTTAACCATCTAATGACTGATTTTGGGTAAATTTTCCTGAAATTGTACAAAAGCATTAGAAATTGATAGGCCAGTTTATAGGCACATGAGGTTTTTCGGAGTGGGTAATCGTCGTTAGGCGAATTATTTGGTTGACAAATTCGACAAATGCTGGTTTGCCGATTTGCCGGCAAGTATTTCATTTCAAAATATATGTAGGAACATTCAAAGGACGGTTGCTTACAATTTTGCCGGATAAAATTTAAATCTTCTGAACTGAAATTCCTTTAAAAAAAATGTGCAAACCCATAAGTTGCCAGATTTCTAATTCCGGCAATTTGCCGATTTGCCGATTTGCCGTAAATATCAATTCTGGCCAATTGAAGATTTGTCTTATTTTCCGACTTGCCGCATCCCCTGATGTAGGCATCAAAACGAATGTACACCAAGTTTTTTTCAGAGTTTTTAAGTTTACCTTCTAATTATAATTTTTAGTGAGGCTCAAAAAGTTCCAAAATTAATTCTGAAATTTGCTCGGCAAACGGCAAATTTTCCGCACACTCCTGTTTTAAATGTTCACCGCATATTTAATTATTCCGGAAATCTGATTCCCTCAAACAAGTTTCCATCAAAAGTGTTTTCCCTGATTTGTTGACTCTGACACCGACGGTGGTCGTTCCCCCCCCCCCCCACTCTCTCAATTGGCATGTAAATGACCCCGTATGAATGAAATGCCTTTTGGCGGCATAATGCATATCGCCTAGTACCATTATTAATCTTCCATCCCCCATTGTCTCCATCTATATAGGGGGGAGGATGCGTGATGCGTGAAATATGCAAGTGAGACTTCAAATTGAGCGTGTGAGATGTAGTGGCAGATGGCTGGCTGACAACGGATGAGCTCAGTTCCATCGACTGTATCACACGGAGGACTTGGAAGAGAGCAGGGAGATGGATGGGGGCAGATGGCGTCATCTATGGACCATTTTTTTTGGAGCTGTTCACTCAGATATTAGGGTATTCTAATCCCCTTTTTAGGTCTATTTCTGATCGTAAAACTTGTTCTTTTCAACTCATTTTTAATTCAAAAATTTCAAAAGTTTGTCGTAAAAATTACACAAAAACCTAAATTTTGATCTGATTTGAGGCATTTTAGTCCCTTGTTAAGCGTCTTCGATGCACCATTGTTCAACTTGTTTAAACTTTTTAGTTCCGCATTCGAGGAAAATGGAAAATAAAAAATTTGTAAAAACCAGACTTAGATTCTCCGTAACAACGCTTTCATGGGAGGTCACACGCCCGGTTTCACGGCCTGATGCCTACGTCAAACCTGCCTCACGCTGAGTCGGCCTCACGCTCCATTTCTGAATTTTGGCGAAAAATCAAATACTTGGTCATAGTGAAAAGGTAATTTTTTCAACCCGACACTTTTCGGGTTCCGCGCCGCACTATACATGAGGCGAGGCCCGCGGCGCGAGGCAGGAGCGGAGGTCGCAGCAAGGCAGGCGCGGCAAGCGTTTTTGCTTGCATGGATACCCTAGTCTAGACAAAGCACGAAGTTCTGGCTTCCCGCATAAATCGGGAAGAGTTTTTGCCGAACTTGGCCATTTTGGCTCGGCCATATCTGGGGTAGATTTGGCCGTCGTGTTGCGTGTCGTCGCGATTTTAGTTGTAAAACTAATTATATTTGTCCGTGTGGAGTACACGACTTTCCCATGCGTTGTCCGGCGGGCGCTTGTCGATGCAGCGCAAAAAATTCAATAAAGGCCAGAACCCAGTGAAAAAGATAATTTGCGACACTTATAAATAATGTTTACCATAAAATTTTTTTTTGTAGTTTTGATTTGTGGCTCTCCTTGTTTTAAGATGTGAACAAGTTTCATCACCGCTGTAAATTGGTGGATTTGTAAAAAATTATGTATTTAAAAATCAAATCTTGATTCTCCGGGATAGAAGCATAAATCAAATTTATTACTGTAACATGTTCACTTTCAGTACGTTTCATTGAAATTTTTAGGCTTTGAATTTTAGGGCATCATAGTTTTGCCTTCAAAATCCACTTGCCCAAAAAACAAGCCAATTCCTACTCGGCGGGGGACGATGGTTCGATAGCATCAATCATATCGGTGTGTGTGTGTGTGTGTGCAAGGCGGGGGATGTAGCTGGCGCGCGAAACGAATAAATCAAGAAACGTCTCTATTTCTGCGAGCACGGATTTCGTTGAGAGCCCGGGCGCTCACGCGGTCTAAAGGAGGAGAGGGTAGTACCACTTCTAATGCAATACAGGGCATACTTCTTCCATTTCCATGTTTTTGTACTGTGATAAACCAATTGTTAACTAGCCAGAAGTGGTTCACATGTTCCGTAAAGGTTTGCAGGGTGTACTGATAATGAATGTCTATTGCTCTGTGAGGAGACAAAGAGGCAACCGAGAGCAAGTCAGTTAGGTTAGGCAGGTGACTTTTCAATTGTGACCAGGAAAAAGTACTTTGGGAATTTTTTTTTATTTTTTGGCTACTGGCCAGATTTTCAGGATTTTTCAAATATTTACAGAAATTGATTCTACATTATAATATTTCTGTAATTTTCTCAATTTTCAAAAAATAGCCAATTAATTTTGAAGTTTCGAATGATTGCCGATCACAAGTTGCCGACTCCCAAGAACACCGGCAATTGATGGCCCTTTGCCGGAAATTTCGAAAACCGGCAATTGCCGAAATTGCCCATTGCCTTGGAAATTTCGAAAACCGGCAATTGCCGAAGTGGCCGACTCCCGGAAATTTTCAAAACCGGCAATTGCCGACATTGCCGACTCCCGGAAATTTTGAAAACCGGGAATTGCCGAAGTTGCCGACTCCCAGAAATTTTGAAAACCGGCAATTGCCGAAAGCGCATTGCCGATTGCCGGAAATTTCGAAAACCGGCAATTGCCGAAATTGCCGCTTGCCGGAAATTTCGAAAACCGGCAAGTGCCAAACTTGCCGAATGCTCCGGAAATTTTGAAGACCGGCAATTGCCGAAATTGCCCATTGCCGGAAGCCATTTCGAAAACCGGCTGCCGACCAAATTGCTAGCCGGAAATTTTGAAAACCGGCAATAGCCGAAACTGCCCTTTGCCGGAAATTTCGGTGCGAATACCGGCAACGACCAGTTTCCGACGAAATTCGAAAACCTGCAATTGCCAAAATTGCCGCTTGCCGGAAATTTTGAAAACAGGACACTGCCGAAACTGCCGAAACTCCCGGAAATTTCGAAAACCGGGAGACCGAAATTGCCGACACCCTTTGGGTAATTTCGAAAACCGGCAATTTCCGAAATTGTCGATTGCCGGAAATTTCCGATCCCTGAGTTTAGCCTTTTTCAGCAAATCAAACAGTTTATGATTCTTTTAATTCAAAAATTGTTCTGCAGTGATCTTGCATCACTATTGCTGTGGCCCTCCTTTCAATACAGTACTTTCTACAGTACCACTACATTATTGATGCGTAATTTCCAGTAATGCCATTCGTACACATTGTACCACTACAGTTCCTACAGTACCCTATACAGTACCGTCGCAAAACAATTACCGTAACAATGGAAATCTTATAATAGACTACAGTGTTATACAAAAACTACAGTAACCCCCTTGAAGTTAGTGTACAACTTGTAAATGACGCTTTTTTCTTTGTTTTTTGCTAAGTTCAGAAATTGTAGAGTGTTTTTGGCATCTGCTCAGATTTTCAGAAATTTTCGTGATTCTATAGTAGTCTTTTTAATTTTCTCAATTTTCAGAAGTCTGCAAATTTAAATTGAAATTTCGTGAATAGCTTAAAAAAACTCAAACAGTTGGCACAAATTTTCGTAGATTCATGTACGAGTTTCAGCCTTGTTCAGCAAATCAAACAGTTTTTTATTTTTTTTTGATTAACGTTTTAATTGTTCTCACCCCCTGCAAAGTACTATCAGGTCCTAACGGTAATATTAGCCTACCGTATCACTACATAGTAATCTCCAGTACTTCTGTGCATGCTGTACCCTTGCATCATCATAGTGGTCTTTAAACCTACAGTACTTCTGCAGTAGCACTACAGTACCACTCAGAATCTCTCCATTAGATAGACGGCGTCTCGTATCGTACCACTACCGTAATCCTACAGTACCGCCACAATACCATTACGGTAACACTATGAAAATCTTACAATAACAGTATACAGGCCGGAAACTAAGCCCCCTTGAATGTAAAACTTGCAAATCTCTACCGTTCCTACAGTACCCCAATGCAGTACCACCGCAATACAGTTGGCATAACACTATGAAATCTTACAGTACACTACAGTAGGCAAAAACTACAGTAACCCCCTTGAAGTTGGTGTAAAACTTACAAATGTTCAGCTTTCTTCTACAAATTTGCCAATAACTTGTAAGTTGGGGGAGCGCATCGAACTGTATACATATATGTACATGCCAACCAATTATTTTATCAAACAATTTATTAATAGTCGAAGACACCTGAAGCAACGATTAGGAGGAAGAACACGGGCAGGGAGATAGGCAGAAGAAGAAGAAGAAGACGAATTAGTTGAAGAATCTGTTGAAACGGACGACGTTTGTTTGTGATGTCGCTGTGCGACAGCTTCTCGTTGCGGACGGAACGATGTTCGCACGGCGAATTCGGTGGCGAGATGTCGGACACGTCGATTGTCGACGAGAAGGGATCAGTCGAGACGGTTGAAGAATGCTGAGGAGGAGGATTATGTCGACGTTCCCGTCCACGACACGGGCCTGGGTACAAGTGATACAGACGTGAAGGTTACAGAAGATGTTCACCCCGTTGCGGAGGTATAATAGTCGTTGAGAGGTGGGTGGTGAACATGAACAAAGAACTTAAGAGGCTTCGTTGGGAATGCGCAGGCCTTACTGCTATGTGGTTGTAGAAGATGGTCTTACCATTGCGTCGAGGCACTTCAAAGTCCCCCCACACCTGGAACACAAAATTTTCAATGGTAGTCTCAAATAATATGCAGTGGCCGATGCACTAGGATAAATTGCCAAACAAGGTGCATCGACGCTAAATAATTTTCTTTTGAAATTTCATTTAGAGATGTTTTGCTGCGCAGACTTTCAATCATCTTTTTAGTTTTCCTCTCTAATATCATCAGTGCATCGAGAAAAAATGTTATAGCAGGAGTAAAGAAATTTGAGACTTTACTTATTTAGACCAAAAATGACCCAAAATTAACGAATTGTTTAGTAAGACGTTTTGAACATTTTTCAAAACAAAGTTCTGGCGGTTCAAAGTTCTGGAAAATAGCACATTTTCAGCTAAAATCTAACCAATGTTTTGGGGGTGTGGCTGGGGGAGCTAGGAATCAAAATGTAATGTCATTTTTTTGTGCCCCACTGCCCGTAAATGGACTTTAAGCGACGAATAATAACTGTAAGGGCCACAATATTTATAAAAGAGTTATAGTTATAAATAGAAATTGAGTTCCGCCCGACCGAGAAAAAACTTGACGAAAATTTAGCCTTAATTTTAAAATGGGACTTTTTTTCCAAAACATTGAGCGATAACTCTTTTTTGAGAATTTTACGTGTCATTTAGAGTAAATTCGGTAGATTTAGGTCATTTTTGATTACTAAAAAAGTAAAGTCTCAGATTTTGATACTTTCTCGATGCACCATGATGAAAAGAAAAAAAGAGAAAGTTTAGGGTTAAAAAAAAGAAATCCGTAGAACCCTTCCGACGTTTTGGGAAAGTATAGCAAAACAAAAGATTTGTAAAAAATTCAATTTCAGTAGGTTCCCCCTATTAAATTCTCAATTTGTATCAATGCACCATACATTTTCAGCGTGAGATTTTGTAAAATGGACAGGAATGAAAATTGATCAGGTGTGTATAAAAAAGAAATTGACATTTTGTTTTTTTTTTTGTCAATACACCATGATGAACTTCACGTCAAACATGGTACATCCTGGAAAGGAGAGAGTTTGAAAAATGTATCATTTTATTCTCGATGCCATGAAGATTTATATTAGTAGAAAAACCTTAGCATAAGTGGCATAAAAATAAAGGTGGAGTAGCGTGGGGATTTTGTCTACACTTATTATGATCCAAAACGATAGAATATCTTAATTAAACACTCCAAAATATTTAAGATTTTTCAAAATTTCCGGTAAAAGTTTTGGCAACTAAATATGCTTGAAAAAAATATGAGCTTTTGAGGAAATCTCATCCAAAGCAATGTCGCGTGTTTCGACCCACTGTTTTTATGGTCGACAATGTAGAAAAAAATTTTTTTTTGGTCGACTTTTAAAATTAAGATGGCAAAAACTTAGTAATTGCCTATTTGACAATAAAAAATTTTCAAAATTGAAAAGTTTTATTATGATATTCGATTATTCTGGCACCATGTGAGTATGGTTTGTAGTAATTTCCCCACTGGGCTACTCCACCTTTGCTTAAAATTAAAAAAAAAATCATAATCACAGGGGGATTATTTAATATCAATGAAAGTTTCGATTTTTCCAAATGTATCAAATGCAGTTTTCAGCGCGAAATTTATGTGCAGTACTTTTTCTTCCAATAATATATCCCGAATGATGCATTAGTTATGGGCTACACGATTTGTTAGAAAAACTGGCCATGCTTAAAGGTGGTGAACCGAAACTTGATACTCTGTCTTTTTAGATCCAAAACGGTCCAAGACTACCTATCGAATATTCGTATTAACCTGTTCTGAAAACTTTTCAAAAAAAAAAGTTATGGCCGTTCAAAGTTTTGGAAAATGGTCGATGTTTAGCTAAACTCTCAAATTTTGGCAATCAACCGTCTGTCACAGTTGGAGCTTAATGTTAGAAACAACACGTGATAAATTGCAAAAACATGCCTAAAGGTTCCAACCGCTCCGACACAACCAAAATTTGAATTTTCGCTAAACGACCATTTCCTCTTCCAAAACTTTGGGAGGTCATAATAACTTTTTTTTTTGAATAAAATTTTCAAAACGTCTTAATACGAAATTTGGTAGTTTTTGGACCATTTTGGGTAAAGGCAAAGTATCGGCCAAATTTTGGTACTTTCCACTCAGCCTTTCAAGCAGAGCCCCTTTAAAAGTTTGACCGAGGTCCCAAAATTTTGTAAGTTTCTTCCATGAACCATGATGATTTTGAGCAAAATGTTAGTTTTTTTTTTGTGCTTGAAAAACTGGTGGCAGGACAGTTTTCGGGTGTTAATAAATATTTCGATTCACTATGTTTTTTTTAATGAAACCGTACCTCCCTTCAACACAAGTCTGCACATCCGTTCCGTCTGTGGTAGCTCGGAGATCCCGCCATTCGCCCAACACCTTCCGATTCGTCCATTCTGATCATCGCTCATTTCAACTGTGTACGTCTACTATTTACAAATGCTAGTTTCTTATGATTTATGGAGTCATCCTGACTTACTATCACCAACTGCTAACACGTTGTAGCTGAATCCAAACTGTCCCCGTTTAGACGCTCACCGAACTCGGTAGTCGACTGTCTGAAACATTATATGGGTATCGCAGCGATAATTTTGAAGCCTTACCTTATTATCCGATAGGCAGCTTGCGTGGCATCCGAGCACTTGATAGTGATTCCACCAAATGATACGGTCACCTGAGATTCTTTAGGAACAGGGGCAGAAGGTATACATGCAGGTCAGAAGGTCGTTTGTCGGTTTTTGCACCTTGAATCTTAAAAAAAAACGATGAGCAAGTTATTTTTTATTTTTGTCTATTTTTGTTCGTATATGGTTTTTTAGGTACCATGGAATAAAAAAAATGCTCCAAAAAAAATTAGTTTACAAATATTACTGGTACAGAGAGTGTAGATAGTTAGAGAGTGACTGACCGCATCCGGTGTGGACCCAATGGGGCGGGGCGCGCGGAAGGAGACGATTGGTGTCGATTTACGAAATGATGACAAAGAGGAACGTAAATCGACACAAATCGCCTCTTCCGCGCGCCCCGCCCCATTGGGTCCCGGATGTATGTCACTCTCTAACTATCTACACTCTGTAGGTCCGGTAATACCATAATATGATCATTATGGGCGTCTACATTAGAAAAAAATCGATCTGAAATCACAGATTTTTGGCCTCCCTCATAAATTGAAAAGGAATAAGAGGTTGCGAAATTAGGCCATTTTGGCTCGGCCATATCTGGGGTAGATTTGCGGCGCGTTGCGTGTAGCGTCGCGGCTCCATTTTAGTGTAAAACTAAATGGAGTTGGCCGTGTGGAGTACACGACTTTCGCGTTGCCCGACCAGCGCGCTTGCCAATGGAGCGCAAGAATCAATGAGGAAGGGCCATGGCGCGCCAGAACCCCATGATTTTTAGGGTATTTCGAGGTTGGCAGACGCAATATGCTGGAATCTTTTTGAAAAATTTTTTTTTTTTTGAAAAACAAATTCCAAAAAATCTCCTCATCGATCGAAACATTCTTGGGTGAAAAAAGTTGCACGATTAGGAATTTCAGAAATTAGAAAAATTCGAAATTAGGAGAAAACAGAAAATTTCCAAACTGCTTTCAGAATACTTGTATACATGAAATAGCCTAAAAATCATGAAATTTTTCAATAATTACTCTAAACTAGCCCAAATTTGGTAGTAAATATTCACTGGCAGCAACTTCAGTGCGAGATTTTTCTACTCAGTTTTAAGTGCTCGTATGTCGCTGAATTGTTTGTAGGTACTTATTTGAAACTCTTTTGTCAAAATTCAAAAATTTAATTTTCACGTTTAAATTTTGAGTAGCGCCAGTGGGGGATTTTGTCTAAATACACTCATTATGATCCAAAACTACCTGAGTAATTGCCACTATTTGACAGTAAATAAAACCACGATTTACAGAAAAAAAAAGTTGTATTATGATATTCGGTCACTTTGGGACCAAATGAATGGTTTTTCAAAATTTCCCCACTGGCGCTACTCCACCTTGAAGAAACTGAGCGGAAATACTTTTTACTCCTTGTGAGTATGGCAAAAAACCTTGTACCACATGGCAAAAGAAAACCCACGCATTGTTAGTCATGACAACTTCGGTCTCATTCTCCAAATTGCCGCCTTCTCCGTTCTCCTTGGTCGATCAGCCAGTCAGGCATCTAAGCAAATAATGCCCAAAATTCAATACATCCAGCAAACGTTCAACTGATATTTCGTGTCCCATTGAAGCGTGCCATTTGAATAGATACACTTTGGATGGCCCGCGTTTGTATCGCACGGAAGTTTTCGTCAAACCTGATCTTCAATAGGAATCTGCAATATTGAATTTTTTTCCTTTTGGTGGTGACCTTCAAGGTTTTGGCCTGGGTTTTTAATCTTCCATTAAATCCCTTCAAGTTCGCTTTTTCGAGAGTTTAGTTTCTAGGCCGAGGAACTTCTTGCAGCCAAATTTCTAAACTATTGTGTTTTTGCCAAATTCTAACAAAGAAACATTAGGTCAATTACGTCATATTCTTGCCACATGCAACTTTGTCGTCATAGGCCCACATCATCCGAAAAGCCTAAGCCTGAGCCCAATCGAAGGTCGCTTGAGCCTAATGTTCAGCCTAAGCGTACGCCTAAGCCCAAACTAAAAGCCTAAGCCTGAGCTCAAGACTAAGCCTAAGCCTTAAGAAAAACCGGAAAATCCTAAGCCTAAATAGCGTAGCAAGCTAACGCTCGCCACTGACGCCAAACCTAAGTCTCGGCTTAAGCCAAGGCCTAAGCCTAAGCCTAAACCCATGATTAAGCCCAATCCTAGCGAGCCTACGCCTAAGCTTGAACCTAAGCCTAAGCCTAAGCAAGCCTCAACCCAAGCCTATAATTTAGGCCACCACTAATGTTTTCAAAACTCGATTCTCAAATACTTTTTTCAGGATATGAAAGTAGGACAGAAATGGGCAGGGTATATGGTATGGAGCAAATATCACAAGATGGATCAGAAACATAGATACGGGGTGGGAGTGTTGGACTAGGTGACTTTTCTAAGCCATCCCTACCTTATGTGAACACACGCATTCGAAGTGTCCACAATGGCCACTGATCGAATCAGCGGTGGCAGCACCACAACCACCGACCAAATGATCCAGTGCAGAATGATAAATTTGTGGAGGGAAAAATCGATAACAGTAGGCTCCTGAGGGTAATAGTAGTAATCATACATATATGGAAAAATGAAGGCAATCCAAAAAGATGTGTGCGCTGGTTGGGGTAGTGGCATCAGAATAAAGGTGGGATTGGGCGGTATAATTGGAGCGCGGCCGAGGAGGAGAATCCCAAAAAAGAAGGAAAGTGCAAAGAGGAGAGTAATGACATGTTACGGTAGACAGGACAATGCAACTACCTAATTATATGAAAGAGGGGGGGGGGGCGACGAGAAGAGAAAAGTCTTACGCAATTTGCAATCTACTTGCCGACTTTCAATTTCTGCTAGAAATCGAAAAAAGGAAACAAATTCCAACTCAACTTTTTCGATATCATCACTTCCGTGGCACGGCACACGTCGGAGCAGATTCAACGACGTCTCGCGATCCCGACTCGCTTTACCCATCCCATTGTTCCCCTGATAGTCGATGAGCTCGGAGATGTTGACCCTGAACGTGCGATCGCGGGTAATCGCACTCTCTGGAATTTTGAGAGCTTGGAAGATTTGCCGGGGGGGGGGGGGGAGGGTCTTACGGTGTGATTGAGTAGGATGATTTGTGCCGTTCAGGCGGGTCGGCCAACTCAGCACGTACTTGCCGGGCGTGTGGTCGCTTAGTCTGCAAGGAACTGGCCAAGTTTGAGCGGCCGACAGCATGCGGGTCTTTTTTTAGAGAAGGGGGACTGTGAGGTGTCCGCTGCTTCAGACAATCTTAGCATCATGCAAACCTTGCATCTTTTGTATTTCAGGAAAAAAAACAGAATTTTTTTTGAGCAAATTTCAGCCTAAAACAAAAATCTAACAAAATTTTGGGAGGATGAACTTATTATACCAAATTTTTCCCTGGTCTTTGAAGAAATTTAAAGCCCCGTGGCTTCTGATATTATCAAACAAATTACAGATATGAAATGTGACTGAAGCTTTAGGTCAGAAATACATAAAAAAAGGATTTTTCATACTATTTTTCCAGTCAAATTTGATTTTAGGCTTTCAGATTTATCTACGAAGTCTGTTAAAATAGGCTTATATTAAAAAGCTATCCGATTTACTAGTAAAAAATTATAGCGACCGACATCTCGCAGGTTGTTAAAGAAAAGTGCATTGACGGGCCACGCAACCTTGGCAGTTTATATCTCGGCTGGTTTTGGTTTTATTGGTTAAAAAATTTCTGACGAAATAAGTTTGTATCACTTTTTCTACTAAAAATTTGCAAACACTTTTTGCTAGCAGCGATTAACCGAGATATTACCGGAAAAAGTACATGAGTAACATGGTGCATCGACAACGAAATATCTCACAAAACTCTGGCAGGTTATATCTCGGCTGGTTGTGGTTTTATTAAAAAATTTAACAAAATGTTTATCCTCTTTTCTACTACAACGCAGTTGAACACTTTTTGCTAGCAGTGATATAAACTATGATCGGAAAAAGTTAGATGAGAATCATGGTGCATCGCCAAGAGATATCTCACAAACTTTGGCAGCTTATATCTCGGCTGGTTGTAGTTTTATTGAAAAATTGTTAATTGACAACATATTTTTCCTTTATTCTTTTGCCACAAATTTGCAGATGAACACGTTTTGCTAGCAGCTATAAACTACGAGATATGATTGGAAAAAGTTAAATGGTAGATGCATTGATCAGCTATCATAGCTCATGTTTTACTTATCTCAGGTTTTACCAAAAAATTGCCAATTATTAAAACATTAGCCTTTTTCTTCGAAAATTTTGCTCCCCCGAATTGCCGAAAATATCCTAGATTTGATATTTTTTTGTAGATTTAGGAGCCTTAACATTTGTTAATTTTTTAAGTATTGACCGTTTCCTTTCAAAAATAACTAATCTAATACTGAAACACAGTTAACTTTTTTCATTTCAATTTTTATAATTAGGTTTGAAAATTGCCGAAAACACTGTCGGCATTCAGTTGGAATTTTGGCAATTGCCCCTAGGAATATTTCCGATTCCCACGCGCCCCTGGTGTGAACCTAGTGAGCATGAAGCCAAACGATTTAGAAATCCAGCACAAATAATCCTAGCTTTTTACTATAAACAATCTAAAAGACCTTACCACCAACGCCGTTTCCGTCTTCAACAAAGACTGCAATCCTCTCTGGTGCTGATAAATTTCCATGATACCAAACTTTCCCCACAACATCCTCAGTTACAGTAGGCGCTATTCGACACAAATGACTGTCGATGCAGGGAACCTCAATTCGTCGGGGGCGCCGGCACCGTAGATCCATCGAAGACTTGAAGCATCGCCTGTGAAAGTGTTCACATTGATCGGAGTGGTAAGGACGGCGATGAGTTTGGGCACATCCTCGATGAACACCACGTGGCATCGACGATCCGTTCCATCCTTGTTTTTTGCAATGTAGCCGAACATTAGCTCCGTGTCCGTCCCCTTTTGGCCTTGGGCTCCGAGTGAGAAGAATGAGAAGGGATGACGTTGAATTAGACGACTTTGTTTTGAATGATGATTTTGATCATTTTCGCGAGCAGGAAATGTTGATGTCTACGGTTTCTGGAAGTTTTCTTTTTTCACTTATTCACCGAGGATTACCTGAAAAGATGGTTTACCTGGGCTTTTTCATGGACCCGTGAGGTTGTCGGATGCAATAATTTTGTGGAAATTAGTGAATATCTCTACTTTTATGACTAGCGGCTTACATCATTTAGCGCGATTTTGAGCGACCTGTAAGATGTCGGTTGCTTTAGTACATTCTAGTGGCAGGCTTGGCTGAATTTTACTGGATATATAAGCTATCAAAATTTGAGCATGTCGATGCACCATATTATCTCCTGAGTTTATTTCCATGCTGCTATCAAAAAGTGTTAAAATGCAAAGAGTAAACGATAAATATTTTGTCAACTGACACTTTTTCAAAACAAAACCAAAACCAGCAGAGAAAGTAGTCCAAGTTAAGTCAGATATTTCCGTTAGTCGATGCACCATGAGTAACCTTTCTATAATAACCTGGTGAGATGTCGGTTGCTATAATTTTTTGTCATTAATTTGGACAGCTTGTTAATTTGAGATAAATCTTGATGATATCGTGGCGCGGCCTACCTTTCATATGCGGGTCCTTTTTTTAAACATTTTGCAAAGCTGGTCATGCATTTTTAGTAACACTTACAAATTAATGAGTGTTTTGTATCGTAAATTTTTACCATCAGCCATGCCCAGAAAGGCAACTAGCCTTTTATTTTCTTTTGTTTTTTTATTCCACAAAAAAAAACTCACCCTACTAACAACTGGATTGATTTCTCGAGCCGCAGTCACGCGAACAGTATCTGCAACGTGTTACATTCTCTGAAAATTGATCAGTTACTTACGTAGATTTGTTATATATTTGAGCTTGCAGATGCCTATTACCTGCGTTCATGCCTACTAAGACTACCGTCTGATTTCTAAATTGAATAAGATTTTTTTTTGATTTTAAGCCATAAGAAAAACTAACGAAACAATTCTCATCTCGGAAACCATCACGTTGACTCGACTACTGGATGAACAATGCCGAGGTACTGAAATACAATTTTATATTTTCGGGGAAAAAACTAATAAAAAACTCACAGTAGCCGACAGAGAAACCCCGCTGCTCCGCAGCTCCTCTGCAAATGAGGGCTCCACGTTGAGCATCTCCGCAAGTTGATTTTTCATTCCGACGGAATTCTTGATTATCTTTAGAAAAAATCTAACTCGACATTCGATCCGAAATTTTCCAACGATTGAGTGAATGAGGAACATGACCGGGAGAGAAGAAACGGAGACGCAGGCGGTGAGCGGAGTGGGAGAGAGAGCGCGCGAGACGGAGAGGCGCAGGCAGTGGTAGGGACGAGACAGGGAAAGATCAGATGTTGGCTGATGTAGGTGAGTCAGCATCTAATAAGTTAAGTTGACTCATAACTTTGTTATTTGATCAGACGGGGGGGGGGGAGGCCGTGGCCTAGAAATATCATTGCCTACTTATTCTAACGTCACTAATGGCCTAGGAAACCTTGATAGCTTTTTTGGAGAAGATATGACGTCATCGTGCTGGTGAGTGACTAGAAATCTTATTTTAGTTCTGGAAGAGGACAAATATTCTGACCGTGCAAAACAAATTAATGATGTGACTGGTGGCCTAGAAGTCTCAAATTATACCTGGGGAAATAAATGACGCCACTTGTGGCCTCGAAAACTTAAACTATGCCTGGACGTCACCGGTGACCTAGAAATTTATTTCTGGCCACGTCATAGAAATTTGAATTTTGATGAGAAATATGACAATTTTATTTATGGTTTTCTGAAAATTAGAATTTTATTGATTTTTTGGCAACCGGGAAATTGGAAAATTTAATAATTTGAACAAATGCAAATAAGCAGTTTTTCAACAGTCATTACTTTTTTCCGTGAATTTGATTTTAATTTGTAAATTTAGGTCGGAAAAGTCATACACACCGAGGAGCTTCCCTCATCCTCCCTGGATCAGTCGGTAACTGCGTTTCGACAGTGGGAGTGGGAGGGGTGGGATGAGTTCGATTCTTCTGGAATTCTATAGTTTTTATTTTTGTTTTTTTGCGCCTACATATACCTGTGAAAATTGGAACTCGACACAAAAACCTCTCTAGCGCTTATATTTACTCCAATTCTTCCGGAATTCCATAATTTTTATTTTGCTTTTTTGCGCCTACATATACCTGTTACAATTGGAACTCCGTTTGACACAAGAACATCTCTAGCGCGGGCTTAAATTTACTTCAATTCTTCCCGAATTCCATAATTTTTATTTTTGTTTTGCGCCTACATATACCTGTGAAAATTGGAACTCGACGCAAAAACTCTTTAGCGCGGCTTACATTTACGTTTACAGTCCAAAAAAATCATCTATAATGTTTTTAAAACTAGAATCCAAATCTATCAGATTTTTTTGAATTTTTGATTTTTTTCACATCGAGATTCGAGCGCGGGAAAATTTGGATCAATTAATATTTTCCAGATTTCGATACTCCATATTTAAAGCAGATCACCTGAACGCCAGAATATGATACTTCCTACTCGTCCACCATCTTCGCTTTTGAAAATAAAAAAAAGTCGCCGTATTATATTGATATAGAAAAAATACCAACAAAATTGTTACTATTCACTGATTAGGCATGCAGGGTCTTTAAAGTCAACATTCATAGTGGGAGCTGGAAATACAAACGCATATATAATAACTTGTTAAAAGTAATTTATTGTGGAGTTATAACCTATAGACAATTAAAATAACCTGCTGCCTAAAGAGTAGTTAACAGAAGCAAAGGTTTTCTTAGTGGAGTTTGTCCATTTACTTTTGTGCATGTTATTGAATTGAAATGATACAGTGAAACTAGAGGTAAAATTATTTACTCGGTTTAGGCTTAGGCTCAGGATTAAGGCGCTTAGGCTTCGTTTTAGGTTTAAGATGAGCTTAGAAGTACCGATCGTAACTGATAACTTCTGCAAATTTAGTTTCTGTAATATCGGCAATAGCCAAAATTGCCGGAAATTTCAAGTGCGATTAAATAAATAGAGAAATAAAAATTAGTTCCTAAGATACATTATCTTTTTGCAGTAAAGTAGTAAAACTACTCACGAAATGCGAAATTGCGATGCGGAAGGAAACATTCCTATGGTTCCTTAGACAATTTCTCACCTATTAGGATATAATATATAAATGATGAATTTGACCTTTTGACAATAATTCTCTTCGATAAATGCATTTACTTGTTTTTTTTTTAATGAGTAAAGCAGAGTGTGGAATATACTATGAGGAAGATGGTGAATATTGTTGGAAATTTTTCTGAAAGTTTTCATTTTTTCTGGAAATTTAAAGAGTTGGGTGTAATTACTGAAAATTATGTTTTAAGAAAATTATTTTAATGTTCAAATTTTACAAAGAACTCATTTTTAAATCATTAGAGGTGTAGCCAGTGGGAAGATTGTTGAGAAGATCCACTCCTTACGAAAAGATACGGAATATCATAATAAATCACTTTTCACGCGAAAAGCTATTAGTAACTTTTTACTGTCAAAAAGTGACAACCACTCTGTTTTGGCCACTCATAATTTTGCAACGACCAAAAAATTAAAATTTGTTCTCCTACATTTATTATATACTTCAACTTTGTTTTAATTATTTGTACTTGAAAATTGTAGGGAACAGCATGCGACAATCCTGTCAGTTTTCAAAAATCTCTACTTACAAAATATAGGACACGCTCTAAAAATGGATGTTTTTACATACAACGCCATCCGAAAATCCCTTGTAACGTCGGCACATGCGGTCCTTTATGTGACAGTTGTCGTGAGAAAATTAGAGATAAAAAATGTCCTCAGTGTAATCAGAAAGGCGTTCGTATCGTGAAAGCAATGTGAATAAACAATTTTGGGATTTAATTGGTTTTTGGCAATTTTTAAAACCCCAGGAAATGGAAGTTGAGGAGACTAGGTTGGTTAGAATAGCTCTTTTTCTTTTGGATTTTTCGGTAATTCCGGGACTGCGGTTATCCTTTGGGCCGAAAACTAGGCCTTAGAGCGATAGGACTAAGCCTTAGCCTAAAACTAAGCCTCAGCCTAAAACTAAGCATGAGCCTGAGCCTAAGCCTAAGTCAAGCTCGCGCTAAGCCGAATAAGTCTGCTGCTATCAAAAAGTGTTAAAATGCAAAGTTGTAGTAGAAAAAACGATAAATATTTTGTCAATTGACACTTTTTCAAAAAAAAACCAAAACTAGCAGAGATATAAGTAGTGATGAGTCAGATATTTCCGGTCGATGCACCATGTAACCTTTCTCTAACAACTGTGAGATGTCGGTTGCTATAACTTTTTAGTCATTAATTTGGACACCTTGTTAATTTGTAATAATTCTTGAAGATCGTAGCGGGGCCGACATCATTCACGGGTCCTCTTTTTTTAACATTTTGTAAAGCTGGCCGCATTTTTGGTAGCACTTAATATTACATCAACCATTAATGAGAAAATGTTTTGTAAATTTTTACTATTAGCCATTGCCCAGAAAATGGCAAGGTTGCTTTTTTATTTTATTTTCTTTTGTTAATTCACAAAAAAATCACCCTACTAACAATTGGATTGATTTCTCGACCCCAGTCACGCCAACTGTAGAACGTGTTGTATACATTCTCTGAAAATTGAACAGTTACTTTATTACGAATTTTTATATATTTGAGCTTGCGATTGTGTGATCAAAAATTTTGAAGCATGGTACGTAATATTTGAACGATTTTTTTTCGGAAAATCAATAAATGAAAATGGAGTTTTTTTTTTGGATTTTAGCAGACTTCCCAAACCGATGACTCGGAAAGATCATATGAATCGATTATTTTTTCTTTAATAAACCTGTTCAGGATTTGGCAGGCATTATTATGAGAAATAGGCCAATTAGCCTAGCATGTACGGAAGTAATTTTTGGTAAAACTTTATAAAAGTAATGAAAAGCTGATATTTTCAAAATTCCAGAAAGACGGAAAAATCATATGAATATGCTTTTTTTTTCTTTTTTAAGCCTATTTAGAATTGTCAAAACTACCAGAAAAGACTAAACAAAATAGCTTAAGCTTGATCGGAAATATTACATTTTAAAAAAATAAAAATAATGAAAAGCTGACGAGATATTTCCATTCCAGAATGACGGAAAAATCATAGCGATACTATTTTCTTTTATAAAACTCTTTAGACTTGTCAAAACTAACAGAAAATACTATACAAAGTAGGTTAGCTTAACCGAATTTCTACAAACTGAAATAATAAAAAGATGATTTTTTCAAATTTCTAAAATGACTGAAAAATCCTATGAAGCGATTCGTTTTTCATTCATAGAATAGTTTAGGACGAATTGGAATCATGATCAGAACACATAAATTCGCAAAGTAGGTTAGCTTGACCGGAAGTATTTTTGAAAAAGTGAAAAAACTGATTTTTAAACCAGAAGGACGGAGAAATCAGATATGCAGCGATTCTTCTTTTATAGAGTAGTCAGAATTAGCATTATTATGAGAAAATCGCGAATAAGGCTAGCATGTACGAAAGTATTATTTAAAAATTTATAAAAGTAATGAATAGCTTCGGATTTTTTAAAAATACCAGAATGACTACGGGAAAACTCATATCATAAGAACGATTCTTTTTTCTTGTATAAACCAGATTTCAGAACTGACAAAACTATTAGAAAAGACTGAACAAATGAGTCCTAGAAAAGACTAGTTAGGGAAGAATTCTTAAAATAGGAAGTTGACCAGAAAATCTGGATCTGAAATCTGGAAAAAGTAACTCTCAAAAATTCAAATTTTGATTTTAGGAAGATATGGCTGTGTAGTCTTCATAGACAATCAAAATAAATTCTATTTTAATTTTCAACCATCTTTATGCACGGGCTGATTCTGTCCTTCCTCATTGAATTTTTCGCGCTCCATTGACAATCGCCTGCCACAACGCGTGGGAAAGTCGTGTACTGCACACGGACAAATACATTTAGTTTTACAACTGAAATCGAGCCGCGACGCGAACACGCAACGCGCCGTAAATCTACCCCACGGTAAAGCGCGACATGAACTAGTTCAAACTCTGCGGTCCATTTCAATTTACGCGGAAAGCCAGAAACCCCAGTCGTTTTTATGTAAAAGTTCATACTGAGCAGTTAATTTAAACAAATCAAAATTTGGAAAATGATTTTAGGCTTTGTGCAAACTGTAGCGTCTCACGCGTAAAAATCTGCCAATGAATAAAAAATTTCTTTTAAAATTTTTATAACAGTTATTTGCCCAACTTCCGTTTTTCAACGTTAATCCGTTTCCAGTGATCAAATGCTTACACGGAAATCACTGATGACGTTCCATGTTTGGTTGCGATGTGAATAAGGTCGTTTTTTGCCCGAGAAAAAATGGTCACACGCACACACACATAGCCACACAAAATATAATTTGTATATTTTGTTTGATTCGAGTAAAAAAAGAGAACAGGTATTCCTGCGGCGTCGTTTTTCTAAACCGCAAGAAAAGATTGAGAGAAAGAAAGAGAAAGAAAAAAGATGGGAAAAAAACAGTATAAGGGATAAAAGTGTTTCTGGATTAGGTTTAATTATTAGGGGCGCACCATATTGTCGTAGAGGTAGGGCCCTTTTCCAAAGTTTTAAGTTTAATCGATAGAGCGTGAATACATAAAGAGAGATATTTGACCTGCAAAAAAAATATATGGTTGGTTTCTCATGCCATAAAAAAAATCCATGCAACAAATGAAAACTACACCTGCCAAGTGTCTCCGCCAGGCTAACCTAGTTTTTCCCTCCAAATGTTCCGTGACTGTTGTTTAAGGCTTTGCAGACCGCTTTCCCCACCGCACCCGTGTTAATCTATTCCCGAAGTGTTCTCCCTAGATAATCGGGTTGCACATTTTTGGTGAATCGGCTGGGGGTAATGAAACGGAGTAATAAAATAAATGAATAAAAAAGAAACTCCTTGTGGAGAGGCAATGAAAAAGCAAGCTATGCAAAGTATTGATCCGTTGTTATGAATCTTCTGGGCTCTTAGGCTTAGGTTTTTTTTAGGTTTAAGGCTTAGGCTTAGGCTTAAGCTGGCTTAGGGTTAGGAGGCTTAGGCTGAGGCTCAGGTTTAGGCTCAGGCTTCGGCTTAGGCTGAATCTAGGCTTTGGCATAGGCGTGGCTTGTGCTTAGGCTTAGAATTAGGCTTAAGCGTGGGCTTAGGCTTAGGTTAGGCAAGCTTAGACTGAGAAGACTTAGGCGTAGGCTTAGGCTTAGGCTTAGGTTTAGGCTTAAGCCTATACCTAGGCTTAGCCTGGCTTAGTCTTAGGCTTAGGCATCTCATGTTTAGGCATTTTATGCTTAGGCTTAGGCTTAGACCATGGCGTGGGTATATCCGAATGTGTGTTTTATTATGTTTCTGATTCTGAAATCATTTGTTATTTTAATATCCTACCAACAAACAAGGTTGTCTCTTTGTGCTGCCAGGTGGCATTTCCTTAATCATCTCAAATATTTTTGGTTTCATTTCCCCCCATCGCAAAATCCCTTTCTTTATCTGTCATTTCGCCTCTACGTTCAACTTATTTGATTTTGTGGTTTTCAAGAGATCATCACGATTAAACAACGAATGAAAAAAATAGGTATGGAATTACTACCGTATTCTTTTTTGCCTATCCTTGTGTCTCTCATTTTCCTTTTCTCTTCTAACCAGTTCTGCATTTTGGAATTTCTTCTCCGATTTGATCAGTTAAAGCTATTCGGTTTAAACCATCTTCTATTCAATTCTGATGATTACTGTTAGGAACGAGTGGTCACTTTCAAAAGGTCGAACTGTTGTACTAATTGAATTGGAAAATGCTCGGTATTTGACGTTTATCAGAGAAAAATTGAAGATTTGATATAAAATTTTGTAAAAATGAAAAATAAAGTTTCATTTAGAGTAGTATTCTGGCTTGCCTTATAAATTGTAATGGAAGAGTTGGCCATATTCGGCCATATCTGGGGTAGATTTACGGTTCGAGCGTTGCGTGCACCATCGCGTCCGGCTCGATTTTAGTTGTAAAACTAAATGTATGTCCGTGCGGAGTACACGACTTTCCCACGCGGGTCCGGAAGGCGATTGTCAATGGAGCGCGACAAATTCAATGAAGAAGGCCAACTTAGTGTAGTATTAGCAGACCAGGTTTTCACATAATTTGAGCGGTCTAATGCACATTTTTACGCAACTTTATGGGCCAGTATAATTTTCTTGGAAGTTTTATTTGAAATAAATTCAAATATTTTGAAGCCTAAAAATAATTGCCAAAAAAACAAATTTTTAGTAATTTAACTGCCTCTAAGAGTAATGAACAAATGTTTCCAACTTTTTGCAAATTACTTGCTAAGTTCCCGTGCAAATCTTGTATATAGATTTTGGCCTGAAACATAACAAGCCGATTGTTACAAAAATTAGGAAGGTACAATAGTGTGTTTATTGATCAAACATGTGTTCTTGAAGTTGGGTAAGAACAATTGATGAAGGTTTGGACCAAAGGAAAGCAAAAAATGTTTTTAGAAGTGAAAGTCTGAAACATTACCTTATTTCTGATGGTCGTTAATCAAATTTTGACAGACTGTAATAAGAAACCTTGGCCATCGTATTTTCTTATTAGTGCAACCGACCACTTTACTTTGAGTAAGACGTTCTTGTTTATTGCCTTTTAAAGACCTCAATATTTTAATAACTACACAATCATAGAGAACCAACAAAAATTTTGTTAGTTGACAAATTTAAATAGGACAAACGATAAATGAGCAATGAGCTGTCAAAGTTGAACAATGGTGGTGCAATAGAAGGAACTACTAGAAAAAATACGGGTCCTAAAATAGTTTTTATGTTAAAATCAGAAGATTGGTGGGTTGATTCCAGAAGTTTATTTCAAAATATAAGGTAACTCCGCTGACCGCGCCTCCGGTACCTTCAAAAGGCAAAAAGTAAGACTTTTCTAAAACTACAGTTATCCTACAGTAGGTCCAACAGTACACCTACAGTACCTCTACAGTATCTTGACATGATCCTCTACCTACTCCGAACCCAGTACCTCTTCAAAGGCTAAAAAGTCAAAATTACACAAACTACAGTAATCTTACCGTACTACAGTAAACCCAGTGAACCATTACAGTTTGACATTATTCGCCACCAACTCACCCTAACCCAATACCCTTCAAAAACTAAAACGTCAAAACAAACTTGTAACAGTAATCCTGACACCGTACTCCTACAGTACTCATACAGGACTACTACAGCGGACCCCAAACATATCTCACTAAGCCCCAAGTCCAGATCACTTTCAATGAAGTCAATTTTTCCAAATGTAACTACAGTAATCCTACAGAACTCCTACGGTACCCCTACAGTACTACTATAGTACCCTGACTATGTCTTCGACTAAATCCAAAGCAATATCCCTTCAAAAGACGAAAAGTTAATCTAAAACTGCACGTTACGGAGTCTTCCAGTACTCCTACAGTCCCCTACAGTACTACTACAGTACCCTGACTATGTCCTCCACTAACTTCAAATCGATAACCCTTTTCAAAAGACGAAAAATCATGTCAATTTTTTCTTTTTTTTATTTGAAATTGTCCGTTATTGCCATTATGTAATTTTCCAAAAATGCTGCCATCCTAAAAAACTGTTAGGTTTTTGTTCATACACATTTAGCTTATACACCACCTGCATAGTGACCCATAAAGAACCAACTTGGCCCCTGCCATACTTGGTATACAAAAATCGAGAACATTTGGCAAACCTGAGTGGTCATTCTATTAGCTATTCACCATGTGCTCTAATAAAGTAGAACTGATCATGGGAATATGTGTCAAGGCAGTAAATGGGGGAGTACTGTTAATGTACGTGTGCAATATTCCAGATGCCAAGTATACAGAGTATCTAATGACGGTAATTTGATTTCAGGTGCTTTAGTACGCTATATTGTTCCAAATGCATGATATTTTTTTTTCGAAAATTGAGGTTTTGTGTCGAATGTCCCATAATTTTGGATAATCAGTGGTCTTTAGCGAAATCTTGAAGCCGCTTAAAGCAGTGCTATATTTACAACTGCATTAGCGTTTTATTTTGCTCTGAAAATGACTGCAAATACACAAAATTTTGGATTAAACCGCCTGATTTTAAAACCGAGCTTAAACAGAATTTTTATTTTACAAACCTTAAAAAGTCCAAAAATTTTCTAAATTCCCTATACTAAAATTTAGCGACCCCATCACTTTCTACCCCTTAATTAATTTTTTACTCCATTTAAAAAAAATATTTTGAACCGGCAATTGTCAGAAAATTGGTTGCCTATTCCCGAAAATTTCCAAAACCGGCAATTGCCAAATTTTCAAAGCCGGCAACTGTCAAAATGGCAGCAAACTTCCAAAACCGGCAATTGTAGAAATTGCCTATTGCCAATAATTTAAAACCGGCAGTTGCCGAAATTGCCGAAATTGCCGCAAACCAAGACAGGCAATTGCCGAAATTGCCGGTTCGAAAATTTTCGAAACCGGCAGTTGCCAAAATTGCCGCAAACTTCCAAAACCGGCAATCAATAGCCTAAACCTTTGCCGATTGCCAAAAACAACACCGGCAATTGCCAAAATTGCCAATTGCGCAAAATGTTCAAAAAGATTTCAGAAATTGATACGTTTTATGTCCTTTAATTGTTGTGGGATTCTTTTTTAATAGATTTGAAACATATCATCCTGTTTTCAAGAAAATTAATTCCTTCAGTTTCTGACGACTCAAATCCTCCGCAAATGCCAAATTTATTTTGGGCAAACTAAACCAATTCTCAACAGAATTTTAGAGGTGGAGTATTGCCATTTGGTCTAAGTACACTTATAATAATCCAAAAGAACAGACTATCATGAAAAACACTCGAAACAAAATTCTTTTGGGCGACTTCCAAAATTATGAGTGGCAAAAAGGCTGTGTAAGTGCCACTGGGAATTTTGATGACAGTAAAAACTATCAATTTCAAAAAAATTTTGGAACGTTTTATTATGGTATTAGGTTATTTTGGGAACAAGTAAGTGGTTTACTCCACCTTTAAAAATTTAGCCGTTATACAAACTCCAACTATATCCATTTGATACTTTCCCCTCTACCCTACCCATAACAACATAACAGAAAAATTGCTTGGGAAATTACGCATCGTCGCAGTACACCACACTCCATTTGGATTGATGTCCCGAGAGAAAGGTCAAATCGTATTCTACCTCCTTATTCTAACCATCTCTATTATATCATGCTTTAATGAACGAGCGCCGCCGCCGCGCGCCTAGCGCCTCCGAGTATCGCAAAGTGCGACTTGGTCTGCCACATAACCTGAATTCTACTTTGTTGTATGATAGAATCGGATAGATGTAATGTGTAACAATAAAAAACCACGACGACGACTGAATATGGAATCGGCTAGGTGGTACAAAAGTTTCGGAATGTTTTGGTACCATGGTATGTGTAAGCTCTGTGAATTGAGCCACGGTCTAGCAACGATATTTCGTCGAAACTTTATTCTCGAAAGATTGTTCAATTGAAATTTTCCGCAAAAAACATTTTTTGAAAATATTTTTTGCTAAAAATGTGAATTTCTAGTGCAGCATTTTTTTTTTAATATGAAGTCCAATCAAAAAAAAATCTCAAAGAAAACATTTGAATTTCCCGGAAACCCCAATTTATGAGAATCAGTTTCCCTTTAAAAGAAAATTTCGGAGAAAATTTGAAATTCCGCGACGCCAAATAATTATTTTGAAATATTATTTCCTTATCGGCAAGTATTTTTTTTTTTGAAAACTTTGATTTAACGGAAAACCTTCTGAGAATTTTTGAATGTCCAGTTTAAAGAAATGTTCGGTCGCACGGGTTTCTGGCTTCCCTCATAACTTGAATGGAAGAGTTTGCCAAACTAGGAAATTTGGTTCGGCTATATCTTGGGGGGTAGATTATTTACAGCGCGTTGCGTGTCGCGTCGCGGCTCGTTTTTAGTTTTAAAACTAAATGTATTTGTCCGCGTGGAGTACACGATTTTCCCACGCGTTGTCCGGCAGACGATTATCAATGGACCGCGCGAAAAATTCAATGAGAGGAGGCCAGAACCCCGTGAATTCCAGCAAACCAAAACTTGAAACTATTTGAAATACCCACAAAAAACCACTTTGGCTGAGAATGTTTGAATTTCCACAATTTGACGGAATACTTGAACAGATTCAAAAAATTTTGTGAGAATAGTTGAATTTCAAAAACCTGTTTTCTGAGAGTTTTGGACAAAATCCCTCAAATTTCGGAAAAAATTTATTTCCCTCAAAAAATTTCGAGAAATATTTTAAATTACCGGCATATTTGACATTTTGAACCCCACGAAAAAATTTTTAAAAATTTTCGAAATCCCGGAATAATTTTTTTCACTATAGTCAAAAAAGATCAACTGACTACTTACAAACTCCAGTACCCAGAGCATAACCCCCATTAGCTTCCGATTGCTACAGTAATTTCCTACAGTACTCCTAAAGTCCCCCTTCATAACGTTCCCCTGATAAATGCCCTTTAAAATATGCGTATTATCACATCTCACATGATTAAGACTAAAAGGGAGAGGTGTACCTTCAGATAAATACCCGTTCAATGTTTTTTCCTAAACCAGTTGACTTATAGGTTATGAAGAGAAGACTTAGTGTAAACAATGTCGTTGGAAGTGATATGTTAAGAAGTTAACGGCAAAATCGATGCCAAAACTTTTTCAGCTTTGACTTCTACTGCACAGCTCATTCCATAACCATGAGCTCACGTGCCCTTCCCCCCCCCCTCTATCTTCCACCGCACTTTCATTCCTCGTTGTGGCAACAAACCCATCTCCGGATTCGCCTTAATATTTGTCACAGCACAGGAGTACACTCCTTAGCGGCCAATTCGTAATAGCGTCTACCCAGCGACTTGGCCCAGAAACCTTCCTCTAATCGCATCCACAATAAAAAGGTCTGCAAGTACAAGATTAGCACCCCCCATTGATGTCAATTTATCTATTTTGATTCCATGGAACTATTCCACAATGTAGAAAATTGGGGTTATGGTAATCGAAACATGGTGGATCACCTAACTGCTGGCCAAATCATCATGGTGTCAAAAATAAGAATCCGAGTCCTCCCAGACATCCATGTAGGGTATGCACTTTCCCGCCTGTCCCGCATCTAACCTAACGATTAACATCTTTACAGACCATCTCTCCTCCGGATGATGTTGAAAATGTCGCGCCAGCACCTTTGGAGGCGGGGGGGGTTAAAAAGATTCCAATCAACCACCTATCTTCTCGATTTATCATCAAGTTTGCCCCCCGCGCTCTTAGATTAAATGAACTCTTTTGGCTCAATCACAGCACTTGTTATTAAATCTAGGAACTGCATCTATTTCGAACATTGTATCGTTACAGTTACCGAAAAATGTTGAAAATTTGGGAAAAGTGCCAAAATGTTGATCAAGTCAGAGAGATTCGAAGACGCTTCTAGCAATTTTTTGACAGTACCTGTCCCCTTTCGGTAGATTTGCGGCAATTCTCGGCAGATTTACAGCCGCTTTTGGCGGTTTTGCAGGTCAACTTTTAGCAATTTTGGCAATTTGAAAACTTCTACTTACTTTGCATTTTAGTCAATTTTCTGTAATTTCTGAGAACTTCAGATTTTCTTTTACATTTTTTTCCGATGCACCATGTCCTGAACGCTCGCGCCACGACTTTTTATTCATTATAGCAGGTCCTGTTTTGATGCATCATTTCCCAAGAGCCCTGCAATGCTGGCGATTCATGTCGCGATGTACCATGTCATCAAATGTTTGCACCCACTGCACGTTCCACCGCAACGAGGTTTTAATGCCAAATTTTCTGCAATTGCTCGTCAAAATATTTTTCGACAATTTTGTTAGCAAATTTTTCCCTTGCAAAAAGGTTCAAAATTCTGTTCCAAACACCAAAAAGTCGAAGATCCGCAAAATCTGCACTTGAAACACTATTTTGACAACCCCCGTCTCAGCTTGCTATCAAAAATGCAGCCAGATATATGGGCAGCTTGCATGTGAAACAAAAAAGAGAACGAGAGGCATCAGGGGCTAGTCCTCAAAGTAGATGTGCAACTCTATGAAATCGATACGGTTATGCATGGCATGGTGACAGGGAGCGAAGTATGATGATGATGATGATGGTGGAGAGAGCGCAACGTATGGTTACTGAATGTTTTCGATAAAGGTTATCTTTATGGGGGGGGGGGGGGGGGGGGTTGGGGCAGTGTGCATCGAAATATAAAAACTTTCGTGGAGATACGCTTTTTCAAGAAATTTGTGACACCTTCTTGGTGCATCGAGACAGTTTTCGTGGCAAGACCTGATTTGGTTGAAACTCTGAAGCCAAATCGCGGTCTACGATTTTGTGACCAGGTCAAGGTTTTCGTGGCATGGTGCATCATAGTAAAAATTAAAATCCTGGGAAAAAAAGCTCTATATATAATAGCGAGCCATGGACCGTACCTCCCGCGTGGCCCCCTTCTGGAGCTAAAAAATAATTTTTCTAAAACTACCGTAACCAGACTACAGTATTCGTACCGTACCACGATATTGTACCACTACAGTACCTCGACGCTATATCCGACTAACCCCAACTCACTATTTATCCAGAAGCCAGAAATGTGACTACAAAGACTACATAGATTACAAACTATGAACACACGTTGTGAATAAGCGCTTCACATAAATAGTGACATGATGGATTATTGAGATCCCATATGTGACATGGTGCATGGTGACAGGCATTCTGGGAGGGTGAGCACAAAACAAAATCATTAGTTATTTTTCGCCGACAATTTCCAATACAGCGAACTTTACCAAGGTCGTGGCCTACTTGTTTCCGTTACAGTTTCCTATTGTTGCATATTATACCGCCAGTAATCATTGCGTTATCACAGTTGACAACGGTTTGATAATGTCACAAAGTGTGGGGGTTTTGGAACAACAAACCAGCATACGATTATTAGAACGTGATAATTATTTTACCTGAACATCAAGTATTATTAGGTGGTGGAGCTGGGAGCTTAGTATTTGGGTTTTGAAACAATGCACCATGTCCTAAAAGATGCTTTATTGCTAGGTAGGGTGCCGCGACTGTATCCATTCCTATAACAGGTTCAGTTCCGATGCATCTGCTATGAATTAATACTGTTCTTATTCTTAGCTCAAAATCAGGCTGAGGCCCGCAGGCCCGAACACTTTTGGAGACTGTGCAGCTTTAATCCCCAAAGGCAAATTGTTATTCGCTCAAGCCAACTCATCTCTCCAGATTTCCACAAACTTTAATCACTCATATCTCTCAAAACCCTAGACTTCGATTTTTAATCCATAGTCGATCCCAATTTTTAAGGAAATCTCGAATATCCCTAGCTCAGGTTTGAGGCGAAGCAGCTGAAGCTACCTTTTTGGGCATCCCCATTCCAGAAACAGACGATAGCTGGCGTGGCCCTGCCGAGCTCGTCATTTGCCAAAACGTCAAATTGCTGGATCATGTCACGATCCATAATGCCTTGAACGGTTCTTCTGCACCTAAAATTAGCACTCAACTGGTTGAGGTAATACATGATGCAAGACCATGTCCCAAAGGGTCCTGCCATGTTGGGACATGTCACGATGCACCATGTCCTGAAAGATCCACGCTGGAAAACTACATTGTTCCGAGTGTTTACCTCTATTTCAATACGAAATGTCAGCAAATTTTCATCCAAACTCATGTCATTCAAACAAGAGCCTCATGTGACTATAGGGTCGTGACTACCTGCTCGAGTTCGCCTCAGCCCTGTTTTCAGAATAGCTATGCGTTAAGTACCCGATGTATTGCAACTGTCACGATTTAACGCTTAAGTTTTGTAGTTTTGATGGAAATTTTTGAGTTTTTCGTTTTTTCTTGGCTCAAATCTGGGAGAGTTTTGCTTTTTTGACGATTAAATATTTCATAGGGCAGCCCGGCATTTCTTGACTGATTGTGCGACATGATGGTGACAGGGCTTAATCGTCGCGAGACATCCCTCTAGTACAAAATTCTTTTAATATCAGTAAAAGCATTATAATCCATGTCTATACTTATTTTATGGAATTTTCATTAAAAAAATCTGAAATTTACGAGATGATCTACTCCAATTATAGATGGGTTTCAATCCAAAATTTCTCAGAAAAACTAAAATTAATGGGCATAAAAATGTTTTGTCTGAAAGCCCTAGATTGTCAAATATCCCTAACACCCCAAAAAACACCAATGTACATCTCCTCTCCGTAAATATGTAGTTTTACAACCGCCTCTCTGTTGACTGGGAGCCATAAATGTAGATATATTATCTTTCCAGATCGCCTGCCGGCCCCTCCCACCTGATTGTAAAACTGCTCTTTGCTGTGGCGGTTTATCGACTTGTTTTTCTTATATATTCCATTCTACATGCACCTTAACACATTTTCTTGTTTCTATACACTTTTTTAACTATAAAAAAATGCAACTCCTTTTCGATTCACGATCTTTTTATGCAAATCTTTTGGCTTAAAGCTGGAGTAGCACCAGTGGGGAAATTGTTAAAAACCACTCCTTTGGTCCGAAATGTACTCCGAATATCATAATAAAACTTTTCAATATTGGAATTTTTTTCTTCACAGTCATAAAGTGATAATTACTCAGTTTTTGCCACTCATAATTTTGGAAGTCGACCAAAATGTTTTTTCTAGATTTTTTATAATGTAACTATTTTGTTTTAATTATTTTTATGAAAACATTGGCATAGAGACAGGCGGGCCAACATAAGATATTGCTTTGCCTCAAAGGCTCATATTTTTCAGAATTTTGGCAATTTGCCAAAACTTGGTATTTAAAAATTGTTAGAGATAACTGTATTTAAATTGCAAAACATAGAACAGTTGTATTTCAAAATAGTTCGTAAAAATTGTCTAGTTTATTTTGCGGCCACACTGACCCCCACGATGCACCAGGACAAATTGCATTTTTTTGTTCAAAAGCTATTGTTTTGCAAAGGGGCATGTTCCAAACATCTGACCCAAGTTTTCCCGTAGTTCTTCTCTCCCCCAGCGGGGTAAACACTGCACTTTACGACTCCGCCCAGTTTTTTTTTTCGCACAAAGTGAGAGAGAAAGAAACATCACTGCGTCACTCTCCCCCAGTCTTACGCTCGTTCCCGCCCCCCTCCTCGATCTGCAAGCCAGACCGTCCTGATGATTCGAGGAGCCATTCCTTTTCTTATATGTATACGTTTTTGGAGAGGTGATCTTGTTTTTTTTGTTTCTCCTTTCGTTTTGTTCTCTATGCTCTGATAAGAATTTTGTTCTCCTACTTTTCTACGGTTTTTTTTTTTATATCCAAATTTTTGAAATAGAGGGTTGATCTACATGACCCCCATGCTTAGTCTACTATAATGCTATATCTGATATTCCGAATGGCTGGTAAGTGAAGGCTTTTAGCCCAGTGAGCCGGCTTACCAAGTCTGCCTAAGGACCATGGTTCTTTCAACTTAAGGCCCAAAATAAGCAGGGATTCTGGCCTAACCCCCACTAAATCTGTAGGCTAATATATAATTTCTATCATACTCCATCCTTCTTTTCTACCTCTTATCATGTTGTTATTGAGCAGCAACCCTTATATTGTTTGGTATATAGATTTGATATAAAACCTCGTAGTAAATTTTATTTTACACAACAATCATTTATCATAATTTTTTTTCATACTATTTTTTTGCAGAACGAAAAAAAAATGCTATTCACAACATCTTGAGCACTGGAGCTGTTATCATCAAAAAGGTGCATCGCAGCACAGCGGGAGCGTGTCATCCGATCAGTTGCTCAAGGCTTTCGGCGAGCTGGAACTTCCACTGAGCAGCTTCACAATGACAACACAGCAGCCCTGTACCACTCCTGTGCAACATTTCACAACACCCAAATTACAGACTCCAGTCAAACTCACCGTGCAGACCGTGTCGACGTGAACTCAGAGCCACACTCTTCAAATTGTCATCACCATTCATTTGAGCATCCGATATGCGCGAACGCTCCGCGGCCGATTAGGAGTCAGCGAACGCCGAAGGAAGACTACCACACTGTACGATCCGAATGAGCTGGAGGAGTCTATGAAGCAGAGCGAGGCGTGCATTTTGGATATCAAGACATTCATCACACAGTACTCGTTGCGGTAGACTACGGTAGTAATGATGACAGGTTAGTTCCCAAAAAAGTGTAGTGGAAGATTTTTTCTAAAATCTAAGCCGTGACCCGCGGAAATAAATCAGAATACATCCCCGCCTAGTTACCTAATCTCTGGTGTTAGCCACAGTGCAATTGTGTATTACTGTAATTCCTTCTATGACGTCATATGAAATAAAGTTGGCTAAAGGGAAAAGGGGACTCTGGATCTTAGGCGAGCAATTCTCTGCAGCCGGCACCAGAATCGATCCCCCGGTGCCTGGATATCTATCCTTCTGGGCTATTAGCCACTGCGAAATGCCCCACCCGCGCTGAGATCGAACAGGCGTCTGAATTCCTAGGCGAAGTTGCTACCCGCGCCATGTAAATCTCCCAAATTTCCAGGAGTAAGCCAGCTGTACATTTCAAAATTGCTCAACGGCAACCACCGTGAACTATCGCTCCGTCGCCGTAAGAACATCTACGGTTGGTACCTGAACTGCCGACGTCATCCCAACAAACTCGCTACTTTCCTCGCCATGTCGATCCGGCTACTCGCCTCGAGAATGGAGATGTCGAGCTGATCCCACAACGTCGAGAACGCTACGTGTTTCGTCCAAATTTCTTCTGATCCGAATGCTAGAATCGTTCTTCACACAAATGCCATTAGATCTTCCACGGCGAGTCTTACGAAATAGCGAATGCTTGCACTCACGTTCTGATGATGGATAAGAAAGGTGTTGGGTCCATGAGGCCAAAGGAGGAGGTTCAGCAGCCTCAAGTGGTTTCGAATTGGTTTGCAAATAAGCGGAAGGGAGTTGAGAAGCCAGAAAGTTCCGCTGAAGCTTTGGCCGCCTCCACCTCGTCAGCTTCGTCTTCTGCGTCATCGACATCATGATTCTGTCAGGGTGTCATCAGCATGAGCCCTCGCGAAAGAGGTGAGAGTTTTAATTTCTCGGCCACGCTGTACTCTGGGTCGAAGAATTTTTTGTAGGTCTGATAAGGAATCCACTCCGGTTTTCCCACACGTTAGGTCATAAACATGTACCATCTAGAGGTACTTAAACTTCTGGACTTTTATTTACTTTAGAGTATGGTAAACCTGTCAGTCCTTGTCAATCATGTGTCTGTTTGGTCTCAAGTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTCGGTCTAGGTCTAGGTCTTGGTCTAGGTCTAGGTCTAGGTCTAGGTCTTGGTCTAGGTCTAGTTCTAGTTCTAGGTCTAGGTTTACTAGGTCTGAGTCTAGACACAAATGTCTAGGCCACGGAAATTTCTGCCGTCGCCTAGGATTTAGGCCATATTCTAGGCCATGATACAAAAAACTTTCCCTGTCTCCTCTGGAGTAACCCATTTTGAAACAGACAAGCTCCCGTAACACAACCCCGGACAGCAATCTCCCCGTCTCCAGCAGTGTCCACTTTTGAAGTGTCCCGCCCGTATGCCATCATCTCTGCCATGTCATCAACAACCTCGCCAATCTCAATTCCAGCACAATCATGATCCATCAGTATCGCCGCCAGCTCTCGAATTTTTCGCCATGGCCCAACGGCTTGGAGTTCAGATTCGGTTCCATTTCCGACATTGCCAACACACATTTTCCCGTTTCAAATGGCCCCTACGGGAACCCGGCTTCTATTTTGAAGTCTGAGTTAAGCATTTCTAATTTTCTTTTCCTCTTTTACACCAATATCTTTTTTCCATTTGTTCTTATTCATCCCATGACAGAAAACCTCATTCTTTCATATTACAGGAATAACGATGCTCCGTTTCTTACGCCCTGCAGTCCCCACACACCCGTCGTCGTAGCAAAAATCACTCAATAATCGATAGGTTTTTCATAATATTTACTTTGTTTCTTTCTTAGTGTGTTTCACTGCTGTTTTAATATTTGAAAAGTACGAGTCTTCAAAAACTCTCCATTTTTTGTGAATAATATTTGCAATCCACAGCGTAATTCGTAATGTATCGCTTGCCCTACGACGAAATTTTATTGGAAATTCCATTTTTTGTGCAATTTTTGTTATTTTTCAAGCGAGAATAAATATTTTCTCGTTCTAGAATTCAATTGTGAATTACTTTGCAAACGCGCCCCATTGCACTTCCGGGTGAAACAAGTTCGTGTTTTCAAGATATTTTAAAAACTTGAATTTGGAACAACACAGAAATCTGGAAAATGCAACAGTGTTCCAAGTCTTGTCCACGTGTGATACGAGTACACAATAATTTTTCATCTATACGGACAGATTTCAAAATTGGAATGTTTTCCATTTCGTGTGGTTTCTAGGCCATGGGAAAACGAGCTAGCGGCCATCAAAAATTCCAGGTGACCTGGAAGTTCTAAAACTTTGTAGAAACTTGTCCACGCGGAGTACACTATTGAATAGTTTATCAATAGAGCGCAAGTAAAAGGATAATCGAATTTCTTGTCCTTTCGCCACCCCCTCTCCATTATATATGAGGTTTTTTCCCTCGCAATTTCCCACGCTCAAGAGGGTCGCCGCCATTTTTTTTTTGAGGGGGGTCGTATCTAGATTAAACACGTTCATTTATGCTCAAAATGTGCCAATAATTTTTGTTTTTGAGTTTCTAGGCCATTTTGGTAAGTTCGCACACTGACTTTACGACTTCCAAGGAAATGGCCAACGTTAGCTTATTTTTCTAGGCCATATAATTTTTTGAGTTGCAACTGTGGCCAATGTTTTTTTTGGGTTTCTATCACTTGTGAAAAGTTAGGTCATAGAATAACATTACAGTAAACGGGTCCTCAAGGGACAATCAGGAATTGTAGCCTAGTTTTCCTAGACCACATTTGATTTTTGTCTTTCTAAGCCTGGTTTGGGTCTAGCTCTAGTCCTAGGTCTAGTTATAGGTTGGTCTATGTCTAGGTCTAGATCTAGTTCACATGAGAAACAAGAATTAGGCCACCTTCCCCCTAAACTCTATTATCTCCAAACTACTACTTTCTAGAAAACTCTAAAATCATAAAACCAATTTTTTATCACTATTTTCATGCTAAAATCCAATCAGAAATTTGATCAGATACACGCATATAAATATTACGACTATAAATTCGTTTCTTTTTTTCATTTTTCCCTCGATAAGGCTCTCGGCGAGAAAAATTATTTCTTCTTCTATGTGTCGAGACATGTGATATTCCGGCCGGCGGTGGCTCTGAATCAATATTCAATTGAGCGAGAAATATATATTCTCTCCAGAAGGCGTTTATATAATGTGTTCCTCCTGTAGTTTCTGCTGTATTCGGCGGATTTGGTATGCTTCTCAGTGGAGTGCAGTTGCAGCATTTTTTTTCTTTAATACTAACTTTTTGTCAAGTCTTTTTTTGGGATCCCTAGAACACTAGAATTTCTCGCTATTTTGAGATTTCTAGACCATTCTTGAGATTTCTAGGTCATATTGTGAGTTCTAGTGCATTTTTGGGTTTCACGGCCGAATTGGAAGTTTGAGGCCATTTTTCGGTCACATAGGCCACGAATTTGAGGATTTTGTGCCAAACTGGGATTTCTAGGCCATCATGGGATCTTTAGGCACGAGTTTTCCAATCATAATATAATTTCTAGGATATCTTGAACCTGTATTCCTAATGCCACTTTGGAATATTAGGCCATCTTGGGACTATTTCTGCCATGATTTCTAGGTTAATAACTGGCAATTTTAGATTTGGGCTTAATCTACAGGAGGACATACTGCGAATTATACACGAGCCCACGGTTGGATATATAGGCTATCGTGGGATATCTACGCCGATATGTATGGAATCCTAGGCCAACTTAAAATTTCTAGGCCACTTAACCCCGGGATTTCTAGGCCGACCATCACGCCTCCTAAAAGGCACAGACGGAAAGTTCAACACCCACCACCAGGATAAAAGTGTTCGTGAATTAGTCAGCAACACCCCATTTTTCTTCTCCAAAAACTAAAAAAAAAGATACCCCTGACAGATATGGGCAGAGATGAGGGTGCGAATCCTGAAATTGCCTAGAATTCCGAGCTTTTTGTGCCAGACAAAGTAGAGCAATGGAGAATGTGTGTCGCCACTTCAAACACCATTTTGTCCGTTGCTTCGCCCGAAGGGCCCGAAAATAGGCTTGAAAAGCTGTGGCCTAGAATTTTTTCTCAAAATTTTTGACGTGGAAAAATTGCTTAAGATTTTCGAGGCCAAGAGGTGGCCTAGATTCAACATTTATTGGCAATTCTTATCTAGATCCCGAACCCCGACCAGCCAGTTTTTAATTCTCCTCCGGTGTCTGAATTTTTAATTAGAAAAATTATTTTTGGTTGAGGAGCTCTGTTTTTTTTTCGTCAAAAATTGAAGGTGGCCTAGCTTTCTCATTTTAAGGCCACGAATTCTAGTTAATTTTTTGTTGGCTCATTTTTTGTTTCAAAAAATGAACCAGTTAGTCAAAAAATTCTTTTCTGCATATCAAAGGCCACTATTTTTGAGGTTCTTTCCTGCACAATTTTTCGAAGAAAATTTGAATTCCGGAAAGTTTTCTCAGAAAATTTGAATCGCCGCCAAAATTTTTCTCTGAAAATTTGAATCGCCGCCCACCCAAAATTTCAGAAACCGTATTTGAATTCCTGCAAAGTTTTCAAAATGGGGTCTCACCACAGAATGGTGACAGCGCCCACATTTCTCAGAGACATTGGTTTTTAGGCCAAAAAAATAGTTTTTTTGACAAGACAAAAACATAGCAAACACTTGAGCAGTTGTCATATGTCTGTTGCAAGTGGAAAAAATAAAACATCTTTCCTTTTTTCTGCTTCTCCCCCTCCGTCCTTTTTGGGCTCAAAACTCAAATGGGTTGCTCATCTCAATTGTCTGACAAATTAGCAAAAGATGAAGCAATTTTTCCCTGTTTATCTTTTTTTGCCTCCGTTTGGCTCCTATGTCTTTTTTAGTAGTTTTCAGAGGTTTAATATTGAATGTTCAAACTGGCTAAAAAATTTCGATTTTTTTTTCTTTCTAAACTCTTACGAAAATTCTGATATAGGTTAGAAAATTTGCCTTAAACAGATCGACGGCCGACAGCGTTTACATTTGTGGCCTAGACTTCCAAGCCTGGGCCATGGCAAAAACTTGTTTAACTAGCCTACCTTTTCAAATAGTGGCCACTCTAAACTATTTCTGAACTGTTTACTCAAAAGAGAAAGTTAGTGGCCTAACTTTCTCAATGGTGGCCTAGAAAACTCCAATTTTGGCATTCATGACCGGTCATCAACCTGACATTGATGGCCATGCTAAAAAGTTAATGAGTGGCCTAGAAAACCAAAATATGGCCATGCGCTCAGCATGTTTCTAACTTTCCAACTCTGCTATAAATTCCTTGGGGGAAACCTCGGCCATCACGGGTGACCTAGAAAACAGAAATTCGGCCAAGACCCCGTAATTCATGGCCTAACCCTTTAGACGTTTGACTTTGGTGGCCTAGTTTTTTGTGATGGCTAAGTTTACAGAAAAAATCCTCAGCCACAACCTTTACCCTATACATGACATAAAAATGTCCATTATCCAATTAAATTTCCAATTCTCCACCCTTAATTTTTCATTTTGTTCTCTTCTTTTATTTTGTCACTCTCTCATTCTGAAACTAATCTTTTCAATTCTCAGTTTTTCTGGTGTGGTTGATTTTCACAGCTTTGCTCCCGCCATTTTGCAATAGGATTATCCGTGACACAGGCGCTCACATAGCTCAGTGAGCAACACCAACAAAAGCATATATAGATATACAACGATATCTAACTAGTTACACCGGAGCTTCTGTTGTTCTTGCCCCTCCGAGCCGAGACAAACTTTTGGAAAAGAGCTAAACAACGCTTCTGGAGCCGACATATTCGAATGGAAAGAGACAATTGCGACCACTATGAGGAAATGATGGTCGAGGAGGAAATGAGAGATGGCGTAGCTCAAATTGCGCGACGAATGCTCCAAGTTGGTCTATACGGTAATCAGTGAGTTTTTGTGTTTTGTTGGCCGTAGTAGAGATAACTAGGCCAACTAGGTAGGCTGACGATCTTCAGTTTGCAAATCCTCTTCAACCGTACTTTTTTGAGCGATCTAGGTTTGCAAAAGGTAGGCCGCCTGGTCCACCGTACCTGTCAACTTATGATGGCAGAGGTTTTGTCTGGGAAAGCTAGGCCACCTGTGTGAGCTCATGGTCCAAGGTCTAAAGTTTACAAAAACTCTTCCACCGAAACTTCTAGGGTGCTCACGACCGAGGCTTGCAGAAAGGCCACGAGACTTGGCTCGTGGCCCAGAATTTTACTCATCCATCGTAAATTATTAGAAATCCGCGAGGAAAAAGCTAGGCCATCAAATTACCTTAGTGGCCCAGAATCTATAAAAACTATCCCATCGTAGCCCTCTTGCATGGACGGCTGAGCTGAGGTAGCTAGGCCCCGAGAATAGGCCAGTGGTCTCGAATCAACACAAACTCTCCACCGTACCTCCTACAATGGCCGAGGTAGGGAAGATGGGCGCCAGGCTAATCTAACTTTCCTAGACTGACCTAAAGGGGAAAAAACAAGGCCACCGGGTTTACGGAGTGGCCGACTGCGAAATTTCACAGAGACATTGCCCTGACTATCTGACTGATTTTTTACCGTCGAAAAATTCATATTTTCTATGCCAGGGGCCCCCTACGGCCCAATCCTCGCAATTTTTTTATGCAGATATCTAAAATCGCACATTTGTTAAAGCTCTGCACACTAATCAAACTTCTCGTCTGCTGGTGGGCCGTTGCTCCGCAAGTCAACTCCTACATGACGCACAGTATGGGGAGCAAGAGTTCATTGGCGCGAATTTGTCAGATCCAGAGAAAATTCAAAACTTAAAATTAGCAGATCTTAAAATGTGATTCTCTAGGGAGCCTCCCGCTTGAGGCCGTGGACGCTGTAATTTTCGATATCCGACTTTTCCATTACCTATGGGGCATTCGAGGATGTGTGGCAGATTATTTGGATGGCGGTGGGTACTGTTAAGTTTCCCTACGAATCTATACATTTTTCAGGCTTCGGGCGACTTTTGTGGTGCGTTTCCTGCTTAACCCTGGTTTTCTCCATTCCGGTCCTCTTCATCTCCCATCCGAAACCCTGTCTCTTTCGGCCGCTGCTTTTTCAGGTGAGTTGGCTGAAAAAATTTGGAAAAAAACTTTAAATTTTATCCGAAAGGCGATAAGCAGTGGGATTTTCCACGACTACCACTCACAACAGCATGGTTCGACCCAGTCCGCGTGGGTGTGAATTATTTTTCTAGTTTTTTTTTGAAGTACGGAAATTGTATTTAGCCTTATCTGAAAAATTCTAAAATATGCAAAAAAATCTCCGATCAAACCAAGTAGTATCCTTCTCCAAAAAGCGCAGCAACGTCAAATGGTCCCACGTGGGGCCTGAATAACGGCAAATTTCCTGACAATTGACGGGTTATCATCCACCACCCTCATCCTCTTGAAGGAACATTGACTTTTTCCGTTGAAATGGACAAAAAAATTGAAAAGAATTAGATAGATGCGGGAGAATGAACATGGTGGCCTAACGTGGTGCTTGACCCATGGGCTAGAAAACCAAAACTCAGTCATCACCCTGATTGAGGCCATGAGATTAAGCCACGTACGACGCAATCCTAGGCCACCACGTTTTCTCGGCCACAGCCACCCCAAACAAAAATCTGAACTTTCTGATCCTTTCCATCTCTAACCAACGTTTGTTTATCTTTTTACTCGCTCCACAGGAGCAGAACTTTTTTCTATTTTGAAATCCACAAAAGAATCCGGGACAGACACTAGTGTATTTTGTTTTTTATTCAGCCATGAGCACAGACCAGAAATAGGATTGTATCTCGGACTTCAGAGCCTGGAAAAAATCGGAAAAAATCGGAAAACAGTGGAAGAACTGAGTTGGGTGCTAAATTTGGCAACTTGCCAAAATTTGGGGATAACTTTTTCGGTAATCTGTAACTACAGTTTTCCTAAAAATGTATGAACCTTTTAGTGATTACTGCATAGTTTTTCAGGTCTTTAAAAATGAACCTACAGTAGCCCGTACAGTTCACAGGATTGCAAAATTCCAAATTGACCACTTTTTAAGAGTGTATCTCGGCAGAGTATTGGGAAAGTATCGGAATATTTTAAAAATTTTGGATAATTTTTTTTTTATTTATAATTAATTAACATTTAGCTTTCAAAGATGAGCAATGTATTTATAGATACCCATGCAACTTTGAAATAGTTTGTATATCCGTTCAGTGTAACTATCAAAAAATTTTCAACTACAAAATTACTTCATAGCAAAATTTAAAACAAAGAAATTGTTAGTTACTTTTTAATAAAGTACAACCGAGATATTTGTCAAAGTTGAGCTACTTTATCGGCAACCATAAGTAGCCCCCGTACAATGCACCATGTGGTAGAAAATTTCGGTTTGATCTACTTAAATCTACAAAAAGTGCGGGAAGTCGGAGAGTTTGGATAGCTAAGAACGTGCTGAAGTGTTTGCACATTTTGTTGGGCACAAAATTCCCACTTTTCTGATTGTAGATCAAACCGTCGCGGGACAAACTGGTACCTCTTCGTTGTTGGTATGTAAATTTTGAAAATCACTTCGTTTGGTTGGTATGAAACTTTAAACTAGAAAAAGCCCTAAAAGTTGAGCTAGGCGCTCAAATTGGGTAGCATTTACTTTTTTCAACAAAAACATTGCTGGCCGAGCTTTCTTTTACGGCCACGTTGCAATAAAAATCCAGGAGGACCATGTCATCAACAAAAGTACAAGGATGTAGCATAAACAATCACTCCGAAACTTTTGTCGGGCACTGCTTTATCGGAAAAAAAAAAGGATCTCTCCGAACACATCGGTGTCACCCCCAGGGTTCTATAGCGTCTCCCTGACCTCGCGAGCTATTTCCTCGAGACAAATCTCTCTGAATCCTTTTGTAATGGTTGTTTCATGTTCTTCTTCATCTTCTTCTTAGGCTATTCTTCGCTGGGATAAGTAGTAGAAGAAAACCAAAAGAACACATAAAACACAGGCACACACACACACACATTCACACCGTAATATCATATAAAAGTGTGGCTGCGTCTCCCAGAGCGCCCTGGGGGTAAGCAACGCGGGCGCCCGCAAGGAAAAAGTGCAAAGAAATTAGAGAAAAAAGACCGTCTCACTCACTTCTCGATGCCTTTTCTTCTCTAACTATAAAAATTGTCAACTGTGGGGCCTCGAAACGAACGAAAGCGAAAAAAATCAAGAGAACTAGACTCTGAGAGAGAGACAGAAGAAAGAGTTTTTTTCGACGCCGACCGCAGCTGCCAAGCAGCAATAATGACATGCTGGAGAAAAAAATTCAAAGTTTAAATATGTTTTGGCGATCAGAAGCCTAGACCATAAGCCCCTTGTATTGAGTTTTCTCGGCCATTTTTGGTACGGTACATATACATAGAGACTTCAGATTGGGAATTGCGAATCTGTTAGAGTAAGAATAGGCCTAAAACATTGGGCCTAACGGTGACGGAGACTAGGCCTTGTTGGGAGCGATTGTTAAACTATGACATTGCCTAGAACCTCGTTCTATCTTGGTTATGTGGTGTCGGGCTTTCATGATCAGCTCCTTTACTTTTGTCCAGAGAAGGTTTGGGCTTTTTCTGTGGGTGCTTTGGGCTCTATTGTAAATAGGTGATCTTGCGCAGAACACAACGTAGATCTAAATTCTTGTCTAGGCTCTGCAGGCTCCTGAGGGTAGCTGTTTTGCACCCCAAAGCAAAATGATCTCAAAATTACACGACTTCAAGCAGGAGGATTTTTCGATGATTGCCAAATTTTGTAACTTTTATAGGCTTAAGCTTATGGTTATGTTTAGGCGTAGGCTTAG 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####################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################### +V 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#tag_depadded.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,11 @@ +@HD VN:1.4 SO:coordinate +@RG ID:UNKNOWN SM:unknown LB:UNKNOWN +@SQ SN:CHROMOSOME_I LN:102 +I 16 CHROMOSOME_I 2 1 100M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC PT:Z:27;28;+;STOP;Note=tag1 +II.14978392 16 CHROMOSOME_I 2 1 100M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC PT:Z:27;27;+;PRIM;Note=tag2|28;28;+;OLIG;Note=tag3 +III 0 CHROMOSOME_I 2 1 27M1I73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTCAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ###########################"##@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC PT:Z:1;1;+;COMM|101;101;+;COMM +IV 16 CHROMOSOME_I 2 1 100M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +V 0 CHROMOSOME_I 2 1 100M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +* 768 CHROMOSOME_I 2 255 1M * 0 0 * * CT:Z:+;STOP +* 768 CHROMOSOME_I 28 255 2M * 0 0 * * CT:Z:+;COMM;Note=consensus%0Amulti%09line%0Atag%0A!"#$%25^&*()_+<>?:@~{}%7C%0A1234567890-=[]'%3B#,./\ +* 768 CHROMOSOME_I 101 255 1M * 0 0 * * CT:Z:+;STOP
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#tag_padded.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,11 @@ +@HD VN:1.4 SO:coordinate +@RG ID:UNKNOWN SM:unknown LB:UNKNOWN +@SQ SN:CHROMOSOME_I LN:102 +I 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC PT:Z:27;29;+;STOP;Note=tag1 +II.14978392 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC PT:Z:27;27;+;PRIM;Note=tag2|29;29;+;OLIG;Note=tag3 +III 0 CHROMOSOME_I 2 1 101M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTCAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ###########################"##@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC PT:Z:1;1;+;COMM|101;101;+;COMM +IV 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +V 0 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +* 768 CHROMOSOME_I 2 255 1M * 0 0 * * CT:Z:+;STOP +* 768 CHROMOSOME_I 28 255 3M * 0 0 * * CT:Z:+;COMM;Note=consensus%0Amulti%09line%0Atag%0A!"#$%25^&*()_+<>?:@~{}%7C%0A1234567890-=[]'%3B#,./\ +* 768 CHROMOSOME_I 102 255 1M * 0 0 * * CT:Z:+;STOP
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#unmap.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,6 @@ +I 4 * 0 1 * * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +II 4 * 0 1 * * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +III 4 * 0 1 * * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +IV 4 * 0 1 * * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +V 4 * 0 1 * * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC +VI 4 * 0 1 * * 0 0 ACTAAGCCTAAGCCTAAGCCTAAGCCAATTATCGATTTCTGAAAAAATTATCGAATTTTCTAGAAATTTTGCAAATTTTTTCATAAAATTATCGATTTTA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#unmap1.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,20 @@ +@HD VN:1.0 SO:unsorted +@SQ SN:CHROMOSOME_I LN:15072423 +@SQ SN:CHROMOSOME_II LN:15279345 +@SQ SN:CHROMOSOME_III LN:13783700 +@SQ SN:CHROMOSOME_IV LN:17493793 +@SQ SN:CHROMOSOME_V LN:20924149 +@SQ SN:CHROMOSOME_X LN:17718866 +@SQ SN:CHROMOSOME_MtDNA LN:13794 +@RG ID:UNKNOWN SM:UNKNOWN +@PG ID:bowtie2 PN:bowtie2 VN:2.0.0-beta5 +SRR065390.33808391 4 * 0 0 * * 0 0 GATCGCACTGAAAATCTGGATATAGAACGTGTGCAAATGATTGTCTCTACCGTTCCGTAAAAATTATTGCTAATTAGCAATGATTTTAAGCTAATTAGTT CCCCCCCCCCCCCCCCCCCACCCCCACCCCCCCCCCCCB;CCCAACCCCCCCCCCCCCD=B9BCABCBCB>BBBC@B<<@BA;BCC?B>A<<@(?:4==4 YT:Z:UU +SRR065390.33808433 4 * 0 0 * * 0 0 NCATCTTCTGCAGGCGCGGTCGGCACCGTGTATTCGTTACGTTCCACGCCGATGATATTAGACACCAGCACGGTGTGATGCGCAGTCACCGCACGACCCG !################################################################################################### YT:Z:UU +SRR065390.33808462 4 * 0 0 * * 0 0 NGTTTGAGCGCAATGACTTGACGATGACCGGTGATTACAGTAACCAGCATATTGTGCCGATGAAGCAGGCTGTCGCTCCGCAATTTGAAGAGGGACACGA !################################################################################################### YT:Z:UU +SRR065390.33808468 4 * 0 0 * * 0 0 NGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTTTATTTTACTCTCTGTGGCTTTATCGATTATTTTTTTCTCCTTGGCTTTCCTCTTTATTTTT !))))))''&585555AAAAA6AA############################################################################ YT:Z:UU +SRR065390.33808471 4 * 0 0 * * 0 0 NCGTCTTCTGCGGTTTCTATGATAGAGCAATTCTGTGGCGGATATTAAGATAACGGGTATCTGTTCTTTAATGATGCCGCAAAAAATGGAAAGTTAAGAA !################################################################################################### YT:Z:UU +SRR065390.33808489 4 * 0 0 * * 0 0 NGGAAATTCTGCGGTATCGAGAGATATTTGCCTTTAATTACCCCATAGCCGATTAACATCCCGGCACTATTAATCATTTCAATATTATCAATCACAAAGT !################################################################################################### YT:Z:UU +SRR065390.33808504 4 * 0 0 * * 0 0 NTGGAACACCATGCCCACTTTCGCACGCAGCAGGGCGATATCCTGAGAGTTGGTCAGGATGTTGTCGCCATCAAGCAGAATTTCACCTTCCGCACGCTGC !################################################################################################### YT:Z:UU +SRR065390.33808511 4 * 0 0 * * 0 0 NCAGAAATATATTGAACTTTTGAAACATGTCCCAACTTTTTTTTTTTTTAGAACACGTTGGCTGGTTTTTCAAGTTTTGAATACTTTTTAGGTTTTTTTG !***()(+++AAAAAAAAAA:78:8318::AAAAAAAAAAAA########################################################## YT:Z:UU +SRR065390.33808521 4 * 0 0 * * 0 0 NTGTCAATACATTGTAAGGATTTCCCATTATGTCAATACATAGATCGGAAGAGCGGTTCAGCAGGAATGCCGAGACCGATTTCGTATGTCGTGTTTCTTT !################################################################################################### YT:Z:UU +SRR065390.33808523 4 * 0 0 * * 0 0 NTACTTCTTACAAGATTTTTATCGCTACTTGAAAAAAATTCATCAACATAATCGCCATGACTATCTGCACCGTGAGTATGATAAGCAGCAACTCTATCTG !***+--,')AAAA778577A72AA50888AAAAAAA72A88858AAAA77AAAAAA7AAAAAAAAA8AA############################## YT:Z:UU
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce#unmap2.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,29 @@ +@HD VN:1.0 SO:unsorted +@SQ SN:CHROMOSOME_I LN:15072423 +@SQ SN:CHROMOSOME_II LN:15279345 +@SQ SN:CHROMOSOME_III LN:13783700 +@SQ SN:CHROMOSOME_IV LN:17493793 +@SQ SN:CHROMOSOME_V LN:20924149 +@SQ SN:CHROMOSOME_X LN:17718866 +@SQ SN:CHROMOSOME_MtDNA LN:13794 +@RG ID:UNKNOWN SM:UNKNOWN +@PG ID:bowtie2 PN:bowtie2 VN:2.0.0-beta5 +SRR065390.14978392 16 CHROMOSOME_I 2 1 27M1D73M * 0 0 CCTAGCCCTAACCCTAACCCTAACCCTAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #############################@B?8B?BA@@DDBCDDCBC@CDCDCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:1 XM:i:5 XN:i:0 XO:i:1 AS:i:-18 XS:i:-18 YT:Z:UU +SRR065390.921023 16 CHROMOSOME_I 3 12 100M * 0 0 CTAAGCCTAAATCTAAGCCTAACCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ###############################################???88:;98768700000<>:BBA?BBAB?BBBBBBBB>B>BB::;?:00000 XG:i:0 XM:i:3 XN:i:0 XO:i:0 AS:i:-6 XS:i:-13 YT:Z:UU +SRR065390.1871511 16 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA <?@<@A8>0:BB@>B<=B@???@=8@B>BB@CA@DACDCBBCCCA@CCCCACCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:0 XM:i:0 XN:i:0 XO:i:0 AS:i:0 XS:i:0 YT:Z:UU +SRR065390.3743423 16 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ##################?6@:7<=@3=@ABAAB>BDBBABADABDDDBDDBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:0 XM:i:0 XN:i:0 XO:i:0 AS:i:0 XS:i:0 YT:Z:UU +SRR065390.4251890 16 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ###########@BB=BCBBC?B>B;>B@@ADBBB@DBBBBDCCBBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:0 XM:i:0 XN:i:0 XO:i:0 AS:i:0 XS:i:0 YT:Z:UU +SRR065390.5238868 16 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA @,=@@D8D;?BBB>;?BBB==BB@D;>D>BBB>BBDDB<DABADCACDCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:0 XM:i:0 XN:i:0 XO:i:0 AS:i:0 XS:i:0 YT:Z:UU +SRR065390.6023338 0 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAAGCTAC CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC@CCDDDBCCABB=DABBA?################ XG:i:0 XM:i:3 XN:i:0 XO:i:0 AS:i:-6 XS:i:-6 YT:Z:UU +SRR065390.6815812 16 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ###############?@.@?B;B0B=;<DADB@@BDDBBDDBCBCBD@CCDCCCCCCCDCCCCCCCCACCCCCCCCCCBCCCCCCDCCCCCCCCCCCBCC XG:i:0 XM:i:0 XN:i:0 XO:i:0 AS:i:0 XS:i:0 YT:Z:UU +SRR065390.6905811 16 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA #######################BB@>A<BC>@@BCCB@=BACBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC XG:i:0 XM:i:0 XN:i:0 XO:i:0 AS:i:0 XS:i:0 YT:Z:UU +SRR065390.8289592 16 CHROMOSOME_I 3 1 100M * 0 0 CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA ###############################A?@C9@@BC=AABDD@A@DC@CB=@BA?6@CCAAC@+CCCCCCCCCCCCCCC@CCCCCCCCCCCCCCCC XG:i:0 XM:i:0 XN:i:0 XO:i:0 AS:i:0 XS:i:0 YT:Z:UU +SRR065390.33808391 4 * 0 0 * * 0 0 GATCGCACTGAAAATCTGGATATAGAACGTGTGCAAATGATTGTCTCTACCGTTCCGTAAAAATTATTGCTAATTAGCAATGATTTTAAGCTAATTAGTT CCCCCCCCCCCCCCCCCCCACCCCCACCCCCCCCCCCCB;CCCAACCCCCCCCCCCCCD=B9BCABCBCB>BBBC@B<<@BA;BCC?B>A<<@(?:4==4 YT:Z:UU +SRR065390.33808433 4 * 0 0 * * 0 0 NCATCTTCTGCAGGCGCGGTCGGCACCGTGTATTCGTTACGTTCCACGCCGATGATATTAGACACCAGCACGGTGTGATGCGCAGTCACCGCACGACCCG !################################################################################################### YT:Z:UU +SRR065390.33808462 4 * 0 0 * * 0 0 NGTTTGAGCGCAATGACTTGACGATGACCGGTGATTACAGTAACCAGCATATTGTGCCGATGAAGCAGGCTGTCGCTCCGCAATTTGAAGAGGGACACGA !################################################################################################### YT:Z:UU +SRR065390.33808468 4 * 0 0 * * 0 0 NGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTTTATTTTACTCTCTGTGGCTTTATCGATTATTTTTTTCTCCTTGGCTTTCCTCTTTATTTTT !))))))''&585555AAAAA6AA############################################################################ YT:Z:UU +SRR065390.33808471 4 * 0 0 * * 0 0 NCGTCTTCTGCGGTTTCTATGATAGAGCAATTCTGTGGCGGATATTAAGATAACGGGTATCTGTTCTTTAATGATGCCGCAAAAAATGGAAAGTTAAGAA !################################################################################################### YT:Z:UU +SRR065390.33808489 4 * 0 0 * * 0 0 NGGAAATTCTGCGGTATCGAGAGATATTTGCCTTTAATTACCCCATAGCCGATTAACATCCCGGCACTATTAATCATTTCAATATTATCAATCACAAAGT !################################################################################################### YT:Z:UU +SRR065390.33808504 4 * 0 0 * * 0 0 NTGGAACACCATGCCCACTTTCGCACGCAGCAGGGCGATATCCTGAGAGTTGGTCAGGATGTTGTCGCCATCAAGCAGAATTTCACCTTCCGCACGCTGC !################################################################################################### YT:Z:UU +SRR065390.33808511 4 * 0 0 * * 0 0 NCAGAAATATATTGAACTTTTGAAACATGTCCCAACTTTTTTTTTTTTTAGAACACGTTGGCTGGTTTTTCAAGTTTTGAATACTTTTTAGGTTTTTTTG !***()(+++AAAAAAAAAA:78:8318::AAAAAAAAAAAA########################################################## YT:Z:UU +SRR065390.33808521 4 * 0 0 * * 0 0 NTGTCAATACATTGTAAGGATTTCCCATTATGTCAATACATAGATCGGAAGAGCGGTTCAGCAGGAATGCCGAGACCGATTTCGTATGTCGTGTTTCTTT !################################################################################################### YT:Z:UU
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce.fa Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,20803 @@ +>CHROMOSOME_I +GCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGC +CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCT +AAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA +GCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGC +CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCT +AAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA +GCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGC +CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCT +AAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAAAAATTGAGATAAGAAAA +CATTTTACTTTTTCAAAATTGTTTTCATGCTAAATTCAAAACGTTTTTTT +TTTAGTGAAGCTTCTAGATATTTGGCGGGTACCTCTAATTTTGCCTGCCT +GCCAACCTATATGCTCCTGTGTTTAGGCCTAATACTAAGCCTAAGCCTAA +GCCTAATACTAAGCCTAAGCCTAAGACTAAGCCTAATACTAAGCCTAAGC +CTAAGACTAAGCCTAAGACTAAGCCTAAGACTAAGCCTAATACTAAGCCT +AAGCCTAAGACTAAGCCTAAGCCTAATACTAAGCCTAAGCCTAAGACTAA +GCCTAATACTAAGCCTAAGCCTAAGACTAAGCCTAAGACTAAGCCTAAGA +CTAAGCCTAATACTAAGCCTAAGCCTAAGACTAAGCCTAAGCCTAAAAGA +ATATGGTAGCTACAGAAACGGTAGTACACTCTTCTGAAAATACAAAAAAT +TTGCAATTTTTATAGCTAGGGCACTTTTTGTCTGCCCAAATATAGGCAAC +CAAAAATAATTGCCAAGTTTTTAATGATTTGTTGCATATTGAAAAAAACA +TTTTTCGGGTTTTTTGAAATGAATATCGTAGCTACAGAAACGGTTGTGCA +CTCATCTGAAAGTTTGTTTTTCTTGTTTTCTTGCACTTTGTGCAGAATTC +TTGATTCTTGATTCTTGCAGAAATTTGCAAGAAAATTCGCAAGAAATTTG +TATTAAAAACTGTTCAAAATTTTTGGAAATTAGTTTAAAAATCTCACATT +TTTTTTAGAAAAATTATTTTTAAGAATTTTTCATTTTAGGAATATTGTTA +TTTCAGAAAATAGCTAAATGTGATTTCTGTAATTTTGCCTGCCAAATTCG +TGAAATGCAATAAAAATCTAATATCCCTCATCAGTGCGATTTCCGAATCA +GTATATTTTTACGTAATAGCTTCTTTGACATCAATAAGTATTTGCCTATA +TGACTTTAGACTTGAAATTGGCTATTAATGCCAATTTCATGATATCTAGC +CACTTTAGTATAATTGTTTTTAGTTTTTGGCAAAACTATTGTCTAAACAG +ATATTCGTGTTTTCAAGAAATTTTTCATGGTTTTTCTTGGTCTTTTCTTG +GTATTTTTTTGACAAAAATTTTTGTTTCTTGATTCTTGCAAAAATTTTTC +CGTTTGACGGCCTTGATGTGCACTACCTTCGCTTAAATACTACATTTTCT +GAAAATGTTATAATAGTGTTCATTGTTTCATACAAATACTTATTTAATAG +TATTTCTGGTTATATAATTTGTATAAAAAGTGGTTGACATAACAAGGCTG +ACGAAACTTTGTGATGGCTGAAAATATTTTCCTAGCTTTATTGATTTTTA +TTTATACGTGTTTGAATAACTTGGCCAAATCGCCGAGAAGGAATAGAATA +CTGGACGACATTGTACATATTTTCCAAAAAATCAGAAAGTAGATGACGGG +ACCAATTCTTTCTGTCAGGTTTTACAACCGCCCAGTGCGTCTACGTCACA +TGTTGTATAAATGGTTGTAAACAATATGCGGAAACAATCAAATGCATTCC +CATAAGGCATAATATAGAGGCTACAGGCAATGAGTATCGCTCTTTGCTTT +GTTTAAAGGGGGAGTAGAGTTTGTGGGGAAATATATGTTTCTGACTCTAA +TTTTGCCCCTGATACCGAATATCGATGTGAAAAAATTTAAAAAAATTTCC +CTGATTTTATATTAATTTTTAAAATCCGAAAATCCATTGGATGCCTATAT +GTGAGTTTTTAAACGCAAAATTTTCCCGGCAGAGACGCCCCGCCCACGAA +ACCGTGCCGCACGTGTGGGTTTACGAGCTGAATATTTTCCTTCTATTTTT +ATTTGATTTTATACCGATTTTCGTCGATTTTTCTCATTTTTTCTCTTTTT +TTTGGTGTTTTTTATTGAAAATTTTGTGATTTTCGTAAATTTATTCCTAT +TTATTAATAAAAACAAAAACAATTCCATTAAATATCCCATTTTCAGCGCA +AAATCGACTGGAGACTAGGAAAATCGTCTGGAGATAGAACGGATCAACAA +GATTATTATTATATCATTAATAATATTTATCAATTTTCTTCTGAGAGTCT +CATTGAGACTCTTATTTACGCCAAGAAATAAATTTAACATTAAAATTGTT +CATTTTTGAAAAAAAAATAATTAAAAAAACACATTTTTTGGAAAAAAAAA +TAAATAAAAAAAATTGTCCTCGAGGATCCTCCGGAGCGCGTCGAATCAAT +GTTTCCGGAACTCTGAAAATTAAATGTTTGTATGATTGTAGAACCCTTTC +GCTATTGAGATTTGATAACTTTTAAGTAATAAAATTTTCGCAGTAAGACA +TTAAAACATTTCACAATTAAGCTGGTTCTGAACTGTGTGAAGTATATTGA +AAAAAACTAACTGATACAAAAATATAATTTTATGATAGTTTTCTGGATGT +CCCAATATAAACGATGTCAATTCTGCGACATGCTACAGTCATCCACGAAA +GTAACCCGAATACCGACAAAAGAAGAGGAACGCCAACTTTGGATAGACGC +TCTAGGGGCTGATTTTGGTCGGAAAATAGTCGGGAAAAAATAGAGGACAT +TACAGATGAGGATGAGGATGAAGATAGAAATTTGCCGACAACTTCGTCAT +GCCGCTGATTTTTTTGATGTTCTACGCTTAAATTTTCAGCGAACGAACTA +TTTTTTATATTTTGATTGTTTTTAAATAATATTTGCCATAAGAAATTCTC +ACTTTTCCAGGAAACGTCGTTTCGCCGCGATTTTCCTCGTCTCCAGTCGA +TTTTGCGCTGAAAATGGGATATTTAATGGAATTGTTTTTGTTTTTATTAA +TAAATAGGAATAAATTTACGAAAATCACAAAATTTTCAATAAAAAACACC +AAAAAAAAAGAGAAAAAATGAGAAAAATCGACGAAAATCGGTATAAAATC +AAATAAAAATAGAAGGAAAATATTCAGCTCGTAAACCCGCAAGTGCGGCA +CGGTTTCGTGGGCGGGGCGTCTCTGGCGGGAAAATTTTGCGTTTGAAAAC +TCACATATAGGCATCCAATGGATTTTCGGATTTTCAAAATTAATATAAAA +TCAGGGAAATTTTTTTAAATTTTGTCACATCGATATTCGGTATCAGGGGC +AAAATTAGAGTCAGAAACATATATTTCCCCACAAACTCTACTCCCCCTTT +AACAACCACCCGAGGATATATTCGACAAACGATCTATCTACTAGGAATAA +CTCGATTATTGACATATTATAGACTTCTTTTAGTATTTGTAAAATAGAGG +ATCAGACCCAAAATTCAGCCCGCGAAGGCATGACGTCAGCGCGAGGCAGT +AGTTTCCAGAAGAACTCTGTCGTCTACCTTAATGCCTCAAATGCGAACCC +GCTTCGGCCATCCTTCTCGCTCAGAGAATGGATTAGAGTTCTCATCAACT +CCTCTGTCTAATTTTCAACTGCGGCGGTTGGCGACCGGTATTACCGCGGC +GACCGACACCTCCCGGGTTCCGTCGATCGCTGTCTGTTGTGTGCGCCGCG +ACTCCGCCCACCGGTGGTAACTTTTTGTGGGGGAATCTTTGTTTTTGGTC +ATTTTTCAGCGCTTTTCAGCGATTATTGACCAATTTTGAATAAAATTTTC +AACAGAATATCATCTAAAATATTGCTTAACATTTATTTAACAGAAATAAC +GTGAGCACGCATGTAAAACATGAAATTTTCGGGAAAATTGCAATTAAACG +AATAAAAATCGATATTTAAATCAATTATTGGTGAATCCGGTGTGTTGAGG +CTTCAATGCATACATTTTTACTGGATAAATCTCCTTTGGGAATCCGGTTT +GCAGTGCTTTCGAGACCATGTCCAGTTGAGAATCGGCGAACGCTTTAAGA +AGCTCGGGCTGAATAATGAATTGTTTTAAAAAATGTTTAGTAAAAAATTG +TTTTCGTGCAAATTGTCTTCGATATTATCCAAACGTGACGTTTTGCGATT +TTCGCGCTAAAATTACAGTAAGTGGGGTCTCGACACGACAATTTTTGTGA +AATACAAACGGGCGTGTGTCTTTAAGAAGTACTGTAGTTTAAAAACTTCA +TTTCTGTGGAATTTTCATATATTTTTCATAGTTTTTCTCTTTAAATAAAT +CACTTTTCAACAAAAAACTATGAGACAATAGTTTGAAATTACAGTATTCT +TTAAAGGTGCACGCCTGCTCGAATTTCGCAAAAACGTGTCGTGTCGAGAC +CCCAATTACAGTATTTTTGACCCGAATATCGCGAAATTTCGAGTCTGGGT +GAAAACATTGAAATTTTTGGCAAAATAAAAGAAATATGTCCTTTTTCAGA +ATATATTTTCTAAATTTCGAGACGAAACAACAATTTTAAATGAATTTTAA +TTTTAAATATTAAATATTTCGGAATTTGGCGTTTTTTATGCATGTCGATT +CACTAACGATTTTGTACTACACGTGGGCAAGTTTATACAGTTTTTGGCTA +AAATTTGTGAATTTGAACCGTTTTTCGGCGAATATTTGAAAAATTGGCAA +AACTGGTTCAAAAACAAAAATTTTTTAAACTGTACAAACTGTCCAAAAAT +TCGTCGTAAATCGACACACCCTTCTCATTTTTTCAAAATTTTAATTGTTT +TCGAATGTTTTTTTTGCAGAATAATTTGTAAAATGAGCCTTTTGTGAATT +TTTTTTAATTTCAAAGTTTTTATTATTTTTTCTCAAACCAGCACCTCTGT +TCTCGTCCAACTATGATCATCATCGTCGAATAACCGTTTCTCGTGATTTG +TCACATTATCCTTGAGCACAATACATCCACCAGGTTTCAGTCCTTTCTGA +AAATGAAAATTAATTTTAAAAAAATTGAATTATTTTAAATGAAACAGTTT +TCAGAGATTTCTCAACTTTTGAGTCCACCACCAGGCCTGCACGTTTTTCG +GGTTTTATCTTTTAAAAAACTGAAAAATCGAAAAATTTCAATTTCTGTTT +TGTGGTCAAAATTGTAATTACAGGTAAGCAAATAGTTTAATTTTAAAATT +GAAAATTAGGGAAATGACCGGACATAAGTTTAAAAACCCGATTTTTTCAA +TAAAAAGGAAAATTGAAAATTTAATAAAACAGGTTGTAAATCAAGGAGAT +CGTATTGATTGAAAAAAAATCCGAATGTTCCGGATTTTTCAGTGGTTTTT +TTTGAAAGAAAATCGAAAAAGTAAATGTTTTTAATTTTTAAATTTAAATT +TTTAATCGGAAAAAATGTACGAAATTGACTTTTTAATGTGAAAAATTGTT +GTTTTAAAAAAAAATTTTAACCGATACAGATTTTCTAGACTCAGTTTTTT +CGGTTGAATATTGTTTTTTACTATTTTTTCATTACAGAAAGAATCCAATT +TTATTTCGCTTAAAAAATAACCGGAGCATCGAAAATATTTTTTTTTCTGT +TTTACTCAAAGCATTTCAATTACCTAGAATTTTGTTTAAAAACTACATGC +TTTATTTATGAACGTAATAAATAAGACCCCCTCTTATTTATAAACTTTCA +ACATATTTTCAGTTTTCAGTGCTATCTAGTGCTTACCGCACATCTTTTAA +AGAAATCAACCAAATCCTCATCAACCAAATGCCCTGAAACCCATTGAATC +CATATCAAATCATAACGTCGTTCGGGCGGTGCAAACGTCTGCAGTCCTTC +GACGAATTTATCTCCAATTCGTGGATGTTTTCCAATATATTGATCACTTT +TCGTGATCAACTCCTCGACGACGTCTTCCATATCAACTTTCGAGAAGAAT +GGCATTAAGAGATGCTTTGTAACACGTCCGATACCCGCTCCGCAGTCCAG +TGCATAGTCAAAGTAGCCGAATAGATTCTGGAAAATATTTATAAAATTCA +AAGTTGGCCCAGGGGTGACCGGCAATTTCAAGCAAATCGGCAAATTGTCA +ATTTTCTGAATTTGCCGAAAATTTGACAAAAACGACAATTTGCCGGTTCG +CCGAATTTACCTTTTTTAAATTTAATTTTCAATTCAGGCAAACTGACGAT +TTTCCGTTTGCCGGATATCAATTTGCAGGAATTTCTCAAAGGAATTTTTA +TTAAGACGGAAACACAGTGCTTTTTTGAATTTTTTTTCCCGTTTTCTTCA +GATATTTTTATAGAATTTACTGACTTTTCAGAATAGATGTAGGACAATTT +TGTTGTTTTAAAAATTGAAATTCTGAAATTTCCAACAAAAAAACATGTGC +AAACCCACAAGTTGGCAAAAATATTTTGCATTTGCCGTTTTTCCCGTTTG +CCGAAAAGTCTAATTTCGGTAATTGGGCCATTTTTCGAAATTTTGAGCCA +CATAAAAAACTTTGAACCATTTTTGAGAAGTATTATTACGACATTCGTTT +ATTTGAGCACAATTTGGGCCTATACTTTCAAAATCGGGGTTTGAAAACCC +CTATATGTTCGACCGAATGTTAATCTCATAAAAATTTGATGAAAATAAAA +TTTTCTACGGCTCATAAACGTATAGCCCCCGTCAGTCTCAAAATTTATAC +GATAGACACTTTTTGGCGTTTATCGCCTATATTCCGTCAAAAACCATTAT +TCATCATTCTTTCAATGTTGTTTTTTTTAAGGCTAAAAAACTTTCATGCA +AATTTGTTAGCCGTGTCGTGGTTTATACGAAAATTTCAGAATTTATAAAA +TAAAGGAAAACGAAAATGTTTCTATATACCCTATTTATGTTCTCTGATTC +CGAATACCAATGTGAAAAATTCAAAAAAAATTCCCTGATTTTATATAAAT +TTTTGTAAGCGACAAAAATTGTCGTTTGAATTTCACACTTGGTTACAAAA +ATTTATGAAAATGAGGAAAATTTGTTTTAATTTTTTCACATTGATATTCG +GAATCAGGAAAATAAATAGGGTCTATAGAAAAATTCCGAACCTTCACTCC +TTCTCTGAGTATAATAAATTTAAAATAAATACAGAAAATTTCAGTTCAGA +CCTCATTAAATTTGGGTATATTTCTAGGATCCGAGTTTTTACACCAGATT +TACAAACTTTTAGCCTTTCACCGCCTTTTTATGCGCATTTCCCATCAGTC +AACTCCAAAAAAATCGCAACTTTTGCCTCATATTTCAAGAATATTCCCCT +TTCTCTCCCCATTGAAAGTCATTTTCGAAACAAGCGGAAGATTCGTCATA +TGTGGTAATGTGTGGCGTGCGTTGGCAAACAACAAGAAAGAATCATTCTC +TGAAAACAAAAAGCGTTTTGGGTGCCAAAGTAATATTGAAAATCTGCCGT +GTTTTCTCATTTTCCATCAAAAGAAAATGAGAAAAAAGTTTCGGCGTTTT +ATTTGATTTCCGGGAAAGAAGACTCGGAAAAAGATTTAATTGAATTTTTC +ATAGCAAACCTATATTGCAACAACTTTCTAAAAGGTCAGAAATTGCCGCG +TAGCCTAGAAAATTGGAAAACTCTTCCAGCTGGTATTATTTCAGACATGG +TGCATCGAAAATTCGAAAATTACAGAAATTAACATTTTGGAGCATCTGCC +AGAAAATTGAGATTACAGTACCCCACTTCTGCCGAGAAATTCGAGGTGGA +AGAGGTCTTACAAAATTTTCGGTCACGTGAAAATGGGAAGCGTTCAGGCT +CCACACGACGGAATTCACCTAGTTTTCAGGTGAGAAGATATCGTACGAGG +AGAATTGACCTCCAAATCCTGATCGTGACTACAGGTCGTCGTTCGGAGCT +GTGGAAGAGTTTTGAAAATCTTCGACCATGAGAGAAATAGACAGGACGAC +CAAACATTTTCAGTGGAAGAGCTTTTCCTAGGCCATCAGGATGCTATTTC +GACAGAGCTGAGTTATCCTCAAGTCGTTACGAGGTGTGGAAAAGTTTTCC +AAAATCCCCGACCAGGTAGAAAATGAGCACACCGATTAAGTTTCTCCAGT +GGTAGAGTTTTTTCTAGGCCATCATTATGCTATCTAGAAAAAAGCTTCGG +CCATGGGGTTTTTAGGCCGTCTATTTATTTCTCATAACTTTCTCAGAAAT +TCGTCTATTTCTCAGAACCCCCCAATGATAAGTTTTTTGCAAAAAAAGTT +CTGCTTTGCTCATCAGCCGTAATCAGGTGACCTCATTAGGCCTACCCAAA +CACAGATTTGTCATTATTTTTCAGACAAAAAACACGAAAAAAATCTTCAC +GCATGGGGTGATAACCTGATTTTAAATCTTACTGTGCCGGCTGGCGCGGC +GAGCTTCGATCACTGAGCCGAAAGATTATGAAAACTATGGGAATGACGGC +GTAGCCTAGAAATCGTCCAGGCAGAGATTCTGTCTAATTTTCGAGCATAT +ATCTCCCAGTTTTGTTATTAATTTAAGTAAACTCAAACCTAGAAACAAGT +AAAACGGGAGGGGGGGGGGGAATATCAGAAAATTAAATCTTGCGACACTT +TTCCATTGATACTTTCAAGGTAATGCCCAGAGGTGTGCGGCAAATTTTGA +AACTTGCGCATGCCGCCTTTTTTTTTTTCTAGAAAACAGTCAGAATTTTT +TGTCGAATTTGTTGAAAATTCGCTAATATACTGTGAGTTTAGAAAAAATA +ACGAAAAAACTCGGAAAAGGAGGAAGAGATCTGAAATATGTAGATTTTTT +TAGAAAAGACCAGAAATTACTGAAAAATTGGCATTTTTCGTCGAAACCCC +AATATACTAAATTATTCGGATTTTTAGAAAATTTTCAAATTCACCATACA +GTGCATTTTTTCCTACTTCTACGACTTTAAAGGGGGGAGCATTTATGCGG +AAGGGTCTTGCCGCGCATTTAGTCATCATTTTTAGCAGTTTCTGTGTAAA +ATTCGCGTAGATCACATGAAGATCACAAAATATTTATCCCATATTTCGTA +TTTCTGTTGCTTTTTCACAAATTAATTGTGATCTACGCGTGATCTCCGCG +AATTTTGAGCAGACTTTGTTAAAAATGATGACTATGTGCACGGCAAGACC +CTTCCGCATAAATGCGCCCCCCTTTAAAGTCGTAGAAGTGGAAAAAAAAT +GCACTGTAGCAAAAAATCGAACATTTCTGTTCGATTTTTGAATTTCTCGA +AATTTTTTAAAATAATTTTTAAAATAACATTTTTATTTTATTTCGAAAAC +TACCGATTTTAGAAAAATTCTAAAATTTCGATTTTTTTTGTTGATTTTTC +GATTTTTAAAATAAAATTTCATAATTTTTTAAACCGATCTTTCTTGCTTT +TCCTGAAAAATCGATGATTTCTATACCTTTTTCTTCAGTCCTTCAATAAA +TCGTTTCGACGCCGATATGTCGGGCGCGTGAAGCGCTTCGAATCCGCCGA +GCATTCCGTTGACGTCCTGGCTCGCGCGGCTCCAGTATTCCTCCGCCTGA +AAGAGAATAGTTGAAAACATTGTTTTGAGACTTAAAAATTTTTTTTTTAG +TTTTTTTCAAAAATTCTTACATGTTATAGAGTTTTTTTTTCAAATTTTCA +GCTTTTTTCAGAAAAACTTAGTATTTTCGATAATTTTAAATAAAAAAGTT +TTTTTTCAAAAAATGTTTCGGTTTTTTTTTTAATTTTTGGTCTAAAATTC +TCCGCAAAAGATTTGCGTGCTGGCCGAACTTTTTGATTTTGTACCTTTTC +ATAAACATCTTCACCATTGTGAATTCTAGAAGATGATGAAGAGCTCATTT +TTGATGTTGTGACAGCTGCTCCGAGCAATCTGGAGACTTTTGTGACGAAA +AGACGAGAGGTCACGGATATGATGATGATACTGGAAATGAGATATTTATA +TTTACTAGTTCATCGGGAAAATTATTACGAGAAAGATAAACAGACATGTG +CGTTTTTTTAATGGAAGAGAAACACAAGAAAAATCTGGAAAACTAGGCCA +CGGCTATCAGTGTCGATTTACGGCATACGGTCTCGACACGACTATTTTTG +TTAAATGTGAAGGTATGCACCTTTAAAGAGTACTGTAGTTTGTAACTCTC +ATTGCTGCAACATATTTGACGCTCAGCGAAAACTACAGCAATTCTTCAAA +AGACTACTGTAGCCTTTGTGTTGACTTACGGGCTCGATTCTCGAAACGAA +TTTCTGCTCGAATTGTGACAGCCATATTCAATTTGGTATAGTCTTTTCGT +ATTTTTTGCCATTTTTCTGTTTTCTTCTAATATTTAATCTATTATTAAAT +TATGTCCGTAACTCCCTCCAAAATTAGAACTGCGACCGAACAGAGATTCG +TTCCGCCCCATATTCCGGCCAATCAGATCGAGTAGGCGGAGTTCGAAGTC +GCTGATTGGTTTGAAAAGTCGCGGAAATTTGCAAGTTTTAAGGTAGCGAA +AACTGATGACTATTGTAGCGCGCTTGTGTCGATTTACGGAATCTCGATTT +TCAGGAATGAATTTTTAATTACATTTTTTCGCTCAATTAATATTCTAAAT +AAATAAATAAATGATTTGAATTAATTTAATTTCATTCGAGCCCGTAGATC +GACACATGTGCTACAGTAATCATTAGTTTTCGCTACGAGATATTTTGCGC +GTAAAATATTTTCCCGTAATAACTCTACTCCGACAAACATTACGACCTCC +ATGGAGGCCTCCAGGTATAGGTGAGACTCTTGTATTTCCAATTCAGAGAC +AATGCGTCACTGGAAGAGAAAACGAAGCGGAAAAAAAAACACGGAAACCC +AAAAATAGTGTTTGCCCCGCTCTATTCTTCTCCAATAATTTCTGTGTCTA +ATTTTGAAAGACTCCACCTGTGTATGCCTTCTCGACATAAACCCCCCCCC +CCCCCCCTATCTTACATGGTACTGATAACACTTTCAGTCTTTCACACTTT +TGGCGCGCAACGCCGCTCTTTTTTCGCGGCGAGCTGATGACGTCATCAAT +TTTTCATCGCTTTTGATTATCTTCAATGTTCTAGAAGGGCACATAGGTCA +TCCTTATTTTTTCCTTCTCTTTCTCGTGACGGCCCTTGTTGCGCATGCCC +GCCCCCTAGAGCAGGGCGTGGCCTGAACGGCGGCTCCGAGAGCTACTCAT +TCTTGCCGCGTCACCCTCCAGCGCCACCCAAACTTCTTCGGTTCTAGAGA +TCGAGAAGAACGTATGATTTTTTAAAATTATAATTGTTTCTTTCGAAAAA +AAAAATTTCATTTACAGTAAGCCAAACATACACAATCAACATGAAACTCG +TAATTCTGCTATCTTTTGTTGCGACAGTTGCGGTTTTTGGTGAGTTTATG +CTTTAGATAATACTTTTCCGCCAAAAATACAGTTGCCGGTCTCGGTATGG +CAATATTTTTGTTAAATTCGAAAAGCAGTGAGTAATGTAGTTTCGAATTT +TCGTTTCTGCTTAATTTTCATCAATTCATCGTTTTTCTCACGACTTCTTC +TTTATGAAAAATCAATGAAAATTCTGACTAGGTCAGCTTAGGGGTGAGGT +ACCTAGAGACGCCACATATGCCAAACGGAAGCTGAGATCATTGGCTACAA +GAATATGCTTTCAAATTCTGCAACGGACCTCTGGGAGTCTGGAAATTCTT +GTCTGAAATTATGCTTTTGAATGCTCGAAAGTGGTAAGAATTTAGAATTT +ATTACAGAAAAACGTTTAATTAATAAAATTAGTTTTATACTTGAAACAAG +TACTGTATGCACTGTATCAAAACACATTTTCATCTTTTCTAGGTATTCAA +CTTCACGTTTTTCTGTAATAAATTCTAAATTCTTACCACTTTCGAGCATT +CAAAAGCATAATTTCAGACAAGAATTTCCAGACTCCCAGAGGTCCGTTGC +AGAATTTGAAAGCATATTCTTGTAGCCAATGATCTCAGCTTCCGTTTGGC +ATATGTGGCGTCTCTAGGTACCTCACCCCTAAGCTGACCATTCCCTAGTG +AGCAAACAAAATTTTGAAATTACAGTACTATTTAAAGGCACATTGATTTT +TTGGGTCAAGCAAAAATTTGTCGTGTCGAGACCGGCTACGGTATTTTCGC +GAAAAATCGCAAAATCTTGCGGCTGGGATATACTTGTGCGAAATACTTTT +TGCATTAATTTTGAGCAAAATTATTTTTTTTAGACTTTTTGAAATCCAAA +TTTTTTGGATTGCGAAAAAAACCTGTGTCCGGTTGTTTCATTAGGCCAAC +AAAGTTCCTGGAACACTGATGAAAACCATGATAGAGGCGGAGCATAATAT +CGATTTTTCGTACTTTCCTGTATTTCTTCTTCTATATGGCCGAGTAGAAC +AGGATTAGGGGTAAAGTCAAAATTTTTCTCATATGGATATCATATGGATA +TCAAAATTTTTCTCATATGGATATGGAGAAAATTTTTCTCATATGGACTT +TGAAAGTTGAATCACTTGACATCTGGGAAATTAGTATTCCAGGCGTAAGT +CGGATCTGTTAGAAACGGAATACTTATAGGCTTCGTGAATTAGGTAGACT +TTCAATTAATCTGATCCATGGGAGTCAGACGCGGTTTCCAGGCCTGACGC +CTGCCTCCAACTTGCCCGCCTCACGCCGGTCTCTCGCCTCATTTCTGCAC +TGTGACGAGACAGACGAAGGTCGCCTTCTGGCGCCCGCATGGAAATCCTA +CGAATATGTCAGCTTCTGATGGGACTCCGTAAATCGACACACAGGGGTAC +CTCAGACATTTCCCTCCCCCTTACAAATTGTTAGGACAAGGAGGGGGAAT +TCATCTCCACTCGAGACACACATATGTTGTCGTCAGTGAAGTGTAAAGAT +CTAAACGATTGCGTGTATGAAAAAGCACTCTATGATCACCTTTTTCATCT +TCCTACACCCTTTTTAGGTGTGGTGCCCATCGAGCACTCACGCCAGGCAG +GGAGAGCACCGGTCCCTGACTAATGGGATTCGAATGTTTTAGACCGGAAA +TAGGAGCGATGAAAGAGCATAGAAATGATCATTTGGAAATCACGTTTAAT +TAGGTTACGGCGAAAATTTGCAAAAAAGAGCAGGAAACTTGGCTCAAATC +CTTCGAAATATAACAACTAGGACTTCCATGTAGGCGTTAAAGCGCCCTGT +CTCTCACCCCAATCCGTACCTTAAGCTGAAACAAACGTGAACTTTTTTCA +TTTCTTAAAGGAGTATCGTCAATGGGAAAATTGTTTTAAAATGTAGTATT +TGTACTTCAACTTCCAATTATTGCAAAAGAAAAACGGAAAAAATCCGTTA +ACATTCAGCATTTTAAGTCGAAGAAATCTTTAAAATTTAACTAGAGAAAT +CCTAGGCCACGACGCTCATTCGAATTTTAATTTGTTTTGATATTGTATTT +TGAAAAAAAAACTTAATACAATTCCTTCTTCCCAGTTTTCTATAACTTTT +TGAGAAAAAAACGAATTAAATTCCGAAAAAACTACATTTAAATCAATATT +TTGTTTACGAATATGGCCTAGAAATCGCGTGGTGGCCTAGGATTCATTTG +CGCGCGAAATTCAAATTCCGTCACTTTCGTCGATTTCAACGGCTAAATGC +TGAATGTCAACGGATTTTTCCCGTTTTTCTTTTGCAATAATTAGAAGTTT +GAGTACAAATACTACATTTTAAAACAATTTTATTTTTGGTATTTTGACGA +AAAATTGATTTATTGGTTTTTTTGGTTGTTTGGGACCAAAAAATCCAAAA +AAAATGTTTGGCGTGTCTAGTTTCGACTCGAGACTATTCTGTATTAAAAA +TACATTAAAACATGTATTTTAACACAGTTGTGACGTCATAAATGTATTTT +GATACATTTTGCAACATTACTTAAATAACCCCATTAAAAATTAACCTAAG +CATCAAAAATTTTTTGGTTTTTTTGGTTTTTCGAAAATTTCAATTTTTTT +TGTTTTTTGGTTTTTTTTGGTTTTTCAAAAACTTCAATTTTTTGTTTTTT +GGTCCAACATTTTTTTTTGGTCTCAGCTCTGCTGCCTACCCTAGAAGAAC +TAATAGCGCTTCAAAAACTGATGAAAACGTTCAAATTTGTCGAAATATTA +CGAAAATTTGAAAAGTTGGCTCAAATCTAGATTGAATCGGCCGATTTTCC +ACAAGTTTCCAAGTTTCCACAAGTCGCCACATATCCCGAGAAAAATCGAT +TCAAATTGTTTGAAAATTGGAATACTGCGAATTTTGAACCAAATTTCCCT +GGCTTCTCTGTTGAAATACTTGAAAATACCGCGAAGCAAACAAAAAATCT +AATTATTACGTGAACACAAAATTCTGAAAATGCGTATATATTGCGCAACA +TATTTGACGCGCAAAATATCTCGTAGCGAAAACTACATTAATTCTTTAAA +TGACACGCTGTATGTGGTGATTTACGGGCTCAAAAAATTATTTTCGAAAA +TCAAGCCCGTAAATCCACACGTAGTAATTATATAAAGAATTACTGTAGTT +TTCGCTACGAGATATTTTGCGCGCCAAGTATGTTGCGCAATACGCAACCC +CATATGTTGATATATACTGATGTGAGGATAAAAAACAACACAACTTTCAG +CGGCTCCATCGGCTCCGGCAGGTCTCGAGGAGAAGCTGCGTGCTCTTCAG +GAGCAACTGTACAGTCTGGAGAAAGAGAACGGAGTTGATGTGAAGCAAAA +GGAGCAACCAGCAGCAGCCGACACATTCCTTGGATTTGTTCCACAGAAGA +GAATGGTCGCGTGGCAGCCGATGAAGCGGTCGATGATCAATGAGGATTCT +AGAGCTCCATGTAAGTTAGTGGTGGTGGCCGGAAAAGAGAAAACTCGGCC +AAGCTGCTCGGAGTTTTTGAATTTTTGATAATCCGAAATAAAAATTGATT +GCTCGAAAAGGAACAATCTTTTGGAAAAAAACGAATTTTGTCATTTTTTT +CAGCAAAAATTGATTTTCGAATTTTTCCAATAAAAAATCGATAATTTCTC +CCCGTGCAGTGGAAAACAAACAATATTTTTTTGTTGATCGTTCTCTTCCA +AACCCGGAATAGGTACACACATTCCTGCGTCATCCCATTCTCTTATCACA +CTTTTTTTTCGAAAATAAAAGTGTAGAGACGGAAAAGTGAGAAAGGAGTC +AATTTTATGCGAAATTTTGCATGATAATACACTCAAATTAAAAAAACTGC +GTGGCGTGCACTGCAGAAAACCTCATATTTAGGCCCCGCCTTTTTCTCGT +CCACTCACGGAGAAAAGGCAAAAATTTGGGGACCAACCAATATCAGGCCG +CCGACATCCTACGGGTTCCGCGCGCCGCTATGTTTAACTCGCTGTGGGTG +TGGCGAGCTGTCTCCGCCCGCTGCGAGTTAAACATAGCGGCGCGCGGAAC +CCGTAGGAAGTCGGCGGCCTGATATTGTTGGTCCCCAAATTTTTTCCTTT +TCTCCGTGAGTGGACGAGAAAAAGGCGGGGCCTAATTATGAGGTTTTCTG +CAGTACACGCCACGCAGTTTTTTTATTTTGAGTGTATAGGTCTCGATTCT +CGAAAGTATGACAGTTATTTAAATGATGAACTCGTGATGACTGTTAAATT +TTTGGAAATTTCGGGGGAATTATATCGATTTTTCGATAAATTTACAGGAA +AAAAGTCCAAAATCTAGGTATTCCATGGTAGGCAGGCGCGATTTCTTGAC +GCCTGCCTGGAATCTGTCCGCCTCACACCAAAAAATGTCAATCATTTTGC +TGAAAACCAAATTAAGAAATGAAAAAGTGCACTTAGAGATGATGACGGAG +GTCGCCTTAAGGTCAGACAGGTTAAAAAACCGATTTTAGTTGAGTTTTCC +CGAAATTTTCTGAACAACCGAATTAGAAATATGCTGCTTGTCATTTTTGA +GTAAAAATTAACGAAAACTTCGACCAAAACCACGAAAAAAATGAAGAAAA +TAAAGATTTTTCGAGAAAATAACAACAAAATCCAGCAAATAGTGAAAAAT +AGTTTTATCCGAGAAAAAGTAGTTTAGACGCTATGAACTCTCGAAAATCA +GATTTTTTCAATCTAAAAGCCATAAAATTATCGATTTTTTAAAAATTCTC +ACTGAAAACCGGCGAATTTCAGTGCTCCACGCAATCGAAGCCCGCTTGGC +CGAAGTGTTGAGAGCCGGAGAACGCCTCGGAGTCAACCCGGAGGAAGTTT +TGGCGGATCTTCGTGCTCGTAATCAATTCCAATAAATATTCTTTGCCCTA +AATACTTTAAATTATCCATCTGACAACTAAAATTTCGGTTCTTCTTGGCT +TCTTCTATTTGTGAAATGGTTTATTTTCCCCCGAACTCTCAAAAGGTTTA +AATATTGTTCGATTACCCCTTTTTATCAATTATTTTCTTCAATTTCTTAT +TTATCATTATTTTTCTAAACGAAGACGGATGTGATTTTAAATTATGTTAA +TGGACTATTTTACAAACTGAATAAATTCAGCATGTTGGCAGGTTTTTTCA +GTAGTTTTTGAGTGAAAATAGAGGTAAAAAGACAGAAAATCAATAAAAAA +TGAAAACAAAACTATGAAAAATGGTTGAAAATCGAGCAAAAATCGTTCAA +AAAAAAATAAATTCAAAAAATAATTGCGTCGAGAAACGCGTCAGTAGCCG +CTCTCTGCGTCTCTCACCCTTCAGCACGCGGAGAGAGCCACGAGAAATGC +GCAAAGGCTAAATTCGGCGCGGAAAATCATTTTTCAAAATAAATTCGACG +AGAAAATCAATACTTAAGTAATTATCGATTTTCAGCTCGTTCAAAAAATT +TTCAGAAACGTTTTAGTCGTTTAAAGGTTTTTTTAAAATTAAAATCGTCG +GAAGTAAAAAAATAGCGCGGATGGAAATCTACGGAGTGCGGAGCGAACAA +ACGCGCGGTAATTCAAATGGGTAGAATAGTCAAAATTGAAAATTAGCCAG +CATCGACCGATTTTTTTAAAACTTAATGGATTTTTTCGTTTTTCTTTTGT +GGTATTTCGGCATTTAGGATTAGATAGCACATTTTAAAGTAAAATTCCCA +TCCAAGCTACTCCACCTTCTCCAGACTGTACAGTTAAACCAATTTGAAAA +GTGTATTGTATCCCGTTTTTTTTTCTGAACAATTTTGAAAATTTTTCGTT +TATCCAGGATACGATAATCATGATTCAAATTCGTTAACAAAAAATGAATA +TATGAGAGCGATTAAAGCATTTGTGTCGGAAAATATGGGTTAAATGGGGA +GAAGGGGGCGGACATTTGGATGGGGTACAAAAAAATATGCAAAAAATGGG +CTAAAAACAATATTTTCAAATTATGCCCGACAAAGGTTCAAAAGTCAATA +TATAGAAATGAGAACATGAGTATTATGCCACGTGGCGGGAAAAATATGTG +GAATGTAATACGATGAGATCCTTGTGAATACAAAGCTTGTGACGACGTGG +CCGAGAAGAACTTTTTAAGCCAACGAGAAAAAAGGGGTTCAAGGCCGAAA +TTTTTTTTGGGCCACCTATTAAGTTAAATTGAAAATTTAAAAAAAACACA +GCGGATCCAATTATTTGCCGAGTTTTGACTTGAGCTCGGCGCGATACGTG +TCGATTGACTGAAAATATTGTTTTTTTTTATTTCCGAATAAAAAATGGTG +AGTACCTCCAAAATTAGCTTTTCATTGTCCATATAGAACTTTTTGATTTG +TTCCACAGTTTTTGTGGCCATCAACTCGGCGATCAACTCGAAATTGTCCT +TGTACCAGTGGAAACCTGAAGGAATTTCGGATGTTTTTGCTTAATCATAA +TCATAATAATCTTAATCATAAGACTTGGAAAATGCGAAATTTTTCGAGAA +TATTCAATTTATCTTCAGATTTTATTGCAACAAATCGATTTTCAACATAA +AATTAATTTTTCCAACTTTTTTTCCCAATTTATGAGAGTTTAAAGATTGT +TTTAAAGCAAACCGCCAACTTTACATAAAAAATTAAAATATTGTGAAAAA +AATGATGAAATTTAGCAGATTTTCTGATAAAAAATTGAATTTTTTTGGAT +TCGCGCTTCAATTTCACATTGTTCTTTTAGAAAAGTCGAAATTTTATATT +TCCAATTTTCAGATTTAAAAAAATTTAAAAAGGAATGAACTTTTCCAAAG +AAAAACTGAATATAACCAGAAATTGTGATTTTTCAGCATTTTTTTTTAGG +TTTGAATTTTTTTTTCATGATTAATCACGTGAAAAGTCAATTTTACCGCA +AAACATTTAAAAAATCAAGATTTTTCAATTTTCTCTGAATTCCTGCAGAT +TTTTCGATGAAAAATTGAATTTTCCTTGGAATTTATATTTTTCGGGTATT +TAAAGTTTCGGATATTAAAAAAAATTTTCAATTTTCTCTGAAGTTATCGA +TAAAAATTATTTTCTGCAAAAAATCTACTTTTTTTCGTTGAATATTCCGG +AAAAAAAATCAGAATTTCAAGGCACATTTCCTTTTCTAATCTAATTCGAA +TAATTCAATATTCTTTTAAAAATTCGGGGTAGAAAAGGAATTGTACCAAT +TTTTATTTTTAAAAGTTAATTTTTCTAATTTTCAAAATTTTCTTGAATTT +TCGAATTACAGATTTTCAAAAAAATTTTTTTTGTTTTTTTTTCTCGAAAA +TTTGAAATCCATACATCTAATAGCATTCTTCTTTTCCTCAGGACTCCAAC +CATAATTTATCCTGACTTTTCCAGATCGATTGCCATTTGTTGCAGTAGTA +TCTAGTTCAGGAGTAAATCTCTCGAATCTTCCCTTCAACGCCATCATATC +TTTCTTCCAATTTGCAATTTCTCCTTTTGGTACACGGCTGTATGTCATTG +TTGCACGGAACATTTGTTGACGGGCTTCTTCATTCAGAATTCTGGAAAAA +TTGATGTTGTGCGATTTTTTTTGGTTAAAAAAAACAATTTTCGTAAGTTT +AATTAACTAATATTTTAAAAAATCTCTCATTTTCTGAGGCACCACGGATT +CAAGATCTGGTGGGATTCCGGATCTGGCACCGTGCCAACGCATTAAATGC +AATTTTTCTGAAAAAAGGGCAACGAAGATCCGATTTAAAAAAATTTTTCA +ATTATTTTTCAAAATTTTCACTAACTATAAGAAATTAGAGATTTTTCACA +AAAATTCCAGTTTTCTGTTAGAATTTGAAAAAAAAATTGAATTTTTCCTA +AAAAATTTGTAATTTTCCGATATTTCAAGCTGTCAAAACCTAAAATCTGA +AAACTGAATTTTTAAAGGAAAAATTTTGAGCATTCTTATCAAAAAATTGT +TTCAACTTTTTCTCAAAATGTTTCAACCTTTTTCTTTCTAAATTCTGAAA +AGCATATCTCAGCTTTTGCTAAACTATTTTTTTCCTCAATTTTTGAGAAA +ATTAAAATATAATATATAATATAGTAAATATTGCTTATTTTCTAATAATT +TTTGGTATTTCTATTCTTTCGTTTTTTTTTTCAAAAATTCCAAATAGTTT +TAAATGTTCATATTATTTTTTTTGACGAAAATAAATTTTAATTTTAAACC +GGAAAATTGTTTCGTAACTTTTTTTTTCAAAAAATTTGAATTTTCGACAT +GAAAGATGTAAAGTGTAATTTAAAAATAATAGTGCAGGTATTTTCAGTTT +ACAGCAAAAGTCAGTTTAAAAAATTTCGACTGGTTTTCAAAATGAGTTTC +CTTATTTTTTACACGTAGAACTTTTTTTATTTTCCGATTTTTTTTGTTGC +GCAGAAATTTTTTTTCCGCAAAATCAGGAAAAATTCAGAAAAAGACAGTC +AAAAAATTGTAGATACAATTTTTTGACTGTCTTTTTCTGAATTTTTCCTG +ATTTTGCGGAAAAAAAAATTTATTTTTTCATGAATAAAAATCGAATACCC +ATCCAATTCCACAAACTTACTCGTTCTCCTCCATACATTTCGTTTGTTTA +ACTCTCCAAACAAGTGGAACACACATATGATGTTTTCTCTTGATATTATC +AATTAATGCCAGTGCAGCCGGTGTATCGAAGCACCGTGTCATTCTGCACG +TATTCTCATCGATTGGATCAGCTTCAATCGATTGCTCCACAATGTAGGGG +CCTGATGGTTTACGGAGAAGGCAGTCGTCTGGAGAAAAATAGAATAGAAT +AATGATTTTTAGGTTATTTTACGTTTAAAAATCTAATTTTTAAGACGCGT +AAACGTTGAGCTCATTTATAAAAATTCGGCAAACCGGCAATTTGCCGAAA +AATTTCGGAAAATTGTCGGTTTGCACATTTTTTCTTGAAATTTCAGAACT +TCGATTTCAAACGGCAAAATTGTATACATCCTATCAAAACATCAATCTTG +AAAAGCCAGTAAACTCTATGAAAATGTCTAAAGAAAAGAAAACGGTAAAA +AAATACAGTTTTAAATGTTTCCGTCTTATTAATAACAAAATTCGACAATT +TGCCGGAATTGAAATTTTTTTTTCTCCAATTTCCGAAAAAAACCCACCGA +CCACCATAATATCATCGTCTTCTTCTTTTTCTTTTCCAATTCCAAGCCGT +TTGATCGCTTTTCCGTTGGCTGGCTCCATGAGCTCAAGATATCCGTATAC +ATAAATTTTCATGTCTGAAAGAAAATTCAAATTTCTTCTGGAATCAGTTA +TTCGAAACTAACATTCTGGACATAAAACTCGTTGCCGTCGTTTTGTCAGT +GCACGGAGGCTTGCCGGACGTGGAACACGCATCAAACGGAAATAAAGGAT +ACACGGTTTACATTCGTGACGCGACATTACACGATTTAGCTTAAAATTGT +GAAATTAATTTTTTTTAATAGCTCTTTATTTTTTTGAAAATTTCTCCCAT +GCTTTTTCCATTTTTTCAACGAGTTTCCTTATTTTTTGTCCATTTACTGT +AAGTTTTTTTTGAGAATTTTTTTTTGTTAATTTAACATTTTATTAGCTCA +AAACATTTATTAGCAAAAATTTTATTAGCAAAAAAATTTTTTAATTTTTT +TAAATTAGCTCAAAATTCTCGAAATTTTAAATTTTTAGGGTAAACAATAT +AAAACTTAGGGAGTTTTGAGCTATAAAATGATAAATTGATTTTAAAAAGG +ATGAAAAACTTATTTTAAAAAACCGACAAAAATCGACAAAAATGAAGGGA +ACAGGCAGCAGCTTAGCCCCATGCTTAGCCAGCAGCCCCGTAGCAACCCA +GTATCAATAATATCCCGTGCCAATTTTCATAAAACTGAATATAAATTGGG +TTGATGTTGCTAAAGGGCTGCGAAAAACTGACCTGGGATGAAGCTGGGCT +GCAAGGGGCTGCGAAGTGCTGCGAGGGCAAAGCGCTACAGTGCTAAAAGG +GGGCTGAGCCCAGACCCTCAGGAAAAAACTCATACTCGCAGCCCTTCGCA +GCCCACATTTGCGCTCTGATCGCGTGCTATCCGCGCGCACAGAATTTCGA +AAGTATTTTCCAAATTCGGAATGCGCGCGGAGCAGACGCAATTAGAGCGC +GGATCTGGCACGTAAGGAAGAAGTGTGACTGGAGCACGAACCAGTAATCT +AGTCGCGCCCCGTCCGCGCTCCAGGAGGAGCGATTTGCCGAGCAGTTCAG +CCCTTCGCAGCCCTTTAGCAACAACCAAATTTATACAGTTTTATGAAAAT +TGGAACGGGATATTATTGATACGCCTAAGCAGCCCTATTAAATAGTGATG +AGGGCGTAAATGAAATTCGCCATTTCCAGCTAAAATATAAATTTTTTGAA +TTTTTTAACATTGATATTCGGAATGGATTCAGCAGAAAATTTGAAGTCAT +TTGAAAATATTTTCCAGATTTCGGTACTCCACTTTTAAAATTGAATAAAA +CTGTAGTCTTTATTCAATGTTTCTTCAAAATTTAAAAAGTAGAATATAAC +TGTGAGAAAATTTCCAAAATTGTCAAAATTTCAAATAGCTGAAATATTTC +ACGGCCCGGCGGGGGGTACATGGATGAGAATTCTCTACCGTATTCCAATT +TGGCTGACTGCGTGCTCAACGTTGAATACTCAGTGTAAACTTTCGTACAC +CGTTGCGTACTGCACAGCGCGCATTTTAATTGACGACATTTAGCAAAAAT +TGAACATAAGATTTTTCGGAATTATGAAGCTCAATTTTCACAAAAATAAT +GAGTTTTTTGTAGAATTTATGAAAAAACGTGAATATATAGATTTTTTGTT +CATGATATTCAAGAAAAAGCGATTTTTAGTTCTTCACAGAGGAATCCTCT +CGCATTTCACTTGCTCATGATGTTTTTTGCTCCACTTTAGGACGATAAAA +ATGCGAATTGTTGATAAAATGAATGAATAATATAAAAAGTGCAAATATGA +CTTCAGCAAGTGTTAAATCCCAAATTTTTCCTGCGATTTTCTGCTAGATT +CCTGGTTTTGAGTAAACAGTCTGATATATTCATGATTATAATGATAACAA +TAACGAACATAATAATAAAAATGGAGAGCACAGAGAAACAACAAATTGCA +AAAACAGCAACTGATATCAGAATTAACGACGACCACGGAAACCGCCTCGG +TCTCCACCTCGCCCACCACGGAAGCCACCACCTCTGTCGCGTCCTCTGAA +TCCTCCTCGATCTCCACCGAATCCACCTCTAAATCCTCCATCGCGGTCTT +CTGATCTACCACGGAAGCCTCCACCTCCACCAGGATCTGTTGAAAGTCCT +CTGAAGCCTCCTCGATCGCCACCTCCACGGAAGCCACCACGATCCGCGGA +TTTTCCTCTATAGCCTTCGAGGCTTCAGTTGTACCCCATTCTTCGTTGGC +ACGCTTCAGATCTCTACAAAAAAAACAAATTAGAAGCATTCAATTATCGA +AATGTGTACCTATCCCGATTTATCGCAATCTGTCTATTCTTCTCCTTCTG +ATTCTCAACTTCTTTAACTTGTCCAGTAGCGGCAGCTTGCTTACGAGCAG +CATTTTCCCGAATCGCCTTCACCTCTGCCTCCTCAGCATCCTGTTGCTCC +TTGACAATCGTAAGTCTTCGAATGACACGTTGCTCACTCTCCTGCTCACG +ACGCTTTTTCATCTGCTTCTTCTTGTTTATAGTCACCGCATTATGCTTGT +GATAGAGAACCTCTCCCTCATCGATTTCTTCTTCAATTTTGACGAGTTCC +AGGGTCAGTCGGGTCCGATCTCACGAAGACGGACGTTGCTATTCTGGCCA +ATTCCGCAGTCACGTCCTTCATAAATGTCTTGTGGAAGTTCTTCTTGCTG +AGGGGGCTGCTGAAACCAATGTCGGCATGATGAGAGTTCCGGTCTTCTGA +ATCCATTTCCTGCGTGGGCTGTGGCGACGAGCTGCACGTCTGAAAATCAA +GTTTTTGTAATTTTTGGGCGCATGATATGGAGCTGAATCATTCGATTTTA +GAATCAGCATGCTTTTATTCATATTTTAGGATCTTTTTAAAAAATCTGGA +CCAACAGTTTTCGAAAAAATTTAATTTTTGTTCAGAAATGTGAATATTCA +CTAAATCGAAAAAAATAATTGCAAAATCCGTCAGCTGAACATTCAAAACT +TATCAATTTGAAATCAGCATATTTCAGTGTATAATTAAAAAAGTTTCAAA +AATTCTGAGACCAATTTTTATTGAGAAAAATAATTTTTCGCTCGAATTAT +TGAATTTTCACTAAATGCAAAAAACAGTAAACTTGGGCCCATGCTACAAG +CCTGAATCTTTCAAATTAAGAACCAGCATGATTTTTTCAATATTCTAGGA +CGTTTAAAAAAAATCTGGACCAACAGTTTTTGAGGAACGTAATTTTTTAT +ACAAAAATGTTCTGATTTTTCACTAAACTCAAAAAAATAGTCAAGTTGGG +CCCATGCTGTACACCTAAATCATTAAAATTCAGAACCGCCATGTATTTTT +TCTTACCAAAGGCTCTTTAAAAAAAATCTGGACCAACAGTTTTTGAGATA +TTTAGAAAAACAACTCACTTTTCGACGTTTTTCGCCTTTTCGTGGCTCAC +CCGGTTGATTTTTGCGGCGATTTGTGGTCTTTCGCTGAAAATATTATTTT +TATTTCAATTATTAACGAAGAAAACAAGAAAAAACGACGAGAAAACATCA +AAAAAACGCGAAAAAACATCGAAAAACCACCGCAACCTCATGAACAAAAA +AAAAGCATTGCAGCCGCGGGACTAGTTTTCGCAACTTTCTAGGCCATGTC +CCGTTCGCCGTGCCGTGTATTTGTTTAATTCCCTTTTTGGAAAAAGTCAA +CATATTTTTCTAACAAATCGTTTTTCTATTAATTTTTTTCTAAAACTCAC +AATCAACAGATCACTTTTTGCATTGCAATTCTCACAATATCCCGACGGAA +CCCTCTCCAAATGATTGACCTCTTTGAATAGTTCATCATAAGTGTCGGTT +TCATTCAAATGCACATTAATCATTGTTTTATAGTTTTGCACTTTTTTCGT +GTTGTAATAGTATTGGATAATGGAAGAAAGCGAGCGTTGGGGCATCTGCA +AAAAATAATGAAATTTATTTTCTTTTTATGATTAAATTAAATTTTCAAAA +ATTCCCTTTTTTTGACATATGCACTTACAGCCGCATGAATCTTCTTGAAC +CGTTTTCCGAAATGAAAGAAGCAAGTGGAGAAAAGACTAATTTCTTCTGC +CGTCCAATCATCATGAATTTCTTTTCTTCTCATCGCTTGAACCATCGCAG +CGTCGAAATCATTTGACTGTTTGTTCAGAATGAACAGAGCCTGTAAAAGC +AGTTAGTTTTTTTTTCAAATTCAAAGTACATTTCCGAAAAATAAAAAAAA +GGCTTGATTTTTTAAAATCTCGAATTTTTATTATGGTCAATTGTTATTTT +TTCCAGAGAAAAACTCATTTTCTCCCAATTTTCAGACGTTTCTCTCTAAA +TTTGGTGTTTTTCCAATCGTACCCTATCTATAGGTAATTGATATCGTCCA +GTAGCTTCTGAAATGTATTCTGTAAGCCGATTCTCGTTCATTTCGTCTGG +AAACGCCCAAATTTGTTGATCTCTGCACGGTTCTTTTTCCAATTGCTCTG +CAGTTGGCTGTATAATCGCCTGATATTCGGTTCCCACGTGGATTAGATTG +TCGACGTTGGAAAGTGGATTTGCTGGAAGAAATTGGGAATTTTTCAAGGT +TTTAAGTGGATTTTCAAGCTATTTATAAAAGCATGAAAAAGCTCAGAAAT +GACTATAAAACCTTTTTTTACGTCGTATTTTTTTCAATGAAATTACCTAC +TTTTAATTAATTGTTCGGCTTAAAACCAGAAAATTGTTTCATATCGATTT +TCCCGGTGAAAATCGAAGGAATCGTCGCATTCTCAAAGTTTTTTCACCGA +TTTGTTTCAATTTTAGCACAACTAAATGGAAAAATCACAAAAATTCCATT +ACAGCCGATTTTCGTGAATTTTCCTACATTTCGAACTAAAAATTGTCCTT +TCTTCTGTTTAAACCGGAAATTCTCTTTTGAAAAACCAATGAAAATTTGA +ATTTTCTGGGCTTTTCTTCGGAAAATTATTCTCGAAATTTATCAATCGAT +CCTTGGGCTTTTTTTGTTCCGCAGAGGCTGGCGGAGTTTACAAGCGTACG +AAGTGGTTCAACTTTTATATAAAGCTTTATAAATGGGACATAGATGAATA +TTTCGAATGCTAAATGCAAAAAGAATCAGTAAAAAAGCGCGCAGCCCCGT +CCTTCTCTGACGAAAAACGCCGTTTAAGGATCGATTGCTAAATTTTGGCA +GTAGTTAGAAGTGTCAAAATTTCTGCCGGAGAGTCGTCAAATTTCACTGA +AACGTAACCCGGTAATTTCCACAATTAATGGTCGATTTTTCGCAAAAAGT +GGTATGTTTGTCAGGATTTATTAGAAATTGTGGCTGTCCAGATTTTAAAG +AGTATTTTTGGGCAAAAATGTCGAATTTTCTCTGAAAAAGTTCGATTTTT +ATCGAAAATTCAGATTTTTTAGATAGTTTTCATCGATTTTCCCAGTTTTC +AGCCTGAGAACTTTACTAACAGAAAGATGTGTCATGAGCACCACTTTCAT +GATGCTCACGAGCTTCAGCTTCTTCATCTTCGTCCTCTTCATCCTCCAAA +TCTTCATCCTCATCGCCCATTGATTCCCCAGACGTTGTTTCGCGTTTTCT +CATGGATCTTATAGGACGAGCCATCTGAAGTTTCAATTTTAGCTTTTAAA +TTCAATTTTACCGCTTAAAAATCGATAATTCTCCCGTACTCTGCTGGTTT +CTTCTTCTTGTTCCGCCTGCTCCTCTGGATCATCTTCCTCCATTGGCTCC +GGCGATGCATTCAACATATTCAAGCCTTCGTCTGAAATATCTGGCCAATT +TATAGAAAAACCGACAAAATAATAAGCCTCACTTTCTTTTCGAGAGGCGT +CTTCGTCAGATGACGTGTACGAATCCATTTTCTGGAATTTGAGGATTTTT +GAATGTTTTTAAACAAACTTTATAGAGAAAACATTCGAAACACTAGAAGT +TATGTTGAAACACGAGAAAATTTTTTAAAAATCCATGAGAAAAACAGTTT +TGAAAAATCTGTTTTTGGAGGCTCTCCGGATTTTGAGGAATCGTCACCCC +GGAGACGCAGATTCTCCGGTAATTTTTCATTCATATTTGAGTTTAAGAAC +AAAACAGTTTAAAAAAATGTTTTTAGTATTTGAATGAAACTTATAATGTA +TTTTTTCTTCCATTAAAACTTAAAAAAAACTACAAAATTATTATGAATCA +AATTTGAAACCGTGAATCAATCTCCGCGGAAGGGCGAGTCTATACTGCTG +CAAGCGCACTCTATCGCAAATGTACAATTGGCGGTTTTTCAAACAGGAAT +TAATCGGATTCTCGTAGTTTATTTTGGATTTCTTTTTTCGGGAACATATT +GGTGTTTTTGCGTTCAATATTCAAATTTAGAGGAAAACTGCTTCAAATAT +TTAGGTAAACTCTTGAAACCGCTGAAAATAGGCAAAAATAATTATTTTTG +TATTTTTTAGGCTACTTTCTATACTTTTGCGTAAATACTATAGTTTTTCT +ATAAAACACCCATTAAAATTATTTTTATAAAATGATTTTTCCAATAAAAA +TAAAATGCGCAAAATGATTCTTTTCCAGAATCCTATATGCGCCTTTAAAA +TCTCTCGGATTACTGTAGTTTCAAAGAAATTATCCTTTATATTTTTAATT +TTAAATTTTTTCCTGAATGTCAAATATTAGGGGAAAAATTATAATAATAT +GTGCTTTATTCATATGAGTGTAGAATTAGTGAAAAAGAAAAAAAACATGT +ATGGACTGTAAAATTGGAATTTTAGCGAGAAAATAAAAATAATATGCAGA +AAAAATTAAAATTTTCAGGAAAAAAGTCAGTAAAGCCATCAAAAACTACT +CGATTTTGAAGGAAATCAGCAAGAAAAATTAGAAAAAAGTATTTTTAAGT +TGGAAAACCCCTGCTTGAATTTGTACACTAAATTGGGCATAAAAGCGTAC +AAATTCGCAAAAACCGGTAAAAATCTGGGGATCGTGATGGATGGAGTGTT +TTGTGAAAAAATGCAGCGAAAAATTGAGTAGACAATTTCAAAAATGTCGA +TTTTTGAAATTTGTGACGAAAAAATTGAACAAAAACTGTTTTTTTTTGGA +ATTTTCAACAAGAAGTTTTATAAATTTTTTTGTTTAAAATTTTGAATATT +ATATGAGTTTGGTTTCACTTAACAGAACAATTCGAACAAAAGTATTCTAG +AAAGGAAATGTGCGCTCCAGCACACTATTTGCCCGTGGAGCGCACTTGTG +TGCACGAACGCTAGCGAGAATGTGTGGTAGAAAGGGAGGGAATAGGAAAT +ATTAACAAAATTGGGCAAAATATGTAAGATTCGGAGAAAGAATTGGAGAA +AAATATGTATTTCGAGCTCCGCGAGCTGATCAATCCAAAGGCTTTCTCCA +TCCTTTTTTCGAGAGGCACATTGCATTATAGTTACACACAGCACGTGTAT +AATGGAACATTGAAGCCTGGAAACGAGCCATCGCTACCATCATTACCACG +TGGATCTGAAAAAATTAAAGTTTGATGATTCGAAAATTTTCTGGAAAAGT +TATGATTGTGAGATAAATTGAATTCTTTGAAAAATCAAAATTCAAAAGCT +TGTAGAAAATTTTATATATTTTTTTAAGCGTATTTTTTCCGTATACATTT +CCAAATTTTTTTGTTACCCAATTTTAAAGATTTTCTTGAATTTTAAAATT +TCTTTCAGTAAAAACTTTTTTTCAACTTTTTGATTTTTTTTCCGCATTTT +TTAAAATTTTATTCAGAATTATTAGATTCTTTTGAATTTAACGAATTTTT +TTCGCTAAAAAATTGTTCGATTTTTCCCGAATTAAGAAAAATATTATTTG +GTTTTTGAATTATTTTCCTGATTTTTTTCGATTAATAAATTTGTAAAAAC +AATTTTTTTTCTAATTTTTGGTTTTGATGATTGTGTTTTTTTTCTGAACT +TTACAGTTTTCAAAGTTTACACCGAACTTCCACATTAAAAAATTCTGATA +CAAAAAAGTATTCACATGATTTTTAAAATTTAAATATTTTTCAAAAAAAA +TAATATTTAAACTGTGTTTTTTTCGGAATTTTTTTTCGATTTTTTCCGAG +TTTTTTTTGGAATTTTTTCCTTTCTGCTCCAAAAATATTCAAATTCAATG +TTGTGTAGAAATTTTATTCAAAAAAAGTGTTCAACTTCTGAGTCTAAACC +TTTTCCGAATCCTTAAATCCTGGCAGAGCTCTCGTGAATTCAGTTGTCAA +TTTATGTGGATAGCAAGCTGCCAGTTTAATGAAAGTTTTAGTTCCTTTGT +CAAGTACTCGATTAATTTTCGAATAATCATAATCATCGACTCGAACACCA +TATAATCCTTGAGTATAGTTCCAAATTGCTTCACGGAATGCAGCAGTGTC +AATTTCATTCTGATTCACGGCGGCTGGTGGTTCTCCGTCTCCAGATGCAT +GGGATGAGCCGGATGGCCTGAAAAATTAATTTTTTGGAATTATTATATTT +TTCTGTTTTTGAAATTTCATGCATCTCGAATATTTTAACAAAATTACCAA +ATTCAACTAGATTTCTTACAACTTTCACTGTGTCGATTTACGGGTTCGTT +ATACGAATTGAATTTGTTTATCGATAGAATATTAAAATTTAGCTAAAATT +GAGAAGAATATAAGAAGAAATTAATTTTTTTAATTTCAAAAATCGAGCCA +GTAAATCGACACGAGCGATCGACACAGTAGTCATTTAAAGACCAGTTTCC +GCCACGAAATATTTCGCGCTTCAAACATGTTGCGTAGTACGTATTCTCAA +AATTGTGCGTTCACGTATAATATTTATGCGAATTTTTGGTCTACTTTGTT +AGAGAAATCATCACTAACATATTGCCAGTAAGAGTCCGAATATGATCGAA +CATTCGATCAAGCCGTGACGTCAGTGTATCCGTATACTCATTCATCGTAT +TATAAACATGATCCCATCCAAATTCTTCAACTCGGAATGGCGGAATATCC +TTTTCAGGTCGCTTTCTAAAATCAATATATCCAAATGTTCGATGATGCGA +GTAAATTGGATAATTACACGGCGGCTCTTTTTCCATAATATCTTCTCCAT +TTTCATCGATATTTGCAAGAAGAAGTACAGGCGAGTAGTTTTTCCGATTG +GAACTATATGTTGCTGCAGGAGCACTAATTAATGATTCAATAGTTTCAGT +AGTCATTGCACACATCTTCGCTGGTGGCCTAGTTTGTCCTTTTTCCGTCT +TTTTCAGCTCACTGATCAAATATTCGACTTCAGTTGGCCGACGATCTGGG +ACTTTTCGGAAATAGGCCGACATTCTCGCCTCCCAATAGTCGAGATCATC +GATATTAAGGAAATCAATCTCATCTTGTGTCAAATCAACACGACGTTCCA +ATCCAATACAGCATATAACTGTGCACATTGCGTGAGTCATTGACATTATT +CCGACGGCGTGGTGGAGAGAGCAAACCGAGAAAAACGCAGGACCACCGTC +TGGCGTGCGGCGAGCGAAGAGCACCTGGAAATTTTCAAATTCTTGAGAAA +AACCTAACATCGTTGTTATACGTTCGTTCTCTTGGCATTGGAGTTGGCAG +AATTTGTTTTGAAAAAACGTTGTTTTTTTTTTGAAAGAACATTTTTTTAT +TACGGGACCATGAGATCATGAGAATTCCTATTTACTGGCGCGAAAATATT +GGCAGGCCACGGCAACGAGAGAGCATATGGCAAAGAGAGACGCATCTTAT +TTTGTCTTGTAATTTTTTTTTAAAATAATTTACAATCCCTTTTCAACTAT +CGTGATTGTAAAATATTACAAATTTCAGAATTTCGCTACCAAATTATTAC +TGGAAAACTAAACTCTGAGAATGCGCATTGAGCAACATATTTGACGCGCA +AAGCATCTCGTAGCGAAAACTACAGTTATTCTTTAAATGACTACTGTAGC +GCTTGTGTCGATTTACGGGTTCGGTTTTTGAAATAATTTTCTTTTCGAGA +AGTGACAGTGATATTCCATTTTCCTTCTTTTCTTCCTATTATTTTATCAT +TATTTGCTTAATTTTAATATTCAATTCATAACTAAATTACTTTAATTCAT +TTCGAGTAGACATTCAAAGAATTCCGGTAGTTTTCGCTTCGAGATATTTT +GCGCGTGAAATATGTTGTGAAATACGCATTCTTAGAATATGGTGTTCCCG +TAATATTCAGAAAAGAAAAGATTTCCAAGAACTTTCTGAAGATTTCAATA +TTTGCAAAATCAGAAACCAGTTCTGAATATTCTTTATTTTTAGAAATTTT +TCAAGGTTTTCTAAATAACTTTTCTAAATAACCTACCGTATTTCTTCTAT +TAATATGGCTGCAATACTATTTTTCGATGGTCTTCCCGCTTGCAATACTA +TTAGGGAGTGCAAGTCTAATAGGGAGTGCCATACTATTCTTCAGAAAATT +TTTCTGTGTTGGGGCTTACTAGATTCTACTTGAAAAAACTCCAATTTTAT +TTGGAAGTATAGAAAATTTGATTGAAATTGCAACAAAAAGGTACAATAAC +TTCAATCTCTAAAAATTTTGTTATAAACTGTTGCAAAATAGGCAAAAAAT +GTTATTAAAATTTTAAAATTAGTAAGGAGTGTTTGCAACAAAAAAAAGTA +GGTGCAAGACTATTAGGGAGTGCAACACTAATAGGGAGTGCAATACTAAT +TTTCGGAAGGTCTCCGAGGGGCAATACTAATAGGGAGTGCAAATCTAATA +GGGAGGCCATATTAATAGAAGATATACGGTATATATAGCTTTGAAAAATC +GGAAAATGCCTAATTTTTACTTTTTGAGGTTTGAAAATCTCTAAAAATTC +AATAAAATTTCAAATTACCGCTAGATTTTTCCAATGAATCATCCATGGTC +TATGACAGAGCATTCGATTCAAATAATCCAATTTTCGAAATTTCATGTAT +GACCAATCAATGCCCAACAACCACATTTGTTGTCCACCCTTTTCCAGAAA +TTTGCGACGATGATGATCCATAAGTGATAGGCATCTGTGACGTGATGCAG +CCATTAGTGCAAGATAATGACGAGCCGAAGCTGGTAGATCACTTATATCA +ACGAACATATGGCCATAACTTCCTGTCATATGAACATGTAGAGTTGGGTG +TTTACATGTGAAACGGAATAATCTGGAAACGTGAGGGAAATTAGTTCGAG +ACGGGGAGGGGCAGGTTGGCGGTGCCAACCGACAGCCGAACATTGGGGTT +TCTCAGCTGGTAGCGCCAGCCGACAGTCTACTGCAGTACTGCAGATAAAT +TTTCGTCGGCTGTCGGCTGGTGAAAATTTTCATGAAAATCAATAATTTTA +AAGAAATTGTTGCAAATTTTTCCCAAACTTGACCAAATTTGTTGGCTGGC +TGTACCAGCCGACACCCGAAATTTAGAACATTGATTAGAGGCTGCTTGGC +AGAAATAATTTTAAATTCAGAAATTCAATTCGTTTTCAAAAAATATTTTT +TAAAACTTTACCGATCAACTTCTGGAATCGGATCAAAATTGAGCCAATCC +ATGGCTTTTCGTCTTTTAGTTGTAGTGTGCATTGTGTAGATCTTTTTATA +TTGCTGCGAGGTGAGTAAATGAAGAATTTTCGCGACCCGTTTCTGAAAAA +ACTCAGTTTTCTAAGGAAATTTTGAAAATAAATTCGAGAAAAAGAAACTG +AGTCAGCAAAAGAAAATTGGAAATGTCTGTCTGGAAATATTCGAATATTA +TATTCAAAAGTTTTCAAAAAAACAACGAAATTACAAGCAATTGTGATCAG +AAACCGCGGAAGGAACTGGACGAAAAAAATTATCTTTGAGACGAATCTCT +TTGCATCTTTGTGATCTAAAAGATTAATAAAGGTTGTCATCACATTTTTC +GAGATTTGGGAATGTGATAAGGGTGAAAAATGGAGATTAATTGTGGTAAA +ATGAGGAAAAACCTAATTTTTGGTGAGAAAATTGTGGAAAAACTATAAAA +GAATCTTTATGGAGTTTAAAACTCAAGTTTTTCACGCTTTTCCGCACTGT +GCGGAACGTTTTTTGAGAGAATTTGGCCGAATTCGGTGATTAAAAAAATA +ATTTCAAAACTTTGCGCCTCAATTGTGATGTATTACCGTACTCTGTTGCC +ATTCCACCAAAATTTCCTTCATTGTTTTGCCATTTTTCTGCATAATAACT +GTTCTGGGTTTTTTTGCTTCATGTGCCCAAATGTACGAATTTCCCTAAAA +ATTATACCTATTTTTTCAAAATTTTTAATCGCTAGAATTTTTTTTTCTGC +ATTTTCTTTAAAAAAAGAGATTTCTCGCAAGTAGAAGGAGAAAAAATGTG +TGGCTATACTTCTTCTTAAAGAATGCACGACTAGCCATAGCTCAAGCCCC +CTCTGGAACGTTCCATCTTCCTCCCATTTTCCCACGTTCAAGAATCATCA +GCTTCTTCTCCCTCAGCTTCTCTTCTTCTAAAACCACAACTAGACAAATG +TTCTTGTTTTCCACCCTATTTTTCACATAAAACCGCCGAGAAACCCGCTA +TCACAGACTCAATGCGCACCGGAGGGGCTCTTTGTGTGTGTGTACTGATC +TCTGCGTTATATTCGAACACCGGCGCACACTCGGATTGAACCAGAGGGGG +GGGGGGAGGGGGGGGGGGGGGTGAAAAAAGAGAAATACTCTGAAATTCCA +TAAAATCTAGAAGAAGAAAGAAAACAAAGGAAAAATTGGACATTCCGAAG +TCAGGCTAAAAAATCTCATAAAACAAAATCTATTCGATTTGTGACCATTT +TCATCTATCTCTCTCAAAACCCGAATAAACAAAGCCTCCCGTCCCCAAAG +TGTGCTCTCATGCTCTTCTGGAGCCTTCTAGACTGTCTGTAGAGCCTAGA +GACAGCGGAATTGCACTGAAGTGATGGAGAGACGTAGAGAAAACGCCTGA +AGAAAAAAACGAACACTTTGGTGGAGGAGGAGATGGCTTCCCTCCAAATA +AACAACAATTTCTATCGTTTCTCTGTGATTGTGTTCTCTTCTATGTATAC +TGTTACGATATTGAACAGGAAATTAAATTGAGCACTCTGAATACATAATA +CACAATAAATAAATACAAAAACTATAGTTTCAGCACAAAAAATTCGAAAA +AAAAACGATTTTTTTTGTCCGAGAGGAGTATATGGCCTAGAAAAAGAAAA +CTCGGCCACTCTGATGCAATAAATTTAAAAAATTATGGCCGAATTTTAGA +TTTCTCAGGCCAATTTGATACGTTTCTCGAAAAGCCATAAATTAGTCGGT +TTTTCACGGGCTTCTTGCCTTCCTCATTGCATTTTTCGCGCTCCATTGGC +AATCTCCTGCTGGACAACGCGTGGGAAATCGTGTGCCCCACACGGGCAAA +TACATTTTGTTTTACAAAGAAAACCGTGCCGCGACGCGACACGCAACGAG +CCGTAAATCTACCCCAGATATGGCCGAGCTCAAATGGCCTAACCTGTCAA +AATCTTCCACTTCAAAATATGAGGGAAGCCAGAAGCGCGTGTTGTTTCTG +AAAAAAAAACCCGCCTAAAGTTGATTTAAATTATCGTTTTTTTGGAAATA +ATAAAATCGATGAATTTGTAGATTTTGATAAATTTCCGATAAAAAAAAAA +TTTTAAAAGAGGAAAAAAAATGTTTCTTCGCCCTTTAGTACCAAAAATAC +GCCCAACTAACCAAATCGTTCTTTCAATCTTTTTTAAATGTTTGTGCGTC +TATAATTGTCGCTTCAGAAAACTACACAAAACACACACACACACAAGGAG +AAGAAAAGAAAAAACGTGTTCCATGACCTGCCACTGGGATCGATCTGTAA +AAGAATTGGGGAAAATTGAGGTAAACTGGTTTTTTATCGGGAAGATTTTT +TCGGAAGGATTGAGATGAAAGTTCGAAAGGTAATTGGCAAAGTTGAAAAT +TGAAAAATTCGAAAAAAATCTCAATTCTCTGCTGTAACCCCCAATTTTGC +GTCATGGCCTAGAGTATGCAGCGTGGCCTAGAAATTCCTAACGTGGCCTA +AAAGATCACGGCGGTACCTATGATTTTCTAGCGTGACCTAGAATATACCA +GACCTAGAATTTGATAGCGTAGAATTTCCCAGTATATCCTAGCAGTCTTA +AGTGACAGTTTCTCAGTACGTCCAAGAATTCGTCAGCATGACCTAGGATG +TTAAAGCGTGGCCTACAAATTTTCAGAGTCTTCTAGGATATTCCAGTCTA +AAAATTTTCAGTGAGGCCTGAAATCATCGCGTGTCCTAGAATGTCTAATA +ATTGCAAAAAAAAGATTTGAAAACTAGTATTTACCCTAAAATTGCATTTT +GAGCATTATTTTTAATCTAGTTTTAAGGAAAAAATCAGAAAAAATAAACA +TTTTTTGATTAAATCTTCCGATCTACAGATAGAAAGTGTGCAAGAAAGAA +TGCAACATTGTGCTCGGTGGAGCAAGAAGATAAAAGAAAGAGAAAGAAGG +TCCCCCACCCCTCCAGTGGTCGAAACAATGATAAATTGGACAAACGGAGG +ACCAAGGGGCCGGGCAGACACAAGAGAGAGAGTACGTGAACTGAGGAGGG +TGTGCAGGGAAAAATGGGATGGGGGCAAATCTAGTTCAAAGATGAGACAC +TTTTCAGGATCTTTGATTCTGAGAAAAATTTTGAACAAAAAGAATACTTC +AATAATTTAATGGCACATAGAAATATTTTCAGATTGTTCTTCAAAAGAAA +AATATTTTTATGCCCGGAAAATTTATTTATTGCATTTCTTCCAAAACAGT +GGCCGGTCTCGACACGACAAATTTTTGTTAAATGCGAAGAGGTGTGCGCC +TTTAAAGAGTACTGTAATTTCAAACTTTCGTTTTAATATTTACTTGTGGG +AAAACATTAATGCTTAACGAAAAATTACAGTACTCTTTAAAAGCGCACAT +CTTTTCGCATGTGACAAACATTTTCGCGTCTCGGTGACAACTTTTAAGTT +AAAGGCACATAGAACTTTTCTGAAGAATTTTATTTATTTTTCTGAAAGTT +AATTGCTACAGTATCCTTTTTCAAGTCGCACCGAGAGCCAAACTGTAGCA +AATCATCAAAAAAAAGTCGACAAAACGTGCCGAAATCAGTAAACTTGAGA +GCTTTAAAACTCTATTATCAGTTCTTCGCCAACAAAAAAAAAGAGTACCG +TATCAAAAACGAACTTCGACTTTTTTGGCTCTCCTGCATACGGACATGAT +TCTGATTGACAGTTTTCATGTTTTTTTTTGGGAGTTTTATTTATTGTGCA +TTTAAAAAATCGTATAGTTTGATGCGTGGCCTAGAATTTGCCAGTGTGAG +CATTAACTCTCCACGGTAGCCAAGAAATTTTCTACGGTGGCCTAAAAACT +GCCAGTGTAGCCTAAAATATTTTATTGTGGCCTAAATTTTCCAATGGTCT +GTTTTTTTTATAGTTGCCTAGAATTTCTTTTCGTGACCTAGAAGCGTACA +GAGTGGTGGCCTAGAAAACGATTCATGGCAGAGTTTTGAAAAAAAAACGA +AATTTCGAGAAACAAGCGAACAAAAATCGTCTGTCGAAAGAGTATTTCGA +ATGCTGGGGATGCAAATCAGCAAATCATTCAAAAAAAACTTTTGTGATAA +GAAATCAAACTGATAAGCCAGTGTCAAAGTCTCGAGGATTAAAAATAGCA +TTTCAGGTCGGGGTACGGTAGGGTTTTTGTAGAAATTAATGCAAAATTTC +AGTGGGAAACGAGTTCGTGGCCTAGAAAAATCATGTCTGAAAAATTGCAA +ATGCGCTCCCCCGAAATGGTTAAAAATTTTCAATTGATAGCCTATTTGAA +GTGGCGGCCTAGAATATCAAATAATGGCCTAGAACTCAAATTGGCGGCCT +AGAAATCAAACTAATGACCTAGATTAGGGCATCTTGTAGGCAGCTTAGAT +CACCTATTATAGGCAGGTGTAGGTAAAATTGTAGACAAATGTAAGTTTCT +TTGAAGATAGGCGTAGGTTCCTTTGCAGGCATACATAGATCATTTATTAG +GCAGATGTAGGCCTGATTGTAGGTACAGTGCCGGCCAAAAATATATCCTA +TTTTTGACTTTTGATAAATTTACAAATTTTCCAAACGAGCACAACTTTAA +AACTAGAAATGTTATCGAAAAAAGTTCAACTCATGTATGTATTGCCCATA +ATTACGTCTACTCGTATTCAATTGTTTGTTGTTTACTAGTGTCACGACAA +CAAATACAGCGGCCGACATCTCGTAAGCCCGTTTTTGACAACGTTTACTG +ATTCGGCCGTATCTCGAAAACTAATTTTTTTCTGAAAATGTTGTTAAAGT +GAAATAGTTTTCATGTTATTTGTTATCATTTGTGTTTATTCACTTTGTTC +TGAAAAATCCAGTAAAAAAGTTATGGGAGTGCAAACTTGTCGCTCACTGC +CACTCACCCGCTACAATCAAAAATCAGGTTACTTATAGTTAGTTCTAATT +TTTTTTTTGTAGAGCATTTTTTAGAAATAACACATGTAAAATCACAATGA +AGCTATATTCAAACACGATATCAAGATTCAGGAAAAAATTCATTGTTTGC +GAGAAATGTTCAAGGCGTGGCCAAACACTATTCAAGTTTAATCTCTCATA +ACTCTTTTTCTGGATTTTTCAGAACAAAGTGAATAGACATAAATGATGAC +AAGTAGTATGAAAACTATTTCACTTTAACAACACCTCGAAAAAAAAATCG +CTCTCGAGATACGGCCGAATCAGTAAACGTTGTCAAAAACGGGCTCACGA +GATGTCGGCCGCTGTATTTTTTGTCGTGGCACTGGTAAAAAACTTAAAAA +ATTGAATACAAGTAGACGCAATTATGGGCAATACTTCATCAGTTAAACTT +TTTTCGATAACATTTCTAGTTTTAAAGTTTTGCTCGTTTGGAAAAGTTGT +AAAGTTATCAAAAATCGAAAATGGCATATGTTTTTGGCCGGCCCTGTAGG +TTAAATATTTTCGTTATCAGGTGTAGGCATGAATCGCCATGTAGGCGGGC +GTAGGTATCTTCTAGGTAGGCGTAGGTTACCTGAGTCAAATTATAGGCAG +ACGTAAGTAATCATAAAAATTGACACTTTGTGGGCAGGCGTAGGTCACCT +TTTAGACAATCATAGTTAGCTTTCTAAGTAGGGTTAGGACACCTATTATA +GGCAGGTTTAATTCCTCTTATATGTGTGCGTAGAACACGTTATAGTCAGG +TGTAGGTCACTTTGTAGGCAAGTCTAGGTTCTTCTTTCGGCAGGCGAAGG +TCATCTTCTGAGCAAGTTAAGGTTCGCCTTGTAGGTCGGTGTAGGTTGCC +TCGTAGGCAGACTAAGTTACCTTCTGGGCATGCCTAGATTGACTAGTAGG +CAGGTGTTGGCACCAAGGGTGTCAGTGTCCCGTAAAAATTACAAAAACGG +GACAACGGGATGTCCCGTTCCCGTGAAAATTTTAAAAACGGGACAACGGG +ACGTCCCGTTCCCACGAAAACACCCAAAAAACGGGACAACGGGACATCCC +GTTCCCGTGAAAACGCTCAAAAACGGGACAAAAGACGTCCCGTTCCCGTA +AAAATGACAAAAACGGGACACCGGGACGTCCCGTTCCCGTGATAATTTTG +AAAACGGGACAACGGGACGTCCCGTTCCCGTGAAAACACCCAAAAAACAC +CCAAAAAAACGGGACAACGGGACAAACGGGACACGGGACTTGACACCCTT +GGTTGGCACCACTGAAGAATGCTGAAACCGACTTTTTTTTCAAAAATGTC +CTGCTCAACGAGCCGAATGCATTTTGGTCGGATTATATTGGCACACCTTT +TTGCCCCCGAGAGAATCATTGAACAAAATCTCATGCACTTTCAATTTCAT +TTTTCATTTCATCAAATAAAAAGATTCGGGAGGATTTGATATATATTGGA +AAAATAAATGAATGGGGGATTTGTATGGTGGGGGAAAAGTGCACACCCGG +AAATGAGCAGTAGGATTTTGAGCAGGAAATTGAAGGAGCTGGAGCAGGAG +AGCAGCTACAGTAACCACCCCTTCACAGCAAAACACATGGCTCATAAAAT +TGAATATTTGAAGTGAACTACTAGTGATAAGCGGTGAAACGGGGTATGTG +GCACTAATTTTTTTTTCTTCAAAAAACCCATTTCTTATCACTTGTGTGCA +GAAGCATTATGGAGACAGGCAGGAGGCAAGTGGTGGTCTAAAAATTAGAA +AAGTTCGGCCACAGCTTGCCCGATAGGAGCACACGGGCATACTGTTTCAA +CAAAAATTCGAAAAAATTGGAAAATCCCGGAATTTTGATTCCGCGGAATC +CGACGATTAAAGAAATTCTCGCGTTTCTGATTTCACGGAAATCGGTATTC +TCGAAATTTGGTTTCTGCGGTGTCTATTGTTTTGGAAATGTTGTGTTCAT +GTTTTATGAAGAACAATATAATATTATGTATAATAGATATTATATATTAT +ATATAATAGAATAATTTTAGTAAAAACCCCACAAAACTTCGAAAATAGAA +GAAATTCTCGCGTGTCTCCAAAATTACAAAAAAATCAGTTTTTTTCCTTT +ATTTTATATTACACAGGATATTTATATCAATTCAGCAAAAAAACGGGCGG +GACAGAAAATTAAGAAATTTGCGAATATTCGTTCCCACGGAAGTAAATTT +CCCCGAATTAGAAAAAATTCGAATTTTTACTGGATTTGTCTCAAGCTTTT +GAATCTAGAAACATTTTCTAGTAAAATCTCTTTAAAAAATTTTTTACACC +AAAAAACTTTTTAGGCCCTGAATTCTGCGAATTAAAAAATTCCGCAAGAG +ACCACACAAAATCGAGAGACTTAGTTAGACAAGTAGAGGGAAAAATAAGA +GGCAACAAATCATCGAAAGTTTTTTTCTGCAGAGAGAATGGGGGAGAAGT +TGCGGCGCTGAAAGAGAGAGAAAGAGAGAGAGAGACAGAGAGGGTGAGAG +ATATAACAGAAAACCAGGATAGTGCGGAGGAAGAGAAGAAAAAAGTGTTA +GAAATATTTGTCCGTCGACGCCTTCTTCGTCTTCTTCGTCGCCTTCATAA +ATGAAACTATGCATTTTCCTCAGATATTGCCTTACTATTAAATGGGGCCC +GGGCTAAAGGGTGTGGCCGGCCGATCCAAAACGGTGGCCTAGAAAAATAT +CGGCGGTGGCCGATATCAAATAAAAAAAACATCGATAGTTATGAGACCAT +AATTTTTAGTTTTTCAGATTTTGAGTCACTTTTCTGATTTTTATCCCAAA +AATAGAGCTCTTTGCTGTTTTTCTGCAGAATCAGCAGGTGGCAACTTGGT +TTTCGGAATTTGTGCTATTCTTAGAAATTCCCGACACAGCATCGAGTTTT +ACTGGAGAACACGTAGCGAGCACAGAAAAAGGAAGGAAAGACAAGAATTG +GCTCGGCGAGCAACCAGAAAAGCAGCAAGAAAAAACTGACCGAGCAAAGA +ACAGCGCGATGGGGCTCATATATATCTAAAAATGGATGGATGGAGAGATG +AGAGACAGCAGCAGTATTCGGTCAAATGAAGACAAGCCAATTTCGAAGCT +TATTTGGTATTCATGCGTGTCTTTTTTTTTCTTGCAAGAAAAACTGATCA +TTAGCAGAAAATTCAAAAAATATTGGTTGTCCGAGAGGAGTACAGAAATT +AAAAAAAATCGTCCGAAAGGAGTACAAAATTCAAAATGTCTATTATCCAA +GAGAAGTACAAAATTCAAAAGTGTATATTGTCCGAGAGGAGTACAAGATC +CAAAATATGAATTGTCCGAGAGGAGTAAAAATTCAAACCACAAAAATCCG +AATTTGCCAAGAAAGGGGCGGAGCCTGATTCGAGTGGAGTGTCGTTGCAA +AACGCAAAACTTCAAAAACATACGGTTTTCAAAATCTACCTCGCCGACCT +ACCGTAACCCTCTAAAATTTCTAGGATCAAATATCATCGCAAGAAAAGTG +TTCGTTCGAAACGAAAAATATTTCTGACGCCTCATCAATCATCATATCAG +TAACAAAAACCTGAGAGAGACGGAAACAAAGAAATATATTTTGAACCGAA +CAGGGATCCTGCAACAAATCACGTAATGGACAAAATGCGCCCTATTGCTA +AATATGCAGCAAGACGCAATTGCATTCTTCTGCCAGAATATCGATTTTTA +TACGTACTTATAGTGATAAAAAAAATGCTGAATTATCGATTTTTAATTCC +CCGGAAAAATGTGCGACAGAGCGTGTTTGCATTTTTTTTTTCGAATTTTC +GTGCAGAAAAACCCGTAAGCATCGATTTTTCTCAGTAAAAATTTCTCGCG +CCAAAATTGTTTCTATTTTTTTCGGGAAAAATCGAAAATCTCCAAAACTT +CGGTGGAGCGCACTTTCTGGACCACAATTTTTGAAGGGAAACATCACTTT +CTGCGGTTTTCAATAAACGAACAAACATCAACAAGAAACGAGAGAGAGTT +TTTGTTGACTTTCAAGAAAAAAATGGATATCGAATTTCTGTGCTCCATTT +CCCTCTCCGGGAAATGGCGCGGGGAACGTGCAAACAATGCGAGTATGTCT +AATGGCTCTCACGTAGATCGAGAAAGTGGAAAATTTGCTAGTATAGACAG +TTTAAGGAGGCTCTTTTATTCTATTGGGGAACCGATTTGTTTATGTCTTG +CCGTGGAGCGTAGTTACTGTAATTTTTTTGCAAACGTGCTCCATCGAACA +GTAAAAAAATCAGTATGCATACTAGTATGTACCTTTAAATAGCTGTAACA +CGAATTGCCTGTGAAAATAAAAATCTCGGCAAGTTCTCTCCATCGGATCA +ATGTAGGGAATTTTGCTGTTTATAATGCAAACTCGCTCTAATAAACTACA +ATTTTCGATCGGTATTTCATGCATTTCGACTGATTTTCGTTATTTTTTAT +GTACGCTCTCTATTGAAACACGGGGCCCGAGAAAATATCCAAAATCTAGA +GAGGTTGTATTGCTTAGGCTTAGCCGAAAACCTGTAAAGATTTTTTAAAA +ATTGTTCAGCCTGCGATGGACGACTTTTTGTAAAACTTGGCCACCAACTT +TTTTACGGTGCGGCTACATCGCATTTGGGTGACCTTTAATGTGTTCAGGG +TGTCTAAACATGCACCCAAAAGAGAGTGTCATTTTTAACGCGAAACAGCA +TCAATCCAAACGGGGCGACAAAAAATGAGAGAGAGAGAGAGAGCGGGCGC +AATCTAATGTTTTATCAAGTGTCTCTTCTTCTCCTCCGACCTCGTTTGCA +TCCCCCTAATTCATCATTCGTCGGTTTGTAATACAGAGAGAGGGACATAG +TGAGTGAGAGGGAAAATTGAGGAGATTCAGAGAGTTAGAAAGAGAGAGTG +AGAGGGAACTTCAACTTTTTTTTTCAAAAGTTTTGGTCGATGATTTTGAC +ATTTGATAAAACTGAATGAGAGATGATGCTTAGATAAATGAAAATTGATG +AGATGATATTTATAAATGCACTTGCGATGTTGTTTTACGTGCAAATTGCT +GATTAGTCGAGAAGTTGTGATTTTCGTGTCGGGAATATTTCACTAGGAAC +GCCCTTGCGCCTTTAAAATGTAAAGTAGCATAATTTATTTTCAGAAAATT +TAAGCGTTGGAAAAATAAGTAGTGCGCAACATATTTGACTCCCAAAATGT +TTTGTAGCGAAAACTACAGTAACTCTTTAAACGAATACTGTGGTTCTGGT +GTCGAGTTACGGGCTGCCAAAATTCGAAAGTAAATTCATTTATAATCGAA +CCCGTAAATCGACACAAGCGCTGCAGAAGTCATTCGAAGAATTACTGTTG +TTTTCGCTACTAGATATTTTGCGCGTCAAACATGTTGCGCAGTACACATT +CTCAGAATTTTGTGTTCCCGTGATATAACAATTCATTTTTCTGTCTATAA +CCTCTTTCAATTATAAGAAACCATTTGCAGCGAAACACAAAAAATTTAGC +CGATTTCTATTTCACCTATAAAATTCGCGTCAAATGGCCCGCGCTGTCAA +GACAGTCATAAAACCAAATGTTATGCAAATGGCGTAAAATTCAACAGTGC +CCGCCCGCATGGTCATTGATCGTTTAAGAAGAATGGAGGAGGGTGCGGGG +AGCATCATTTCCTGAAATGAGCCCAGAAGCGAGAGATTAGAGAATTAGAG +AAATGAGAGATCAATGAGGAGAGGGTGAAAGGTATGAACAATGAATAAGA +AAGGGATGGAAATGATCACAGATGGAAATAGATGGAATAATGAAGTGCAT +CGATGCACCATTTCAGATTTTTCGGGCTTTTCGCAGATAATTGAGGAATT +ACATTTTTCGGGCTCCATCGATAATACCCTGCCGGACAACGCGTTGGAAA +GTGTGTGTACTCCACACGGGCAAATACCTTTAGTTTTACAATGAAACCCG +AGCCGCGACCCGACACGCAACGCGCCGTAAATCGACCCCAGCCGTGGCCG +AACCAAAATGGCCTAATTCGTCAAACTTTTACATTCCAAAATATCAGGGA +AACCAGAAGTGCGCGTTTCCTGTTGTCCGAAAAAAGATTACAACAAAAAA +GAAGAAATGGAGCATTTGCGCTCCATCACACTCTCAGACAATTTCATTTT +CCACATCCTATATATATTTTGGTTTTTCTGTCGTATTTTGTTTTAATTTA +TTGGTATTTCGTTCAAAAATAATTATTTTGACTGTATTTTTGGTTGCATA +CATGTAGAACTGCTGTTTTTTAAGATATTCTGCCCATTCAAGTTTTTCAG +TGTAAAATTGATATATTTCATTCCAACTGAAAATGAGATCGAAACGATGG +AAAACCTCGGATATTACTGATTATGGAAAGAAGAGAAAAGAATCGGAAAG +TTGTGGATCAAGTTCACCGATTCTCGAAACACAGTCATCTGGCGGTGCGG +AACTTGACGAAGTTACTGAGGATGAATATTCTAGTAATTCGAGCAGTAAT +GAAACTAGCGACGAAGAGGAAAACTCAGAAGTACCAAATGTCTTATCTAT +AACAGAAAGAGGTAAGAATTGCGTCTTCTAGTGATCATACTTTTCGCCAG +ATTCCCTAATGTAATATATTTTGTTGTAGAGAAAAGTTGGCAAAAGTTAA +CGGAAAACGATTTGGGACGAATTCGTTTCATCTTGAAGTACACTAGCAAT +ACTAAAAAATGCGTGAACGAGTATTTTCAATATAATCATGGGCAAAACAA +TGAAATTATGAAAAGTCTATTATTGGATACCGATGGAACTATGACTGCAA +AGGCTTGTTCGGAATGTGCCTACGATTTGAATCAGTAAGTTACTCTCTCG +ATTTATTCCCAAAATTAATATGTGCTTCAGGTGCCACTGCAAAAAACCGC +TTCGCTTCATCAATGCTCCGTGTGGTTGGTTTGCTATTCAAAACTATAAA +TAGTTCACTGTTTCCGTTCAGAGGTCATCAACCAAGTTCTTCATGTTGAA +AATGCGGAGCCCACCAGGATCAACCATGTAATCGCAACACTCTTCCGGAA +TCACATTGGCGAGATTTTGTTGGTCCACTCTATTTCTGTGCGAGAACTGT +GATAAAACTAGTATTTTCAGCACAAAGGCTCGAACTGCGGAAGCTCGCGC +ATCTGAAGAAGCTCAAATCAGGATTCAAATCCAAGACAACTCGAACGCAT +TCCAAAGATCGTATCATAACGATCCACAACCTTCATCAGCCGAAGAACAT +GAGGAAGATATCGTGGTGGATGGCTGAGTACGGAGCTCAAATGCCTTAAG +GCGAAACAATTGGTTTTTTAATTTGCTGGTTATCATGTTAGATTTTGAAC +GTGTTAGGTCTTTCAATTGTTTTTTTTTTTCGAAATGTTGTTGTTCTAAT +AAATTTGTTTTATTTAATCAAACGTTTTTTAGTCTACTACGGGCGTGAAG +CCAGATATCAGTGGTATCTTCTTATCAGAAGCTGAATCATTTCCGGTTGA +CAATGTTTGAAGGACATAAGAAAGGCTGTGTTACTGATTTCGACCATTGA +TTTGTTTATATATGGATATGTTCCACTGCCTTTTGGAAAGGCAGTATTCC +CGGTATATATGGGCCTAATACGGAATCTAAAATAACCTGACACAAACCTG +ACGTTGACCTGTTGCCGGCCCGCGGCGGCTTAGTGTCAACTTGACAGCGG +GTCGCGATTTCACCTGCCAGTTGTTCTCCATTCAGCAGCCAGCGACCTGC +TGGCAGGTTGCCACTAACCTGACGCGGTTTACCTGTGTTATCGGCGCGTG +CATAGCTTAGTGGTTTCAGGAAATGATGCTAGTAATCAGAAGATCGGGGT +TCGGGAAACGGCAGGGGCTTGAAGGTTAGGTTCTATGAAGCAGGGCGAAG +GGTTGACAAGGAGAGGCAATAAGCAAGTAGTAGGGGTTCTCTAGAAAACA +TTTTTGTCTTTAATATGCGTTTCCTACTGATTTATTATTGATATTTGGAT +CCCCTTTTCTAGAAAAAAAAATCAGAATCAGCAGAAAAATTTGAGAAAAA +GTCATAGCAAATCAGAGTTGGTCAGAGTAAATCAGAGCTAGTCATAGTAA +ATCATAGCTAGTCAGAGAATATCAGAGTTAATCAGGGTAATAAGTAGACC +TAGTCATAGTAAATCAGAGCTAGGCATAGTAAAGCGTGGTTACTCCGAGT +AAAACCACACTTGCACCGAACTGCGGTTAGTGTGCTTTACCATTATGTAA +CTCCGCTTTTTACTCTGAGTTAGTATGATATGGTTTGTCTGAGCTGTGGT +TGGGCTTCGCGGGAAACTTGAATAATTCGAGACAAAATCTAATTTTAGCG +AATTTTCTTTAATTTCTTTGAGGTTTCTACGACAGAACTCGAAAAATTTC +GGGTTTTAATGTTTACACATTTTATTTAAAATTGAATAATCAACTGCGGG +ACTCCTCGAAAATCACATGCTCATTTAAATTTTGAAGTTCAAACCTCAAA +AAACGCGCAAAAACCAAATTCAGCTAGGATATCAAATTTATGATTGAAAT +CTATATTTTGATGCGGTGTTTCTGAAGTTTTCGCGATAAAATCCGAATAA +TAATTCCACGTACCGTATATTCTCTATCTAATTTCCAGGTCATTTTTTAA +TGCAGCACTATTAGAGACTGTCGTACTACTGGAGACTGCAGCATTAATTT +TCGAACGGCTACTGTCAATTATAGATCACTAGTATTTAGTCACAAAAGCT +AATTTTTTAAGCAGAAATTCATAAAAATGTTTTCAATATTGCGAACTTTT +GTAACAAAAAGACCCAGTAATTCAATTACTTTCGTAAATTATCAAAAAAT +CATCAAAAATATACAAAAAAATACCAAAAAATATTGAAACTTTCAAGTGA +CTCTTTCAATAGAAAATGGGGTGCAGCACTAATAGAGACTGCTGCACTAT +TTTTCGGACCCTTTTTGAATGCAGCACTATTAGAGACTGCAGTATTTACT +ACTGGAGATGCAGCACTAATAGAGAATATACGGTATATACGTAATATATT +CTTGCAGAAAAAAGTACGATTATCAATGAAAAATAGCTGATAAGAGGCTT +TTGTTTGAACTAACAGACGGAACGACTCCGGTTTAGTTCAAAAAATTCTA +AAAACACGTTGTGTCAGGCTGTCTCATTGCGGTTTGATCTACGAAAAATG +CGGGAATATTTTTCCAGAAAAATTGTGACGTCAGCACGCTCTTAACCATG +CGAAACGAGATGAGATGTCTGCGTCTCTTTTCCCGCATTTTTCGAAGATC +AAAACGAATGGGACTTTCTGACTCCACGTGTAAAAAGGGGTTACGACGGA +CCCTGGCCTAGAAATTAGGCGTGAAAATTCTCGGGCACTGGATGTAGTGA +ACGCCCGCGATGAAAAATTGGGGGAAAATTAGGCTTTCTTTGCGAGAAAG +ATTAATTAAAAATGTTTTCCTTTGTCGAAAATAATTTTTAAAAAACACAC +CACGTGTATTCAGCTCGACCAACGCCTCGAAAATTTTCAAAAAAGGCGGG +AAAAATTAGTTGAATTCGCCAAGAGGAATTTCACCGCAGCGCGTGCAAAA +ATTTCAGCATTTGCGCGTGACGGTGTTTGCACAAATTACACCGAATGGTC +GAGCTGAAAACACGTGCACACTTTTAAATAAAACTAGAAAATAAATCCCA +GGCCTGCAAATATTGCACACAAAACCGTAATCCCCTTCGCGCTAAACAAC +ACGCGCAACGATGCTCCGCTTGGGGACAAGGAAAAATTAATTTAACTCGG +GATTTTCATTAAAAAATTAGGTTTTTAGTTAATTTTTCGATGTTTTCACT +GCGAAAAAGTGTTAAAATAACGATTTTTCAACCTATTTTCAATTAATCCG +TGCAAAAAATCGTGTATTTCTCGAGTTTTGAAAGAAATTTATGAAAATCG +GCATTTTTAATAATGGTTTTTCAAATAAAAATATAATTTTTCGGTGCAGA +AAAGTCGTTGCTCGTACAGTTTTTTTAAAGCATTTTCACATCAAAATCCT +CCATTTTTCCAGTAAATCGATATGGAGTGCGACGAGACAAAGCTGAGCGA +CGGCGCAAGCGGCTGGGTGCCGAGTATCCCGACAGATATCGATTCAAAAG +ACACACCGTTGCTCGATATATCTTCTCAGGCGATTTGGGCGCTTTCCAGT +TGTAAAAGCGGTAAATTTTCCGACTTTCAAGGGAGAAAAGTGTAGAAAAA +TCGAAATTACTTCTTAAAAATCTCGTAAAAATCGAATTCTTTCAGGATTC +GGCATCGACGAGCTCCTATCCGACAGTGTTGAGAAATATTGGCAAAGCGA +TGGCCCGCAGCCGCACACGATTCTTCTAGAATTCCAGAAAAAGACCGACG +TGGCTATGATGATGTTCTATTTGGATTTTAAAAACGACGAGTCTTATACA +CCGTCAAAGTTAGCATTTTTGGCTTTTTCAAACGAAAAAATACAATGAAA +CACTGAATATCTAGTTTTTTTCTCAATTTTTGCCTAAAAAACGGCGATTT +TTCACTAGCTTTTCAATTAAAATTTGAACAAAAAGTTTTTTAAAGGAAAA +ACATGAATTTCTAGCTTTTTCAGAGGTTTTCTATTAAAAAATAGAGATTT +TTGTGATATCTGACTGAAAAATTACCAAACTGTCGATTTTTTTAAACTAT +TTTTCACTTAAAATCTGCAATTTTTTTTTTCGAGGAAACATGTGAATTTC +AAGCTTTTTCAGAGATTTTCTATGAAAAAGGTTCGTGCCGAGACCCATGT +GCTTTTAAACTTCAGAATTTTCCCAATTTTGAAATTAAAAAGAGAATGAA +AATTGATTTTCATGGAAAAATGCGTTTTTGGCCCAAAACCTCCAAAAAGT +ACAAATATAGGTCGACTTTCAACTGTTTTAGATCAATTTTTTTGCAGAAT +TCAAGTAAAAATGGGTTCATCTCACCAGGATATATTTTTCCGTCAAACAC +AAACATTCAACGAGCCCCAGGGATGGACATTTATCGATTTACGCGACAAA +AATGGGAAACCGAATCGCGTTTTTTGGCTTCAAGTACAAGTTATTCAGAA +TCATCAAAATGGGAGAGATACTCATATAAGGTAGAGGAATTGAGAATTTC +AGAACGAAAATTGCCGAAAAAATGAAATTTTAGCGAATTTGAGTCGGAAA +TTTCGAAATTTGATTGATTTTAAGCAAATTTCCAACTAAAATCTTGAAAA +TTTGATCTTTTTAGATAAATTTTTTTTTAATTTTGTGCTTTTCAAAAAAC +CTCAAAAAACAATTAAAAATTGAAGTAAAATTAATTTTTCAACAATTTTT +GAAAGGCCGAATTTTTGATTGAAAATTTTCACAATTTGTCCATTTTGTGG +TGGGGCTTATTCCGAAAAATCGTTGTTTTTTTTTTCAAAAAAGTTATAAA +AACTTTAAAATTGCCATGTAAAATATGTTTATTCTCAGACCTCGTAGGCA +CGAAGCAGGCGTAGGTCGCCTCGCAATAAATTTGAAAATCTCAAGAAAAA +TCAATAAATTTGTGATTAATCAAAAAAATTTAATTTCCTGGTCCCAGCAC +GAATGCTATTTTTCGAAAAAAAAAAAGAGGCGAGCCTAATATAGACCACG +CCCACAAAATGGGCAAAAGTTTGATTTTTCAAAAAATCGAAACAAAAATT +TTTCCAATTTTGTGAGATTTTAAAATTTCCGGTTTTTGGAAAATCGAAAA +AAAATTTCTCGTTTTTTAATTTTCAAAAAAAATTGTGCCTAAAATTCAAA +AAAAAAATCAATACTTTCTCAAAATTTCCAGAAAACAGTCCATTTTCCAG +GCACGTTCGAGTCCTTGGACCCCAGCGATCTCGTGTCTCCACAACGAATC +GAATATTCACCGGAGAACCACACGGACCGATTCCCGATAAAAATATCACT +AATTTCGACGACGAGGATTTTGCCAATTTTATCGATCACTCACTTGTTCA +CTTATCACTTCGTTAAATTTACCTCCAGTGATTCCAGATAATGAGCCAGT +TTTGCATTGAAATTTAGTGCCAAAATATAGAAAATCGCATGATTTAACAT +AAAATAGCGTTTCGAATTGAAACAATGGAAAAAAAGTGCTATGATGATTT +TTTAACACTTTTAATTGTTCCAATTTGAAGTAAAATCTATTTTCAGATAA +ATCAACTGATTTTCTATATTCTGCCACTAAAGCTTAAAAACTTGCCCTGC +TGTCCTAACCTTCAAATTGTTCCCTGCAAATTTTATTATTCTTGTTTCAT +ATTTTTGCGATTGCTTCGCGAGACCCAAACTCACACATTTACCTGTAAAA +TATAATCGAATAATTATTTATATATTTTCTGTAAATTTCCTTAGTATACT +ATAAATTTTCTGATCTCTCTTCAAAAATCGCTAGAAAAAATAAACAAATG +TCGGTTTAAAAATTCCTGGTAATTTACCTTCTATAGAAAATTTTTCGAAA +AAAAAACCGAAGAAATTCAGATGGAAATTCCCGATCCCGAACTGCCGGGA +ATACCGATTGATCCGCAAGATTTGGAGATTCTAGACACGCCCACACGGTT +TTACGAGAAGCTTTTAGTGCGTTTTTCGTGTCGGGACCCGGAAATTTGAC +ATTTTTGGCGCGCGGCTTGTTAGACTCCAAACCTTTTCAAAGATTTTTTT +TTCGAATTAAATAACATTCGTGCTTGGGCCCGGAAATTGAATTTTTGATT +TGAAAACAATTTTTTTTGAGTCCAAAATTTTCAAAGTTTGTCCATTTTTG +GCGCGTGGCCTAGTAGGATCCGCCCCTTCTAAATTTTTTTTGAGCAAGTT +TTCTGAAGCATTGATTTCAAAAATTTTTTTTGGAAATTTCTGGTTTATTT +TTCCGGTTTTTTTCCGAGTTGCTGTTTAAGTTTGGAGAAATTCCAGAATT +TGTCAATTTTTGGGGCGTGGCTTTTTCAGTAAGCACAGTTTTTTTTTTTT +GAAAAATTGAAATTTTCGCGGTGCGGTTCAAGAAAAACCACAAAAACTCA +ATGATTTTTTAACGAAAATTTCAAATTTCTTGCAAGACCTACTGCAATTT +CGATTTTTAGAAACTTTTTGAAAAAAATCCGAATTTTCTGATTTAGCCCC +GCCCCAAAAATGGAAAGATTTCCGAAAATTCGAACCAAAAGTTCGCAAAA +ACTTGAATTTCTCTCACACAGATTGACGCGCTAATTTGAATTTTTCCAAA +AATAAGCCCCGCCCCAAAAATGGACAAATTTTAAAAATTTTGAACCAAAT +AAATTCAATTTTTTTTCGCTTTTTTCCGTTTTCGAACAAAAAATTCTAAA +AATATATGGTTCTAGGCGGGGCTCAGGCACCCATCTACCTACTTAAAAAT +GCGTTAAATTTCAGGAATTAACTGCATCAACCGAACGGCGTCTCGCATTG +TGTAGTCTGTATTTGGGCGAAGGAGATCTCGAAAAAAATCTGATCGCTGC +GATCCGAGAAAGATCCGAAAAATCCGAGATTGAAGTGACGATTCTGTTGG +ATTTTTTGCGCGGAACACGGACCAATTCAAGCGGCGAAAGTAGTGTAACA +GTGCTGAAACCTATTTCGGAAAAGTCAAAAGTTGGTTTTTTTTGCAAAAA +AAAATCGATAAATCGATAAAAACCGACAATTTTGAGAATTTTCATTTCAA +ATTTGAGTCCCACATGCGCCTTTAAATATGGTGTACTGTAGTTTTAGCTC +GAATGTTGAATTTCAAAAATTGAGAATAAAGAAATGTCGTGACGAGACCC +ACAAATGTTTTGAAAAAAATTTTCAATTTCAAAAAAATGTAAAAAATTGG +GAATTTCCCTCCAAAAGTTAAATTGGTTTAGTCACAAACTTTGAAATTTT +GAAATAAAATTTTTTTCGGCTAAAAATAAGTATTTTTTAAAAACTATTTT +GAAGAAAAAAAGTTAGGTCTCGCCACGATGTATCTTGTATATGTGTATCT +AAATTGCCATGTCGTGACGAGACCCTCTCATATTTTACACTGCAACTTTT +TCCTCACGAGGGACGAGGAAAAGTGGTTTCTAGGCCATGGCCGAGGGGCC +GACAAGTTTCATCGGCCATTTATCTTGCTTTGTTTTCCGCCTGTTTTCTT +TCGTTTTTCACAGCTTTTTCCCATTTTTTCTTATTAAAACTGATAAATAA +ATATTTTTGCAGATGCCAAAACGATTTTCAAGTAAAAAAATCATGTATTC +AGTGGGCAAGCAGCGGTGAAAGTGGGCATTGTAATATGATGGATTACGGG +AATACAAAACCTAAACTTTTTCTGAAACATGATACATATGATGCTTAAAT +GCTGAGACTACCTGATTTTCATAACGAGACCGCTGAAAAAGTTTTGAGGT +TTTCAAAATTCAACTTTTTGTGCGAAAATCTCGACTTTTTCACCGAAAAA +GTTGAATTTTGGAAACCTCAAAACTTTTTCAGCGGTCTTGATATGAAAAT +CAGGTAGCTTCAGCATCTAAGCAGCATATGTATCATGTTAAAGAAAAAGT +TTAGGTTTTGTATTCCTGTAATCCATCATATTACATTGCCCACTTTCACC +GCTGCTTGCCCACTGAATACATAATTTTTTCACTTGGAAATTGTTTTAGC +ATCTGCAAAAAATATTTATTTATCAGTTTTATTAAGAAAAAACGAAAAAA +ATCAGTGAAAAACGAAAGAAGACAGGCGGAAAACAATACAAGATAAATGG +CCGCTGAAACTTATCGGCCCCTCGGCCATGGCCTAGAAATCACTTTTCCT +CGTCCCTCGTGAGGAAAAAGTTGCAGTGATTTTGCTCAAATAAAAAAATC +CCCCAAAAACCGATAATTTCACCATTTATCAGATATATCTCTTCCACACA +CCGGAGCTTAGTGGCTTAGTAAAACGAGTTCTTCCACAGCGAGCCGACGA +GATTATCGGTCTCCAGCACATGAAATTATACATTTTTGATGACAATGTAT +TGATTAGTGGGTTAGTTTTTTGTTTGCATGGGTCAGACTACAAACTACAA +AAAGCCTAATTTCAGAGCAAATTTGTCGGATTCTTATTTTACTAATCGAA +CGGATCGATATTTTCTATTCAGAAATTGCAAACCATTGGCAGATTTCTTC +CACGAAATTATCAATGTTGTTGGTGAGTTGGCGATTGCGCTCCACCGCAC +ACACTGTTCAATGGGGCTCGCTTGAACTGATAATTTTTTCTAAAAAATTA +CAAAAATTGTTTTAATTTGCCTTCAAAAAACCATCAGTTAATTAAAATTT +TCTAAGCAAAAAATTATATACTTTCTAAAAAAATTGAATTTCCCGCGAAA +ATAATTTTTTCTGAGAAAATTTGAATTTTTCACCAAAATATTTTTTTCAA +CATTTTTTACCACAAAATGAGGCGGGGCCTCGGTATACACGCTCAAAAAA +TCAAAAAATACTTGTAAATTTGACTACCAGCTATTTTTTTTTCGAAAAAA +AAATCGAAAAGTAGGCCAGTTTTCGAAAAATTCTCGACAAAAATTCCGAA +AAATGGGGCGGAGACCTGTGCGGTATTCGGCATTCGGCATATGCCGATGC +CGGTTTTTGGAGCCCGTCATATGCCGTTATGCCGATTTGAAAATTCACGG +CATATGCCGAAAATGCCGTTATGCCGAAAAATCCCGAATGCCGCACAAGT +CTGGGCGGGACTTCAAAAACCACGCCCACAACAGAGAACAAAAATTTGGA +GTGATGGTTTGCAATTCCCTCGCGCACTTTTTCTTGTTTTTTTTCAAAAA +GATGAAAAAGCGCTCTACTGTACACGTTTTTTTTCGAATATTTTCATTAA +AAATCCAATTTTCAGCCGACTCGAGCTTCATTGTCGAAAATGAGCAACTG +GTGCCGAGCCCAAAATGTGATGTGCACCCATATTTAGGTAATCTGAAAGG +ATGGGTAACCTGAAATTTTTCCAAAAAAATTTTTTTTAAGGCTCCGCTCA +TCTCTACCGAGAAATGCTCAAAACACGTGTGAATCGAGTTATCGAAAAAT +ACAAAGAATCGCGAAAAACGTCGTCGAATTGCATGTCTGCTGACACGTGG +ATTTACCCCGTTTTACAAATGGGGCTTTTGGGAATTCATCAGGAGTTTGA +ATTTTTGCAAAAACTTTTCTCACTGAAAAATCCGGAGCTCAAAATGACGA +TGGCTTCGGGATATTTCAATTTTATTCGAGATTATGAGGAATCGATTCTG +AAAGAAGGAGATTATCATTTGGATATTCTTACAGCTTCTCCTTTTGTAAG +ATTTTTTTTGAGGGAAAAATATCTGAAATAAGTTCAAAAATTTCAAAATT +GAATTTTTTCGAAATTTTTGTAGGAAATTTTGGTTAAAAAAAGTTTTCTC +GAGAAATTTGAATTTCCCGCCAAATTTTTTCTGTGAAAATTTGATTTTCC +CCTCAAACATGTTTTCTCATAAAATTTGAATTTCCCGTCAAAATGTTTCT +GAGGAAGTTTGATTTTCTCATCAAAATTTTTCAAAATTTCCAGGCGAACG +GATTCTTCGAATCAAATGGCTTCTCGAAATATATTCCACCACTATATTCC +AACATTTCTGATCAATTTCTTCGAAAACGAGAAATCAACGGCCGATTGAA +TGTAAAAATGTTCGAATATCGAAGAGAAGAATGGACATTTCATGCAAAAG +GTCTTTGGGCAGAACATAATAATCAATTAATGACATTAATTGGCTCATCA +AATTACGGTTATCGATCGGTTCATCGAGATCTTGAAGCTCAAGTGATGGT +TGTTACAAGAAATCCGACACTTATCGATCGATTGAAAGATGAGAAAAATC +TATTATTCGAATATTCATCGATACTTGACATGGCTGCACTTCAACAACCG +GAACATCATATTCCACCATTAGTTCGAGTTATTTCACGTCTTATTCGGAG +TTTTTTGTAGACGTTTTCCAATTTTTTATAGCGGAATAATAAGGTTTTTG +ACTTTAATAAATCTTTGTAGATTTCAGTTTTTTTGAAATGCAACATTTTG +CCGAATTAGGCCATTTGACAATTTTTGGTCGTGTCACGGCGCGGTTTGCA +GTAGAAAACTAAATGTATTTTGATTTGTTTTTTCGAAATATCCGAAAAAC +AACAAAAAAATCTGTTTTTTGTTGAAAAAAATGTTGCGAATTTCAGAAAA +CGGCACTTTTCCGATTTCTGCCCCCTAGGGCTGTTATGAGGGACGTCCCC +TATTGGGGGGCGGGGACGATCATTTGTCCCCCCATGGGGGACGGGGGCTC +GTCCCCGTCCCCACGTCGGGGGACGGGGAGCGCCCCTTGTCCCCGATGGA +ACGAAAAGTCGTCCCCTTTTAATTTTTGATTTATTTTAGATTTTCACTTC +ATTTATTACCGGTACAGAGAGTGTAGATAGTTAGAGAGTGCCAGACATCC +GGGACCCAATGGAGCGGGGCGCGCGGAAGAGACGATTAGTGTCGATTTAC +GAAATTTTCCTCGTTGTCATCATTTCGTAAATCGACACAAATCGTCTCTT +CCGCTTGGGTCCCGGATGTCTGGCACTCTAACTATCTACACTCTCTGTAC +CGATAATAAAATATTTTTACGTGAATCTCGTTTCCACTAAGATGTGCGGG +TGGATACCGTGGATATTCCACACAAAAAACGTGTCGCTTTAATAATTATG +AAGCAAAATACAAACGCACATTCTTCACATTGGGTAAAGGGGGCGCGCTC +CCCCTTTACCCGGGCGCCCCTTTTCGGGGGGGGGGGGGGGGCGTATTACG +GGAGGTTTTTTGAAAAATAATTTTTGAAATTTGTCAACTGTCGACAGCTG +TCGTTCAATTAATGTTTTTTTTTCAAATCTCCATACAAAAATGTTCATAG +TAAATTCTTTATCAATATTGGGGTCCCTCACAAAGTTCAAGTTTTCTTCT +CACTCTTCACGGCCGCCTTCGATTTTTTCTTAAGACCTTCATTTGCATCA +AAATACATTCGACAAATTTGAGTCACATAAGCATCATCATGTGCGTTTGC +CTGCAAATGTTAACAAAGTACCAGGCGGATGCCAAGCTTTCACGTCTTCA +TGTCTACGTAGAAAATGCAGTCATGAAGTAGGCACGCAGACAGACAGGCA +AGTACATAATCAGGCAATAAATGGGCAAGTAGGCAAAGCAGGCATGAAAT +AGGCGCTTAGGCACGTGGGTAGGCAGGTATGAGACATAGGCAAACATGCA +GGCAGGTATGAAAAGCGAGAAAAGGCAGGTGAGCATGATGAAGGCACATA +GGCAGGTAGGCAAGGAAGCTCCTAGACAGGTACAAAATAGATGTGCGCAA +AGTAGGCATGTGCAAAGAAACTAAGCTCGTCGCCAGGCATGAGGTAAGCG +CATAGGCTTGCAAGTAGGCGAGTAAACACGCGGGCATCGAATAGGCAATT +AGGCAGGTATTTTTGTGCTCCATTTGGAAACACACTTACTGGATAGAAAA +GAGTGAGAGTCGTGTAAAATGCAAATGCCAAATAAATTGGATCCGGTGCA +GCACATTTTCTCTTTGATCTCGTTTGTTCAATCAGACTCCGATAATTGAT +TTCTCCAGTTTCACTTGTATTGATCGCTTGGAAGAGGCTCTCGATGACTG +AAAAATGCTCAGAAATTTCGGATATGTTCTCGATTTTCAGTGAATTTTTC +CTGAGAAAAAGCTAAAAACTCACGAACAAACGCTGCCGATCGTCCACCAC +CAGTATTGCATACGACAAAAACCGGTCTCTCGCTGTCTGTCACTAGTTTC +AACAAATACCTAATCTCCTCGGCATCTTTCGGTCCCATATGCTCCGGCCA +TCCGGTATACTGGTAATGAGTCACCTCTTGAGTACGCTTCTTTCTGGAAA +AAAGTTTGTTGCAGGCTACCTTTTATGCCTGCATGGAAAAAAATAGTAGG +CGGACAGGCGTGAGGAAGGTTAGAATATTGATGAGAAAAATTGAAAACAA +TCATTTCAAAAAGCAAAGAATTGACCGGTTATTATTAAAAAATAAAAATT +TTTATCCGGACAATCCGATGCAGATGTGAGTGCCTGCCTACCGGCGTGCC +ACCGCGCCTATTTCATGCCTGCGTGCCTATACTTACCCAAATGTTAGCAA +CAATTGTCTAGTCTTCAACAAAGGCTTCGAGATACTCTTCGTGCAAGTGA +TTGTTAAGTCCGCCAAAATTAGTTTTTCGTCGAGTTCAGTGGGAAAGTAC +CTATCACAGTTCACCTTATTAGCTCCAATAAAGTGATCTGAAAAATAAAT +GGATTAAAAACGGAGGGTGGCTTGATAGACAGGCAGGCAGGACTACTGCC +CTGTGTAGGCCGTCTTGTAGACAAGCAGACAGGAGTGGGTCACCATGTAG +GCAGACGGGAGGGTGTAGGTTGTCTAGTGGGCAGGCAGGCGTAGGCTGCT +GCCAAGCAGATATAGGCTCACCTATTTCCGCGAAATCGCACAACATCACA +ATTGTGCTTGGTTTATTCAGCTTCACTGACTCCCAAAATGCGGCAATCGC +CAAAATATCGGAGCTTTTCTTATCAACAGGCAACTGCGGAGCAGGCATCA +ACACAAACTTCAAGCCGTTATCCAATTCAACAACATGTGATGATTCTCCC +TGGCTGAAAATGAAGATTTTTTGGTAGGTACCCATAATTTTGCCTACCTG +TCTACCTATGTGCGCTTGAGTTAAAGGTTAAACCTAAGCCTATGCCTAAA +CCTGAGCCTAAGCTGAAGCCTAAGCTTAAGGTTAAGTGTAAGCGTAAGCG +TAAACCTAAGCAATATGTAGAGGCGAAAGGTAGGCAGGCAGGCGTAACAG +TCTTACCCATTCTTTTTCGAAGACTCATATGACACCGGATCACATTGACA +GTGATTACCTCCCTGTAAGCCGCAAAACTGGGCAAAATCGTCTCCCGTAA +TTTCTAGGTTATTTGGAACATTCTCAAATACTGAAGTACAATTTCTTTTT +CTAGTAACGAAATCCGAAATTTGCGTGTTGAATGTCTTGAGGAAGTTTGA +AAAACGTGTCTCATTCACATCCACACGACTGATCATCTGATTTGGCGGGT +ACAGTTTCTCTTTTTCTTCCGAGTCGAGTATTTTGTAGCCGTTCGGGGTT +AAGCAAAAGTAAGCAATTATTGCACAAATTATGACAATGACGATCAGAGC +CAAAATTACATATTGTCCGTGTGTTCTGGGATTTTGGAAATTTTTAGTGA +AGCTTCTAGGCTTTAGCTTATGCTTAGGCATAGGCTTAGGCTTCGGCTTA +GGATTAGGCCTAAACACAGGAGCATATAGGTTGGCAGGCAGGCAAAATTA +GAGGTACCCGCCAAATATCTAGAAGCTTCACTAAAAAAAAAACGTTTTGA +ATTTAGCATGAAAACAATTTTGAAAAAGTAAAATGTTTTCTTATCTCAAT +TTTTTCCTTGATTTTATATTGTAATTAAAAATAATAATTTGAATTTTCAG +CTCGATTTAGATAGAGTTGTGCTAGATTTCAAGAAGAAATTGAGAATTTT +CGTAAAAAATATTTTTAACGCGAAAAAATTTTTAAAGCTTTAATCCAAAT +TGTTCAAAAAAGTTTGGAGTAAAAAATTTGGAATTTTTTTGATTTTCACC +CGAAAACCTTTCTTTAGAATGTCTGCCTCTTGCCTCCATCCGCGCCTTAT +GCTCAATCCGCGCCTTATGATTTTTCTCCGGGAACTTGAGACGATTTGGT +TGTTGGGAGAAGAAGTGCGGAATGTGGAGCGTTTGTTGAGAAAAGATAAA +ATTTGGAATTTTTTTGATTTTCACCCGAAAACCTTTCTTTAGAATGTCTG +CCTCTTGCCTCAATCCGCCTTATGATTTTTCTCCGGGAACTTGAGACGAT +TTGGTTGTTGGGAGAAGAAGTGCGGAATGTGGAGCGTTTGTTGAGAAAAG +ATAGATTTTCTACTATTTCTCAATTATTCAATACTATCGAACGACTTGAT +GTCCAGTCTTTGAATGTTCTTGTCGAGGAGGCGAAGGTTATTGGTAAGTG +TATGCGTGGCTTTCCGATGAATTACCAACGGCACGGAAAGCCTGAGTGTA +CCCTTTCGATTTCATCTTCGGAAAGTGTGCTAAGCGTAGGCGCGTTAAGC +TAATTTTTCCTGGTAAATCCGCAATTCTTGAAGATCGAACCAATAGGGAA +CACTGTGGCACCACGTGCAACTTCAGGGGTAGGCGGCAAACACAACGGAA +ATTTATCGATTTGCCCAATTTGCCAGAAATTTCGGTTTCCGAAATTTTGT +CGATGCATTAAGGGTTTGATAATAAAATCGAGTTTGGGAATTAGCGTTTT +TCAAAAATTGTCGAATACCTTCAGAATTTTGGTTTCCGAAAGTTTGTCTA +AAAATGCAGGGGTAGGCGGCAACTGCCGTTTGGCATATTTATTTTTGGCG +AATTCACCAAATTCCCGTGAAACATGCGTGAACTTTCTTCTCGTTTCTTA +ATTAGTTTTTCATCAAATTGATAAAAATGAGAAAATTATAAATTTGTAAA +TTCACTTCAAAATGCAGGCGGGCAGGTTTCAGTCAAGCCCTGAAACCGCG +CCTGTCTACCATGGAAGCCCTACTTTCAAATAAGATCAACTCACTGTGGT +GGTGGACCATTCTTTTCAGAATTTCCAAGATCTGGCGGTGGGAGAATTGC +AGTCGGCAGAGGCTTGAATAAATTTGAAAAAAACAAGTCAAGAGCAGCAA +GAGCCTTTTTCGGTTCATCAAGTCTGTTTTGAAAACTTGAAAACTCCAGT +CCACCATCATCCAAGCTCTTCAGAGCATCCTGAACTTCACCGAGCGACTT +CTTATTGCCAACATCCTTCACAAGTTCTACCAGTTTTTCCAACGATTTTT +CCAAGCCCATAAGACCACCAAGATTAGCCCAATCAACCTTCTTAGCTTCC +GTGAAAACATAACCATAGTCTACAAATTTTGTGGAATCAGACTTTTTAAT +TCCACTCTTCCATGCATCTAGCTGAACAAACATCACATCCAAAGATGCTC +CAAGCGCCACCAGCTTCTCCAGATTATCCTTATCGTCCTGTGCCAAAGTG +GCTCCACTCGCTGCCAACTCTCGTTGCACAATTTGTGCATGGTTCTTGAT +AATATCCACATTTGCTCTTTCTCGGAGCACGTCCTCCAGTCGAGCAATTT +CTTGTGCCGCTGGGCCAATGGAATTAGTGTGTTCAGCGGCGTTTGGAAAC +TGGGATGTTTTATCCGAAGCAAATTTGCGGCGCTTGCTAAAGTACAGCGC +CAGAGATTTCAGACCACTATTGAGGCTTGAAACTGAGATCAGAGCATCTT +CGACGGCAGTGACTATCGGCGGGAATTTTTGATCTGCTCGGAACGAATTC +AAATCTGACAGGTTCTTTTGAATTTTGTCCAATTCTTTGTTGGATTGAAG +ACAGCTCAGTACGTCGAGAAATTGAGCAATATCAGATCGAGAGTCATTGA +TTTTTTCAATAGCACGTTTTTCTAGTGTTTTCAAAAGATTCGGATTCAAG +AAAGTAGCGTTTGCCGTCATTCTACTCATGGTCAGCGACAAGCCGGTCAT +TTTTTTCACTCCATTAAAGCATGGCTCAGCGGTTGTCCAATTGCTATTGT +TCATATCCTTGCAAACAGTGAGCACTTCTGCGTGTCCTGATTTGCTTTCA +ACAAGTTGATTCATCACACTTTTCAATATCGATTTCGATTGTTCCAATTC +GGTGTCAATGTTCGATGCAATTTTAGATAGTTCCTCCAGATTCGTGAAGT +CGGGGGCGGTAGTTAGAGTAGATTTGGCGCATTGGGCTGAAAGTTTATTT +TTATTTTCGTTTTTTTGAGTTTGAACTTTTGTGGACAACCGACAGATTGG +CTCAAACTAAAAGGACTCTAAAATATACAAATTTTGGAACTCAAATCAAT +TTCGCAAATATTACTTTTTTCTACGGAGCTTTGATCAGGGTGGGGTGGCA +AACGATTTTTTTCCAGCAAACGGTAAATCGGCAAACCGGCATTTTGCCGA +TTTTCCAAAATGGCCGAAAATTTTTGAATCCCTCCCTCTAAACACTTCCG +GCAAATTGTTATCCAGCAAACTACAATTCGGCAAATTGCCTGAATTAAAA +ATTTCCGCCCAATCGGCAAATTGCAGTAACTGCAAATTTCCGATAAATTT +GGAGAAACCGGCAAATCGCCGAAAATTTTTGGTAACTGGAAAAAATTTCA +AAAGGCACTGTACCCGTGCTTCCGTTTTTTAAAAAATGCTTCTAAACAGT +TCCGGCATATTGATATCCGGCAAACGGCAAATCAGCAGTTTGGCTAAAAT +AAAAATATCCGGCGAATCAGCAAATTGCTGGAATTAAAAAGTTCCTCCAA +ATCGGCAAAACCGGGAATTTGGTGAATTCGCCAAAAATAAATATGCCAAA +CGGCAGTTGCCGCCTACCCCTGCATTTTTAGACAAACTTTCGGAAACCAA +AATTCTGAAGGTATTCGACAATTTTTGAAAAACGCTAATTCCCAAACTCG +ATTTTATTATCAAACACTTAATGCATCGACAAAATTTCGGAAACCGAAAT +TTCTGGCAAATTGGGCAAATCGATAAATTTCCGTTGTGTTTGCCGCCTAC +CCCTGAAGTTGCACGTGGTGCCACAGTGTTCCCTATTGGTTCGATCTTCA +AGAATTGCGGATTTACCAGGAAAAATTAGCTTAACGCGCCTACGCTTAGC +ACACTTTCCGAAGATGAAATCGAAAGGGTACACTCAGGCTTTCCGTGCCG +TTGGTAATTCATCGGAAAGCCACGCATACACTTACCAATAACCTTCGCCT +CATCGACAAGAACATTCAAAGACTGGATATCAAGTCGTTCGATAGTATTG +AATAATTGAGAAATAGTAGAAAATCTATCTTTTCTCAACAAACGCTCCAC +ATTCCGCACTTCTTCTCCCAACAACCAAATCGTCTCAAGTTCCCGGAGAA +AAATCATGTGATCAGTAGTTTCTCGGGCCCAAGCGTCGGTTGCCAATTGA +GAGTTTAGTGCTCCAATATCAATTGCTCCATTCGGTAGACCAACTGTGTA +CTTCTTGGTTCGCAGGGACTGCCCGATGGATTCGATGGTTTGAAGATGGA +TCTTCGATTCTTGATTTGGAAATGCATTCCGGATAGATGCCATGTGTTCT +TCTAGCTTTCTTAGTCCCCGATTGATGTCTACAATCTTGAAGGATGAAAT +AAAGTTCATCACATCACGAACTTTTGGCCATAATACAAAGAAAGAAGCAG +CAGAATTATTGTTTTTGAAGCCATGCAACGTAATCTTCGGATTCTCCACT +ATGTTCAAAAAATCTTGGGATTTTTTCAACAAATCGTTTAACGCAGAATG +GGATTTGGGAATATCGGTGAAACTAGTGAACGCTTCAATCTCTGTGTACG +AGTTGCTCCATACTGATAGCTTTTCGGAAAGGGTTGTAACTGATGAAAAA +CTGTCTGTAATGTCTTTCATGTCTGCCTTGAAATTAGTCTCGTCTGGCCA +CTTCTTGAGATCTCCAATATCATGAGCCACGTGGACAACACTTTTGACAG +TTGTGAAGAATTGATCTGCCTCAACATCGTCGCCGATATTCGATTGTAGT +TCTATAAAGGTATAGTTTTTGGGGGCAAAAAACGAAAGTGGTTCAAAATT +TTGGAACAAAATGCCTATTTTTAGATAGCTAAAATCTAAAATTTTGCAAT +GCTGACAAGTTGTGAAAATTTGAAATTTTAACAGAAAATAGGCTTTTTCC +TAAACTTTGAATCACCTTACTTTTTTTTTGAAATTTTCGAAACTTTTCGG +TTATTTCCAAAAAAAAGCCGCAAATACTCTATCAGGGGTAGGCGGGAATT +GCAGTTCGGCAAATGTATTTTCTGCAAATTCGGCAAATCGGGATGTGTAC +AATTTTGTCGTCTCTGGCAGTTTACCGACTTGCCCATTTACCGAAAATTT +TAATTCCGGCAAATTGTCCATACTCTATTACTACCATAGGCCCTTATATA +ATCTTTTTCCGCCCACCCCTGTACTCTATTACCACCTAATCTGTTACTAC +AGTGGATTTTTTGAAACCAAAATTTCAGCTTTTGAATTTTATATTCGTAG +TGAAAAGATATTCGTAGTGAAAAGTTGAAACCTGGAAAACATAGTTGCAT +AATTGCATCGTAATATGTAAAAATAGGTCTTCCATGGTAGATAGGCGCGG +TTTCAGGGCCTGCCTGGAACCTGCCTGCCCTATGTGAACGAGTAGACTGT +AGTTTTAAAAAACAAAAAAAGGTATTTGCCTAACAAAAAACATACTCAAA +TATTTGAATGTTTGCAACCAAACCTTTAAGCGCTATCAGTTTAGATTCCA +GCGAACTGTAGTCAATTGCATTCAGTTGATCCATTGAGAAATCGTATTTG +AACAAATCCAAAGTTAAATTCATTGATGGAATGGTTCCTTTTGTCAATTC +TTGTTGTAGGTACATTGCATTGATCAATCGTGAGGCGAATTGTAATCGCT +CAACGGCAGTTATCAAGTTGTCATCTGCAACTTTTATGAATGATTTTTTT +AAAAAGTTATTTGTTGTCATTTTTCTTTTATTAATTATTACGTATATTAT +ACGTATCATGCGAGTTTAGCTTTCCAACCCCCCGCGAACTCTTTTTACTT +TTTTTTTTTTTAACTTTTGTCTTTTTTGTCCTTTCTTGGCTATTTTTTTT +ATGAGAATTGACCCGAATTTGACTTTTTTCGGATTTTTAGGAATTTCTAG +GAATTTTTCTTTTTTGTCAAAGCGAGCTAACGCTCGCCACTGACGCCAAG +CCTAACATAAGACTTAACCTAAGTCTTAGCCTAAGCCTTACAAGGAAAGT +CTTTGAAGGGGCCTGTAGATTTGGGTTTCTCATGTTGATATTCCGATAGA +AGAGTGTTAGTTTTGATCTCTCCAAAAAATTTAGCTGCCCAAGCCAAGTT +TCAGCAAAGTAATGACATTTTGAAATTTCAGTTAAAAACACCATTGAAAT +ACACTGTCTTACAGTGCTATCCACACAAATATCAGCTTGCGTGAACACCG +AAAATGTGACGCCCACCACAATAGGCTGAAGACAGTGGATTTCAATGGTG +TTTTTAACTGAAATTTCAAAATGTCATAACTTTGCTGAAACTTGACTTGG +GCAGCTAAATTGTTTGGAGAGATCAAAACTAACACTCTTCTATCGGAATA +TCAACATGAGAACCCCAAATCTACGGGCCGCTTTAAAGACTTCCCTTGTT +AGCCTAAGCCTATGCAAGACACGCAAAATATACATTAACATATATATACA +ACAAATACAACGTAAAAATTGTTTTTCTGTAATTCGACTGACAAACCTTT +AGCTTCACGTTTGGAACGTGGATCTAATGACATCACATTAAAGAAACTGG +ATTCTTCTGGAACAAAATATATTGAAATTAAAGCTCTGAAACAGTCAAGA +AACCTTCGAAAGTATCCGAATTGACAACACGATTAACCGTTATAATTATC +AAAACGATTATTATTTTGATTCCTGGAAGACAGAAGAAATTCGGAACGAA +AATAAAAATCAACCTACTCATTGCAAAGTATTATGAAACTTCCCTTTGAT +CGACGGTTTTTGAATCAATTAATGATTGGAAGTGTGAATTCTGAGAGAAG +GAGTGTTGGAATTTTTATTTATTTTATAACGAAAAGGTCACGGTTTCTGT +AATTTTAATTTCTATGAAAGTTTTAGGGACTCACAGAATGTCAAACACTA +GATGGCCGAAGAAAATTTGACATAAGCAGCGAAATTTGACCTTTCAAAAA +AAAATTAATATTACGTGAAATCTTTTTTTTTCCAATGGAATTGAATTTTT +GGCTGATACATGAGGGAATGTGTTTCAAGCTGTAATTTCAGTAAAACTGT +ACAAGAAAAAACGTTCAATATTTTTACCTTTGCTTATAACTCCTCTACAA +AATTTTTTCGGACAAAAAAATAAAACAAGCATGGAGATTACAGGTGAATT +TCGAATCCTCATCTTCATTTTTCAGACTGAAAATCCAAGAAAAGTAGCCC +GAACTTTTTTCTGAAAAAGTTCCTATATACTCATCAAACATTCATAAACA +GTATTTAAACAAAAAATCCCGAGATAACACTTTTGTCTTCAAGATATTCA +GGTTGAAAACTAATGTCCTGAAACTTGGATTTTGGGTCCTTAAGAAGATA +AAACAGATAATTAGCTTTTACGTTAATACCCGCAATCATTTGCAAATTAG +AGCAAAATTAAATTGAAACTTTTTTTTGGATTTAAACATTTTTTGGAGCC +GAAATACAAGTTTCAGGACACTAGTTTTCAACCTGAATATCTTGAAGACA +AAAGTGTTATCTTGGGATTTTTTGTTTAAATACTGTTTATGAATGTTTGA +TGAGTATTTAGGAACTTTTTCAGAAAAAAGTTCGGGCTACTTTTCTCGGA +ATTTCAGTCTGAAAATGTATGATTTTTTAATTCAAAATTTGAGGGAATGT +CGTTCATTGTGGCTCGAGGTCAATGGATAAATGGCTAAGACTAAAACATC +ATTGATCGAAGAATGATTTTTTATTCATAAAAACTATATATTTGACCTGA +AATCATTGTTTTTTGTCACTATAACCCATTGGAATGAGCTGTAGAAATTA +ATTAAATTTAGAAATGATTTTACCGATACGTGGCAATGTTTAATACATTA +GTTTTCTGGCCGAAGATTTGTATGTTTTCCCGAGAAAGTGAAGCGACAGC +TTAAAAGCGCATCGCCTTTAGTGAGAGGCAGGTCTCGACGCGACGACATC +TTTCCTCGCGCGCAGCGGCGAGATTTCGTCATTCTACGTGTTGGTAAAGA +AAAAGGACGTGATTTTATCGATTTGCATCGATTTTTTTTGGATTTTTCTT +TGTTTTTATTGTATTTTTATCGAATTTTTAGTAGTTTTAAGGTTTTTTAT +CGATTTTCCTTGATTCCGTTGCGTTTTTAAGCGTTTTTCTCGTTCGTAAT +GATAAAAAGGGGGTTATTTCTCCGTTTTCCAAGAGTTATCTGCGCGTATG +CCAGATTTTGCAGGAGGAATCATCAAAATTCTCAGTTTTTGGCATGTAAT +CCTTACGAAGAGTACTTTCTGAGGCTCAATGGCTTTTTCCCCCGCTGTTA +GGTGCTTCAGTAAGTGTTCTACTCCTTTCAGGGGTTCCTTCTCTCGTCTA +GGAGATTAAATATGTTCGCATTTGTTTCTTCCCTCTCTCTTACGCGCTCT +TTCCAGCATTGTTAGTTTATCCACGCTCTTTTCCTCTGTAATTTTTCGTT +TATCACTTTCTCTAATTTTTCGGTTTCCGGTTCGTGCACTCGCGCACCCT +CTCCCTATTTTACTCTATCTCTCACTATCTCTCACATCTATCTCTATCTC +TCACAAGCTATTTTGGTATTTTGCGCGTTAAGAAGTCATGTTTTGATGGA +CCGTGTCCAAAGGAAGAATATTTTCGTCGAGTGAAAGGTATGTAACTTCG +TGTGAAGTCGACTCCATGAGTCTTGTGAATATTCCGATAACGTTTTATCG +AGATGTATTATCGGGCGGCCCGAATTTTATGTATGTTTTTCATTGTGGTT +ACCATGTAACGGGAGTTCACATCGCAGAAAGAGCAATTCTTTATCGCGAA +AGTACGATTTCAGGCCCCGGAAGGCTTTCTTATCAGTTTAATGCGACATC +TTTCGTCGGGTGAGATATATTGTCTTGCGTTTCTATCGCATTTCATTGGA +CCGGTCGAGCCAGGTCTGAGTGTTTATGAGTACGAGTCGACTCCGTGAGT +CTCAATGATTTTCCGTTTTCAGGCGGTTTTCAAGGTTTCCCGTTCTTGGT +TTCTGCTTCATCTTCTACTACCGTTTTAAGTAGGATTGGCTCAAGTCTAC +GGAAGAGTAGAGCAAGCCTACGAAGAAGGTCTTCGAAAGAGTAGCGCAAG +TTTACGGAGGATTCACGCAGGTCTACGGAAGAGTGGAGCAGGTATACGTT +AGAGTGGCACTAGACCATACTGGGAGTCCGATTTCCAATTGGATTCTCGA +AAAACCTTGTACCTGCACAAATAACCAGACGAGCCGATATATCTACCTTA +CCGAGCTCCGGGTTAATCGTCGTCAAGTATTTCAGGATGAAGCGTATAAG +GCGATGATTTTCTTTAGCTATGCCGCGCGTTTTGCAATTGCATAGCTGTG +TATTCCGTGTAGACTTTATCGCTCACTTGTTCGATTTTCAGGACATCCGG +TTCGACCTTTTTTCTTTCTCCCGCTATCGACGACGCAGATCACGTATGAG +TTGCTTTTATATACGGCGATCGATTGGTCCGGTATACGTAAAATTAGCTC +TATATTTTATCGCTTTCGTTGCTCACGCGATTCCCAGGTATTTTAATGTC +GAATCATATTCCGTCACCTACCACTACGTAGGAGATATGCAGGGCTATGT +GAGAATAACTCAGGTTTCGTAAGAGTTTCTCAAGACTAGGGAGGATATTC +GCAGGTTGTTGAGTAATTTGTTTTTCCAATTAGCTATTCTCCTTGTCAGG +ACTTATTCAGGTGTGAGTCGAAGTAGCCCGAGACGTTTGGCCCTAGTATG +GATACTTCACGACAGTTTCAGACAGATTGTGGTCCGCCTTTAATGGGAAT +TATTTCTACTGCACAGGTTCATAGCTGACTTAGCCGAATGAGCCCCTTCG +ACGTCGCAATTTGGCGGTTAGCACACTTCCAGGAAGACATAGACGAATCA +CAGTTTCAGAATTCCTATACACTTCAGTAACTACGGAGTAAGGCGATCAG +TTCCTTGCCGCATTTATATGTTCATCTTAACTTTATTTTATATTAGCTCA +CGGCTTTCATTGGAAACTACAGATAACTGAGCCAAATGCTTCGCCTTTTT +GTCACTTTTTCCCAGTTCACTCAAGCCCAGAGTAGATGTAGTTTGAGGTT +ATCTACTTCTCGTTTCCATGTGCGGATACTAGCAGAGTTTCTCCTGTTAT +AACTGAGAGTCATTTCACACACAATACGGTTTATCTGTCGGCAGTTTCTT +CTCACAAGGTTTTCGCTATAGATGAATATCTGGTATAGGGGTGAAGAATC +TGTAATTATTAAACGCCTCAAGCTTATAGCCGTGACTGACAGTTATAGCC +CCCGGCTTTGCTGGTTCTACCCTATACCACACAAAACCCAAACCAATAAA +CCCATAATACTATATAATTCGTGTTGTCTTATTAGAGCGTAACTTGATCA +GGGAAAACGAATTCTCGGGGAGCGAAGCGATCCGAGAATTGTATGTTTTC +CCGAGAAAGTGAAGCGACAGCTTAAAGGCGCATCGCCTTTAGTGAGAGGC +AGGTCTCGACGCGACGACATCTTTCCTCGCGCGCAGCGGCGAGATTTCGT +CATTCTACGTGTTGGTTTCCCCCCTCCCGCCCCACACACATATTATTCCA +AAGTGCGAGACACATATGCTATGATTTCCCTTCCGGAGAAAAATCGAATT +ATTATGAAAATATTAAGTTTAAACCGTAAGTCGTTTATTTTCAGGAGGTG +AGTTTTATTTTTCCTTCATTGTCGCCTGAGTGGGCAGTCGGTGTCTATCT +GCAACATTCGCAGCTCGACCCTTGTGCTTGTTTTGGCGGTAGCAGGAAAC +TTATGGGTTTTTTCACAGTTTCGGGAGAGATATTTACAGGCTCTGGTTCA +GGGAACCAGATTCAGAGTTTAATAATGATATATCTTTACAGGAAAATTGT +GGTTAGAGTTTCATGGCAGCTTCAGATCCCCTGATGATCAACAGTTCAAT +CCACGGAAACACGGACGAAATGAGTGGTCCACCGAGCAACAATGTGGAAC +GAGACGATTCCAGGTTTTCCATGCCCCCTAACATCGATGATGGTCTTATG +GTAAAGTTCTTCCAATCAAGCGGTGTTCGTGTTTTGGATAAACTTCTTCG +ATAAGTAATACTTGACTAAAAAATATCGAGAATTAAAGTCACAATTAAAA +TTTACAAAATATTTTGTTCCAGATTATGAATTTTCGAAGATTAGACTATT +CACGGCCACGTAGCGTTTGACATGTTGTGGGACTGAATTTCTACAAAAAC +GTGAACTCACGTAGACTGTCTCTTGAATAATTTGAATGAAACAGATGTGA +GCTCCGGAATAGGCTTAGGCTTAGGCTTAGGCGGGGCTGGGAGGAGAAAA +AAATTGCGGAATTTGCCGTTTGAAGAGCTCGGCGAGTTTGCCGAGTTTGG +CAAATTTTAAATTTTGCCGTACACACTACAAATTGGACAAAAAATCGAAA +TATCAAAAATAACAAATTGTTCTGAGTTTGATCAGTTCGGTAAGAAAATT +TTGAAAAAAGTGATTTGCAGAATTTGCCAAGCTCGCCTTTGTCTTTGGTC +AATTTAGCACCATATGAGTGATTATTATCAATTTTCCCACTGTCGCTACT +TCACATTTAAAAAGTAGTCATCAATTGCCGAAACAACTTCCTTCCAGCTT +AAACTTTTTTCTTAGCCTCATCGGGACCCTTTCCTAATCCCTTCTTAACC +TCATTCTTCCCATCTTCCAAAATTTCCATCCTTCTTCTTCTTCTTCTTCC +CACTACGACCATCTTTGTCGTATAGCACCTTTCTCGCGAGAGTGTGTGGA +AACAATTTGCGAAAAACGGCTCCCGATCCCCCCATTCGTTTTGGCGAAAT +CAATAGACACAAAAATGTTCAAACAAATCTCCCCTTCTCGTTTATCCCCC +TGTTGCACAATATCCTTTTCTCACAAAAAAACCTTTGCTCTTCAATTTTC +GGAATCATCTTTTTGCGCTTTGTCGTGTTACTGTGAAAGGCGGAGTACTG +AAATATGGAAAATATTTTTAAATGACTCCCTGATTCCGAATATCTATGTG +AGAAAGTTCAAAAAATTTTCCCTCATTTTATATTTCAGCTTGAAATCGTG +ACTTTCATTGTGCACTAATGAGATTTCGATTTCGAAGTTTTTTTGAAATG +TGTTTTCAAGGTCAATTTTCAAGGTCAATTTATTATTTTACTATCGAAAA +ACTAAAAAAATTTCAATGAGTAAAGTAAGTAAGTAAGCATTTCGTAAATA +TACAAAAATCTCGTAAATCGACACATAGCGTCTCTGGCGCGAAAATTCGA +AATCTCATGGGTGCACAAATGAAATGCGAGATTTCAAACTCAAATGTAAA +ATAAGGGAAATTTTTTTGAATTTTGTCACATAGATATTCGGAATCAGGGG +CAAATTTGAAGTCAATTAAAAATATTTTTCAGATTTCGTGGTACTCTAGT +CTAAAACTAAAACTAAAACTAAACTAAAGTTAAATTAATATTAAATTACC +ATGAATCTAATTTTTGTTTTTTAAAGTTTCCTGCAAAAATTCCAAGATCT +CAGTTTGCCGAAGTCTAAATAACGACAACTCTGAACTTTTGTCCCGAAAG +AAATCGAACACCGGTGTATACTAATAAGATCCCTCGAAGCTCGGTATACA +AAAGGATCATGAAAAAGGGGTGTCTCACCTTGCGCATAATACCTTCTGTC +TTTCCCCCTTCACCAGAAAGATTTCCTTCTTATATTTGTTCGTTTCGTTC +CTGCACACTCTCCATCTCTTCTAACCCCCTCCTCATTCAGAATACTCTCT +CATCTCACAACGCTTCTGTCTACCTGCCTGCGTCTCCTCGGTACCATATA +CTATCTTGTAGCTGCCACTTACCAACAGACTTGCCTCTTGGAGGTCTCTC +TCTCTTTTCCACCAAATCACCTTGTTCTTCCGACTTGTTCTCTCTTATCG +AACTGACTTTTCGTGTCTGCGGGCCTTTCACATTATTTTCCAATTTTATT +CGAATTTTATGTGCCCACTGCTTGCTAGGTTTATTGAGTGCCGCATTAAT +TTTATTGATTAAAAAAAAAGCCACTTGTAACAATTTTTATGAAATTTGTT +TGCATATTTATTTAACAGTAGCGAAATTGTTTTAAAATTCGTACTGTGTG +AGAAATTTGCACTTTCGAAGTGTTTAAAACATTCTATTACGGGATCACAA +GATTATGAGAATGCTTATTGCGCAACATTTTTGACGCGCAAAATATCTAG +TAGCGAAAACTACAGTAATTCTTCAAATGACTACTGTAGCGCTTGTGTCG +ATACTGGCTCGATTTTTTAAATGATTTTTTTTCGAATAGTGACGTCGATA +TTCCATTTTGCTTTCTTTTTCGTATTATAATTTTATTCATTTCGAGAATC +GAGCCCATAAATCGACACAAACACTACAGTAGTCATTTAAAGAATTACTG +TTATTTTCGCTACGAGATATTTAGCGCGTCAAGATTTTTCCTTACGGAAA +TACAAACTTCTTGGCGAAAATTTCACGAAAATTCAAATTTCCCGCTTAGA +ATTTCCCGAATTTTTCGAATTTCCTGCCAAATAAAAACTAGTTTAAATAT +TTAAAAAAAAGCTTAGAATTCTTAGAATGCGTATTGCGCAGCATATTTGA +CGCCCAAAGTATCTCATAGCGAAAACACAGTAATTCTTGAAATGACTACT +GTAGCGCTTTTGTCGATTTACGGGCTCGATTTTTGAAATAAATTTTTTAA +AATCTTTTCGAATCAAGCCCGTGAATCGACACAAGCTCTACAGTAGTTAT +TCAAAAAGTAGTTTTGGCTTCGATCGAGATATTTTGTGTGTCAAATATAT +TCCCGTAAAACAAAATACCGTCTAAAGATATAAAATTTAACGCCTATTAC +ACCCCAAAACCCGCCGGAAAATCCAGAAAAATTATATAAATTCGCAGTCA +CTTCTCAAAAATAACCTGAATAGTTGACCGCGTAATTCGACCCGTTTCCC +TACGACTGACCACACCCCGATTCTCTCGAATTACCCGCGACAAGCTTAAG +CATCTTTCTTCATTCCCACACTTTTCGTAAACTTCTGAGAGACAAAACAA +TAATATTTCTTTCTCAAATCAATAATGCCTATATTCTCCGCATCCCGTAG +CCGATCCCATCACCGTAATTCTAGAAATCCCACGAAATTTTCCAATTTCT +CTATTGAAAAGGTCTCTCTTTTATATTACCCAGGCGCAAAATTTCGTGCA +AAAATACAATCGACGGTCTCGACGCGATAATTTTTGCTAAATTCCAAAAA +TGTGTGCGCCTTTAAAGATTATTGTAAATAGCTTCAAACTTTCACCGATA +TTTTTAAAAATTGATTTTTCTATGTTTTCCGTTTAATATATATTTATTTA +TTTAAAAATTAAGTTGAAATTGAGAAATCGATGAAAATCGAAAATTACAT +TACTCTTTAAAGGCGTACATGTCGTTTCGAGACCGGGTACAGTATTTTCG +ACTGCGATTTTGGTTTTTAAAAAAACCTAACCAATAGAATTTCCAGCGCT +CACACTCATTGGGTGGAAGCAGCAGCAGTCCGACGAGCTCTTTTTCGTCA +AACGACGAATTCGACGATCGTCAGAACAAAAAGTGAGTCATCAGTTTTGT +TTGAACAGCAGGTGTGAAATTTATTGTGAAATTTAAAATGGGAAATCCGA +AAAAACACACCTTGTGTGATCTAAGATCCAAAAAAAATAGAACAATCGAT +AATTTTCGGGTAATTTTAAAGTTATTTTTAGCGAAATAAACAATGCATTT +TTGAGGGATTGGTTTTCAGTCATTTTCGATTAAAAAATTCAATGTTGAGC +TGAAAATATCGATTTTTACCAGAAAATTGATAATTTTCGAGCTCAATACC +ACAATTTTAATGTTTAAATCGCTTTGAAACCTCATAAAATCTCCCGCACC +TCCAGTTTTTGTAGTTTTCCGCCTAAAATGTCGGAAATTCAACAGAATAC +TCATTTTCCTAGCGAAATCTATTAGTTTATAATAAATTTGATCGTTTTCT +GCTTAAAATTCCCTGAAACTTCTGAAAAAAAACCGATTAATCAGCTGAAA +TTCGCTTAAAACTAATTTCGTGCCGGGACCACGGCCTTTTAAATCGGTAT +GCGCTTTTAGTTTTGTACCGTATCTATTTTAGTTTTTAAAGTAAAAAATG +AAATTTTCAGCAAGTTTTGGCGTCAAAGAAATGTATCGAACGCAGAAATT +GAACGAATAATCGAGGATTTCATAGCGAATGGTATTTTAAGTGAGTTTTA +TTCGATAAAATCGACGAAAAACCAGAAATAAACAGTTAATTTCCAGAAAT +GAGCAACGGGAACAGCTACAATCACCATCACCAATTCCCGATGAGCATTC +CAATATCGTGCTCGTCACACTCAATTCAATCACAATCACGAATGAACACT +CTGAACGCGAATAGGGATCTCCTGTCTCCCGGCAACGACGTAATTGTCAC +CAGAACCGTGTCACCGTCGTTTTATTCGCATGGAATGCCGGCCCGGGATA +ATGTTTTTCGAAAAGACGATCATGTCAGGATATTGGGGAATACAACGGTA +TGAAAATCTGCTTTTCATCGAAAAAAATTGGAATTTTCAGGACCCAGCGT +GGTATCGAGCCCGTAATGCGAATCAGGAGGAGGGTCTGGTTCATGCAGAT +TGTGTAGTGAGAATAAAGTTGGTTTTTCTGATCAATTTCTGTGAATAACC +CCGATTCCCATGAAAATAGGATTTTCAGCAGAAACTCCAGGCAAATTGAG +TTTTTGATGCGAATAATGGATTAAAAAAGATAAAAATCCATGAAAATTTA +ATTTTTTACATCAAAAATCCATAAAAATCGGATTTTTGAGCGGATTAGAT +TACTTTGCCGAAAATTCATTTAGAAAAAAACAATTCTTGCGCGCAATTGC +GCAAAAAATTCAGAAAAATGAAACATAAAAGTTAAAAAAATTATTTTTAA +ATATTTTTGAGCTGAAAATAAAAGAAAATTCGGATTTTGTGGCCAAAAAT +TCAAGAATATTCCATGAAAATTAGTTTTTGTTTGCAAAAATCCGAACAAA +AATTAATTCTTTTTTTCGCTAAAAATTGAGAAAATGGTTTTAACACAAAA +ATCCACAAAAAATTGATTTTTAGGCCACAAAATCTATGAAAATTCTGATT +TTCTGGAAAAAAATTAAGAAAATTCAAATTTTTTGTTCAAAAACTTTTTT +CAAAAGCATTTCAAGAAAATTTGATTTTTCATCAAAAAAATTAATAAATT +TTAGCGGGCAAGCCTACGACAATGGAATTGTAAGAATGAGAGCTAGCGGA +TGTGACGTGGCTCCGGGAGCAGCTTCAACAACCTCCAGCACATCATCACA +TCATTCAACTGCAGCAAACCATCAGCCATGGTTTCATTCAATGATTAGCA +GAGAAAATACTGAAAAGTAATATTGAAAATGTTGGAAAAATCTGGAAAAA +TGCGTCATTATCTCGGTTTTCAGTCGGTTTCCAGTTTTATGAAAAAAACG +TCACTAAAAACGACATATTTCTTTAAAAACGTAAACATCGGAAATTGTTT +GCATGAAAAATGTCGCGATTTTCTAGAAAATTTTAAAATTTAAAGAAAAA +TGTTGAAAATAGATTTTTTCTGAATTTTTTGAATTTTATTAGAAAATAGA +GAAAACATCATGTTTTTCAACGTTTTTCGCCTGAAACGCTGGAAAATGCA +GAAAATGGTTTTTTTAGTGGAAAATAAAAATATTTTTTAAAAAAACGAGA +ATTTTTTTTTCGTCGAAAGTTCCAACAAAAATTACATGTTTTACAAAACA +TGTAATTTTTGTTGGAACGTCTTTTTTTTCTGAATTTTTCTTTGATTTTG +TTAACTTTCTGAATTTCAATTCAAATCGGCAAAATTGTACGCGTCTTTTG +AATGTTCCCACATCTATTTTGTAACGAATACGGGAAAAAATATTTCAAAA +AGGCACATTTTTCAAGTGTTTCCGCCTTATAAAAAATTGCCACTTCCGGC +AAATTGATATCCGACATACGGCAAATCGGCGAACTGACAAATTGCCGGAA +TCGAAAGATTCCGGCAAACCGACAACCCTCCGATTTGCCGGTGTCAGAAA +ATTGAAAAGTGTAGAAAAATGACGTCACAACTAAATTATAATACATGTCA +TTTCTTAATGTATTTTAATACAGTTTTGACGTCATTTTTCTCCACTTTTC +ATTTTTCCGGCACTACTTGAATAACCCTGTATACCACTTTTAAAAATCAT +GTTTTACAAATTTGTAAACTCCAGATTACTCCGCGGCAAACCGGACGGAA +CCTTCCTAGTACGTGAATCCACAAATTTCCCCGGCGACTTCACACTATGT +ATGTCGTTTCACGGAAAAGTCGAACACTATCGCATCGAACAGACGTCCGG +CGGACAGCTGACCTGTGACAAGGAAGAATACTTTTCCAATTTGACACAGT +TGGTCTCGGTGAGTCATTTCGGGGCTGTAGAGACAGGAAAAGGGGGAGGA +ATGGGTAATGAACCGGTATTCGTTAGAATGAGACAGGTGAAGATAACAGT +TATGATTTTATATTGTGAAGAGTTGTATTATAAAAAAGGTTGGTAGAGAT +TTGAATATTTGGGAGAAAGAGAAAATGAGGGGAAAATTGTTAAAATTCGG +ATTTAAGTTTGAAAAGTCACAAAAATGTTATATAAATATTTATATTTATT +GGATATAACTAATTAAGATTTTATATAGCAATACTTTAAATAATATGAAT +ATTGTTAAATATTGATATAATATCATATCAATCTTCATTTAATGGCTAAT +TGTAATTTCCAATTTTCCAGCACTACAAACGTGACGCGGACGGTCTCTGC +CATCGCCTGGTAACTCCGATTATTTGTGAAACAGCGACATTTTCATCAAA +CGGATCATCGTCATTTGGTTCATCGTCGACAGTTGATTTGGAAGATCGAA +CATCAGTATTTCGACACGCGGGTCTAGTTATTTCATCGAACGATATTGAT +GTTGGTGATACAATTGGACACGGAGAATTTGGAGATGTTCGATTGGGAAC +TTATAAGAATCGAAAAGTCGCGTTAAAAGTGTCGAAAAGGCATGGAAATG +GAATGTTGGACTCATTGCTGGATGAAGCCAAGTTTATGGTGTAAGTTATC +AAATTATTGAGAAGAAAATAATTTTGGCAAAGCCCAAAACAATGCGTGTT +GAACAAAGTCATATTAAAAATATATTTATGTTTCAAAAATGTTATAATTC +AATTTATTTTTAATTTCGAAAATCTATAATAACAACTTTTCCAAGTTTTT +AGTTATGAGTACCCCGAAATCTGAAAAATATTTTCAATTGACTCCAAATT +TGCCCCTGATTCCGAAAATCTAAGTGAAAAATTCGAAACCTGATGGGCGC +ACAAATTATTTGTACAATTTAAACACTTTTTAATTAAGATTAAAAATTTC +CCCAATTTTTTTGAAAATATTCATTAATTTCTATTTTATGTTAATAATTG +TTTCAGTTTATAACGCTTAGTTTCAAAATTTTCAATTTTCCTGATTGATG +ACTGATAACTAATGGCAGCAAATAAATCTGAAAAATTCCGAATTTTGCAG +AGGTCTCTCGCATCCAAATCTAGTGACACTTGTCGGTGTTGTACTGGATG +ATGTGAATGTCTACATGATAACTGAATATATGGCAAATGGTAATTTAATC +GATTTACTCCGATCTCGAGGAAGGCATGCGTTGGAGAGGAGGCAGTTGAT +GATGTTTGCGATGTAAGAAAAAGTTGACAAATAAAAAAATTGGAATTTAA +CATTCAAATTAGATTGTTCAAAAATTGTTGACATTTCTGCATTTTTATAA +CCGAAAAATCGAAATTTCATTTTTTCCGCCTGAGTAATAGTAACTCACCA +CGAAAAGGGTTACTGTAGCAGTGCTTTTAGCTGTCTCTGGTTTAGAAATT +TACGATTTGCCGGTCTGTCTGAAACCCGATTTTTTCTAGATTTTAAACAA +TTTTCTAGTATCCTGTTGAATTAATTCCAAAAACATTTTTTGCTAAATTT +TTGTTCTCCGTTTGTCAAAAAGCCGACTTTTTAAAAACACTGCAAAATTT +CTCTCTAAGTTTTTTAAAAAATGTTTGCCCTTGAAATCAATGCAGTTTTT +TTTTTAAATTTTATTTTGGAGTTTTTTCGAACAAAAATTTATTTCTTCGT +CTATTCGTACCGAAACACCAAAAAATCCACTTTTTTTCGAAATTTTTTTT +TTCAAACAACAACCCTGATTTCAAGGGTAAACATTTTTTAAAAAATTTGA +AAAAAATATTGTAAAATCGGTTTTAGTTTTTAAAAAAAGTCGTTTAAATT +TGTTGCACAATTAAAAAAAAATTTAGAGAAAAATCTTGCAATGCTTCAGG +CACACAGCTGAAAATGCTAATACAGTACTGCTTTTCGTGGTTGGACCCAG +CCGTGGTTACTGTACCTCCGGCAAAGTGGAAAATTCGATTTTTTTTTGTT +AGAAAATTTGAAAATGTCAAAGATCTGATTTGAATGTTTCAATTTTTTGT +GACAGCTGTTCTTGAAATCCAAATTTTCAACTTTTTTTCCATTTTCAGGG +ATATTTGCCAAGGAATGTGTTATCTGGAATCAAAACAGATTGTTCATCGA +GACTTGGCCGCTCGAAATGTCCTACTCGACGATGATTTAGTAGCGAAAGT +TTCGGATTTTGGATTAGCGAAAAAAGCAAACAGCCAGTCACATGATTCGG +CTTCTGGCAAATTTCCGATTAAATGGACGGCACCTGAAGCGCTTAGACAT +AGTGTAAGTTTGGTTGAAAAATTGAAAAAAATTGAGAAATTTTTACAGAA +TTTATTCTTTCAAAATTAATTTCATAAAAAGAAACAAAATCATTTCAATT +TAAATTGGAATTTCGTATTCTTAAATTTTTAATTTAAAAAAATCGATATT +TTTTAAATTTAACAAAATTTGAAAAAAGAAATCCGAAAATCCGCCGGAAA +ATGCCTCAAAAATCTGCACTTTTTTTGAATTTTTGCCCAAATTTCTAGAA +TTTTCCCTTACTTCATTTTCTTTCATAGCTTGAATATCAAAAATGGGAAA +ATCTTGAAAAAAAATCCCAAAAAAATAAAAAACGAAAAAATCGATTTTCA +AAAGTTTATTTTTTAAAAATTTTTGTGATTTTTTTCTGATAAAAATAGTT +TGAAACTAGAATTTTTAGAAAATATCCAAATTTTCTAATAGTTCGCTGAA +AAATGACTCAAAAATCACCAAAAAATATTGAATTTTCGCATAAATTTTTC +AAAAATGGAATTTTTTTCATTAAAAATTAAGAATTTTTGCAATTTTCCCA +AATTTTTTTTAGCAATTCACCACAAAATCCGATGTTTGGTCATTCGGCAT +TCTTCTTTGGGAAATTTTTTCATTCGGACGAGTACCGTACCCAAGAATTG +TGAGTTTTCAGACAACATTTTTTTAATTAAAAAAATTTCTCGTGTTTTTT +CATATTATTCCTCGCTAGCTGTTGTTTTTATTTCTTGGTTGGGATCATTT +CTTTTAAGGCTCCACGGAAAGGGAATCTGCGCGAGAATGAGATCTACGAA +AATGAGCGACGATGCTAGGATGAAACGCGCGTTGTTTAGCATGTTTTTGA +GACTTTTCAAAAATAGAGTTTTTAACCTTTTTCGTAGATCCTCTTCTCGT +AGATTCCTTTTTCGTGGGTCCTCTTCCTATATTTTCGGCTTGGCCGAGTT +TTCTCCCGGCCACGATCATCACTATTTTATTGATTTTTGTCATGATTTTC +AGGGAGCCGATGGTCGTTCGGTATGTGTATATTGCATTTTTTCGTTAGGT +TCTATTTTTTTCAAATTCTATCCACTTCTATTATACAATACATCTCACTA +TCTTTTCCCCTGCCTGAAATTTTTGAAAAAAAATGAAGAAATTTTAATTT +TAAACTTTTTCCAAAATTTTCCAAAAAAAAAAGTTTTTTATCAATTTTTT +CAATAGCTCGAATTCTGAAAATGAAAAATGATGATAGAAATTGTTTTAAA +AAAATGATTTTTTTTGTTGCAAAATTTAATTTTTAAATCGAAATACAACG +TTTTTTTCAAAAAAAAAACACCTTATTCGAGACAAAAATAAGTTTCTTTT +TTTTTCAAAATTGAACATTTGGATTTTCTGGAAAATTGAATAATTAAAAA +AGATTAAATGTTCGAAAAAAAGAGAAATATATATTTATTGGCTTATTTGG +AAAAATCAAAAAATAGTAAGAAAAAAATCAAAATTGTTCGATTTTTTATT +TTTGTTTTGTTTCCGAAGATGTCCTTGTGGTATATAGTATTTTGGGTCCC +ACCACGAAAATCGCCGTGCGCCTTTAAATTCGGCCGACCACGTCTCGCCT +AAGTCCAGTCCCCCACTAATGTCAAAAAAAATTTTTTTTCGCAAAACCTG +AATTTTGAAATCTTTTTTCCAAAAAAAAAAACGTTTTTTATTTAATTTTA +AAAGAAAAAATTGGAAAAAAGTATTATTTTTTCTAATTTTGAACTTTTTA +AAAAAATTATTACACATTATCTGGATTTTCAAAATTTTCCATATTCGATG +TTAAAAATTATAAACATTTTTCAGAAAGGAACACCGAAATTTTTTTTAGA +AAAAAGTCAAATTTGGAGCGAAAATTATGTTTTTCAACAATTTTTCAACA +ATAATTTTGTTCAATTTTTTTTTTGGATCCAAAAAAATCTGTGTGTTTTT +GTGTGATTTCCGGCACCCAACTCCCCAGAATTTCCCTCAAAAACTCTATT +TTTTTCTCTGCTACCTCTTCTCAATCTTCTAATTAATTCTATGTTTTTTC +ACTATTTTTTATTATTTTTTCACCCCTTTCAGAGCTCATTTAGAGCCCAA +AAATAACCATCAGAAACACAAAAAAAACAACTTTTTTTTTCTTTTTGAAT +TAATTTTTTCAGCCTATCCAAGACGTTGTGAGATATATTGAGAAGGGATA +TCGAATGGAAGCACCTGAAGGATGTCCACCGGAAATTTTCAAGGTTATGA +ATGAAACATGGGCTCTATCGGCACAAGATCGACCGTCTTTTGGACAGGTA +GATTTTTTAAGGGAAATTTTTTAGAATTTTAAGACGAAAATCTGAAAAAA +AAACCTACAATTATGGCAATTTTTGTGATGAAAATCTACAAAATTGAATT +TTTTTTCGAAAACCTGATAGAAAAAAGAATAAAAATTAATTTGAAAAATG +CCGTAAATTGACCAAAAATATGGAATTTTTACCAAAATTTCAGGGGTTTT +TCAGATTTTACCAGAGTTTCTGCCTTATAAATTAAAAATTTCAAAGAGAA +ATATCTTTTTAAAATCAGCATTTTTAGCAATTTTTGTGATGAAAATTGTT +TAAAAATTGCCAAAAATGGGAATGTTTGAAGAAAATTCAGAAAAATCTAA +ATTTTGGGCAATTTTTGCAATAAAATTGAAAGATTCGGAAAATAATAAAT +TTTTCGAAATCCTGAAAAAATTTCACAATTTTTGCGAAAAGAATTGTAGA +AAATTCGAAATTTTATTATTAAAAATATTGAAAAAAACAAAAAATTTCAA +AAATCCGCCGAAAATGGCTTAAAAATCTAAAAGAAAAGATTTTTTGCATT +AAATTTTATTGCATTAGTATTTGCGAAAAACAAACCCGAAAATTCACTCT +AAAATTACAAAAATTTCAATTTTCTGAAGCTGCGTCCACAAAATGGCTTT +AAAAATCATTTTCATGTACAATGTCAAAATTTTAAAAAAAGTGAAATTTT +GTTCAGAAGTTACTATAATAAAGGTTTTTTGCTTTCCGGTCATTTTTTTG +AATTTTGGAACATTAACCGAAAAAAAAATTCCGCATTTTTACCCTGAAAA +ATGCGAAAATGTTTGAATTTTTTGAAAATTCCACTTAAATTTTTTATATT +TTCAGGTCTTGCAACGATTGACAACCATCCGAAATACAGTATGACATCGG +CGCACATCTCGAAACTTCCAGAAATCCATCGAATTTTCTAGTCCATATGA +TGTTTCTGTTTTTTTTTCGCTGTTTTTTACACAAATTTTGTCATATTTTA +TTGTAATTTCCCCCACACATTTTTAGGCATCGTTATTATATATTTTCTAA +TCCGCTGCCGCGCATTTCGGGAGATCCTGGAATTTAAAGGCACAGCGGTG +TTTTTGGATGGGTCCCACCGCGAAAATTATTATGCGCCTTTGAAATTTTT +TTTTCGATATTCCTAAAAATCACAAAAAACATTTTTTTTTCTAAATTAGA +GAAGTTTTAGCCTTTCTTTCGAAAAGTCGATTTTTTTGGTTTAAATTTTT +CTCGATTTGAAAAAAATTTCAATTTTTAGTGAAATCAAAGAAAAAACATC +AAGAAACTTCTATTCGAAAGAATTTTTTAAAATTGTATTTTCCGAAATAA +TTTTCTCTGTTGGGTCTCACCACGAAAATCGTCATGCACCTTTAAATTTC +CTTGCCCACACCTCTCCGAACGGCCGATACCCAATCTACGGTTTCTTCAA +TTTTCCTCTGCATTTTTCATCGATTTTTAAAAATTTTTATCGAATATTTT +CACGTTTAAAATTATTAATTTGCAACGAATTTCCCTCAACAAAAAATGCT +CAAAACTCCGCCCCTTTATTGGCATAATTTTTGCCGCCACGGAAAATGCA +ATAAATTTTATATTACTTTTCACCGATTTTTTAAGATTATTTTTAGAACT +TTTAGTTTTTGTATGTGTGTGTGCTCGTAGTTTATCGGCAAGAAATTATT +GTTTTTTTTTCTTAATTTTTAATAAGGGAACATTTTTTAAAGAGATTTTC +AGAAAATCGGTAAAGATTTAAGATGCTCTGAATATGTCCAACTTCACAAG +CTTCGTAGATTACGCGGAAAAGGTGATTTTGAATGTTGAATGTGCAAGTG +CGCCCTATGGATAAATGGAGCAGCGTGGCAATTCGAAAAAATTTAAATAA +AAACGTATTACTCGAAAGTTCACAGAGTTTTTCACCAAAAAATTGAAAAT +TCGCTGAAAAAGTCGCGGGACATTCCATTTTTATTTTTCGGGAAGAAATT +CGAGAATTGACTGAAAAAAGCGCGTCTTTATTCCAGAAATTTTAGCGGAA +AATTCCAGATTTTTTTATTTAAAAAGACTCAAAACATGAAAAAAATATTC +TGGAGAAATCAAAAATTGATTGAAAAGTTTCAGTTTTAGGCTAAAATTTT +TTTGCGAAAAATTCATTTAGTTTTTGTTGGTAAAGTTCCGATTTTTCTGC +AAAATTTGAATTTCTTTCTGAAAAAGTGCGTTTTTTTTTTCAAAAAATTC +TTAAAATCGGAAATTTTTCGCCCCGAAACTGAACCGAAAAATTCGAAAAA +TGAAGCGCGGTCAATTTTTGAATTTTGGCATTGAAAATATTCTGAAAAAT +TCAAAAATTGACGGAAAAGCTCAAAGTTTTTCACAATATAATCGATATTT +TCTCATTTTTCAATGTAAAAATCGATAGTTTCAGCCGCACGTCGCAGCAA +CAAGCCAGACACCAATACCGCCGTCACCGTTGAACGAAAAACGGCCAATT +CCACTGTTTCCAAGTGAATTTATCGATTTTTCTGTAGAAAAATCTGAAAA +TTTCTGAATTTTCAGACGAAATCAGCAGCTCTTCGTGCGATGACGTCTCG +TTTTCCATGCAATTCGGAGAATCTGAGCAGGGACATGTTATATGTACAAA +AGTTCGACTTCGATTCTATCCTGCCGTGGTGAAAGAGGTTCGAAATTCAA +AAAAAAAAGAAAACAATATTACTATACATTCGTAAAAATTAAATTTCAGT +TTAAAGGCGCATCTCACATTTAAATATGCATTATTATTCATTAGTGTCGA +CCCAGATTGAAAGCGCATGCAAATTTTGAACTTTAAAACTGGAAAAAAAA +TTTTATTACACATTCGTGTAACATGAATATTCAGTTTAAAGGCGCGTGCT +AGTTTTAAACTTCAAAAATTAAAAAAATATATATATATTCGTGAAAAAAT +GTTCTTTTTAAAAGCTCTTTAAAAGTTTAAAAATGATTATTATACGTTTC +TCAAAATTTTCAAAAATCAGGTCAAATGCACTTAGAATATTGGAAAATAT +GAAGAAAAATCTTTATACATTCCTGAAAAAATACGCATGGTCCAAAAGTC +GACAAATCGTGGCCCAATATTTTCTATTTTTTCAGAGAAATCTTCCGCAA +AGGTCGAAATTTTTCGACGATTTCTACGATGTTCCGCTCACTGCGATCGC +CAGAATTGAGGTGGCCATTGTGAAAGGTGAAAAATATTTTTACTTCAAAA +AATTATTATATTAAATTTACACATACACATTCGTGAAAAAATTTTGCCGG +TAAAAATAATGAAAAATATATACAGAAAAATACGGAAAATTTGGATGAAA +AATATTTTTTGGTGACAATTAGAATATTACCCGCAAACAAAATTCAAATG +AATTTTTTCAGTTTTTGAAAATCTAAACAAATTTCAAAATGTTATTATAG +ATTCGTGAAAAATTAAAACTCAGTTTAAAGGCGCATTTCATATTCAAATG +AGAATTATTAAACATCTTAAAGACATAAACAAAAAAAATGAAATCTGAAG +AAGAAAAATTATACATTCGTGAAAGTTGGGAACAAAATTTTGTAATTTGA +GTGCTTGACATCAGTTTAATAAAAAATTTTGAAACCAAGAATTTTCGAAA +AAAAATCACGTATACCTAAAAACTTGTAGTTTTTTAAAGTTAGTAAACTA +TTTTCTCTCAAAAATTCAAAAATATTCCAGGTAACAGTAAAGGAAAAGCG +GACAAATTTCAACGCCTCGAGACAAGCCTATCAACAATGGAAACAGTATC +AATAATTCGTCTAATATTAAAAGATGTCAGAGTTGTTACAATTGACTTGA +GAAGATCTCAAAATGCAAATATATTGGCTAATCAAATACTCTACTTCTCG +AAAAGTGGACCAATCGAAAAAATGACTCAAGTTGGAGCTGCTATGGAGGA +GCGCGGTGTGAAGGCGAAAAGTAGGCATTGGATAATTAGTATTGGGGGTT +GGGAGGGGAGGGAGGAAAGTTCGAGAAAATCGGAATATCTTATAAATATT +AGGCCGTTTGATTAATAAATCGACACATCAAGTAAATAAATTTTGAAACA +AATTAAAAATTTTAAACGTTTCGATTGATATATGTGTATCAATTTTTTAA +AAGATGTATATTAGTAACAAACAAGAAATTTTTTATTCAATAAAAATATA +CTACGGGAGCACTAAATTTTTAGAATGCGTATTGCACAACATATTGGACC +AGATATCTCGTAGCGAAAACTACAGTAATTCTTTAAATGACTGGTGTCGA +TTTACGGGCTCTTTTTTCATTTCTCCGTATTATTTTCTCTTTTTTGCTTA +ATTTTAATATTCTATCTATAACTAAAAAATTAATTCATTTCGAAAATCTA +GCCCGTAAATCGACACAAGCGCTACAGTAGTCATTTAAAGGATTACTGTA +ATTTCGCTACGCGATACTTTGTGCGTCAAATATATTGTGCATTACGCATT +TTCAGAATTTTGTATTCTCGTAAAATTTTCGAAAAAGTAAATCTTTTAAA +AAACTTTTTATTAAATGAATAAAAACGCATTTTTTGGAGAATCGGATAAA +AATAATTTATTTAAGTTTTGAAATTTTAATATTTTGAAAAAAAAACATTT +TAATTGGAAAAAAATATGAAACTTTCTTTTGTAAATATGGTTTTTACAAA +ATTCCCGAATGTCCAATATACAAACTTATCATTTTCCAGCAGCATTCAAT +AGCTACGAAGCATGGCGTTCGGAACTCCAAAGGTGCCAGCAGAAGACGGA +TTCAACGTCTGTCTGGAAAATTGTAGCACTTAACAAAGAAGGCTTCAACT +ATGCGGCTCAGGGGTGCGATTTTTGGAAAAAAAAACTGGATTTCCGATTA +AAAATATGTATAGTGTATGTATTTTTCAAATTTCCAGCTACCCTGTGTAC +GTAGTAGTGAGCAACTTCTTGGATCGTGTGGACATTGAACGACAACTACA +ACACTACAAACAAGGACGATTTCCGATTTGGGTGTGGTCTCGGGCGAACG +GACACTCGGCGTTATTCGTTTCGGCGGATCACGAGAACAATATCGCGATG +CCGGCGATTTTGGCGAAGTTAGTACATTATATTTTAAATTTGTAAAATGT +TATTTTCTTCCAGAATGCAAGAAAGTATCACCCGTTGCCATCCGAATAAC +GAGAAGCCGCATGTTATAAAATTGGACGTCGATTTTGTGTCGAATGTTGG +AAAAGCTTTTGATAATCTTCTATCGCTTTGTGCAATTGGTGAGGGAGAGC +ATTTCATATTTAAAAAAAAAATTATTCGCCGTATTTTCAGCTGTTTTATT +TTCCATTATTTTCCATATAATATGCATTTTCCCAGACTCCTACGAGCAAT +ACGTTACACTGCAAAACGGTTGGAATACGAAACTCTCGAGAACCGGATGG +CTTCATCTCGTCAAGCTGTGCCTTCAGACTACCTATCAGACGATTCAATG +GATTGTTGATAGAGATCGATCGGTTATTTTACAGGGTACTATCAATTTAG +GTTTTATTCAGAGAGAGAGAGATAGCAATTTTCAAAATATTTACAAACGA +GTTAGTCATTTACATCCACAATCGACTGATCAGAATCTGATTCGTGGCCG +TTTTCCTCCGCCAGAACTTTAGGAACTTGCACCGAACTACTTGCTGCTTG +ATCCTCCCCCTCCAGAGGATCTTCTCCAGATGGGATACAACTTTTGATGA +AGCTGATCATCGGATCCTCCTCTCCATCATCCGAACTAGTTTGTCTGAGA +AGAATATCAACCAGTGTCTGCATTAAATCACCGGGTTCCGTTCTTGCTCG +TCGAGTACTCAAATTGTGTCGGCACATGAATTTGTCCAACCATCCGCGGG +ATGCCTGAATGATAAAGGTGGAGTAGCGTCGAATAGTTATTTTTTATGTT +TTTCATATACTCGTTTGCATTAAAGTAACGGCTCTCCTACCTTGAAATCC +GAGTTCTGACTGATTTTCTTTGCCGTTTCACCGATGATTCTTCTGGTGAC +TCGTTGTTTCTCCTTACGCTGATCGTGAACCCATTTAATCAATTCCTTAT +CAACGTCGTCATACTTTAAAGGTCTTCCACCTCCCGAAAGTCGCTTTGTT +GCAGTTGAGCCGTTGTCTTCTCTGAAAGTGTTATTTGCCAAAAGGCAGCA +AGTCGAAAATTTTTCAAAAAGAAAATTTGAAATCGAACAGAGAATTTATG +TTATGCCCGTATTTCAAAATATAGGAATAGTTGAAATGACTTCTTTTGAT +AGGATTAATTATAAGCCTAGAAAAAATCATAGTATTTGGAATAAAAGGTC +CATAAAAGGTTCTCAATTGATAGGGCTTGCATGTAGGCGTTAAACCCTGC +CTTTAAGGCGACCTCCGCTTGCCTCTCGGTTACGCCTTACGTTGTGCTAA +AACATAATCAATCTTTTTTTTTTTAATTTCTATTTTGATTTTCATCAAAT +TGAGAGAAATGAGAAAATTAGAAATTTGTAAATTCACATAGGCGGGTTTC +AAGCAGGACCCTGACACCGCGCATGCCTAACATGAAAGTCCTAGCCCTGG +ACTATTTTTTTGAACACAAAAATATGTCCGAAGTGGCAAAACTTACAACT +GCTTCTCGATTTCAGCTTTCTGGGCGATCCACTGTTGAATGTTTTGCCTA +TTCACATTCAAATCCTTTGCTGCTTTCGATATATTCTTATGTTCAAGGGC +ATAATTTATGGCATGCAGTTTGAACTTCAAGTCATACGTTCTTTTTCGAG +TTTTTACAGGCACTTCTGTAGGGATTTCGCTCATTGGTTTTCTCTGAAAA +ATAAGTATATAACAAGCAAAGTCTTAACTAGTCAGCAAGTTATTGGAAAT +AAAACATGTGAGAAAAGCGAACGAAGGGGCAAGACTAATGGAGACAGCAA +ATTGGCACACACGCAGAGAGACATGGCTAATAGAGTGTGCAAGACTATTA +GAGGGTAGAGGCAGTGAGACGAATTTCCGACTGGTCAGAATGTAAAGGGG +GTGCAAGGCTAATAGGAGGAGACAAGACAAATAGAAAAACTACATTATTA +TATGAAAAGAGAGTAAGACTGAATACGTGTATGGGCACCCCACATATTTG +TATGTAAGTAGTTATGTAAATGACTTTTTGGAATTGAAAAGAAAATACCA +AGAAATGGAAAAAACCTCCGGTCAATCGTAAAAAAATTATGAAAGAAGTT +CGATCTACTCGGCTACGATTTACAGTTTCCCTTACTGATTTCTACTAAAA +TGCATTAATCTTGAGTTTATCTCTAACAAATTGATGGTACTTTTGAATGG +TTATAACACCGGATATTTTGCAGAAGACGAAGGATCAGATATGTCGATTA +TTGTGGCCAGCCTCACGCAAATGTGCTGTGATCCATTTTACAGAACAACT +ACGGGTGAGTTTATTAAATGTTTTTTCTGTACTAAAAATGGGGTTTAAAA +AACTAATTTTAATTTAGTTCTCTCCTTGTATTAATTTCCAAAATTTTCCG +AAATTTTTTTTTCAATTTAAAAATCAATTTCAGGTCTTCAACAACTCATC +GAAAAAATGTGGATTGCCCTTGGCCACCCATTTGGTGAACGGCTACTCGG +AAGAACCGACGATGATCCATCGAGACGTGGAAAACCACAGAATAAAATGA +GAACTGACGTCATGCCGACGTGGTTGCTCTTCTTGGATTGTGTTTCACAG +CTACATCGAATATATACATTTGAGTAGGTTTGGTAAAAAAAATGTTTTCC +CCCGCAAAAAAATGTTTTCCTCAAAAAATTTGAATTTCCCACCCAAAATT +TTTCTCAAAAATTTTTTTAAAAATTAATTTTAAAATTGTTTTCTCAAAAA +ATTTGAATCTCCCGGATTTAAAAATTCCAAAAATTCGTCTATCAATAAAT +TTTATATTGTTTTCGAATTTCGAATCATAAAAATTAGTTTCAAGTTAACA +CACCTTTTTTTTCAAATAATTTTTTTAAAAAATAATTTTAAAAACAATTA +ATTTTTTTCCTATTTCCAGATTCACATTCTCTCCACACGTTCTCATTGCA +CTATGGGATCTTTCATTAACTGGAATGGTTCCATCAATGGCTTGTAATAA +TCTGGAAGAGCAATTACTCGCAAAAGTCGGCGGTGGACCATTCCCATTGG +ATCGATATTTTGAGAAAAGCTACTCGAAATTATTTGGAAATATTTGGCAC +GACGCAGTGCTTTTTATGGAATCTATTAAGAAAAGTTGGTGCTTTTTAAG +AAAAAAATTTTATATCGATTGTTCTTTTCTTTTTGATTTCAGCTACTTTT +TCACCTCGGTCAGCAACATTTTTTTGCAACATTTTGGACGTGGCCGCGAA +AAAAAAATTGGTGGCCGAGTTTTCTTTTTTTTCACTGCCATTAATTTCCG +AGAGGAAAATCTAGGAATTAAAATTTTTTCGAAAGTATACAATGTTGACC +GAGAAAAAATCGGTGGCCGAATTTTCTCTTTCTTCTCTGCCACGTTATTT +TAGTAAAAAATTAGAAAAAAAAACACAAAATGTTGTTCAAATTTTGGAAA +AAGTCTGTAAAAACAACAAAAAATTGATGGCCGAGTTTTTTTTCCATTTT +CGCGGCCACGTGACAAGCAGTGATTTCTCAAATGTTTTCAGGAAAAAAAA +ACAGGCGGAATTCAGATAATTCTACGAAAACTATTTTTGTTTCTGGAAAA +AAGTCAAAACTTGAAAATCGGTGGTCGAGTGTTCTCTTTTTTTGCGGCCT +TATCTCGATTTTTCCAGATCAACCAGTGTGTGCTCACTCGAAATTCCTTC +AATGTGAATTTATTCGGCCACCGACGTCGTTTTGCGATATTCAACTGTGG +TCCGAGTGCTATCTTCGATGGATTCCTCCGGCAAACGGGAAAAATTCGGG +AAAACTCGGCGAAGAACTCTCGCTGGACGAGAAAATGATCGAAATGGCCA +AAAAATGGAACAGTTCCGAGTGGAAAATGCATTTGGACCTACCGGAAGAG +GTGACCAAACTTTTCGGATTTATAGGCTCTAAACATATTTTTACTTTCAA +TTCTTAAATTTTTAGTATTCATCTGCATATCCTTACTCGATTCCGGAGAT +TTCCCGCCCAATAATGGATTTAAATGATTTTGATATGATCCGGCCGGATG +ATTTCGACGCAATGTCCATGAATTCATCCATCAACTCATATTCGTTCGTT +AATACGGTAGGGATACTTATTAGCTCGGAAAATAAATTACGACATATTTT +GTCTCGAATTTTTTATAGGTGACTTATAATAGACATTTAGTGTCTAGGCA +CACATAAAAGTTAGATCTTTTTCAGCTATCGTTTCGATACTTTCACACAA +AAGTAGGTTTTTTTTCGCAACTTTGTAAATTGAAAAATCAATAGGTCGGC +AAATAATTGTTGGCGTATTTTGTCAATTCACGATATTTATCAAAAATTTT +ATATGTGACTTCTGGTAGAAATTTATTATGGTTGGCAATAAGTACTGAGT +CAAAATTCATATAACTTGTTTTGTTGCTTATCGATTTTTTTTAATTGCCG +GAGTTCATGTTATTAACTATGGGCTTTCATCTGAAAGTAGTCACAAAACA +TTTTAAAAACTCGAAGTGATCCAAGTCGAAACAACTTTTTCAAGGTTTAC +GCCCTCTTATTTTTTCTCTTATTTTCAGCATTGATATGAGTTTATGTACG +GATCAAGAGTGTCGGTTTTTCGATTTTTGTATAAAATCGAAATTTTTTTT +TTGATTTTTCGATTTTCCCTGAAAAACACACAATTGAAAAATGTCACTCT +TGGTACGGATATTGCTAAATCTATTATACAATGTGAGAATCCAATAAAAG +TTTTATATTTTATTTTTGCAGCCAGTTCGTAACAACACGACAACAGAATC +AATATTCGATCATTCGACACTTGAGAAACGAAATCGTCGAGCAGCTGCCA +CAATTGGCTCCGAATCGCCAGTTATTCAAATGAGACCAAAAGAGCAAATT +GTCGGATATTCGAAATATGCATTTGATGATTCATTATCACCAAGACCACA +TTCCCGAACTGTTGAGACGCCTATTTTAAAGAATGTACGGGATTTTTGGA +AAATTTAAAATTTGGAAAATGAAAAATTCAAACAAAACAATTTTTTCGCT +TTCAAATTTCATAAAAATTTATGTTAAAAATAGTTTTTAATTGAATTTTT +AAAAAATTCTTACTGAAAACTTTCGAAATAATTAAAAAAAAAAACCAAAC +TATATTTGTTTTTTTATTATTGAAAAAGTTAAAAAAAATGTTTTTTTTTG +ATAATTTTACACTGCTCGCCTTCAAAATTTGATGAAAATCTTAATACTAG +ATTTTTTTAATTTTTCATTTAAGACTTTTCGAAAAATTCGAAAGTTCAAA +AAAAAAAATCCAAAAAAAATTTCACTCAAATCAATCGCCTTCAAAATTTG +ATAAAAACTCGATGAAAATTTTGTGGAATTAAAATGTTTAATTTATCATT +CTGAGGCACCACGTTTTCAAGATCTGGTGGGATTCCGGATCTACATTCTT +CATTTCAGCGCAAAATCCCTAAATCCGGAATTCCACCGAATCTTGAAACC +GTGGTGCCTCATCATTCTACCTTTAAAAACTCGAAATTATAAAAAATTCT +GCAAAACTCTAAAAAAATTTGATTTTCGATTTTCGAAAATTTATCTTTTT +TTGTATTTAACATTCAATAAAATATTGATGAAAAAATTTCTAGAATCATA +TTTTTAAATTTTGCTTTACAAAATTTTTTAAAAATCTACAATCGTTCACT +TTCTTGCCTTCAAAATTTGAATGAAGAAAAAATTTCAAAAACTTTAAGAA +TTAAATTTAAAATGTGCTCAAAAAATTCTTTAAAAATATGCGTTTCCCTA +ATAATTTCCATGTTTCAGTCCCCATCGCCCTCCTACACCCCATTTCACCC +GACGCCCGTTCACCGGAGCAACACCGTCCGTGCCGACAATCGCCCAATTC +CCCCGCCCCGGCCGCAGGGCCTAGGAACACTGACCCCATCACGCCCCGAG +ATAAGAGCTCATCGAGATGATATAGAGAGCCCTACTATTCGGGTCACAAG +ATTTTGAAGAAAAAGTTATACTTTTATTTTAATTTCCGCTCAAAATCGGA +ATTTTCTATAAATATGCCCCTTTAAATTGAGCTACAGTAGTCACGTCGAA +AAATTTTCAATTTTTTTGAATTTTTTGAATTTTTTCATCCAGTTATAAAA +AAAAGCTTGCCCCTCAGCTCTACCCCATTTTTCTTTCATTTGTCACCTAC +TTCCTTCATATATGCCCGGTTAATTATGTATTTTTTGATGCTTTTTTAGT +CCCGCCACGGTTTTTTTCATTTCGAAAAGTCGATCGATTATCGATTTTTT +CGAAAATTTGGAAAATTTGGAGAAAATCTAAATATTATCGATTTTAAGCT +AAAATTTTAAGATTTTATTTTTTCAAATAAAATTTTGGAAATGTTTTTTT +GAAAAAAAAAGTGCAAAAAACACTCAAGGGAAAATTTTTAAAAAATTGGA +AAAAATCTTGAAAGTTTGTCGATTTTTCAGTGTGCATTTTGGAGTTATCG +GTTTTCTTTCCGAATTTTCATCAAATTTATTTTTGATCTACCAAAAAATC +TCTAAAACCCCGTGGCGGGAACCTACTTCACTTTTATTCTGCATAATTAG +ACAAAAATGTGATTATTTTCTCATTTCAAAACTTGTTACATATTTTGTGT +TGTGATACATATGTCTAAATTTTTACGGACTGAAAAAATACTTTTTTCTT +AATGTTTTTGAAATTTTCATTATTGGTGGCGTCATCCATGTCTATTTGAT +TTTCCAGACCCCCCCCCCCCCCTCTAAAATGAAAAGAACAAGACGATTGA +CAGCTAGCATGTGCGACGATCAAAGTACCGATTTGATTCAGTTGAAGGGA +CACGAGAACGCGAAAAAGTCGGAAGCCCATCTGAAAGTGCTGGAATACAT +TGGCAAACGCTATGAAATTCGAATGACCGACGGGCGGTACATACGTGGCA +CGATGATCGCCACTGACAAGGACGCTAATATGGTTTTCAACAAGGTAAAA +ATTTGATGAAAATTTGGTCCAAAAGCTCATAGTTTCAAATATTTTTCCTT +AAAATTATGCGCCGCAGGCAAAACAACATTCCGCCTTTTTCTATTGCTGG +CTTAGTTTTCGCAATTTTCTCGGCTACCAGGCTACTGCAAAAATGATCGA +TCCGTGAATTGTGCAAACATCTGAGTTACACAGAGAGTGGGGCGGAGCGG +AACATCGCAACACTGCCGCATGGTTTTTCCACAACTTTTTTTTTCAAGAA +AGTTTCGATTGTACTTGTTTTTTCTCTTTTTTGTATAAAAATGGTATTCA +TTCTAAATAATTCACATATGCTAAATTGCATATAAAAACATGGAATATCC +TCTCAAATTAAGAGTCTTAATCTTATTAGAATTAAATTGGATATCATTTT +CATTCGAAAAGAAAGAGAAAGAAACAAGTAAAATCGAAACTTTTTTGAAA +AAAATGCTTGATTTTATTTCATTTTCGTTGTTTTTTTTTCAGTATTTAAC +TTTTGAACGATCGATTATTTATAAGGTTTGCGGTTAAAAACGATGAATTT +CGTGTTTTTCTTTTCTGGATTCAAATGACAAGTTTTAACCAATTCGAATG +TCAAACACGGAAAAATAAGCGAAAATAACAAAAAATCGTGTATTGTAACC +AAAAAGTTCTCCACGAGTAGTACACTAGAGCCGACGCGCCGCAGGTTTGC +AAAACAACGCCCACCCCGTTTTCTGCGCGGCACTACACAATTTTCTATCT +CACGAATAAATATTTCAGAAAAGGCAGGATTTTGTCTGAAAATCATGAAA +AATCAAGTTTTTTTCAGGTTTCCAACGCTGAAATGGTTGGAATTAGGGTT +TGTTACCAAAAATCGTATAATATTAAAATCCCAGTGCTTCTCTGTCTTTC +AGCAATTTCTTTTAATTTCCAGGCAGACGAGCGATGGGACAAAGATCCAC +AATTGAAAGGAGTCCGATTTCTAGGGCAAGCGATGATCTCGAAAAAGCAC +GTGGAATCGATGCACGCGTTGCCGGACCCTAAAGAAACTGAAATTTGATC +CAGTTTTCTTATTTTCTCTAATTTATCCCATCCTTTTCTTGTCAAGATTA +ATATAAATTAATTTTTATCGAAGCGATTTTTGTTCATCTCATCCAAATAT +GAAAAAACATTCGAAAAAAAATCGCAGGCTTCACTTGGAACCGCGCGCCA +TCAGTTGAAAATGCTGAATATGTACAAAGACTGGAAAATATTAAATTTTT +ATGTTTAAAATTTCACGTTTTTCGTGTTTTCCACAAAAAAGCAATGCATT +GTCGTTTTTCAAAAAACACTCATGGTAAACGAAGTCCCCGTGGAGTACAC +GACAATGTCGCATCGAGACCCAAACTGGGAAACGCCTGCGCCTTTAATTT +TAGGAGTTTAATTTTCGAATTTCGAGTTATTTTTTTCTCAAGTCTTTTTG +CGACTTTTTTTTGAATATTTTATTACTTGTAGCGCTGAAATATGACAGTT +ATTATAGCGTCACACTGGGGACCTCAATCAAAACAGGTATTTTTCAAAAT +TTCGCCGTAAAATCTAATAACCAATTTTGAGATGTTGCCACCCGAGCCCC +CACGGATAATTCTGAGAGAAGTTCCGGTCCAGAATAACCAGAAAGAGCAT +CCACCGGTTCAGGAGATCAAAACCGTGTCCAGCAAGTCGAAGGAACATCG +CGTCAGTTCGAGCCGGAAAATTCCGGATCACTTCGACGTGGGCCCACGGT +TCTACATGAATGTCCCCGCAGATGGCTCAGAAGTGTTCGAGGACGACGAA +AAAGACGTCGAGAACGAGTGTTGGGCGGTGATCGAAAGAATAGGAAGCGA +GGATGACAAGTTCGAGGCCTCTGAGCTTGTCGAGTACCGCGATCACGATT +GGTACATCGCTTTGGCGATTAATAAGGAGAAAACGCCGGATAAGGCGAAT +TATCAAGTAGGAATTACGAAAAAAATTTTGATTTTCAATCTCATTTTTTA +AATTTCAGCACCTACTCTACAGCTATCGAGGCGGAATCCAACGCATAATT +CTCACGCCTCAACAGACGGATTCGATCGACAAAACGCCGCTAGTGAAGTA +CAAAATCATCGGAGACGGTCTGTACGAAGTGCTTCCGATTCACTCGTCCC +TTCCTCAAACTGGTCTAATCAGTCCCAAATATCGTTACAACAAAGGCGTC +GAGCTTCGGATTTTCGGGATAGTGAATTGGATTGATTTTGTGTTGGACGA +CGATCATCAGACGCACAGGACGATGGTTTGGACAGATGCGGTCGGACCGA +TCTATCTGAGTGCCGCGGATCGAGCCAATATTCGACGGAAGCTGCTGCTG +ACCGAGATGCAGATTTTCGCGCCGTTGCGAATGTGCCATATTACTGTCAA +GGCGGAATTTAACTTGTTAGTTAAAAAAAACGCGTAAAAAGAATAATAGT +TCCAAATTTTCAGCTCGATTCCCGATGGTTCCCCGATTCAATGGACCATA +TCATCGTTCCAGCCACTCATCGAAGAATCAGAGAAGGATCCGAATATTGG +GCGCAATTTATGGCCAGCGAGAGTGCTCAGATTCGATGATTTAGTCGTTA +CAAAGAAGGTGCTTAATCATTTTAATATTAAATTTTAACAGCATTTATAA +TTATTTATCTATTTCCAGACACCGAACGGCTACTGGCTGAAGTCTCAAAG +ATTGGAGGGTCACGTTAATGTGTTCGCCGGTGCAAATCAAATCGGAATCA +TTGAGTCGGCGGGTGAAAAATACGCGACGAAGGGAAGCATGATGGCGTTC +GTGGTTCCGTGCTATCAGAACAGCACGTTTGCATATTTCGAAGCACTTAT +CGCCGGACCCCCGCGAGTCGTGATGATTATTACCGAAGGACGCTTTCTGA +ATTATTGCCCGAAGACGTGGCCACCGTCTGTTCGGAAAATGCGTGATCAG +TATCAGAAAGAGCACGTTGTAAGCACAATTTTCCAGAGAAAAAGGCTTTC +GATAAATTTTCTTATTTTCAGCTGAAATCCGAAGTCCGAAGTTCACCAAT +CTGCATGAAACAGCCGGATTATTGCCTCAAATCACTACGAGGATTCAGCG +AGTGCCCATTTTGATCACTCAAAGTTTTATATATTTCTGTATTTCTTCTG +CCTTATTTTAAAAAGTATTTTCCCGTTTTTTTTCTTTTGTTCAATTTTCC +CTTTTTCTTTACTTGTTATGTCCTATGTTTCATGCTAAATTAACGTATAT +TTTTAATTAGCAATTAAAAAACTTTCTGATTAACTGCCAGTTTTTGAGAA +GAACCAGAAGATGGAACGCAGGCGAGTTTCTGAAACGGAAAGGGTTTGAA +ATTTTTATCAATCAAACAAACTCGCAATTTTATCAAAAACCATGCCGTCG +TTGCAAGTTTGAAAAAACCACATATATTTGCAACATTGATAGAATATCAT +TGGATCGTATGGATCCGCCATGGCCAGACCATCATATTGACATGTACCGT +TTAATGGGTTCGGTACCGCTGAAAAGTTGTTGGTCTCGCAGCGAAGTACT +ACAGTAATCGGGAAAAAGCGCTGTTTATTATCGATTTTTCAATTAAAAAT +CAATAAACTCGCCGCGAGATCCAAACCTCAACTTACGATAGCTTTTTGTA +GGAGTCGATTGTCCATCGACAAGGAAGCCAGCAACTAGGAAAATTTTGAT +AGGGAGAAGCATTGAAATTTAATTGTTTTTGGGGGTTTCGTTTGGTTTTT +ATAGGAATTTTTGAGCTGTAAGAAAACAAAGCAACATTTATTTCAATTAA +AACCGGAAAATATGAGTCATTATGGGGGGTTTTCAACCGTACGGAATTTG +ACAAATTTGAAACTACCATAAAATGGTTAGTTTTGTAGTTAGAGAACTCA +AAATTGATTTTCTAAGACAAAAAAATTGCCCTTTTTCAGAATATAGTAGG +TTTGTATAATTTCCAAAAAATTATTTTTCTTGCCCAAAAAAAAAAGGACA +GTCATTAGATGGCTGAAAAAAAAGTGGGCAAAAATAAAAAGTGTCTAATT +TTGTTGAAAACGGGTAATTAATATATGCAGAATTCAGAAAATCTAGGTTT +AACCCATCAAAAACCATTAAAAAGTGGCAAAATTTGGCAATTTTTGCAAA +AACTCACAATTTTGAAACTCCTCTAAATTGGTTCAATTTGTAGCTAGAGA +ACTTAAAATTGGTCTCCAAGCCCTAAAAAATTGTCCTTTTTCAAAATATA +ATAGTTTTAAACGTTTTTAGAAAATTTATTTTTCTTGCCCAAAAAAAAGG +ACAGTCATTAGATGGCTGAAAAAAATTGGGCAAAAATAAAAACTTGTCTA +ATTTTGTTGAAAACGGGTAATTCATATATGCAGAATTCAGAAAATCTAGG +TTTAACCCATCAAAAACCATTAAAAATCTAAAATGATTAATTTTCTAGTT +AAAGGATTCAAAATTGATCTTCGAACACTAAAAAGTTGTCAAGTATCCAA +AAAAAGTGGTTCAATTTAAAAAAAATTGGTCAGGGAAAATTATCGATTTT +TTCGCCGCTTCGCAACTTGGACGAATTTTTCTTTCGCTGCACAAAAATCA +ATAATTATTGATTTTTTTTCTAAAACAGAAAAATAGATATTTGCACTTTT +CTGAAAAATCGATATTAAACGGAAATTCGCAAAAATCGATGGTCACTAAT +TTTTTTGCAAAACCCCAGTAAAAAATCGCTTTTTTCGCCGCATTTCCTAA +CTTTTTCTATGCCACCACTATTGATTTTTTTTCCAGAAATCTTGGAGCTT +CCCAAACCCGCTCATCAGCCCGCGTGCTTCATCAATCATTCCGTTGAGAA +CTATGAATTTTTCGAATGAAAATTAAAAAGAGGGGGATTTATTAGACTGA +AAAAGTGTTTTTGTGCCACGTGGCGGCGGCCGAATTCTCCTGGACGGGAA +TTTCTAGGCCATGCTTGGGGGAGATGAGGAGATGGGGGTCAACTTCAAAT +GTGTGTAACAAAATAGAAAAAAAACTATAAAAGGTAAGAGGAGATCAAAG +GTCACGCCACTAGGGCTTGAAAAATGAATGCCTGCCTACAAATAGACATG +TAGGAATGTAGGCAGGCAGACAAAAAGTGGGTGAACAACGAGAAAAGGCA +CGTAAAAAGGGGTAAAGGTTAGAGAAAAAGAAAAAAAAAGCTCACAGAGC +ACATTAAAAATGGAAAAAAACGAGATCATTGGATATTCTGCTGCCGTTGA +TCATCGTCATCATGAATGATCAGCTGATTGGGGTCGACTATCACATCATC +TGGGTTCACGAGAGCATCTTCTTCGAGCAGCTCATGCGGAGGATGATCGT +CGTGATGATTTGGCTCTTCCACAACCACTTGTTCGAGGACATCTGGAATT +TATAGAATTAAAAAATACATTTTTTAGACAAGAAATCGACAAATTTCTGT +GTTTATTTCTATTTTTCAGATAATTCCACACAATTAGATAGTTATTGAGT +TTTCTTTCTATAAATTTCAAAAAAAAAAACGATAATTATTGATTTTTTTT +TAAATCAAAAACTTCACAAAACTCAATAATTATATATTTTTCGTCCTCAT +TCTCTTTCGGTTTTGTGTGTGTGTGAGTTTTTTTGAAAAACGCAAAATTT +TCTGTGATATTTCTATTTTTTAACCTGACATGGGCAGTTTTTGAAAAAAT +TTTGCAATATTTTCGGTGTTCTTTCTCAGAAAAACTCGAAAAATTGCAAA +ATAAATGTAAAATTTATCAAAAATTACACATTTTCGGTCAACCTTTTGCT +CAGAGAAACTAGAAAAAAAATTTCAATTTTTTTGGAAACCTGCCAAAAAA +TGAAGTTTCAGTGAAACATTTTTTTTATCTTTTTTCGAAAATTTAATACA +TTTTTTTGCAATTTTTTAATATCAATCCGTTCTCACATTTTTTGGTAAAA +ATATGAGGAAAATGAATACATTTTGGATTTTTTCAGAAAATCTGTTTACC +ATTAATCTGCTTCTCCCCAGTATAAACTTTAGGCTCATTCTCGTGCACTT +CTTCTTCCAAATTAACATCATCACCAACTGTCCCAATAACTTCTTCCTCG +ACAATTTCCTCAACAATTGCTCCATCAGGAGCCATATGCAAATGCATTTC +TCCATTATCCATTTCTTCTCCAGCCATTATTTCGACTCCAAACGTGTGAT +TCACTATTTGCAAGAGACGATGTTCGCTTTTTTCGAAGAGCATTTTGAAG +AGCAAATCGAATGTCTCGTTGTCGGTTGCTGAGCCAAATGAGTTCTTGGC +AATACGGAAGAGAGCCTCGTTTCGACTTGTTCCACGCGCCATTCCAGATT +GTGATAGAGGCTGGAAATATTACTATTTCAGATTTTTAGATTAAATGTGG +AGCTGGGAAATTCGAGTTTTCGACGAAAAAATAGCCTTTCAAAAGATTAT +TTTCAGATATGTTTAAAAAAATTCCGTTGAAAACGACGAAATTAGATAAA +AATTGGATTTTCAGCACATACACGGGCGTTTGATTACGTGGCCGTGAAAA +CGGAGAAACTCGGCCACGTAGAAACAAAACCGAAAATTGCAGAAAATCCA +GGAATTTTTTTTAATGACTCCGAAATTTCCCCGATTCCGAATAATATATA +TGAATGAATATATACTTCTGAAAAATTTCAAAACCTTTGCTCACCAAGCC +ACTACTCTGCTGCCCAAAATTTTTAGGCTCCTGATATTTCGCCTTTCTAT +ACGGCAGCTGAATCTGTTGCTGGGATGATGATGGTTGCTGAATCTCTTCG +GTATGTGAAACCTGAAGCTCTCGCTCGTCGAGCATCTCCTCAAGATGCAC +ATTTTTCTTTCTGGATCCTCCTTCTGAAGCTTCTGCTGAAGCTCCAGCCG +TGTCAGTCGTCCAATCATCCACAAAATCACCCGCCGCCGCCGAAACAATC +ATCTCATTCTTCAACTCGTACGGATCATGATCATCTTCAGCATCCCGAAT +ACCATCAGTCGCCGCCATAATCTCACGACGTCGTACATAATAGAGCATCT +TCGTGTTCACCTGAATCCCATACTTCTCCAAAATCACTTTAGCCACCTCG +GCAGGTGTCATTCTCGCGAGCAGCCGGAGCACATCCTCCCGAATGTGTGG +TGGAAGACGTTGAAGTGAGTATTCTTGAGCGGAGCTCATCGTGCTCACGT +TAACCGGAGCCGGCATCTCGCCGGGCTCAGTGTACCAGTAAATGATCATT +GCGTTGCCGATTTGATGGCCATTCTTCAACACGTACGTCACCTTCTTGCG +AAGACGTGGACAACGTGGAAGGGTGGCTGTGTAGACGTGAAGCTGGAATT +CGATGAGATCCGAACGATGGGATGATGGTGTCTTCCAGATGCGTAGTTGA +CCTTCTCGATTCAGTGCGAGCGCTTGTTTCGCAGATTTTGGACGTTTTGT +GATGCCGTCTGAAAAACAGAAAAAAAATTAAGTTTGGAGCATCTTGAATT +TGCCTTTTTTACTTTCGGAACGTCCCACTTTTGCTGATTTTTCGTGTTTT +TTTTTCTGGAATTTTGGAATTACAGGGAATATCTCTCCAAACCAATTACA +GGGAATATCTCTCCAAACTGGCCGTCGCAGGAAGACTTCACTTTTAAATT +GTTTTACCTGTAGGCACAAAAGCAAAAGAGGAGAGCCTACATCTTTGTAT +CTTCGATAAATTCGTTAAAAGTTCTTTTGTCTTTATTCATTTTTCAAATT +ATTTTCCAATGTTTTAAAAACATTTTTTCTAAACTTTACAGTAATTTGGG +CTATTTTCACTATTTTTCAACTTTTTGACGCGTTTTTAATTCTTCATTTC +AACCTCATTTTGTCCAAACTTTCTCAAATTTCCACATAATATGGCCGATT +TTCATGAAATTTTCATAATTTACACCAATATATTCAATTTTTAACCTCAT +TTTTTTCACAGAAATTCCCAACATTTTCACATATTTTTCATGACAAATTT +GAATTATTTCAATGTTTTCCAAACTTACGAGGATTGGTGCTAGTATTCTC +TGACCACGGAACCAGTCCATCACACGTCAAATTTCTTGCATCAACCTCGA +GCCCATCAATAAAGAAAACGAATGCGGCTTTGCCAGTTGTGGCTGGCGGA +AGGGCCGGTACTCGATTGTTGAGGCATCCGAGGGACTCACTGCAAAAAAA +TCATCGTTTTTTCTAGAAATGGATCGATGTTTGTGTAACTTTATCGATTT +GCTAGAATATTATCGATTATTCCGAAAAAAAATTTTAAAACAACAACTGT +ATTTCTATTTTTATTTTTTTAAAGATAGACTTCCAGATCATATTTTTTTT +GAAAATTTATTTAAAAAATTATCGATTTCTCTAGGAAAAATATCGGCTAT +TCTCGAAACTTGTGGATTTCCCTAGAGATTTATCGATTTCTGAAAAAATT +ATCGAATTTTCTAGAAATTTTGCAAATTTTTTCATAAAATTATCGATTTT +TCTGAAATATATCGACTTTTCGCCCAAAAAGTACGTACATCAATGAAGGC +TTATTGACAAGAAAGTGTAATTGTCGATTCCTATCATTCCAGAACTCCAT +ATCCAACAGCTGAAGATACAAACTACCATCATCGGCGGCTTGTGCTGGCA +CAGCAAACGGGCATTCTTTCTCGCATTCCGACATATCCGACACATCATTA +TCGATATCATGTATCTGCGTTGGCTGGAAAAATGGATCCTACACGCGTTG +AGCACACACTTTGTGAGCTCTGCGAGAGCTCAATGAGAACCTACCGGTCG +TTTTGTGGCTCGTTTCGCGAATCGTTTCAAATATCCGCCATGCATTCGTG +GTAGCTCGCCTTCCTGATTATAGTCGTACATGATGAGCGCATGGCTCACC +ACGAGCCGTGATTCGGTTTCCATCATGTAATAGATTTTTTTGCGTAGTCG +TGGCTCGCGTGGATTGATGGAATACAGGAATACCAAGTGGAATGGGCACG +TTTTGTAGTCCATGTTGTCTTTGGTCTGTGAGGGGTTTTGGATATTATTA +CGGGAGGCATAAAATTCTGAGAATGCGTATTGCACAGCATATAGACCAGA +TCCGTAAATCAACACAAGCCCTACAGTAGTTATTTAATAAATTACTGTAG +TTTTTGCTGCGAGATATTTTGCGCGTCAAATGTGTTGCGAAATACGAATT +CTCAGAATTTTTTGTTCCTAAGAACAGCTCGTCAATTTTTTTTTCAGTTT +TTCAGGGTTATTCAAAAAAAACCTGTTTTTAAAGCTTCTAGGTCTCATAT +TTAAAAAGTTTTGAGAATTTAATACATTTTTTTTAATAGAAATTTGGCAA +TTTTTTCATCACCTCATCGTCGATTATTCTTTTTGAAAAATTTTCGATTT +TTATGGGAATATATTTATTTTCCAAGAAGATTAACTTTTTTTCAAGAAAT +CTGAAAATTTATCAATTTTTCAAAAGAAATTAATGAATTTTATCAAAAAA +AGAATAACTTTTCCAGAAAATATTTTTTTTTCTTAAAAATTAAAAAAAAA +TTGTTAAATCGCTTTTTGTGTCAATTTTTCAAAAAAAAAAAAGAGGCATC +GAGAATATCCCATTTTTTTCGAAAAAAATTTTTTGGTTATTTTTCTTTTT +TTAGATAAAATGTATATACTTTTTTAAAAATGTTTTTTCACCAACAAATT +TTGATATTAAAAAGTTGGAATTTTATGACTAAATTATGGAAAACTTTTTC +GATTTTTAGAAAATCGGAAAATTTTGAAAGTGGGCGTCGTCAAAAAATTT +AATTTTTTAAGAAATTATAGAAAATATGCTGATTTTGGTATTTTTGGAGA +GCGTCGATTTCCATCGGATTTTTTTGGTTGTTTTCCCTGGGATCCATGTA +ACACCTGAAACTGTGATCCCAGCTCATCACAAATCACTCCGACTTTGCGA +ACTTTCGTCCGATAGCACGTCGGATTCTGTGCATTTCCATTATGAGACCA +TGGCGAGAAGTCGTCACGATTGATGTCGTGTGGAAAGATGGCTGTCCCGG +CGACGAAGAATGCGTACGCACGAGAATTACGAACAATTGGTGGGTGTCCC +GGCTTCGCGTAGTTCAGCAGACCACGTTCTTCGCTGGAAAAATGATGATT +ATATCGAAACATTCGAGGAAAATGGATAGAAAAAACGAAAAATTCAATTT +TTATCAAAGTTCGTTTATGTTGATGAAAACATTATTACGGGAACACAAAA +TTCTGAGAATGCGTATTGTGCAAAGTATCTCGTAGCGAAAACTACAGTTA +TTCTTCAAATGACTACTGTACCTATTGTGTCGATTTACGGAAATAATTTA +TAAATCGATAAAACAGTAGTTATTTTTAGAATTACTGTAGTCCTCGCCAC +GAGATATTTTGCGCGTCAAATATGATGCACAATACGCATTCTCCAAATTT +TGTGTTCCGTAATAAAAAATAAAGTTGTTAGATGAATATTCAGGGTCTCA +ACAAAATTTAATCTGTGTTTTCAGTTTTCATGTTTTTAGAGTGGAAAACG +TTTTTTTTTCAGAAAACAGTCAGAAATGTAGATTTTGTTCCATATTTCAA +AAAATCATTTAAAAAATATAGAACATTTTTTTGAAAAATCAAATTTCTCC +AGAGTGTAGTACGCCATTAAAGGTCTCGTCACGATTTTGTTTGTTTTCAA +TTTTTAAGTTTTTGAAGTAGAAAATTATTTTTTTTAGGAAAATTTTTCGT +CGATTTCGTTGAAAATTCGCTAATAAACGGGGATTAAAAAAAACGAAATT +TTCCAATTTTTCGAAAAAAAAAATCGAAAAATTCCTCCCAAACTTACACA +ACATTGGTATTAGCAATCCACTCCAACACGGCCTCAAACGTGCTGGCGAC +CCTCTTATGTCGAACAGTCAAGTAGATATGTCCCGTTTCCAATTGCCGGG +GATTCTCAAAATAGGGCGCCGGGTTCTCCTGCTGAGTAAGCGGATCATCG +TCAAACTCCAAATCGTAGCCATTGTTGAGCACATCCTCTTGAGACATATC +CAACAAATCATCGTCTAGCAGATGTCCCTGAGCGTCTTGAGCAATCGAAA +CATCTTGCATTAGCTGATGTTGCTGCTGCTGGTGCTGATCGTGTTGAAGC +TGGATCTGATCTAGGGAATCATTGTGATGTCCGATGACTTCTTCTTCCAC +AACTTCCAAATCTTCTACATCTATAAATTGTTCTTCATCATTCGGTGCAG +CAGATGATGTAGATGGATCTTGTGATGTATCAATCTTCTTCTGATCGTCG +ATCCATTTCGATCCTCCAACACCTCGTCCAGGTGTTCCAGGTGGTTTAAC +ATACGGACACGGAACCGGACCATCTCTCACATATTCATAGATATAACACA +CATTTCCGATCGTAATCGTATTGTTGCGTTGAATATAAATGAGACGCTTC +CGAAGACGGGGACATCTCGCCAGGACGGACATTGTTTCGACGAGACACAA +CTGTGACGAGTGCCAGCCGCCAGCCGTGTCTTTTGCCATTTGGAACTGGC +CGTTGTCGTCTTGGACGATGGCTCGGCGAGTTGAGCGGACGCGGGGTGAC +GGACCTTCCGAGGCAGCTGAAATTAATGAAACTACGGCACTCTGTACATC +TCCGGAGGCACCACGTTTTCAAGATCTACCAAAACAAGATCTACTATTTG +GAGATCTACGAAAACAAAATCTACGTTTTCAAGAAATGGTACCATGCTAA +TTGCAGTTTTCGCAGTTTTCTCGAAGAACAACAAATCAACAATGTTGACC +GCCCAGTGTGCTCCGATGTCGCGTGTTGTTTAGCGTTTAGAAAAATCTTT +TTTGAAAGAAAAACTTCAGGAGAACGATAAACAACGCACGATGAGTAATA +TGGAAGAATTTTTGTTTCGTTTTTCTTTGAGAAAACTGCGAAAAAGTGCT +AGATCCTGAAAACGTATATCTTGTTTTGGTAGATCTTATTTTCGTAGATC +TTGTTTTTGAACAGATCTCGAAAACGTGATGCCTCAATCTTCTGCAGTTG +CCGAATTTTCACATTTTTAAACCTTAAAACATATTTTTTCTAAAACTTTT +CCAAAAATCGATTTCTTCGTTTTCACGATTTTTTTCAGAGAAAATATAGA +AAATCGAAAATTTGTAAATTTTCGATTGAAAAAATGGAAAAATTACAGGA +AATTATTGAAGATTTAAACTTGTTTCTAAACAATCGAAAATTATCGTTTT +TTTTCTTTTGGAAATTTTTTTTTGGATTTTTCCCAAAATGGTGGTTTTTG +AAATCAAAAAGCGTTAAAAACAAATTTCTTTTAAAATTACCGGAAATTAT +TTTAGAAAATTTCCGAAAAGTCAATAAATTAAAAAATCGAACAAGAGAAA +GAGTTATTAAATTAAACAAAAACAATTTCACAAAAGTCGATAACTATTGA +TTTTTCATCAGAATTTCCTAAAAGTCGATATTTTTAAACCTTCTGATAAA +TTCTTTTTTTGTTAAAAAAAACTTTCGATTGATTAGAAACACGTTTAAAT +CTTTAATAACTTCCTGTAATTTTTCCTTTTTTTAATCGAAAATTTACAAT +TTTAATTTATTCTTTTAAAAAAATCAAAAAACGAAGAAATTGTTCGTTTT +TTCTGGAAAAATTAATTCTTCGGCTCGAAATTTCGATGATTTCTTTTTAG +AAAAAAATATATGTAAAAAATTATACAATTTCAAATAAAACACTGTTTTT +TTTCTTTTGATATTGAAAATAGTAGAAATTTTTCAATAAAAATTCCAATT +GTTCACTCAAAATTTCAAATTTTCGACAAAAAAACTTACGATTAACAGTC +CACGGTGACAGTCCATCGCCAGTATGATTAATCTGATTTGCAACAAAATT +CGCCGGCACAAAGTACACAAAAACGCCGGTTGTCGGAATAAGTGGCGGTA +GGTACGGTGTTCGGCGATTCAAACAATTCGATTGGCTCAGCAGCTCGGGC +TCATTCACCAAATATCGGAGGAGAAGCTTCTTGTTGTGTGCCCAACCGAG +TTTTGCAAGTTTTACGCGAAGAAACATTCCACCACGTGGTCCTTCCACTA +TCTCGTCTTCGAACTGGGAATTTTTTTTTGATGAATTTGAGAAAAATAGT +TTAAATCTTTATATTTCAGTTTGAAATCGCCGAATTTCAGTTGTGCACCT +TCGTGTATATTTACGATATGTTTAATCTTTTTCGGATGCTGATTTCCGAT +CTTTAACGGTTTTCCTTCATTTTCGTCGGTTTTTTTTGGATATGTGTTTT +TGAGGTCAATTAATGAACCATTTTATTATCAGAAAACTAGCAAAATGTTC +AATACTCGACAGAAAATCCATATGCTATATGCTTTTCTCGACTGAAAACC +GGAAATGTTGCTAGTTTTTGATAATAAAATGTTAAATTAACACATTTTCA +AAAAAAAAACACTTCTACAAAAACCGACGAAAATTAAAGAAAATCGTTGA +AAAAACGAAAATCAACACCCGATAAAGATTAAGCATTTCGTAAATATACA +CGAATTTGGTAAATCGACACATGGCATCTCTAGCGCGAAAATTCGAAATT +CGTAATTTCCAGCTGAAATATTAAATCAGGGAATTTTTCTGAATATTTCA +CTTAGATATTCGGAATCAGGGAAAAATTTGGAGTTCTTATAAAAAAATTT +ACTAAGCAAAGTTTTAGCAATTTAGGTTCTAATAGGCTTTACAAATATCA +AAAAGTCCCGATTTTTCAAGGATCTATATATATTTTTAGAACCACAGATT +TTTTGCTGTTTTTCAGCATTCTCGGAAGACCATACCGGTGTGGATCCGGG +ATCATCCAGATCTAACGAGACGTGCGGATCAGTTGGATCGACCATCGCAT +GTCTTAAATAGTCGTTTCCGTGCGGAAGATTTACGATTGGTGGAATTTCA +CCGGGACACGTGTAGTCGTAGAGAATGAGCACGTTTCCATAGATTTGGCC +ATCGCGGGAGAGGTAGAAAATCTGGAAAAAATTTTTTGAATAGATTTTTT +CGCCTTTTCTGAAGGATTTTTTTTGAAATTTGAAGGAAGACGGGTTTTTG +CTTGCATAGACTCAAAATAAACCCTTTAGAAAATTTTTACGTTGGCTCAA +AATATCGAGAATAAAAACCAATTTTTTTCTAAAATTTCGAAAAAATGGGC +ATAACGGCGGAAAATGTATTTTTATTTGATTATTGTACCTTTTTCAGTTC +ATTTTGGAGCATTTTTGGCCCATAGGCTTAAAATTAACCTTAAACATTTA +AAAAACGTGAAATAAGATATCAAAAAGCCATTATGGCCACTATGACCTAA +AAAAAATATTTAAAAAAAAACAACTTTTTTTTGAATATTCAAATTTTCTG +AAACTGATAATAAACCTTTTTTCTCAATCTTAACAGTCTCGGCAGCCACG +CGCTGTACTCGGTGAGATGAAGTTCGGCGATACGTGGATCTCCTTTGACC +GATTGGAGCCGTCCGTTGAGACGAGCAACCGGATGACGTCGGACATTCGG +TTTGATGACTGGATCGTTGAAGTGTTGCTCGCCGCCAGTAGAGCTCCATG +GCTTCAGATCGTCATTCGAGACGTCTTTTATCGACATGATTTTGGAGCCG +TCCACGTAGAATGCGAAACAGGCTTTGTGTGGAACAAGTGGTGGGAGACG +GGGTGGTTTGTCGAGAAGCCAACCTCCTTCGCGACTAAAAATGGGGACCG +TTGATTTTTGTTTTTTTTTTCTGACCGATTTTTCGGACAATAGCTTGAAA +TTTTGACAATTTTCTTTATTTTTAGAAGATATTTTTTTCTTATATTTTTT +TTTCTCTAAAAACTATAGTAAAAAATAGTTCAATTTTTTGTGGTTCTGGC +GAAAAATGTATTTTTTCGAAAAAAATTTTTTTTTTTCAAAACAAGATATT +TAGATTTATCACTGAAAATTGCTAATTTCCAGTGCGAAAAATGACTTTTT +CTGGCTATTTCTGCCTGATTTTTGATATAAATTCCAATTTTCACAATAAA +ATTGCTGAAATTTTCTCCTTTTTTCACTGTCTCCGTACATCATTGCAATT +TCGGTCTCGTTGGTGAGCAGCTCAATTATTCGTTCCTTTCTGAGAAGGTA +GGCCAGGCAGCCTGATATCACTGTGGCGTAGCAATCACCGTTTTCCGTCA +TTTCAACTTCATCTTCGAACTGCAAAAATTATAGAATTGAAAAAAAAAAA +CGATAAAATCCGACTTTCTCGATGATTTTTATGATTTTTAACTGAAAAAT +TGATTTTTCGGCATTTTCTGAAGGATTTTGATTAAAATTTGAAGGTTTTT +TTTTCTCCCGTAGGCTCAAAAAACGCCCTTTTTATGGCGGCTCAAAGGCA +AATTTTAAGTAATAATCGAATAAAAAATCATAAATTTACGACCCCTACGG +CACGGGAAATTGGAGACTTCAGCTAAAACTAACCGTTGATTTTGAATATT +TTGAGCCAAATTTGGCCAAATAGGCATTAAATGCACTCCAGATGACTAAA +AACACGTGAAAAAAGCTATTAAAATTAGGTAAATAAGACAAAAACAGAAA +AAAAAGAACTTGAAGCGAAACTGGAGCCCATTTTTGGAGACAATTCTCAT +TACAAAATTGGTTTTTTGGGCACATTTTTTAGTCTTTCTAGTTATTTCGA +ACATTTTCCGAAGAATTCCCATAAAACTTTGAAGCTTTTCCATGTAAGCC +CCTACCAATTTCACGTGGTACTGCCTTTCAGCAAGAGCTTTACTGATAAC +TCGTTCTCCTTGAACTCGGAACATTTTCGACGGTGTCGCCGCCGCCGGAT +TTATAATTTTCATCGCCTTCTTCTCCTTATCCCCATCGTCGATAGACCCA +TCGGTATCCATTGGCTTGCGTGTTCGGACACGTCGCTGTTTGCTGGGCCT +GGAAAATTTCGATTTTAAAGATTTTTTAAATAAAAAATCCCCCACAAATT +CATTTCCAAATCCGGTGGTTGCCCATCCATAAACCCGTCGTCCTCCTCCT +CATCATCACCGAACGGGTCCATTTGTATGCGATCCTCGTCTCGATATCGG +GAAAGGTTCAGAATTGGCGGCTCATCCTCTACGATGACCTCCGTCTCTGC +GTGGAGCATCGAGTCGTCGCCGGCGAAGATGGGCTCTCCGAGCTCTCCGG +CGGTGAGCTCCTCCAAATGTGGCGCTGGCTTTCTCTTTTTCGCGTTTCGA +ACCGTACTTTCCTCCGTCCTGGAGCGTTTTGGAGCTGCGATCGAGCTTGT +TGATGCAGAGGCGAGCGCTTCTTCCTTTGGGATGCCCAACTCGTAGTCTT +CATTGTTGTAGAGCACGGATTTCCGAGCATTTCGACGTGGACGAGATTTT +GTGGCTGGATCCTGGGGCTCTGCGGCAGGCTCTGGATTTTGCTGGGGCTC +TTCGGCCGGCTCTGGATTTTGCTGGGGCTCTGTTGGATTTTGCACAAGCT +CTTGATCAACTTCTTCCTGATTTTCTGCCAATTCTCCCGAATTTTCAGGA +TTCTCGGACATTTTTCTGCAATTTAATAATTGAAAATAAGAATAATTAAC +GGGGTGGAAAATTAAAAATTAAACAAGCATTAAAATAAATTTGAAAAAGT +CCTGATTTGTAGTCCGCAACGCACGCACGCAAGCATACACCAGAACAACT +AAGAGAGACGGGAGGAGAGATGGAGAATTTGAAAGAGACGGCGAGGCGAC +GAGAGAGCCGGAGGATTGAGGAAGGACAAACACACAGATGTGGGGTCTTG +CAGCGCTTTCTCTGCGTCTCTTTTTTCGACATTTTTCAATGGGAAATTTT +TTTTTGGAGTTTTTCTTTTTTTTTATCGGAAAACTTCAAAAAATTCAAAT +GGAAACGCTGTACGGACAATGCATAGAATAACACGCAAAAATGCACATTT +TTAGGCCTTAGGTTACTGTAGTGGTCTCGGCGCGAAAATGCGGATTTTCA +TTTTGAATTCAAAATAAAAAAACTGGACGTGATTTGGTACAAGCGTTTAG +TGAAAATGTTTCACAAAATAGGAGATCAATTAGATATATTTATTTATTCA +TGGAAAATGACTATTTGGAAAAAAATTGCGAAATAAATAAAACTCGATTA +AAAACAATGTGCATATGTCTTCGTTGCTTTCTTGGCGAGGGTTTCTCGGT +ATCGAGTTCTACAAGAGACACACATTACGAATAACCAAAATAGTTTAGGT +AATATACACATTGGGTGGGGGTGGGCCAGAATAATATTGAATAAGGGTGA +AGAAAAAATATTCAAAATACGTCGCTGAAGTTGGCATACAATCTTGAGTC +GGATAAATGGTAAGAAAGCAGCACCACTCAACTCAGATCACAATCTTCTG +AAGAAAAAGGGACGAATGTATAGGTTCGGAGGGGGGGGAGGGGGAAGGGG +TGGGGATGGAGGCAATTACAAATAAATCTGAAAGAAAGTTACAAATACTA +CACACCAAAACGGTGAAGACTTGCAAACGCAGTGCTTGCAAGAATTCGAT +AAAACTCGCGGATGTTAAGAGCGAATCATTTGGATTTCGGGGGCAGTAAA +TTAAATGGACAAGGCATTTCGAAAAATACACACGTTAGACTGAAAAAAAA +AAACACGATGTGATTTATGGGATGCAACACTGCTTCTTTGGTGGGTCGGA +CGCTGGCGAAGGAATGATTGTACCACTGCCACCGCCATATCCTTGTCTGT +CAGTTCCTACATGCTTGTTGGATACTGATTTGTAGATTTCCGTCAGGATA +TTAGTGAAAGCTGCTTCAACGTTGGTGCTGTCGAGGGCAGATGTTTCTGA +AAAAAAAAAATATATAAACGCAATAGATTAGTTTAACTTACCAATAAACG +ACAATTGATTTCTTTCGGCGTAGATCTTGGCCTCGTCTGTTGGAACTGCA +CGCAAATGGCGCAAGTCGCTCTTGTTTCCGACCAACATAATCACAATGTT +CTGATCGGCGTGATCACGAAGCTCCTTCAACCATCGCTCAACATTCTCGT +ACGTCACATGCTTAGCGATGTCGTAGACTAGGAGAGCTCCGACAGCCCCA +CGATAGTAAGCGGATGTGATGGCACGGTAACGTTCCTGTCCAGCAGTATC +CCAAATTTGAGCCTTCACTGTCTTGCCTTCTACCTACAAAAATAATAATT +TGAATCATAAGTGTATTCTAATGAAGTTCCTCACCGAGATGCTTCTCGTG +GCAAACTCGACTCCGATTGTTGATTTTGATTCCAAGTTGAACTCATTTCT +TGTGAAACGAGACAGGAGATTCGACTTTCCGACGCCTGAGTCTCCAATCA +GAACAACTGAAACAATTTTTCGTTTGGGAATTGAAAAATGAAAAACAAAA +TTACCCTTGAACAAGTAGTCGTATTCATCGTCACGAGAGCCCATCTTTAC +TGCTGAGCTGTAAAATGATAAAGCTTGTTTGAAAGTTGTGTATATATTGG +GACGATTGTAAAAAAGAAAAAGGGCATTGGTCACATGATTCATCAGCCGG +GCGCAATGTTTTGTTGTAAAATCGATATTAAAAGAACGAGACACTGTTTT +ATCGGCGGAGAATATTTTTATGTTCTGTTCCCGACACAAACGCGGAGTCA +GGAACCGGTTGTCTATCTCGACGGGGATTGAAAAAATATAAGTGAACTTG +ATTTAAGAATGATTCAAAGTATATGGAGTTGGGAGTTTTATATTGAATTT +TATCAATATATGAGGGTGGTTAGTCAGAAGAAAAATGTGAAAATGTATAT +AGAAGTGTGTTATGAAAGAGTATTTGAGGCTTATCATACCCGAAAAAGGG +AAGGTGAGCGGCCGAACTTTGTTTGTCGACACGATTTCGAAATAGTTGAA +CAGGATATTTTTAACAAGGGAAAGCTTTCTCTGGGTGTTCTTTTTTGATA +ATTTCAGCTAAAAATTGAAAAAAATAATTAGTTTTATGGCTGTGAACATC +CAGAATAAGCTTTTCCGAACGCGAAATGCGTGTGAAACCCATAAAATCGA +ACGTAAAACAGGTCAGGCGCACCGGCGCAGCCACGTCGGTCTGAGGGTAC +GCGACGCTAGCCGCAGCGCAAGCCTCCTCGGGTCTCGGCACGACAACTAC +CGTACCCCTTTCGCAGCGGCGCAACGGAATCTCAATTTTACATTTTTTTC +TTTTTGGCCTAACGAATTTTTCCGTTTTTTCAGAGCATTTTTCATTGATT +TTCTTAAATTTTCATCAGAATAAATTTTAGAACTAATTTCCCGTAATTCT +GATACGCGTTTTTTATAGTTTTCGTGAAGAAAATGCTGAACATTCGAAAA +ATACTGAAATAATTTAGTTTTGAAAACTTGCTCCTCTGTTTCAATATCTT +ATAATTTTCTTTTCTGATTAATATTTTGATTTTCCAGGTAATCAATCGCC +TATAATGGCTCCAACGTAAGTTTTCTTTATAAATTTATATTAGATTGAAA +TTTACTTTTAGGCCTGACTTTCAAATACTTCAATTTTGATATTAATTCTT +GGTTTTTCAGAAAGAAAGTGCCACAGGTTCCAGAAACTGTGCTCAAGCGC +AGAAAGCAGAGAGCCGATGCCCGCACCAAGGCTGCTCAACACAAGGTGAC +CGTCGCCGCTGTAAGTTTATTTAACTGTCAGAAAACAGAAAATGCTCTTC +AAAAGCACTGGTTTTAGGATCCACTATTATCCAAGCCAGCCGTCAAAACT +GAGCTATAAGAATTATCTTGTTTTTGGGTGAGGTGTATTCAATTCAGAAT +GCGTCTCAATAACACGATGACAATTCGAAATTTTAAAGTTTAAATTTTCT +TTTAGGTGTTTGAAAATTAATTTGAACTAATCCTGCATTAAAAATAAAAT +TTTTTACAGAAGAACAAGGAGAAGAAGACCCAATACTTCAAGCGTGCTGA +GAAATACGTCCAGGAGTACAGAAACGCCCAAAAGGAAGGACTCAGACTCA +AGCGCGAGGCTGAGGCCAAGGGAGACTTCTACGTTCCAGCTGAGCACAAG +GTCGCCTTCGTCGTCAGAATTCGCGGTATCAACCAGCTTCATCCAAAGCC +AAGAAAGGTGAAATTGTGTTAATGAGTTTTTTAATAACCATTCTTTGTTT +TCAGGCTCTCCAGATCCTCCGTCTTCGTCAGATCAACAACGGAGTGTTCG +TCAAGCTGAACAAGGCTACTCTTCCACTTCTCCGTATCATCGAGCCATAC +GTAGCTTGGGGTTATCCAAACAACAAGACCATCCACGATCTCCTCTACAA +GCGCGGATACGCCAAGGTTGACGGAAACCGTGTCCCAATCACCGACAACA +CCATCGTCGAGCAGAGCCTCGGTAATTTGAAAACTTATGCTTTTTAATTC +TTATTTAATTGTTTTCAGGAAAGTTCAACATCATCTGTCTTGAGGATTTG +GCCCACGAGATCGCCACCGTCGGACCACACTTCAAGGAGGCCACCAACTT +CTTGTGGCCCTTCAAGCTCAACAACCCAACTGGAGGATGGACCAAGAAGA +CCAACCACTTCGTTGAAGGAGGAGACTTCGGAAACAGAGAAGATCAAATC +AACAACCTTCTCCGAAAAATGGTCTAACTTGTTTGTTGTTCATACCTTCC +TTCCGGATAAATCGTTATTGTTTGACGTTGTTTAATTATGTGCATAAATA +ATCATGAAACGTGATCGTCTTGGCTCGACTCATCTCGCATTTCATGAAGC +GTCTCATCATTCAGATGAATCGTAAAACCGCTTTGCTGACTACTCTCCCG +AGAACAGTCACTGTTCCCTACTATGCTCCATCCTGTTTATTTCTAGAAAC +TTTTCTTCGGAGCAAGCTAATTCCCTATGAAGTGAGAGCATTTAGGTTAA +TAAACATAGTCCAGATTTAAATCCAGACAACGCAATGTTCTCTCTACAAT +GTACTCCCTCGTGAGCACCTATACCCATTGATTGATGTCGATGGGTATTT +CTTCAAAAATTTGATGGAAGGACTTGATTATCTGCTCGCCAAATATGGAA +AAGTTGGCTTAAAACTAGAATTTTAGAAAAAGCTTAAATATTCTTCCAGT +CTCTGGACTCGGGCCTGACTCCAAAAGAGCGAGCACAGGCTCTCGCATTG +AGCGCTTTGCTCGACGAGCTTACTTGGATGCTCGCCTACTCGCGAGGCCA +AGATTTCACGTGGCTCCGCGATGATCGTAAGATTATCGAAGACTTCGGGC +TTGTTCAGCTCTATTTTTGGAGGAATTGGATTGTACCGCAGATGCAGAAA +CGGGTAGATTATTGATATTTTATGGAAAAATCGATAAAATATTGATTTTT +TACTGAAAAAATTGATCAAAAATCGATTTTTTTTTCCTCGGAAAATCTGT +AAATTAGTAGTTTTTTGTTGAAACAATCGATAAAATTCTGGTTTTTCAGA +AGCAAAATCGATATATTAGGCCAAAATCACCAAAAATTATCAATTTTCCT +ATAAAATTTACCATTTTTGGCTAGATTATCGATTTTTAAGGCAAGAAAGT +CGATATTTCACAATTTTTTATTGATTTTTTTGGCTTTCCAGCGCGCAAAC +TGTGCCAAGATCTAAATTTTCCGAAATTTTCATTTCAGACACGCCGCCGA +GTGCGAGGCTACGGAATATCCGGAAAATCGGCGAGAAAGGAGGTCGCCTG +CCGAACTGAAGCAATGTTGGAGGCATTGGCCTCACTTTTGGCCTCGAATA +AATACTTTTTCGATGTCAATGAACCGTCTTGGGTAGGTGGCAGCCAAAAA +ACTCGGCCAAAACTCGGCCTTTCAGCTCGACTGCAAGGCGTTCGCCGTGC +TGGCTCAATTCAAATATACACCACTGCAGAACGAGGCCCGCGTAAAACAA +TTCATGAAGGACCGAACTCCAAATTTGGTGGGTGGCCTTGAGTTTTCTAG +GCCACGAGATTTGAAAAATTCTATAATTAGGGCATGTGGTTTCAGATGAC +ATTTGTGACGCGCATGAAAGAGGAATTCTGGTCGGATTGGTGCACCACGT +CGGAGGATTGAATTTCGTGGAAAATGCTAATTTGTTTAATGTAATATGAT +TTTGCTTCGTAGATTTTAACCTATGCTCGAATAAAATTTATATTCTAATT +TTAAAAAAATTTCAAAACAAAAAATTTCTTACGTGACAATTAAAGGGTAT +TACAATATGGGCATAAAAAATGTATTCCCTAATTTTCGAACTTGTTCAGT +CTTGGTTGCCCAGGTAATTTTTTTGCAGTTCTTGTTTGGGACTCGGAGCG +ATTTTGCGCAGATGCATCATATTTGACGCGCAGAGTTTTAATTGAGGTTT +GAGCTTGAATTGAGTTTGAATTGAATTTTAATTAAATAAAGCGAATTCTA +GAATAAAATGATGTGTTTATTGCGAAATAGATCGTGAACCTACAAAACAA +CAGACTTTACGCGCAAATTTCCGAAATTTTCCAGAAAAACCAGTCAGAAT +TTCAAATGATACTTGTTCCTCTTCTATTTCTTCTCCCAATTTTGTTGTGC +GGTGGGAAAAAGAAAAAAGCGAACAAAAATGTGAAAGAGGCGTCGAAAGT +GAACTCACTGGTTCCACCGTCGACCTCTACGGACCCGCTGAAGACTAAAG +AGAAGGAGATGAAAAAAGAAGAAGCTCCGGGAGCACCAGACGCCCCGACT +AAGCCGAAAAGTCCTCCGAAACCAGTGGTCCAGGACACGAAACTTGCTGA +AGTGCTGCCTGAAAGTGAGAAGGAAGACGAAATGAAGAATGGTATTCAGT +TGCCGAATCCGCCGAAAAATTTGGTGGGTCTCACGGCGATTTGAGTGTTT +TATCGATTTTCTATGAAATAATTGATTTTTTCTAAAATTATTGAGATCTA +GATTTGCGAGTTTTCTGAATTTTCTAATATATCGATTTTTCAGAAATGCG +AAAGTGAAATTGCTCCAAAGGAAAAGCCGGCGGCTGACGAAAAGAAGGAC +GAGAAAAAAGATGAAAGCAAGAAGGATAAGAAGGAAGAGAAAAAGGAGGA +GAAAAAAAAGGAAAATGACGAAATTATGTGAAAAATTCGATAAATTGGTT +CTTGAAGATTATTGATTTTTCATTGTCGATTTTTCAGAATTCCTCGAAAT +TTATTTGCGCGTCATATATGGTGCATTGAGTCCATAGAGACTTCAAAGTT +CACGCGCAAATGCAGACATTTTTGCACGCGCTGCGGTGAAATTCCTCTTG +GCGAATTCAAATATTTTTTCCCGCCTTTTTTGAAAATTTTCGAGGCGTTG +GTCGAGCTGAATACACGTGAAGTTTAGACTGAATGTCAAATCACAAATAC +ATCACATTTGACGCGCAAAAAATTCGTTTTGAAAATTTGCGCGTCAAATA +GGGTGCATTGAGTACGCGGAGCCAATACATCACACTTGCTTTTCGTGGAA +AATGGAGCGAAATTTGATTTTTTGATTTAAATATTACGGGAACAGAAAAT +TCTGAGAATGCGTATTGTGCAACATAATTGACGCGCAAAATATCTCGTAG +CGAAAACTACAGTAATTCTTTAAATGACTACAGTAGCGCTTGTGTCGATT +TACGGGCTTGATTTTTTTTCCATTTTCTTCAGTTTTTCTGACATTATTGT +GTTTTATTTTAATATTTTTACCGATTAATAAATGATTTCCGTAAATCGAC +ACAAACGCTACAGTAGTCATTTAAAGAATTACTGTAGTTTTCGCTGCGAG +ATATTTTGCGCGTCAAATATGTTGTGCAATACGCATTCTCAGAATTTTGT +GGCCACGTAATATTTGCGTTAAATAAAAATCAAAAAATTAAAAAAAAAAA +AACATTTCAGAAATTTTCAAAAATTTTTTGAAAAATTGACGCACAAAGTC +TCCTGTTTCCCTTTTCCCCAAAGTTTTAAACTAATAAAACTTTTTTAATT +GTCGAATCCGACCAGTTATTTAATACGAGACAAAACGGAAACAAAGATTC +CAATTTCCGATTACGGTCAGCTCAACACTTTCGCTCAAGGAATTCTCTAC +GCTTAGATTTTGATCTTAATGGAAAACTGGTAGAACTTGGTATAAAACTA +TCCAAAAAACTGGCAGAAAGAGTAGTCTTTCCGAAGAAATGAAGTCCCTA +ATCGAGGAAGATGACTTGGAAGTCGGCAGATTCCGCCGCAACGCGTTTTC +CGCCGTCGCCCTCTCCACCTCCTGTATTCTGGCGATTGTGGTGTTAACAC +CAATTGCCTATCAGGCAATTCAGAGAATTCACTCAAATTTGCTTAACGAT +GCCCATTTTTGTCAGGTAATTTTTTTAAAAAATTTAGAAATTTTGATTTG +GAAATATTCAAATAAAAAAAAAGTTTTTCGAAATTTATTTTCAATCGTTT +GAGATTTTGACATACATTCCAAAAATTCCTACTCTTCGCAATTTTTTAGT +CAACTCAAACTCAAAACCTTAAAAAAAAACCGCAAACCTGTCATGGCGCA +TCGATGTTATCCCTACGCTAAATGTTCTGTTTTCGAAGGTTACTTTTTTC +CAATTTTTATCACCAAGGAAAATGTATACACAAAAATATATAGAATTTGA +CGTGCAAATTGGCAAAAAACTAAACTTGCGCGTAAAATCACTGCATTGCC +TCTGCGGACTCAACACACCAGATTTGAAATTTCAGGAACTTATCGATTTT +TGTAAAATTTTGCAGCATGGCGCATCGATTAAATATTAAAAAAAAATTGA +AAATTATCGATTTTTTTGAACACGAACAATTTGTGGAAAATATGAAATAA +AAAAAAACATGGTGCATCGAAAAACTTACAGGCTCGAAACCGTGACCTCT +GGACAGAAACAATGAAGATGGCTCGGAGCCGCGGCCGGGACGAGGAGCTC +GTGGCCCGAACCAAGCGAGCGGTTAAAGGCACATGGCTCTTCGGACAGTA +TATTCCAGACCGATCAAGCAGAAATCGACGACAGCAATACGCCGAGGCCG +CTGGCGGAGGCGGTGGAGCACCACATGCCGAGTGTAGACGGGGTCCACCG +GGACCACCGGGTGATGGTAGGTTTTTAGATTTGCGAGGCAATTGTGGTGT +ATTGGTTTAATTTTACAGACGGGGTCGACGGAACGGACGGAAAAGACGGT +GCACCTGGAACCGATGGAAAAGACGGTCAGGTACCACAAGGACCAGCCGA +CGGAGGTTATCAAGAGGGACCATCTGATGCAGTTGAAGCATGCACACGTG +AATGCCCACCAGGACCGCCTGGACCAACTGGAGCGCCCGGAGACAAAGGA +TCTCGAGGCTACCCTGGAGAATCTGGAGAGCCAGGCACCCCGGGAAGCGC +CGGACCGAAAGGAAATGCTGGACCGTAAGTGGAACTAAAGAATCGATAGT +TTTCGGTAAAAAATCAATCATTTTAGGAAAAAAATCGATAATTTTCATTT +TCATTTTTCTCCATTAAATTATGTTAACTTTCTAGAGCTGGACCACCAGG +ACCACCCGGATATCCAGGACGTCCTGGAGAAACCGGAGATCACGGAAAGA +CGATCGCCGGAGAGGCGCCACCTGGACCACCAGGACGACAAGGAGAAATG +GGTCCACAAGGACCACCGGGACCACCAGGGCCACGTGGAAAGGACGGAGC +CGGTGGAGAGAAGGGTGCTCCGGGAGATCAAGGTAATCCGGGACCATATG +GAAAACCTGGGCAACCGGGAGCTCCAGGACCCGATGGCTCTGCTGGTGAG +AAGGGAGGATGCGATCATTGCCCACCGCCAAGAACTCCACCTGGTTATTA +AAGATTCTTCGATTGATATTTTATTTTATTTTCATGACGTTATTCATTTT +GTCATTCGGTTTTCTTTTGTTGCAATATGATAATAAATCAGATTCTCTTG +CCAGTAGTTCCAAGTGCCCCAACATATTTTTGAGTCCTTTATGTAGATCC +CTCTCCTCGAAAGCTGGATGATTTAATAAATCTTTCAGAAAAATCGAAAA +TTTTAGAAAAAAAAACATCAAAATTTTTGACAAACTGCATAATCAGTCAA +TATTCTAAAAAAAAATACGATCGCACAAAAATAAACAACGACGCAACGAC +ACTCCGCGGTTACTAAGCTCCGCCCACGATTTCATTTGCACTGCGTTGAG +TCGGCCGTATTGTTATTCAAACATGAATGAATATACTGGTGAAGTTTAAA +AAATTGGGTGTTTAGTTTTGAAGAAAATAATTTTTTTGGAATTTTGAATA +AAGCACAATTGGCAGCTGAAACTGGACTTTCAGACAAATTTTGAACGGTG +GTTGTTGATGCTTTGAGTTTATATTGTTATTCAAACATGTATGAACTTGT +AAAGTGCTTGTAAAACTTGTAAGTTGCTTGTTCGCTCATTCTGAAATAAA +ATTTAAATTAAATAAAAGTTCACGTGATACAAAAAAGCCAACTTATTGAT +TGAAATCGATAAAATCGATAAGAAATTCATTCATTTAATAGTTTTTAACA +AACAACAAATGCGATCAAAAAGTTCGGAAGGTGATTTACAACCAGAGGAC +ACCCAATCCAGAGAAGATAAAGAGACGACTGCTACGTATAGTGAGGATAC +AAAGCCAGGTAAATACAGTAGTCCTACCTTAAAATTACAGTAACCCAGCT +GACTAAATATCATAATAAAACTTGCAAAAAAATGATGTAAAATCTTAGTT +TTTAGTCTTTTGAACTGGTAGAAACTGTGTTAGCGCCACTTTTTGACTCT +AAATAGAAAAATTTCCCATTTTAAAAGAGTTGTATTATGATACACTGCGT +GGCGTGTAAAATACCAAAAAATAAGCGCGGTTTTTTTTTTCGTAAAATCA +CAGGGAAAAATCCGAAATCGGAACTCCAATCAGCCGCCAACATCCCACGG +GCCCAATAACTTCTGGGTTTTGTTTCAACAATCTCATTTACTCCAATTCC +AGAAACCCAAAAGGAGAGAAACGCGGCACTGGACAATCTTGCCAAGACCC +CAATCCAGTTAGTCGTCCAACCAACTCCTCTCACACCAGCCATCACGCCA +TGCGAAGCACCACCACCACCACCTCCACCAAAACCCTCTAGCGATAATAA +CAACTCGAAACGATTGAAAGTGAAAGATCAACTGATTGAAGTGCCCAGCG +ATGAAGTAGGCCGAGTTGAGAATAATATAGACAATTTCCCGTTCTATCAT +GGATTCATGGGAAGGAACGAGTGTGAGGCGATGTTGAGCAATCATGGAGA +CTTTTTGATTCGAATGACGGAAATTGGGAAGAGGGTCGCCTATGTGATTA +GTATCAAGTGGAAGTATCAAAATATTCATGTTCTAGTGAAACGGACCAAG +ACGGTGAGAGTTGTTTGGTATTATCATTTAGTTTCGTTTCAAATCAGACC +GAGATACATACAAATATTGAAGTTCAAATTTAGAACATGTTGCATCGCAA +TGTGTTCATTGTGCTCCCTGAAGCATTATGCGGACATCACGAATTACATA +AATTATTTTAACCAATGGTGGGCGGCAAATTGACAAATTGCCGATTTGCC +GAATTTGCCAAAAATTTTCGGAAAATTGTATTTTTGCACATTTTTTTTAA +ATTTCAAAATTTCAAATTTTATCGGCAAAATTGTATGCATCCTATGAATA +TTTCTACATCTGTTTCGAAAAGTAAGCAAATTATATGAAAATATCTAAAG +AAAAGGGGAAAAAATTCGAAAAGGCACAGTTTTCAGTGTTTCCGTCTTAC +AAAAAAAACCTCGAAAAACTTTCGGCAAATAAGCAAACCGGCAAATTGCC +GGAAATTATAGTTTCAGGCAAATCGGCAAACCGGCTATTTGCCGAATTTG +CCGAACGGCAGTAGCCTCTCACCCCTGATTTGAACATGGTGCATTGCATC +ACCGCTCCTCGACTTGGAAAGTTTATATCGGTAGATATTTGCAGCAGATG +TAATTTACTGATATTTTCAGAAAAAGCTCTACTGGACCAAAAAGTACGCC +TTCAAATCCATCTGTGAGCTTATTGCCTATCACAAGCGAAATCACAAGCC +GATTTATGAGGGCATGACGTTGATCTGTGGCCTGGCACGACATGGATGGC +AGCTGAACAACGAGCAGGTCACATTGAATAAGAAGTTGGGAGAGGGACAG +TTTGGAGAAGTGCACAAAGGATCGCTGAAGACATCTGTATTTGCAGCCCC +GGTCACTGTTGCCGTGAAGACCTTGCACCAGAACCATCTATCCGCCAATG +AGAAGATCTTGTTCCTAAGAGAGGCCAATGTGATGCTCACCCTGTCTCAT +GTAAGCTACCTGTTTCAAGTTGAACTAAACTAAAATTAATTTCAGCCAAA +TGTGATAAAATTCTACGGAGTATGCACCATGAAGGAGCCCATCATGATTG +TCATGGAGTTTTGCGACGGGAAATCCCTGGAGGACGCTCTACTCTCCAAG +GAAGAAAAAGTGTCAGCTGAGGACAAGATTCTCTACCTTTTCCACGCCGC +CTGCGGTATTGATTATTTGCACGGAAAGCAGGTTATTCACAGGGATATTG +CGGCGAGAAATTGTTTGTTGAATTCCAAAAAGATCGTGAGTTTGTTTTTC +AAAAATTTCTGAATCTATGTGAATGAAAAAATAAATTTCAGCTGAAAATC +TCCGACTTTGGATTGTCGGTCAAAGGAGTTGCTATAAAGGAGCGAAAGGG +AGGATGTCTGCCGGTCAAGTACATGGCTCCGGAGACATTGAAGAAGGGGT +TGTACAGTACTGCCTCTGATATTTATAGGTGAGCCTACGAGCATACATAG +ACATTGGTAGTGGCGTCAGCGGTGGCCTAGAAACCTTATCCGCGTCTGAA +GGTTAATCAACCTCACACAAGTCTCTATGATTTCCAGCTACGGCGCTCTA +ATGTACGAAGTCTACACGGACGGAAAGACGCCATTCGAAACGTGCGGGCT +ACGTGGAAATGAGCTCCGAAAAGCGATCATCGGGAAGAGAATCAGCTTGG +CCGTTGAGGTAGAGCTACCAGTGTTCATTGCCAACATTTTCGAGCAAAGC +AGGCAGTACGAGACCGAAGATCGCATAAGCTCCAAGCAAATTATTCAGAT +TTTTAAGGAGGTTTGTGAAGCATTTTATCGGTTTTTTGTTCAAAAAATTA +GTAATTTTCCAGGAAGTCGGATTCCATGAAATTGAGACAAGTGGGATACT +GCATAAGCTTGTCAATTCTCTTCCGAGAATTCACAATAAGGAAAGAAAAC +CCGCGGCGGTGGCAGTGTAATAAATATCTGAAAATCCCCCCACCCCTGAA +AATATTTGACTGTATTTTTTAAATCAAACACACAACGCACACAAACAGAC +AGACAGAAAGCCTAAGTACACAGAGAAAATGTTTGAGGTGAGGTGCGAAA +GGGAGGAGGCTAGAACACCTACTTTACGCCAACAAGTTATGACTTTTTGG +AATTCAAAATGTCGTTTTTTGCTAGTTCACTGCTTACCTACAAACCTTCC +TACCTTGTCTGCCTACCTTCCTTCCTATTCTCTTATTGCAAGATCTTTTG +AATTTTTCTGAAACGTCTGTCTACTTCTGCGTCATTTGCAAACAGGCTGT +TCTCAGTTTTAGGGGGTGGCAGCACCCACAAAAAAACATTGGAACAGAAA +TCAGTCGGAGTGATCTACTAGATTAGATAAACATTAGATATCAGTTTGGA +AAAGTTAAACATTATTAACTCACAATGGATTTTCTTATTGTGTTTCTTGA +TATAAAGCGTTGAGCGGTATTGATACCATTACAATGCACTAAGCTAAAGG +CTGTCAGAGCCGAATGAAAAACATGATACATCGAGCATGCGGCAATTGGC +GTTCGGAAAATCGGCAAATTAAGATTTGCCGGAAATGTTTTGAGGGATTT +TTTATAAGATTTAAATGTGCCTTTTTGAAATTGTGTCCCGTTTTCTTTAG +ATATTTTTATAGGATTCGCTCACTTTTCAAAATAGACGTAGGAGAATTCA +TAGGATGCATACACTTTTGCCGATTGAAATTTAAATTCTGAAATTTCCAA +TAAAAGTGCATCACCACAATTTGCCGACTTTTGGCAATTGCCGTTTCTCC +GGCAAATTCGACAAACCGGCAATTTGCCGATTTGTCGATTTGCCAGAAAT +TTTCAATTCCGGCAATTTTTCGATTTGCCAATTTGCCGAGAATTTCAATT +CCGTCAATTTGCCATATTGCCGGAAAAAATCGTTTGCCGCCCATCCCTGG +TTCGAACTCCTAGAATGGTAGAATATGAGTATACTAAAAATAATTTGAAC +AGAACTGGAACTGGAAGAAAAATTTTTTACCGACGTCTTCTGAGAAAATT +TCGTGAAAATTGAGTTTTTATCACTTTCTGACTCACAATAAAAAAAATTT +CCAAAATTTTTTGAATAGTTCTCGATCGTTTCCAAACTGGTCTTCCGACA +TTCAGGTGCGTGATTGGTAAATATGAGGGAACTGCCATAATCAAATGAAA +AACACGGTGTATCGTCTGAGAAAACCTTAAACTGTTCCGTTTTAGTAATT +GGACAAGGATCTGCTGAATCTCGCTACTATAGCAACCGACATCTTGCGGG +TCCAAAAAAGATTGATCTTGAAAATTTGATCCAAGTTTATTTAATCGCCG +CCACACACACACTCACAAAAAAATCAATCAAATCACCCATATCAGTTGCG +CGATTTCTAGTTTCTAGGCGCGAAAATCAAAAGGAGGAGAAGAAGCATTT +CCGCATTACTCGTGTGTGTGCCGTTTCCGTTTATTTGTCCCTCAGGCTCC +CCTCTCTGTTTTTTTTGTTTGCGAAAACTGTCTCTCTCTCTCTCTCTCCA +TCACTTTTCTGTTGCGGAATAGAGGGAGAGAGAGAGAATTTCGGAGGGAA +AAATACCTGAAATGTGATCCTCTCTCTGTATGTCATTGACTGTTGCGCGA +GAGCCTTTTCCCGCGCGCGCGAGCCTCCCACCTACCCGTCGACGAGCCTA +TTTTCTTGTCGGCGGTGCCATTCGGCAATACACGTCCCTCTCTCTTCTTG +CTCTAGAAACATTCGGATTTTGATTTTTTGATTTTTCATGGTGGATCTGT +AGGCTTTTTTAGGCCATCTTGGACTTTGTGGTGGCCTAATATATGGTGTA +TTTTCCAATTTATCATATTTGCTTTAGTATTGTCCGACTTGTAGGCAAAT +TGCACCATTTTAAGCCAAGTAATAAAGCTTTGAAGTTTGGCTGCCTAGGT +TTTTCTAGCCACCAAACAATTTTTTTGTTTTCACAGCACACTTTTTTAAA +GACTGTCATAAGTTTTCAAAATTCTTTGAAAAATTTTACACCGAATTTTG +AGATCTTTAAGTTTGGTGGCCTAAATTTTTCAAAATTTTCTATGCCACCA +GACTGAAACGTCCTAACTCTATTTGAATTATCTTTGAAACTATGAAAACT +ACAAGTTCGACTAAATATGGCTTATCCAATTAAACTCGATTGGTGGCCTA +GAAAACCAATTTCGATTTATTTCATTTTCTAGGCCACCAATAATCTTGTT +CGAAAATTACTTTTATTTAATTACAGTGGAGTTTGGAATACTTACTGCCA +TGGGCTGTAAGATGTTGCTCGCCTAACTTTTTCTATGCCAGCAACCAAAA +AGTGGTGTTGGTGGCCGACAAACCCAAACTTGGACAATTGCATTTTCTAG +GCCATCATTTTTTTTAAACTAATCGTTGTTGGTTTAGTCTACTGTAAAAA +ATCAAATCGATAAGAACATTGGGAGCCAAGCTTTGGAGTTGGTGGCCTAG +ATTTTTCTAGGTCACTAACTTGAAATGTCTGTAACTCTAAAAAATAATTT +AGAGATATATAACAGAATTAGTAGGCTAATTTTAGGATGAGAAACTATTT +AAACAATTGGTGGACTAGAAACTGAATTTTGAAATTTCTAGGCCACCAAT +TCCAAATAAGCCTATTTCACTCCTGAATTGAGATAAAACGCTGAAATTTT +GGACATATTAGAATACGCTATATTTGAAAAAATGGAATTGGTGACCTAGA +AAATATTTTTTTGAAATTTCTGCTCCACCAATTTCAATTATAGCATAACT +CATTTCATAGTTGTAGGACGGTGATTGAAATTTAGGATAGACAGATTTTA +AACCAAAACAGATTGATGGCCCTTGAAATTTCTAGGCCACCTCTCCAGAA +AAAAATCTGAAAATTGTTTTTATTTCTAATTCATTTTCTTCGTCCGTTTT +TCATCTCTCGAGGATCTTATCCCCTTGTCTTACGTCTCCCACCCGCTGCT +ATTTGGGCGACCTTCATAACTGTGAAAATTCTCACCATTCTCCCTCTCTC +GTTTTTGCCCCCCCCCCCCGGTCTCCTATCATTGTTCAAGTACACCTGTT +GTCCCATAACATCTGCCAACCAATTTTTTCCAATTTTGCCACAATTTTTA +TTCAAAAAAGTGCATTGCAGCGGCAGGCATGCCTCACTCGTACACACACT +TGAGCATACAGGAAAAGCGAAAAAATCAGTGATTGTTTGGATTCCTGGCT +CTTTCTAGGAAAAAAACTCTTCCATTTTTGTAGTGCACATCAAAATGATC +AAGCTGGTTAATTTTCAAGTGACTCCCAAAAAAATAACTGAGAAAGTTGC +GTTTTAAAGTTTCTAGGCCATTGTGGGATTTCTAGGTAGGTTTTTGAAAA +TAGAAGACAGTCTTGCACTAAAGTTTTGATTAGGCTGTTAAATGATTTTT +GTCAGTACGTTTTTTGGAACTTCGATTTTTGCCAAAAATTCCTTTTTTAG +TTTTTGTTTCAGTTTTTTGCAAATTTTTATTTCTTCCATATCTTACAACA +TTTAGAAGGTCTCAAAGTCTCTGATAGCCAAGAATTGACTCTAATGACGT +TATGAGCTCCGAGACTATTTTAACCTTTTTCCCTTTTAAGCATAAAATAT +ATAAATATCAAAAATTTAATACAAAAACTTCTCGTTTCGAAACGTTTCGA +AATCCTCCAGTTAAAAAAAAATTAGATTACGGCATCGGAAAAATTGCGAA +ACTTTTGAATCTGAGGGATTTTCAATAGAGGGTCCCGCCAGGAATTTGAG +TTTTTAACAGTACCCTTTCCATCGTCCTTCCCGAAGCCCATTACATCATC +ATTAATTTTGCGACCTTTCTAAAAGCGGTCATGGGGGGGGGGACATGTGT +TTGTTGCATATACAGGGACCCCCCGCCACAACCACCGCAACTAGAGATAA +AGATCTGCTGCACACAGACAGCTGGCACATGGATGGACAGAATGTCTCCT +TAATTTTACCGCCTATTTCATAATAATAAAAGTAGAACGGGGGGCAGAAA +AGAGAATGATTGCGAAACCACCTGCTTGGCTGTCAGCGCATAAACTTTTC +GGAAATTTTGGGTCCCACCACGCTTTTTTCGGTAACAAATTTTGAGATTT +CTCGATACACCATGATGTCTTTTGGTGGAATTTTGGGTTATCATGGCTAA +TACAAAGCTTTAACGTGCCTTGAACTTTCGCAATTTGAACTTTTGGCCTT +TACTTAAAAATTTCGATGGGGCTCTATAAGCCATGTGGTTTCGAACTTTT +CCTGAAAATTTAGATTTTTGTTCATGCACCATGTTGTTTTTTTTTTGGAA +TAATTGAGGAATTCCTTACTTTTAAAGTAAAAAGTTTGGTGAGATCCATG +TGTTTTCATATTATTCAGTTGGTAAATTATACAGATTATTGACTGAAGGT +TAATTTTTTGTTGGGAAAATAAAAATCGCCAAAATCAATAAAATCGTATT +TAGAAGTAGGGTTTCCATATAGGCGGTAAAAGGCTTGTCTGCCTGACAAT +AAGACGACCGCCGCTCGCCTCAATCCGCGGCGGAGGCAGGCAGGGTTCAG +GTAGGCACTGAAACCGCGCCTGCTTACCATGATGTTCCGTTCTTGTCGAT +GCACCATGATAATTTTGGGTTACATTTTGAGCCTTTTCGAAAAATTAATG +GTGGAAAATTTCAAGCTGAATTTTAATATTTATTTTTTTAACCGTATTGT +GGGACATGCAAATGTCTTTCATTTTGTGTCCCTTCACTCTAACGTCTTCA +GAATTTTCGAACTTCTCGATGCACCATAATGCTGTTTGGCGATAACTTTA +GAGTAAGAATGGTAGCGATTTTTGCGATGCACCATGACGTTTTTATCGAT +TTTCAGAAAAAAAATCACTCCGAGACCCAAATAGTTTCATTCTCGACGCA +CTATAACGTTTTCGAAGTAAATTTCAAAATTGCTTCTCGGAAAAGTTTTT +TGAGACCTACATGCACCTTTAATCTTCTTTGGAAACTTTGGAATTTCCGC +CGAATACTCTCATTTCAGTTGTTCTCGATGCACCATGATGGTATTTTTTT +CAAATTACTTTTTTTTGATTTTTCCATGAGAGGACCAATATCTGTCTTTA +TAACGGCGCATTCTGTAACCAAATTTTGAAATTCCACGACATTCTGCTCT +CATCGATTCAACATGATAATTTTAAAATGAAATTTAGCGATTTTTCGGGA +AAAAAACAGTTTCGAGATTTTCTAGTTATTGGACACTCTGCACCTTGCTT +ATTTGGAAATTACATTTTAAACCGACAACCCTTCAAAAACTGCTTTTCGT +CGATGCACTATGAGTGCATAATTTTGTGTAAATCGTGGTGGGCCTCTAAA +AAAACCGAAAAAAAAAACGTATAAAACGCAAACAAATTGTTTTTGTTGTA +ATGTTGACACCAACAGATTCGGCGTGGAATATACGGAAGATCGGATTTCC +AAAAAAACAACCGCTCTCCTGTTTTCGACGTTCCGCCGCTTTTTATGGGA +GAAGTAGTATGTACCTTTAAGGGTACTGTAGCCCCTTGAATATTGGCCTA +AAAGTGAAACTAGTGTTGCCAAAAAAAAACGAGATGACCAGTTTCAATAT +GTCATTTACATCTACACATTTCTAAAATCTCATTTTAAATTCCATTGTTT +TCTCGTTTCTTCTGTCCCAAAGTACCGTATCCTCATCCTTCTACCACCTT +AATTTGCATTTCTTCTTCCTTATTCACTCTTCTTCCCCTGGACGAAAAAT +GTTGCACGACAACAACAAAAGAGACCCGCCCCCCACCATCGGTTTCTCTG +AACCTCTAACTGTCCCCGCCCCCTTTTGGGAGCCCACTGTCTTTTCTTTT +TTTCTTTGGTCGCTGATTATGACGGATCGTTTTTGTCGTTTTTGTATTAC +AGGAATACAAATTTCCCAAAACGCGTATTGCACAACATATTTGACGTGCA +AAATATCTAGTAGCGAAAACTATAGTAACTCTTTAAATGACTTTTGTAGC +ACTGATGCCGATTTAATTAAATTATTTATTAACAGATAAAATATTAAAAG +AAAACACGACAATTCAAAAAAATTCATTTCGTAAATCGAGCCCGTAAATC +GACACAAGCGCTACAGTAGTCATTTAAAGAATTACTGTTTTTTCGCTACG +AGATATTTTGTGCGTCAAATATGTTGCGCAATACGCATTCTTATAATTTT +GTGTACCCGTAGTATATTTTTGTCTCTCTGATTTCCATTGCAATTTTTTA +ATTCCATATTTTTTTGGTGACAAATTTCTCCGCTTATCAATTTTTTTTTC +AACCACATAATTATTAACCCCAAAACATCGCAGATTTTCAGGTAAAATGC +CAGTCGTGAGCGTTAGACCTTTTTCTATGAGAAATGGTGAGCAATTTTTT +TGAAGTTTTTTTTTGAAATTTTTAATTTTTCCAGAAGGCTTCTCAAACGG +GCATAACACGTGGAACGACGCCGAATTTTGGAAACCGTGAGTTTTCGGCA +AATAAGCTAACAGTCTAAGAAACACGAAAAAAAATCCAATTTTCTTTTCA +AAATTCGTGATTTTCGGATGATTTTTGAACTTTTTGATTAATGTTCCCAC +TGAAAATCCTCCAAATCTCTAAAAATCCGCTTCTAAAAAAGCCTCAAATG +GCCTTGCGAGAATAGACGGAATGTTCAAGGATGACTGGTATAAAATCGGC +AAACGTGTTGCCATTCAAACAGAATATCTCGAAATTTCGCCTTCCTTTTT +TTTAAGTGGGTCGGATATTTAACATACAGAAGAGAATAGGGAGAGAAAAG +AGGGAAAAGAGGGGAAAAGTCTTCTTGGAAACAACCTCGAACCGCAATTA +AGTTTTTGCCTCACCCTTCAATTTTCGTGAGAAAGTTAAAAATCCAAATT +TTTTTCTCCTTTTTTAAAAAAAGATTTCCTCCTCAAAAATTCAAAGGATC +GAATTTTTTGTTACACGCCTGCCTCCTTTTTATTACCCTTGTTCTTGATC +GCAACCTCTTTTCTAGATTACTTGAAAAAATGCGCTATTTTTTTTCCTTT +TTCAACAGAGTCAATTTCAAAGGTGCTGTGGAAAAAGTTTCGGTTTTTTT +TTGCAAAAATAATCGAAATTTGTTCGTTTATACTGCTTAAAAAATGACCA +AAATTTCAAGTAATTCATTCGAAAAATCGATTTTTTTGAAATATACAAAA +ATTTTCAATTTTTCATATCTGAAAACACAATTTTTTCGATTTTTCATTTT +TCTTGGAAAAAACACAAAAAAAAACTGTATTTAATTTCCCACTTAATACT +ACGATATCCAAGCCCCGCCTCCGCGTATTGTACGTGAACACGGCGGCCCA +AAATTACACACTATCTCACACACGTTAAATGAGTGATACCGTACTCTCTC +TGTTTTTTCTTTCATTTTTTCGGCGCCGAAAATTTTCAATTTTTGGTGGT +TCTTTTGGCGGGATTTTTCGGATTTTTGTCGCGTTCACACACACACACCA +GTTGGTGTTGCCTGTCGTCACCCACCCGCCCCACTCTTTGTCCGTGTACT +GCTTTGCCATTTGTGCGCGCGTACCGCTGCCCGTCTGTCTTTCTCATCAT +ATGCGCCTCGTTTTGTCGCTTTTTCTCCATTTGCCCTTCCTACATGGGTA +CCTGCGGTTTTCATCGAAAATATCCTTAAAAATTCCGAAAAACCTCTATT +TTTCGATTTTTGAATCGATTTTCGCCCAAACATAACCATTTTTCAGAATG +AAGGAAGAACAAATCGCCTATAAATTGCCAGGGGCTTGGTATTACGAGGA +GGACACTGCCTCGTGCTCTCCAGTCAGCGATCCGGAGGATATTGCGCAGT +TTCTCAACTACAGAACGTCGATAGGCGTGCAAAATGTCACAGAGTCCGTG +GAAGTTCCGACGTCGGAGCATGTCGCCGAGATTGTTGGTCGTCAAGGTAA +AAATTGCCTTTTTAGTCAAATCTACAGTTTCCACAAATTTTCAGGCTGCA +AAATTAAGGCACTGCGCGCCAAGACCAACACCTACATCAAGACACCGGTT +CGCGGAGAAGATCCAATTTTCGTGGTCACCGGACGCCTGGAGGACGTGAA +CGAGGCGAAACGAGAGATCGACTGCGCCGCCGAGCACTTCACACAGATCC +GTGCGTCGAGAAGACATACACAAGGTAGGTGACCGTAGGCAGCCGGTTCC +TGAGCGCCTTGTTCAGTTGTTCCAGGAGCCCATGCACCTGGACAGATCAC +GAGCTATGTCAGAGTTCCGTTAAGAGTTGTCGGACTCGTCGTCGGACCGA +AAGGAGCGACTATCAAGCGAATTCAACAGGACACCCACACGTACATCATT +ACGCCGAGCCGAGAAAGGGAGCCCGTTTTTGAGGTAATTTTGTTGGAGAG +CATAGAGTTTTGGAGCAAAATTCTCAGCAATTTCATGCTTTTTAACAAAA +ACAGAGAAGTTTCTAGTTTCGGCTTAGAAAATACTGAAAATCGGCTTTTC +CATGGCATATATCGTGCTGAAAATCTACTTTTGACTGAAAAATTCAAGTT +TATGACTAAGAAAAGTTAGATAATTAGACCATGCTATTATTTCATAATAT +TGGTCCAATTTTTGTTGCTTTGCTGAAAATTAACAAAATTTAAAAATCGG +CGGGGTTTCTGAAATATTTCTGTATAAAAACCGATTTCAACTCCAATTTT +CCTCGATTTTTACATATAAGTAATCTAGAAAAATTGTAAAATGGGGAGAA +TTCATAAGAAAATCGGCTGTTTTGTAGCAAAGTTTGTAAATATATCATTC +TGAAAGTCTCAGCGATAACCGTGATTCTAGAAAACCTCATCAGGATTTGA +TTTCTGCGACACACTTCTCTCGAGTTTTACATAGAAGTTGTTCATTACAA +ATTTCTATTTTTAAGGTCCCCATTACCATTGTCAATCTTTCATTCCGATT +ATTTGTTTTTCCTCGTCACTGCAAGAAGGGGAGCCTAATGCCTAGACAGA +GACAGAAAACACATGTGTGTTTGTAAGTGTCTGGTGTGATATACCCAATT +CTTTTCGGCCGTCTCTTGTTTTCTTCCTGACACCGAGTTTCGAGCGATTT +TCGAGGTCGTACAGTTGTGAATTGGCTGCCACTGCTGTGGCAAACAAACA +AAAACAATCAAACTTGTGCGGAATTGATATTCTAAAGAGAATAAAGAGCA +ACCATGGGCGCCGAAACGAGCAGCGGAAGGGCTTGTGACCTCTTGGTGTG +AATTTTAAACGGTTTCCTTCCATCCGAAATGCTAAAAATTCCTCGGGAGC +CGTTTAGGGTCTTCACTGAGAGATGATGATTAGAATCTTTTAATTTGGTA +GAATTCCCCCCGCGGGACCGATTAATGTTGCATGTCGTCTTCTTCTTCTT +GGCAGCAAAATATCATTGTTGATGAGATATCTCAGTTTGATGCTCAATGA +CGCCTTGAGAAACATCCAGCACACAGTAGATTAGTCGAATTACCGATGGA +TGGGGCCGCCCGGGTTTTTGGAGCCAAGAGTCACGCGATGGGGAGTCCAC +ATACACACGCACCAACTCTTTCATTCCATCTAACAGGGTAGTAGGGTGAA +GAAAAGGGGGGGGATCGCGATGACAAAGAGACTCAATTAATTAAATGACC +GGGGCGGGCGCCAAATTGCACATATGCTTGGTTTTATTGCACCGTTGGCT +CAGGGAGAGCAACATTTTGTGGCAGCACCAGGGGTACTTCAAAATGACGA +ACAAAGGTCGTTGTTGTTTCTATAGGAAGGCTTCCGAACTTTTGAACAGT +AATCAGATCATATTAGGGTTATGTAATTGACGGTTTTGACCGTATGTGTC +TATAGATGCGTGTGTGTGTGTGTGTGTGGCGACATAAATTACCGTATCCG +CATGGCCTTTTTCCTCCTTCCTCACAATGGTAATTATCATCCCCCACTAC +TCTGGGTCGCCGGACGAACTGTGAATGTGTTGACAGTGCGGGCCCACTAG +TACATGACATCTTGCCCCGGTGCGGTGCGCTCATCGTTATTCCTCCCAAT +TTAGTTGTCCGTTTGACACAAATGCCTCCGGTACCCTGGACGAGACAAGG +AGGTGATGGATTTGCCAGGCGGGGAAGGAATTACATGATGTTTGGGAGAA +TATGAGGGAAAGGTACAGAAGCTTCACCTCGGATATTATATGCGTTCTAA +AAAGACCAATTGTCGTTTTTGTTCGTGGCTCAAATGAATAATTGGTATGG +AAATATAGAAAAATGTCCGACTAGTTTGGTAATAGAATTGTTTCGTTTTG +AACATTTCAAAAATACCTCAAATAGTGCACTTGAGATCTTTGTTGAATTT +TCAAAGGTTTTATTTTCAGATAAATTGAGCATTTTCCATACTTATAAAAT +CAATTTTTGGTTCAAAAACTTCTAATTTTCTCACCGAAAAAGTTCTCACA +AGACAGTGACAGAGGTCGCGTGTCGTTTTGATATCCATCTCGATAATCAG +AGATTGTGATCTATGCCTCAATGACACAGTTCCGCGAAGGAGTCCGAGAA +AAACGTACAAAATTGGGGAAAAATATTGGAAATAACATTTATTGAAAAAT +TAAAAAAAAAACATAAACTATTTAAATTCACAAAAATTCGGAAGCATATT +TCCTATAATGAAAACAAAAAATTCTGAAAATGTGTACTGCACAACATATT +TGACGCGCATAATCTCTTGTAGCAAAAACTACAGTAATTCATAAAATTGA +CTACTGTAGCGCTTGTTTTGAGTTACGTGCTCTACGAAATGAATTTAAAT +AATTTATCGATGGAAAAATAATTTTAAGCAGAAAATGAGAAAATAATATG +AAGAAACAAAAAGAAATTCGAGTTACGTGCTCTAAGAAATGAATTTAAAA +AATTTATCGATGGAAAAATATTTTTAAGAAGAAAATGAGAAAATAATATG +AAGAAACGAAAAGAAATTCATTCGAAAATCGAGCGCGTAAATCCAGAGCT +ACAGTAATCAGTGAAAGAATTACTGTAGTTTTCGCTACTAGATATTTAGT +GCGTCAAATATGTTGCGCAATACACATTTCTGGAATTTTGTGTTTCCGTA +ATAAAATAAGTTTTTTGCGAGAACTACAAAAATATAACTATTTCTATTCC +AGGTGACCGGCCTCCCACATAACGTCGAGGCTGCCCGCAAGGAGATCGAG +ACGCACATCTTCCAGCGAACCGGAAATCTTCCAGAAACCGACAATGACTT +TGCCGGACAGTTGGCCGGTGTCTCGTTGATGGTGCAGAAGCAGCAACAGG +CTCAACAACAAATGCAGGAGGCTCAGCAACAATCGATGTTCTATCGAAGA +GCATTCGGCAACAGTAATCCGTTCAATCAGAAGGAGATGTCGTCGTCGCC +ATTCGGAATGGAGAGCTCGTTGGGATTGGACGCGTTGCTCCGCAGTTTCC +CATCGATGCGTAGTTCGTTGACTCCGGAATCTCTTTCCGGTACTGGACTG +TCTTCTCGTCCATCGTTGGGAGGAGGACAATCGGCGAAACAAGATCTGCC +AACCTACGACTACTGGGGAACCAACAACTCGCTTAATGATATTATGGAGA +ACGGTAAGCTTTTTTTGCGAATTTTAATAAGAATTTTAAATGACAAATAA +GGATTTTTCAGAAATTCTCAGCCGCAAGTACGATGCCCTGTCCGCATGGT +CGTCGATGGGATTGGAGAAACGCGAGGAATCCCCAACCAATGGGTATATA +TTTTTGAAGGAATTTTATAAATTTTTGAAATAAAACTAAAAATTGCAATT +TTCCTTCAAAGTTCTAAATTTTTGAAAGAAAATTTGATTTTCCGCTAAAA +AATTTAAAAAAAAAACAAGTTTTCGTGTTTTCCACTCGGAACCTGACGGC +TTCTTATCAATTTTTTAAATAAAAAATAACGTTTCTAAAACTCAGAATGT +TTAAAAAATTTCACATTAAAAAATTATTTTTCCGAAATCTTGAACCTATC +CGTTTTTGAAAATAAAAAAGAGTAAAATCGTAGTTTTCTCTATAAAAATT +ATAATTTTCATTTGAAATTCAAAAATTTTTAAATAAAATTGGATTTTGTC +CGTCAGAAATCTATAAAAAGAAAATTTTTTTTGAACAATAAAAGAAAAAT +TGTAATTTTCTTTTGAACTTCAAAAAAATATGTTTTTTTTCACATGCAAA +AAATTGATTTTTTCAAAACCTCGTTTTTGAGAGAAAAAGGTGAAATTCCA +ATTTTAAGAGGTAAAGTTAAATTTATTTATTTTATGAGAAAAACTTGAAA +TTTAAAGGAAAATTACTGAAATTTACAATTTATCATACATATTTTTTAAT +TTCGACATATCTCGAAATATCAAGTCGTAAATTTTTTCCACAAAAGTGTG +ATATTCTCTTTAAAAACTAGAAAATTTCAATTGTAAATTTATGAAAAATC +AAATTTTTTGCAGGCTCATGTCCTCCCTCAAAGGAACATCCGCCGGCTTC +GGTCTTCTCAGCACAATCTGGTCTGGCGGAAACATGAATCTGAGCCCAGG +ATCGTTGGCTTCAGCATCTGCCTCGCCGACTTCATCGACCTGCGATCACA +ACGATCATACTCTCGTGCCGATCAATGGATAAGCTGTGGATCCATTCATC +ATTCCATTACTATCGTGTAGACTCTCATCTAGCAAAAACCCATCCTCAAC +GAGTTCCAAATTCATCTTTCCATTCTTTAAAAGACTCTTTTTCCCATTTT +CTACTTTGTTCATCGGTGTACGAGTCCCTCCATTCCCATTTTCTCACCTC +TTTACTACATTACTAGAACACACAAAAATCACCATCATTCTCACCCCAAA +ATCCTAGACAAAAAAAACGAAAAAAATCACATATATTTATATATAACTAT +TATTATTTGTTATTCATATTTTTGAAATATCTATATTATATATATTTATA +TATGTAACCCATGCAGTCCCCCAATATATATTCCTACAGTAGGTTTTTTT +GGAAAATCTGTAACTTTCTCTATTATTCTTTTTTGCATTATGATAGGACG +ACCAACTCATGTTTTAAACAAAAATTATATATATTATAAGGATTTCCTCT +TTTCTCTCTATCTCTCACCTAGTGTTTAACTCCCAATTTTCCCCCTCTCT +ACTACGCACAACTAACGGAGAATTGAGAGGCCTTTTATATTTATAGCACC +TCTTTATAATTAAAAACTCGAGTGATCCCCACCTCACCCATCAAATTTAT +CGTATTTTGTAAAAGTTCTGATATATTCCACAGATTTTGGTGTATGTGAA +TGAAGCGATTCGTGTCGTCTCTCCATATTCTGGTATCCATAGCAACTCCC +CGAGCTTTTGGCTCACTCGCGCACGCCCTATACTATACCTTTACTATTAT +TAAATGCACTCAACAAATCCTATCCTGCGTCAATTGGCCGATCAATTGTC +CGAATTGCCACAATATGCACCATTGCGGGTAATAATAGCACAATAGTTGA +ATATATTAATAATTCAAAAATATTTATTATATTTTGAGGTGTCCCATTGT +TTCAGACATATATCCGCGCGACGATAAGTGCCACGTTGGGGGAAACGCCA +AAGAAAACGAGTAGGGATTTGACGTATAGAGGTGAAATTTTTAGAAAATT +TGAAATTTTCTGAAAAAAAAAGGATTTTTCTTTTATGAAAAATGCTCTTT +TCGCCAAAAAAATCACAATTTTCGACTTAAAAACTTCAAAATTTTTTCAG +GAACACACAATTCAAAATACAAAATATCTCGTAGCAAAAACTACAGTAAT +TCTTTAAATGACTACTGTAGAGCTTGTGTCGATTTACGGGCTCAATTTTA +AAATTAGATAAAAATGAGAAAATAAAGACACGAAGAAACGAATGAAAGTG +TAATATCGAAAATATTCGAAAATAAATAAATTTCAAAAATCGAGTCCGTA +AATCGACACAAGAGCTACAGTAGTCATTTAAAGAATTACTGTAGTTTTCG +TTACAAGATATTTTGCGCGTCAAATATATTGTGCAATATGCATTTTCAGA +ATTTTGTGTTTCCGTAATAGGTAAAATGTCAGAAAATCAAGGATTCAGTG +CAACCCCGCGTTCTACGGGTATTTTGGCCACGGCCACTTTTTGCAAAACT +GCAAAATAGGCGTTGTTATTTCATTTTCTGAAAAAAACATTGAAAATTAT +TATCGAGAAAGTACGATCTGACAAATTTCTCATAATTTATTTTTGATCTA +CCTGTTGAACTTTACTCCGCCCCCAATCTTGTTGCCGTTGTTATTTTGTT +GTAGCTGTCTTGTCGAAGGACGGGGAGGAGCCTAGTCAACAAGGTAGATA +AAAAATATATTATGAGAAATTTGTGCGATCGTATTTTTTCGATTATATAT +ATATATATATCTTCATGTAATTCTCATGAAATCTTGAAAAAAAACGCGAC +ACATGGTATTACCACGCCCACTTTTTATAATTTGAGCGCGTGCAATTTTT +TGTCGATAACATAGTTTCTATTTAAACAAAAAACATCGTGCGCCCACATT +GAAGAAAATCCTATAATTGGGCGTGGCCTTAACTCTGAAAATTTACAGAA +CGTGTCACCCATAGCATGATTGCCGATTGGCTCGAGCAGAATGGATATCC +AATATCATCTCAAGTCTTGAAAACAGAAATGTCTGGAAACTACATGGAGA +GTGCAGAAAAACACGTGGAAAATGGGGAAAAAATCGATAATCTATTGCGA +AGTCAGCTGAAAATCGATATTCGCGATGGCACCGGTGACGATTTTGAACG +AAAATCGATAAAATCGATTGGCGCCGGCCGCCCGTTTGCAAAAATTAATA +TGGTCGATAAACAGCGAGCACCGTTGAAAATTACACCGCTTAGTGATGAG +GAATTTCGAAAAACGATGCGGAAACGGATGGAAATGGAGAGGGAACGAGT +GAGTTGCGTTAAATAATTTTTTTTTGAAATATTTAACAAAAGTCGACAAG +GCGATTTTTTAAAATCGATGTTTCGCGACTTTTATTCAAAAGAAAAATTT +CAATGCCCTAAATCACTCAAATGATGATTAAAAAAGTATTTGCGCGCGCG +CGTAAAATTTAGTGCCAGCGTATGACACTATGTGGTGCAAACTTCACTCC +GGGTCCGACACTTTTTGGATTTTGCGCATCGCTATAAAGATTTCAGATCG +CGGCGTGAGAGCGGCGTTTGCGGCGCCGACATGAGAGTCCTACTTTCCTA +CTTTTCTTGGCAAAAAAATCGATCGATTTTTCAGCTCGCACGTCTATCCA +ACCAGGCAGAAGACGATTCCGACGATTCATCGTCCTCCTCCGACTCTTCC +ACGTCATCCGCGTCGTCATCTTCCGAGGAGAAGTTGACTTTTTCGGATAT +CTTGGGGAAACCCACAGCAGCTGGCGCGGAGAAAATGATCGAACTAAGCC +AAATTCCCAACGCATGGGGTCCGTCAAAATCCGCGTTAGTCACTGATGAC +GTGGCAAGCACTTCTGACCCACTTCCGGCGATTTTCAACGCACATCTTCC +GCCGCTCTCCATGGGACGACCACCGCTGACAAAAAGCGCGAAAAGTCGGG +AAATCGACGCCATTTTCGGCTCGGATAACGTGGATTATGATTTAGAGGAT +TTCGAGCAGGATGGCGTGGCGAAGAAAAAGTCTATACTGCCTATGGAGAA +AAAGAAGGAGGAAGCGAAACCAAAGGAACAGGAGCTAGTGGAGCCGTTGG +TCTTGTCAGAAGGTAACTTTGAACTTGCACCATGCAAAAATTTCGAAAAA +TTATGCACGTGGTCACTGGCTGTCCTTTTGCATAAGCTTGAAGCAAACGC +GCCTCATTGAGAATTCACGTTTGCGCCAACTCTCGCTATCCATTGGGCGT +GAGAGACGCAGATACTACTTTTTTCTCTGAACGTGAAAAACGCAAAGAAT +AACCGTTTTGCCGTCTGCATCTCTTCTTTCACACGCTATTTTGGCTGTGG +ACGAGGAATTCTCCTCTTCCAGGATTTTCTAGGCCATTTTCTCATATTTC +TCAAGTTTTCTCGTCCGCGAGAAAACGTGAATTTTGAGACAGCCAGCGAG +CACGTGATTATGCAACTCTCCTAAAAATCGATCATTGTTCCTGTAGCTTA +TAATTTTAAAGGCGCATATTCCGCTTGCGGAGCAAAAGTAAAAAAAAAAC +ATGCCTCTACATACAAATCGATGAATTTCCTGAAAAATCAATAATAAAAA +ATTTTCAGGAGAATCAATCGACGAGCTTGAAGATTTCGACACCGGTCTAC +TATCTTCCGGAGGATCCGATTATTCTTTTTAAAATTTTCTTCTTTTAAAA +AATTTCTTTTGAAATAAATAAATTCTCACCTAGGAATTTCAACAATTCAA +CTTGAAAAAAGTTCGCGCAAACTACGAACAAATGTGTGTCGAGCGGGCGG +AGCCACTGAGAAAGAGGAGCAAAATGTACACAAAACCATATTTGAGTGTA +ATTTTTCAAAGTTTGGCGCCGATTTTCTGTGAGAGATGAGTTTTCTCAAT +TTATATTTGGTTATTTTTATTTTAGTTCTTACTGGTAAATTTCTGGGTAA +GTCCTGATGACTTTGAAAACGAAAAAAACTCTTTCATTGATGCTAGTGCG +ATTGCTAGGAAAGCAACTTTTCAGTTACCAAGAAAAAGTCCAAGGCCATA +GGGATTAGCTGCGTGGCATAACAACTCATCCATCCTCGCAGATGCAAATC +CGCTCTATTGGCAAATAACATGGAAGAGTATAAACATTTTCTCTTCCACA +CGGAAACCTAGTCCCCTTGGGGAGCGGTAGTGCCCACAACCCCGCATGTT +TACCAAACTACACAGACAGCGCTATTGTCTGCAAGTGGCAAAAAATGGCC +GCCGAAAATTTTTACAATGTAAATAATTTTCAAAGTGTTACTATTTGCAC +CTTTTTGGCAAAAATTCCATAAGTAAGAAATTTGATGGAAGAGATGCGAG +GTGCGGGGAGTCTGAAAATGGCTGCATGGCCTGTATGTGACCTGTGTATG +TGGCCTAAAGGTCTAGTTACCCCTAGAAATCAAAGTTCAGTTCAGCAAAG +AGACTTTATTTTCAGCACTCCAACAAGAGGCAGAAACTCAACGGTACGAC +GGATGGTACAACAACCTGGCGAACAGTGAATGGGGTTCTGCTGGTAGGTT +TTTTTGGAAGAGAAATGACGTCACACTGACCTACTCCTTCAGGAAGTCGG +CTGCATAGAGATGCACGTTCCTACTACTCAGACGGTGTATATTCAGTGAA +TAACTCACTTCCGTCCGCCCGTGAACTCTCCGATATACTATTTAAAGGAG +AGTCCGGTATTCCTAATACAAGAGGATGCACCACTTTATTGGCATTTTTC +AGTTTGTATTTTTTTAATACTTATAGTAGCCAATGTTTGTAGGTCAAGTA +GTTGCTTATGAAATAATGCAATCAAATGGAGTATCCTGTCCACTAGAGAC +ACTTAAAATTCAAGTACCCCTATGTGATAATGTATTTGATAACGAATGCG +AGGGGAAAACTACAATCCCATTTTACCGTGCAAAATACGACAAAGCAACT +GGAAATGGTCTTAACTCGCCTCGAGAACAAATCAATGAACGGACTTCATG +GATTGATGGATCATTCATCTATGGTACCACCCAGCCATGGGTGTCCGCAT +TAAGATCTTTTAAACAAGGACGGTTAGCTGAAGGTGTACCTGGATATCCA +CCACTTAACAACCCACATATTCCATTGAATAACCCCGCTCCGCCACAAGT +ACATCGATTGATGAGTCCAGATAGATTATTTAGTGAGTTCATTGTTCTAT +AGAAAAGTATAAATATTTAAAATTGAAGTGTTGGGAGACTCGCGTGTGAA +TGAGAATCCTGGTCTTCTTTCATTTGGTCTGATCCTCTTCCGTTGGCATA +ACTACAATGCAAATCAAATCTATCGAGAACATCCTGACTGGACAGACGAG +CAAATCTTCCAGGCAGCACGTCGTTTGGTGATTGCATCTATGCAGAAGAT +TATTGCATATGACTTTGTTCCAGGACTTCTAGGTTACTCAACTATCATTT +AATAGCTTAAACTCAGTGTTTCTTTTAAGGTGAAGACGTTCGTTTGTCAA +ACTACACCAAATACATGCCACATGTTCCACCTGGAATCTCGCATGCTTTT +GGAGCAGCCGCCTTCAGGTTCCCTCACTCAATTGTGCCACCAGCAATGCT +TCTGAGAAAACGAGGAAATAAATGTGAATTCCGGACGGAAGTTGGTGGAT +ATCCTGCATTGAGATTGTGCCAGAATTGGTGGAATGCACAGGATATTGTG +AAGGAGTACAGTGTGGATGAGATTATTCTTGGTTAGTTCATACTTGAGTG +GTTATATAATAAAGATTGTAATTTCAGGAATGGCAAGCCAGATAGCTGAA +CGAGATGATAACATAGTAGTCGAAGATCTTCGTGATTACATCTTCGGACC +AATGCATTTCTCTCGTTTGGATGTTGTTGCTTCATCAATAATGAGAGGAA +GGGACAATGGAGTACCACCGTATAATGAATTGAGAAGAACATTCGGACTT +GCACCAAAGACATGGGAGACAATGAATGAAGATTTCTACAAGAAGCATAC +TGCAAAAGTGGAAAAGTTGAAAGAGTTGTATGGAGGCAATATTTTATATC +TGGATGCTTATGTTGGAGGGTAAGCGTTTTTTATAAATTAAGTTAGAGAT +CCTCCAATATACCCTCATAACATATTGTATCAGTTTACTTCATCAATAAT +TCAGCTTGAACCATTTAGAATGCTGGAAGGAGGTGAAAATGGGCCTGGAG +AGATGTTCAAAGAAATCATAAAGGATCAGTTCACCCGTATTCGAGATGGA +GATCGATTCTGGTTTGAGAATAAACTAAATAGATTATTCACTGATGAAGA +AGTTCAAATGATTCATAGTATTACACTTCGTGATATTATCAAAGCAACAA +CCGATATCGATGAGACGATGCTTCAGAAGGATGTGAGTTTATTGTAAACA +CCCGTTGGTGATGATCGAGTAAGTTAATAGCATGTTTCATTCCAGTCATT +GATTGATATTTTGTCATGAATTGTTATATAACAATATATGTATGTATTAT +ATTACTCATGTCTCAATATTGCATTTAATTTCCAGGTATTTTTCTTCAAA +GAAGGTGATCCATGCCCCCAGCCGTTCCAAGTGAATACCATTGGACTTGA +GCCTTGTGCTCCACTTATTCAATCCACCTACTGGGATGATAACGATACTA +CTTATATCTACACTCTAATTGGTTTGGCGTGTATTCCTTTAAGTCAGTCT +TTATTTCAATCTAAATGACTACCGATAGAGACTCAGCGATTATAGAGTTG +ATCAAGCTAAGAACTTTCAGTTTGCTATAGTATCGGTCATTATATGGTTG +AACGACGTATCCGAATAGGTCATAACAGTGCTTGTGACAGCTTGACTACT +GACTTTTCAACAGAAAGTCCCAAAGTTAATGTCTACAAAGTGAATGGTTC +GTTATTTTTTCATACTTGATTTTTATTTAAATTATACGGTGAATCTGTTA +CAGCTTTGGAATGGCTTCAAGAAGAGTACATACGGCAAGTTCGGATAGAA +ATAGAGAATACCACGTTGACAGTGAAGAAGCCACGTGGTGGAATCCTTCG +AAAAATTCGTTTTGAAACTGGACAGAAGATTGAGGTATTCCACTCTATAC +CGAATCCATCAGCAATGCACGGACCATTTGTACTTTTGTCTCAAAAGAAT +AATCATCATTTGGTGATAAGATTGTCGTCTGATAGAGATTTATCTAAATT +TTTGGATCAAATTAGACAGGCGGCTAGTGGAATCAATGCAGAGGTTATCA +TAAAGGATGAGGAGAATTCTGTGAGTTTACTTCAAGAAATACGTCGAATC +TGGAAATTATTTCAGATTCTCTTGTCCCAAGCAATCACAAAAGAACGCCG +TCAAGACCGACTGGACCTGTTCTTCCGTGAAGCCTACGCAAAAGCATTCA +ATGATAGTGAACTTCAAGATTCGGAAACTTCATTTGACTCATCGAATGAT +GATATATTAAATGAGACAATATCTCGTGAGGAATTGGCAAGTGCAATGGG +AATGAAAGCTAATAATGAGTTTGTGAAGAGAATGTTCGCGATGACTGCAA +AACATAATGAGGATTCGCTCAGTTTCAATGAGTTTTTGACAGTATTGAGG +GAGTTTGTTAATGGTGAGTATGATTTACTAAAGTTCTGATCACAAAAACT +ACACGTGAATGAATGTTCCAGTCCGTTTTACACTAGGTTCGGTAAATATG +TATAATGTTATAGTGACTGTTACATGTTGAAGCAGTAGTCTTCTTTTCTT +TGAATGGCAACAAAAAGGCTCCCTCATTATTTAAGCTGTATTTCACTGCG +AATAACGGCTTAATGTGCTATTTAAACATTCGGGTCTATTAGTCTTTTAG +TATATTGTCGCGCATACTAAGGCTCGCTTTAATAATCAGTTTGAAACGCG +AATTTGATGGTGTTAAATACGATTTTAATTTGGGAATTGTTCACAATTAG +ATGCTATCTTGACTAATAATAATTAAATACAGAAACAAAAAACTTTTAAT +GGACAAAAATCACTCCGAAACTACCCAAATCGGCATTAGGTTAATGTCTT +TGATTACTCACCTTCTTTCCTAATTTCCAGCTCCTCAAAAGCAAAAACTG +CAAACTCTATTCAAAATGTGTGATTTGGAGGGAAAGAACAAGGTACTCCG +AAAGGATCTCGCAGAACTCGTCAAGTCCCTCAATCAAACCGCCGGAGTTC +ACATTACCGAAAGTGTGCAGCTTCGATTATTCAATGACGTGCTGCACAAG +TCTGGTATACATCCCTGTTTAGTATGCCAAGTATTATAAGAAGTTTCAGG +AGTAAGTGACGATGCGGAGTACTTGACTTGTAATAATTTCGACGCATTGT +TCTCGGAGATCTCTGACGTCCAGCCGATCGGTCTGCCATTTAATAGGAAG +AATTATAACTCACATATCAAGGAGTATGTTGTTGAATTCAAATCCGCAAG +TAAATACAAACTTCAGGCCATCATGCCACACCTCATTCCCAATAGTGGAC +CACTCTACTCCTGCTCCACTTTCTCTGATTCAGAGAATTTGTGCATTCCT +GGAAACCTATCGCCAACACGTCTTCATCATCTTCTGCTTTGTCGCCATTA +ACATTGTCCTTTTTTTCGAACTTTTCTGGCGTAAGTTTACTGTTTAGTTC +GGTTTTCAAAAGCAATATTCAATTAAGATTCCCGCTACCTAAACGAAGAT +CGAGACCTCCGTCGGGTGATGGGTGCCGGGATCGCTATCACTCTCTCTTC +TGCGGGAGCCTTGTCATTTTGCATGGCGTTGATATTGCTCACAGTTTGTA +GAAATATTATAACACTGCTTCGAGAGACAGTTATTGCGCAGTATATTCCA +TTTGACTCGGCTATCGCGTTCCATAAGGTAAGAGCCTCTCTCTTGGCCTA +GCGCTGTAAATAAAACTGCCAAATTTTTAAACTCCATCAATTTCAGATCG +TCGCATTATTCACCCTATTCTGGTCTACCCTTCACACCATCGGCCATTGT +GTTAACTTTTATCACGTTGGAACTCAAAGCGACCGTGGACTTGCTTGTCT +CTTCCAGGAAACATTTTTCGGGTAAGCCCCACCTACTCGGTAGATCTCTC +AGTAGATTGAACGTTGGCTTGCTTTCAGATCTGACGTCGTGCCTACCCTA +AGCTATTGGTTCTATGGAACAATTACTGGGTTGACGGGAATTGGATTAGT +TATTGTTATGAGTATCATTTATGTGTTCGCATTGCCAAAGTTCACTAGAA +GAGCATATCACGCGTTCCGGCTGACTCATCTTTTGAATATTGGGTTTTAT +GCACTCACTATTCTTCACGGACTTCCTTCACTTTTTGGGGTAAGGCTTAA +TTTAATTTGATTCATTTACGCTCTTTTTACGCTCTTGACGTCAATATTTG +TTACAGTCTCCCAAATTTGGCTACTACGTTGTTGGACCCATTGTCCTTTT +TGTAATCGATCGTATAATTGGGTTGATGCAATATTACAAGTCGTTGGATA +TTGCCCATGCAGAAATCCTTCCATCAGATATTATATACATCGAGTACCGT +CGTCCAAGAGAATTTGAATATAAATCAGGACAATGGATTACTGTATCATC +ACCATCTATATCATGTACCTTTAATGAATCTCACGCATTCTCGATTGCCT +CAAGTCCACAGGATGAGAATATGAAGTTGTATATAAAAGCAGTTGGACCA +TGGACATGGAAGTTGAGAAGTGAATTGATAAGATCATTGAATACAGGGTC +ACCATTCCCATTAATTCATATGAAAGGACCATATGGTGATGGTAATCAGG +AATGGATGAATTATGAAGTTGCAATAATGGTTGGAGCAGGAATCGGAGTG +ACTCCATATGCATCCACGCTTGTTGATCTTGTACAAAAAACATCAAGTGA +CTCGTTTCATAGAGTTCGATGTCGTAAAGTATATTTCCTATGGGTGTGTT +CGAGTCACAAGAACTTTGAATGGTTTGTGGATATGCTGAAAAATGTTGAA +AATCAAGCAAAGCCGGGAATCCTGGAGACACACATATTCGTCACTCAGAT +GTTCCATAAGTTTGATTTAAGAACTACTATGCTTGTGAGTTTTTTATGCG +TTTTTGGTTTTTTAGTGGTATAACTCTAAAACTAAATGTTTGGAGAAAAA +GGCTTAACTAATAAAATGTTGCTCATAACTTTTTCTATGCAATAAAATAT +GTTTCAAAATTTCATCCGAGATCTCACAAGTCCAAATTTGATTATTTTTC +TTAAAACGAGTATATTTCAAGACCGAAAAGTTTTCTTGAAAAAATGGTAT +ATTTTTTGCACATAATCATTTTTTCATAAAGTGCTCTGCAAATCAGAAAT +TAAAGTTCGAACAGTCTTATAGTTAGTACCGTGACATTTATTGTAACTTA +AAAAAAAAAATTACGCGACATAGAAACGCTCGATTATCTGAAAAACCAAA +TTGGATTTTGATTCTAGTTAATTTATTTTCAAAAATAAACATATTTTGTG +ATAATTGTAAACTAAAAACTATACCTGAATATTTTTATAAATTTTATGTG +GTTTTTGGTTTCAGGATTAAAACAATGGTAAAATACTACCCTAACGGCTT +ACCCAAGGCTCAGAAAATTGTAGTTAGTCTCAACAAATTAATACATATCA +TTTCTTATTTGCAGTACATTTGCGAGAAGCACTTCCGTGCCACCAACTCA +GGCATATCAATGTTCACTGGCCTACACGCTAAGAATCATTTCGGACGGCC +CAACTTCAAAGCTTTCTTCCAATTTATTCAGAGTGAACATAAGGAGGTTA +GTTTCATGGTTTTAACCTCTAAATAAAGCAAATTTGCAGCAATCCGAAAT +TGGAGTGTTCAGTTGTGGACCTGTAAACTTAAATGAAAGTATAGCTGAAG +GATGTGCAGATGCCAATCGACAACGAGATGCTCCGTCATTTGCACACCGC +TTTGAAACTTTCTAATCTTTCTACTGTTACTTACTATGAAAATCATAAAA +ATTAAGACGCTTCATGAATAAAACATTGAGAAAAAAAACCTGAAATAAAG +AATTTTCACATTTGTCCAGGTAGTATATATCCCCAATACAAACATTTTGA +GACGCGAACCTTCCCAAATAATCATCAGACATTGTTCTGTAATTAGGCAA +AAAACCAGCCCCCTAGCCTCCTCCCTCACCACAAATAAAACCAATTCCCC +CATTTCCCCCCAGTTCATTCACCAACAATGAGTTTGTTCAAAGTATACAC +CTCGTTTTCTTTGTTTTTCTCCGTTCTATTCCTTCTCGTCGCTTTTATTG +TGATCTATGACATTTTCGATGAAATTCGCGAATTTCAAGAAGTAATCGAA +AAAGATGCCAGGAAGTTTGAGGTAAGGCAATATGTGGTGCAGCAATAATT +TCCGCATTTTTCGTAGATCATACCGTTATGGGACAGTCTGACACCACGTG +ATAAAATAGTATACTAAGTATTACAAGCAAGGTTGAAACGAAAATGAAAT +TTCGTTTTCGAAAACGAAAACGAGAATTTTCGTTTTAAACGCGAAAAACG +AAAACGAAAACGAAAATATCAGTTTTGTCCAATTTAATTGGTAAAATATA +GATTTCATGAAATATTAGGTCCATTTTCGAATCAATAATAAACAAACAAT +AGTTTTATTACAAAAAAAACAATAAAAATTAAATAAAGCAAAAGAACAAT +AACAATAACACTTGCTGAACAACTATTCCATTAATCTAAACCAATTTTAA +AGCCTAAAACTTTTTGATTTTGCTGTAAGAACACAGACTTGCTCAACGAC +TTTGTAGACATCTTTCTTCTCAGCTTTGTAGAAACGCGGCCAGCTCCTGA +AAAAACTCGTTCCGATTCAGCAGATGAAGCTGGAGTTGTCAGATATCTGT +TCGCTATTTGAGAAAGCAATGGAAACTTAGATCGATTGAGCGGATTTTGC +CAAAAAACAGCGGGGTCTGATTTTCTATTGTTATCGGTATCGTAGAAAAC +TTCAACTTCTGCACTAGCACAGAGCATGGAATCTACAGGCGCTTTGTCTT +TTCTTTTTCTGATCTTGGAATGCTTTTTCTCGTAAGCTTCAAACAGGTCG +TCTATTCCCTCAAGAGTTTCATTTTCTGGCTCATCGACTGCTTCTTCCTC +TTCTTTTGATAATCCTTGAGCTAAGCTCAAAACAAGCTCTTTTCCGTCAC +AATATTTTCTTTTGTATCGTGGGTCAATGTTTGATGCAACAATCAGTTTG +AATGTCACCAGTCGGTGCCCGCGCCGTAGGTGCGGTCAACGGCTGGTATG +TATATAAAATATATTAGATTGAAAATATAACATTGAAAAAAAAAAACAAA +CATTGAAACACAATAAAAATCAAAATATAGACGCTCTTTATTCTTGAATA +AAAATAAGAATTACGAATTGTTCACTGGGAGTCAGCTTATTTCTTGTACA +AAATAATGATTTTGACCAGTGTCAGCTCAAAAAAAATACGTTGACAGAGA +GAGGTGGCATTTTCGTTTTTTCGAAAATTTTCGAAAACGAAAACGAAAAA +ATCATTTTCGCCAAAAACCCGAAAATAACGAAAAAACGAAAATTCGAAAA +CGAAAAAGTGACAAGCCTGATTACAAGGTCGGTATTTCATAATATGAATA +TTGTAGAGAAAGGTTACTAGCGATGATTCCAAAAAAATTTAGATTCATCA +GAGATGTACACCCAAATACCCAAGGCATAGGCCCTAATTATTGATTAGTC +ACAACTTCTTACTTCCAACAAGCTTTTCCTATTTTTCCAGTTCTACTCCA +CCGCCGCCTCACGTTCAATTGCCGGTCTCGACAAGCGGAGCCTATTCGGA +GGAGCTGTTTCTTTTTAGTTGTATATACATCTATTCAAAATTAAAAGTCA +TTGTTGTTGTTACCCATAAAACAGTGAATGAAAAAAAATGAAGTCTAGAC +AGAAAATGTAAAGCTGGCACAGAATACTCAAAGAAGCATAAAATATGTAT +AATAATGATGATATAGGGAAGGTTAGAACGTTTCAAAGCGATGTGCAAAT +GAAGGAGCATCTCGTTGTCGGTTGGCATCTGCACATCCTTCAGCTATACT +TTCATTCAAGTTTACAGGTCCACAACTGAACACTCCGATTTTGGATTGCT +GCAAATTTGCTTTATTTAGAGGTTAAAAAGCATTTAACTAACCTCCTTAT +GTTCACTCTGAATAAATTGGAAGAAAGCTTTGAAGTTGGGCCGTCCGAAA +TGGTTCTTAGCGTGGAGACCAGTAAACATTGAAATTCCTGAGTTGGTGGC +ACGGAAGTGCTTCTCGCAAATGTACTGCAAATAAGATGTTAAAGTTTAAA +AGCTTCAGACCTTAAGATGCCACTGCGTTTAAATGCGTCCGCTTTAATCA +GTTTATAACCAAACCTGACGTTTGATTTTGAAAATTATCTTCAATAAACT +CACAAGCATAGTAGTTCTCAAATCAAACTTGTGGAACGTCTGAGTGACAA +AGATATGTGTCTCCAAAATTCCCGACCTTGCTTGGTCTTCCACGTTCTTG +AGCACATCCACAAACCATTCATAGTTCTTGTGAGTTGAGCACACCCATAG +GAAATATACTTTACGGCAACGAACTCTGTGAAATGAGTCACTTGATGTTC +GTTGTACAAGATCAACAAGTGTCGATGCATATGGAGTCACTCCGATTCCT +GCTCCAACCATTATTGCAACTTCATAATCCATCCATTCTTGGTTACCATC +ACCATATGGTCCTTTCATATGGATTAATGGAAATGGCGATCCTGTATTCA +ATGATCTTATCAATTCGCTTCTCAACTTCCATGTCCATGGTCCAACTGCT +TTTATATACAACTTCATATTCTCATCCTGTGGACTTGAGGCAATCGAGAA +TGCGTGAGATTCATTAAAGGTACATGATATTGATGGTGATGATACAGTAA +CCCATTGTCCTGATTTATATTTAAACTCTCTTGGACGACGGTACTCGATG +TATATAATATCTGATGGAAGGATTTCTGCGTTTACAATTTCTAATTTTTT +GTAATATTGCATCAAACCAATTATGCGATCAATTACAAATAACACGATGG +GACCAACAACGTAGTAGCCAAATTTGGGAGACTGTAACAAATATTGAAGA +AACTTCTTGAACCGAACAGTGGCAAAAACTCACATCCAACAACTTTGGAA +GCCCATGAAGAAGAGTAAGTGCGTAAAAGGCAATATTGAGAAGATGTGTG +AGCCGGAATGCGTGATAAGCTCTCTTAATGAAACATGGTAACGCGAAAAC +ATAAATGATGCACATGACAGCGACCAATGCAATTCCTGTCAGACCTGTAA +TTGTGCTGAAGAACCAGTAACTGATTGAAGGAAGGAAGTTGGATCTGAAA +GTTATTTGATGAAAGTTGTTGACAGTCTTGAGGGAGTTTGTTAATGGTGC +GTATTCTAGTAAGATTGAATGCAAAAATGAATTCAAGTAAAGTATTACCC +AAAGAATGCTTCCTGAAAGAGACAAGCAAGACCTTCTTGACTTTGAGTTC +CAACGTGATAGAAATTGACACAATGTCCAACGGTGTGAAGAGTGGCCCAG +AAAGCCGCAAAGAGCGCAACGATCTAGAAATGTTCAGTTATTATAGAGTT +TTTGATACTGGCGGTCATAATAAACAATACTTTGTCCGAAATATTAGTTT +TCCCATTGTTTATCATAGTTTATTTTTTTATTCAAAAATCTGCCCTCTCT +ACAGAACACTTATATGTAAAGTAGACTTAAAAACATCTGAGTTTTTTGAG +CAACAAGAGACCCACACTCGTTCTAAAAAGAAATATATCTGGAGCACAGG +AAAATCTAAACTTAGGAGACACTTTTTTGTCAACAGAACACTACACACAA +TGAAGCAACACTGATCTAATGTTACCTTATCCTCACTTCTATTCATCATT +TATTCTTGCCTTTTATACATCGATATTTGTGTTTTTTGCTTCTTCTCCAA +TGTAGCCATTATTTTTTTTCTCATCTCTTTTTATTTTTGTTCCATTTTTA +TTTATGTAACCACTTGTGATGGTTTGTATCTATTAATGTGTGTTTTTTTT +CTACCTCACGATATCTTACTATCGTAATAAATTTAAAAAAATTAAACACT +TACAAGTTTAGGATAACATCGCTATATCATAAGTTCACATCTGGCTGAGA +AACACCATGTTCGATGCAAAGATCTTTCCTTTCATGCTTGTATTCTATTT +TAAAAAATCTTTTCAAAACATTGGGTATGCACAGTACAGTTATCCTACTT +GCATTAAACCTCCGCATTACTGTACAGATAATAAAATAACAAGTTTTCCC +TTATATCTGAACATGCTAAATATTTTTAAAAACAACTGATTTGACAAAAT +TTACTAATGCAATAATAATATTTAAAAAATGTGTTACACGCTGCCCTAAC +GTTTCTCACCTTGTGGAACGCAATAGCCGAGTCAAATGGAATATACTGCG +CAATGACTGTCTCTCGAAGAAGTGTGATTATGTTTCTACAAACTGTCAGC +AATATCAACGCCATGCAAAATGACAAGGCTCCCGCGGCACCACGAGTAAT +AGCGATTCCAGCTCCCATTACTCGTCGGAGATCCCTGTTTTCCGCCATGT +AACGATAATCTGAAAACTAAATTAACATGAGCTCCCAATTATATGAACTT +ACGCCAAAACCGTTCGAAGAAAAGAACAAGATTGATGGCAACAAAGCAGA +AGACAATGAAAACGTGTTGGCGATAGGTCTCCAAGAACGCTGAAACTTTG +TGGATCAAAGTTAGCGGTGCTGAACTGTTGATGGATCGATCCACGACGGC +AAATGAGTTCAGAGAAGATGTTCTAAAAGTTATAATTGTTATACAGTCAG +AGTCCTCCTGAATACTCACTCTCCAATACTTGGCTGATAGTTCTTTCGAT +TGAACGGCAGTCCAACTGGTTGCTTGTCAGGTATATCCGAGAACAGAGCA +TTGAAATCGTCGTAAGTCAGGTACTTGGCATCATTGCTCACTCCTGCATA +GTGCAACACTTCATTGAATAATCGAAGCTGCACACTTTCAGTAATGTGAA +CTCCAGCGGTTTGATTGAGGGACTTGACGAGTTCCGCGAGATCCTTTCGG +AGTACCTTGTTCTTTCCCTCCAAATCACACATTTTGAATAGAGTTTGCAG +TTTTTGCTTTTGAGGAGCTGGAAATTAAAGTAGGTGGTGCATAACATTTT +TTAAAGGCAGTGTTGGTTTTTCTACTGTTCAGTAAAAGAAAATCTACAAT +TGACTAAATTCTCAATACTTTGATGCCATATTAGTTGTGACCTCCCTGTC +ACACGAGAACTTTCTACAGTGCTCGCAAATTCTATAGGACTCCCCCGAAT +AAATTCAGATTCAGAATAAATAACCTTTAGAACTTTTACTATCTCGAAAT +ATTGCCGACCATAGGACACCGAGTTTCACCTCACGGCTAATGAACCTACA +AAATGTTAATCGGTCGCTAATCCCGGCCTAGTTTAAATTCAGATCAGAAG +AAATAAATTTCTTTTCGCAGGAGACTTCGGCTCTCTTGAACCAAAACCTT +TTATATGTAGTTTTGTACGTACAAAATCAAAGACAGTTCAAAACAACTTT +ACCGCTACTGCTGTTACACGTAATTAAGCTGCATTAAGAAATTATATTTA +TTCAATTAGAACTTATGTTAATGGGAAACACGCCGGAACATTCTAGAACG +TAGTCTTTGTATCACAACAAATTTATGCTGAAATACTCACCATTAACAAA +CTCTCTCAAGACTGTCAAAAACTCATTGAAACTGAGCGAATCCTCATTAT +GTTTTGCAGTCATCGCGAACATTCTCTTCACAAACTCATTATTCGCTTTC +ATTCCCATTGCACTTGCCAGTTCCTCACGAGATATTGTCTCATTTAATAT +ATCATCATTTGATGAGTCAAATGAAGTTTCCGAATCTTGAAGTTCACTAT +CATTGAATGCTTTTGCGTAGGCTTCACGGAAGAACAGGTCCAGTCGGTCT +TGACGGCGTTCTTTTGTGATTGCTTGGGATAAGAGAATCTGAAATAATTT +CCAGATTCAACGTATTTCTTGAAGTAAACTCACAGAATTCTCCTCATCCT +TTATGATAACCTCTGCATTGATTCCACTAGCCGCCTGTCTAATTTGATCC +AAAAATTTAGATAAATCTCTATCAGACGACAATCTTATCACCAAATGATG +ATTATTCTTTTGAGACAGAAGTACAAATGGTCCGTGCATTGCTGATGGAT +TCGGCATAGAGTGGAATAACTCAATCTTCTGTCCAGTTTCAAAACGAATT +TTTCGAAGGATTCCACCGCGTGGCTTCTTTACTGCCAACGTGGTGTTTTC +TATTTCTATCCTGACCTGTCGTATGTACTCTTCTTGAAGCCATTCCAAAG +CATTTACACCATAAATATCTCCCTTCGCGCCACAATCATCATTTGCAAAG +TCAGTAGTTAGGCTGTCACAAGCACTGTTGTGGCCAATAGCAATGCGACG +ATTAACCAAGTATCGGCCAATTCCATAGCAAACTGAAAGCATTTTGGTTT +GTATGGAACTAGATGCAATAGCTCACTTAATGGCACACATGCTAATCCAA +TTAGGGTGAAAACATAAGTGGTGTCATTATCAGTCCAATAAGTTGATTGC +ATAAATGGAACACATGGTTCAAGTCCAGTTGTGTTCACTTGGAATGGTTG +CGGGCACGGGTCACCTTCCTTGAAGAAGAATACCTGGAGTGATAAATACA +TTGCAATGCGGAATTCAAAAGAACATAATAATAAACCATTAAATTTGGAA +AGTAACTTACATCCTTCTGAAGCATTGTCTCATCGATATCGGTGGTTGCT +TTGATAATATCTCGAAGTGTAATACTATGAATCATTTGAACTTCTTCATC +AGTGAATAATCCATTCAATTTATTCTCAAACCAGAATCTATCTCCATCAC +GAATACGGGTGAATTGATCCTTTATGATTTCTTTGAACAACTCTCCAGGC +CCATTTTCACCTCCTTCCAGCATTCTAAAATAATAACGTTTGATTAACGT +AATCCAATATATGTGCACTGAGAAAGAAACAAGTATGCGTAATTTATTCT +GCCTAGATTTGCAAAAAAAACTACCTTGCATGGGTAACGTTTGAAATACC +GAAGGAATTGCACTATAAAACTGAGGTGACATACAACTTCCAGAGTTTAT +GCCTGCTACAAATTTTAGAGTTTGACCAAAAGAAGCCGTTAGAAGTTTAC +TCGTGAGAACTTTTTAACCCTTGAGAAGATTTAGTGAATATTCAAAATTC +CACACTTCTTAAACCAATCAGTTATGTTAAAACGAATTGATTTTCATTGT +TTTTGCTTGAAACTCTTCGAATTCACCGCATTTTAAGTTAAGCATTCCAC +TTTAAACCCAAAACTAACCCTCCTACATAAGCATCCAAATATAAAATATT +GCCTCCATACAACTCTTTCAACTTCTCCACCTTTGCAGTATGCTTCTTGT +AAAAGTCTTCATTCATTGTCTCCCATGTCTTTGGCGCAAGTCCGAATGTT +CTTCTCAATTCATTATACGGTGGTACTCCATTGTCCCTTCCTCTCATTAT +TGATGAAGCAACAACATCCAAACGAGAGAAATGCATTGGTCCGAAGATGT +AATCACGAAGATCTTCAACTACTATGTTATCATCTCGTTCAGCTATCTGG +CTTGCCATTCCTGAAATTACAACCTTTATTATATAACCACTCAAGCATGA +ACTAACCAAGAATAATCTCATCCACACTGTACTCCTTTACAATATCCTGC +GCATTCCACCAATTCTGGCACAATCTCAATGCAGGATATCCACCAACTTC +CGTCCGGAATTCACATTTATTTCCTCGTTTTCTCAGAAGCATTGCTGGTG +GCACAATTGAGTGAGGGAACCTGAAGGCGGCTGCTCCAAAAGCATGCGAG +ATTCCAGGTGGAACATGTGGCATGTATTTGGTGTAGTTTGACAAACGAAC +GTCTTCACCTTAAAAGAAACACTGAGTTTAAGGTATTATAATATAGTTGA +TTAACCTAACAGCCCTGGAACAAAGTCATATGCAATAATCTTCTGCATAG +ATGCAATCACCAAACGACGTGCTGCCTGGAAGATTTGTTCGTCTGTCCAG +TCAGGATGTTCTCGATGGATTTGATTTGCATTGTAGTTATGCCAACGGAA +GAGGATCAGACCAAATGAGAGAAGACCTGGATTCTCATTCACACGCGAGT +CTCCCAACACTTCAAGTTTAAATATTTATACTTTTCTATAAAACTATGAA +CTCACTAAATAATCTATCTGGACTCATCAATCGATGTACTTGTGGCGGAG +CGGGGTTATTCAATGGAATATGTGGGTTGTTAAGTGGTGGATATCCAGGT +ACACCTTCAGCCAACCGCCCTTGTTTGAAAGATCTTAATGAGGACACCCA +TGGCTGGGTGGTACCATAGATGAATGATCCATCAATCCATGAAGTCCGTT +CATTGATTTGTTCTCGAGGTGAGTTGAGCCCATTTCCAGTTGCTTTATCG +TATTTGGCACGTGTAAATGGGATTTCTGTCTTTCCCTCACATTCTTTATC +AAATACATTATCACATAGGGGTACTTGAATTTTAAGTGTCTCTAGTGGAC +AGGATACTCCATTTGATTGCATTATTTCATAAGCAACTACTTGACCTATA +ATTATTATTACTAATTTTTGAGGTAGAGGGCAATAAAAACGAACTGAAAA +ATGCCAATAAAGTCGTGCATCCTCTTGTATTAGGTATACCGGACTCTCCT +TTGAATAGTATATCGGAGAGTTCACGGGCGGACGGAAGTGAGTTATTCAC +TGAATATACACCGTCTGAGTAGTAGGAACGTGCATCTCTATGCAGCCGAC +TTCCTGAAGGAGTAGGTCAATGTAACGTCATTTCTCTTCCGAAAAAACCT +ACCAGCAGAACCCCATTCACTATTCGCCAGATTGTTGTACCATCCGTCGT +ATCTTTGAAATTCCTCATTTTGTTGGATTCCTGAAAAGATAAATGTTACG +AGTTTTTGATTTCCAGGCCACCAAAATCTATATGATGGCCTAGGTTCCTT +ATTGAAATTTCTAGGTCACACATGCTCCCTTCACTACATTTTCACACCGA +TTCGTGCATTTTCTCACTGAACGCGCAAATTTCCGGTCAGTAGCGGAGCA +GAGCAAACATTTGCCCCGCCACCCGAAACAATTATTTTCGTATCATTTTC +GCACCTATATTTATTCTGTTTGTTTGCCTATTTTTTGTACATTTTATCCT +TTTTCTTGTATTGGGCGACGATGGCAAGGTCAGTAAAACAGGAAATTGTT +CCTGATAACTCGGGAATTTCAGGAATTTTTCCAAAATTGGTTGGGAAACC +ACCACTTTGTTGAAATTCGAAAGATACACATTTTGTTATTTAGGTGTAAA +CATGAACACTTTCTTAGGTAAACTATGTGATTTTTATGAAAAAGAACACA +GACACCGGGTGGCACACAGAGCTTATCAGTAAACAGCTATCAGTGATTTT +GAAATTTTGGAGGGGCAGAAATGTTGCGGACAAGGAAAATTTTTGTTTGG +AATTTGAAGTTTTGAAATACGCAATTTGAGAATTTTTGAACATTTTTTTG +TAATTTTTATCCCATTCATTTTTAACCTAACATTTTGAAAATCTAGCACA +GAAAATAGTACAGACACGTTCAATTGAGCTATTCCAAAAATTATCAATAT +AGCGCACTTGGTGTCCATCTTCCTTAACTGTTTGCAATTAGTCTCTCTTT +ACAAGAAATCAGCTACTATTTGAACAGATCTTGAACACATTTTCAAAGAT +CGGCTCAAGATCAAAAGCCTCTTAAACATTTAAGATAGCAGGTCCGCTCT +GTTGACAAATTTTCCACCCGGTCCTCCGAAAGGAATTTTTTTGGTCATCC +AACAACCTAGACCATGACGGCACCGATCATGCAATTTGCCTGCTTATAAA +AAACGATATTTCTAGGCCACCCATTTTTAAATATTTTTTTGCCTAGTCTT +AGCTATGTGGAATAAATTCTAGGTCAGGAGGTTTTCTAGGCCACGTAATT +CCACTCACCTTTCCCTCCAAAAATTGAACTGAACAGTATAGCTATGTACA +GCACATGTTTTGAGCGCATTGCTCGTGCGCCTTAGAGTTTTAGTTGACCT +GAAAATATTTGAATATTTAGAAATTGAAATTTTGAAACGCAATGATTAAA +ACGGTCAAAAAAGATGTTATTTATACATACGCAACATTTCAAAATTGATA +ACAAATATTTACAGGAACACTTTTTTCCAATAATACGGTGACTAAGGGGG +AGTTTACTGATAGTAACAAATTGGAACGGTACAGGAAGAAAATTTAAAAC +CGGCTCTACCCATTTTAGTGCTACCAGCCGACAACCAAAAAAATCAATCA +GCCGCACACCCTGCTTGGAATGTGACAATCACAGAGTTTTGGAATTTTCC +TAATTTCTAAAATTTAATTTTCTAAAAACTGGGGATTTTTTCTGTAATTT +TTTTTTAATTTTAAATTATTTTTTAGGAACATTTTTTTGAAAATAACTTT +TGTTTGAAAAATTGTTCGCTAAAAGAGTATAAATAAGATCAGGCTTCCGA +AAATGTTTCAAAAAATATTTTTTCACGATTCTTGCAACAAAAAAAAACAA +ATACTGAAAAAAAAATTGTAAGAAATTTATTTTGTTGAACTTTTCAAATC +TACATTTACAACAAAAACAGTTCTTTATAATATTTTAAAATCCAAATAGA +TTCCCAGTAGATTTTGTTTAAATATTCGGAAAACGACCAAACTTTCATTT +TTTGAGTTCTTAAATTAAAAAAAAAATTTTAAATTAAAATTTTTGATTTT +CAGTCTAAAAATTTCAAAAAAGAGCTTTTAGTTCTGTAACTTTTGGAATA +AAAATTCAAAAAAAAATTGGGGGAGCCAAAAACTAACGCCTGCTTGAAAC +CTGCCCGCGAGAACTTGCAAATATTCAATTTTCTCATTTTTATTAATTTG +ATGAGAAAAATTTAGAAATAAAAAAAAATTTGCATAAGGCATCGATTGAG +GCGAAAGGCAGGCGGAGGTAATTTTAAGGCCAGGCTGGCGTTTTAACTTA +GGCTTCCATAGACCTAATATTTTCATACTTGTTGAAATTTCAGAGGTTTG +AAAATTGAACAATTTAGGCCCAAAACCTTTGTTCCTACAGTACTACAAAA +ATTCTTTGAAAAATTCCGGTAATAATAATTGGAGGAGGAGGAAAAATATA +AAATGATTCTTCGTCAGACAGAAATAAATTGGTGAAGAGAAAAAAATGAA +TTGAGAGAAAAAGAGAAAGAAAGACGGAGAGCGTCTTCGAAAGAAGGAAT +CCTCCTGCGCGGGATCGAAAAAATAAGCAGCAGCCGGGAGTGAGAGAGTA +CACTGCACTAGAAAAGATGCAGAGAGATTCACAGAAAATCGGGAGAGACC +CCCCGTATGTCGGTCGAGACTGAACACCTAAGACCTACTTCATATTTCGA +ACCGGTTCATTTTCATTGGCATTCGTATTATTATTAGTTTTGACAGGGGC +AGTCGTCGTAGATGCTATTGTTGTCAGTTTGACGTGATGGCCGTGTCATG +GGAAAAATTCGGCCATCAAAAATCGGGGGGTTCCTGCCACCCTTTGTCTT +CTATGGTCGGAGAGGCGTTTTCTAGGCTACTTATTTTGGTAGAGTAGCTG +TTAATTAAAAATTTCATCAATTTGGTAATAATGTGGCTGCAAATCATATT +TAAATTTTCTATACAGTCAGTGCCACCCAATTAAAAATTTTCTGGCAGTG +CCACCCAGAAAAAAAAAATATCCTAGGCCACCAATTTTTAAGATCATTAA +TTTTTTGGCTATCAAATTAAGTAGACCACTAAAATGTTTCGTCATTAAAA +TTTTCTAGGCCACCAATTTTGCTTGACTACTAACCTTCTTGGCCATCACA +ATTTCTAGGCCACTAATTTTTTTTCTAGGCCACTAATTTTCTAGGCCACT +AACAAACTGTTCAGGCCATAAAGTTTTCTAGGTCCCTATTTTTAGGTCTT +CAATTTTTTCAGGCCACCAAAATTCTATTCCAACATTTCTCCGTCACCAA +AGTTTCTAAGGCCTTTAATTTTATAGACGACTTCTTAATTGTAAGTCAAA +TTGTTTCAAAACGATTATTTTCAATACATATCAAAAACCCAAAATTTTTC +AAAAACTTAGTAAACTAAACTAAATTTCCAATACGTGCTTCATTTTTATA +TGTAGGCGTTTAGACACCCCAGTGGGCAGCAGTAATTGTTAATTCTTATG +ATTATCTCATTGGTACACTTTTCTTGTTCAACTTTAATTATTTATTTTTG +AAAAGGATTATCATTGGCATTGGCAAATAAATAAAATTGTTAGTGACGTG +GTGATATTGGACATTTTTTGATTTTAGTTTGCTTTTTGAAATTTCAATTT +TCGGCACTTTGAAATGTTCAAAATGTTCATTTGTATAGCAAATTATTTTA +TTAAAATTTTTTTCAAATTTATTACATTTTCAGTGAAAATTGCACAATTT +TTTAAAACTTTCTAAAAACTGCAAAAAAATAATTAGGTTTAAATAATCAA +ATCAATAATTTTTTAAAGGATTAAAATAAAATTATAGTTATTACAAATTA +TTTAAAAGATGTATACTTAAAAACTACTATTTATGTTTTGATTTTTACTC +GAAAATCCAGAAATTTTAAGTTTTCGAGAAAACTTTTTAAATTTGTTTTT +AAAAGAGGTTTATATAAATATAATGAACCCAAACTTGAAAGTGCGAAAAT +GTACTTAAAAGAGTCCAAAATAAGCAAATATCATCACGAAAAGCTCCGAA +CGTTTTTAAGTTTTTCGAAATGTTCAGTTATAGTTTTGGTAAACTGCCAA +CTTTACGAAAAATTCGGGTTTAATTTTCAATGTTTTTATACAAATATTTA +AAACAGAGTAATAGTATAAAATTTGTAAAAAAAAATTTTTTGGTCGGTAT +TTAAAAATGGTGATAGGTGATAGGGCCATTTTTGACAGTAAAAAAAACTT +TTATAATTGTTTTACATTTTACCAACATAGGAGCTGCCTTAAAAAATATC +TAAAGGCTTGGGGTTTTGCCCTACAGTCCCAAACTACCAAATATAAATGT +AAAATTTTTATAAAAATGTTCAAAATTTTTAATGATTAAAAAAATTTGCG +AAACTTAATCAAAATGCCGAATAATTGTTTCATTCCCGCGATTTTTTAAT +AATAATTTTTTTGTATAATTTTTGCATTTAGTGGCGTCATTTGTTTACAT +GTTGTGTTTTTCGGCAATATTAATAGAGGTTTTCAGAGATTTTCTAGTTT +TTGAAGCACATTTTGCCTTGTTCCCGTAAAGAAAACTTGATAATTGGAAA +GAAATTTGGCAAAACGGCGAAATTGACCAAATTGACCAAAAAAGTTAACA +AACTGTATTTAAAAATAAATTATTAAGCAAAGTAAAAACAAAGAAAACCC +ACATAAATGTCAAAAATGACGTCACTCATTTGAGCTGAAATTCAAAAAAG +AATTCGGTCCTTCTTTTTTTTTTTCAAAACAAATTTTTCTTAAATCATAA +AAAACATATTATAATTTTATGACTTTTCTGACAGTTATATTTGGAATAGT +GGGACATTTACAAGGGAAGTCGAAAAACTGAACTCCGGACTTTGACATGC +TATAGTTATTTTTCGATAAAAGAGTGAAAATAATGATCCCTCCAAAAAAT +TTTGCTGCCGCGGACCAGGTTCAGCAAAGTTATGACGTTTTGAAAGTGCC +GAAAAAAATTCCTTGACCAACCCAAGCAAAAAAAAACTTTCAAATTTTCA +AAAAAAAAATTCTGAAAGTTGATAAAAACTATTGTAACTTATTCAAAAAT +GTGAAAAACGTATATCATGCACGTTTTTTCTCCCCACGGACAAAAAACCA +CATTGCTTGATCAAAATATCTTGAGCAAAATTCTAAAAATTACTTTTTCT +TGTAGATTCATTTATTGGTTTTCTTCAGAGTTATGAGCTAAAACTTGCAT +GGCATATGTTTTTCACTGTTTTGAATAATTTACAAATATTTTTTCCTCTT +TTCAGAATTTTTTTTTTGAAATTTTTGAAATTTTTTAAAAGGGTGTTTCA +GCCACTTTCAAAACGTCATAACTTTGCTGAAGCTGGCCCGCGGCAGCTAA +ATTTTTTTGGAGAGATCGTTATTTTCACTCTTTTATTGAAAAATTACTAT +GACATGTCAAAGTCCGGAGTTCAGTTTTTCGACTTCCCTTGTTAGGGCAA +AAAATACCCACAGACGGTACTCCGCCTAAAATCAAAAAAGTTCCAGCAAC +TCGAGATCACTTTTTTACCATCTCAAATCGTTCGGTTTGTTGGGGGGGGG +GGGGGGGGGGCTTAAAGAAAAACGAAAAAATGAGACACTTGTTAATTTGA +TGGTAACAAGTGAAATGGAGAGAGAAAGAGAGTGTAAATACAAGAAGGGA +ACAAACACTTGAAAATCAAAATTGTCGGAAGGAACTAGGGGGAGGATAAA +ATATTGGAAATTAGGTTTAATAGGATATGTATCTAATCCCGAAGAATATT +ATTAAAATAATCGGTTCAAAGAATCTGAAAAAATCGATAAATGCGTTGTG +TTGTCCTACTTCCGTCCTCTACACAACGTCGTCTTCTTCTTCAGGGCGCA +TTCTTTTGTGTAACAGTGCCCCTTTTCTCTCTTGATGCCACAAAACACTT +TGGCAGTTACGCAATCGAAAGGCGAGGAAAGCAAAACGGGTATCAGATGA +TGATTAAGTGAAACTGGAACTGATAAGTGAGATGGATTGAAATACAGATA +GCCGTAAACTTTTAATAACCTAGAATTTTAGTTATTAAAGGTGTTATGTA +TGTTTCGAAATTTGAAAAGATTTTCTCAATTTTTGAATGAATTATGTTTG +AAGTAATTTAAAATGCCGAATGAAGGGTTTCAATTTTTGTTTTTTTAAAA +AGATTTTTCGTCCGGCCGATTTTTCGCAAAATGTTTTTTAAAATTTGGGT +TTATGTTCTTCTCTTTTTTCATGCCTAAGCCTAAGCTAGGCTTAGGTTTA +GGCTTACTAATCCTAATCCGAAGCATAAGCTTAATCCTAAGCCTAAACCT +CTCCTACTCTTTTAAGCTTAATGAATGCCCTAGCTTCATTTTTTTCATTT +TTCGCAGGTTTTTTTCTCAAAAACTCAAAAGCGATGCTACGAACACCAAA +AATTGGTGGTTCAAAATGTGTGTTTCTATTTTTTTCAAAATTTATTTGAC +TATACAAACCAGCTGACAATTTTCTTCAAAATTCCGTTTTTCTTATCAAA +AATAGTCAATTTTTCATCTAGAAACTTCAAAAAACCGTTACCGTTTCCCT +AAGTTTTGCTATCAGTTCCGTAAATCTTGTACCTTATGTCACATGGCATT +AGAAATATTTCAATTGAACCAATCTTGTTCGCGTGGAGTACAAGTTAAAC +ATTTATGATATGTGGATGGGTGCAATTGCGCTCTATTGAACAAACTATGT +ATCAACAGAACGCGTTAACATTATTTGTACAGGTGGGGAAAAACAGGAAA +AACGACTAGGCAAAACAAAAAGTATATAAGTTTTCTTCTACACGTCTCAT +AAAGGAAATTCAAATTTTTTAGAAAAAGAGCGGGGGGGCGCGATTGCAAA +GGTTTAGACGGCGTTAAGATCTTTGTCGACGAGTGGTTCAGCCGCTGAGA +ATGTGATTGCCGCCGGAATATTGTCCTTCTCGTTGATTGAGTCTTTCGAG +AAGAGCGCCAGAATGACGGGCAGAATGAAGAGACCGTGGAGGAGACCTGG +GAGAATTTTAAAATTTTTGAGTTTCTAGGCCACGAGTGACGTCACTATTA +TGTCCAAGAAGATATTCTAAGGACAAATTTGATGATTGTTCACTACTTTT +TCACTAAAAATCAGCTTGAATCGTAGAAAACAAAGAACTTTCAGAAAATT +TCAGCGCTCACCAATAGCAACGACCAAAAAAACGGTCTTAGCAAAGCACA +CGATTGCATAAGTTGGCACAAAAATCAACGGAAGCATGCATAGGAATGTC +GACAGTCCGGCTTCACACATTGGCATTGCCATTTCTGCCAGACTACTGTA +GACACGTTCTTGTGGAGTGCCACGTGCACGAAAAAAGTTGTAGGCCACGT +GAGCGGTGTAGTCGACCGAGAATCCCGTGGCGAGAAGGACGTCCACTTGG +ATTACCGGGTCCAGGTCGGCACCCCAAAGGGAGAGACCACCGACGAGAAC +TGTAAAAACGATTTTAAAAAAAAGTAACTTTTTCAGATTAAATCCAAGAA +AAAAACATAATTAAAATTTGTTTCAATGGTTTTTTAAAGTGACAATTACT +CATTTTCAGGTTTTAAAAACTTTAACTTGAAAAAAAAAAACATTTTGAGC +TACTTTTGAAAAAGGTTCTATTTTGAATTTCCCATCCAAACTTTTTGAAA +AAATACAAATGATAAAAATAATTGCTTTCTTAAAAAAAAATTGTTAGCAA +CCCTACCGTTCGCTAAAGATCGTTGTCGTTTTTTCTCAGAAAATTTAAAT +ATCCCGCCATATATATTTTCGGAGAATTTCAATTTCTCGAAAAATTGTTT +TCTCTGAAAATTTGAATTTTCCGCCAATAATTTTTCTCAGAAAATTTGAA +AAAAAGGATTAAAAACATGAATTTTCCGCAAAAAATGTTTTCTCAGAGAA +TATGAATGTCCCGCCAAATATATTTTCAGATAATTTTAAAGTCTCGCCAA +AACGTTTTCTTCGAACATTTTAGGATTATGTGTTGAATTTGTAGAATTTT +GATCTTGATTTAAATTTTTTCAGTTTTCAATTGAAAAAAAACTAACCATA +ACAGATACTTGCAATAACAGATGTAATCACAGCAACTGCATTAAAATTTG +CAATAAACACAAAACAAACGATTGCCATACAGACTACCGTAACCGCAATC +GATCCAATTAAGTCAGTGCCAACAGTCAGGATGATACTGAGAATTGCAGA +GTCACAGTCAAAGAGTGTAGCGTTGAATTGACTTTCTTCATGAAGAATTG +TTCGGATATGTTGCATTGCACGTGCTCTTTCTGCCCATTCAGACATTCCT +TTACCGAGAAGTGTCAGACGGAACGCTGTGACAATTGTTCTGAAAATTTG +GAAATTATTCGGATTGAAATTGAAAAGTGTATAGGAATTAAGTTTGAACT +ATTTGAGAAGTTTGTATTTTAAATTTTGCGCTAAGTTGCCTGAAAAAAAA +CTAATTTCGAACTATATACCTACAAATATTTTTCAAAGAGCTCAATATTT +GAATTTCGCGCCTAAAATATTTCGAAAACTTAAAATTTGCGACAAAACTA +TTTAAACTATTTGAGAAATTTGAACTTTTAATTAACATTTGAACTTTGCG +CCAATTTTTTTTTGGAAAATATTAAACTTTTGAAATTCTAGTTGAAAGGA +AATTCAGAAAAATTGAGGATGTAATTTTTTTATATGAAAAACTTTTAGAT +TCGATTTCGCGTCGAAAATTTTTGAATTGTCAAAATTTAAATTTTGACTT +TTGCAAAAAAATGGCGGGAAAGTGAAGTTTCATTAGGAAATTCAAATTTG +ATAGGCGTTTGACTAACTTATTATCATCTCCCATGTGATATTTTACAAGT +GGAGGGTTCCCGATCGCATCCATCCACGTCGGAAGATTATCATAAGATGG +GCGGTATTTTTCTCCAACCAGAGTGGATAAAATATTCATCGTCTTATCAA +AATTCACATATTGCGGAAGAAAAATCAGACTTCGATTGTCTCCACGAATA +CCTGGCACGTGCTCGAGCCGATCCATCATATTGTTGAAAGAGTCGTACTG +AAAATTGAATGGCCTAGTAAGTAAAAATTAGATCATGAACTTACCTCTGC +TTTGATCTCGATATTTGGAGGGTTGTTCACTATTACTGTAATAGGAAAGT +AACGGTTGAAGACTGGCCTGAAAAATGATAAATGCTCAAAAAATACAACT +TTTTTCTTTTAATAACGTAAAAAGTTTTTTAAATCGATAAAATCAATAAA +TCGGCATTTCAACTGTAAACCAAAAATAACAATTATTGATTTTTCTTACA +AAGACCTTAAAAATAAAAAAAAATCAATAAAAATAGCGATTATCTTTCCA +AAAATCTGAAAATCAATTCAAATAATTTTCTTGATCTTTTATGTTAACCT +ATAAATACCAATTATTGATTGTCTGGAAAATCAGTAAAGATTATTGATTT +TTTTGAGAACCTAAAAATCAATAAAACCCAATAAAAAAGTAATGTTTTTT +CAAACGCTTTTTCAAACAAATTCTTGATTTTACTTTCAAAAAACCAACTT +AATATTCGACAACGAATCCACCAGCTTCGAATTTGATGGGAATGCCTTTG +CAGGTTCAAAGGTCGTTTTCATGGTGACTACTCCATAAGTTGTCAACGCA +TACATCCCAAGGAGCACCATAATGCACGCTACACGCCCCTTCACGGAGCA +CACGAAGCTCGAGTACTTGGAGAGCCACGTGTCGGCTCGGGAAATTTTTG +GCTCCGTCTCATTGGCGATGGATTTGTAATCTGGGTCGTTGCAGAGGAAT +ACAATTGGAGCTAGGATCGTATAGGTGAAGATGTAGTCGAGGAGCAAGGC +GAGCGAGGCAGTTAGGCAGAACAAGGACATCTGGAAGAAGAGTTTTATTC +AAGCTAGCCCACGTTTTCAAAAACTGGGCTACGTGCCAAAAAAGGTTACC +TGAGGCGTTGGCGTCAAGAATCCGATTCCAAAAGCAATAATATTGGTAAG +TGAGGTGATTGTAATCGATGGTCCAACATCGACAATCACTTGTTCCAAAC +GGCGAGGTCTGAAAATTGCAATTTCACGATGCTTTTACAATACCCCTACA +GTACTTTTGCAGTTTCTCTACAGCACCCCTGTACAACTACGGTACTTTTA +TTTATTTATATATTTGTTCATCAGGCAACAATCATAATGATACAATTACA +ACAAGGCAGTGAACTTTTACAATACAATGCCCCACCCTCTTTTTCCGTGA +AAACTTACGTGTCAGTAATTGCAATATGATGTTTCCATCTGTGAAGTAGA +ATAAAAGCATCATCAACTCCAATTCCAAGTACCAAAAACGGCGTAACACA +TTGAATAGAGAACGACGGGAAGCCCATCCAACAAATTGCTCCAAACGAGG +CGACAGTTGCAGCCATCGGAGTGAGCAATGATGTGGCAACCAGATAGAAT +GCCATTTTGACAGATGACAGGCGGACAATGACAATGATGACCTGAGTCAG +AAGTAGGAAGAATCCGATTGTCATTAGAGTGGTAGCTTCAATGGCTCCTC +GAATCATTTCACGATTTGCTACTTGGTCACTGAAGATGGTGAACTGAACG +TGCTCGAAGGCAGAGGAGTTTTTGGAAAGTTGGAAGAGCTCGTCGATTGC +GTCCTGGGAAAAGTATAATTAGGAAATGCCGAGTGCTTGCCAGTTTTTTT +TATTATGTAAATTTGCTTCCCAGAATCGCGAAAATTTGATTTCCCGCAGA +AAAGACTGAAATTTAAATTTCTACTAAAAATTGTTCAGATGTTTGTTTTT +AGAAATTTTCTTTAAAGACAAAGATTTGAATTTCCTATTGAAAATAGGTG +AAAATTCAAATTTACTACAAAAAAATTGAGTTTTGTTAAAAACACACTGA +AAAATTGAACTTCCTGATTAAAATTGATTGAAAAATTAGAGGCTCCTAAA +AAATATTGAAAACTCGAAATGTAAATTCAAATTTCCCGTCCAAAAATTGA +CAAAAATATTTGAACTTTCTGCCAGAAACAAGTTAAAAAATCAAAGGTTC +CTCTAATAGTAAAACTGACTCAAAATTAATTGAAAATTGATCAAAAAGCC +GTATGAGTCTTCTAGGCTATTCTCACCTTAAACGCCAATTTTCCTTCTGG +AGTATCAGACCTCGAAAAATACCACAGCACCAAGGATTTGGAGCTGATCC +TCTCGGTCGGTGGTTCTGAAAGTTTCAATATTTTTTCACATTTTTCCAGA +ACTTTTTATAGTTAAAAAAATGAAATTTTAACTGGAAAGTGGCTAAATCA +TAAAAACTATTTTTCAACTTTTCATTTAACATTTCAAAAAAAATCTTACC +AAAATCCGCATTACTCAAGTGAAGTCCCAGGAAAATATCCAGTCCGCTAT +ATGGCATATCCGGATAGGTGAATACACTTGTGGTACCATTGTTTCTCCGC +GTCAAATTCTGAAAATTGCCATGTGGTCGTTGAAGAGTTTTCTAGTCCAC +CACCACCACCACCAAGGGTTTCGGTTTTTCGACTTTTTAGAAAATCGAAA +AATCGAACAATTTTTGAGAAAAACTTACAAAAAGCTGATAATGTTTTTAT +TTTAACTTTTTTCTCCATCATTCATTTTAAGAATATAGATAAATGGGATA +AGACCGTCCAGGTTTCTGTTCAGTTTTCCCTGTTGTTAAATTCATTAAGA +TGTTTGGTCCCCAAAAAACAATGTTTCTTTCATTTTTCGATTTTCAATTT +TTAGATTTTTCGATTTTCACTAAAAACATCGAATAATTGAAAAAATCGAA +AAATGACACCCTAGACCACCACCTACCGCTAACAAGTGAAAGGGGCTGTT +CAAGTCGCAGAGTGGATCGCAATTTTTTCGTCCATCCCCATCTTGGTAGC +CAACTGCCGCCGATAGTCGATTGTCCACAGTATAAATCTGAAATTTTTTA +AATTCCCGCCAGAAAAGTGGGCGTGACGGAGAATCAACTTACGTCTGCCA +GTGCGCCTTCCTGGAGAATACTGGAATTTTCGCGCTTGGCGGTAAAAATA +CAGAATGCTCGTTCCGGATAGATGTCGAGTCCGTAGTATTCCAGCCAGAC +ACGGGTTTCACTGAAAAATGTAAAAAAATTTATAGAAATTTCCGCAAAAA +GCATATATTTAAAATAGGAGTTTTAAAAAAATTAACAAAATAGTTACGAA +CGAAATTTTCATTTGCTTTAAAGTTTTCTTTTTTTTCTTATTTATTTTTG +ATCAAATATTTATTTTGGGTTTTTTAACTTCAAGTGGAATTCCAAAAAAA +TTCAATTTTCTTCCCAGTCAACCAAACATTGACCAAATCACAATAAGAAA +GGGAGAAAGGGAAATCGAATTAGAAAAAGAAAAACATTGCGAAAAAACGT +GTTATTTCTGACTGGTGGAGGAAGGAGGCTTCAAGGTCAGTAGTCACTTA +CTATCCAGCATCTGAATCATCCGGTGAAAAGGCTTTGCGAATATCTGGCT +CTAAACGAATGTGCACAAGTCCTGAACTGAGAACTAGGATGGATAAGATG +CTCACTGAAAATTGTCCAACTTGAAAAATTTCGATTTTTTATGTTTATTA +AATTTTTTCTGGTGTAAAATAGCAGAAAATGCCAAAAAAAAATGTATCAG +ACACAACTTTTTTTCAATTTTTCAAACTTTTCGTTGCAAGACCAAACATA +CAATAACAATTGTCGTTCGAGCGCGTTTTGCCCATGCACCCTTAACGGAG +ATTTTCATCGACTACTCTATAGAGCGCGTTGGTGATTTTGAAAATGAATT +TTTCTTGGAAATTTAAAACTTTTAGAAAGGGATTTTTCTATTTTTTCCAA +AAAATTATATTGAAAAATCAATAAATTAATTATTGATTTTTCAAAACTAT +AGTGATTCTGATTTGAAAAATGAAAAACATTGCTTTTAAAATTATCTGAA +CTCAGTTTTCACGAAAAATCAATAAATCGGTAATCGAAAAACATTCATTT +TTCTATTTTTCTCAATTTTTCGATGTATTTTCCAAGAAAATCGATTAATT +TATCGATTTTTTTTCCAGAATATCTGATCGATTTTTTTATTCATCGGAAA +AGTTCAATTATTTTATTTTTAGGAAATTGTTTTCCAAACTTATATTGGTG +GCCAAGTTTTCCCATTTCGACGACCATAAAGTTACAAAAAACTCACAAAG +TATCGAATAAACCGGATAGGCGGCTAACAGCCGTGCCACGACGGCACTAA +TCACATCCCATCCCATGTGCTGAAAAACTTCGAAATTTTTTTAATATTTC +AGAATTTAAAGCAGCATGCAAACGCGCTCCAACAAAGAAAAATGTTTTTA +AAAAATTGAAATTCAAAACACAAGCACGTGAAGCAGAGAATGCAGAAAAC +AAGACCACTGTCACAAAATTGTAGAAGTGAGGGAGGGAGGGCTATTGCAG +AGGTGACCAACGGGTTTCGGTTTCCAATTTTTCGGACACGGCGCAGAGGA +TTTGAGTCATTATTATTGTGTTTAGAGAGTGTAAGAGAATTAGAGAATTA +GGGATAGATGGGAAACTGTACGTACTTCTGCGAAATGGTGCACTTTTAGG +ATCGGCGGCCTAGAAATTTACATGGTGCTCTAGAAGTCTAATAGATAGCC +TAGATCTTTTTAAGTCCAGAAAATTACTTGGTGGTCTAGAAGTTTTTTTT +GTGACCTAGAAATGCAGTTGGTGGACTATAAATTCACTTGGTGGCCTAGA +AATTCATTTGGTAGCCTAGAAATGTACTTGGTGGCCTAGAAATTAACCTT +GAAGCTTAGAAGTTTGTTTGAAAGCCCAGAAATTCACTTGATTGCCTATG +AATTCACTTGGTGGTCGAGAAATGTTCGTGAAAGCCCAGATATTTACTTG +GTGGTCTAAAACATTTTTCAGTTCAGAAATACATTGGAAAAAATTTCGAT +TGAGAATTATGGCGTGGGATTTCAAGTGGTGACCTAGAAATTTGTCAAGG +GACTGAGGAATTCATTTGGCGTCTGGAAATTTTTTTGGTGACCTAGAAAT +TTATTTGGTGACCTGAAAATTCATTTCATGACCAGTGAATTTACTTGGTG +GTCTAAAAAGTCTCATGGTGCCGGTCTTAAAGTCTCATGTGTTGCAAAAA +TTATACTACAATATTTAACTTTGAAATAAAAATTCAGCGGGTCTAGATTT +GCAAGAAAAATCTGTATTTTCTCAATTTTTTTCAGGTTTTTGATTAGTTA +AAAAAAATCGAAATGATTGTTTAGAACTGCAGAGAAAAAACAATTTTGTA +TCTCCGGAATGCGCTATTCTGGGGAGTCAGATTTACTGGATTTTACTTTT +TTTCCTGCAATTCCAATGCAAAATAAGGTAAAAAAATGAGAAAACTGGCG +GAACACGGCGGTACACACAGGGGCAACTTGAATGTAAGGCAGGTGTTTAG +TAAGTGGACCGAGGGGACGGCAAAAGCTGGTATTTTTCCTGTGTCGATGG +GGGACAGTAGTAGCACACAAGAAACAAGTATTTTGATGATAATACGAATA +AGAAAAAGAAAAAGGCAGCAAAAAAGTGTGTGGCAGACCACCACCGTCCA +TCGGATTAGGGAGCGGAGGCAAACTCGCTCTACCGAACAGAGGGGTGTCC +GTTTCCCCCAAAATCCTCTGAATGTGACGTCATTGTTGGGGCGGCGGGGC +GGCGTCCAAAAATTAGTGATTTTTTTTTTGGTATTTTGGAAAAAAAGGAA +AAAATCGAGAAACATTTTTTTGTGTTTTTGGGGAGTTTGTCATGTGAAAT +TTGAAAATGTTGGGTACAATCAAAAAATTGTTTTGGTTTTTATAATTTTA +ATAGGAATTTTTAAAAATCTGAATCGTTTTTCTTTGAAAAATCAAAAAAC +AACAAAACATCCGCTTTTTTTAAAAATTGTTTGTTAAAAAAATAGAAATC +GGAAAACAAAATTTTCCGATCTTCTCGAAATTCACAAACTCATAAAAAAA +TCGAAATCCCCTTGTACCCCACCCTAGTTCACTGAAGCGCGTTTGCTTTC +TGGCCAAAGGCATGGAGGGAGGCGGGCACCTCCCTTTTGCAAAATTGACC +TAAATAAAGGTGATATGCCAGTGATAAGGAACGGTTTAATGATCCGAAAC +CGCCAAAAGTGCATAGTTTCTGCGTTAAAAAAAGTGACAACTGACATCAC +ACGGAGGCTACAAAAGGGGACTCACAAGTTTGCCGGAGAGGAATGAAAAT +TGGAAATTTGTACGGGTAAGGGGATCAATGTTCAGTGGTGGTCGCGAGGG +AGGACGGAGGGAAAAAGTGGAATTAGAATTGAATGGGAAATTGGTGGCAA +AACGGTAAACACTTCTTATTATCCAAATGCATGAGGGATGGAGAAAACTG +GAAACCTTTGCAGAATTTTGGAGGGGGTGATGAAAAGTATTGGCAACACC +TTGGTGGCCGAGAATTTTAAATTGATGATCTGGACTAAAAATTCAGATGA +TGGCCGAGTTTTTCATATTCGCACCAATACAAATGATGGCCTAGAAAGTT +TGGAGCGACCTAATTTTTCAAATTTACAAATAGATCTTTAATGTTTCATC +GACAAGGGATGTGAACTAGAAATTAAGATGGTGGCCTAGAATTATATTTA +TGGTTCGTCAAGAGGTGGCCTAACTCTTCAAATTCACGAAATATTCTAAA +GTTTAAATTTCCTTTAATTAGTATTGTGGACTAAAAGTCGAGATAATGAC +CGAACTTTTCATAAGCTCTCCACATCAATTGGTGGCCTTGAAATTCCGAC +ATGGCCGAATTTTCGTAAGTCGACCCCAGTGGTGGCCGAGCCAAAAAACA +TAATTCCGCAAACTCTTACATTTTAATATATGAGGGAAGCCAGAAGTGCG +TGCCACATTATTTTTACATTTTTGACTATCGTGCCAAAATTCCAAAATCC +TCAAAAATTTGAATTTCGCGGCACAATTTCGGGTTTTGAATATCTTTTTT +TTAGTGTGATGTAGGGCGTACTTTCCAATTTGCATAAAATAAAAAATCAA +CAAAAAGCCATACATAATGTCAAATGGTCAGTTGCAAAGAAAACAAACCT +GCGGTCAGGATGGCCGAACCAGAAAAATCAATTCAAGCTTTCGATTTCGC +CCGAAAAAAATGAGGATCAGAATAAGAAGGTGTCGCCTATTAGAGATTGG +AGGATGTTGAGAAAAAGAGAATAGTGGAGGAAAATGATGAGGTAGAACGG +AATTGAACATGCAAATAAAATGAATGTATTGGGTAGGAGAGGGAAGGTAA +CACTGTGTGTTCTGTGTTTGGAAAAGGATTGAAGTGGTGGACAAAAGGAC +TCTTGGTTTAATACTACTTGCCTGTTCTGATCAGGTTCAGAGGTATTTCA +GCAATAGCTTTTGTATTTTGCATTTTGTCTTTTTAAGTACTATTATTTAT +CAAATCCTTTTTTGTAACTTTGAATCTGATGTCAAACTTGTGGAAAGTTT +GAACTCGAAGAAATTGCTCAAAAAGTAAAATTTGCGCCCAATTTTTCGAA +TTTTTTTCGTTGTTTCTTTTTAATTTCAAAACACAAATCTTCGCCAAAAC +ATTGTTACAAAATTAACATTTTAATTTTTAAACAGCTGCTAAAGCACTAC +AAATGTGAAATTGATGCCTAAAATTGGAGAAAAATGGAGTTTTTCAAAAA +AAATTGAAATAAGAAAGTTTGGAAACTAAATGTCTATATATGGGGAAAAT +GCTATTTCGAATCTCGCGTTTTTTTAAGTTGGGCATCTCCAAAATATGAA +AAAAATACAAAAAAAAACTCCAAAAGATAATGTTGAATTTTTTCAAAACC +CTCACCAAGAAGTATGTTTTAATAAACAAAAATTTGAATTTCTTTTCGAA +TTTTTTTCAAAATTCGTAATATAAGATACCTGTCACACTTATTTTCAAGC +TAACAGGAAAAAATAAATGTTGAACTTTATTTAATGATAAAAATAGTTTG +TAGAAAATTCGTAAATTTAAAAAAATTCAAATTCTACCAAAATATATTAG +TTTTTCACCTGGAACTAAAAACATTTGAAGAATTTTTTTTAGCTTATATA +ACACTACAACCGCAACACATTTTTGTGAGAACATGTCTAGCCTCTGTCAA +ACAGTTTTCCGGTATCTTCGTGTGTGTGTTTGCTAGTGTTCAATAGATCT +TCCTGTAAAAAATCGAAAATTTCCGATTATATGCTTTTTATGTGTTTGAT +TCTATAAGCGTTTAGATTGTTATCAGATGATTTGACATTATTCGCAACAA +TTTTTTTAAATCCGAATGTTTTTCGAATTTCTATTTTTTATAATTTTCCA +GACAGTTTAAGAGCAAAGTTGAAGTTATTTTTTCCTATCAAAAAATGCAG +GAATAAATACTACCTCAATTTTTGCAAGAAAAAAAATTTACAGTAGTTTT +TTTGCTGGAAACTAAATTCCGCAGAATTTGAAAAATACTGAAAGGGTTTT +TTTCCTTTTTTAATTTGTACTCCCTACAGTACCCCTTATTTTTGAATTAC +AATTTGATGTTCGTACCTAAAATTGACACTTTTTCTCTAGTATATTTCCG +AATTCAATTCATAATTATCAGTTGAAACTAGACCCCACCAAAATCACAAA +TTGATAAGAAAACGTAGAAAGGGGAAAGCACGTGTAGCCTACAACAATAT +TAACTGTTTTCAATTTATTATTTTTATTTTCCAAGGGTTTTATTCTTAAT +TCTATTCACAATTTTTCGAAAAATATTCAGCAAAAAAGTATGCTTTCTGA +CTATATTATCAGTATAAAGTGAGTTTTTTGTGAGCATTAAAAAAATCAAT +TTTTTGTGGCCTAGCTTTGCATTTAGTGGCCTAAAAAATTAAATGCATTT +CTTCCACGTTTTCCGTAAAAAAGACAGTGGAAGAGTTTTTATCCGTACTT +GGGCAGGCTTAATATTTTGTGGCCAAATTTTTCGCGTGGTGCCTAGAAAC +TTTTTTTACGTTTTTTCTCGGAAACTTATTTTTTTCCATGGCCGTGAACG +AGTTTTGTTTAAATTTCAGGTCGCTTTCAATATTTTGATGACTAGTTTTT +TAAAAAATATTTTCCTGCTTTTAGTAATGCTTGGCCAAACGTCTTCACGT +GGTCGAGCTTTTCATTTGATGCCCTAGGATTTTTAACCTGTCGTTCTCTA +GACAATAACTACCGTGGACTCGAAAGTTCTACGCCACGTTTTAAATATTT +GTAGCCTAGAAATCAAAGTCACTTCCCGAGTGGCCTACGTTTCCCTGAGC +ATAACTAGTCCTCGAGAAGTCCAGTCGACCGTTACTGTCTACAAGATTAT +CGGCAAGATAATCCGTTTCGATTTCGATGTCCACTCATTCACTAGTCGTT +TTGTCGTCGTTGCAACAATGTGGAAATTACTAAATTTTGGCATTTTTAAA +GATTTTTAAACACATTTTTTCTGTCGGAAACTGAGAACCGCAGTTTGTAG +AGAAAAAAATTGCATTTACTTTCCTGATTGAAAAATCTTTGTTAGCGTTC +TTCCCCGCTGATTTATGTACCGTTTAAGTTTCAGCTGAGAGACAGCGTGG +GATTGGGGGAGACGCAGACAGCGAGTGAGTTTGCGTCTCCCTCTCCCTCC +CACTCTCTCATTTGCAAGTTTTGAGTTTTCATAACTCGGAGAGTGGAGCT +ATCGAAAAATTCAAAAAAAAAAACAAAAAATTAAAATAAAAAAATTCTAC +AAATTTTTAGTTGCTAATTTTTTGATAGCGCTGCTAGGTTTTGAGATAAT +GACGTTTTTAACTCTACCTCGACTTTTTGTGTGTTACCAAGTTAGTATTC +CTCTGACAAACCGCATGACCTCACCTCATTGTAGCCTCTTTCGAAATCTG +TAAACTTTACAACTCATGTTTCCTAGTGATATCCGCCTCCATCTCAGCTG +TTCTCTTTCCATCTTCTCCTAACTGTTTTCGTCTATTTTAAAAATGAGAT +TATTCGGATTTCTTACTAGTTCCGCTCAAAAACCAATAAATTTATTTTGT +AGAGCGAAAAATTCTACACATTTTTGTAGTCAACAAGTTTTTCAATGCAC +CTCTCCTCGCTGAGTTTTTAAGATCTATAATTTGATAGTAAAAATATTTT +TGACAGTAGCTTTTGTTTTAGAGATAATCAGGATTTCGCAAGCCACGGAC +TTCAGTCTAGCCTCATTTCGAAAGTTGTGAACTCTGCAAGTCATGTTGAC +TAATAGTATCCCTCTCCAGCTGTTCTTTCTCCTCCTTCACTCAAGTGGTG +ATCGTTTTCTCACTTCTCTCGCTTTTTCGCCCCTCTCTGTAGTGTCCAGA +GAGTATCAGTTATGTCTCCAGGACGCCGTGTGACGTCATCGCTGACAAGC +CGTAGCCTACAGCGCCCGGCAGAAGACCTGTTTTGACATGCCATTCGTGA +AAAATTTAGATTAGCCCTCTCACACTCTACATGTCTCCATGTTTTTTCAC +ACAAACTATTTTTTTGAAGAAATATCTTTAAAACTTTGCTTTGTCTATAA +TTGATAGCATAAAAGGTCCAATTTTTTCCGTAGCTCAGCAAATGGCGTAA +CTAAATGGTGTGAAATGTTTGATAGGGGACCGGTTTTTGGCTGAAATCTC +AGAAAAAATGGAGCCCTGCCTGCATAGAGACCCCTTTCGACTGATGACGT +CACAGAGTAAGGTGTCACATCACACCATTCTTATTTCTCTATTTGAGGTC +CAATTAGACTAGGGGGTCAGCGTGCTCTCGATTCCTAGCCGATGACGTCA +CATATTTGCCATTCACAACTTTCTAAACTTCAAACATTTTTTAATTTTTC +CCAAATTTCAGCCGATTCCTAATGGGAGGATTCCTCTCCAAACATCACCA +CCTCACTGCAGTCCACGATGCCACGTGTGGCCCAATAAAAGGTGTCGGAT +ATGAGCAAGTAGGTCATAAATTGAGCTCTCACTAAGTTAAGATGAAAGAA +AATTATTTAGGAAGACGGTTCAGTGGTGGAGGGGTTCCTTGGAATCCCGT +ACGCCGAGCCACCAATTGGAGCCTTGCGCTTTAAGAAGCCAGTTGCTCAT +CGGAAATGGACGGAGCCGCTGGATTGTGTTAGGTTCGGGCCAAGGAGTCC +GCAAAATGATGAGCTACTAGGGCAGGTGAGGCGCCTAAATCAGAGCAAAA +CTCTGTCATTTTTATAATGTTCAGTTTGTGAACACAGTCGGGAAAAGTGA +GGAGCACTGTCTCAGCCTGAACGTATTCACTCCAAAGTGGGAGTCAAATG +AATGGCCCGACGGCTTCCCAGTGATGGTCTTCATCCATGGCGGAGGCTTC +GCTGTTCACTCATCCAGCAACTACGGCTGCGCTTCCATCGCACGAAACCT +TTGCACCAAGGACGTCGTCGTCGTGACCATTAACTACCGCCTCGGCGTCC +TTGGATTCTTCACCACCGGCGACGAAGTGTGCCGTGGAAACCTTGGACTT +TGGGATCAGACTGCCGCACTCGAGTGGGTTCAGGAGAACATTCAAAGCTT +CCGAGGCGACCCTGATAATGTTACAATCTTTGGCCAAAGTGCAGGTGGAG +CATCTGTGGATCTGCTTTGCCTATCGCCGCACTCGAGGGGATTGTTCAAT +CGGGCGATTCCGATGGCAGGGAATGGAGAATGTGATTTTGCGATGCGGAC +TAGTGAGCAGCAGGCTCAGTTGTCGAGGGAGTTTGCGAGATACCTTGGAT +GGGAAGGAGATGGTAAGTGATTGAAATGTCGCTTAGTCGTAAGATGTTAG +AAATTGCATTGTCATCAGAGTTGGATTGAGTTTGTTTAAGCGTAATTTTT +ACTAAAGCCCATCGAAGCAGTTCCGTTGGCTACTTGGCCTACCACACTCA +GCCTGGGAGCCCGTCATAGCAAGGCTCAAGACATTTCCTATGTAGTTATT +TCTATTGCAAATTTAATACGGTGAATTTTCCAAAAATCTTGACGTATCCG +AATGAAAAACCAGTGCAAACTTGTTGAGTAATATCCCTAATTACTTCATT +CCAGACAACGACAGTGAAGACCTTCTCCAATTCATCGACCAGCAACCCCT +TTACAAGATCGAGATGGGCATAAACCCGAAAAGAGGATTCAAGCATTCCC +AGGCTGGAAGCTTGTATTTTGTGCCAAACTTTGACGGCGACTTCTTCCCG +AAACCACTTAACCAGCTTAGAAAAGAAGCTCCAAAGATGCAAATAATGAC +AGGAACCACCAAGTACGAGGGTCTATTTTTCAGTGAGTTTAAACTTCTGA +AAATTTTCTGAAAATTTTCTATTATAGTCGCCCTCGGTGCCTTATCGAAA +AATCCGGAAGGAATTAAAAAGTTCATGGGAAGAATCTTTAAAGAATGCGA +CTATGGAGAGCGTGCTGACGATGTGCTGCAGATGGTCTACGACTTTTATT +TCAAGGGGGTACATCCCAAGGATCATGAGAAGAATATGCATCAGATTGTG +AAGGTAGGTGGCATAGAGCCTACAGGGCCATCAGCCAGTGTTTCAGTTCA +TTGGAGACTATTCTATCAACTATGGTACATACCGTCTGGCTAACATTATG +ACGGATCTTCAACACGATGTATACTTCTATCAGTTTGACTATCATAACTC +TGCAGGATTCGGAGTGTTCCGGTGGCTTCTTCCGTTTTTGGGTGAGTTTA +GGCAGGATGGGTCAGATTTTCTAAGCTCTGGGCCACATGCTTTTTGGTAG +ATCAGTTTTAGAAATTCTAAGCTAGAAATGTATGAGTATGGTAAAACTTT +TAAATCAGATTGAAAAGAAATTTTCCAAATTATAGGACTTTGTAAAAACT +CCGATTGCTTAGGCTACTTCATCCGTACGACCGTAACCTGTCACTAACGA +TTCTAATAGTGTACCTTATCTGAACAGTATTGCCGAACTAATTGAAATTA +ATCCTGAGACTCCGAGATTACCTAGCGGTCCCTATCGCTGTGGCCCAGTG +CCCATTTGGCTCAATATCCAATTTTCAGGCTCCACACATTGCACGGAAAT +GAGATATGTGCTCGGCAAAGGAATAATCTCGAAATTCCGACCAAATGATA +ATGATAAGAAGATGCTTCACGTTATGACAACTTATTTTACAAATTTTGCA +AAATATGGGTACTTTTTTTGTGAACACTTTCGAAAAAAATTAAGCTGCTT +TCAGAAACCCTAATGGAGAAAACCAGGAGACTGGAGAATGGCAAAAGCAC +GACTCGGCACACCCGTTCCGCCATTTCAAGATTGATCTGGACGATTCTGA +AATGGTTGAGGACTATCAGGAACGGAGAGCCGAGCTATGGGATAAACTGA +GAGCATTAAATGTTAGCAGGGCTCAGATGTGAAATTGCTGTTATTTTTAC +TTGATTGATTTTACGGGTTTATAAATATTTTTGATTTGTTATATATTTAT +TTTTTCTGAGTTACATACATACATCAAGAAACATTTCAATATCTTGCAAT +CTAACTGAATTTTATTTTATAATCAGTTATTTTTATTAATCCTGTACTAT +GCCAAAAAATCTAACTTGTTTGAATCAATAACTCAACTACCAATCCTTAA +CACAAAAACCAACACGGTTCTACCCAAACGATGTATAAGCTGGCACCATT +ATAAATTATCCGCATACTTTTTCAAACAAAGGAAAAAGTCGGAAGCTTTC +CATACATTCAACTCTATTATACTTTCCCCTTTCCATGGATGTGCTTTTTG +TGTGAAACCAAAACTTAACCGCCAGAAAGCTTTTTACATAATCTATAACA +GAGGTGGGCGGCAATTGCCGTTCGGCGAACATTCTGATTTTTTGGAAATT +TTCATTTTTGGCAAATTGCCGATCTGCCGTTTGCCGGATATCAATTTGCC +GGAAGTGTTTAGAGGGTTCTTTTTACGACGGAAACACTTAAAACTGTGCC +TTTTTGAAAATATTTAATTTTTATTCTTTTTTTCGGCAAATTTGCCGGTT +TGCCCAATTTGGCAATTCGCCGGAAATTTCAATTTCGGCAGTCTGCCAAT +TTGCCAATTTTCAGAAAAAAAATTTCGACGCCCATCCCTGATGCATACCG +TTTTTGACTCAATTTAAATAGTACACAACCTTCCACATTAATGTAGTAAC +GGTAAGGTTGCCTAATTTGTTTGAACTTTGAAAGCCGCGCACAGCACCTA +CAGTAATCAATCTCCTTAAAGAGTGTTTTCGCAATACCAAACATAGGAGT +TTGTAGAAACATGAAACCGAAGGACAACACATTTTGAAACAGGTGTCACA +TTTATGTATCTGCACTTGATAGCTATGCAGTCAATGAAGCATAACGAGAG +ACATGTGTTCATTCCCGAATGGAGTCAATGAGTCATAAGGTTCTTCGTTC +TCATTTTATTATTACAGGCTTGGGTCCCACATTGATTCATATTATACTTA +CTTTTCAATTCATTGTTTTTTTGTGATTTTTTTTCATTAGAATAGTATTA +TAATAATATTCTTCTAATAATGACAATCGAAATAGTTGCAAGTAGAATAA +CGATTTGTACAGTGATGCCCATAATTGTGCATGTTTATAATGTTCTAATA +TTTCAACGCAATCATGACACAAGCTCTATAGCATCTCGTGAGTTCATTTT +TGGTGAGGTTTCAAAAAAAAAATCCTCTTGCTCAAGAGCCATACGTTTTC +AGTTAAAAATTTCTTTAATAAAATATAATGCTCATTTCTCGAACGTTACC +TGTTAATGTTAACTGCGCCTACCATGTCCGTTCAATCCCACTAGTCAGTT +ATTCTTTGCAATTAAATGATAAACTTTAATGTCTAAATCTCTTCATGGAT +ATCTCCATCTCAACCATCCATCGTTTTTTATCAACCATCATCATTCTCGT +GTTCTCGTTCTCGGGGTCGCCTCCGCTTCTTCATCATCATCACCACGACC +ATTCAAATCGTTCATCTTCCTAATCGACATATTCCCGCATTAAATTTCTC +TGTTGGGTATCAATGACTACCCAAAAACGGTCGCATTTTCTGAAAAAATG +GGAAAATTGATTCCTAATTTATTGGTTTTGACCGGTTGTAACTAACCCCC +ACACACTGTTTTTTGATACTACCTACGTCTATTTTCGGCTAATTTTAAGA +AGTCAATGATTCCTAATTGTCTTTTTTGTTATTTTCTGTGAAGTGAAGTA +TCAAGATAAAATCAGTTTGCGTCTCGCTTCGATTTTCTCATTTTTCGAAT +GCTATTCCCCCGTAGCAATATGGTTTTGTTATTACACATTTGCACTTTTT +TGCTACCCTCCCAATTCTGACTCACACTTGCATTCCGGAGACTGCCTGAG +AGTTAAAACTAAACATAATTGTTATATAATAAATGTCAAAGTTTTTCGCA +AGCTGAAAATTTTTGCCAGCTGAATTATTCCTCCTTCAAAGGAGCATAAG +TCTAAAAATGCTAGAGTTATTGGAAAGTTGCTAATTACAAGTTATAGAGT +TTAAAATTTTGAGTAGTTTCTCGATTTACAATTTTTGAAGCTTTATTCCT +TGCTCAAACTCGAGCAATGAGAGGCAGTGGGGACTCCCCCACTGGGGAGG +GGAGAACCTTGTCAACCCACTAGGGAGGGGAGAACCTTGTCAACTTTAAA +GCCACGTCCCTCTGCAGGGAAAAGATCTATCAAAAGGTTATCAACTAACA +AAATGTGCAAAATTATACGCTCTACATTTTTGTAGTTAACCGTTTTCTGT +TATCACAGTTAGTTTTTGTGAAACCATCAAATCTGTAGTTTCTCCATTAT +TATTATCACCTAACAGTATTATTATCAGCTGATAAGTATCCTTTCTTTTT +GGATAATCCCCTTGTAAAGGAATATACCATTGTCTTCATCTCCTTTTTCT +GTGTCTACCCTTATCTTTGGGTCGCCATCTGCCTCTCCTCCCCGCATATC +CCCTCTTATATCTTCAGAAATTCAGGTTCCAAGGAATATTCCGAAAAATT +TTGTTTGGAAGGTGACATGTCCGATCAATCGCTGGTCCAGAAGGTTCCAC +TACTTGGCTCGTGTTCTCAGGTGAGTATGCGCCTTTAAACATTGAGGGTA +CTGTATGCACCATAACGCAAAATTGCAGATTTTATAGTGGGGCAGGTTTG +TTCTACAGATAACCGTAAAATTTTTATGTCCCTTTAAAAGAAACTCGTCC +GAAAAATTGATAATTTACGAGGAAAACAACTTTTAAAAATGTTTTTTTAC +TTCAAACGATGCTCTATTGTGCCGAATCGCTTGTTGTTTAGCGGCGTTTC +TAAATATTTATTTACTTATCGAAAATCTTTTTTTTCATATTTATAACTGT +TTAAACAAAATCGATAATATTTATTTTTTCTGAAACTATTCTGAAAATTT +TGAATTTCCCGCCAAAAAAATTTCGGAAAATTTTGATTTTTTTTGGCATA +TTATTTTCTGATAGAATTTGAATTTTTGGCCAAAGAAATTCTGAAAGTTT +TGAATTTCCCGCAAAAATTGTATTTCTGAGAGAATTTGAATTTCTTGCAA +TTTTTCTGTGAAAAAACAATTGAAAATAAACGTGGTCGCCAATACGAGAA +AACTCGGCCACCGATTTTTTTTTCGCAAATTTTGCATTCGTTGCTGCATG +ACTGCCAAAAATTGGCGGCCGAGTTTTTTTATTCTACAGGGTTAAATTTC +ACAGATGGCCGAGTTTTCTCAGTTTCACGGTCACAGGCTTCTAGTTTATT +ATATTCATCTCCGCGGCGCGCGCACCGTACTTTCTCCTTCTCTACTCTCT +CGTTGTTCAATCCCTCTCTCGGATCCAACCAACGCCCTCTGCGATTGTGT +CATCATCGATTTGTTATCTCAAATTCCGTTTGGCTTTTCAATAACCGTGC +CTTATTGTCTCAGGAATTTCAAATTTCCGGTCAACAATTCGGATTATTAA +CCATTTCGAAAAAAATCCTTTAAATTATTTTTATTATAATGAAAAACGTG +CGATTTTTTCTCGCTGGTGGGTCCTGGCACGACTGAAACTTTTCAGCTAC +TGTACCCAGCATTGCTTTAGAATTTAAATTTTTGCCGGCAAATTAGAACT +GCAAGATTTTTTTGTTAGTTTTTAATTATAATTGTTTGGGAAAAATTACA +AACTTTAAAAAAACCTACCGTACTCCCAAGTACTGCAGCCAAGAAATAAT +TTGTTTCGTGCCAAGACCCATTTTTCCTTTAAGAACTAGAAACCTCCCTT +GTTTACAACTGTACTTAAAATCGAATTAGTTTGTTCGCTAAACATGTTTT +TCGCGCGAAATTTCGCTTTACTTTCGAAAAATGTTTTTCTTCATTTTCGT +CGGCATGCGCCTTTAAACTACTGTTTTTGAAACTTTCGAATGATAGAAAA +AATTAGAAAATATTTTTAATTTTCGCTTTCGCCGGAATATTCGAAAATTC +GAAAAAAAAACTAAATTTCATGGATTCTCAGTTAAAATTCACGGAAATTA +AAACTTGCGTAGCGAGACCTCAACGATCACATTACCTATGCGCCTTTAAA +GCTACCGTAACCCTATTTTTAATTAAAAAAAAAAGAATTTCCTTTTAAAA +TCGCCGGATTTTCTCCGTCTCTTTTCCCATCTTTTTTCATCTTCGGTACC +AATCATATGTAGGTGAGAATATCTCTGCACCCTCCAACGAACCCAACACT +ATATCGCTGCGCACCGTCCTTCAACGATGTCATCTTCCTCCTACTTCGAC +CCCCTCAATTTATTTCCGATTTCCTCTGATTTATTGATCTTTTTTCCTCT +TTTTCATCATTTCTACGTTCTATAAAGCGAGGTTTATAGCCAAATGGACT +CATTCAAACGATTACAATCCAAAGTTTTCACGTCAGTGAGCTCACTGCGA +AAATCTGAAGAGAATGTGAGTAAAAAGCGGCGGAAGACGTAAAACATCTG +AAATATTTTTAAAAAAATTTGTTAAAAGCCCCACATTTTCGAGATAAATC +TAAATTTTCAAGTTTGTAGCAGCAAATTAAGCAAAGATATATATTTCAGG +CCGACGAGCAGACATACAACACAAAACGATGCTTCATCCACGTCAATCAC +TTATCGATCGCGATCGCCGTCGTCGAGCTCTCGATTTTAATTTATCAGGT +AATTTGTTTGCCTGCAACTCAGACCAACGCTTAGTCGTCTAATTAGATTT +CAACCATATTTGATTAGAAACTGAGCAAATATAATGGGGACATAATTAAT +AGGCTTATGGATTTTATTTGATTTGACAATATGGATTTTCTAACCAAATA +TGGTTAAAATCTAATCCAATATGGAGCAAATCTAATCAAATATGGCTGAG +ATCGTGCCATATTGGATTAGATTTCGACCATATTGGATTAGATTTGTTTT +CTAATGAAATATGGAGAAAATCTAATCTAACATGGATTTCTAATCTAATA +TGGAGCAAATATAATGCAATATGGATTTTCTAAAAAATATGGTTGAAATC +TCGTTGAATATGGTTGAAATCTAATTAGACGACTAAGCGTTTATCTGAGA +AACTGGAAAAACCTAAAAAAAATCTGAAAATTTTCAGTTTTGTGTGGAAA +AAATCAATGAAAAACTCAATCCTACAGTAATTTAAAAATTCTTTTTCACT +AAAAAAATCAGTTCCCATTGAAAAAACAAACTGAAAATCAATTATTTCAG +CTCTCAAATGGCAGTTGGGGCAATTCGGAGCACTCGACCGTCTTCACAAT +CGCCGCCTTGCTCTTTCTGCTCGTCATTTTTCTGCTTTTCGTCGCGATTT +TCTACCAAATCGGAAATCTTCTCATCCCGCACATCGTCATGCAGATTCTG +CTCGTTTTGTGCTTCCTGGGACTCACATGTGCGACGCTTTATGCGCTTTT +CCACGGTGCCACGTTTCAGTTGCTCGTCGTGGTTACAAATCCGCAAATCG +CCGCTGATTCCATGGTAAGTGTGGTAAAAAATGAAATTTGTTTCCTTGGG +AAATTCCTTCTTTTTCCTCAATTTTTCCTCATTTTTTTGCTTCCAAAAAA +AAGACCCATTTTGCGAAAAAAATTTTTTTTTTTCATTAATATATGTATTT +TAAATTTTCCAGACAATTCTCCCGGCGCCAATGATCACAACAAACGTGGT +TTCCGGATTCCTAGTGGGCCTTCTCGTCATTTTCGCAGTCTCCTACTTGC +TCATCGCTGTGCTGAATGTGAGCTTTTCCCATGGCGAGACCCATGTAACT +TTAATTTTTGCAGACCTGGTGCATGTACGTCGTCATCGATAGTTACCAGC +TTTTGAAGAGCCAGAAACTTCAATCTCGTACTCCGTCGGTCGAGGAGTAT +TGTGCGCCGAAGACGATTCAACTCTCACTATACCCCAATCAAATCGTTCA +GGCCACCGATTTTTAGTCTATATTTTAGACCATTTGTTGAATTTTTCTCG +AAAAAATCCGGTAAATTTTTGTGTATATATGTCCCGAAATTCTTCACTTT +TATCACATGTGTCAGGCTTTAATTTTTTCATACTTTATTTTCGAATTCTG +TACAAAAATCTTTGATATATTCTATTTATTCTTCTCAATTAATAATCACA +CGATCCATCTTTCCACCCGTCTCGCCACCTTTGCATCACATCTCGACACT +CGAACTTTGGTTTTCCGGTTTTTTCGTTGACTTTATTGTGTAGCTGGCAC +ATCCATAGCGCAAACGCCTCGCGGCTTTCCACTTTTGGCGGCGATTCTTT +CAGATCTTTTCGGAGATCTTTGGCGCAGAAATCGCAGGGATATGTCTGAA +AAATTTAGGCGTTTTTGTGGGAATCTTGAGCTTATTAGCTAACTTTTCCT +AGAATAGACATGAAACTTCTGGCTCGATCCTTATCCTCGTCGGTAGGCTT +TTCCGGGTAGTAAACCGACATTGTGTGTAGCAAATTCCACGTGGATCTGC +CTGAAATTTGAAATTTTTGGTGGAAATTTGAATTAAAAGCGAACCGAGCT +CATCCTTGTCTACTGGACATCCGTGCAACTTCGCTCCTGTGCTCGTGCTC +GGCGTCGTCTCGGATTCTGCAAAGAACTAAAATAATTGAGATTTTTTGCT +CTGGAAATCTAGGGAAATCACCTTTTTTCTTTATTTTTTCAGCCATTTCT +CTGCCTTTTTTCATCATATCCTCTACACTGACGCATGCACGACACGGCTT +TCCATCTGGACCGATTTCCATTCTGAAATTAATTTTTAAACTTGGTTTTC +GTTTCGTCAGTTTTAGAAGCCGTTTTAGGGCGTAAACTTATGAAACTATA +CATAGTCTACGACAAATCTATAGAAATGCATTAAAAATAGGTCAAAAATG +TGAGAAATTGCGCAAAAAATGATGCAAAAACGAAAAAAAATTAACTAAAA +ACAAGAAATGCAAGTGCGCTCCACTGACACGCGTTAGAGAGCGTAGACGC +AGAGAAATCTCGAGATGAGGGAAATCGTGGCGCGCGGGAATCAAGCTTTT +TTGAATTGTCTTGATTTTTAAAGCCCAAAAAATAGATTTTTGGCGGATTT +TTGGTGGATTTTCTTGCTTTGCAATGTAAAAATTAATTATTTGTTGCATC +TAATCACTTTTAACAGAGATTTACAATTTTTTTAGTGGTCTGAACCTGGG +AAAATCCTTCAAAAATCAATTTTCCCTACAAAAATTCGTTATTTACCGCA +TTTTCCGCCCAGCTGATCAAAAATTCTTCTATTTTCTCAATTTATTGATA +ACACTCGCCCACCTCAAGCATTTTATCACCTGAAACTCGTCACACTTTAC +AATTTGTTTGCAGAAATATGCGAAAATGAGCGTTACTCAGCTAAAAAATC +TGAAACACGCGATAGCTCAGCTTCTGGAGTGGGATGGAACGAAAACGGCG +AGAAAGGCAAGTTTTTGGTGGAATTTATCGAAAAAACCTGATTTGTTTTT +TTGCAGAAAATCGTCGACGAGGTGGTTCTTCTCTATCACGCTCTGGGAGC +GGAGGCATTAAGTGAGGATAACCAGGAGATATATGATTTGTATGATTTAT +CTGCACGTATATTCAACTTAGCTAAGAAAGTTAGTTTTTTTTTTGTTAAA +AAGTCGTAAACAACAAGTAAATTTAAAAATAAGCATTAAAAAATATTGAG +GCTTATGAGAGCAAAAAATTCCAGGAAATCGAAGAAGCCAACCAACAATT +CGAAAAAGAACGAAAAAAGGGCACAAGACGAAGCGAAAAACCAGTCCCAA +CTCCACTTTTCGAGCTATCAATACAACATTTAAAACGTTGCTGTCAGCAG +GGAATCGATCACAATCAGGTGCCATGGATAGCATATTGTCTGAAACTACT +GGAATTTCCAATCACAATCACCGAAAAATCGATCGAAAACGAGATTTCCA +ACGTGCTCCTATTGAGCTCCAACGCCTCACAGCTCCATTGGGCCGAGCAT +GCTCATTTGAGCAGCTTATGGAAATGGATTTGGAGCCGTGTCGAGACCGC +CGATATTGGGGCACTCGCCATGAGAAATTATATGGAATTGGCGGCGAACT +TGCTGGAAAACGTGGATTACGTGGTTTTCGAGAAGTCGCCTATTGACCTG +ATGGCGAAAGTGATGGGAACACTGAAGAAAAGTGTGGAAATGGGAAATCC +CAAAGAATAGTGCGTGGAAAACGAGTTCTTGAAATAATGTTCAAAAAATT +CAAATTGGCTTGGACTTAGGCTTAAGCTTAAGCTTAGATTTAGGCTTAGG +CATAGGCTTACAAGGGAAGTATTTCAACTTATTCCCGGACTTCAGAATGA +AACCTATGTCATTTCGAAGAAGACTCTTTAAGTAGGTCCCTACAAAAAAT +TTAGCGGCAGAGGAGCACTTTGACCTGGAAAAAAGTCGCTCTGAAAACTT +TTCAGTGCATTTTTTCACGGCTTTCAAGGCCCGTAAAATGGCTCCAAATG +CGAATTTTTGTAGATTTTTGAAGATTTCTAGGATGCTCAGGGGCCGGAGA +GCACTCGGAATTTTTTTTGGAATTTTTTAAAATTTTCGAAAAAATCTGAA +ATTTTTTGAATAAGTCCATGGCAAAATTTTTCAGTGAATATATATATATA +TTTTTTTTAAATTTCAGAAAAGTTGTCAGTTATTTAAGATCAAAATTGGG +TGTTTTTACACAATGAAAATTTTTTTGAGATTTTTCGGAACTGCAAAAAC +CAATTTTGGAAAAAAATCGGCACCCGGAGTCGAACCCCAGTCTTAAAAAA +TATTAATCAAACTCGCTAACCACTCGGTCATTCAACGACAATTTTTCTTG +TAAATGAAATGGATGACAAAAAAACGTGACTCTTTGATATCTACTTAAAT +ATATAGGGACGTGAGAAATAGCTTTGGAAAAGGAGAGGACGCAGAGAAAA +ATTTTCAGAGCGACTTTTTTCCAGTTCAAAGTGCTCCTCTGCCGCTAAAT +TTTTTTGTAGGGGCCTACTTAAAGGGTCTTCTTCGAAATGACATAGGTTT +CATTCAGAAATCCGGGATTAAGTTGAAATACTTCCCTTGTTAGGCTCACT +AGGGAATGACCAGAATAAATGGAGCGATATTCAAAAAAAATATATTGTAT +CGGAAAGCTGGCATTCTCTACTATAAGAATATGACTGAAATTTTTGCCCG +TTCGGGCTGGAAATCTGAAATTTTTACGTCTGAAATTCTACACTGAAATC +AGTGCATTTCCTATGGTTAACAGTGGATTTTTGTCTCTGGCGCCAACAGA +AGTCTCACCACAATGGTGGAAGGGCGAAAACATCGGTTCGGTGGTCGAGT +GGTGAACGCGTTCGCCTCTTGAGCAGAAGTTTGTGGGTTCGGTTCCCATA +CATGGTTTAACTTTTGGCCTTTTTTATACAAAATTTTCAGAACGGGAAAC +AAGTATTTAGAACATTTTTTTGAGGGTTTTACATAATTTTTTTGCTTTTT +AATTGAACCATAATTACCCTGGAAACTTTTCAGAAATTTTAATTTTTTTC +GAAAATTGTCACTTTTTTCTCCACCAAACCCATGAGAAAATTTGATCGAA +AAATTTTTTTTTGAAATTTTTTTAAAAATGCATGAAATATTTTAGAGTGT +CACAAATAACCTATTTTTCATTATTTTCAATGACCGAATCATTGATTCTG +ATGCCTTATCAAGACGTTTTACCAAATCGATATTGGCAAAACATCTTGTT +TTTGAGGCTCCATATCTCTGCAGGAAAAAATCGCACTAAAAAGTGATCAA +CTAGAAACTTGTTAAACACAATGTGATCTAAAACATTTCAGTTGAACACT +TTTTTGTAAAAAATTTCGTTGCCGAGTTGGAACCAATTGATTTGAGCTTC +ATTATTTTTGAATATTCTAAATAGTTAAAGATCTATATCTTGGCAACGAA +ATTTTTTACAAAAAAGTGTTCAACTGAAAAGTTTCAGATTACATTGTGTT +TAACAAGTTTTCAGTTAATCACTTTTTAGTGCGATTTTTTCCTGCAGAGA +TATGGAGCCTCAAAAACAAGATGTTTTGCCAATATCGATTTGGTAAAACT +TTATTTTAATTTTTTTTTTTCATATTATTGTTTTTATATTGGGTCAAAAC +GTATTTGCTCTGCTAAATAGTTAGCTGGCGCTAATTTTTAATTTTATTAT +TTTCGTATTTTGATAAATTTCACTGAAATTGTCACTTTAATAGTTTACAT +TCTATTGGTTTTCTTTTATTCAATGTCTTTTGATATCGGAAACGTGATGT +TTGCCTTGCATCGTCATTTTCCCAATCCCCTCCCATCAAATCCCTCGATT +TCGAGACATGAGCAGAAGGTGGCAGATCATTTGGCAAGCATTATAAAGGA +ATCTTATTATGGAGATACCAGTGTGGAAGAATCCGAATATTTGGTTCAAG +AAGAATATGGCGATTGGGAGCCAGAAGTTTTTGAGGTATGTTGGTTTCGA +CACTATTAATTGTCATTTAAAAAACCTTTCAGCCGTATGACTGTGTGTTG +CCGGATCAAGATGATGTATTGTTCGGTGAGAAAGCTGTATCAAGGGAAGA +GTTGGATAAAGCGATCACCTTCTACCGTAGCGGAAAAATTGGAAGTAGGC +CGATAACGACTATGCACCATAGTTATCGCTGGATACGAACCGATGCTCAT +ATGAACAAACTGCGCAAGTACGAGAAAGATAAAAAAGCGTTCCAAGAAAG +CGTGCGGGTTCGTTTGGCACAGCTTACACAACGGCTTTATGAGGAGGTCA +AGGAGAAACTTGATAATGGTAACGAACATTAATATAACAAGTTTTAATAT +AAATATTTCAGGAGTCAATTTGCATGATTCTGATTTGATGGCTATGGCAC +TGGAAATCAACACCCGCGAAATGAAGTTGCAAAAACAAAACGAAATGAAG +TTGCAAAAAGCGTCACAATCCTGGATAACCCGATGGAAGCAAAGCCACAG +GTATGTAATAAATTGCGGAGTATGTTAGATATATATATATATATATATAT +AATTTCAGAATCGTGAGTCGGAGAGTCACCAAGTTTGTCACACGGAAGTG +CCTGATCAATAAAGACGCTATCAAAAAAAACGCGGATGATTTTGTCAAGA +ATGCCAGAACAGAGATCTCCAACTATCACCCGTCGATGGTCTTCAATTGT +GACCAAACCGGAATTCAAAAGGAGCTGTATCCAGCCCGGTCTTTAGCCTT +TATGGGCGAAAAAACAGTCGAGAGGTTGGCGCAATCGAAATCGTCGCTGA +CCCACTCGTTTACGTTTCTCCCGATGATTTTCCTCGATGGCTCAATGGGA +CCCAAGGCGTTTATGGTAATCGCTGAACCAAAAGGCCAGTTTCCTCCGTC +TCGTCCAATTCCAAACTGCCCAAATTTGGAAGTGCGGGCTGGATACAAGA +CACACATCATGACGAAGCAATTGATGTGCGATTTTTTCGAAAGTTGTGTC +TTCATTCCGTCTGTACCGAAAAAACTGTACATCATGCTGGACAGTTGGCC +AGCGTTCAAGGACCATACAACGATCAAGAACTTGGTTCCCAATGGTCATG +ATGTCGTCATTCGCAACATTCCAGAGCACACAACTGGAATGATCCAACCG +TTGGATGTCTATTGGAATGCGCCATGGAAGGTATGAATTTAAATCTTTAT +AACTTTTTGATAGTATTTTCCAGAGCTTGATCAAGAAGTTCACAGCATAT +GCCCTTCGAACCCAGACGGATTACGTCATCGCACAGAGGAACAACGCAAT +TTGCATGGTATCTGTGTTGTATCACCAGATCTCGGCAGAGCACTTCCGAC +CGTTTTTACAGCATTGTTGGAAGAAAGCTGGATACGTGGGTGCTGCGAAT +ACTTCATCAACACCATTTTTGACTCCAGCTCAATATTGCATTGATCATGG +TGACACAGTGATTTGCTATCACACTGGATGTAACCATCTCGGATTCATCC +GATGCGCAAGATGCAAGATGTTTGTTTGTTTTAATCATTTTGTTGTGTCA +AAACAACATCTTTGTTCATCTCCTTGAATAATTAATAAATTCATGATTGC +ATTACATTCAAGTTTCGCTATGAATAAAATTGTTTATATGAGGGGATCCA +TGGTTGTAGTGGTCCATGGTTAAGTTTAAATTTTAGGGGAAAAGATGTTG +AATGAATCATTATGGTGTTGGTCGACACATTGATCATGCTGATATCGATC +AGAAAAATTAAAATTTGGGCTTTTATATAGTTTCGAAAAAACACGTTTAA +ATTTTTGAAAAACTTTACGTTAGGGTGGAATTGAACCCCAGAGTCCCACC +ATGCTTGTCATCCACTCTATCCACTCGGCCATCTCGCTGTTGCAGGCAGT +ACTAATTGGGGATGGTGATAAGTAAAGCACGTCAAAACGAATAATTTCAG +ACGTAAAAATTTCAGATTTCCAGCCCGAACGGGCAAAAATTTCAGTCATA +TTCTTATAGTAGAGAATGTCAGCTTTCCGATACAATATTTTTTTTTTGAA +TATCGCTCCATTTATTCTGGTCATTCCCTAGTCAGGATCAGCCTCAGGCC +TAGGCTAAGCTTAGGATTAAGGGTAGGCTTTGGCTTAGGCTTATGCTCAC +GCTTAGGCTTCGGCTTGAGCTCAATCATACATCTTGCTTAAGCACGCAGC +TTAACAGCAAAGCTTAAGCACACAGATTGGGCTTAGGCTCAGGCTCAGGC +TTAGAAAAAGTCGAAAAGTTAACTAAGTCAAAAAATTTTATTGTTAAAAA +ATTGTTTAAAAAGTATTATGATTTTAATAGAAAATTGGAAAAAAACCGAA +AAAAAATGAACATAAATCAAAAAAAAAATTTTTTTTTAAAGAAAACTTCT +TTTTTTTGAAAAAAATGCAATTTTAAGGTTTTTCTGAAAAAAACTGGAAA +ATACTTTGATTTTACTGTAAAGAGAATTTTTTCTGTTTTTTTCCAAGATT +TCAACTTATTTCTGCGAGTTTTTTTTTTCAAATTTCCTCTTATTACAGTT +GGTGTCATTACCGAAAATTCTCGGTCGTCCACATTCTCTCATATATCGTA +CATCGTTGGGGTCTCGAAGCGAGAGATTTCATTCTTCGTGAGATTTTCGA +GCTCACTGGTAGTTTGTCCAACTTGATATCAGTGGCTCATAAGGATGGAG +AACAGTCCAAGGTTTGAGTTTTTTTTTCTGAGTTTGCAAACGCGCCCTAA +TTATAAAAATTTGGAAAATTCCACGTGGAAAATAGTTTGGCGAAAGTTTT +TATACAAATTTTTCGTGGAAATTAATTTTTTTTCGAAATTCTCTTTTAAA +AAATTTAAAAATGTTTTATTGGCGTATTATTTTTCTAAATTTCAGTTTTT +CGCAGATTTCACCAATAAAATATTTTTTTGAAAAATATCGCTTCGAGACC +CAAAAAAATAATTATGATTTCAATGAAAAATTGAAAAAAGCCAATGAAAT +CGAGAAATTATCGAAAATAATTCGAAAATTGGAACTTTTTAAAAATTTTA +AATTTTTTTCAAAACAAAAATAGTTTCTCAACTTTTTGCTAAACAAGAAA +TATATTTCGTGGCGAGACCCATTTCTACTAATTTTCTTTTTCAGAAATGC +ATAATGCGTTTGATTGATGATCTCGTGAAGCTCGCCATGATCGAAACCGT +ACACGGCCACCGTACCATGAACGAAGTGACACGTGGAAATATTCAAAAAC +TCGTGAAAACCGGAATCCAAGAGTCTCTGAAATCGGCGCACCGAAATTTC +TCAAGGAGTTCGACATTTTCGATTTCCGAAGAATGCGTGAGATATCTGAC +GAGATGGTTGTTGGCCGAACGAAGACTTGAACAGCCGTCTGCGGCTATGA +ATGAATCGTTTGAATTGACCGGTGATAGCAGTAGTAAGAAGAAGGACGAT +GCCACGTTTGATAGTGCGTAAATGGAATTCTACCAAAAGGAGATCTACAA +AAAGAAAATCTACGAAAATAGGATTTGGCACGGTGCCAGATCGATCTTTT +TTCGGCTCAAAATTGGAAAAACCTGCAATTTTTATACATTTTTGGCTTCG +AAAATCAGGGAACTCTGCAATTTTTGGCATTTTTCGCTAAAAAATTGGAA +AAATCTGCAATTTTTATACATTTTTGGCTCACAAACTGGAAAAACTTCCA +ATTTTCATCTCAAAAAATCGGGAATATCCGCAATTTTCCTCACATTTTTA +GCTTAAATAATTGAAAAAATCTGCAATATTTTACATTTTTGGCTCAAAAA +ATCGGGGAATTTTGCAATTTTTTACATTTTAAGTTTAAAAGTGGAAAATT +GCAAAAATCGGCATAATTTTGAACGTTTTCTTTTTTCCGGTTTTCCGTTT +TGTTACGATTTTCGTTTTGCATGGAAAATGCTTCGATTGATACCCTTCTT +TCGGAAACGAGTTTCTCCTGAAATAGGCGTAGTCTCAAACCATTTTATGG +GCGTGGTCTTTCTCTTATCTTGTTTTTATAAATGTTGTTCATTAAAACAT +TTTCAGGCCTTATCGATCTCTCCTTTGGCTCGACGATTTCCGGAAAACAT +AAATTGAACGCGTGGAATGGTGTAATGCAAATCCTGAATGAGCTCCTAAA +AAGTCGACGACTCGAACTTCAAGTCACTGAAAAAATCGTGACAATCCTCT +GGGAAAAGCGAAAATCCTACACAACGGAGCCACTCCGTACTGTGTTCTGC +TCCATTCTCTCCACAGTCGTCTGCCAGGCCGATGTTCGATTCGGTCATCG +GAAAGTGCCGACAATCGACTCGATTCTCAAATATTCGCTGTCTCTAATGC +CAAATGTCGCATCTCTTCCCAGTGCCGCTGCGTTGACCGAAACGATTGTC +AGATTCAGGACAGTATCACGAGAGGGTCTCCGTAACACGTGGGATACCGT +ATCCCGAACTAGCTCCGGCTCATTTGAAGTTGTTCGGCTGATTTCGGCGT +TGATCTCCGTTACGGAATTTGATGAGAATTCGAGATTCGCCAACGATGAG +AGAGTTCGGAGTTGGAGGTAAGTCACTATGCCACGTGGATGGATTTCCTT +TAAAAAGAGTTTTTGGAAAACAAATCAGATTTTGTATATCACTTCACCTT +TAAAGCGAAATTCTTGTTTTTTTGCAGTTTTCGAAAAGACATAATCGAAT +GGGTATTGCTGGATCCGAATGCACATAGTCACAAATTACTCTATCAGTTG +TGCCAGTATCATCCAACGTATTGTTATGAATCAGAAGCTTCTTCTAGTGG +TTAGTTTATTCCGTAGGGCTTCCATGGTAGGCAGGCGCGATTTCAGGGCC +TGACGCCTGCCTGAAACCTGCTGACCTTTCGCCTCTTTTCTCTCATTGCT +ATCAATTTGTTGAAAATCAAATTAAGAAATTAAAAAAAAAGTTCACGTAT +GTTTTGTCGTGGATTGAGGCGAGGGGCAGGTGGTGGTGGTCTTAAGGTCA +GGTAGGCAGGTGTTTTCACGCCTACATTGAAGCCATAGTACCCCATATGC +CGAAAACGCTGAAGTTTTCTCATTTTTCCAGACGACTCCCTGCTTCAAAC +TCTGAAACTATGTAAATTAGCTTGCTCTCCAGCTCCCCCATCGGCTCCAA +AAGCCCTCCGACCACTCGAAGCTTCAATTGAAGAGATTGTGAGATATGTG +CATGATAAGCTCAAGAGCATTCTCGGTGAGCATCGGCTGTCGTTTTTTTG +ATTTTTGAATTTTTAAAAACATTTTCAGCGACTGAAATCACTCTGCCTGC +ATTTGTGCTCTGCCACGAATTTGCTCTGAAGTATCCGGATAGATCTTATG +AGTTTAATGTTGGTTTTTTTTTCTAATTTTCGAAAAATTTAAGAAATTTT +AGGATATAAATAGAAATTGAAGAGAATTTGAATTTTTAAAAAATTTCGAA +TTTATGGAAATTCAGTAAAGTTTGTCGGAGTTTTTAAACGAATTTTCAGA +ATTTGTAATAAAAACTAAATTTTCTAATTTTTTTTCCACAATTTACAACA +TCTAAAAAACTTTTTAGAAATGAATTGTTAGAAGTTAGAATTCCTGGAAA +TTAAAAAAAAATTTGGATTTTTTTAGAATTCTTAAAAGTTTGATATTTTC +AAATGATATGAAGTTAACACATTTTTTAAAATATTCAAAATAAGAACATT +TTAATTTTTTTGAAGAAATGTTCAAAAAATTAACATTTTTTGGGACTTTC +AGAAGTTTCTTCTTTTTTTTTGCGTCTTTCAAGATTTTTTGCAATTTGCG +TAATTTTTATTAAGGGGACAGAAAATTCTGAGAATGCGGATTGCACAACA +TATTTGACGCGCAAAATATCTCGGAGCGAAAACTACAGTAATTCTTTAAA +TGACTACTGCTAAAATTGAGCATAAAAATAAAAATATATCGATGTATCTT +GGATCCCGTAAATCGACACTAGCGCGCTACAGTAGTCTTTTGAAGAATTA +CTGTAGTTTTCGCTACGAGATATTTTGCTCGTAAAGTGTGCACGAATTCT +TATAATATTTTGTTCTCACAAAAGTTGGTCAATTTATGGGATTCTCAAAT +TTTCGATGTTTTTTTTTTTGAAATTTAAGATTTTTAAAACATTTTTCAAA +AAACTGATTTTTCTCTTAAATTGAAAAGGTTTTTTTTTCAGAAAATGTAC +AAAAAGCTCTACCAAATCATGGAAGATCAAGAAGAAGACGAGTTTCTCCA +ATCAGCTCGCCATTTCTCAAAATGGCCTCAAAATCTGACACTACCAATAC +AAAAACAGACAATAAATTGCATGGCTGTCTTTTTCGAAGCGAATCTTGAC +AATCAGCTCGTCGATCTCTGTCAGTGGAGTGACCGACGAAAAGTGCTTGT +CGAGATGCTCGCCGAGCTGGCCGCCACAAGATCTGAAATTCGAGATAAAC +TTCAAAAATCGATGCCGTTCAACAAATTCGTCAAGGAGTGTATAATGGAG +AATCGCGGTGATTTGTATGAAATGACAAAGAGATTTGAGAAATATTCGTT +TTTGCTCTCGATTCGGAATTTAATTGTTACTAGGATGATTATAACGTGAG +TGTTTGTTTTGGGGATTGCCACGAAAAACTGGAAAAACGTTTCGAAAATT +CAAAAAATATTTCTTCAACATTAGAAAGAATTTCCATTTTTTATATAATT +TTGGAAAGTTTTTAGATTATTTTAGATAAAAAATCATTTCGAATTTACAA +AAAAAAATTATGAAATTTTAAAAACAAGTTTGAAAATGTATTTTTAAAAA +ATTTAAATATTAATAAAAAATCTTGTTTGAATTATTTAAATGTTTGCTAT +TGTGTTTTAAAAAAGCTTAAATTAAAAATTTTTTTCAACAAATGACTAAA +TTAACAATATATAACAAAAATTCAAAAAAAATTGTTTTCGAGAAAATTTT +TTGCTTTTTTTAAAAATAAAATTATAAAAAGAAACAGAATAAAAATCGAA +AAAAAAACAATTATTTTGAAATTTTCAAAAAAACTAGAAAAATGTAAAAA +TTTTGAGGAAAAAAATTCAAACATCCCAATTTTTGCAGAAACGAAGCCGC +CCGACTCCTAGGAGATGGTGAAACAATCAGTGAAACCGATATCTTCATAA +TCGAAAAGCGTACTCTTTCCACGTGTATTCGTAATGTGTCCGAAGGAAAA +GAGTTGAGCGGCTACACACTGGACCCCTATACGGTAGCTGCCAACGTGCA +CAATGTGCATTTCGATCACATAAACGTCGAAATCTATCTGGAATTGCTGA +AAAAGTCGCCATTTTTCGCTCAGAACATTGTACGCCACTTGTTACGGCAG +AATGGAAAAGAAGCAGAAGAAGAGACGTGGCACTTGCATGCCACTGTGCT +GAAAATTGTGATGAAAGATGAAAAGTTGCTGGCGGTAAGGAATTTTTTTG +GAAAAACTTGAAAAAAAAGAATTTCATCGTATTTTTAAATAATTTTTTGA +ATGAAAAATTCGGTACTTTTCCTTTTCTACCCCGCATTAAAAAAATATTC +AAACTATTGACTTATTCGAATTTAATTCTCACGTGAATGTTTGTATTAAT +ACTATTTTCATTTTTAGGCTTAGAAAACAACAGTACTAAGCCTTGAAATA +CAGAAAAAGAAAAAGAGTTCACGTTTTTATCAATGAAAATATTCCTGAAA +AAATGCGGGGTAAAAAAGGAAAAGTACCAAAAATCAAACTTTCAAAGTTA +ACAATACGCAAGTTTTCAAGTTAATTTTAATAATGGATTGTTTAAATCCG +GAATTAAAAAAGTGGTTCAAATTTTATTTTATTTGACTCTATTGTGGCGA +TTTTCATGACAATTGAAACGATTTTTGAAACTTGTATTTATTGAAAAAAA +AGTTGAAGCAGGTCGTAATTTTAATTTGAATATTTAAAAAAAACTTATAT +GGGTGCTTCAATTTTGCAAAACATTGCAATTAAAAAAAAAATTTTCAAAA +TGTGGTCGGCAAATCAGAGTGTTTGAAAAAAATCCTTCTAATTGTGTTTC +CGGAATTTTTGGGATTTTTTCTTCGAAAATAGGAATGGTTTAAATTGAGT +TAGAAATTTTTGCAAATAAAAATCGGTTTTTTAAAATCAATTTCTTGCAA +TCAAAAAATTGAAATTTTCAGCAAAATAATAAAGTTTTCTCTAATTTTTC +AATTTTCAGGTATGCGTGGCCACAATTCCAAATATGGTTCGATATCTCAA +AGTCTATCAGATTCATTTCAGTCCGAAATCCAACGCGGCGAAGTTCTTGT +AGGTTTTGTAACTGCGAATTTCAAAATTTTGCTCGTCTAATTTGACGCCT +GCTCTGTTTTTTTTTACGCGCAAATCTTAGAAATCGGTGACTTTTTCGTT +TAAAAACACCATTTTTCAGTAAAATCTGAGCAATTTTCGGTTTTTGCGCG +TCAAATATGACTAATTGAGTCAAACTTGACGCGCAAAATTTTCAAAAAAA +AAATTCAATATTTTTCCAGACACCTCGACATGGAATCGATTTCCCACTGC +CAATCATATTTGCGAAAACCAACAAAATCATCCAATCTGATCACGGCCGC +CAACTTTTTGACACTTTTCGGATGTGAAAAGCGCACGTGGAAGCGCCCGA +TTCTCAGATTTTGGAGCATTTTCAAGCAGCAACCGGCTATGTGTTGCGAG +AAATTGCTCATTTTTGTAAGCAATGATTTTTTGATAAGAAATTTCCCAAA +AATTTTGAATTTTTGAATTATTTTTGTTAACTTCTTATTTTTAACTCAGT +ATTTTTGCAAACTGAAAATTTCCAATTTTTGGGCTTAAAAAATCTCCATT +TTTCAGGCTGAAGAATGTGTCGAACTTGGCCTGAACCACCGAATCGCTTG +TCTTTTACGCGCACTGACAACCAGTGAATTCTGCCGAAAAGCTCTATGTG +ATGAATATCTGAAAATCGCGTTTCAGCTGACTTATCGATCGATTTTTCTG +ATTTTAAGCAAAAATGAGTGCAGGTTGGTGGAGAAGGATATGTGGAAAAA +CAATATTTGAAAAATAAAAAAAAAACTAATTGATTTGAATTTTCAAAAAT +TCCAAAAAAATAAAGAATTGTATTCCAATTTTCATGAAAATGGCAACAAA +AAACTCAAAGTTTCATTGGAAAATTTTTGAAATTACAAAAAAATTAATTT +TTGAGTTTCAATAAAGTTTCAAAAGTTTAGTTTGAGTAGTGTTGTCAACA +AAAATTGAATGCCTATTAGAAATAGTTGAAAAAATTGGAATTTACAAAAA +AAAACAATTTTTAAACTAATTTCTCGAATTTCAAAAAAAAAATCTTCTAA +TTTTTGAAATTGAACAATTTGGAAATTTTTTGAATTTTCAAGAAAAATTT +TCAATTTTTCGAATATTCAACAGTTCCAAAAAAAAATTTGTTGGATTTTT +TTCCAATTTTAAACAAAAAATTTTCAAATTTCCACAGATTTTTTTTTAAT +TTTTTAAATTTCAGAAAAAAATTAATTTTCATAAAAAATTGAAAATTTCC +ATTCTTCAAAAATAAGTTTTCACATTTTTCAGACCAGAAATTGTGGAGCT +CTGCGATGACATGAATCTTCGGTACGATCTTCTCCAGCACCAGATCAAAC +ATGTCGCGGCTCACCATTTGGAGCACTTTGAGCGTTTCGAAACGAAAATC +GCATTTTCTGTTGAGAAATTTCTGAAATCTGGAATTGATGGAATCGATTT +TGAAGATTTAGGATTAGTCGAGTTTTATAAGCAGTTGAACGAAAATTTGA +CAGAAGACGCGATCAGGAGCAATGAGGCGAGAAGTAAGGCCGTGGAATAT +AAATTGGTGGCCGAGTTTTTTGTAAACTATGCCACCAAACTTGGTTTCTC +CGTTCGTGGCCACAAAAATTTTGAATTTTTTGAGCTTCTCTTATAATGTT +TAAAAGTGATTTCCTGGCAAAAATTCATTTCTTTAATTAGAAAATTCCAA +AAAATTTGAAAAAAAAATGTAAACTCAATAAAAAGTCTAATTGTTTCAGA +TTTATTCTGGTTTTTATTGAATTTTCAGATTTTTTCTTCAATTTTCAGTT +TTTTTCGACTTTTCTAATTAAAAAAAACCAATTTTTGCCAGAACAAAAAC +CATTAAAAATCGACAGTAGTCATCCCATTGGAGTACAAAAATTTTAATGT +CCAAATTTTCATGACGAACGAAGAAACCTAGTTTGGTGGCCTAGTTTCCG +AAAAAACTCTGTCACCAATTTCTTTCAAAATTCAACAAAATTTTAGTAAA +TTCCAAAAAAACGAACATATTCGGCGAAAATTATTTCAAAAGCTTCCGAA +CAAAATCTAAAAACGTTCAGAAAGTTCTGGGTAATTTTTTAAATATTAAA +AAAATTCAACAAAAAAAGGGGGGCAGATAGCTCAGTCGGTAGTGGTGGCC +GCTAGCAGTCTGGAGGTCACGAGTTCAAGTCCGGCCTCACCCCCTAGGTT +CACCCAGCCTCTATTGGGAAGTGGAGCAATCCACGACTGGATTATCGGCC +ACAGTCCCCGGCTAGGACGTGGCTTAAATTACAGCCCAGAGGGATCACCA +CCAGGCAGTGTACCTGAATCCCAGATCCGCAGTGCATAGCACTTGAAGAA +CGGATCGTCCTTTAATTCTTTCAAAACTAATTTTTTACTAAAAAAAATTT +CCAGACATCTACATCGTCGACATTCTCTCAACAATTTGGCTCCAGCTCCC +CTCAATTCGTCCTCAAATTCTACCGATTCTCGCCCGCTTCAAGCACATTT +CCCCAGCGTGGACTAATTTCCCACAGCCGCCTCATATTTCGACAAACGAG +AAATCATTTCTTCAACATCTACGATTTCATCTTTATCTAAAAATGATGAA +TATCTCGAAATCCATGACGCAAGGCGAGTATGCCACGTGTATTATGATGC +TCCTGACGAGCTACGACTCGAGCCATTTCGTTGCGGATTTGATAGAGAAA +AAGCAGCTGGGAAAGCTGAAATTGCAGCAGAGAAGGAATGTTTTGTGCAT +TTTGAGCCGACTTTTGAAAGATCAAGCTGTGATGGGTGATGAAGATGAGA +CGATTATCGATCCGATTCTTTTTAAGGCAATCACCAAAGCTTCCGCCGTT +TTTGTACGTTTTTATACGACGGAAATCACTGAATTTCATGTTTCTATGCC +GAAAAATTATGAGCAATTAAATATACATCACAAGAAAGAAAATAGTTGCC +GGTTTTTGAATTTTTCTGTCATATCGGCAATTTTGGCAACTGCCACTTTT +TGAAGTTTTTAAAAATTTGGTAAATTTGGCAATTGCCAAAATTATCTCTG +TTTCGATTTTTTTCATCAGAATCATAATATTTTAAATTTCGCGCTAATTT +TTTTAGCAAATGATCTTCGAAAATTTAATGTCTCGCAGTTAAAAATACAT +CTTTGCAGGAAGACACCGCCGCGTGCATCGTACCATTTTTGTTCAAAATT +TGTGTGGATTTCAAGGGAAAATACGATAAATGTGTGATAAATTTGCTGGG +ATGTCTTAAGGGAGTTAATGCAGGTATGATTTTTCGTCAGAAATGACTGG +AACGAGTTTTTCGCATCAATTCAAATTTAATGTAATGGCATTTGGCATAT +GACATCGAATGTCGAATGCTGGGAATGCCGAATAATATATTTTGGTCGAG +TAGGAGAATAAACTAGACAAAGTTCAAATATATTCCCAACAGGGATGGCT +TCACCCGTGACCCGTTTCACCCGTTCACCCATTTTTACAAGGGAAGGTTC +TGAACTCGTTATCGGACTTCGTTACGCCACTATATACATTCGATAGAGAA +TGGTTACAGATGATCACTCCAAAAAATTTAGCTGCTTCAGAGCAGGTTCG +ACCAAGTTACGACACTTTGAAGATGCCGAAAAAAAAAATCATTGATGCAC +CCCCTTTGAAAAAAATTGAAAATTTTCACTGAAAATTTTTTTTTTCTGAA +AGTTGATAAAAATAGTTGTAATCGATTTAAATAGTAAAAAACATATATTA +TACAAGTTTTAGCCCATCACTCTCAAAAAAACCCTTAAATTAATGTACAT +ATCTTGAGAAAAATTCCAAAAAGTAGATGTTCATGTAGATCAATTTAAGG +GAGAATTATGAACTGAAACTTGTATGGTATGATTTTTCCATCATTTGCAA +CTATTTGAAAACATTTTATATCAACTTTTAGAAAAAAAATTTTTTTTTGA +ATTTTTTGGAATTTTTAAAAAGGGGTATTTTGGCACTTTCAAAATGTCGT +AACTTGGTCGAACCTGCTCTGAAGCAGCTAAATTTTTTGGAGTGATCATC +TGTAACTAATCTCTAACGAATGTATATAGTGGCGTAACGAAGTCCGATAA +CGAGTTCAGGGCCTTCCCTTGTTAGGCGTTTTTACGGGTGACGGGTGACC +CGCTCGCCCGTTTTTTTTTTCGTTTTAGTTGTTTTCACGGGTGACGGGTG +GCTCGCTCACCTGTTTTTCACCCGTTTTTGGAAGTTTTCACGGGTTATGG +GTGATCCTTGGTTCCCAAGAGGCAGCCAGTTTAGGTCAATAGGTCGTAAA +TATCGTTTTGGGCCACGTTTACAACTGGGCTGTGTGCAACTAGAGGTGCA +CTTGGGTCGAAAAGGGTCGACCCGCTCCAACTTTAGGTAGCATTTGTAGC +GACCCCGATAAATAAAATGTCGACCCCGAATGAAAATTTTAGCAAGGAGG +CCATGCTCGTTTAATTTCCATTTTCAAAATTATGATCGGACTATTGGTTG +AGCTACTGTGAAATAAGCGGGTCGACCCTGCTCGACCCATGAGCACCCCT +AGTGGCAACCATGATTTTCGGCAACTGGCAATTGCCAGAGTTGCCGAACC +CAATAAGTTTCGGCAACCGGCAATTGCCGAAGTTGCCGAACTCTAAAAAG +TGCAACCGGCAACTTTTGCGCAGCCCTGGTTTACAACTACCTAACGACTT +TTGGTAGACTAGAAATAACACATGTATTCGAATTCGACATATGCCGAATG +CCGAAAAAAGTATTGAACGACATTAGGCACAGGGATGGGCGGATACCTTT +TCGGATAACTTCACTAAATCAATTTATCAATAAGTATTGATTTAGTTATT +CTGGAGATACTATACTAGAATAAAGAGTACCTATTGAGCAACATTTTCAT +ATGACAAAAACTTTTAAAATTGTACGCATTTTCCTCGACAAGACCCTGAA +ACTCGTTATCCGATCAAAATCGGCTAACAGATAACGGACTTGCATACTTT +TTATACGGGAAACGTGTAGAATTTTAAAAAGTTTTGTGCCATGAAAATGT +TGCTCACCAGTTTCAATTTTGTTCTGATGCACTTTTTCCAGAATTACTAC +ATCAGCACGTATTGATAACTTGATTTAATGAAGTTACCCGAAAAAGTATC +CACACCCCATAATCAGCATATTTCATATGTCAAATATCAAATTTCCTGAA +TTCCGCACACCTCTGCTCTCCATACTCCAACTAATTTTAATTGCAGAAGA +CGAAATAGTAGTCCGCTGCCTTGCCGAATGCGTCGACTCCATTGGACTCA +ACGTGATTGCTCGTTACGAACGCCTGAACATTGAGACTCATTCGGAATTC +GGTGTGAAATGGTTCTTCAAATTATCCCGTCTCTTTCTGAAACATGGATT +TACTACGCATTCCTTCGCGATTGCGAATATATTATTTGACCGACTTTCGG +CGAGAAAACGAAATACAATGATGATAGATCGTACGAGTTTAGACCGAATT +GACAGATCACAGGAACTTATCAATCTTTTGGTGGAGATCTATGTGGCCGA +GGGTAACTCGGTAGCGTTGTCCTCTCTGCCACCTGCGGTACAAAATAGAC +CGGATGTTCGGCAGGTTATGAATAAGAGTTCAAAGGAATGGTTGAAATTG +CTGTCTTCGAATCAAATGGACTCGTGGGAGTTGACTATTGTGCAGTGGAT +GTGGTAATTGTTTATTTTGAAATTTTTCATTAGAATAGAAAGCAGTTTTC +TGGAAATTTTCAGGAAAACGCATTAATTTTTTACCTATTCTGCATTTCTA +GGTTCTTCAATTTTTTGAGAAAATATATATTCCTTCGAAAAAATCACTAA +CTTCTTTTCGGAAATTTAAAAAAGTTACAGTCGACGACTTTAAAAAATTC +AGTTAATAAAATTAGATTTCAAAAACAAATCGAATTTTTTAATTTGTACC +GAAATCTGGAAAATATTTTTAAATGACTCCAAATTTTTCCCTGATTCCAA +ATATCTATGAGATAAAATTCAAAAAATAATCCCTTTTTGATCTTGAAATC +GCCGAATTTCATTTGTGCACTCATGAGATTTCGAAGTTTCGCGCCAGAGA +CCCCATGTGTTGATTTACGAGATTTGTGTATATTTACGAACCCCTTAACC +TTTATCGGTTGCTGATTTCCGTTTTTCAACGAGTTTTCTTCAGTTTCGTC +GGTTTTTGTTAAAGTTTTTGTTTAAAACATTTTCAAAAAAACTTTGACAA +AAATGAAGGGAACTCGTTGAAAAACGGCAATCAGCATCCGATAAAGGTTA +AGGGGTTCGTAAATATACACAAATCTCGTAAATCGACACATGGAGTCTCT +GGCGCCAAAATTCGAAATCTCATGAGTGCACAAATGAAATTCGCGATTTT +AAGCTGAAATAAAGAACCAGGGAAAAACATTTTTTCACATAGATGTTCGG +AATCAGGGTCAAATTTAGAGTGAAAAACTTTTAAATTTTTAAATTTTTTC +AGTGGCATCCAATTCAATGCAATCACCGGCGATAAATACCTGAATTCAAT +TCTTCGTTGCAATTTCAACGAGTACACCAAAAAAATCGATTCCCCATTAA +AATTCGTCTATTTTCAACTATTCCATCTTTCGACGAGCACTCTGGAAATC +GAAGAAGCCATTTCTAGCATGCCGTTGGCTCCAACAATCGATCAAATGCG +GCTTATGATTATAGCCAACGCGACGGCAAGCTTCGAGCCACAATCCGTTG +AAGAGCACGTTGTTCGAGCTGTTCGAGAGCTCCGAGAGACGTCAAATCGG +CGAAAATCCGGTGGAAATGTGAAGGGAATTAATGAAAAAACAACGAGAAT +GGTGAAACTGGCCGAGATGCTCACCGAGAATAAAGCATACGATGTACGGA +GCAAAAAATAATGGAAAATTTGAATTTATTCAATTGTCAAAAAAAAGGAA +ATTTCCTTAATTTTTCGGTTTTTTTTTTCGGAAAAATCTGAATTTTTTCT +ATTTTGAGCAAAAAATTTAATTGAAAATCCGGAGAAAATCGTATACTTTT +TCTGCGAACCATTTTGTGGGCGGAGCCTAACTAGTAACACTTTTCAATTT +CCAAACAGAAAAGTGAGAAAAAATTCCTCTTTTTCTCAAAAATCTAAAAG +AAAAAAAAATCGGAAATTTTTGAATTTTTCGGTTTTTTCTGAATTTTTCA +ATTTTCATTCAAAGAAGGTCGAAAACTTTTCGATTTTCCGGTTTCCTTTT +TGAAAAAAAATATTTTAAAAATGTGTAGTTTGTAGTTTGTAGTTTTTGTA +GTTAATGTCTTCCACATTTTTAGGCGGCAATAAACCTGCTCGACACGTGG +GAGCACGAGTGTCTCCAATGGACATCTGTCGCTGCCGAATCAATCGATAT +CGATTTAATTCGAATCTGCAAACAACACGTGACGTGTCGGTCGGGAGATC +CAAGAATGGCGGACATAAATCTACGAACAATGCATCCACGTGTCCCGGTG +ATGAGTGACCTGGCGATTGCCGAATGGTCACTCGCGTTGAGCAAGATTAC +AATTGAATATCGGAATGATATGGAAGAGGGTATTCGGATTTTGGAATTTG +GATGCAAACATTTACAGAATAAGGATTCTGTAGAGACGAGGTTAAAGGTA +CATGCGGTCGGGTCTTGCAGCGAAATAATGCATTTTTAAAAATTCGAGAA +AAAAATTGTGAATTTTGCGCGTAAAACGTGATTCAATCTCGAATTGTTCT +ATAGATTTTTCCGACAATTCGGAAAAATGCCGGAATTGAAAATTTCCGGC +AAATCAGCAATTTGCCGTAATTCAAAATTTCCGGTAAATCGGCACATAGC +CAAAAATTAAAAATTTCGGCAAGTCGGCAAATTGCCGGAATTCAAAATTT +CCGGCAAATCGCCAAATTGTCGAAATTCAAAATTTCCCGAAAATCGGCTA +ATTGCCGGAAGTGAAAGTTTTATTGATAGAGATAAATTTAGAACTATCAC +TAGAATTTAAATGTAAAACAACTAGGAGTTATCATGTAAAACTTGTCATT +TGAATTTAACACTAGGAGTCCAATAGATTTTCAGATTTTAAAAAATTAAT +ATAAATTCAGGAAATTTTTTTTGAATTTATCCACATTAATATTCGGTATC +AGGAGCATAAATAGGATCTATTGAGATATTTTAACAAATTTCCGAACAAA +GTTTCAAATATTTTTTTCCAATTGATAGAATGTTCCATGAAACATTACAA +AAAAATTATTCATCAGGTTCTCCTAAAACTCCATTCCGTCTGTATTGGCC +AACTGTCGAAACTCGAAGAATATCGCGAAACGCGTACCTACCGTATGAAG +CAGCAGGCGGTCACCGCATTCGAACAACAAATTCAAAATTCGTGTCGAAC +CAGTCTGGCACGTGGCAATTCGGGTGACGAATGGACGAAAAAAACGGTGC +AACGGGTGAGAAAAGAGCATCAGTTTGAGAAGAATGATTTGGAAAAAGTG +GATAATTCGTTGAATTCGGCGGCCCGGAAAGCTGTATCGTCGGGTTTTGA +TGCACTTTGTGAGCAATTTTTGAAGTTTTTATTGAAAATTCAAAACTTGC +ACAAAAGGATTTTAAATTCGATTTTTCGCGATGTTTTAGCAATAAAATTT +TGAAAAATGACAAATTTTTGAAATAATTTCAGAAAGAGTGTAAAGTTTCA +GAAAAAAAAATTAAAATTAAAATTTATTTTAAAACTTAAAAAAACCGACT +TTTAGCGAATTTTTTTACGAAAAACAAAGTATTTAATTTCATAAATTAAT +TCAAAAAAAATATCTAAAATTTTTGTGAAAAACTGTTTTATACAGTTTCA +GAAAAATTTAAGAAAAAATTTTTTTTCAGAAAAAACCGGATTTTCTGTTA +ATTTGAAATTATGGAAAAAAAAACCCCAAAGGGTATTACGGAACTACAAA +ATTCTGAGAATGCGTACCGCGCAAAATTTCTCGTGGCGAAAACTACAGTA +ATTCTTTAAATGACTACTGTAGTGTTGGTGTCGATTTACGGGCTCGATTT +TAAAATTGAGCAAAAAATTATCACATAATACGAAGAAACGAAGGAAAATG +AAACTAAGTTATAAAAAAATTCGAAAATCGAGATCCCGTAAATCGACACG +AGCGCTACAGTAGTCAAAAATTAAATTAAAATTAAAGGATTACTGTAGTT +TTCGCTACGAAATATTTTGCGCGTCAAATGTGTTGCGCAATACGCAGAGA +TCTCAAAATTCTATGCTCCCGTAATAGATTTAGAAAAATTTTCCGAAAAT +TTACGTCTCGAAAAAGAAAAAAAAACTGGTGTAAAAAATTACACCAGTTT +TAATATTTACTGAAAAAAATTGGTAAAATCTAAAAATTAATCAGCTGAAA +TTGATATGTTTTGGGATAAAAAATTTTGGCGGGAAACTCAAGTTAAAAAA +AAAAATTTCAGTATGCATCAGCCAACTGGAAGACGACGACGAAGCGATCC +GCGCTTCATCTCTCATAATATTTCCATTAATCGATGTGATCTACAAATAC +GAAACGGACGTCGGAGTGATCGCCTTGCTCAAAGAGCACACCAAATCGAA +GCTCCCGTCGAAGCTGTGGATAAGTGCCACCTCACACATTGCCTCTAAGT +GCTTCTCCATCGAAAAATCGCAAATCACGAGACACTTATCACAGATTCTG +TGTCATCTCATCTATGACTACCCGTATCACGTTTTGCACACAATTTTGAT +GTATGATGACGAGAAGAACGCTTCCAAGGTGAAAGGCTTCTTGAAAACGA +TATTTGACGCGCGAGCTGACCAACGGGATTCGTCGAAGCTTAAGGAGATT +GTGATTACTATTCGTGAGGCTCACCAGGCTTATAGGTACATACGGCGGCT +AAATTTTTTTTGAAATTTCGAAAAAGACGAGAAATTCGATTTCTTATCAA +GTTTACAAAAATCTTCGCTTTTTTCTGACAATTTTAGTGTCGTGGTATCC +AATCAACGAAAAAAATTAGGTTCTTCTGGTTATTTTTGAGCATATTCAAT +AATTTAAGCAAATACTCTTTTACTTCTAAACTTTCATCGGCGATACGTGA +ACAATTTCCAAAATTATATATTATCTAACGCTACAGCATATAATTTTTAC +CAATTTTCATTCATTTTGATGGAAAAAAGCATCTAGAACATGTAATATGT +TCAATTGTTCGATTTCAATAAAAACCGACGGCATCCTTGGTTTGAATCGA +AAGTTTAGAACAGTTTTTTTCAGAGAAATTGCAATGCTTGACGTGAGAGG +AAACGTTCGGATACAACGTGTTGAAATAAACGGAAAAACGATGTACCGAT +GGCCACATGATTTGAAGATTTTCAAGTGCAAATTGCGTCAATTGCCGATT +CCCACCATTTCGCAAAAGGTTTGTTTTTATTTTATTAAAATAATTTAATG +AATATGTATTTGATCATACAAAAAAAAAATGTTTTCTTCTAAATTCCAGA +TTGGTTGCCCGGGTGACTACTCGACGACTGACCTAATCACGTGGAAACGA +TGGAAAGATGTATTCACAATTGCCGACGGAATTTCCACTCCAAAAATCTG +GGAAATTGAGGGTAGCGATGGAAAATGGTATAAAACTGTGTGGAAGAAGG +ACGACGTACGACAGGATGTGCTTGTTGAGCAAATGTTTGATGTTACGAAT +AATATGTTGGAGAAGGCGATGCTTCGGACGTATAATGTTGTCCCGTTAGA +CACTGAATGTGGAGTTATAGAGTTTTGTGGTGGAACTGTTAGCTTAAGTT +CGTTTTTTTTTCGTTTTTGAAAAAAACCAAAATAGTATTACGATAACACA +ATATGCTGAGAATGCGTATTGTACAACATATTTGACGAGCAAAATATCTC +ATAGCGAAAACTACAGTAATTTTTTAAATTACTACCGTAGCGCTTGTGTC +GATTTACGGGCTCGATTGTCGAATATTACGGGGCCATGAGATCATGAGTA +TGCCTATTTACTGGCGCGAAAATATTGGCAGGCCGCGGCAGCGAGAGAGC +GTGTGGCGAAGAGAGACGCAGGTCCCTTCGCTACGAGATATTTCCCGCCA +GAAAAGTAGCATTCTCATGATCTCATGGTCCCGTAATAGTGACAGCGATA +TTCCATTTATTTCACTTCAAAAATCGAGATGCCGTAAATCAACACAAGCG +CTACTGTCATTTAAAGAATTACTTTAGTTTTCGCTACGAGATATTTTTCC +CGTCAAATATGTTGTGCAATACGCATTCTCAGAAGAAAAAAGAGGGGGGC +AGATAGCTCAGTCGGTAGTGGTGGCCGCTAGCAGTCTGGAGGTCACGAGT +TCAAGTCCGGCCTCACCCCCTAGGTTCACCCAGCCTCTATTGGGAAGTGG +AGCAATCCACGACTGGATTATCGGCCACAGTCCCCGGCTAGGACGTGGCT +TAAATTACAGCCCAGAGGGATCACCACCAGGCAGTGTACCTGAATCCCAG +ATCCGCAGTGCATAGCACTTGAAGAACGGATCGTCCTTTAATCCTTTAAT +CCTTTAAAAATGTAAAAAAATTTCATTGCAAAAATATCAAACTATGAGAT +TTTTTCTATTATTTTTCAGAAGAAGTTATGTGTGGTGTGACACGAGAAGG +CGGTCTCCACCGGGAGTTCAATTCAGAAGAAGTTTCGGCGAGTAAAGTGT +CGTCAATGATGAGACAAGTACAGACAGAGTCCACAGAGACACGACGACAA +GTTTTTGTGGAGATTTGTCAGCAGTATTCTCCAGTTTTTAGGTAATTTTT +CTGAAAGTTGTCGAAGTTTTTTTTTTTGAAATTCAAAAAAATTCCCAAAC +AATTGGCCTTTTTTCAAATTTTTCCAAAAAATAAAATTACAGACACTTCT +TCTACACCAACTTTTCGACGGCGCAGATTTGGCGGCAAAAAATCATAAAT +TACAGGCAGAGCTTGGCCACGTGGAGTATTGGTAGGTTTCGAACTAAAAA +TGCTAAAAAATTTTCGAAGAATTCGAACATCTCAGATTTTTTCCGAAAAA +TAATAAAAACGTTATTTTCCAATTTTCTGAAAATAAGAATTTATTAGTTT +CTTGCGAAATGAAGAGTCTCAAAAAATCATATTTTTTTTAAAAATCAGAT +TTTTAAATTCTTTTTTTAAAAGTTTTATCGTGAAATTGAACGTTTATGAA +AAATGGCGAGAAAAACTTTTTTTTCGCTTTTTCAAATAATTCTCAAAATA +AAAATTCCAGTGTGCTACATCGTTGGCCTCGGCGATCGACACGCGTCGAA +TATTCTATTCGATCAGAAATTGTGCACATTTGTGCATATCGATTTGGGAA +TGATTTTGGAGTATAGTAAACGAACGTTGCCAGTTCCCGAACAAGTTCCA +TTCCGTATAACTCGAGATGTGCTCGACCCGATTCTGATTGAAGGAATCGA +GAATGGACAGTTGGCTGAGGAATGTACGCAGATTATGGAGAAATTGAAGG +AAAATGGAAAGGTACGGCGGTCTGGGGAAATTTATACGAAAAGAAAATTT +TGGACTGACAAAATTTTGGACTTGTAAAGCTATTTAAAAAATTCAAATTT +CCCGCCAAAAATATTTTTTCAAAGAATTTGAATTTTAGCTAAATTTTTAA +ACAAAATCTGAAGTTACCGCCAAAAGTTTTCCAAAAAAAATCGAATTTCC +CGCCTAAAATGTTTTTCAATAAATTCAAATTCCCGCCAATTTTTTTTACA +CAAAATTTGAATTTCGCGTCAAAAATTTTCCAAAAAATATTCAAAATTCC +CTGAATAGTTCAATTTCCCACCAAATATCAATTTTTCTGAATAAAATTTT +AGAATTTCTCGCCAAATTTCTTTTTCAATTTTTTCAATTTCCAAAATTTC +CAGGTAATCCTCGGTGTCGCCTCTGCTCTACTCCGCGAAACGATGACAAA +TTTCCGAGAAGCCGAACAGGCTGCCGGCCGCCCGTCCTACATTTCTGAAA +TGGCCATCGGACGGCTTCGAGAAAAGCTACGGGGCACCGATGACGGTGTG +ACGGCCCAATCGTCGAATCTTCAAATTCGGCGACTTTTACGAGAAGCTAC +GAGTGCTGACAATTTATCGCGAATGTTCTGCGGATGGATGCCGTTTTTGT +AGAGAAATCAGAGAAAATTTTTCTCGAAAATTAAAATTTTTACTGTATTA +TTGTTTTCTCGTATCAATTTTTCAGAATTTGCTTTGTTATTTTATTTTAC +GCGCAAAATAATCTTTCTAATTTAGAAATTTTAAAATTATGGAAACTTTC +TGAAATTTCTGCAAAATTCTAGAAAATCAAAAAATTTAGTTTTCCATCCT +AATTTTTTTTTTCGTTGATTTTCCCCAGAAAATTCAAACTTTTACTGTAT +TATTATTTTTTCATATCATGTAATGTTTTTTGTTCAACATTTACATGTTT +TTCCTACCTCTTCTATGATTTCCCCTTCCCCCAGGTCTCATTTTTCTTCA +CAATTTTTAAAATTGATTCACTGTTGAATGTGTTGTCTTTTTTCTATGCG +AATTTTATTAATTTTATGAAAAAAATTTGTAATATTTTTGTGTAAATTTT +GAGTCTTCTTACACTACAAAGTTAACCATTTCAGAGGAGTTTCAAAATAA +ATAGTGAATTTTTACAAAAATTAGATTTTCTGATTTCAGCGTACATGAAT +TGCCCGTTTTCAACAAAATAAGACAACTTTTTATTTTTGCCCAATTTTTT +TTCAGCCATCTAATGACTGTCCTTTTTTTTTGGGCAAAAATAATAAATTT +TCTAAAAGCGTTTAAAACTATTATATTTTGAAAAAAGACCATTTTTTAGG +GCTTGGCAATTTTAAGTTCTCTAGCTACAAATTGAACCAATTTAGAGGTT +TCAAAATTGTGAGTTTTTGCAAAAATTGCCAAATTTTGCCACTTTTTAAT +GGTTTTTGATGGGTTAAACCTAGATTTTCTGAATTCTGCATATATGAATT +ACCCGTTTTTAACAAAATTAGACAACTTTTTATTTTTGCCCAATTTTTTT +TCAATGACTGTCCTTTTTTTTTGGGCAAGAAAAATAATTTTTTGGAATTT +TTTTCTGAAAATGTTCGAAATTTTTGAAGTTTCTCTTGAAGCACTCCGAA +AAACCAAACGACCAGCACTACTTGCAAAGTCCGAAAATTTAAGTTTAGAA +AAATTTTGAAGTTTTAAAAGCTCCCAAACCAGAAACTCACGATATAGAAA +TTATTTCCAAACATTTCCGAAAATTCCAAAAAATGAAAAATCAGAACAAT +TTCGAAATTTTTTTCAAAACACTTCTGAAAAAAACCGAAACTGCAAAAAT +TTGAAAATGTGCTAAACTCCAAACTGTACGATTTTCCACATTTCAGAAAT +TCCAAAATTCGTAAATCTGCCAAATCCCTTCGGCGCAATAATCCCCCGGG +GTACCCCCCCCCCCCGCCCTAAAACCTTTTGCCTCTATTGTCTCTGGCGC +AGAAAATTGAAATTAAAAAATGAATCGATATTTTAAACTGTTATTCGTAG +CCATCTTCTCCGGATGTATAATCGCCTACACGAATCTATTCAATCGATCG +TTTTTCAACGGGTACTGTAGTAATAATGCTACGTGGCAACAGTCACAAGG +CGAAAGCGACAGTCACGTGGCAAATTCGTTGGATTTGTGTCGTGGCGATG +GTGTGAAGCAGTGTATTCCGCCGTTGATGAGGTTCAAACAGTTGTATCGG +GTGAGAAAGATTATCGATTTTTAACACCCGTCTCGCCAATTTTTTTCTCA +GAAATTGGAATTCCCGTCACAAAACTTTTACAGAATGTGAATTTTCGAAG +AAATTGGAATGACACCCAAAAATTTTCTCAGAAATCTAAATTCTCGGCAA +AAGTTTTCTCAGAAATTTGAATTCTCGTCAAAAATTTTCTCAGAAATTTG +AATTCCCGCCAAAATTTAAATCAGAAATTTGAGTTACCACCCTTCTCTTC +AAGTAACAGTATTCAACAATATACAATTAAATAGCTTTTCAAATTCCTAA +AAAGTTTGCTGGAGTTATCAATTTTTGATTCAAAACTCGCTAAACCACTT +GCCCATGTAGAATACATAATCAATTCTGAATAGAACGCTATTTTATCCTA +TTTTCAGACATCAAAACCGAATAGCCTAATCGCATGTGTCATTGAAAAAT +CATTTTCGACATTTCTTACTGCTATTATGTGCTTTTTACACGATCCACAA +ACATTTAAAGACAGCAATCGAACACTGGATTCTGATATTTTTGGAGACAG +GTTTGCGGCAAACGAACTCCGCTGCCGACTCTCGAATTATCAATTTTGCA +GGCTTTGTAAGGATAAAAACGAATTTACCGAGTTGAAGAAGATCGGAAGC +TGGCAGAAAATGTCGATTTTCACTGTGGTTCGGAATCCGATCGATCGGTT +TGTATCAGGCTTCACGGATAAATGTTTAAGAGAAAATGTCTGGAAAAAGT +TCAAAAATCGATGCGCCGGATGTAAGACTGTGCGTTTTATTTGCTAAAAT +CTTTTACTTAAACAATTTTTTTGGAATCTTTTATTTTCGGGAGTTTCGAA +AGTATATTGGAGTTTTTTAGAGAAAAAAATATCAATTGAAAAAGGTTTTT +TGAAAGGGGGTAACATTTTTCTAGGCCACTAGGCTTTGTAAGGTGGCCTA +GAAAATAATGTAAAAATCTAGGCCATAAGGGTTTATTGCGTGATGGCCTA +TGAAAAAGCTAGGTCGCCATAACTTTTATCAGGGTTTAGGAAAGTTAAAA +CTTCGGGCAGCAAGTTTCGCATAATGACCTAAAACTTTCTGGAGAACTAG +GCTATAAAAATGTTCATGATGGTTTCAAAAAGCGGAACATTCGGTGACCA +TAATCTTCTAGAATTTTTAGGAAAACTAGGCCATTAAGGTTTCTTCCGTG +GTCTAGAAATTCTGGAATACTAGGCTGCCAGGGTTTCTAGGCCACATAAG +AAAGGCCTAGATACAAAAATTTCAGAACGGTCTAGAAAAGTGGATAACTA +GGCCACCAATTTTCTCTTCGGAGTTTCAAAAATATATGATTCATGATTTA +CTTTTTTAAGAGTTTTTTTTTTCAAAAATTCTAAACTTTTGACACTAAAA +TGCTTCTGAATTTTTGAAAACTTTGAAAATTAAATGTTTAAAAATAATTT +TTTGAAAATCTCTCAATTTTTTTTCTTCGAAAAGCTCAAAAAAACGATAA +ATTTCCACATTTTGGCCAGAATTTAACATGTTTCGTCGATAAAATGTACG +ATCGGATGCATAGATTCGCGCGGAATCCGTATAAAGGAATCGATTTCGAC +GACAGTCACTTTTTCCCACAATCTTGGTATCGGTAAACGCGCTCTATAGA +TAAAGTCTCAATGGAGCGCATTTGCATTTTGAAATTTGATATATTTGTCG +TTTCAGGAGATGCGAGTTCTCGTCTCATCTTGTCAAATACCAAATTTTTC +AATTAGACGGTGCAAATTTCACAAATCAACTTCTTGGACTGCTGTCCGAG +CGGGGAGTTGATGAGAATGGAATTAACTTTATTAGTGAGTCTTAATCAAG +TTTGGGTCTCACCGCGAAAACCGTAATTGATTGGGGACAATGGGACCCAA +GAGAGCCCAATGGAGCGGAATTGCAACTCCTATGAATTTTCCAGACGGAA +GTCTCCATCACCGGACCCCACACAGCACAATGGATTCCGTGGAACGGGCG +GCCGTCGAGGAAACTGTTCTGAGCAGTCCGTATTTGTTGCGAAAAATAAT +TCAAATGTATTATTTTGACTTTTTGCTATTCGGGTATAAGCTTCCTGATA +TTCCAGTTGGAAATTAGGAAAGTTCTTTATATGTATTTAATTGTTGTTAA +ATAGTAAAAATCGATAAATTGCTTGAATTTTGATAAATTACGGCCACGTC +AATTTTTAGATAATTAACGGGCAAAAAAAATCTAAAATTCTTACAAATTG +AAAAAAAAAATTTCACAAAAAATAATAACATTTAGTCTAAATGTGTTATA +GCTTAGGCTGAGGTTTAGGCTTGGGCAGGTTATTTTTTAATTTTCAAGGT +TTCTCATTACATACTTTATTTCCGAAATACAAAAAAGAAGTCTCACAACG +AGTCATCAGTGCGTGTTGGTGGGTGGGGTGGGAGATTCTGGTGGCGACCT +ACAACTCACAAACAAAGATGACAACAGGGAAAATGTACACGTGGCAATAT +GGTGAAGCTATATGTATATATAATGAATAATGATATGTAAATTTGCATAA +TACAGGAACAGTACGTGATTGCTGGGGCGAGTAGAAATGTGGGTTATTAT +CTATCGATTACCATTACACATGAATTACGCTGGATTACGGTTAGAATTTT +GTGAAAAAAAATGAGTAAAACGCTGGGGCTATAAATCTATAATTGTCGAA +GATGCTCAACGAGCCAGGAACGAGGGGAACATTGCGTCAAACTGGGCGGT +CAATTCCATTAATGATGGTGCAGCTTGTGCATTGATTGCTGCAGCAGTAG +GGACTCCATGCCTCATCACCGAATCGATAATCTTCTTTCCAGATGAGAAA +CGCTCGAGACGGGAGGCGTGTTGGAGCACACGCTGCTTCATTTTCTCGTA +CCATCCAGAGTAGAGAAGCAGAATAGCTGGTGGAAGTTGACGTTCTCTGG +AAAAAAACAAGATTTTCTCTAGTTGCCTTAACACTTGGATTTACAGAATT +AGTGAATATTTAAATCAGGGTGGGCGGCAATTTTTTTTCCGGCAAATTCA +GCAAATTGCCGATTTGCCGGAAGTTTTTAAAAGGATTTTTAAAAGACGGA +AACACTTAAAACTGTGCCTTTTTGAAATTTTCTCCCGATTTCTTTACATA +TTTTCATAGATTTTACTGACTTTTCAAAATAAATGTAGGAACATTTATAG +GATGCGTACAATTTTGCCGATTAAAATTGAAACTGTGAAATTTTCAGAAA +AAATGTGCCGAATCACAATTTGCCGAAAATTTTAGTTCCGACAATTTGCC +GTTTGCCGGAAAAAACCGTTTTCCAAGCCACGTGGATCATTTTTTGAAGA +AAAAAATACGGCAAATTTACAGAAACTTTAGTACCATGTGGATTTTTTAA +GAACTATTGCCAAAGTACGTGGAATGTTCAGAAATTTTTTTGCCTTTGTG +AAATTTTGGATTTTTCTGGATTTTCGGAAAAAAATTCAAATTTTTCTATG +AAGACGAATTTCTGATTTTTTTAAAAATTTTTCACGAACTCAAATAATAC +TCAGACGCGAAATTTTACGTTTTCCGATCAAAACACGGTACCCGGGGTCT +CGAATCGACATGCAGTATTTTTCTCGCTTTGTCATAGTTTCTCGATAAAA +ATGGATTTTTTTGAATTCAAAATCCTTAAGTTTCTACCCAGGGGAGAAAA +AGAAGACTATAAAAATTTGAAGTTAAAGTACTCTTTAAAGGCGCCCTTTT +TTCGAACTTAACCAAAAATTGTCGTGTCGAGGCCTGGTACCGTATTGTGG +TGCGAAAATCATTTAAAAAATTGCGTCGATTTTTGGTTTTTTGTTATTTT +AAAAAATGTTCAATTTTTCAAAAATAGCTTTTAGATAAAAATAATAGGTT +TTTCCTTCTTTTTTTCCGGCTAAATAATTTTAAGAATCCATTTGCCACGT +TTCATCACAGAAAAAAAACTAACTCTGTGCCAATCAAAGCGGCGGTGCAA +ATCGAAATCATTTGCTGAACGACATAGTTGCCATACTGGTGGAACAGAAG +AATATCCAACGCATCACGATTCGACTCGACATCCTTCACATATCCACTGA +AAATCTCCTCCATCATCTCGTGAAGCAACGCGGGCGGTGCAAACAAGAAC +GCTCCCTCGATGACGTGCGACGCATACTTGTCCTGTGACATTGAGAGCAA +GTTACGGAGCAGGCATTTATCGATGATAGTGTCTCTGTACATTTCCATGA +TACCCGACGATTTGATGACGTATTGGATGACGTAGTTGGCGAACTCGTTG +GAAGACAGCCGGTAGCAATTACGGACGATACACGTCATCAGAGAATGCAA +CAATTGAATACGGAATTTGAAACACGGGAGCTTGGGATTCTCGGCGAGTC +TATCGATGACCTGTTGCACGAGACGACATCCATACTTGTCCTGGCACACG +GCCATCAGTGAATCTCCTGACGAGAGGAAATGCACGAAAAAGGTCCACAT +GTCGACTGGAAGTTGCTTGACGACACGTTGAATCACGTGGATCGAGATTT +GATCATCCAAGAGCTCAGCACATTGCCGCCAGGTCGAATGTGCTGAGCTC +TTGGATGAGCTGGAAGACGTTGGAATGGTCGAATTTCTGAAATTAACAAA +TTATTGATTTATTACACCTGGAAAGGCCTAAAAAGACCAAAAATAGCCCT +AAAAATTTCGAAGAAATGGATTAATTTTTAGCTAAAACGTAATTTTTTGC +CAACTTTTCTGTGTCGCGATTTTTTTAAACCAAAATCGAAAAATTTCGTT +TTTCGATATTTTGAACAAATTTCAATTTTTTCGGGAGAATATCTTAAAAC +TTAATTATTTTCCTCTAGGAGCCATTTTGTATGTTTTTTTCATCGACAAA +AAATTTTCGTTAATGTGTGCACCTTTAAGTAGTACTGTAACTTTAAACTT +TCATTGCTGCGGAATTTTTTAAAATTGATTTTCAATGTTTTTCTACAGTT +GTCGTCCAATTTCATGCAATTTAGAAAAAAACAGAAGGAAAAAGTGAAAC +ATCGATTTTAAAAAAATTCCGGAGCAATGAAAGTTCGGAGTTACAGTACT +CTTTGAAGGCGCACACCTTTTTTGTTTTAACAAAAATTTGTCGTGATGAG +ACTGGGGACAGTTTTTCGGCGGAAAAATCGCAAAATTTCGGCTAATATCG +AAGAAAAATCAATTTCCGACCGCTGCGACACTTTAGCAAAAAATTGTGAT +TTTAGCCAAAATTCAGTTATTTTTCGGAATTCCCGTGGCGAGACGTATTT +CTCCCACCTGCAGAGCCAACTGCACAACTCGACATGCGAATTTATCCTTG +CACATGGCCAAAAGCCCTCCGTCGATCATTTGACGAAGCAATTCCCGCTG +CTCGGCCGGTGTTGCGAGCTCGACGAGCTTCTGAACGATGAAATTGCCAC +TTCGACTGTGGCAGAGCCCCACGAAGAGCGTCGTGGATTCGGTGAGCTTC +TCGAAGACGGCTTTACGAATCTGATCTTCGGAATCCAGTGGGTAGTTGGC +CTCCAAGAACTTTACGCCCGATGGATCGATTGCGAAATCGATGAGCTGCC +CGTTGAACAGCACATCTTCGAGCGAAATGAAAATCGGAGCAACTGGTGGT +GGGGTCTCATCGTCGGAAGATCCCGATCCACTGTTGAAGATGTAGCTGTC +CGAGTCGGAGGAGGTGGTGTTGCTTCCGTGGCGGTAGGGAAGAAGCTTGA +CCGGCGGCTTTGGATTCTGGAAATTCGAATTTTAAATTTTTATTATATTT +TCTATTTAAATTAGAAGTTTTTATGCAATATTCTACCTTGTTCTTGTGAG +TTTTGTTCGACAAAAGCGAGAAATCCGGGTCGAAATCGAACGACGCGCCG +AGCATGTTGTACGAGTCTGTGCTTCTACGATTCGGGGTCATTTAGACAGA +AATGAATGAATACAGGTTAGTAGACGCTGAAAAATTTTGGGAATTAGGAT +TTTCAACGGAAAAAAGAGTGAAAATGAGAGGAAAACATGTAAATTTCAAC +GAAAATCGCGAAATTACCGCGCATCAAAATTCAAAATTGAATTTTTCGCG +GTGGCCCGGGTTACGGTGATTTTTAAAGGCGCATGGTTGTTTTGAGTAAG +GTCTTGACGCGAAATTTAAAATTATTGAACATTTTTATTTTATTTTTACA +TTTTTAAAGAAAAAAATGATTAAAATTCGATTTTTTAGGAGAAATTAAAC +ATTTTCACAAAAATTGCAAGAAATCGCTCGCCAAAATTCGAAAATGAAGA +GTTTGGCGGTGCTCATGGATTACGGTGGATTTAAAGGCACATGGCTTTTT +TGTATTAGGTTTCACCACGAAACTTGGAGTTTTGATAGTTTGCTTCCCAT +TTTGGGATTTATTTTTTTAATTTTCGCTCGATTTTCACACATTTTCACTC +ATTTGCACTCAATTTTTTTGCAGAAAAATGTCAATGGATATTGTTATGAA +GTCAGATGAGCAGCCGTTCATCTCTGCGCCTGTATGCTTTAAGTAAGCTC +CAATTTTTGTTATTCTGGCCTAAAATTATTTTTTTGATTTCCAGAACGTT +CGCATTTTTCGCCAAAGCATCCGCAGAGGAATGCAAACTTCTCTTCGGGC +TCCAACGCTCGAGAAAGTTTCCAGCAGGCCACGGGGCTCTCGGAGAAGAT +CACGGAAGACATTTACCGCCAAATTGAGTAGGTTTTTCGATTTTTTTACC +CTTAAAAACTACTATTTTTCTATTTTCCAGCGTCTCCCACATTTCGTCGA +TGGTCTTCAACAGAGAAATGGACGGTGGCATCGAGAGAAATCGGCTCGGC +TCGCAAGCGATTCTGCTCGACGAGAACTCCAGGCGCCGCAATCCACAGTT +CAAATCGATCGCGCTCCGCTCTCCGCTACGATCACATCGATCATAGAGCG +TTGGCAAGGAAATCGCCTCATCTGATGCCTCCGACTTTTATCAAAGAGGA +AATTATGGATGATGAGCTCGACGAGGTGAAGGAAGAAGTGGTTTCCGTTG +GAGAAGCCGCCTTGCCCACGCCAAAAGTCGAACTGAACATGGACCATCCG +GAAAAGGACCTGATCATCAGCATTTCCGTGTATCTCGGCTACACCCGTAC +CCTTCAATACCACGAGATTCGCCTCGGACGTTTGATGAAGATCACGGATC +GGCTCGAGCTCACCGGAGATCACACGCTTCGCGATCTGAAAAACGCGTTC +TCGTGCCCCATCGATTTCTCGTTTTCCGACGATTTTAGCGAGAAAAAGCC +GTCGTTCAAGGATATGGCGAAAAATAAGTGGCCGTCGACGATGTTCTTCA +TTCATGACACGTTTTATATATAACTGGAAATAATTTAATATTTTTCGAAC +AAATTTGAAAACTATAAAACCATCTTATTTTGATAAAACTCCGCCGCTGC +TCTCTGAAGCAATGAACTGCAATCAGACATCGAAGGGATCAGCCGATCAC +GGAACCAACCTGCCATTGAGCTTCTGAAAATTAATATATTTGATTCAATT +TATTGTACGAAATCGTTTTTACCCATATCTGTGAGCTAGCAAGCTAGCTA +ATCGTGATTAATTGTTGGGTATTCCTTCGCGTTCTTCAGCTTCTCCACAA +GCAAAATTCTTGTCTGCTCATCACAAATGATGTCATCAGCATCGCTCTGA +TCTTGAAAATCCTGAAATTATAACATTCTAGAGGGTTTCTGATGAGAATA +GTTACCTTACAACCAACACCAAATACGTTCTTCATTATGGCATCCGGCAG +CTTTCCATAATCGCAGAAGAAGTGCTCGGCATCACGATCGGATGCTCTAT +TTGGGAAACGACCGATGTAGACACGAACCATGTTGAGTGGCCGAGAGAGG +GATCATCTGAAACATTTAAATGTTAACTAAACAGGAGTTTAGAAACTTTA +AAACAACCTAACCTCCGTGATAACGTAGTTAGCTTCTCGAGTGAGCTTCT +TCTTCAAAATAAAACAGAATGAAACAAGAATCAAGTGGGTAAAATTGTAA +AATGAAGTATTTCAGACATTTTCGCTAATTTTGGCAGTAAAAACCTATAA +TTTTGGTAAAAATCGCTTGTATTCTGAAAAAAGAACTCAATATTTAATTT +TTTATAACTGATTTTAAAGAGAAACAAACGAAATATATGAAAAAATCGAA +AAAATCCCTGAAAAAGGCCTCCGCAATATTGATTGTTAAAGGGACACCGA +CTGTTCATCGAATGGGTCCCGCCGCGATTGTCCATTTCGAGCGCTTTTCG +CGATTTTTTACTACTGTAAAAAAGTGTAGGAAAATGTCGAAAAATGTCGA +AAAATGACGTCACAAATGTATTTAAATACATGTTTTTATTGTTACTTGAA +TAAGGCAAAATATGTATTTAAATACACTTTAATTTTCCGACATTACTTGA +ATAACCCCATAAAAAACCCCGAAAAAATTTTTTTTTTGTGAAAATAACCA +GAAAAATACATGTTAAAACAATTTTGTGAACAAAAAACTAAAAAATATTT +TTTTTGCAGAGATGAATCCCACGTGAACGTCGAATTTCCACGCCGCCTCG +TCGAACGGAATTTCAGAAGAATCGCATGTGACACGTGCAAGGAGGCGTCG +GCTCAGTGAGTACAGAAAAATCCATGGGGATTTTTTAGAAATTCGGAATT +GATTCGATTCAATAAAATCGATTTTTATATTAAAAAAAAGGATTTTATTG +GTTTTTAAAAAATTTAAGAAAAAATTACAAAAAATCTATAAAATCGATTT +TTTATTTAAAAAATTGAAACTCAATAAAAGTTCTTTCTAATTTTAGAAAA +ATCGATTAAAAAATAATGTTTTAAAAATCAGTAAGAATCGATTAAAAATT +CAATTTCATCGATTTTATTTATTTTAAAAAAACTTAATTTTTATGAAAAT +CGATCATATCGGAGTCCAAAAAATAATTGGGAAAAAACTAAATTTTCAAG +AAAATAATCGAAAAATTTTAATTTTGTTCAAATAATTGATAAAAACTCAT +TTTTTAGGTTTTTTTTCAAAAAAAATTTGAACAAAAAACACATATTTCTC +GAGCTTTTTTTCACAAATTGACCCGATTTAAATTAAAAATTCATAAGCTA +AAAACCTTCTTTTTTTAACCAAAAAAAAAACGAAATTCCCAAAAATCATC +AATTAAATCCAATTTTTTCAGCTGGATGATCGTCGACCACGACAATCTGC +TTCCCAACTCGCCAGGCTATCTGTGCTCTTCGTGCTACAAGGAATTCTGT +TTCGACGTGAACGGCAACAAAGTGTGCCAGTTTAAGGCCGTACCGTATTG +CGATCGAAAGGACATTGGCGACGGACGCCAATTCTTCACCGAGCTCGATC +TTTAGAGAGCGAAATTTAAAATTCTGTATCATTTTTTGTTGTTTTTTTTT +ATGTTTTTCGATTTGATTGTTTAATTATCAATTTTTGGCCTGTAACTGTG +TATTTGTTGAAATTCCAAATTTCGTTTTTTTTTTAAATAAAATTTCTGTG +TGCAAAAAAATTTATCCAATAAATAAACGGAATATATCGATGATATGGCA +AGTAGGGGGAAACGGACGGGAAAATGATTATTTACAGAAAGGGCGCGCAC +CAGAGGTTTCTCGGGGGAGCCCCGAGGCGGGTGGCGGAGCTTGGCTCAAA +ATCTGTCGGAAAAATGGGTGAAATGAGAGAAGAGGTAACCTAGAAAATGA +GATGAGAAATTCGGAAGTTTTGGGAAAAAAAAATCAACTTTTGAACAATT +CAATTGAAAAATCGATAATATTGATTTTTTTAAAATTCTCTAAGATCGAT +AAATCTGGTTTGGAAAAATCAATAAAATCGAATCTTAAATATCTTTTTAA +AAAACTATTTTCAAAAATCAATAATATCGATTTTTGAACAATTTGAAAAA +TCGATAATGTTGATTTTTAAAATTAAATTTTATTGATTTTTTGAAAATCG +ATTATATTGTTGATTATTGATTTAAAAATCACCAGAATCGATAAATCTGA +TTTGGAAAAACCAATAAAATTGATTTTTACAAAAATCAGCCAATAAAATA +GATTTTTTATAATCAAAAAAATCTATTTTTAAAACCGAAAAAATCGATAT +TTCAAAAATTGAAAAAAATCGATAAATCAATAAATCAATACATAGGTGAG +CTCGTCTCGTCGATTTGTGTTTTTGTGATTGGTCCCGGCTGCTTTTGAGA +TGGCCTAGGCGTTGTTCCGTATGACATTCTGGAATTTTTTTTTGTTGGGA +ATTTGGCACGCCCACAAAATGGACGGTGGCGGAAATTTAATTATTTTAAA +TACCTTTCTGGATAAAAAAAATCGATTTTTCCACTTTTTCGAGTGAATCG +AAAATTAAAAAAAACATTCAAAATTGTTTAGGGTCTCGCCACGAAAAACT +CACAAATGCACGTTATGCGGAGTGTCGTCGGATTCCGGTGTGTTGCTACG +GATCGTGTCGTCCATGCTCAGCTTCATCGTCGATTGACGTCGCCGTTTTG +TGGTGATCTGAGCGAGATTTATTGATTTTTAAAGGCGCATGGCCTAGAAA +ACACAACACTTCGGCCACGGACTTTGGCGGCCGAGTTTTCTAGGCCATGC +TGCGGCATTTAAAGGCACATACCATGATAATGAAGATCGCCAATCCGAAA +ATGATGACCAATGCGAAAGTGATAATTACAATCATCGATGATAAGGAATA +TGATGAAGTTTGCGTGGAAATCGAATCGATGTACGCTTGTGACGTCATTC +CTGGAAATTATTGATTTTTTTTTGGAAAAAAATTAATAATTACTTACCGT +CAACAGTAACACTCAACGAGTCAATTTTGTAATCCGAAATCATAGAGTTA +TTGCGTGAAAATGCGGCTTCCAACCTGAATGTTAAAAAAAAATCTATAAT +ATCGATTTTTTGAAAGTTTTTCGAAAAATTGATAAAATTGACGATTGATT +GTTTGCCCATAGAAACAGATAAAAATCGATATAACTTAATATCGATTTTT +TTTTGTGCACCTTTAAAGAGTACTGTAACTTCAAACTTTCATTGCTGCGG +AATTTTTTTATCGGTTTTTACAATTTTTTGTACAGTTTCCGTCCAATTTT +ACAGAATTGAACAACAACAGAAGGAAAAGTGAAAAATCGTAAAAAATGTC +CGCAGCAATGAAAGTTTGAAGTTACAGTACTCTTTAAAGGCGCACACCTT +TTTTGTTTTAACAAAAATTTGTCGTGGTAAGACTGGGGACCGTTTTTTCG +GCGGAGAAGTCGCAAAATTTCGGCTAATATCGAAGAAAAATCAATTTCCA +ACAGCAGCGACACATAAAAATTAGCAAAAAATTGTGATTTTAGCCAAAAT +TCAGTTATTTTTCGGAATTCCCGTGGCGAGACCCATTTCTCCCACCTGTA +GAGCCAACTGCACAACTCGACATGCGAGTTTATCCTTGCAGATGGCCAAA +AGCCCTCCGTCGATCATTTGACGAAGCAATTCCCGCTGCTCGGCCGGTGT +TGCGAGCTCGACGAGCTTCTGAACGATGAAATTGCCATTTCGACTGTGGC +AGAGCCCACGAAGAGCGTCGTGGATTCGGTGAGCTTCTCGAAGACGGCTT +TACGAATCTGATCTTCGGAATCCAGTGGGTAGTTGGCCTCCAAGAACTTT +ACGCCCGATGGATCGATTGCGAAATCGATGAGCTGCCCGTTGAGCAGCAC +ATCTTGGAGCGAGATGGTGATCGGAGCCACTGGTGGTGCAGTCTCATCGT +CGGAAGATCCAGATCCGAAGGTGTAGCTGTCAGAGTCGGAGGAGGTGGTG +TTGCTCCCGTGGCGGTAGGGAAGAAGCTTGACCGGCGGCTTTGGGTTCTG +GAAATTCTATATTTGAATTTGAAAATCAACAAAATTCAATATTTTACCCT +GCTCTTGTGAGTTTTGTTCGACAAAAGCGAAAAATCCGGGTCGAAATCGA +ATGAAACGCCGAACATGGGGGCCATTTGGACAGAAATGAATGAATACAGG +TTAGTAGACGCTGAAAAATTGGGAATTTCAATTAATTTAGGATTTTTTAA +CGGAAAAATAAGTGAAAATGAGAGGCAAACATGCAAATTAAAATCGCGAA +ATTACCGCGCTTTGAAAGGGACTCCACCGATCGGAGAGACGAGGGAAGTG +GAGAGACGCAAATCGAAGAGACGCCTTTTCAGACATTTTTTCGTGATAAT +TTTGCATGAATTGGCAAGTAGAGCTTACACGTGATGCGAATCATTGATAA +AAACATCAATTGTTGTTTTTAGTGTACTGAAATTCCGGCACAATAGCTCT +CGTAAATCGACACAAAAGTCACTCCGTGGAAAAGTGGAATTTGGATAATT +TTGTTCTTTTTTTTAAATATGATTAACGTTTTTGAAGGCTTTTGTCTCAT +AATTCATCAAATTCAAAACCGGAATTATCCAAATTCCACTTTTCCACGGA +GTGACTTTTGTGTCGATTTACGAGAGCTATTGTGCTGGAATTTCAGTACA +GTAGAAACAGAAAATGTTGTTTTTATCAACGATTCGCATCATGTGTAAGC +TCTACTTGCCAATTCATGCAAAATTATCACGAAAAATGTCTGAAAAGGCG +TCTCTCCGATTCGCGTCTCTCCACTTCCCTCGTCTCTCCGATCGGTGGAG +TCTCTTTTGAAATTCGAAAATAAAAAGTTTCGCAGTGCGCCCGGGTTACG +GTGAATTTTAAAAGCGCATCACGGTTTTGAGTGAGGTCTCGACGCGAAAT +TAGCCGTTTTTGAAGATTTGTCGTTTATTTTGGCATTTTTGAAGGAAACA +TAAGTGAAAATAAACAATTTTAATCTTAATTGAGAGAAACTTGAACATTT +TTACAAAAATTGCAAGAAATTGCGCGTTAAAATTCAAAAATTAGAAGTAT +CGCGGCGCTCAAGCCGTTGATAACAAGCCGTTATAAACTTATATAACTAT +ATAATGTAACTCGATGATTTGTTGATGTGATCTTTAAAAAGGTTGAAACT +GCCCCAGTCGATGTCCGCGCCAGAGGCGCTGTCAGCGGCTGGTTACTTAT +ATATAAAAAATATCGGGAAAAACGCACTTCCGTTCCATTTGTTTCTTTGT +TTTTGTGACGTCACTGAGAATTATGGGCGGGCCCGTCTGCCTTCGTGGTA +AGACCCATCGTGGCGAGACATATCGTGGTGATATCCTTCGTGGCGAGACC +CATCGTGGTGAGACCCATCGTGGCGAGACCCATCGTGGTGAGACCCATCG +TGGTAAGACCCATCGTGGCGAGACCTTTCGAAAATTTGGTGGGAATTCAA +ATTTTCTTAGAAACATTTTTTGGTGGGAATTCAAAATTTTCAAAGAAAAA +CTTTGGCGGGAATTCAATTTTTCAATAAATAATTTTGGCGGGAATTCAAA +TTTTCTAAGAATAATTTTGACGGGAAATTCAAATTTGTTGAGAAACTCGA +GTAAATGCTGGAATGTTCTAGAACCTTCCTGGAGATTGGGGAAAATTTTA +GTATGTTCTAGAACCATCGGCGAACTTAAGAAAATTCTGGAAAGTTCTAA +AACCTTCTAGAAAATTCGTGAAAATTCTGGATTGTTCTAGAAATTTCTAG +AAAATTCGAGAAAACTCTGGAACGTTCTATAGAACCTTCTAGAAAATTCG +GGAAAATTCTGGAATGTTCTAGAAAATCTTGTTTGCCAAAAGCTCTCGGA +AGGAACCGGAAAAGTTTCTTATGATTTGAAGAACGTCTAGAAACGTTCAA +GAAATTTAGAAGTAGTTCCAGGAAACCTGGTATTTTTAAGTTGTAACTCT +TGAAAACTTAGTTATATAATATTCATGTTGCGTTAAAAACTTCTGGAAAA +CTGAGAAAAACGTTCCAAGGCTTAGAAATTTTAGAATTTCATCTTAATTT +CGAGTACGCCAGTCGGAGCACGCGCATTGTGCGAACGGCTGGTATACAAA +CAATAGTCAGTCAATCCCATGGATCAAATTTTGAATTTTTCTAAGACTGA +ACTGTTCCTTTGATATGCAAAATTTTATAAAATTGTCTGTTATTGAAAGA +CATGAAACAAACTTGAATTACAGTAATTCTGTAAATTCTGAACTTACTAT +TAGAATCCTTAGTGAGCACACTTGAAAACGAATGAAATAAGGTATGTGAG +AATACCGTATCAATCAGATACGTCTGACACTTCCCCAAAAAAAACTATCA +GAATATGAGTACGATATGTTATTACTAGTGTGCATCTTTCCGCGCGACCA +TCATGGCTCAGCAGGTAAGACTTCGGCGACGCCTCGAGACGACGAGGTAG +TTGACGACTTTTTTCATTTTTTAGGCAGCGCCCAACTCTTGTCCGAGGTC +TACAGGCTACATGGTTTGGACGGACAGAGTATTTGCTTTATTAGTAGTAA +CAGAAATACACATAAAATCAATTAATAAGATCCATGAAATGCAATAAAAA +TCCAGTTTTCACCCATCTACTATGTCTCTCATTGAAGAACTTTTTCAGAT +AGCTTTTGGTATAGAATATATTAAAATTCATTCTTCGATTTTCTGTGGAA +TTTCTTATTTGAAAGCTTTTTCCATACCAGACAGTCACTTCTCCAAATCC +ATCCTTGAAATTTTCTTTGGGGATATTTAAAATATCATCGAGATACCAAC +AATCTACTGGTTTTTCACCTACAAGACGTGCTCTTGAATTGAAAATGTCT +GGGATATCCTCTGGAATATGTTTTTCTCCTTTGTCATGCTGATAGTATAA +GTTGAATGTGACACTTCCATTTCTCTGGCTGTTTTGTTCAGTCAATCGGA +TTAGCTTTGCTGTGACTCTGTCCATATTGTCCGGAGTAATGAGGAGATAC +GTTTTAGGAAGTAGAACAGTCATACTCTTGGCTGGGAAGTTTCGTTGAAC +ATTTGCAATCACATTGTCCATTGGTGAATAATAGTCGTTTTCCAGTTGTT +CGTTCATTTCGAGTAACATATCCTCAGAGTATTGTAAATCGATCTCCACT +TTTTCCAGAAGAACCCTCGAAACGGGTTGGGTGTTGAATGGTACATTGAA +TACGGCATTTGAAAAGTCTTTAGACGTTTCCAAAATGAAATCCATATTTG +AACTAAACATAGTATTAAAATGACCACTGTAAGCTTCGAACCGGAACTCC +AGTCTGAAATCCTTAACATTCCACTTTGAAATAAGCTGGTATAAAAAGTC +TCTTGGGATTGAAAGGAACTCTTTTCCCAGTATTAAAACGGTGAATGTGT +GGCATGTTACCAATGAATTGAGGAAATAATTTGCTCGAGCACCAACTACG +TACCGCCCTAGTTGCTTTTCGTATATGGTCCGATAAAACAACCTGTAAAA +TGTAATCTTTATAATGTTCCTGAGCATATCATGTCAAGAGTGTCTGAGTT +TTTCATCAACAAAAACAAAATTTGATTTTTTTGTTAATTTTCTAAACAAT +CCGATTTTTGGTTTTCCGGAAAATTGAAACATCGAAATTTTCCGTTTTTC +AATATCCAATTATTCGATTTTCCGATTTCCTCTCAGAAGAACGAAAAAAA +CGAGAATAAAGTTTCCATGACATTGATCGCAGTGGGCTGTTTGTTTTTGG +GATAACTTTAAGTGAAGGAATGGAGAGACTATCTAAGTATGAAAAACACG +AGAATTCACTCTTTTGAGAACCTGTTACAATACGTGTACTGTTATAATAG +AAAAACTAAAGCAGTGATTCAAACATCTGTTCGACGGTGTTCATTACAAA +TGTATCAATTTACACTCACCAGTCTTTCATTTCCAGCGCTTTGTAATGAC +GTGGAGATATCCTGATTTGATTTATGATTTCTATTATTTTTAATTCTCCA +AATAGCTCTTCTCCCAATATTCGCAACTCATCAATTCCAAAATTGCTCAA +TCGAAGATATGCGAATTTCCCGAATAGTTCGTTTAATCTGTCCATAAATC +GATCATGCTCATCAACTCCAAAATTTTCCAACATCAAATTCAAAAACTGC +TGCGGTATCGAATTTCCACCAAAATATTGAAGTTGAATACTATGAACTAT +ACAGTTTTTATTTCTATGAATGTCTCGACATATTTGACAACCACAGCAAA +AATCATTTTTATATTCTTCAACGAGTCCATCTAAAAATCATGAATGTCAA +ATCAGTAGTTCAAAAGCCATATATTTTACTCAGAATTCTGAAAAACAGGC +GCTCATGTCAAAAATTGACTTACAATCTACTCCAATCAAGCAATCGTGTA +TGAGATCATTGAGTATAATTCGAGCATCCACTCCGCACGAAATTTCGTTT +TTCTTAATCGGTTCGACATAAAGCTTGTAGACTTTCACATTTACCGTATT +TTTTAAAAATCTGAAAATAATGTTACAGCTGAGTACAAAACATTAAAAAT +TGGTTTAATTGATTGAAATTTTCACCACTTCTCATATTGTTTCCACGATC +ACAAAAAAGCATAAAAAACTTCAACAGACTCAGAAAACACTTTTTAAAGG +CAAGTTTTGAACCACCTATTTTGATGAAAAATTGTCTGAAACACTTCTCA +GATCGACTTTTCCCTAGCTCAAAGTGATCCTCTGCCGCTAGCTCTTTTTT +AGAGTGGTCATTCGAAAGTCCGGGTTTAAGTTGAAATATTTCCCTTACCG +GTCAAAATTCTATCAACATCAAAATAAAATTGAATTTTTTGGTAGTTAAC +AGAGGAAGCGGCGAGCAAAAAAACCAGGTTTTGAACAATTGATTTCAACT +TACACGAATAAGTGTTTCACCTTGTTTTTGTTTATCTCCAGTGCATTTAT +AAGAAACGAGCAAGTGCATCGACGAAGCTGTTTTAGCGGAAGTTCAGGAT +CTACTTGATTGTTAATGAATATTGATCTTTTTCTTCAATTTTTACAAGTT +TTGAAACTGTGAATTTGTATTTTTCGATGCTCATTTCGAATTTTGTGCAA +AACTTCTTCGCTGAACAATTTATTTATCAGCTGAAAAAAGAGCGAATTAA +AGTAAAATTGAACACAATTTTGATACCTGTCTATAATTAGGGATATCAGT +CCGCTGTATTGATTTTTTTGTTTGAAAAACTGAGTTTTTGTTTATTTGCA +GCGGCAAATTTTTATTAATTTTTTTTGATAAAAGTTCATCAATGCCATCA +GTGTTGTGGCACCACGGAGTGGCGGAAGACCGAACCCTTTAAGCCTCAAG +AGGAACCGAGCAACGAAGACTATGTCAGAGGTGCAGCATGGCATCGTCTA +TTTGTATATGTATTGGAAAGAACAGAACACAGTTTCAATAAATATGTTTA +TTACTCCAAAGGGGAGATAATCAACAGAGGGGGAGTGGGTCGTACACAAG +AGAGAGGGAATTGTCTGGTGTGAGAATATCACGTCCTGCCACGCGGGTCT +TTAGTCTGAAAAGGTCGAGTGTATGAATAGTCGGGGTCTTTGCAGACTCG +TAGAATAATGTCTTTGGTCAACTACACTTTCCAAATAAAGGGAGGGAAAG +GTAGGAAACGTCGGCAATTAGTCTGACTGGGAGCTGTCAATAACGGGGGG +GGGGGGGAAGAGACCAGCAAAACCGAACCAAGAGTGGGGAGGAGAGTTCC +TTTCCTGGTGCCACCGACGCTGCAGCTCGCTCCGTATCGTCGCTCATTGA +GTCGCCGCGCAGCCAATCGTTGCTACGGGGCGCGAGTGTAACTCTCGTTA +GAGAGCGTGTGGGAGCAAGAGACGCAGAAATACAGTAAACTTCTGCGACT +CCTAACTGTATGGTAAGCTTAAGAGCTGGTCTTAAAAGGTCGAATTGAAT +GTACCCCTCGCTCGGAGAACTGCTGAAGCAGTCGAGAGCGAGACATTGTG +AAATGGGCGATACAGCAGAGCCCAGTTCACAACTCTCCGGGGGGCGGGAC +TTGTAGGCTGGTTCACGTAGTGAACTTAAGGTTTGAAGCCTTCCTTTGCC +TTTCTTGGAAGAGATTGGCGGAGTGGAAGGTCGTCTGAGCTCCTGGCTTC +TTTTCGTGAGCGTTCAGCTTCTTTTGAAGATCTAGTATTAGGTGAGCTCG +GAGCTTCTTTTCTAAATCTTGCTTCGTCTGAGCTTAAAGCTTCTTTCCTG +GATTTAATAAATTTTAAAGATGGAAGCATAGGTAGTGAGGGTTCAGGAAA +GTCGGAGTCCGTCTCTTCGTCTTTTTGTGGAATTTTGTCTTTATTGTCTA +TGTCTTCCGCTGTAACCTCAAGAGGATACAGTTGATTTAGTGATCGTTCC +AACGTGGAGTTATTGAAACGAACTCGTGCCGATTCAATGTTTCCTTCTTT +ACTCGGAATGAGCTCCACAATTTTGCCCAGAGGCCATGTGTGTCTTGGCA +ACATTTCTTGTCCGACGAGAACAATGTCTCCTTGTTTAGGATCTCGAGGA +GCATCCCTTGTATTAGTCTTTTGTCTTTCTCTCAGAAACAGGAGATATGA +TGTCGACCAGATTTGCCACAACTTTGCAACTGTTGTTTCAACTCTGGCTA +AGTGTCTTCTCGTGATTTGCTCTGTTGATCGAGCTGTCTTTGGAGAATAT +TCCATCGGTTCGTCTAGATCAACTTCATTCGGTGCATCTAGCTGAACTTT +TGGTAGTAGAAAGTCGATTGGGCGGAGAGCCGTCAGATCATTGGGATCTG +TGTTGTCTGGTGTAAGTGGACGGTTGTTAATCATCCCTTGCACCTGTCTT +AACGTGCTGGACAGCTCGAAGAAGGTTAACTTTTTTTTGCCAATAGTCTT +GCGAAGTTGGTGCTTCGCAATTCCAACAATCCTCTCGTACACTCCACCTT +GCCAAGGGGCGAATGGAGTGATGTTGTGTACCTGAATTTCGTATTTGGCT +AAAAAGCAAATCATTGAGTTGCTTGGTGCGTAAAGTCTGATGTCTTGGTT +GACCATTTGGTGGCCGAGTGTAAATGTTGGTGCATTGTCACAGTAGATAT +GGGGCGGAACACCACATGCACTGGAGATTGCTCTGAGTGCGAGCAAGTAG +TTGGCTGTAGTAGCGTCTGGAATGAGTTCTAGAATGGTAGCTCTAGTCTT +CAGACAAGTGTAGATAAGAGCATAGGCTTTACCTAGCTTGTCATCGTCTG +TCTTGTATTGTATTGGACCCAAATAGTCGAGTCCTACATGGTCGAATGGT +GCAGAAGGTACAGTTCTGCAGTTTGGTAGTCGTGTGTCGTAATTGTATTT +AAAGGGTCGTGCTTTCACCTTTTTACAGTTCACGCACTGAGCAATTGTAG +TTCTTGCAATTTTGCGATCATTTCTGATCCAAAAGTGCAGTCTTACCGTA +GTTGCCAAATAGTGTAATGGTAAGTGGGTATTTCGTCTGTGGACATCTTC +CACAATTAGACACAATCAGATGTGGAACCGGATTGGGTCCCACTATCCAA +TGATGTTTGTTTCCGTCCTCGTCTACTGGGTTACGCAATGTGTCTTGCAA +AGTGATTAAGTAACCGTCTGTAACAACTGGAGAAGTTGTGTCAAAAAATG +TCTGAATCAGTATGATTTTGTCTCTGTCTTTGAATTCGAGAATTCGTATT +GTCTTGCATTGACTGAGCATAAGAACAGTTTCCTGTTATATGACTCGGTG +ACGAGCAAATCGTGCATCTACCATTGTTGATGCAGAAGCGTTTGACTTCA +ATCGCACCCATTGTGCACGTTTGAAGTGGATGGTCTTTTTTGCAGGGAGG +GCACGGATCTCCATCGAGAAATTCTTGCCAATTCTCCACGAGTCTGGAGG +TAGTATTACCCGTCTTTTGTTGAATATGCAGGTTCAGGAGGTTTTCCTTT +AGTTTTCTGTCCCGTTGGACATCAACCAAAGTACGTCGCCAATCTTCCGC +GCAGTTGTCTTCAAGATGTTTTTTGAGGCTTACGATTGGATCGTCAGCCC +GTCTGGGTCGTATAAAGTTACGCGGAGTCAGCTCGGTATAGTCAGCTTGA +TAGTCTTGCATATAGTCTTTGAGATCTTTAATTATCATGTCTTTGGATTT +AATCGTTGAAGGTTTCTGTTTAACAGTTTCCAACAAGTCTTTAATCGTCG +ATAGTCTATGTCTCAAGTCACCAGAAATAACAATCATTTTCTGTCTGGCC +AGATTAGTCGTGGATCGTATGATATCTGTTAAATTCAAAATTGGCGTACC +TGTATCCTTTGCCTTCTCGGCGACGTCCTTGAACATCTCCTCGATGATAT +CCGGCAATGAATTGGCTTCGACCAAGTATTGAGTCAGGTCTTTGTACCAT +TTGTGAAGATCCTTGATGTAGTCCATATGCTGCTGCTTGTCACAATCGAT +ATTGGCGTTAAGCCAGTCGGATGAAGACTTATCTTTGTGCTTCAAGTCTT +CAGTCTTAAGTGCGATACGCGTCAGCAACAATGCTATGGATGATGAAGTG +GAGAATGGGGTCCTGGATTCCCTTCCCAAGCTGCCACCACCGGAGTCGGG +ATCAAGACTTCCACCTCCAAGATGAAAAGTCATTCTTCTTTGAAAACCGA +GAAACTTGTTATCTAAAATCAATAATTGGTTAAGAAGAAAGACAAAATGT +TTTGAGATTAAGTAAAAGACTTAATAAGAGATTAGGAAAGAAAGATGGGG +ATGAAGACTCAATTTGAGTGATAAGAAAAAAAGGTATTTTAATATAAGAT +TCTACAATAGGGATTGGGAAAGGTGTGCCGTGGCCTAATATAGGTTTGGT +GGTACAATAAATAGGGGAAGTAATGACCCAATATGGGTGGGGGGATTATT +AAATGTTACCTAATATGGGTGAATTATTAATTATTCCTTTGGCAGAGGAA +TGTCGGTGAGGGCTAAGAGTTCCCTGTATTGTAGGTTGATTAGTCATGTA +GGGGACTGGTGTAGAGTAATTTGGTGTAGAGTAATTTGGTGTAGAGTAGG +TATTTGGTGTAGAGTAGGTTTTGGTGTAGAGTAGGTTTTGGTGTAGAGTA +ATTTGGTGTAGAGTAATTGGTGTAGAGTAGGGATGGAGGGAATTCAACAC +CGACTGGTCGTGAATCAGATCGGCCCTGAATTGGGGTAGGGGACAATAGA +AAGAAACTACCGTGTGGCCAACTGCCCCCAGCAGGGACCTAGTTGGGATT +GTTTTCACTTGAACACGAAAACAATGGGGGTTGGGAAAGTTAATAGGGAC +AAAGGAGCAAAACGAAACGTCCATTCCCGCATCGAATTGCCTCATAGGCA +CCGCACCCAAACTCTCCTGCCGCTGCAGCAGTCAGGGAATCCGACGCTCC +ACGCTCTCCATCGCGACTGGAGACCAAGTTCTTCTTTCTTCTTATAGTCT +TTTTTTTCTAGTGGCGCCGGTTAATTACTCCATTGCCAACTAGCTGTCGG +GAAGTCAGAAGTCAAATGTCCTTGCGGACGTGGAATATAACATGTTTGAA +ATTAGGGTGGTTTAAGTTTTTTGTGAGATCCCTATGGATAAATTTTGGTT +AATTTTTAAATTTGAAAGGTTTTAAAAGATGTACAAATAATTTTTAATGA +TGTATAATTTTTGGAGAAGGTACTAGTTGAAAGATATAAAGAATTTTTAA +ATTGAAAGTTAAATTAAAATTTTGAGGGGAATTGGTGTAGAAAATTAGTT +AAAATATATTTTTGGAATTTTTGAAATTTTATAATTTTTAAGGATTTTTT +AAATTTTTTAGGAAGTTATAAAAGGGGGTAAATAAACTAACTGTTCGATC +GCCGCGTCCTCCAACGAGCAAATCCTCCATCCATCCAGAGTTCTTGTCTA +CCCGTCTTGTCGTCTATTCCTCCTTTTCTTCTTGTCTCTAGCACACAGGA +GACTGTGCACTATTGTCTTTCCGTTGCAGTCAGCGAGCTGCCAGCAACTA +GTCGCATCGTTAATGGCACCTTTGCCACTGTATTGAATGCTGTGAGCTGT +TTTAAGTGCTATTACACTATAGTCTGTAGAAAACAAGAAATTTTGTAATC +GTCTTTCGTCTTTCGTCTTGAACCATATTAACAGCCGAGATTTATTAAAT +CAAGGAACAAATAACAGCTTCAACAATGTGGTATCAGATACCGGTGAGGA +GTGGTGAGGGGGGAATTTCAAAAAATTTAAAAGATAAAAATTTAGTGATC +GAATATCGAGATATTCGATGGGGATTGTCCTCGTGCCAATTTCTTGGCGA +TCCTTGGTTGGTATCGGCGTCTGACCGGCTGGTGTTGTTGCTGCTGTTGC +TGGAGTTGTGGTGGCGGTGGTCCAAATAGTTGTGGAGCAGGAACGCGAAG +TGGTGGTGGGAACTCCTGTGCGGCTGGTACGAGTTGTGGTGGAGGTTGCT +CTTCGGATGGTGGTGGCGTGTGAGCATTGAATCCTCCAGAGACTTCCATC +GCGAGGGAGATCCTGTTGATCGCTGCGTGCACCACATCTATCTTGTCGTA +CAGAACGACGTGATCCGCGGATTGGATCCACACTTCCTGGGAGCCAGAGC +CTTGTGGAGCCGTCGCAGTCGTCGGGCCATTTGGGTCGCGGCCGGTCTGG +GGGGCTGGGCCCGTACTTCCTGGGAAGTTGAGAAACCAGTCTTCGAAGAA +CTCGGATGGAGATGTGTCGTCGGTGAGCGTCGGGTCGAACGGTCTGAGAA +GATTTTAGAAAATTAATAATAGTATATGGAAAAATTGGATAAATTTTTAG +AATTTTGAAAGAATTGATTGAAAATGTGTATAAATTGAATTTTTTAGAGA +AAAATGATAAAATTTTTTAGAGAAAATAATAATTTTTAGATAATTTTTAA +ATAAAATCGAAACTTCCTTTAGTCTGGCGCTTCGTGGATGGGTAGGCTCC +ACTCAGCTGTCAACTTACGTACTACCAATGAAGAATTGCAGGATAATGTG +CATATTAGATGCAAAACGACGAGAAATAGCGAATAATAAGTCGGGGAAAG +TCGAAATTGTGCTCTGGGAGCATGAGTTTGCCAAACTCACGTCCCTCGGC +GTCTGTGGGCTCGCGAGCCGCCCTTGTGTACGATTTTAGGGGTTTTTTAA +TTTTGAATTTTTAGAATTTTAATTATTTTTAAAGAAAGTTTGGTAGAATA +AAGGGACGGGGGATGTTTAAATAGATGTGTACCTGTCGTCTATCAAGTCT +TCGACTATCGAAAACGTCGAGTCGTCGAAGTTCATATTGAATCGTCTCTT +CACGGCCCGGCGGGGGGTACATGGACGAGAATTCTCTACCGTATTCCAAT +TTGGCTGACTGCGTGCTCAACGTTGAATACTCAGTTTAAAGTTTCGTACA +CCGTTGCGTACTGCACAGCGCGCATTTTAATTGACGAAATTTCGCGAAAA +TTAACAGAAGATTTTTTTCGGAATTATAGAGCTGAAATTGAAAAAAAAAC +TATCAAATTTTCATCGAATTTGTGAAAAATCGTAAGTATGAAGATCTTTT +CTTCACTATATTCAAGGAAAATCGATATTTCGCTTTTCACAGACGAATGA +TGTCTCATTTTACTCGATGAAAGTTTCTGATGAGCTGTTTTTATCGATTT +TTGAGCGATAAAAATGCGATTTGTTGATAAAATGGATCAATTATATAAAG +AAACAACATATATTGCTCTGAGATTACTTTTTGAGAATCAATTCTTTATT +TTTCGGTCATTTTAAATTAAGCATTAAAATAAAAATATTAGAAATCATAA +TAAAAAAAACAGAAAATCGATATATTACTTTTTCTTCGGAATTTCACGAC +TTTTTTGGACGAATTTTATTCTGTAAACTTTCTTCTTCGAATTTGTGTCC +ACGTGGCTTTCAGTCGAAGAAGATTCTGCAGCACTCCTTCTTGCTTGCCC +ACAACTTACTCGAATTTTCTAAAATTTTTAACTTATTGAAATTGTCATTT +CACCTTTACACTCACTTCAGCTAAACTATTACTGCATTTCGGAAGTTGAT +AGGATACTGGTGGAGCAACAAGTGGATGGCTTCTAGTGATTGGCTGGCTT +GTCGAGCAAGTTTGTGTGATTGCCTGAAATAATTTTTGATTTCAATTTTG +AGTTGATTTAAAGCAGTGAACCTACCACCGGGTTCGGACGAGAAAGAGCA +TTACTCGGTAGACCACGGAATCCAATTTTCGTTGAATTGCCTCCAAATGC +AATAGAAGTTTGTACGTTTTGTGAGAAGTCGGGCTGAAAATTTTCAAAAT +TTGAAACTTTTCGAGAAAAATAAAAATCTCACCACAGCATTTCGAGATTT +TGTCGATTGTGGAAGCCTTTTCCTGGAGCGAAAATTGATTTTTTTTTTCG +CTAAATTTTTTCTTTTTTGGGCAGCCGTGACGTCCCGAATAACTGCTTTT +GGGTCCCGAAGATCATTTTGCGAAGAAATTGGCAGAACTGTTGCATCTTT +TGGTACGATGGAAAGACCGGGAATGGACGTGTTCTGAAATAGTTGTGTTT +TTAAGAATGCAGAAATGTTTTTCTGTACCAAAATTACCATAGTCATGTCA +TTCATGATGTTACGACACATGAGCTCTCTCAGAACATGGATGTAACGCCT +TTTCTTGTCCCGGTAATTGCAAAATCTCCTCTCAAGTGCATTGAAAATCG +CGTGGACAGATTCAACTCCTTGTTCTGTGATCCTTCCAATGTTTCTCACA +TCTTTTGCCATTTGTGGTGCATGGTAGACCAACAAGTGCAGCTTTAAAAT +AATTGTTTCTTCGGGAACCGCTACTTTCAAATCCTCCACAAATCCGCGAA +TCGAATTTTGAAGTATTAAGACGTCGGAATCATTTAAAAACTTGTTTCCC +GAAAGTGACATAATAGTTGAAAGCTTTCCCATTGCTGATTTCAATCCGAG +CAACATTGGGCATAAATTTGGGCCAAAAATGTTGAAAGTCTCCTCTACAA +CAGCCGGCGTTAGCAGCAATTTCAAATGGTTTCCGCAAAATGATTGGAAC +CAAGCCTGCTTGTCCGCTCCAAACTTAGCCCAACACTGTCCCATTTTTTC +AAGTGTTCCTTCGGGAGTACCATTCACAATTGTATCGAGCAACAATTTTT +CCGATTGAAGTGCTTTCAGTTCAGCATGCGACTCCAATTTCATCTTTCCG +GTGGCTCCTTGATACTTTTCTTCCGCACTTTTAATTAGGTTAACAGCGTT +TTTTAGAGTTGCTTTTCGTGTTTTCAGGATAGGAAAAGAAGTAGTGTTAT +CCAAAGTATCAGAATATTTCCAGAGGGGATTGAAGATATATTTGTCAAAA +ATACCCATGATAATGTGCAGAAGAGGAATCAAATAGAACATGATCGCAAC +GTGTGGCAGAAGTGGAGTACATCCTTTGCGAACACCCAAGTCGCCATTTT +CACAACAAGCTTTGTAAAGATCGATTGTTCGTGGGTGGAATGTTTCATCA +ACATTCATATCCTTGATTTTCATCCTCTCTTCAGCTCCCCGTGGATTCTG +TGCAAAACATTTGAAGCAGAAATTGTGGGATGAATGTCCTTGGTGTCCAA +GAATATCAGATTGAAACTTGCAATCTCCAGTTGCAATTTGCACAATTTTT +GCGGTTTTTTGAACTCCTTTGTCCAAATATCAAATTTTCGTTAGCTTGCC +AAGCTGCTCAAGAACGTCCGGAATGAATTTTTTCAGAGACGAATAATTGT +CGGATCCGTCATATACTGCAATTACCATAACGTGTCTCGAAGAATTCGGT +CGAGATACGTTTCCGATTACCAATGCCAACTTTGTGCTTCCACCTCCAGC +GTCACCAACGACTCCAATCTTGATTACTCCTTTCGTGTATCCGTCGTCCA +CAAATTGATTTGAATTGCATAGAAGCTCTATTCGATAGGCTAAAACTTCT +GCAATTTTCATGCACTGCACAATGGTAATCACTTTTCCTTTATTGTCGAA +CGAAGTGGAAACTTTGAAACTGGAGATCATTGATAACTGGATTGACAAAT +CTCTTGTGTTCTTTACCGATGGAAGCAAATCATAGCCAATGGCATTAGTC +AAATAGTTTTTGATTTTTTCCATCTGACTTAGAGATAATCCGCATTTTGA +TAAAAAGTCAACGGCCTCAAAGTTTGAAAGCTTGTTTTTGTAGCTTTGAT +TCTCTTCTGAATTCAGGAATTTTGTGAATTTTCGAATAAATTGTCCGACG +TCATCCTCGAGGCAGATTTCGTGTTGAAGCAAGTGAAGAGCTTTGCGAAA +TCGATTTTTGATACAACTTTTGCTTCTTAGATTCGAAATATTAACTTTAA +AAGCTGATTTTTTAAGGTTTTCAACTTCTTCGGCGTGTCTTTGTAGACTC +AGAACCATAGCTTTGCCACTTTTCTTCACATCTGCACAGCTTCTCACCAA +TCGACCTTCTATACCACTGACGATCGTTCGTATATTGCATACTTCCATTT +GCAGCGAAGAATTAGATGCTCTTATAGTGATATTTTCATGGCGGACTATT +TGCATTTCTTCCGAAAACACCGCAAACTCATCAATCCGCTTTTGTATTTC +TTCTGATATTTCATTTTTTTCATTTTTCAGTCGTTCGATCGTTAGTCGGA +GCATTTTGATCTGCGGAATTTGCTCAACATTGGAGATTATTCGAACCCTC +GGTGTACTGAACGAGTTTCGTAAAGGTGTCGGTGGAAATACGGGATTGGA +GAATCTCAGCAAAATCATATAATATTAGTTTTGAAATATTGAAAAAAATT +ACATTGTGAGAAAAAGTCGGAATTTCGTCACTAAAATCCATTTCCACGTC +TCTCGTCAGAATTCCTTCATCCATATTGAAACAATTTGACGACCTGCATG +TAGTTGCGGAGCTACTGGAAGCAATGTCGGGATGGTGGGAGTTTCGATCT +TCTGAACTGATTTCCTGATTAGCCTGTGGCGACGAGCTGCACGTCTGAAA +ATCACGTTTTTGAAGTTAGAACAAACTACTCCAACTTAATTAAAGTTGAC +AAAATTGAGCTGAACGAACCTCCACTTTCGAATTGTTCAGTTCTTCCTCT +TCAGTTTGATCTTTTGAAACTCCATTAGCACTGTTCCTTGCTCTCTGGGC +ATTTGCTAAAAGAAGGCCTGCACAAGATTTTTCTTTTCTTTTTTGTTTGA +AGTATACTTTTGTCATCTGGAAATATTGCATGAATATTATAAGGGAAACA +ATTTTTAAATATCGATTTTCACGAAATTTGAAAAAATCAATAATTTGGGC +GCATGATATTGAGCTGAATGTTTCGAATTTAGAATCAGCATGCTTTTATT +CATATTTTAGGATCTTTTTAAAAAATCTGGACCAACAGTTTTTGAAAAAA +AAATACTTTTCGTTCAGAAATGTACTGATTTTCCACTGATTTTCACGAAA +TTTGAAAAAATCAATAATTTAGGCGCATGATATTGAGCTGAATGTTTTGA +ATTTAGAATCAGCATGCTTTTATTCATATTTTAGGATCTTTTTAAAAAAT +CTGGACCAACAGTTTTCGAAAAAATTCAATTTTTGTTCAGAAATGTGAAT +ATTCACTAAATCGAAAAAAATAATTGCAAAATCCGTCGGCTGAACATTCA +AAACTTATCAATTTGAAATCAGCATATTTCAGTGTATAATTAAAAAAGGT +TTCAAAAATTCTGAGACCAATTTTTGTTGAGAAAAATAATTTTTCGTTCG +AATTATCGATTTTTCACGAAATGCCAAAAACAGTAAACTTGGGCCCATGC +TAAAAGCCTGAATCTTTCAAATTAAAAACCAGCATGATTTTTTCTATATT +CTAAGACGTTTAAAAAAAATCTGGACCAACAGTTCTTGAGGAAAGTAATT +TTTTATACAAAAATGTGCTGATTTTTCACTAAATTCAAAAAAATAATCAA +GTTGGGCCCATGCTATACACCTAAATCATTAAAATTCAGAACCGCCATGT +ATGTATTTTTTCATACCATAGGCTCTTTAAAAAAAATCTGGACCAACAGT +TTTTGAGATATGTCAAAAAAAACAACTCACTTTTTGACGTTTTTCGCCTT +TTCGCGGATGATGCGGTCGATTTTTGCGGCGATTTGTGGTCTTTCGCTGA +AAATATTATTTTTATTTCAATTTTTAACGAAGAAAACAAGAAAAAACGAC +GAGAAAACATCAAAAAACACGAAAAAAACGTCGAAAAACTCCCGCAACCT +CATGAAAAAAAATAAAGCACTGCAGCCGCGGGACTAGTTTTCGCAACTTT +CTAGGCCATGTCCCGTTCGCCGTGCCGTGTCTTGTCGTGGTGGTGTGAAG +TGTGTTGGTGTGAAGCGTGTGAGTACGGTAGGCTGCTGCAGATGTGGTGT +GAGCTGTAAAAAATCGAAATAATTCAAGAATTACGACGATTTTCGTATTT +TGAGAAGAAGAAAATTTTAAATCACGAAAATTCGAGAGAAAAAATGATCA +AATTCAGTCTCAGAAGCGAAAAATGAACTTCTTTGTCTGGAAAACAGCGG +TTGCTCGTGAGAAAAAATGTTTAAAATTGAAGAAGATCAACAAAAACAAA +AAAAGACACGTAAATGCAACTTGTTTTTAAAGGTCGTGGCCGCGTCGCGG +TCGCGCCGCGTGCGCACTTTTGTAGAAGACTCCGCCCCCTTTTTTCTTGG +CGCCGTGCCAATTTTTAGAAGGAAGAGCGTTTTTGGTTGAAATAATCGAT +TTTCGACGAGAAAATAGACTAAATCAAGTATGGTGAATCTGATTAAAGGC +ATATTAACTTTGTAAACTGCACAATTAACTAGAAATCGTACTATAACCGA +ATATAGTCAAAGGGTCGCTCAGTTCCCCCGGTCTAGAGTCCCAGGTTCAT +CTTTCGAGCTGTTTCCTGAGAAATTGTACAGGATTTGTCTGAGTCGTGAA +CTGAACACGCTTTTCAGGTAAACGTCGTCTGGATGTCCTGGAAATCAAAT +GTTAGTCTTTGTATCGATGGAAAACATGGTTTTCTCAAGGAAATAGTCGG +AAAGTCGGTCGATGCACCATGTTGTGGCACCACGGAGTGGCGGAAGACCG +AACCCTTTAAGCCTCAAGAGGAACCGAGCAACGAAGACTATGTCAGAGGT +GCAGCATGGCATCGTCTATTTGTATATGTATTGGAAAGAACAGAACACAG +TTTTAATAAATATGTTTATTACTCCAAAGGGGAGATAATCAACAGAGGGG +AGTGGGTCGTACACAAGAGAGAGGGAATTGTCTGGTGTGAGAATATCACG +TCCTGCCACGCGGGTCTTTAGTCTGAAAAGGTCGAGTGTATGAATAGTCG +GGGTCTTTGCAGACTCGTAGAATAATGTCTTTGGTCAACTACACTTTCCA +AATAAAGGGAGGGAAAGGTAGGAAACGTCGGCAATTAGTCTGACTGGGAG +CTGTCAATAACGGGGGGGGGGGGGGGGGGGGAAGAGACCAGCAAAACCGA +ACCAAGAGTGGGGAGGAGAGTTCCTTTCCTGGTGCCACCGACGCTGCAGC +TCGCTCCGTATCGTCGCTCATTGAGTCGCCGCGCAGCCAATCGTTGCTAC +GGGGCGCGAGTGTAACTCTCGTTAGAGAGCGTGTGGGAGCAAGAGACGCA +GAAATACAGTAAACTTCTCCTAACTGTATGGTAAGCTTAAGAGCTGGTCT +TAAAAGGTCGAATTGAATGTACCCCTCGCTCGGAGAACTGCTGAAGCAGT +CGAGAGCGAGACATTGTGAAATGGGCGATACAGCAGAGCCCAGTTCACAA +CAATCAGACTAACTGGCACTTACGTATAAATAATATTATGGGTTTCGTCG +CTCCCCCTCCAAATGTTTTAAAAACGATTTAAAACATAATTTATACTGTT +TTTTTTTACTACTGACCAATGAAAGTTCATGGTTGATAACATAAATCCCC +ACATTTTCAGAAAAATGGATAAGCAGAAAAAAAGTTATTAATGAACTCAT +AATTTTCATCGAAATTAGCCAGCTTTAGTTTCGGTGTATTACCAGAAAAC +AAATTTAAGTGATCTTACTCTCAACTCCAACAGAGTATCTAATTGATTAG +ACACATTTTTTACAATCTTGCTGACAATTGTGCGATTTTTGAAGATTTTG +TCAATAAGCACGTGATCCTGAAAATAAAAAAGTGAGTAATTTTACGCTCG +CGAAATTGTGAGCCAGTGGCTGCCTAGATTTTCAATTTGTTACATTATTT +TGCAGCCATACGTGGACCATAATTCTGGCGACCACTTTACGGCATTATAA +TTTTTTGAACTGCAAACAAAACATGTAAATATACATATATGTATACTAGG +AATTCGCACTAAAGTAAATTATTGAAATTCGTCAACTTTTATTTTCATTT +CTTATATTTTGTCTAATTTTCAACGAATTATTGAAAATGAAAATTTTTAA +TTCACGTCAAAATTAGTGAACGCGGTGAACGGCGACGGCGAAGGCGGGCC +GGCGTGAGGCCGGCGTGAGGCCCGCGTTTCGCGCCTCACTTAGCTGGAAA +CCCTAAGTTTCTCCAATTAAATTACAGGTGATATACATTTTTCCTCTTTA +GGATAAGAAAAGATCATTTCCTAAGCCTGACAATACAAAAATGTGGTTCA +CGTTTTTATTTTTCATAACTTAAAAAAATACTATTAAAATGAGGGCATGT +AATACACAAATACCGGCAAACGGTGTTTCAAATCAAATATTGAAGAAAAA +ACAAACAAAATATGATGAATTCTCTTTGTTCTTACCAAAATCGAAACCAT +CATTTAAAATTTAGCAATTTTTTACAGTTATATTTGGTAATTACGGCCCA +TTTTCTATAATATAAAGAAACAATTGAAACTGATCCACCCTGTCCGCCGA +CTATTGGGCATCGACAGATGGTGTTCTCAAAATACCAAAAATGGGTGGAA +CTCTCTCACGAGCGCTCTGCAGGTGTCGTTTTCCTTTGCAAAGGACTGCC +CTTCCATTCATTTGTGTCTCTATACAACATCTCATCTGTCATGCAAACCG +ACATTCCCAACATACTCGAAATCCCAATTGATGTAAGTTCTTGTTTCTTA +AACTAAAATTAGCCAACTATTTTCTAGAAATATCAATCTAGACCGAAATA +CCTTTTACTCTTGAATGATATCAAAAGTTTAAAAATGTTTTATCTGGTAA +ATATATTATTCAGTCAATAATAACAGAGCAATAATTTCCTATTTGTAAGA +CGGTTTGCCAGCCCTACTGATGTAAGCTAAAGGTCCTACAAAAAATCCCT +GAATTTTGGGTCTCCTTTGCTAACTACAAATGGTAGGCAAAAGAACATAT +TTGTGTACAAAAAAGTATGCAAGCAAAAGAGACAGCGTAGGCAGGCAAAA +GATTCATAAAAGAGAGATAGCCCCCGCGGTCAAATCATTCTACTAGTGGC +TTGAAGCCTCTGTTGATGTGATAAAAGTAACATTTTATATAGCATTGTGT +TCGATTTTTCTAACAAATAAAATGCATATCATTACTTATACAGTGCGTGC +ATGTTCTTTATGCCACCCCCAAAGTTTTTAATCATGGCAGTTTCTGTGTA +ATTTGGTGAGCAAAAAGTATTGAAAACCTATTCACAATGAAAAACCTAAA +CTCAAGAAATGTTGTGATTATATCTCGAAAATTGTGAAAAATAAGACAAT +AAATCAAAAATTGGCCGTGCAACTTCTATATGCCACCTCGGATTTTTTTA +TGATTTCTTATGATTTTAGACTATTAACTTATTATTCAAATAAAATTCGA +TTCAATTCGTATACATTTCAGTGCTAAATAACTATTCCTGTAACTTCTCC +CAAAGACGATACGATGATCAAAATATGGGGATATGTTCTAGATACTAATT +AAACATAGTATGTGAATATTGGTTCACATTGGTGGATTTTTAGCGTCGCC +AGAGGGACATATTTGGTGTCCCCAGCCGTTTTTGGTGAAAACACTATTTC +TCTTTTTTTTCTCGGTGCCAATCAAGTTGAGAAATTTCAGGCATGCTCTC +GAACCTTCAGGAAAGATCGAATACTGCAGAAAACCTGTAGACTAGGAAAA +CAACTTGGAAGTTTCTTAAAAGTTTGGAATTTTACTAGAATTTTCTGAAA +AATTTCAGAAAAAAAGAGACTTTCAAGAAACTTCTGAAAACTTCGAGAAA +GTTCTGGAATGTTCCAGATTTTTCTAAAAAGTAACAAATTCCGTTCAGAA +CAATGTTTTGAATATATGCCAGAATCTTACTCAAGTAAAATAATTTTTTT +TAAATTCTGATACTCCAAAAATATTATGAAATTTCAAAAAAAATTAAATT +TAATAGACGTTTGCAATACTATTGAAGACCTGAAAAAATGTTAGAAATTT +AGAAATTGTTCATTTTGAAGTATTCGAAATACTGTTCGATTATTCATGAG +ACTGATAATGTTATCAGTTTTTTTTATTTGAAAGCTTTCTAAGAATTTCA +TATGATTAGAACATCGAAATAGTTTTACTTTAAAGAAAAAATTGCTCCTG +GAAAATTTTAACTGCTGAAAACTTGGTTACAGAAATTTTATGATGCTCAA +ACACTTCCTGGAAACTGAAAAAAAAAAACGTTTCATCTGCAAAGAAAAAC +TTAGAACAAATTTCAATAATTTACTTTAGTGCAAATTCCTAGTATACATA +TATGTATATTTACATGTTTTGTTTGCAGTTCAAAAAATTATAATGCCGTA +AAATGGTCGCCAGAATTATGGTCCACGTATGGCTGCAAAATAATGTAAAA +AATTGAAAATCTAGGCAGCCACTGGCTCACAATTTCGCGAGCGTAAAATT +ACTCACTTTTTTATTTTCAGGATCACGTGCTTATTGACAAAATCTTCAAA +AATCGCACAATTGTCAGCAAGATTGTAAAAAATGTGTCTAATCAATTAAA +TACTCTGTTGGAGTTGAGAGTAAGATCACTTAAATTTGTTTTCTGGTAAT +ACACCGAAACTAAAGCTGGCTAATTTCGATGAAAATTATGAGTTCATTAA +TAACTTTTTTTCTGCTTATCCATTTTTCTGAAAATGTGGGGATTTATGTT +ATCAACCATGAACTTTCATTGGTCAGTAGTAAAAAAAACAGTATAAATTA +TGTTTTAAATCGTTTTTAAAACATTTGGAGGGGGAGCGACGAAACCCATA +ATATTATTTATACGTAAGTGCCAGTTAGTCTGATGGCATTGATGAACTTT +TATCAAAAAAAATTAATAAAAATTTGCCGCTGCAAATAAACAAAAACTTA +GTTTTTCAAACAAAAAAAATCAATACAGCGGACTGATATCCCTAATTATA +GACAGGTATCAAAATTGTGTTCAATTTTACTTTAATTCGCTCTTTTTTCA +GCTGATAAATAAATTGTTCAGCGAAGAAGTTTTGCACAAAATTCGAAATG +AGCATCGAAAAATACAAATTCACAGTTTCAAGACTTGTAAAAATTGAAGA +AAAAGATCAATATTCATTAACAATCAAGTAGATCCTGAACTTCCGCTAAA +ACAGCCTCGTCGATGCACTTGCTCGTTTCTTATAAATGCACTGGAGATAA +ACAAGAACAAGGTGAAACACTTATTCGTGTAAGTTGAAATCAATTGTTCA +AAACCTGGTTTTTTTGCTCGCCGCTTCCTCTGTTAACTACCAAAAAATTC +AATTTTATTTTGATGTTGATAGAATTTTGACCGGTAAGGGAAATATTTCA +ACTTAAACCCGGACTTTCGAATGACCACTCTAAAAAAGAGCTAGCGGCAG +AGGATCAATTTGAGCTAGGGAAAAGTCGATCTGAGAAGTGTTTCAGACAA +TTTTTCATCAAAATAGGTGGTTCAGAACTTGCCTTTAAAAAGTGTTTTCT +GAGTCTGTTGAAGTTTTTTATGCTTTTTTGTGATCGTGGAAACAATATGA +GAAGTGGTGAAAATTTCAATCAATTAAACCAATTTTTAATGTTTTGTACT +CAGCTGTAACATTATTTTCAGATTTTTAAAAAATACGGTAAATGTGAAAG +TCTACAAGCTTTATGTCGAACCGATTAAGAAAAACGAAATTTCGTGCGGA +GTGGATGCTCGAATTATACTCAATGATCTCATACACGATTGCTTGATTGG +AGTAGATTGTAAGTCAATTTTTGACATGAGCGCCTGTTTTTCAGAATTCT +GAGTAAAATATATGGCTTTTGAACTACTGATTTGACATTCATGATTTTTA +GATGGACTCGTTGAAGAATATAAAAATGATTTTTGCTGTGGTTGTCAAAT +ATGTCGAGACATTCATAGAAATAAAAACTGTATAGTTCATAGTATTCAAC +TTCAATATTTTGGTGGAAATTCGATACCGCAGCAGTTTTTGAATTTGATG +TTGGAAAATTTTGGAGTTGATGAGCATGATCGATTTATGGACAGATTAAA +CGAACTATTCGGGAAATTCGCATATCTTCGATTGAGCAATTTTGGAATTG +ATGAGTTGCGAATATCGGGAGAAGAGCTATTTGGAGAATTAAAAATAATA +GAAATCATAAATCAAATCAGGATATCTCCACATCATTACAAAGCGCTGGA +AATGAAAGACTGGTGAGTGTAAATTGATACATTTGTAATGAACACCGTCG +AACAGATGTTTGAATCACTGCTTTAGTTTTTCTATTATAACAGTACACGT +ATTGTAACAGGTTCTCAAAAGAGTGAATTCTCGTGTTTTTCATACTTAGA +TAGTCTCTCCATTCCTTCACTTAAAGTTATCCCAAAAACAAACAGCCCAC +TGCGATCAATGTCATGGAAACTTTATTCTCGTTTTTTTCGTTCTTCTGAG +AGGAAATCGGAAAATCGAATAATTGGATATTGAAAAACGGAAAATTTCGG +TGTTTCAATTTTCCGGAAAACCAAAAATCGGATTGTTTAGAAAATTAACA +AAAAAATCAAATTTTGTTTTTGTTGATGAAAAACTCAGACACTCTTGACA +TGATATGCTCAGGAACATTATAAAGATTACATTTTACAGGTTGTTTTATC +GGACCATATACGAAAAGCAACTAGGGCGGTACGTAGTTGGTGCTCGAGCA +AATTATTTCCTCAATTCATTGGTAACATGCCACACATTCACCGTTTTAAT +ACTGGGAAAAGAGTTCCTTTCAATCCCAAGAGACTTTTTATACCAGCTTA +TTTCAAAGTGGAATGTTAAGGATTTCAGACTGGAGTTCCGGTTCGAAGCT +TACAGTGGTCATTTTAATACTATGTTTAGTTCAAATATGGATTTCATTTT +GGAAACGTCTAAAGACTTTTCAAATGCCGTATTCAATGTACCATTCAACA +CCCAACCCGTTTCGAGGGTTCTTCTGGAAAAAGTGGAGATCGATTTACAA +TACTCTGAGGATATGTTACTCGAAATGAACGAACAACTGGAAAACGACTA +TTATTCACCAATGGACAATGTGATTGCAAATGTTCAACGAAACTTCCCAG +CCAAGAGTATGACTGTTCTACTTCCTAAAACGTATCTCCTCATTACTCCG +GACAATATGGACAGAGTCACAGCAAAGCTAATCCGATTGACTGAACAAAA +CAGCCAGAGAAATGGAAGTGTCACATTCAACTTATACTATCAGCATGACA +AAGGAGAAAAACATATTCCAGAGGATATCCCAGACATTTTCAATTCAAGA +GCACGTCTTGTAGGTGAAAAACCAGTAGATTGTTGGTATCTCGATGATAT +TTTAAATATCCCCAAAGAAAATTTCAAGGATGGATTTGGAGAAGTGACTG +TCTGGTATGGAAAAAGCTTTCAAATAAGAAATTCCACAGAAAATCGAAGA +ATGAATTTTAATATATTCTATACCAAAAGCTATCTGAAAAAGTTCTTCAA +TGAGAGACATAGTAGATGGGTGAAAACTGGATTTTTATTGCATTTCATGG +ATCTTATTAATTGATTTTATGTGTATTTCTGTTACTACTAATAAAGCAAA +TACTCTGTCCGTCCAAACCATGTAGCCTGTAGACCTCGGACAAGAGTTGG +GCGCTGCCTAAAAAATGAAAAAAGTCGTCAACTACCTCGTCGTCTCGAGG +CGTCGCCGAAGTCTTACCTGCTGAGCCATGATGGTCGCGCGGAAAGATGC +ACACTAGTAATAACATATCGTACTCATATTCTGATAGTTTTTTTTGGGGA +AGTGTCAGACGTATCTGATTGATACGGTATTCTCACATACCTTATTTCAT +TCGTTTTCAAGTGTGCTCACTAAGGATTCTAATAGTAAGTTCAGAATTTA +CAGAATTACTGTAATTCAAGTTTGTTTCATGTCTTTCAATAACAGACAAT +TTTATAAAATTTTGCATTTCAAAGGAACAGTTCAGTCTTAGAAAAATTCA +AAATTTGATCCATGGGATTGACTGACTATTGTTTGTATACCAGCCGTTCG +CACAATGCGAGTGCTCCGACTGGCGTACTCGAAATTAAGATGAAATTCTA +AAATTTCTAAGCCTTGGAACGTTTTTCTCAGTCTTCCAGAAGTTTTTAAA +GCAACATGAATATTATATAACTAAGTTTTCAAAAGTTACAGATGTTTTCG +GCCGAAATTAGACTATTTTGCAATATTTTGCGACTTTTTGCTGAAAAATG +GTACCCATCAGAGATGTGCGGCATGTGCCGAACGGCATGTGCCGATGTGC +CGAAAATTATTCCACTCGGCACATCGGCATGTGCCGACCTTTTTTGTCGG +CACATTTCGGCACATTTCGGCATATTCGGCACTGTCTGGAATATGTACCA +AAATTTATTTTTTAATTTTAAAAATGCAAAGAAACTTCAAAAAATTGATT +AAAATTTTCGGAATTTATCATTTCAACTTATAGTTTACTAACTTCAATAT +TAAGACAAATGCACTGCATTTTTTATGGGGTTATCCAACTGAATGTTCCC +GCTTTTTCCTCCTGTTTCCCCCCTCTAGTCGCGATCCAACTGGGAGGAAA +AATGCATTTTCCCCTCGTTTTCGCATTTTTTAGCTGCGAAATTTCAGAAC +TGAGCTTAGGGTGGGCATTTATAGACTTTTTTTAATTTTTTTTGACCAGA +AAAAGTTAAATTTTTATAGTTATTTTACCAATTGGACCTTAAATTTGAGC +TATGATATCTTTGTGGTAAGCCAGAGTCATGGTGAGTGATCAACTACAGA +GTTGTAGCAAATTTTCTGTTTAAAATTTTGTTAGTTGATCAATTCTTGGT +ATCATAGATTTTCACAGACTAACATAGCTGTGAAACTGGACAATTTCTTA +ATGTAAATTGCGTACACGAGATTTCTCTATTTTCCGCGTGGAGTACTAAT +ACCAAAAATTGATCAACTAACAAAATTTTAAACAGAAACCTTGCTACAAC +TCTGTAGTTGATCACTTACCATGACTGTGGCTCACCACAAAGATATCATA +GCTCAAAGTTAAGGTCCAATTCATTTTAAAAAAAACTATAAAAATTTAAC +TATTTCTGGTCAAAGAAAGCTGGAACCGCATTAAAAATTATGTTATTTTA +GTATTTCAACAAATGTCTAACTGTGAAAATTAAAAGTAAGTTTGAAAAAA +TTTCTTTAAAACATTTTTTGATAATTTTTTCATGTCCTGTGCAGATTTCA +AATTTTGAAACAATACTTTTAATTCTCATATATCTCCGTTGAAAAATTTT +TTATGACAAAGTGATCAATTACAAAGTTGTACTTTGGATTAAGAAAAAAA +AACTTTGTAGTTGATCACTTTGTCATATAAATTTTTTCCACGGAGATATA +CGCATCCGAAGTGAATGAGTTTTCACTATCAATTCTACTAAACCCTATGT +TTTTGTCTGAAATCGTGTTCAGAACATCCAAACTGAAAAAAACAACAAAC +ATTGCAAGTAATTTTTTGTTATTTATTTAAATTGATGAACTTTTTGTTTT +TTTTAAGAAGCTATATAGTATCTTTGCAAATGTGCCGAATGTGCCGATTT +TTTTAGGTTCGGCATGTACCGAGTGCCGAGAAAAAATTAATTCGGCACAT +CGGCATGTGCCGATGTGCCGAAATTTCAACAAGTGCCGCACATCTCTGGT +ACCCATCGTCTCGTCACGACAAATTTTTGTTAAATTCGAGTATGTGTGCG +CCTTTAAAGAGTACTGTAATTTGAAACTTTCGTTCCTATGGAATTTTCTT +TGACTTTTCACTTTTTCCTCTGGTTTTTATCCAATATTCATAGAAAAAAA +GAGAAAATTTTTCTAAAAATCGAAAGTTTGAAGTTACAGTACTCCTTAAA +GGCGCATAACGTTTCGGAATAAACAAAAATTTGTCGTGGCGAGACCTGAG +TATTATTACAGGAACGCAAAATTCGGAGAATGCGTTTTACACAACATATT +TGACGCGCAAAATATCTCGTAGCGAAAACTACAGTCATTTTTTAAATGAC +TACTGTAGCACTGGTGTCGATTTACGGGCTAGATTTTTATTAATTTCTGA +AAATTGAGCACCCGTAAATCGACACTACTGTAGTTATTTGAACAGGATTA +CTGTAGTTTTTCGCTACGAGATAATTTGCGCGTCAGATATTTTGTGCAAT +ACGCATTATAAGGGACAAGTTCTCCAGTGAATTCTTCCAATTACATTGAA +ATCCTTCTATTTTGAATACAAATTACTCAAAAGACAAAGTGTCGATTTAG +CCTAAACATTGCGCATGCGTAATTTCTGAATCTTGTTCGTTCTTTACATC +TGCACACTTGGGTAAGAAGTTGGGCAGCCTATGTTTTAGAGGGAAGTCAA +CAATGTTATTTTCGCACTTGTGGCAACAGAGTTGAAACTACGGTACTGTA +TATGGGTACACCTTTTAAAATTTTAAACAAAAATTTGTCTTGTTGAGACC +GGAGCACATAGATATTCTCAGTGTGTATTTGTCTAAAAACCTGCCAATAT +TTGAAAATCTTTCAAAACTTCAATATTTTGCTCCAAAAATTAAATTTTTC +AAATAATCTACAAAAAGAATCCAATTTGACTGAAAACCTGCTAATATTTA +AAAATCTTTCAAATGTATAATTTTTTTGCTCCAAAAACTGATTTTTTTCA +AATAATCACAATTTCAATTTTAATTTCGATAAAGATACACAAAAAAAAAG +AATAGCATTTAAGGATTTCCTTGTTAAGCTTCAACAGCGTAAGGGAAGGC +CTCGTTGGCAATCATCATGCGTGTAAGTTCGGCGGCGCTGAAAATAAATT +TTTGATGTTTAGCTTGCATGGTATGTATTACTGATCCCTCAACTCCGCCA +TGGTCCGACCCTGACGAAGTGGTATCTCTCCAGCATGGTGAACTCTGACG +TGATTCCAGTGCACAAGCCTTGTTGCAGTATACGACAGCCCACAGATACC +GCAGTAATACGGATAGGGAAGGGTATGCAGATGGTAGACGTGGCGAGCCC +TGAATGTTGAAACTGACTTTTTGAAATGACTGGAAAAATAATTACAAGTC +AACTTGCTGTCCGAAATTCATCATTACAAATGGAGCATTGGAATTGTTGA +GCATCAGGAGATTCCGAATTCCGATGGGTATCTTGAGGCTCTTCCATTTC +CTGAAAATTGTAATTTTAGACTTTTTAGATAATATTCACAAAATCTGTTT +AGGAAAAATTAACTACTAAAGTTACAGTAAGAATTTTGCTCTGAATTTGC +TCATAAAGGAAATTTTTTTAAGCTTGCACCCTGATTTGTTTAAATTCTTC +AATCTTTGGATTCCTCGCAAAAAATTCAATTCAGTCTCCTGGGCGTCGAA +TTGCGATGGAGCGCGCTTGCCGTGCGTTGGCGCAGCCACGGTGGTTCAGT +TGTAAGATGGGTGCAAACGCGCTCCACAGAGTTTTCGATCCCCAGGAGAC +TGTGTCCAAGTAAACTGAGTGGTAGCTTTTTTGTTCAAAAAATGTGCCCC +GCCCATTGGAAAAGCATGACCTTGTAATCGAAAATCCTTCAAATACGATT +TCTATTCAAATTTACGAAACTGAAAAAAAATTAATTTTACGAACACTTTG +ACGTCCATTCGGTGAGATTCTTTCAGGTGTGAATCGTTTTCTCTTGTTAC +GAGCATCATTTGGCTCCGGCACCGCCATCTGACCGGCCTAAAATAAGAAT +GTTTAAAAAAATATGCATTTAGGAAGTTTAATATTCAAAACAGAAGAGAC +ACATTCCATATGAAAACAACTTACATTCTGAACGTTTCCAACGTCCGCCG +ATTCCTTTACACCGTATCGATCGATTAAAAAATCGATCAGCTGACCGTTG +AGCAGTACATCCTGGAGCGAGATGGTGATCGGAGCCACCGGTGGTGCAGT +CTCATCGTCTGAAGATCCAGATCCGAAGGCATAGCTGTCCGAGTGGATGG +TGTTGGAGTGGTCGAATTTCTGAAAATTGACCAATTTTTGATTTTTTAGA +CTTGAAAAGGCCTAAAAAGGACAAAACGAGCCCCAAAAATTTGAACAAAA +GGGTTGAAATTTCATATTTTGTTAATTTTTCTGTGTCACAATTTTGATTT +TCAATCTATCGATATTTTGAATAAATTTCAATTTTTTCGGGAAAATATTG +CAAAATTTAGTCATTTTTCCTCAAAATAAACCAAAATTTGATTTTAAAAG +TTTGGAGAATGAATTGTTGAACTTGGAAACACCAAAATTAGCTCTAAAAT +TTCGAAAAAATGGGTAATTTCAACTTTCCGTATCTTTTCAGTTTGTCGGA +ATTTTTAAAAAATTTTATTACAGAAAACCACCAATAATTAAAATCTTGAC +TTTTTTTTTAACCCTAAAAGATTTTTTTCGAGAAAATATCTTAAAATTTA +GTCATTTTTCTTCTTTTTAGGAGCTATTTTTATGTTTTTTACTTTTTGTT +CCGTCAAAAACAATTTTAATTGTAAAGGTTTTTTTACGATTTTTCCAGAA +AAACCGGTAAATGACACTATTACGGGAACAAAAAATTTGGAAAATGCGTA +CTGCACAACATATCTGACGCACAAAATATCTTGTAGCGAAAACTACAGTA +ATCCTTTTCAAATGGCTACTGTAGTGTCGAATTACGGGGCTCGATGTTCA +GAAATTAATTTTTTAATCGAGCCCCGTAAATCGACACTACAGTAGCCATT +TGAAAAGTATTACTGTAGTTTTCGCTACGAGACCCTATTTTGCGCGTCGA +ATATGTTGTACAGTACGCATTTTCAGAATTTTGTGTTCCTGTAATAATAC +TAAGATCTCGCCACGACAAAGCGAAAAATTTTTATCGATTTTTCAGCAAT +TTTTCTCTTGTTTTCATAAAAATTGGGCAAAAACCGGAGGAAAAAAGTGA +CGAATTAATAAAAATTCCATGGCAACGAAAGTTTGAAGCTACAGTACTCT +TTAAAGAAGTGCACCTTTTTGGATTAACAAAATTTTGTCGTGACGAGACC +CTGGATACCATTTTTCCGGCGGAAAAGTCGCAAAATTAGCGATTTTGGGA +ATTTTTCGCGGCGAGACAACTGCACAACTCGACATGCGAGTTTATCCTTG +CAGATGGCCAAAAGCCCTCCGTCGATCATTTGACGAAGCAATTCCCTGGT +GTTGCGAGCTCGACGAGCTTCTGAACGATGAAATTGCCATTTCGACTGTG +GCAGAGCCCCACGAAGAGCGTCGTGGATTTGGTGAGCTTCTCGAACACGG +CTTTACGAATCTGATCTTCGGAATTTAGTGGATAGTTGGCCTCCAAGAAC +CTTACCCCCGATGGATAGATTGCGAAATCGATGAGCTGCCCGTTGAGCAG +CACATCTTCGAGCGAAATGAAAATCGGAGCCACTGGTGGTGGGGTCTCAT +CGTCGGATGATCCCGATCCACTGTTGAGGATAAAGCTGTCCGAGTCGGAG +GAGGTGGTGTTGCTTCCGTGGCGGTAGGGGAGAAGCTTGACCGGCGGCTT +TGGATTCTGGAAATTCGAATTTTAAACTTTTATTATATTTTTATTTAAAT +TAGAAATTTTTATGCAATATTTTACCTTGTTCTTGTGAGTTTTTTTCGAC +AAAAGCGAGAAATCCGGGTCGAAATCGAACGACGCGCCGAGCATGTTGTA +CGAATCCGTGCTTTTACGATTCGGAGTCATTTAGACAGAAAAATGAATGA +ATATAGGTTAGTAGACGCTGAAAAATTGGGAATTTTGGATTTTTTAACGG +AAAAACGAGTGAAAATGAGAGAAAAACATGTAAATTTCAACGAAAATCGC +GAAATTACCGCGCATCGAAATTCAAAATTGAATTTTTCGCGGTGGCCCGG +GTTACGGTGATTTTTAAAGGCGCATGGTTGTTTTGAGTGAGGTATTGACG +CGAAATTTAAAATTATTGAATATTTTTTTCTTATTTTTACATTTTTGAAG +AAAAAAATGATTAAAATTCGATTTTTTAGGGAAAATTAAACATTTTCACA +AAAATTGCAGGAAATCACTCGCCAAAATTCAAAAATGAAGAGTTTCGTGG +TGCGCCGGGTTACGGTGGATTTTAAAGGCGCATGGCTGTTTTGTATTAGG +TCTCACCACGAAACTTGGAGTTTTTGATAGTTTACTTCCTATTAGGGATT +TATTTTTTTAATTTTCGCTCGATTTTCACACATTTTCACTCATATTCACT +CAATTTTTTGCAGAAAAAATGTCAATGGACATTGTTATGAAGTCAGATGA +GCAGCCGTTCATCTCTGCGCCTGTATGCTTTAAGTAAGCTCCAATTTTTG +TTATTCTGGCCTAAAATTATTTTTTTGATTTCCAGAACGTTCGCATTTTT +CGCCAAAGCATCCGCAGAGGAATGCAAACTTCTAGCTTCGGGCTCCAACG +CTCGAGAAAGTTTCCAGCAGGCCACGGGGCTATCGGAGAAGATCACGGAA +GACATTTACCGCCAAATTGAGTAGGTTTTTCGATTTTTTTACCCTTAAAA +ACTACTATTTTTCTATTTTCCAGCGTCTCCCACATTTCATCGATGGTCTT +CAACAGAGAAATGGACGGTGGCATCGAGAGAAATCGGCTCGGCTCGCAAG +CGATTCTGCTCGACGAGAACTCCAGGCGCCGCAATCCACAGTTCAAATCG +ATCGCGCTCCGCTCTCTCCGCTACGATCACATCGATCATAGAGCGTTGGC +AAGGAAATCGCCTCATCTGATGCCTCCGACTTATATCAAAGAGGAAATTA +TGGATGATGAGCTCGACGAGGTGAAGGAAGAAGTGGTTTCCGTTGGAGAA +GCCGCCTTGCCCACGCCAAAAGTTGAACTGAACATGGACCATCCGGAAAA +GGACCTGATCATCAGCATTTCCGTGTATCTCGGCTACACCCGTACCCTTC +AATACCACGAGATTCGTCTCGGACGTTTGATGAAGGTCACGGATCGGCTC +GAGCTCACCGGAGATCACACGCTTCGCGATCTGAAAAACGCGTTCTCGTG +CCCCATCGATTTCTCGTTTTCCGACGATTTTAGCGAGAAAAAGCCGTCGT +TCAAGGATATGGCGAAAAATAAGTGGCCGTCGTCGATGTTCTTCATTCAT +GACACGTTTTATATCGACTCGAACACTGGCGACAAGTTTGTGGATCCGTC +GATGTGAGCAAGGGTGCCGGCTAAAAGTTTTTCAGTGTTTTTTGAGCGAA +AAGGAACAATTTTTTTCTGAAAATTATTGATTTTTCGTTAGTCTTCAGAA +AAAATGATTTTTTACGCCGCAAAATCGGGAAAAAACAAAAGAAAACTGAA +AATTAAGACATTTTCGTTGATAAAAACGAATTTTTTGGTTTTTTTTTTCA +GAAATATATTATTTTTTGCTTTATTTCAACAAAAAAAACCCAAATTTTCA +GCACAATCCGAAGTTGGGCCAAAAAGTTCGACTACATCGGTCCGATGCAC +GTGAAACAGATGTCGGAGACGAGGATCGGGGATCTCATTTGTCGGCTCGG +TCAGCCATACGTCTACATTCATCAAGGCGTCTGCGAGCACCTCATCGTCT +TCAATGACTTGTGCCTGAGGTACGGAAATTCTGGAAAAATCGAAAATTTT +GATTTAAAAAAACTCAAATATTTATGTGTTCTTTTTTTTACTAAAAATTT +TTTTCAAATTGTTTATGAAAAAAACACTAAAAAATAAGTTTTTATCAATT +ATTTAAACAAAATTTATATTTTCCGATTATCAAAATTGTTTTTTTTTTTC +AAATAAAATACCCCGAAAAATATATATTTTTTAATTTTTTTTTTCTATTT +TTTGCAGAGATGAATCCCACACAAACGTCGAATTTCCACGCCGCCTCGTC +GAACGGAATTTCAGAAGAATTGCATGTGACACGTGCAAGGAGGCGTCGGC +GCAGTGAGTAGTAGCATTTAGAAATTCGGAATTTTTTGTGAAACCCCCGA +AAAATATAGTTTTTATCGGAGTTCGAATTTTCGAAAAAAAAATCCAAAGA +GAATCGATTAAGGCAAAAATCATCAATTGAATCCAATTTTTTCAGCTGGA +TGATCGTCGACCACGACAATCTGCTTCCCAACTCGCCAGGCTATCTGTGC +TCTTCGTGCTACAAGGAGTTCTGTTTCGACGTGAACGGCAAAAAAGTGTG +CCAGTTTAAGGCCGTACCGTATTGCGATCGAAAGGACATTGGCGACGGAC +GCCAGTTCTTCACCGAGCTCGATCTTTAGAGAACGAGATTTAAAAGTCTG +TATCATTTTTTGTTGTTTTTTTTTAAATGTTTTTCGATTTGATTGTTTAA +TTACCGATTTTTGGCCTGTAACTATATTTGTTGAAATTTCAAATTTCTTT +TTTTTTAAATAAAATTTTTGTTTGCAAAAAAATTTATCCAATAAATAAAC +GGAATATATCGATGATATGGCAAGTAGGGGGAAACGGACGGGAAAATGAT +TATTTACAGAAAGGGCGCGCACCAGAGGTTTCTCGGGGGAGCCCCGAGGC +GGGTGGCGGAGCTTGGCTCAAAATCTGTCGGAAAAATGGGTTAAATGAGA +GAAGAGGTAACCTAGAAAATGAGATGAGAAATTCGGAAGAATTTTGAACA +ATTTGAAAAATCGATAATGTTGAATTTTAAAATTAAATTTTATTGATTTT +TTGAAAATCGATTATATTGTTGATTATTGATTAAAAATCACTAGAATCAA +TAAATCTGATTTGGAAAAATCAAAAAAATCGATTTTTTATAATCATAAAA +ATCAATTTTTAAAATCCAAAAAAATCGATATTTAAGAAATTGAAAAAAAA +TCGATAAATCAATACATAGGTGAGCTCGTCTCGTCGATTTGTGTTTTTGT +GATTGGTCCCGGCTGCTTTTGAGATGGTCTAGGCGTTGTTCCGTATGACA +TTCTGGAAATTTTTTTGTGAGGCAATGACACGCCCACAAAATGGACGGTG +GCAGAAATTTAATAATTTTAAATAATTTTCTGGATAAAAAAATCGATTTT +TCCACTTTTTCGAGTGAATCGAAAATTTAAAAAAAACATTCAAAATTGTT +CAGGGTCTCGCCACGAAAAACTCACAAATGCACGTTATGCGGAGCGTCGT +CGGATTCCGGTGTGTTGCTACGGATCGTGTCGTCCATGCTCAGCTTCATC +GTCGATTGACGTCGCCGTTTTGTGGTGATCTGAGCGAGATTTATTGATTT +TTAAAGACGCATGGCCTAGAAAACACAACACTTCGGCCACGGACTTTGGC +GGCCGAGTTTTCTAGGCCATGCTGCGGCATTTAAAGGCACATACCATGAT +AATGAAGATCGCCAATCCGAAAATGATGACCAATGCGAAAGTGATGATTA +CAATCATCAGCGATGATAAGGAATATGATGAAGTTTGCGTGGAAATAGAA +TCGATGTACGCTTGTGACGTCATTCCTGGAAATTATTGATTTTTTTGGAA +AAAATCAATAATTACTTACCGTCAACAGTAACACTCAACGAATCAATCTT +GTAATCCGAAATCATAGAGTTATTGCGTGAAAATGCGGCTTCGAACCTGA +AATGTTAAAAAAATCAATTATCGATTTTTTTGAAAGTTTTTGAAAGTTTT +TGAAAAATTGATACAATTAACTTGATATTCCCCCGGAAAACCTATAAATC +AATGAAAAAGTTAATATCTAAATTTTTTCCAAAAATTGAACTAAAGTCGA +TTATCGATTATCGATTTTACTAATCATTTTTCAAAAATCTATCATATAGA +CGATTCCTACGGAAACCCCGAACAAATCAAAAATCGATAAAATTGACTAT +CGATATTTTTTTCTAAATTTTACTTTTTTCGATAAAAGTCGATAGCGTTG +ATAATCGATTTTTTAGAGTTTTCCTCAAAAAATGGTAATAAAATATTTCT +AATCGGTAAGAACTCACAAATTAACAGCCATTTGAGCATCACCAAGTGAT +TTTTTGGTGAGCACGTCGGCTCCGACAACCACTGATCCTTTGGTCAGTGA +CTTGATTTCAACATTCACAAAATTGTCGTCTCCCGAAATGGAATTGATGA +ATTCTCCGATCTGGAAAAAAATCAATAATTGTTTAAAATTGATTTTTTTC +AGATCATTTTTAAAATAACTAGTCTAAATCTATATTGAAGTCTAACTCAA +AATTTTCCACAAAGGCTTACTATTAGGCTTAGGCTTAGGCTTAGGCTTAA +GCTCAGGCTTAGGCTTAGGCCACGCGAGATGAAAACAAAAGAGAAAATTT +AGTGAAAACAAGAAAAATTTCTTTTAAAAAAAAGAAAAAAAAAAAAAAAA +AAGAGCAACAGCCATGCAATTCTTAAATATAACAGGTTCAACTACTATCT +TCAAAAATCAGTTTAATATCGATTTTTCCCAAATGTCAATAATCCATTAT +CCATTTTTGACTCACCGCTGGCACCAAATCTTTCGCTAATCTCTTCGCAG +GGCCACTCTGAATATCGTTGAATTCCTCTACAAATTCCAGTGAAATAATA +CGAAAAACTATTGGTGTTCGAATGGATTTAGCCGGAAGGAATACTTTCGA +TGAGTTTTGAAGTGCCACCGGCACAGTTGAAATATCTTCAAAAGTCGTGG +ATTCCTCTGATGAGGTGGAGGTGGTCTCTTCGGAGGAGGTAGTGACGTCA +GTGGAGAGGGTTGATGGCTCGGTTTCGGCCATGGTTGTGTCCATTGTGGT +TTCCATAGTTTTTGTAGTTTCCATTGTTGAAGAGGATTTCATTCTGAAAA +TTTTGAAGTTTTGAATTTTTTCCTGCAATATATGAACACTTCCGAACCAG +CAAAACTCACTAGGTAGTGTTTTAACTATACGGTGCGATCGAGTAAAAGT +GTCATGCGATAGCTGGCATCTTAGGCTTTCAGAATCTGTAATTTGTTCCG +GCGGAAGACCTCTGTGAGTCTGGAAATTTTCATCTGAAAATTTAGTACTG +AAATCTGCATTTCCTATGGTTAACAGTGGATTTTTGTCTCTGGCGCCAAC +AGAAGTCTCACCACAATGGTGGAAGGGCGAAAACATCGCTTCGAAGCTGT +TAACCATAGGAAATGCACTGATTTCAGTACTAAATTTTCAGATGAAAATT +TCCAGACTCACAGAGGTCTTCCGCCGGAACAAATTACAGATTCTGAAAGC +CTAAGATGCCAGCTATCGCATGACACGTTTACTTTTACTCGATCGCACCG +TATAGTTAAAACACTCCCTAGTCAGATATGTGCTCTACACTTTTAAATTT +TGCAATCAAAATACTTGAATATAAAATTAAGAGATTTTTGAATTTACTAG +GCCACCTCGAAAATTTCTAGGCCACGGCAGGTTGGTAGGGTGAAGCTGCA +GACCCCATAAAGCTGTGAGAACGGTTTTTTTGCAAATTTTTTAAAACAAA +CATTTGTGAAGAATCTGAATATTATCAGAACAAAAAATAATTTCGACAAA +AAATAATAAATTTTTTTATCAATATTCAAAATTTTTAACTTCCGAAAAAA +CTCAAAAAAAAACTCACCCAGTCGTAGTGCTCTCGACCATCTGCTTCGTA +GTTTTCGGGATATTCGACAAAATCTTTGGCTCTTCCTCAGACATTTTCAG +AATTGGGAATGCGGGGCTCTGATCTGTGCTCAATGAGCTATCAATAACAC +TTCCATCCTGCTCAAAAAGTCCTTCCAGTGCACTTTGATCAAATGGTGTT +TCTCCGTCATCTCCAGCTTCTGATGGGTCACTTACTGCGACGGTGGATTG +GGTTGTGGTCACTGTAAAATTGGAAATTTGGAAGAGAAAAACCTCGGCCA +TTGGTGACGTCATACTTTTCGCCACTTCTTCGACCAGCTATAATGCCACG +CTTTTAGCAAGTTTTATTTTTGGTAAACCAAAGAGCAACCAATTTTAAAA +CTGTGTCTCCAGGTTTACCGCCAACTTAAGGGCGTGTCCGTACAGGGTTT +GCCCGTTTTATGGGCGTCGCTTAATAAATCATTTTTCAAGTTTTCAGTTT +CGTGGAAAATTAGCATCCGGGAAATTGAGTCATAAGTATGACGTCAGCAG +CCGCGCGGCTTCCCATGACGTCACTCCATGCGCTCCCCCGACGTCCCTCT +AAGACGTCACCACCTCTCACCTGGTTTAGTGGGTCGTGTCATCTCCTTCT +CTTTCAAAACTCGTCTATCAGCGACCTCGTCAACCTCAATCGGAAGGGAG +CTGAACGTAATCACCTCCAAGGGAGTGGTTGGCATCATTTCAGTCGTATT +TTCAGCGGCGAGAGTTGTTTTCTCAGTGGATTCATCCTGATCCTCCATAC +TATCATCTTCGATTGTTGCCTGGGAGAAGTTGAACATACCGCCGTCAAGC +GGAGTTATTGGGGAGAAGACGGACGTTTTCTGGATTGGGTTCACTTCTAG +GGAGGTGTCGTTCGGCGAGAGTTCGATCATTTCTGTACTTGTCTCGAAGG +TATCTGATCTGAAAGTTATGACATTTTTTTGGTGGTGGCCTGGGAGAAAA +CTAGGCCTCCTGGCCTAGAAATCTCAAACCTCGGCCTCCAGCTCTCACTA +GCTGACCTAGGTTTACTAAACATCGGCAAGACCTCTTTTCGACTACTCCC +TTACAAATTTTTAACAGTTTTTCATCACACAATTTTCCGATTCTTACCCC +TCATTCATCATTTCTTCTTTCGGAACAGCCATCATCGGCATATCATCATT +ATCAGGCATTACGGGTGTCGTTGTGTCTTTTGCCAGCGGTTTGTCGAACA +CATCTTCAGAATTTTCGTCTTGCGCGAAGGAAACTGAAAAAGTTAAATTA +CATTTTTTCTAGGCCACCAGGTTTTGCATTTTGGCCTAGAAAATGAAATG +AGAAGCTAGACCATGTGGGTTTATTGCGAGGAAAAGCTATCCCACGAAAA +CTTTTATAAGCGTCTAGAAAAGTAGAAACCTCGGCCACCAAGTTTTGCAC +TGTGACCTAAACAATTTTGGTAAAATAGGCCAGCAAAATTTCCATGATGG +CCTCAGGAAAACTAGGCCATTAAGGTTTCTTCCGTTACCTAGAAATTTTG +TAAACCTAGGTCACCAGGGTTTCTAGGCCACACAAGAAAAGCTAAAAACC +AACATTTCAGATCGGTCTGGAAAAGTGCAAAATTAAGCCACCAGGATTTG +CATGGTGGTAAAAAATTGGTAAACGTGAACTAGAAGTTTATCGGTCATCA +ACTTACGTGTCGTTGAAAATGCAATGAATAGAATAAAACCAAATGGTATG +CGCATCGCTGAAAAATTGCAAAAATTAATTTATGTTTTGGAAAATCAGAA +ATCGGAGTGTTCATTTTTTATGGGACAAGATAAAAAGAGATGGAGAAAAT +TTATATGATATATCAGGTCAAAATGACCTTCGGAAATTGGGAATGAAAAA +TCAAAATTAATTCGCGTGGAACTGGTTAAGATGATCGAAGATTGAAAAAT +TTGACAGAAATTGCAACAATACTAATGCAAAAAGTTGGTAAAATATTTTT +TTCAGTTTTCAGAAAAATCGATAGCAAAAGTCTTTTTTTTTAAATAAAAA +TTTCTGAAATATTTTCGCTGCGAGACCTAAGGTGACAAATTGGATTAAAA +ATTTTATGTGCCCATTAAGAGTTTTTCTGGAAACTGAAGAGAAAGTCGAA +AAATTAATATACCCTACTTAAATTTAAAGGCGCACGGATGAATTTCCAGA +AAACTAAAAAAAAACATCACAAAATTTGATACTCCAAGTTTAAAGATGCA +TGGGTAATCTTTGAATGAGAATTTTGTTTTAAATTTTTGAACTGCCATTT +CAGATATTATGAGAACACAAAATTCTAATAATGCGTATTGCGCAACATAT +TTTGCGCTCAAAATATCTCGTAGCGAAAACTACAGTAATTCTTTAAATAA +CTACTGTAACGCTTGTGTCGATTTACGCGCATCAAAATGAATTAAGATCA +TACATTTACCGACAAAATATTAAAATTAGGCAAAAAATAATACGAATAAT +GCATTTCGTAAATCGAGCACGTAAATCGACACAAGCGCTACAGTAGTCAT +CAAGAAAAATTACTGTACTTCTCGTTACGAGATATTTTGCGCATAAAATA +TGCTGCGCATTACGCATTCTCAGAATTTTGTGCGCCCGTAATAACCATTT +GTTAAATGCTTAAAAAATTCAGATTTTATTGAAAAAAATTTTTGAGCAAA +ATTTTTCGAAAAATAAATTTCGGCAATAAAATATTATTTTTCCATCGAAA +AAGTATCGTATGGTGTGCTTGACATAATCTTGGTAAAAAGTGGCATATTT +TGAAAACAAAAGGGGTTACCCCCTTCCTTCAGCCCGCCCGCCCGGGAAGC +CTGGGCATGCGCGCAAGTGATTGTTTTGTCTGTTGTTGCTTATGTATATG +CTTATTATTTACACATTTGTGTGTGTGTGAGTGACTACACTGCACACCTC +TTGAAACGGATTATCCGGCCGTGGTCGAGGAGGGCCGCCGAATTATGCAC +ATTCCTATGCTATGTATTGTGAATACTTCATTTCAATAACTTTATATATA +TACAGTTAGCACATACGATTTTTGAAAATTGGGGTTGTGGAAGAGTTTTC +ACACAAGTGGCCTAAAGTTTTTGAGTTTACTTTAATACTTCTAAATCACG +TGGTGTCAGGCGGTCTCAATACAATTTGATCTACAAAAAATGCCGGCATT +TTTTCCCAGAAAAATTGTGACGTCCGCACGCTCTCAACCATAAAAAATCA +GATGAGATCTGCGTCTCAACTCCCGCATTTTTTGAAGATCAAAGCGAAAT +GGGACTTTCTGACTCCACGTGCTAAATGAAATGTACGTTAAAAAATTATC +TCTGGAAATTTGGAATTGCTCGGTGGAGCGCGTTTGCCGCTTAGTAGCTG +AACCGTGATAGCTGCGCCGTGAAGAGAAGGGAAAAGTAAGGAAGTTATCA +AAACCAACGACGCACTAATGAAAAGGAACACAAGAAAAAGTGAAAGTGTT +TTTTTTTGGGTTTTTGTGATTTAGTTCGTGTGTGATAAAAGTTCAAATGG +TTCGGCAGGACAATAGGAAGGAAACTGGAATTTTATATTTCATCTCTTGT +TAAATTTACTTTTGTAGGTGTATGATTAGGTAGTGTTAATAGAAATCGGG +ACTCGTGGCCTATCATTTTTTTGTGGCCGAGTAAAAAAATCTTCCACATT +CGTCAACCATACGTGTGAATTTAAAGGTAATCTATAGGATATGATATTGG +TAAACTTTCACAGAAATCCTAAAGCTAGGTTTTGAACTATGGAGCTTTGA +AGTTTCTAGGCCCCTTTGGGAAACATAGGCCACCAACCTGAGAAAGGTAA +GGGGAGGGCAGGGTACATAAAATACAACTTTTTCTCTGAAGTTTTTTTTA +ATTAAGCGAAAAAGCCGACATAAATGTTTCAGTCATGGCCTAACTTGACA +TTGGTGGCCGATTTTTTCGAAAAACTCTTCCACGATTTAGAACATGAACT +TGGCAAAACTTCAAACAAATCCTAGAGATAGTTTTTGAATTATGAAGCTT +TGAAACTTCTAGACACGTTGAAAAAGTTAGACCTCTTCCACTGTCATAAA +CTTATAAATTCACAATTCAAAAATTATAGATTTCTTTCATATGTAGAATT +AGCCCAATTTTTAAATCCATTGCACGGCTAGATTTGAAATCATAGCAATT +TGAAAATTCTAGGCCACGCAAAAGAAAATTCTAGTTCATGGGAGTTGAAA +GAGAGTCTCGGAAGCTAATTTTAAAAGCACAAGATAGAGGAAAACCAAAA +ATTTATAAATTCATAAAAATCCAGTTTTTTAGCAGCTATGTGAAAAGGAT +TAGAATTTCAACACGGCCACCACCGCCGGAGATACAATCATTTTGGGAAT +ATATGTCGTTTTCGCGTATTTCTCACCAAAAAAAGATTCAAATCTTTTAA +TACGAAAAAAAGTTGGAAAAGAATTAGAAAAATGCTGAGAAATTTTTTTT +ATGAAAGCTTAGGCTTACAATTAGGCTTAGGCTTAGGCTTAGTTATTTTT +TCAGTGTTTTCCAAGTGCAGAAAGGAAGAAACCGACGCTTCCTGACTTTC +TATCACACACTGAGGGGAATTTCACCCAACCCCCCCCCCCCCCTCACTTC +CCGCTACTACTTTTACTGTACACTTTCACCGAAAAGTTATTGTGTCATCA +CGTCATTCGCCAAAAACGAATCGAACAAGGAGAAAAAATTGATGAGAAAA +CGCAAGTGTTTCTTCCTACACTACATAGTGTTCAACACCCCTTCATGATA +TGGCCGCGTGAAAACTCTTCCACGACCATAAAAGAAATTTACGGAACAAT +CTAGCAAATTTTCATAAAAATCGGTTGGAAACTATAAAAGTTACAGGGGT +TTGAATTTTCTAGGTCATGCGGAAAAAAACTCGGCCACGCAGGTTTTTAG +GGTTAGGGAGGCGGTGTCTTCAAAAAAAAAGAAACCTCGCACCTAATGAT +CCATGAATCTTCAAACAGAAAATGAGGTATAATCTTAGGTGGCCGAACTT +TTGTTTCTGAAGAAAACTCGGCCAAGACCACGAAAAACGTATTTTTTTGT +ATCGTTAATTGAAAAACTGAAAACAAGAAGTTTCTAGGCCATGTTGATAA +ACCTTCAGTAAAAATTTTTCCTAAGCCATTAAATTACTACTGAACTGAAA +ACCTAGGCCACGGCTTCAAAACATAGGCCACCAAAAACTGAAAGGGGGTC +GTAGGACCGGAACCTGCTATTATGAAGCAAAGTTTTGTGCAATAAAAGTT +TCAGAATTTCCAAGTTTTTAAACTATTTTTTGTCTGGAAATTATAAACCT +GAAATTTCGGGTGCGAGACAAGATGGTCAAAGAAAAATAACGAGAATTCG +GAGGGCAAAAAAATGAGAAGAATTTCCAGGAAAACAAGTGAAAGTGAGTA +TGACTTTGACCTATACGCGTATTGTCTTTTTTGTTTTCTTCTTCTCGAGA +AAAGAGAAACTGTCACAGCAGTAGTAGTTCTTCGATCACCTAATTACCTT +ATTGCCCCCTTCCAGGAAGTCACAGTTTTTTTTAGGAAATGTGTGAAAAA +TACACATTCCGCTAGGAAAAATTGAAATTGCGGTTATTGAGTTCCCTTGC +CACGACAACGTGGCCTAGGATACCGCCATGCTCTAGAAATCCCGCTTGTA +GCCTAGAATTTCCCATTGTGGCCTGGAGAAGTTTAGCGGGGCCTAAGACT +TTTAATTGTGATCTGAGAGTTTTTTCACATGGCCTAAAATGCTATACGTG +GTCTAAAATTCCTCATTGTTGAAATTTTTAGCGCGGCTTAGGATTTTCTA +TTATGGCACTGGATTCTCGCCGTGACCTAGAATTTCGTAATGTGGCCTGA +AAAGTTTAAGCGTGAAAAGTTTAAGTATTTTCAATCATAGCCTGGAGATT +TTTTACAAGAATTCCTCATTGTGGCCTTGAATTTTCTATTATGGCCTAGA +ATTTCGCATCGTGGCCTAGAAGAAATTTGCAGAGTGGTTTTGAAATTCGG +TTTGTGACCTAGGGTGCTATATTGTGGCCTAAATTCTTCCATCATAACGT +ATGATTTCACATTTTGACCTGAAAATTCTTTGCGTGGTCTAAGATTTCTC +ATTATATTCTCGAATTTAACTTCGACACGTGAGAACAATTTTGATGGCCT +AGAAATTGCTCCCGTGACCTAGGAAGTTTCAAATTTTTAAAGTTCAAATA +AATTTCACCAGAAATTCATCAAAATTTACAATTACGGAAAAAGAATCATA +TTAACCACTGCAACTTTTTTCGAACGAAGGACGAGGCAAAAAGGTTTCTA +GGCCATGGCCGAGTCCCCGACAAATTTCAGCGGCCATTTATTTTGCTTTG +TTTTTTGCGTGTTTTCTTTCGTTTTTCACCGATTTTTTCCGTTTTTTCTT +ATCAAAACTAATAAATAAATATTTTTTGCAGATGCTAAAACAATTTCCAA +GTGAAAAAATTGTGAATTCAGTCGGCAAGTAGCGGTAAAAGTGGTCAATG +TAATATGATGGATTACGGGAATAAAAAACCCAAACTTTTTCCCAAACATG +ATACATATGCTGTTTAGAAACACGGGAAAAATCGGTGAAAAACACAAGAA +AACAAAGCAAGTACAAAATGTCGTAAAATGCGGTGTATTGTGTGCAAACA +CCGATTTTTCGCATTTTTTCTCGGCCCTCGTTCGAAAAAAGTTGCAGTGT +TAACGGCGGTGGAAGAGCTTTACCTTTACAAAAGGTGGCCACAAAAAAAA +TAGAAGAAAGGATCCAAAAAGAGCAGGGAAGAGTTTTCTCAATTTGACGG +CCACGTGTTCTATAGAAAAAGATAAATACAATAAATACGTTTTTTGAACA +ATTAAAAAAACAAAAAATTTCAAGAAAAATTTAGAATATTTTTTCAGTTT +TTTTCCTGAAATTCAAATAGAATAAATGGAAGTTCAACAAAAAAAGGTGA +CCTAAATACTTATTAATTCACCTTCTTGACCTCTCGATTCTTCAGAAAAA +AGAATAGGCTTCTCCTCCTCCCACCTCCCAGACACTTATCTACACTTTAC +ATCATTCCTCCCGGCCCCCGGTTTTTTCACATTTTTCAACCTTGAAAATG +ACGAAATAAACAAGTGTTTTAGATAAATGTTTCTGTGTATGTTATCTGAA +ATCTTGGAAGGGTGTTGCAACAGAGCCCCGCGTGTAGCGTGGCCTAGAAA +TCCAAAAAGTCTTCTTTTAGATCTTCAGCTTTCTCAGCAAGTTAGGTCTT +AAGTCAAAAGGACTCTCCATGACCAAGTTATAACGATTTGTAGTTTCTAG +GCCATGGAGTACTCTCCGAAGGGGAGACATTGACCCCCTGACGCCGGATT +TGTAGGAATTTTCACGTGTTTATGCTACTGTAAGCGAGCTATATACGTTC +TTCAAAAATATCCGTCAAATTGTGACCACCGTTTCAGCACTTTAAAATTT +CTAGGCCACGCTGTCGCCATAATGGAATATTTTTCTCACGAGGAATAGAA +ATTAAAAAAAAAACTCTTCAACTGGTCGATATTTGGAAAACCAAACTAAA +ATGTTTCAGAATTATTAAAAGCTTAATTAAAACAAACAGCCACAAAAGTT +ACCTAAACTGATGAAATAAAGACATAGGCATACAGATTTATAAATCCTAT +AAGCATGGGTGTGTCACAGGTAAAGATTATGGAAAGTGAGGGAAAGTAGG +AAGATATTACTGGAAAGTTCTGGGGGAGAACGGCTGAAATCAAAATGGAT +TCGGTTGAACGCGTCGAATCACGGAGACTCGTTTGTAGGGCTTCCAGGTA +GATAAAAAATGTTCTGCCTGAATTGGGCCAAAACACATGAATCTTCAAAA +ACAAATTGACACAAGAAAATACATACTACTCCAAATTTTCAAAAATCAAA +AAATAGGCGATAGGTTTTTAGATACTAAAGTATATTGAGCAATTAAACAA +TTCACCCCCTACAACTGGCGGGCCCGCAGGGCCTGCTAGTCAGGCAAAAA +ATATATGGCCCACACTCCCAGCGACAAGAAAAATTAGGGGATATTAGAGA +CATTTACTCAAAAGGAGCATTACACAAATTTTAAAAATCTCAAAGCGGGA +AATTTTTTTAATGCGTACTGAATAAGAAATCGACGTTTAATGAAACTCAA +TTGCTACAACCCCGTAAACCTCCTTCACGTCCAATCAATAGTGACATGAA +TCCTTCCGACCAACGTCATAAAGATTGGAGATGACGAAATTTAAGATGTA +CCAAGTATGCTGGTACATACAATTTCTACGTCACAACATCTTGACAGTTT +TTTCCCTCAAAGAGAGGTGAGCCTGTAGAAGAGATACAAACGCTGCGTCC +TATCGTGGGTTCAGTTGTGGGGAAAAATTGTAAAAACTGTATGTACCAAC +TATGCTGATGTGCCAACTACCAACCAGCATAGTTGGTGCATCTTCAATTT +TGCCATCTCCAATCTTTATGACGTTGGTCGGAAGGACTTTTGTCACTATT +GATTGGAGGCTTACGGGGTTGAAACAATCGTTCATTAAAAGTCGTATTCT +TATTCAGTACGCATTTCAAAATGTTTCCCACTTTTTTTCGGCTTGATCTA +CGTAGATCTTTAAAAAATGCGGGAGAAGATATGCAGTGTTCTCAACTAAT +TTCGCATAGTTAAGAACGTGCTGACGTCACTTTTTTTTTGAGCAAAACAT +TCCGGCATTTTTTGTAGATCAATCCGTAATTGGACAGCCTGGCACCACGT +GTAAGAACACGATGCCTCTATTTTTGCCCGGGAGTGTGGGCCTTGAAAAG +TTGTGAGCTGTAGAAAAATGGACAACAAGCATGTTGTCAGTTAGCAGCAT +TTTATAAGTCAAGGACAAGTACAACCGAGATAAGTGAAAAGTTTGAAAAA +TGGAAAACTTTCAAAAAACAGCGAAGGTTCTTTGATCGATGCAAGGGCAG +AAAGTGAATAATGCATGTTTTTGAACTTAAAACAAATTGGCTAGACTTTG +ACTGAAACTACCTTTTATAAAAATGAAGAAAATGAACCATTACGAAAATG +TTAAATACACCTGAAAATTGGTGTGTTTTTATTGTCGTTCTGTAATTAAA +TTTTGAATGATCGCTCTTCTGCAAAGAACAACCACAAAAAATAATTCGAT +ATACTCAAGTATCGACACTTATGATTTGAATGCAAACATATAACAAATTA +AAATTAAAATACGGTCATTATATTTTAGGAAAATTATGGAAATTTTTTAG +GCTTATGATGTTTCAAAAACTTTCAGAACTCTAGTAAAAAACATTTTATA +TGTAATAAAACACTCAGCGACTTTAAACTTTGCAAGACAATTTGGGACAT +AATTTTGGGACATTGTAAGAACAGTTAATTGGAAAATAAAATAGTTATTC +GAATGATCGTTCTTCAAACAACCTTACAAACAACAACACACCTACTCTGC +TATAATAAGAAAATTTAAAATACTACTCAAGTTGTCACTTCAAGACCGCA +TAAGTTTATACCACTCGAACAAAAAACAGTCTTCGTTCTTTCTTTCTTGA +AAAGAGACATAATTGAAAATGAACTAATCAGCCGCTGCCCGGGATGGAAA +AAAGAAAAGAAATTCCTATCATCTTTTGACCTTGTTATTTTTGCAAATCA +TGTCTGAATAATACACTTTTTGATACATATAAATCAGGCGTGGGCGACAA +ACAATTTTTCCGGCAAATCGGCAAATTGCTGGAATTGAAATTTCCGGCAA +ATCGGCAAATCAAAAATGTTTGAAAATAGGAGAGTAAAAAGGTGGAAGTC +AAGTGATGGTAAGTACCTATTTTGTTTCAATCAAATTAAATTTTACACCA +TCTCTCTTTTTTTTCCTTATTTAACAGTCTTTGGTCTGTGTTCTGATGTT +GAAAGATAAGGGAACATGGACGAGTTGTTTTTGGGAAAAAACATTCTTTT +TGGATTATTTTAGTAAAAGAAAAATTTAAATTTATAAGCATATTCACTAA +ATATTTTTGTGGGAATTTGAAAAAAAAAGAAATTAAAGAAGAAACTGATA +AAAACTAGAAAATGTATAACTGGGAGAAAAAAGTTTCCAATTTTCAGAAC +TTTTGAAAAATTGTAGAAAATAGTTCATGCTTTCAAAGTTGTAGGAAAAA +ATAATATGTGGCCAATTTCCGAAAGAAAAAACTCTGCCACGACCAAAACT +CAGAACTAGACTGAAATTTCAGTTGTAGCTGACAAAACCATCCAAAAGAT +ATTGTAGGTTACAATATCTAGGCCGTGAAAATTAGAAAACTCGAATCAGA +TATCCTTGGCCGGAATGCGAAAAAACAAAAATTAGAGTTTTCTAGGCCAC +AAAAACTCGTCCACGTGTGCATGAACTGTCAAGTGGTCAACGTAAAAGGT +GTGAAACCCTTCAGAGAAAAACACTAGAAATGAGATAAAGTAGGTGAGAC +CTCCTGTCTCTGAGAAGCAACGTTCGAAATTCTTTTCCAATTCCATCTAT +TATTATTATTATTATTATTATTAGGACGGTATGGCGCCAGGAACTGGTTG +TTTATACTGACCACTGCCTCTTCCCGATTAGGATTCTGAATTTCGGATTT +CGGGAAATTGAGAATGGCAGATGGATGTAATTTCATTAATCATGTTCCTC +AATAAGTTAAGAAACAAAAGAAGGAAGATATAGTGAATCAGTGAGGAACA +AGAACATAGCATATATGGAATTGGCGGTGTAAGACTGGTTTACATGGTTA +CACGGAGGGAAAAAGATTTGAAAGTATTCGTCATCTTATCTAGGTAGTTG +AGACACTTGATTAGTCATAGTTGAAAGAACAAATGGAAGAAGTTCATATG +CTGAAAGCATCGCTAATAACATAATATTGGTTTTAAAGGTGGAGTACGGT +CTGTGGGTTTTTAACCTAAATGACAGAATACAGTCCCAATATACCGAATA +TAACTGTTAAAGATTTATAAAATTTATCTAAATTTTTTATGATTTTTAAA +AAAGTTTTTTTTTTTTTAATTTAAAAATTTATTCAAAATTCCAAAAAAAT +ATTTTATTCAAAACTAAAAACCCAAATTTTCTGAAACTTTACCATTTTAC +TTATTTATGTCTTAACAATAATATACACATATTAACGAAATACCCACCGT +TCAAAATTTGACTTAATCTCCAGTTTTAACTGCCAATGAGAATTTGTTCA +AAATTCCAATCTCACACCCAATGTTTTTCTTTGTTTTTCATTTTAAAACA +GTTCTATCCAGTTTAAAAATTTACCAAATAAAAATGTGTCTATTCCTCTC +ACCTCCAATCCCGTGCATGTGTTCATGTTTACCTATTGAAACGTGTGTAT +TACTATATAATACAGAACAAATATAAAATGGCCACTCTTGCACCTCCAGC +GGAAAGAAAGCTTTTGAGGTGTTACGAACACTGCAACACTTTCCTATTTT +ACTAGTTTTGAGCAATTTTCTGGTCCTTTTATTTATTTTTGTTTTGTCTG +GAACAGGAAGTTGTTTGTGTTCTGTTTGGAAAATTAATCAGTTCTACCGT +GAGATTTTTAAGTTATTTTTTGAATGGAATTTCAATTATTATTTCATTTC +ATTTGTTTTTTTTTCTCACCGAAATCCACTTTTTTTAGAAACAATTTTTT +TTTCTACATTTTTTTCCGATTTTTGTCATTCAATTTTTCAACTTCTCCAT +TTTTTCTACAAAACACCGAAAACTACAAAATACCTAAAAATTGCAAATTA +AAAAAATTTTTAAACATTTTTGCCCAAAAAATTGTTTTTTTTTTCAGAAC +ATCTAAAACTCACTAAAAAATATGCTCAAAAATTTTTTTGAGAACACTTA +ATTTTTCGAAAATCTTATTTTTGCAATATTAAATCCAGAGAAATTAGAAA +AAAAAAACGGTTTTCTACAGTACTCCTACCCTCCCTCTCCAGTACTCTTA +AAATATTCCTACAGTGTTCTTACAGTACTCTTACACCACTCCTACACTGT +TCTTACAGTGATCCGATACTACTTTTATAAGACTCCCACAGACTCCTACT +ATACCTATACCTTATCACTACAGTATCCCTGCCGTACCCCCCCCCCCCCC +CCAGTACCTATACTTGCCACTACAGTATCCTACAGTATTTCTACAGTGCT +CCTACACTACCTCTACAGTACTCCTACAGTACCATTACCAAAAATTTGAA +TAGAAAAGTGAAATTATGAACATTTTTTCCTGTATACCAATTTTTAAAGT +TTTAGTTTTGTAGTTGTTTTTGACAACGAAATCAATTTCAAAGTATTTTT +CTTTAAACAATCGTACTTTTTGCGTACTGTTCTTGCACTTTTTGGGATCT +TTTGGACTAAAAGTGCCCCCCGAAAAAAGCGCGGAATTAAAAGAACAAAA +ACCGGATAGACTGAGGAGGTGTCGAACGATGGAATGAAAAAAGAAACAGA +AATTAGATTTGGTTCAGTGAATTCTGTTTCTTTTATTTGGATTTTGGTTT +TTTGGAGTCTTGGAAAAATGTTTTATTTTTGTTCTTTCCAAGAGTCCAAA +CGTTTTTTTCCACCAAAACTCCAAAATTTTTAAAATTTGGAAATTTGATT +CACTGCCAAAACTTCCAGAGAAATTAAATGTTCAGTTTCCCGTAAATAAC +AGGGTTTCGTATCAAAAACTGTGAATTTTCCCGCCACCTATGTTTTTTAA +AAATGATTATACTCTAATTTCCCGTCAACATTTTTTTATTTTGCGAAAAA +TGATTATTTGAACATCCCAGAAAATTTTAAAAACGTCATGAGTTTTTTGA +AAATTCAATTTTTCGTGTTCCTGTAATAAAAACCATAGAAACTGTTGACC +TATAACCTGCCAGACGTTCTTCCTGTCTGTTTATACCCCCATCTGCTCTG +CACACCAGACACCCCTCCTCCTAACTACACTTTAAACTGTTACCCCCCCC +CCCCCCGTTTACCCCTCATTTGTTTTTTTTTCTAGTGCATCCCTTCCGTG +TAACCTGACACTTTTTCCAAGAAGCTCGCATTTCTTAGGAGGAGCAGCAA +TTTTTCGTTACTTAATTTTCCACACAGTAGGAAAGACAAAAAGAAAACGT +CATAGAAATTAAAAATTCTGCGTTTAATTTTTTGTTCAGTTTCTGAAACT +CAATTTTGTGGAACCGTTTTTTTCGATCTTTGTAAAATTGAATTTTTTTG +ATTTTTGGAAAATTTGGATTTTTGCTGGAAAGTCAATTTTTGTGAGAAAA +GGTTTGGCGGGAAATTTAAATTTATTGAGAAAAATTTTAGCGGGAAATTA +AATTTTTTGATAGTGAGAAAAATTCAATTGAATACCTTTTTTGTGCGAAT +TTTTCATAATATCTGAAACTCAAAAAATCTGAAAATTAACTCGAAAAAAT +TTTCAAATTTGATATTTTGGCAATTCAAAAATTGCTTAAAGAAAATAACG +GAACCTCGTTTTTTTTCTTTAAAAAAAGGTTTTAGTAACTTTTCCGGTAA +CCAAGGTTACTCTTTCCCCATCAATCTCCCAAAAGCATGCCAGAAAAAAA +AGAGAGAGAGAGAGAGATGCGTGTATGATTGTGTCATTTGACAGTGCGCA +ACAGACACACATAAAACAGCTGACATCTTCTCTTTTTATTTCAACTGATT +TTTAATTTCCCTCCTTGTGTTCTCTGAGTCTCTCTCATTTATTCAGTTTC +TCGATTTTCTTCCAAATTCATTAATATTTTAATCTATGCGTAAAGTGGAG +GAAGATTTCTTCTACGTTTTGATTTGCAATTTCTCGGGTTTTTCAAATTA +TGGATTTTGAAAAAAAAAATTTCTGAAATTTATTTTTGATTCATGTCAGA +AAATGAGTCTCCTGAATTTTTTTTGGAAAATATAAAACAAATTCTGAATT +TTTTTTACTTTTTGATGTGTAAAACAAAAAAATTGATTAGAAAAATCTTT +ATCTATTTTTTGAACTTTTCAATTTTAAAATCAAAATTAACTTCTAAGAA +ATAAGATTTTTTTCGGAATTTTGAAAAAAAATGTTGTTTTTTTGAGATTT +TAGTACATTCAATTTTCGTAAAATTCGAATTCATTTTTTTATTGTGCAAA +TGTTTTCTGACTGACTATGAGAAAAATTTCAACATTTTGAAGAACCCCCC +CCCCCCCCCCCCCCATTATTTGGACGGAGCCTGAATACGAAATGTGAGTT +CTCAGAGAAGGAGGTGAACAATTTGATTGATGTGCATATGGAGATGCTCA +TTGTGCATATCAGTTTGGAGCATCTATCTCAGAGTGAGCATGACATTTAC +TTTTACCCATTTGCGTAGGCTCCGCCATTTCACGATTTTTTTTTTCCAAT +TTTTGAACTAGTATAAAAATTTCTGAAATTTCTGTAATTTCTGCCATCTC +CTCATAAATTCCATTGTATTCTTTGCACTATTGTTCCACAAAAGTGCAAA +ATTTTCGAATTCGTAATGTGTCTTTCATATATATATCCATGCACTTTTGT +CCCTTTTCCTGAATACTAATTTGGTGTGCTCCAAGAGGAAATTTTTTTGT +TTTGTTGAAATTACTGCTCCTTTTCGGAATTTTTTAATTTCTGAGAAAAA +TTCAATTCCTAAATGTATAATACTAAAGTCAAAATACTAAAGTGTAATGG +TTTGTTTTTTGTTACAGTCTTTAGTTTGTAGCTTTTGTTTTGTGTAGTTT +TCCAACTTTTTTTTTGCCAAAATGAAGGCTGAGAAACCGAAAAAAAAAAT +TCAAAACATAGATTGGGCTGAAGCGGTATTATTGGTTTACTGTAGCATTA +CTGGGTTACTCTAGTTTGGCCCATGTTTGGTGTACGTTAGTAGTAACAAC +ATTTCGTTCATTTGTTTTTTGATTTGGTAACTTCTGGTGATTAAACTTTT +AATGTACCTAAATCTTCTGTTGCATTATTGATTTGTTGTTTTCTTCTTTT +TAAGTTAAACATGCTCAAATTAAATTCAAATTGAGTTGAAAATGCAAAAT +TATTATCAACTTGAATACCCAAAATTTTGGACGGTATTTCAAAAAAATTG +ATTTCCAGCCGCTTCGACCTTCGACACAACAAACGAATGCTAACTTTCCC +AGGATTACACAAAATAGGTCAAAATCCCCTTTTCTCAATTTTTTGCACAT +ACATCCTCATCATCATCATTGTAATGATCGTGACCATCCGGTCTTCTATT +ATTAAATGAGAGAAGGAAAGAGTATACATATGTGTCTTTTATATTAAACT +AATTATATTTCGACACATTCTGCGCATATCACTACTGCACTAGAATTACA +TTTTAAGAATAAAATGTAACCAAAAGACCAAAAAGTTGTTTGCATTTATT +GTTATAAACAGAATAGAATGAATGTTAGGAAACGTTATTAAAACTTGCAA +AGTGACACAATTCGGTATATCGATTTCTCTGAAATTACTTAACTTAGTAG +GCAGAGTTTTGATACTGATACGGATTTTACTAAATTTAATTTTTGTAAAT +CAGTATTGCTTTTATAACCTATTAAGATTTTTTTGTTCCAGCGTGCAATT +ATTTTTAATTCTATTTAGGATTTTAATAAATAGAAAAATACGTTTTGAAT +TATTTTTTACGTTATAATATTCAATAGTAAAGAAGCACACATCAATTCCC +CTATTCAGTTTCCATACTTTGCCTGATAAACATGAATAGTAAAATAGACA +CTTTCATTTATACAGACACCCCCCCCCCCTTGCTTCCGGATTAAATCCCA +ATAAAGGGTGTGGCAATAAGGCATTGTTGCAGTTTCATTGAATTTATTAA +TCATTTGACAGCATGAAATTACAAAACTGGAGAATTTCTAGTTTAAACTT +TTATACAATGAAGAAATCTTCCATAGAATCAATATTAAATTATCAATAAA +TGAGTATTTACGTTTTTCAGCAACGGTATTATTTTTATACTTACTAGTTA +TTAAGTTAGTAGTTAGTTACATTTTTAAATGCGATGCAGTCGAAATTTTT +TTATAGACTAGAAATTGTCTTAGTTTCCAGCCACTGACAAGTCGGCCAAA +TTTCAAACTTTCAGTAATTTTGCGTCATTTGTTGAGCCGCCATAACTCTT +TTTTTGAGACGTTTTCAAGAAGTTGAAATTTGGTATTTTCAGACATTTGT +ATCTTATTTAAAATATGAGTATTCACTCCTTTTACCTGCCAGTCGGCTGC +CTCCTTATCTCCTATTTTTCTCTAATGAGCACACACCACTATCATCATTA +TTATTACCACCTGTTCTTAATAATAAACATTTCCCGCACTTTATTTCCAT +TTCGATGCATTTTATAGAAAATGTTCCCCCTTTTCGAGCTTTCCAATTAG +ATTCACCCTTTGATTGCTCTTTCTTGGACGGAAGTGTTCCCCAATTCCCC +TTCATCTTATTACATTTTTATGCAGATTTTATTGCATTTTAGTGCGCTAG +ATTTTTCATGGGATTTTGCTAAATAATGCAATCACGCTCTAAATAAAATT +CTCAGTTTATATTTTAATGTTAAAACTGTGTGTAAAATTTACAAACATAG +TGAATACATTTTTCGAATAAAAGTATGAACATTTTTCGAGGGATCTATAG +AAAATTGCCGGCTGTTCCTAAATGCCCTTTCACTGGTCACCAAGTTCCTG +TTCATGCAATTCAAAAGAAATGTTCAGCCCCCCGCTCAATAGTCGCCCGC +ACCACAAAATTGAAAAGCGAACATTTTACTAGTCGAACTTTTGAATTGAA +CATTTTTGGAGTATTTTAAAGAAATGTTTTCAAGTCCACCAAAACATATG +CCAGGCCACAAAAATTTCAATTTTCCGCCAATTTTTTTCTCACAAAAGTT +GAATTTTCTCGAATTTCCGATAATTTTCGATTTATTTGAAAGTTATTGAA +ATTTATATTTTCTAAAACACTTCCACAATAACAAATTAATAGATATAATA +AAATTTGAAATTCCCATGCCACACCTCAAAAAGTGGCTCCCTTAACTCCT +GAGTGCTCGCGGAGCCCTACCAAACTTGGAACATTCTTTTCCCAACGGAG +TCATGAACATATGAGCATTAAATGAGTAGACGACATGTGTATACATAGGA +CCACCACAGCTGTTCCTTCCTTTTTATGAGAAGACATGTCATACACACAA +TGTCTCTTCTCCTTTCCGATTGGAAAATTAAAATTATAGGAGGGGGGGGG +GGGGGGGGCGATTCTTGACATTTCAATTACCCCCCCCCCCCCCCCACATC +CGTTATGTTGCATTTTGGTAGGCTTGGGGCCGAATAAGTCTCCCATGCAG +GCGTCAAAACGTCTGCGGACCTACGCCTGCCTCACGCCGCGCCTGCTGTA +CAGGAACCCGAAAAGTGTCGAACGCGGCTAAAGAACCACTTTTCGCACTA +TGCGGTGTAAACACAAGGTTTTGATTTGTAGTCATAGTGCATATATGATG +CGGGAGGCTGACAGGTAGGAGGCAAGCGTTCAACCGCGCATGCCCACCAT +GGAAGCCCTAGAGCCTAGTTTTAGATGAGTTTCAGCATTTTTGATCTACA +AGATTTTGAAAGTTTTACAAAAAAACCAAGATTTTTTGTAATTTATGAAG +TGATTTTTCTACATTTCATCTAGAAACCAGCAGAGTTATTTTTTGGGTAA +TTTATCAATAGAGCGCGTTCGCGTCATGAAAACAAAATGGCGGCCGAACT +TTGAAAATCGATGGCTGAATTTTTCGGAACAAAAGTCCGTAGCTATAAAG +CACAGGCCTACGTTTTTTTTGCTTTTAAATGACATAGTTTTCTAAAAAAA +AGTCTGTGGCCGAATTTTTAAATTTTGAATAGGGGCTTATTTCAAAAAAA +ATTTGAGGCCAACCTACTCTTCTCAATTATAACTTGCCATGGCAGAACTT +TTGAACAACTATTACAACGTTTTCAAAAAACAAGTTAAAGCATTTTTTCG +AATAAAGGTTAAATTGGTAGCCTAGTTTTCTCAAAACAAAATACTAAAAA +AAATATCGATGACCGAAGTTTATATTTGAAAAAATATGTGACCTAGAACT +TTTAACTACTCTTCCAATGTCTTCTAGCTTCTGAGAAAAAGTTCGTGGCC +TAAGTGTACCACGATGGTCTAGTTATCTCGGAAATAGCCATAGCCTAGTT +TTCTCAAAAAAATCGGTGGTCGAGTTTCCTGTATGTAGGCATGTAGGTAT +GTAATTTTTATCTTCCAGGTATCTATTTGTACTTCCCGGTAGCCAGGAGC +AATACTTTTGAATTCCTTTGCTCTCCCTATTCAGCTTCTCCCCTCACACT +CGTTTTTGGTATTCTATTGTTCTCCTCCTCTTCCCATTCTACCCCCATTT +CATTTTCCTCTTGGAGACCCCTGTCTCTCTCTCTTTGTATTGGCTCTTTT +ACGTCTTCTAGTAGGCTTTTCCTTAATGAACTTGTGTGTGTGTGCTTGAA +TCATCATCGCGTTCTCTCGTTCCATTTCCCTTTTGCAATTTTCTTTTCTT +GGAGAAATTTGGAAAGTTTTGCTCAAAATTCCTACGTACACATGCCTCAA +AATCTGGTTGTATATGGCCTAACATTCAATTTCTAGTGCACACAATAAAA +TTTTCCGGGAAATTCAAATTTTCTGATAATGAGGAAGGACTTTGGCGGAA +AATTCAAATTTTAAAAAAGTAGGCGGGAAATTCGAATTTCGAATTTTCTA +AACTTTTTGGCCGGAATTTCAAATGTTCTGAAAAATAATTTTGGAGCGAA +ATTCATATTTTCTCAGAAAAATCTCAGAAAATTTGAATCTCCCACTAATA +TTCTTCTCAAAAAACTGTTACGTGACCTATTTATATCTTATTTATTGGTC +CATTTATTACGTGGCCTAAAACATTTTTTCTTTTCCCCCGTTTACAGCGA +TCATTTGAGATGGCCTAGAAAACGCACGTTAGGCCATCAGGTTTACGGGG +TATAGTACAACCTCTTGCAGGGGACTGAGGTTCAGAAAACTACAAATTTA +GCTAATTCCCTACCTACTCTTGCAAATCCAATAACTAACCCAATTTCCCG +GGGAAATTTTTATTCTTAGAAAACAACTTGTATATCTCCGCAACTACATA +TCCCTCCTTCAAAATAATAATAATGGGAAGCTTCTGCTTCTCTACACCTT +CTTTTGACCAAAAACTTGTTGCCAGTGCCCTATTATGTACGGTCCGTTGA +GTTTTGTTGTTGTTCACAATAATATGTGTAATTCGCGCATCTGAAGAGGG +GAGGTGTAAATGTTGTGTCTAACCGTTATGTTGCTGTCACCTCCAAGTGG +TACAGGTGGCCTAGAAATTTGCGAAAACTCTTCCACGATTATATTTCTCA +AAAAATTACTTTTCTCAGAAAATTTGATTTTCTCACCAAAATATTTCTCA +GATAATTTGAATTCCCGCCAAAATTGTTTAAAAAAATAGAATATCTCGTC +AAAATTTTTATCAGAAAATTTGAATTCCCCACTAAAATTTTGCCAAAACA +TTTTATTTTCCCACTTAAAAAAGTTTTTTTTTTAATTTGAAAGTGGAAAA +GTTTTCTAGGTCACTTATACATTACCGGTGACCGAGGTCGAATTATTCCT +AGGCCACAAATCTCCCAAAGGGGTATTCCCACACCTAATTGACACCTCCC +CGGGCACCTTTGAGCACTAAGTAAGGACACCCACCCCTCTCAGCTTAATA +GCTTTTAAAGGAGCACACCAGCCATATGTTTTCTCTAATTCTCTCACTCT +CTCTCTCGGCTTCTAAATTCAATTTCCCCCCGTCACGCCTCTCGTTACGT +GAGGAGTGTTCAACATGTTCCCATTCCCTTATCCGATAAGTTTTTGGTAG +GCAGGAGCTTGTACTAGTAGAGGACATTTGTCGCTTCTTGGTCTTTCGCC +TCCATTTTCCGTAATTTATACGTGACTTAGAAAATTAGAAAAAAACGCAT +TCCACGAGTTTGTTGGACAACTTTTTTTACGTGGCCTAGAAAAAAATGAA +ACTCGGCCACCGACTTTTCTTTCACTTTTGTGAAGATATGATCTCATTCT +ATAATTCTGTCGAACCGATTAGGAGGGTGGCTGAGTTTGCACTTTTGCGT +GTTCTATACCATTTACAGAAGCTAGTCCCCCCGTCATTCTTTTTCCTGCA +AAATGTTTTTTTTTGCCCCCGGTGTCTCATCATACAGTACAGCAGCCAAT +ATTATTTGTTTTTTGTTTCGTCTTTTCGTCTTTTCGGAGAAAAAACGCTC +TATTCTATGACAAGGTGACGTCATTGGACTCGTGGCCTAGAAAGTTTGGC +AAACTCTTCCACCATTCGATTTTACAGGAGCCTCAAAGCCCCACATGGGG +CCTAGAAATCTTGACATTTCTAAAAAACATCCATTTTGAAATTTTTCGAA +ATTGGTGCAACCTAGCAACCTCTAGAACTTCACGTGACCTAGAAAAAACA +AAACCTCAAAATTTCATGTGGACTAGAAACTTTTAAAAACTCTTCCATCG +ATTTTGTTTTGTGGCGGGGACTTTTTCCAGTTTCTTTTTCACATAAAAAC +CAAAAAAAAACAAGACGTCAAGCTGTGAAAATGATTAGTCACAAAAAGAA +GAAAAACAGTAGTGTCGTTCCTGCCAATTTCAGAGATTCCTTCTTCGCTT +CTCACGACACGAGGGGGGGAGGGTCTAATTGGCACCCCCCCCCCCCCCTA +CTGAGGTGAGAAGCTTGAGTTGACTCACACGTCGCTCTTGTTTTATTCAT +TTTTGGCACAAAGTGAAGTGTGCGAAAATTGTAGTAGTCTGTGTGTGTGT +GTGTGTATGAGCATTTCGAATTTTAAAATACTTTTTTAATGTACCGCAGG +CCACGTGGTAAGTTTTTTTTCATAAATATAGGATTTGTTTTCTTGTAGAA +AAGTTTTTCGAATTTTGAAATGAAAAGGATAACTGGGAACGGAGAAAAAT +TAAGTTTTAATTTCTAGGCCACGTACCAATGAGGATGAGAAGTCGGTTTT +CTAGATCACAAGGTCATCTAAACTTTTAGGAAATTTAAAAAGTTTGGTGA +TTACGAGAATTTCTAGGCCACGTCGCAATACACCGGCGCGTTGGCGTTTT +TACACTTTCTAGACTACTAAGATTTTCCTAGGCCACGTCCCAATCAGGGC +TGTTGCAAAAAAAAATTTTCGACCAAAAAACAAAAAACAAAAAATTTTTT +GGTCTAACTATGGACCAAAAAACAAAAAACAAAAAAACAAAAAACAAAAA +AAAATTCAATGTTTGATATTGAACGGGACAAAACGGAATTTTTTCATGAA +ATATTCTGGTGATTTTTTATAAAATATTGAAAATTGAACGAACAGAAGGT +TTTTTGTTAGCTTTTTTGCTGAATCAGTGCTGTAATTTATTTTTTGGTTG +TTTTTGGTTTTTTTTTTGGTCTCAAAAAACCAAAAAAACCAAAAAATCAA +TTTTTCCCAAAAATACCAAAAAAAACCAAAAAAAAACAGCCCTGGTCCCA +ATGTACAGGTGTTGTGGTGCTTTTTGTGAGCTCTTAGGCCAGCTGGAGTT +TTCTAGGCCACTTGTAAATCAATGGTTTTTTTTCGGTGTTCTAGGCCACC +TGTCACGCCTAGACCATTGACCTAGAAGTTTAATGTTTTTGAATAATAAG +TACACGTACTCTCACATACCCGCAAATGCACATATCTATCTTCATTTCGT +GATTCTCTTCATCTCATCTTATTTTCCATTTCGGTTTACCCTTTTTTTCT +CTATGAATATATTTTCATGTACTTGCTCTTCTTCCCTGAAAAAGATTCTT +TTACACTTTTTTCATTTCCTTAGGCAGTTGTAAAGAACTTGTCATTAGAA +CTTTCAGAATGACATCAGAGTAGATGGCCGAACTTTTTCTAGGCCACGGC +TTGGGAGCCAAACATGGCTAAACATTCTAACTTCCTGGGTCATCTAGAAG +TTTCTAGGTCTTATGGGTGAAAATTGTCAAATGACAGAATTTTCTTAAGT +TATAGTTGAATTTCCCGCCAAACCGATTTTTTTTTGAAAAATTTAAATTT +CCCGCCAAAAATTTTTTGAAACGTTTAAATTTTATGCCAAACTTTTTCTG +AGAGAATTTGGTTTCGCTCCCAATTTTATTCTCTGAAAATTTTAAATTCG +CACCAAATTTTTCGAGAGCTTTTTGAAGTTCCCGGCAAAATTTGTTTTCG +AAAAATTAGATCCCCGTCAACTATGATAGAGAAGTTACGTCATCTGGCTA +CCCTGGCCGAATTTTCAATATATTTCTAGGCCACATATTGACCGCTAAAT +CATGTTGTGGAAGAGTAGTGACGTCACTTGGCGACCGCGACCATCGAGCA +GCGTGAGGGGCGAAGTATCCCCCTTCCCAACCCTAAAGACGTCGTTCATC +GCTCCTTTTTTGTTGTTGTAGGAGTTCCGTTTTTTTGTGTCTCGATTCGT +TTCCTCCTGTTTGTTGTCATTTCTGAACTCATCTCTACACTTCTCTCGTC +TTCTCTGCGTCTCTCCATCCTGCACACTATTTTTGTTTACCTCGATGATC +TTTCTTTTTGCGTGTGTGTCACTGACGAACGAACGGCTGACACAGACTAT +TGTTTTAGTTTTGTTGTTTAGAAGTAGTTGTAGTATTCCAATAGTTTTTC +ACACTTTGCATTATTTCAGATGGCTCAGGACGGAGACCGCCATCACATTT +TTGTCAGTGCTCCGCCGCCGCCGCCACCTTCCTCGTCGATTCCAGCTCCA +TCGCAGGTAAATTTAAGGTTGCAAGCGCGCTCTAATGACCTTTTTTGTGC +CTCCGGCTCCTCTTTGGGTTATTGCCAACGCGCTCCAATTCGAATTATTC +TTACTTTCAGCCAAATAGACTGGAAAAGGAGCCGCTCATCGATGAGGAAA +CTGACATGATTGACGAATCCCGAGCCACGTATTGGAAGGGATGTGAATTC +TTGAAAGCCTCTGGGTTGTACTCGAGTAAATGTGAGTTGGTCTAGAAAAT +TTGTAAAGCTCTTCCACGAAGTAATTAATAAGGGATACTATTGCCGACAC +CCAGGAACACGTATACCACGGAATTCAAATTTTAATTTTTTGAAAATATT +TTGGCGGGAATTTAAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATT +TAAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATTTAAAATTTTAAT +TTTTTGAAAATATTTTGGCGGGAATTCAAATTTTAATTTTTTGAAAATAT +TTTGGCGGGAATTTAAAATTTTAATTTTTTGAAAATATTTTGACGGGAAT +TTAAAATTTTAATTTTCTGAAAATATTTTGGCGGGAATTCAAATTTTAAT +TTTTTGAAAATATTTTGGCGGGAATTCAAATTTTAATTTTTTGAAAATAT +TTTGGCGGGAATTTAAAATTTTAATTTTTTGAAAATATTTTGGCGGGAAT +TTAAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATTTAAAATTTTAA +TTTTTTGAAAATATTTTGGCGGGAATTTAAAATTTTAATTTTTTGAAAAT +ATTTTGGCGGGAATTTAAAATTTTAATTTTTTGAAAATATTTTGGCGGGA +ATTTAAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATTCAAATTTTA +ATTTTTTGAAAATATTTTGGCGGGAATTTAAAATTTTAATTTTTTGAAAA +TATTTTGGCGGGAATTTAAAATTTTAATTTTTTGAAAATATTTTGGCGGG +AATTTAAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATTTAAAATTT +TAATTTTTTGAAAATATTTTGGCGGGAATTCAAATTTTAATTTTTTGAAA +ATATTTTGGCGGGAATTTAAAATTTTAATTTTCTGAAAATATTTTGGCGG +GAATTCAAATTTTAATTTTTTGAAAATATTTTGGCGGGAATTTAAAATTT +TAATTTTTTGAAAATATTTTGGCTGGAATTTAAAATTTCTGAGAAAAAGA +ACCTTCGTGTCGAGACCCATCGTGGTGAGACCCTTCGTGGTGAGACCCAT +CGTGGTGACACCCATCGTGGTGAGACCCTTCGTAGTGAGACCCTTCGTGG +TGAGACCTTTCGTGGTGAGACCCATCGTGGTGAGACCCATCGTGGTGAGA +CTCATCGTGGTGAGACCCTTCGTGGTGATACCCATCGTGGTGAGACCTTT +CGTGGTGAGACCCACCGTGGTGAGACCCATCGTGGTGAGACTCATCGTGG +TGAGACCCTTCGTGGTGAGACCCATCGTGGTGAGACCTTTCGTGGTGAGA +CCTTTCGTGGTGAGACCCATCGTGGTGAGACCTTTCGTGGTGAGACCTTT +CGTGGTGAGACCTTTCGTGGTGAGACCCATCGTGGTGAGACCCTTCGTGG +TGAGACCCATCGTGGTGAGACCTTTCGTGGTGAGACCCATCGTGGTGAGA +CCCATCGTGGTGAGACCCATCGTGGTGAGACCCATCGTGGTGAGACCCTT +CATGGTTAGACCCATCGTGGTGAGACCCTTCGTGCTGAGACCATTCATGG +AGAGACCCATCGTGGTGAGACCCTTCGTGGTTAGACCCATCGTGGTGAGA +TCTTTCGTGGTGAGACCCATCGTGGTGAGACTCATCGTGGTGAGACCCTT +CGTGGGGAGACTCTTCGTGGTGAGACCCTTCGTGGTTAGACCCATCGTGG +TTAGACCCATCGTGGTGAGATCTTTCGTGGTGAGCCCCATCGTGGTGAGA +CCCATCGTGGTGAGACTTTTCGTGGTGAGACCCATCGTGGTGAGACTTTT +CGTGGTGAGACCCATCGTGGTGAGACCTTTCGTGGTGAGACCCTTCGTGG +GGAGACTCTTCGTGTTTGATATTATATTGGCGGGAGCTAAGGAGTTGGTG +TGGGATAATGTCAAGGTACTCTAGGGGTATTGTGGATTTGCTGTAGGGTT +ACTGTAGTTCAGAAAAATTGACTTTGTGCTTTTGAAGAGGTATTGGCTCG +AGAGTTAGAGAGGCGGAAGCTTCTGTGATATTTTTTACATTCCAGAATGT +TTGAAAAAGTAAAAGTTTCCACCTGTTTTCATGTGACATTGTTAAAAGAT +TATATGGTGTTTTATGTGTCGAACAATTTAAATTTCGCCAGTCGTTGGCC +GCGCCGTAGGCGCGGTCAGCGGCTGGTTTTTCCAGAAAAGGAATAAGAAA +TAAATTATTTGGAAGTTACTAGGACCCTGAATAGAATTCTAGGCCATATC +GAAAAAGGGGATGGGTGCACGTGGGAACCTTTTTTTGGATATTTTGGAAA +GAAGTAAGAAGTAAGAAGTAAGAAGTTGACTTAAGAAGTTGACTTTTCTA +GAGTAAGAAGTTGACTTTTCTAGAGATCATCTCCCCTCTATTATTCTCAG +CGTGACCTAGTTATCCGGAAAACTCTTCCACCAAAAAATGAGTGTCTCCA +ACTGAAAAATGCGTCATAAAACACACGGAAAAGGTACTTGTGTATTACAT +GCCCTCATTTTAATAGTAGTTTTTTAAGCCATGAAAAATAAAAACGTGAA +CCACAATTTGTATTTTTAGGCTTAGGAAATAACATTTTCTAAGCCTAAAG +AGGAAAATGTGTAATACACAAGTACCACGGAAAATTTTTTGAAACCTTCC +GAATTTGAAATAATTTAACTAAAAGTTTCTAGGCCACGATGAAAATAGAA +ACAATGATGTCCCGATTTTGCTGAAAATTTCTGTCCATAGTTATTTAGAG +TTCTGAAAAAAAAGATTTTCGAGAAATGATTTTCTAGGCCACCAGAAAAG +TTTCTAGGCCATTATCCCTTCTTGATCCTTTATCATTATGATTATGATAT +TTTTTAAACGATTTTTTAGGCCACCAGAGGGAATTCTAGTCCGTGTCAAA +AAAAAAAGAAAGGGGGTATTCTTTCCACATAAAAATCCCGTTGGCCTTTT +CAATCAAATTTCTTCAATTTTTCGCATAAAACTTACCTCCCGCTGTGACA +AGCCTCCTCCCGTCTCCCAGTATTCTCAATTCATTAATCATCACCCCCAA +TGCCCTCATCAACTACAGTATCCCTGCAATCCGCGTCTGCAAATATGTGC +CGAATATGTCATACTTCTACGTCAACGCGGTCAAATCCGCTCATCTCACC +GTGTCGATGCTCTGGAACACTGCTCTTTGTGCATAAGGCGTGTGTTGTGG +TGAGCTCTTTTTTTGTAAAATTCAAAATAATAATTAAAAAATTTAAAAAA +AAACCTTTTGTGGAATTTGCAATTTTTATAAAATCGTTAAAAACCAAATT +CAATTTATACAAATTTCCACATTTTCCAAAATAAAAAGAAATAGCCATGC +CCACAAAATGGGCGGCGCTTTCATAGCCACGTCCATTTTGTGGGCGGAGC +CTCGGATCAAAGTTTTTTCAAAAACTTACTATAAGTTGAACACGGATTTC +TGGCTTCCTTCATAAATCGAAATGGCAGAGTTTGCCGAACTAGGCCATTT +TGGGTCGGAGAGATTTTGTGTAGATTTACGGCGTGTTGCGTGTCGCGTCG +CGGCTCGTTTTTAGTTGTAAAACTGCTGTATTTGTCCGTGTGGAGTACAC +GATTTTTTCCACGCGCTGTCCGGCAGGCGATTGTCAATGAGGAGCGAAAA +TTCAATGCGAAAGGCCAGAAGCCCGTGGTTGAAGTGTGGTTTCAATATTA +CAGAAATTTTAAAGAGGAATAAACATGCCTGCCTACAAAATGGGCGGAGC +GTTGGAGGCGTGGTCTAAGAAGTCACGCCCTTTTTTTTAAATACTTGTTC +TGATGTACAATAGAGCGCATTTACATCAAATTAATAATTTGTTTTTCAAT +TTTTCCAGAGATGGCTGGAAATGTCGACTCGAAAAATGGTCCCATCACCA +CGTTGCGAACTATGCGGCTACGATTATCGACGTGGAAATATATTTCAAAT +GAAATCTTTACATGTTCCACACGTGGATCGATCATCTTGTCTGCTCAATG +TGCTCTTTTTGATTACCGTATTAATTATGATATTTTGTGGATATTTTACG +ATTCAATTCATTCAGGAGAATGCACTCTTAAAACGAAGGTGGGCGAAGTT +TTCTGGTGATGACCTAGGAAATTAGAAAACTAGGCCACCCCGCAAATGTG +GTGGCCTAGAATACCGAAATTTGACTAAGCTATGGCCTGCGGCCTAGAAA +AATAAAAGTAGACTGTATAAAATTCTCATCAAGCCTTTTGGAGATGAACT +GGAAACCCAAATTTTTTGGAAGAAAATATTGACCTCCTTTAAAACGGTGG +CCTACTTTTTCTGATGGCCTAGGATTTTAGACAAAGAAGCCACACAGCTA +CTATCCACATAGTTTCAGGAAAAAAAATAAGAAAAATAGGCTCCGCCCAC +ATATTCTTTTGAATTAGAATATACACGAGCCATTTATTTTGCTAAGTTTT +GAATGTTAGCTCCGCCCACATAATGATTTGAATTTCCCGCCCATTTTTCT +CTCAAAAATTTGAATTCCCTGCCAAATTTTTTTTTGCGAAAAACTCAATA +CTTTCAGGCTCTTCGCGCACAGTTCGACAAACACAGCGTACACGTGGAAA +CGGCGTGGCTATTTCAGCGGAAACGGGAATGGAGACGGGGACGGTAGTTC +GGATGGATATTTCTCGCGTACACCTGTCTCATCACTTTTTGACATAAAAG +TGGTCTTGTGTGCCAGCATGTTCTTGGTCTCGTTCATTTTGGCCCTTTTT +ACACAGTATAAGTGAGTTTTTTGACACGTGGCCTGGAAAATGAGAAAACT +CGGCCACCGATTTTTTCAGCCGAATTTTTTTAGTTTAGCGGTCACACGGG +CTTCTGGCCATTCTCTCTGCATTTTTCGCGCTCCATTGGCATTGGCTTGC +CGGACAACGCGTGGGAAAGTCGTGTACTCCACACGGATAAATTTGTTCAG +TTTTACATTGAAAACCGAGCCGTGACACGCCGTAAATCTACCCCGGCCGT +GGCCGAGTCAAAATGGCATAGTTCGGCAAATTCTTGAATTTCAAAATATG +ATGGAAGCCTGAAGCACGTGCGGTCATAAAAATCAATAAATTATCTTTTT +TTTCCAGAGCCGAGTCCACGATATTCCGATGTATTTTCCGATTTTTTGTG +ATCAATAAGAATTGGATGATCAAAAACTACGATATCAAGTGAGTGGGCGG +AGTGTAATTTCGGCGGGAAATTCAAAATTTTTCAAATTTTTCAGAAAAAT +TTCGCGCAAAGTTCAAAAACTCAAAACTTTCGGTAAATTTCGGCGCGAAA +TTCAAAATGTTAAAAATTTTGGGGAAATTTTGGAGGGAAAATCAATTTTA +AAAAACGTTTGTTTGAAATTTTTTTAATTTTCAGAAATGATCCCGAAATG +GCTCACCGCCGCGGTCTCCAGAAGTCTTCACCTGTTCCGTTAACCTTATC +AGCTTCTGATATGTGTATCCACGTGTCATCCTAGTCAACAATTCAACGAA +AAAAACCATTCCAGTTACAATTTCTCATTTCTTTTCACCACTTTCGGGTT +TTTTGCAAATTAAAAAAATTTCGATTTTTTTTTTGAAATTTTAATTTTCC +AATTTTTATTTTTATTCCACAACTCAGGTTGCTCAACAGTGCCTAAAATA +AATTTTATTTCTTTGATTTTTTATAAATTTACAAAAAAAATACAACAAAA +AAATAATATTACACATTCGTGAAAAACGGAAAAAAAATTCAGCCTATTTA +CATTAAAACACGTGGAATTTGAAATTTTAGCGATATATCGATTACCCTTT +CTCGGAAAACTCGTAATAAATGTGAAAAAGGCGAGGAAATTGGAAGAAAT +AAATGCGGGGGTTTCTAGAAAAAAAAATTGGGAGAAAGTTTAAAGAAAAA +TTCAAAATAATGCTCCGGTGTCATCGTGTTCCACAGTGGTTAGATTCTGG +TATTTTGTGCATGGTGTGCTCTGAAATTTAAAAAAAAAGTAAAAAATTGA +AAAAAAAATTTCTTAAAAATTAAAAAAAATGAACTTTTTTTTAAAATTTA +TATTCAAAAATAAAAATGTTTGGTATACCTAATTATTCATACTTTTATCA +ATTTTCGAGAAACTTCAATTTTTCAACTGCTAACGTATACAACTCGCGTT +ACTCGAAAAAGACCTGGGGACTAGTTTCCCACTTGGTGGCCTAGAAATCT +CCAGTAAAAACATCGACGACCGAGATATGAGTTTCTAGGCCTCCATATGA +AAAAAAAACTCGGTCGGGGACTAGGTTTCCACATGATGGCCTTGATAACT +TCAAATTTTTTGGTGACCTAGATTTTTCAAAACTTGGATTACTAGGCCAC +TAAAAGCTTTTCGGTGGCCTAGAAACCAAAATTGCGTGAATTTTTCATAA +TTCTATATCAAAATTGACTAAACCGAAAAGAATGCGATGCTTTTGCAATA +TTTCAGCAGTTGGTGTATCCCACGTGGCGACGGGATTTCGGGCGACCGTG +CCATTGATTAGAGCCAACGGAAGATATTTTGAGCATTCGGCGGTGCTCTG +CAAAAATTTTTTTTTTGCAAAAGTTAAAGACGCATGGTGGGTCTTGATCT +ATGAAATTTCGTGATTATTCGAAAATTTTTTGTCCTTATTGACAATTTTT +TTATCCACAAAAAAGGCGGATGTCCTAATTGCCAAAAATGTGGGTTTCTA +GGCCACGAAAAATAATTTTTTGCTTCAAACATCCTGCTTTTTTTCCAAAA +TTTAGCTTTAAAAAGTCGGTGGCCGAACTTTATTAAAAGTTCAATTTCTC +GGCCACAGAAACTTTGTTTAAGTTTTCACATTTGGATTTCTAGCCCACCA +ATAACGTTTTTATTTCATATTTTTATAAAAATCGAATTAAAAGTAGATGA +TGACCTAGTTTTTTTTCAATAATTTGGGTTTCTAGGCCACCAACTTTTTT +TAAAAATTTTCTTAATTTTCCATAACCAAAAAAAAAAAACAAAATCGATG +GCCTAACTTTTTGGCTTCCTAGGCCACCAATAACTCTTTTATTACTAATT +TTCCTCACTCTCTGATGTCGATAAACACTTTCTTGTCTCGAATATCGCTT +CCCACACCCATCACACTCAAATGCTCCATTCGTCTCATGAGTGAGCAAGT +GTTGATTGAGCCCATGCTTTTGCCGGAAAGTTTTCTCGCAGTCTCGACAT +TTATAAGGTCCATTGTTGGGCTGGGCCTCGTGAGCCGACGACGGGGCCGC +CCGTTTTTTCGCCCTTTTCCCCGATTTTTCCGGTGAAAAAGTGTCGAAAT +ACGCGTTATTGTCATCTAATTTTGGTACATTCGCCAACATTGCTAGATTC +TCCTGAGCCACCTGTTGTGACGTGTGAGGAATGTGATGGTGCTGATAGAG +GTCTGGTGGTGGCTGAAAATGGGGAATATTCCCGGCGCCGAACATTTTCA +GAAGTTCCAGGTCGAATCGTTGTTGAGCATCCGCGTCGACTACTTGATTG +AGGGAGACGGTGAAGTCAGTTGAGGAGGTGGATGGCAGTTTTATAGAGAA +ATCCTGCAAAAACTCAGGTTTTTGCTAAATTTTTCAATTTATCATTGTAA +TTTCCGAAAAATTATAGCTTAATTTTTAGATTTTTCGCTTGATTCTCAAG +TTTTTATGCGAAAATTTAGTTTTTTGTCAATTTTTTTTTGTTTTAAATGT +AAAACTACGGTATTTAAAGGGAGGAGCACTAATTTATGCCGATGGGTCTC +GCAGCGAAAACATTAAATGCCTTAATTTAGCCATGCGCCTGGAAGGTTAC +TGTAGTTTTTATTGATTGATTTTTCATTCAATTTGTGGTTTTTGAAGGTT +TTCAACTCATTTTGAAAGGCTTTTATAGATTTTTTTTTCTGAAAATCAAA +TTTAAATGTTAAAATAATTTTTTTTTTTTTTCACACAAAAATAACAGAAA +TTCCGAAAAATTGCAATTTAAACAGCTCTAAAATATGAAAATTAACGCGA +TTTTTATCATTTTTTGCTTCAAATCGCTGACTTCTGGCAAAAAAAAGGAA +AATTCAGCAAAAATCAATTTTTCAGAAAAATTTGATTGATTTTTGGAATT +TTTCTTACCAATCCGTCGTCTTGCCGTAAATCCTGTAGCTTCATCTCCTT +AGCCAGCAGATTTCTTACATCTAATTGCACGTGGCAATTGCAGTTCTGAA +AAAAAAATGTTTTTGAGATTTTTAGAAAACTTATTTTGTAAATGTTCTAG +GTGGGTTTTCAAATTTTTTTTTAAATTTAATTAAATCAAATTCTTCTCAC +CGTCAGTTTCTCTTTGACAAAATCGCTCAAATTCTTCTGATTTTCCTGAA +CTTTCTCCACTTTCACGGCCAAATCCTGCTGCTCACGCAAAAATTGTTTG +ACAAGACACGTTAGCTGGTTCACATTTGATAGATTGTCCGGGATTTTTAT +AATCTGAAATTTGAAATTAAGGATTTTAGCGGTTTTTTCGGCAAAACGTA +AACTTTTAACGCTGAAAACTCACATTTTTCGAACTCCGCTCCAATAATCG +TCTAGTGAATTCTTGAATAAATCCGGTTGCTTTCATAAAATTCTGAAATT +CCTCATTTCCAATGAATTCGCCCATTTTCCGATGGAAGAAAAACCAATGG +AAATACGGCAATATTTGCGCACAAAATCGATGCTGAAGTGTCGTCGGACG +CAGTGTTTCGTGTGCAGTACACGCCTACGACAAATTGCGGACTTTTTTGT +TATGGAGAGAGTAGAATAGAGAAGAAAAAAGAAGATAAAATGGATAAAAA +TTGCGCGTTTTTCTCGTTTTTTCTCTGAATCTCTCAATTTTTAGGTTTTC +GATCCATATACGTCCCGAGTGGAGATGAAGCCATAAATTTTTCTCTAAAA +ATTGTTTCTTGCCCCTCCAAATCGCTTATTCGTTTTTAAAATTATGAAAA +AAAAATGCTAAAAATGCTTACCAAACCGCAAATTTTTAATTGGAAAATAC +CCAATATTTTGCAATTTATAGTTTAAATTCAAGAAGGTGCCAAAATTTCT +GCAAAATTGCATATCTTCATATAAATTGTTACATTTTTTGTAAAAACTTG +AAAACCCTGCTTTTCACATAATAGTACTGGAATTTTTCAATTTTCAACAA +TTTCATAATTTTTGACCAATTTTTTATTGAAATTTTCAATAAAATATTTA +AAAGATGTGGCTTTCCAAGCAGATTTTCCAATTTTTCCGAGTTTGAGTAA +CTAAGTTTCAACCAAAATGATGTCACAAGTCAGAAAATTTCCCTAAATTT +CAAAACACAGGTGAATAACTATAGGATTAGAATCTGCAAAGATTGAGTCT +GGAGATAATTTCGGACATTTTTTCGGATAGTTTACGTTTCCTGTAGTTTC +AAATAGGCAATTTTACTTTAAAGGTTGCTAATAAAATTAAGAAAAATCCT +TATATAGTCTCCACCCACAGATTGGCTTTTTAGATATTTTCAAAATATCT +TGTAACGAAAACTACAGTAATCTTTAAAATTAAAATTATTACTGTATTGC +TTTTGTCCATTTACGGGCTCGATTTACGAAATTAAATTTAATAATCTTTA +ATCTATAGAATATTAAAATTAAGCAAAAAATGAGAAAATAATACGAAGAA +ATGAAGGAAAATGGAATATCGGTGTAACTATCCGAAAATAAATTCATTTA +GAAAATCGAGCCCGTAAATCGACGTTACGAAGAATTACTGTAGTTTTCGC +TACGAGATATTTTGCGCGTCAAATATGTTGAGCAATACGCATTTTAAGAA +TTTACTGTTATCGTAATAGTTCAAATTTTTCGAGATAATAGTCTTCCAAA +AAACTATTGTTTAAGGTTTTATTTTTTCCGTAATCTAAATTGATTATCAC +TAGACACTGTTCATTAATCATTCAGAACTTGTATAATCCATCTCGGTTAA +ATTGTTGGTGAGACAAAGTGTAATCTGTTCTAGTTGGGTCACACGATCCC +TTTTCCACTCAATCGCTTACCCACTCAACACTATAGACTAGACACTCACA +CAGGAAATAGTATTGTTTACCTGTTTTCTTTTGGACACTGTTTATAACTT +TTCCCTCTCCGTTTCTCTACGTTTAAATTTGTCAAAAATTAATAATTTTC +TTACTTCCACATTCAATACTCATTTAATGACCGGTATTTGAAAATATTTT +AATTTTTTAATCTTTAGTTATTACAGGAACAGTAAACTCTGGGAATTCGT +ATTGCACAACATATTTGACGCGCAAAATATCACGTTAGCTGGCATAATAT +TAGGCATATATTGTTTCTACAATCTTGTAATGTATAACTGACTAACATCT +TTGAAATAAGTTTGTAAAACTTGTGAGTTGGAAAACATTGTGCATGGATG +TCGTGTTTCGCGCACGCGCTAGAGTAGTCATAAAAAGATTACTGTAGTTT +TCGCTACGAGATATTTTGCGCGTCAAATATGTTGTGCAGTATGCATTCTC +AGAATTTTGTGTTCACGTAATAAATTAAATTGTTAAAAGATATAATAAAA +GTTAAAAGATATAACAGATTTTTTCTCACTTCCCTAATATGTTTAATAAT +CAATCATTTTAAATTGTGCCGAAAATTTTCCGTTTTCCAATTGTTCGGAA +TTTTTTCGGTTTTGCTCGAAAAAACCAAAAAGCAAATTTTTATAAATTTC +CCTGGTGTTCAAAATTTTCCCGCAATTTTTACCTATTTTATTTTCAAAAT +ATTTATTTATTTCAGTTCCCCCAAGTCAAACCGTTCGATGTTGTAGAAAT +GGAGATAATTCCGCTGCATTACGGAGCACAAGTTGGGATTTATGACGAGG +ATCATGAGGTTGGTAGATTTTAATTTGTTTTTTAAATCGTGGCCTAGCAC +ATTCTAGGCCACAGGTAGTGACGTCACTCTGAACATTTTCAATATATGTA +AATTTTAAATTCAAACTACTTAAAACTCGGAAATCACTTTTTCCGTCAGA +TACACAGAAATAAACTAGTTTTACCTTTTAAAAAACTAAAACCATTGAAC +TTTTCACAAATGTTCTTTGAAACTTGAGATAATCTGCAAATCCCAAACTA +TTAAAAACTGAAAAAGGTAGCCTAGAAAATGAAAATTTTCAATAGTTTTT +TCAAGTTCAAAGAAAAAAAATTGAATTTTTAAATTGTTTTTTTTCGCTAC +AAGTCAAAATTATATTATATTTATTAGTTTTTTTCAATTTAAGAACATTA +CTAAAATTAGTGCATATTTAAAAAAAATGTTTGTTTCGGAGAAAACAACT +ATTAGTAATTGCACTGCAATCATCAGATTAGTGAGGAATTTAGTTCTATT +TTTTTCTTTTTTTTCTGTTTCAAAGTCGTTTTTTCATGAAAAATAGACCT +TCGAGCTACTGGTTTTTTGAGAAATATTATTTCAATTTTCAATTTCATGA +TGAACAACATTTTTGGTAACACATTTAATTCTAGTAGAATATTATCCACT +TTTTCTCTAATTTTTCAAAATTTATTCCTAAGTTTTTCTGATCAATGAAG +AACTACCTTTTTACGACAATATTGCCTTCAATTTTTTCTCTCTGAAAATT +CGAAATTTATCTGAATCAATGGTGCCGGTTTTCTTATTTCTGAATAACGA +AATAGATTTTTTATTTATTTTTCAACAATTCCCGGAAATTTCTCTATTGT +TAAAAACAAATGAAGTGAAAATCGATTTTTTTACTTCGAAAGTTTAACAT +GAAATTCGATAAATTTAATCTATGATCTTTCAAGCTCCGCGAGTTTGAGG +CGGGATGTTGATAATTAGAGATATGCCGGGGGAGAACACTACTCTCCAAT +TATATTTCGGTTGCTCGAGAAATATTTTTAATGATAAATACTGGATACTA +GATTCTATAGAAAACTAATTTATTTCAATAAATTTATTATTATTCAGGAG +AATTATATTTTCTTGCTCGAAAGAAAATAAATAATCAAAAACCGACGCAT +TTTCCTGAATTTATAGTTATTCAGAAGAATATAGATTTTTATTTTCAAAT +TCTGAGAATTCAGAAAACATGGCTATTTGCCGGCCTAGAAAATAGAACAA +CTAGGCCACCGATCATTTTTGTTTTGCCGTTGTCAGGCTTCTGGCCTAAC +TTTCTCTATCTTAAAAGATTCCCAAATTCAAACTACTGGCTTTCCAAAAC +CTTCAAATTGTGGAATGAACTTGTGATTCCAAAGATCTGATGTCAAGAAT +TCAGTCCATAGTTCATATACTCCAACAACACTTTTGGAATTTTAAATCTT +CATGGTTTTCAAAAAGAATCCACCAAATTATTTAGCAACGGGGTTTTCCC +TTCTAAACAATTGTGTGACACAAATCATAATCTCCGTCACTTTGTACAAT +TTTTCTAGTTTTGGTGATTTCCCCTCATGAGCTCAACGCGGCGGAGTAGA +TCTTCCATGCAGGCGTTAAAACGCCTGCCTGCCTGACTTTAAGGCGGCCT +CCGCCTGCCTAACGCTTCAGTCCTAGTCTTGTGCTAAACCATACATGAAC +TATTTTTCTAATTCTTAATTTGGTTCTCATAAAATTGATAAAAATTAGGA +AAATTTGAAATCTGAAATTTCAAGTAAAAATGGGCGGCAAACTTTGTATA +AAAAAAAAAAGAAAGCTCGGCCACCAATTTTTCAAAGTTTCTTACCGCTC +TCTGTCTTGCCTCGGGCAAGCCCTAAAACTTTAGAAAACATCCCCGAACA +AAAAAGTAATAAATCCTTCAAATGTGGGAGATGCCCCGTGTATATGTCAC +CTGTCGACTCGTCGAAAACGTTTGTGCCACCCGGCTCTTTACCTCGTCTC +CTCTTACTCATCATTTTACTGCCCCCGTTGCTTTCCGGCTAATGAGGTTC +TTAGGGCGTAGGACGCCATTGATTTGTGCTCTTTTCAGGCAAAATTTTAG +ATTTTATTTCTCTGATTTCACTCAATTATCAGACAATCTAAGTTTTTTGA +CATGTTCAATGCTGGAAGCAATTTTCGATTTTTTTATCGACCATGGCCTA +AAATTACGGGTCAATTTCCTGAAACGGACGAACATTTTTGAAAGCAAAAC +AGTTTGTAGAGTTTCGCTAAAATTTCTGATTTTTATCGAAAAAATCGGGC +ACACCAAACAAAAGTTCGTTTGTGTCAGGACCTTGACGGTACGCAATTTT +CGGACAAACCACGTGTGGCTGATTCAAAAATGTCAACTAAATTGACATCT +TGAAAACATTTTTTTCACCTGAAAACCACTAACAGTGTCAGGTTAATCCG +ATTCAAGCGCTATTTTTATGAACTTTCCTGAAAGTTTAATTCCACACGTT +GTGAGGGAATTTGACACATTTTTAGAAAACCTGATCTCACGGTTAATTTT +TAAACACTTCGAGGGCCCAGAAATCCTAGTTTTTTTTCTGGTTATTCATA +GTTTTTCTAGAATTTAATTTCACATCTACATTTCTAAACAAAACTTTTGA +AGGTCCTTGTAATTCTTCTCTAGTTTTTTATTGTCAAATTAAGTTTTCTC +CAAATTAGGAAGAAGCGATAATTGCGGGTTTTGTGAGGGAAGTTTGTCGT +CGGTCCATTTGTTTTGAAATGAGAATCGGAACGATTTCCTGTCTCCCGTA +GAAACCAATTAAACGAAAACTTTTTTTTTTCATTTCGTTCATTTTGCATG +CTTGCTAGCCTCGTCTATTGGAATTCTTTTGTACTATGATTCTATTCTAG +TTGTGTCTGCATTAAAAAAATCGATTTTTTTGTTGAGTATATTTATTTTT +CAAACAAGCCGAAAAAATAGATCAAAACTGAAAATTTTATAAGAAAAATT +TCAGTTTAAATCTAGTTTTTTTTTCAATTGGCCAACTTATAATTTATATA +TACTCTCAAAATCAAAAAAAAATGCACATTCTATATTACCCACAAACATC +GAAAATCCGCTATTCCCTCAATTATAAAAAATGTGAGAAAATCCTCGATT +CTTGGTTGCTATGAGACAGATTTCAGATTTTTCACCGGATAAACAAGACG +TTATCATTACTTTTCAGTAATGCGCGTTTATTTTTCTATTCCATTTTTCG +AATTTTGAGATGTTGTATTATTTAGAGAGCACGAAATTCTAAGAATGCGT +ATTGCGCAACATATTTGAGGCACAAAATATCTCACAGCGAAAACTACAGT +AATCCTTTAAATGGCTACTGTAGCGCTTGTGTCGATTTATGTAAATCATA +TATTCGTCGATATAATATTGAGCGAAAATTAAGAAAATAATACGAAAAGC +GAAAAATTAATATCGAAAATCGAGATTCCGTAAATCGACACAAGCGCTAC +AGTAGTCATGTAAAGAATTACTGTAGTTTTTGCTACGAGATATTTTGCGC +GTCTAATATGTTGTGCAATACGCATTCTTAGAGTTTTGTGCCTCCCGTAA +TATTATGTACAATGCGTATTTCCTCTGCATGCAAGACTAATTTCCGATTG +GTCTGTAGAGGTGCAGTTGGCTGGCTGACTTTTAATACTTATGTTCCTTT +AAATTTTCAAGTACGATTAGGAACCCTTTCTCTCAGAATTTCACTAGTGT +ACCTTAATGTTTGTCTTTTGCTACCTGAGACGATCATCAAGTCTTTTCTT +TTGTTTGTATTAGATTTCGCAGTAAAATTGTGAAAAAAATTGCAAAAAAT +TGAGAGCAAGAGCAGAAATGTGCACTTCTCGTTGTACCACGATTTTTCGT +TTTCCCACTAAATACCTATACGTATAGGATTATCCAAAGATGATCCCGGG +GATCACCAGTTCTTAGTTTCCTTATCAATTTTATATTACTCGTATGCCTT +CCTCGTTTTTTTTTCTAAAGCCATGAAAATCATAGGTATCGCCTCAGCGG +GTCGTAGAAGGAGCACAATGTACTCGAGCTCGTCACGAAGACCGTTTCGA +CGGCTGGTTCCGCTTAAAATGGTTAGAGAACTGGGTCTTGATGCGATCCT +AACAAATTTTTTGAATCTCTAAATAGTCCCTATAGATCATGTAATAATAT +AGGTTGAACGTTTTACAGAATAAAGTTTTACAATAAACTTTATAGCATGG +GTGTGTGGCAAATTTGCCGGACTTGCCGTTTTCCGAGATCGGCAAATTTG +CCGAGTTTGCTGCACACATGAAAAATTTTTAATTAAGATTTTGTGCAAAA +ACTAATGTAGCCCCTGGTTTACACCTTTTTACGATATTCTGAGTACATTC +GAAAAGGATGTTTTAAATAGATTGAATATCAAATCAAAAAAGAAAGTTGC +ATGAGTATTATATCTAAAAACTTTTAAAGAACACATTTTCAGGCACAAGG +CCGAACGGCAACCGACTACGCGGGTCAGGACTACGATGAATGTTATGATA +GGTTAGTTTCTTTTTCTATTATTTCATTCAGAATATTACGAATTAATGCT +TAAAAAATTTTCAAATTAATTTTCAAATCAACCGCCTTAGCTCCACCCAG +CTCTCTAGATCGCAACCCGCAATAAAGCCCATAAATCAGTGGGCAGCTGC +TGCTGCTCCGTAGTGGATCAGTCTGTCGTCTCTCCGATCAGTGCGCTCTC +GATGATACTCTCACATTTGACCTTTCTCGCTTTTTGTAAACTATGTGCTG +GACACGTTGAAAGTAGTATCAATTGCACTTTTCTGGGTAGTTACCGATAA +AATTGCCCAGATGGAAGAGTTTTCCATAACAATTTCTCTTCCATTTTCAT +CTATCAGCTCTGTGGCCCCGCTCATTAGTGTTTCTCTAGCCGATGCTGTT +CCAGGTTCCCATGGCAATGTGTACATGTGTGCCTAAAGTGAGCCAAAATG +CTCTTTGAATTATTCATTCATCCTATGTTTTTTATTCGTCCTCACGTGAC +CTGCACCACACTGCGCATTAAATATTAATTGGCACTGAAGAGAGCCGCCG +CTCGGGCAAATGTTTAAATTTTAAATTTAATTGATTTATACATATTTGAA +AAATGAGACACTATGTTATTTTCGCCGAATTCGTTCTCTGAGCATTGCGT +TCATATCTTTGCACCTATATGAACAATTAAAATAATTTGTGTGTCCGGTA +ACGAAAAACCCGAAATAAGTCTTGCCTATACAGGAGTTTGTGGAAAGTTT +TCAAAATTTTTAATGCAAACAACGAAGGAAATTGGAGACGTAATACGATC +ACTAGCAATCTGAATTTCTACTTTCAAAACGTTTTTTTCATAAGAAACTC +CATTATCCAAAATCCGGCCACCTTGCTAATCCTGAGTCCATAATAGGCAT +TGCTAAGGCAAATCTAGGGCTTTTGGCCGATAAAAGACTTTTTGATAATA +ATTTCCAAGCTTAAACCTTATTCATATTACTTTTAGTAATCCTATAAGTT +TTGTTTGCAGTGGTTCAGAATTGCCGAACATTCCAAGTTTTTTGATAAAG +GTTTTACATATATGTTGAGCTTAAAAAATAAACTCAAAAAAATTAACAAT +TAGTTCATACGTTATTAATTTCAACGAGTTTTAGTGTAAATATATATGTG +GTCCTCTATATATTTTCCGTATTATTATTATTATTGATTCGCTCCAAAGC +TTTAATTTCAGTCTCAAGACTATACTGCTCAACTGTGTTTATAGTAGTAT +TTTCAAACGAACAAAAAGTGACAATACAGTATACTTTAAACTAAAAAAAA +CTTTGTCGATGAAAGTCTATCGATCAAACTAGCGAAATCCGCCCGTTTAA +TCCGTTTTCCCGCCACCATCACTTATTGTGTTTTCATAGAGCTTTATTTG +ACGGAATTTCCTTTCTTCTGATTTTTCATATTTAACCAAAACTTACTTGA +AAGAATCTTAAAAGGGATTTTTACAACTCTCTGGATCAGATTTTTCGAAT +TGTTTCATTCGCAAAAGAAGAGCGACTCACTGCTATAAATGCAACATTCA +CCACACTATCTCCACAATTTCATCTATTAATTCATACAATGACACTACAA +TAATCCCCACTTGCTCAGAATTTGTCTCTCCCGCGGGGGACAAATTGGAA +TCAATCATTCTGTCGGTCGACCATTGAACCACCACCACACAATATGGTTC +AGCGGGGGGAGGTCCAGTTTTATTGTTATTACGTATACTGCTAGGGGAAC +CCAATTTTCGGACCCCGCGCGGAATATTCAAATTGGAAAGAGTGTGTGTG +CAAAAACTTTGTCCATCTTGTGTCCAGCAGACCAGCCAGCAGCTTCTCAA +TTTCCGCTTCAACTTTCTCCACTTTCCCATGGGACAAACCTTTTGTCTTT +CTTCTGGCTTCTCCTCTTACTTCTTATTCTTCTTCGTTGCCCAAATTGTG +CTGGAAGAACTAGAGATGCTGAAAAGAAATAGGAAAAGAGCACGAAGACA +ATATTTATGTTTTGTTTTCCATGGTTCGCCTCGAGTATTTGATTAGGCTT +CTCCTTGTTGTCTTCACTCGACGTCGTGTTCTCTATTTTATGTCCACTCT +TGAATTCCTGGAGTTTTCAGTGCACGCATTTGTTGAGCTGTAAGAAAGCT +GCAGGAGTTTCCCAGAATTTGATCGATTTACGGAGCGGAGTGTCGTACTA +CTTATTTCCGGATTATAAAATTCTGAGAATGCGTATTGCACACCATATTT +GACGCGCAAATTATCTCATAGCGAAAACTACAGTAATTTTTACGTTTCGA +GAATCGAGCCCCCCTAAATCTACACAAGAGCTACAGTAGTAATTTAAAGA +ATTACATTTCCGAACCTTTCTCATTTTTCAACAATTTTTTAACTTGCCTA +GCGTAGCCGAAAATTAGCGGTAATCGCTTCAAGACCCAAAACAAGCCAAT +TTCATCAAATTTCAAGTAGAATTTTGTGAAAACAACCGTCACTACCATTC +TGATGACCCTTTACTTCGACCGCCCAGTTCGTTAAACATTTTTGAATTTT +GTTCACCTGTCTGCCACCACATATCTTTCTTCATCAAAATTCAACGTGCT +GCGATCATCATCTTCATCTCTGTCTCTTCATCTCGCCCAAATTCATTTCC +GTCACTGCGTCTCGTACTGATTTTTTTTCATTTGTCTCCAATCATTTAGA +GGCCAAAAGACCTCCTCTCAATTTTTTTCTGTCTGTCATTGACCCCTCAG +TTGCGAACCGATTCAGAGTTTACATAAACAAGCTCGCTTTGTATATAATG +TTGAGTGAGCGAGAGAGTGAAAGAGAGAAGACGCAGGAAGCTAAGCGTTT +CCTTTGTTTCAAGCTCTGTCAAATTGTCAATTTTCTAGCTAGAAGATTCT +TATGAAGTTTTGAACATTCTAGATTTAGTTTGTTACCTACAACAGGTGAA +TTTGTCTTTCTTGTCCAGAGATAAAACTTATCGTGGCCTTTTCCGAAATA +GTATCAGATTTCCTTTGTACAAGGGCTTTCGTGAGGCGGTAAATCGCCTG +CCTGACTTTAAGGTGACCTCCGCCTGCCTCTCGCCTCAATACGTTATGCT +AAAACAAACGTGAACTTTTAAAAAAATTTAATTTTCAACAAATTGATAAA +AATTTAAAAAATTTGAAATTTACCTGCCTACCATAGAAGCCCTACCTTGT +TCCACTATTGATGCGATTCATTCTATTACAAATCAATGTAACGAACTCCG +AAGTTTGATAGCCCGAGGCGTTTTCCTTGTTAATTTGATATCGATTATCA +GTTTGACCAACCAAACACCATCGATTTGGCTTGATTTTCAAGGAATTTAT +AGAATTTCGTAGAGTTTTGGACTATGTTTTGCATTTACGTTGAATGGAGA +GAATTATATTTGAATAATTGAATAACTTGTTAATGGTTCAAGGATTACCC +GTTCCGAAGTCTAGAAATGCCCTGGCGATGCTCCCGTCGAGAACTGTAAC +CGATAATCAATCAATATTGCGGGTATTAATTGGCTAATATTCATAATCCT +GAAAAGTTATTTGAATAACGGCAAACTCCCAAGAAACATACCATTTCCGA +GGTGTATGAGAATTTTAACAAGACCTTAGGGTACATAAGCCTATCAGTTT +GAAAAACAATGTCGGAATTTGTGCTTCCATGGTAGACAGGCGCGGTTTCA +GGGTCTGAAGCTTGCCTGAAGGCCAGGCAGACAGGCGTTTTAATTCCTAC +ATGGAAGCCCTAGAATACAGCATATACGGTACCTAAGCCAATTATCAAAT +TTTACTTTTAAAAATTCATTCCACAGGTGTTCCTGTTCTGCTGCATCATC +GTCACACAGACACTTACACGCGCCTTTTCACTTCTCATTTCCCACTTTTT +CTTCGTTTTTCTCGCTTTTTCTTCTTCTCGACACGAAGAAGTAGGATAGA +TCTAGAGACGTCGAAAGCCATAATTGTTTCCGTCGGCGTCTCCACGCGCA +CTCGTACTGTCTACAAGTGCCACACACACACTTGAAGAAAATAGAGAGAG +GTGCAGGAGGAAAAGGAGGGGACGACTTCTGAAAGTGTCGATAACTACCT +CCTATTTGAGTAAAGAGTGCAAGAAATATATGTGCGTGTGTGTCTAATGA +GAGGGTCTTGGAGCGATTTTTAAGCATGTACAGGCATGAATCAGGCGGCA +GGTTCCAGCCAGGCTCTGAAACCGCGCCTGCATACCAGGGAAACCCAACG +ATGGTTTTTCTTTGCCCGGTTGATCCCTTTCTTGGATAGTTTTAGTCTTC +GTCCGTTTTTCATTCATACTCTTTTTGTAACTGTTCAAAAGTCTAGTTTC +ATATAATCAGAAATTCGAGAAAAAGGATTTTTCGAGGCTCTGAAAAAAGA +TCCCAGAAGATTGTGTCTAATTCTAATTCTCTACAGAAAATGCCCAAATC +GAAAATTTTTCGACAGATCCTCGTATTTCGAAATTCTGGAACATTCGGCA +AAGCTGAAAATGTCACAACTTGCCAAAATGAACATTTTCGGCAAATCGGC +CAATAGCTGTATTTTTCAAACTTTCGGTAAACCGGCAGTTCGCCAAAAAA +AATTCGGCCATGGTCTAGACTCTAGAGTTGGGCGGCAGACAATTATTTCG +GGCAAACGCAAAAATTAAAAATGGAAATTGGTGTTCGGCAAATCGACAAT +TCGCCGGAATTGAGAGTTTCCTGCAAATTCGGCAAACCGGCAATTTGCCG +AAGGGCAACTTCTCCGAACTGACACCCCTTCCAAAAATCCGAAATTTTTT +TAGCTTCACCCCCTTCCCTCCCTTCTCGTTTTCTAAAAACCGGACACACC +TCTTACAATTATTACAAACACCACTACGTACGTATTAAACGTCTCTCGTA +ATAAGTGGGGCGCCAAAATATAATGGTTTTTGTTGTGTTTAGTTAGCCTC +CTCCTCTCTACTTCTCCACCATCATCAAATCTACCACCACAATAACATTA +ATTCGATCATCAACTGACTACTTTTGTCTTTCAATGTGGATTTGTAGTTG +TTGGTTATTTGAATTCTTAACTATATATCCATCCCTATGTTGAAAATTTG +AAATTTTTGGTAAATTTGAAAGATACCAAGTTTATGTATATTATAATATA +TTATAAAAATTTCCGGTAAATTGATATCCTGCAAACGGCAAACCGACAAT +TTGCCGGAATTGAAAATTTCCGGCAAACCGCAATTTGCCGATAATAAATT +TGCCTTTATTGATTCTAGGTTTCGAAAAATTACGTGTTCCGTTTTTTTTT +TGAATATTAAAATAGGAATATCAGAATTTTTTATTTTTTATTCTGCAACT +TTTCAAATTATGTTCAAATTTATTATAAAACTATCGTAAGTGTGAATTTG +CAATTAATTTTCTTATTGCTAGGTATCAGTTTTACTAGGGCTGTCATGTA +TGTACCAAAACGCCTACCGCGCCTTCTGTCTAGTGCGGTGCGGAACCCGA +AAAGTGTCGGAATCATCTTTCGCAGTATGTGGTGCTGAAACCAAGCCTTT +GAGTTCTCGCCATAGTGCGGCGAGAGGCCGGCATGAGGCGGGCAGGTAGG +AGGCAGGCTTCAGGAACTGTGTCGCGTCTGCCTCCCAATCCCAGAATACT +TTTTTTTTCAAAAAGTTGCAATGGAAATCAGATTTTCAAACGCAACCTGT +CTTCCTCTTGTACTCAACTTTTACTTGATGATAGTCGATAAAGGTGTGAA +CGCGGTGAGGTGTAACCGTGTGACAATACATCATTGTATTATTCTTTTTC +GCAAAAAAAAAACATTCTTTTGGGTATTATATTCTACCAATGTATCTTTC +ATTTTCTCGATTGATTTTTTCTCCGGCGAAAAGAAAACAAATTGAAAAAA +AACGTCAAAACATAAACATTTGGAAAATATAAAGGTGGATATAAAAACGG +TTTCTTTCTTCTGGAACATTCATTTTTAACCATTTTCCTACATATTTTCA +CGCTAAGCCGGAGCAAAACAGAGACAGTCGAGACTGTCAAAACATGTAAA +ATATACGTTTTTTGGTATACCTATTTATTAACAGGTGCTCCCTTTTCTCT +AAAAGTTTAAATTTGTCGCGAAAAAATGCAAGAAATGTTTTTTTTCTAAA +AACTAAAAACTCGATCAAAAATAATAATTGGGTATTTAAATATTCCGGAA +TCTCCATTTTCTTCCCGTTCCTGCCCTTCCATTTTTTTCTTCCTGCACTT +ACTCGAGTATTCATCCTCTTCTACTGCTGCCATAAAAGGTCTTCCGCTTC +ACTGAAGCCTTCTGCACAGCAGCGTATCCTCCCGCTTCATATCTCGTTGC +TGAACTCCATATAGCTTGTTATAGCTCAGTTTTAGACGGATTTAGGTTCG +AATTTCTGTAGGGTCTCTAGGAGTACTGTAATAAGTGATGTGTCAAAAAT +TTGGCCTAAACTGTCATTGCTATAGATTACGGTGATAGAAATTTGAATAT +GTATGAAATAGTGAAAAATCAGTAGACTGAGCCTTACTCAAATTCACATC +CGTTCGAGATATTTCTGAGTTCTGAATTTCTGTTGATTGCAATTGCCGTA +ACTTATAGCAAGGAAAGAACAATTTGAAGCCGAATTTACGGCACAAAATT +AGTTTTGGTGCTTCTAGAGCCTATTTTATAAAATATATACTTGACACGTG +GCTTTTCAATATCACCATCTCAAGAAATTACCACAATCGTTTCAGGTGCG +AACAAGAGTGTGGCGAGGAGGCGTGGCGAATCGCGTGCTGCTCACGAGTC +GGGAAGATCGCCATCCTTGTCATGTCAATCATTGTATTATATCTTATCAT +ATCAGGTTGGTTTAAATACATATTATTCAAATTTATCTGAGTTTACACAA +TGAATTTTCAGCATTAACGCCCTCCGAAAGCACACACAAGACGGACCTCA +ACGAGCCGCGGCCTGGTATTAATTTAACAAGGTGAGAATGTTGGGAACAT +ATTACTATTGTAGGAAATTGCTCGATAATTCCACACTTATTGAGTTCACA +ATTAATTTCTACTATATTAACTGTGTTTTTGGTAAAGAAGTATCACTTTT +TCCCCTCCCAACTCCGATAATTCGGCATTCCTAGAGTTTTAACACAATGT +TTTACGACATACTTATGAAGAGTTGATGCAAATCGCAAAAAAAAAACAGA +AAAATAACTATTTTATGAATAGTATCATTATCGTATGGTGTCGTCAAAAT +GTTTTGTTGTTTTAGTTTTTTTTTACTCGAAATTTTCTGAAAACACCGAA +TTTCATATTGAATCAAATTTCTTGATAATTTATTAGACATTTCGATTTTA +CAGAGCCAATCAAGTACTCACCGGATTATGTGATGCCTATGAGCGAGGAG +ACGTTTCCGGAGACTCTTGTAATCGACTTTGCTATGATCGAAACTGGCTT +GTCACTGACTTTTACGAAGGGCACAAGACTGTGGTCATAGTGAAAGATGG +CGGACAGATTGCTGTCTATAAAAGCACAAAACCGTTTATGGATCAATTCG +ACGAGCCGAAAGACCATCTGACGGATGCAGAGTTCTCGGATCGAGTAGTC +GATATGGTGAATGATGAGCTGAGACTCGGATGGCCGAAACACTATCGACG +GCATTTAATGGAGACTGTGTGGCCGACACTGTTACGGACCAAGGGAGAAG +CCATGTCGAAAGCGGATCGACGATCCTTGTGGGCTTTGTTAAAGCAGCCT +GAATTCATCCTGTTCCGAGTGTTACCGTTGACACGTGTCACGCCGAAGCT +CATTGGGACGTGTGGACATATGTATCAGACTGAGTCACTGGTGGCGTTCA +AGATGAAAGGGTATTATACGAATTTGAAGGTGGGGATTTTTTTTTAACTT +GATTTTAAAAAAAAAATTTTCTCAATCCAAATTTACAGGCAAAAATCTTG +GTGCATGTCATGGGAACCCTGAAGCTCTTATACGAATTTCTCGACGAACC +CCTTCAATGGTGTGATGTTCGATTTGATAATCTCGGGTTATCAGCAGATT +ATCCGAAAAGGTAGGTCTGCCTGTTTTTTTATTTGATTTTTTTTTCCGAA +AAAATCTACATTTTCAATTATTCGAAACGTAATTCGAATAAAAGTTATTA +ATGATTTTTTAAACAAAAAAATTGATGATAATCCAACCGGAAACTCAAAT +TTTGAAAACCCCTAAAAATCCAAATTTCTCAATTTTTCTGCAGATTCGCT +CTAATGGACGGTGACATGGTGTACACGAAATCGAAATTGGATTCTCTCCT +AAAAGGACGTCCGTGTGAAAGTGATAATGATTGTAAAATTGGAGACTGTG +AGGCGAGATGCACTTCTAATATGGTGTGCTCGTCGAGGAGTAACGGGAAT +TTGGAGGTAAGCTTGAAAGTTGAAAAAGTTTGGAAAAATTGTGAAAAATC +AATAAAATCGGCAAAAAACGAGCTTTTTTCCAGATGGCCGAATTTTTCAT +AGTTTGCAAAAGTTCGTCCACCTGTGAAAAATTGCTAAAAAAGCAACAGC +ATTGATGAATATTCATAAAAAACCAATAAATTCGACAAAAACCTTTTTGA +TTTTTCCAAAAATCGAAAATCACATTCTGATGTTCAAATTGAATTTTCAA +AAAAAATATAGAAATTTCCTAAAAGTTTTAATTCTCAAAAAACGAACGAC +TGACAAAAAATTTTTAAAAAAGTGAATTTTCCGAATTTTTTCTAAAGAAA +AACTGAAAATTTGAGAATTTTCAGTCAGAAATGTGATTTTTTTTTTGATT +GAAAGGAGTTTATTTTGTAGAATTTAACTTCCACTATCAGAAAAAAATTT +ACCTATTTACTTTGTAATAGGAAAAAAGTTGTGAAATTGTTAGGAAAATT +TTTTTCAACTTTACAATTTCCCGGACAGGCCTGTAGTTCCTTTTTTTCAA +AACGTAAAAGAAAAAATTAATTAAAAAGTTCAAACTCCTAGAATTTATAC +ATTTATTTTGCATTCTAAAAAACAAAGTTTTTCTTGATTTTTTTGTGTAA +AAATTGAAAAAAAATCCAAATTTTGTAGGTCTTCTGCGATAAACTGGTCA +ACAAACTGTTCGCAAATCAATGGTCCAAAAATAATAAATATTTGGTCGCA +TGCCGGGATACAGGACGAAATATCACAACTCGACTCAACGAATTACGGTT +AACATGGTCATGGAATCTGCCGGATGTTTAAAGGAATCTAGCTCAATTCT +TTCTTTTTTTTTCTTCTACTCCATGTGTCAAAAAATCCCCGTGTCTTATA +ATTTTCTGGTGCTTTTTTCCATATTTTCCTTTTTTTGTGTTCTGGCTCAT +TTTTCCATGGCTCACAGAGCCCGAAAGCTTAGGATTTTGAAATTTTATTC +GTTTTTTTCTCATAATTCTGTCATCATTTTTTGCTCTGCATCATCATCAT +CATCGTCAACATCATCGCGTTTTATTATGGGTTCATGTATTATTACACTT +TCCTCGAAAAAAAATTTTGACGAACGTGTAATATGTTTCACCTTGTCTCA +TTTGTACCTCGTTCATTGTTACGGGTTTGAAGTTTTAAAACTCTGAATTT +ATATGAAGAATTTTAATTTAAAAAAAAACTTTGTTTCCTTTTTTGAATTT +TTACAGACAAATTTTTGGCTTGAAAACTGAAAAACCCTGACTAAACTTAC +TATTTATGTGTTGGGTATCAACGTGTATTGACCCACGACGTGGCTAAGAA +GATCGTACAACGTGAACTCTATGAACTAACTTATTTATTCCTTAGTTTAG +TAATGTAATAAACTACTCGTCTTCTCCTCCTCGTCTCGCCTTCGAATACA +CAACATTATGAAAAGAGTTTTTCTTAAGATAAAAAATGTTCTAAAAAATC +GATGGCCGAGTTTCCTATTTACGCGGCCACAAGACCAGTAAAAAAGTGTT +AACACAAGTGCGAAAACTAGAACATTTATTTTCAAATTTCACCCGATTTC +TACAAAAAATCAACAAAAAAGTCACAAAATTTAAAATATGAACATAATAA +TCAATATCCCGCTGGCGCTGACTCCTCCCCTTTTCGGAAATCACTGTTCG +CATAGATTTGGCCGTCGGAAAGTCGTTCGGCGGCGGTGACAACTGTCAAA +TTGTTCACTGCCTTCATTACGTGACCACGATCGATCAGGGATTTCACGTA +GGCTTTCGGGAAGTTTGGCTCGTACCACGTGTAATTTGGCTAAAAAATAA +GGAAATTGGGAAAGGTTTTGATTTTATTGATTGAAAAATATTTCATGTGA +AAGTCGAAAATTGATTGAAAATTAAATTCAGAAGTTTTTTTTCTGAAAAT +TATTGATTTTTATTTTTAAAAAATCAACTTTTTGACAATTATCGATTTTT +CCAACAAAAAAAAAATCAAATTTCGCGTGTAATTCTCTACCTGTAACTGA +TTGTGCATCCTTGGAGCATCAACAGCTTGTTTAACATCTGCTTTCAGCCA +TAACGCATGCAGTGCAACTCCAGCAACACCCGAAATAATGGTGGATCCAC +CGGCTCCGCCGACCGCCATAAGCTCCGCCCCTTTTGTGTTAAAGATCACT +AATGGACTTTGACTACTCATGGGGCGTTTTCCAGGGCGAATGAAATTGGC +GGGAGACGGTGGGAAACCGAAGAAATTCGGATGACCGGGAGTGGAAAAGT +CGTCCATTTCGTTATTCCAGAGAATTCCCGTCGATTCGGAGGATACTAGG +GCACCCAGGCTGGAAGAATTTGAGATGGTGGAAGAGTTTTTTTGGCGGTG +GCCTAGAAAATGTCTTCATATCCGAAAAAGTCAAAGTGATGGCCTAGAAA +TTTAAGTTTGTGGCCTATAAACTTGAACTGATGGCCTAAAAATTGAACGT +CGTCCTAAAAATGTTTTTAACTGATGGCCTAGAATTGAAAGGTGATGGCC +TCCAAATTTCAGGTGGGCGTATATAAACTTTGGTTGATGGTCTAGAAATT +ATACACGTGGCCCAGATTATGAAATCACTTCGGTATAAAATCCAGGTGGT +AAACAATTTACTATTAAGACTGCCTAAAATCATCCCCTGGCCTAATTAGT +TTAAAATTTTTGGTGACGACCTCGAACTTGTTCATTTTTATCAACTGCAG +TTGCTTGTCGACTGAGGACTAACTTCTCACTTGCTGGCCGAGTTTTCGAA +GTTCGGCCACCAAAAATTTCCTTTAAAAAAGCCAAACTCACTATAAGTTA +ATGGTAGACGTAACCGAAACTGCATTGCCGTCTGCATCGATAATCGATAC +ATGAGTTGTTCCATGATCCTGCGGTGGTGCTTCAAACGATCCTCCATAGT +AATCATCAGGATGCGTCGTGTCTGTGATCTTCGACCTAACCCAATCCGCC +CACTCTTTTGACGTAATATTTTTGGCGATTTCCGTGGCGTTTGCCACGAA +TTGCGGGTCGCCAAGCCAGCTTCTAGCCGCATAACTAAATTTGCTAGATT +CCAGAAAATGATGGTATAACGTTGCGATTTCGTTGAACGACTTCATGTTA +TATTCGAAGCCATCCATCACGTTAAGTATTGCCTGAGCCACCGCTGAGCC +CGAGGGAGGCGGCGGGCCGCAGACTCCGCGCCCGTTTTTCAGCTTTGTGT +AGATCACATTTTTTGAGTCGTGGACTATTGATTTGTAATTTTTAAAGTCC +TGAAGCCGGATGATCCCACCGTTGGCTTCGAACTCTTTGGCGAGTTGCTC +GGCGAGCCGACCTGTATAAAAGTCGGCGATGGGATCTGTGGAGTTTGCGA +GTAGCCGGAATGTTTCTAGAAGGTTTTGGCGGGTTTTTATCTGCTCTCCT +GGTTGGAAGACACGCTGAGTTTCGGGGTTGATGAAGTTTTTCATGGTGGG +CTCCGCGCGGATTTGGTGCTCGTTTTGGTTGAGAGCTTTTGCAAGGGCAT +GGGACGTTGGGTAGCCTGGAATTTTTTAGGATGGCCTAGAAACATGAACC +GATAACATAGTTACTTATTTTGTGACCTCGAAATTTTCATGATGGCTTAG +AAATTTTTATGATGGCCTAGAATTTTTATGGTGACCTAGAAATTTTTTGA +TGGTCTAGAAATTTTTAGTAATGTAATAAACTACTCGTCTTCTCCTCCTG +AAAAAATTTGGGCCCGTCTCCCTTCGTGGTGAGACCCATCGTGGCGAGAC +CCATCGTGGCGAGACCCATCGTGACGAGACCCATCGTGACGAGGCCTATC +GTGGTGAGACCCATCGTGGCGAGACCCTCCGTTGAGAGACCCATCGTGAT +GAGACCCATCGTGGTGAGACACGCCGTGGTGAGACTTATTGTGATACCCA +TCTTAACGTACACAGTAATTGGAGAAACTTTTAAACTGATTTTTACAAAA +AGTTCAACATTTAACTTACCAAGAGCTCAATATTCCGTTGCCTCGCTTTT +TGTTGCCCTCAGGGATTATTGTTCTGTTGCCTCCATTTCCGTTACCCCTG +TTGTGTTGCCTTCGAGCAGCGTTGAATCCGTTGCCCCCCCCCTTTTTCGT +TGTCCCCGGGGAATATTAAATCCGTTGCCCCCGTTATCCGTTACCCCTAG +GGATTGTTGGCCGGTCTAAAAACGGCCACCAGAAAAGTTTTTGAGCATCA +AAAATGTTCTACGCCGTTAGGAGTTTTTTAGGCCAACAGAAATATTCTAG +GCTCGCAGAAAAAGTGCCCACCTTCAGCCAACAAATCAATAGTTGGTTTC +AACAACTGTCTCCACTCGACTTTTCCACTTCCGAATCTCTCGAATTCAGT +CCGGAGGCCGTGAAGCTCTCCGGGCACCGCAATCGCCTTCCATCCGATTC +TCGACTGATTCCATTTGTCACGGTACATTTCCTCTGTTGCGGCGAGCGGA +GCAATCTCCCGAGCATCGATTACCGTACACTCTTTTGTCGTTCTGGAAGA +ATTTTAGAGGTTTCTAAGTCATTGAAAATATTTTTAGGCCACGGCAGAAG +TTTAAAGGCCACACGCGCTTCTGGCTTTCCTCATATTTTGAAATGGAAGA +GTTTGCCGAGTTAGCCCGTTTGGACTAGGCCACGACCGGGGTAAATTTAC +GGAGCGTCGTGTAGACGATTGTCAATGGAGCGCGAGAAAAACGCTTTGAC +GAAGGCCAGAAACCAGTGAGGCCACAATGTGATGTTTGCAAAAATGTTTT +TAATGGCCTAGGAAAATCATTCTTTCTTCCAAAATTTTTCTTCTTTGTTT +TCCTTTTCGATTATTGATTTTTAGTTGAAAAATCAATATTAATAATTATC +TTTTTTTTTAATTATTGATGTTCCGCTCCAATTCGTGGCGAGACCAACAA +CTCACGCATTATAAATAGTCATAAAATGTCCGCCGCCAATTCCGGCCGAA +TGTGTATCCATTACACCGATACAGAAAAGTGCGGCGATTGCCGAATCCAC +CGCATTTCCGCCTTTCAGCAAAATATTCCGACCGATTTCTGAGCAAATTT +CGTTGTCGGCGGCGACGGCGGCTTTCGAATATTTTCCGAGTGGAGAAAGT +GATGGTCCAGGCCAACGGGGTAGGCGGGCATTGTTCTGGAAACCTTGCCG +AGTTTTATTTTTATCGGCCACGTAGCAAATCGGCCAGCCATGAACCGACT +GCGGACTAGTTTTCACCCTCGTGGCCTAGCTTTCTAACAAACCTGCATTA +GTAAATGAAAATACAATGAAGCGAATGCGACCGTTGAGATTAACAACGTG +AATACGAGAACCGTTAAGCCGACCGCCGCGACTAAAGTACGGATTTTCAT +GGGTTGCTCGGCCTCGATAAGCGGCTCAACTTCATCAAATGGTCCATATT +CTGGCGGTAAATTATCATCGTCCGGAAACGTGTTATAGTATTGAACAGGA +GGTGGGTTACTGCTGAAAAGTCGAGTTTTGCGCGTCAAATTTGATGTATT +GAGTGGCATGATCACTATTATTACAAGACCGCGAAATTTTGAGAATGCGT +ATTGCACAACATTTTTGACGCGCAGAATATCTCGTAGCGAAAACTACAGT +AACTCTTTAAATCACTACGGTAAAGCTTGTGTCGATTTACGGGGTTTCGG +TTTTTTCATTTTTTTTGTGTTTTTTAAAAAACAATTTATCGACTAATGAA +TGATTTCCGTAAATCGACACAAACACTACAGTAGTCATTTAAAGAATTAT +TGTAGTTTTTGCTACGAGATATTTTGCGCGTCGAATATGTTGCGCAATAC +GCATTCTCAGAATTTTGTGTTGCCGTAATAATTCTGATTTAAAAATGGAA +TTTTCAAAAATCAGAGGTTTCCCAAAAATTTGAATATTCCACAAAAAAGA +TGAATCTGAAGAGTATTTTCAATTTTTTGAGAAAATAATCGATTTTCTGG +ATTAAAAAATTTGAATTTATAGATTTCTAGATTCTAAAATTTGAATTTGT +GCAATTTCAAACAAAAATGTATCGATTTTTATCGACTTTTCATAAAATTT +AATTTAATTTTCGAAATTCCGAAAATATTGCCCGTTTTTCATATACCAAA +AAAGTTGTATCAATTTTTTCAAAAAATTAAATTTTCATCGATAGTTGTTT +TCAAAGCATCATGATTTTTTTGAAAGAATTTGCAAATGTGAGAACTACAG +TACTCCCTTAAAGGCGCACGCTTGTTTTTATTTTTAAAAAATTGGTCGTT +TCGAGACCTGGTACCGTATTTTCGCATTTGGGTAATATTTCCAGCATTAT +AAATTTAAAAACAATGCACTTTTTAAATCTTGAATCCATATATATATTTT +TTTCAGAAACTCATGCCGCCTCGTTTGGGTCTCGATTCGAATTTTTTTCA +CAAACGTATAATATTTTCTCGAAAAACCCGCGAATTTTTAACATTATCGA +TTTTTCTCTCACCTCGTCGATTGCCCTTCAGGAGTCATTATTCAGAATTG +AGTATGAATTAAAAAATCATAGAAAAAGTCAAAGCGCTGTCAATTGGAAA +TTTAGGACGAGAATGTCAAAATTGCAACTTTTCACGATAACGGAATTCTA +TCGCAAAACTAGATAAGAGCTACAGTTTGCTGCGTGTAAGCGCGCTCCAA +TGACAAACGAGAAGAGAAGAGAAGAGGGGGTAACCGCCAATAGCTCTCTT +TATCGAGGATAGTCTTCAAGTGACAGAAGAGATATTCTGTGGTGGGAGAG +AGTTGGGTGGAAGGGGGAACAATGAGGACTACGGAAGAATGACTTTTAGA +TTTGGAGTATAGGAGAAAGTGGAGGTTTTGGCTGAAATTATTTTCAAAAA +CTTTAACTGTAACAACTAACGAGTAGATTTGAAAATGAGGATAATATTCA +ACACAACAGAAAAAAAGTCGATAGGTAACTAATAAAAATTAGAGAAAATG +TGGCATCGGGGAGAAGTGGTGGAACAAAAGAAGAAACTGATGATGATGAT +AGGAGGATAGCCGCGAAACAAGCGATTAACAGTGAACAAGATTCATTTCG +GTGAAGATGGAGAAGATAACAGCAAAAAAAAAAACACAACAAAAGTCCTT +ATTATTGCCCATTGAGAGTTTGTTGAAGGACACTGGTAAGGTGCTCGTCG +ATTCCATCTTGCTGCGCGAATTGTGGGAACGATGCGTAGATTTGCTTCAG +GATTGTGACAATTCTTTGCTTGGTTTGGTTGCCGCTATCGTCGTCGTTGA +AAGCATCGTTGGCGATTGAGAGCAAGCCTGAAAAATACAAATAAAAATAA +AATAAGTTACGGATTTTTTTAGATTAGAACTTACAAACAAGGAAGATTCT +CGGAAGATTCTGATTTTCTGGTCCAAAAAGTGCGGCGTCTTGTTTATCAA +ACAATTCGGCGAGACACGTGTAAATGTAGGGGCTTTCCTCGGTGTCTGAA +TATGTTGGCAACCAGCTCAGGAACATCTCGACGACCTGGAAATAATATGG +AACTTTTTTCTTGAAAAACTGAATTCTAAAACCAACCTTTCCGTAGGCTT +CAGCAGGAAGTGGCACATTGCCGATGATTTTGGCAAATGCAGAAATCGCG +TTTTCCGTGGCAACAGTGCTCTCCTCGGTGGCTCGGGCGTCCTCTCGTTG +AATCATGGCGGCCAGTGGCTCCAAACAGCTCAAAATCTCGTTTCGGTAGT +CGCTGATCTGGTGGTAGTTGATGGCCATAACTCCGAAACCGTAGCTCGCT +GCTTGTCTCACTTCAGGATACTCATCTCCCAACAACTTGTACATTATTGG +AATAAGCTTCGGGAAGCGAGTTGGCATATGTCCGACACCGAACTCGATGG +CGTCATCGAGAAGGCACATTCCCCATTGTCTCTCGAAGTATTGTTTGGAT +CCCTCGATGAGTTGAATGGCACAGTTGAACACGTTGATCATTCCCTCGAA +GATAGTTCCCTTGAACTCCTTCATAAGAGAGTGAGTCAAATCAGAGATGG +CTCCAAGGCATGAGGCCTCCAATTCCATGAAATAATCGAGCTCCTCCTTA +GCTTCAGCATCATCGTCATCTTCATCTTCAACTGGACGATCGCTCATTCT +CTTTCCGTAGTTTTCAAGTTGCTTGAGAAGCACCGAAATGATGAGTTGAA +CCTCTTCCTCGGCGATTCCCTCGGTTTTCATAACCTCAATGCACGATCCG +ATGGTCGTCATGAACGAGGCGAGAATCTCGACATCGTCCTCCTCCTCCAT +AGAGGTCGTCAATGCCTTCAAGAACTCGCACCACAAACGACGCTTGTCAG +CCAATCCTTGCTTCTCAACACAGGTCAACAAGCATGGCATGATTTCAGCG +GAAGCCGTACGAACTCCGTCGTGAAGTCCGAAATCGAGATTCTTGATGGC +GAGCTCGTAGACGTCGACGACGTATGGCATGAAAGCCTCCTTCATCTCCT +TGGCGAACGCGACAAGCATATCGCAAGCAGTTGCCTTCTCCTCAAGACCG +CTGGTGCGGATTCCGACAGTCTTTTCTCCTCCGATTCCGTGGTATTCAAC +TCCTTCCTCGTTTTCGTGAACATCTTCGTCTGAAATTTATATATTTTTTT +AACACGTAAAACTAAAAAACACTCACTGTTGAAGATATTGAAGTCTGGGC +GGTAACGAGCGGCACGAAGAACTGGATCCATGACAACTGGGAGGAATGGT +GCGAAATCGGCTCCAAGAATAGAGCAGAAACGAGTCCATGAGCTGATCAT +GTAGCTGTATTGTGGATCATCGATAGCCAAATCCTTCATTCCGTCTCCGA +GAAGGTTCAGGATCTCGATTGCAGTAGCGTGGAATTGTTCCTTTCCGACA +GCATATCCGATGAGAGAGATGCATTCGATGGTCTTTCCTCTCAACTCCTT +GAGCTCTCCGACGTTTTGAAGAATGTGAACGAGGTTCGGGATGAGGCGAG +CATGATGTTCCTTGAAGAGCTCCTCGGCGGCTTCAGCGACGGAGGCGATG +GCGGTGACGATGTTCTCAACGACAACCTGGTATCTCTTGTCTCCGAGACG +ATTGAACACAGCGGAAAGCACATTTTCGAGTTTCTGAAGAATGAATGGAA +GATATTGTCCAATGATGCTCTTTGGGCACTCCTCGGCAAAGTTGACAAGA +GCCGAAGCGGCATGAGCACAGACACGTGGAACATCGGTTCTGTCAAGAGA +CTCGAGAAGAGCTGGTATGACGGCGGCGTGGCACTTCTTCTGAAGAGTTG +GAGCGAAGTCAGAAGACATTTGTCCGATGGCGTTGCAAGCCGCGTATTGA +ACTCTTGGATGAGCATCATTGACGTAATTGGTGATATGAGCCATAATTTG +CTCTATGTGTGGTTCCATAGATCTTTGGCACCCTTCACCGACGGCGGAGA +ACGCGCGAAGAGCCGCGTGCTTCATCTTCCAGTCTTCGCTGGTCAAAAGC +TTCTCGACAAGTGGAAGGAACACTGGGAGCATCACTTTTCCGTTGATGCA +GCAAGCAACACGGTCGATGGCGCTTTCGGCGATGATTGGGATACTGAAAA +ATAATTTAATTGAAGAAAAACTAAAAATTTATCCTTACTCTTCATAGTCT +TCTTCCTCTTCGATCTCGTTGAGCCACTCATTGAGCACATCGTCATCCAT +TTCGGTCATGCATGAAAGAAGAGTCTCGAGAATTGGTCCAAGAGCTCCTG +GTGCGTATTTCTTGAGTCCTTTTGGTGCGGATTCCATGTACGAGCAAATA +ACTTCGATGGCGTTCTGACGGACCATCTCGTTCTTTTCCTTGTTTCCAGC +AATCTGAAATTTGAAAAAATGAAATTTTTAAATTGGGCCATTTAAATTAC +TTACAGCAAGAGTGACTTGAAGAACCTGAGACATATGAGTGTTAAGGCAT +TTTGGCAGAGAAGAGGCGAGCTCGGCGAACTCTCCGAGTGGTCCATCTGA +ATCATCCTCGTCGCTGGTTTCATTGCAAACTTGAAGAACATTTGGAACAA +GAGAGGTCATAAGCCTGACAACATCCTTCTCCTCATCATTATCAACAGCG +AAAGCGATAACAGCACGGACGGCGGTGGCCTTGATTTGCAAATCCGGTGT +AGCCATGCACTTTTCCAAGACAACTTTGAGGGTTGGAAGGAAGTGGGCCA +GCCTGTTTCCAAAAATTATTGGGCATCCGCGAAGAATAAGCAGGGCTATG +TAGTTTCCGGTAAGATCCTCGCTCTTCAAACAATGATCCATCAGCTCGAG +GACTCCTCCCCATGTCATATCTCCAGAATCGTCGATGAGGTTTGAAGCGA +TTTCAGAGATCAAATCAGCAATCTTCTTCTTAATCGAGAGTTCGGTCTCG +TGAACTATCATCTCGAGAACTTTGGCGAGAATGCGCTGTTTGTTCTCCTC +GTTCAGCGTTTCCCAAATCGCATCCCAGTCTCTGGCGAGAACTCGTCGCA +GAAACACCAAAACTGTGGATCTGGCCTGAAAATCGAAAATTCATGGAATA +TATAGGAATTTGAGTGAACTAACATCAGAATTATTCGTGTGGTGTGTGTA +GGCCTCGAAAAGTGCAGCTACTTTGGTTGGTCCTTCAATCTTTTCATAGA +CTTCTTCAGCTTGTTTTCGGATATCATTGTCTGCTGACTGCAGTTTTGTG +ATGAGCTCAGTGAATTGATTGACGTCCATTGTAGGGAACCCTGAAAATCA +GAATATGTGCTAAAAATTTCAAAATTGAGAAGGAAAAAGATGAAAGCGAG +TCGGTTTTGCAGATAAACGCCTGGGGAATACGCGGAATCGCTGAGGAAAA +TAGATTTTTAGTATAAAAATTGGCATTTTCAACAAAAAACCTATCGGAAA +ATGTGAAAAATAGGCCAACAAATATTGAATTTTGGGACAAAAACGCCTCG +AGTGCACGATTCTCAACGGAGCGCACTTGCTGCGTCACACGCACTTTAAA +CTGTACACGGCGGGAAGTTCAAATTTTAAAAGGATTCACGTGATTTTCAC +GACATTTACTGGTTTTTTCAGCGAGTTTTCGCAACTTTTCGGCGACAACC +GATGATGATTTATGTTTGGAATATGATGATGGTAGCGTGTTGCGAAATAA +AAAATCGATGGAATGAGTCAGCGAGAAACTAATATTTGCATAGAGAACTG +TTTGCAATTTTGGCATTACATTGGCCAGTGCACTGACAAAAAAAGAAAAA +AATAAACGGCAAAATCTCTAATACCTATTCCAGGCAACCAGTGTCTGGCG +ACGATGGAGAGTAATTCTGAAAGAGACGCAGTTGAAAAGAGTGTGTTTTT +CGCTTTTTTTTTCAGACAGAAGAGTAAAAAGAGTAAATACGTATCAGTAG +TAAAAACAATGTGCGAGCTGGGAAATCAGTAATAATTAACTACTTGTGAT +ACAAATTCCTCAAGGAATGAAGGAGAAAGTGTACTTTTTTTGAGACCCGA +AGAACTCGGGGGATGTCCAATTGGGGGGATTACCAACTCGGGGGATTGGC +CCCGCCCACAGAACCGTGGCTTGCAATACGCCCATTTCTGCAACTGCCGC +ACGGTTTTAAAACTGTATTTTTCTCAATAGAGCGAGAATTAACAAGAAAA +AATAATTTTAAAACCGTGCGGCAGTTGCAGAAATGGGCGTATTGCAAGCC +ACGGTTCTGTGGGCGGGGCCAAACTCCCGAGTTGGTAATCCCCCCAATTG +GACATCCCCCGAGTTCTTCGGGTCTCCTTTTTTTTAATTTTGAATTGAAA +AATTGTCCGAAAAGTGCAAACGTAGAACATCAAAACCAGTGGAGGGGCGA +AATTTGATAGATCGCATGTTGCAAGAATGAGCATTCTACGAGTTTCGCGC +CATTTCTGCGTAGCGCGCACAATATTGTGCAATAAATCTCGGTATTTGCG +TACATGCATCATATCTTACGCGCAAATCATATTGGAAATTTCCCCGAAAC +ACGGGGAGGCAAAGCTAACGTGGCTGAAGAAATTTCTACAGTAGTCCCAT +TTGGCTGACTGAATATTCAACGCGAATAAGTTTTGTACACTATTGCGTAC +TTTGCGTACGCGCATTTTATTTGACGACAATTCGTCAATATCAGCTCTGG +CTAAAAGCGCTTTTCTCATTATTTAAGCGAATAAAAGTCGAAAAAAAATG +TTTTGTGATAGAGAATAGTAATTTAAAAAATAAAAAAGTGCATATTTTAT +GTTTCTCATTATGTTTCCACTGATTTTCTGAGAAAAACCGAAAATTTCCT +CTTTTTTCGATGAATTTCAGCTGAATAGTTTGTTTTTATCTAGTTTTTCT +TCCGATTGACTGAATAACACATTTAATAACATCAATATAACGTTTAAAAC +ATTCATTGTCTCGAAAACCAATATAAAACTCGTCAGAGAGGGATACTTAG +TAGATATGCTGAACAAGGAAAAGAGAGAGAAGAACATTAACCGAATGGGG +AGGGGGGAATAAGAAATCTGAACAGGAACGAAATATAAAGAACATTATTA +GAAAGAACAAGCATGGCTTGATCTTCTTGGCAGTCGTCTCCTTATCCTAT +CACTTCTTCTCGGCGTCCTTCTGATCATGCTACCGAGCAACGTGGCACGA +TCGAAGAGTTTCACAACGGTTTGATACTTTCGCTCCACGAGGGGGCTCCC +AATTCAGCGAGGGTCCTCTCACGAAGTTTAATTTTTTAAAATTAAAAAAT +AAGTAACACCTCAAGAATTCCATCGAAGTTGTGCTCCTTTGCAATAAGAC +GAAATTTTTTTTTACGGAATTGAACAGGATCATTGAGGTACGGCATGAAA +ACGGCTTCCTCGTTGAACGATGTTGAAGCTCCTTCACCATTGCACCTGAA +AATCAACTTCTAAATTTTCCAATTTAAAGAAAATCCACATACTTATCCTC +GGAAACGAATCCAATATTCTGGTTGCTGAGTGGAATTGCTTCAAAGATTT +TGATCAGATTTTTTTTTGAAATTTTCGATCACACATCTTGTATCCACCAA +ATCGCCGAGTGCTTCATGAACTTCAGACTCGTGCTTTCCAACCTCTTCCA +TGAGCTTCACTTCTTCTGCTTGGAACTTTTGATTGCCTTCGGACCGATCT +GACTTGTAGTTTCTTCTTAAATAGTGGCTGATTGAGCAGTCGACCTTGCA +GTCCTACCTTCTTTGGCTTCTTCTGCGGCACTTGAGCCCTTGTAAGAGCA +CTTATTGCTGCTTAACCTTCCTTATTAATACTTCGAACAGCTTCTTCTTG +TTCGCATCTATTTCGAATTTTGTCTTGAAATCTTCCAATGCAGCGACAAC +GTAATATCTGGAAATTATAAAAACATTAAGAGAAAATATTTTGAAAAAAA +ATCGAAAATTGCACTGAATTCCTAAATTTTTTATTAAAATCGAAAAAAAA +AAATGAAATACGTGAGATTGAGTTTCGAGACTTTTTTATTCAGAATCAGC +ATATATTTCTCCATATTTGAGTAGGTTTTCAGAAATATTGTACCATAATT +TTTGGAAAAATGTAATTTTTAATTCGAAATTGCACTGAATTTCTCGAATT +TTTCACTAAAATCGAGAAAATAAATATGAAATACGCGAGATTGAGGTTCA +AGACTTTTTAATTCGGAATCAGCATATATTTTTCCATATTTGAGTAGATT +TTCAGAAATATTGTACCATAATTTTTCGAGATATTTTGAATAATAACTTA +CTTTTCGACGTTTTTTGCCTTTGTCCGGTTTAATCCATCGAATTTCGAAG +CGGTTTGCGTAGATTAGCTGAAAACATTATGCTTATTCCACGTAGTAACA +AGAAAAAACAAGAAAAAATAAGAAAAAACGAAGAAAAATAAGCATATAAG +TCAAATTAAAAATGTTTATTCGATCAAAATTCTTAACCATAGGAGGCGGT +GGCTAGCCGGCGCACTCTCGCGGCCACGTTAGCTTTGCCTCCCCGTGGAA +AGGAGCCATGATATTACGGAAACACTATTTGAATTCTGAGAACGCGAAAT +ATCTCGTAGCGAAAACTACAGTAACCCTTTAAATGACTACTGTAGCGCTG +GTGTCGATTTACGGGTTCGATTTTTAAAATTATTTTTTTTGTTTTTTGTG +TGCGTCATCGATTACTAAATTATAAATTATTTCCGTAAATCGACATACAA +TCGCTACAGTATTCATTTAAAGAATTACTGTAGTTTTCGCTACGAGATAT +TTTGCGCGTCACTCCTTCAGGCACCACATCTTACACTCAAAATCGAGGTG +AATTTCTGTGTATTTGACAGCAAAAATGTCGTGAAAAACAATTAAATAAG +GCAATTTGAAGAGGAAAAAACTGGGGCAGATGTGAGATAAGAAGAAGAAG +AAGCGGGGCTTCGACAACCGTAAACTAATCAGAGATGGAAAGTGAGAAAT +TTGAAATTTAAGACAAAAAAGTTAACAACGGGGGATTTTTTTTAGAGAGA +AAGAGCGAGTAATCGGGCAGCAGCAGAGAAAAAAAAAGATAATAAACAAT +TGAAAAAATATAAATATCGGGGAAATTATTGCTGAATAGACTGCAAATAG +GTGACAATCTCGGGCGGTACAGAACGAAGTGTCTCTGGACAATTTCCGGG +TCCACGGACAAGAACGGCCTGCGCAAAGTAGGCCTTGTGGTTGGCGATGT +TGGCGGCGACGGGCGGTTGCTTGGGAGCGTAACTCAGACGACAGAATGGG +TTCACAAATTCTCCCTCGGCGTTGTACATTGAAGCTTGCTCTTCTTCTGG +TGATAGGACGGCTCGATCGGAGGCTGAAGCAGCTTCCAGCAGCATTGCCA +CCTCGTATGACAGAATTCCGTATTGACCACTGCAAAAAAAATTTATATGA +GAAATTGAATTTAAAATGATTTTATTTGTAATTTTGTTTTTGTTAATTGT +CGTTAATTGTTTTTTTTTTGAGAAAAAACCGAAAAAAAAATTAAAATCTT +CATTTTTGATTTAATTTTTTTGTTGAAAAATCGGCAGTTTTCGATTTTGT +TTTTTTGAAAAAATAGGGAAAAGTCGGTAATTGTCGATTTTTCAAAAAAC +TGAAAATTCCAGATTTTGTCAGGAAAAAAAACGAAGAAATCGACAAAATT +TCAATTTTATTTTTTTAAATTTGTGTTTTTCAAATTTTTTTTTGATATGT +GATTTTTAACTTTTCTCTGGAAAAAAACCGAAAATTTGCAATTTTTCAAT +TTTTTCCAAAAAAATCTTTAAAAAATAGAAAATTTTCGTTTTTTTTTCTG +AAATATTTAAAAATTGTAACTTTCTATTTTTTTTAAACCCGTATTAAAGT +TTAAAAAAAAAATCGGAGAAAAAAAAACTGAATCGAAAATATGTGATTTT +CAATTTCCTTTGAAAAAAATATAAAAAATCGAAAATTTTCGTTTTTCGAT +ATTTTTTCTGGAAAAAAGCCTAAATTTTCATTACTAACACAAGCTGCTGC +GTGACATCGGCTAGCAAATTGCCCATTCCAATGGCAATAATCCGTTTCTC +AGGCCCCGTTGTCGTTTGTTTCAGACCTGGCAAATCAATGCATACGACCT +TCTCGATGAGCATTCCGAACATGCCAGTCTGAATATTCTCACACGATTGA +ACAAGATCCTGTGCACTCCGGGCGATCGTAAATCGACACAAGAACACGAT +GAATAGCTTCATAAACTTGGGTGTCTTCGACGATTGAACTCTTCGAAACA +TTGTATTGAGCACAAATGTCATCGCGGAACCCTCGAAGTGCTCAATCGAC +GGAAGAATCGTCGCCGCCAACTGGAAACCGTATTGATCCAAGGTTTTCGA +GCCCAAAAGCCGCGCCAAATGGCTCAAGATCAACCCAGAATTCTCCGAGA +CGACTCGCTGAGCATTCACGGAAAGGATCACTTCGAGAACCGAAAGTGCC +GCTGGAACATTCGCTGATCTCGCCCAAAGACGTTCGGATAGCAGAAACGG +AAGGAACGGTGAGAATTGATCGATCGATGAGTTTCTAGCGATACATGAGG +AGACGAGAACTCCCGTGATTTGGAGAGCATATGGGATGAGATCTTCCAAA +TCCTCGCGGAAGATCACTTCGATCAGTGGAAGGAGTTGAGCATCCAGTGA +GGCGCCGATTGTTCGGGTCTGGAACAGGAAATTCGTTAAAAAATATAAAA +TGTTCTTAAAATTGCTATCACTTTTTTTTTGAATAAGAAAAAAAATCACA +AAAAGGAAAACACGAAAAAGCAGACAAATGTTTCGATTTTGCAATTTTTA +ATTTTTTTTTTTCAGAAAAAAATTATCGATTTCTTCTTTAAAAAAAGAAG +ATTCTTTTCGATTTTTTCGGAAAAAAACATCGAAAAATTGAAAAACAAAA +AGTTTTGATTTTTTTTTCAGTGAAAATCGTTCAATTTTTCGGGGTTTGTT +TCGACAAAAATAATTAAAAACTAAAATTTTTCAGTTTTTAGGTTTCTTAT +CAGAAAAATTGAATTTTTTCGATTTTCCGAAAAATTAAAAAAAGGTATAT +TTTTTGAAAACACGAAAACGGAAAAGTGTTGGTTTTTTGTAAATTTTTGC +GTTTTCCAGCAAAATTGCCAATTTTTCCGAAAATTTTCAGATCGAAAGTT +AAATTATCGATGTCTATTCCAATTTCCGAGTTTCAGCGAATTTTTTTTTG +CAGAAAAATTTCAGAAAATTTGACAAGTTATGTTCCAATTTATGAAAAAA +AATTTGAGACCAAAGTGCGGCACGGAAAAATGGGCGGAGTTTAGAGTGGT +ATTTTTCTCTCAAACTACTCCTTACCTTGGTGATCAACACACAAATCGTC +TCAAACAAAAAGTGCGTGTGCACCGAATCCGCCGGATTTTTCGTCGCCGA +CTCGACCAACTGTGCGAGCTTGACCGCAATCGCGTCCGCATGCCGAATCG +TGTCGTCATCGAGAATCACAATGATCCTCAAAATCGCCTTGATCAGATAC +GGCGAGTTTTGCGCTTTGGCATCCTTGTCGAACGCGGTGACAAGGTTCTG +AAGGATCGAGGAGACTGGAAGATTTTGAGCCGAGAAGATTTTGTTGGAAT +CAGCGAGAAGGATCTTTTCAATAGCGTAAGCTGCGTACTTGTGCAGAATC +GGAGTATTCGAGCTGAGAAGAGCGTCCGCCGACTTGATCGCAGTCATAAG +GTGCTCTGGAGCCAGCTGTTTCCTGAAAGTGACCGCAAACTTCAGTGCAT +CAGCTTTAAGGATCGGAGTTTGATTGACATCGGCGTTGAGATGTGTGGCC +ACTTGTGTGATGAAGAAGTCGTTGATGTCCACCAGCGGGTTCGTCGCCGT +TACTCCACTCTTAGCAGTCTCCGTCTTCACCGCGATCGCCGTGATCAGCG +AGTAGACAATGTCGATCTTGATCCAATCACCACTTCCCAGCAGGTTCTGC +ACGATCTCCCCCAGACATGGAAGCATTTGCGCCTCGAATCTTCGGCAGAG +ACCTCGCGCAAGATCGATGGCTCCACGGCGTCGAGTTCCTACATCGGTAC +CCTCGATGTCTCGCTTCATATAATCCAGTGGCTCATCCTCGAACAGTTCC +ATATCCTGTTGACGAAGCAGAAGGTTCTGAACGCACACGTTCTCGGCGAG +AGTCTTCAGAACGCCTTCACCAGTGAAGTGTCCCTCGTAGTACTGTCGCT +GGCTGACCATCGACAGAAATTCCAGCGCGGCGCACACCATCGTATCGTAT +CGAGTGTCGGGGCCGGTAGACTTGAGCAGATTCCAGACGGCAAGGATGAT +GTCGGGCACGAACTCGGAGATCTCCTCCTCGTAGCGTTGCGAGTAGAGCG +TGAAGATCTCACAGATCTCGTGCTTAAGCTCGTCCAGAGTTGTAGGTTCT +CCCGAGTTGGAGGTCTGCGTCGGCGCGTCGATTTGCACGAGATGCAAGAA +GTGTGGCATCCAGTCCTTGAGATGATCCTCGAAGTATTCCGGAATCTCCT +GTGAGCACAGAGAATGGTAGACTTTTGCAATGAGAAGTAAGACTCGGAGC +CATTGGGCGATCTCGTCGGCTCCGAGTTGATCCTTCCGCTGTCCCACCTC +CATCATGTTCCGTAGCAACAGAGTTAGAGGCTCTTGGGTCTGAAAAATCG +GTTCTTTTTATTTGTAACTGAAAAATCTGGGGAGAAAACAGTTTTTCGGT +CCAAATTCGAGACTGACATTCAGATTTCTTCAATTTTTTGGCTCAAAAAT +TTTGAAAATTTGTCCATTTTTATAGGAAAATTATCAATTTTCGCCAAAAA +TTCCTCATTTTTGCTTTAGTTAAAATTTTTGACTAAAAAATCATAAAATG +TTGAATTTTTCACGATTTTTCGGAAAACAAGGCCAGCTTTAGCTAGCTTA +AATGTCTAATTTTGGTCATTTTTTAGGGTCAAAGCGGACAAAAATTCAAC +TTCCGACGGCTGCGACGTAAAAAAGTGGCCAAAATTGGGGATTTTAGCTG +AAATTAGCCAAATTTTGAGCCAAAACGCAACTCACGCTCAGTAGACACTT +CTTCAGCTCTTTCCAAAGCTCTGCTGACTTGGATTCGAATCGGAATTTGC +GGAAAATCTGCTCCATCGACGCCAGCGAGGCCACCAGGTGATTGAGATCC +GCTCCGTTCAGGAATTTCGACAAATATGGAACCAAATCTGGCCATTTTTC +GGGAAAATCTCTCTGAGCGATGAGATACAGAGCATTGGACAGGATTTCCT +GAACATTTGATTTTGTATTGAACATCGCTTCGAGAAGCATGCTTCTGAAC +TGCTCCTCGTCTTCCTGGCCCATTTCTACCTCTGGTGCCGGGCCCTGAAA +CAATTTAAATATAAAATTCACGCATTTATTCAAATTTTCCAACCCAATTT +CTCTTCACAAAATTTTTCAAAGCGACAGCCGCGGCGATTCGGATCTGCGG +AGCAATTTGTTGCTGTTCGTTGACCACCAGTTGAAGAATTTGAATGATAT +AGCCTGGATTTGATTGCAGCGAGCGGAGCGCTTCTTCTCCACGCTTGCGA +ATCGCAGCATCCGGCTCCAGAGTCTGCTGGAGAGCTGCTCCGATTTGCTC +CATCTGAAAATAGGGAAAAATAGCTGTTTTGGGGGTGAAATAGGGAAGAA +TTAGGTGAAAGGACAAAGATAGTTTAGCTTAAAACTTGAAATCTAAAATT +TCCGGTCAAAATATTAAAGTTTTACGCAATTTTTCGCAGGCCCGCGGGGA +ATAAACTCGCAAAAATTCGCAAAAATAAAAAAAAAATTTCAAAAGTGTGA +AGTGTTTGCGTACAGCGCACCCGACCCGACGCGCAAATTTTTTTCATTAT +GTTCTCTGTTTTCACTGATTTTTACTGATTTTTCCTAGTTTTCCCTTGAT +TTTCTTCAAATTTTCCACTTTTTCAGCAAAACGTGCATAAAAAAATAAAT +TAAAACATTTCAATTTTCAAAACTTTGCAAAATAAAGGCGTCGTTGCGTA +CAATGCGCACGACTTGACGCGCAAACTTCCCAATTTTTATTCTTAAATTT +TCCTGGATACCCCTGGTTTTTTCTCTGTTTCCCCCCTAATTTTTCGCATT +TTCAGCAAACATGGGTGTTGATAAAAAGCAAAAGCAACGAAAAACCAATC +CATTCGAGCTAAAATTCAACAAATCCAAGCATGACGTGAGTTTTTCAGAG +TTTTGAAGAAAAAATCGATTTTCTCGCAGATTCTCGGCCGGAAAAAGGGC +GCACAAGTTGGAGCACCGACTGCGTCACGAAAACGAGCTCACGAGCAACG +TGAACAGACGCTAGGCGTAGAATATGACCGGAAAAATAAGATTAGCAAAA +TTGTCGACAAACGGCTCGGCGAAAAGGACGGAAAAAGCGAGGAGGAGAAG +GGCGCGATGAGATTCACAGAGGAAAGAGTCAAAAATTATAAAAGAGCATC +GAAATTCAACTTGACAGATGATGGAGATGAGGAGGAAGAAGGTTTATTCC +GAAATAAATTGAGAAAAATTTTAATAAAGTAAATTTCAGTACTTACTCAC +AAGGGAAAAGCGCTCTCGGACATTGAAAAATACGACAAATCGATGATTTC +CGACTCGGATGACGATGAAGAGCCGGGAAATTTGGGCTCAAATATGGTAA +AAGTGGCTCATTTCGGTGGTGGAGAGAAGACCGCCGAGGAGCACGTCCGC +GAAAAAATCAGCCGAGAGGATATGATTTCGAATTTGATTGCGAAAACGAA +GCTGGCGCGTCACGAGAAGCAACAGCAGAAGGATGAGCTCGAGCTGATGA +CAGAGTCGTTGGATTCCAAGTATCAGGCTTTGATGGGCAAAATGAAGGCT +TCATTTAGGCCGACCGGGCGCCAGCCGCTGGAAAAAGATGATTACGACAA +ATTGGTACGGGAAACATCCCGGTTTTCTCCAAATTTTTAAGATAAAAGAT +AATTATAAATTTAGAGTGAAAATCGATTTTTTTCACAATTTTTTAGTGGA +AAACCTAAAACCCAAAAAACTTGATCTGAAAATGCTAATTTTTAACCATT +TTTGCTATGGAAATTGGAAATTTTCATTAATTTTGCTGTAAAAGTTGAAG +AAATCCAAGTTTTAGCTTTGTAATCAGAGAAAACACTGTAAAATTATTTC +GGAATTTGTGCAATTTGAAGTGAAAAATAAAACATTTAACTTCTTATCGC +GAAAGAAATTGAGCTGAACTGAGAATTTTTTTGACGAAAAATCATTAAAA +AGTCAATTTTTTTGACAAAAATTCGAGAAAAGTCGGTTTTTCTTTTGACA +AAAATGACGAAAAAGGCAATTTTTAATTTAAAAAAATAAATTTTTCGCCG +AAAAATAACTTTAAAAAAGTCGTTTTTTTACAAAATAAAACAATTTAAAA +TAACTATTTTTCGACAAAAAAATTAAGAAAAAGCCAATTTTTTTGTTTAA +AAAATGATAGAAAAAGGCTTTTTTTTTGTTTCTTCGCCTAAAAAATCAAG +AAAAATAGGTTTTATTCCATTTTTTATCCAAAAATTATTATTTTTCCAGA +CAATCACCTTGAAAACCGAAGCCGACGCTCGTGCCACCCCAGCAGATCGT +AAGCTATCCGAAGAAGAAGAAGCTCTGAAAGAAAAAGAACGTCTGGAAAC +TCTCGAGGCCGCCCGTATCTCGAAAAATAATGCATTTTTCAACGCAAAAT +CTCATTTATCAGCCGATGCCGACGTTGATATCGATGCTGGATCGAAGGCC +GACGCCAGAAAAGTTCAGGCGAAAAATTCGAGATTTGAGGTCAAATTTGA +CGATGAAGGTGGCCTGATCGATGAGGATACGGTGGAAAAATCCAGGATTT +TAAAGAAAAATCTGGATGGTTCTGATGAATCTGACGATGACGAGGATCTA +GAAGATGAGGAAGAGGATCTGGATGATCTACTGGAAGATGAGGATGAGCT +GGAAGAAGATTCCGATGATGAGGAAGCTCAGGAAGCCCAAAAAGTCGTCA +AAAAAGCGAAAAAATCTGCTCCAGAACCCGCTGAAACTCTGCCATTCGTA +TTCGAAATGCCGAAAAACTATAAAAAATTCTGTGCTCTTCTGGAAAAACA +CTCGGAATCGATGGATTTAGTGCTGGAACGACTCGTGAAATGTCATCATC +CGAGCCTTAAAGAAGGAAATAAGAAGCGTCTGAATAAGCTTTTCCTCTTG +TGTTTAAGATGGTTTGATGATATGTCGAAGGAGGAATTGACAGCGGAAAG +TGTGAAGGAAATGAATTTAGCGCAGGAAACTATGCATGCGTTGATGAAGG +TAGCGATTGGATGGAAAAGCTGAAAAATTACCGCACTTTTTAATCTGAAA +ATTGAAAAAATTCGAGAATTTTTGACCTAAAATTTTGAAAAATTCCCGAT +TTTTATACCCCAAAAATTGCAAAAAAGTCCCGATTTTTTACCAAAAAATG +TTTTAAAATCCCCGAATTTTTTACCTAAAAATTGCAAAAAAGTTTCGATA +TTTAGACCCAAAAATTGCAAAAAAGTCCCGATATTTTTACCAAAAAATGT +TTTATAATCCCCGAATTTTTGACCTAAAAATTGCAAAAAAGTCTCGATTT +TTAGACCCAAAAATTGCAAAAAAGTCCCGAATTTTTTACCAAAAAATGTT +TTAAAATCCCCGAATTTTTGACCTAAAAATTGCAAAAAAGCCGGTTTTTT +TACAAAAAAATGTTTTAAAATCCCCGAATTTTTGACCGAAAAATTGCAAA +AAAGTCTCGATTTTTAGACCCAAAAATTGCAAAAAAGTCCCGAATTTTTT +ACCAAAAAATGTTTTAAAATCCCCGAATTTTTTGACCTAAAAATTGCAAT +AAATTCCAAAAACTTTGGCCAAAAAATTAAAAAAAATACCCGAATGTTTG +ACCCAAAAATTGCAAAAAAGCCCCGATTTTTTGAGAAAAATCATGTGAAA +TTAAAACCTTTTTTTTTTGAAAATCAGTCTCGAAAAAAAAAAGAAAAACC +AGGAAAATCATGAAAATTTAAGAAAAAAATCATTAAAAATAGGAAACGAT +CATGGAAATATTTTTAAAGAAACATTATATAAAAAATCATTAAAATTTCA +GAAAAAAAATATGGAAAATCCTGAAAATAAAGAAAATAATATTAAAAATT +CAGATTAAAAAACGCAAAAAATTCAACAATTGAAAAAAATTTCAAATTGT +TTTTTGCAGTTCGACATTCAATACGGAGTCCGATGTGTGCGTGCTCTAAT +CCGTCAACACTGGAAAGGCCGCCAGGATAAACAGAAGAGTAGCCCAGTGT +CATTTGGATTAATCTCTGCAATTCGTCTTGTTTCCGGCCTCTTCCCAGTT +GCCGATTCCTGGCATCCTGTAGTGGTTCCGGCTCTTTTTTTGGCAACTGA +AGCACTTTGCTCGGCGAAATGTGCCAATTTGAATGCGTTGGCTAAACAAA +TTCAATTGGCTAATGCTATTGTTGAATATGTGTCTGAATCCAAGAGGTAA +TACTTGGAAACGAACATTTAAATAGGCAAATTTTGAAAAAAATACTGAAA +GCTTTGATATAAAATAGGAAAAGTAACGAAAAAAAAAGCCAAAACCACCA +AAAATATTATTTTCAAAAGCTAACTCAAAAAATTTAAAATTCAGAATTGT +CGCTTAAAAAAATCTATTTTTTTCGATATCGAAAAAAGATTACTATAAAA +ATTCAAAAAAGCAATTTTTTAAAATATAACTTGATTTTTTTTTCTGAAGT +TCATTTTTTAACAAATAATTGCATTAATTTTCCATTTTAATGTTAAAAAA +AAGCGAATTTTTCAAAAATTGATATAAATTTTGTTTTGGCAATTTTTAGA +TCAGAAAACATTGAAAAAATACAAAAATCCCGTTTTTTTTTAAATTAATT +TTTTAGAAAAAATTGCAATTTTTCAAAAATCTTCCGGTCATTTCTCTATT +TTTAAAAAATCTCTCGTCTCTTTTAAAAAAATTTAAAAAACCGAATTATC +GAAGCGTATCAAAATTTTGAAATTAAAAAAAAAACCGAACTCCATTTTTA +CGAAAAATCCGAAAGTTGAAAATTGTTTTCAATAAAATAAATTTCAGATA +CGTCCCCGAGCTGGTCGCATTTGCTCGAAGTGCTCTTCTGCTTGCAGTTA +CAGAGAAAAGTGAGAAATTCGCGACAAATGGATTCCCGATTTCCAAGCCA +CACACGGAAATGTTATGCTTTGAGGAGAAGGTAAATTTATAAAATTTGTT +TTTTTGAGCAAAAAATTGGTTTTTTTTTTTGGTTTTCTCTTTAAAAAAAT +TTGCTTAAAAACGCTCAATATTTAAAAAAAAAACTGGCAAAATCGAATTT +TATAATATAAATTAAAAATTTTGTTCAAATAAAAATGATTTTTTTTTGAA +AATTTAGTTTTGAAAAATTTAAAATTAAATTTTAAATTTTCACAAAATTG +CCAATGATAAAATGTTCACTTTTTCTTGTATAAAACTGCTTGAAATTTTT +TAAAAGCAATTTTCCGAAAAATAATTTTTTAATAGATTTCTGAAAAACCG +AAAAACCACCGATTGAAAAACGAAAATCAAGTTTTTTTCCGAATTTTCTA +TTTTTAACAAATTAAATATCAATTTTGCACATACAAAACGGTTAAAAAAA +AACAAAAAAAATTGCCGAGAGCCAAAAAAATTTAAGTTTCAGCGATTTTG +AAATTTTTTTTTTAGGAAACACGGTCTCCTCGGGTGGAAACGAAGGGGGA +GGGAGATTGCTTGCGCGTTTCACCGATGCGCCTTTCGCGTGCTGGCGCAC +TTCTGAATATTGAATTATTTTTGCGGAAAAAATTCATTTCTTCTATGAAA +TTTTCTTGAGAAAGCAAAGGAAAGATGATGAAATGAATTTTTAAAATAGT +TTTCTCAGTTAAAAAGAGAATACCTTGCTGCAAAAGGTTAAATTTATTGA +AAAATTGAGAAAATAAGAAGTTTATCTTTGTTTTCACTACATAAAGTGGG +GAAATCTCAAAAAAATTTGAAGACAATTAAGAAATATAATTAAATATATA +GCCTGAAAGTCAAATAAGAAATGAAGGTTTGGTCACAAACAATTTTATTT +TTGAATTGAAGTTTTGAGAAATGATCATGTGCCAGAATCACTAAATCTGA +GACATTCAGCCCAATTTCTTTAATTTTCTGTGATTTTATCATGGAAGTGT +GGCTTTTTCTGTGATCTTGCCAGTTTTAACAAGTTGAAATTGGAAAATCG +TGAAGTGGGAAACTAGCAGTGAAGCTTCCAAAAATTTCAAGCCTTACTGA +AAGGAAAGTATTGGAAACTAAAAACGAAAGCTTAAGAAGATACCGTTTTT +ATATATTTGAGTTTTGAAAAGCCTTAATAGGTTTTAAATACAGTTTTCTC +AAGAATTCAAACTTGTAACGATTAAGTTGAGGCACAGAATAAGATGGTAA +TACTAAGTTATGTTGAAAAAAGCCAAGAAAGACTGAAAACATTGCTTTCA +ATCTGATTTTTTGTAAGTAATGTAATGTTGAAACATTATTCTTCATAGTT +CAGCACTTTGTATGGCTTATTTGAGCCCAAACGTACAGTAGTATGTGGCA +AGAAATAAAATATTGTGCCAACAAAATTGGAGCCGAAAAACCCATGATAA +AATGTTTAATACGTGTATTGCTCTAATAAAATACCAAATATTAATTAGAT +TCACTGTCTCGACTCTTTTTAATTCAGATTAATAACTTTTAGCTCCTCTT +TTTAACGAAAAATTATAACTGGATTTCACAAAAAGAGTTCGATCTGAGTT +CTTTCAACAGGTACATAGACGAATTATATCTTAAAATGACGAGAAAAGTT +TGCTCTATAAACGTTATCATTGCAGGTTATGAGAAAAACAAATAAAAATT +TAATTTTAAAAAATCCGAAAATTCAGTTGTTATTTTCAAACAGTTCGTTA +TGCATTTCCACCGAACGGTTTCCGATAATTTTTGTTTCTCCACTTTCGGT +TCAGTCTACTTTATAATTGTTATCATTTTGAAATAGAAAAATCGACGAAA +AACTAATAAAAATCGAGGGAAATCACTCTTCAACGGTGAAATCTCGGTGG +ACGCAATGAAGCTGCAGCATTTCAAAAAAATTTTAGAAGCAATTTTGGTC +ATTTCAGCTTCAAAAAGCTTTAAAACTTAAAAAAATTAAAATTCATTTCA +AAAAATTTGAAATTAGTCATTTAAAATATAAAAATTAGAAAAATTCTAAT +TTTCAGCGAATTTTCAAATTTATTTTTATTTCAGAAAAATTCAAATTTTG +GCTTTCAAAAAAGCTTACAAAATATTAATTTTTAAAAAATCTAACTTTCC +CAATTTTTCAGTACACTGGCCCCGCACTCCAGCCAATCTCCCTGACCACA +ATCTTCAACAATTCCCCATCCGATCCATCTCTAAAGCTTCACGTTCTTCG +TGCTCTGCTCTCCCTCATCCAACATCTCCGTGTAATCTACTCCAACCAAA +ATGAGACCTATTCTATCGTTTTCAAGCCATTCCTCCGGATTTTGGAATCA +ATTCAAGCCAAAAATCTTCCAGCCGAGGTCCAGGAAGAGCTGGAGACTCT +GTGCGCCTCAATGAAGGCTGAAATTGGAGCCAAGTGCCGTCTGGTGCACC +TGTCGCTGGTGAAAACCGAAAAGAGCATGCTGAAAATGCTGGAACCCCGT +TTCGAGTGGGATTTCGATCCGGAACGCCCACATCACGGACCCAAAGACGA +GAAGAAGAAGCTGACGAAGAATCTGAGGAACGAAAGACGCGGAGCCATCA +AGGAGCTCAGAAAGGATACGGCATTCTTGGCCAGGAAGCAATTGTCGAGT +GTCAAGACGAAGGATCGTGCGAGAATTGCGGCCACGAAACGTGTCATGGG +CGGTCTTATGCAGCAGCAGGGTGAATGGAATAAGGAGAAGCGTACGGCGG +ATGTTGAGAAGAAGAAGGACAAGAAATAATTTAAATTTTCCTATTTTTTG +TTTGTTGAAAATGACTTTATTTGGCAAAAAAAACCCCTAAATTTCAGTTT +TTCTCGATTTGTTGAAAAATAGTCAAAAAACTGATTTCTATGTTATTTTT +GGTCAAAATTTGCCTTTTTCAAACATTTTTTTTGCCATTTTTCCTCCATT +TTTTGTTATTTTTTTTTTTCGTTTTGTTATGAGATATGTTTCTGTTTTGT +TGACATTTTTTATTATTGAAAATTAAACGAGTTTTCTGAATTTTTTTGTT +CAATTTTTTTGAAATTTTCCGTTTCACATACGTTTGTCAATATCTCGATT +AATTTTTGAAGTTTTCCAATTGACTCGCGCATTTTCTAAAAAGTTTTTAA +ACTTTACATTGAAAATACCCCTCTAACTCGAATATCTGATTTTATTGGAA +TTTTGAGTTTTTTTAGGTTAAAAAATTCTTGTGCTAAAATCATCCATTAT +AGTTCGTAAGTCAGCAAATTTTGGCTCAAACTTAGAGCGATTTCCAATTT +ATGGAGTTTTTTGTTCAGAATTCTCGAAATTTTCTCATTTCTGGAAATTT +TGAGTCTACGAGTCACACAGTTGTTCCGTAATTAGCTTCACTTACATCTC +CTCAACTCTGCAAACTCTCAAACTTTCGGGAAAGGGTCTCGCCACGAAAT +CACGGGTGGGCGGCAATTGCAGTTCGGCAAATTGCCGGTTTGCCGGAAAT +TTTCAATCCCGGCAAAATTCCGTTTGCCGGAAGTTTTTAAACGGGATCTT +TTATAAGACGGAAACACTTAAAACTGCCATTTTTAATTTTTTGCCCGTTT +TCTCTAAATATTTTCATAGAATTTACTGACTTTTTAGGATAGATGTTTTC +ATGGGATGTGCACATGTTGTTCCGGCAAATCGGTAATTGCCGAAAATTTG +AAAAACGACAATTTGCCAAAAAAATCGTTTGCCGTTCACCCCTGTATTGT +ACCATTTTTGGCGAAAATGCGCGTAAATTAATATGCTTGCGTGTGTAATA +TTTCGTTCATATATTCTAAATATACGCACCTTTTGAAATATTCATAATAT +ATGCATTTACGTACGTTCGAGAATATTTTGGGAATACACATTTATCATCA +TTCCCACCCGTTGCCATAGTATCCTCATCCCCGCCCCGCCCCGCCCCTTT +CTCTCATTTCCTCTTCCAAATCCTTAATGGCTCATCCGGTCATTGGAGAG +ATATGGCAGATGTGGCGGTTTTGACGAATGTTCTGGAGAACTCGAATTTT +ATATAACTATTAGACAATTTCGATATTAAAAACATTTATATGTAAAATTT +TCAATTTTTTGAATTTGCTCGCCGAATTTTGACTTTCTGACAATTGTGTG +TCGATTTACGAGGGTTATGTATATTTACGATATGTTTTTAATCATTATCG +AATGCTGATTTCCGTTTTTCTACGAGTTGTCTTCATTTTCGTTGGTTTTT +TTTTGTTTTTTTTTTTTGAAAGTGTATTTTTTAAGGTCAAAAAACTAGAA +AAATATTCAGTTTTCAGTCAGGAAAACCATTTATTTGGTTTTTTCAATAT +TAAAAAAATTATTGGGAAAAATGAATGAAACTCGTCGAAAAACGAAAATC +ATCATTCGATAAAGATTAAATATTTCGTAAATCGACACACATGTCTCCGC +CGCGAAAAATCGAAATTTCATAGAGGCATAAAAATTCACAATATTTTAGT +TTTTTTATTTTTTATTTTAATCCAAATCCCTATTCATGCTTAGATTTTTA +GGTGTTTTTCTGTAAAAAATCAAAAAATTGTATATTACTCATAAATTTTT +CCAATTTTCTCAAACCTTGGATCTCGCCACGACATTATTAAAAAATTCCC +GTTTTCTGCAGAAATGACGACAACGGAAGAAGCTCCCAAATCGCCGCTTT +TCGAGGCAATCGACAAAAATGACACTGAAGCAGCGCTGGCACTGCTGAAA +ACGAAGGAACAAGCCGCTCAACGGGATCCCAGTGGAATGAGTGTGCTGGC +AGCTGCCGCGTATAGGTATGCACCTTTAAAGCGGCGACGGTTACTGTATC +CTCGCAGATTGTTTAAAGGTACATACCGTAATCCGTTGAATTTCAGAGGA +AATCTTACGTTGGTCGAGAAAGCGATTGAGCTGAAATGTGATGTGAATGA +TAAAACCGATGGAACTCTGTACACTCCACTCATGTTTGCCGCCTTATCAG +GTAGGGCAAAAATTTTTTAAAAAAATTTTTTGCGTCAAATTTGATGCAAA +TTCTGGTTTTTTACCGTTGAAAAGTAAAAAAAAATTCCGAAAAAATCGAT +TTTTATGCTAACAACAAACTTTTAAGTGAAAAATCGTGGAAAATTAGACC +CAAATCACGTATTTTTGATCTGAAATTCAATTTAGCGAAAAGTCATCGAA +ATTTTATGGTTTTCGCGGTGAGACCCAATATTCGCAATTTTTTTTTGCAC +CAAATACAACACATTTGACGCGCAAATTCAAATTTTTGAAACTTTTTTCC +GTTTTTACAATATTTTTAGGCTGAACCCCAATATTTGAAAAAAAAAAAAC +CAATACACTATATTTTACGCGCAAATGTTAAATTTTTATTTAAAATCCTC +GTAAAGTTCTATTTTCTTTTTTTGATCGTTTTCAAGCTCAAAAATTCAAA +TTTCAATTCGAAATATTACCGGAACACAAAATTCTGAAAATGCGTACTGG +TCAACATATTTGACGCGCAAAATATCTCGTAGCGAAAACTACAGTAATTC +ATTAAATGACTACGGTAACGCTTGTGTCGATTTACGGGCTCGTTATTAAA +AATCATTAATTTCAAAAAAATCGAGCCCGTAAATCACCACAAGCGCTACC +GTAGTCATTTAATGAATTACTGTAGTTTTCGCTACGAGATATTTTGCGCG +TCAAATATGCTCAATACACATTCTCAGAATTTTGCGTTAACGTATTACTA +CTTTCTTAGTTTTTCCAAAAAAAAAATTCGAATACACCATATTTGACGCG +CAAACTTTTTTTTTCAAAGCAAAATTGTCAAACGTTTGCAGGAAAACAGG +ACGTATGCCGCCTGCTAATGGACTCCGGAGCCCGTATGTATTTGGTGAAT +GGAATCGGAAAAACCGCCTCTGAACTGGCGGCATTTGTGGGTCATCACGA +GTGTGTGGCAATTATCAATAATCATATAACAATTGATGTGATCGAAGATC +TTTTGCGGCCAAAAGTGAATGGAAAATATGAAGGAGCTGAGGAATATCCG +GATGAGCTGGCTGTATTTATTCATTCATTGTGTGGATCACATGAGATTCA +TCCTGTTAAGATTATTTTTCGATTCAGTAAATATCCCGATTCGTTGAAGT +ATAAGAAAAAGGTACATAGCTGTGTAGTTTGGAAAAAAAACGAAAAATCT +GAAAATTTGAGAAATTTCCTTAAGCTTTTTCAAGATGCGCATTTTTGTTC +ATTCTTATTTTCAAAAAAATCCAAAAAGTTTTTTAAAAAATTTAATAAAG +CATTCTTTTTAATTTCAAAACAAAAAAGTTATACCAAATAAAAACTTTTA +GTAATCAAAATTTTTCACTTTTTCTCGGTTTTTCTCATCGTTTTTCAAAT +TTGAGATCTCTTCCTGAATTTTGCCTAAAAATTGATTTTTTCAAAATATT +TTCAGAAATGATTCTTTCTGTGAAAAAATGTTTGAAAATGCGAAAATATT +CGAAACTAAAAAAACTTTTATTAAAATAAATTTTTGAAATTTTTCAGAAT +TTAAAAATTGAATCGAATTAGGTATCAGTAGTTTTCAGATCGATTTTTTC +GAATTTCTGAATTTGTTAAAAACTAGAAATTAAAAAAAAAACTTTTGATG +TTAAATGTTTTTCGAGATTAAAATAAACCGAAAACCCAAAAAAAATGTAA +AAATTGTGTTCTTTTTGTTATAATAAACCAGAATTTTCTCGAAATTTTCA +GAAGGTTCTAGAATATTTCAGAATTTTCTCGAAATTTCCAAAAGGTTCTA +GAACATTTCAGAATTTTCTCGAAATTTTCAGAAGGTTCTAGAACATTCCA +GAATTTTCTCGAAATTTTCAGAAGGTTCTAGAATAGTTCAGAATTTTCTC +GAAATTTCCAAAAGGTTCTAGAACATTACATAATTTTCTCGAAATTTCCA +GAAGGTTCTAGAACATTCCAGAATTTTCTCGAAATTTTCAGAAGGTTCTA +GAATATTTCAGAATTTTCTCGAAATTTCCAAAAGGTTCTAGAACATTTCA +GAATTTTCTCGAAATTTTCAGAAGGTTCTAGAATATTTCAGAATTTTCTC +GAAATTTCCAAAAGGTTCTAGAACATTACAGAATTTTCTCGAAATTTCCA +AAAGGTTCTAGAACATTACAGAATTTTCTCGAAATTTTCAGAAGGTTCTA +GAATATTTCAGAATTTTCTCGAAATTTCCAAAAGGTTCTAGAACAATCCA +GAATAATGTTTTCAAAAAATTCAAATTTGAATTCCCGCCAAAATGTTTTC +AAAAAATTAAAATTCGAATTTCCCGCCAAAATATGTACAGTACTCCTACA +GTACCTCTACAGTACTACTACAGTACCCCGACCATATCCCACTACTAACC +CCAAACCTATATCTCTTCAAAAGACTAAAACACAATTTTTCCTAAACTAC +AGTAATCCTACCGTACTCCTACAGTACTACTACAGTACCCCCACCATATC +CCACTACTAACCCCAAACCTATATCTCTTCAAAAGACTAAAACACAATTT +TTCCTAAACTACAGTAATCCTACCGTACTCCTACAGTACTCCTACAGTAC +TACTACAGTACCCCGACCATATCCCACTACTAAGCCCAAACTAATATCCC +TCCATCAGCCGAAAACGCCTTGCCTTTGTAAACTATGACGTCACTACTTA +ACAAACGGACACTATTTTTTTATATTTTTTTTTCAAAGCAAAAACCACCC +ATTTTCCAGATCCTCTACGTCATCGATCGTGTCTTCGAGAAACAGCTTCG +ATGTAAGGAAAGCAATGAAATAATGTCGCTCAAGCTTTGGCTAATTCTAT +TTTCAATGCGTGAAACCTCGAAATTCGTGGAGTCGAACAAGGAAAAGTCG +CCAGAAGAAGCGTCTCTACAGTACGCAAAACTGATTTCCACGTGGCAAGA +GGGCGATGAAACTAGGCGAGCACTTGACGTGATGCTGAGAAATGCGGTTG +CTTCGTTCCCGTATAAACATTCATTACTTCATGATACTCTACAAAAAGCA +CTGCAAAAAAGTCAAATTGGTGAACGACCAAGTGCCTATGAATACATTGT +TCAGGCACTTTTCGGACAACGAATCGCTGCGGTCTGCCAGTTTTGCTCGG +TTTGCGGACATCCTGGAGCCAAGAAACGGTGCACACAGTGCAAAGTATGG +AGTTTTTAGGGTTAAAAATAATTATTTAATAATTTAATAAAGCTCGAATT +TGGGAAATAATCAATTCCAAATTTTAAAAATATGGAAAAAATTTTATTCC +GTTACATTTTATGAATTTTCCCACAAACTCGGCATTTGGCTCTAGCTTCT +TGCCCAAGTTTAGCCCAAAAAATATTAACTTGAAGCTGTCTAAACTTGGG +CAAAAGTTAGACAAAACTTTGGCAAAACTTGGATTCAAGCTTTACCAAGG +TCTAACCCAAGTTTCACCCAACTCTTGCCAAACTTTGGCCCAAACTTTTC +TTATTTCGTTTCAAATTTGGGCCAAAGTTTGGCAAGAGTTGGGTGAAACT +TGGGTTAGACTTTGGTAAAGCTTGAATCCAAGTTTTGCCAAAGTCTTGCC +TAACTTTTGCCCAAGTTTAGACAGCTTCTGATCCAAGTTAACATTTTTTG +GGCTAAACTTGGGCAAGAAGCAAGAGCCAAATGCCGAGAAACTCGAATAA +AAATTGAAAGTTTTCAAAATTTCAGTTCGTTTTTAATTTACAAAATTTGG +CAGCTCTAACAATTCTTTAAAGATTCTTTAAATTAAAAAAAAGAATTATT +AAAACTTTTTAAAAAAATTCATTCTGTAGAAAATTCCCGTAAAATACTCT +TTGAAAATCCGGGAAAAAACTTCAAAAAACAAAAATAAATTCTAGACATT +CTGTAAATATCGAAAAAAGAACATTTTGTCTGTAAATGTATTAGTCAAAA +TTAATTTCTGATACTTTTTCCAATTTTTCAAAATTTTAAGTGTCGAGGTT +CAATTTTTTTGAATTTCCTGTTTTTCCTTTATTAAAAAAAGTTTTCTATA +ATATGCTGTATTTGAAAATTAAAAACTATATCTGAAAATATCGAGGCACA +ACGTTTTCAAGATCTGGTGAAATTCCGGATCTACGTTTTCCGGATCTACC +ATTTCCGGATCTACGTTTTCCGGATCTGGCACCGTGCCAACGCACAAAAC +GCTTTTTTGTTCACTCGACGCACGTTGTTTTTTGAAAATTTCTTCTAGAA +GAAACGCTTAACAACACGCGACGCGTAACAACGGAGCATCGTTATCACGT +TTTTCTCCGAGAAAAATAGCGTTTTAAGAGTTGGCACGGTGCCAGATCCG +GAAATGGTAGATCCGGAAAACGGAGATCCGGAATTCCGCCAGATCTTGAA +AATGTGGTGCCTCAAAATATCGATTAAAGAATTTTTTCTGAAAAATATCC +AATTTTTCAACAACAGAATAGCTAAAAAGTGAAAAAAAACTCAATTCTCA +TTATAAATTGCAAACAATTTCCAAATTTTGATAAAATGGAAAAGAGTTTA +AAAATTTCAGGCAACACATTTTTTAACTCTAGTAAACGTTTTTTAAATTC +CAACAATTTTTACAGCTCGCCTACTGTTCCCAAGAATGCCAAAAATTCGA +CTGGCCAATTCACAAAAAAGTGTGCTCATTTCTGAAAACGCGACAAGAAG +TGTCGCCCACCGACGAGACCGCCATGTCGCTGGACGATATTCAGGCTCAA +ATCGCCAAAATCGACGTGTAGAAGTGCCGATATTTCGATCTCAATATACT +TTTTTTCTGGAATTTATTTATTTTTAATGTATATTTCGGCTTCATCTCAT +TGCACGAACTTTTAATTTCATTTTCATAAATTCATTTTTGAAGTCATTCC +TTGAACAAAAATTCACTAAAACATGCATTAAGAAATATGGAATCCAAAAA +TTAATCTAAAAACCTTTTCAAAAAACCACTTCGTCAAAAACTGATGATGG +AAAACTCGTTGAAAAACGGAAAGAGTATCCAATAAAGATTAAAAATTTCG +ACATTTCGTAAATCGACACAAATCTCGTAAATCGACAAAAATGAAAAAAT +CAGGAACCCAAGAAATTCAATATTCTCATTTGTAAAGACAACTGGTAAAA +CATTTTCAAATCAAAAAATTATTTTTTTTGCCCTCAAAATTGATCTCCGA +ATACTATAAAAAAGAAAACTATAAAAAGTGGCGAAAATTCGAAATTTTTT +AACCCCTCTAAAATGGTTCATTTTAGTTGTCTAATGATACAACAAAGTAG +ACATAGTTCTACAATATCTGATAAATACTTGAAAAGTCTAAAAACAAAAG +TTTTTTCGTTTTTTTAACGGATTTTTAAAATCCAGAAGAACGAAAAAAAA +TTTTTTTAAGAGAATAGAGTAAACTAATCATGTTCGAGCAAAAAAATCCG +ACTTAGAATATGAACGGACCCAAGTGTATCATAATTATTTTAATTTCTGT +GTATCAGAATTATTTTAGTTTCCTTAGTGTGATTCCCAAACTGCTTAAAT +TCTAGGAAATATTTCTTTACTGGAACACTCTTAGCCACTGTACGCTGCCG +AACGAATAATAAGAGAATACAGAACACCAATTATGCCCGAGAAAAAGATC +CTACTCAGAATATAAACATAGTCAAATTTATCGGATGTATAAAGATTCCC +GAAGACACTTTCCAATTACCCAAATTGTTCATATTCTAAATCAAATTCTC +TTACTAGAACGCTCTTGGCCAATGTACGCAGCCGAACGTATCATAAGTGA +ATACAGAACACCAATTATGCCCGAGAAAAAGATCCTACTCAGAATATAAA +CATAGTCAAATTTATCGGATGTATAAAGATTCCCGAAGACACTTTCCAAT +TACCCAAATTGTTCATATTCTAAATGAAATTCTTTTACTAGAACACTCTT +GGCCAATGTACGCAGCCGAACGTATCATAAGTGAATACAGAACACCAATT +ATGCCCGAGAAAAAGATCCTACTCAGAATATAAACATAGTTAAATTTATT +GGATGTATAAAGATTCCCGAAGACACTTTCCAATTACCCAAATTGTTCAT +ATTCTAAATGAAATTCTCTTACTAGAACACTCTTGGCCAATGTACGCAGC +CGAACGTATCATAAGTGAATACAGAACACCAATTATGCCCGAGAAAAAGA +TCCTACTCAGAATATAAACATAGTCGAATTTATCGGATGTATAAAGATTC +CCGAAGACACTTTCCAATTACCCAAATTGTTCATATTCTAAATGAAATTC +TCTTACTAGAACACTCTTGGCCAATGTACGCAGCCGAACGTATCATAAGT +GAATACAGAACACCAATTATGCCCGAGAAAAAGATCCTACTCAGAATATA +AACATAGTTAAATTTATTGGATGTATAAAGATTCCCGAAGACACTTTCCA +ATTACCCAAATTGTTCATATTCTAAATGAAATTCTCTTACTAGAACACTC +TTGGCCAATGTACGCAGCCGAACGTATCATAAGTGAATACAGAACACCAA +TTATGCCCGAGAAAAAGATCCTACTCAGAATATAAACATAGTCGAATTTA +TCGGATGTATAAAGATTCCCGAAGACACTTTCCAATTACCCAAATTGTTC +ATATTCTAAATGAAATTCTCTTACTAGAACACTCTTGGCCAATGTACGCA +GCCGAACGTATCATAAGTGAATACAGAACACCAATTATGCCCGAGAAAAA +GATCCTACTCAGAATATAAACATATTCGAATTTAACGGATGTATAAAGAT +TCCCGAAGACACTTTCCAATTACCCAAATTGTTCATATTCTAAATGAAAT +TCTCTTACTAGAACACTCTTGGCCAATGTACGCAGCCGAACGTATCATAA +GTGAATACAGAACACCAATTATGCCCGGGAAAAAGATCCTACTCAGAATA +TAAACATATTCGAATTTATCGGATGTATAAAGATTCCCGAAGACACTTTC +CAATTACCCAAATTGTTCATATTCTAAATGAAATTCTCTTACTAGAACAC +TCTTGGCCAATGTACGCAGCCGAACGTATCATAAGTGAATACAGAACACC +AATTATGCCCGAGAAAAAGATCCTACTCAGAATATAAACATAGTCAAATT +TATCGGATGTATAAAGATTCCCGAAGACACTTTCCAATTACCCAAATTGT +TCATATTCTAAATGAAATTCTCTTACTAGAACACTCTTGGCCAATGTACG +CAGCCTAACGTATCATAAGTGAATACAGAACACCAATTATGCCCGAGAAA +AAGATCCAACTCAGAATAAAAACATATTCGAATTTACCGGATGTATAAAG +ATTCCCGAAGACACTTTCCAATTACCCAAATTGTTCATATTCTGAATGAA +ATTCTCTTACTAGAACACTCTTGGCCAATGTACGCAGCCGAACGTATCAT +AAGTGAATACAGAACACCAATTATGCCCGAGAAAAAGATCCTACTCAGAA +TATAAACATAGTCGAATTTATCGAATGTATAAAGATTCCCGAAGACACTT +TCCAATTACCCAAATTGTTCATATTCTAAATGAAATTCTCTTACTAGAAC +ACTCTTGGCCAATGTACGCAGCCGAACGTATCATAAGTGAATACAGAACA +CCAATTATGCCCGAGAAAAAGATCCTACTCAGAATATAAACATATTCGAA +TTTAACGGATGTATAAAGATTCCCGAAGACACTTTCCAATTACCCAAATT +GTTCATATTCTAAATGAAATTCTCTTACTAGAACACTCTTGGCCAATGTA +CGCAGCCGAACGTATCATAAGTGAATACAGAACACCAATTATGCCCGGGA +AAAAGATCCTACTCAGAATATAAACATATTCGAATTTATCGGATGTATAA +AGATTCCCGAAGACACTTTCCAATTACCCAAATTGTTCATATTCTAAATG +AAATTCTCTTACTAGAACACTCTTGGCCAATGTACGCAGCCGAACGTATC +ATAAGTGAATACAGAACACCAATTATGCCCGAGAAAAAGATCCAACTCAG +AATATAAACATATTCGAATTTATCGGATGTATAAAGATTCCCGAAGACAC +TTTCCAATTACCCAAATTGTTCATATTCTAAATGAAATTCTCTTACTAGA +ACACTCTTGGCCAATGTACGCAGCCGAACGTATCATAAGTGAATACAGAA +CACCAATCATGATCGAGCAAAAAGATCCGATTCAGAATATAAACATATTC +GAATTTATCGGATGTATAAAGATTCCCTATTGGGAAGTGGAGCAATCCAC +GACTGGTTTATCGGCCACAGTCCCCGGCTAGGACATGGCTTATATTATTG +GGCCAAGGGGAGCACCACCAGGCAGTGTACCTGACTCCCAGATCAGCAGT +ACATAGCACTTGAAGAATGGATCGTCCTTTAATCTTTTAATCTTTTAAAA +AGAATCGAAGGAACTCTCATCGGGTCATGTGGTTGTGGGGACAAAGAGGG +AGGCTTACATCAATACCAAATACCTGTGGTAGATCACAATACCTGTGGTA +GATCACACCCTATCCACAAAGAAAATCTGTGGACGTCCTCAAAGGAGGCC +GCCCGCGCCCTTGAGCTGGCCAACAAACCCTTCGAGCTGGGTGGAGGAAT +ACTCCAGCCGAGCGACTGAAAACGGCGGTAACGCCACGTTGTCGCACAAT +AACAACAAAAAAGCCCGCGGGCCCCAAGAAGCTCAAGAAGCCCACGGCTT +AATTTTCAAATCAATTACCTTACTATGAATCTCCTTTTTGCTCTACGAGT +CGTCGTTGATGTCATCCTTCCGTCCAACCTCCGTCAAACAGTCCATCTGA +CCATCCGTCCAACCAACATGTGGTGGAGTGTCCAACGCATCTGAAATTGA +AAAATATTTATATCTGATTTTTTAAATGGAACCATTTACAAAAAACATAA +ACGGAAAACGCTTAGCAAAAAAACAAACAATTAGTATTTAGAAAAACGGA +GACAAATGCTCTCGCGATCTTATTTATATTAATTTTCCAGTCGATTGCAA +GGCATCTGCTCCCACGGGTTTATATAAAATTGTGTAACTAATTTTAAACT +TCTCTTGAAACCTTTCAACCAGTACTTTTCAAGAGTTTTTGGTAATTTTT +CGATTTTTCAGAAATTTCAAAAAAACGGCGAAATTCCACTCAGAACCCTC +ATTAATATTTCACTAGTCCAGCACACTAACCCAAAAAATTATTTTTTTTT +TGAACTACAGTAATCCTACAAAATTGCTACAGTACTATTACGGGACCATA +ACAAAATTTTGATAATGCGTATTGCGCAACATATATGACGCGCAGAATAT +CTTGTAACGAAAACTACAGTAATAATTTGAATGACTACTGTAGCGTTTGT +GTCGATTTACGGGCTCAATTTTCGTAATGTTACACGACACATTTTTTTGA +CAAATGCAAAAAAGTGTGCGCCTTCAAATTAAAAAAAAATTTGATTTTTG +TTGCCGGCTTTTAACACATCGAAAAAATAAAAGAAACGAAAGTTTGTAAT +TACAGTACTCCTCTTAAACGCGAACACCTTTTCGCTTTTCAGAAAAACTT +GCGCCGTTTCGAAACCGGGTACTATACTTTTATATTAAAATCGATTAAAA +ATCGCGAAATTTTGCGGTGGAGCATATGTCAAATTGCAACTCGAAAAGAA +AAAATCTGAAAATGCATGCTGTGAAAAAAAAAGCAGCAGTACTCCAAGTC +ACCCATTGGAAAGAATGACTGAAAATTGAAAACAATTCTTCACTTTGAGC +GAAAAAATGCCGCGTTGAATGAGAGAGGGACGAATCGAAATTTAAAAGGA +GAAGATCAAAAAAAAATGTTTGTGGTAGGTCTGGAATCTTGCAAATTATC +GTTTTAAAATCAATTTTTAACACTTTTATATCATAAAAATAGTTTTTCAT +CAATCAATCGATTAAAATACCAACTCTCGAAAATTAACAGCTTTAACAGC +GCCGTCTACTGATTTGAAATTGCAGTCGCTGCCGCTCAATTAAATGTTTT +GCGCGTCAATTAAAATGCCTTGTACGCAGATGCGCGTCTCCTAAAAAATA +AAAAGTTGTCCAATTTTATTGAAAACGGGTATTTAATTCATGTAAATATG +CTGAATTTAGAAAATCTAGGTTTAACCTATCAAAAACTATAAAAAAGTGG +CAAAAATGGGCAATTTATGGCAAAAATTCACAATTTTGAAACTCCTCTAA +AATGGTTCATTTTATTGGTAGAAGAGGACTAAAAATTGATATCCGAACCC +TAAAAAAATTGTCCTTTTTCAATATTCAGAAGAAAATTATGAAGTTATTT +ACTTCCATTTTTCGATTGTACGGTAAATCAAAACTAAAGGTGGGCACGGT +ATCTGATAAAGTTACGATCGTTCCAGGATCACGAAAATCGAATAATTACA +CAGCCAGAGTTACATGAAACAGTGTTTGGGAAATTTAAAAATCAGTACAA +GAAAACCTCAAAAAAAAAACAAAATTACAGGAAAAAACGGAAATTTTCAG +TAAAAAATTATAGGGTATGTAAAATCGATAAAATATTTAAAATTCAATCG +TATTCTCCGTTTTCGGCGTTCGGATCGTTCACTGGAAGTACGGGATGTCG +AAGTTTGAAATTGAAGAATTCGCACCAACCGGCTGGAAGTAGATCGTGGG +AGCTGCAAAAAATGTTCGTGGCCGCGAAAAAAATCGGTGGCCGATTTTTG +TTTTTTCGCGGCCACGTTGTGACTAGACGGCGAAATAAAAATTTGTTTTT +TGGTTTTTAGTGTTCAAAACTGTTGTTCTTGTTGAAAAACAATTTTTTCG +AATTTTTTTTGTTTTTTCAACTAATTTTTTTTTCTGAAAATGCTTTTAGA +ACAGTTCATTTTGTTTTTTTTTCAATTTTTTTCAGACACCCCTTACTCCA +TATCATAAAGCTCGGAAAATTCGGAATCCCATCCCTGAAACTCGATGAGC +ACCGTTCTACCGTGTACTTCTTCGACGGAGGCCGGTGATATCCAGTAGGT +CTCGTTTTGGCCGACGGCTTCAAGGACACGACCGAACTGAAAAATATTGT +TTTTTTTTTCAAAACCATTTTTTTTAGGAAAAAATTTTTATTGAAACGTT +TTTTTTTTAATTTTAAAATTCCAAAAAAACGCAAAAGTGCAAAAAAACTT +GAAAAAAATGTTCTCAATATTTTTTCCGACTCACAATCAAAGAAAATTTG +AATCGAAAAAAATTAATTGTTTTCTTTTAAAATTTAAGGAAATTATTTTT +CTAATTATTTCTTCCAAAAAAAAGTTTAAAAATAATAATTTTTCAAGTGT +TTTTCAAGAGAAAATTAAAAAATTTCAAATTTCAAATTTTAATATACTTT +TTATTTTAAAAACTTGTATAAATCTCCGAATTATATGGATTTTTTTGAAA +AATAAAAAATTTTTTTATTGGAAAAAGAAATCTGATTTTTATAGTTTTTT +TTTTTAATTTGAAAAATACGAATTCTATCACGGCAACTCAAAATTCTGAG +AATGCGTACTGCCCAATATATTTGACGCGCAAAATATCTCGTAGCGAAAC +TACAGTAATTCTTTAGATGACTACTGTAGCGCTTGTGTCGATTTACGGGT +TCAGTTATTTAAATGACTTTATTTTTCGTATTATTTTCTTCATTTCAATT +AATTTTAAAAATTGAGCCCATAAATCGACGGTACCGTAGTCATTTCAGGA +ATTACTGTAGTTTTCGCTACGAGATACTTTGCGCGTCAAATATGTTGTGT +AGTACGCATTTTCAGAATTTTGAGCTGCCGTGATAGAATTCGTATTTTTC +AAATTAAAAAAAAACTATAAAAATCAGATTTATTTTTCCAATAAAATTCG +TCTAATTTATAAAAAAAAATAAAAATAAAAATTGAACAACGCTGAAAAAT +CCCAGATTTTTTTTTCTTATTTTTTGAAAAAAAAAACTTTTTTTGGAATT +TTAAATTACATAATTTTTTTGGTTCAATCAATTTTTTGGTTAAAAAGCGT +TTTTTTTTCCTTCAAAAAAGCACCTCAAACATGTGCCTTCTCTCCTTGCT +CGGCAACGGCCTAAGCATCTCATCAGGAATTTTTTCCGCCTGCTTCTCCT +TCAAATACCCTTCCCACTTGAATTTCCCGGGCTCAGTGCCTGCAAGCCGA +TCCAGCTTGATTCCGAACTTCTCAGCATAGCCGACAGGATGCATAAAATG +ATTATCAATATGAATTGGGAAGGATTCATCGTCCGATTCTGTCTCATCAG +GTGAAATAATTAAAAATCCAGGCGTTTTGCATATTTTTCGAATTGTTGCG +ACGCAAAATGACTGGCGTAGGTCGCTGAGTGGATCCAAAAGTTCAAATTT +TTGGCCGACTTTTAATAAATTTAATTTTTCAGCTGAAATGTCAGGTTTCC +CAGCAAAAAGTTGCTCGAAAGTGACGTCATCTTTATGATAACTTCCAGAA +CCTTCTGCGATCCGTCTGGAATGTTCCAAATAACCTTCCGTAGCCTTAGT +CCGTAATCCATTAATCATTGCAAATCCGACTGGAAACAGGAAGAAGCTCG +ACTCATCCACCCAAAACTCGACGTTTTCATGCTGAACCTGCCGATCTTTG +GCCTCTACGGAAGGAAGATCTTCGGGATAATCCTGAGCGGTGACCATGAC +CATCAGACGGCGGCCAAGGATCCTGAGGATCCGTGCGACACGGATTTCTG +TTGGCTCCAAGTAGTTGAGTAGCTCGACGCGTTGATTCAGCCGGAAACGA +GATGGGCGGTGGGCAAGGTGGCGGAGTTGGTCGAAGATTTTTGGCTCAGA +GATTCGATTTTCGTGCAGCTCGGCTTGAAATTCCTGCAGGAAAATTTTTT +TAGGAAATGGGAAAATCAGAAGGGTTTTTTGGAGTTTTTTTTCAGTATTA +TTTTTTTTGTTGTTTTTTTGAGGCTTTGTTAAAGTTTTTAGGTGAATTTT +TTTTGTTGATATTTTTGGTTTGTTTAAGAATAAATCATTTTTTGAAAAAA +ATTCGTTTTTATATTTTCGGTTTTTTGCTGGTTTAGTTAAAAGTTTTTTT +TTCGGATTTTCAGGTTTTTTGACAAAAATTGATTTTTTTTTTGGTGTATT +TCTTAGGTTTTCGGGTTTTTTTTTTGGTTTTTGACGAAAAATTTATTTTA +AAAAAAACGGACTTTTTTGCAAAAAATATGGGGTTTCTTAAAAAAAAAAA +TTTCAATTTTTTTTGTTGGATAAAATTAAAGTTTCTTTTATGGTTGATTT +TTCGCCTTTTTTCACATTCTCCACCAGAAAAAACATGAAAAAAACCAGAA +ATGAGTAGTTTTGAGCAATTTTCAGGCAGTTTTTCCGCTCAGAAAATAAT +TTTGGCCGGATTTTCATGGTTTCTCACATCCAGAATCTCCTCTGTTGGCC +GTGGTACGGGCGGTGCAGGCGTAGATCCACGTCGCCAAAATTTCGGGCAT +TGCATCGGTTTCAGCAAGCTCAGTGGCCTGTATTGAAGCCATTTCATCGC +TGGATCCTGCTTGAGACCGCTGAAATTTCGCGTTTTTTTTTGGAAATTTT +GTTGAAAAATAACCTTCCAATATCGAAAATATCCTCTGAAAGCATATGAA +ACCAGCAGGGTCTTCTATTAAGTTCCCCCACAAATTTAATTGCCACGTAG +AAGCCGCAGACAGCAGTCACCTCGCCGAACCAGCGGATTTCTGGAGATTT +AGTGGTTATAGAAGGATCCAGAGACGGTCGGACGACTACTTCTAGCTGAA +AACATTAAGATTATGGCTTTAAAGTTTTTTAAAAGAAAAACCAACTCGAA +ATCCAGGTTTTAGGTGCTGATTTAGCTTTTCCAGCGGCAAACAACCCTCC +AGCGCCTCGACAGGTAAAAATTGAGTATTTCCATCATAATTACATCGGAG +TTCATCTGACCATGTGAATGTTCCTTCAATTTGTGGCTTTGGAATCCGCT +GGGCGATTTTCTCAACTGGATTTCTTCGACGATAGAATAGCCGTTCTTCG +GTGAAATATCGGTATTCTGCTTCTTCAAGTTTGTAATTATATTGACGCTG +AAAGTAATAAATTATGTTTTTCGATAAAAATGCTTTTAAAATTACCTTTT +TATTCGAAAAATTCATTGATTTTAATTAAAAATCTATTTAAATTGTTTAA +ATTAAAAAGTTCCAAGCTTCTGTAGTTATCGCGTCGAGACCCAACACACT +AATTACCACATGCGCCTTTATATAAATTTTAAGAAAATCAACATTTTAAA +AGATTTTTACAGTTTTTTTGTCGTTAAATTTTTCGAAAAAATGATTTAAA +CTCACAGTAAACTTGTTTGAAACTTGAATATTAAAATTTCACAGTCAATG +GGTTAAATTTCAAGACTTTCCCACTGATGATACGGTAGGCGCGAAGTACG +GTAGTTTGTTTTGTTTTTTTTTATTTTGCCGCCGAGTGATTCAAATTTGA +ATTTATATCATCCGATTTTTTGATTTTTTCCTCAATATTTCTCGATTTTT +CAGCTTTCAGTGTGATTTTCCAAGAGCCGTAGCTCGACCAGACGACGGAG +AGCCTGAGGCTGGTCGCCAGAAGCACTATGAAGTGTGGGTTTTTTTTAAA +GCATAATTTGCATTAATCTTCTAATATTTTAGCCACCCCACACCGTCCAC +GAACAAACTCCGAATCGAAGCTCGGGGCTCGCGAGCAGCTTCTCCGGGAC +TCTATACGAGTGGGTTTAAGTTCTTAATTTCAAATTTCACTCATTTAAAA +ATTTTATTTTTTAGCTTCAAGTAGCTTCGGAGCCGTACGTCCACATGACA +AAGGAATCCACGTGGGACGAGGCGAAAAAACTGGCGATCAGTCTTGAAAA +GAAGCCGGACATTGTCCGTAAAGCGATATACAATCGTCGTCGCTTCGTCA +ATGAAAAGATAAAAAGTGCGCTGGTCAAGCGCGAAATCATCGACCCAAGA +AGCCCGGCAATCCATGAAATAGCAGTGGCGGCGGAGGTATTTTAAAAGAA +AATCAGACAAATTTAATATCTAATTATTCCCCATTTTCTTGCAGACAATC +GCCATAAACGTTGTGCACTTCTTGGAGACTCATCACGCAAAAATACTCGC +TGAAATCAAAGCGGCCGCCGCTGGAGCCGGCGCCCAGCTCCGAACTGCAT +GAATTAATTCAAATTAATATTTTTAAACTCATTTTTCACACAAATAATCA +TTCATGTGTCCATTTTTCACTCTCGAAACCCATATACCCTCACTCTAAAT +ATCAATATAATGCACATTTCTCATAGTTTTAATCTGCCCTTACCAATTAA +ATCTTACCAATTTTCCGCCATGATCCCTTTTTCCATTTTGAATAAAATTC +GACGACGATTTTTCCATTAAAACAAGAAATATATAAATAGATTCAAAAGT +GGCGCTTGTGTCGCTCAGCGGTCTCCTCCACTTGCACACTATCTCACCGC +GGCCTTCCAATTACTCGTCCATTTTCCAGCTGTAAAAAGTTTATAAAAAC +TGAAATAAATGCAATTTTCAGCAGAAAATCGCTGAAAATGCGGCAAATCG +TCGAGCTAAAGTCACTTTTGACTTCGGAGCCAATTAAAGCCATCGAGCTC +TTCGATAGGCTCGTTGGACAAGGTTTGAGCCGAAAATCTAAACTTTTAAG +CTGAGATTTCTTTTAAAAATCCCTTCCAGATGCCGACACAATCACCCAAG +AAGCCTGTGGAACCCTCGCCAACTATATCCGGCATTCCAGTGTTTTTAAG +CGACGGCTTCTGTTCACGGAGCTCCAAAAATGCTCGTTTTTTGCGAAATT +GTGCATTTCGTTTCAATTTCACAGCTTTGAAGACACAGTTTTTCCGCGAA +AATTGATTTTCGAACGATTCAGCGTGTTTTGCGGTGAACTGGAAAAGGAC +AAGCCACGTGGGTTTTCATTTATTGAAAATTGAAAAGATTTTTGCAAAAA +ATCATAAAATTTAATGTAAAACTGAACAAAACTCGATTTTTAACCGAACC +TTTTTGTTTTTTCCGTGAAAAAATCGGTTTTCCAAGTTTTTCGAACATTT +TCCGAAAAAAAATTACGCAAAAAAAACGATTTTCAAGTAACAAATCCGGA +AAAATCAAACTTAAATATTTTCGGAAAATTTCATAATTTTCTTCAAATCT +CTGTAAAAAGTAGATTCGATTTCTGGGAAATTTGAATTTATGTCATTTCT +TTAAAAGCGCATGCTCTTTTGTAGGGTCTCGCAACGAATTATTCAATTTA +AACTTTGAAATTCGCGCCGAAATTTGGGTCTCGGCGCGATTTTTCGAAAA +ATAAATGAAAAATATGTACTATTAATTTTTTCTTGAAAATTATTGATTTT +TCAGATCACCGGCACCACGTCACCGCTGTCGGATCGAATCGTTTCTTCAA +TTTGGGACTACTTTCCGATGGAAGCCCCGTCTCAGAACCCCGACTGGTCC +CCGTGCCACGTGTAATTCAAATCGAGATGACAAATACACACACAATATTT +TTGACTGCTGAAAATCAGATTTACGGCTGCGGAAAAGCTTCATCTTTTTT +GCCGGATAAAACGGAGGAGACGGACGGTGGTTATGTGGCACTGCCCACTT +TGGTAGAAATTCCAAAAGTTACTGGATACGTGGCAGCTGTGAAGGTGTTC +GATGGAGGATCACAGTTTTTGATTGGCGGCAAAGTACGGTTCTAGAAAAT +TGGTGGCCGAGTATTTTTTCGCGGCCACATGGCGATTTTCTACACGAAAA +GTTGTGTAAAAGACAAAAAGGTGTGCGCCTTCAGGGATTACTGTAGCTGA +AGTTTTTCATAGATTTTTTTTTTGGCTTTAAAAAAATCCTTAAAGGTGCA +TTTTCGTGTCGAGACCTTGTTGTATTATTTTGCTAATTTTGCTTAAAAAG +TACAGTACCAGGTCTCGACACGAATAGTTTTGATAAATGCAAAAATGTGT +GCGCCTTTAAGGATTACTGTAGTAAAAAATAAGAATCCCTTTTGGAAAAT +TTGATAATTTTGTGAAGAAAAATAGATAATTCTTTGAAAATGAATAATTT +TTTGGAAAAATCTTTTTTTCTTATTTTTCTAGACGTACACCTTTATTTCA +TTAAAAAATTGTCGCGCCGAGACCTGATACCGTATTTTTGAGCGCAAAAT +CGTGCCGAGACCCAAATTCGTGAATTCAAATTTTCAGTGGTATTGTGTTG +GAAAATGTTCGATTTCCGGAGAAACGCGACGAATTTCGTCGAATTGTTTT +GTTCTGGTAGAGGAGGAAAACGAGGAGAAATTGGAGAAAATGACGAAAAA +TATCGATTTTTACGTGGCAAATGTGCCGATTGAGGAAAGGATTGTGAAGG +TGGATTTTTTTTTTCAAAAATTTGAAAACAAAAAAACTAAAAAAAAAAAT +TTTAATCTTAGTTTCTAGAATTCAAGCCAGTTATAATAATTTTTAAACTA +AAAATTGCATCTTCCGAATTTTCAAGATTTTTTTTTCTGAAAATCGTTTA +AAAAAATATCTTGAAAAATCAAAATTTCAAAAAAAACAAAACTTGAAAAA +AAAAACGTCTTTAGCGGTATTTTTTCTATAATTTTTCAATTTTTTTCAGC +TTAAAAATCATAGAAAATCGTAATTTTTTGACATTTCTTCCAGGTATATC +TAAAAATGGACCAAAACGAGATTCTGTGGGATAGAACGAGCGATTTCTCA +GCGGAAAAGCCGATTTCCTTCATAATCAATGGATTTCCACAAATGGCAAT +TTTCGAATCATTTCAACTTTTAAATGATGGAACTATTTATGCTGCGAGAA +ATTCACTTTTCAAAGGAAAATTGGAGCTATGGAAGAACAAAGATGACGGG +TTTAAAGTGAAAAGCGGGACTGTTTTGGAGCATTTTGACACGAAATATAC +ACTTATTGCACTGATGGAAGAGGTTCCCGGTACTATTGGAACAGAGTTTT +TCAAAGTTTCACCAGATGGGCAGAATTTGATTATGAAGGTTCATTTTGTT +TGGAATTTGAAGGAATTCGACCTTAAAAATATAAAAAATTGCACTGATGA +TGTTATGGATTTTTTTTTCAGAAAAAAAAAAACGAAAAATTGAATGCTAA +ATGACAGAAAATATGCCCCTGTAACATTTTTTTTTTGAATTTTCTAAATT +TTAAATTATTTTTTTCAGTTTTGCGCAAATCAAAGAAACGGCCGAATTAA +ATTTGAATTCCCGCGCAAAAGAGTGACGTCATTTTTTTTTTCCCGTTTTC +CGGATGTATTATTAGGTTTTTATTTTAAACACAGTTTGTCAATTTTTCAG +ACATTTTTTTTTAAACTTGATAACCCGAAAAAAGTGGCCTAGAAATCGGC +TTTACAATTTTTTTTTTAAATCGACAAACTGTGTTTCAAATTATGAAACA +AGGAAAAAACGAAGAAAAACTTATAGCCGGAAAACGCGAAAATGTCGAAA +ATGACGTCACTAAATTGCGCGGGAAAAAATATAGAATTTTTTTTTAATTA +ACAGCTATATTGAATCATTAGGGCTTGTTCTCCGTCAAAAAATTTCTCGA +AAAAATTGATTTTTCGTTTTTTTTTGGAAAATCGAAAAATTTTGTTTCTC +AAAAAAAACAAAATTGGAATTTTTATTAAAAAATTATTTTAATCCAACAA +AAAAAACTAAAATTTTTTGCAAAATTTAAAAATTCATAAAACATTTAAAA +AAATTTTTTAAAAGTTATATTGGGACTGTATTCTAATACTTGGACTAAAA +AAACCCACATTTGACAAAAAATTCAATTTAAAATGAATATTTTCAGATGG +GCTACCAAAACGAACAGAAAACCGAGAAATTCGAATTCGAGTCTCCCAAA +ATTCACAAAATCATCAAAAATCGTGAAGTACAATGTGATCCAGTTGATAT +TCCGTTAGACTCGACTATTCATTTTCATCAAAATTATAATCAAGAAGTAT +TGAAATTTCAATCGAATCGATTATTATTTCAATGGATTTATCCGAATTAT +TTGTTTCAAAACGATGGAGATGTACATTTTTCAATTGAACAATTGGAGAC +TGTATTTGCTGTGGATTTGGAGAATTTGGAATTGTGAGGGTTTCTTTTAT +TAATTAAAATTTTTTTAAGTGGAAAAATTTTGGTTTTCTTTTCAGAAATT +ATTGTAATGTTGTAACTAAATATTACGGGAACACGAAATTCTAAGAATGC +GTATTGCACAACACATTTGACGCGCAAAATATCTCGTAGCGAAAACTACA +GTACTTCCTTTAATGACTACTGTAGCGCTCGTGTCGTTTTACAAGCTCAA +TTTTTTAATACTTTAAATTAAAACTTTTACTTTAAATTTTAAAAAAATTC +GTCTTATTTTTTAATTTTTGCTTTATTCCAATATTCTGTCGATAAATAAA +TCATTTTAATAAATTTAGAAAATTGAGCCCGTAAATCGACATGCGCTACA +GTATCCATTTAAAGAATTACTGTAGTTTTCGCTACGAGATACTTTGCGCG +TCAAATATGTTGCGCCGTACGCATTCTCAGAGTTTTGTGTTCCCGTAATA +TAGAAAATTAGAAGTATGTTAAAATTTTTAAAAAGTATTTTTTTTGGACT +TTTACCCAAAGATTTTTTTTTGCAAATTTTTAGTGAAAATTATTATTTTT +TTCAATTCACGCTAAAATTTATTAAAAATTTAAATAATTTTAGACTGTAT +TCTATACAATCAAAAAACAACAAACATCAATAAAATTTTCAATGAGTTTA +AAATTTTTTTGAATTTTTTAAAACTTTTCTTCGTTGACAAAACGTTCACA +AAACTTGAAAAAATATATTTCAAATTAATACTTAAAAATTCAAACAAAAA +ATTTTTAAAATTTTTCAGCCCGAAATACCAACCTATATCACCAGAAGAAT +TCGTTCCCACCGACACTTCTCCCTCCGATATCTGGTATTTAAAATCCAGT +GAAAAATTGAAAATCCCTTGTCACAAGTACCTTCTCCTACTACATTCACG +TCAAATTGGCGCGATGCAGAGATTTCATTCAAATTATGGGAATTTCGGCG +ATTTTAAGGATGGTAAATCTGAAAATGAAGTGGAAATTGAAGCGAATGCT +AGTGTTGAAACTGTGAAAAATGCGCTGAGAGGGATGATCAATATTCGAAC +TCTTTTCAAAATTAAGACTATTGAGGTAATTGGATTTTTGGTGAAATTTG +AAATGAAAAAATATTTATAAAAATTGAATTTTTTTTCAAATTTTTTTTTC +AGTCACCATAAGTCAATTTTCCATTAGATAAAAATCGATACTTTTTCTAA +ATGCGATAAAAATTGGAAATTCTATAAATTCCGGAAAAATCGATTGATTT +CAAAAAATCGATAATTTCCGGAAAATTGATAAATTCCAGAAAATCGGTAA +TTTCCGGAAAAATCGATAATTACCGGGAAAACCAATTAATTTCCAGAAAA +ATCGGTAATTTCCGGAAAAATCGATTGATTAAAAAAGTCAATAATTTCCG +GAAAATTGATAATATCTAGAAAAATCATTAAATTCAGGAAAAATCGATAA +ATTCCAAAAAAAAATCGATAATATCCTGAAAAGTGAATAAATTCCTAAAA +ATCGATGAATTTCATCAATTCCGGGAATATTTTTTAAATTTAAACTTTAA +AAAATATTTTTTTAAATCTTTAATCCTTATCTATTTTATTCAAAAAAAAA +CTGATCAAAAAAATTTTTTTTTTTCAAAAATTCAATATTTTTGCAGTTAA +TCGAATGCATCAACTTCTACGATTATCATTTAATGGATGAAATGTTCAAT +GATTCAATGCATATTCTAATGGAAACAATCACTGAATTCACACTTCCATT +TCTCTACGAATTATTCTATTCGTTTGAGGAAAAAGTGTTGGAGGGACTTT +TGCAGAGGAAATATTTGATTTCTAACTCAATTTCCAGTGTTTTACCGCCA +AAGGAGCTTCTTGTACGGTAAGTGAGTTAAGAAATGGAAAAAAACACATT +TTTGCTACTGTTGGAATTTTTTTTATTTCACAAATATATTTTTTTTCATT +TTAAAGTTAAGTAGGAGTTTATCAACTTTTCTGGATTTCATCAATTTTTC +CGAAATATTTTGATTTTCCCGGAATTTCTGTGTTTTTCAGGAAAAAAACC +CCAGAAAACTAACAAAAAGAATTAGCAAAAATGACCTAAAAACCGTAAAA +CTATGTATCCCAACTTGTCCACGTGTAGTACAAAAAACCGATGTGCACCA +ACAAGAATTTTTGCAAAAGCTATTTTTCCATTCAAAACTGCGCCCCAAAC +AGTTGAAATTTTATAGAAAATTTTCGAAATTCGCTTCTCCGAAAATAAAA +ATCTCAGATCCGCCCATTTCTTGGCTCTTCCAGATTCGCTGAAAAACTGG +ACACCGATTGCCGCCGACACCACACATTAAAAGTTCCGTCGAAATTCAAA +AATCTAGAAAATCTGAGCACCTATGAGCCCGAGTACATTGTCAAATATTT +TCTGAATCTCGACCAAGATTCGGAGGATGTGACGTGGCGATCGATACGTC +ACGAATTCCACGACACACTTGACACGTGGCACGCGGAAGCTGTGAAGAAG +AGAGATGAGAGACGTATGCACGGAGCAACACGGAGCAGAACGAGTAGTAT +TCGGAAGGAGAGCTTTACGAAAATTCAAAATGTTTCGATGACGTCATCGC +CGGTAGGAATATCGATTTTTATGTATCGAATTTACTGGAAAACTATCAAA +AGTTTAGGAAAAATATCGATTTTCCTGAAATTTATCGATTTTCCTGAAAT +TTATCGATTTTCCTGAAATTTATCGATTTTCCTGAAATTTATCGATTTTT +CTGGAATTTATCGATTTTTCTGGAATTTATCGATTTTCCTGAAATTTATC +AATTTTTCTGGAATTTATCGATTTTTCTGGAATTTATCGATTTTTCTGGA +ATTTATCGATTTTTCTGGAATTTATCGATTTTTCTGGAATTTATCGATTT +TTCTGGAATATATCGATTTTTCTGGAATTTATCGATTTTTCTGGAATTTA +TCGATTTTTCTGGAATTTATCGATTTTTCTGGAATATATCGATTTTCCTG +AAATTTATCGATTTTTCTGGAATTTATCGATTTTCCTGAAATTTATCAAT +TTTTCTGGAATTTATCGATTTTTCTGGAATTTATCGATTTTTCTGGAATT +TATCGATTTTTCTGGAATTTATCGATTTTTCTGGAATATATCGATTTTTC +TGGAATTCATCGATTTTTCTGGAATTCATCGAGTTTTCCGAGATTTATCG +ATTTTTCTGGAAATTTTACTCCCCAAAAATTTAACAATATATCGTGCCGA +GACACGAAAAACTCTAAAAATTACAGATTCCAATCGGAGGCGGCCGCTCG +AAACCCGAAAGTTTCTCAAAATCAATCAATAGTCCTGTCATTCAATCGCC +ACTCTCTCCCTCACCAATCAAAGGAATGCCAAAGGTAATCGTGTCGAGAC +CCACCACGCCACCTGCGCCTTTAAATTCCACGTTTTGTAGTCCCGCCACG +ATAGTATTTCCAATTCACTGGACGATTTTCCTGAAATGAGCATTTCACCG +TCCCCCTCGACACCGAAATCCTCTTCCGGTGGCGGTCGCTTCGCACCAAA +AGGAACTCGATTTAAAAAGGATTTCGAAATTCTCGTGAAACCTTCCCAGT +CACCACAGAATCCGTGGAAAATGGGCGGAGCTTCCGCGTCGATTCGCGAA +GAAATTGATCCGCAGGAGATCCGATTCGACGAAGTTGTGAAGAAGGAACA +GAAATTGCAGACTAATATACGTGCGTCACTTGAAATTTTGGAAAAATCGA +TAATTTTCAAAAAAATCGACCTTTTTTTGGAAATTATCGATTATTCTTGA +AAATTATCGATTATTTTAAAAAATTATCGAATTTTCTGAAAAGGATCGAT +TTTTTCGGAAAAAGTTTCGATTTTCTCGAAAAATAACGACTTTTTTTTTG +AAAATTATCGATTTTTAAAGAAATTATCTATTTTTTTGGAATTTATCGAT +TTTTTTTAGGAAATTATCGATTTTTTTAAGGAAATTATCGATTTTTTTAA +GGAAATTATCGATTTTTTTGGAATTTATCGATTTTTTTTAGGAAAAAGTT +TCGATTTTTCTCGAAAAATAACGACTTTTTAAAAAAAATTATCGATTTTT +AAAGAAATTATCTATTTTTTTGGAAATTATCGATTTTTTTTGAAAATCAT +CGATTTTTAAGGAAATTATCGATTTTTTTGGAATTTATCGATTTTTTTAG +GAAATTATCGATTTTTTTGAAATTTATCGATTTTTTTAGGAAATTATAGA +TTTTTTCTGAAAAATTATCGATTTCTCAAAGGAAAAGTATCGATTTTTGG +AAATTATCGATTTTTAAGGAAATTATCGATTTTTCAAAAGAAGAGTATGG +ATTTTTTGAAACTATCCATTTTTCTTTTAATTATTGATTTTTTTCCTGAA +AAATTATCGATTTCTCGATGGAAAAATATCGATTTTTCTGAAAATTATCG +ATATTCTTTTGGAAATTATCGATTATTCTAAAAAAAATTATCGATTTTGC +AGGAAATTCTCGATTTTTAAAATAAAAACAGCGATTTTTTTTTTGAAAAT +CATCGATTTTTAGGGAAATTATCGATTTTTCTGAAAATTATCGATTATTT +CTTCAAAATTATCGATTTTTCGAAGAAAAGTATGGATTTTTGGAAACAAT +CTATTTTTCTTCAAATTATTGATTTTTTTACCTGAAAAATTATCGATTTT +TCTGAAAAAATATATAATACCACACATTAATTTCAGGAACCGGATTCAAA +AAAGTGCAGCTTCTACCACACGTGGAGACGGAAGAGCTCGCCGGAGCTCA +AATTTTGGAGGTTTTTCGACGAGAACTTCACGATGAGGCGCTCATATGTG +TAGGAATTTGTGATGGTTTTTTTCTCAAAAATTTGAAATTTTTCAGGTGG +AACTGGTGATGAGCGACGATTTGGAGGTGGAAAACGAGCAGATCATCTGG +GGAAACATGCCGGGACTTGTTCGGCGTTAAATTTTAAATTTTTGATTTTT +TTTTTTCTTGTAACTTGCATTTTTTGTTTAATTTAGTGTTTTCGGTGTTT +TTTGTTGAAATTTTCGGGTTTTTAATATTCAAAAATTAATTAAATTATTA +TAAAATAAATGCATTTAGAAATGCGGTATAAATTGAAAATTTTCAAAAAC +CATCTCCCCGAATCCAGTGGTTTAGGATGAAAATCGTGGAAATCGAGCCG +AACGAGAGAATTCCGAGTTGCCACGTGGGTCTGAAAATTGAGTGTATTTA +ATTTTGGAAAATTTTGGAGATCTCTTACATTTTCTCAAAAATCCATAGCT +TTTTCCCATTTTTTTGTTGCTGGATCATTTTCAGCTCTTCGGTTATATCG +CAGACTTTGAAGCAAGGGTCTTCCGGGAGAATTTCCTGAACATTTGAAGT +TTTTGGGTGAAAAAAAAGCTTTTTTAAAAGATTTTTTGGTATTTTCAAAT +AATATCGGAAATTTGCGTTTAAATTTTTTTTTTCAAAAAAGTGAATTTTT +TCAAATTTTTCGAAAAATCGAAAAAAAAATTTTCGGGTTTCTGGAAATTT +TAATTAAATGTGTTTATGATGATGAGAAAATATAGTTGACAAAATAATTT +TTTCCGATTTGTCAATTTTTCAAAAAATTTGAAAACAATTTTTTCCATTT +TTATTCCTGAACATAAAAAATTCGAAAAATTTTCGTTTTTAATAATATTT +CGGAAAAATTTTGAATTTACCGTAGTTGTGTCATTTTTAAAGAAACTCAC +AATATTTCTAATCGAAGTATGCATATTTTTTAAATGAATTTTTGGAAAAA +TTTCAAACTTGTTTTTTGTTGAATTTTTCGATTTTCTTTCGTTTTTTTAA +ACAGAACAAATTTTTCATCATCTTTTCTACAAACAAAACAAAAAAAACAA +TTTTTGTTTTTAGAAAAGCGAGAAAAATTTCGAAAAATTATTTTAAAAGT +TAGAAAAATATCAATTTTGAACGGAATTTTTTCAAAATTCGATTTTTTTG +TTTATTTTTCTAATATGTTCAGTTTTTGGCCATTTTTTTTTTTAAAAAGT +TTGCTTTCAAAAAATTTTAAATGAGAATTTAGATTTTTTAACGAGAAATG +TTGAAATTGAGAAGAAAAAAAAAATCAATTTTAAATAGAAAAATTTTCTT +TTTCTAACATTTTCAGTTTTCTCAAAATTCCAAAAACTCGTACATCCTCC +TGACAAGTACAGTAATCCATTGGATCCAGATTCTCCTCTCCAACACTCGT +TTCCCGAATTTTTTCGAACCAATTGTTCATTTTCATAAGAACCGAGCTCA +TCGCAATCAATTTCCCGATATTTCCATCGTATTCCTCCGAAAATTGCTGA +AGCCGATTCAAATTTCCAATATCATGCTGGTGGAGAGAATACGGAGTGTT +CAATAGATCCGTAATTGATTTAACTTTAAAATTTGGTTTTTTCATTGTAA +TAATCATGCTAATCGTCTTGACATGATCTGTTAAATTCTCTCGTTTCGGC +GGAGAATATAATCGATATTCCAGTGGCACGAGGTTGTCGAGAAATCTATT +GAAATTCTGATAAATATCGTTCCAATCACTTCGAAGCTCGTCAGTTTCGG +CTCCAGCTCCGCTTTTGAAGCCAGTCGTTTTTAGATTGTGCTCCAGCGTG +TCTATTGAGCTCTGAAAATTTGATTTCAAAAATTTTGAGTAACTCAGACA +ACCCCATTTTTCATCTAATTCGAAATTAGCCACATCTTATAAGAAATTAA +CCACATCTAATTAGAAAAAACTTTTCTAATTAGAAAGGATGCATATCTAA +TTAGAAAAGCTGCACACCACATCTAATTAGAAGGGATGCTCGTCGAATTA +GAAATGAGGCACATCGAATTAGAAAGGGGGCGCGTTGAATTAGAAGTTAT +GCGCATCTAATTAGAAAGGAGGCACATATAATTAGAAACACATTGCGCAC +CACATCTAATTAGAAGGGATGCTCGTCGAATAGTACTACCTTTTAATGTA +TGTACTACCTTTTAATGTATGTACTACCTTTTAATGTATGTACTACCTTT +TAATGTAAGTACTACCTTTTAATGTATGTACTACCTTTTAATGTATGTAC +TACCTTTTAATGTATGTACTACCTTTTAATGTATGTACTACCTTTTAATG +TATTACCTTTTGGCTCTTAATGTTGAAAATAAATCGAATCAAATTAGAAA +CAATGCGCGTCGAATTAGAAAAAAAGCATGCCGAACTGGTGCGCGTTAGT +TGACCCTATTTTTCTAATTAGATGAGAGGAATAGGGTTGTCTGAGTAAGA +CTGCAAATTATCAAAATTTTTTGGTTCAATTTGTTTTTGGAGAAAAAAGT +GAAATTTCCTGGCAATTTTCAGTATTACGTAGACGTCGAAATATGAGATT +TTTCACCATTTCTTATGGGTCTCGCCACGCCGACAATCAATTATTGTAGT +TCATGTCGATTTACGGCGCCACTGTTGCATTAATATTCCAAATGACAAAT +TTGCCGCCGAGTTTAAAAAATTCAATAAAAGCCCGTAAATCGACATGAAC +TACAGTAGTTGGTTGTCGGCGTGACGAGACCCAATTCTCATCTTTCGACG +TCCACGTAATATAGAAATTTTTTTTTTGAAAAAATCAAACGATTTTGCCT +CAAAAAATTCAAAACTGTAAATTCAAAAAATACCACAAAAAAAAAGCGAA +AAAAATCGCGGAAGACAGTGGCGCCAGGCTGTCTCAATACAGTTTGATCT +ACAAAAAATGCGGGAATTTTTTCACAGAAAAATTGTGACGTCAGCACGTT +CTTAATCATACGAAATCAGATGAGATTTCTGCGTCTGCCATCCCGCATTT +TTCCAAGATCAAAGTGGAACTGGGACTTTCTGAATAGGACTTTCTGATTC +CACGTGGGAAGGATGACAAATCCAAAATTGCGATATTTCACTAATTTCAC +TGCTTGAATTTCCTTGGAACCAATCAGCGTCTTCAAACTCCGCCCACTCC +ATCTGATTGGTTGAAAAATGGGCGGAGCAAATCGCTGATTGGTCGCAGTT +CTCATTTTTAGCCAAAGTTAAAAATCTCGATTTTTCAAGGTTTTTTGACC +ACCTCCAATTCCAAGCTTCTTCCTTACCTTCAAATCGTAGAATATTGCCA +ATTCTCTGATTGCATCGAGTCCTTCCTTCAAAACCACAACATCTTGCAAC +TCGAACCCCGAAAGCTGATATTTCTCGTTTAACTTGAATTCTCCTAGAAT +ATCCTTCGCACGTAGCAACTCTCCAACGATTCCTTCAGTTGGTAGAAACT +CTTGTAGAGTGTACACTGCCTCCCAGATCTTCTCAAGATCCCCGTAATTC +CAGACATCTTCCGAGCTAGCCACAAGAAATTGCATATGTTGGTGTTTTTC +GTTTCGAGCAACACATTCCAATGAGGATACGAAGTTAGACTCGTTGATTT +TTGTTAAAACGTTTATCATGCTGGCGTAGATTTCCTCGAATTTGGTTTTT +CTTTCTTGAAATTTTTTGTATAGTTTTGAGGGTACCATACAAAAATTCTC +GGGAAACTTTTCGATATCATCTATCATCATCGTCAGGTTATCGAAATCTA +TATACTACAGTGTTTTTTGAAGAGTTTCCACGATATTTTGATCGGTTTGA +TGTTTGAATGCTTCGAGAATACGCTCGTCTCCGCAACGTCTTAACGTAAT +GCAAGGCTGTGCGGTGTGTACAAGTGTCTTGTTTAGCTCTTCAAAACCGG +AGCGATACATAGAAATGGTTTCATGCGCAGCGTCCAGCTGCTCAGGGCTC +TTGAAAGTTTTCAAACATTCCGAGAAGCTCTCAACAATGCTGTTGAGGTT +ATCCTTTGGCAGATTTTCCCGAATTTGATTAACTTCTGATAGATATTTAT +CGATATATTCGATATTTTTATGATATTTTTCCGTGTTGTTTAGGATTTTT +TGCATCGCAAATTCGAATTCCACATAGTATTCCAAAAACTTATTCAATGG +ATGCAGGAATTGAATTGATCCTTTGCCAGAAACGCTTTTTATCCAATAAT +TGCTCTGCTCTTTTATGGACTCTCGAATACTTTCTTCTCGTTTAGGGAGA +CCTAAAGCTCCACGATCAATTCGTTTTTTGAAAGAAATAATTCAAAAATA +CCCAAAAGAAAATTGCCTGATGGCCTGGAAGAATGCGTATCCGAGGATTG +AATACTACGAATAACGTCCCTGACCTTTCGCACCCAATTTGAAAGCCCCA +GTGTCGTATTGGTGTCGCGAATCATTTCTAAATCACTCAACGCCGCTTCG +AAATTGTTCAGTCTTCCCACTGACAAGAAGTCTCGAACACTTTTACTTTC +ATTTTTCATTATAGTCGTAGCGAGTTTGAAGAGATAAAATGGATCTTGAT +GGAGCAATGCGAATTCTTTCTTGGCTCGTTCCGGAAAGAAATTTCTGTAG +TAGGCGCCAACCTCTTCGACCGTTTCATAGTTCCGTTCTGTACGATCTTA +AAAGGTGGAGTACCGAAATCTGGGGAATATTTCTAAATAACTCCAAATTT +GCTCCTGATTTCAATTATCCATGTGAAAAAATTCAAAAAATCCCTGATTT +TGTATTTCGGCTTGAAATTGCCGAATTCCATTTGTGCACACATGCAAATT +TTTCAAACGCGCGCCCAAAGAAATTATCATTGGAGCGCGTTTGCCTCATT +TGATTCTCTCCGGAGCACGGTAGCACAGAAACTAGATGGATTGGTTCATG +ATACTCAGTCTGGAAACCTATATTGGCTACTATCTCGAAAACCATCATAA +AATCGATTTTGCGATGCAAATAAGAAATGACCGCAATGAAATTATCTATC +TCCATTCGTGATGAATTTTCGATTTTGTACTTCCTGGCCAAGTTATGCAC +GTTTGTTCGGTGGAGCGCGTTTTCACCCATCTAGCAACTGACACGGTGGT +TCAGTAGCCAATATAGGTTTCCAGACTGAGTATCATGAACCAATCCATCT +AGTTTCTGTGCTACCGTGCTGAACCACCGTGCTCCATCTACCGTATTTCT +TCCATTAATATGGCTGCAATACTATTTTTCGATGGTCTTCCCGCTTGCAA +TACTAATAGGGAGTGCAATACTAATTTTCAGAATATTTTTCTGCCTTTGA +GCTTACTAGTTTTTTTCTGAAAAAGCTCGAATTTTATGTAAAAATTCAGA +AAATTGGTTTTAATTGTAACCTATAAGTTTCAAAAATTCAATCTCGTAGA +AATTTTTTTGAAAAATTGTTGCAAAATAGGCAAAAAATATTGTAGAAGTC +CTGAAATTAGCGAGACGGGATTGCAATAAAAAAAAGTAAACGCAAGACTA +TTAGGGAGTGCAAGACTAATAGGGAGTGCCATACTAATTTTCGGAAGGTC +TCCGAGGGGCAATACTAATAGGGAGTGCAAATCTAATAGGGAGGCCATAC +TAATAGAAGAAATACGGTATTTTTAGTTCCTTTATTTTTTCAACGAGAAA +ATCAAATGAGGCAAACGCGCTGCAATGAAAATTTAAATTTATTTGTGCGC +GCATTTGAAAAAACTCATTCGGACGCAAATAATATTCACGAATTTAAGCT +GAAATATAATATCAGGGAAATTTTTTTGTTTTTTTTTCATACAGATATTC +TGAATCAGAGGAATTTTTTTTAGTTATTTGAAAATATTTCCTAGATTTCG +GAAATCAAAACAGCAGCTTTTGTACAACAGCTTTTTTTTAAATGTAAAAC +TTGTTTAAAAGTCAAACCACGTCCATTTTAAAAATTAATTTTTTAACTTA +TAAAATAAAAACATGTGGAATGCTTTTGCATGTACATTTATACAAGTTTT +TTGAGAAAAATACATTTAAATTTGAAAAATGTGTTTACTAAAATTCTGAT +CAATTTTTTTGTTATTATATATTAATAGCTGAACTTTACTTTAAGACAAA +AATTCCTCTAATTAAAATCTACCTTCAAACCATTTTTTCAGTTTTTGCAA +ATTCTCCTCGGAAATCGCAGTAGGACTGGGAGCTAGATCATTGAGTGGCG +AGAGAAAATCACGGAAATTTTTCAGGCGATTTTTCAGGCCCCATGTTGCC +TCCCATCCGTATTTTGGTTTCATGAGAGATTGGAGATCATGAAATAAATG +CAAAAAAGCATCCAGCGAGGTGGTGATCTTTTTCAGTGATTCTCGCTGTA +GTTGAAGATGTGGGAGCTTCTTAAGTAAATTTACAGCTTCTTCTCTATCC +TTATAAACTTTAGTGTTCTTCCTTTTCCCGACAATCTCCTCGAAAGCTCT +CTGCTCATCCCATCCGCCAATAGATTTTGTTTTGTAGAAACTTGAAATCC +TATCAAAATCGATATCCCGATCTAATAGCTGATTCGTCAGATCCGTAGAA +GCGATTTCGCCGCTGAGAAGCCCATCGACGATAAGATAGCAGTTAAGGAG +CGGTGGTAGTGAGCTCATCCAGTGAATCCACAGGTTTATGGAGTCCTTTC +CGTAGACTGAAATTATTTTTAATATTAAAGTAGAAAAAAATTATTATATA +AACTAACTATACGCAGGAAAACTCGCATTAAGTTCCAGATTTCGATCGAA +GAATTGTGGATGTCCAGCTGGAAATTTTTATTTAAATTTAGTAAATTTAG +TGAAGAAATTTAATTTAAAAATACCTGTCAAGCGCTGACCCTTAATCTGC +TCCAACATTTGAATACCTTGCCGCTCCCTTTCCGAAATTTCGAGATCTCC +GCAGTGTTTACCCGGTAGAAAAACAAGAAGAAAGGGAATTATCGTTATAA +TCATCGTTATCTGGAAAAAAATTAATTTTCATGGAATATATTTCAAATTT +TCGACAACCAAACGCTGAAAATTCACATTTTTTTCAGGAAATTTGGTTGA +AAAATCTGTTTTTCATAATATTTTGAGAAAAAAACAAGCGTAAAGGTATT +CAAGGCGCATGCAATTCACTTAAGCCAGGGTCTCGAAGCGAACAGAAAAC +ATACGGTATTTGAAAATATTCTTGTTTTCCGCGGAAAGTCGCAGAATTTA +ATTTGATTTTTTTAACTTAAAAAAACAGAAAATTAACCGTTATACCTTTT +GAGCAAAAAATTCTACAAGATAATAATTTAAAACAATTAAAAATTGAATA +AACATTGAAAATTAAATGCTTAAATTTCAAGGCGCGTGCATCAAACTTTT +GTTTGGGTCTCACACCGAATGTAACAAGTACGGTAAGAGTGCGCGCTTAT +TTTCATTTTTCGAATTTGTGCGACCAGTTCTCATGTTTTTTAAACGATTT +TTGCGGTAATTTTGGCCATTTTTTCTAGTTCCCACCGACAAATTGCATTA +TTTCCGTATTTTCAACGAAAATTTTGTTAAAAAACCAACAAAAATTTAGA +AAATTGCATCATTTTGCAGGGATGAATGGTCAAGCGGATCGCTGCGACCG +AACCGCCTACGTTTCGGGTCTTCAGCCGACAATCTCCGACATAGAACTGT +TCGAGGTGTTCAATCGTGTCGCTCACGTCGAGAAGGTCATCGTTCGCAAT +GGAGCCGCCCGTCACGCGCTCATTGTTTTCAAGTTGGCATTTTTTTTCCA +TTTTTCCTCATCTAAATCTCTAATTTTCCTATTTTCAGAACTGTTCAAGG +CCTGTATCAGGTGCTCGTAAACTTTCAAGGAACAACTCTTCACGGCCGTC +AGCTGCACATTCGTCCACTGCGAGAAAGTTCGCACGCGAACAGCGAGGCC +ATCTCAACGATGTTCGAGAAGGTCAAACATCAGGGAAATTCCGGGAATTC +TTCGTATCGTCAAGAGCACTCGTTCCCCGAGTACCGAAACCAGAACCCAC +AGGCTTCATCATACCTTCCACCGAATCCACGTGGTCATCGAAACTCGACG +GGCTGTTTCAATGGTGGCGGCGGGGGCTATGGACGCCGACGTTCCGCCGG +TGGATACAATCAGTACAATCAGAACAAGTATCCGAACGAAACGTACCCGG +GAATGACTCTGTTCGATAATCATCCAGTGCAGCAGTATTCGGGCTTCAAT +CCCATCGATTTTCGCTTTGATGACTATGTGGAAGGAGCCAAAAGGTGCAA +AATTCGCCAAATTTCGCTAAAAAATCTGAAATTTCGCCGACTTTTCCCGT +AGCGCAGCAGTTTTTTCTTGATTTAGGCACATTTCAGGCAATTATTTTCG +GCAAATCAATATTTTTCCACCATATATGTTCTAGAATGTTTTAGATGTAC +TAGATTTTATTTTCAGACGAATCAAGTGATTTTCTATATTTTTACACTAT +TTTTTGTTGAAATATGACCAGAATATGCAACAAAGTGTTCCAGCTGCTGC +GAAAAGGAAAAATCGGCGAAATTTCGAATTTCAGTCTATTTTAATCTGTT +TAAGCAAAAAGAAAACTAATTTTTAAAATTCAGATTCGACAACCTTGCCA +ACCTGATTCGCTCGAGCACCCCCACGGATCCGTTCGCTAATTATCAAAAG +TATTTTTGAATTATTTTGAAAATCAATAAATTGGTTTTTTTTTCAGACCT +TGTGAATCCACAAGCACATCTCGTTCTCGTACGAATTCAGCAAAAGATCA +AAAGCATGGCCCGCCAACGTGGAAAATGGAGCTGCAGATTAAGAAAGATG +ACCACCACCACGCCGGCGGCGGAGCAGCAACCACAGGACAGAAGCTGTCC +CCACAACAGTTTTTGGCTCAGATAGCTCAGAGACAACAATCGGAGCAAAA +CGCGGATGAGGTGGCCAAGAAGAAGCGTCCGAACCTTTCGGTTATCAATC +CATCGCTTTTCTATGAGCAATACCCGAGAACATCGTCGCCAGTTGTTTAT +GCTTCAAAATCTAGTAATATTTTTTGGAGATTTTGGGAAAAAAACAAATT +TTCTCGAAAATACGCCCGAAATAGTGTTTCACGCGAAAATTGGCGATATT +TCAATTTTTCTGAAAAATTGCTATAATTTTTTCGATTTTCACGTGAAATT +GCAAGTTTTTGGATATTTTTCTCGAAAAACGTCAATTCATCGATTTACGC +AGCTAGTATACTCAGCAATTGACCATTTTTTTGCAGACAATTTGGTATTT +TTTACTTAAAATTCTTGATTTTCGACTTCTCGTGTGCTAATCACTTTTTC +AAATGCGCGCCCGAAGAATTTCTCATTGGAGCGTGCTTGCTTCGTGTAGA +TTTACGAGAGCTTTCCATTTATTTAACTTCTTTCGTGCTTTTTCAGTTTT +CCAGCGAGTTTCTGGCTCGACCCCTCGGTGTATTTTGTGCAAACACCGTC +ACGCGCAAATGCATGCACTTTTTCAACGCGCTGCGTGAAAATTCCTCTTG +CGATTTCAAATATTTTTTCCCGCCATTTTCCAAAATTTTCGAGAGGGGGG +GGGTCGAGCCAGAACACCTTGGTTTTCCAGCGAGCTTCCTTCATTTACGT +CGATTTTTTTTTTAATCTTCGTTAAAGTTCTAAAAAAAAACGACTTAAAT +CATTTTAAATTTTCCAAAATTCGGTTTTCCTTCTGCAAAAAAAATCAATT +TCCAGAACCATCCGGCCACTACGACGACAAAATCGCATCTCCACACGATC +CGGCAGTTCTCGCTTACAGTCGCCTTCGTGTACCTCAATCGGCCTTCGAC +AGTCTCTCACCAATCGACACCGACAATTGCTCATTCATCACAAAACACTT +GGGACCAACAACCGGTGTGAAGCGTGATTTGACGAACGACGAGTTGTCGG +ATATGATTGTATCAACTGGAAATCTCCGAATCAATCCAACCAACATCGAT +CATCATGACGAACCGGCACCATGGTCTCCGCTGAAACGTCTTCGCGCCGA +AAGTGGATCCCTATCAACTGCACAAGTCGCGTCGCCCGAGTTCTCACCGA +TCAAACCAAAGACAATGGAGTTCCACGAGACTGAGGATGATGTTTTTGAA +ACTGGACCACCACCAACCTACTTATCCGAAGGAAACGAAAACGCGGAGAA +GAAATGTGTTGAGCAGCCGAAAATCAACTACGACGACATTAATAATAGTC +GTCTTCCGTCGAATTCTCATTCGGCAGCACCGAATTCCGAGAAGAAGCAT +TTCGTTTTTCCGGTACGGGGGCTTTTTTTTGAATTACCGAAAAAATTCCC +AACTTTTTAAAGTTCAAAAAAGTCAAAATTTTTGTCCATTTTCTGGGCGT +GACTGCTTATGCCCCGCCCCCCTTTTTCGAAGTTTCTGCTTCTCGGAAAA +TGTATTCCCAAAGTGCCAGTTTTGAGGCCCCACGAAAAGGGAGCAGAACG +AAAGAGGCACCACGGATTCAAGATCTGGTGCGATTCCGGATCTGGCACCG +TGCCAACAACTTGAAAACGTGGTGCCTCTGAAAATTTGCTGCCAAGGTTG +AAATATCGAATGCATTACCCGTAAATCGACACGAGCTACAGTAACCTGTT +ATCCGCGTGGCGAGACCCATGCGCGTCAGATGTGGCGAAAATTATACTAA +AACCTGTTTAACTTGCAGAAAAACTTAATTTTTTTTGTTGAAAAAATTGA +GCCAAAAGACTCAAAAATTTCATAAAGCGAAACTTTAAAAAAATATATAA +TTTGTTAAAAATTTCACGAAATATTTATGAATTAATTAATTTTTCCAGGA +ATACCCAATGTGCCGTCACTCGTCAGTTCCATCGATTGCTCACTTGGTCG +GTGATCTGTCGGACTTTTGCCCACACGCTACAGCCGACGAGAAGATGCTG +CTCGACGAGGCGTCTTCAATCATCGAAAATACAACTCCAGCAGTGTCTAC +TGCTCCGGCTGCTGCTCCAGGAGCTACAATGCTCCAAATATAGGAGAAGA +TCACATATACAATAATATAATCTTATTGCATTTTCGCAATTCTCGTTCTC +TCCACACACATACACACATCATCCCAAGTATTCCTGTGCTGAATCTCAGT +TTGAATGATGTTTCATACCGTTTTTATCCCACTATTGCCTTATCGTTTCC +TGTTTTATTATATTTTTCATTTTTTATATTGCCACCACCACCACCAACAC +CACCCTCTCTATCTTTTTTTGTTCTTTTGCCTCCAGCAACATCATCACCT +AGTTTTCTGTGAATTTTGAATTTTGTGTTCCCCCGAGTCCCCTCTGATAG +GAATGATAGGAAAAACAATGAAAATGCGAGTTTTTTCAAAAAAAAAAATA +CAAACTAGGAAACTATAGAAACAAAAAAAAAACATTTGAGGCGCAGTACC +GAAATCTCTCCAAATTTGGCCCGAAAAATTCAAAAGAAAATATTTATTTT +TCTAAATTATTATTTTTCCGCCACTCCAGCCTCATTCTCATTGGAGCGCG +CAAAGTCATGTCGATTTACGAGATTAAGATTTTCAACGAGTTTCATCATT +GTTATCGATTTTCGTGTAAAGTTAACTAATTTTTTTGAAAATTTTCGCAA +AAAATTTTGGATAATAAAATGTTCAATTGGCACGAAAATGCAGATCTTCA +GCAAAAAAACCGACAGAAATGTGTAAAACTGAATCTCGTAAATCCACATG +GCATAACGCGCTCCAATGAGAATGTTTTTAGCGAAAAGTTTGAACAAAGG +AATATCAAATCAGGGCCAAATTTGGAGCAATTTCTAAAATATTTTCTCAA +TTCTTTCGGTATTCCACATTCAAACAATTATTCGGCCGTTCCCATGAGCC +TCTGAATCTCGATGGGATCCCTTGGCACTGCAGCAGTCAACAGCTCAATC +CCTCCAGCTTCACTAGTCGCCACGTCATCCTCGATACGGTATCCAATGCC +ACGAAACTCTTTGACAGGCCAATCCATCGGAACATACACTCCCGGCTCAA +TGGTAAATGGCACATTCGGTGGTAGATCAATGTCTCGGGATACTGTCGGA +CAATCGTGAACATCCATTCCGAGATAATGACTGACGTGGTGGGGACACAG +CTTCTCCGCCTGATGAATCATCTCCTTGTGATCCGTAGATCGAATCAGGC +CGAGTTCGGTGAAACTTGCCGCGAGAAGTTCGTTCATTCGGCGGAACAGG +GCGCTTAGGCGGACTTTTTCCATTGAGTGGGCGTAGGTGAGCAGTTCTTC +GTGAACGTAGAGAAGCGCTTCGTAGAGGGATAGTTGGGCGTCTGACCAGC +TGCAAAAACGAATTTTTTTTTGGGAAGGTTTTTTGAAACGATTTTTCAAA +TTTCGTTCGAATTATATTAAACTTTATATAAAACGATTATCCACGGATTT +CTGGCTTCCCTCATAAATTGGAATGGAAGAGTTTACCGAACTAGGCCATT +TTGGCTCGGCCATATCTGGTGCCGCGTCGCGGCTCGATTTTAGTTGTAAA +ACTAAATGCATTTGTACGTGTGGAGTACACGACTTTCCCACGCGTTGTCC +GGCGGGCGATTGTCAATGGAGCGCAAAAAATTCACTGAGGAAGGGGAGAA +CTCCGTGATTAGCACCGCCTATTTCTCTCACGAATCTATTTCTTCGAAAT +CTTCTATTTTTTAAAAATCAATTCCTGAATTCTGAAATTCATTATAGCGT +AATTTTTTGGGAATTTCACCCTGAATTCCATTTCTACGGAACAACATTTT +TTTCTCGAATTTGTGGTGACTCAAATTAGAATTTTCAAAATCTCCAGAAA +AAAAATCATTTTTCCTGAATTTTCTGGAGATTTTTAAAGGAATAAAGTGC +AAAAAAGACTCTTTTTGAGGCACCACCGAAAGGAGAAAGGAGAACACAAA +CCACGCCCATTTTTCCGTGCCGCGCGCAAGTTTTTCTGCAAATTTTTATT +TTCAAACGAGACAGCGAAACTCCGAAATAACGCATATCGTGTTCTTTATC +ATCAACGTGTTATTTCGGAGCTTCGTTGTCTCGTTTGAAAATAAAAATTT +GCAGAAAAACTTGCGCGCGGCACGGAAAAAATGGGCGTGGTTTCTGTTCT +CCTTTTTCACCTGTTCTCCTTTCGGTGGTGCCTCTTCTTTTTTTTTTCTA +TGTTTAGCGTAATTTTTTAGCCATCTTGGAATAGCCCCGCCCATTTCTCC +CACAAATCCATATCTACGAAATCTCGCATTCCAGAATGATTTGTGGTGTC +TCAAACGGGAATATTCAAAATTTCTAGAAAAACCCCATTTTTCTTGAATT +TTGGCCGAACTTCTGTAATTTCTGAAATTCTGAGAAAAATTTTCATTTGA +GTCACCACAAATACTGGAATGCAAGATTTCGTAGAAATAGACTTGTGGGC +GAAATCAGCAAAAAATGGGAAAACATTCAATTTTTTTTAATTTTTTGGGG +TTTTATCACTAATTTTTAGCACTTACAATCCAGAAATCGGAAAGCAACGT +GTCACATCTGACACATAACCATTCAAATCACACCCAGCATCCACGAGAAC +ACATTCCCGGGGATTTAGGTCATTATTTGCGTCCAAATAGTGAATAGTGT +TGGCACGAACACCACCGGCAATCACTGGTGGATATGCTTGCATTTCTGAT +CCACGACGACGTCCTTCAAACTCCAAGAGCCCGCAAATCGCGTTCTCGTT +GTGTAGATCACGTGATCCCGATATCATTGAGCTCATTGTCTGGGCTCCCA +CGTTGCACACGTCACGCATTGAGCTCATTTCGGATGGAGATTTTATTACT +CGGCGACGTTCGATCTGCAAGGAAAACTTGAAAATTGGCAAAAAAATAAT +TTTTTTTTTGAAATTTTAAAACGATTTTTCGGGTGTTCAGAAAAATTTTT +TTTAGGAAAAAATTGGAATTTTCCAAAAGTTTCAAAAAAATAATTTCTAG +AACTTTTTCCTAAAAAAAAAATGAATATTGAAAGCTTCGAAAACAGTAAA +AATTGGGAAAATTTTTTTACCGTTAAAAAATTTTTTTTTTTCGAAAAAAA +AATTTTCAGTTTAAAATTTGGAGCGTTTTCAATTTTATTGATAATTGGTG +AAACAAAATAAAAAGTAAATAAAAAATTTTTTTTTTGAAAAATTTGAAAA +ATTAGATTAAAAATGTTTATTCTGGGATGAAAAAAACCTCCTAAAACCAT +TTTCTGGAAAATTTAAACTTCCTATTTTGTTCAGACAATTCTTTTTTTTC +AAGAAAAAATCAAATTTTCCACTAGAAAATCGAAAAAAATTGACCTCGTT +TAAAAATTGGACAAAATTTGAATTTTTACTTTGAAATCCTCGAAAATCGG +ATTTTTTTTTCAAAGCTTGAACAATTTTCTGCAAATTCTATATATCTCTA +AACTCACAAAATGATTAATTTCCCGAACAGAATTAGCTTTAGCCTGTACA +AACTTATAGAGTAAATCATCAGAAGTCGAATCAAAAAACACTGCAGTTCC +CTTATCGCAAACTTTTTCCAAAGTCTGTAGAATCCGGCTAGTCGGCACAC +ATTCCGTGAATTTTGCAGTCTTTTCCCATTCGGATTCAGTTGGTAGGGCG +CCTTCCCATAGCTCATCATAGGCACTACGACGGTCAGCAAAAAGAATATT +TGTTTCTTTTGAAGATTCGGATATTCCTGATTGCATTATGTAATAACAAT +CTGGTGTGGTGATTCCGTTTAGGTATCTGCAAAAAAAAAAAATTTTTCAA +ATTTTTTTCTGTTAAAAATTTAATTTATTTTTTTTATCAAACAATTTTGA +ATTTTTCCCAAAAAAAATCCGAAAATTGTGAACAAATCTATTATTTTCGT +TGAACAAAAAAAAAACAAATTCAATTTTTAAATAATTTAATTTTCGTTCA +GAAAAAGAAATTTGTCGATTTTCGGCGGCAATGATTTTTTTTAACGAAAT +TTTCCTGAAAAATTCAATATTTCAATAATTCCTGATTTTCTAGTTTTTTT +TTTAAAGAAGAACATGTTAAATTTCTACTAATTTTATAACAAAAAATTTC +GGGAAAATCTAGAATTAAAAAAAAATGTTTTCAGAAAAATTCTACTAATA +TATTAATTTTAGCTTAAATTTCGATAATTTTAGGTTATTTTTCAATTTTT +TTAGGGCGAAATTTTGATTTTCAAAACAAAAATATTTTCTGACAAAAAAA +TTAATTTTCATTCTTTTTTAGATTTTTTGAAAAATTTTCAATTTTTTTCT +GAAGAATTTGGTACTTGTGTATTACATGCCCTCATTTTTAAATTAAATTA +AATGTTCATTAATTTCTCCATTTAAATTAAACGTGATATACATTTTCTCT +TTTTAGGCTTAGAAATTGCTATTTTGCTACTTAAAAAATTACTATTAAAA +TGAGGGCATGTAATACACAAGTACCAAGAATTTCAATCAATTCTTGTTTT +TGAAATTTTTTTTGGGAAAAATTCCAATTTTCGATTGTTTCTTCGATTTT +TTCAGAAAAAAAATTTTCTAAAATTTATTTATTTGTTTGAAAATTGGATC +TAAAAAAATTTCTCTAGTTTTTATTTTTTTTCTGGAAAAAGCTTTTTTTA +ACTTAAAAAGTTAATCTGTGGCCGAGTTTTCTCTCATCATTTTCACGGCC +ACGGCCATCAAAACCGAACCTGAAATGGCTTTTCTGTCGGAACGCGTGTG +GAACATCCGGTGCAATATATGATTTCCGTGCTCCTTTCATCACAACGACC +ACTTGCTTTTCTGAAACTTTGAGAGGTCATGGCCTAACTTTTAAATGGTT +TTCTAGGCCACCATGGTGATTTTATTACGGTACCGGGTCTCGACACGATG +AATTTTGTAGAATAAATTTTTCTGAAAAATTTCGTTTTTTTTTTTAGAAA +AATCAAATTTTCAAGAAAAATGGGAAAACATTTTTCAGGAAAAATTTAAT +TTTATAGAGAAAAATAGAATTTTTCCTTTAAAAAAATCTGAAAATTCGGA +TTTTTGAGAATTCTCTTTATTTGGATTTTAAAATCCAAATTTTCAAAAAA +AAATTTAAAAATCGGAAAATTCCAAATTTTTGAGAGTAAACTCGCCTTAA +TTTTTTTTTTCAATTAAAAAAATTAATTTTTTAAAAGAAAATTGGAATTT +TTACCCAAAAATTGGCAATTATTCGAGTTTTCAACGGAAAAATCTGAAAA +ATCCGAATTTTTGAAAAAAAAATCTTTAAAAATCCCAATATTCAATTAAA +AACCGCGAAATTTCGGATTTTTGAGAAAATTTTAATTTAAAAAAGTCCTA +TTTGTACTGCAAATCCTCATTTCCAAATGATGGCCTAACTTTTTCAGAAT +TCTAGGCCACCAGGCCATTTCTCTGCCTCTTACCCCCAGTTTTGACCTCT +TTTTTGAGTAAATTCATCAAATTCGTCCTTCTCATCGCATATTCCTCATT +TGGAATTCGCGATGGCCACATTGGTAGGCTCCGCCCACTTCTGAGCATTT +TTTTTTTGGATCTGATCTGTGTGGGAGGGAAATTCGAATTTTTTTAGAAA +TGAATAAAACTGAAAAAAATAGATTTTTTGGGAAACAGGGAACCTGAATT +TTCGAGAGAAAAAAGGAGGTAAAACAAAAAATTCGATTTTATATTGAGCA +AAAATTAATAGAAAAAATAAACTTAACAATTATGAACAGAAAAACCTACT +AAAAAAGTCTAAAAAATGAATGAAAAATTGCAAAAAAAATCTACAATCGA +TACGAGACTCCTCCTCCAACAATGCAGTTCTCGCCGGTGATGTACCTGAA +AAAAAGTGATTTTTTTTTGAATTTTTAGAAAACAAAATTATGAAAAAAAC +CAAAAAATTTCCGAATAATCGAAATTTTTCGGAAGTTTTAGGTTAAAAAA +ATTTTTTTTTGATGAAAAGTTTTTTTTCAACAATTCTGAAAACTAAAAGT +ACCAAAAAATTTTAGTTTTTTCGATTGTTTCAATATGATAATTTTTTTTA +AATGTTTAAAATTGTATTTTTTCAAAAAATATTATCAATTTTCCAATTTT +ATGGTAATTTTGGATGTGAGATTTTTTTCTTCAAATTTTCGAAACGTTTC +TCGATAAAAAAATTTTTCAACTGAAAAACTACAAAAAATCCTCTTATTTT +GAAGAAAAATCGATATTTTCTCAAATTGTTCAGATTTTTTCTGTTTTTAC +CAAAAGTGACCAAATTTTGAGACTTTTCGATCCAATGTTTAAAATTTTTT +TCCCGTTTTTTCGATATTTGCGGTTTAAATTTTTTTTAAATTTTTTGATT +CAATTTTAATAAGTTTGAGTGTTTTTCGATTTTTTGTCCAAATTTTTTCA +AATTTTTTTCCAGAAAATTGGTAGAAGCCAAAAAGTGCGATTTTTTTCCT +TAAAAAAGATAATTATTCAGTTTTTCGACTGTTTTCTTCTTGCTTCCAGA +TTTTTTCTCGAATTTTTTTTATATTTGAATTGTATTTTTAAATATTATAC +TCCTAATCGATAAAAATTAGTTTTTTTTTCAATTTAAATTGGAAAAGAAC +GTTCTTTTTCGTAAATTTTAGTGATTTTTGATTCCAAATTTTTGGATTTT +TTCAAAAAATTTCCCAGAAAATTTTACCTGGCTTTGGTAGAAGCCAGAAA +TTCGATTAAATAAGCTTTTTTGGGTTTTTCGACAATTTGTCAAGTTAGGA +ATTAAACTTTTAAAATTTTTTTCAAAAATTTTAAAAAACTAAAAGTATTT +CTGAGAATTTTTCTGAAATTAATTATTCAGTTTTTCGACTGATTTCTGCT +TGCTTCCAGATTTTTTCTCGAAGTTTTTATATTTGATTTTTTTAAAAAAT +ACTCTTAATCGAAAAAAATTCATTTTTTGAATTTTTTCGGGACTTTTTTT +TTCGAAATTTTCGTAAGTGTTAGTGTTTTTCGATTTTTGATTCTAAATTA +TTGGATTTCTTCAAAAAATTTTTTCAGAAAATTCTACCTGGCTCTGGTAG +AAGCCAGAAATTCGATTGAAGAAGCTTTTTTTTCGGTTTTTTGGACAATT +TTCCAAGTTTTAGTTAGGAGTTAAACTTTTTCAAATTTTTTTTGAATTTT +TTTCAAAAACTTTAAAAACTAAAAGTATTTCTGAGAATTTTTGAGAAAAG +CATTTTTTTTCTCGAATATTTGAACTTTTTAAATTTTTAAAGCTTTTTAT +TTTTAAATATCAATTCGAATATTTTACTCTTAATCAATGAAAAATCGATT +TTTTTGATAATTTTTTTCAAAAAAAAATTCGAATTTGAAATTTTTTTCAT +TCAGAAAAGGGAATTTGACTATTTGAAAACAATTTTTTGTTGAATTTTTC +GTAAATTTGAGTGATTTTCGATTTTTGATTCCAAATTTTTGGATTTTTTT +TTGACAATTTTCCAAGTTTTGGTTAGGAGTTAGATTTCTTGGAATTTTTT +TTTGAATTTTTTTCAAAAATTTTAAAAACTAAAAGAATTTCTGAGATTTT +TTCCTTAAAAAAGAGGAATTTTTTAGTTTTTCGACAGATTTCTGCTTGCT +TCCAGATTTTTTCTCCAAGTTTTTATATTTAAATCTTTAAAATTTATATT +TTTAAATAATATTTCAGATATTATACTCCTAATCGATAAAAATTCGTTTT +TTTTTCAAATTTTAATTGAAAAAAATCGATTTTTTCGATAATTTTTTAAT +TTTTTTAAAATTCGAATTTGAAACTTTTTCATTCAGAAAAGAGAATTTGA +TTATTTGAAAACAATTTTTAATTTAATTTTTTAATCCTTTAAATTTTCGT +AAATTTGAGTGTTTTTTGATTTTTGATTCCAAATTTTTGGATTTTTTTCC +AAATTCTCCAAATTCTTATTTTTGCAGAAAATTCTACCTGGCTTTGGTAG +AAGCCAAAAATTCGATTTAAGAAGCTTTTTTTTGGTTTTTTTTGACAATT +TTCCAAGTTTTAGTTAGGAGTTAAACTTTTTTCAATTTTTTTTTTTGACT +TTAAAAAAAAATTTAAAAACTAAAAGTATTTCTTAGTTTTTTCCTTAAAA +AAGAGGAATTTTTTAGTTTTTCGACTGACTTCGTTTTTGAATTTTTAAAA +ATTCAAAAATTGTATTTTTTAAAATTCTAATCGATAAAAATTCGTATTTC +GATTTTTGATTTCAAATTTTTGGATTTTTTTCAAACATTTTTCCAGAAAT +TTTTACCTGGCTCTGCTAGAAGCCGAAAAGTGAGATTTTTTTCCAAAAAA +AGATAATTATTTAGTTTTTTTTCTCGAACGTTTTATTATTTGAACTTTAA +AATTGTATTTTTAAATAATATTAAAAATTTAAATAATAATATAGAATTTT +TTTGAAAATTCCTGAATTTTCTGATTAAAAAAACATTTTCTGATGCATTT +TAGAAACTGAAATTTTTTGAAATCTTTTTGGAATTTTGGAAAATTTCGAA +TTTGTTGATTATACTCTTAATCGATAAAAATTCGTTTTTTTCCAATTTTA +TTTGAAAAAAATGATTTTTTCGATAATTTTTTTGATTTATTTTCGGGAAT +TGACTATTTGAAAACAAAAACTTTAAAAAAAAATCAAACTTTTTTTTTGA +AATTTTCGTATTTAAATTTGAGTGTTTTTCGATTTTTGATTCTAAATTTT +TGGATTTTTTCCAAATTCTCCAAATTCTTATTTTCAGAAAATTCTACCTA +GCTCTGGTAGAAGCCAAACATTCGATTTAAGAATCTTTTTTTTTTTTTGG +ATTTTTTTTTGACAATTTTCCAAGTTTTGGTTAGGAGTTAGATTTCTTGG +AATTTTTTTTTGAATTTTTTTCAAAAATTTTAAAAACTAAAAGAATTTCT +GAGATTTTTTCCTTAAAAAAGAGGAATTTTTTAGTTTTTCGACAGATTTC +TGCTTGCTTCCAGATTTTTTCTCCAAGTTTTTATATTTAAATCTTTAAAA +TTTATATTTTTAAATAATATTTCAGATATTATACTCCTAATCGATAAAAA +TTCGTTTTTTTTTTCAAATTTTAATTGAAAAAAATCGATTTTTTCGATAA +TTTTTGAATTTTTTTTTTACAAATTCGAATTTGAAATTTTTTTCATTCAG +AAAAGAGAATTTGATTATTTGAAAACAATTTTTAATTTAATTTTTTAATC +CTTTAAATTTTCGTAAATTTGAGTGTTTTTTGATTTTTGATTCCAAATTT +TTGGATTTTTTTCCAAATTCTCCAAATTCTTATTTTGCAGAAAATTCTAC +CTGGCTTTGGTAGAAGCCAAAAATTCGACATAAGAAGCAACATCAGACGG +TCTTCCAAGTCTTCCCAACGGAATCATCGATTCCAAGTGTTGTTTAATCT +GACGAGCTTCTTCTCCAGAAGCATGATCCCATACAGCACCAGTTCCGTCT +CCTTCAATCATTCCAGACACCACACTATTCACGCGGACTCCTTGTTTCGC +GGCACTCTGAGCTACGGATTTTGTAAGTGATAGGACACTGCTAGATGCAA +CTGAGTAGAGACCCATATCGATTGATGGAGTGAAGCCGAAACATGACGTT +AGGTAGATGATACTGCCGTTTCTGGAAAAAATCGATTTTTTTTGGACGGG +AAATTTTGCCTGCCTACGTGCCTACCTGCCGGCCTATTTTAGCCTATTTT +TCATTTTTTTTTTGTTGTTCTATTTTTTTGCCGTTTTTTGGGAATTTCAT +GATTTCTAGGGTAGGCACGACTTCATGCCTACGTGCCTATCTACCGGCCT +AACATTTGATATTTTTTTAGAATTCCATGATTTCTAGGTAGGCAGGTAGG +CACGAATACATGCCTGCCTACCGCCTGTTTTTTTGAAATTTTTTTGTGTG +AAAAATTAAAATTCATGGGAATGCTTTTTTTTTCAAAATTCAATGATTTT +TAATGCAGACCGCGCCTATCTGCCTACCGCCTATTTTTGGCATTTTTTGT +GTGCAAAACAAAATCAAATTAGCTTTTTTCTTTTCGTTTTTCTACGATTT +TTTCCAAATTTCAAGATTTTTCGGATAGGCACGACTTCCCACCTACTGTG +CCTACCTACCTACCGCCTATTTTCGGCATTTTTTGTGAGCAAAAAGAGAT +CAAATTAGCTTTTTCTCCTGTTTTCTACGATTTTTTTGGGTAGGCACGAC +TCCATGCCTACCGTACCTACCTACCTACCTCCTATTTTCGGCATTTTTTC +TCGTGCAAAAAATCATATTTATGAAAACACTATTATTTTTGTTTTCTGAA +TTTTTTTTCCAAATTTTGTGATTTCTAGGGTAGGCACCGACTTCATGCCT +ACGTGCCTACCTACCTACCGCCTATTCTCGGCATTTTTGTGAGCAAAAAA +TTAACATTCTTGAAAATCCTTTTTTTGTTTTACTACAATTTTTTCAAGTT +GCATGATCTCTAGGGTAGGCACGATTTCATGCCTACTTGCCTATCTACCT +ATTTTTCCCTTTTTTCGTGGTTTAGGTAGGCAGGCATGAGTCAGGCACGA +AAATCTAGAAACATAATTTTGATTCTATCGGTAAAATAGGCTTTCAAGAC +AGTTTGAATTTTTCGAATTTCTACCAGCAAAAAATAATATCTGAAATTTT +CGCGGCGAGACCCAAAAACTGACTGAGATTTGGCGAGCGTCGACATAGCG +GCTTGCGAAAGACGGAACGGTGTTGTCAGATTGTTGGCGAAAAGCTGAAA +TTGGTTTTTCGAGGTCAATTTTCCACGTGGAATTCAAATTTCAGCACTCT +CGAACCTTATCAAAATCCTCGCCGGATGTCTCAATAATCTCGCCGAGCAC +CTCATTCTGTGGTGGAACTATAATTAAAGTGTCCAGACCGCCGAGCTTCT +CAGCCACTTTCGTGATCAGCTCCTTCCTGTGCTCGGCATTTGCCACGTCT +AATGAGAAAGCTGTGACGTCACCTCCAACCTGAATTTATTCCCGAATTTC +TCTTTGTCAAGTTCTGAAAATCTGCCTAAACCTTTATATTGTCCTCTGCA +ACCTTTCCCACACTATTCGGACAGTCTGCGGCGGCGGCGACCTTGTAGCC +GGTGAACGCGAGTCTTCTCACGACGGCTTTACCCAGTGTGGACGTTGCCC +CGATTACAAGTGCACATGACATTACGCTGAAAGCCCGATGAGGAGGCATA +TTTATAGATACACCTAGACATCAGGTACATTTATTTGGAAATCCGTAGAA +AATAAAGAACATGTGAAAATAAAACAGATCATTTTATTATTTAGAGGGGA +GAGGGAGGGGGAGCAAAGTCGCTGACTGAGAACTTTCGAAAACCGGTTAG +TTACTCCAGTTGTACGGCTTATTCATGCCATATTTTCCAAGATTTCCACC +ATTGTGTTGGTATTGAGAATGTTGATTCTGCTGAGCTGCCGGCTTCGATC +CAGACATCTTGTCGTAACTCTTGCGCTCGTCATCCTGTCCGTAGAGTTGA +CGACCTCCAGCGCTGCTTCCAACATTGGGCATCATGTTCATGAATGGAGT +AAACTGGTGTGGAGCAGGTGAGTACTGCTGCATGAACAACGACGACAAGT +TTGGCTGCTGCATGTAGTTCGTCGCCTGGAACCCTGGTGGTGGTCCAACA +TTCGACGCCTGCTGTGGCTGCTGATCCCGAGAGCTTTGAGATCCGAACTT +ATTGAAGTCCATAAGTCCATGAGTCTCTCGTTGTTGACCAGATTGCACTT +GTTGCGCAGAAGCAGCCTGTGACAGAGGAGCAGTTGGAAGCAAGCTTGTA +AGATCAACTCCCATTCCGTATTGCATAAGAGCAGCAGTATATTGCTCATC +TCGAACTCCTGGCATTGGATTGTACATGTTCATGTAGTTGTTCATGTATG +GTGCATATGGGAGTTGTTGAGTGAACATCATATGTGGATGCTGTTGTGGA +TGTCCAGTCGGTTGTGATTGAGCTGGTGGAGTTTGTTGCTGCTGCTGCAC +TGGCTGTTGTGGGGCTTGTTGCTGCTGCTGCTGTGGCTGGTGCTGCTGAG +CAGATTGCTGTGTTGGAAGTGGTCCAGAATTGTTGAACTTGTTCGGCGCC +ATCCTGTCCGTTGGTTGATATGAAGCGGACGAAGTGTCATAGGACAATCC +TCTGTTAGATTGACCATATGACAATGGAGGTGAAGTCGATTTTAAGTTGT +AATCGCCGTTAGGAATTGACGTCCTTTCTGGCTGAAAAATAATCGAGAAT +TAGAATAAATCGTCTTTGCAACAAATTTAACTCACCTCAACTTGTTTCGG +CATAATACGAGAAGAGTTAAATATATTTTCACTGGCATTTGAGATCGAGG +CAGCGGAGGATTCAGTAGAAGGAAGCTGTGGGCTTGGAGCAGCCTCAACA +AATCCAAATGAGTAGTCATGAATGTTCGTTGGTGCAGTTGTGCCAACAAA +TTCCACTCCAGGATCAGGAATAATCTGGACTGGTGCTGCACTTGGAATTG +GAGATAATCCTAGTCCTGGTGCTTCACTCAATCCTATTCCAAGATCCGTC +TTCAGTTGAGTGGTCCATGCTTGATTTGGTTCTGGGGTGCTTTGTACATT +TTCATCGTGATGAGTCGACACATTAGGCGTCTGCTCCTCAGCCAAAACTG +ATGATTCACTGAAAATTAAATTTTTAATAATCTAAATACAGGGACAGAAC +AACTTACTTTTGGAAGAAACCATCTTCTTTCTCCGGCTGATGCGAAGTTT +CTGGCTCGAAAAATACTGGCGCTGCTGCTGGCTCTTCTTTAACTGGTGCA +ACTGACGGAAGTGGAGGTTGTGGGGAGAGACTCCTCCTTGGCGGAGCTGC +TGGTTGAGGATTCTGTGCCTGGTGCTTTCGGAGTGCTTCTTTGCGATGGG +CAGCTGCTGCTACTGCAGCAAATGAGATCGGTGCCGGCGCAGAAGATGTG +GGAACAGTGGCGGTGACGGATTCCTCTACTGGTGGTTGAACTTCGGTGAC +TGTGGTATCCACTTTAGTCTGATTCTGAAAAAAAAACACGTTTCGTCATT +TTCCTTCTTCAAAAAATTCTTACCTCATCAAGATCAGCAGTGAACGCATC +TGGCTCAAGTGCTGATGATGGAGCAACAGCTCGAGAATATCCACCTCTGG +CGCCACCTCTTCCACCTCGTCCAACATACGGTTTTTCAAATCCTCCTCGA +GTCGAGCGTGGTGCTGCTCCTTCCTTATTATCACGGTTATCCCGATTATT +ATCTCGGCTTTCTCTTGGAGCTCCATTGGATCGCCCGCGGCCTCCTCGAT +CGACGAAACCGGTGCCTCCACCTGAAAAAAACATATCAATATTTGATCTA +TTTCAATCAAGCACGAACCTCTGCCTCTTGCTACAAATCCTCTGTTGTTA +TAACTGCCCTCTTCCGGCTTCTTCTTTTCCTTTTTGGCTCCTTTCTGTTC +AGTCCACGAGTCAAGTTTATCTCCAGCATCCAGAATGTGATCGATTGCGC +CGTAAAGATTGTTGTCAGTATCCAATAGCGCTATCTCAGCTTGTGCTTGT +GTACATCCGGTGGTTTCGATAATCTGAAAATGAAAAAGACATGAGCAGTG +AAAAAACCCCTCTTGGGAATGCGCGAACACTTTAATTAGCCCAAATGAGT +AGGACATCTGGGTACTCTTACTCTCGCTGCACCATCTCAAGCGCGGACAC +CTGCTTTTGTCCTTTTATTTGCCATCTGGCCCCGTCTTATCGATTCGAAA +TTCCTATTGACACTGAAAGCGGACACTAGAGAAGTTCAAAACAACAAAGT +CACGTGCGTCATCATGTCGGTGTGTGGCGAGCGTTCGCGTGATGCAAAGA +TCACTATTTTCAGGAAAGCGTCATTTCCAGCTTGGAGACTTACCGTCTTG +ATCATAAACTGTATGTCCTCCTCATTTCCGGAATTTCCTTCCAGTGTGAG +TCGTGCAAGTCGCGCTTGATCGCTGGTAGCTTTTTTGTCGCCTTTAATAC +CCATTCTGAAAACAAATTATAAATAAAAAGGGTCAGTCATGTGAACGCAA +GAATGGAATGAGAATCACGAGAATACAACTATCAAAGGAAGGTTGAATGA +AAGGAAGGTCAAATAGATGACAAAAGTAGGAAAAGAACGAAATATGGAAC +CTTCCAGATCAAAAAAACATTATCAAAAGAAAAGCCTCGCACAGAAGACT +CTAACGAACATGTTAGGATGAAGAAATATTTCAGCAATACATCACGTTGA +ACTTTGGAGGATATTCTAGAGAAGAAAACCCCTACATTTTACAATAATTT +TGAAATGGAATTCGAATGAACTGCTATACAATGGAGAATCCTATTTAGCG +ATGATAAAGTGTAGGCTTGTTACTAGATTGAATAAAAATTTCGAAATGTA +ACAATACATTGACTGAAAATTTGGGTATTTCAGAGTGTGATATCACAAAA +ATCAATATTTCCACTAAACTCAAAAGTTCTTACGCTGAAAAATCATTAAA +AAATTGAAAAATCACCGCAAGCTAGACTAGAATCGCGTTCAAATCTCGCA +AATTCCCGCAGTTGAAAATGCGGGCGACCGCGACGCGAGCCGCAACGCAC +CCCTCCAAACATGCGGCATGGGTCTCGCCACGACCGAAAGTACGGTCACT +CTTGGCAGTATAAAAGGCGACCATTTTCCGCTATTTTCCGGTAAATTTTC +AAATGAAACTGTGTTGCGGAGGGGGTTTTCCGCTAATTTTGCGGAAATTT +AGCTATTTAATGTGAAAATGTGAATAAAACAAAAGAAAGTGGGGAGGAAT +AGCAAGGAAACACACTGTTGAACCCTGGGAATTATCGATTTTGTATGAAC +TCTTCTTTTATGGCGTCGAAATTATCGACACGAAAACTCAAAACCTTGTC +ACATTTCTGAGAGAGAAATATCATTTTCAGCACACATGAGTCTTCCCAGA +TTTCGACTCGTTCAGGGAAAGGCGATCGGCGAGCGATCAACGCCAGGAGT +CAGCACACCAGAGCCGGTAATTGTTTTTTTTTATTTCAAAATTTCTACAA +CAACAAAAAGAACTAACAATAATTTATTCCTTTGATTCCAGGCCCCTCCG +CAAATAAAGCAGGAAGTCGACTACCAAGATGCTCATCAAATGGCTCCGGA +ACCCGTGGAAGCACCCCGTAAATATTTAAAAATTTAAAAAAGTTAGAAAA +AAAATTTGAATCCCAATTTTCAGAGGCTCAAAACCATCAAATGCAGCCGC +CTCGTCAACCTATACAACAGCAGATGCAGCATTTTCAGTCACCATCGCCA +ATGGCTCCACAAGGGCCGCCCGGGACTCCACAAAACTCTGCAGCGGCGGC +CGCCGCTGCTTCAGATGACAAAAACGTGACAAAATGCGTCCGCTTTCTGA +AAACTTTAATTAATCTGTCGAATAACGATGATCCAGAAATGCCGGACAAG +GCCGCCCGTGTCAAAGAGCTAATTCGAGTGAGGAATTGAGCGAAAAACGC +GATAAAAACCGGACAAATTCGGATATTTCAGGGCGTAATTTATCTGGAAA +CGACGGCTGAAGAGTTTACACGAAATCTGCAACAAGTGCTCAAATCTCAG +GCTCAACCGCATCTTTTACCATTCCTTCAGAATACTCTTCCGGCATTGAG +GAATGCTGTTCGAAATGGTTCGGTTTTATGTGCAAAAAAATTAAAATCGA +CAAAAAAAAAATCATCGAAAAACAGGAAAATTTGAGTTGAAAAGCAGCGA +AAAACTTGAATTTAACATAAAAAATTGCAAAAAATCCGTTGAATTACATT +TTTCAAGAAATTGTGTAGAAATTCCATGAAAAAAATTCAAAATTTCCAAA +TTTTTTGGCTATTTCTAGTCAATTTCTTTAAAATTCCATTTTTGATAGCG +AAAATTATCAAGTTTCTAACAATTTCAAGCTGTTTTTGGTGATTTTTTCA +ATTTTTCGGCTTTGAAATTCCATTTTCCGGAGTATATTGTCATAATATAT +CCGAGTTCCACAAAATTGAGCAAAAAAAATTAAAAATTTCCCTTTATTTA +AAAATATTTTCAGCTGTCAGTAATATATGGATTTTCCGCAATTTTTCTCA +CAATTTTGAGCAAATTCCTGATTTTCAGCCAATTTATAAGGATTTTCACC +CATTTTCATAATTTAGGGCTATTTTCAGCTGAAAAATTGTAATTTAAAGT +TTTTAAAATTTTTATAGATTTTCTCAAATTTCAGCTCAAAAATTCGATTT +TCAAGCGCATTTCCAGGCAATTTATTAAGATTTTCACCAATTTTTTTAGC +TTAAAATTTAAAATTTCCACATTTTTTGTCTATTTCCAGTAAATTTCTTT +AAAATTCTATTTTTGAAAGCAAAAATTATCAAGTTTATCGCACTTTTTCA +ATTTTTCCGGAGTATATTTTGGTAATTTATCCGAGTTCCACGAAATTGAG +CAAAACAATTATTTAAAAACTTCCCTTTATTTAGAGCTATTTCCGCAAAT +TTTCTCGCAATTTTCACGCAATTTTCATAATTCAGGGCTATTTTCAGCTG +AAAAATTGCAATTTAAAGTTTTTAAAATGTTTATAGATTTTCTCAACATT +CAGCTCAAAAATTCGATTTTGAGGCGCATTTCCAGGCAATTTATGAGGAT +TTTTACCTATTTTCTAGATTAAAAATCTTTTTTTTTCCTCAATTTTGGAC +TATTTTCCCTAATTTTCAAATTTCCAGGCACTGCATCAGTTGAAGGCGTA +AATCCACCGCCTGGCTACGTTTTCAACAATGGAAGAACCCCAGGACCCCC +TCAGCCACCTCCACCTCAACAACAATCCCAGCAGCAGCCACCACTAGAAA +TGCGTCAAATTCCGAATCCGAATCAAATACCCCCACAAATGGTTCAAGGG +GGTCCCCATATGGTATCTGTAGGCGCCCGGCCAATGATCAGGCCTATGGG +CCCCGGCGGCCCAAGCCCAATGGGCCTACAAGGCCCCGTACGAGGGCCGA +TGGGACATCAGATGGTCCAGATGCATCCTCCTCCCCCACCACAGCAGATT +CAACAGCAGCACCCGGCTCCCCCTGTAGAAATGGAGGTGGAAGAGAATTT +ACAGCCTACCGCGGCGGCCACGGCCACGAGGCAATATCCTGAAGGATCGC +TGAAATCGTCGATTCTGAAGCCGGATGAGGTGCTGAATAGGATCACGAAA +CGAATGATGTCATCGTGTTCGGTGGAAGAGGAGGCGCTTGTCGCGATTTC +AGATGCTGTTGAGTCGCATTTAAGGGAACTTATTACACTGATGGCCGGAG +TTGCAGAACATCGGGTGGAGAGTTTGAGGTATTGAGGAGAATTGATTTTG +CTTCAAAATACGGCAGCGAAAAAAAAATTAAGCAAAAATAAGGAAATTAT +TGAAGAAAAATCGTCTTAAAAACAATTTTACATTAAAAAAAAAGATTTTT +AAATTTCAAAGGTTCCGAACTATTTATTAAAAAAACATCTAGATTTTGTT +TTAAAATCCAAACAAAAAACATTGCTGAAACGCGGTAATTTTTTTTCAAA +AAAATATAAAAATCTGAGAAATATTTTCAAAAATATCTCCAATTTTCCCC +TGATTCCGAATATCTATTCGAAAAAATTCAAAAAAAAAATTTCCCTTTAT +ATTTCAGCTTGAAATCGCTTTGTGCATGCACACCATGAGATTTTTCAAAT +GCGCGCCCAGATAAATTCTCATTGGGGCGCACTTGCTTCGTGTCGATTTA +CGGGAGCTCTTCATTTTTAAATTTCTTTTAAGCTTTTTTTTTCAGTTTTT +CAACGAGTTTCCTTGATCTTCGTCGATTTTTTGTCATTTTTTTTCCTGAA +ATTTTGTTTTGTGTCAATTTGAAAATTTTTTAGGTCAAAACTCCTGTGTT +CGTCGAGATCTGACGTAAAAATATAAAATTCCGGGAGTTTTGAGATATAA +AAAAAATATTTTAAAAATTTCAGAAAAAAAACTGACAAAAAAGCGACAAA +ATAAAAGAAACGCGCAAAAAAAAAAAAAAAAAACTTAAAAAAGCACGAAT +AAATTTTTTTAAAAAATGGAGAGCTGCCGTAAATCGACACGAAGCAAGCA +TAAAAAAATGGCTTTTTTCCTAACAATTTTTTGTGAAAAATCCGAATTTT +CCATCCTAAACACTACAAAAGATTCCAGAATTCCGGAGAACTACGTGGCA +ATTGATGACGTCAAACGGCAACTTCGATTCCTTGAAGATTTGGATCGTCA +AGAGGAAGAATTAAGGGAAAGTCGAGAAAAAGAGTCGCTAATTCGAATGA +GCAAGAATAAGAATAGTGGAAAAGAGACGATTGAAAAAGCGAAAGAAATG +CAACGACAAGATGCTGAAGCGAAAAGGAATCGAGATGCGAATGCGGCTGC +AATTGCAGCACTTTCCAGTAATAAAACTGTCAAGAATAAGTTCGTTTTTA +GCGTGAAATTTGCAGAAAAATTATTTTTAAAAAATAGATTTAAAAAAAAC +AATTTCCTGACCAAGGGTGTCATTTTTCGATTTTTCGGTTTTCAAAAATT +CGAAAAATGAAAGTTTCGTTTTTCGATTAAAAAACTGAAAAACCGACACC +TTTGTTTCTGAGATTTGGATTTAGAAATAAGCAAAAAAAAATTATTCAGA +AAAAATTGTTTTACAATGCTGCAAAATCGATGAAAAAATAAAATAAATCA +ATAACTAATTTCTAAAAAATGGAAAAAAATTTCGTTTTTTTCGAATTTGT +ATTTCACAAAAAAAAATTTTTAGAATAAAAATTTTCAATTAAAAAATTAC +TATTTAAAATCACTGAAAAAAAATGAAAAAAATAGAAAATTCAGAAAAAT +AGCGAAAAAAAAGTTTTTTTCCAGAAATTTCGTTAAAACGATCAAGATTT +TAACCCTAAAATTTAGATAAAATCAATTTCTTGTGGTTCTTAATTTAAAA +AAAAAAACAGTACTTTCCAGTAATAAAACTTTCAAGAATAAATTCGTTTT +TAGTGCGAAATTCGCAAAAAAAATTACGAAAAAGTGAAAATAGAAGCTGA +AAGGAAAAATGTTTAAAAAATAAGAATATTTTCGACATTAATTGGTTTTT +ATATATATTTTTTTGTAGAAGTTTAAAAAAATTACTAAAATCACTGAAAA +AATTGAAAAAAATTTTAAAATCTGGAAAAAAAGCAACAAAAAATTAATTT +TTCCAGAAATTTCGTTGAACTATTCGGTATTTTAAGCCTAAAATCAAGAT +ACAATCAATTTGAACAAAATTTGCTTTAAAAATACTAAAAATTCGAAAGA +AATAGAAAAAAAAAGAAATTTTCGAAATTTGGATTTATTGTTAGAGAAAA +GCTGAACACTTACAAAAAATTAATTTTTTACGTTTTGAGAAAAATTTTTG +AAAAAAAAAATCGATTTTTAAATAATTTTTAGAATTTTTTAGAACTATAA +TTTTTGAATTTCAGTGACTTATAATCACAGAAAAAAATGAACGAAAAACA +AATGAACATCTTTTCGGCAAAAAAACGTATTTTAAAAAAAAATTTAAATT +TCTAGTGACTTTGAAAAAAAAACCACATTTTCCAATAATTTCCAGGAATA +AACTAAATTTCTTTGGAGAAATTTGAAATTTATTTCACATTTCGAAAAAA +TTTATATAGAAATAAAAATTTATATGAAAATAAAAAATTTGCAGCTCCTT +CCAGTAATGAAACTGTCATTTGTTGAAAATTAGTTTTTTTTTAATTTAGA +AATTCTCTTTTCGAAAAAAAAGGTTTTTTTAAAACTTGATTAAAAATTAA +TTCATTTTTTTCCAAAATTAGGGAAAAAATAATTTCTAAAAAATTAGACA +AATACACTTTTTTGTTGAAAAAAACAACATTTTCCAATAATTTTCTTTTT +TTTTAAATTGCTTCCACTAAATTCACTTTTTGAAGAAATTTTTTGAAATT +TTTACTGAAAATTGTTGGAAAATTATTAAATGTGCATTTTTTTGCAATTT +CCAGTTGATAAACTAATTTCGGTTCAATTTAAAATAAATTTCGAAAACCA +ATTTCAAAAAATTCATTTTTTACAATTTGTTTTTGTTGATAAAACGAGCT +AGTTTCTACCAAAATACCGCTTTTTTACATTGAAAATTTAAATTTCAGAT +GGGAAAACACGGGCGCCGCAACGACAGCACCTCGTCCACGAACAGTACGT +GTAACAACTCGTGATCTACATCTTTTAGTCAATCAGGATAGCCGATTCAC +AGGGTAGCGATTTTTTTTGTTTAAAAAATTTTTTTAAAAAACACCGTATT +AAACATTGATTTTTATTGGAAAAAACTGATTTAAAAATTTTTCAAAAAAC +TTTCAAACGAATGGTAGTTTTTAATATTTTAATTTTAAAAAATTCCAATA +AAAATCAATTTTTATACGATTTAAAAAAATTTTGAAAAGTTATCCAATTT +TCTCCTAAAAAAACTCATTTTTTTTCCAGAACATTCATCCGTGAAAAGAT +GTCATACGGTGGTCCGGCAGTCGATACAACTATCTGAACTAAAGAAATCT +CATGGAAAAAGGAGCGAAAATTCTGCTTTTCTCGTTTTCTTTTTTTAAAT +TTAATTTTATTTTTCCACAAATTAAAACAATCACTTTTTTCCAGTCAAAT +AATAATTATTTCTCATTTTTAAACGAAATGCTAGACATAAAAAAAAGCTT +CTTTTTCAGCTTTTCAGCCAAAAATTTCAGATTTTTCAGAAAAAATTCAA +CAACAAAAAATTGGCAAAGTGCAAAAAAACCAGAATTAGATATTAAAAAT +ACAGGAAAAATCGAGAAAAATGAGTTACAATTCAGAAAATTAGGCAATTT +TTTTTTCAAAATTTCTCAAAAACACTGAAATTTCGGTATTTTTTTCTCTA +CTTGAGCACAACCTCGTGTTGCACCAATCGAACATAGTCTTTGAGCGTCG +GTGGAAGTGGAAGCTCATCGATTATTCGCTGATAGACACCGTCGGCACCG +GCGATTTCCAGATTTCTACGTTGGCGAAGGTGGATGGCGCGCTGGAAAAA +TTTCTAATTTCGAGCTGAAAACTCTTTTATGAAAGCAAAATTTCATAGTT +TCAATTCAAAGTTCGAATTCCTCGCAAAATTTCAGTCGGAAAACCGAAAA +CTAGAAGTTTCTTGCTCGAATTTGAAATTTCGAGGGGTACGGTATCCTCG +AAAGTACGCAAACACCGAATTTTGTTTTTTTGAAGTTTTGGCGCCAAAAA +TACAATACCCGGGGTCTCGACACGACAAATTTTTAAAATTTTTTTGAGTA +CTGTAATTTCAAACAAAAAGTTTTTTTTCGAATAAACTCGAATAATACGA +TAAAAAACATATTTTAATAAAAACCGTGGCAACGAAAGTTTGAAAGTACA +GTACTCTCTTCAAAGGCGCACACCTTTTACGCATTTAACTTTCGTGGCGA +GACCCCGGGGATACCGTAATTTTTGACTCAAAATTTAAACAATAAATCCG +TTAAAATATTAAAAAATTTTTAGATATTTTTCAAAAAGACTGTCGAAAAA +TTGTTTTTTTATAATTTTTAGAATATTAACAAACAGTTTAAAAATTCCAA +CAAATTTTGTTTTTCATACCGAAAAGAAGAAAAATGGACAAAATAGTAAG +CTATTTTTGTGTGTCAAAGTGTCTTATTTCGGCTTGATCTACGTAGATCT +ACAAAAAATGCGGGAGAAGAGACTCAGAGTTCTCAACTGATTTCGCATGG +TTAAGAACGTGCTGACGTCACATTATTTTAAGGCGAAAAAATCCCGCCTT +TTTTTGTAGACCAAACCGTAATGGGACAGCTTGGCACCACGTGACACCCC +CCGATTCTCACCTGTTCGTGATTTTGGCGAACTGCCATTTCTTTCAAATA +ATCGTCTAGCGGGGGACTCGATGCTGAAAAAAAAGTTTGATTCGTTAGAG +GAGCACAAAATTCTGAAAATGCGTATTGCACAACATATTTGACGCGCAAA +ATATCTCGCAGCGAAAACTACAGTAATTCTTTTTAAATGACTACTGTAGC +GCTTGTGTCGATTTACGGGCATCGATAGAATATTTTTAAAAAAGAAGAAA +AAAGAGGGAATAATACGAAGAAAAAAAGGAAAAAAATAAATTCATTTCAG +AAATCGAGTTCGTAAATCGACACAAGCGCTACTGTAGTCATTTAAAGAGA +TACTGTAGTTTTCGCTACGAGATATTTTGCGCGTCAAATATGTTGTGCAA +TACGCATTTTAAGAATTTCCAGTTTTTTCAAACCTTTAAACTTACATTTT +CGCGGTTTTTTGGCGCTCTCGGATTTCGGGGAACGTATACGTCGGCGACG +TGACGTGGTTGAAGCAGGGTCCGTCGAACAACATGGCTCTTCGTCTTCCG +ATACTTGGGATTCTGTTGATGTTGACGGTGATTCCTGAGGTTCCTCTAGA +GCATCTGAAAGCTCTTGCTCATCTTCTGATAAATCTCCATTGGGACGTTC +AACCAGGCCGGTGGTGGAAGGATCATTGATGTTCGGAATCATTACAATCT +CCATTCTCGGAGTATTTGGAGTTTCTGGTCGAGCTATCGAGGAAAGTATG +CGATGATGGCGGGGTCTATCATGATTAATCGTCCATTCGAGCACATATGC +TGGTGCTGGAAGGATTGAAAATTGTAAAAACTAAGATTTTTTGGCCAAAA +AAATAATATTTTCTCAAAAATTTTGAAATTCTCGACAAATATTTTTTACT +ACTGCCGGTACAGAGAATGTAGATAGTTGAAGAGACACAGACATCCCGGG +ACCCAAGGGACGGGGCGCGGGATGTCTGTGTCTCTTCAACTACCTGCACT +CTGTGCTGGTAATATACTTTTTCCAAAAAAAAAACCTACATTTCGGAAGT +AAAAATGGAAAATTTCGGAGTCTACACAATTGGAAATTTTAATTTTTAAA +AAATTAAAAATTGTTTTAATTCGGAGTTTTAGACGGAAAAAATTATTAAA +CTCTAAAATTTTTAAAAATCGAAAAAAAACAAGTCTGAGAGTGAAAAAAA +TTAATAAATTTTGAACTGAACATTAGATATTTCGATTTTTTTTTGAAAAT +CATAAATGTTTTCTCGCAAAATTCGGATTTTTTTTACCTGCTCGATTTTC +AGTAGCCGGAGCTGTATTTCTGAGATTGGCACCATCCAAATGTGCTCGGG +GCGCTGCAAATTTGATATGAAATTTCACTAAAAAATTAGGAACTTATACA +AATTTTCTAAAAGAAATACTAATGTTAAGATAATCGAAAGTTTGGAGTGA +CAGAAAAAATTGTTTCAGCTTCTAGAAATATTTTAATTTAGAAAAAAACT +TCCAGAAAATTAAAATTTTTTTTTAGAACTTTTGAACATTTTTCCTGATT +TTTCTTTTTTTTCCATTTTTTGGAATTGCTGGGAATTTCTCTTTTTTCCT +TCATCCCACAGCTTCGCTTCAGCCTAGGCCTAAGCCTGAGCCTGAGCCTA +TGCATAAATCTAAGCCTAAGCCTGAGCCTAACCCTATGCCTAAAACAAAG +CCTGGACCTAGGCCCAAGTCTAAGTCTAAGCCCACGCTCAAATTTAAATC +GACTCAAGTAACTACTTTAAAGTTGGCAGAAATATTTGAATTCAAAAAAA +TTTTTAACCAAAAAAAAAATAATTTAAAAGAAATTGTTTTTTTTAAATAA +AATCAACAATTCACCTGTAAAACCTTGCATTTCTCTCCAATTCAACATTT +CTTGAAGAACGTCAGTTCTTGTTTCATTCCATCGACGAACATGATCTGCT +ATAGTATTTCGAATATTTTGTTCATTGTTTTCTTGTTCTCTGGGATTATT +ATTACGACCCAAATATTGATCCATGACGTCATCCAAGTGATTACGGGTTC +TTTGATCTGCTGGGAATATTTATAAGCACTTTTTTAATTTAAAACATATT +TTTTAGTGATTTTTTTTCGAACTTTTGAATTTTGAATTAAAAAAAAAAAA +ATTAAAAAGTTAAATCCTGAGGGGAGCCAAGAAGTGGGCGTGTTTTAGGA +CATACTCTTCACTTACGCTTTGGTCTACAAAAAATGCGGAAAACTTTTGC +CCAAAAAATGTGACGTCAGCACGTTTTTAATCATGCAAAATCATTTGAGA +GTTCTGCGTCTCTTCTCCCGCATTTCTTGTAGATCTACGTAGATCAAGCC +TAAATGAGACACTCTGACACCACGTGGAAAATAAAAATCGAACATTTTCA +AAAAAATTACTCAATTGATTGTCTGCTGGAGTTAGTTGGTCGATTCTGAA +AAATATTAAAGTACTAAAAATTTTCCTTAGCAACATAGCGCGTTTGCATC +AAGAAAGGCGGGATTTTTCTAAGCCCGCCCTTTAATGGATCATCAATTTC +TAGGAAAAATCGATATTTTACACTAAAAGTGATCCAAGAAAATCAATAAA +TCGGAAAATTTTCCGATTTTCCGTGCTTTTTTGCGAAGATTTATCGAAAA +TGATTTCCATTAGAGCACGCTTGCAATTTTTTTCACCAATAGCTTTCAAA +TTTCTTACGGTCTTGGATCAAAAAGTTGTCGACGCCGATTCAACTCTTCG +AATTGTTCAGCTTGATGCCTTTGAACATGATCCATATACGTATTTCCACC +TTTCATCACCATTATTGATCCGCAAATCTGACGATTGACACGTGGATTGT +AGGCGTGTCGGCGAATGTCGCGGCGGAGTGCCTGACGCGCCAAGTAGGTC +AACGTGCGGGGACCACTAAAAAATCCGGGTTATTGTGATTTCGTGGTGAG +ACCCGAAAATAGTAGAATTTCCTCGTACATCCTGTGCCTAAGCAGGTTTT +CAGTTTTTGATGGGTTGTTACCTTCATACACCTACCTGCCTTTGTGACTG +CCTCCCTGCCTGCCTAAATGTGTGTATGCCTACCTACAGTCTGTTTATCT +GCCTCAACGCCTTCATACCTACTTGCCTACCTTGCTTACATACCTGCCTA +CGCGACTACCTATCGGCCTACCGGTTGGCAAGTAGGAAGGCTAACAGGTA +GGTAAGCTGGCAGGCCTGAAATTTGCAATTTTTGCGAAAAACCGAATTAC +CTTTCGAAAGGCGTAGGCGTTGAGATCCGTTCCTCCTTCGGAAGCCTGAT +CATTGGAGAAAATGTCATTCTTCCAGGGACGTCATACACAGTACGATGCT +TGGAAACTCTTCTGTATCGGCAAACCTGAAAACCTTTAAATGTGGAGGAG +CCAAGAACTAGACGGAGCCTGTGTAAGGAATATTGTTTCCGGAAACACGG +ATTTTCAAATTTTAGGCTCCACCCACTCACCACGCAAAATTTCATTTTTG +GCCCAAAAAGTAAATGTGCAGAAATTGTATTTCAAATTGTAGAAAAACCA +AGAAATGGGTGGAGCCTGCCTGCCTGCCGGGCTCCGCCCACTTCTTGCCA +AACCATACCCCCTGTATACGTGGCATGACGAGTTGTCCTCCAACATTCAA +CATTCCAAGCATTCGTTTCAACAACTGAGAATCATCGGCAACGAATCCGA +CAAAAATTCGATCATATCGATTTTGATGAGCTTCAAGAAATTTGACATCG +GTGATGTCGCACACTTTGAGCTCCGGCCGAGCCCAGCCGACAGAGCTCGC +TTCGGGTGTAGTTATCCATTGATCAATGCATGTTTCCGAGTAGGTGACGA +GATTCTCGTAGAGTTCGATCCCATGATTTATACCAGTTTCACCTTAAAAA +TAGGGTTGTCAGGCCACGCCCATTTTTAAAAAATGAATTAAAATTTTCTG +AGAAAAAATTTCAAACTTTGGTGGGGCATTAAATTTTTTCACATAAATTT +TTTCGGCGGTAAATTCAAATTTTTTAAAAAATTTCTTTTTTTTTTGGCGG +GAAATGTGCCGCAAATCAGAAAAACTGAAATTTCTACAAAAAAAGTTGGT +GGCCGAGTTTTCTCATTTTGTGGTCAGAAAACTCGGCCACCGATTTCTTT +TGCGGCCCTGTGATTACTTAAAAAAATCGGTGGCCGAGGATTTTTATTTT +CGCGGCCACAAGTAATGAAGATTGCACAAAATTGATAATAGGGAAAACGC +GGCCACGAAGTCTAACATGTGCCACGTGGCCGTTAAAAAAAAGCCGGTGG +CCGAGTTTTATTATTTTTCTAGGCCACGTAACCAGAACTCACCCAATAAA +ATGCCAGCAATCGTACTTAAATACCCTGAACCAGTTCCAATATGAAGAAA +CGAGTGTCCTTTACGCAAATCCAAATAATCGAATAATTTCGCATAAATAT +CAATTGCTCCAACACGAAGTGCTCCCGGATAGAATGGACCGCCCGGTTCT +GTGGAGGTCAACGACGGAAGACGTGTAAATTTCCGTTCACTAATCGGAAG +AAAATCGGATCGATCGACAAGTCGAAAGGCTCGTTCGATGTTTCGACGAC +GGATTGTGTCGTTTTTTACGAGAAAATCGATAAGATCGTCGTTTTGGCTT +TCACTATTGCCCATTTCTGGAAAATCGATTTTTTAAAATTTTAGATTTAT +TTATTGATTTTAAATAAATAATTAGAGAGCAGTCATGTGTTTTTCCTTGT +ATATTTACGAGAGAAATCTCAAAAAATTATTCAAATAGGAAATTTTACGC +CAACAATAAAATGTAGAGTGGTGTGCGCCTTTAAAAAGTACTGTAATTTC +AAACTTTTTGGCGCAAAATTTTAGAGTAGTTTTCTTTAAATTAAAAATTC +AAAAAAAAAACAAATCAAGATAAATACAAAAGTTTGAAATTACAGTACTC +TTTAAAGGATCACACCATTTTGCATTTAAAAAAATTTGTCATGTCGAGAC +CGTAATTTTAACGCAAAAAACGTGAATTTTCGCGTCTGTGTAAAAGAAGT +TAGTTAAGGAGAAAAAACAATTGAAAAATCAACAAAAATTGAACTTTCAA +CGGAAAATCAAAAATCGTTGCGAGTCAATAATTTTTTAGCTTTGAGGAAA +ATAACCCTTAAACTCAAAAAACAATTAATCGACTCAACATCAAAATTTCG +TTACAAGACCCAAATTAAAATTTTTTATTTTGGGATAATTGCTCCTAAAA +TTAATAAATTCCAGAGAAACGAGTAAATCGTGGCGAGACCCACTAGCGTG +TACCTTTAATTTCGAAATTATTTTGGGCTGTTCATCACGAACACACGTGT +TGCCTAGCTACCAAATTCAAAAAACGAAAAACAAAAAAAACAGGTTTCTT +TGAAATGAAAAATCGATAATCAGCAACGTGGCAAGATGTCTCAAATTATT +GGAAAAAAAAAACGTTGAAATTCTCAGAAAACGGACCGTTCTGTGGCAGA +ATTGTGAACGGCGTGCAAGGCCACGACCCGTGGAGAGCGCGTGAGAGTGC +AGAAAAAAGGAGGCGAGAGAAAACGGCTGACCCGTGGATAGACTTTGTGG +ATTCAGGAGACGCAGAGCGACCGTGAGAGACCCAGAAATATATGCAGAAA +GTTAAGGCGTGCAATAGTGTTGGAAATTATAATAAATGGGTACGGTAGGT +ATGACCTTTCGGGATCTTTGTGGGTCTCGCCGCGACGAGTTTTCAAGGTG +CATAAGGTTTTTGCGATGGGTCTCGTCACATAATTGTAGATTAAAATTGT +TGATTCGAGATAAATGGAAATTCGAAGCGTCTAAAACAGTTAGAACTTTT +AGTTTACATTAGGTTGAGCTCAACTGTCCAACCCCGTCAAACTTTTTCCA +CTTTTTTTTTACTTTTGCCTTTATGTCCTTTTCGGCCGTTTTCCTGGGGG +TTTTTACCAGACTACGAAATATCCTAACTTGGTAAGCCTCAGCCTAAGCC +GAAGCCTAAACCTTGGCTTTCAACTATACATACACATTTCCTCCTTTTTA +AACGATATTAATTAATTTACAAAACACCAAAAAAATATACAAAAAATGAT +TTGAATTTATGAGTTTCCCGCTAAATACCTACCGAGACCCAACTTTTGGC +CGTGGAGCGCGCTTGCACTTAAACTTCAATTTTTCACATCCCCATAATAA +CTTCCTTGTTTTAAATTGTTTTTCCCTATATTATTATTATCCTTATCACG +AGATGCCCTTGCAAAACACATTGTAAAAATAGTATTCTCAACTGATAATA +ATATTTTGTGTACCCCACGATAGTCCTTCTGGACCATAAAAATATTGATA +ATTACTGATAAGCTTTCTCTGTGGTTTCTGTAGTTTTGGTGATATTTTGG +GCAACAAATTTATATTATGGAAACACGGAATTCTGAAAATGCGTATTGCG +CAACATATTTGACGCGCAAAATATCTCGTGGCGAAAACTACAGTAATTCT +TTAAATGACTACTGTATCGCTTGTGTCGATTTACGGGCTTGATGTTGGAA +ATTAATTTATTTTCGAATTGTGACAGCGATATTCAGTTTTCCTTTGTTTT +TTTTTTTCGTATTATTTTGTTATTTTTATGCTTTCTTTTAATATTTTATC +AATTAATGAATGATTTCCGTAAATCGACACAAGCACTACAGTAGTCATTT +AAACAATTACTGTAGTTTTCGCTTCGAGATATTTTGCGCGTCAAATATGT +TGTGTAATACGTAAAGAAAGTTTGAAATAATTGTTTTTAAATAATTTCTT +ATTCATTCACTGTCAATTCTCACCGAAAAAAAAAATCCAAGTTCCTCCCG +CCAACTTGGCACGATGCCAAAAGGTTCTCAGGCCCATTCATGTCATTCAA +TCCATTCAAATGAACGACTTTTCGTTCAGTTTAGGCTTCTTCTTTTTCCG +GTTTAGTACTTTTTCAAACCGAAAAAAAAAATCCCAAATTGAATGCAAAT +GTGCTCTATTTGGAATAGACTTCACCCTATTTCGGAATTTTTTCCGATTT +TCTGAAAATCTTTAACACTTTTCTAACTGTTGCATTAATGACATTTTTCT +AGAAATTCTACTGCAAACGCGCTCAGTTGCGAAAGTTTTTGGGTCTCACA +ACGATTTCGGAAGAAAAACGTTTTATTCGTTGCGAGACCCGGAAGAGCCC +GGTGGAGCGCGTTTGCAATTTTTTTGGTTTGAAAATTTTGCGCAACGATG +CTCCAAAATAACACCTCGCGAATTTTATCGTTTTTTTAAATTATGACTTT +TCCGGTCCCAGAACGAATTACAAAAGCAATTTTTATGAAAAATCGTTACA +AGACCACAAAAAAAAGCGCAATAGAGCGCGTTTGCACCTTTTTTTCTTGG +AAAAGTCTCGTTTTTTTCTCGGTAAATTCACTGTGACATTGACCTTTCTC +GAAAAACGAAAAGTGTAATGGAAAGTGAACAAAAGTGACAATAATCTGGT +GAATTGCGTTTTGTTGTAATATTTTTGTATCTTCTTTTCTTTTTTTAATC +TGCGAAAAATAGAAAAGTTTTGGAGAGAAAGTGATTTTCGACGAAATTTT +CCTGATTTTGCTAAAATTGAACAAAAATTGTCATCATTTTCTGTGGGGTT +TCTCAAATGTTTTCTTAAAATTTATGCGCCTTTAAATTTGGGGGATTACT +GTAATGTTTGTATTTTTCAATTTTGTTTCGGGAACACAAAATTCTGAGAA +TGCGTACTGCACAATATATTTGACGCGTAAAATATCTCGTAGCGAAAACT +ACAATGGATTAAAATTTAATGAAATATCGTTATCACTATTCGAAAAGAAT +TTCATTATGAAGCCCGTAAATCGACACAAACTCTACTGTAGTCATTTAAA +GAATTACTGTAGTTTTCGTTACGAGATATTTTGCGCGTTGTCCCCGTAAT +AGTTTAACTTTTACCACGTGGCCGCCAGAAGAAAAACTTCTGCTACCGGA +TTTCATTTCCTCGGCCACAAACCCTTTTGACCCCCGAAAAAGTACATAAA +AACAATTCCGGGGACTGGGTCTCCAATCTCTCGCCCCCACTCACTAACAA +GGGGGACACCCTCAGAAACGAATGCCGTCTAACCGTCTGCACCCTCTCTC +TCGTCGCTCCAAATTCTTGGATCAATGCCAACTAACACGCAGTGTCCCCC +CTCCTCCTTCATCCACCCAAATGTTTCATCACTTCCCGGCCACCGCAGGC +TTCTCTCTCTTTCTCTAAATCTCTCATAAACTACTGTCTCTCTCTCTCTG +CTTCTTTTGCTCAATTGTTCTTCTTCATCACTACTATTTGCTCAATTTTC +GTAAATATTTTATTTTAAAATATCCCTTTTTCCTCCCCCCGCCTCTCTGC +TTCTCGCTTGACGCGCCACATACACTAAAAAAACCGGTTTTTTCTATCTC +TCTCCGCCCGATCATTGAATAGATAGTGTGTGCTGTACATCAAATTTCCA +TGGAAAAATCGCGCCGAAATTCCAGAAAATTCCACTTTTTCTAGAATTTT +CAGCGATTTTTTTCGGTTTTTGAATTTAATACAAAGCGAAATTCCGTGAA +AAATTAATTTTTCCTCAATTTTTGACGAATAAAAAATATTAGTATTGTTT +TTTTTTCAAGAAAGTGTGATTTTTTCACAATTTTCTATGGTTTTTACGGA +GAAAATCTTGAAATTCCACAGAAAAACTTGACAAGTCTTTGAAAATTAAT +AAAATTTCACCGTATCTGCCGATCGTTGCAAGACACACTCCACAAAAGAA +GTCGTGCGCCTTTAAACTGTGTACGGTAACTATATTGATTTAATTTTTTT +TTTCGATTTTGCGTCTATTTTTCCAATTTTTCTCTGATTTCGAACGATTT +TTTGCATTTTACCTCAAAAAAATTAATTTATTTAGATGATAAAGTGGAAA +TTGCTGATTTTTTACAAAAAAACACTTAAAAAACGAGTTTTCTCATCAAT +TTCAGTTGTTTCTGGCATGGCTCATTGTTTATCGACACCTGCTTGTTTTT +CTCCTCCTCTCCCATCAATTTTATGAGTTTTTCTTCGAAATTTCTCCATT +TTTCCCGTTCAAAAACCGCCAAAATTCGCTTTTTTTTTTCCAGAATTCGC +CTACTATAGCACTACTAGATGTGTTAATTTGGAATTATTTTTCAAAAAGA +AATGTATCCGGACGGGCTAACTGAAAATGAGAAGCTCAAAGTGAAGGAGC +TGTGCACTATGGTCAATATATCCGATGAGGATGCGATTAAATTGTTAAAA +GGTGGATAATTAAGCTGAAAAGTGGAAAAAAAAATGCATTTTTTACCTAA +AATTTACCTAAAAATTGGACCAAAACGTCATAAAAATACTGAAAAGTCAG +AAAATTGTCTAAAAAAACTAATTTTCGCTAAATAATTCCAGAAAACGACT +GGGACATTGCAATTTCATCGCGAAGAGTGTCGAAACAAGAGGATAAAACA +TTGGTTCCGGGCACTTCGAGAGGTAAATTTTTGAAAATTTTCAGAATCAA +ACTGAAAAATAGATATATTGTGTGAAAAAATCCATTTTCGCCGTAAGAAA +AGTGAATTTTGAGCGGTTTTTCAAATTTTAAACTGAAAAAAAAAATCAAT +TTATCTGAAATTTTGCTCTTTTCGGCGGGTTTTTTCTCAAAATTTGATGA +AAAAGTTCTAGAAAAACGACAAAAAAGCCTTTAAATGTACTTTTTTCTGC +GATTTTTTATCTTAAATTTAAAATTTTGCGCGTCAAATCTGGTGTTTTGA +CTCCGCCCACTAAATTTAAACTTTTCGTGAAAAAAAAATGTTTTTCTCCG +ATTTTTAATTGTTAATTTAGGCAAAAAAATACAAAATTTGCCCAATTCAC +CTATTTTTTCCAAAAAATCACAAACTTTGCGCGTAAAATCGGGTGTTTAT +GCTCCGCCCACAAAAATTTCTTAGAATTCGATTTTCGGCGGATTTTTTCT +CAAAATTTGATGAAAAATCTGAGAAAAACTACAAAAAATCTTTGAGCTTT +ACTTTTTCTCTGCGATTTTTATCTAAAATTTGAAGTTTTGCGCGTCAAAT +CTGGTGCCTTGGCTCCGCCCACAAAATTTGAAGTTTTCGTTTAAAAAAAT +GTTTTCACCACTTTTTCGCCGCTTTTTCGCCTGAAAAATCCCAATTTTTT +TGCAGAAGAAATCGATTTGGATCGATTATCGAGTCGTCTACGTGTTCACG +GATTAGCCTTCTATCTTCCAGATTTTGGAGGTTTTCCTAATGAATTTCGA +ACGTTTTTGGAGAAGGATTTGATAGAGACGCAGACACAGAAGAGACTGGA +GGCGTCCAGTAAGTTGTTTTCTGGAAAAATTGAAAAAAAAATTGAATAAA +AAAAATGATTTTTTTAATCGAAAAAAAAAGTTTTCAAAAATAAAATTGGA +AAAGGTGAAAAAAATTGAACAATTAAAAAAGAGCGACAAATGAATAAAAA +AAAACTTTTTTTTTTTCGAAAAAAAAGAAAACAAATGTTTTTTAATCGAA +AAAATAAAAAACGAAAAAAAAAGGAAATTTTTTTTACAATTAGAAAAAAA +AAATTAAAAATGTATTAAAAATTTTTTTTTTTGACATTTTCTTTCGCTTT +TTAATAAGTTTTGACTAGCGGGCCCTGCGGGCCCGCCAGTTGCAGGGGGT +GTAGGGCGAGTCCCCCAGTCGGGCGTAGGTTCTCGGCTTCGCCTCGAACC +TGTCAGAGGATTCGCGACAATTGCAGTGAGTCAATGGGAGGAGGGGAGAC +CCACTCATATTTTATAAAATCGAACATTTCTATTTGAATCCCGAGCACTC +ACAAAAAAACGAAAAAGTTTGTCAGTTGGGGGAATCGAGCAAAAGAGCAA +ATTATTCACAGCCATACGCACTAACCACTCGGCCATGCGGGAGAGACCTG +TCACAGAAATGTAGGGAAGGAAAATTTCTGGGGGGGGGGGGGGGGGGGGG +AGTTGTCTTTCGATTCCGTTTTATTCAATAATGACAATTTGGGGAAAGAC +GTTTGAAAACCGTTTATCACTGATAAGTCAGCAGGAAAACAATTTTTTGA +AATTTTTTTATAGCATTGTACTCATTATTTAATTCCCGAAAGAGAGCCGA +AAAGTTGAAGGTGTTATCTTGTAAATTGGTTTATTTGAAGAAAAAACAAG +TTTTGGCCTGAAAATTTTGAAAAAATAATATCTCTTGGCAGAGCATTGCT +AATGCGACGAAACTCCAGCTTCCATTAGATAAAATCAAAAACTATGAATC +AGAAATACATTCCGCAAAACTTTAGTGGAAAAAATGTTCAGGAGACCCAG +GAAACCACTCCCCCCAGTACTAAATTTTTGAATTATTTTTTCTTGAAAAA +TTTTCCCACTGAACTTTTTACAAATTTTATATGTCTCGATGCGTCTTGAT +GAGACCTACACGTCAATTTTTGGAAAACTAAGAAAACTTGAAAACTGACC +GAGTTATGATTGAAAAAGTAGATTAGCAAAGATGGGAAAGTGTGCAAAAT +TTGGCACTTATTCGTCTTGCTCGGCCGACTCATAGTACTTTTTCCAATTC +TGAGTTAAAAATCGTGTTCAGCGTACTTTTGTACGTGGGATAAAGAAAAA +AAATATCAAAAAAGATGAAGTAGAACTTGAGATAAAGACGAAAAACTACT +TTTTCGGAAAAAATTTTTTTTTGGCAAAATGGCATTTTTTGGCCTTTTGT +TTTATCACAACTTTTTGCCTTTTGCACTTATGAACTCAAACTTTCTTTCA +AAAAATCCACCTCTCTGAGTAGTATCTTGCACATAAATTTGGAACAAAAC +CGAGCAAAACCCGAATTTTAATTCAATTAAAACATGGTTTTTTGGGGGTA +AAAAAAGCAACAAAAAATTTTTTCAAACTGGGGAAAGCCGCCCTGAGCTC +AGTTTTGCTCCAAACTTTGTGCAGTTTTTTGCTCCCCCGTGGGGTGAAAT +ATTTCTAGTAAGCTGTCAAATATTACAAAATTCAGTCAAACGGCTCTGGA +GTTATTAATGAAAACGCAGTGTGACATTTTTTCGCAAGCCAAAAAAAACG +CGAAAAAACGCGAAAAAGGGGCGGAGTCTGTACACTCGGCATTTATTAGA +GGCTGCTTGGCAGATTTTGAAATATCGGAAAAACTTTAAAAGTTCTTTTT +TTTCCAGGACACCTAAACTGGTGGCATCAATTCGGCCAAAAACTCTACCC +GCTATCAACTACTGGAGACGGAAATTGCCTTCTTCACGCCGCATCGTTAG +GTAAATGGTTTTTCAGAGCGAAAAATCGGAAAATCGCTAAAAACTTACTA +TTTCCACTGAAAAAATTGTAGAGATCGCTCAAAATTTCACTATTTTCTGA +ACATTTTGATAAAAAACGACAAAACTATTTCAAAACGAGCCCCGAAAATT +GTTTTTTTACTAAATTTTTTTTGGAGAAGTGCAAAAATTTAAATTTTTGA +ATTAAATCTTTAAATCTTCAACAAAATTTAATCGTAAATTTTCAGGTATG +TGGGGAGTACATGATCGTCAGCTATCACTTCGTGAAACTCTCTACGAACT +TCTTACAAATGGCGCCAGAAAAGAAGCAATCCGACGGCGATGGAAATGGG +TTGAGAATCATATGAATCAGGTAATTGGCGAGAGAAGAATCTGTGAAAAA +TTTCTTAAAATTCGGTGAAAAATGATCAAAAATGAGCTGAAAACCGGTCA +CGTAGTTGAAATCCGCGGAATATGAAATTCCCAGAGGAAACAATTTTCGT +GGATTTCAACTTCGCGAATTTTTCTCAAAAAGCTTGAGTAAAAACTCACG +GAGTTGAAATCCGCAGAATTCGAAATTCCCAGAGGAAACAATTTTCGTGG +ATTTCAACTTCGCGAATTTTTCTCAAAAAGCTTGAGTAAAAACTCACGGA +GTTGAAATCCGCGGAATTCGAAATTCCCAGAGAAAACAATTTTCGTAGAT +TTCAACTTCGCGAATTTTTCTCAAAAAGCTTGAGTAAAAACTCACGGAGT +TGAAATTCGCGGAATTCGAAATTCCCAGAGAAAACAATTTTCGTAGATTT +CAACTTTTCTAGATTTTTTGCCAATTTTTTATTACATGTTACAAAAAAAC +GGCTGTAAATACTCACGGAGTTGAAATCCGCGGAATTCGATTTTTGTAGA +TTTCATCTTTTCCAGAATTTTCCAACAAAAAAAACCGGAAAAAATTATCC +GACACTCCATGGAATCTAGTTTTCGGAGATTTCAACATCGAGAACTTTTT +TCGCACATTTTTTTGCATTTTTAAAAAATTTCACCAATTTTCCAATTAAA +ATTTTTTAAATTTCCAGAGTAACGGTCTCGCATTGACCCTCTCGGAAAAT +GAATGCTTGAGTAAAAACTCACGGAGTTGAAATCCGCGGAATTTGAAATT +CCCAGAGAAAACAATTTTCGTAGATTTCAACTTCGCGGAGTTTTCTGTCA +ATTTTTTGAGATTTTTTCTCAAAAAGCTTGAGTAAATACTCACGTAGTTG +AAATCCGCGGAATTCGAGATTCCAGGAAATTCGATTTTCGTAAATTTCAT +CTTTCCCAGAATTTTCCAATTAAAAAAAAACGGAAAAAATTATCCGACAC +TCCATGGAATTTAGTTTTCGGAGATTTCAACATCGAGAACTTTTCTCGTA +GATTTTTTTGCATTTTTTAAAAATTTCACCAATTTTTCAATTAAAATTTT +TTTAAAAAATTTTCAGAGTAACGGTCTCGCATTGACCCTGTCGGAAAATG +AATGGGAACTCGAATGGGATGTTGTACTCGGATTATCATCTCCATTACCC +CGTAAACAAGAGGATAATGGCTCAAATTCCACAGATCAAATCTACGAGAG +TCTTGAGGCAATCCACGTGTTCGCGTTGGCTCATGTGCTCAAAAGACCAG +TTGTGGTTGTATCGGATACGGTAGGGAATTTTAAAATTTTTTAATTCTTC +AAAAATTTATTGAAGAGAACAGTAACAAAAAATTTGGTTACTTGTGAATT +TTACAGAAATATAGAAAATTTTAATTTAAAAAAATTTCGAGATTGGTGAG +AATCAAGGGTGTCAAGTCCCGTGTCCCGTTTGTCCCGTTGTCCCGTTTTT +TGAGTGTTTTTACGGGAACGGGACGTCTTTTGTCCCGTTTTTGAGCGTTT +TCACGGGAACGGGATGTCCCGTTGTCCCGTTTTTTGGGTGTTTTCGCGGG +AACGGGACGTCCCGTTGTCCCGTTTTTAAAATTTTCACGGGAACGGGACA +TCCCGTTGTCCCGTTTTTGTCATTTTTACGGAACATTGACACCCTTGGTG +AGAATAAAAAATCAATAATACACATAATTTTTGGAAGAAAAATCGATTTT +AAAAATGAAGCTTAACATTTTTTTTCGAAAGAAAAAAAGTGTAAGAAGTT +TATCAAAAAAAAAAACATTGAAAAAAATATCTTCAAAAATGTTCAATTTT +GTTTTAAGGTGCAACTATTACAAGAGCACACAATTCTTAGAATACGTATT +GCGCAACCTATTTGACGCGCGAAAACTACAGTAATACTTTAATTGTCTAC +TGTAGTGCTTGTGTCTCGATTTACGAGCTCGATTGATAGAATATTCAAAT +AATTTATTTATCGATTTAATATTCAAATTAGGCAAAAAATGAGAAAAAAT +ATACATGTGAAAAAATTAATTTTAAAAATAGAGCCCGTAAATCGACACAG +TAGTCATTTAAAGGATTACTGTAGTTTTCGCTGCGAGATATTTTGCGCGT +CAAATTTGTTGCTTAATACGCATTCTTAGAATTTTGTGTTCACATAATAC +GGTTTTTCAAAAATTTTAAATCTTCATAAAATTCATCAATAATAACTAAA +ACTTAATCAAAAAAAAATTTAATTTTAGTGTAGTCATCAGAAAAAGTCCA +TCAAAAAAAGTCCATCAAAAAACCATCAAAAAAAGAAAATTGAAAAATTT +GAATTAAAACATTTTTTTCGAATTTTTGAAAATAAAAGTGTTTGAATATT +AAACGTAATTAAAAAAAAAGATTTTCCTTTTTTAGAAAAATCTATTCATA +TTAGAACAGTCGATTTTATAAAAGTATCGATTTTTTTATTAATTGGATTT +TTTGTAAAATAATAATCGATTTTGAAAATAAATTGCTTAAAATATTGTAT +TTTTTGACAGAAAAAATGTAAAAAATTTATCAAAAATAAATAAAATTGCA +AATAATTTTACCTACAAATTAATTGTTTATTAAATAAAGTTTAAATAAAT +TAGAACAGGAGTAAAACGAGTTTTCAAAATTATTCTTTAAAATCTCGGGT +TCTTTTAATTCAAAAATTCTTTTAAAAAAAACTCAATAATTACGGATTTT +TCAAAAATTCGAAAAATTCAGAAATTCAGAATTTGGATAACATAATTCTA +GTTGACTTCCAAAAAAATGATATGTGACTTACTTAAGGTACAACTAACAT +TAATTTTCCAAAATTCTTATGGCTGCTTTAAAACACGCCAATGGGGTCAT +AATGACCGAATATTATGTTTAAAAAAATCAAAAAAAATTTTCTGATTTTA +TATGATTTTTTGAAAATTGGAAAAATCACAGTTTTAACCTAATTATTTTT +GAATTTCTGCCAATTGGATTTGTTCGGTGCAGCGCGCTTGCATTATTTTT +ATTTATTTATTTTATTTATTCTCGTTATTTCACTGATTTTCTTCATTTTC +TATGTTTTTTTTTCTCGGAAAATGAAAGAAATAAACAAGACAAATGCGAA +ATGTTTGTTAAAAAGTAATTGAAAATGCGTAAAACTGTGATATTCTGAGT +TCCGACGACGAAGAGCCTGAAATTAGTATATTTTTCAGTTTCACTCATTT +TCAATTACTTTTAAACAAACATTTCGCATTTTTCTTGTTTATTTCTTCCA +TTTTCTGAAGAAAAAACATAGAAAATGAAGAAAATCAGTGAAATAACGAG +AAAAATATATATAATTCATTAAATAAAAATAATGCAAGCGCGCTCCACCG +AACAAATCCAATTGGCAGAAATTCAAAAATAATTAGGTGAAAACTGTGAT +TTTTCCAATTTTCAAAAAATCATATAAAATCTAGAAAATTTTTTTGAATT +TTTTTATCATAATATTCGGTTATTGTGGCCCCATGGGCGTGTTTTAAAAC +AATTTCCCCACTGAGCGTAGTCCACCTTTGAAATGTTCTCAAAAAATGAA +AAAAAAACGAGTTATAAAAATTATTTTTTAAAAATCCAATATTTTAAATT +AATTTTTTTTTGCAGATTCTGCGAAACGCGAAAGGCGAAGAACTGTCTCC +AGTGGCTTTTGGTGGAATATATCTTCCATTAGAATGCCCACCATCACAAT +GTCATCGTTCACCACTTGTTTTATGCTATGATTCTGCTCATTTCTCACCA +CTTGTACTCATGAGAACAGAGACTAACAATAAACGTAAGCAATTTTTTTT +TTGAGAAAAAATATTTTCAAAATCATTTTTTAACTGAATTTTCAAATTTC +CCCCCCCCGTCCCCCCCATTTTTTTCGAAAAGTGAATTGGAATTTTCCTG +AAATTTGCACAAATTTTTTTTTGAAAATTCAAATGTTCGTCAAATAATTA +TTTTATTCGAAAAATCGACATTTTTCCAAATTGTAATATTTTTATTCTAA +AAATCCAAAATTTGATTTGGTAAAATTTCTGTCAACAATCAATTAAAAAT +CCAAAATTTTCAAAAAAATTGTGATTTTATTCGGGAAATTCGAAATTTCC +TATTTAAAATTGGATAAATCTAAAAGTTTTCGATTTTATAATTTTTAGGA +AAACAAGTTTTCAAATTTTTTTAATTATTAAAGTTTTTTTTTGCAATTTC +ACTAAATGAGCCAAATTTTAAAAGTGGAGCACCGAAATTTGAGACTTTGC +TTTTTTAGACTCAAATTGGTCCAAAACTACCGAATTTTGTAATGATACAT +TCTGAAAATTTCTCAAAAAAAAGTTATGGCTGTTTAAAGTTCGGCAAAAT +AAGGCCCATTTTCAGCTAAAATCAAAATTTTTTCCAACTTCTAGGTGTCG +CAACGTCTGGACCCTAATTTTTATTTATTCATCACTTTTTAATAAATATT +GTGGCCTTTGATTGGGCGTTTAATCGTTGTTTTAAGTACATTTATGATCT +TTGGAGTACAAATAAACGTTACATTTTGTACCCCAAAGACCATAAATGTA +TTTAAATCAACGATTAAACGCCCAATCAAAGACCACAATATTTATTAAAA +AGTGTTGAATAAATAAAAATTAGGTTCCAGACGTTGCGACACCTAGAAGT +TGGAAAAAATTTTGATTTTAGCTGAAAATGGGCCTTATTTTGCCGAACTT +TGAACAGCCATAACTTTTTTTTGAAAAATTTTCAGAACGTTTCATTACGA +AATTCGGTAGTTTTGGGCCAGTTGGGTCTAAAACAGCAAAGTCTCAAATT +TCGGTACTCCACCTTTAAAGAATTCATATAATTTTCTAAAACAACATATT +CTGATTTACAGAAATACATTTAATATCAATATGAATTATTTGAAAAATCA +AAAAATTTATATTTATTTTCAGAAATAATTCCGATAATCGATGTGAACCG +TAACCTGCTGCCTGTCCATTTTGCAGTTGATCCAGGAGAGTCATTCGATT +GGTCCAAATTAGAAACAAATAGTAATACACAGACAACTACTGATATGTCA +CAAATTGATAAGCTTGCGTTGATTAGTCAATATATGGATATTATTAGGTA +AGAAAATGAGAAAAAGGATTTTTTCAATTTTTTTTTCTAAAAAAAATATT +CAAAATATCGTTAAAAAGCCAAAAATGTGTACGTTTTAATTTAAAAAATA +TTAAAATTTTTTTGTCCCAAAATTAAAATATCGAAATCAAAATGTTTCCG +ACATTTATATAGAAATTCTGGAAATTTTTTTAAAATCGAAATCATATTTT +GAATGAAACTACAGAAAACAGCGCCAAAAAAGAAAAAAAATCGTTTTTTT +TTTTCGAATCTTTCATTACAAATATTTGAAAAAACGATACAATTATGTTT +CGCGAAAATTTTTTAAAAAAACTTTAAAAAATTATTAAAATCAGCTATTT +AATCACAAATGAGAAATATATCGGAAATCTGGAAAAAATTAAAAAAATTT +TTTGCGTATTTGTCTGAATTTATTTTACAAATACCAAAAAAAAATCAATT +ATTGTTGGAAAAAATTGAAATACAACGGAAATCGAATTATTTTTATTTAA +AAAGAACGAAAAAAAATCCAGAAACCATCACAAAATTATTGGAAAACGAG +AAAGCTGATTTTTCGCTAAAGTTCAAAAAAATTTACAAAAAAAGAAAAGT +ATTAAAATCGGTAATTTTCCCAGCTTGAAAAACTGAAAAATTCGAGTTTT +CTAAAAAAAATTAAAAAAAAAAATCAAAATATTCCTCAATTTTGGAAAAT +TACGGAAAAAGTAGTTTTCTTTAGCTTTCGGCCAAAATTTTATCATAAAA +ATTTCCGGAATGCATAGTTTTAGAGAATAATTTTAAATTGAAACACTAAA +TTTTTTAAAAAACTTTTTTTTTTGAAAATCCCGGATTTAAAAAAAAATAA +AATTTGAATTTCATATAAATATTTTGTTAGGAAAAATAGTTTCTAAACAA +AAATTTGAAAAAAAAAATATTTTTTTTTTCATATTCTTTGAATAAAAAAA +ATCTGAATTTCGAAACATTTCAGATTAGACGTTCGTCGTGGCTCAATCCG +TAGCTCGCGGAGAGTTCGAAGTGCTCACGCGCAACTTCTCACCGAATCTC +GTGGTGAAAATGGGCAAAATTTGCCCCAAAAATCAATTAAACCAAGAGAT +TTAAGTGCACATTCTAGTGATGAACAACCATCAAATAATGCAAAAGGAAT +GACATTAGCATCAAGTGGAATTGGTTCTGGAAGACATGAGAAATGGAGAT +TAATCAATGAAATTCGGTAAGCATTTTTTTTTTGGATTTTTGGCCTGGAA +AAAATTTTTCCAACAAAAACTTGAACAGAATTTTTGAAAAAAATGTTGGA +AAATTAAAAAAAAATTTTTTAAAGTAATCAATTTTAATTTTAAAAATTAG +AAACTTTTCAAATAAAACATTTTTATTTTTTCAAAAATTTTGAATTTCAT +TTTCAGAATAATCATTAATGAAAATTCAAAAAATTCAAACTACAATACTA +CGATAACAAAAAAAAATCAGAATGCGTACTACGCAACATATTTGACGCGC +AAAATATCTCGTAGCGAAAACTACAGTAATCCTTTAAATGACTACTGTGT +CGATTTACGGGCCTTGTTCTATTTTTGAAATTAATTCATTTTCGAATAGT +GACAGCCATATTACATTTTTCTTCGCTTTTTTGTATTATTTTCTCTTTTT +TTTTGCCTAATTTGAACATTCTATCAATCGAGCCCGTAAATCGACACAAG +CGCTATAGTAGTCATTTAATGAATTACTGTAGTTTTCGCTACGAGATATT +TTGCGCGTCAAGTATGTTGCGTAGTACGCATTCTCAAAATTTTGTGTTCC +CGTAATATGGTAGTTTGAATTTTTTTAATTTTCATTAATGATTATTCTGA +AAATGAAATTCTAAAGTTTTGAATAAATAAAAATGTTAAAAAATTTTTAT +TTGAAAAGTTCCTCATTTTTTCAAATTAAAATGGATTACTTTTAATTTCC +AAAATTTGTTTACAAAAAATTCGTTTAAAAAAAAATTAAACTGTTAAATG +TTAAACTTTTCAAAAAAAAAGTTCAAAATTTTTCTGTAAATTTTTAAAAT +GATACATGTAATTTAGATTATAATTTAAAAAAAAGACAAACATTTTTTGA +CGAAAAATATTAAAATTTTGTTAAAAAATGAAAGTTTTTAAAGCCTAAGC +CTTAGCCTCAGCCTAAGCCCAAGCCAAAGCCCAAGCCTAAGCCTAAGTTT +GGTACTGCAGTATTTAAAAAAAAAGTTTTTCCCCAAATTTCTTCTGTTTT +CTTAAAATTCAAAACTGTTATTTGCAAAAAAAAATGTTTTTGCAAAATTT +GAAATTTATTGAACTGAAAAAAATGTGAATTTTTTAATTGCCTTTGTCGC +AGCGGCTGGAAACAATTTTTTTTTTGAAATCAATTTTAAGAATAAAAATT +GATTATCTTGCGTTTTAAACTTGATTAGGGTATTTAAAAATCGATGGACG +GCGAGTTTTGGTTCAAAAAAATTAAAAATCTCGCCGTCCATCGATTTTTA +AATACCCTAATCAAGTTTAAAACGCAAAGTAATTAACTTGTATACTCGAA +ATTTGACGATGATTTCAAAAAAAAATTGTTTCCAGCCGCTGCGACATTGA +TAAGTTGGTCAAATTTCCGATTTTAACTAATTTTAGGCCATTTTTTGAGC +CGTCATAACTTTTTTCTGAAAAGTTTTCAAGAAGTTTCATTATAAAATTC +GGTGTTTTCAGACAATTTTGAGTCTAAGAAGCCAATAAAAAATTCGACTA +CACCACCTTTAAAGCTCAAAATAACGTCCAAAAATTCAATTTCCAGAACC +CACGTGCTTCGAACTTTTCGTATTTCCTCATCAACACGTGGCAAAGAGAA +ACTAATCGATACGGACGATTGTATTGCAAGAATGAATTCGACGTGCGTTC +TCGCATCGGAATTATTGCCAACTCATCACCAATACATGGACAAAATAATC +AATGAATACATGAAAAGTGCGAAACAACGATTCCAACAGAATCAGCGAAC +ACAATCGGATAGTCGGAAACGGATTAGTCGAAGTTTCAGTGCAAGCTCAC +TTATGCTCACGTGTATCGGTTGTGATTCGGTACGAGACCCACTTTTTGAT +GGAATTTCGAGAAAAAAGTTGAAAAAACGGAGAATTTGGCACAAGTAGCC +TCAATATTTGAAAAAAAAAACCGAAAAAATGGATGAGGGGAAGCCAAAAT +ACCAGAATTTACACCCAATTTTCAAAGTTTTATTGATTTTTTACAAAAAT +TTTCTCAGTTTTTCAGTAAATTTGCCAGATCTGACCATTTTTTAGGAAAA +CTGAAAATTTTCGGTGTTTTGCCAGAATAGCAACTTCCTGAAAATTTAGA +ACTAATTAATTTTTAATTTTTTGGGGGAATCATTTATTTCCTAACAGAAT +TTGATTTGAATTTCGAAAAAAACCGATTCTAAGCTTAAAAATTGACAAAA +ATAGCAATGAATGTCAAAAAAATTGCTAATACATAAAAATTGTTTGAAAA +AATACAAAAATAACAATTTTTATTTAAACTTTAAAAATTTTTCAAATTTT +AAAAATTGAAAAAATTAAAAAATTTTTAAATTAAAATTAAAACATTTTTT +GTTAAAATTTGAAAAAAATTCAAAAAAAAAATTTACATTAAATTTTTTTT +TTCAGGAATTCAAGCCGGCATCTCAAGTGACAAATATCATGTGTGATCAA +TGTTTTGCTTGGCAAAAAATGAGTGTTCTCACGTCGAATTGCGACCAATT +TATGGGAAATTCTGGGCCACCGTGCAAAAGTTCAACACTTCCGTCATTTG +GTAGTAATGATAGTAATCAGAATGATAAGGAAAATATTGTGGAGGTACTT +AATGTGGTGCCTAAAGATGGAGCCAAGACACTTACCAGGTATGGTTGAAA +TTTTGAAAAAATTAGAATTTTCAACGAAAACAGAAATTATTTTAAAAATT +TATTTTTAATTGAAAAATAAAAATTTCTCCCAAAAAATTTTCCCAAAAAA +AGTGTTTATGTTATTTTTGAAAATTATAATTGAATTGATTTTAAAAATTA +CGAGAACACAAAATTTGGAGAATGCGTATTGCGCTACATATTTGACGCGC +AAAATATCTCGTAGCGAAAACTACAGAAATTCTTTAAATGGCTACTGTAG +CGCGCTAGTGTCGATTTACGGGCTCTATTAACGAAATGAATTAAAATCAT +TTAGTTATCGAATAATACAAAAATCATTTCATTTCGAAAATCAAGCTCGT +AAATCGACACAAAAGCTACAGTAGTCCTTTAAAGGATTACTGTAGTTTTC +GATCCGAGATATTTTGCGCGTAAAATATGTTGCGCAATACGCATTCTTTG +AATTTTGGCTTCTCGTAATATACGAAGGTTGAAAATTTCAGATTTTTAAC +ACAAAAACTTATGAAAATAAAATTTATGAAAAGTATAAAAAGTTGAGAAA +ACAGAAATTTTAATTTTTGCGAAATCTAGATGTCAATTTCTTCACAAAAT +TTTTCAAAAATCGATTTTTCTTTCGAAAATTTTTTTTTGTAATTATTTTA +AATCAAAATTTGGCGATTTTCAAAATGTTTATTTTATATTTAATTTCTAA +AATTAATTATTTTGATTAAAAAATATATAAATTCAATTTTCAGATTGTAA +AATGAATTTTTTTGAGTTTGCCGTTGAAAAATAGAAAACAAATTATTTTT +AATAACTGAAATAACTGAAAATGTTGTTTGAAAAATTACATTTTTCCAAA +AAATCGAACATTTTTGACGCGCAAAAAAATTTGTAAAAAAAAATTTTCAA +CAGAAAAAACTGTAAAATAGGAAAAAAATTTACCTAAAAAGCGTATGTGC +CTTTAAAATGTACAGTAACCCCAAAAAAATCGATTTTTTGCAGTATGCGA +GCTGTGGAGGACGAAAACGGTGTGGTTCACTATTATATGGACGATGAAGT +AGCGGATTCGTGATTCTATTATACTCATTTCTTTTTTTGAAAATATATTT +ACTAGAGACCAGTTTTCATTTGATTTTTATCGATTTTTTTTGGATTCCAA +ATTTTTGTTTTTTTTTTGTTGCTTTTTGTGTGTTTTTTGCCGTCTATCCT +TCTTTCCTGCCAACGGGATTTTCTCTTCTTTTTTTTTTTTGAAAAACTCA +ATTTTCCCGCCTAGTATTGCTTTTTTCGAGATTTTTTCTTCCATTTTTCA +TATCCGCGCCAGCTTTTTCTCTCCCCTCCTTTTTTCACCCATATTTTCGA +GCTTTTTTCTGTGATTTTTTTTTCACCCCCAAAATTTTTTGTACCAAAAA +ATTGATGCTTCTTTTTTTTCTCTTTATTTCCAACAAAATGCTTGGCCAAA +GAAATAAACTCTTTTATAATTTATCATTCAAAAAATTTGAGACCAAATTG +AAATCCACATCCAGCAACTGCAAAGTGTCATTTGACAATGCACAAATCGC +ATGGCACGCCCCGTTTTCGTCGATCACCCGGGAACGCGTATTCTGGGACC +AAATGAGGAGGCGGTGGCGATCGGAGAAAATGAAGTATGGACCACATCTG +GAAGACACACCTGATTTTACGCGCAAAAATTTAGAAATGTATCGATTTTT +CGGTCAAAAATCAATATTTATCGATTTTCGGAGGGCACATGGGCTTCTGG +CCTTCCTCATTGAATATTCGCGCTCCATTTACACTCGCCTGCCGGACAAC +GCGTGGAAAAGTGTGGTGTACTCCACACGGACAAATACATCAGTTTTACA +ACTAAAATCGAGCCGTGACGCGACACGCAACGCGCCGTAAATCTACACAA +AATCTCTCCGACCCAAAATGGCCTAGTTCGGCAAACTCTGCCATTTCGAT +TTATGAGGGAAGCCAGAAATCCGTGAGGGCAAAGATTGAACAATCTGAGT +TAAATCGTTTCCATACAAAATTTTTTGAAAATTTTATTCTGAAACTGTCT +AAAACTCGAAAAGTTATCAATTTTCTGGTTAATTTCTGAGGAAATTCAAA +AATTGATATTTTCGAAAAAAAAAATCGGAGCCAATACACATCATTTGACG +CGCAAATGTTGAATTTTCAAATTTACGAGAACCCACGGGATTCTGGCTTC +CCTCATAAATCGAAATGGCAGAGTTTGCCGAACTAGGCCATTTTGTGTCG +GAGAGATTTTGTGTAGATTTACGGCGCGTTGTGTGTCACGTCGCGGCTCG +TTTTCAGTTGTAAAATTGATGTATTTGCCCGTGTGGAGTACACGGCACTT +TTCCACGCGTTGTCCGGCATTTGTCAATGGAGCGCGAAAATTCAATGAGA +AAGGCCAGAACCCCGTGAGAATCCTAAAATTCTGAGAATGCGTATTGTGC +ATCATATCTGACGCGCAAAATATCTCAAAGCGAAAACTAGAGTAATTCAA +TAAATCACTACTGTAGTGCTTGTGTCGATTTACGGGCTTTCGAAGAAGTT +ACTTTTTTAGTTTCTTCGTATTATTTTTTTTCATTTTTTGTCTAATTTTA +ATATTCTATCGATAAATGAATGGGTTTTTATTTATTTTTATTATCGAGCC +CGTAAATCGACACCAGTGCTACAGTAGTTTTCACTACGAGATATTTTGCG +CAATATATTTATAAAAGTTGACTAGCGGGCCCTGCGGGCCCGCCAGTTGT +AGGGGTGTAAGGCGAGTCCCCTTGCCGGGCGTAGGTTCTCGACTTCGCCT +CGAACCTGTTAGAGGGTTTGTGAAAATTTCAGTAGGTCAATGGGAGTCTT +CTTGTTTTTTGAGTTCGGTTTGACCAAAAACAGATGCACCCGATGAATCA +GTTAAAGCTGAGTTTTGATTGATTGAAGTTTGAGGAGGCTTTATATTAGG +GGAGACGTACCCATATTTTGTATAAAATTGAGTATTTCTATTCGAATCCC +GATTACTCACAAAAAAACAAAAAAAATTGACACTTGGTAGAATTGAACCA +ACTACCAAAATTTCTGCAGTCATACGCACTAACCACACGGCCATGCGGGA +GACACCTCAAACTGGGATGTAGGGAAGAAAATTTTCTGGAGGAAGTCGTC +TTTCGATTCCGCTTTCTTCAATTATTACTATTTGGGGAAGACGTTCGAAA +ACCGTTTATCACTGATAAGTCAGCGGAAAACCTAATTTTTGAAAATTTTA +TCACAGGATTGTACTCATTATTGAATTCCCGAAAAGGAGACGTACAGTTG +AGGGTTATATCTTGTACACAGACAGATGTATAGAATAAAACAAGTTTTGG +CCTGAAAATTAAAAAAAATAATATCTCTTGGCAGAGCATTGCTAACGCGA +CGAAACTTCATCTTCCATTAAATAAAATCAAAAACTATGAATTAAAAATA +CATTCCGCGAAACTTTAGTGGAAAAAATGTTCAGGGGACCCAGGAAACCA +CTCCCCCCAGTAAAAAATTTTTGAATTATTTTTTTCTTGAAAAATTTTCC +CACTGAACTTTTTACAAATTTTATATGTCTCGATGCGTCTTGATGAGACC +TACACGTCATTTTTTAGAAAACTAAGAAAACTTGAAAACTGACCGAGTTA +TGATTGAAAAAGTAGATTAGCAAAGATGGGAAAGTGTGCAAAATTTGGCA +CTTATTCGTCTTGCTCGGCCGACTCATAGTACTTTTTCCAATTCTGAGTT +AAAAATCGTGTTCAGCGTACTTTTGTACGTGGGATAAAGAAAAAAAATAT +CAAAAAAGATGAAGTAGAACTTGAGATAAAGACGAAAAACTACTTTTTCG +GAAAAAAAAATTTTTTGGCAAAATGTCATTTTTTGGCCTTTTGTTTTATC +ACAACTTTTTTCCATTTGCACTTATGAACTCAAACTTTTTTTCAAAAAAT +CAGTCTCTCTGAGTAGTATCTTGCACATGAGTTTGAAACAAAACAGAGCA +AAACCCAAATTTTAATTCAATTAAAACATGCTTTTTTGGGGGTAAAAAGA +GCAACAAAAAATTTTTTCAAACTGGGGAAAGCCGTCCTGGGCTCAATTTT +GCTCCGAACTTAGTGCCGTTTTCTGCTCCACTGTGGGGCAAAATATTTCT +AGTAGGATTTCAAATATTAGAGCATGAAGTCACACGGTTCAGGAGTTGTG +AATGAAAACGAAGTGGGACATTTTTTCGCAAGCCAAAAAAAACGCGAAAA +AACGCGAAAAAGGGGCGGAGTCTGTACACTCGGCATTTATTAGAGGCTGC +TTGGCAGAAAATTATCAATTATGTATATGTATAAGAATTATATTCGAATT +TCACGCGTAAGTTCCAAATTTAGCAGCATAGCCGCCTGAAGTTCGAAATT +TAAAATAAAAAAACCGAAAAGTACCTGACAGCCAACGTGGCAACAAATGG +AATCTCATCGACAAGTCCTTCAGAATTGAATACTGCAGCATTTGACGTAT +GATAAATGACTGCCACGAATTGATTTTCAAATAATATTTTATTGATTGAC +GTGGCAGTTTGGTGGCTGAGCGGTTTGTAGTCCAATGTTGGTAGAGTTAA +TAGGTAAAGACCACCCGTCTCGGTTGCCACACACGCTTCTTCGCCGCTTC +TGGAAAATTTGGTTTTGAATTTCTAGGCCATTGGGTTAGGCTTCGTTTTT +GAAATGGGTTAGAAATGTAGAAAATGGAAATTCTAGGCCATCAATTTTCC +TTTTGCATGTGTGTAGGAAATTGGCTAACATTCTAGAAAATCGATAATTT +TATAGAAAGTGAAATTTTCGCAAAATCAATAATTCGATAAAAATCGATAA +ACTTTGATAGAATTTTGTTCATCAAAAACCGATAATGTCCGAAAAATTTC +AGAAAATTAGATTTTTTTAACAGTCCGTTCATTTCGTGGCCTAGAAACTT +ATTTCTAGGCCATGGAAGAGTTTTTCCAAGATTCACGGCCACACGTACAC +TTGCATGCTAACAATTGCGACAGGCTTATTAGAAGTCGAAGATCTTCGAA +TTTTTCGCGACAGATCCGACACTGTGAGCTTTGTCCCGCCGAGTTTTTCG +AGTCCTGATGTTCCGATTTGCCATAAAATTATATTACCATCGTCGGAGCC +TGATAAGAGCCCGTGACGACACATTTCTAGGCAAGTTACTGCTCCGTCGG +TTATCTGGAATAGAGAACATTTGGAACTTGTCGATTTTCAGAAACATTTT +ACTGTACTTTTTTATGGGCAAAACATTGTTTTTTTTAATTAAACAAAACT +ACTGATAATTGTAAAAAGATCAATTTTTTAGTGTTTGAAGATCATTTTTG +AGTTCTCTAGCTACAAAATAAACAATTTTAGAGGAGTTGCAAAATTGTGA +ATTTTAAAAATAAATTGCACAATTTTGCCACTTTTTAATGGTTTTTGATG +GATTAAACCTAGATTTTCTGAATTCAGCATACATGAATTACCGCTTTTTG +ACAAAATTAGACAACTTTTTATTTTTGTCCAATTTTTTTCAGCCATCTAA +TGACTGTCCTTTTTTTTGGGCAAAAAAATAAATTTCCTAAAAGCGTTCGA +AACTACTATATTTTGAAATATTTTGAAATAGGACATTTTTTTAGGGCTCG +GAGATCAATTTTAAGTTCTCTAGCTACAAAATGCGGAAAAAAATGTAAAA +AAGTTTGGTACTTGTGTATTATACCCCCGCCATTTTAAAAATTAATAAAA +TTTCCATCAATTTATTTATTTAAATTAAACGTGATACCATTTTTCCTTGT +TAGGCTTAGGAATGGTTTTTTCCTAAGCCTGAAATTCCACACGTTTTTAT +TTAATGAGTTAAAAAATTAACTTTTAAAATGGCGGGGGTGTAATACACAA +GTACCAAAAGTTTCTAGGCCCCATTTGCTGGGCCACAATTTATAGGCTAC +AGTTTCTAGGACACATTTTCCTGGGAACATTTTCTAGGCCACATTTTTTA +GGCCACATTTTCTTAGCCAAAAATGTACTCACAAACTTAGCAACGTGGCA +ACAATTTCAAAAAAAACCTCATACCTTCTTCTCGAAAATTATTTTATCTT +TCGAACACATTGAGATATTTCCAGAAACGTCGCCGAGAATAAATTGGGTC +GATGAGTAGAAAACTGCAGAAATTGCACAAACCGGTAGAGGAATCGAGAA +GCTCTGAAATTATTCTTCATTAATTTTTTCATGCAATTTTAATCTCGGAC +CAATCAGCGTTTTGCCACGTCTTTTTTTTTTCGAACCAATCAGAGGAGTG +GGCGTGGCTAGATGCTGATTGGTCAGTTTCAAATTTTTTACAAAATATGA +CCTACCGTAGAAGAAGAGCACAAAAGTGCTCTCGCCTGATGGGAACAGAA +AGTTTCATGAGAGATACCGCCGAACAGAATTAACGTTTTTCGTGAAGAGC +TTGAAATCATTAGAATGATATTTTCATTTCGGGTCTGAAATAATTCAATT +TTAAAGGTACACGCCACCACCGTATCCTACTTCCACATGGTACTTCTGCA +CAGTTTCCAGCGCAACTTTATCGAATTTGTGAAATTCCAAAAGCCTGTCG +TAGTTCACCTTAGAATCGTCACGCACGAAATCGTAAAGGAGGTTCAGAAC +CTAAAAGTTTGAAAAATATGTCCTAGGAAATCAAACTGTGAATTTCTAGG +CCACATGATGGAAATTCGTATGAAAATTGCGACGAGCCCTAACATGTGGC +CTATTAATTGTGGCCTAGAATCTGCTGCCTACAAGTTGTGGCCTAGAAAA +AATGTTTCCTAGAAATTGTGACCATGGCCTAGAAATTTTGGCCTAAAACA +TCCGACATAGAAATTGTATGGCCTAGAAAGTGTGGGGGCAAAAGTTTTTA +ATTTTCAATTCGGTTTTTTTTTTCACAAAATGGAGAATTTTTTGATTTTT +ATGTCTGAAATTGAATGGGAAACGTGGAAATATTGCTAATAACCAACCTC +TTTGCTAATTGTAATATCCTTTTTCACATTCTCGCCGACACCATTATCCA +CAGAATCCGTCTGAACTTCTTTATTTTCTTGAAAATTTGCCACGCATTCC +ACGTCTTTTTTATTTGTCTCTATCGTCTGCGTCTCCGACGTCTTATACAC +TATTTCTCCCTGAAGGCGGATAGGTTTTCTCCACGTGAACTGGAATAGTG +TGACGTCTTCCATTATTAGCTGAAAATTTGAGTTAAAACTGCTCTATCAC +ACTAAACACGACGACACTCGTGGCCGCGGAAATTAGAAAACTCGGCCACG +TAACTTGGTTAAATTAATGAAAATATTATAAAAAACTTTCGAAAATTTGA +AACATTTTAACTTTTTTTAAAAAAAAACACATGCAAATGTTCCTAAACTG +GCTAAATAAACAACGCACATCCCCGGCGGAGCTCTGGTTTTCCATGGCAA +CCGAGAATGCGTGCGGGCCAACGGGGAGAATGTGGAGTACGTAGAGACGC +AGACAGTTGTATAAAAGGGGCGGCAACTTGAAAAAATAAATTTCTAGAGA +TTAATCCGTGCAAAGTTGTTTTTAATTACCGATGACCGAGTATGTGATTT +TTCTAGGCCACGGAACCAAATTACGGCGGAGTTCCGTTGAAAATATCGCT +TAATTGTTTTGTTTTTTCTACCAAATTAACTGACTGAAAATCCAGTTTTT +TTTTTCTGAAATTAGGTTCTTTCAAAAATCACCTGAGTGTTCCTTGATTT +GTTTTCGTAACTTTTTTCTCTCCAACTATTACACTACGGGTGTTTTGACA +ACACAATGGAAAACATGTCTGTTCAGTTTAAAGACTGACAAGAGTCTCGT +AGTCTCTCGCGGACTAGCTTACGGCCCTTGTGGTCTAGAATATTGAAAAA +CTTAGTTTCAGTATTGTGGCCGCGAAATTTGAAAACTCGGCCATCGATTT +TTTTTCCCACACCATGGGGCAATATTCACTAGACCATTCATTGTAACAAA +TATTTCAAAACTAAGAATTAAAAAAACTCCTACGCAATTTCCCCAGTCAC +TTGGCGGCTCTCACGCTCCCTATTTCAGATGTTAACCTCATTTGAATAAA +TTGCTTCTCCCATGTGTTTTTGGATGGGATACTCCATCTTTTTCAACCAA +TTTTTTCTCCTTACTTTTGTTTTTAACGGCTTTTTTTCATATTTCTGATT +GAGAATAGGTCAAGTGATGACGTAATAGAGCGCGTGGAAGAGGAGTGACG +TCACACGTGGCCTAGGAATCTCTGCGACCACCACATGAAAAACGTTTTAT +TTTCTAGGCATCCCTACCTACCCGTGTTTTGTCTCTATTTTGACAATTTT +TTGCAAGTAAATTCCCGGCTGAAACAAGGTCACCGCAACACAAAATAGGT +GAAGGGATGATCTCTTTTTTTCCAGAGTCAGTCAACATACATAAATTATG +TGTGTCTCTTCCATTTTCCTGTCGTCAATTTGTTCACTATTCGCTTCACT +AATTCCTGCTTTGCATTTTAATGTCCGTGCCCTCTCACTGGAACTGACAT +TTCACACAATGTTTTTTTCGGTGGAAAAAAGTTTTCTAGATTTTGATATT +TGCTGGAAATTTGGAAAATTTAGCGACTTGACCGTGCAAAAATTTTGGTG +GCCGAGTTTTCTCTTTGCGCGGCCACGTTGTAATAGTTGCCAGGTGTCGC +AAGTTTTTAAAATGACCGAGTTTTCTCTATTCACGACCAGATCTCTCATT +ATAGCCGACTTCCGACTTGCGTAAAAGTGCGACGTGGCCGAGAAAAATTT +CAGTGGCCGAGTTTTCACGCGAAATCACATTTTTTTAGTTTTTTGGTACG +TGGCCTAGTTTTTTAAAACCATTGTTTATCTCCACCCAATCTAAAAAAAT +TTCTGCGGATTTTTAAACCATGGCCGTAAAAAAAAGCCACTCTCATATAT +TTTTTCGACACCTTTCGGTTTTAGAAATATATTTTTAAAAATAAAATAAA +TGGCTTTGAAATCCAAATAGAAATAATTTTCCAAAAAAAGTGGAAAATTT +TCTAGGCCACTTGAAATTTTTTCCGAGATCTTTTTTGGGAAAGGAATTTG +TGGCCTAAAAAACAAAAACTCGGCCACTATTTTTTGACCATTTTTTCCAT +GTGACGTCACTTGTGACTTACAATTCCTTTTCTCAATTTCTTATGAGAAA +TCGCTTTTTTTAAGACTTTTTGTGATTTTGTTGCATTTTCTCCCAGTCGG +AGATTACGCCACGTGGAAATAGTAAACTCGGCCACACTCTTATAATTTTT +TGGCGTCTTTTGGGAAAAGTAACAAGTTCAAACAATGTAAATTACATAGC +CTAGACTTAGCTGACCAAGGCTTGTTTGAAATATTTTTGTGGCCTAGAAA +AATAAATATTCGGCCATTACTTTTTCTTCTCATTTTTGTCAGAAGACGTC +ACTGAAAACCTAGAAATCTCTCTTCCAGGGCTGCAAATGAGTATATCCTC +CATACCTTCGTCACCGTCAATATCGGGATCTTCCACGTCATCGACCGCGC +CGAACATTTCATTTTGCTATACATGGACCACTAAGGTAAGCGGCCTAGAA +AAATAGAAAGTTCGGCCAGCTCTTAAAAAATCGATTAATGATAATTTTCA +GTTAAAAACGCGAAAAACTGCGGACGGCGAGGCGACGATTTTATCGATTT +CTCCGAAATTCGCGACAGTCCACCAACTTATTTCGTTTCAATGGAATATT +CGAATTCATGCCACTTCTGAAATGGTAAGGCTTGTTTTTTTTTGAGGTAG +GCAGGCACGAAAGCGTCTGCTTGCTTTTCGAAAACACGTGGCCGCGGACT +GAAAAACTCGGCCACCAAAAATCTGAAACTGTGAGTCGCCCTGACAGAAT +TTTTTATTTTCTCGGCCAAACAGCAAAAGCCGACAAGTGAAGTTAAAAAG +GGAGGAGCATTTTTTTAAATAAAAAACTAGACTCCTAATGACCTCAAAAA +TATCATATTTTTAAATGTAAGAGTCGGCCACGTCCGCGGTCGATTTACAC +AGTGTCGCGGCTCGGTTTTCATTAATTGAGCACTGAGAAGTTTCACTTCT +CCAATTTCAATTTTCAGAACGAAGAAGACGAAGAAGTGGACTACGTGGCA +GTTGACCTTTACCTGGTAGATGGTCCTGTAAATGAGGTGAACGTTATGGC +CGAGGTGGGGGCTCTAGAGAAAACATCCACAGCAACGTTGGGAAGCCTTC +CCGCAGGTCAGAAAGAAGCAAAGACTATAAAAATGCAAAAGGGCTCTGGT +TGTGAGATAACGGATGCAGATCGAGAATGTGTGTCGAAGTATTTGAAAGA +GAACGTGGAGAATATCATCAAAATCTCCATAATTATAAATATGGAGACAC +GACTTTTCGAACCATCAACCTATTTGGATGCAATATCTCCAACTCCTCGA +GCATCATTTCTAACGGCAAATTACAATGCGAGAGTTAACAGTAAGGTATG +GAAAAGGCGATCACGGAAAAGGAATGGAAGAATCGAGCGAAGAGTGTTAA +GTGATAAAGAGAAGACGAAGTATGAGAGTAAAGTACAAATGATATTGGAT +GAGGAACGGGAGAAGCTGTGTGATAAACGAGAGATGTTGAAGGAGGATGA +TGGTGGATCGAGAAGAGCTTCGTTGATTTCTCAGTTCAGGGAGAATCAAC +ATGAATCTGTGTTGGATGATCATATGTTCAAGAGGGTAAGGTTTTTATTT +TTAATGCCTAAAACTTTGAGATTGAGGCAGTTCAATAGGCTATATACATA +TAAGTGTGGACCCAACAAGTTTGTTACATGAAGTATTTTTTCCAGATCCT +CGTTAGCTGCTGTGAATCTTGCGAGCAACGTCGTCTATCGTTCATGTGTG +ACAGTCGAACCGAGGATGATTCTGAAGGGGAAGATTGTGAAGACAATGAA +GAAGATGATGGAGAAGGTGGCTCCGATGATGAGGAAGACGATGGAGAGGA +GCCTCATTTTGAATGTGATAAGAGTGATAAGGAGCATGTCCACGATGTAG +GTCTCCTTTAAAATATCGTCCATAAAAGCTTAATTTTTTAGATGCTAGCA +AATCTATACTTCAACAAAGTAGTCCTTCCCGAAATGGAATATGTCGAGGA +TTTTGTGGATTTCCTGATTGATGCGGAGCTCAATGACTTGCCAGTTCTCA +AAAGAGCTTGTGAGAGGTATTTGTGCAGTGAGCTGAATTCGGTAGGCTTC +TGTTCAAAAAAATATAAAAATCTAATCGAAATATTTTCTAGAAAAAAGAC +ATTGGAACTTGTCTCCTGTTGGATTTGCTTTTCAACTCGATTGTATTCAA +CTTGCCTGTTATGAAGTCGATGACCTTGACGGAGTTGGCGAATCGAACGC +ACGAGTTTGTGGATGCTGACACACTTTTGGATCAGGAAGAGTTTAAGTGA +GTAGGGTGTGCGGCAAATTTGCCGAATTTGCCGAGCACGGCAAATTTCAA +AAAAGTAGATTTGCCGAATTAGCCGAGCTCGGCAAATTTCGAAAAACTTA +TTCATAAACCAGCAGTGTGTAAAGAATTCAGTAGTTTTGGTGCTCCAAAA +ACATTAAAAAATATCAAATTTTTTCGAGTTTGTCAAGCACGGCAAATTTG +CCGAATTTGTCGTGTTCGGCAAATATTGGAAAAATAGATTTGCCGAATTT +GCCGAGTTCGGCAAATTTTGAGATTTGCCGCACACCCCTGGTGTGCACCG +TTAAAAATTCTTTTTTTCCAAAAATCTAAAACTTGAGGTTAATAATGTGA +CCGAAAAACTGAAAAAAAAAAGAATTTGCCGCTGCAAAACCATAATCCGC +CAAAAGTTTTCTTTGTTTTTTTTTCGAATTGCAGGGTTTCCGAATCTGTC +AAAATTGGAAACACGACAGTTTGCCGAAAAAATTTAATTTTTGAGTGAAC +TGTTGATGCGAAATTCATTAAATACGATTTCAAAAAGCTCGGTCACGTAT +TTGTAATTTTAGAGTGGGATTAGCTATTTAAAAATTACATTTGTAATTTC +CAGAAACCTGGATAAAAGAATGCGAACGCTTGCCGATCGGAATCTCGTGG +AGCTCATCGAGCAATGTGTTACGTTTCGTGACCAAAAAGCAAGAGTTCGC +GTTTTGCCGACCGCCGAATCATTTGATATTTCGTTCGACTTAACTAATCA +ATAATATTATCGTGTTACTTTTTTCCTCTGTTTTCTTTCTCATTTTTAAA +AATGAATGCTTTTTTCTTTTTTTTTACCCGATTTTCCACACGACTAACTC +CAAAATCAGCCGCGCCTTTTTGTCTTTTATCCCTGCTTTTCCACACATTT +ATCAAATAAAGAGTGCAACGAAGTGCAAAATGGGAAGTAGTAGTGCTGCA +ATCTCATTTAGAGTACACTTTTGGAGCTCTTTTCTCCAGATATATTATAT +GCTGTAGATGGAAACTTTTCCAGTTTATATATAATATTTTTCATTTTCCA +TATTGCCCTTCACTGCTCATCATCCAATGGGGTGCATCTAATTACGGCAA +AGCTTCGCGGATGGGGCGAGTAATGAGCAAAAGAGCACAAGGATGGGGCT +CTTTTGTTCCTCATTTTCATTGCTTTTTGATTTCATTTCCTTTTCAACAT +GTTTCCATTTTCGAAATTAATCGGCTTTTCTGACCCAGGACTCACGGGAG +ATGAAAATTAATCTTTAAGAATTGTGCTTTGAAAAACAATATCATACACT +TTTCAAACTTCATTTCTCCGTTGTTCCCAGTAAATTCCAAGCTGTCATCC +ATCAACTCTCTGATAAAAAATAATCATTTGGTCCGTCCGTCGCGAAAATG +AAGTGAAAAAAGTTAATCCCGGCATGTTGAAATACACATTTCGTCGCGTG +GAGTATAGTTATGCTTCGATTTCTCAAGAGGATTCTTCTTTCCCCCTTTT +CATATTTTTTCGGGCAAAGAAGAAATCTCTGTCACCCCCCGACTAAAAAA +CGCTAAAAATTCAGCGTTCATTGTTCGGTTTTCCGTTTCAAAAAGAAAAA +AGTGTGTCAAAAACTCAAAAAGTCACCGCCTAAAGTTAGTTAGCACCTTT +TTCCATTGTGAAGATTTTCTTTCCTTCAATACAACTACTACAGTTTGTTT +CCTGTGTGTCGTCCTATTGTTGTGGGTGTAATTGTTCGATAGAGCGCGCT +TTACAAAATCTCTCGAATTAATTGAAAGTAGTGTGTTGTAGAGACCTTGA +CTCCTTTGTCAACACTGTAATTAGGAAGGAGTACACCGCCGGGCGGGTGA +GAACAGTTATTATAACGATAGTGGTTTGTTATTGTTTGTTATTAATAGGT +TAGTTGTCTACTTTAAACGTTTTTTGTTTGAAAAATTTCTGTTAATTAAA +AAATACATAATTTATAAAAATGATGAGTTTTTTTTTCAAATTTCTCAAAA +ACCGAACCCATGGGGTTTTTTGAGAAAAAATAAGAAAATTTTTCTAGTTA +TTCAAAAAATCTATACATTTTAATATCTGTAAATTGTAAATTTGGAAGAC +AAAATTTTGACAATGCGTATTGAATTTGAGTTTATTTAACTTAAAGAAGA +GAAATAGACAAATAAATAATTATATATATTGCGCAACATATTTGAATAAT +ACATTTATTTTTCGTAATATTTATTTTGAAAAATGATTGAAAATAAAACT +CGAAGAAAACTATATTTAAAAATGTCGGTGCTTTTTTTACATTTTTTAAA +CGAAAAAAAATGCGAAAAAAACCAATTTTCCGAGTTTTTTCTTCAAAATA +TTCGTCCCTGTTCATGAAAAATGTTCTCACTTATGTAAGTAGTTGTCACG +CAATGCAGTTGTTGACCAAAAATTATTTTCCGAGTAAACCCTATAATTTC +CAAATTCTCTTCTTCTGAAATTTTGAACTTTCCATCGGGAAAATGTCATT +TCAACTCGAATTCACACTAATTATACATCTGTATAATTATTTAGATTCGT +ACTTTTTCCTCCTTTTGAAAAAGTGCACAGACACCGCCGTTATCTTTACA +ACCGTCTGGCAGGACCGGTGTTGTAGGCTTTAAATAAATATTTTTCCATA +AATTTCTTAATTTTTAGCTGAAACGATTTTCCAACAAAAAAAAACGCACA +TTTAAAATGGTTACCGTATTTCTTCTATCAATATGGCTGCAATACTATTT +TTCGATGGTCTTCCCGCTTGCAATACTAATAGGGAGTGCAAGACTATTAG +GGAGTGCAATACTAATTTTCAGAACATTTTTCTGACTGTGAGCTTACTAT +TTTTTTTTCTGAAAAAACTCGAACCTTGTGTGAAAATTCAGAAAATTTGA +TTGTAATTGCAACAAAAAGGTGTAATTACTTCAATTTCATAGAAATTTTT +CCAAAAATTGTTGCACAGTAGGCAAAAAATGTTGTTAAAATCTCAAAATT +AGTGAGGTGATTTTGTACCAAAAAAAAAGTAGACGCAAGACTATTAGGGA +GTGCAACACTAATTGGGAGTGCAATACTAATTTTCGGAGGGTGTTCAAGG +AGCAATACTAATAGGGAGTGCAAGTCTAATAGGGAGGTCATATTAATAGA +AGAAATACGGTAAATTTTATATTTTTCGGTGCATTTTCATTTTAAAAACA +ATTTGTTTGAAAATAATTATTTTTAAAAATCGTTTTCTTCAAATTTTTTG +TAATTATAAGAAACCAAAAAACCTTTATTTAATTTTCAACAAGTGTATTT +TCTAATTAAAACAATTATGAAAATTCACAATAAAAGTTCAGGACTGAATC +CAAAAAAACTTTTATTTCAAAAACGAAACACCTTGTTTGCCAAAAACCTG +GAAAAGCCTGGAAACCTGGAAAATCGAATAACATCAAATTTTGCAAATTT +TAAGCGTTTTCTCGAAAAAGTTGACCTGAAAAAATAGGATTTTTCAGTTT +ATTTTATAAAAAAGCGAAAAAAAGCAAATTTTTTGAGAAAAAAATTGCCT +AAATTTTCGAAAAATCATTTTCAAAACTATTCACGATTAAAATTCGTTTA +TCCATTTCTCCTTCAATTCTTCCAGATTCGAATGAAAACTTGCTCAGAAA +AAATGCTAAATTTGCTCTTTTTCGTATCCACTACTACTGCTACTACTAGT +AGAAGTTCTTCATTCGGTGGCCGGACTACTTTGAATCAAATCACATTTGT +CGGGAAGAAGGAGGTCGTGCCTTTGCACTTCTGGTCACTCCAGAAATTGA +AGAAATTGAGCAGCTCGAGTTTTGGAGTATTCCAGGCAACTCGGTCGTTT +TTGAAAACCTATTCTATGAAAACTGCAAACTATGTGGCTTCATCTGGTCT +GGCTGGAATTTTTTGTTTCAAATTTTGACCCAGTACCTTGAGAATCAACC +AGTTTTCCACGTATGCTAAAATCCGAAAAAGTGACTCACACGAGAAAGTT +TCAATTTCCGTGATGACGTTCGCCTGGCTCTTCAGCTCATTCTTTTGTCT +CCAGAGCTCTGGGGAGCTGCAAATGAGTTGAGAGCAAGCACATTGCGTGA +GCAAGATAGCTCCAAAAGATATGAAGAGAGCAGGCGGGAGATGAAATTGG +ACGATGAAAAGTCGCCAGAAGCATAATTTTGGTGCGGCGACACCCGAATA +ATGAGACATTTACGACTTTTTGGAACATCTTCTACGGCCAGAATGTTTCG +TAACATTTTGGTAATTTGAGTTGTAGTTTTGAGGGGCTTTTTTCGATTTT +TAAATTTGTATTGACTCTTATTCGCAAAAAAAGAGAACTGCTATAGCACG +TGTAGTCAAAATGTCTTTTTGATCTTCAAAAAATGCGGGAGTTAAGACGC +AGACATCTCATCTGATTCGCATGGCTAAGAGCGTGCTGACGTCACAATTT +TCTGGAAAAATATTCCCGCATTTTTTGTAGATCAGGCTATGATGTGTGTG +TTCAATGAGACAGCCTGACACGACGTGATGTAGTTCACATTTTTCGGCAG +TTTTTTTCCTGAAAAATGTGGATTTTCGTTTTTTCTTAAGTTGTCAAATT +ATCGAAAGCTACTAAGCTTGAGTAACTTAGGAAAAGTAGGATTTTAAATT +GTTTTCACGGGCCTCGCAACGAAAGATCTCACTACTATCACCAGAAATCC +AAAAAAACGAAAATATTTGTCGTGCCGAGCCCAGGCTCCGTATTTTTGAA +GCGAAATTCCTAAACTCCCTAACCGCTGAAAATTTCTGAGTTGATTTTCC +ATCACCTTCTATATACAGTCTTTCGACCCGAAAACGATTTGAATTCGGCT +TTCTCCTCAAATCCTCTGTATTGCATCCTCTTTCTTAGTTGATTTATTTG +TAGCGGATTCTTCCCCTTCCCATCCGTGGCGTTATTGTTCGGTTACGATA +CGCTTCTTGTGAAGGTTATATGCAAACGACTACTTGCCATTCGATTCTTT +CTCCAAAAACGGGTTATTCCATTTCCTTCAACTAAGGAGCTGTTTTTTTC +TTGGTTTTTTGTAGAAAACCTACATTCAAAGTCGAAGTAGTGAAAGTCAA +AAATTACCAAATTTCGCAATTTAATTTTTAATAAAATGTCGCCCGAATTA +ACGATAAGTTAATAAGAACAAAATTCAGTTAGTCCGAGAGTCGTGATTTG +CCGATTTAGAACAGCATTTAGCTGAAAAAAACGATTTTTTTCCAAAGTTT +GAACTGCCACTACATTTTTCTCAAGTATTGAGAGTTTTGAATTTCCATCA +TTTAGTTGTAACCACACTTTTCTTCCGATTCCCATAGCAAGCGAAAGTTG +TCTTGTTTCCGAATATCTGACCTAACTTGGTTTTTTTACGACTGATGCCG +AATTTTGAAAAGTTTATTAGAAACTTTCCACGCTCTCCCCTTTCCAACCT +CGCAAACCCTTTTGTCTGTAGTTGGGATCTGTTGCTTTTTTGGGCAATTT +TTTGCCAGCTTGATCTACATATCATTGCTTGATCTACATATCTTGAGCAA +AATTCCAAAAAGTACGTTTTCTTGTAGATTAATTTGTGGGTTTTTTTTGA +GAGTTTTGAGCTAAAACTTGCATGGCATATTTTTTTCACTGTTTTAAATC +ATTTACAAATTATTTTTTCCTCTTTTTAGAAAAAAAAAATGTTTGTTAAA +ATTTTGGAAAAATTTCAAAAAGGTGTTTTATCCACTTCCAAAACGTCATA +ACTTTGCTGAAACTGGACCGGGGCAGCTAAATTTTTCGGAGTGATCATTA +TTTTCACTCTTTTATCGAAAAATTACTATGGCATGCCAAGCCCGGGGACC +CATTTTTTCACTTCCCTTGTAAGCCGAAGCCTTAGTCTAAGTCTAAGCCT +ACGACTGAGCATAAGCCTCAGCCTAAGCCTAAGCGTAAGCCTCAGCCTAA +GCCGAAGCCTAAGAATAACGGGAAACTTTTTTTGTTGCTTTTTTTTGTTT +TTTTTCAAATGCCGAAAAATAATTGCGGCATTTGAATTATGACTTTGTTG +TTCCTAGAGATTCTGGTTTTCAAAATAGGCAAAAATGCCATGAACCTTAA +CGATGTTCTTTCTCCCCGCCCTTTGAACACTCTGAAGTTTCCCGCCATGT +CAACCTTTTTTGATCGTTCGGCACGATAACGTTCTGAGTGCCGCGGTGCC +CGTTAATTTCCATCGAATCGTTAGGTTTTCTCCTTCGATTCCTAACGATC +AAGCCATAATTTATCCGCAAAATGGGATTTTCTCCCTTTTGTGATGATGA +TGATGATGGCCTCCCTCTTCTCTGCGATGACAGTCGAGTGATGAATGTCT +TCCTTCACACTTGTCCGTTTATCATTTATCACTCTGTGCTGAAAACCGGT +CTCTCTCTTCCCCTGACCTCTTCGGCTTTGTGAAACAGTGAAAGAGAAAC +GGAAAACAGGCGGTGTCAGATGGTTGACACGTTGATGTCGTAATCCATTT +AGTATTAATGCTACTATGTACGCCATTTGCTATATATGCCCATATTTTCA +ATGGCTTTGAGCACAAGCTTTCAGAATTGGCAATCAATTTCTAAAATTTT +AAAATTTTGAAAACCAATATATGGGTGGAGCCTATTTCTTAACTGTTCCG +TAGTTACCGAAAAAGTCGGAAAGCGCCGATTATCTAATACTTTCGAATTC +GGCAAAACTGAAATTTCTTCAGATTTTTATGATTTTGAGAGAAAAAATTA +TATTTCTTTGCCAAAAAACATGTATTACTTAAAATTTGTTTGTTTTATTA +TTTGAGCTCAATAACTATCAAATTGACAAACAATTCATTGGCAAAAATGC +CGAATATCGTAAATTTGAAAAAATCGGCAATTCCCGAATTGCTGCACACA +TCTTGGTTTTTTGAGCTAATTAATTGAATTTTTAAGAACTTTTATTTTGG +TAATCTAAATTTTAGTTACTGAATTCATTGCGAAAAAAATTTCTTCAGAA +TAGGGCTTCCATGTAGGCGTCAAAAAGCTTGCCAAACCTTAAGACGACCT +CCGCCTGCCTACCTCAATCTATGTGCTGAAACATATGCGAACTTTTTTTG +CAATTCTTGATTTGGTTTTCATCAAATTGATAGAAATGAGAAAATTTAAA +ATTGAAAATTTACGCACAAGTACAAAAAAGGATTCAGGCAGGCGTCAGGC +CGTGAAACCCCGCCTGCTTACCATGGAAGCCCTACTGCAGAAAATGAGAA +ATCTGATGTTCAAAAAAAAAAAGAAACCAGCCGTGTTTTTCCTTGAAATT +CGAAAAGTTCCCCGATTTTCCCCTCATTTCCGGACCGTTTGTTCCCATGG +TGGACCGGTATTTTCACCACTCCGTCAAAGGCGATTATCGGGTCTGTCTG +TCGTCGACGACCCATCACACCAAATCGGTTGAATTGTCGCACCCCTTTTT +TAATCGGCAATATATTTACTTTTTATTTGTAACTAAGTAGTAAACAGTAA +TAGTTTTTGCAAGAATATGCATAACACCTTATTTCACTTGGTAAAGTAAT +TGAACTGTTGTAATTGAGCTGAACATGATTCACCTACGAAAAAATGCCTG +TGACCTAGGGCTTGCATGTATGCGTTAAAATGGCTGCCTGCCTGACCTGA +AGGCAGCCTCCGCCTGCCTTTTGCCGGTTTATGCTAAAAACACGGTTTAT +GCTACGTGAAATTATTTTTTCATTTTTAATTTGATTTTCAACTTTTGAAA +TTTGAAAATTCACGTCAAAATGCAGAAAAGAAGGTGAGGCAGGCAGGTTT +CAGGCAGGCGTCAGGCCCTGAATCGGCGCCTGCCTATCATGAAAACCCTA +CTCTGAACTCGATTTCGCCCTCCAAACATCAATTTCCGTCATTCTCCTTC +CGTCCTTTTTACCCACTTTTTTAATGAATTTGAAATGAGTAGTCGAGGGA +AATTTAGTGAACCTACTAGAAGTCGCCACGGTTTTCAGCAGCAAATTTTT +TAATTTCGTAGAAATATGTGCTTCTGTGTTAAAATTAATAATAGCTAAAC +TATTGGATAATGTACTTTAAGACGTGCAATGTCACTCCATATTTTATAAA +ATGTTGAAAATTTTGGAAGGGATCGAGGAAGTTTTGATACTTTTTAGAAA +TCGAAAATTTTCAATTTCCGATTCCCTTCAACATTATATACCTCAACAGT +TTAATAAGATACAAAAAATCTTCAGAGAGTCATCTGTTCGCACACAGTTT +TACCCCTATCAAATTACAGATGTGTTGCCTTGCACATCTGTGAGAACTTC +ACACTATTCTGCTACAACAGATTTTCGGAACAGAAGGTGTGATGTTTCTA +CCTGACTATGAAGATTCACGTGGGCGGCAATCCAAATTTTTTGAAATTTG +GAGATTTTCGAGTTATCCATAAAAGATTCCGTTAAAGAGAGATCACAATT +TTTTTTGTAGATTGACAAGAAAATTACCCCAACAATACTCAAAACAATTG +TAATTACAATTGAATTATTACTTTTCAATTCTTAATTTTTTAAGTGCTGA +AACTTTTCTATTGACGTTAACCCCTGCAAAAATGCAAAATTGATCAACAT +CTAGTAAATCTACTAACAAGGGAAGTCTTTGAGGGGGTCCGTAGATTTGG +GGTTTTCATGCTAAAATTCCTACAGAAGAGTGTTAGTTATGATCTCTCCA +AACATTTTTGCGCATTTTTAAAGTGATTTTATTCTTATTCGGGAACCTAG +AATCATTGTCCGCACTTTTTGGAAATTTTTATTTTTTTCATTTTTGCTCA +AAATTTCTTGATCAACTCCAAGCAAAAAAATCAAAGTTTTTCAACAAACA +TTTTGTTAGTTGATCATTTTTCAAAATAATTTATCTCAACGAAGTTATGC +AACTTCAAAGTTGGTTAAATATTTTGCACAAAGTTCGTGAGATGTAGATC +ATTTCGACGGTTTACTTGCGAATAGAGAGTTAAAACTTGTGTAATGTACG +TTTCATACATTTCTGAACAATAAAATAGCAATTTCATACATTTTTACAAA +AATAAAAAATTTCCTATTTTTGCTTGGAGTTGATCAAGAAATTTTGAGAA +AAAAATGAAAAAAATAAAAATTTCCAAAAAGTGCGGACAATGATTCTAGG +TTCCCGAATAAGAATAAAATCACTTTAAAAATGCGCAAAAATGTTTGAAT +GAGTTGTTTAAAACTTTATTCAACTTACAAAAATATTTCAAAAATAGAAG +GAATCGAACCAAACCTTAAATATTATCAGACGCGCGCACTCCCAACTCGG +CCACCGAGGACAATTTTCAACTCAATGTGGTGGGTGTCACATTTTCGGTG +GTCACGCAAGCTGAGATTTGCGTGGACTGCATGGTAAGACAGTGGATTTC +AATGGTGTTTTTAACTTTCAAAACGTCATAACTTTGCTGAAACTTGACCG +GGGCAGCTAAATTTTTTGGAGAGATCATAACTAACACTCTTCTGTAGGAA +TTTTAGCATGAGAACCCCAAATTTACGGACCCCCTCAAAGACTTCCCTTG +TAAGTCAAACAAAAATTCTGTATTTTTCAGAGTACTATACATAGTATATA +TTTCTGAAATTCTCTCAACAAAATCCTTTCCCCTTCCTCATTTTCCCACG +TAAAGTAAAGTCAAAATACATTTTAATTACCATTAATACCTAAATGAACC +AAACAGGTCGGTCTTGCCCTCAATTCTACCATTTAGTCTCACGGCTTTTG +TACTTGTTCACCCACTTCCCCCATTCTATAATCCAACCACACAACTTTTG +GCAACAAAGTGTTCAATCGAAATGGGACACTATTTGCTATTCCTATAATT +GACAGGCTGGTGGAAGGAGGAAAGCAGCACACGACGAAAGGCATAAAACA +ACTTGGCGTTGTGTTAATCCCACCCGTATTGCATTCTATATTAGGTCGAC +AAACAGTTCATTCATGTCGATTTTCGATCATTTCTCAGAGTTTTGCTTCG +AATTGTAGGTTCATGGAGTTAGCCATTCTGTCTATTTTTTCCGCTGAATT +TTAAGATGTTTAATACTTATTTGCCACCTTTTCGACGGAATGACATGTAC +CGGTCAAATCTTGGAATCGATCTAAGAGATGACAATTTTGAATGTATATA +CTCAAAATGGGCTCAAATGAACGAATTTCGTAATGAATTTTTTAAAAACT +TTTTTCAAAATTTTTTATGGTGGTTCAAAGTTTCGAAAAAATTGACCGGT +ACATGTCATTCCGTAAAAAAAAACGCGCTTCTATCTGAAACAACAATTTT +TTTGATAAAAACTTTCAACTACAAACTTGTTCTTTACAAAAAGATCAACA +ATTTATTAGTTGAGCACTTTTCTGTACAAAAAATTATCCGCGCAGATATG +ATCTACCAAAGTGAATTTGGAAAATTGGCCCGTCAATGCTTCGTTGCAGT +GCTATTTTAGGATCTTTGAGAGCTCGCCGTGAGCTTGGCTCTGGAGATTC +GCAGCTAAAAAGGAGTAACCGTTTCTTTAGGAGTAACCGTTTCAAGACAT +GGGCTATCGAATGGCATAGGTCTCATATGCAAGTCCGATGGGCACCTTCT +GACGGTTCCCTAGTCAGATAGAAGCCAAAATTTGGGCGAGGTATGCCCAT +TGTCATTCTAACTGTCGAAAAAGTGGCCTCCGCCAAGACGTGATAACTAT +TTCTCTCAATTACTCTGCACTCCCAATAAATCCTACACACCGTTTGAATT +GAGTCATTCAAGTGTCAGTTGTTCAGTTTCTAGCAGTTGATACGTGTGTG +TGTGTGGTGGTGGTCAACCAACTGTCGCCCTTTTGAACACACACACACAC +ACATACTTTTCCTGCCATATTCCTCCCCAAGAAAGAGAGAAAAATAAGTT +GCATCTTTTCTTTTCTATATCTCTATCCACTAACACACCCTGTTATTCGC +ATGTTCTCTCCATTCTCCAAACAACGCAATCAGTGTCCGCCTAAATCTAC +ATAATCGATTCAGGGGGAATTAACTGTGTAGTTTTGTAATACTTTTCCTT +AAGGTTCTTGAAATTTTATATTTATAACCGACCGATTATGCCTAATTATA +ATTATAATTTAGAGAATTTTTCAATTTAACAACTATTGCGATGTTTTGAA +TTTTTGATAAAACCGGAGTATTTTTTCAAGAAATTCTGTTTAAATTAGCT +GAAAAATTTTGATTTACTAGTTTTTGGTTTGCCTCAAAAAAAATCGGTAA +AAATTTTTTGGGGCTTTTTTCTCAAAAAAAAAAAAAGAACGATTCAGGAG +ATTTTTCATAACTTCGAAACTTAGTGCAAAATCTTTTACGGGGTGTCGAT +TTTTTGATATTCGAAAAATCGGGTTATTGCTCTATTAAGAAAAATTATTT +CCTGGACATATTTTCTGAAGAATTCCTCGTCTTTTCCCATTTTTCTACAA +TTTTTCCTGATTTTTCATAAAATTGAAACTTTCGCTGTTCAGTTTTCCCT +TCAAAATGAATTTTTTCGACGACGAATGTTCAGAAAGTTAACAAATAATT +TTAAGATTTTGTCAAATTTTCACACACGTACTTTTCCACCAAAATTGACA +AAAAACCCTAAAATTTAATTTCTAAAATTTTCAAAAAATCGTGATCCATT +CTTCCTTATCATGTTATGTCTTGCAAGCGTTGCCTCAAAGTCATCAATCA +GCTAGTTGTCATCAATTCAGCGATACTTAGAGATTGAAAGAATGAGTAAT +TCATCCTTGTTTCTTCTTCATCTCCTCACTTCACTTCCAATTTTCCATCT +GTTACCAATCAATTTGGCCTGGCGATTAGTCATCTATTTGTTCGTCAAAT +TTGGTGCAAATTGGCTCGTGTCACTGATAAGTGGTTATTTTTTCTTTTTG +GTTGATAAGGTTACCTGATAAGGTCATTTCCTTTTTGCGCCTTTTTTCCA +GTAGTAATTCCTCTAATGTTCGTTTTGAAGTTACTAATCGAAGTTGTTAA +AGTATTAGATTTTTTTAAAATCAATAGGAATGTTTTTTTAATACAGTGTT +AACAAAATTTTATGTTTTAAAAAGTTAAAATAAATTTTAAAAAATCTCTG +AGTTGAATTGTTAATTTTTAAAACTATAAACAGCATTGGCATTCATAAAA +AACAAATTTCGACAAAAAATTCGTAAAAATTGCTGAAATCGCACTAAAAA +TACTCAAAACACTGAATTTTTTGCTCATAAAATCTGGAAAATCAAGTCGT +TTTACTTGATATTGCCATAGGAAATTACAAAAAAAAAGTGATTTTATTAA +AGGCTGGTCAAAATTTCATATTTGAACAACGTTTTATAAAACCGCTGTCA +GAGTAGAACAATATAGGTGTAAAATGTAGTTAAAAACTATTCTTCGATTT +TCCTACATTTTTTTTTCTGTAAATTGAAGTTTTCTCGTAGAACAAGAAAA +TTTAAATTTAAACCAAGTTTTTAAATTTTCAATTAAAAAAAACTACAATT +TTCGATTTTTAATAAAACATTTTAAATCCCAATTTTTCTTTCAAACATAT +TTTCCAATGCTGATTCTGAATCCATGAAGTCTTAACACTTCAATTTCAAC +ATTCTGTTGCAACAAGTCGTCCCATCTGACCAATAACAAGGGCTCATCAA +TCACTGACGAGGGCCCCCGGGCGCCGCCATCATTTTCCTCTCTTTCTCTC +TCTCTCTCTCTCTCTCTCTCTCTCTTTGTTTCTAAAAAGAAGGAAAATGA +GCTGCAATTTATCAAATCCACGGTCTTTTTCCCTCAAATTCTCTGCCTCT +CTAGTCTTCTCCCTCATGGTCATTGTCGCCACATTTGTGACTCACAAAAT +GGGCCGTATTATACAAAAATAATTAAAGTTCAATGCGTATGCGTGTGTGT +ATTTGTTGCTGGGTGAGGGCAAATGCACATTAGCCACCCACAACAAACTT +ACGTTTTTTTTTTTGTATTTTGCCTTTTTCTTCTTGAAGAATGGTGTCAC +ATCACATTACGACCTTTTCTTTGTTACGGAGAAAAGAAGATTGGAGCGGA +ACTGACTGAGGTGTGAATACTTTGTTGGTTTTTTTGGCTATACCTATTAG +TTACCTTATTTTTGAGAAAAAAAAATTTGAAGCATGTTATTTTTCGAGTT +GTTGGTAGGATGTTGATAATTACTGTTATCGTGATTTTCTTATTAGAAAT +TAATTTTTATTTATTTAGTAGAATTGGGGATTTTTATTCAAATGATCCAA +AATAATCTTTCGACACTGAAATCACGACCATTTTTGAGCCAATCAACGTT +TTCAAACTCCGCCTACTCTGTCTGATTGGTAGGAAAAGTGGGCGGAGCAA +ATTGCTGATTGGTTTCGAAGTTCTCGACTTAGAAATACCAGAGTTCATCA +AAACTGAAATATTGCGTTTTTAAAGGATATATTATTATTATTATTATTTT +CTCTCGATTTTTTTATTCTGTGGTTGCTCTGAATTTCAGATTATTCGAGA +TAGTTTTCGATAAAGCGACAGATTGTTCAGTTTCTGAATTTTCCATAATT +TATCCTCTAAAAGTGAAAGTCAAGGTTTCGTTCTTTGCAAAAAACTCATT +TTTTTGAGAGTTTTCGGAATTTTGGCTCGCATCACGCTCCAATAAATTAA +TTCAAAATTTCGGAAATTATTAACTTCTTCCATTTTATCAATACTGTGTT +AATCTCACTTTTCTAATTTGAAACAAAAATTGAATTTTCATCGATTTCCA +AAATACTTTACATGCTTGGCAATTGAAAATTAGTTTTGTTTTTCAAATTC +TCAGTTTCCAGCCACTGAAAACATTGCGAGCCTCCATTGGGTCCGCTCCT +TCCTTCCGAAACACATTTCCCAGTACTCTTTCCAATCTGGTCAACATTTG +AAAGGCTGTTGGGGGGTCGAAAGGCAATAAACAACCGAAAAATAGTTTAT +TCCAATGTCATCGAATCCTCCCTGGCTTCTCATATTGTTGCCAAAAATGA +TGATGGAAATTGTTTTTCGTTTGTATACACACACATCATCCTGTGCCACA +CCTTTTCCCCACTCTTTTTCCCGACGAGCTTTTTCATTCGGAAGGCGACA +CAGATAGCAATTACCGACATATGGAACCAATCGTACTCTCTCCGCTGACT +GCGACTACCTAATTAACCTTTTATTGAAAAAATGAGAGAGAGAGAGAGAG +AGGATATGAACGGAAGAAGAAAAAGAGGCAAAGCAATTGTTTACTTGTTT +TTCGAAACAATTCAAAATTTTGTTTGGGCTGTGCGCCTTTAAAGATGGAA +AAAAAACGGAAATTTTCCAGCAATTCGTTAATTTTTTTGTCGGCAAATTT +GGCAAATCGGCGAATTACCGGTTCGCCGATTTGCCAGAAATTTTCATTTT +CGGCAACTTGCCGGTTCGCCGATTTGCCAGAATTTTTCATTTTCGGCAAT +TTGCCGGTTTGCCGTTGCCGGAAGTGTTTAGAGGAATTGTTTATGAGACG +GAAGCACTGTGCCTGTTTGCCAATTAAAATTGAAATTCTGAAATTTCCAA +AAAAATGTGCACAAGCACCATTTGCCAAAAACTTTTTCAGTTGCCGGTTT +GCCGATTCGCCGGAAAATTTAAAATCCGGCAATTTGCTAATTTGCCGGAA +AAAATCGTCTACCGCCCACCCCTCCACCGAATTCGGAAATTTTGTAAAAA +ATAACTTTATTTTTGGGCCAATACGATACTACTTTTCCTAAAAAGAAGCT +GTTACAGTAATCAATGTATCATCTTTTCCATCTCGAATGGTACCTGTGTT +TACCTTAACTGTCACATAACTGTGAAGAGTACTTGAGATGACAAGTAGTC +TTATCAGAAAACCTCCCCGCTTACTGCTTCTCGGGTGTCGGGTTACCGTG +TTTGCTGAACGGTTTTTCGTAGGGATTACTGTAGAGAATTGGATGAGTAG +TTGGGATTAGGCGATTAGGGGGAAATTGGAAAACATGTCTGTGCACTCCA +TATGTTTCTAATAAGAATCCTTGGAAATTTGCATATAACTCAAGAATGGT +ACTGGTCCAGTTTCGTTTTGTTATCTTGATTCTTCGAAATGGTGCTCACT +CAACTTGATTCCATCCCCAGGACGCTAGTTATTTTCGTAATCTCCGCGTT +CGATCTCGAGCTCCTCCTCTATGGAAATGTTAATTTGTGAGGGCTATCGC +GTCCACAGATTTATAGCGTCCGTCGTGCGGTTTCGCTGGGTTCTCGCAGC +CACCCCCCCCCCCCCCCACTCATCAATCGCGTAAACTTTTTGTGAGCACG +CAGCACACAATGTGCTCAGGAGGCTTCTGTCTCTTCGGAGATCCAACATG +TGGCACCTCCTCAAAGTGTTCACTGGCCTCCTCGGCTCGGCAGTCAAATT +TATTCATCTCTTTGGAGATTGGCTCACAATTTTTTTGATTTGAATTCAGT +GACTATTTATCGATTTCTAGGGCTTCTATGTAGGTTGCCTGTGTGCCTGT +CGTCTGACGTTAAGGCGGCCTCCGCCTGCCTCTCGCCTCAATCCGTGCCT +TGTGCCAAAACATACGAATTAATTCGATTTTTATCAAATTGATAAAAATG +AGAAAATTAAAAATTTGTAAATTCAGACAGGCCTGAGGCAGGCAGATTTC +AGGCAGGCATCAGGCTCAGAAACCGCGCCTGTCTACCATGGAAGCCCTAC +TGCTATGTAACGTTTGAGATATTCGGTTCAGATAAAATAAGTTGAAGTTA +CGCGAAGAAATTCTGAATTTTGAATATTTTCCAATAGTTTCTAATAGTAT +TTAGATGTTGTATTTAGATACTGTTGCTACAAAATTTTTAGAAAATTCCG +TGGTAAAGTTCAAAAGACTACTCTTTCTCTGAATATTGGTTAATAATATG +AATCCGTTCTGCTTTTTTTCCGTATTCCAATTCTTGACGACTTGATATGA +AGCCAGCTCAAATAATAGGCCTCCCACGTAGTGTCAGGCTGTCCCAATAC +GGTTTGATCGACAAAAAATGCTGGAGTGTTATGCCCTTCAAAATGTGACG +TAAGCGCGCTCTTAACCATGCAAAATCAGTTGAGAACTCTGCGTCTCAAC +TCCCGCATTTTTTGTAGATCTACGTAGATCAAGCCGAAAGGATACACTCT +GTCACCACGTGGCCTCCTAAGGACTATTTTGCAAGGACCTAATTTTCTGA +ACCTTCACAAATTGATCTGCACCGTTTGAGATCGATTGAAAAGTTCTAAA +ATTTTCTGTCCTGTATACTTTTTTCTGTACATAAGTCCTACCGAAAGGGT +CCCCCGCGGTAATAATTACCCGTCAAAACAATGTGTACTACTAGCCGAGA +TATGAGTTGTTATTGTTGTCATAATACAACAAGATTTGGATCACCGCCCA +ATTTTCTTGTCAAAAAGTTCCGCTTATCTCGTTTTCTGCTAATTAGAGAA +TACTCTATGGGAATTGGTTGATCCACTCCATTAGTGAATGTTCCCCCAAT +AACCATGGAGCTGTTAGAACAAAGACGAAAACCCGCCAGAAGACACACCT +TCTTGAGAGCAGGTATTAGAAAAATGAATGAAAGGAATTGGGAGGGGAAC +CCGCGGTGGCCGAGACTTCCCACTTGACCCGATTTGTGCACATACGCAAT +ATCGATGAGGAGTGGTGGTCCATTCGATACAGTCTTGCACCATGTTTGTC +GAAATGCTATTTGGTTGGCTGGCAGATGTTTTTGGTCCAATTTTCTTGTC +AAATTTTGTCTTGATCTGACAGATTTTAGGATTCTTGGAATTCGACTCTT +CACCGAAAAAATATAATTTTTCGGAGTTTGTTCAATTTTTCAGTATCCTG +ATTGGAACATTTTAATGTTTTACAAAATTCGATTCTAAATTTTAAAGCAC +ATTTTGACCTAGTAGGACTTTCGGAATTTTGTAGCCTTTATAAAAAATCG +GTGGCCAAGTTTTCTATAATTTTTTTACGTTTTGAAATTGCCTTTTTATG +AATTTTAAAATGTGGAACATTTTTTGAATGACTTAGTTTTTCAAATTCCA +CGTAGTGTCAGAGTGTCCCATACCAGTTTAATCGACGTTGATCTACAAAA +ATCGCGGGAACTCTGACGCAGAGCTCGCAACTGATTTTGCAGGGTTAAGA +CTTGCTGACGGCACATTTTTTGGGAAAATTTTCCGCATTTTTTTGTAGAT +CAAACAAATTTCATATTGCCTCGATTTGTTCGCTATAGTTGTCTAGTTTT +GAAATCGTTGGAATTTCTTGAAATTCGAGTTCTTGAAACATTTAGGTTTT +CACCTAGTTTTCTCTGCGTGTTTTTTGTGTTGAAAAAACGGTTCTCAGAA +ATTTGACTGCTTTGAAAATTTCGAATTTCATCTCCAAAAAAAAGTGAACA +ATTCGTATTTTTCTAGAATTTTTGGAAATCTCTTTAAAATGAGTTTTTCT +GAAACATTTTAATCTTGAAATAGTCAGAGTTACGTCAAATTCTATTTTTT +GAGGAATTTATTTTTTGTGAGAAGAAAACAACAAATCCGCAATTTTTTTC +CGAATAATTAACCAATCCAAGATCCCCCCTCAAACCGGATGGCATTTATT +CGGATCCCGGCAGGTGTTCGAATGAGATATGTATCCATTAACACATTGTG +CATACACATAGACACATTGTCAACGTATGCCGTACACAACAAAACAACTG +CGCTCGTTCGCACCTCAATCCTTTGATGTTCTCCGCCGGGGGCTCCTGTA +AGGTCAGGAGTTTTCTAAAAATGTTGCCTTCTTCTCCGTCTTCTTCCTCT +TCATCATCGAATATTCCAGAGGGGGGCCGACACGCTTCACTTGATTTTCG +ATGGCAATTTGTTTGAAGAATTCAAGAATTCGAAGAATTTATTTGGAAAC +TCACTACTCTCTTTTTTACGTTTACATCCAACTTTTGGCACTTAGGCGCC +TCCAACTGCAACCATATGGTGCTCAATGAGCCGAGAGGGATCATCTGTGA +ATTTGGTGTTTTTTTCTCAATTGGTTGCCTATTTGATTGGAGAGAGATTA +ATTTGCATACAATTACCTCTATTTGGCTCAGGGGTGGACGGATATTGCCG +TTCGGCATTTTTTGCCGACAAGTACGGCAAATCGGCAATTCGCCGATTTG +CCGGATTGCCGGAAATCTTGATTTTCGGCAAACCGGCAAACATCAGCGTA +CTATTTTACTATTCAAAATAAATGTAGGAACATTCATAGGATGCGTACAA +TTTTGCCGATAAAATTTAAATTCTGAAGCTTCAAAAAAAATGTGCAAAAC +CACAATTTGCCGAAAATTCTAGCCGATTTCAATTCCGGCAATTTTTTGCC +GAAAAAAATTGCCGCCCACCCCTGATTTATATTCAGTCTGTTACCGATTC +TAGTGAGGGGTTTCCAGCCTTTGCATGAATAGGTGTCTGCTACATTAATT +GCGCAATCCACATTGATACAGAGCAACCTCAATTGTTGTTTTTTCTGTGG +CCCGTTCTGCTCGTTACACCTATAAAAAGGTGGTCAAACAAGTCGTAAAA +TTTGGGTCATGAGATGGTCCCTGGGTTAATTGGAGAAGTGCCGTCATTGA +GAGAGAGAGAGCCAATTACGTATGAGGTCTGCTCTGCTCTCGGGAAGACT +CTATAACCCTTCGTTTTTGGCGGGAGATATGAGATATTTTGCTGTAATTA +TCGCACTTGTTTTGGGTATTCTCTTTTTGTATGATTTACCTAAAATTTTT +GAGCAGTTGTGATTATCCTATTTTGTTTCGAGAACCTAGAAATGTTTCCT +ATCATAGTAACCGTTTAACTCTGTGAGTATAGTTTTACTTTAAGTTGCTC +CGTTTTTTATTTGACTAGCACAGCTTTTTTACATTGCTCCGGTTTTGGCC +AAAGGTTTTCTGTTTTTTTTTTGCAGTTCTGACTTATTCTGGCCTGCTTT +ACCCAGCTAAGCCTAGGCCCGGTTACAGTCCATAAGACAACATTTTTGAA +CTCAATAATTGCCGAATTGCCAAAATGCCAAATTTTCGATTGCTGCCCGT +CTGAGTAAGTCTGAAACAGTTTGTGTGAAATTGAGCCGGAAACTACTCGG +AGTGATGTGGCCACTTCCCTATTTAGTTTCTCGGTTGATTTTCACACTTC +CCGCCGAGAGCCCGAAGCATCTGCCAGCTGAACGGTTTCCGTCGTTTTTC +ATGTCTATCGCTAAAATGTGCGCGTTACACACACATAAACATCACTTCTC +TCATAAAGTGATGGATAATTCGAGTGGATTGCATCTGACACCACACTTCC +GATAATCGCTTCGTCGTCTTGTCATCATCGTCGTTTTCTTCGTCTTGTTG +TCGTCCGGTCCCCACACACACATCAAAACGGCTACTTCCGACGTGTCGGT +GGTTTGTGTGTGTGTCAAACGGCACCACCACAAGTGGTTGCCCTCGCCCG +TGTGCTAATTCGCATTTTGTCTTGTTAATCACGCAATAGTGATAACAATC +GCTTCCGGACCATTGCTAATATAATATATTGGCTACCGCGGGCATGTCTT +GGCAATAACCTTGATGTCAAGTTTTATCGTTAAAATGTGAAGCTGTATGA +TTGCGAAAAATTTGAAGTTTTCCCATTCAAATTGTAGGCATATTTGAAAA +ATTTCTGAAGATTTATATCTGTCGTAAGTGGAACGGTTTATTTGGTTTCT +TGGGTCTCGTCGCGAAAAGCTTTCACTATGGTTTGAAGCACGACTGGGCG +ACAATCGAAGTCGAAGTTCGGCAATTCGATAATTCGGCAATTATCGAGTT +CAAGATTTTCGAAAGAAAAACTCAAAAAATAATTTTGAAATCTATTTATT +AGTTCTGGACACGCGGAGTCAGAAAGTCCCATTTCGCTTTGATCTACGAA +AAATGCGGGAGTTGAGACGCAGACATCTCAACTGATTTCGCATGGTTAAG +AGTGTGCTGACGTCACAATTGTTCTGGAAAAAAATTCCCGCATTTTTTGT +AGATCAAACCGTAATGGGATAGCCTGGACGTAGAACTCGCCAAATCGTAG +ATATATGCATAATGAAAACTCTAGAGTTAACTCTGCCACCCTCATAAAGT +GAGTTAGAAACATTTCTGCTCTGAGGAACTATAGAACCCCCTTTCAAGTC +GATCGTCAGCAAATTCTAGAAAGATCTGACAGTGGCCGATTTTTTAATGT +TTCTAGGCCACGTAAAAAAGCTGATGTCTTGTTACTTTTCAATTCGAAAA +TCCCTTTTTTTAATTTTTCGGCAGCACCCGGTCCGAGCCAACATCTTCCT +AAACACTTCAAAACCCCGCCCCCTTCTGCCCTCCCGGGTGTCTCCGTGTT +GTTCAGGGTGTTGTCCACCCCCTAGACACCCAACTGACCATTCACCCGTC +TCCTCCTCCCCCTCTACAACAACCACCACCACCTGATCCATTCCATTATA +ATGATATTCCGCATACTTGTCATACAGAGAATACCCGGTTTGCTGCTGCC +AAACGGTTTTCATTTATTCCATTTCTCACTCCTTGATTGTTGTCAATTCT +TCGATTCGATGCGGCAAAACTAGCGCCAGTGGGGAAATTGCTTTAATAGT +AAACAATTTTTTTTTAAATTTCCTATATTTTTTGTATAAGATTTTCTTTT +TTAATTGCAAATCCCATGGGAAAGTCTCAAATTGCATAAAATTCCAATTT +GAATTCCCTCCAAGATTTCAATGTTCGATGGAGCGCACTTGAATTATTAT +AATTTTTATCAATGAATTTTTTTATCATCTCTGACTGATTTTTCACGATT +TTTTGTGTAGTTTTAGAGGAAATTTACTGAAAAATCCAAGTTAAATGTAA +ATTTCCGATTTTTATACAATTTTTGGACTACTTTCCCCGCCGCCACCGCT +AAAAATCCCAATTTCCTGCAAGTTTTCACCTGCTCTGACTCATTTCCGCG +AGCGCGCGCGCTCGTACTTTTTATCTTTTACTATTTATTTATCTCCTCCA +AAAAAAAATCCCGTTAATTTTTTTTCCCTTACAATTTCTCATAATTTACT +CATTTAGTTTGGCTTAAAAAATGCTAAATTAAATTTTTTTTTCATTTCCA +GATCACATGACACAACGAAAATGAGGAGAAAAATGAAGTTATTCCTATTT +TTATTATTAGTAATTAATATATGTCGGTCGGCCGCTGCTAACGGTGACGA +ATGCCCGAAATTGTGAGTTTTTCGCTTAAAAATCAGATTTTTTTCGAATT +TACTGTGAAAAAGCGGGGGTTTTGCCTGAATTTTCACTTAAAACTGCTTT +TTTTTGCTAAAATCCCGAATTTTTCAGAGAAAAATAATTCAAACTCCATT +TTTCAGCTGTAAATGTGCTCCGGATCCGGTGCAGCCGACGTCTAAACTCC +TATTATGCGACTATTCTTCGAAAAACACGACAATTACACCTATTGCGTCG +TCGAATTATGATCAGGTTGCTAATATTCGGTGAGGTTTTTTGATTTTTGA +ATGAAAAATTTGAGAAATTTTTAAAAATGGGAAAAAATGTGATTTTTAAA +TCAAGATATCGGAAAATACGAAAAAATTTCCAAGAAAATGGTGGTTTTTA +TCGAAAAAATGTTAAAAATGCATAGAAAATTTGGATTTTCGAGTTCGAAA +TTTTCTGAAAACAAAAAAAAAAGTTTTTTTTTACACTAAAACATTAAAAT +TGGATTTTTTTTTCCGAAAAACATAATTTTTCAATTTCTAACAGTAAAAA +GCTCACAAAATTCCTTGAAAATTGACAAATTTAGTATTTTTTACACGAAA +AATGCATTAAAATTGAATTTTTAAAACAATTTAAACTTAAAATAAAATTT +TCATTTATTCTACACGGTAAATGTATTAAAATAATTAAAACTTCGAAATT +TTAAATTAGAAAAAATCAAATTTCCTCCTTATTCTCAATTTTTTTTTACA +GCAAAATTTCAGTTGAATTTTCCCATAATTTTGAATTAAAAATGTGTTTT +ATTCCAAAAAAAAACTATTTTACAACAAAAAACTAGATTTTTTCCCAATT +TTCTATGAAAAATTTAATTTACCAATAACTTATTTTCTTTTTCCAGATCA +CTATTCATATCTTGTGATAATAATAATTTCCAATTTCCGGATGCCTACTT +CAAGTCGTTAACCGCGTTGCATCATCTGCGGATAGTGGTGAGTTTATTAT +ATTATCAGCTGTTCTCTACAGAACATCTGCTTTTTGCGTGTAAATTTAGA +GGTCAATTTTCGGAAAAATTGGAAAAATTGGCCTAAATCTCAATTTGAAG +TAGATTTTCACGTGTTCAAAAATGTTCAAAAAATTCAATCAAAAATTCGA +TTTTTGGAATACTTCAAAAAAATTTAATTTTCTTCGAGAAAACCGGTAAA +TTACAAAAAAAATTCGTTGGCGATTTTTTTCTGTAGTTTTCCAGAAAAAC +AAACGAAAATTTTAATTTTTAATTTTTAAATTTTCCAAAAAAAATTTTTA +AAAATTCATAAATATGTCCATTTTAATTTTAAAAATATCGGAAAATATTC +AAAAAATGAACTTTTCTATCGAAAATTTAACAAGAAAAAATTACGAAAAG +TTCATTCAAAAAATTAAAATTCTTCTATATCTGAGGAAGGCTAACAGTAA +TTTTTTCCCATTTTTTGACTCTTTGAGCAAATAACCGTATCACTAATTAC +CTTAACCATCAAAAAAGAAAGGTGTGCCTGTCTTCTATTCATCCTCCTCT +CGACACCAAATTCTTAAGAAGAGCCCCCCACTCGGATGTCTCTAATTAGG +CACAAATGTTACGTCATTTTGTCATTTGTACGGCCACAGATGACCTCCGG +TGTGCTTGGAGGACTGCGAGAGAGGAGGATTAAGGGGATTTTTATGTCCT +ACAATTGATTTTTTTAGGTCAAAAGTAGGGATTTTAAGGCCAAAAATAGA +GATTTTTTAGGTCAAAAGTAGGGATTTTAAAGCAAAAAAAAAAAATTTTC +GGCCAAAACAGTGGTTTTTAAGGCCAAAAAATTTAATTTTTCCGTTTATG +ACACCTAAAATTGGGGTGAAATTTTTTTTTCGGATAGAAATCTAAAATTG +CAATTGTTAATTATTCCAACATTTTTTTTTGCATTAAACGTTATTGTAAA +AACATTGAAAATCACTTGATTTATCCGAAAATTTCATTTATTTCAGATAA +ATATTGTTTAATAAAAAATGTGTTAAAAAACATGGTGCATAGATATATAG +ATAATTTTGTAGAATAATTGAAAATTGCAATTTTTAACTTCCTACCCGAG +TAAACAGAATTTAAATCCAATTTTAGGTGTCATAAACGGAAAAATCCCAA +TTTTTGGCCTTAAAAAATCCCAATTTTTCGGCCTAAAACTCCCTAATTTT +GGCCTAAATCACCCTATTTTTAGCCTAAAAAAGTCCCCTGTTTTTCCATT +TTCCCCAGGAACTCGTAGAAGAACATGTGTTAGGCGTGAAGAGGTTAAGC +CGATTAGCCATGTAATATTCAATACTTGAGTATAGAAGGGCCAGAAGCAG +CAGCAGCAGGGGGTGCTCCAAGAGCACCACCTCAACAGATGTATAAAGTG +GTTTTCGAGTAGATTTGTGGTTTTGCACACGGTGGAAGAAATCTGAAATT +TGAATTTTTTAAAGCCATTTTTGTGCTGAAAAATGTACAGAATAACCGAA +ATTTCACCACCCTTTAAGGTACGGGAAATCTCCGGGAAAAAGGCTCAAAA +ATTGCATAAAAATGGAGATTTTAAAGCTAAAAATAGCTATTTTAACAAGT +TTTTTTGCAGGGATGCGAGACCACACATTTCTCTGTGAAATTGTTCGAAG +ATTTGGCCGCTTTGAGAAGATTGGAACTCGATCAGGTACATTTTTCTTGG +AAAATCTAGAAAATTTTGCTGAAATTGGCTCAGAAATGTCCTAAATAGTA +GAATTTTTCATTAAAAAGCCTCTCAAAACGGCTTAAAATTAAGTAAAAAT +CGACATTTTTTCACAGATCTCCACCGCCTCAACCTCTTTCGAAATGACCG +AAGACGTCCTAATGCCGTTGGCTCGTCTCGAAAAGTTTTCCCTCACGAGA +TCACGGAATATCGAGCTTCCACAGCGACTTTTGTGCTCTCTGCCGCATTT +ACAGGTATATTTTTGGGTAATTGATAATTCGCCAAAAAGAACAGCAGCCG +AAAACTCAAATTTTTCACGAAATTTGCCGAAAAACTAGATTTGTAAAATA +AAAAGAATGCAAGAATTTTTAGCTTAAAAATCTCAATTTTGAACGATTTT +TAAAGCAATTTCAGTATGAAAAATCCAGATATTTTTTGGGTAAAAATTTG +GTGAAAACGCGTTAAAATCTGCATTTTTGAACGAAATTCGCCAAAAATCA +AGACTTTTGTAGTGCATTTTACTGTAAAAATGTATACCTATTTTCTATTT +TTATGCGTACTGCGCAATATATTTGACGCGCAAAATACCTCGCAGCGAAA +ACTACTCTTCAAATGACTACTGTAGCGCTTGTGTCGATTTACGGGATCGA +TTGATAGAATATCAAAATTAGAAATAAATGGGAAACTACTGCGAAAACAA +AAATTTATTTCAAAAATTGAGTCCGTAAATCGACACTACAGTAGCCATCT +AAAGAATTACTGTAGTTTTCGCTACGAGATATTTTGCGCGTCAAATGTGT +TGCGCAGTATGCATTCCCATCTTGTTCTCTACATTCAATTACCACCACAT +CTCACAGAGAAGGAATTAGTTGTTTATTAGTACGTGGGGGGGGGGGGGCT +TTAAAGCTTACTACTTCTTCTTTCTTTCCACTTTCTGACGTTCAACCATC +TGGTATTCCTGGCGGCGGGGCAATTGAAAATGAGAACAAAAGGACATCGA +TGGAGGGAGGAGGATTGAGAGTTTGGAAATTGTGAAGAATGCGCGCGGAA +GGAGGAGGTCAAATATCACAAGCGCCGGAAGTTGTTGTCAGCCAGAAGCA +ATAAAGGCCTAATTATGATGATGATGAAGAACCTCCCTGAAAGAGAATAG +CGAAAATGTGAAGTTTCCATCTCAAGGGAGCGATTTTTTAGTGATCATGG +AGTCTTGAAGTGTGCACATAGTCTACGTGCCCCACAAGAGCCTATGCCTG +CCTTATGCCTACTCACATGCTCACAGCCAAACTCTTTCGAAATCAGAATT +CTACATTGTAGAATCTACAACACTGAAGTTTCTGCCATAACGTTGAAAAT +AGGCACCTACGCCTGAATACGTGCCTGATCAACATGGATGCCATATAGTC +CAGGCTGTATAGTCGTAAAACAGGGATTTTTTAGGCTCATGGGTTTTTGT +CGGAAAAAATCGAACATTGAGAAAACCAGAAATTTTTCAAATTTTCGTAT +ACTATTCCACGAATCGTTTCTCCCGTTTATCGAATCTCCACGTCGCACTG +TAATTTTTCAAGTATCGTTAGTCCATTCGCCCGAGAAACTCCACAGTTAC +AAATGCTTTGCAAGCATTTTCAAGAAACCATGGTTCCTGGCATGTTTTGG +CGCATTCAATAATGCCGCTAATAATAATAATAATGCCTCCTATTATGATG +TCGCGTTGTCATCGTTTGCTGCTGCTCCGTCAGATACTTTATGGGGTTGT +TGTTTTCTCCCTCCGCATCAAACGACGTTCCTCTCTTCAAAATGATGATG +GATATACATATATCTATGTTTATAGAAGAATTGAACCCCACACTTTACAT +ATGAATAGATGGGGACCTTGTTACCTTGACTATCGGGAAGAGATTGAAGG +TTCCAAAGACGGCTGGCTGTGGCTCATTAGGCTAAATGATGCGTGATATT +ATTCGCTCTACGGCACCTCTATGATCCAGGAATAGCAGTCACTGTCAACA +AGAGTCACCTCACGGCAACAATACTCCGCTAATTACGGTTTGCGGCAAAT +CCCAGAATTTATTTGAAATTCTAACTGGGTGTTGCAGATGGGTCGAGGAA +ATATGATAGCAATAATTATTGTTACGTGGCAATTGTAATCCGTCAGATAT +CGTTTCGAGACCTGCTGACTCAAGAATGTGAAAATGGACAAATTTGGAAA +ATAGGTAGCGGAAAATTTTCGCAAGTTTTGAAAATTTCGGTCATGATACG +ATACGAACTCCTTGATTTTCACAGCCCGACAAGCCGTACGCGTACGCAAT +TTGTCTACCGTATACCTGAACGTTCAGGCTCGTCTATCTCGAAAACAGTT +GGTCCAGCCTTTTTGTGGGGCATATAAAAAAGGTCAGAACATAAATTCTA +AAATTTTTTGGACCATAGCTTGTTTCGTTATCACGCGCCCAAACCTGATC +TACACTCAAATTATCAGTAGAGCGCATTTGCATGGATGTACCACTTGCCG +GGCCGTGATTTTGAATGGAATATTAAATTCCACGTCACTCTAGTGAATCT +CCGCTTCTCAATATGCTTCATAATTCATCAAATTCAATTCATTTTCGGAT +AAGCCAGTTGTAAACAGTTGTGTGTGTGTGAGTGAGCTCATCCTTCATAA +AATGAATAGAGATAGAACACTGACACTCTCTCAAAGACAAGAGGAATTAA +TAAATATGAGAGCTCATTAGCTGCTCTTCTCGTGACTACTAATTAGGAGG +GTGGTACATGAAACAGTGTATGTGTAAAGGGATCCCCGCCGCCGCCGCCG +CCAATGTCTTTCGGTGTATGGCAATATCCGAGTGGTGTTCTCATTTTGAA +GAGAGTATTAGGATGTAACGTATCAACTGGAGAGAGATAGTTCAAAGATT +GGGGATTTGAGATATTTTAGGTGTCGAAATGGATGAAATATAAGCATAGG +GAGGAAATAAATAGAAAACGATATACTTAAATAGCAATAGTTATTTGAGT +TCTTACTGTAGTTTTCGCTAAGAGATATCGCGCGTCAAATAAAATGCTCT +ACGTACGCATTCTCATGATTTATTGTTCCCGTAATATAAACATAGCAAAC +ATTTTTAATGTTTAAATATTCCTCAATGCTATTGAAATTCAAATTAGTAC +AAAGAAAGCAATTTTTCGATTTTTTTAACGAGAAAACTAAGTTTTCATCA +AAAAATATGTAGATTTTGATGAAAATAATATGACAATTTATTTAAACCTA +TATATTTTTTTGTCCAAAACAACTTTACGAAAAAAATTTTTTTTTAAATA +AAATTATTGGATTTTTCGTCAACTTTACGATAAATTCCGAAAAATTAACA +ATAAATATAGGAGAAAAAAATCCGAAATTAACGAAATCCCCTGTTCCAGG +TTCTGAATATCTCGTCAAATGAGCTTCCATCACTGCGAAGAGAGGAATCG +TGTGTCGCTCAGCAGCTTCTGATCGTCGATTTGTCTAGAAATCGGCTCAC +CAACATCGAGTAAGGGATTTTCCGGATATTTTATAATTTTGATCTTTAAA +AATTTCAAAGTTTGTGAAAATGTGAAAATCTAAAAATGTGGAACAAATAT +TGGTTTTATCTATTTAATACCCCAAAACTTTGAGATTTTTCCGTTGAAAA +ATCGAAAATTCGAAAATTATCTCAAAAATTTCAGGCAATTCCTACGTGGC +ATCCCGGCAATCCGGCAAATTTCGGTGGCTTACAACTCGATCGCCGAGCT +CGATTTATCGCTGGCAACTCCATTTCTACAACAACTCGATGCTGAAGCCA +ATCGAATCGTCGACTTGACGTCACTTCCAGGCACTGTTGTACACGTGAAT +TTGGCTGGAAACGCGCTGAAAAGGGTGCCGGATGCGGTAGCCGAGTTGGC +GAGTCTTGTGGCGTTAAATGTGTCGAGAAATGAGATTGAAGCCGGAAATT +CGTCGGTTTTTTGTGGGTTTTCGGATTTTTTTTTGGAAATTTGAAATTCG +GAAAAAATTCAATTTTTACATACAATTTTGCGTATTTTGATCATATTTGT +TTTAAAAATCGAGAAATTTAAAAAAAATCAAATTTCGCTTATTTTCATTG +GAGAATACATGAGAAAAATATTTTTGTTTCGAAAAAGAAAAATAGCCAAA +ATTTAATGCTATTTTTTCGAAAAATTTCGATTTTAATTTTTGAAAAAGTA +TTGAATAATTTCATCAAATTTGTTTTATTTTGATGAGAAAATACGTGAAA +AATGGAAAAAAAATATGAAAATCTTTAAAACAAAAAAATAATCAGATAAT +TATGCAATTTGGCCTGAATTTTCAAAAAAAAAACTTGGATTTTCGAAAAT +TTCATCAAATTTTGTGTATTTTCATGCAAAAAAAGATAGGAATTTCCAAT +TTTTGACCTTAATTGCAAAGAAAAATTCCTAAAAAATTGTAACGTTTCAA +AATCTCGATTTTCTTCTGAAATTCTCAAAATCTTCATATTTTTCCAGCTT +CCCCAGAACTCGAAATGCTCGACGCCTCTTACAACAAATTGGACAGTCTG +CCCGTCGAATGGCTTCAAAAATGCGAAAAACGCATTGCTCACCTCCATTT +GGAGCACAATTCGATTGAGCAGTTGACTGGTGGAGTGCTGGCGAATGCGA +CTAATTTACAGACGGTTCGTAGACTTGTTTTTTTTTTTTTTTGAAAAAAA +ACACGCTGAAAAAATCTAATAAAACCCAAAAATTTGCATTTTTGTTTAAA +AAATATGAAAAATTGTTCAAATTCCTAGTTTTCAATATTTTCAACAAAAA +AAAATTCTAGAGCTTCCATGGTAGGCAGGCGCGGTTTCAGGGCCTGACGC +CGACCTTTCGCCTCTTTTTTGCATTTTTACGGGAATTTTCAAATTTCTAA +TTTTCCCCATTTCTATCAAATTATTGAAAATCAAATTAAAAACGCGAATC +GCGTATTGAGGCGAGAGGCACGCAGAGGTTGCCTTAAGGTCAGACAGGCA +AGCTTTTTAACGCCTAACGTAATTTTAAAACCTGAAACATTAGAAACTTC +CACACGTTTGTAATTTCACTGAATTTTACTGCACCTCTTCATAAATTCAA +TGTATTTAGATAGTGTAATTTTTAAAGGTGGAGTGCCGAAATTAAAGACT +TTGCTTTTTTAGACCAAAATTGGTCCTAAATAACCGAATTTCGTAATGAG +ACTTTCTGAAAATTTCTCAAAAAAAAGTTATGGCGGTTCAAAGTTCGGGA +AAATAAGGTCAATTTTCAGCTAAAATCAAAATTTTTAAAATTTTTTATTT +ATCACTTTTTGATAAATATTGTGGTCTTTGATTAGGCGGGGCACCAATAA +AAGTTACATTTTGTGCCCCACTGACCATGAATGTATTTAAATCAACGAAT +AAACGCCTAATCAAAGTATTTATTAAAAAGTGATAAATATAAAATTTAAA +AATTTTGATTTTAGCAGAAAATGGGCTTTTTTTTCTCAAACTTTGAACCG +CCATAACTTTTTTTTTGAGAAATGTTCATTACGAAATTCGGTAGTTTTGG +ACCAATTTTGGTCTAAAAAAGCAAAGTCTCAAACTTCGGTACTCCACCTT +TAAAGAACAGTGTAATTTTTTTCTATTTTCCAATCAGTGCAACTCTAATA +GCAACTCTAAACTTATTTCAATAAACTCTAGGCACAGTATTTTGAATAGG +CGATCGCGTGACAGTTTTAACCAAACATAGTCATGATGACCTTTTGTCCT +TACAGAATCTTCTCAAGTTCATGCACACACAGGTGTCATTTACTCTGTCA +AGTATTGTATAAGTGTGATCCCGAGAGTATTATAAATGGTAGTTAGACCA +CCCTTATGGTTAAGTTGTTCGTATAATTGTAGGGGTGGGGATCTTACCAC +ATTTATACGGCCCCCCTCCTATTGTATTGTATTGTTGCCACCAGTCGTCT +TGAGAATCTCTTTCAATCCGGGGTGACAGAAGGTGTCATATTGTCGGAAT +GTGTAATAGGTGGGTCTCGAATGGATATCACTAACAGCTGTGAAGGGATC +CGAGAAGGGTTTTCGGTCTTTCTAGGGGTTTAACTTTCCGCTGTCAATAT +TATTAATCTTACAAGGAAAGGGTTTTAGTTTACCGTCAGACTTTAAAACG +AGACATGTGTCATTTGAAAGTGTTCCATAAGTGTATGTCACTCCAAAATT +TCAAGCGGCAAAGCTCCAGTCTCAAACCCTCTAGCATCGATCTGAAAACG +TTTCAGTGCATTTTTCACTACTTTGAGGCAAGTAGAATTTCTCCAAAATG +TTTTTTTTGCAAATCTTCAATGTTTTTCAGAACGTTTAAAAGAAGGAAAA +CAATCTGGAAAATTTTTGGAAAATTTTAAATTTTTTGAAAAAAATCTGAA +ATTTCTTGGACCTGGTGGCGTGAAGAAATGTTCAGATTTTTTTCAAAAAG +CTTAAAAATTTTCCAAAAATCTCCCAGATTGTTTTCCTACTTTTAAATGT +TCTGAAAAACATTGAAATTTTGCATGTTAGTACGATTTGATAATCGTGTT +ATAATTACATTACACATACATAATAATCAATTGAAATATACAATTCTTAA +TTATAACCTGAAATTGAGATTAGATACCTTAGACAATACAACAAATAAGA +ATGTGATCGATTCAGCAGACCCCTATTTGTGAAAAATGCCTTCTAAATTT +TATTTTACACTTCTCCTAGTAGATGAACAGCACCTGCCAATAATTTCATT +GACAGCCGGATGGTTTTTGGCTCCTCTAAGACAGTATAATCCCGTCTCCC +CCGGGGGGAAGTGGTGTCAAATTGCTTTGCGGAGCAGGTGCTTTTTTCTG +AATCGAATTGGCTTATTGGTGACGGAAAAACCCCTAATAGAATTGATACA +ATTTGGTTTTCAAGAGGATTTGGGGAAGGGTTTAGAGGGTAATTGAAACT +GAGTAGATCTTCGTCTGTCGTGGAGATCAGAAGATTGAGGGAAGTACTGG +GTTTAAGGGGGTCAAGGAGTACTGTAGCGCATTTCGAATACTACTTTAGA +TAGTTTAGGTATTATATCAATAGGATAATATATTATCAAGTTGCACCAAA +ATTGGAGATTCTAGTAGTGCATTTTCTTTATATGCTAGGTATGTATAAGT +TTCTAATAAGTGTATATACCTACCATGTACCTAGGGGGAGTAGAGTTTGT +GGGTATTTTGCTTAAATAGACTAAAACGTGTCCAAAACCACCGAATTTCA +AAATGAGACTTCACAAAAAATTTCCAAAATTTTTTTTATGGAAAAAAGAG +CAAAATTTAACTAAAATCCGAAATTTCGCACAGTTTTCTTTGTCACAGCC +GCTGGATTTGAATTTTTCTGAAATTATCACCCTTTAATCCTTATTTTAAT +AATTTATCTCGCGGAAATTCGTTGATTGAGACAACTTTTAGGCCGATAGG +CATCCCATCTTGATCATTTTTGGATGCCTATCGGCCTAAAAGTTTTTTAA +TTTCAGAAAAACTAAAATCCAGCTGCTGTGACAAAGAAAAGTGTGCGAAA +TTCCAGATTTTAGCAAAATTTGACTCTTTTTTTTCTCGAAATTTTGACTC +GCCATAAAAATTTTTGGAAATTTTTTGTGAAGTCTCATTATTAAATTCGG +TGGTTTTGTACCAGTTTTAGTCTATTTAAGCAAAATACCCACAAACTATT +ACACTTTACTTTAACAAGACACACAATAATTCACAAATGGTGTAGTATCA +TGCCGGAATTTATATAGGATTGATTCTTGAAGAACGAAATTTTAAATAGA +TTATTGCAGACTATGTAACACTATTTGTATAAACAATTAACATAGTGTAT +TGAATAATGACTTTATTGAAATTAATACAGTTTTTGATATACCCATCTTC +TATTAGTATATCATGCAATACTAATAGGTAATATGCAATATCACTTTAAT +TGTTATTTCCCATGCGTCGTGTTTATACAAATGCTTTATATACTCGAATA +GTCTATAATAATCCAATTAAACTCGAGAATCCCAATACAGAATATAGTGT +TTACCAAAAACACTTGTGTTATTATTCTAATATACATGCACACACACACC +CACACACAGGTTTGACACCAGTTCTACTAATATTTGCATAATACCATTGA +GATACCTGAAGTACCCTATAGATATGCACGGGATTCGTTTCGGGCACTGC +CACGGAAAATATTGAAAAAGTGTGGTAAATTTACGAAAAACAACAAAAAA +AATGCGATTTTCCAGAGAAATACGAAAAAAAAGAAAAAAATATTTAGAAA +ATTAACAACAAAAAAAAAAATTTTTTTTTATTAAATAATAAAATGTGTTC +ATTCTGTTTTTCCCCTTTCAGTTAAACTAGGGCTTCCATGGTAGGCAGGC +GCGATTTCAGGGCCTGCCTGAAACCTGCCTGCTTCACGCCGGCCTCAGGT +CGCCTTAAGACGGCTGCTAAAAATTTGAAAAAAAAATTTCAAAATTTGAA +TTTCCGCGCTTTTTTCGAATTCCTAGAACGCTTTTTTTTAATTAAAAAAA +AATTTCAGTTGGACCTTTCATCGAATCAACTTCGAGTTTTTCGAGACGAA +GTACTTCCGGAGAATTCGAAAATTGGAAATTTGAGACTTTCCAACAACTC +TTTGGAGCTCCTCGAGCCGTCGAGCCTGAGCGGCTTGAAATTGGGTAATC +TAAATTTATATGAATTTTGCAAATTCTAAAAATCCTAATTTTTTCTAGAA +TCCCTTGATCTGAGTCATAATAAGCTGACAGAAGTGCCCGCCGCAATTGG +AAAAGTCGAGCAGCTGAAAAAAGTGGATTTGAGCCATAATAGAATTGCGA +AGGTTTATCAATATGTGCTCAATAAGATTAAGCAATTGCATACTGTTGAT +TTGTCGAATAATCAGTTGCAAAGTGTGAGTTTTTTGTTGATAAAAATTTA +AAATTTGAATTTTTTCTTTTTTTTTAATTATTAATTCTGAAAAATTCAAC +GAAATTTCCGAAAATTACTTGAAATTTAAATTTTTATCCAGAATTTAGTC +TATAAAAACGAAAAAATACGAATTTTCGATTAAAAAAATTAATTTATTTA +AAAACACACTTTCGAAAAAAATTTTGAATTAAAAAAAATTTAAAGTTCCT +TAAAAAACTATTTCCTCAATTTTTTTTCTGAAATTTCACTCTTTCATTTT +TTAATTCATTTTTTAAGTCTATAAATACGAAAAAACACGAATTTTCGATA +AAAACACATTTTTCAAGTTTTTAAAAATAATTTTAAATTGGAATTTTTCT +TTAAAAAATTGTTTTTTATAAAAAAACACATTAATGCATTTTTTAAAAAA +TAATTTCTTGAAATCTTCCAAAATCGGTTGTAATTTTAGCGAAAATAACT +ATTTTTTCCAGTTTTTATTTAAAAAATCCCTCGAAATTTGAATTTATCCA +GAATTTAGTCAATAAATGCGAAAAAATACGAATTTTCGATTAAAAAAATT +AATTTATTTAAAAAACACTTTCGAAAAAAAAATTTTCAATAAAGAAACTA +GTTCTTAAAATTTTTTTTCTGAAATTTCACTTTTTCATTTTTTAATTCAA +AAAATTTGAATTTATCTACAATTTACTCTATAAATACGAAAAAAATACAA +ATTTTCGATGAAAAAACACAATTTTCAAATTAATAAAAATATAATAAAAA +ACATATTACTAAATTTTTAAAAAATAATTTCTTGCAATTTTCCAAAACCG +GTTTTAATTTTAGCGAAAATAACGATTTTTCCAGTTTTTATTTTAAAAAT +TCCCTTGAAATTTGAATTTCTCCAAATTTTTTCTTGAAGTTTTTAAAAGT +TCCATCATTTTCTACTGGAACTTTCAAAAAATGTTCCTTAAAAAATCTCT +AATTTCCGCTAATTTCTACGTAAAATTTCAGCAAAAAAACAACGACATTT +CATGTTTTTTTGTTAAAAAAATAATTTTCTTGAAAATTTCTTTGGAATTC +GATTTTTTTTGAGTTTTAACCCAATAAAATGTATAATTTAAAAATATAAA +AATTCCAGATCGGCCCCTACATCTTCTCCGACAGTTCTGAACTTCATTCC +CTGGACGTGTCGAATAATGAGATTTCACTGCTGTTCAAGGACGCTTTTGC +GAGATGCCCAAAGCTGAGGAAAATTTCGATGAAAATGAATAAAATTAGTG +AGTTGAAGCACGAAAAACTGCCCAAAAATTAAAATTTTGAAATTTTTGTG +TTTAAAAACCTAGAAAATCGAGATAAAGTAGGCTTAAAGTTGCTCAAAAT +CCGCAGATTTTTTGAAATCGATTTTGAAAAGTGCACATGGAGCTAAATCA +GACTTCAAAATTCTCAAATTAATTGCATTTTCACTCGAAAACCTCTGAAA +ACTGCCTTCTTCCTATATTAAATCAAATTTTCTTTCAGAATCCCTCGACG +AAGGTCTCACAGAAGCTTCCGGCCTCCGACGTCTCGACGTATCTCATAAC +GAGATCCTCGTGCTGAAATGGTCGGCTTTACCTGAAAACTTGGAGATTCT +CAACGCTGATAACAATGATATCAATCTCCTGACCGCCGCCTCAATGTCCC +CAAGCACCGCAAACTTGAAGTCCGTTTCGCTTTCCAACAACGGCATCACC +ATAATGAATGCGGACCAGATTCCGAATTCGCTCGAGTCGCTGGACGTGTC +GAATAATCGACTTGCAAAGCTCGGGAAGACAGCGTTGGCCGCGAAATCTC +AGTTGAGAAGGCTCAACTTGAAGGGCAATCTGCTTACCGTAGTGGCCACC +GAGTCGATGAAAGTCGTAGAGGCTGTGCATCCGTTGAAAGTGGAAATCTC +GGAGAATCCTCTGATCTGTGATTGTCAGATGGGATGGATGATTGGTGGAG +CGAAGCCAAAGGTTCTCATTCAGGACTCTGAAACCGCAAGCTGTTCCCAT +GCCGTTGATGGGCATCAGATCCAGATTCAAAGTCTCAGCAAGAAGGATCT +ACTGTGCCCATACAAAAGTGTATGTGAGCCGGAATGTATCTGCTGTCAAT +ACGGAAATTGCGATTGCAAATCCGTATGCCCCGCCAATTGCCGATGCTTC +AGAGATGATCAGTTTAATATCAACATTGTCAGATGCCACGGGAACTCATC +AATGGTGCCCAAAAGAGAATTCGTGGTCTCCGAGCTCCCGGTCTCTGCGA +CAGAGATCATTCTGAGCGGAGTCACCCTTCCACAGCTCCGAACTCACAGC +TTCATCGGAAGACTTCGTCTCCAGAGGCTTCATATCAATGGAACCGGGCT +CCGATCCATCCAACCGAAGGCTTTCCATACTCTTCCAGCACTGAAGACGC +TGGATTTGTCGGATAACTCGTTGATCTCGCTGAGCGGGGAGGAATTTCTA +AAGTGTGGAGAAGTCTCGCAGCTTTTCCTCAATGGAAATCGATTTTCCAC +GCTATCCCGTGGAATCTTCGAGAAGCTTCCGAACTTGAAATATCTGACAC +TTCATAACAACTCCCTCGAAGACATCCCTCAGGTTCTTCACTCGACGGCG +CTCTCCAAGATCTCCCTGTCATCGAACCCCTTGAGATGCGACTGCTCGGG +AGGATCCCAACAGCACCTTCACCATCGTCGTGACCCAAAAGCTCATCCAT +TCTGGGAGCATAATGCGGCCGAGTGGTTCTCGTTGCATCGGCATCTTGTC +GTTGATTTCCCCAAGGTTGAATGCTGGGAGAACGTGACGAAGGCCTTCCT +GACGAACGATACGACAGTGCTGAGCGCCTATCCACCTAATATGGGAAATG +ACGTCTTTGTGATGCCTATTGAAGGTTGGTTTAAAATTTTTAAAAAAACG +CGCGTCAAATATTTTAAAGTCTTTTGTTCGAAAAATAACCATTTTACAAT +ATGTAGGATATATCTATAACAGCTACTGTAAAAACTCCAGATGTTTGAAT +TTTTTTAAAAATGCGACGTGGTAAATATTATATTGATTACATATTATTAT +TACAGTGTATTTTTTTCCACTTCTACGACTTTAAAGGGGGGCGCATTTAC +GCGCGATGGTCCCAGCATTGGTCTCGCCACGCACCCCAAAAATCAATGGG +TGGCGCGTGTCGAGACCATCGCGCGTAAATGCGCCCCCCTTTAAAGTCGT +AGAAGTGGAAAAAAATTCACTGTATAATTATTAGTCAAATGATACTTATT +ATGATATTAGAAATTAAAAAATTAGGTTTGAACATTTTTTTTCCTCGATT +TTTTTACGGTATTTCACCATGTATGCGTTATAAATACAAATATGATCCCT +ACCTTTTTATAACTTTAAAATAACTTTTAAAAAGGAATATAATACATGCA +CAAGCACCATAAAATTTCAACGTTTGCTTTTTCTGGTCCGAAGAATTTTT +TCAATACGTTTACTTTATATATCACATATACAAACAATATACTGAGAATG +CGTATTGCGCATTATATTTGACGCGCAAAATATCTCGGAGCAAAAACTAC +AGTAGTCCTATAAATTCCTACTGTACTGCTTGTGTCGATAGAATATTAAA +ATTGCAAAAAAAATTTAAAAAAACGAAAAAAAAACAAAGTATAAGGGAAT +ATATAGCTATTCCAAAATAAATCAATTTCAAAAATCGAGCCCGTAAAAGA +GAAGGACTTACTGTAGTTTTCCCTACGAGATATTTTGCGCGTCAAATATG +TTGTGAAATACGCATTCTGAAGATGTAGTGTACTCGTAATATATATTTTT +TAACAATTCAAACATTTCCAGAATTCCTGCGCGACTACAACTCAACAATC +TGTGTTCCATTCTCATCTGGATTCTTTGGACAAGACCCTCAGAATAGTAT +ACTCTTTGTAATAATAACTATATCGATTGCTGTTCTCCTCTGTGTCCTCG +TTATTCTCGCAATTTCATTTATTCGAAAATCTCACGACGCAATCAATCAA +CGAAGATACAAAGCATCATCTCTAAATTGTTCAACATCAGCCGGCTCGTC +GCCTCTTCCGGTTCCGCTGTTGAGTTATCACGCATTTGTGAGCTATTCGA +AGAAGGACGAGAAAATGGTGATTGATCAATTGTGTCGACCGCTGGAAGAT +GAAGATTATCAGTTGTGCCTGTTGCATCGGGATGGGCCGACTTATTGCTC +GAATTTGCACGCGATATCTGATGAACTCATAGCTCAGATGGACTCGTCGC +AATGCTTGATTCTTGTGTTGACTAAACACTTTTTGGAGAACGAGTGGAAA +ACGCTGCAGATTAAGGTAACAAATTCAAACTTTCAGTTTAAAATTGATAT +ATTCGTAAAAATAAGATGTTCTTAAAAATTCTGAGAATGCGTGTTGCGCA +AAATATCTCGTAGCAAAAGCTACTGTAATTATTTTATATGACTATTGTAC +CGTTCAAAATTACTATCCAAATATTTGATTTTTTGTTTTAAAAAATTATT +TGGAATTTACTCAAATATTGAAAACAATATTATCGAAATTCCAGAAAATT +TGGTGGAAATTCCGAAAATTTCAATTTTTTCGCTAATTTTCGAGAAAAAA +AAAATTAAAATTTGGATTATATGAAATAAATTTCCAAACATTAAATTAAA +AATTTTTTTTTTTTGGATTTTCCAATCTCGAACCTTCAAAAATTGAATTT +TTTTGAAATTTTTTTTCGGAAAAAGTAAAAAATGCTCGAAATATCGACAA +AAAGTTGAAGTATTTTTTTTTGTAAAATTGGAGATTTTTGAGATAAAAAA +TCTGAATTTTCATTCAAATCTTGAACATCAAAATCAGCAAAAAAAATTGC +TATAAATTTATTTAAATAAGATTTAAAAAGAGTAATTCGCTATGATTTCA +AATTTTCAAAAAAAAAAATTTTTTTTTCAAGTTTTAATTTTTGAACACTA +TCAAAAAATTTATTTTTAAACCAAAAAAATTCCGAATTTTCTGTAAAATC +TCAAAAAAAAAACATTCCTAGAAATTTAATCGAATATGATTTAATAATAC +TATTTTTAAATCATATTCAATTACATTTCTAGGAATTATTTTTGCTAGAT +TTCAAAAAGTGTATGAAAAATTAAAACTTTTTGAAAAAAAAACTGTTCTA +AATATAATTTATAACACCAGAAATTCACTAATAACACTCCACATTTTTCC +AGACCTCCCACCAACTATTCGCCAAAAACCGTGCAAAACGAGTGATCGCC +GTGCTCGGCGACGGTGTGGACGCGAATCTGCTGGACGATGAGCTCGGACA +GATTCTACGGAAGCACACGAGAATCGAGATGCGGAGCCATTTATTCTGGA +CACTTTTGCACTCATCACTTCCATCACGACTTCCATTACCATCGAATAGT +GGCGATGATTCGTCTCAACTATATTCGGATATCTATGGAATTGTGCCTTC +CGATGTTGTTTAGCTTACAGTTTTCCCGTTTAGGTCACAGTTTTTAGTAT +TTTTTTTCCTCTTCCAAATGTACGAGTTTCCATTATTCACGAGGTTTCTT +TTTCACCCCCAATTCTTCTGTGCACAATTTGCCATTTTTTGAATTTTTAC +AACAATACCGGTACTATATTTTTCGATTTTCTTTCTTTTTCTATGAATCT +TGCCATCATTCTCTAATAATTGACCAGCGATTATATTTTTGATTTAATAA +TTGAATATTCTCGTTTTTCAGTTCAAATTATTGCTTTTTTCTGTCACCAC +AAATTCAAATTCTCGTCCTACCCTGTGTGATCTTCTGTAATATATATATA +TTAATAATCGTCGTTTCTTCTTGTTGTCATTTGCGGATGCTTATGAAGCT +TGTATTTTAATTTTTTGTTTTGTTTTTTTTCCTGTTTCAGCTGCAAAAAA +TTCGGTAGAAATTCTTGAAAACACGCAAAAAATGAATAAAAAAAATAGTA +TATTAGCTTGTTCGAGAGGAGTTCACAAGCGGGTGGCCTAACATCTCCGC +GGCCGCCCAGTGGTGTACTCCTCTCGGGTGAAAGAATTCCCATTTTATCA +TCAGTTTTTCGGCCTATTTTTTCAGTTTTTCTCAACTAAATAGTCAATTA +TCTCTTAAATAATGTCGAAATTAATTTAATTTACACATTTTTCCAATAAA +ATTCCAATTTTCGGTCATTAAATTACCCCTTTCGAATTTTGCTCTCAAAA +ATTAAATTTTCATCGATTTTTAATTCTCAAAATTCTTGAATTTTCAGCGA +AGATGGGCAAATTCAGCAATCAGAAGAAAAATCGTGTCAAGAACAAGGTG +GCGGTGACAGTAAAAAAAGCGCAACGCATGAAGGCAGACGCTAAAAATGC +CAAAAAAGACGGTGAAGTGGATGTTGAGATGAAGGAGGAGGTGGTGAGAG +TCAGAGGACTCGCCGTATCGTCGCTGGTGAGAAAAAAAAGGAAAAACTCG +GCGAAATTCTTGATTTTGATTTTTTTTTTCAGAAAAAATTGGCCTCCGGT +GAGCTGCAAAACGTGCCAAAAGTGAACGAGAAGAAGATTATCCGCAAGAC +AGAGCTTCCAGTTCGAGAGAAGTAGGATTTTCTCGATCTCTCCAAACAAA +AAAATTGTTTTTTTCAATTTCAGCAAAAAGATCCTGGACGCTCCGACTGG +AAAACGTGGCACCACTGCTCAATACATCACAAAAAAGAAGGCAAAGAAGA +TGTACAAGAAGATGACACACGACGCACGCGACAAATATCGAAAAATTCAG +GCGGAACTGGCCGGAGACGGTGAAGATGACGAGGAGGGTGAAGCCGAGGT +GATGGAGCAGTGATTTTGGATTTTTCCGCGGCATTTTTAAAATTGTTTTT +TTTTGTTGATTTTGTTACTGTTTTTCATTTTCCACATAAAATAATCGAAA +ATTTATTTATCACAAAAACTTTTGCACAATTTGCTCAGCTGAGTGAGCCA +ACTGTTTGCCACGTGTCACGATTCGATGCATCCATCCATTGGGCTCCTCG +AGCTCCGCTTTCGGAGCCTGTAGCTGCTTTAGAATTATTGTCCAGAGCTC +AGAAATGTTCATCGAGTACTGCGCGGAAACTTCGACGAAATTGCACTTGT +GTACTTTGGCCAGGCAGGCTCCTTCTGGAAAAATCAATTTAAAAATCGAT +AATTTGAAGTTCCACGTGGAGCCGCGACGCGGCACGCGTTGCATCGTTTT +TTTTGGTTGAAAAACATGGTGCATCGAAGAATTTTCCTTTGACGATTTTA +TACGCAATGCATCACATTTGACGAACAAAAATTCAAAATACTTTACTTTG +CAAACGCGCTCCATTGATAAACTTATGAAAAATCGATAATGCTCAAATTT +CACAAAATTTTCCTCCATTTGAAATTATATAATTGTTAAACAAAATTAAT +AAAACCAAACATTACGCGCAGTTTCCGATAAATTTCGATTTTTTCAAAAT +GCAAGCGCGCTCCATTGCTAAACCTTGAAAAACCCACCCATTTTCGACAC +CACCGTATTCCGTTTCAAATCGATTTTATTGCCAATCAGTATAATATTGG +CTCCGCGAGCAATTTTTCGATTCAAAAGCCGACTGAGCAGGTCTGTGGCA +CACACGAATGATTCTCGATTGTCAACGTTGTACACTATTGCGTACATTGT +CAGTGATGACGCGAATGGAGAATTCTGGAAAAAAACAAGAGTTTAAAGGC +GCAGGTGGGTCTCGCCACGATCCATGTTTTTTTGCGGGAATAGTGGAAAT +TTGGAGTTAGTAAAAAAATCAAATTTGTGTAATTTTTAATAAAATCGGTT +CGCAAATGCGCTAGTACATCAGATTTCACGAGCAAATTTCATTTTGTGAG +ATTTGCACCAAAGATATGGGCATTTGAACTGATTTTTTAATGGTAAACAC +GCGAAAAAAAATACATATCCAAAAATTGAAAAAATTTTAGGTTTCACAGT +CTCCTCGGCATCGAAAGCGCAGTAGTAGGGGTGGCGATAGGGCGCCCTGC +TAAATTTTCTATTTTTATGGTCTTTCTTTTCGTTTTGTGCTAATGAACAA +AAGTTAAGTTCGAAATCTGCGAAAAAAATCGTTTCAACGCTAAGAAACGA +AGAATTGTATTTCTCAACGGTAAAAAGATTCACTCCTGCGCCAAGGTGAC +AGCAAGTGCGCCCCAGCCCAATTCGACGCTGAAGAGACTGTGGGTTTAAA +AATTTAGAGAAGTCGCAAATTTTTTGTTCAAGATATCAGCCTAAGCTACG +GTTTAAAGGCGCACAAGCACGTGGTGTCAAAGTGTCCCGTTTCGGTGTGA +TCTACCAAAAATGCGGGAATTTAGACGCAGACTTCTCAGCAGATTTCGTA +TGGTTAAGAGTGTGCTGACGTCACATTTTTTTCTGCAACAAATTCCCGCA +TTTTTTGTAGATCACACCAAAATGGGACTGTTTGACAGCACGTGCACAAG +CAGATCACAAGTGGGTCTTCGAGTTATCCTCCCCAAATCCTGTCCAGTAG +AGCGCACTTACCTCCAACGTGGCTTCCAGCAACATTTCCAACTCGATTTG +CTCGTTATTCAACAGGAAATTCATCGTTTTCGATGAAGTGTCATCTCCCT +CATTTGACTCATTATTGTATTGGGTGACGAGCCGCGTGGCAAATTGGTTA +ATTGCTGACAGCAATGTTTTCTTCCCGCTATTCCTTGATCCATAGACACG +TAGAACCACATGTTGCATTGGAACATTCGACGTTTCTTGGAATAGCCAGA +CTTCTGGACACGTGGCTCGGCGATCTTCTGAAAATTTTTAAATTTTCAAA +AATTTGGTTAAAAATTTCAAAGGAAAATCAATAACAAAGCTACTCCAAAA +TTTTCAGCCTGATTGGTTGGAAAATGAGCAAGTTACAGCGCTTCAAGAAT +TCTAGGCCACGGTCACCAGGGAGTGGTGGCGGTGACCCTCTATTTCATTT +TTAGATTTTTTAAATGGGAAACTCGAATTTAAATGTGAAACATCTGGAAC +ATTCCAAGAAAAATTCAAAAAAACTCTCTAAGGAGTCGATAACCCTCCCC +CAATTCCTGAGATGTGACGTCATCAGGGGGAGCCCGTGACCTCATAGCTT +CAAATTTGAATTTTTCAACGAAAAGTGTGAAATTAGATGTAAAATTACTA +GGAAATTAGAAGAAAGATTAGAAAAGAAATTTCGGGGGTGTCGCTCACCA +CCCCCCCCCCCCATTTTTATAGTGTGACGTCATAGAAAGTGGGTCCCCGC +TACCTTCCATTTTCAAAGTTTTTTTATTTTTCCGATGATTGTATTACTGT +ACTCACTGTAATTATGTGCAACAACTGGTTGTCCAGTGGAGCACGTTTGC +TTATACCCATTGTCCGTCACAAATCCATTCTTAATTCCAAAACTTCGAAG +ACTTCCCTCCGGTCGTTTTTCGACGTCTTCGATGTTGTTTTGGTGCATTT +GTAGAGAGTATTGGTATCTGGAATATTAAGGGGAAAATGGTGAAAAAATT +CAGAAATGTACAGGTAATCGAGAAAAAAAGTTAAAACTTTTTTTGAACTA +AATTTTTTTTTCAAAATTTCAAAAAAAAAATTTTATTTGAAGAACTTTTT +TATAATGTTAATTTTTCTGAAATTACTTAACTTTTTCTCTCAAAACTTGC +TCACTGAGTTTTTAAATAGATTTCTGAAATTGTCCACGTGAAGTACACTC +CCAATATATCAAAGGAGCGCATTTGCGAACTAATTTTATTAAAAATTTCA +CAAATTTATTTTTTTTAATAACCTAAAATTTCCGCTATTTTATCGTATTT +TCTAAAATAAATAAAAAATTGTCCAGGAGGAGTACATGGCCAATTTATCA +ATAGAGCTCATATGCACACTTGTTAAAAAACAAAAAAAAAACTTATTCAC +CTTGGCGGTGGGTACCGCTTTTTCACACGACGAGGCGAGTTTTCCGAGCT +GAAAAATGATACTTTTGGCTGGGAAGTTTTAGAATTTTGGGGAAAATAAG +CATTTCCGGTGAAAAAAATTGTTTTTTATTGGAATAGTTTTTAATATTCT +AGGCCATGTCGTAAAGAATTGAGTCAAAATTTAAATTTTTGAGGTACGAG +CTTCCAGTTCCCCCCACAATTCCCCCTATGGCCTAGAATTTCAGAAAACT +CTACCATCGATTCAAACTCTGTTACTTTTGAGGATAAGGGGTTCCGGACG +CCCCAAACTTCCGCCCGTGGCCTAGAACTCCCAACTTCTTCCACCGACCT +GGACGTGGTGCTCGTACTGGCAAAATGCTCATCAACATCTGGCAGTAAAT +TGTTCAACCGTCTTGGGGACACGGTACGCGGGGTCGACGGTAGACTTCGG +CGACTGATCGGCGATGTAGGAAGACTTCTGAAAAAAAATCAATCAATAAA +ACAACGACACTCTGCTCGTGAGGATCCGCCCATTCCGCTTGTTGTTTACC +AATTTCTTTTAAAAAAATTCTACAATGCGCAAAATTAATAGAACTACCTT +CTTATAATTTTTTTTTAACTCAAAATTTTCAAAAAAACAACGACACTCCG +CTTGTAGACTCCGCCCACTTTCCAAAAAGGACAATTCGGAGTGTCGTTTG +AAAAATATCCTAAAATTTGAAAAATTCATTTTTAGTCTCAAATTTTAATG +AAAATTACGTGAAAATCTATAACAACTACGACACTTTTGGCTCCGCCCAA +AAACGTCTTTTGGCTCCGCCCGAAAACGGGGCGGAGCCTGGCACTAATAT +TACAGTTTTTATTTCCATAAGTGATTAAAAAATCAACAAAAAAATTATTT +AGAAAGTATCTCAATTATTGAATGAAATTTTATAAAATCTACGACACTCC +GCTTGGAACCCCCTCCCCCTGCCAAGAATGGGGCGGAGCCTAGAACAAAC +GGAGTTTTTGCAAGAAAAATATTGCTTGAAATTTTAAAGACATTAATAAA +AATCCGAGTTTTTAGAAAAAATTGGGCCAAATCGAATAATAAAAAATACG +TTACTCCGCTAATAAAACCAGCTCATTACCAAGAAAGGGGCGGAGCGTAT +ACAAACGGAGCGTCGTTTGAAAAAATATTTTTTGGAAAACTAAAATGTTC +CAGCGGGAGGAAGCTTCTGCAAAGGCAATCTAATTTTTTTCCGGAAATTC +AATTTCCTCAGGGTTCTCTCTGCAAATTTGTTCACGAAAAAACTCGTGGT +GCTGTGCAAATGCGCTCTATTGATAATTTCATCTAGAGAGCGCAATTACA +TCAAATTAGCAATGGAGCGTTGTTGCATACCTTCTCGTTGCAGCGGGAGA +CGCTGGTGACGGAGGTGATAGCCGTGATGAAAATTGTTGGGGTATCGCCA +GCGCAACTGGAAGGGAAACACGACGATTCGACATTTTTCTGTAAAAAAAT +CCATGATAAAACTAAAATTTAAAGAAAAAATAATGTAAATAAAAGTGGGG +AAGTGGCTAAGCGGGGACACAAATACGCGGGAAATCCGCTTATTTTTGCT +GGATTTGACGTAAAAATCCGAATCAACTGGCACTCGACGCGTTTTCCAAC +AAGAAAAAACTAAAATTTCATATATTGGTGGCCTAGAAAATTCGAAAACT +GTTCAAGCTTACGTAAAGTGTGTATTTTCCATATTAGAGAATAAGATTGG +AAGAAAAATAAAATATTGTAATTTCTAGGCCACCGCAAAACTTCTAAGTC +ACCTATGAAATTTCTAGGCTACCGTGAAAATTCTAGGCCATCATAAAAAT +AAAATTTATATATTTTTGTCCTGAAACTAAGTCCACTTCCGCCAGAAATA +ATAAAAGCAACAAAAAAGACAACACAAAAAATTGAGAACTCTTAAGAACA +AAAGAAATCCGACCCGAAATCGAATACCCCACGAAAATTTTCGGAATTTA +GAAAGAAAAACTATTTTTAGACACTTTTTTTCCTTCAAAAGGAGGAACTT +TGTTGCGCGGCCTAAAAAATAGAAAACTCGGCCACCGATTTGTTTGCGGC +CACGGGACACTCCGCAGTTGCAAAGGCTACAGATGCAAATACTGGAAAAC +TAGGTCACCAAGTGGAAACCTTGGTCATCGCGTGGAAAAAAACTTTGACA +AAAAATTTTTGAAAATTTTATAAATTTATTCTAGGCCACCACCTGTAAAC +CTAGGTCACCATGTGGAAGGCTAGATCACCAAGTGGAGCCTAGACCAGCA +CATAGGCCTCTAGGCCACCACGTAGGAAATTAGGTCACCAACTGGAAAGC +TAGGCCTCCACATGATAAATAATATTTTTTGGAATTTCGTTTTGACCAAA +GAAACTTGTTTTTACCAAAATATTTGAAAATCGTTTTCAAGGCCGTCCGG +TGAAAACTGTGTAAACCTAGGCCACCAAATAGAAAGTCAGGCTGCGACAT +CTAAACTTAGGCCACCAAGTAGAAAGCTAGGCCATCAAGTAAAAACCTAG +ACCACTATGCCAAAATAGATGCCTTCTAAAAGTTTCAGGGAAAAAATGTT +TTTCAACAAAAATTTTTAAAATCGTGGCCGAGTGGACTTTAATAAAATTT +ACTTTTTCAGCCACGTGGCAGAGGGATATCGGAGCATCGTTTGAATTTTC +TAATTTCTGAAAGAAAACCGGAACACATTGCAAAAATACGAAAAATATAA +CTGAAGCTGACATATGAAATGAGTTCTATGCTCCCCGCCGCCTATTCTTC +TCATTTTTCTGCTTATTTTTGTCGTTGGGGGGATGCTGGTATCATATTCT +TCGTCCCCTCTTCTTTCATTGCCAGTCTATTCAGTATTATAATTAGCGTG +TATTCCCTATTGGATTCTGCTCCCCGTCGTTTTTTTTTCTATGCGAAAAA +AATAGAAAATACGAGGTGAACGGGAATTTTTATGAAAACGAACGAAGAAT +TTGAGTTTTCTAGGCCACCAAATTGAAACATAGGCCAGCAAACGGATCTC +TAGTAAAAACCTAAACCACAATACGAAAAACTAGGCCACCAACGAAAAAT +GGGAGATTCCGCTTGTGTGTTCAAGCATTTTGTAAAATTCTAGATTGTTT +TAAAAACTTAATTTTTCCAGTACAAAAATCGATTTAAAAACAATAAATAT +GTCAAACTCGTGACGTTTGTCAATAGAGCGCGTTTGCATGTCAAACAAAA +CATATTCGGTGTAGATTTACGGGGACACTTTACAAAACAAAAAACCTTCA +CAAGGCTCCAAATAAGAGCTAGAAAATGGAACAAATTTCCGTTTTTTTTT +TGTTGGTGAGTGTCTTGTGAGGAGGGGACCGCCCGTGTCTCTTCCAAAAA +CATTATTAAATTAGTGTGACGTCATCACATTGAAAAACAACAAATATAGT +TCGAGTTTTGAAGAAAAATTTCGGAATTTTTCTGGTGAAAAAATTTCAAA +AATTTCAATTTTTTTTTAAATCTTAAAAAATTTTTTTATATATTTTTAAA +TTCAATGTTTGATCTGAAAACCAAATTTTCACACAAAAAATCTGGTTTTT +GACGTCTAAATTTGCTTTTTTTCACCCAATTACGAGGTTCTCCGTGGGAA +GGTGTGTCTAGACACTTGAACTTTTGCTTTTTTATTTTTTTTCTAATTGA +AAATGATTAAGCTAGATATATTTTCTCTCTTTTCTTAATCAGAATTGTTT +TTGAAGATTTTAAATTTTTACACTCCCGTGCAGCAAATGCGCTCCGATGA +GAAGTATGGAAAATTACAACTGGAGATTTTCAAAATGTTCAATTAAATTT +TGCGTTTTTCTTTTAAAGGTTCAAGAGTCTAGAAAACTACGAAAAGGTGC +TGTGACCTTATCGATGACGTCATCACAATTCTTGAAAAACTGGGAAAATG +AGACGATGTGGAAAGAGGGGATTATTTATGCTTAAATAAACTTTTTGCAC +TAATTAATTCATATAGTTGTAGTGCTTCTTTATATTTTAAGAGAAATTGC +AAATTTTGCACCCAAAAAAGTAGACGGCCGAGTTATGGGAAAACTCTTCC +ACGGACACAAGACGTGGAAAACTAAAAGTTTCCGTTGTTTTTTATACGCC +CGCATGGCACATCCCCGCCCCAACAAAATTTTCAGGTTTTCAGGGTGAAA +ACATTTTTTCAGCTGCTGGGCGGCTTCTCGTGCAGCTGGAAATGTATTTC +CAGACGGGTTGGAACCGGGATTTGTCATTCAATTGTTGCAATTACGCTCT +ACCGCTAAACCTCGTTTGGACTCCACGTGGACAACACGGTGCCTTATTGT +AAATTTCTCTTCCATCTCCATAATTTCAGAACAAACCGTCGCTTTTATTC +TCCATAATATTATAATTTTATTTAAAAAAATCTGGAAACATTTATCGATT +TTTGTGAAAATCTATGTGAGATTATTGACAGAAATACAAGAAAATCGATG +CAAACATGCTCTATTGCTAAATAGTTCGTGTACTCTACGTCGACGACACG +ATTTCAAGAGTTTTTCGTTTTTTGAACAAATCATCTGTTATTATTGCAAA +ATTCGGTACATTACTCAAAAAAAAACAATAATTGATAAACATGTAGAAAC +ATACATGCAAACACGCTCCGATGCAAATTATTGATTCTCCAACTTTTATT +GTTAAGTTATCTTGAAAAAAAAACTGATAAAACGAGAAGTCCTTGGTGGT +ATCGGTCGCCTAGAAACAGATGAAAGAATGGAAAAACAAGTATTACGGGC +GGCTCCGTTTCGTATTATGGGGGGTGGGCCGCAGATGATCCTTTAGAATA +AGAAAAATGTCTAGTATTTTGTGATACTTGTGAAATATAACCCTAAACTT +AAAAAATAAATTAGGGCTCAAAAATGGTATTTTTCTAATGTAAGCCTACA +AGCACAAAGGTATTCAATTTTTTTTCAATAGCTAAAAAATTAATTTTTAA +ATTGTGATATCATAATACTTACACAAGTACCAATTTTGTTTTAAACGATA +GAATATTCCATAACTTTTGGGTAGGATTTTCTGCACTCGAAAAAAACGGG +ATTTTCAACAAAAATAGTGGACTTTTTAAAAACAACGAAAAAGTTTTGCT +TGGGACCAAGTCTAGCAGATTACAAAAACTGATTCTTCCAGTCAAAGATT +TTATATATCACTTAACAATTGTTTTGCCTACCTAGCAAATTCCGAAGTCA +GAAAAGTTGAATTTCCCTCCAACAATTTTTTTTCATAGTCAGCCAATTTG +CATTTCCCGCGAAAAAATTTACGGATTCACCACAATGGGTCTCCCACCAA +TAAAATTAATTATTCATTTATCTTCTTAAAAGGTCACACGAGATGCCAGC +GACACAGGGCAAGTGCGACCACTATCCCGAAAAAGACACCGACAGAACCT +AACGAAGGCTTCCAAAAATAGCATAGAAATACAAGAGACACAGAATATCC +CATGATGTTCTGTCACTTTCAACATCATTCTGCCTTTTTTGTTCCCTTGT +GTATGGTGACTATAATTTGATTGTTCTGAATAATCTGATGTCTACTTGTG +TTGTGGACCACTATTGATTTTTGCTGCTTTGGTTAATTTGAGGTAATACT +TTAACAAATTTGTTTTAAATATCATAGTCATTTTACAAATTTCAACAGTT +TTCCTATTAATCCGCTAAACCGCAACTAAAAATGAAAAATTAAAACTTTT +CTCAAAACTGTATGGGAAAGTTCAGTGACGGTTATGATAATTACAACATC +GTTAATGCAAATTTAACAGGTTTCGCAAAATTATATTCAAAAAATTTTTT +AAATCGTTTATTACGGTAACAAGAAATGTTGAGAATGCGTATTACACAAC +ATATTTGACGGGCAAAATATCTCAGAGCGAAAACTACAGTAACTCTTTGA +ATGAATTCTGTAGCGTTTGTATCGATTTACGGGCTCGATTTTCGAAATTA +ATTTATATTTGTAAAGTGAAAGCTATATTCAATTTTTCTTCGATTATTTG +TTGTTTTGTTTTATTGTGTTTTTGTTTTATTTTAATATATTTGTCACTTT +TCAAATAGAAATTAATATCGAAAATCGAGCCCGTAAATGGACACAAACGC +TACAGTAGTCATTCAAAGAGTTACTGTAGTTTTCGCTCTGAGATATTTTG +CCCGTCAAATATGTTGTGCAATACGCATTCTCAACATTTCTTGTTACCGT +GATAAACGATTTAAAATTTTTTTTAAAACTATTTTTTTAAGTAGAACAAA +ATTCAGAAAACAACTCGATAAAAATGTCCTAGTCATCCGATTAAAATAAT +TTTTTGAAATAAATAATATGAAAATTAAATTTTAAATATTAAAAATGTTA +TTGTTGCTTTAAAAAACGTTATTGGACTTTTCAAGGCGGCAAAAAAATGA +AAATAAAAATCGATTATTTTTTGAATTGTTGACTTTTCGGTTTTTAAATG +TTGTTGAAAAGAAACGAATTGTATATACGAATTTCAATTAAAAAGTTTAA +AATGTTTTTTAAAATGTTTTATTTTTTTCAGATAGATCAACTGAACTTCA +TAACTTTAAAAAGCCAGTCTGGGATGTATCTATACCACTCTATCAGACTA +CTCTTAGCACTAATCACAATGTACGACCCCGTGAGAGATTGTTGTCTGTA +CTGGATACTACACGAGTGGTAGAATATAAAGAAGTGTGGTGACAAGTTTG +GGATCTGAGTCCAGTAGAAAAAAATCATTCTACCGAAACTCGAAACTATG +AGCGACTGGTCAAAACTATGCATTTGACGACGTCTACCTGTTTTAAGTTA +TTGGTGGTGAGTGTGCCTTTGAAGAAGTCGCTCGAGCCTCGACCTTCTCC +GACTGGCTTGAACTGAAAGATCCTCGGGAATCATTTTTAGAATTTAGAGG +TGGAGTACCGTCTGTGGATTTTTTTTTGCTCGAAACGATAGAATACAGCC +CCAATATTCCGAACAGGGGTGCGCGGCAATTGCCGTGTGGCAATAGAATT +TTCGGCAATTTCGGCAATTGCGGCAACTTAGGCAATTGCCAAAATTGCCG +AAAATTCACAAAACCGGCAATTGCCGAAATTGCCGATTGCCGGAAATCCG +AATTGGAAATATAAATTTGATTTTTTTTTGTAGTTTTAAGAGCTTGAACA +TGCATTTTACTAAACAATTTTCTCTTTTTAAGCTCAAAATGGTTTAATCC +TTTGAAGATTGACCGTTTTCTTTTAGAAAATTACTGACAGAATATTAAAA +AACAATGTGACATTTTTCAATTTTCGATATACATTTAGGTTTGAAAATTG +CCGAAAATGCCCTGCAATCGGAATTTCGGCGATTTCGGCAATTGCCGAAA +TTGCCGATTGCCGGAAATTTTGAAAACCGGCAATTGCCGAAATTGCCGCG +CACCCCTGATACCGAATATAACTGTAAAAAATGTATTAATTTTTTTGTTG +ATTTTTTGAAAATTTTCATAAAAGTAAAGAAAGGGCCAAATTATGTTTGA +ACTACTAGTAGTCTGTGACTTCATTTTTGGCATTTTTCCGTTTTTCAGCA +ATAATGATTGGTTTTCTTTGTTCTCTAATTTTAAACATATTTCTTCACAA +ATGTCTCAAAAATTAACAACTTCAGTTTAAAGTAATAAAACAAAAAAAAA +AGAAAAATAAAGAAAAACCAGTCAGTTTTTTCAAAAATAATTCAAAAATA +ATTCGGTCCTTATTTTTTTTTTTTTGCAAAAAAAAACAAAACAAACTCCC +CTATAAAAATTTTCCAAAAAAAAATTGGAAGGTTTTTTTTATTTCAGCCT +ATTTTTGGAAGTTGTCGAACTCGATCAAAACATTTTTTCATTGGTTTAAG +TTTTATTATGCTTGAAATATTCAAATTCCAACATACCAGGCATTGAAAAA +TCAGTTTTCGTCGCTTTTTGACTCGAAATAAAAAAAACCAAAAATTTTTG +AAAAGTTTTATTATGATAGAGTCATTCAATTATATTCCCAGTACTTTTAA +ATAATCAAACAATTTTTTAGAATGGCTAGTTTCAAAATCGGCGGCTTTGT +CGTTACATATGAAAACATGCACAACAATATGAAAAATAGGTATGTCTTCA +AAAATATTAAAAACAATATTTTTTTAATTTTACAGATGTTAGCAGTTCGA +CGAAGCAATGCAGGAACTACAGTTATACAATCAAATTCACGCTTTTTATA +TATTAATTTTTAAAATCATAAAAATTACAATTTTCATCAACGTTGATCAG +CTAGACGAATGCATTAAGAAAAGGGAAAACATAGGGCTTCCCAAAACGTC +TGCCTCGCCCGCCTTGTGGCGACCTGCGCCTGCCTCGTGCAGGCCGCGTC +TCCAGTCAGTGCAGTGCAGAAATTTTTATTTCAAAATTGTACAAAAACAT +GGAAAAATAGAGAAGGATAATTTTTTAGGCCTCGGAAATCAATTTTAAGT +CCTCTAGCTACAAAATGAACCATTTTAGAGGAGTTTCAAAATTGTGAATT +TTTACAAAAATTACCCAATTTTGCCACTTTTTAATGGTTTTTGATGGGTT +AAACCTAGATCTTCTGGATAATTCCGCATATATGAATTACCGTATTTCCT +ATATTAGTTTTGCATGCAAGACTAATTTTCAATTGGTCTGTAGGGGTGCA +AGACTAATAGAGACTGCAAGACTATTAGAGGCTGCAAGACTAATTTTCGA +ATGCTATAAAACTCCGAAACGTGACCAATTTTTGATTGTAAACTCAACTT +GATATCGTTTAAACAACAAAAAATACATCCTTTTCCAATATTTAATCAAT +TATTTGAACGCTTTTAATCAAAAACTCGAGTTCAATTTGCCCAGAAATGG +GCCAATTTATTAACGTTGCAGCATCTATGCAAGATATTGCTGGACTGGAA +AAAAGTCGGGTGCAAGACTTTTAGAGACTGCAATACTAATAGAGGCTGCA +AGACTAATTTTCGATTTGCCCGTAGGGGTGCAAGGCTAATAGGGATGCAA +GACTATTAGAGGAAATACGGTACCTGTTTTTGACAAAATTAGACAACTTT +TTATTTTTGCTCAATTTTTTTTCAGCCATCTAATTACTGTCCTTTTTTTT +TGGACAATAAAAATAAATTTTCTAAAAGCGTTTGAAACCACTATATTTTG +CAAAAGGACAATTTTTTAGGGATTGGAGATCAATTTTATGTCCTCTAGCT +ACAAAATAAACAATTTTAGAGGAGTGTCAAAATTGTGAATTTTTACAAAA +ATTGCCCAATTTCGCCACTTTTTATTTTGGTGGGTTATACCTAGATTTTT +TAAATTCAGCATATATGAATTACCCGTTTTCAACAAAATTAGACAACTTT +TGATTTTTGCCCAATTTTTTTTTCAGCCATCTAATGACTGTTCTTTTTTT +GGGCAAAAAAAATAAATTTTTCTGCAAACGTACAAAACCATTAGAAATTG +AAAAAAGGCAATTTTTTAGGGTTCCGATATCAATTTTGAGTCCTCTAACT +TCAAAAATGACTATTTTAGAAGAGTTTCAAAATTGTGATTTTTCTGCCAT +AAATTGCCCATTTTTGCCACTTTTAATGGTTTTTGGTGGGGTATACCTAG +ATTTTCTGAATTCTGCATATATGAATTACCGTTTTCGACAAATTTAGACA +ACTTTTTATTTAAAAAATTAAAAAGGATTAAAGGACGATCCGTTCTTCAA +GTGCTATGCACTGCGGATCTGGGATTCAGGTACACTGCCTGGTGGTGATC +CCTCTGGGCTGTAATTTAAGCCACGTCCTAGCCGAGGACTGTGGCCGATA +ATCCAGTCGTGGATTGCTCCACTTCCCAATAGAGGCAGGGTGAACCTAGG +GGGTGAGGCCGGACTTTTATCTCGTGACCTCCAGACTGCTAGCGGCCACC +ACTACCGACTGAGCTATCTGCCCCCCTTGGGGAAAAAAATAATTTTTTTT +TTTTTTGGGCAAAAAAATAATTTTTTGGAAATTGTACAAACCAAATATTA +TATATTAAAAAATATTATCCAAATATTCCAAATATTCCAAATATTCCAAA +TATTCCAAATTCCAAATATTCCAAATATTCCAAATTTATTCCAAATATTA +TGAAAAAGGCCATTTTGTTAGGGCTGGGAAGTTTGAATTTTTACAAATAT +TGCCCAATTTTGCCGCTTTTTAATGGTTTTTGATGGGTTAAACCTAGATT +TTCTGAATTCTGCATGTATAACTTACTTGTTTTCAACTAATTCAGACAAC +TTTTTATTGTTTTTTTTTCAAATTTTTTCAGCCAATTAATGACTGTCCTT +TTTTGGGCAATTTTTTTTTTGAAACAAAAAAAAATTAAATTAAATTGCCC +AATTTTGCCACTTTTTAATAGTTTTTGATGGGTCCCGGAAACCTAGGAAA +CCTAGTCCCGGAAAATCGAAAAATCGAAAAAAAATTTTTTGAAAATTTAC +CAATGAAAAAAAAAAGACTCAATTTTCTTCCAAAATAAAAAAGTGGGCAA +AATTTTAAATATTTTTCGAAAAAAAAACATAACTTTTCAAAAAATTTTTC +GATTTTCCAACAAAAAAGTGAAATAAGAAGACATGCAGGTTACTGTAGCT +GATAAAGCTTCAAGCGTACCAGGACCCGAAAACCGCCGCCCGCGTAAATC +GACATATTTAATGTACCATCAATTTGATCCTCCTCTTCCTCCTTCTTTCA +ATGACACCACACAACTTCCTGTTATGAAGGTCTCAATTCCCCTTCATAAC +ATTCTTTGTAATTAATGCACCCTAAACAAACTGTGCAAACACACTTAGAC +ACCCCCCTCCTACACGGTCTTTGGAGTTCCCCCGCTCAACTCTAATGGAC +CTGGTAATCCCTTGCGCGGTGGGATTTTTCGGGTCTCGCCGCGATTTTTA +TCCGAATTCCGGAATACCGGAAATGGCGTGGAAATCGATATTGCAACAAA +GAAAACTGTTTTATTTTCAAAAATCCGCTCACTTTTTTTAAAAGTGATCT +TTCAATCATTTTTAAAGTTTTTTTTTTTGAAAGCACGCGTTTCTGGCTTC +CCACATATTTTGGAATGTAAGAGATTGCCGAGTTAGGCCATTTGGACTCG +GCCACGGCCGGGGTCGATTCACGTAGCGGCTCGGTTTCTGTAGAAAACTA +AATGTATTTGTCCGTATGGAGTACACAAGCTTTTCCAGGCGTTATCCGGC +AGGCGATAGAAGCCGCGACGCAACACGCAACGCGCCGTAAGTCTACCCCG +GCCGTGGCTGAGTTATGATGGCCTAACTCGGCAAACTCTTGCATTTGAAA +ATATGAGCGAAGCCAGAAGCAGGTGAACATGGATTTCTGGCTTCCCTCAT +AAATTGAAAAGGGAGAGTTTACCGAACTAGGCCATTTTGGCTCGGCCATA +TCTGGGGCAGATTTACGGCGCGTTGCGTGTCGCGTCGCGGCTCGTTTTTA +GTTGTAAAACTGAATGTATTTGTCCGTGTGGAGCACACGACTTCCCCACG +CGTTGTCCGCTAGGCAATTGTTAATGGAGCGCGAAAAATTCAATGAGGAA +GGCCAGAACCCCGTGTGTGATTTTTGCAACTACAGCCCAAAATTTGAACG +GGATTAATACAAATTTAATTTGAAATTTGGATTTCGCAATTCAAAATTTG +CGAAATTAAAATTTCGAAAACCCGAATCTCATCGAAATTAAATTCCAAAG +TTTTCATTCAAATTTCAATGAGGTCTCTATTGAGCCGAATTCCCGCGCAC +GGGAGGTAGTGGACCCCTTTTGTATGTTTAGGGGTACAAAGACCCCCTAC +CACCCCTTGTATATGCACAATAGAGAACACTCAAGACCCGCCCACCCTAG +GCCCCTCATCCAAAACATATCCGAATATACCCTCTACTGTACTTTATTTA +CTTGCTCCGTTTACCCGGGTACCAGGGTACTCCCTAAACTAACTGAATTT +CCAAGGTGGTGGCCTAGAAAAAGCTCTTCCACTGGTTTTTTTGTGGAAAG +AAATGATGAAGGTTCTTGTTGTTTTATTGCTTATGGTAGGTTTTTTTTGC +CACGTGTCCGGAATTTTTAAAACTATTTTTCTATTTTTTAAAGGCCCAAA +ACTTTGTTTTTTTTAATGTTATCGTTTTTTCGTGAAAAAAATTATTTCAG +AAAACGGGGGTTTTAGGTTTAGGCTAAAGCGTAGGCTTAGGTTTAGGCCT +AGGCTTAGGCTTAGGCTAAGGCTTAGGCTTAGGCGTAGGCTTAGGCATAG +GCGTAGGCTTTAGGTTTAGGCTAAAGCGTAGGCTTAGGTTTAGGCCTAGG +CTTAGGCTTAGGCTAAGGCTTAGGCTTAGGCGTAGGCTTAGGCGTAGGCG +TAGGCTTAGGCCTAGGTGTAGACTTCGGCTCAAACATAAGCTCAGGGGCA +AAAAAAGGAGAAACTCCCACAAATTCCTAAAAATCCTGAAAATTTTTTTA +AATCTTAAAATAGTCAATTTTCAGTGGAAATCACAGTGAGCATTTTGAAA +ATCCAATAATTTTCAGGTAAATTCGACATTTTCGTTCGGATTGGACAATG +AAATAATCGGTGAACCAAAGTTACAATGCAATCCGGAAAGTATTACATTC +TCCTTCAACACACGGAATCCGTTTATGTTAGTCTTGGGGTCTCGACACGA +ATTTTTCCCGCAAAATTAGTTTTCCACGCGTGAGTACACCGCAAGTAGAG +CGCTTATCAATAAATTATAAATTATCAATAGAGCGCACTTGCCCCCGGTG +AATTTCAAAATTTTCAGAGGAAACGTATATATTCGTGGCTTCTACCGAAC +ACCCGGCTGTCGTCGGCAATTCCTCGCACCGAATCAGGCTGGCGGCTCAT +TTACGGTACGGCTCGGCGATTGCGGGATGCGGCGGTCCCGACAAATCAGT +GGACATTCGCCACGTGGCGTCAATCAGCACATCACTTTTGTTGCGAACTT +TCATCCGAATCTCGCGACGAAAGAGGAACGATCATTCAATATTCGATGCT +TTTATGCGCACAGTGAATCTGTTGTCAAAGCTGATCTGGATGTCAGGTAG +GGATGCAAATCGATAAATTCCCCGAAAATCGATACATTTTCCAAAAATCA +ATAAATACCCAAAAAATCAAACAATTCCCAGGAAACTGGAAGAAAATTCT +CAGAAAATCAATAAATGTATTTGTTTTGCAGCTCAATGCCGGAGGAATCG +TTCGAACAGGGTGTGACAATCGTGCCCCAATGCACATATTCCCTTCGTGA +AGGGACATTTGAGGGCCCAAAAGTGTCGAATACACGTGTCGGAATGACAA +TTGTTCATCGATGGGACTGTGATACATCGGGGAACTATGGAATACTGCTA +CGTGGATGCACCATACTCGATTCACGTGGTGTTGAATCTTTTCCATTGCT +TGATGAGAATGGGTAAGAGTAGGGAAGTGTCGGCCGCTAGAAAAGAAAAA +TATATCACTAGAGCACGTTTTCTAAGCATTTTTCTCAATAGAGCGCGCTT +GCTCAATTCCCTAAAATAAATTATGGTGCATCGAAACGTGTTTACGTACT +GATAGAGCTGTAGTACTCGAGGAAGCTGAAAAAAATAATGAAGAAAGTGA +AAAAAATCAAAAGTGTGAACACAGCAGCCTTGTCAGATAAATTTCAAAAA +TCTGTGCATTTGGTCGTAAGTTATGGCGCATCAAAAGTTTTTTGAAATTC +TCAATAGAGCACATTTCAAAAAAGAGCGATTTTCGCAAAGCCCCTTTCTT +CGTTGTTTGATTTAAAAACAATGCAATTTCGTTTATTTCGCAAATTTTTG +AAAAATGAGTTAAATTTGCAACAGAGCGCGATTGCACACACACACACACA +CACATCAAACGTCAGAGACCCCACTGATTTTGGAGATTAAATTACGGTAG +ATAGAGAATCACAAGGAAAACATCACGAACTTTGTTCCGTCAATTCCCGT +GGTGCTTGTTATCATCAGAATGCAAAATTTGAAAGTCTGAAATTAAGCCG +TTTCCGCTAAAACGTAGCGAATCTCATTCCACCGAGTCTATTTTCGTGAG +GTCTCCAATTTTTCAAGTCTCTGCTCGTTATGGTGCATCGAAGGGTAATT +CAAAATTTCAAATAATTTTTAGACACTTTTCGACCAGTTTCAAATTTTTT +TTATGGTGCATCGAAAGAATTTTGCGTAATTTTCAATAGAGCGCGATTAC +TACTCACCTCTAAATTTCTGCAAATTCTTTTTCCAGATGCTCAGTGTCCC +GTGACTTCCCACAAGTGGTATATCTCCCATCACTGACGTCAGCCTACATG +GCAATCGAAGCCATCTCATTTCCTGACCAACCATCGATTTCTTTCTCGTG +TCAAATTAAGTTGTGTGATAAGGGAAGTGATGAGTGTCGGGGTATGAGTC +CCCCCGCGTGTACCCCATTGACACAGGTCCCCATCACGGGACAAGTACCA +ATGCCATTTGATAATACAATTGGAAATACGTTTGGTGAGTTATTTACGGC +CGAGAAAACCTGCAAAAATAAAAGTTCAGCCACCGAACTTTTTGACATTT +TTGCGCAACTGTATGCCGCACAAAACTTTACGTCAGAAGTGGGCGTGTCC +GCCTGCAGGCCCCGATGTTTTAGATGTAAAAAATTAGATGTTTTAGATGT +AAAAAATTGAAATTTGAATACAAAAAAAAATTCGGCCACCGATTTTTTTT +GCTTTCACGTTTTGTCAATGCATTTCCAATTTTTTTCGTGAAACGTTTTT +GTCAGAATTGGGCGTGTCTTGTAAAGTCCCGCCCAATTTATGGGCGTGGC +TTGTTTCGACCAAAAATACTGTTTTTTTAACTCACAAAAACAGAGCTATA +AACTTTTTGAAAAAAACATCCCTGTCCTCTCCTTTCTCCATTCTAAAATT +TGAATTAGATGGCCGTGAAAAACCCCGGCCGCGGTCTTCAATTACAGTGA +AGAATTTGGCGGCAGAGCGCGTTTTCACAGTCTTTTTTTGTCGTCACTGA +GCAAACTTCAACTGCTTCCAGCCAGAAATTTACAAGCAAATTCAAATTTT +CAGACGGAATCCCACTGGAGCCGTGGATGAAAGAGCCCTCTCCTCCCACT +GATGACGTGGCAAACATCACCTCAGAAGGCGAGCCAATGCCTCGGCTCAT +CACCGAAGAGGAACAATATCAAATCGAGTCGAACCATGTTGAGGCGCGAG +AAAAACGATTTGCTCATCGATTATTCAATATCACATCGGAAGATCTCTAT +GTTGAGCCAACCGTCGAGCCAATGGAAGTAGAGATGCCTGGAGCACCGAG +AGAAACTGCTCGGAGGGTGTCTGAGCCATGTGTCTCGGTTGAAACTTTCT +ATATTTCGGCGCTTGCTGTACTTTTCGTTTTTGTCGTTTCGATTGGGATG +GTCTGTTTCTTCGGAAGTCATATGCTTAAAAAGTTGGTTTTTTATTGATT +TTCCTCCCACAGGGTTCTGACCTTCCTCATTGATTTTTTTGCGCTCCATT +GACAATCGCTTGTCGGAAAACGCATGGGAAAGTCGTGTACACGGACAAAT +ACATTTGGTTTTACAACTAAAATCGAGCCGCGCCGCAACACGCAACGCGC +CGTAAACCTACCCCAGCTATGGCCGAGTCAAAATGGCCTAGTTCGGCAAG +CTCTTTCATTTCAAAATATGAGGGAAGCCAGAAATCCATTTCCCCAAATT +GCAAGATATTTGTGGCGTGGCCGAAGTTTTCTAGTTTCTCGGCCACGTTG +TCAAAATTATTTTAAAAAATCGCTGGAAACACTAAATTTAGATATCTCCT +GTAGATTGTGATTCGCGGAAAAATTCCATGAATCTCGTTCTCCCAGTTTT +TTTTTTGTAAATTCAACAAATCAAATGAGCGCCAAAACCTCACAAATCTC +ATACTCCCAAAATTTGCGTTCCTCTTTTTCTTGAGGCCTCCTCTTTTCAC +TGTAAAATTTAAAAAACTCGTAACTTTTTCTTCAGAGCGCGATTGTACGC +ACAGAAAGTCTTTAAAGTCTGAAAATATTTTAAAGTTCCCCAAAATCCCA +CAAGTCTCATTCCACCGAGAGGTCATTTTCCGTGAGGTCTCTTTCTTGGG +TCTCGACGCGAAAATACTGTAATTTTATTAATTTTTTCAGAACTCAAGAC +TGTGAAATGCCGATTCCAGTCCCAGAAGGATATTATCTAAGCAAACACTG +AAACTCTTGTTTAAAAGTATTCGTTTCCCATCCACGTGCCATAATTCTTG +CATTTTCTTTTTTTTTCCCTATTTTTATTCAATTTATTTACAATTTGTTC +AATAAATAATCAATAAATAATAATTAAAAATAACATTAAAAGTCACATTT +TCCGAAGGAACCACGCGTGGAATGTAACGGTGCCGTTGTCGAATGGTTCC +GGCTGAAAATTGATTAGTTATCATTGGAGCGCAATTGCATTTTTCTCGAA +AAATCGATGTTTTCGTGTGATGCAGAATTATCGATTTTTTTTAACTTGGT +GGCCGAGAAAATGGAAAACTCAGTCATCGACTTTTATTTACCTGGAACGA +AAAAATTTAAAGTATGATCACGCGCTAAAGCCTCAATTATGCAAAATGCT +TTAAAAACGGGTTTTGGAATTTTCTAGACCACTGGTGACGTCACTCCTTT +TCCATTTATTATTCTAACTGTTTTCTAGGCCACTGATGTCGATATTTTTC +CACTGCTGGGTTTCTAGATCGCCTGCGACGTCATTTCTCTTCCATACCCT +GCTCTAGCGGGTTTCTAGGCCACTGGAGAAATTATTTTTCTTCCAAAAAA +AAATCTAGGCCATTAATGACGTCATCATTTTTTCTTTTCTTTAGGATTAC +CTCAGGTTCCTCATATTTCAGATCCATCCTCGCCAATCGTTCATTCTCAT +GAACTTTTTCCACTTTTTCACTGCTCGTACTCTTCTCATCTACTGTATCC +GCCACCACAACGTCCGGAGCAACAACTTGCTCATCAATATGCTGATATTC +GGGCTCCTGGCGGTCCCAACGTGGTGTCTCTGGTGCAGTTTCATATTGAT +TTTGCTGCTTCTCCAGGAGGTTCTGTATTGAACTGATCGCTGAGGAGGAT +CCAACGATCGGAGGCATCGGAGGCGGCAGAGGAGCCATAGATGGAGTCTG +AGAAGCCATCATTTGGAGTTGGGGGTAATTCCTTTGTTGGGACATCTGTG +GGGACATTTGTGGGGACATTTGAGGGGACGGGGACATTTGGAATACCATC +GGAGGCATTGGAGGTGGTGGGGGTGCCGGAGCCATTCGTATCATTGGAGC +CATCACGTAAGATGGTGGAGATGGTGGGAGACTGGAATTTTTTTTTTGAA +TTTTTTTTCATAACACGGGCTTCTGGCCTTCCTCATTGCACTTTTCGCGC +TCCGATGATAATCGCCTGCCGGACGACGCGTGGAAAAGTGGTGTACTCCC +CACGGACAAATACATTTAGTTTTCAACTGAAAACCGAGCCGCGACGCGAC +ACGCTACGCTCCGTAAATGGCCTAATTTCTTTTTTTTAATCTTGAGTTAA +AGTTTAATTTTAATTATTTCTACAGAATTGAATGGCTGGGAATGTGCCAC +GTGGCCGAGAATTCTCCTGCGTGGCCTAGAAAATTCAAAAAAATATTTTT +TGGTGGTTTTGATTACAAAATAAAGGATTTATACGGATAAAAACCTATTT +TAAAAGCCGTGAAAAAAATCATATCAACCACTGCCTAAAAGATTGAAATT +TTTATGATGGCCGAGAATTCTCAAGTGTGGCCTAGGAAAAATCAAGGCTT +TTGAAAATTTGCTCATTTCGAAAATTAAAAAAAACAACTCAATTGATAGT +AAATTTTAAAATTAAAAATTATTTTTCTGGTTTTTTTTTCTCAATTTTTG +CAAAATCAAAATTATAATCAATTTTTAATCCAGAATTCGTCAAGTGGCCT +AGAATTCTACTGCGTGGCCTAGAAAATTCCACCAAAATTTAAATTTTCCA +AATTGTAAAAATGCTCCAAAAAGTTGAATGGTGGCCGAGGTTTTTCGTTT +TTCACTTTTCACAGCTACGGAAAAAAACTCGGCCACCAATAGTTTTTCCT +AGGCCATGTTTCAAATGCCCTATTTCTATGTTAATTACAGTATTTTCTAG +ACAAGATTTTAAAAAAACTCACGAATAGCACATGGAGCTCTGACACTTGC +TCCCACCAATACAAAATTCCGAATTTTTTACAAAAAACTGCAAAACTATA +AGAATTTGTGGTAGAAATTGGGGCATTTACGTAATAATAATAATAGAAAA +ATGTCCGCAAATTTTTTTTCATAAATTTCATAGGGAGGAGGTAAGCTTCA +GCTAGAAGCCATTCAATTTTATTGGGGCGCCGAAAATCTTCGGAACACTT +TTACAATTTATACAGTAGTGTACAACTTTTACAACTTAATAATATCTTCA +ATACTTCCAGAATATTCTTCTTTTTCCTCCTCAATTGCCACGTCATCATC +TTGTAATCTGGTCCATTTTGCTGGCGAGGCGTCGGCAAACAGGCAGAATA +TAGTATTTACGAAGAGAAGTAAGCCCGCATGCGCCAGGAAACAATTACGC +CAGTCTGTGAATCTGAAAAAAATAATCTTGTCTTTTAGGGGACCTACGCC +TGCCTGCCTACGTCTGCCTTGCAGGGGACCTTTGCCTACCTACTTGACTA +CCTTCAAGTGAGACCTATGCTGGTTTGCCTGCATTTTTGTCAGTGCCTTC +TAGGCCTATGCCTACCTTACAAACTATGTAGGTCAACTGCCTGCTTTCAA +GGTGGCCTAGGTCAGCCTACATGCTATCTACGTCTACCCCAATGTACCCT +GTGCCTATCTACCTGCTTTTAATGCTATCTGCCTTTTCGATAGTCTTTTA +GGGAATCTACGCCGGTCCAGCTCACATAGGTTATCTATGCCTATGCCTTC +CTGCCTGCCTCCAAAGTGACCTACGCTTACCGTGTTTTTTTTTCTAGACC +GTATATACCTACATGCCTGCCTTTAAGTTTACCTATGCCTGCCTGCATTC +CTCATGCCTGCGTGCCTACATGAATACCCTAAAAACTCACGTATCATCAG +TAACAATCATATTGACGAAAAACGGTTCGATGAATATCGTGCAAGCCCAG +ATGTTCATGATCTGGAAGAGAAATCGTTGGCCTAAAAATTTTCTCGGCCA +CCCCCTTACCTGCTGCATTGCGAAATAGGCGTACTGCTGGGAGTGCAACG +TGGCACACTTGTTGAATCCCGCCGTATTGCACCCCATCACACTTTCGGCG +CAAATCTGGAATGATGGAAGAGAATAGGAAAACTAGGCCATGGATGTATG +TGCGCTATGTTGATAATCGGTTATTTTCAACGTGGATTATCAATTGAGCG +CACTTGTCCCACTGGAAGAGTTTTCCTATCTAGGCCACCACCACCACCCA +CTCACCATTATAATAATAGCCAGCAAGTGTTTTTCCTGTGGAATAAATGC +TAGAACGATGAAAAAAACGGCGGCCACGGCCAGAGCGATTGTGTTGAAAA +TTTTAGTTTTCAGAGTTTCTGAGATGAATCTGGAATATTGATTTTTGGTG +GCCGTAGAGAGGAAAAACTCGGCCACTGATTTTTTTCACAATTATAAAAT +TATTTTTCCAGGAAAAACCCCCGAAAAACTCACTTAATATAATCACTAAT +AATTCCCGACGATAATTTCGTAAAAAATTGAAAAATAATGGGTAAGGCGG +CCAAAAAACCGGACGAAAGTACGTCATAGTTCAAATAATTTTTCATATAT +TGCGGATTGAATTGGGATACCAATTGAACTGTTATCAAATCTCCAAACGA +TGCGATCCAACAAGCCCACAGGCTTAAACTTGTCAGAATATGACGGAATG +GAAGATTTTTTGGCCGGGATACCTGCAAAACGAAAAAGTAACGGGCTTCG +AATTTCCCCCCCCATGTTTTCAAATGGAAGAGGTGGCCGTGAATAAAGCT +AACCTCGACCGGGGGTCGCGACTCGCGACAAACGGGAAAACTCAAAGAAA +TTTCGTACTGTCGCTACTTTTTTTGAGTTTTCCTGTTTGTCGCAGGTCGC +GACCCCCGGTCGAGGTTCGCTTTTTTCACGGCCACCTCTTCCATTTGAAA +ACATGGGGGAAATTCGAAGCCCGTGAAAAGTTAGGCCATGCAATGCGATG +TGGTGGCCGAGGTTTTGAAAACTCGGTTACTCTCATGTAAAAAATCTTGA +AGTTGAAGCAAATTTGCGTACATGAAACCCATTTACCTTGCTAGCAGTTT +TAGAAAAATTTGGGATTTTCTCATACTAATGAGGGAACGTCTTAATTGTC +GACAAATTGCGTACCCCGAGGAACCCACTAATTCAGTCCTAGGTTTAGGC +ATAGGCTAAGGCATAGGCTTAGGCGTAGGCCTAGGCTTAGGCTTAGGCTT +ACACGTGGTGTCAGAGTGCCTCATTTCGGCTTGATCTACGTAGATCTACA +AAAAATGCGGGGGAAGAGCCGCAGAGTTTTCTACTGATTTCGCATGGTTA +AGAGTGTGCTGACGTCACATTTTTTGGGGCAAAAATTCCCGCATTTTTGG +TAGATCAAACCGTAATAGCACAGCCAGGCACCACGTGCGCTTAGGCTTGG +GCTTTCCGTAGTCCTTCGGGCGCGTTTTTCTCAAAAATGATACGTGGTAC +AATTTCAGGTTTTTTTCCGCTCCAAAATCTAGTTATAATTTGTGTCCGGT +AGAGCGCGTTTGCACTCACTTTCTTTCCCGATTTCCCTTCTCGAATCCTC +TCCAATTCCTTCTCGCCAACCCAACTGTGCTCACTCGGCGAGCACTTGAA +AAATAGGAAAAACAGCGAAAAAGTGACCAACGATACACCGGCGTGCACAT +AGTAAACCGACGTCCATCCACCAGACGAAGAGCATAACCATCCCGAAACT +GGCATTGTAAATATATTTGAAAGTTGTGTATTTCCGGTTAATAGGCCAAT +GAATACTCCGTGCTCGTATGGGGTCGCCCAATTTGCTGTAATTGAGCCAG +CGAGGGGAAATGTGGCTGAAAATGCCATTCCTTGACAAATACGGGCGGCC +ACAAACCATCCGTAGCCAATGGTACTTGCCAACGGGATAAGGGCTGTTGA +AACTGGAAAAATTGAGTGCAATACATCATATTTGACGCGCAATTTTAAAA +TTTAAAAAATGGAAACGCGCTCTAATGATGCTTGGTGTACTCCTCTCGGA +CAATAAATGTCAATAATTTTTGAAAAATCGATAATTTTTTTTTAATTTCA +GAAAAATTCGTGAAATCTGTTTTATTTTGCGCGTAAAATATGATTCTTAA +ATACTTAATTCAGTATTTTACGCACGTGGTATCAGAGTGTCTCATTTAGG +CTTGATCTACGTAGATCTACAAAAAATGCGGGAGAAGAGACGCAGAGTTC +TCAACTGATTTCGTATGGTTAAGAACGTGCTGACGTCACATATTTTCGGG +CAAATAATTCCCGCATTTTTTGTAGATCAAACCGTGATGGGACAGCCTGA +CACCACGTGCTTACGCGGAATTTTTCACAATTTTTTGTGCTTCATGCACC +ATGTTTTTGTTTCGAAAAATCAGATTATTGTTTTGCGCGTCAAATTCAAC +GCCCACTGTGCAATACACCATATTTGACGATCAATTTCAAAAATTTTGTA +TGCTTTCGATGCATGCTTTTTGGGGTACTGTAGCTTTGAAAATACGCATG +CACTGGATCTGACGACAAAATGCACAGTTTTTATAAAATTAGTCTATAGA +AATTAGTCAGTTTTCTCGAAACAAATAAAAACTACAGAAAACTCGGCCAC +CGATATTTTTTTTTTTCGCGGCCACGATTGACGTCATACCTCCCGAAATA +ATTCCGGCGACAATGAAGACAGGTTTATGCGGCAAATGTTGAAAAGAAAT +GGAAAATGGAATCGAGGCGGCAAGACTTCCAATAGCCACACACGATTGAA +GAAAATTCGACTCTGATTTGGTATAGTTCACTGAAAAAATCAACTATTTT +GGCGGCCGCCAATGGAAAAACTCGGCCACCGAATTAAAAAAAAAACCTTT +TGAAGTTGAAGTACTATTATCATCTTGCATACAAATTTTTGTAAAATTAT +AAGTATTCATATTTGAAAGAATCGAGGTCAAACACAGTGTGGCACATATT +AAAATCTGCAAAAAAATCGTGAAAATTCAATTTTCCGGGGGTTTTGAGTT +CAAAAAGTACCAGAAATCGGACAGGAACCGGCGAGTTGACCATGGTGCAT +CAGAAACCGGAATTTTAAATAAGTAAAAAAATTTATGATGCTCGTGGTGA +TAACGAAAAGTGCAGTGATCAATTTAAGGGAAATACTGCTGGGGGATTAA +ACGTTGACACTGTCAACTTGATAGTGTTAATTTGATCAATGCTTTGTACT +TGTTTTTTGCAGGAAAAATTCTTTGAAAATTGCAAGACTATAGTATAGTC +TGAAAATTTGATGAAATCTAAAACTTTAATAAATACCGTTAATTATCATT +ATTTTTATGAAATTTTAATATAATCTACTTAAAATTTAATTTTCTAGGCA +TCTGTGAGCTTAAATTTTCGATTATCCCTCGCCAAATTAAAGATTTGCAG +ACTTTTAAGCTTATAAGCTTATTTCAGTGAGAGAGAGCATTGTGAGAAGA +GAAACGCAGACGAGGCTGGCGCGTTTCTCGTGCTCTGACGCGAGTCTCGA +TTTGCTTGCGCATTTCTCGTGCGCGCGACGTTCATTTTATTTTTCCGATT +TTTTTTCAGTTTTTCTGAACTTTTCTTCTTGAATTTGTGATTTTTTATTT +ATTTTTCACGTCTTGTTGCAAAATAACTGATTTTTCACACAAAATATTCG +AATTTTCAGGTCGGCAACATGGGATTCTTGTGGAAAACTGCAAAACTCGG +AATTAAAGTTGGACTCGTCGCCGGCGCCGTCAAACTGTCAATCGATAACG +ATATTTGGTCGACTAACAATGTTAAAGTATTAGTTTTCCCCCGTTTTTCC +ACGAAAATTTTCATTTTCAGGGCAGCGAACTGTATCAAAAGCTTAAAAAG +TACATTCTTCCCGGCACCGTCGTCTTTCCAGAGCAGGTTTTATCGATTTT +TTCTCTGAAAATGCAATTTTTTTCTTATTTTCAGCTCCCAACAGTCGAAG +ATGTGCAGCTGAAGGCCGGTGGAAAGTGGAACAGTGCTGTTGACTCGGTA +GGCTGCATTTTTGAGAGGAAACACGGAAAAATTGCTGCGAAAGTTGGAAA +AAAGTCCTGGAAAATGGAGATTTGGCGCCGAACGTTCAAGAAATTCCATA +ATTTCAAAAATCTATCTGAAAAATTGAAAAATATAAATTTTCAGTCATTT +TTAGTCAAATTTCAGAGCTAAACGTCGAAAAAAGTGCCTAAAACTAGGAA +AAATATGACAAAAAGACACAAATTTTGGAGAAAATTGCTGAAAATAATGC +AAAACACTTTTTTTCACAAAAAGCGAAATTCAAAAAAAATTCCACGTCAA +AAATTAACCAAATGCAAGTACGCTCCATCGCACTTTTTTCCAATTTCTGA +CTCGAAAAGTCTTAAACTTCTGGTTTTGTAGGAAAGATAATGCAAAACGC +AATTTTTAGTCCAAAATTCAGAGAAAATTCTGAAATTGTTTTTAAAAAAA +ATGCAAGCACACTCCATGGCACTTTTTTTTCAAAATTTCGCGTAGAAAAT +TACAGACATTAGCAAAATTCCGACGATTTCGCTGCGAGACCAGAAATATT +GTAGGAAATTCAAACATTATCCGAAAATAATGCAAACGCGCTCTATCGCA +CTTTTCTCCAAGTTCCCACTCAAAAAGCATAGAAAATACCTGAAATTGCC +GTTTTTTTTCACCGGAATTTCAAATTTACGCGATTTCGCTGCGAGACCCA +AGCTAGTGCAGTGGAGCGCATTTCCAACAATTTCAAACTCAATTTTTTTC +AGGTATTCACCACAATCGAGAACGTCCCATCAAGCGTGAACACAGTGGCC +AATCGACTCATCAATAATAAATAAATTCCCCATAAAAATTATCGATTTAT +CGATTTTCCCCCCGAATCCTCGTGTATTCCTTCGTTAGAATGTACTTTTT +CCCTCCTCATTTTCTAGAAGTATTTGTGTGTGTGCTCTATGAAAAAATTT +GCAATTTTTGACTTTAAACGGACGGTGCATTATATTATTTTATCAGTTCC +CATCGTTGATCAATTTTCTCCACTGATTATCAATTCACTGATAAGCTCAC +ACTGCCTGCCCAACTCAATTCATCGCAACTTCTTCTCCCTGCTTTTTTTT +GCCATGAATTCGACGGTGGCTTCCCGTTTCTCATGGGGACTCATTCTGGC +GTCGATCGATTTTTTGGCGTGCCTACTGTTCGCCTGCCTGCATGATGGAA +CTTTCAAATTCGCGAATTTTACTTCGCAATTTGGCGATTTTTCGTTTTTT +ACGAGGTTCGATTGATTGGTGGCCGAGTTAATTTTAGGCCACGAAAAATG +AAAATTGAAGCCGAGTGTCATTTTCGCTGGAATTCTAATTTTCAGTGTGT +AAAAATATAGAAAACTGCAAAAAATTTTGAATTCCCGCCAAAAACTAACG +TTACGAGACCCAAGTACAGTGGAGCGCAGTTGCAAAAAAAAATTTTTAAT +GATTTTTTGCAACTACGCTCCACAGTCCTTGGGTCTCACAACGTTGAAAC +TAAAATTTTGGAATTTCTCCCATAACTTCTTATAATAACGATATTCGGTG +GTCTCGACACGACATATTTTCATTAAATAAAACGGGTGTGCGCCTTTAAA +GAGTACTGCAGTTTCAAACTTTAGTTGCTAAGCGTATTTTCAACAAAGCA +ACGAAAATTTGAACTTACAGTACTCTTTAAAGGCGCACGCCCGTTTTTAT +TAAAACAAAAACTTGTCGTGTCGAGACCGGGCACCGTAGTTTTGACGCTA +AAAATAAGATTTATGAAAAAGCGGGTTTCCAGAAAATTTCACTTTTCAAA +CTTTGATGAAAATTTGAAGTTTCCAGCCAAAATCGCTGCGAGACAGTGGA +ACGAGTGCAGTAGAGCGAAATTGCTGTAAAATTTTGAAAAAAAAGTGAGA +AATTTAAAAACACGGATTTCTGGCCTCCCCCGTAAATTGAAATGGAAGAG +TTTGCCGAACTAGGCCACTTTGGCTCGCCCATATCTGGGGTAGATTTACG +GCGCGTTGCGTGTCGCGACGCGATTTTAGTTGGAAAACTAAATGTTTTTG +CCCGTGTGGAGTACACGACTTTCCCACGTGTTGTCCTCTAGGTGATTGTC +AATGGAGCGCAAAAAATCCAATGAGGAAGGCCAGAACCCCGTGAAAAAGT +ACGCGTTTTTGAAGCAATTCATCGAAAGAAGACAGTAAAAAAAAAGTCAA +AAATTCAAATTTCCAATAGAAAAACCACCAAACCCAACAATTTTTCCAGC +ACAATCGACCTATTCTTGCTGCAATTTTTCCGTTTTGCACTATGGATGGT +GCCGGCGGCAATCCACGTGGCCAACAAGGCGGACACGTTGACAATGTGGA +AAGAGGTCGGTGGCCGCGTGGCCTAGAAATCCCGAAAATTTCAAATTTTC +AGCCAATTTTCTGCTCGGCACTGCTCATCTGCGCGGCGAGCCCCACAAAA +TTGCTCCTCCTCACAGAAAAGCTGAAGCCCGATGAGTTCCTCACTTTCGG +CGACACTGCCTTCCTTGTCTGGAATTTCATTTCCGCGATCATTTTGAACT +CCTCGTGGACAAGATACTTCTCGCGAACTCCGTCTTCATATATAATTCTG +GAGGATGAGGATGTAAGTGCGCTCCGCTGAGAAAATGTTTTGATCACCCC +CACGATTTTCAGCTCGAGGTGGCTCCAAAACAAACGTTTGAGCTTATTTT +CCGCCTGCTCCAATACTGCAAACGTGAATGGCTCTGGCATATTTCCGGAT +TCTCGTGGCTCTTTATTTATTCGATCAGTAAGAGAATATCCATCGGGGGT +TTTTTGTTTCGAATTTAAAAAAAAACACAAGTGGAAGAGTTTTTAAGATT +TCTAGGCCACGCACCCACTCCAAAACCCCAATTTTCAGCCCGTATCTTCG +TTCCCTATTACACGGGACAAGTCATCGCTACCGTGGTCGCCACAAAATCG +TACCCAGCCCTCTCCAACGCTGTCTACATCATGACAATCATCTCGTTGGT +GAGCGCTGTCGCCGCCGGATTCCGTGGAGGATCCTTCGAGTACGCCTACG +CAAGGATCCAGAGGGCAATCCGCTACGATTTGTTCCACGGACTCGTGAAA +CAGGATGTCGCTTTCTATGATGCTCACAAGACCGGAGAGGTGACTTCTCG +TCTGGCTGCTGATTGTCAGACTATGTCGGATACAGTTGCGTTGAATGTTA +ACGTTTTCCTCAGGTAGGTGTGGGTCCGTGACCGAAGTTCCCAGATCACA +TGACCTAATTTTCCCAAATTCTTCCAGAAACTGCGTTATGCTCCTTGGAT +CGATGATCTTCATGATGAAGCTTTCGTGGCGCCTCTCCCTCGTCACATTC +ATCCTCGTCCCAATTATCTTCGTCGCCTCCAAAATCTTCGGAACATATTA +TGATGTAAGTGCGCTCCAGCGAAAACGTTTTTCTAAAGTTTTGACCCCAA +AATTCTGTCAAAGTGCCCCATTTTGGTTTGATCTTCGGAAAATGCGGGAG +AAGAGGCGCAGGCTTTGCAACTGATATCACATGGTTAAGATTGTGCTGAC +GGCACATGGAAAAATTCCCACATTTTTTTGTAGATCAAACCGCACCTGAC +ACCACGTGAAATTTTTGACAAGTCAAGAAAAATTTCGGCAATTGTGAAAT +AATCGAATTACCGCCGCACGTGGTGCCAGGCTGTCCCATTACGGCTTGAT +CTACAAAAAGTGCGGGATGTTTTTGCCCAACAAATTTGACGTCAGCACGT +TCTTAGTCATGCGAAATTAGTTGAGAACTCTGCGTCTCTTCTCCCTCATT +TCTTGTTGTTCTACGTAGATCAAGTCGAAATGACCCACTCTGACATCACG +TGCCGCCTCCCACCCCTGCTCCGACCAGGAATCAGCGGATCTACTTAGTC +TCAACTTGTTTTATTTCAGCTCCTCTCCGAAAGAACACAGGACACAATTG +CCGAGTCCAATGACGTTGCCGAGGAAGTTCTCTCCACAATGCGTACAGTC +CGATCCTTTTCCTGCGAGAACGTCGAAGCCGATCGCTTCTACGGGAAGCT +CACCCACACACTTGATGTCACCAGAACCAAGGCGATCGCCTATATCGGAT +TCCTCTGGGTCTCCGAACTTTTCCAGTCGTTCATCATTGTGTCAGTCCTC +TGGTATGGAGGCCATCTAGTGCTCACCCAGAAAATGAAGGGAGATCTTCT +AGTGTCATTTTTGTTGTATCAAATGCAACTCGGAGATAATCTTCGTCAAA +TGGGAGAAGTCTGGACAGGATTGATGCAATCTGTTGGAGCAAGTCGTAAA +GTGTTCGAGTACATTGATCGAGAGCCCCAGATTCAGCACAACGGGGAGTA +TATGCCGGAGAATGTTGTTGGAAAGATCGAGTTCAGAAATGTTCACTTCA +GTTATCCAACTCGTTCCGATCAGCCAATCCTTAAGGATCTCTCGTTTACC +GTTGAACCAGGAGAGACTGTCGCATTGGTTGGACCATCTGGCTCTGGAAA +GTCTTCGTGCATTTCTTTGCTTGAGAACTTCTACGTCCCGAATGCTGGAC +AGGTTTTGGTGGATGGAGTTCCGTTGGAAGAATTCGAGCATCATTATATT +CATAAGAAGGTACGTTGGCGTCAATTTCGGTTCGACAAATCGTTTGCCGG +TTTGCCGGCAATTTTAATTTTTGGCAAATTGCCGATTTGCCGGAAGTGTT +TAGAGTGCTTTTTTATAAGACGGAAACACTTGAAACTGTGTCCGTTTTTA +AATTTTTGTGCCGGTTGGCGATTTGCATGATATTTTCAATTCCGGCAATT +TGCCGATTTGCCGGAAATTTTCCATTATGGCAAGTTGCCGATATGCCGGA +AATTTTGATTTCGAAAAATTGCCGATATGCCGGAAGTTTCAATTCCGGCA +ACTCGCCGATTTGCCGGAAATTTCAATTCCGGTAATTTGCCGATTGGCAG +GAACAAATCGTTTGCTCGCAGTCTATTCGGATAAAAATTGCGCCAACTGT +TCATCCGTTTGCACAGAAAAAGCATTTCCGCGCTTCGCTATTGGCCAATT +TCAAAATAGTGGGCGTGACCAACCAATCACGGGTGTTTCTTGCTTTCCAT +TGCTGAAACTGTGATTGGTTGGTCACGCCCAATTTTTTGAAATTGACCAA +TTGCGAAGCGATGACTTTGGACGCAAGAAACTTCCGTTTTCTCCTTTAGC +TGTCGATCGAGATTCTCTCCTTTAAAAACACATTGCCGATCTTTTCAAAG +CCCCTGTTTCAAACGACACAGCTAGTAACAACAAAAAACCTCGAAAACTT +CCAATTTTTCAGATCGCCCTTGTCGGCCAGGAGCCCGTCCTGTTCGCTCG +TTCTGTGATGGAAAATGTCAGATACGGTGTCGAAGTGGCGGATACGGTAA +GCACGATTAAATGCACCATGAGCCAAACAAAAAAACTTGTTCAGGAAATC +ATTCGCTCTTGTGAAATGGCGAATGCTCACGGATTCATTATGCAAACCAC +GTTGAAATACGAAACAAACGTCGGAGAGAAGGGAACACAAATGTCCGGTG +GTCAGAAGCAACGTATCGCAATTGCTCGTGCTCTTGTTCGTGAGCCAGCG +ATTCTCTTGTTGGATGAAGCCACGTCGGCGTTGGACACCGAGTCCGAACA +TCTTGTTCAGGAAGCGATTTATAAGAATTTGGATGGAAAGAGTGTCATTT +TGATTGCACATCGATTATCGACTGTTGAGAAGGCTGATAAGATTGTGGTT +ATTAATAAGGTGAGTTGCAATTGCGCTCGACCGAGATTTGGTCGCAAACC +TGACACGGGGTTCTGGCCTTCCTCATTGAAATTTCCGCGCTCTATTGACA +ATCGCCTGCCGGACAACGCGTGGGAAAGTCGTGTACTCCACACGGACAAA +TACATTTAGTTTTACAACTAAAATCGAACCGCGACGCGACACGCAACGCG +CCGTAAATCTACCCCAGATATGACAGAGCCAAAATGGCCTAGTTCAGCAA +AAACTCTTCCATTTCAATTTATGAGGGAATCCAGAAATCCGTGCGCCCGT +GGTGTATTACTCGTGGATAACTGCTCATATTTCAGAATTGAGAATTTCGC +TAAAAACTGTAGAATCGCGTTAAAAATGAGACCTCACCAAAACAGGATTC +ACGAAACAAGAATTCACAGAAATAGTATTCAGTGGGCGCAGTGTGCGCAG +TGTGCGCGGGGGTTGCGAAAGCACACTTTTCGGTCCCGCCCCCTAAATCG +TGTTTTTCGTGAATACTGAATCTGGGAAATTTGAAAACTCGGCGAGTTTT +TCTGTGCGGCACACCCACGTGGTGTCAGGCTGTCTCATGGCCCGACAAAG +GGTACATCAGTGTAAATGCGCTCTACCGAACAGAACGCATAACCCACGTG +GTGCCAGGCTGTCCCATTACGGCTTGATCTACAAAAAGTGCGGGATGTTT +TTGCCCAACAAATTTGACGTCAGCACGTTCTTAGTCATGCGAAATCAGTT +GAGAACTCTATGTCTCTTCTCCCGCATTTTTTGTTGATCTACGTAGATCA +AGCCAAAATGAGACACTCTGACATCACGTGATAACCTGGTTGATACTACG +CGTACGGCTTGCCGGGCCGTGTTTCTCATTGCGGTTTGATCTACAAAAAT +GCGGGAATTTTTCCCCCAGGAAAGTGTGACGTCAGCACACTCAGTCTGCG +TCTCTTCTCCCGCATTTTTCGAAGATCAAACCAAAATGAGACATTTTGAC +ACCAACACACACACACACACACACACACACACACACACACACACACACAC +ACACACACACACACACACACACACACACACACACACACACACATCATATT +TGACGAGCAAAATCGGCCCCATAATTACAGGGAAGAGTCGAACAAATCGG +AAATCACGAAACCCTACTGAAGGACACCAACGGAACCTACGCGAAGCTCG +TTCAACGCCAAATGATGGGAGATCAGAAGCCACGTAAACGGCCGGCGGTC +GCCAGATCGGGACCTCAGCCAGCCGCGTCAATCAACGTGGCAGGACCATC +GCAGGGTAATGCAATGTCCCTGTTGTCGACGTCTTTCAGCCAATCTGCCA +GTAGTGTTACTTCTCATTAATTGTTTTTTCTTCTTGTTAATTGGCAAAAT +ATTATGATGAACTTGTTGGGTTGATTAATTTGTAAGAATAAAGTATACAA +TTATTCATTCATTATTAAAATTTGGGCACATAGAAAAAATTGTGGAAAAA +CTGTAAAAAATCTGCAAAAACGTGGAAATTATTCAAATCAACTCCAGGTA +GTCGTTGTCGACATCGTCTCGCTGCCGCATCGTGTTCTGAAAATCCATTT +TTCACTTTTTTTAAAGCAGATTCCCAGCTAACCGTCGACCGGATCGTGTT +GTTCCATCCGCGGATTTGAGAGTAGGAGCTTACGGTGCCACGTGTCTCGT +TGGCAGCTTGCCAATTATTCACAGACAGCCTGTACGAGTCGCTCAACAGT +GGACCGGCGTTTAGAGTCTGAAAATATATAACGGGAACACTAAAATTTTA +GAATGCGTATTGTGCAACACATTTGACGCGCAAAATATCCAGTAGCGAAA +ACTACAGTAATCCTTTAAGTGACTGCTGCACGTGGTGCCCAGCAGGGCTG +GGAATTTTTTGGTTTTTTGGTTTTTTTGGTTTTTTGGGACCAAAAATCCA +AAAAATCAAAAAAAAAAACAAGTTACCGTGTCTAGTCTCGACTCGAGACT +ATTCTGTATTAAAATACATCGAAACATGTATTTTAACACAGTTGTGACGT +CATAATGTAATACATTTGGCAACATTACTTGAATAACCCCATTAAAAATC +ACCTAAAGCATAAAACATTTTTTGGTTTTTTTTTGGTTTTTTTGGTTTTT +CCAAAATTTCAATTTTTTTGTTTTTTGGTTTTTTTGGTTTTTCAAAAACT +TCAAATTTTTGTTTTTTGGTTTTTTGGTCCAAAATTTTTTTTTGGTCCCA +GCCCTGGTGCCCAGCTGTCCCATTACGGTTTGATCTACAAAAAATGCGGA +AATTTTTTGCCCGAAAACATGTGACGTCAGCACGTTTTTAACCATGCAAA +ATCCATGCTTCTCCCGTATTGTTTGTAGATCAACGTAGATCAAGCCGAAA +TGAGACACACTGTGACCGCGTGCTACTGTAGTGCTCGTGTCGATTTACGG +GATCAATTTTCGAAATGATTATACATATAATTATCGATAGAATAATAAAA +TTAAGCAAAAAAAAATCGGAAAATAATACGAAAAAACAAAGGAAAATTGA +AAATCGCTGTCAAAATTCGAAAAAAATTAATTTCGAAAATTGAGTTCCCG +TAAATCGACACAAGCGCTACAGTAGTCATTTAAAAAGGATTACTGTAGTT +TTCGCTACGAGATATTTTGCGCGTCAAATATGTTGCGCAATACGCATTCT +CAAAATTTTGAACTCTCCGCCTCTCACAGCTGGGTCTCGTTAGGTATGGG +GGCGGATCCTTTTCAATTGGCGGTGGAGCGCGATTGAAAAAATTTTCGAT +TTTTTTTCGATTTTTCAGAAAAAATATCGATTTTTTCCGATTTTTCAGAA +AAAAAATTCGATTTTTTTTTGATTTTTCACAAAAATTATCGATTTTTTAG +ATTTTTCAGAAAAAATATCGATTTTTTTTTCAGATTTTCAGAAATTATTT +TGATTTTTTTTTAATGTTTTGTCCCTTTTTCTGAAATTCTACCTCATAAT +GATTGCTTCTTCCACTTCCGCCTCGCTGCCCGTAGTTCAGTGTCGAGTAA +TTCGCATTCGATACTGTGTAAATCGACAGTGGAATAACCGGGTAGATCAT +AATGTAGTACAATGTGGCAAAGTGGATCACTAACTGAAAATTATTGGATT +TTTCTAATAATAAGGTGGGGAAATCCGAAATATGTGAAAAATATTTTTAA +TAAACAAATTTTCCCCTGATTCCGAATATCTATATGAAAAAATTCAAAAA +AAAATTTTCCAGATTTTATATTTAAGCTTGAAATCGCTTGAGCCCGCATC +ACTATTTTCAAATGCTTGCCCAAAGAAATTTGCATTAGAGCGCGCTTGCA +TAGTTTGATTTTCTTCATTCAAATATTGTATTTATTACCGCCAAATTCAA +TTTTTTAACCGGTTTCATTCATTTTTGTCGAAAAAATATATTTTTCAGAA +AAAAACCGGTGAAAAAAAACCAAAATCGACAAAAACTAATGAAGCTGGCT +GATAAAAATTGAATTCGGCGAAAATAAATAAAATATTTAAATGAAGAAAA +TTCTTAGGCGCAAACGAAATTCGCCATTTCAAGCTTAAATATAAAATCAG +GGATTTTTTATTTATTTTTTTTTCACATTGATTTTCGAAATCAGGGAAAA +ATTTGGGGTTAATTATAAATATTTCCCAGATTTCGGTAAGAAAAATATGA +TTATTTTTTTACTAAAAAATAACCCCCACCAGTAAAGCGTAGAAAATTGA +GATGATAAATGCGAAAATGATGAACGCGGAAGAAAAAAAGTCGGGATTCT +TTTGGGCAGTGCTGGAGTAGTTGAAGATCGAGATGATTGTAGAATAGTAG +GACAGGAATGAAACAATCATCTGTAATTTATTTTTTTAAAGCTTCCAGGT +CAATACACGTGGTGTCAGAGTGTCTCATTTCGGTTTGATCTACTGTGTAG +ATCTACAAAAAATGCGGGAGAAGAGACGCAGAGTTCTCAACTGATTTCGC +ATGGTTAAGAACGTGCTGACGTCACATTTTACTGGGAGAAAAATTTCCGC +ATTTTTTGTAGATCAAGCTGTGATGGGACAGCCTGGCACCATGTGGGTGC +CGAGGGTATTGCTTTTTGGTATTTTTTGGAATTTCGAAAAAAACTTTCCG +ATTTTTTTGAAAATAGCTCTTTTTATAGAAGAAAATAGTTTTTTCTCATC +AACACAAATTTTAGAACAATTTTTTCGATTATCCGGAAAATTGAAAACTT +TCGTTTTTCTATGTTCCATTTTCGATTTTATAAATTTGGGAAAACCTAAA +ATTTCGATTTTTTTTGAAAAAAAAACGAGTATTCAATAATTTATATATTA +TAGGCATTCTTTTTCTCTAATTTCTTCTGAAAAACATTAAAAAAAAATTT +TTTTTTTTTTAAACCAATTTTCAGTAATTTTTTTCTGTAAAAAATACGAT +TTTTTTCCAATAAATTTCTAGTTTTTTCTCTCTTTTCGTACATTTGGACT +GTTTCTAATTTTTGCTTGCTTTTTTCTATATTTTTTCTGCGATTTCCTAT +GAAAAGTACCAAAAAATCGGAAATTGTTTTTTTTTTTCGATTTTTTAGGA +AAAAAAACGATATTTCCTATAAATGTTTTTTTCATAAGTAAATACTTTTC +TCCTTTTCCTTTTGATCTACAATATTTCGAATTTATTTTGAAAAAAATTT +TTTAAACGTTTTTTTCTGAAACAAAGACCCAAATTTTCAATAATTCAATA +ATTTTTCTGGATTGTTCAACCGAAATATACACATTTTTCAATAAATTTAT +AGTGTTCTCCTCTATTTTTGTTGATTTTTACTACTATAATTTTTTCAAAA +TTTTCGAAAAAAAAAATTTTTTTTTTGGAAAATTTTAATTTCAATTCGAT +TTAAAAAATATAAATGTTCATATTTTTTCATCGAAATATATATTTTTTGA +TTTTTCAACCTTTAAATTGTTTCATTTTCTCTGAAAAAATCGGAAAAATC +AACAGAAAAATCGAATTTTTTAAAAATATTTTCCGATTCCGACCGTAATT +TTTATGAAAAAAAATCGGTTTTCTCGTTATTTTCTACAACAAAACCTCAA +AAAACATGCTGGGCAACGTCAAAATCGCTCGATATCGAATCTTCAGCTCA +GTCTCATGTTTCACCAAATACACCGCATACAGAAACATCGTGCAGCTGAT +GAAGAAGAAAATGAGCAGATATGCACACTTTTCCACGAAAAATTCGCCCG +AAATCATGAAACGTGGCAAATTGAGCACAATTCGATGGAGCCAATAGCAG +GTCGATGAGCTGCAGCGGAAGCTTTCATTGGGATCTGTGCAGTACGTTGG +AACCGATAAATGTTCCTGCATTGATCGGATACAGTAGACGAGCAGGCAAA +TGTATTTTACAAGTGAGATATTCTGAAAATTTTTGAATTTTTTTTCCGAA +TTTAAAATTTTAGTTTCTCGATTGTTTTGAAGTAAAAAAATTGATTTTTT +AGAAAATTATATGTTTTGTTTAATTTATTTAAAAATCTTTAAAGGTGGAG +TAGCGCTAGTGGGGAAATTGCTTTAAAACATGCCTATGATACCACAATGA +CCGAATATCATGATAAAAAAATTCAAAAAAATTTTCTAAATTTTATAGGT +TTTTTTTTGAAAATTGAAAAATCTCAGTTTTTGCCTAATTCCAATTTGAA +TTACCGCTAATTGGATTTGTTCGGTGGAGCGCGCTTGCACGTTTTTAAAT +TTTTTTATTTTATTTTATGTTATTTTCCACCGATTTTTAATGTTTTCGGT +GTATTTTTGCTCGAATTTTAGAGAAAAAGTCAAGATAAATGCAAATTTTC +AATTAAAAAGCACGCTTACAGGCGTAAAAATGACAAAGTACCGATTTTAA +ACGATTTCCAACCTGAATTAATTAATTTCACTGATTTACGCCTGTAATCG +TCTTTTTTAATTGAAAATTTGCATTTATCTTGGCTTTTTCTCTAAAATTC +GAGCAAAAATACACCGAAAACATTAAAAATCGGTGGAAAATAACAAAAAA +TAAAATAAATAAATTTAAAAACGTGCAAGCGCGCTCCATCGAACAAATCC +AATTGGCGGTAATTCAAATAGTAATTAACAAAAACTGAGATTTTTTTCAA +TTTTCAAAAAAATCGTATAAAATTTAGAAAATTTTTAAAAAATTTTTTTA +TCATGATATTCGGTCATTGTGGTACCGTGTTTTAAAGCAATTTCCCCACT +AGCGCTACTCCACCTTTAAAGTGCTAATGTAAACTTTTTGTACACGTGGT +GTCAGAAAGTCCCATTTCGGTTTGATCTACAAAAAATGCGGGAGAAGAGA +CGCAGATTTCTCAACTGATTTCGCATGGTTAAGAACGTGCTGACGTCACA +TTTTTTTGGGAGAAAAATTCCCGCATTTTTTGTAGATCAAACCGTAATGG +GACAGCCTGGCACCACGTGTTTGTACAATTACACATTATCCTGGAACTTT +CCAGAAAATTTGAATTTCCCGCCAAAACTTATGGGTCTCATCACGATGAG +TCACTAACCTCAAACCGATATATTTTCTAAAAACAAAAACTCAAATTTTC +TCAAACTACAGTAATCCTACAGTAATCCTACAGTACCCCTACAGTACTAC +TACAGTACCTTGGCATTGTCCCCCACCAATATACAACCCAATATACCTTC +AAAAAACAAACACGTAATTTTTCCCAAACTACAGTAATCCTACAGTACTC +CCACAGTACCCCTGCAGTACTACTACAGTACCTTTTTAGAACATTTTTCT +GTTTTTCGATTTTTTCGCAAAAAAAATTCAGTTTTTTCAGCAAAAAAATT +GATTTAAAAATATTTCAAGTTACTTTTTAAAAGCTTTTCAAAAGTTTTTC +AATCCGTAAAAATAAAATTTTACGAATTCTTGTATTTTTTAAATTATCTG +AAATTTTTTTTTCTCAAAAAAAAAACTTTTTTTTTCAAGTTTTCAATTAA +TTTCGGCAAATTTCAAAAATTTTAGGTTTAAAAAAATTCAATTTTTATGC +TTAACATTTTATCGACATAAAAATCATTAACAACTACGAACAATTTGTGG +AAAACGTTTTTGGCAGTGGAGCGCACTTGCGCCTCGTATTCAAAAAGCCA +CACAAAATGGTGAAATATTCCCAAAAATCAAATAATTGTTTCGCTACGAG +ACCCAAAATACCGCAAAATAGTAATTTTTACCATAGTAATTTTCAAAAGT +GGCACGTAGACCTGATGAAACGTGTCGTTCACCTCCTCCGAGCTTCTGCC +ACGTGAGCTGGTGCTCCGGCATGGCTGATACATTTGTGAAGTTCGCTAAA +ACAGAAAAATATTATAAATAAGCGGAAAATTTCGTGGTCTCGACACGACA +AAAAATAATAAAAATTATTCGTGGTGAGACCCGAGTTGTTTTGGAGCAAA +ATTCTCAAAATTGGGGTATCACGTGGTGTCAGAGAGTCCCATTTCGGTTT +GATCTACAAAAAATGCGGGAGAAGAGATGCAGAGTTTGCTGACGTCACAT +TAAAAAAAAATTCCCGCATTTTTTGTAGATCAAACCATAATAGGACAGCC +TGGCACCACGTGCGGGGATTAAAACCCGCGCCGCACAGAAAAAAGGCGGA +GTGTTATTTCGCAACACCGCGGCACGGTTTTTTGTTGATCTTTTTCAATA +GTCTTGATATTACTTGCGATTTTTGCAAATTCAAAAAATCAACAATAAAC +CGACCGTGCCGCAGGGTTGCAAACTCCGCCTCTTTTTCTGTGCGATGCTG +ATTTTTTGCGAAATTCACGAATCAAAAAGCACACGTGGTGTCAGTGTCTC +TCATTTCGGCTTGATCTACGTAGATCTACAAAAAATGCGGGAGAAGAGAC +GCAGAGGTCTCAACTGATTTCGCATGGCGCCACACATTTTTGGACAAAAA +ATTCCCGCATTTTTTGTAGATCAAACCATAATGGGACAGCCTGGCGGGGA +TTAGAAACCGCGCCGCACAGAAAAAAGGCGGACCGTAGTTTCGCAACACC +GCGGAACGGTTTTTGATATTACTTGCGATTTTTGCAAATTCAAAAAATCA +ACAAAAAACCGTGCCGCAGGGTTGCGAATTTACGCTCCGCCTCTTTTTCT +GTGCGATGCTGCTTTTTTTGCGAAATTCACGAAAAAAAAAAAGAAAATAA +AAGTACATTTACCGATAAAAGTGACGATAGACCGCCGATATACATGGAGA +GAATAGAGAGAGAAATGTGAAGTTTATTAGAAAACAATTTTGTAAAATTA +TGATGATGATGAAGATTTGCGGAATCTGGTAATCGGTTTTAATTGCCTTT +TCTATTATATTATATTAATCACTTGATGATGTACGGCTTTGCGCTTCCTC +GTCCACGGTCTCCAGATGACGGAATCCACGTGGCGATACTGATCGATTGT +GTTTTGGAGTGGTGGTGCTGCTGGTGCTGGTGGAGGGAATTGAGGTGGTT +GCAGTGGATATTACGCTGAAAAATTGAAAGGATTGGTGGAGGAAATGAGA +GAAATTTGAGAGCATAAATTTTTAAAAATCGAAAAAAAATTTTTTTTTGC +TATTTTTGGGCAGAAAATGGCGAAAACGGTGTTTTTTTGGGTAAAAAATA +ATAAAAATTTACAATTTTTTTTGACAGAAAAATGCGGAAAAGCTGTTTTT +AGGGTTGAAAAATCAAAAAAAAAATTTTTTTTTGCTATTTTTGGGCAGAA +AATGGCGAAAAACGGTTTTTTCAAGTTTAAAACATCAAAACAATTTTTTT +GCAATTTTTTTACAGAAAAATGAGGATAAGCGGTTTTAAAGGTTTAAAAA +ATTTTTTAAAATTTTTTTTGCGAATGGAAATTTTCTGAAAAATCGTGCAA +ATGCCTAATTTGTGCAAAAATCTTATCTGGTCAATGATTTTTAAGAGAAA +ACACCGGTTTTAGAAGGGAAAAAGGCAAAAAACTGGATTTCCAGTGAATT +TTATACTAAAAATGGAAAAAATTCAGAAATTTTTTAAGGAAAAATCAGAA +TTTTCGCAATTTCTACACGAAATATATAGAAATTGAGGAGAACCTCGGAT +TTTTTGCGGAGTTTAAACAATAATTTTTCGGCTAAAATTAACGATTTTCA +GAGAAAAAACTTAAAAAAAACAGAATTTCAGTGAATTTTACACGAAAAAC +GTAGCAAAAAGAGGTTTTTAGGGAATTTCCAAGTCAAATTTCCGAAATTC +TTGCGATTTCAACCCTGAAAAATAGCGAAATTGAGGAAAATCTCGGATTT +TTGCAGATAAATAATATTTTTTCCAATGATTTCCGTCTCCAAAACACAGA +ATAATTTACCAATTCGACGATGGTGAGGAGGGAGAGCCCAGCTCGTTGGT +GACAGCCGTGAGATCCGAGAACAAATTGACGCTGGCTGAAAAAATGGAAT +AAACGCTAAATTGATGATTTCCGCTATTAAAGTGCATATAGAAATACGAA +AAAGCAAAAAAAAAAATTTTTTTTAACCTTTTCCCTGGAATCGAAGAGCA +GTTTGCTTGCGGATTGGACGTCGAAAAGGGCCTAAAATTCTCATTTTTCG +GCCTGAAATTCCTCGAAAAACCCACTATTATTGGTAGTCGGAGATGGCTG +ATCGCCTCGTCGCTGGTAATATAGCACGCCTAGCCAGAATCCGTAGAGAA +AATAAATATAGACTGCCCACACTAGGATGATGGGAAGAAACGACAATCGG +CAGGCGTCTGGAGTGAAGAAATCAAGATTTTTCAGATTAAAAATTAAAAA +TCTTTAAAGGTGGACTACACCCTTGTTGGGAAATGGCTTTCAAACATGCC +TATGGTACCACAATGACCAAATATCATGATTAAAAAATTCAAAAAATTTT +TCTAGATTTTATATGATTTTTTGAAAATCGAAAAAATCTCAGTTTTTGCC +TAATTCCTATTTGAATTACCGCCAATTGGATTTGTTCGATGGAGCGCGCT +TGCACGTTTTTAAATTTATTTATTTTATTTATTGTTATTTTCCACCGATT +TTCAATGTTTTCGGTGTATTTTTGCTTGAATTTTAGAGAAAAAGTTAAAA +TAAATGCAAATTTCCGATTAAAAAATCACTGAAAATGCGTAAAACTGAAA +AATATGCTAGTTTCAGGTTTGTTGTCGTCGGAACTCATTATTTTACAGTT +TTACGTATTTTTCACATTTTTAAACACTTTTTAGCAAACATTCTGCATTA +ATCTTGCTTTTTTACTTCTCTTTCCGATAAAAATACACAACTAATGAAGA +AAATCAGTGACATAATAATAATAATAATAATAATAATAATAATAATAATT +TATTACGCTCGCTGGGAGACGTGAAGGAATACAGAATACAAAAGTTATCA +TTGTTCGCTTGAACTAGAATTGGTGCAGTCGGGCAATCGTTTCCATTCCA +TTAAAATGTTGTCCTTGTCCTTGCGTTGTCCTTGCGTAGACTCCCCCATA +GTGGGCGAGCGATTCCCGAGTGAAAATAATCACGGAATGAAAAAATAGAA +GAAAAATAGAATAAATTAATAAAAAAAATAATGCAAGCGCGCTCCAACGA +ACGAGTTCAATTGGCGGTAATTCAAATAGGAATTAGGCAAAAACTTTTTC +AGATTTTTTCAATTTTCAAAAAATCATATAAAATTTATAAATTTTTTTTG +AAGTTTTTTAACGTGATATTTGGTCATTGTGGTACCATAGGCGTGTTTTA +AAGCAATTTCCCCACAGGGTGTAGTCCACATTTAAAAATTAAAAATTAAA +AATTCTACCTAACAAAATCGAAAATTTCAGATTCTCCTTGATTAAAAGCT +TTATTATTGAGTAAAGAGTCCGCAGCGTCCACACGGAGAGCGGGTACAAG +ATGGAAATCTGAAAATATTTAGGATTTTCAAGGGAAAATATCGATTTTTT +TTAGCAAAATACCACAGAAATTGCGGATGGAATGAGTAGAAGAGCCGGGT +TGACTTTCCGGGGAAAGTTTCGACGTGTGATGCTCGTCTCGGAGAGCCTC +ATTCCCAAGAATCCGGTTGCGATGCTGAAGAAAATCGATGGAAAAAGTCT +AAAATATCCCCTGAAACCCTACCTAAAAATCAGAAAATACGAGAAAATAT +TGATTAAATTCCGAGCCGGCACATAATTCGGGCGGATCAGCACTCCATTG +AAGTTTCGAAACGTTTCGCCGTTCCACTGAAGTCCATCGAAGCCGGGAAC +GGATGGCGGCTCGAAATGCTCGTCGACACTCATTTGACTGGCCCTGTAGA +GCCCGATGATGGCAATGGCGAGCATTCCCACTTCCACATGGAATATCAGG +CTCTGAAAATTAAAATTTAGCTTTTAGACGGAAAAAATCGATTACTTTGA +CATGAACTTGATCGAAAAGCCAGCGATACGGGTATTTTCGGTGCAGGCGG +CCTGATTCCGGACGTGCTCCTCGAGATATATTGGAATTTGTCGAGCGGAT +ACTAATATCTGCCATTTTTTCGCTGAAAAATCAGAAAAAATAAGTTTTAA +AACAGAATTTTAATGGAAAAATAAACGGAAAAATTCGAAACTTTTTTTTC +CGCCATTGAACACCAATGTGCCTTTAAGGTACGGTAGCTCTTCGTGGTGA +GACCACTGCGCCGCGCATCTGATTTCTCGTGGGAAATTTGTTTCGAATCC +TACGTTTTTTACAGATTTTTCTTTTTTTTCGTTTCGCTCATCATTTTTTT +GTTGCAAAAAATCCAATTTTCAGACAAAAATGTCAGAACGCCAATCCAAA +TATTTTGACTATCAAGGTATCGTCATTTCCTCCACTGGACAAGATAACCA +AGATTCGGAGACGGACCTCGTTTATCTCATTCAAGCTCATGTACGTGAAT +TCCCTCCGTTTTCATATTTAAAATAATAAGCTCGTTTTCAGGGAAAAGCG +GCCCCGAAGAACATCATGTACGGTGTCTCCAAGTGCGCATTTGTTCCAAC +AAACTTGGAGAGGAATTTCGATAATATCGAAGAGGCAAAAAATCTTGAGT +CAGTATTTATTTGATTTGAGCCCATTTTTAATCTGTTAACACTTGAATTT +TTAGACGTCGATCCAAAATCCCGCTAAAGTTCGGTGAAGTCATCCTATGG +AACGAATCGGACTGTGATCACGATAAGAGGATAATCCTTCATATCAAACG +AGAAAAACCAATTTATGAAGCGTCTTCCAGCAGAAATGGACTTATTTTGA +AAGTCGGTGGCGTCATCCAGCCCACCTCAACGACCTCGTTCTGGACGCCA +TTATGCACCGTCACCATGCGTATGTTTCTTCTTGATTTTCGTCTCTCTAA +CCATATATTTATTTCAGCAGAGACAGAGGCGACCCGTGCGGAGCCAGACG +TTTGGCTATACGCCTGGATTCGATTCGAAACTACCATGAAGAGTGGTCTA +GATCCTTTCAATATGACTGCAACATTCGAATCGTTTGACAGTTGCGATCC +ATCCGACCAAGCACGCGTCTGTGAAGCGGTATTTGCTTTTTAAAAATTTT +TTACGGGATTTTGAACAAATAACTTTCAGCCATGGAACGCAGGCTCTCCT +GACTCTAAATTCGGTGTTTGGCGCCCGGATCCAAAGCCTGCTGATAGCGA +CGACGAAATTGATATCGAGCCGAGAGAAGGCTGGCACTTGCCAGAAGACA +AATGGGCCGAGGTTAAGGTTGCTTTGTGGATTCTCGTTGACAATTTGATT +TTGCAGGTCATCAAGATGCAGCTTGGCCTGTATGTCGGCGAACGCCTACT +GATTTGCAAAGAACTCTCGCAGTTCGACTTTATTATCCCACTGCAGAAGC +CATTTTCCCGAGGAACGGACAAGACTTTGATCTACCCAGCCGTCGGAGAA +TACTTTCATTTCAGTGCTATTTGGTCGATGCAGCACAACGGTTTTCTGAT +CTATGAGCTTCAGCCAGTTCCACTTCTCAGACAGCATGTAACCTCTGTCA +ACGGAAATGTAAGTTATAATATTGATTTTTTTGTCCAGAACATAATTTTT +ATTTCAGCTCCTTACCCGCGTCGTTCCTGCCAGTATCAGAGGTCTCTTCG +TTGACAAGGAGGGCACTCTTGGATTGATTGATGACCCACACCATCTTCTT +TCATTCTTCGAGTTTCATCCAGCTGGTTATGAATTCTTGAAGGCTATGGT +AATCATGAGTGGGTCTTATTTTGAAACAAACGCTTTCAATTTTCAGGCCG +AAGTTCGTGCTGTTCGAACTTCAGAAAACAAATCTGTCCGTTACCGCATT +GTTCGTACATCGGGAATGTCCATTTTTGAAAACTGGCTTCGTGATACTCA +GGTCTCTAAAGTTAAATTAAACTCGTCCTTTTCACCCCTGAATTTTTCAG +TTCGTTGTTGGTCCAGTCAAAGGAATTCGAATCAATGAAGACACTGTCAT +TTGTGCCAAACATCCGAATGTCTACTTCAAAATCCCCAATAACTTGAAGG +AAGGAATCCCCATTGGCGGAGGAGTTCAATTCGTTGGAAAGCGACAAGCT +GGAGTCGACAGTGAAATTATGATCACCGAATGTTCTCCATGTCCAGCGTT +CACTTGTAAAAATTACTCGGTCTCTGGTGATACGGTTAGTCTTCAATTAT +TTAATAGTTTTTATTCTATGAGGAAAATATTCAGCGCTTGTTCCAAGTGT +ACTTGAAGCCAAATTGCGATCATGAGCAGTTGGCGGAGAGTGATTCGATG +GGATTTGTGGATTTCAGAGAGTTGGAGACTCCATGTAGAGGAAAGTGAGT +GTGTCAGGATTTGTAAAAATAATTGTAACTGAATTTTAAGGTTCCTGGCA +TGGGTCCGTGAATCCATTACTGTCAATGATTGTCGCCGTGCTGCTACCAT +CATGGAAGTATGCTCGACAGCCATCTGTCCTCCGTTGATTGCAATGAGCG +CGAATTCGAGCAGAGCAACATCGGCCAGAACTACGCCAGCTGGAAGTTCC +ATTGGATCCAGATCATCAATTCAATCAAGAGCATCTGCAGCTACTTCAGT +GAGCTCAAACGTAAGTTTATTTTTAAGGTTGGAAGATGATAAAAACAAGT +TTTTCAGCGATTCGTTGGCCCTTCAAGCCGCAGAACTCCATCTGGTACTC +CACAAAGCTCAACATCTTCCAGGGTCTAATTAAATATATACGCATCCCGT +TTTCCCCCGTATTTGTGTTTCAAATGTTCTGCTCATTTTTAATCTACCCG +TTATCCAACCAAACATTTATTTATTTAAACTTCAAGTTCCACCACCATCC +CATTCCGCACAACTTGTCTCTCGTAATTTTCTCGTGCTCTAATGAAGTTG +TGGTAGGTTATTCTAGTGAATACACCCATGTTAAGCAGCGAATACATCCA +GAAAAGTCCCAACAAGCCGGCAGCGAGATACTCCCCCCAAAATGATGGTT +GATCGGTACATCCAAGATAGGGTAGCATCGCGATAGACGTGAGCAAGTTC +GTTATGCACTTGAAAAACTGAAATTTCAGAAAAGATTAGGTGTATCAGAA +GGTTAAAAACAAACAAATGACATATAGATGAACGAAGCCAGTGATGGAAT +CGGATTCCGAATACGAGAAGCCATTCCCGGAGATACTGTGATAAGAATCT +GTGTGATCGAGAACACAATGAGCACACCCACCGGGAACATGAATTCCATG +GAAACACGGAGGCAAAGGTCACAGTACTGCAAAAAATGCGAAATTTTGGC +GATTTTTGCTCTAAAAAATGCACTGGCCGGGTCTCACCACGACAAATTTT +TGTTGTCAGTTGAATGCCAATAGAGTGTGCGCCTTTAAGGAGTACTGTAG +TTTCAAACTTTTGTTGCAATCGATTTTACAGTTTTCCCGAGAAACAAAAG +TTTGAAACTACAGTACTCCTTAAAGGCGCACACACTCTTTCCGCATTCAA +CTTAACAAAAGGTTGTCGTGTCGAGACCCGGCCACTGCATTTTTGTAGCA +AAAAAAATTTGAAATTTTCAAGTCTGGATAATAATATATAATATTTTTAC +CTCAACTATGGGAATTTGCATTTCCAAACTATCCAAACAATCGCTGAACC +CGAAAGCATCACAAATAATCGATCGATATTGTCGCGGAATGTCACGTATC +GATTGGTAGATCATGAATATGTTGCCAAGTAACGCGAAAATCTTGAAAAA +TGGAGGATTTTGCTTTTAAAAAATCCAAAAAAAAAAACTTAAATTCGACA +ATTTCCTGTTTGAATTCCCTCCAAAATGAGAACTGCAGGACCCATCAGCG +ATTTGAGTGGGCGGAGTCCGAGGGCGCTGATTGGTCGTGCAGTTCTAATT +TTGGAGGGAATTCAGCCAAATTTGAAAAATCTCGTTTTTTTTGCAATTCT +TTTGTGGTATTTTCGACATGGGGTTCTTTCTGGCTTTCCTCATCAAGGGT +GTCAATGTCCCGTAAAAATTTCGAAAACGGGACAACGGGACGTCCCGTTT +TTTTGAAAACACTCAAAAAACGGGACAAACTGGGCGGTTAAAAAAAAGAG +TGCATAGTTGGCGTAAATTTTAGTGTATTCGAGGCAAATTATAAAAAAAA +CTGCATGTAAGTCATTAATCTGCATGAATTTAAGTCTTGAAACAAAACTC +AAAAACAGAACTTTAAAATGTGCAACAAAATCATGAGAGAAATTGTCCCG +TTCCCGTGATAATTTTGAAAACGGGACAGCGGGACGTCCCGTTCCCGTGA +AAACACTCAAAAAACGGGACAACGGGACAAACGGGACACGGGACTTGACA +CCCTTGTTCCTCATTAAAATTTTCGCGCTCCATTGATAATCGCCCTGGGA +AAGTCGTGTACTCCACACGGACAAATCACATTTAGTTTTACAACTAAAAT +CGAGAAAATTGGGAGAGTTTTTGCCGCGAACCTGGCCTAGTTCGCGGCAA +AAACTCTTCCATTTCAAAATATGGGCGAAGCCAGAAATCCGTGATATTTT +CAGCATATTTTTTTGATTCGAAGCAAATCTCAGTTTCTCACCACAACGAA +CAACTTCACATTCGGATGCCGCCCGTCTTCGAAACGTGGAATTCCAACTG +AATTCACCGATTCGACACTTGAACCGGGTGACATCATCATATTTTCAACC +AGCTCATACTCGAACTCCGGAATATCCGGCACCACATCAATCGGTGCTGG +TTCTGGCGGTGGCGGCTCAACTGACACTTTTCCTTGATCTAAAATTTGTT +TTTTTCTGAAAATTTGTCACTGTACCAAATCAAAAAAAAAACCTTACCAG +AACTCATAATTTTTGGATTTTAATTTGTAAATTGCAAAACAGAAAATGAA +TTGGAATTTTTTCACTTTTTATTTATGGGAGGGGGAAATTCTTTGTTGTT +GCAATAAAGTAAAACAATCACAGTAAATGCCAGTACAATAGTTTTTCACG +TGTAATATATTAACCAATTACTATATTCAATAACTCTGTCGTCTAAATAC +ATAGGGTAGGGGGGAAGGTGAGGGAAAATGGAAATAATAAAGTGAAATGT +TTTGTGTACTTGCGATAAAACAATCAATAAATGGGAACAAGCCGATGATA +AACTGATAAACCGAACGTGAATATCGAGAGAGGGAGGAAGAAAGCGTATA +CCCGTTAATGAAATCAAGTTAATGGAATTATTTGGATTGAAACAAAACAA +CGAAAATATCAATGTTTGAGCATAAGGAATGAGGGAATGGCACTGGTGGT +GGTGGATAAATGAATCGGGGGGAACGGAATCTATGGAAGTTTCGAATACA +TCGCATCGAGTTGCTTCGAGTAGTGAGCCTTCAGCTTCGGACGCTTGCTC +TTCAACGTTGGCGTGAGAAGATCATTCTCGACGCTGAATTGCTCGGCGGA +GAGACTGATATCGCGCACTTGCTCGAACGAGAAGAGCCCGGCTTTCTTGC +CAACAGCGACCATGTCATCGAGGATCGCCTTTTTGACGGCGTCGTTGTTG +CACAGCTCTTCGAATGTTCCCTTGATTCCTTGGTCGGCCATCGCTGGGAC +GAGAACCTAGAAAAATTGAAAATTACATATATATATATATATATACACGC +TCTCCTCAAAGCCGAATAATTATTAGAGCGCGCTTACTGCGCTTCGCGTT +TCTGCATCCGCGGCATTTTGACTTTACACTGAAAAAAGCAGATATTTCAG +ATTTATCGAATTTTTAGCTTTTAAAATTTTTTTCTGCATTTTTCGAACAA +ACCTTTTGTTAAACAGTGAAAATTGAATTTAAAATGACTAAAATGAACTT +TTTTCGTTCACTGGTTGTGAAATGGTTTGAATTTGAAGAAATCAAAGGGA +TTTTTCTGAATTTTTTAATAATTTTCTATTAAAAATCGGTTTTAAACCAT +TTTTTGACCCTAATGTTAAGTCACAAATGTATTGAAACCGGTTTTTAATA +GAAAATATTTAGAAAATAAGAAAAATCCCGTTGATTTCTTCAAATTCAAA +CCATTTCACAACCAGTGGACGAAAAAAGTTCATTTTAGTCATTTTAAATT +CGATTTTCACAGTTTAACAAAACGTTTGTTCGAAAAATGCAGAAAAAAAA +TTTTAAAAGCTAAAAAATCGATAAATCTGAAATATCTGCTTTTTTCAGTG +GAAAGTCAAAATACCGAGGATGCAGAAATGCGAAGCGCAGCAAGCGCGCT +CTAATAATTATTCGGCTTTGAGGAGAGCGTGATATATATATATTTTTTTT +AATTTTGAAAATATTTAAAACCAAAAAACCAACCTCAGCATCAGGTACAA +CAATAGCAATGAGACACGTCTTCAGTGATTCTCCATGAACAAATGATTGA +GCGACATATTTCGAGCGGACATAGATGTTCTCAATCTTCTCCGGTGCCAC +GTATTCTCCCTGCGAGAGCTTGAAAATGTGCTTCTTGCGATCCACAATTT +TCAGCGTTCCCTCAGGAGTCCATCGTCCAATGTCTCCAGTGTGCAACCAT +CCATCCTCATCGATCGTCTCCTTCGTTTGTTGCTCATTCTTATAGTATCC +CTTGAAGATGATGTGTCCCTTGACACACACCTCGCCGGCTTGATCCTTCG +CGTAATAGTTCAACTCGGGCACGTCGACCAACTTGATCTGACACGATGGG +ATCACCATTCCGACGTGTCCGGCTAGCGAATCTCCTTCCATCGAGACAGT +GCAAGCGGCGACACATTCCGTTTGACCGTAACCCTCGACGACGACACATC +CCATAGCGGCACGAACGAAGGTGAGCACATTCGTCGAAAGTGGAGCCGAT +CCGGTGATCATCAGACGCACACGCCCTCCGAATCCTTCGCGAATCTTTTT +GAATACCAAATTGTCGAAGAATCCGTCATTTCTGATATTGAAGCTGGAAA +AAAAAAGAAGATATTAAATACTATCAAATCATTCAGACCACTCACTTTGC +CATATCTCTGGCCTTGTATGAGATAGCGAAATCAAACAACATCTTCTTCA +AAGTCGACTTGTTCACTTCAGACATCACTTTATCGTAAAGCCGATTCAAG +ACACGTGGCACCACTGGCACCACAGTCGGCTTCAACTCTTTGATATCCTC +GGCCAACACACGTATGTCACCACGATAGAATCCGACTTTCGCGCCGACAC +AGAAGCACACACTCTCGATGACTCTCTCGAGCATGTGAGCCAACGGAAGG +AAGCTGATCATCGAATCGGTCGCCGCGATGCCACTGTGCTTGAAGAAGTC +CATACAGACACCGTCGGCGATCACGTTCGCGTGAGTGAGCATCACACCTT +TCGGTGTTCCAGTCGTTCCTGACGTGTAGCATATGGTCGCAAGATCCTCT +GGTGTTGGTGGAATGTGTGCTGGACGAGTCTTGGCGTTCTTTCCAATCTT +CTCGAGATCCTCGAACGTGAGCACCTCGACTCCGAGCGATGACGCAGTCG +TTTTGAGCTCATCGGTGACTGGTTCCATCACAACAAGTGTGCTCAAACTT +GGGCATTGCTCCTTGAACTTTAAGAGACCTGAAATCAAATTTCCTTTTGT +TTTTAATAATATTCCTTATCAAACTCACCAGTGGCCTTTGAAATATCATC +ACAGACAACAATCTTGATCTCTGCCTGATTCAAAATGAATATCGACGCTT +CTGATCCAAGGGTCTCGTAGATCGGCACAATCACATTCGAATAGTTGTAG +GTGGCGAATTCGGTGATGATCCATTCGGCGCGATTCTTCGAGTAGATCCC +AATGTTCTCCGCGTTGCCAGTCGGAACGCCGAGCTCACGGAACGCGACGG +ACACGTTGTCGGCTCGCTCGAGAATCGTATTGTACGACTCCCACACGTAC +GGGATTGAACCATCCGACTGTTTGACTCGACGTCCGAGCATCGGCCCGTT +GTTCGAGAGACGGGCTCCACGGCGAACACCCTGGTAGAGGGTGCGCGCGT +CTTCGAACAGGAAAGCCTGGAGTTCGTCGTCCTTCAGGTAGGCGCTGATG +CGGGAACCATCCTGGAAATTAACATTTTAGTCGGGGGGTTTTTTTGGAAT +TTTTTTTTCGCTCGTTTTCTATTGTAAACCGAGCCACGACGCGACACGCC +GTAAATCGACAAGCCCAAATGGCCTAATTCGGCAAAATCTTACATTTAAA +AATATGAGGGAAGACAGAACTCCGTGATTGGAGAAAATTAAAGGAGGACT +AACGGTTCGGACGATTTTGAACGTATAGACCCAAAATGAGCTCAAATGAA +TGAATTTCGTAATGAAACTGCTCAAAAATTTTTATGGCGGTTCAAAATGT +TGAAAAAATTACACTGATTTTGGCTAAAATCACGAATTTTCCCATTTTTC +CGTGTCACATCTGTTCGAAGTTGGATTTTTTGGAATTATCGTTTTTTATT +ACATATATTGGTAGTTTATCTCATTTAATTTCGTCGATTAAAGTACATTT +AAAGCCGATAGGTAACCAATTTCGATAATTTTTGGTCACCTATCGGCTTT +AAATGTACTTTAATCGACGAAATTAAATGAGATTAATTACCAATATATGT +AATAAAGGACGATAATTTCAAAAAATCCAATTTCGAACAGATGTGACACG +GAAAAATGAGAAAAATTCGTGATTTTCGCCAAAAACAGTGTAATTTTTTC +AAAATTTTGAACCGCCATAAAAAATTTTTGAAAATTTTTTGAGCAGCTTC +ATTACGAAATTCGTTCATTTGAGCTCATTTTTGGTCTATACGTTCAAAAT +CGTCCGAACCGTTAGTCCTCCTTTAAGTTTAAAAAAAAAACGGCATATTT +TGCCCAGTTTCTCTCCAAAACTCACCGGCAAAATGCGACTCTGATTCATC +GGATCCACCAGTGGCTTGACATTTCCCGAATAGGTGACCCCACTGAACGA +GTAGGATCCCGACGTCGATGACGAGCTCTTCGACAAGTAGTATCCGAGGC +CCATGGTGACTGCGGCGGCGGCTCCGATTTGAACGTACGGTGGAAGGGAA +GAGTTCGAGTTTGGTGCCGAAATGAAATCGACAATACTTCTGTAACAATT +GAAATTATATATAGAGAGGACGGGTGATGATGATGAGTCATCCAGGTTGT +TGTTGTCGCGCGCGCGCGCCCGCACTGTTCCCCACAAAACAAACAACTTA +TTTGAAATTATGAAATCGAAGTTTCTTTGTTATTTTATTTTATTTCACAA +GATGGTTTTCATGTTTTATATACCATTCGCAAAAACAATACCTAGTTTTT +GCTCGTTTGGACTCAGAAATTTTGAGACTTTTCTGAAAAGTTTAATGGCA +GATCAAAATTTCGGAAAAAGGTGAATTTTAGCGAAAATTCGCCGTGGTTT +TTCGAAATTTTGATCTGCCATTAAAGGTGGTGTAGTCGAATTTTTTTATT +GCTTTATTAGACTCAAAATTGTCTGAAAACACCGAATTTCATAATAAAAC +TTAAATGGCCTAAAATTAGCTAAAATTTGAAATTTGACCGACTTGTCAAG +CGGCTGGAAACGTTTTTTTTTTGAAATAACCGTCAAATTTTGAATATACA +GTGCAATTATCTTGCGTTTTCAACTTTATTTAGGTACTTTAAAGTCGATG +AACGGCGAGATTTGTTTTTAATTTTTCACGAAATCTCGCCGTCCATCGAC +TGTAAAATACCTAAATGAAGTTGAAAACGCAAGATAATTGCACAGTATAC +TCAAAATTCGACGGTGTTTTCAAAAAAAAAAAAACTGTTTCCAGCTGCGA +CGTCGGTCAAATTTCAAATTTTAACTAATTTTAGGCCATTTTTTGAGCCG +TCATAACTTTTTTTGAGGAGTTTTCAAGAAGTTTTATTATGAAATTCGGT +GTTTTCAGACAATTTTGAGTCTAATAAAGCAATAAAAAAATTCGACTACA +CCACCTGTAATGGCAGATCAAAATTTCGAAAAACCACGGCGAATTTTCGC +TAAAATTCACTTTTTTTCCGAAATTTTGATCTGCCATTAAACTTTTCGGA +AAAGTCTCAAACATTTTGAGTATAAACGAGCAAAAACTAGTCATTGTTTT +TGCCAATGGTATATAAAACATGAAAACCATCCTGTGAAAAAAAAACAACA +AAAACACTTGAAATTCGTAATTTCAAAGTTCTCCAAAAAAAACATACACA +CACCTCGATTGAGACTGTACCCACGCAGCCGTGTCTGTGATAACCATTCT +GTGTGTTTCTGTGTTTAAGTGGCCTATTTATAGTCTTCTGCCAAAAGACG +AAACCGCTTCTAAAATGAGATTAAATTGAGGTGGAAACGACGACGACGAA +GAGGTGGAAGAAGTGAGGGTGAAAATCGAAAAAACAAAGAAGAGATCAAA +GTTATTCCATCTTTAGAACTTTCTCCACTGCCAGCAATTGATAATAATAA +TAAGATTTTTATGTTGATAACTCTTTCGGTATCAATACAAAAAGGGGTGA +AAACCCGCCTCGACAAGCCTTTCGATCAGGCCATATATTTCTTTATCACA +CTCTCCGCACATTTCGGAACAACTTTGACCTCCCCGGCAAGGGGGCAAAA +GTTTCGAGAAGTTGTGTTGCGCGCGAAGGAGATGGAGAAGATGGAGAAGA +TAGGCAAACACGTACACCTCCTCAAACAGTAGTAGTAGTGATAATTGATT +TGATTAGTGATTCGGGTGGGCAAAACGAGAGAGATAGAAAGAGAAAAAGC +GAAGAGGACAACGAACACGTGTAATCAACCGTGTGCCAAAGTTCTCGCCC +TTTGGACTAATTGCAGTTTTTTTGGAGGAAATTCAATTAACACTGAAAAC +TAGTTCGTTTAAGTGTTTACGCTGAATGGGCCAGGTTTTGAGGGAAAACG +ATTTTCGAAGAACTTTAAATGTGGGGTACCGAAATCTGAAAAATATTTTA +AATTGACTCCAAATTTTCCCCTGACTCCGAATATCGATGCGAAAAAATTC +AAAAAAAATTTTCCTGATTTTATATTTAAGCTTGAAATCGCCGAATTTCA +TTTAGAAATTCGCATTGGAGCGCGCTTGCATCGTTCGATTTTTTTTTCGT +TTATTTTATTTATTTTCGCCGAATTCAATGTTTTTAAAGCCAGTTTCATT +CATTTTTGTCGAGTTCTCATCGAAAATTTTTTTGACAAAAATTAATGAAA +CTGATTAAAAAATTAAATTCGGCGAAAATAAGTAAAATAAACGAAGAAAA +TCAAACGATGCAAGCGCGCTCCAATGCGAATTTCTTTGGGCGCGAAGTTG +AAAAAATGGCCCGGGGCACAAATGAAATTCGGCGATTTCAAGCTTATATA +TAAAATCAGGGAAATTTTTTTGAATTCTTTCGCATCGATATTCGGAACCA +GGGAAAAATTTGGAGTCAATTAAAAATATTTTTCAGGTTTCGGTACCCCG +CCTTTAACGGATTTTTTGGCTTAAAATTGGAAACTCTTGGTATAAAACTT +GTAGAAACACCGAGTAAACTGTACACGTTTTAGACGATAATTCAAAAGTA +TCGAGGGAAGTATCCAGAAGTTGAAAAATTGCGAAAAACAGGTAAAATAA +GGAATTCAACGCGTGAATTTTGCATTTTTAGACTGAAAATAGTGTGGTAT +TTCTTCAAATATAGACGAAAATATCGACTCGCACTGGTTTTCGATCGATA +TTTATAGGTCGAGTTCATTGCTATGCACAACATTCCGGGAAAACACGAGA +TTTGAGGAATTTCTGAGCAACTTCTGAGTAAAGCCAACAAAACATTTTGT +ACAATTTTCTTGTTGGTCTTGCTCAGAAAATTTTCAATCAAAAACCAATT +GGAAATCGATATTTTCTGCTAGTTTTGAAAAAACACATGATTTTTAATCA +AAAATTGTTAAATTCATGCAATTTTCCAAAGTTTTACACGATTTTTTCTC +TGGAATTCACATGCTTTTTAAAGCAAACGGCCGTTTCTCGTTGTTGGCTT +CCACGCGATTCCATAGAAACACTGGGGCACCAGAGAAACCGGGGTCGAAG +CAAATGACCAACAAACAACAAACGGATGTGTGCTTTTTCTTCGTTTTCGT +CTTCACGAGGAACCACCACGCAAAATGGAACTACAACTACGATTGATAAC +GAAAAAAAAAAAGAAGAGATGATGATAGTTTTTGCAGCAATAAAAAGAGT +GATAACAAGATACACTCTATCTCACCCACACCTTTCCGTTCAAAGATAAG +GAAATAAGATTCGGGGGGTTCAAAGTGTTGGAGCCAAAAACGGAAAACGG +AGGGAGCAATTGTTCGTTGAACGAACAATAAAAAACCATCATCTGCGTCT +CAAAAATACACGTGTAAGTGAGCGAGTGAGTGAGTGAGTGCCGGGGAATA +AAACGAGTTATATGACCAACACAACGAGCGACGTTGCTGCTGCGTTTCCT +CACTCTCTCCTAGTGAGCGTGTGTGCGCACCACACTCACATGAGCGCATG +CAAGGGTGTATGCGCAAGTGGTACATCGACTCGGTATGAGAAGGACAGAG +CAGTAGTAAGGAGCACACGTTATGTTGCTCCACTACTCACTGTTGCGTAC +CGTGTAGCCTCTGCGGGCCACCGCGGTGCAAAGTACAGTGGAAGGAGGAG +AGTTGAAAAATTGGTGTTTATTTTACTTTTAAACTCGTTTTCCTCCGGAT +TTTGAAGAGAATTGGTTGACTTTTTGAATTTTAGGCGAAAAGCGCGGGAA +AAATCGAAAAAAGATGTGAAAACGAGTGAATTTTAGGGCAAAAGTGAACC +GACAATTGTTATGAGCAATCGGGCTTCTCGGTCGGAAAACAGATCACAGA +AAAATCGGAAAATCCAGCAAAATACTCGAAAATTATGCAATTTTCTAGAA +TTCCAAGCGAAATTTTCTAGAATTTGAGGCAAAATGATACGGAAACCAAC +GAGAAATCCAGAAAAAAAAACTATTTTCATCGAATTCTAGGTGAAAAGCT +CTGAATTATTCGATTCTCCGTCGGGGTAGACTCAAAAATTATGCAATTTT +ATAGAATTCTAGGCCAAACATCGCAGGATCGCCTACACAATTTCCGGAGA +ACGATGAAAATCGGCAAATCTGAAGCAAATAGGAGTGAAGGAAGAGGCTT +CGGATCAGTTTTTCTGAAGAAAATACAAAACTTTCGCTTTCGCAAAACTT +TCGGGAAAATTCTCAGAAAAGGCGTCAAAAGCTCAAAAAATCGACGTTGC +ACGATTTTCGACGGAAAAATAGAGTAAAATATCCGAATTTCTGCTTTAAA +ACTCGAAAAATTGCCCAAAAATCCGTTTGTTTTCGCCAAATTTCTCCTAT +TTGGGGGTCACAAGGCGAGCGGGAGCCGCCGACGACGAGATGAAGAGCTC +CACAGAGCCCCTGAGCCAACAACACAACACTCACCCAAAAATATTGGAAT +TCTCCGGAAGGAAATCGTCGTACGACGACGGCGGCGGCGACGGTGCCATT +TTTCATGGGGAAAATTAGAACCTTGTTCGAATTTGTGATTTATTATCGAT +TTTCTATGTGCCACGTGTGCCCTATTGCGTGACCCACCTGATTAGTTGCG +CGAGTATTTTGTCAGTGCGGTCGACGATCACCCGAAGAATGGAGAAATTG +TCTGAAAAATGCGAAAATTGGCTATAAAACGACGGAAAAAGAAATAAAAA +CAAGTGAAATGAGGCCGAGAGGCAGGTGAATTGTTTATGCAATTTTAGAA +ATGTGATATTTTGGCGGTGTAGATCGAAAAAAATGCGAAAAACACGAAAA +CAGGTCGAGAAATTCGCAAATTTTCGACGACTAAAATTCAAATGCACAAC +GTTCGCGCGCGCGCCGAAGTACGGTAGGTCCCGCATTTTTGCGCGCGCGA +AATTCAAATTTTAATTTTAATATTTTTTCTTTCTTCTTTTCTTTGATTTT +TTAAGAATATTGTGCAAAAAATTCGTTCATTTTTCGAATAAAATTGTTAA +AAAAGACGAAAAAAAAAAGAAAAAATAAGACAATTTCTCGGTGGCATACA +AATAAATACAAGTTATTGTTCGGGAAAAAAATCACAATTTTACATTAAAT +CCAGGTTTGTAATAAAATCAATTATTATTTTATTTTCTTCCAAATCCGGC +ACATGGATTTGGGCATCCGCTGGTCATGCAGCAGCCACCTCCACTCCCTC +CGAGACACGCCAACGACTCGCCGGTTGAGATGGCGAGAAGCACGAAGCAA +ACGACCATGACCTGGAAGAAAATGTGTGAATGTTAAGGTCTCTTAATATT +CCAATAAAATTATTTGGTTTTTTTTTACCGGTGTTCTTGCCAGAAAAGTG +CAAAAATTAATTAAAACTCTAATCGTGGCGAGACCCATCTTAGAAACGAG +AGTATGCGCCTTTAAAATTGGGCTACCGTAATAATCGAATTTTTGCAATC +TTGCAATTGTTGATTTCCGAAGAGCGTTAACAAGAAAACATTTGATAGAA +ATGACACATGAATTAGGTAAAATTTGGTTTTTTTTTAGATTCTTATAATT +CAGATTTCTATTTTGGACACGGAGTTCTGGCCTTCCTCATTGAATTTTTC +GCGCTCCATTGACAATCGCCTGCCGGACAACGAGTGGGAAAGTTGTGTAC +TCCACACGGACAAATACATTTAGTTTAACAACAAAAATCGAGACGCGACG +CGACACGCAACGCGCCGTAAATCTACCACAGATATGGCCGAGCCATAATG +GCCTAGTTCGGCAAACTCTTCCATTTCAATTTATCGATGTCAGAGTGTCC +CATTTCAGCTTGATCTACCTAGATCTACAAAAAATGCGGGAATAATACGT +AGAGTTCTCAACTGATTTCGCATGGTTAAGTACGTGCTGACGTCACATTT +TTTGGGCTAAAAATTCCCGATTTTTTTGTAGATCAAAAAACTGTGATGGG +ACAACCTGACACCACGTGATTTATGAGGAAAGCCAGAAATCCGTGATTTG +GAGAGCACAACAAAAAAAGAAATTCGGCCACTGATTCGCGGCCACGAGCC +ACTGTGCCTTCTCAAGATATTAGTTAATAATTGACGCTGTGAGACCCACA +GTTAAAGGCGCATGCTCAGCATGACTGGCCAATCTAATAGCATCTACAAT +GATAATTGAAAAAAAAACTCACAGTTTGGCAAAGTTTAGCGACGAGTGAC +ATAATTCTCCGAAAGCTTCAGCTGAACAATTTCAGGGATTACTTGCTGTT +TCCCATCGCTTCACCGTCTTATATAGTGCCATCGCCGATTGGCAGAATGG +GATACACCTGCCCCCAACTGCGCAGTTGAATACGATCCGTGTCTCTCTGC +GTCTAGCGGTTCTCCACGATGTTTCTTTGGCGGCGGTGAAGCCGTGTGTG +TGTGTGTGGCTCCTCCATTCTGATTGAATGTGTAACACTGCGGGCAACCG +ATTGGTTTTGGCGGCGGCGGGAAAACGAATCCGGATATACTACATACACA +AACACACACTCACACACACCGAAGGAACTTTTCAGAGAAACCTGAACTGG +CTTTTTATGATTTAAGTGCTTCTGCTGCCAGCATGATGTGGTGGTTGTGT +GTTGTCAATAGGATTTATGCTAATTCCTGACACATTCAAGAGATGAAACA +TCAAACCGGGTAGGAACTTAGTCCACCCAACACTGTGAGAGATTAATAGA +ACCTTTAAAAGTGGCACTTCTAGGCAGAATTCAATAGAATGGTGGGCGCC +TTGGAGCCTAGTCGACCTGCGATGTGAGTGGCAAGGTTGGCAGAGCTAGG +ATAAGCTTCTGGAACTGTAGGACTGTAACAAGCAAGGATCCCGCTCTGGT +ACTGTAGTGAACTTTGAGATCAAATTAGGTTTTTCAATATTTAACTAGCA +CTGTTTCCGGCCCTGATCTTAGAAAGAAAAGAAAAAAAGGATGTGAACCA +GGCGTGGGCGGCAAACGATTTTTTTCCGGCAAATCGGCAAATCACTAAGT +TGCCGGAATTTAAAATTTCCGGGAAATCGGCAAACTGACACTTTGCCAAT +TTGCCGAACGGCAATTGCCGCCCACACCTGATGTATACATATATATGCTT +TCACTCATGTGGTGCCAGAATGTCTCACTGCGGTTTGATCTACGAAAAAT +GCGGGAATATTTTTCCAGAAAAATTGCGGCGTCAGCACGCTCCTAACCAT +GCAAAATCAGATGAGATGTATGCGTCTCTTCTCCCGCATTTTTCGAAGAT +CACAGCAAAATAGAACTTTCTAACTCCACGTGTCTACTGAGAAAAGAGCC +GAAAGCTTATTTTCCACGTATCAGGGATCGGAATCCCACCTAGCTAGTTC +ATCCTATTGCATCATTGAAGCATCTTCCGGATTCTCCACTTTGTTTGCTT +TTCGAAATCGTTTCAAACTGAAAGCCGCGCTTTCAAGGCCGTCTTCTTCC +GATTTTCCGATCTACCTTTTGTTGATCATCACGTGCCTGGCGATCACAAC +ACTGTTCAACCGGAATATCTGAAGATGTTCCACCAAATGGATCGTTTTTC +TCAGGACGGAAGAATACTAATTTGCAAAAAGTCTGTTCTGTTCTAAAAGT +TCTGAATCTTCTGAAAAAATTTCAGACTTAGATCCTGTCATTACATGGGC +AAGCAGTGGAGTCGGAGATTTTTTATCAAAATATATGGATAGGTAATCAG +GGAGAGACTGGCTCCTTTGTTACAATATATTAGGTTTTGTTCTTTAAAAT +GTTCAAATGAAGCTGAAGAGTTCCGGCTAAAAGTATATGATTTTTCAATG +ATTTTTCAAAAATTTCAAGGTATAACTCTGAAACTAAAATTTAAAAAAGA +AACTAAATTGGATTTTAATGTTAGTTAGTTTATTAACAGAAAGAGCAGTA +TTTTTTGATAATTGTAACCTGAAAACTCTATTTTTCTAGTTTCGTGAAGT +AAAAATGTTTTATTATGTGACATTTATTGAAATTTAATTATAATACACTG +TTAGAAATATTTTATTATCTAAAAAAGTAAATTGGATTATAATGTTAATT +ATTTTACTATCAAAAAGATCAGTATTTTGTGATAGTTTTAACCTAAAAAC +ATTTCTGAAGATCGTTTTTTGTGAGAAAAAATTATTTTAATATGTGTCAT +TTAAAGCAACTTTTAAAAAATTGCGGTTTAGAAATGTTCAGCTATCAAAA +AAAAGTACATTGGATTTTGGTGCCAGTCAATTTATCAACAGAAAAAGTGG +TCCTAAAATAATTTCCAAACTTATTAATGGTGGTAGCATTAAAAAACACT +TTTTTTTGGATTTTTTGAAATGAATAGTGTATTTACAGAGACAATGGTAG +ATCAACCTAAAAGAACAAAAAATTTGCAATTTTTCCAGGTAGGACACTTT +TTTGCTACTCGAATATAACTAACCTAAAATAATTTCCAAAAGTTTCAATG +GTGGTAGCACAAAAAAAAACAATTTTTTTGATTTTTGAAATGAATAGTGT +AGTTACAAAGACGGTGGTACATTGACCTAAAAAAACGAAAAATTTACTAC +TTTTTCAGGTAGGACACTTTTTTGCTACTCGAATATAACTAACCTAAAAT +AATTTCCAAACGTTTTAATGGTGGTAGAATGTAAAATAACTTGTTTTTTT +TTGGTTTTTTGAAATGAATAGTGTAGTTACAGAGACAATGGTACATTGGC +CTGAAAGAACAAAAAATTTGCTATTTTTCCATTTTGACCAAAACTATTGG +TTTTGTCCCCAAAAAATTAGTAAAATGACCCACAATCCAGTTATTTTGCT +GTTTAAGCAGACACACTACACGGAATTATTTTCAGAAACCAGATGTATGT +TAAGATTTTAGTAGTTTCGGTGCTGCAAAAACCATCAAAAAATACCAAAT +TTTTCGGCGTTTGTGAAGCACGGCAATTTTTGAGATTTGCCGCACACCCC +AGGTACAGAGACAATTTTATATCGACGTGAACGAACAAAAAATTTGCTAT +TTTCTCAGGTAGGCCACTTTTTTGCTGCTCTAATTTCACACACCTAAAAT +AATTTTCAAATGTTCATCCTACCCTTATATGTAGTAAGAAGATTTCAAAT +TCAAATTTTCATGCATCAACTCGTCCCCACCGTTTTTGTTTCCCTGGCTG +ACTCATCTGACCTTGTCACCCCACGTGTGTTTGTCTTTGTGCCCCCTCTC +GTGCTCACCTTGTTCCAAATTCTGTGAAAACTCATCTCGAAGGCCATTTT +CTTCGTTTATGAGTTTTGAAAAAAAAACGTTCAGACAACTGCAAATGACC +TCCCCGGCGTCGAGAATCGGTGATAACCTTGTACTTCTTAGATGAGACCA +GATACAAAGTGCACCAAAAAATTCAAATTCGCTTGAGAAGCGCTGGCGAG +AGATTCGAAGCGAAAACGAGTTGATTGACAATCGGAACATATACACACAC +CAGAAGACAAAGTGGGGGAAGAAAGGAAACAAAAAAGATAGAGAGGAAGG +AGATTTTGAAAAACGACAATCTCTCTGTGTGTGTGGGTGACAGGTGAAAA +AGTGAGAGTGAGAAAAACGTGGTGGGTACTGTATTGATGAACGATCAGAC +CAAGTTGCATTCAAATTTCTTTGATTGGATTGTTTCCTGATCGGTTTGGT +AGAAGGTGAAGTTGGATTTTGTTCACTGAAGTTATTGGATTTCGAGACAT +GAGCAAGCTAGGTTCAGGATGACTGTAGTGGCCGGCTAACTTTCCGTACA +CCTTTGGCCGACTAGTGAGTGCAACCAGGGCTAGTAAGGAGGTACATCCT +GGTTACCGTAAGCTTATTAAAATTCTGAAAACACCCTACAAAAACTGATA +TTTGTAAAGTTCTCCAAAACAGGTGCTAAAACTTCTGAGGCAAGAGTAGG +CACTTGGAGTCAGAATGTCTTATTTCGATTTGATCTACAAAAAACGCGGG +AGTTGAGACGCAGAAATCTCATCTGATTTCGCATGTTTAAGAGCGTGCTG +ACGTCACAATTTTTCTGGAAAAATATTCCCGCATTGTTTGTAGATCAAAC +TGTAATGAGACAGCCTGGCACCACGTGGGTAGGTGTCGGGATGCACGTGG +TGTCAGAGTGTCTCATTTCAGCTTGATCTACGTAGATCAACAAAAAAAAA +TGCGGGAGAAGAGACGCAGAGTTCTCAACTGATTTTGCATAGTTAAGCTC +GCGCTGACGTCACATTTTTTTTGCAAAAAATTCCCGCATTTTTTGTAGAT +CAAACCGTAATGGGACACCCTGGCACCACGTGGGGATGCATTAGTATGAT +TACTGTAGATAAACCTTGAACAATATATATACATTAATTTCGTAATGCTT +GAAACTTGGACCCAAAAACTATCTGTAACTAGAAAATCTGCAAAAATGAG +TTTGCGACTTAAAGCTGGAAGTATACAAGTTGCGCAAAGACCTTTCCAGT +GGCTTCAGCTAGCAACAAAAAAATTTGTAAATTTGCCGGTCCCCACACCA +CATCAAACGTGCAAGACGGGCAACTTGGTACATCCAGTTCACCTGCACTC +CAACTACTTCCCAGAACGCCACATAGTTGAATTATTACCCAACTTGGTAC +ATTATTTTGTCGACTCGACACACCATCACCCCACCATAAACCCCTGCAAA +TAAGGAAGCCGATCGCTATCTACTCATCTTTAGGGACCTTTTTTGCCGCT +TTTTATTGATTTGAACAAAATCTCAGCAGAGCAGTCAAAAATTGCCAATA +TTCCAATTTTTCAGTTGCCAAAGATTTTAGAGTTTCAATACCTACTAAAT +CCTCCCGTTCCAGCCATCCGTTCTTGATATTCTCTCCATAAATTTTCGCT +TATCTCCTCTCTTGTAAAACTAACGTTCACTTATCCACATAATAAATACA +ATAAATGTATTATATACATATATATTATATATATATATATATATATATAT +ATATATATATATATATATATATATATATATGTATATATATATCTCAAAAA +ATCAAACAGGATCTCTCTTTTCCTCCAGGAGAAAAAGAAGATGCCGTTTT +GCAGCCAACAATACTCTCACTCTCAATACACGACGCGACGACGTGGCATC +CCTCCCCCCATCCTGCCTTTCTTCCCCGTTTCTCCTGTGTCATCGAAATT +TCTAGGGCAGCAGCACACCGGATTGGTTGGCATGTGAAGCCGACGTGGAT +CGTGATGGTGATGATGTGGCGGATTGTGATAGATCGTGTTTTTTATCCGG +CGATTACTGCGAGAATTGTCTGAAAGAGTGGCAGGGCCTGGCGCCTGTCT +TTCGGCTCTTTTCAGCATTTTGACGTGAATTTCCAAATTTCTAATTTTCT +CATTTCTATAAATTTGCTGAAAATCAATCAAAGAAATAAAAAAAAAGTTC +ACTCATGTTTTAGCATACGGCGCGAGAGGCAGGCGGAAATCGCCTTAAGG +TCAGGCAGGCAGGCAGGCGTTTAACGCCTACATGGAAGCCCTATAGCACA +CATCTATCTGAAACTGGGAATGTTGTTCCGAAGTGCATTGGAGTGCCTGA +AATTATACAATGTTTGTTCTAATTTATCATTTACTGTATATAAAGCGCTT +ATTCCGTGTGTCCATAGTTGGTAGTCTATGTAGTCTGAAGTTTTGGCTTC +TGGAAGGATAGTGAGTTGGGGTTAGTGTAGGGATATGGTCGGGGAACTGT +AGTGGTACAATAGCGGTACGGTAGCAGTACTGTAAGATTATGGTACTTTC +AGAAAAAAAAGTTTTCAGCCCCAGAAGTCGGGGTCCGTGCCGGAGGAGCG +GACAACGGCTGGTTATCAATAAAGAATACCAACATTTTATCACAGATCCG +GTTACCGCTAGACAAGAAGGTAAAAATTCGCATTCTGAGAAGGACTACTG +TAGCAGGTGTTTAGCGTGTGTCCGAGTAGATGTGGCGACTCTTAATTTAA +GTTGTAGTTTCCTGGTGTCCCCTAATCGCGAACTTCACGATAATTGTAAA +TATTTTAGTGTGGCCTATGTTTACAGGTTTTACGGACAGCCTAGCCCGAG +AAAAACTCTGGAAAAAAATCCCAAAGCTCTTATCCAAAACTACCAAAGTA +TTCTATGCAATTCCCTTTTTGCATTTCCTCACCCCGCCTAATAAGGCATG +TTGTTTACCGCCGACTTTCCGCAATAATCTATTCTCGCAATCATGTGATT +TACCTGACGAATCGAAAGTATACGGTAACCTTCACATTTGGAAGAGGAGA +AAGGAATTCGTTGGAGCCTTGACCCATTCTCCCCACAGGCATAATTCAAA +AAAATATTCACATCAAGAATGCGGATTTGCCACAACCCAACGGGTTCTCC +CATCCAGCATCTCTACCTTTGCCGAGGCAGAAACTGAGGACCGATCTCGA +TCTGCCGCCGCGTTCCGACAAATGTAATAGCAGCCCCCCGCGCGATAGCT +TTTCACTTTTTCTTCTCTTTCTGGCTACTGCTGCTGCCTCCTCCTGCGCA +AGGATGATGCTGCTAGGATGATACCCTACGAGATTACGGAACTATCCGAT +AAATTAGCTTGATGGAGACTAGAGAGATAGTCCCGAAGCTCTGAAGGAAC +CTGATCTTGTTACAGTCTTGGAACCGAACAGCTGATTGCGTCGTCGTATT +ATCGTTATTCATTTCGTAAATAGATTTTCTCTAGGATTGATTCCCGGTTG +AGCCACGTCACTGTCCGAGAACATTCCGGAATGTTATGCATATGTTCTTG +TAAATAACCTTTCTCCTTCCTCCGGCCGGCCAACTACTTTCATTTCTTGA +TGCGTCGAGATACGATATCCAAGGCCATCTTTCAAAATCGCAAGTTATCC +ATCTTTTTTCGCTGATGACTCTCTCTCTCTCTACTCCTTCGCCCATCTCG +TCTTCAGAATCACCTACCGCAAAACAATTGAATAAGTGAGTGTGGAAGTC +ACGTCATGAGCGCGACGAAAAGAGAGAAAGAGAGAGAGAGAGAGAGAAGT +GCCGAAGACGTCGGAAGAGAAAAGCTGGAGGAACCAGCGGCTGGATCGTC +GTTTGTTGATGATGCCTCCTGCCTGCCATTGTTATTCGATATTCCGATAT +TCGATTCTTTTTTGCCGCCGCCGCCCAAGAGGAGAGGAGAATCAGAGAAG +CTTGCGCGCTCCCTATCAAAAAAAAAAGATTATCAAATTTGAAGCAGCAG +AAGCTGGGAAATGGAAATAATAGCGGATAAACAAAGAGAGCGAAATGTTT +TGGGCAATAAATTTGTAGTTTGATGATAAGAGTGGCATTTTGATATGAGG +AAGCTTGCAGAATCTAGTGGTGAACAGGAAGCTTTCGCTATGGAGCAAAA +TGGATTCCGTCATTTTTCTTAAAGAATCGGAGTCGAGATGAAACACCCAG +CCGGAGCTGAAAAATTATTCTGCTGAAAAATCGAGGTGCTTGAAGTACCA +GGGCGTTATACAAAAGATCCAGGGATCCTAGTTCTGCAAAAAAAATTTCT +GCATAATGAAATGGAGAACAGGGCGGTGCGGCAACCAAGATTTTCGGCAA +CCGGCATTTGCCGAAGTTGCGGAACCCAAAACATTTTGGTAACCGGCAAT +TGCCGAAGTTGCCGAATTCAAAAAATTTCGGCAACCGGCATTTGCCGAAG +TTTCCGAATTCAAAAAATTTCGGTAACCGGTTGCCGCACAGCTCTGATGG +AGAACCCGGTGGTCAGCTCAGAGTTTGGATCACCACAACCCAGAAATACC +ATCTTTCAGTGCCTCATACGTAGAAACACTCTAGCTCAAAGTGCCCCTGA +GGCCCTGGGATCTATCCTTACCTGGAAAACTGTGTAAAATTTCGAATATT +CACAGATCCTAGGTTCGTAGTTTCACAAAATGTTCCCACTCTGCCTTCGG +ATCCCCAGGACGCATTGCTACAATATTTTGCACTTGGTACAGTACTCAGC +TTTCCCTTTTTGCACCAAAAAACATTATTGATCCTTACGATTAGCGTCCT +AGATAGGCTACAAGGCCATCGAGATCTCAAATATGCAAATTCTTAGGAAA +GAAAGTGATGTTTCATCATCTTCTTGGATTAAAAATTTCCGAGGAAAAAC +ATGGCAAAAATCAGGTTGATCGTGAAACTCGTCGGGGGCTCCTCTCACTT +CTTCCCCATCTTCATCTCTCCTTCTCTTTCCCGATCCGATCTTTTTTCCT +TTCTTCCATTTTTTCTCGTTTTTCCTTTCCATTTTTTCTTCTCCTTCTTG +TGTTTGATTATCCATCCTCCTTGCCCTTTCTCCTTGTTTCATTTTTCTTT +ATTCATTCGGATGGAATAGAGATATGGTTCCGTAAATTCATTCCAATACT +AGAAGAATTAGTAAGACATTCGTAGGGGGGAAAATTCCGCGCAGAAAGCG +ACAGGAGGTTCGGGATTGGGTAATCGTCGGAAAAATGAAAAATCGCGCGC +GCCCGCCCGCGCAGATGGGATATATACTAAATCACATGGGCAGCGACATG +ATATACGATGGATTGCGTGATCGATAGGCTTTTCAAGGAGGTACATTAGC +ACTGGTGGGCGTCGGGATCCTTGAAGGAACAACGATCTTTGAAGGAGATG +ACGAGGATGTTGTGAAATTTAATTGTGATATCATTCTATTATGTAATCCC +TGGCCTAGAATATACATCATCTTTTAGAATTCTGGTCGGCTAGATGTTTT +CGGGAAGTGCTTCTAAAGGATCGGCGCTGCCATGTATGTAGGAAGTGCTT +ATGCCAACCCCAATCATCTTCTCAATCTACTCCTCAGAAGTTCAGTTCTG +CCAATCCGCACGCTCCACCTTCGTCGCCTATCCGTTTCTCATGCGAGTCT +CGGGTCAAGGCAAGTGTGCGTGTCCTTCAGTCGTGAAGTCCTATTCATTT +ATTTTTGCTGCCAAAGTCCGAACAGTTTTTTCTAGCCGTGTCGGCAAAAG +GGTTCTTATTGCGAATTCACCTCCTCCCCACTCGAGAAATCGCCCCCCCG +CCGTCCTTGGTAAAACTGACCTAGAAAAATAAAAACAACACAAAGCGCCT +CCCGCATCATCACGCGTATATATGTATATATATAAGATGGTAGGCGGGAA +GAGGAATCGACGCAATATCGACTGAAGGTTGCGCAATCGAGATGGCTCTT +CCCGGCACGGATACCTCCTCCTCGCGTACCAGGCACCCGCATATAGCTAA +AGTTCTCCGCCCATTTCGTTACTTTTTTGTGCTTCCCATATCATCGCAGC +AGCGCTTATGCCATTGCGCCCGACCCGATCCAACTTCTTATTCTTGTTCC +TTAGCCTTCTCCCCCTCCCATGTCCTCCCGATATCCAAAAAGTGGGAGGA +GCATGCCATAGTGAGAGGGCGGGGCCGGGACACACACAAGGCTGGCCCCG +AGAAAACGAACAACACTTATGCCGAGGACAGTCTCGACAGTTGGTGGTCA +CCCCACCTGCGCCTTGATTACCCCGCCCGTCCGCGCCCGCCGGGCTAAAG +TATTTTGTTTGCCATTCATGTTCCTCATTCGACGTTCATCATGCTTCTGT +TATGCTTCTTGGTGTTGGTCCGGTTCCTTTCTCTCTCTCTCTCTTTCTTC +CTTGTGGATCAGATGCCATTCCGCCTTTTTGCTAGATAAGCGCATATTCA +TCTCACTCTTCTTTGTTTTCAATTCAGCATTCTTTATATATCCAATATCC +TACATCCTATATCCTCGTTCTCTCCTCATTTTCATTCATATGCCGATCCA +TTTGGTACTGGTGGTGTCGTTCTTCTTAGTTTCGCTTTCCAATTCTTTTC +TAGACAATTCCTTCTATTTCCAGAAACTTTTTTCTACACAATGCTCCCAG +ACAGCCCATCCCCACGCGCTGCCCTTGCTCTCTCCGATCTTCAGCCACAA +ACCGGCGCCTCAACGTTCTCAATTGGCAGTGGATCAGGCAACTGGTAAGT +CGAGTTCTTATGTAACTAGTAGGATGGTAGACATCGAGATTAACGATGTC +TGGCATTCGTTACGTAACGAACGGGTTCTCCCGCCGACCATCGAAGCGCT +TAAGCGCCGAGATTCTCGGCTTCATCGCACCCCGGTCTAGCAAGTTTTCC +AATCCATCCCAAATTACAGGTCGACAAGAGGTGTTGGTGGAGTTAATGGT +GATTACATGGACAAATCCGGCGGAGGAATGTTCGGAAACAGCAGAAACAA +CGTGAGTTATAAAAATATCTGGGGGGGGGGGGGGGGGGGGAAGTGTTGTT +CTAGGCCAGGGACATTGAGAACCGCGTGATGAAGAGTACTTTTATCCGAA +TTAAATCATAGGCAACGAAAACAAGAATCAGGTTCTTGTGCTTTGCACAC +CATGTCGGAATATCCGTCTCAATCAAAACGAAAAAAGCCTAAGCTGGACC +AAGTGTTAAATGCTTAAATGCCAAAAATGAACAATCTTTCAAATCACTTT +CATCTTCCTGTAAATCAGAGAATCCTGAAGCGCTGGCGCGCACACTTACG +AAAAGTGAAAGCCGATATATCAAGTTTATCACCTAGCGGGACTTCCATTG +TCTCATTGTCTCTTGGCTATCCGCCCCACTTTCCCCCCGGATCATCCGCC +CCCTTTAATCCAAGACTCTCGAACAGTTTCGCTTCATTCCAGGACCGATT +CGCATTCGGCAACAACAGCTCGTCGTCCTCATCAGCAGGCTGCTTTTCAT +CGAACAATTCGTCAGGCGGACTTTTTTCCAGTAAATAAGTTAATATGTGA +GTTTTTTTTGTGTACATTTTCTTCTTTTCAAGATCCATTAACATTTCAGA +ATGCGATCGGCAGCCGGTATTCTTATTCTAATCTCAATAATTATTCCCAG +TGTATATAGTGAACCGAAGTTGCCCGATTGCGAGCAAATACCAAAAGTCT +TGTGCTGTACCCAACGTGTCTTAGATAAATGTATGTCTGGTTGTATCGAT +TATGTCACTGAGAAATGCCCCCACAAATTGGAAAAATACGAGACGATCGA +TGAAGAGCCATCGACGAGAGCTCCAAAGAAGCAGGTGAAGCCAGCTAAGG +CAACTAGCAACAGAGTTGTCGGAGCAGTTGAAGTAGACCATGAAGCCAAG +GAGCAGTTCATCGACTCCAAGGATATCAGAAGAGCACCACGAGTCGGTGA +TGCCAAGCTTCTCAGCCAGGAGTACCCGATCACCGAGGTCACCGACGCCG +ATCTCTCCTCCGAGTGCGGAACCGAGAAGTCTCAGCCACCATTCTCACCA +TGCTTGTCCCGCAAGTCGGCCGACGACGTCTTCCTCTCCTGCTGTCGCCA +ACAGGTTCCATCCAACTGTCACAGCCTCTGCACCTACGAGCATCGTGAGC +ATGTCGCCGCTGAAACTCTGATCCAGGCGATCCAGCAAGAGCACTGCGAT +ATGAAGGTAAGAATAGTTCAATCTTCCTATTGAGTTTTTTTTTTGAGTTT +TTCCAAAATTCATTCTTTCAGTACTTCTCCAAACTGCTCTACTGTGCCAA +CCAAAACCGCGACAACCGCGCGTGCTGCTCCAACCTCGGCATGTCAAACG +CGGAACTCGGCGTCGGCGATCGTTGCCTACGTATGTGCAACATCTCCCCG +TCGGGAGACCGTGTAAGCTCTATGGAGAAGGAGGATCTCGTCTGCCTGTC +CAACTGGAACGTCATCATGTACTGTGCCAGAGGTGGTCTTCGTACCATCA +ACTAGACCATCATCCCCGTTCTCTTCTCCCGTAATAAGCTGGCTCAGGTT +GTTAATAATAATTCGCCGCTCGTCTTAATAATTTTCCATTTTCCAATCTC +GTCCCCCCTTTTCAACACTACCACATTTCTCAGTGATATTCATCTGAACC +GCCCGACATACATCAGTTCCTCATAGTACCTAACAGGGTTCAACAAACCC +ATCCACACACCGTCCCCCCACGTAACACCCCCCCCCCCCCCACTTAAGGA +CCAAGTCCTAGTTACTGAATGTGCAACATTATGGCCAGAATGCAATACTT +GTCCCATCTGAATCCATGTTATTTGATAATCTATGACAGTATTATACAAC +CCTTTTTTTTCAAAACACAAGCCCCCTTGAAAACGAACTCATTGTATGTC +AAACGGTATCCCTTATTACACGATTAATTGTGGAGTTTGAAGCGAATAAA +TCAATCAATTTCTCGTTGGGTCCCACAGCGAAATGACTATTACCGGTACA +GAGAGTGTGGATAGTTAGAGAGTGACAGACATCCGGGACCCAATGGGGCG +GGGCGCGCGGAAGAGACGATTTGTGTCGATTTACGAAATGATGACAACGA +GGAAAATTTCGTAAATCGACACAAATCGTCTCTTCCGCGCGCCCCGCCCC +ATCGGGTCCCGGATGTCTGTCGCTCTCTAACTATCTACACTCTCTGTACC +GGTAATACTATTGCAGTAATCGCAGGTTATTTCATAGCGATTTTTCATAG +CTTCACGGATTTCTGGATTCCCTCATAAATTGAAATGGAAGAGTTTTTGC +TGAACTAGGCCATTTTGGCTCTGTCATATCTGGGGTAGATTTACGGCGCG +TTGCGGTTCGATTTTAGTTGTAAAACTAAATGTATTTGTCCGTGTGGAGT +ACACGACTTTCTCACGCGTGGTCCGGCAGGCGATTATCAATAGAGCGCGA +AAAATTCAATGAGGAAGGCCAGAACTCCGTGCAGCTTTACTCGCGAATTC +AGGTGTGTGTTTTAATTGTCTTTATTCAGTTTTCTGATAATGAATATACT +TTTTTACAGAAAAACTGGAAAACTGATAAAAAAGTCCCCAGAAACTAGAT +ATTGAAATTACAGTACACTTTAAAGGCGCACACATTTTCACAGTAAACAA +AAAATTTGTCGTGCCGAGATATTTCATCCAGATTATCAGTTGTTAAAATT +TGACAACACTCATTTTGAATATTTAATGAATTCGAATGGAAAATAGAAGA +AAGCTGCCAAAAAGTGAAATTAAATTCTCAAAAACTTGATTTCCAGACTT +TTTTGGCGATTTTCGACCAATTTCAGCAGAATTTTTAGCAGAATTTTACA +AATTTTTTTATTTTAAAGCTTATTTTAATAATTTTTCTCTGAAATATATG +AATATCTTTGCTTTCGATGGATCTTCCTCAAAAGTAGACACACATTTTTA +TTTTTCTACAAAACTGTGCAAAGTTACGTCGTGGTGTTTGCGTACCTCGG +CGGGAATTTAAAGAGAAATGGCATTTTTCACTTTTCTCGCAGTTTTTCTG +ATTTTTTTTTCGTTTTTTCGTAGTTTCCTAATAAAAAATCGTTCCAATTG +TTTCCAGGTAATGGCTGGATTTGAAATTCAAAGAGTCGAGTCCAAATTCT +TCGACTTGGACGACATAATCGCCAAGTCAGACTCCACGTCTTGCACATTT +GAGATTGGAGATTTGAATCCAGGTCTGAAATCGCATCGAAAACCTAAAAA +TTCTAGTGATTTTTGTTCAGATTTCTTCCAGGAAATGCTGGGAGTTTCGA +AGCCAACTCAAAATGCAGACGGATACGGCGTTGATGCTCCATACTGGCTG +CTGGAATCCGTTAGAAGTTCATTTTCCGTGAGAATTTAGTTAGATTTGCC +CCGAATTTTAATTGAGAATTCCAGATTCAACTGCCAAAAGCTTATAGTGT +GAACATGCAAAATGTGCTGAACGCTGACAGCAAGAAATTGAATCTCTCCG +GCTTGCAGCAACACTTTTACGGCAACGGGATGCAGTTATGCCGTCTGATG +AAGGGCGAAAATCCGGACGGCGCGCTGAGCCTCGCACGATGCCTTGTCTC +CACACTTACACAGCGATTAGGAGGTATTAATTAATATAATAAAGCACTTA +TAAAATACAATTTCTGGTTTTTTTTTGTTGCAGAAATTGTGTCAACTGCA +ACCCATCTGCAAAGCAAAGGCGAGAAATTTGACAGCCTCGAGACAAAAGT +GTTCCTGGAGGGTAAACGGTGCAAAGAAGACATTGATACTTGGCTGAGAC +AAGACAATAAGTGCTCGAGCAAGAAGCGTAAGAGACTTTCGTTATAAACT +TCAAATTTCTTATGCTTGAATCTAATTTTATTTTTTTTAATTCGTCTGTA +AATATAATTCAAACCCACCATTCTGTAATAATATTTTATTTTCTATTTTT +TCACACTCATTTTTGTGTTTTATTGGTGTAATAAACCTGGTTTCATGACT +TTTTTGCAAGGAATTTTGTTGAAAAGGCTGCTGCAAAAACTTTGCCAGCA +AAAAATTTTGTGCAAGCACGCTCCATCGCACAGTTTGAACGTCGCGGGTC +GAAGTTAGATGTGCAGGTCATATAGCAAAAAGAGAAACACCCCTTTTTTT +CTCGAGAAGTTTCACCAATTTTGCGCGATTTTTCAACTATTTTTTTGCTT +TTTTGGCTTAATTTTGGCTCAGATTTTCCTCAAAAACATGAAAATCCAAT +CTAGAATAAGTAGTAATGGGTATATTCTAAGATTGTGCAAAAGTTAGCTT +GAATTTCCTCGATTAAAGCTTTCCTACCAAGAAAAATGTGTGGATATTTT +GAATTTACAAGTTTTTCATCTTTTTTTTGTAATATTCTCTTTGAAACTCC +TGTTTCTCTCAAATTTGTAAACTTTCATAAACGTTTTTTTCAGGGTTACC +ACATTAAACAATGACCGGAAGCACCGAAACTCGCCAGAAGGAAGTCAAGG +AGGTTGGTTGTTCAAAGTGACGTCTAAAATATTTAAATTTCTATATTTCA +GCCACAAGTTGACGTTTCGGATGATTCCGACAACGAGGCCGTCGAGCAAG +AGCTCACCGAGGAGCAAAGACGTGTGGCCGAGGCTGCTGGACTTGGAGAT +CACATCGACAAGCAGGCCAAGCAAAGCCGCTCCGAGAAGAAGGCCCGCAA +GCTCTTCTCCAAGCTCGGACTCAAGCAAGTGACTGGTGTCTCCCGTGTCT +GCATTCGCAAGTCGAAGAACATCCTCTTCGTCATAAACAAGCCAGACGTG +TTCAAGAGCCCAGGATCTGACACCTACATCATCTTCGGAGAAGCCAAGAT +CGAGGATCTCACCCAACACGCCCAGATGTCTGCTATTGAGAACTTGAAGC +CAACTCGTGAGGCCCCACAACTCAAGACTGTCGAAGAGGACGAGAATGAG +GATGTTGAGGTAATTCAGTAACTTAATCGGATTTATTACATTAATTGTAC +GGTTTAAGGAGGATTCCACCGGCATTGAGGAGAAGGACATCGAGCTTGTC +ATTTCCCAAGCCAACACCACCCGCAACAAGGCCATCAGGGCGCTTAAGGA +AGCTGACAATGACATCGTCAATGCCATCATGAGCCTTACCATGTAGCTTG +TTTCCTGATGACCTTGCAGATACTCTTGTTATCGTTGTATCTCTTGCTTA +TCCCGTTTTCCGTTCCAAGTAAACGTTTATCAGTCTTTTTTAACTTTTTT +GTTATGTTTAAAAAACAATTGCATCTTCGAATTGACCTACCTTTTACAGA +AAAGAACAATTAAATCACTGTTTGTGTAAAACACCCCTCTATTGATCGAG +AACTTTCACTTCTTCCAATTCTTTACTCGTATGACTGTGATTCATTTCAC +CTGCTATCACTTTATCATGACATTCCAGTTTATATCAACAGCAAATACCA +ATTGTGTGTATGTGAAAAATGCTATTGAATAGCAAGCGCGCCCCAACAAA +CACGTTTGAATGCGCGGGCGAAACGGCGTTAGATGTGCAGGTCATATGAC +AAAACGCATCGACCAGCAGCCAATGGCAAGTTACTGCGAGCTGTTATAGA +TTTTTTCACATGGTTTCCAGTGTTATCAGTTGGAAATCGATCGATAATAC +TGACTAGTAGTACTTAACATCTTCATTCCCACCGTTTCGCTGTCATTTGT +GATACGTGGATTTATTTTTCCTTTCTCGCCGACTTTTCATTTCTAAATCT +TTTCTGGAATTGCGAAATTTTCAGCCAGTTTCATGATCGAATGGCTCGTA +ATGAACCATCATCTCAGCAGCCGAGTAGTTCCGGGAGTAATGGAACTCCA +GCACAACAAAACGGGTCGGCAAAACCATCAAAAGTCACAGTAAAAGGTAA +CAATTCGTAGATTTTTTGCATCTGTTCTAATAATATTTCCCCCTCTTAAT +CATAGTCGTCAACGCGTCGTTCACCAAGGCAGCCGACTGCTATGTCGAAA +TCACGAGTGACACGTCATCGGCGGCGCCAAAAAAGACGACTGTAAAGAAG +AAGACGATGGCGCCCGAGTGGAATGAACATCTCAACGTTCATGCAAATGA +ATCTTCGACAATTTCGTTTCGTCTATTGCAAAAAGCCAAGCTATTCGATG +ACACGTGTCTAGGGATGGCGAAGCTGAAGCTTTCGAGTCTCACAAGAAAT +GAGAATGGAGAGTGTAAGTGGTTTTATTGAAATTTTCTCAAAAAATCTAT +TATTTCAGTCAAAAACGACATCAACAATATATCTTTGCTGGCCAAAGACT +CCTCGAAAATCGGAACTCTCAACATAATTTTCTCCGGATATCCAGAGCGG +AAACGAAGAAGCGCAGGAGTACGAGCTGAAACCGCCGCGTCTGCAAGTTC +AGAGGCATCCACGTCAAATGGCGTTGCCACGTCATCCTCGGCGCGGAGAC +CGGCGACAGCGAAGCGTGACACTTTGGCGGCTCCAACGGTAATCGTGACG +AGACCCATTTTGAATTATTTAATTATTCATGAAACGCTCTACTGGAGTGT +TCATAATTATTAGAGCGCGCTCGCGCGGCACCTCACGAACTCCAGAATTC +GCGAGGACAGCAGTTTTTGGCTATTTTGGCTTCTATGGAAATTATTTTTA +ATTTTTTGATTTAAAATATTGTTGAGAAGCATCATCCAAATTGAAAATGT +GTAAAATTATGAAATTTGACCGAAAACTGAAGGTTTTACAGAGAGGAGTC +ACCACGGCTTTCTTTAAAAAGTATCAGTACCGTCAGTATTTCGATTTCAG +AGTCGTAAAATATGTCATTTTGTAGAGAAACGTCTGTTTCACAAAAATCC +ATGTTTGATATTTTAATTGTTTAATTTCTAATATAAAAATATTCAAAAAA +TCAACAAGTTTACGTTAAAATCGAATTTTTCAATCGTTCAGTTTTTAATA +AGAACAATTTCATAATTTCAAACATGGATTTTTTTGAAACAGACTTTTCT +CTACAAAATGACATATTTTACGACTCTGAAATCGAAAAAACTGACGGTAC +TGATACATTTTAAAGAAAGTCGTGGTGACTCCTCTCTGTAAACCTTCAGT +TTTCGTTAAAAATAATTTCCATAGAAGCCAAAAATAGCCAAAAACTGCTG +TCCCCGCGAAACGAAATCCCGCGAATTCTGGAGTTCGTGAGGTGCCGCGC +GAGCGCGCTCTAATAATTATGAACACTAGAGGAGAGCGTGAATGAGCGTT +TTTTATTCTTTTCTCTGCATTTTTAATGCTACAGAATCATACACAAAATG +TTGTCAAATACATGCATTACTCTACTACTCTTAATGTTTACTTTTCATTT +GCAGAGTACCGCAGCGGCGGCAGCAGCAGCAACAGCAGGCGGCACCCCGG +CCGCCGGAGCAGAAGAACAGCTTCCCGATGGATGGGAGATGCGTTTCGAT +CAATACGGACGCAAGTACTACGTGGATCACACCACCAAGAGCACCACGTG +GGAACGCCCGTCTACTCAGCCATTGCCACAGGGATGGGAAATGCGAAGAG +ATCCGAGAGGAAGAGTGAGTTTTCCGGCGGAAAAAGCAGATTTAGCACGA +GAAAAGCGTTTCTGATTATATTTTTGATGCGAAAATCATCAAAATTAAAA +ATATCTACCGTAGCCGCGGATACCTGGACCAAAATGCCGAAAAAAGTGAC +CTGATAAATTATTTTAAGGCTAAAATCTTGATTTTTACATAATTAGTGTC +TTATTTTTGTTGATTTCTTGTCAAATTTTTGTAATTGCATCGAAATAGGC +CAAAAATAAAGTAAAAATCAACTTCCAACACAGAAAAACTGACAAAATTG +AAGATTTTTGCTGAATTCAGGCAATTTTTCGTAATTTTGATCCTCCATAA +TTTTTTTTTTCGAGAAAATTTTGAAATTTTTTCTTTAAATACGGCCTGAA +AATTAGGAAATTATAACGACGGATAAAAAATTCTGATTTTCTTTATTTTA +ACCAAGGTCTCCAATTATTTGATAATCGAAAAAAAAAAAACTTTCCAGTG +ATTTTTACTTGAAAAATGTCTAAAAATTCACGCCAGGTGCACAATCCATT +TTCAGGTGTATTACGTGGATCACAACACGCGCACGACCACCTGGCAACGA +CCGACAGCCGATATGCTTGAAGCACACGAACAATGGCAATCGGGAAGAGA +TCAGGCGATGCTTCAATGGGAACAACGTTTCCTTCTCCAGCAGAACAACT +TTAGCGCCGACGATCCACTCGGACCATTGCCCGAAGGATGGGAGAAGCGT +CAGGATCCGAATACGTCGAGAATGTACTTTGTGAATCATGTAAATAGAAC +GACACAATGGGAAGATCCGAGAACACAGGGGTATGTGAAAATTTTCAATT +TTCCAATAATATTTCTATCAAAAATCACAGTTTTAATGTTTTAAAAGTTT +CAGAGGCTCCGACCAACCTCTTCCGGATGGTTGGGAAATGCGATTCACCG +AGCAAGGCGTTCCATTCTTCATCGATCACCAGTCTAAAACCACCACCTAT +AATGATCCAAGAACCGGAAAACCCGTCGGCCCGCTCGGCGTCGTCGGTGT +TCAAATGGCCATGGAGAAGAGTTTCCGGTGGAAAATTGCACAATTCAGAT +ATTTATGCTTGGTAAGGGAGGGCGAGAAATTCTTTGATTTTAGCTATAAA +TTGATGTAAATTTCAGTCAAACAGTGTGCCTAATCATGTCAAAATCACAG +TATCCCGTAATAACGTGTTCGAAGACTCATTCCAAGAAATTATGCGTAAA +AATGCAGTCGATCTACGCCGGCGGCTGTACATTCAATTCCGAGGCGAAGA +GGGTCTCGACTATGGAGGTGTCGCCAGAGAATGGTTCTTCCTGCTGTCGC +ACGAAGTGTTGAATCCAATGTATTGCCTATTCATGTATGCTGGTAATAAC +AATTATAGTCTTCAAATCAATCCAGCTTCATTTGTTAACCCGGATCATCT +TAAGTATTTCGAGTATATTGGACGATTCATTGCCATGGTGAGTGTTTTTT +TTTAATTGAAAATCAGTTGAAAATTGGATGAAAAATTGCGAAATCGAGAG +AAAATCGAGTTTTCCGCTTTTTACAATTGAATTTTAAAATTTTAAACGTT +AAATTTTGCAGAAAATTCCAAAAAAAAGCACTTGGATCTAAAATTTTTGT +TTTTTGATGAAGGAAATCCTTAAATATCGATTTTTTTTATTTTCAGCTCA +AAAAACCTGGAAATTTCGATGATCTCAAATTTTCAGATCAATATATTTCA +TTTTCTCCTAAAAATGTTATTTTTATTTAAACAAATAGTTTTTCTTAGAA +AATTCCTTTATTTTCAAATTTCCAGGCGCTATTCCACGGGAAATTCATCT +ACAGCGGTTTCACGATGCCATTCTACAAAAAGATGCTCAACAAGAAGATT +GTTTTAAAGGACATTGAACAAGTCGATTCGGAAATTTATAATTCATTGAT +GTGGATCAAGGATAACAATATCGATGAATGCGATATGGAGCTCTATTTTG +TTGCCGATTACGAGCTGCTCGGCGAGCTCAAGACTTATGAGCTTAAGGAG +GGCGGTACAGAGATTGCTGTTACCGAGGAGAATAAGGTGAGATTTTGGAT +TAGCTAGAGCTTATAAAAATAATTTTTAAATAAAATAATTTAATTTAAAA +AATCCCAATTTTCCAGCTTGAATACATCGAACTGCTCGTTGAGTGGCGCT +TCAATCGCGGTGTCGAACAACAGACAAAAGCCTTCTTCACCGGCTTCAAC +TCGGTCTTCCCGTTGGAATGGATGCAGTATTTCGATGAAAGAGAGCTCGA +GCTGTTGCTCTGCGGAATGCAGGACGTTGATGTGGACGATTGGCAGAGAA +ATACTGTCTACAGACATTATGCTCCACAGAGCAAGCAGGTAGGGGAGAAC +ATTTGATTAAAACTTCTTTTTTTTTAATTAAAAAATACATTTATAGGTAA +CCTGGTTCTGGCAATGGGTTCGAAGTCTGGACCAAGAAAAACGTGCCCGG +CTCCTACAATTCGTCACAGGAACGTGCCGTGTGCCAGTCGGTGGATTTTC +CGAGCTGATGGGCTCGACGGGACCACAACTATTCTGTATCGAGCGTGTCG +GCAAGGAGAACTGGCTCCCACGGTCGCATACGTGCTTCAATCGACTCGAC +TTGCCGCCATACAGAAGCTACGATCAGCTCGTCGAGAAGTTGAGCATGGC +GATCGAGATGACGGAAGGATTTGGAAACGAGTAGTCTCCCGTTGTTTTTT +TTTGGTTTTGCTGGCCGCCTAATTATTGTATAACCCTCATATTTCTTCTC +ACCCACACCCCATTGATTTTCCTTTTTTTTCTCTCCATCAATTAATGTTT +CTTTTTTTCGAATTTGTGTGATAATTTTCGTGTTGTGATACCACTTGCTT +AGGTTCTCTCTCTCTCTTTCCTTTCCTTCTGGGTATGTACCTATATTTAG +AATATAGACAAAGCATCTAGTTTTTTTGGATTTAATTTCCAAATTTCCCG +TTTAATTCCAACAACAAAAAAACAATTCCACCACTTTTCAAATATTTTTT +TTGTGTCCATTGCTTCATTGCTTTTCTTCTTCTCAACCATTTCAACCACC +ACCACCCAATCTGCGCCTTATTCTTACTTGGTCCTTGTCATTCTTAGTTC +CAGTTTTTTTCACGGAAGCAGCTCTCGATTATTAATTCAAATGCATCCCC +CCAACCAATCCGTCACCCCCCGATTAGAACAATTTCTACTTTTTTTTTTG +AAAACAAAAAAAAACACAATTCCTCGATTTGGTTGTAATGAATTTAATTT +TTTAAATTTTGAGCCTTTTTTGTTGTTTTAGGTTTTCTTAACTTTCAGAA +TTTCCATGCGGAACACACGGAGAGCAGAAGATCAATATTTTGAACCCTGC +AGGAGAAGGACGGGACCCTTTGGTCACTCATGTCTCGGCTGTCTGCGTCT +CTCCTCTCTCTCTGCACCAGCGGAGAGGATGGATAGCCTCATTCGTTTTA +TTTCGGACTTTCGATTTTTCTTATTGCTCCACGTTTTAGCTTTTATCAGA +TTCGGGGAGCTCTTGCTTTTTTCTTGATTTTTTCGTAAAGTGTTCTTGGG +TCCCGCAGCGAAAATTAACTTTAAAATGATTTTTTAAAAACTTTCTAAAA +ATTCATTTTTTTTTCCATTTTACGACTAGAAATTTCGAAATTTGAAAAAA +AAAACCGTGTTGCAAATGCGCTCCAGCGTACAAAACAAAACCGCCACCAA +AAAATTTAAATTACTGAAAAAAACGATGAAATTTTGAATTTGTTTTGCCA +TTTTCCGGCAATGATTTTTTAAATAAAAAAAACTGTACAACAAATGCGCT +CCAGCGAACTAACCTTCAAATTACCGAAAAAAATTATAAAAATTTGAATA +TTTCCGATTAACCCAAGAAAAGAAAAATTCAATGATTTTCTTGAAAAAAG +TTATTTTTTTCTCAATTTTTCGTCAATAATACTCAAAATTTGAAGAAAAA +TTGTGTAGCAAGCGCGCTCTAGCGAACCAAACAAAATGTCTCCATTGAAG +CGTTTCACGAGGTTCTGGCCTACCTCATTGAATTTTTCGCGCTCCATTGA +CAATCGCCCGCCGATAACGCGTGGGAAAGTCGTGTACTCCACACGGACAA +ATACATTTAGTTTTACTACAAATATCGAGCCGCGACGCGACACGCAACGC +GCCGTAAATCTACCCCAGATATGGCCGAGCCAAAATGGCCTAGTTCGGCA +AAAACTCTTCCATTTCAATTCATGAGGGAAGCCAGAAATCCGTGATCCAA +GTAAAAAAAATCCCAAAAATTTCAATTTGCAAGGGCGCTCCATTGAAAAC +TGTGGCGCCGATCGCAACTCACGGTCGAATTTGAATTTTTAGTTGAAAAA +AAAACACCAATTTGAACTGAAAATTTGAATTTTCAATTTTTTCCCTAAAA +TAAATTGTTCAGAGTTTCGCTGTCGAATTGTTGATACCCGCTCGTCAGAA +TTGGAAATTGAGAAATTGAGAGAGAATTAGAGAAGGAGAGGAAGAGGAAC +TGCTCACTGGTCCCCTCACTCCATCCGAAATTAGGCACTTTTTGCTCCGG +CGGCACTAGAAGACGAAGAAAAAACGACGAGCAGAACACAATCAATTTCG +TCTTCTTTTTTATTTTTTTTTGGTTTTTTCTTGTTGGTACCACGGATTTC +TGGCTTCCCTCATAAATTGAAATGGAAGAGTTTTTGCCGAAATAGGCCAT +TTTGGCTCGGCCATATCTGGGGTAGACTAACGGCGCGTTGCGTGTCGCGT +CGCGGCTCGATTTTAGTTGTAAAACTAAATGTGATTTGTCCGTGTGGAGT +ACACGACTTTCCCACGCGTTGTCCGGCGGCCGATTGTCAAAGGAGCGCGA +AAAATTAAATGAGGAAGGCCAGAACCCCGTGGTAAAACATGGTGCATCAA +CGCAAAAATTTTTCATTTTTTGGAAAAACTCAATTGTTTTTTTTTCGCGT +CGGGACCACCAAACCAGAGCTCGTTTACTAAATTGAATTTCCAAAAAAAA +AAAAATTTCGCTCTGTTCAAAATTCGAAATTCAGTTTTCTTTCCCTAAAA +CCTAATAAAATGATCTTGGCACAATGCTCACTGTGAGCTTTGGGTCTAGA +ACGATGGCCTAGAAATGTTGAGATTTCCTCTTCCAGCGCCCTTGCCAATA +TGACCTAGAAATTTCAAATTAGTATAACTCGGCCATTTTCCATCCGTTTT +CGCCAAAACTACACCATTATAACATTTAAAACTTACTTTTCAATATGATG +ATAATACTTTTCCAGTGGAAGAGTTTTCCGCATTTCTAAGCCACCAAAAC +CTCTCCTCCCGACGTTTTATCAAACAAATGATATCACTGTGATTTGTGTT +GTAAGTTGCGCGCATGATTGCACTTGCGCAATTAATTAAGACAATTACTC +AAAATTTTGATCGAATTAACCCCATGTACATATAAAATACAAGATTTTTG +TGTATTGTTCTTCAAAGTTTTTTGTCGTATTTATATAGAAGCAGTGTACA +CCTAAATTTGGCTTATTACGACCTTTTTTTCCAAGGAAAATACTCATTTT +TAGGGTTATAAACCCCTTGATTGATACGTGGCCTAGAAAACTGCAAGCGC +TTTTTCCTGGAAGTTTTAGGCCACCAGTTAGAGTCTTGCAAAGACGGACT +AGTTCTCACATGACCCAGAAAGTCTTAGTCCATCACGTATTTCTTACGAC +GCCTAGAAATGCAAATCTTCGGCCACCAATTTTCATAGACATTCTAGGCC +ACCCTTTTTGACGTGGCCTAGAATCTTTAACAAAATTTGTAATGAAAATC +CTAGGCCACCATTCAGTTAGCTCTCATTTTTGATACTTCGCCTAGATTTT +TAACACGTGGCCTAGATTTCTATTTTAACACGGGGCTTAGATTTTTATTT +TAACAAGTGGCCTAGGTTTTTGCTACTAGGCCTAGATTTTTTACATGTGA +CCTAGATTTTTATTATAGCACCTGACCTAGATTGTTGGCATTTGGCCTAG +ATTTCTGTCATGTGACCTAGATTTTTTAATGCACCAAAAATTCTCCATAC +AAATTTAACTCCTACACTCTAATTTGTAATCAGAACCTTCGATAAGAAGA +ACATGGAGCTACTGCGGTGCTCAAATTCCGAACAAAAAACGGCTGAAAAA +CTGAGGTATACGTGGTTTTTTTTCGAAACTGATAAAAGTCAGCATAAATC +ACGATAAACTGAACGTCCTTTGGCCAAGTTTAGAGAAACCTAGGCCACGG +GTAGTGGTGGCCGAATTTTAAAAAAACTGGGCCACGAGGTTTACGTGGTG +TCAAATTGCCCCATTTTGGTTTGATCTTCGAAAAATGCGGGAGACGAGAC +GCAGACTTTTCAACTGATTTCGCATGGTTAAGAACGTGCTGATGTCATTT +TTTTCCGTGGAAAAATTCCCGCATTTTTTGTATATCAAACCACAACGAGA +CACTCTAACACCACCGTCCGGCCGTTCAAACGAAAATTTAGGCCACGGCC +ACTAGGGTGAAGTGGAATGCCCTACCCTTCTCTACAAAATTCATTGGAGA +AACCTAGGCCATGCTCAAAGAAACAGTGGCCGAGAAAGGAAAAACTAGGC +CGCGTTCGCTTTGTACCTCTCTTATAAAACACTGTCTGTTAGTTCATAAA +TCAGAGTCTGCCCCCTATCACTACTCTCTCATTTACCTGCCCCTCTTAAC +AAACAATCAACCCCCCCCCCCCCTCTAAATCGACTACTTGTTCCCCGTTG +TACCTGTCTGCGTCTAGCTATTTCTGTTAAATTTTTGGAACGAAAAAGTG +GTATGTGAATGTACGAAACAAAAATAATAATCAATTGAATACAATTTTTG +CCCCCCCCCCCCCCCCCCCTCCACCCCGCTTGCCTGTCTCTAACCGGTTT +CCCCTTTTTCACCTCAATCAGCCCCCCCCCCCCCCCCCCCCCCCCAATTT +CATTTGACTGTACATTTTCCTTTACCTATCTGCGTATCTACACAATTTTT +GTATTTTTTCCTTTTATTTTTCTAATTATAAACCCTGCAATTTGCAAGAA +AAAATCTCTAAAACGCTTGGCCCCTTACCCGGAGTGCGACCGTGGCCTAG +AAATTTATATTTCTTATAAGACCCCCCGGCTCTTCCAATTTTTCATTTTT +TTTCTTTGAAAGCCTAAATTTTCATTTTTTCTTAGAGATCAATATATTAT +GGGTTAGTAAAAAATTTCAAAAACAAGCTCCCCGTGGGCGTGGAAGAGTT +TTCCAAATTTCTAGGCCATACTTTTCGAAGGCGTTGGGGTACGCTCGCAC +CCTAGTACTAAAAATTGTAAATTATAAAATTATCATAAAATTGGCTCAAA +GCATTTGAAAATAATAAAAAAAATTTTAGAAAAAAAAACACGAAAAAAAC +CCCTATTTTGAACATGGTTCATCGACCGGGACCTATATACTTTGAAAGCT +TATATCTCGCTTCATGTTTGTTTTATCAAAAATTTTTCAACCAACAAAGT +GTTTATTATTTCTTTTTCTATATTTTTGTAATTAAAAACTTTTTGATAGC +TTCAAAAGTAACTGAGATACATGTTGTCAAACAGAGCAAACTTATAGCTT +AGCCCAATTATTTATTTTTTGCTGTGTAACATTTCTTGTATAAACTTTTA +AAGTTTACGGTTTTTTTAAATTTCTAAAAAAAATTATTGACACTTTAAAG +GGAGGTCATGTGGAGATAGCCTGTACAAATAAAACTGATGAACTAGGACG +AACCGAAATTCATAAACCATTATTTACACAGGTGATTCTTGCCTTTTTTG +GAGGGTTAAAAAGGTTAAAAATTATTTAAAGCTTGGAATGAGCATTTGTG +CGGCCGAGTTTTTATTTTCTAGGCCATAATTTTTAAAACAATGGCCTAGA +AGCACAAATTTCTAAGTAATTTGAATTTCCCGCCAAAAATTTTTTTTTCC +ATAAAATTTAAATTTCCCGTCGAAAATTTTTTTCGGAAAATTTGTATTTC +CCGCCAAAAGATTTTTTGTCTCAAAAAATTTGAATTTCCCGCCAAAATGT +TTTCTCAGAAAATTTAAATTTCCCGCCAAAATATTTTTTGTCTCAAAAAA +TTTGAATTTCCCACCAAAAATTTTATCCCAAATTTTATCGAACATTTGGT +GGCCGAATTTCCATTTTCTAGGCCACCCTCAGTTAAATCGTCAAATAAGT +TGACCTAATTAAATTAAAAATTAACAATTTGTAATGTCTCCGACCAAAGT +TTCATAATTGTATAGATCATCATGGTGGGAGGCGGGGTAGCACTTATGAG +TGAACTTACCGGTTGACCGCCCGTCTATACATAGTAGCCAACACCCGACC +ATTTTCTGCCAAATACCTATAATATCGCTTCGAGACCCAACTATTGCACA +GTTGTGGTTTATTTCGGTTGAAGACCCAATATTAATTTACCTACAGCTGC +TAAAGCGTTTTAAGACCTAAAAAATTAAGCAAGGCCCAAAAATCCAAACT +TAATACTATAGTACTTCTCGTTTCGAGACCCAAAATCCAAAGCTAGGCCA +TATTCTTGGTGAGACCCACCTGTAATAAATATCACTTGAGTGAAAGTGAA +CTCTTACTTTTTTCTTTCGACAGCCAAAAAAAATTGAGTCAATTAGCAAA +TAATTCACGTCTCCCCCTTTCAATGTTTACATACACATTACGAACGAGAA +AAAAAAACGAGAGAAAAATTGAGTGAAATGGAATCAAAATGTGTTCATTT +TTACTTTTTATGAAAATTTGGATAAGCACATGGCGTCAGAGTGTCCCATT +TCGGCTTGATCTACGTAGATCTACAAAAAATGCGGGTGAAGAGACGCAGA +GTTTTCAACTGATTTCGCTTTTTTTTGGGCGAAAATTTCCGCATTTCTTG +TAGATCAAACCGCAACAGTGGATAAGCGCGCTCTATCGACAAACCCGGTG +TGTACTACTCGCGGACAACCAGTATAGTTTTTTTTTTGAATTTTTGTTCG +AAATTGAAATTGAAATAAGATGCCAAATTTAAATTTAAAAAATAACAATT +TTTGAAATTAAATTTTTAAAAAAATTCCCCGTAAATCTACACTTAGTCGC +GTAAATCGACAAGGCTATTTTTTTCAATTTTTGCCCATCGCACTTTTTTT +GCCCAATCAATCATCGTCAATTGATCCATTGATCTTCTTCTTCTTCTCTT +TCTCTTTTCTCACCACCGAAAATTTCATTTTATTTTTTGACACTGTCTGC +GTCTCTCTGTACCCCCTATCTCTCGCCTCTCAAGGACTATTACAACGAAA +AATTTGGGGAGAAGCCGTGATTTTCATTTTAATTTTGATGAAAAATTTTA +ATGAAAATGAAAAAAAAAATTGTTTTTCAAAAAACAATCCCCTCGTAAAT +CCACACCAAATTCAATATTCACCTTATTACAAATTGATTATTTTTCCCAA +AAAACACACGACATCGGGCGCCCATCTATTGTTTTTTATTCCAAAAAATT +TCTGCAACTGTCTGGGTCTCCGGTTAACACTGAGAAACAACAAATTTCAT +TTTTCGATTCATTACATTCATTTTGAAGGTTTTTGGTTACAAATTCGACA +CGGATTTCTGGCTTCCCTCATAAATTGAAATGGAAGAGTTTGCTGAACTA +GGCCAACTTGGCTCGGCCATATTTGGCATAGATTTACGGCGCGTTGCGTG +CCGCGTCGCGCCTCGATTTTAGTTGTAAAACTAAATGTGAAGTGTCCGTG +TGGAGTACACGACTTTCCCACGCGTTGCCCGGTGAGAGATTATCAATGGA +GCGCGAAAAATTCAATGAGGTAGGTCAGAACCCCTTGAAAATTGAGAAAA +AAAAATCTCACAACGATACTCCGCAAAGTGTGCGTGTTGTTTATTAAATG +ATAAATTCAAAAGCAAATAGCGATTTTGTTTCAAAAATATGCCGAAAAAA +AAGAAAAAAAATTAAAACAAAAGTTCAGCCACCAATTTTATTTCTCGGCC +ATGGTTGTGTCGTTGTTTATTTTTTTGCGATCGTATTTTTTCTATAATAA +GACTTAAAATGAAAAAACATTAATAAAAATCAGTTTTCCATGGCCACTGT +CAAAAGTCGCAACGACACTCCCCTTCCAGGCTCCTCCCCCCCGCGTGTAT +TTTAGCATGTAGTGTAAATTACGCGATTTTGTGTATAAAACCCTAATTTT +TTAGAAGATTTGAGAAAAAAAACTTTTAAAAAATGGGAAAAAATCCCCTT +TCCCTTTTTTGAAATACTTTCCGACAAAGTTTAGCCAAAAGTCCAAAAAA +AACCAATATGGCCTAGAAAAAATCAAAAACTCGGCCATCCAAAAAACTAG +GCTACACGTTCTTTCGACCTCTGCTCCCCACACCTATGCTGCCCATATCA +AATGTCTCCCGGACCCCTCATTCCGTCACACATTTCTCAAAAAAATGTCT +CTTTTTCTCAAATTCTCTGTCGAAAATCCCATATCTCTTCAGTGTTCAGA +ACTGACTGTTTTATTTCAATTCTCATGATCTCATGTCTCCCGTATGACTC +ATTCCTTCGATATATTTTTCTTTTTTCAAAAATCATTTTTCCTATATATA +GACTTTGTTCGGTGGGAATTTCTCATTTCAAAATATTTATTGAGGTCGCT +TGTTCCCTTTTTATATGGTCGTGGCCTAGGTTTCTAAAACTCGGCTACCA +TTTCCAAGTTGTAGCTTCGAGCTCTTTGTCTCGGAGTAGAAAAAATTCAC +GAAATAAATAAAAGTTCACGTGGCCGTGGCCTAGATTTCCAAAACTCGGC +CACCAATTTTTTTTCTCTTATCAGTAAACCACGTAGAACTCCTTTTTTTC +TAGCCATTTTTTAACTGAATTTCCAACATATTCGGTGGCTCCATCAATTT +TACTGATAGTAATTTCCAATAAAAAAAGGTATTTCTGTCGATAGGAACCC +ATTTTCATCTACTTTTTGTTTCTACTTTATGGGTTTTGCCACTTTCCCGC +ATGCCTACGTGCCTACCTATCTGCCGACCTAATATACCTCGTAGGCAGAC +CTCGGCCGCCTTGTGGTGAGATGCCAGTCGCTTTGTAGGCAGGCGTAGTT +TGTCTTGCTGGTATGAGTAGGCCTGTCAGCCGCCCAGTAGGCAAGCGTAG +GCATGATGCAGGCGTAGCAGGCTTCTTAACTAGGCATCGGCTGCCTTGTA +AGCCGGCGCAGGTAAGTGAAGGTTTCTTCGTGGCTGGCATCCTTGCAGTC +AGGCACAAGTCGTCGGCTTGAAGGCAGGCAGATGCCGCCTAGTAGGCAGG +CATATTTTACTTATAGGCAGGTATTAATGATCCTCTAGGCTTGCGTTGGT +CGGTTTGTAAGCTGTCGTAGGCTGCCTTGTAGGCAAATTGAACTCTCAAA +CCAAACAACACAAAAATTCCAATATTTTTTGTACCTTCTGATTTTGATCT +CTGACTCATGATCTCTTTATCAATCTCATATCTTCCATTTTTAGAAATAA +ACAATTTTTCCCTTCTATTCATTGACTTTAATCCCTTTCAATATTCATTC +AATACACCTATAATACGAAAAACTCTTATCTTTTTTCATTTTATCACACA +TGGTGCATAATATTATAGTTAGTGGCTATTGAAAAAGCACATCATTTTAT +CACTTTTTGTCACTTTTCCACGATTCTCAACGTCTTTTTTTTAAACACAA +AACGTTTCCCGTCATTTTCTACAGTACTCCCGCATTTTCATTTTCCAGGT +GAGACCTGAGATGGAGGGCGACGAGTTGGTTCATCGTCCGACGGTCCTCT +CGACGACGGCTTCTGCCACGTCACGGCCGCGACACAAGACTTTTGAGCTG +TTGGGTCCGGTGAATAATATCTCGTTGGCTGATATGTATAAAGTGTGCGG +GAAGATAATTGGCAGGTTCCCGATTGCATTTATTATTGCGACGGTGATCA +TGTGCAGTGGTGGATGTTAGTTTTTTTTGACGTAAAAAATACAGTTTGAG +AAAATCTTTTTTTAGATCAAAAAAGAAGAAAAATATGGAAAAAACAACAT +TAAAATATTTTTTAGAAATCAAAAAATGTAAAAACTGTATGATTTTACTT +AGGGCCTCCATGGTAGACAGGCACGGTTTTAGGGCCTGACGCCTGCCTGA +AACCCACGTGGAGTCAGAAAGTCCCATTTCGCTTTGATCTTCAAAAAATG +CGGGAGAAGAGACGCAGATATCTCATCTATTTCGCATGGTTAAGAGCGTG +CTGACGTCACAATTTTTCTGGAAAAATAATCCCGCATTTTTCGTAGATCA +AACCGCAATGAGACAGCCTGACACTATTAAGCCGCAAAGGCAAAAGTGTT +TGCCGTCTGAATTTTGAAACAAAAGGTTTAACCGGTGAAAATTGAAAAAA +AGTATAATAATAATAATAATAAAAGTAGAACTATTTTCAGTATACTAAGG +CAAAATGATTGTTTTATAAAAAAACTTAATTTTAAAATTAGATCTCCTAA +ATGTTTCAAGCAGCACAACTTTCATGTGATGTCAGGCTGTCTCATTACAG +TTTGATCTACAGAAAACGCGGGAATTTTTCTCCCAGGAAAATGTGACGTC +AGCACACAATGCATAATCAGATGAGATTTCAGCGCCTCAACTCCCGCATT +TTTTGTAGATCAAACTAAAACAAGACTCTCTGACACCACGTGAATTTTCC +AACCATCAAACTATCACAAAAAAATTGGCGCCAAAAAAACTTCTTTAAAA +ACTTCTCATTTCCAGTAGGAACAATCGGTCTCGAACTGAAGGATAATGTG +CGCGACGGGTACACGCCGAAAAACTCGCTATCCCGACTGGAAAATCGCCT +TTATCGAGAGTTCCTGAGTTCCGAAGGTGATCCGGTGATGACTACAGTTC +TCATGACTGCCAAAGACGGAGGATCCATGCATCGGATCAAGTATTTGGAA +GAAGCACAGAGGGTGAGTGGCATAACATATCGGATACCGTATTTCCTCTA +TTAGTAAGGCATGCAAAACTGATTTTCGGACACCTAATTTGATGCAAAAC +TAATAGAGGGTGCAAAACTAATTTTCGAACAGGTTTTTTCTCATTAAGTT +ATATTATAATATCATCAATTTCAATAACAACTTCTGAACCAAAATGGGCG +AATTTTACGACTGATACGCAAAAATTGTCCGAGTTGTACTCATATTTTGC +CAGTTTTGACTTGTTATACCAAGTCTGTAAGAGTTTTCCTAATTTTCAGA +ACGATTTTATAATGCAAATTTTGAATTCCTAAACATAGGGAACAAATTAA +GGGGTGCAAAACTATTAGAGGTGCAAAACTAATAGAGAGTGGAAAACTAA +TTTTCGATTAGTGATTTTTGATGCAAAACTAATGGAGGTGCAAAACTAAT +AGAGGTGCCTAACTAATAGAGGAAATACGGTATATTTTTTTGAATAAAAA +ATTTCAGCAATGGCTCTACATCTCCAAAAACCTATCCGCAGACGTTGGAA +ACGGCGAGTTCATGAAATTCGGAGATTTCTGTGGCCACTACTGCCAAGCC +AACGACATCATAGGATACTTCCTGGACGCCTACAAAACCAAGTCAGCTGA +CCCAAAAATGGATGGCTACCAACTCAATTACCCAATTACCACAGTAATGG +GTTATCAGCTTCATCTCGAGCGTAACTTTTTCGGGGTTACTGTGAATCAG +TCGGATCCGGTCACTAATATTCAGAGTATGAAGGTTCTGACGCTTCCTGT +GTTGTCAGAGGTACGGACGTTTGAGGATACGGATAAGCTGAACAAGTGGG +AGCTGGCGGTTTATAACTATGCTACAGGATACTCTGCACTCGAGGGTGAC +GATCATTTGGTGGAGATTAATGTGAGTGAATAAATTGGACCATTTCAAAA +ATATTGGGCCAGCCCTAAAAAGACAGCGGGCCGGCCCATATCGACCCACT +TAACAGGCTCAAAAAAGTTTAGTTCAGTTGTGTGCCGCAAATTTTGAAAT +TTGCCGAGCTCGGCAAAATCGGCAAATTTGGTAAATCGCATAATTTTCGA +GCTCGGCAAATTCGACAAGGCTAAATGTTTGAATTTTGCCGTTTTCGGCA +AACGGCAAATTTGGCAAATTTGCCTTACACCCCTGGTTTAGGGGTTTCGT +GTTTAATTTTCAAAGCTTAGATAAACCTCTTTTCCAGGTGATCGGTGCTG +AAGTCGTCGACACCGAAATGAACAAGGACGCTCAGAAAATGGTGCCCTAC +TTCATCGTCGGAATCGTCTCGATGATCATCTTTATCTTCTGCACCGTATC +CATCTCTGCCTCCTACTACGGATACTTCTCCTGGCGAATCGGACTCATCG +CCCTCGCCTGCCTCTTGGTTCCGATTCTCGCAATTCTCACTGCATTCGGA +ATCAATAATATGCTGGGAAATCGAACGAACTCTCCGATGATGATCATGCC +GTTCTTGATCAATGGAATCGGAGTCAACGATGCGTTTTTGACACTTCAGA +ATTGGTTGCAGCATAGCCCGGATCTTCCGTCAGGGAAGCGGTTGGGGTAT +ATGTTGGCTGAAGCTGGTCCATCGATCACTACGACCACTTTGACAAATGT +CATTGTTTTTTTGATCGGGTGGATGAACCCAACGGAAGGTAAGGTTCAGT +GGTGGACGGCAAACTACTTTTTCCGGCAAATCGGTAAATCGGTAAATTGC +CGGAATTGAAATTTCTGGCAAATCGGAAAACCGGCAATTTGTCGATTTGC +CGAATTTGCCGGAAAAAAAATTGCCGAACGGCAACTGCGCCCTGGTAAGG +TGCATAGCTTTGGCCTCTAACATAAAAAAATTTGTCTATTCATCCTTTAT +TCCAAAACGACATGTATTCCAGAGATGTCAATCTTCTGCCTTGGATGTGC +AATCTCCCTACTCCTCGCCTACGTCTACACCCTCACGTTCTTCTGTCCGG +TGCTAGTTCTTCTGCTTAGCGAACGCGTCAATGAGCCCAGCAAGCTCGAG +GGCACTTTCAACAAGGTTCTCGGATTCTACGCAAAAATCATATGCAGCCG +ATGGACATTTGCACTTCTCATCATCGGAAGTCTTGTCTACTGGGGTTTCG +GTATCTATGGAACACTGGGGATCCGTGCCGTGTTGAACACTGCAAAGATC +CTTCCCCTGGAGACGCCGATCCGCAAACCGAACAGGATTATCGAGGAGAC +CGTGTGGAAAGAGTTCTACCCAGTCACCGTGATTGTGAACAGCCCAGTTG +ATATAAGCAATGCAAATGCACTTCGAGCATTTGACAACCTCGTTCACGAC +TTTGAATCGATGGAAAAGTGCCGGGGATCCGAGTACACCATATCTCCAAT +CAGAGACTATCAGACCTATTTTTACGGTGTAGGAGCCGAGGACTTTGATT +ATGAGGAAGAAACCGTGAAGAACACCTCACATTCTTTAGATTTCAGTGTA +AGTTAGCAGTCCACGCGTTCCTATTAAAATCTACATATATGCCTATAACG +TGTTTATCCACAGAAGAGAAAAATCGCCATATCTGCCGCGCAAATGAATC +CGCGGGAAGAGACAAAACTACTGTAGTTTTTAACCAATTTGTGTAGATTT +ACGAGCTATTGCGTCATCGTTGTATTTAATTTTGAGCCGCAATTTTTAAT +TTTCAGGCGTTTCACACGTTTTTATATTGAAATTTATCTATTTATTGAAT +AAATCTTAAAAGAAAACACAAAAAAATTAGAAAAATTCCGAAAAACGCCT +GAAAATTAAAAATTGCGGCTCAAAATTAAATTCAACGATGACGCAACAGC +TCGTAAATCTACACAAATTGGTTAAAAACTACAGTAGTTTTGTCTCTTCC +CGCGGTTTCATTTGCGCGGCAGATATGGCGATTTTTCTCATCTCTGGATA +AACACGTAATACCTACATATTTTGTGTGCCTAAAAACATGCCTAGCAGTG +AAAGTAGACAAATGTAAGCACACAAACGTGAGTAGGGCTTAAATGGTATG +CAGGCACTGTTTTAGGGCCTGACGCCTGTCCAGGCCTGTCTTGTACGTTT +CATCAATTCAAGCCGTATATTTCCAGAAGCTCACCGGATTCCTTGCCAAC +CCTATCTACAAGCATCACAAGGGAGGACTAAAACTTAACTTTTCAAATCC +GTTAGTTCCTATCTGCCACCTTACCCTAAATCGAGTACCATTTTCAGTGT +TCCAATCCGAAAAGTGCAACTGATATTCGCTTATGAAAACGTAACCTCGT +GGGATGAACGGATTCAGATTATGCAGGACTGGCGGACCATCGCAAGTTCC +CACGTGGCCCTAAATGTTTCAGTGTGGAATGTGAACGCAATGTTCGTAGA +TCAAATGCTGAGCCTGAAGGGATTGGCGATCTCGGTAAGATCTCAATGGT +TCCAGCGCCCTATAAATACCGCTTATTCTTTCAGAATGCCCTAGTCACCT +TGGGATGTATGGCTGCCGTCTGTGTAGTCTTCATCCGCAACCCCCTCTCA +GTTGGCCTAGCGACCGCTTCGATTTTATCCATCTCCATTGGAGTAACTGG +ATACCTGTGCTTCTGGGACTTGGATCTGGACCCTGTGACCCTGTGCGCAG +TAATTGTTTCAATTGGAATGTCCGTTGACTTTGTTGCCCATGTGGCCTGT +CACTATCAGGTCAGGTATAAAGAGTTCGAGGAGAAAGGAGTATTGAAGAG +GATTGAGATGAAAACTCCCGAATCTCGAGTCGTCAACTCGCTGTCCAATG +TGCTCTGGCCAATGGTCCAGTCGGCTTCTTCAACTCTTCTATGTGTACTT +CCACTTGGTATTCTACAGGTACCTACCAATACCTATACTTTACCGATAAC +CCTACCCCTCAAACATTCCAGAACTACCTCCCAATGGTTTTCGTGAAAAC +CATCCTGCTCGTCGTGATCTGGGGAATGTTCCACGGTCTTGTGCTGCTCC +CGTGCATTCTTGCACAGTTTCCCCTGTCTGTGTTCAACAAGACGTTCGCC +GACTTGTTGTTCGGCAGAACATCCTCTTCGTCTTGCTCTTCGGAGTCCGA +TTCGGAAACCGACACCGGTGATGCTCAGGAGATGGTTCCGCTCGCTGGAA +CCGAGAAGGCTTAAGATCTGAAATTAGTTGTTGTTTGTTATTATGTACAG +TTGGGATACAAAGTGTATTATGTAGTCTGTAGTGTCGCAGTGCTACAAAC +TACAAATTCAAAGCTACAAACTATAAACTCATTGAGATCTGGCAGAGCTT +TATAGTTTGTAGTTTTATGTAGCAGCTACAAACTACAAATTTCGATTGTT +GTAGTTTGTAGTATGGCGCACAAACTACAATGTACATTTTGCAAGTTTTC +TAGATTTTTTTCTCACTCACACACACACACACACACCGTTTTGCTACGTG +GCTGCGAAAATGGAAAACTCGGCCACGTCGCAATTCACACATCGCCAGAA +ACTTCTAGCTTTACCAGTAGCTTTTCATGATCTACTCTTCTTTTTTTTCC +CCCCTCAATTTCTATTTGAAATTTCAGAATTCCCTCAATTAGTCTTCTGT +CACCGTGTCCTCCTCTTTTCCGCAAGCGGGTCCCCTTTTCCCCCCACAGA +TCGGCTTCTCAGGGTTCCTATAGCACTTTTTTCTTCGATTCTTGTCACAC +AAAAAATTGTACTTCCATCGCTCGACGTGTCCATTTTTTCTTGTATTTTT +TAAATGCATTTTTTGATAAATTTGATTTTTTTTATCATCCAGAAAATGGT +CAAAAATTCAGATTTTCTTGCTGGGATTTTGCTGGAATTTTTTCAAGCAT +CAGACATGCAAAAACTTATGCAAAACTACACAACACTATCGATGGGGACT +GTTCGACTCTTCACCCCAGTCAAACTTTTTTTCACTATTTTTTTTAACTT +CTGTTTTTTTGGTACTTTTCTGGCCGTTTTTATGGAATTTTTTAACCCGA +CATTGGAGTTTACCTTTTTTTGTTCAGGATTTTAGGAATTTCTGCGACCT +TCTCACTCATGTCCTCCAGCCCCGCCTAAGCCTATGCCTTAACTCAAGCC +TAAGCCTAAGCCTAAGCCTAACCTAAATCGCGTCAGAGATAACGTTCGCC +ACTGACGCCAAGCCTCAACCTAAGCCTAAGCCTAAGCCTAACACTAAGCC +TAAGTATAAGCCTAAATCTAGGCCTCAGCCTAATACTAAGCCTAAGCCTA +AGCCTAAACCCAAGCCATAAGAAGACACTCTAAAAATGTTCAGATTATTA +AAAAATTACATTCAAAGTTTTCTTCAAAATTTTGCTTTCGACTTTCCAAG +TAATCAATACCATGTAGAATTCCAAAATCTTCATACAAATCCCTCCCCTC +TTCACATCTTTCCCGACAGCTTGTACTATTTCTCCTCCACCCACTAGGCC +AGGTCAACGCTGCGTCTCTCGTGTTTCATATGCTATCTCCCTTTTGTGGA +ATCCGTTCATCGTTTCGGATCGCTTACTTCTTCCGCGCGCGTCGCATTTC +ACTTTGAAATAAACTTCAGTTTTCCTTTCCAAAATTTAATTGGTGGAAGC +GTTTGAACATGCGAAATTTGTTAATTATCGTGTGTATTCATTTAATATTA +CTACTTGTACATTTTACCGATGCATGTAAGTTTTGGATGTATCAAAAAAT +TAAATAAATTTCTTAAAGGTGGAGTAGCGCTAGTGGGGAAATTGCTTTAA +AACATGCCTATAGTACCACAATGACCGAATATCATGATAAAAAAATTCAA +AAAATTTTTTAAAATTTTATATGATTTTTTGAAAATTGGAAAAATCTCAG +TTTTTGCCTAATTCCAATTTGAATTACCGCTAATTGGATTTGTTCGATGG +AGCGCGCTTGCACGTTTTTAAATTTATTTATTTTATTTTTTGTTATTTTC +CACCGATTTTTAATGTTTTCGGTGTATTTTTGCTCTAATTTTAGAGAAAA +AGTCAAGATGAATGCAGATTTTCGATTAAAAAGCACGCTCACAGGCGTAA +AAATGACAAAGTAACGATTTTAAACGGTTTCGAACCTGAATTAATTAATT +TCACTGATTTACGACTGTAAGCGTGCTTTTTAATCGAAAATTTGCATTCA +TCTTGACTTTTTCTCTAAAATTCGAGCAAAAATACACCGAAAACATTAAA +AATTGGTGGAAAATAACAAAAAATAAAATAAATAAATTTAAAAACGTGCA +AGCGCGCTCCATCGAACAAATCCAATTAGCGGTAATTCAAATTGGAATTA +GGCAAAAACTGAGATTTTTCCATTTTTCAAAAAATCATATAAAATTTAGA +ATTTTTTAAAGAATTTTTTTATCATGATATTCGGTCATTGTGGTACTATA +GGCATGTTTTAAAGCAATTTCCCCACTGGCGCTACTCCTCCTTTAAAGTT +TGAAGTTTTAGTAAAAAAAGAGTGTCGGTTTTTTAGTTAATAATATTAAT +TTCCAGTCGCCGGAACAGTTCGACCATTTTTCACCACTCTTCCAGTACCT +GGAAGAAATGTTCCTATTATGAGATTATTCGAGAACTATGCTGCATCGTG +CCGACCAAAAAGTAAAAAGGACTTCAATGTTGATCAGCTGGCAAATGTAG +GTTTTTTCCCGCAAAAAGTCGTATTTCGTGCAAAACCGGCAAAAGCAAAA +ATTTTGAATACCGGCAATTGTCGGAGTTGCCGATTGCCGGAAATCAAAAT +TGCGGGAAATAAAATTTTGATACTTTTTTGTAGATTTAGGAGCCTAAAAA +TGCATTTTAATGAACAATTTTTAATTTTCAAGCTCAAAATGATTTAATCC +TTTAAGGATTGACCGTTTTCTTTAAAAAAGACTAACCGAATACTATAAAA +AAAGGTGAAATTTTTTCAATTTCCAAAATATAATTAATTTTGGCAACTGC +CGATTGCCGGAAATTGCCGATTGCCGGAACTTCACAATACCGGCAATTGC +CGAAATTGCCGATTGCCGGAAATTTCCAAAACCGGTAATTGCCGGAATTG +CCGATCGCCGGAAATTCCCGATTGCCGCGCACCCTTGTATTAAAGGATAC +GGCAAACGATTTTTTCCGGCAAGCGGCAATATCGGCAATTGCCGAAATAA +AATATTTTCGGCAAACGGCAAACGGCAGTCAGCAACATGCCACTTCTCCA +ATTTTCGGCAATTTCGGCAAACGGTCAATTTGCCAGAAATCATCGGAAAA +TTGTGATCTTGCACATTTTTTCTGGAAATTTCAGAATTTCAATTTTAAAC +AACAACATTGTACACATCCTATGAATGACACATATCTTAAAAAGCCAGTA +AATTCTATAAAAAATATCTAGAGAAACTGGCAAAATAATTAAAAAAGGCA +CGGATTCATGTGATTTTGATTATTGAAAATATCTTTGAAAACTTTCGGAA +AATTGATATCCGGCAAATCGGCAAATCGGCAACTTGCCGATTTCCCGAAT +TTGCCGAGCAATGAACTACACTGTTCCAAATCGAATTCGTAACCGATATT +ATACTTAGGAATGATATTTGTAACTCGTATAAATATTAAATAATATATAT +ATATTCCAGCTTCTCCAATCTCTCCAAATGGATGAAGTAGCCACAAAAGC +CTACAACTCCCTATTCTTCTCAATGGCTGATATGCAAATCGAAAAGTTCA +TGGGTAAATGGTACACAGTTGTTGATTCGAAAGAAGTTCATAAAGAGGAT +TGTTCAATTTTCTATTGTAAGTTTATTTTCATTCTGAAAATGAGATGCAA +ATTTTCAGTCGATATGGTACTTCAAACTCCATACACCGCAACATTCACCT +CAAAGCAGTACGGAGTGATTAATAATGATGTCGTCACCAATGAGGGGTAC +GGTAGTATGGTTGGTCCAGAGCCCGGAGCCGTTCTTATTACAACTGGTAG +TGAAAGGGATCAGTGTCCATGTAAGTATTTTAAATAACTTTGGTCCGGTG +ATATTAAGATACAAGTTTAAATACTTCCCGTTTCAAAAACTTCGAATTTC +CCGCCAAAACTTTTCTCTGAAAATTTTAATTTCTTTCCAAATTTTTTTCT +TTGAAAATTTGAACTTCCCGCCAAAATTTTGTAGTCAAAAAATTTGAATT +TCTCTCCAAGAATGTTTTCTCAGAAAATTTGAATTTCCCGCCAAATTGTT +AATGTCAGAAATTTTGAATTTCTCGCCAAAATTTATTTTCTGAAAATTTG +GATTTCCCGCCAAAATTTTTTTCTCAATAAATTTAAATTTCCCGCCAAAA +TTTTTCTCTGAAAATTTTAATTTCTTTCCAAATTTTTTTCTTTGAAAATT +TGAATTTCCCGCTAAAATTTTATTGTCAAAAAATTTGAATTTCTCTCCAA +GACTGTTTTCTCAGAAAATTTGAATTTCCCGCCAAATTGTTAATGTCAGA +AAATTTTAATTTCTCGCCAAAATTTATTTTCTGAAAATTTGGATTTCCCG +CCAAAATTTTTTTCTCAATAAATTTAAATTTCCCGCCAAAATTTTGTTAT +CAAAAAATTTGGATTTCTCGCCAAAATTTTATTGTCAGAAAACTTGAATT +TCTCGCCAAAGTTTTTTCTCAAAAAATTTGAATTTCCTGTCAAAACTTTG +TAATCAAAAAATTTGAATTTCCCGCCAATTTTTTTTCTCCGAAAATTTAA +ATTTCCCGCCAAAACTTTGTTATCAAAAATTTGAATTTCTCGCCGAAATT +TTATTGTCAGAAAATTTGAATTTCCCGAAATCTCTATGAATAAAACATTT +GCAGTTTTCCCTGTACGAATCGGTGGCTTGAGTGACGAAGGAGAATATCA +ATACATGATCTTAAGTACACCACTGAAGTATCCAACGATGGTCTTGACAA +GGTAAGTTTGCCTTAAAATTTGTTTTCTAATTATTCCAATCTAATATTCA +TGTGATGTTGAAAAATGCAAACATGTATTTTAATACATTTTCCCCCTATT +GATGCGTACCGAAAAATGTAGAAAAATGGAATCATTTTTTTGCATTTTTC +GACATTTTCGACATTTTTGACATTTTCCGACATTTTTCGACGTTATTCGA +CATTTTCACGCATTTTTCAGAGTTTGCCGAACTAGGCCATTTTGGCTCGG +CCATATCTGGGGTAGATTTACGGCGCGTTGCGTGTCGCGTCGCGGCTTGA +TTTTAGTTGTAAAACTAAATGTATTTGTCCGTGTGGAGTACACGACTTTC +CCAGGCAATTGTCAATGGAGCGCGAAAAATTCAATGAGGAAGGACAGAAC +CCCGTGTCCACAGGAAGAATTTTCTCTGCGTCTCTTGTCTTTAGCATTTA +AAGTGGGGCGACGCCGATGTAGAAAAATGCTGAAAAATTTCGAAAAATGT +CGAAAAATGCACAAAATGATGGCATTTTTCTACATTTTTCTGCATTTTTC +GGCACGCAAAAAACATCACATGAATAACCCCATAAAAACTCCAATTTTTC +CAGAGACCTAACCCTATTCGAAACGAAATGGAAGCGAGAAGTGTATGATT +TTGTTGAGAAGAATGGTTTCATGAGTCCAATGGCAGCATTGAACACTCGT +CTCCATTTCACAGATGTCGATGTTTGCAGAAAAGTGAATAAGTTATATGA +GAATGGAAATGTTTGAGTTGAAGATTATCTTTTTTCTGATGATACGGCAG +AGTTTTTGACGGGTTGTGCAGTGTTTATTTTTAACCTTCATGTGTATTTA +AAAATAAAGATTAATTTAATTGAATCTGTGTTTAATATGAACTTTTAAAA +CACAAAATTTCAGATTTTGGTTTAAAAACTGTAGACACTTGATACTTTGT +TGAGTGTACCTAATTTGAATTTCGCGAAAAAATGACTGTCATATGATTCT +TGACCGTGTACACCTCTCGGGCAATACATTAATATTTTAATATTATGGAT +TATAAGCATTTTCAGTAGACTTTCCATATTTTCTCATGATTATTACTCAT +TTTTATGACGAAAAGCATTGTTTGGAACTCAAAATTATCAACTTTAAATG +TTAAAAAATATTCAGGAAAACATAATATTTGCCTATTAAAAAATTTCCCA +TTAATTTTCCACAAAAAAGTTTCTTTTTTCTTTTTTTAATTTTTTCTCAG +AAAAATCAAATCTCCCAACAAAGTTTTTCTCAGAAATTTTGAATCCACCG +CCAAAAATTTTTCTCAAAAAATTTGAATTTCCCACCAAAAAAATTTTTCT +CACAACTTGAAAATTTGAATTTCCCACCAAAAATGTTGTCTCAAAAATAG +TAAGTTTCCCGCCAAAACTTTTTTTAAAAGAAAATTTGAATTTACCGCCA +AAAATTACTTACCAGAAAATTTCAATTTCCCGCCAAAAATGTTTTCTCAG +AAATTTTTAATTTTTGGTCAAAATTAAAATACTACTACGGTACCTTAATC +CTACACCTCCACCCAAAAAATCATTTTTCAAAAACTACTACAGTACTACT +CCTACAGTACTCCTACCGTACTCCTAAAGTACTCCTACCGTACTCCTACA +GTACTCCGACCGTACTCCTACAGTATCACTACAGTACTCAAACCATATCC +ACCACTAACACCAATCCAATATCCCTTCAAACGACAATAACTTTTTTATT +CAAAAATACAGTAATCTTACTGTAGACAATCTTTTAAATTATAGTCTTCA +TCCAAAACTATAACGGACTCCATCCCATAAAAAGTAAACGACAAGTCATA +AAAATTGGAATTCGCGTAGTTTGCTCTTCCGTGAAGGCAAACACACGTGC +TCAGCTATATTGATAAGAGATGAAAAACGAGAGGAATCAGTCGAGGTGTC +TGATCTACTTCCAGGATGGTGACCGCTCTTCTACTCCTATTGGCTCTTGC +AGCCACCTCTTTGGCGGCTCTTCCAGATTTGGGATATCCCGGATGGCAGT +GCGATGCATCGCTTTATCAGAAGTAGGTGGCTTACTTTAATTACTAAAGT +TTGAAATTTTCCTCGCTTTCAGGAGCAAAAATACCCCGACTTCTGCCCAC +TCCGTCCGATTCACCGACATAAAAGTTTTGGGAGCTCTCGGAGACTCCTT +GACCGCCGCCAATGGAGCCGGAGCACCAAAGGGAGACCCTCTGGCTGTGA +TCCTTCAGTACAGAGGACTAGCCTTCCAGTGTGGAGGTGACCACTCTCTC +GACGAGCATGTCACTGTTGCAAGTAAGCCATTTTTCTGGGGAATTGAGAA +AACTGAGTTGTTGTAGATGTGCTGAAAAAGTTCAGCCCTAACCTAATGGG +ATACTCCACTGGAATCGGAAGTGCCAACGTTTGGGAGGTCTCAAAACTGA +ACCAAGCAGTTCCAGGAGCTGAAGCAATCGATATCATCACTCAGGCCAGA +GCTCTGGTGCAAATTATCCAAAGCCACAAGGAGGTAGCCAAGTCCAAACT +AAACATCAATTCCGATGCATTTCCAGATTGATTACAAAACTGATTGGAAG +CTTATCAACGTATTCATTGGAGCAAACGACATGTGCGCCTATTGCAACGA +CCGAGAAAATGTAAGATAGTCAAAGATCATTCCACACCCGTTTTATTGCA +TTTTTATAGGGCCCACACTCAAAAGCAATCTGGAAGCAAAATGTGATCAC +TGCCATTCAAATTTTAAAGGATAACTTACCAAGGTAGGTAAACTATAGGG +ACATGACATTCTAAAGTAAATAACTATAATATTATGAAATTGTCACATAC +CTATACCTACCTATAAATACCTACATGGTCCAGAGCTGTGTGGCAAATTT +TGAAACCAGCAAATTCGGCAAATTTTCCGGGGTCGTCATACTTGGTAAAT +CGCAACATTTTTTGGAGCTCAAAAAGTGCCAAAATTAACAGAAAATCTAA +GTTGTTAAACATTTGTGGCAAATTCCAAATTTGTCCAAATTTTTGAAATT +TGCCTTGCTCGGGCAAATTCGGCAAATTTGCCGTGGTTGTCGGACTCGGT +AAAGCGCATCATTTTTTGGTGCTCAAAAAGTACCGAGTTGATGGAAAAAC +TAAGTTGTTAAACATTTGTGGCAAATTACAAATTATGTCCAAATTTTTGA +AATTTGCCTTGCTCGGAAACCGGCAAATTCGGGAAATTTGGCACACCCTT +GATCCCATAGCAGTGGCGCAAAAAAATCTTTAAAATTGTGGCCGTTTCCG +TGCCAATTATAAATTAAAGTTAAACATATTATCGAAAAAATACGATCGCA +AATTTTTCTCGTAACTTATTTTTGATCTACCTTGTTGACTAGGCTCCTCC +CCTTCCTTCGACAAGACAGCCACAACAAAATAACAACGGCAACAAGATTA +TGGGCAAACACGTGGTGCCAGGCTGTCCCATTACAGTTTGATCTACAATA +AATGCGGGAATTTTTCGCCCAAAAAAAAAGTGACGTCGGCACGTTCTTAA +CCATACAAAATCAGTTGAGAACTCTGCGTCTCTTCTCCCGCATTTTTTGT +AGATCAACGTAATTCAAGCCAAAATGAGACACTCTGACACCACGTGGGCA +GAGTCAACTTCCAAAGGTAGATCAAAAATTAATTATGAAAAAAATTTGCG +ATCGTATTTTTCGATAATAAGAGCCAACATTTTTCGGCTTTTTATGGAAA +TTTTTTTTTCAAAAAGAGGAGTATGGTCCATAACTATGCCATCAATACCA +AGTCCTTCCAGAACCATCGTATCCATGACCGGAATGTTCGACATGGCCAT +GCTTCGCCAAATCGACCACGACAAGTATTTCTGCGACGGCCTCCATGTGT +TCGAGTGCCCATGCGAGAAGAACAAGGACTTCCCGAATACCGACATCTCG +GCTGCCTGCCATCTTTACATGGATGCTCAGCAGGAGATTCAAGACTCGGG +AATCTTCGACTCAACAGATGACTTTACATTTGTCGTTCAACCATTCTTCA +ATGGAATCACAGTTCCACCACTCAAGCCCGACGGAGAAGTCAATCTGGAT +TGGTTTGCACCGGATTGCTTCCATTTCTCAAAACTAGGCCACGCCAATGT +TGCCAAGCACTTGTGGAACAATATCGTTCAACCAGTCGGATCCAAGAACC +ATCAAGTCAATCTGTCAGATCCTACCATTCCACTAAACTGCCCAGACACC +AAGTGCCCATTCTTCAGAACAACTAAGAACAGTGTTGACTGCTCGAAATA +TATGACTGCCTAGACTGTAGGAAATTGTGTTTGTGTGTGTAATTTGACGT +ACTTATCGGGTCTGCAATAAAATGTTTTATCGTGTAATCTTTAATTTTTA +ACGTGTGAGACATAAAAGAAAGAGCACCCTCAATAAAAATATCCACGTGG +AGTACACAATATAGCTATCAATAGAGCGAGTAAATATTTTTGCAATAATT +ATTTATTAGAAGAATGGAGATCAAGGTAAAGGAAGAGATCTTGATTTTGA +AAAAAAGATACTGGAAATACTAATTGTTCACGGGATTTCATAGAAGGGGA +TATATCACGACTTTTTCTTTGAAAAATAAAAACAACATAAAATTATTGCG +GCTTCACAATCTGATCATCCGGTATTTCTCCAGATCTTTCCTTTTCCGAT +TCGATCTTCTTCCACTTGGTACGCCGGTTTTGGAACCAGATTTTCACCTG +GAATTTGAGAAATTTCAGCTATGCGTTGAGTGCCGCGTTACGTGCTGCGT +TGCGTGCTGCGTTGCGTGCCGCGTTGCGTGCCGCGTTGCGTGCTGCGTTG +CGGGCTGCGTTGCGTGCCGCGTTGCGTGCCGCGCTGCGTGCCTACCTGCG +TCTCCGTGACATCCAATCGTTTTGCAAGCTCACTTCTGTCACTACTTGAC +AAATACTTTTTCGCCTCAAACTGCTTCTCCAGTTCGAATACTTGTTTCCC +GGAAAATGTCGTCCGCGCCTTCTTTCTCTTTGTTTTTTGACATTTTTCTA +TAGGAGACTCTTTGGCTTGGTCGAGGCTGGATTCTGAAAAAATATTCTTA +ACGGCTGATTATTTTTCTACGTGTAGCATTTTTCCGAAATTCATTGAACA +AAATTAGTAAATTTCCAAAAAATTTTTTTTCCAAAATTTCGAAAACATTT +TAATTTTTTTCAGATTTTCTAATATTTTAAAACAAAAATTGAGAGTAAAG +GAAATAAAAATTGTGTCTTGTAATTTTTGTAATTTTTACTCAAAAAAAGG +CCAGTGAAATACTATTACAGAAAATACGAATCGATGCACCATGTCAAAAA +GAATAGTATTTCACCTCAAATGCACCATGCCCAAAACTAGTCTATTTTTC +AACTACAAAACTTCATACACCTAATCCAAAGAAATCAACTTACTGCATCT +TCCAAATTCATCAATTTCTCCATTAACAGTTGGTAAGTCAAGTATATCCT +TTATCAGGTGACTAGTTCTTCTCTGAGGCTTCACATCAGACGTCAACAGT +GCAAAATAGGGTTGAAGTAGTTGGAAGAGCAAGTCAGTTTCCATTTTGCA +CGAATGAAAAGAACTTCTGAGAGACTTCTCTATACAGTAGGTCTCGAGGT +CCCCGCCTTCTCTTCAATCAAATAATTGAAATTCTGGACTCTCGGGGGAC +TTTTGACGGTTGACGACGACGACAATTTGCCAAAGTGGTCGACAATGATT +GCGCAATTGGTGTGGAAAGAAGAAGAAGATGGGTGAGTTCTGAGATGATG +ACAAAAAGAGCATGAGCCAGCAAATTGAATAAGAGACCGGATTTCGAGAA +GGAGGAGGGGGAGAGGAGGATTGGTGGTAAGGGATGATACTTGATGCAAT +TGAGGGAATGAGTTTCTCATACTTGACTATTAAATACTTTTCTTGAACTT +AAATATTTGAATTGAAATTTTGGAGTAGCGGAGGCACATGTGATATTATT +GTGCTAATTTGTAATACTTGGACTTTCAAATATAACCTCAATTATTTGAA +AAAAACCTTTTGAATAGACCAGCAAGGTTGATCTACAATTTTTCATGGAA +ATCGAATTAATTTTGTAAGGATGTCTACTGAGTATAAGCTTATTGTTAGG +CTTAGGCTTAGGTCTAGACTTAAGGCTACACTTAAATTTAGGCCTAGGCT +TAGGCTTAGGCTTAGGCTTAGGCTGAGGCTTAGGCTGAGGCTTAGGCTTA +TGCTCAGACTTAGGCTTAGGCTTACGCTTAGGCTTAGGCTTAGGCTTAGG +TGTTGGCTTCAGAATAAGCTCAGGCGGGGGTGAGGGAAGGGTAGAAAAAA +AAGAAAGAGAAATTTCCAGAAATTCACAAAATCCAGAAAAAAACATATCT +TTCACAAGTTTATATTTTTATAGCCTAAAAAATTACTTTTAAAATGAGGA +TATGCAACCCGCACGCAAAAAAACCTTTTTTTTTTTGAGCAATTTCACGG +CTCTTTTTTTTTTAATTTAAAAATACAATAAAAAAACCAAAAAAATTTTC +CGAGCCCAAATTGCTCCCAAATGCTCTAAATTTCTTTTGAAGTTTGATAT +ATTCCTATTAGAACTTGAGGAAAATGTAAAACTAGAGAAACATAATACTA +CGCATGTTAAATGTAAATTACTTACTTTTAAAAAGTCGTACGTTATTTTG +GAAAGTTTGAGGTTTTTGCATTTTTTCCGTAATATCACTGAACACTTTTA +TTTAAATATCATCAATTATCGGAAGTTTATAGGTTGCAGGAGAAAAAATA +TATTCTAGCGGGAAAATGAAATGAGACGGGGGGACATTTTTAACCAAAAA +AAAATCAGAAAACAGTTGGTAATAAAATTATTCCAAGAAAGTATAAATTC +ATGACTTCCATCTTGGGAACATTCTTAAAAAATGTCAACGAATAAATCTT +TGTGGCAAACAAACTTTTTCCATAAATGTTTCAGACCTTATATAGCGGAC +ATGAAAGTTGATTGCTTATTTGATATGTCTTGAGTTTATTTTTTTTTATT +TCAAGCGAGGGGAGATTTATTTGCCTAGATATATATATAATTATTACTGG +AACGAACTGGAAAAAAACTTGGGATCAAAAAAATCAAAAATTCAAATTCA +AAAATTCAATTTTTCGAAACTTTTTCTACAGCTTTGTCGAGAAGCAACAG +ACAAATACTTATAGCTAAAATTTTATTAATATTCTAGTTTTAGTCATGGT +GAATCGAGAATTTGTCAATTTCCATGTGGTATCTTAAAAATAAACCGATA +CACGTGGTGTCAGGCTGTCTCATTGCGGTTTGATCTACGAAAAATGCGGG +AATATTTTTCCAGAAAAATTGTGACGTCAGCACGCAAAAATTAATAAGGG +TCTAACCAAAAAAACTTGAATCTTGGAAATATTTTTAATTCACCCTAAAT +TTTCCCCTGATTCCGAATATCTATGTGAAAAAATTCAAAAAAAATTTCCT +GAATTTATATTTAAGCTTGAAATCTTTCATAAAAATTTTTTTTTTTTAAA +TTTCATTTGTACTCGCATCACTTTTTTCAAACTCGCGCCCAAATAAATTA +GCGCGCGCGTGCATCGTTTGACTTTTTTTCGTTTAGTTTTTTTTATTTTA +GCCGAATTCAATTTTTTTAAAACCAGTTTCATTCATTTTTGTCGGTTTTT +TTTTTCTGAAAAAAATGTAAAAAAACGAAAAAAAATCAAACAATGCAAGC +GCGCTCCAATGCTAATTTATTTGAGCGCGTATTTAAAAAAGAGACCGGGA +TACAAATGAAATTCGGCGATTTCAAGCTTAAATATAAAATCTGGCAAACT +TGTTTTGAATTTTGAATTTTTTCACATAGATACTCGGAATCAGGGGAAAA +TTAGGATTCATTCAAAAATATTTCCCAGATTTCGGTACCCCACCTTAAAA +ATTTTTTTTTGGGAAAACAAGGAAAATTTCTAGCTTGAACTTATTTTATC +AATACCTAAAATGCTGAACATTAAAACACACACACCCGTATGAGTATTAT +ATACTTCCAAGGAAACATTTGAAAAATAAAGAGTTCTCCGCTTTGATTAT +ACACTTGTGATATTCTCACGCCTGGCACTTGGCACCAGCTCAAAGTGCTC +ATTTTGGCTATAATTGTTTGAAGGTATATGAAAAAGTGGAAATTGGGAGG +AAAAATGGCATGTTTTGGCTTTCTCTACCTGGCCTATGTGTTAGAAAACT +CTTCTATGAAAATTCAGTTTAATTTTTTAATTTTTCTTAATTTTTAAAAT +TCTAAAAATGGCTAAACTTTCAAAAATATAATTTTTAAAAAGCCAAATAC +TATAAAATTTCTTTGTTAATTTCTTTATAACCAAAATTAACGATTTTCAA +AAGTCAAATTTTTCAAAATTACAAAAAATTTAAAATTACTGTAAGATGCG +CAAAAATTACAGAGTTTTCAAAATATAAAACACTCTTGTGGCCGAAAACT +TCCAAAGTTCAGGAAATAAAAATTCCAAAAAAAAATCAAGAAAAAAATGT +ATCTCGAAAAATTACCGCTATTAGAAAATCGCCTTCTCTAAAATTTCCCA +AATTTTGAAATTATGGAAATTCCCAGATTTTTCAAAAGCGATCTAGTCGG +AGTTGTCAGAAAAAAAGTTCAAGAAAACTTTCTCTAGAAACTCAAAAGTT +GGCCTGATCAGAACTTGTTGGATTTTTTCAATTTCCCAAAAAATTTTCAA +AGTTGCCGAAAATTACCGAAACTCCAGGGCTCACTTTTAGACCTTAAAAT +GAAACTTTTGCCATTTGAAAGAGGCTCTTTGAAAAAGGTCTCTGCAAAAA +ATTTAGCGGCAGACGAGCACTTTGAACTAGAAAAATGTCGCTTTGAAATT +GCTATCATTGAAATTTTTCACTACTATAGAGGCCGGTAAAATTGCTCCAA +ATCATAATTTAAAATATTTTTTCATGATTTTTTTTTATTTTTTCATGATT +TTCGAGGTAGGCAAATATTCTGGGAGCTTTTTTGGATATATTTATTTTTT +TGGAAAAAAAAATCTGAAAAATCCCACATTTCCAATAAAAAAATTCCAAA +AAGCTTTCAGAATACTTGTCTACCTCGAAATATCCTAAAATTCATAACAA +TTTCAAAAAAAATATAATTTGGAGCAAATTAACGGGCTATTTCAAAGTCT +AAAAGTGAGCTATAATGCATACATTCCAGAAAATGGAATAAAAAATAAAC +TGAAGTCAATTTAATCTAATCTCATGATACCTCCTCCTCCTTCCCCCAAC +AAATAATGCTCAATAGCCCCCAATCAACTCGTTCCAATTTGAATAGTGTA +TTATTTAACAAGCTTCATCATCTCTTCCTCCTATTTTTTTTTGTCATTTT +TATCGTCCCCTCGGCCGTTTGTATTATCCTCTCTTCCTTCTTCTTCTTCT +TCTTGAAAACGAATTGAATTTCTTCATCCAATTCACTCAAATCACATCCT +CCACGGACACATTCAATTAATCCAAACGTCCTTTTCAATTGAACACAACA +ACAATCACTATTTCATAAAAATTGTTTTAAATGTACATATATCAAAAATT +GCGACGGCTGGAAAAATTAAATTTTTACACCAGAAGAAAATTTGTAACCA +TAGTTATGGTAGCTATAACTCAAAAAAGTAGGAAAATTATGTGACATGTT +CTCAGGACTGCAGTGATCGCAATAAAAATAAATTCTGCTGATCCAATACT +CTTGAAATAATAAATCGTTTCTGATTGATTCCATCATTCTCAGACAAATG +GAGCTTGGTTGAGTGCTCAATTGGTCAATGTCGCTGTCATGGCACCAGGG +TTGTGCGGCATCCGGATTTTCTGGCAATCGGAAATTGCCTTTTGCCGAAC +TCTAATTTTTTTTCGGCGATCGGCATTTGACGGTTGCCGAAAAACTCGTT +TTTTCGTTTTTTCGCCATTTTTCGGCATTTTTCGGCGTGCTTAAACTCTT +TGAGGTTTTTTTTTTATTTTTTCTTGTATTTTATAAATCTAAATAATTCA +ATTCCAAAGTTTGATAAGGAGTGTCTTGGTTTAAATTTTCTAGCACAGAT +CAATTTCATTTATTAACGATCAGACTGGTAGGATAGTCAACGACCCCAGA +GGCAAGAATGATTCAAAATAATTGCACACATGGACAGCAATAGACAAAAT +CTTTGAGAGTTTTATGGTGGGGTGGCGATGTGTCGACCAAAAGAGTATAT +CCACTATATGGCTAATAATTCAAATATGTTGTATTTTGGAAAGTGTTAGA +ACACAAGTGACTTGAGTGTTTTCGGATACAAGAGACACAGAGATGTCCCT +TGATTGTTCACAGAAAGCGATTTTTAAGGGTTTGACTACAATATTTGCGG +ATTTATGTTTCAACGAATAAATGTAAAAAACTCGAATATCATTTACTATA +TATAAAGCGCTTATTCCGTTTTTCCATAGTTTGTAGTCTATGTAGTCTTT +GTAGTTTGCGTAGTTTTAGCTTCTGGAGGGATAGTGAGTTGGGGTTAGTG +TAGGGATATAGTCGGCGTACTGTAGTGGTACAATGGTGGTACGGTAGGAG +TACTGTATGATTACGGTAGTCTCAGAAAAATTGGTTTTCAGCTCCAGAAG +TCGGGGACCGCGCCGGAGGTGCGGTCCACGGCTGGTATATACATATGTAT +ATGTATGTATATATGTATACATATATTCAATTAAATTTAATTTAAAAAAT +AAAAAAAACATTTCTCACAAATGCCGAAAACACCGAAAAATGGCGAACAT +TTTTAGGCATTCGCCGATATTTTGACCAACTATTTTTTTTTGGCGAACGG +CATTCGCCGTTTGCCGCACAGTCCTGCATGGCACCCCGACCGGTTTCGTG +ACAATAGTTTTGACCTGAACGCACTAGGAGTCAGGAAGTTATAGGGGTCA +TGGGTGCTTTAATGACCCCCTGTAAAAAGCACATATATTGACAACAAAAT +TTGCTCGCTGTTTTTTGTATTAATTTTTTGTCTCCCCTCGATGCGCATTT +CTAGTAATGATGCACATATTTATTTTTTTTCATGTACATATCTAACAAAA +TCATAAAACTGAAAATTGCGCTTTTGTTCAAGTTAGCAAGACAACCATTA +TAAAGCTTTCCAAATAGCAAATTAGCAAAATAAAGTGAGAAGCTAGAAGA +TAATGGGGAGTCCCTATAATCTTTCGGGCACACCTTCAGACTTTGTGACT +ATAATAGCCCAAACCCACAGTTTACTGAAAACTAGGGCTTCATTTGCTAT +ATGGTACCCCTAAACTCTTTCAGTAATCGAATCCCAAGAAACCTTCACAT +CTGTAACCTGGACAAAAAACACACAATTTCAAAAATATAGAATTCTTTAT +TCAAGAATCATCATCATCATTTTTTTCAATTTGTACAGACAAATGCCGAC +CATATTTTTTGTCAGGGGAATGGCAACGGCGGGAACCCAAGAAAATCAAA +CAAAAATATGGAGAGAAAAATGAGCCAGAGAGCCTGAGCAACCATGCATA +AATAATGAGGAGTTGGTGAGATGAAGAAAAAACAGATAAGTTACGACGCG +AGGAACTATTTGAAAAATAAACTGCTAAATACTATGTGCTTAATCCTCCC +AGGTAAGCGAGTGACGGTTCTCGTATCTCAGCTGGCAGTTTCTCTTTCCG +TACCAGTTGACGTAGGCGAACTCGGCGTCGGAGACGATGGCGTTGAAGCG +TCCTCCGAACTTGGCCGAGGCGTCTCCCTCGATCTTTCTGGCGGCCTCGA +GGTTGTCCTGGAAGGTATCAGTGATTGGATTTGATTTATAGTTCTTCTTT +TTTTTCTTTAATTTCTTGCTTGTAATTCTAAAGCAACTAGAAAAAAAAGT +TTCGGAACGCATCTATCATGCCAATTTACATAACCGGTATGGGTTTGCGC +GCGCGGGGGGCTTGCAACATTTTCTTAAATGACATTAAGGTATGAGAGGG +GGGGGGGGTGTTGTAAATAGGTATCCAGTTCTTGTCTGTCCCCGTTATCA +AGTTTCTCTGGTGACGCAACGCAAGAAGGCAGAAAACAAACCTTCTCGTT +CTTCAAAGCGGCCTCAACGATGGCGCGGAGCTCTGGATCGTCGCAGTTTC +CCTCGTCTCCTTCCTCATCGGCGTACTCGACAGCTTCGTTGGTCTCCTGG +AAATTTAGAAATTAGATTTTTCTCGAAATTTGGCCGAATATTAAAAAAGT +AATACTAAGAATTTCCCCACGAAAGGCTGAAAAATTGAGGTTTCCTGGGA +AAAGTGAAATCCCGGTCTCAAAATTTTTTTTGATTTTTGAGCTCCGTTGA +ATACCGACAACAAAAATGGCTCTGGAATTTGAAAATTACGGGGAACTGAA +ACGCAACTTCTACTGCTGCCAGTATGTCTCTCCCGCATTTTTCGGAGGCT +CAATCGTAGATCAAAGTTTTCCGAATAAGTTACTATTAGGTTTTTATCGA +GAATTGGTACTAGACTATGTTGACAAATACCAAATATCAAATATTTACCC +AGATGCAAGTTATGGTGCTTTGAACTAGAATTCCTGGGAACTGATTGTAA +GTGTCAAAACCTCAGCCAACCGACCTAAGCCTAAGCCTAAAAAGGTGTAT +CGAACTTAAATTTCGACATGGCATGGCATTCAAATGGGTATACCGATGAT +TTTGTTTCAGCAAAATTTTTAGGGTCGAATTTTTAAGGTAGAGCAAAATT +GGGATAATTTTAAAGACTATTAATTGTCCAAAAATCCAACAAATCCAACT +TCAAATGAGCTTAAACTTTAGATCACCTTCCCAAAAACCCACCTCAACAG +TATCAACTTGCTCGGTGGCGGTCTCGGTGGCGGTGGATGGCTGCTCCTCA +ACAATATCATCATAGGTGCTCTCCTCCTTGGCAGCGGCAACTGGAGCCTG +AGTCTCCTCGACAACTGGAGCTGGAGTCTCTTCAACGACAACTGGCGCCT +CGGTCTCCTCGATCACAACTGGAGCCTCGGTCTCAACGACGGCTGGGGCT +TCGGTCTCTGCAACGACGACTGGTGCTTCAGTCTCAGCGACGATTTCTGG +AACGATTTCCTCTTGGACAGTCTCGACTACGGTTGGCTCTGGTGCTTGCT +GTGGTTCTGGTGCTTGTTCTGGTTCTGGTGCTTGCTGTGGCTCGACAACA +GTCTCGACGACCTGCTCGACTGGTGTTGGGACTGGCCCCTGGGTGTATGT +GGCGACTGGTGCGACTTGCTCGACAACTGAAGTGTGGGTGAGGGTGAATG +TGTGGGTGGGAGTGGTGCGAATCTGACTAAAAACTGTAAAAACTAACCTT +GAACAGCCTGGTGCTCTGGTGGAGCTTGGTAGTTTCCTCCCTGAGAGACT +TGGGTCACCTGGATAGAGCTGACTGGTCCCGATTGGTATCCTCCTTGTTG +AACTTGCTCGACTGGGGCAGATGGTCCGGCGTTGTAGCCTCCTTGTGGGG +CGACTGGGGCTGGTTGGGAAGCTCCAGCGTATGAGGGTCCTCCTCCGATT +GGTCCTTGGGATCTAGCGTATGAGGATGCTCCGACAGCTTGGGAAGCTCC +AGCGTATGATGGTCCAGCTTGCGATCCAGCGTGCGAAGATGCTCCTCCTC +CGATTGGTCCTGGACCAGCTTGGTAGGCACCTCCACCGACTTGTCCTCCG +AATCCTTGTGGTCCCTGGGAGTACGAGGCTCCTCCGACTGGTCCAGGTCC +TCCGAATGGAGCGGCATATCCGGCTCCTCCACCGATTGGTGCCGGTGGTG +GTGGTGGTGGGGGTGGAAGGGCAGGCGCGGCGGCATAGCTTCCGCCTCCG +CCTCCGGTTGCGTAACTGTAAATGAACACATTGGGAATAGTATGGAAGAG +GTGGCTAAAGGGGGAAGCAGGTTTTAGTTTTGGCGGCCAGCAGCAGGAAA +AAGGACATTTTGCATGAATGGGGTGGCAAGTAGAATGGACTTTGTCGCTC +CTTAAGGAAGACATCAAAAGAACTTCAGAAAGAAAGAAATTATTTTTGGA +ATCAGGAAAAAGCATTTGAATAGCAGTAGAAAAAATATAACAATATAGTC +ACAAAAATACAAAAAAAAAGGCAAAATCTTACCTCGAGCTAGAGCATGGT +GGAGCTCCTCCTCCGCACGATGGCTGGGATGGTGGGCAACATCCACCGGC +GCTTCCGGCACCTCCGATACACGCTAACGCAGGCGACACGGCCAATAAGA +CGGCTACCAAGACTCTCATCGTTTTTGAGAAGGCAGAAATCGCAATGGAA +TGCTGAGTAACTGTCGTCGAATGGCAACGTAGGACGTGCCTTTTCTACCT +GCCACCCCAAACTAACTCCGCCCATGGCCGTCTGGAGGGGGCACGCGCGC +GCACGAAGCCTTCCGAAAGACGCCCGATCGCGTTTTATCGATGATGATGA +TGATGATGATGAGATGAAGCCTCTCTCTCTCCGTCGGAGGGCACCTTGCG +ACATTCACCTTGTGTGCGTGTGTGTGTTGCAGAATAGGGGGAAGAAGAAG +CGATCGCGTACAAATGGGGTTCGTGTTCATTTCCGAATGATCCAATGATC +AGCTGGAATATTCCTATTAATGTGACTCGTGCCACGTCATTGTTAATGAT +CTACTATGTTTGAGTGATTGGATATGTGTTGTTTCCTTTTCTAGTTAGAT +TCCTGAACAGTTCACCTTTACCTAATCCGTGATCGATGTTCCAATGCTTC +TTCCTTTCACTTCCACTGCGGCACCTAATCAGGCGGAATAACATGCTTTC +ACTCTGCCGGTAAAGTGTGAAAATCCTAAAGTTTTAGATTTCAAAGATTT +CAAAAACGATCGTTGATCCTACCGCGCTTCCGCATCAACTGATATCAGGT +TTTTTTTAATGATAAGATTGTGGAGGAATGAACTGGTGAACTTTTAGGCT +GATTTAGAGCCACGTGGAAACTTCCAGCTTTTACCTAGGTGACTACAAAC +TACGGAAGATCAAATTACATACATTTTGTAAAAACATACATCACTTTCAA +AAATTTCGGTTTAGTTCAAAAAATCACATTTTTACTGTTTTGAGATTTTT +TTTTTCCCAAAAATGTCGATGCAATTTTGATGTCGATGCACCACGGGCGA +TTTAAAGGAAATTATCAGTTTTCTGAATATTTTTGTTTTGTATGTCTTGA +TTATGGGTTTTGTAGGCTTCGATGGCAGGCAGGCGAGGTTTCGGGTCCTG +GCGCCCGTCTGAAACCTGCCCGCTTCACGCCGGCCTTTTGCCTCTTTTTT +GCATTTTTACGTGGTGCCAGGCTGTCCCATCGCAGTTTGATCTACAAAAA +ATACGGGAATTTTTCGCCCAAAAATATGTGACGTCAGCACGTCTTTAACC +ATACGAAATCAGTTGAGTCTCTTCTCCCGCATTTTTTAGTAGATCTGTGT +AGATCAAGCCGAAATGAAACACGCTGACACCACGTGTGTTTCTCATTGGA +AATTGGAGGCCTAGAAAATCAAAAGTTAGGCCATCAACAGATTTTTGTTT +CAGCAAAAGGCGCGGATTGAGGCGAGGTCGCTTTAAAGTCAGGCAGGCAG +GCGGTTAACGCCTACAGGAAAACTTTAGGTTTTAGGTTATCTGTATGTTT +CCCTTTTGTGTGTTTTTTAGACGTCCAAAGAATCGTATCAAAATGAATAG +GTATTTTCTCGTTTTATGCAGATAGGTAAAGGTCTGTAACCTGAAAATCC +AGAGCCTTATAATCCACACCTACATAATCATCAATTAAAATATTCAGATA +ACTGATAATTTCCTGAAAATAAGATATCTGTAAATTGAATCAACGCCAAT +TTTAGACATGGTGCATCAAATGCAACATTGTATTGATATATAAACTTTGG +CAGTCAATACATGTTTTCTTATGCATTGTTCTCAGTGCACCTTGATCAAT +TGAGTAGACTTCATCTATTCTTGTCCACTTCCTAAACATGAAATCAATCA +CGGCACCCCATCAAAAAGCACTAAAAAAGTACATTTAAAAGAGTACATTA +TTATTGCCCGTTCAATCCTCGTAATGTATCTTTGCAAGTTCCTTCTTCCT +CTGACATTTCCCGTTCCAATTCTCCGCCATACCTGATATGCTCGACTTTT +TCGATCATAGACGCGAATTGCGCAACGCGCGAAAATATCTTGCGCAATGA +ACAAGGAGAAGAAGAAGAAGAAGAAGTAGGAGAAGCCAAATAAAAGATAG +GTGATAACCGAGATGTTAAGCCAAAGAGAAGGAGTGTAATAGCTGAACAA +GGCCTATTTTTGTGTAACTCCCCCCTCTGACAGCTTCTTCACTTTCCCTC +CAACCGTTTTTACTCTGTATGGTAATTGTTGATGGATCGCCATGGAAAAG +CCCTAATGGTCATGAATAAGCTGTAAAGCAGCGGGGGTGAGCTTGAAGGA +CGATCGGACAAATGAGATATGAAGCGTGAAAAACGGAAAGCATGCTTAGA +GGGGGAGATATATGTAGATTTGGGGAAAAGCTACAAGGTCGATTTTTATC +CGGTGTCAGGATTATAGAGGTGTTTTGAAGTAGAAGCAAGGCACTGAAAT +TCACCACTTCCTCTATTAGAATTGCACATTTTTTAAAACTATGTACCTGT +TTTCTTAAGAATTGCTTGAAAAGTTGAATTTGAACTAGTAGTTCTTGCAA +AAAGGCCAATTGAACTATCTGGTTTAGTTGCGTCCTTATTAATATTGCAC +TTTTTAATTCCGGCAAAACGCCGGTTTACCGATTTGCCGGGGATTTTCAT +TTTTGGCAAATCGCCGATTTGCCGTTTGCCGAAAAAATTTTTAACAGACG +GAAAAACTTAAAACTGTGTCATTTTGAATTTATTACCGTTTTCTTTAGAT +ATTTTCATAGAATTTGCTAACTTTTGAAAATAGATGAAGGAACATTTATA +TTATTTGAAATTGAAATTCTGAAACTTCCAAAAAAATAAGTTGCAAAACC +ACAATTTGCCGAAATGCCGTTTTCCCGGCAAATTCGGCAAATCGGCAATT +CGCCGATTTGCCGAAAATTTCAATTCCGGCAATTTGCCGACAAAGCAATG +TTTCATAATACATAAAATGTTTCTAATTTTTAAGAATGATTTTTTTAATT +TTGACAAAGTTTTTTTATAAAAGAGCCGAATTATTTTAAATTCCCGCGCA +AATAAGTGACGCCATTTTTTACATTATTTGTATTTTCTGGCTAAATTAAT +TGGTTTATGTATGTTTTTTCTTTAGTTTATAACTTGAGTAAAATTCACAG +TAAAAATTAATTTTGAAAAATCGATTTTTAGTTTAATTTCAATTTCAGAG +TTTCGGCAAATGTATTCTCAATTAACAAGTTTTCCAAACGGAAAAAAATC +TGAAAATTGACAAACCACGGTGTAGATCAAGCCGAAATGAGACACCCTGA +CACCACGTGTGTTTCCCCTTGGAGGCCTAGAAAATCAAAAGTTGGGCCAC +CATCAGGTTTTTGTTCGACTCAATTGGTAAACTTTGCAGACTAGGCTGAA +ACGTGGTATTTGCAAAAATACAATTTTACACATTTATTTTCCACAAACCG +AATAAAATCCTTATCTCAACAGTGTTATATAATTTTTTTTTTCAGATCAC +TATCACGACATTTTAAAATATATTACAGCACTCTCTTCTTTAGGTTTTGA +ACGTTGATGCTTCGAGGATAAACATGAAAACCAGATCAGCTTTTCCGTGA +CCTCACATACTCATTTTCTCAAATTCTCAAAAATGTTCTGCCTTCTCCAA +CGGTCTCTAAAAAAGCTTGGAAAACCCACAAAAGGTGTCTTGGGACACTT +CTGTCTCTCTCTTTATCGATGACCGGATCGCCCGGATAAACGGGTTTTGC +GGACTGACACCAGCAGGTGGAAATGGGCACACTTGTAAAATAAAACGAAA +AATAATAATAAAAATAACACGGAATGCGGAGAGAAGTGGCAAGATCGGAA +GAATGGTGGGGGGGGGGGGGGGGGGGATTACATAAAGATGGCGGCATAAA +GTGCGTTTCATTAGGGGGATATTGGGGTTTTTATAGGGGGAAACTTTGAT +TTTTTTGAAAAAAAAATTAAGAAAGAAGCGACAACAACCAACAACAAGGT +CATTTTTAAAAGGAAAATTTGGCATGAAATTTACATTTTGGGATGAATTA +TGAGGATATACTCATATAACCTAATTTTGTCACAAAAAAAACGTCGAAAT +TTTTAAAAATGACTACATTCTGCAATTTTGAAAAATTTGGTGGTCCTACC +ACGAAAAATCCATGGTTTTTTGGTATTTTGACGAAAAACTGATTTTTTGT +GTTTTTTTTCTGGTATTTTGAAGCCGCTGTACTTCAAACCCTTTTCATAT +TCTAAAAATATCTTTTTGCAAAATTCGGTTTTTTCTAAAGTTCAAAATAA +ACCACTATTTTCAATTTTTAACGGAAAATCTGCAAATAAAATTTCGGAAA +ATTCCGGCAATTTGCCGATTTGCCATAAATTTCAAGTTCCGGCAACTTGC +CGATTTGCCGATTTGCCGTAAATTTCAAATTCCGGCAAATTTGCGAATTG +CCGTCCTACCATGAAAAATCCTTTTTTTTTCTGGTATTTTGAGACCGCCG +TACTTCAAACAATTTTCATATTTTACAAATATCTTTGAGCGAGCGGTTTT +TTTTGAATTTCAAAATAAACCAAAAGTCTACTTTTTTTGGTTTGTTTTTG +TAATTTTTTTTTTAGAAATTTCAATTTTTATCGGCAAATTGGCAATTTGC +CGGTTTGCCGGAAAATTTCAAATCTGGCGATTTGCTGCTTTGCCGATTTG +CAGGAAATACCTATCCCTGATGTAAATTACCAGAATTAGAAGTTTGGTAC +ACGATTGGCACACAATTTTTTGGTACAAAACACGCTAAAAATTAAATGTT +TTTGAAAAAAAAAATTCTTTTGAAATTGTTTTAGTGTGAATTTCCATGTA +TTCAATTTTTATCATTTTTAGCCTGTTGCTCCAAACTAGGTTTTCTCCCA +CGTGGCATCTCTCATTACACATAAAAATACCTGCTAACTCAAAACATTAA +TCAGAGATCCATATCCATGTCTTCCTCACTTTCCAACTTTTTCCCTCTTA +GCTTATCTAGATATATGTAGGTATATCTATATCTACAAACAACTTTCTCT +TTTCAAACATCCAGTTTATCTTCTGACCTTTGCAACATTTTTCCTTTATT +CCAAACTTCCGCCAGATTGCATCTTATTCAATTATTACATTCAAAGAGTG +TCTAAAGTTTTGCTTAGAAGAAACAAAAGGTAAAATGTCAGATATGTTTA +GAGAAGGTTGTAAAATTTGGCAATTTATTGTAAAAATTCGCAATTTTGAA +ACTCCTTTAAAATGGTTAATTTTGTAGTTAGAGGACTCAAAATTAATGCC +CGAGAACTAAAAAGTTGTCATTTTTCATTTATCAATGATTTTACTTAATT +TCAAAAAAAAAATTTTGCCCAAAAAAGGACAGTCATTAGAAAAAAAAACG +GAAAAATGATATGGAGTGATTCTTTTTTATTTTATAAAATTAATCAGCAT +AGTCAAATGTACCAGAAAAAAGCAAATAAAATGTACTAGATTGACCGGAA +GATTATTTGAAAAATTGCAGAAAATGCACCAAAAGCTGCTTTTTTCAAAA +ATTCAAAAGTACGGTAAAATCATACGGAGCTATTCTTTTTTATTTCATAA +AACTCTTCAGCATAGTCAATAATACCAGAATATGTCAATCAAAGTATAAT +AGCTTGTACGGAAGTATCTTTTTAAAAATTGATAAAAATATATAAAAGCT +GTTTTTTTCAAAAATTCAAAAGTATGGGAAAATCATAAGGAGTCATTCTT +TTTTATTTCATAAAACTCTTCAGCATAGTCAAAAATACCAAAATATGTCA +ATCAAAGTATAATAGCTTGTACGGAAGTATTTTTTTAAAAATTGATAAAA +ATATATAAAAGCTGTTTTTTTCAAAAATTCAAAAGTATGGGAAAATCATA +TGGAGTCATTCTTTTTTATTTCATAAAACTCTTCAGCATAGTCAAAAATA +CCAGAATATATCAATCAAAGTATAATAGCTTGTACGGAAGTATTTTTTTA +AAAATTGATAAAAATATATAAAAGCTGATTTTTTCAAAAATTCAAAAGTA +CGGGAAAATCATAAGGAGTCATTCTTTTTTATTTCATAAAACTCTTCAGC +ATAGTCAAAAATACCAGAATATGTCAATCAAAGTATTATAGCTTGTACGG +AAGTATTTTTTTAAAAATTGATAAAAACAAATAAAAGCTGATTTTTTCAA +AAATTCAAAAATTCAAAAGTATAGGAAAATCATATGGAGTCATTCTTTTT +CATTTTATAAAATTCTTTAGCATAGTCAAAAATACCAGAATATGCCAATC +AAAAGATAATAGCTTGTACGGAAGTATTTTTTTTTTAATTGATAAAATAT +ATAAAAGCTGATTTTTTCAAAAATTCAAAAGTACGGAAAACTATATGGAG +CGATTCTTTTTTCTGTTATAAAACTGTTCATCATTGCCACGTATACCTGA +AACTACCAGAAAAAGTATGCTAGCATGTACGGAAGATTATTTGAAAAATT +GCAGAAAATGCACCAAAAGCTACTTTTTTCAAAAATTCAAAAGTATGGAA +AAATCATATGGAGCGATTCTTTTTTCTTTTATAAAACTGTTCAGCATAGT +AAAATGTACCAGAAAATACCAAAAAAAAGTATGCTAGATGTTCGAAAAAT +TGTTTTTATAATTTTTGAGAGGAGTTTCAAAATTGTGAATATTTACAAAA +AATGGACATTCTTGCCACTTTTTACTAATTTTTGATGGGCTAAACCTAGA +TTTTCTAAATTTTACATTTATGAATTACCCGTTTTCGACGAATTCAGGCA +AATTTTTATTTTTTCCTATTTTTTTCAGCCATTTAATCAGCCATAATAAT +GAATGTCCTTTTTTTTTGGGCAAAAAAAAATTTTTTAAGGCTCGAAGACC +AATTTTAAGTTCTCTAGCTACAAAATGAACCATTTTAGAGGAGTTTCAAA +ATTGTGAATTTTTACAAAAATTGCCCAAATTTGCCACTTTGTAATGGTTT +TTGGTGGGTTAAACCTAGATTTTCTGTATTCTGCATATATGAATTACCCG +TTTTCAACAAATTTTGACAAATTTGTATTTTTTCCAAAATTTTTTTTCAG +CCATCTATTCCTTTTTTTTGTCTGTTTTTTTTTCGGGCAAAAAAACCTTT +CCCCACTGGTGCTATACCACCTTTAACGGTAAATTTTACTGGTCTAAAAA +TCGGCGAAAAAATGAAACTTCAAGTAATATAATGGTAATTGAGTTTTTTT +TTCTATTTTCTTTGTTCAAAATATCAATTATGACAAAAAACGAGAAAATT +ATATTGACACAGTTAAGCGGATATAAATAATAAAACATCACAAGCACATT +TAATTTTTCAAACCCCCTCAGGAGTCATGAAGAAATCCTTCTCTGCACAT +CTACCTTTCTCCACATCCAACTCCTGATTTATTTTCTCCGCAAACTCCGT +GTAACTTTTAATTGCAACATTCAAAAGTTTTGTATGATGCTTCAAGTGAC +CCAAGTCGATTACACAATCCCCGCAAAGAGCTTCGCTGCGAATTTTGTCA +ATTCCCTCTTCTAAATTCACTTGTTCTCCAAACTTCACTGATTTCCTTAG +GATCCCAGTGCTCAGGCAACAGTTTGTGCAAATTCTCAAGGTTTTTGATT +TCAGTTGGCAAGCGGTGCAGATAGGGCTCTGGAATTTTAAATTATTGATT +TTTTTAAAAATTATTAACTCACCTCGTCGCTTTCATGTGCTCTTCTTGGA +TTATGGTCATATGGAACTAAGAATCTCGAAAGTTGTATTAAATCCCACAA +AGATCGATTCACATTTTTCCTTTCAAACGCATTTTCTCGTTTACAGTGTG +GACATCTCTTGTTCAGTAGTTGGAGTCGGCATCTGTCGCAGATAGTGTGA +CCGCAAGTGCCTATACAAGGGATTTGGGTATCATGATCTGGAAAATTTGG +TGTGTAGGGCTTCCATGGTAGGCAGGCGCGGGGCCTGGCCCGCCTCACAC +CGGTGAATTTACAAATTTTTGATTTTCTCGTTTTTGTCATTTTGATGAAA +AACATTGAGGCAGGCGGAGGTCGCCTCAAGTTCACTCGGCGTTTGCCGCC +AGCTTCCTACCCAAAGCTTTGCAACTTCTTACCCAAGCCTTGCCCAAAAA +ATAAAAAGCTTAAATATCAAAATTACTCAATTTTGTGTCATTCTACTAAT +TTTCTGAGAAAATTTGAATTCCCGCCAAAAATTTTATTGGAAAATTTGAA +CTACTGGCCAAAATTTTTTTTGGCTGCGCCAAAGATGATCTTAGAAATTT +GAATTCTCGCCAAAATTTTTCCCAGAAATTTGAACTTCTTGCCAAAAATT +TTTGTTGGATAATTTGAATTTCCGGCAAAAATTATCTTATAGTGAGGACA +CAATCAATAGTTTTGGTCAAAATTGTATTGTCAAATTTTTGATGTGTGTT +GGCAATTTTGGCAAATTTGCCGAGCTCGGCAAATTCGGCAAATTTGCCGA +GCTCGGCAAATTCGGCAAATCTACTTTTTGAAATTCGCCAAATTTGGCAA +ACGGCAGAAAAAAGTACAATTGAGATTTGAGGTACACAAGACTTACATCG +AAATTAATCTAATTAAAAGAATATCACTTACCATATTCATCATAGCATAT +ACTGCATTCAGTAACCTTCATCGCAAAAATAGTCTAGACACTGACCAAAC +ACTACACACTTGATGCTATTTATATACTTTCTATGCTGAGCAATACAGAA +CATGCGATGTGAGGAATCTTAGGTAGCAGAAGTACAAAAAGATTGACATG +TGATTAAATTCCTAATTTGTTCCTTATCACATTTCCCATATGTCAATTAA +TTCGTAGATAGATGCTATTGATAAAAGTTTTTCGAGAATTTGTAAGATAT +GAAAATAATATTCCTCATTTTTAATTTAATGATACAGTACTTTGAAAATT +TCAACAATTTCAACAATTTTTAACACCTATGTTATCATTCATATACAACA +ATTTGTTTAATACAGTAATACATTTCCACCCACGTGGTATTAATACAGTG +TTAAGCTTGTTATTTTTTAAGGAAAAATTTAGAAAATTTTTCTTCCTCAT +TTTGCTTACTTTTCAAAAAAGCGTGCAACTCCCTCATTTAAAAAAGAAGT +GTCGTCGCTGAGGAAAATGTTAAAAATTTCTCTCATGGTGCTAAAATTAC +TAACTAAAAACAGTAAGTATCGTAGCGAAACATTTCAAAAATTTTCAAAA +TTTTTTATTTATAGTCAACAGTTTTGGAAGTCAATTAAAAACATTTTTTA +CTATTTTTAATATTTAAAAACGTTTCAGTTGCTTGTAACTTTATAAGTTT +GCCTACCGTACATTTACCGTAAAACAACCTTAAAAATGTAAGCTTTTCTC +CCGATAAAAATCTTTACTCAGGAGTTCGCGACTCTTCTCTTACATTAATT +TTTTCTCTAATATATTGAGCTCAAACCTAGCTGTAAAATTGAACATACAT +ATAACTTTGAGTGCAATTTAAATTTCAGAAAACTTTCACAAACCCAAAAA +TTGAGAATGCTCAGGACAGTTTGACCTTTCAAGAAAATTGCTTCGAGAAA +ATTCCAAGCTTCACAAAATTGCTCATTGCCAAGTTATTTCCTTTAGTTTG +TGGCCAACGCCTTAAAAAATACAAATTAAAAAAAAAACTCTGACACCACG +TGATGATGCAATCAGACTCACGAACTCACGGGGTTCTGCCCTTCCTCATT +GAATTTTTCGCGCTCCATTGACAATCACCCGCCGTACAACACGTGGGAAA +GTCGTGCACTCCACAAGGACAAATACATTTAGTTTTACAACTAAAATCGA +GCCGCGACGCAACACGCAACGCGCCGTAAATCTACCCCAGATATGGCCAA +GCCGAAATGGCCTAGTTCGACAAACTCTTCCATTTCAATTTATGAGGGAA +GCCAGAAATCCGTGCGAACTGCGAGCCTAACGCTCTTTTTCAAAATATCG +TATAACTCGGAAAACAAGCCATATTCCCAGTTCCTGTTTTATTTCGAAAA +ACAGATAATACAAAAGAAATATCTGAAAATTAAGAATAACATGTTTTTAT +TAAATACTTCTTTGTCTATATTCCATATAAAAAGAACCCCATGCGAATGA +AACACTCACTATACATTCAAAATGAATTTCGCCATCTACCTTCTCGCTTT +CATCGCCTGTCTCGCTAACTTTGGATTTTCACAGGGTAATCCAGGACTCT +CATTTGATCCAGAAGAAGATTCAGTAAATATTGTAAGTTTTCGGATTAAT +GGTTACAACATCTATAAGATTGTTTAGAATGGCAAAGTGCCAGTGGGAGC +AGTGAAGACGTTGGTTAATGATCTTGTGAGCCCTACTATTGCAATTGTGG +AGAAAACATTATCCTCATTGTCAGTTTAAGGAGCTACGGGAGGGCTCCAT +CCATCTCAAATGTTTCAAATAACTCATATTGTTCTTTTATCTGGGAGTAA +ATAAATTACATATTGGGAATCCTTTTCTTTTTGTTGTTAACCAAGTTGCC +GGTTGCCAAATTTTTTTGGGTTCGGCAACTTCGGCAACTGCCGGTATCAA +TGTCAAACATTTTGAAGCTTAGAAAAAAGCATTCAGAGAGCCTGAAAAAT +TCTATAATTTCACTTTAAACGAAAAAAATACCATACTTTTTTACCAAAAC +GCTCAAAAATATAATTTCAACAAAAAAACATTGAAACCTGGTTGCCGAAT +TTTTTTGGGTTCGGCAATTGCCGGTTGCCGTTAACCTCGGTTGCCGCACA +GCCCTGATGTGGAACTCTGCAGGCCTAGCGGCATCCATGTGAAGGAAGCG +TATTGTATTTATTTTTAAACATAAATTAAAAAATCGATAAAACCTTCATA +TATATAAATTGTTTAGACCGGTGAATAAAATGAGACGATGCCACGCGAGT +TGGCGAACGCTTTTCTCCGAAGATCCAAGTCAGGACGTCGTCGATGGGCG +GGACCCGGTGGGCGGAGCTTAGTCGGATAGCGCAGCAGACAAAATACGGG +CGGTGCGTCGAGATCAAGTGCGTACTCCTCGACGGAAAGGGAGCTTGACG +CGTGGATTGCGTTCTCGTCGGATGAGGAAAGATCTTCTGAGGAGGCGACC +GGAGCCAGTGGTGGGAGCTCTTGTAAAAGGCGTTCTCTGAAACAAATAGT +GGTGTTAAGGGGAAATGCGATGGGAAATCCGAGTAGTTGATGTCCGCGGA +ATTAATTTTCTCGGGGTTTCATGGAAATTTAATTCCGCGGATTTCAACTT +GCCGAGTTTTTATTCGATTTTATGAAAAAAATTACACGAGAAATTGTTTT +TTTTAATTAAAGTATCCGAAATCCCCGGAAACAGATTTCCATAGAGAGAG +GTCACTAGAGGTTTCATGGAAATATGTATTCAAGGTCTTAAACTACCCAA +TTTTTTTACCTCGATTTTAACAAATTTCAAGTAAATTTGAATAATTCTAA +CCAGTTTTGTTGTTTTACACAAAAATTCGGGTTCTTTAATCCGCGGAAGT +AGCTTTCCAGAGGTTTCATGGAAATATGTTTCCGGAGATTTCAACTACCC +GAGTTTTTTATCTCGATTTCACACATAATCGGCATAAGAAACTACAATTA +TTTGTTTTCGGGGAAACTTTAAAAAACCCCAGAAAGTTGAATTTCTAGAA +ATTAGCTTTCCCGAGGTTTCATGGAAATTTGTTTTCGCGGATTTCAACTA +CCCGAGTGTTTTACATCAATTTCATCATAATTGACATAAGAAACTACAAT +TATTTGTTTTGGGCGAAAGCTAAAAAATCCCCGGAAATCTGGATTTCTAG +AAACTAGCTTTCCCGAGGTTCATGGAAATTTGTTTCCGCGGATTTCAACT +ACCCGAAATTTTAATTCAATCTTTAAAAAACATCCAGTTTTTGTGACATG +TTCTTCAGTTAAAAAAAATCAGAGTGTTGGAATCCTAAATTTCTAAATTT +TCATAGTTTCCGCGGATCGAATTTCTAGAAATTACCTTTCCCGAGGTTTC +ATGGAAATTAGTTTCCGCGGATTTCAACTTCCTGAAGTCTTCATTGGATT +TCAATATAATTCGCACAATAAAAAAAGCCAAAACGCGAGGATCCCTGGTA +GTTGAAATCCGCAAGAATAGTTTTCTCTAGTTTGAAAAATTTACTGAAAC +CCTTACTTTTGCTTTCCCAAGAATTCGAGTTGTTCCTCGAACAATTGCTT +TGCAGTCCCAATATTCGGCGAAAATTTCGATGGTTCACTATTCCGACGGT +GCTCTTCAATTTTTCGCAAGTTTGCTGATACCTGAAAAATCGATATTTCA +GACTATCTGTGCCAAAAACTAATTTATTAATTTACCTTCTGACTAGCATC +CTCCAGCTCAACAATGTTATGAATGGTGGCTTTATACTGTTTCAGCTTCT +CCTCAATTAAAGTCTGAACACAACCCGTTTGCCGTGCCACGTCATTCAAC +TGCTCCTGAGCATGAGCACTATCTTGTCGGCGGAGCACACATGGCCCGAA +GATCAGAGCCAAGTTGTTGCAGCCCATTTTGTTGACGGCTTCCTGGTCGG +CGACACGTGCCAAATGATACATTAGGCGATCGAGCACGGCGCGGTTCGGT +TTTGGGAGAAGCTCGATCATTACGGAAAGACAACGGACACGTTCACCCAT +ATCCTCCACTTCTGTAATTTTTTTTTTTGGACGAAAAAAAACAACAAAAA +ATATCATTTTGACAAAATGTTAACTTTCAGAAAATTTGAAAATTGATTTA +TTTTTTTTGTTTCAATTTTTAGGTTTATGAATGAATCCGATTTTTTTTTG +TCGAAATTTTTAATAAGAGCCCTAGTAGGCATGTGGTGTGTGTGTGTCTC +ACTTCGGCTTGATCTACGTAGATCTACAAAAAAATGCGGGAGAAGAGACT +CAGAGTTCTTAATGGATTTCGCATGGTTAACAATATGCTGACGTCACTTT +TCTGGGGAAACAATTTCCGCAATTTTTTGTAGATCAAACCGTATTGAGAC +AGCATCTCTGCCTGGCTGCGGACGCCTCGTTTTTCCCTTGGAATTTTTTT +GGCGCGAAATTCAACTTTTCAAGTAAGTGCGAATATTTTCAAGTGAGACT +GTTCAAAATTATTTTGCTGCCAAATTTGAGTTTGCAAATAAATTATTGAG +CAAAATTCAAATGTTCAAATATTTTCTTTCGAAACGTAATGAAAAAACTC +AAAGTTACAAATAATTTGGCGCGAAATTTGAGTTTTCAAATATTTCTAGT +GCAAAATTTGAATTTTTCGAATAATTCTGGTCCAGAATTCAAAAATTAAA +AAAAAATTAGTTTGAAGCGATGCTCAGGTTTTCATAGAGCTTCCATGTAG +GCGTTAAAACGCCTGCCTGCCTGCCTTATGCCGCGCCTAATGCTTGAATA +TACGTAAACTTTTTTTCATTTCTTAATTTGATTTTCAACAAGTTGATAGA +ATTGAGAAAATTATAAATTTGTAAATTTACTTAAAAATGCAAAAAAATAG +GCAGGGTTCAGGCAGGTGCCAGGCCCTGAAACAGCGCCTGCCTACCATGA +AAGCCTATCGTAAAAAATCCAAATTTAATTTTTAATTTTACTAAAATTTC +GATGGCTCGTTTTTTTTCAAACATCACAAACCTGAAACATTCAAAAAATT +TTCATAGAGATCAAAAATGATAATTGGTTCGGCGAGTTCTCGGAAGAACG +CCTTGACAAGTGTAGTTAGCACATGAACTCCAATATCCTCAAGATTCACA +GAATCCGCATCTGAAACTCCGAATTTGATTTTTTTTTTTTCAATTTTTCT +GCAGTTCAACAATTACCTGCAGTCGATTCAATCACTTTTCTGATACTTCG +AACTTGGGGTAGAGATCCACTTTTTCTGAAATTACGGGCGCAAAAATTTC +AATTTCAAAGACCTTCAGGTATTTCCGTACCTATAAACTCCTTCCACAAA +CAGGGCACGTGTCTCAATTGCAAAAAAGAGTCGGTCCAAGAGTGTTGGCA +CAGTATGATCATCATCGACAATTGATACTAAAGAGGCGCCAAAGAATCTT +CCACCATTTGTCTGAAATTCAATATTTATAATAGCATTATAATAGCATAT +TTGGCTGTAGTTTGTAGCAGGGGTCAGGCAAATTGCCGATGTTGCAAATT +TCCGGCAAATCGGTAAACCGGCAAACTGCCGGTTTGCCGAATTTGCCTAA +AAATTTTTGGCAACTTTTTTTTGGAATTTTCAGAATTTCCATTTTAATCG +GCAAAATTTTACGCATCGTATGAATTTTCTTACATTTATTTTGAAAAGTA +AGCAAATTCTATGAAAACATCTGAAGTAAACGAGAAAAAAAAATTCAAAA +AGGCACAGTTTTAAGTGTTTCCGTCTTATAAAAAATCCCTCTAAACATTT +CCGGCAAATCTGATATCCGGCAAATTGCCGGAATTGAAAATTTCCGGCAA +ATTTTGATTCTGAATTTTTCAAAAAAACTGTTGGCAAAATACAAATTTTA +TTTTATTTTCAAATATGTTTTTTTTTTCAGAAAAGTAAATTTTTTGCCGG +GAATCAAATAATTCTTGAAAATGTTTCAAGATTTTTTTGCCACGAAATCA +GACGTTTTCAGAACAGTTTTAGCGGAAAGTTAAAAAAAAATTTCAAAATT +TTTGGCAGGAAGTAAATATTTTTCAGAACATTTATCCGAACAGTTTTGGC +TGTAAATTCAAATGTTTAGTTTTCAACAACTCTTAGCGGAGAATCCAATA +TTTTTCAGAATTTTGGAAATTAAAAATTTATCGAAAATTAATTGCAATTT +CTAAGAAAGCAGTTGTAATTTTTTTTTTCAAAAAGCTACCGAAAAAATCT +GGCAAATTTGGCAAATTTGCCGAGCTGAGCAAACCCGGAAAAACGCAATC +ATTTTCTATACTTTTTGGATCATCAAAATTACTGAATTCCTACAATTAGT +ACACGTCAGATTTTTCTATAAGCTCCGTTTGGTCTACTTGTATAAAGCTC +GAAATATCTCAATGTTATGTTATTTTACTAGATTTTTTTGGAACAAAATC +AATAATTTCGGTTAAATTATATTGTTCATTTTGTGGTGTGTGCGTGAAAT +TTCAAAATTTGCCGAGCTCGGCAAATTCGGCAAATTGCCGCACACCCCTG +TATTACTCACCTTCGGATCAATCGCCTTTCCAGTCATCTGACACGGATGT +GTGACCTTCGGCTGACACTTTTTATGACACGATATCCGGCACGCAACACA +AGTGTACAGCTTCTCATGGTGCCATATTAACTGATTACACACTTCACAAT +AAGTCGGCACATGGACTGCTTCGGCACGGAATCGGTGACCAGCATGTACC +TGGAATATTGGAATTGCGTGGGCAGGGGAAACTAGTTTCATTGAAAATTT +TTTTTTAACTGCTGAAATTAGTCCAAAATGACATGTTATATGTACTTTTC +TCAAAATGTGTGAAAATTGCACACTGAATTAATAAATAATATTATTTTTG +TAAAAACATAAAAAGGGGAAAAGTCAGCGGTAAAAAAGTAAAAACACTCA +GAGTTAGATCTTTTGACCTCCAAAATCCATGAAAATTTGCTTCATTTTTT +TCATAGCTGTGACGTCGTGGGCGGCAATTTCCGTTCGGTAAATTTATTTT +CGGCAAATACGGCAAATTGCCGATTTGCAGTTTGCCGGATATCAATTTGC +CGGAAGTTTTAAAAGGGATTTTTTAAAAATTCCAAAACACTTAAAACTAT +ACTTTTTTGAAATGTATTTTTACTATTTTCTCTAGATATTTTCATAGAAT +TTACTTACTGTTCAAGCCCACAGCTTGCCGAAAATTTCCGGCAAACTGTC +GGTTTGCCAAAATTGCCGAAAATTTAAGAAACGGCAATTTGTCGGTTTTG +CCGTTTTCTAAAAAAATTTAAATTTCGGCAATTACTGTATTTGCCGTTTG +CCGAAAAACTAAATTTGCCGCCCATCGTCACACAATACAAAAAAATTGCG +CGGCTTCTGGAGATCAAATCTGACAGCTTACTGTATTTATAACTACAAAT +TCACGCTGTGTTTTTCTCTAATTCACGTGGTGTCAGGGTGTCTCACTTCG +GCTTGATCTACGTATATCTACAAAAAATGCGGGTGAAGAGACGCAAGAAT +GTGCTAACGTCACTTTTTTTTTGAAAAAAAAAAAATTCCCGCATTTTTTG +TAGATCAAACCGAACCGTAATGGGACATCCTGGCGCCACGTGCTAATAGT +AAGTCACTACATTCTTACCGCCGCTACATCTGATTTTACACGCTTCTTTC +CAACTTTCTGAATACCAATATTTTACACAATTTTCTCGGATTTTGATATA +TAATACTTTCGCGGGCTTCTGGCTTCCCTCATATTTTCAAATGTAAGAGT +TTACCGAATTAGGTCATTTGGGCTAGGCTACGGCGCGTTGCGGCTCGGTT +TTCATTGCAAAACTAAATGTATCTGTCCGATTGTCATTGGAGCGCGAAAG +GAAAGCTAGAAGCCCATGTATTAAAAAATCGACTTACCTTTATCATTGAT +GACTTCTCCTTCCCGCGCTTCTTTTTCGATTGCACATGAACGTATTCGTT +CAGGAAACCTCTGGAATTGAAAAAAATTGTTTTGTTACAAACGCGCCCTA +ATAACAATTGATCGTGTATTCCACGTTGGAAATTATACAAAATACAATGG +AGCACTTTTGCTCGAAGCCTAACATTTTCTAAATGTTTTCTCACCTAAAA +GCGTTAACGCCAAGTGTTGTCGGAAAGGACACACTCTCCTCGAGACAGAC +TTTCGTTAAAAGTCCCTCGAACATTGTGATGACGTCACGGTATTTAAGCA +CGGATTGCTCGACCTGAAATGATATGTTGCTAATTACACTTGCGTGGCCG +TGAACCCCAAAAACTAGGCCACCTTTTGCGCCCAATTACCGATAAAACCG +CCTCATATCCCAACAGCTCCATATGGAAAGCTCTTAGCGACTTTTTGAAG +ACCGCATCCACTACAGTATCCCTTTTGGCATTACTCTCGTTTAGATGACG +TGTCTTGTTGAAAATAAAAATACTGAATTGTCGGAGATCGTCGGTGGATT +CTACAAGCATGTTTCCAGGGTCGATCTGTAAGTATTGTTTAAGTACAAAG +TACTACTGCTTCAGTAAGCATTGTAGTTTATAGTTTGTGGTTTGTGTTTT +GTAGTTTGTGGAGTTTTTAGTATGTAGTGTGAAGCTTGATATTCATTTTG +CAGTACATTGACTTGGATTGGGGTGTGCTAAGATATAATATCAAAGTACA +AACAACGAGTGACAAATTAAACATCTCAATCCGAAAACTACAAACTAAAC +CCTACAGACTACAAACTACAAACTATATCCTACAGACTACAAACTACAAA +CTACAAATCACAAACTACAACCACGCAAAAGAACGTTACCTACCTGTTGC +TTGGTTTTTGTTAAACTGAACGTGCCGGTCGATGGAATTGGTGAGGAGGA +TTGCCGCTGCTTGTGGGGCCTGGAGTTTCAATTTTTTTTTGTTTCAATTA +AGATTTTCCTCAAATGTTCCTTACATCAAATCCCATGGCCGTTTCGGTGA +ATGCAGCCGAGTTGGTGATCGAACTGGTGACGTGGGATTGCACGGGATGG +AGGAGGCGAAGACGAAGCATTCCTTGTGCAGGCACATTTTGCATCCTGGA +AGAGTTCAAATTACGGCTTCTAGGTCATGGTGGCCGTGGCCGAGGCTTGA +AGGGATGCTAGGTCAAGTCTGACGTCACATGTGGTTTTTCTAGGACACGT +TACAAAGATTTCGAAGCGCCCAATTTTCGGAGAGGTTTCTAGGCCATGAA +AATGTTCTAAATTTCAGGTTTCTAGGCCAGTAGAGAATTTTGAGGTTTCT +AGGCCAGTAGAGAATTTTAGGCCATATCTGACGTCACACTTTTTGGGACG +CGCCTAATAACGATGGTGGACCTCTATTCTAGGAGGAGCAACACATTTTT +TACGAATTTCTAGAAGATGCAACTTCTGCTACTAGGCCACTCATGTGGTG +CGAGGCTGTCCCATTACGGTTTGATCTACAAAAATGCGGGAACTTTTTGC +CCAAAAAAATGTGACGCCGGCACGTTCTTAAACTTGCAAAATCAGTTGAA +AACTCTGCGTCTCTTCTCCCGCATTTTTTGTAGATACGTAGATCAAACCA +AAATGGGACCACACACACACACAAAACCCACTCTGACACTTGTGCGCCTG +TGAGATGAAGTTCGTCAGGTGCCGATTGCAAAGAGCACATATCTCCTGCC +GATGAAGTCGTGACATCTTGAATTGATGGTCTTTTGCGACGAACACGTCC +GGCGTCAGTTCACTGGCAAAACTTGGTCCCGGAGACGGTTCATCCTCGTC +CTCGTTCCTGCCAAAAAGTGCCTTCAAATTCTTTTTTGCCTTCTGGAATC +CCAACTTTCCAGCGCCTCCTTTCTTTTTGGAATGTGTTGGGCTTAGCTGA +AAATTCAAAAGTTTTTAATATTATAAGTAGAACCCTTACCGTGAACGAGT +CATCACATCTTGACATTGAGAAATTGTTGGATTCGGTACTATTAGCCCTC +CGTAACATTTTTAATTTGGTGGTTGAAGCCGTAGGGGCCAGAGATTGCCG +TCTATGATGGGATAGATCAGCTCCTTCAATGAGCTTCAACTTTGTGTCTT +CCAGGATAAATGTGGCGTCCACGTCGACGGCGTCATCGCTGAAAAAAGGT +TTGCGTGTTACGGTAAGCGAGAATTATGGCAGAGGTGGGCGGAAATTGCC +GTTCGGGAAATTTTTTGTCGAAAAATTGCCGGTTTGCCGAAAATTTGAAT +TCCGACACTTTGTCGGTTTGCCAGAAATTTTCAATTCCGGCAATCTGCCG +ATTTGCCGGAAAATTTCAATTTCAGCAAGTTGTCGATTTACCGGAAATTT +AAATTCCGACAATTTGCCAATTTGCCGGAAATTTCAATTCAGGCCATTTG +CCGATTTGTCGGAAATTTCAATTCCGGCAATTTGCCGATTTTCCGGAAAT +TTCATATCCGGCAATTTGCCGATTTGCTTGGAAAATATCAATTCCGGCAA +TTTGCGAATTTTCCAGAAAATTTCAATTCCGGCAATTTGCAGATTTGCCT +GGAAATTTTCAATTCCGGCAATTTGCCGATTTACCGAAAATTTCAATTCG +GCAATTTGTGAATTTTCCAGAAAATTTCAATTCCGGCAATTTGCCGATTT +GCCTGGAAAATTTCAATTCCGGCAATTTACCGATTTACCGAAAATTTCAA +TTCGGCAATTTGCGAATTTTCCAGAAAATTTCAATTCCGGCAATTTGCAG +ATTTGCCTGGAAATTTTCAATTCCGGCAATTTGCCGATTTACCGAAAATT +TCAATTCGGCAATTTGTGAATTTTCCAGAAAATTTCAATTCCGGCAATTT +GCCGATTTGCCTGGAAAATTTCAATTCCGGCAATTTGCCGATTTACCGGA +AATCTCAATCCGGCAATTTGCGAATTTTCCAGAAAATTTCAATTCCGGCA +ATTTGCCGATTTACAGGAAATTTCAATTAAGGCAATTTGCCGCTTTACCG +GAAATTTCAATCCGGCAATTTGTGAATTTTCCAGAAAATTTCAATTCCGG +CAATTTGCCGATTTGCCTGGAAAATTTCAATTCCGGCAATTTGCCGATTT +GCCTGGAAAATTTAAATTCCGGCAATTTGCCGATTTGCCGAAAAATTGCA +ATTCTGGTACATTGCCGATTTCCCAGAAAATTTCAATTCCGGCAATTTGC +CGCTTTACCGGAAATTTAAATTCCAACAATTCTGGCACATTGCCGATTTG +CCAGAAAATTTCAATTCTGGCAATTTGCCGCTTTACCGGAAATTTAAATT +CCGGCCATTTGCCGATTTGCCAGAAAATTTCAATTCTGGCAATTTGCCGC +TTTACCGGAAATTTAAATTTCGGCAATTTGCCGATTTGCCGAAAATTTAA +ATTCCTAAGAAACAGTGGCCGAGATCAGTTTTGACGTCACTTCTCTTCCA +GAAAATGCACTAAAGTGATGTGACGTCATGACTGAGTTTCTAGGCCACGT +TTCGTTTGATAAAATTGGCGGAGGACCTAATTTCCAATGGAAAATAAATT +CAATTTTTTTAAATTTCATAATTTTCTGAAAAACTCACTCCTGAAAAGCA +TCACTCTCTTCCGAAATATCATCATCAAGCCCATCCTGCGTAGACTTATC +ACTATCCGAATCATCATCCGAAAGAGCAAAAGCCGCCAGAGAGCTCGGAT +CACTCAAGTCGAACTTTGTAAGATTCACAGCATGAACCTTCCGAACTCTA +AACGGTGACTTCTTAACGTTCAAGGCTCCATTGCCCTTTGGAATCTCGCC +GACTCGCTTGCGAACCGATGCTCCGCGATACGCAGACTGCAGAGCTATCA +CCGATTCTCTTATCGATAAATATTTCTGTCGTTGCTTGTACTTCTTCCAA +TTACACTGTATCGTTTGAGCTGCTAAGGCTTTTTTCCGAACTTCGGCTCT +TGCAAATGATCCTCGAATCAATGCTTGGATCTTGATAATACCCTCTTTCA +TTCTCAAATATCGCTTTCTAGCCAACATTGTCCTGAACCATCGTTGAAGT +GTATCGATTGATTGCATAATTGTCCGATGCAAATGATCATCGAGTATCAA +CTTTTCAGCGTCTCTCATAAAAATCTTATTGGTTCCATATTGAATATTAT +CATTATCAATCGATGCATGGGAATGTATGTACTCTTTCACATCGTCCACA +GTACTATCCCTTCCGTTTCGCAAAAGAATTCGGTATTGCTGGACAAAGCT +TGGATACTCAATTCTCACAGAGTACCCGGCTCTCCGAATTCGAACGGTCT +CGAGCATTCCGGTGTAGCGGAGCTGGCGGAGGATTATGTTGTCGTCGAAG +TGGTTGGCGATCTATAAAATTTTAGGTGAGTGGTTTTTGTCAATAATTTC +TACTTATATTCAGTCATATAAATAAAAACACATATAAGAAAAGTACCAAA +AATTTCGATCACCTAATTTTTTTAATTTTTTCTATACTCTTACTAGTATG +AAAGAGCAGGATACAAAAATAACTCCACAAGTGATAAACCACCTTTAATT +GGATTAGTGTGTATCACTTTGAGTAAGCTAATATTGAAGGTTTAAATGTG +GACTACCTAGCCTAGCAAGAGAGGTCCTGTAAGTAGACTTCAAAAATATA +GATTATCTTATGAACATATGAACTTATAAACAAACGTTGGTCAAAAAGTA +GGTGTTCAAAGATTCCACCAAAGTTTACAAACTCACCTTATCATTATTAC +TCTTAATACACCTTATAAAATACGGCGTCGCGTTGGCCAGTGTGCTCATC +AACCTCGTCAACGAGTACTCGAACTGCTTTGAAACCGACGATGGCTTCTT +GGCAAGCCTCCGTCCTCCGATAGCCTCCTTCAGAATTTGCAGCGATTTCA +GCAAGCTCATTTTGTCGTCAGACTTTCCCGCCGGGGTACGCCGTGCTTGA +TTTCTAATCGTGTTGAACATGCTGGTATCACAAAAGTCTGGAACTTCACA +GCGAAGTTCGCCACGTAGAAATGCGGAGAGAGCAGAGTCCGAGCCACGAC +GGGGAGACGTTACGATGGAGTCCATTACTCGGAGATGGCCGGCGGATTCT +GGAAATGTTGAATAATTATATTAAGGGCAGGATAGCTCAGTCGGTAGTGG +TGGCCGCTAGCAATCTGGAGGTCACGAGTTCAAGTCCGCCTTCAACCCCT +AGGTTCACCAAGCCTCTATTGGAAAATGGAGCAATCCACGACTGGATTAT +AAGCCACAGCCTTCGGCTAGGACGTGGCTTAAATTGTAGCCCAGTGGGAG +CACCACCAGGTAGTGTACCTGACTCCCAGATCCGCAGATACACTCAAAAT +AAAAAAACTGCGTGGCGTGTACTGCAGAAAACCTAATATTTAGGCCCCGC +CTTTTTCTCGTCCACTCACGGAGAAAAGGCAACAATTTTGAACCCAACCA +ATATCAGGCCGCCGACATCTCACGGGTTCCGCGCGCCGCTGCGTTTAACT +CGCTGTGGGCGTGGCGAGCTGTCTCCGCTTGCTGCGAGTTAAACATTGCG +GCGCGCGGAACCCGTGAGATGTCGGCGGCCTGATATTGGTTGTGGTCAAA +ATTTTTTGCCTTTTTTCCGTGAGTGGACGAGAAAAAGGCGGTGCCTAAAT +ATTAGGTTTTCTGCAGTACACGCCACGCAGTTTTATTATTTTGAGTGTAC +TTGAAGAACGGATCGTCCTTTAATCCTTTAATTATACATTGCATTTTTTT +TCCACTTCTACGACTTCGAAGGGGCGCATTTACGCGCGATGGTCCCGCCA +CCCACCCCAAAAATCAATGGGTGGCGCGTGCCGAGACCATCGCTCGTAAA +TGCGCCCTCCTTTAAAGTCGTAGAAGTGGAAAAAATGCACTGTAGAAATG +AAGAATACCATACTTTTTGTGTTAATTTTTTCTATAATATCGTAGTTGTC +CATTTATTTAAATCTTCCCACTTATTTAACTAAGGACTTCTAACGCTTAT +TCCAGTTATTGGTTCCGATTAAATCTACGAAAACTTGCCACTTTTCTGCA +GTTTCCTTGTCGATTGCTTGAACGCGTTCATCGCCCGAAACACACTTCTC +AGCACATTCCACCTGTGCACCGCCACCGGATCGATTCCCAGCAGGGTCTT +CATCACTGAGCTCGTACTGGACTTCAGAGCGTTCAACACATCCTGTCTCA +TTAGGTCCTTATTCTTTTCTCGGAAACCCTGAAATTTAGTTTTGACGTGA +TGATGGAAGACGTTTTTTTTGGAAGTTGTGTGTTTACCGTAATTTGATAC +TTGACTTTTCCAGCATAATGAGCCACGATGAATGCCGGCTCCTTCTTCTG +TGGGGTCTCATAGTATTCGTTGTTCTGGAAATTTAATCATGGAACTAGTC +ATGTAAAAACATTTGAAGGAGTTAAGGTATGTCCCGGAGGAGTGAACATC +TTAAGCCTGACCTAGAAGTTGATCCAAGTGGCAAGCCGACTGGCCTGAAT +CCTATTAACAGGCCTACATGTGAATATTAAAGGTGGATTAGCGCCAGTGG +GAATTTTGTCTAAATACACTTATAACGATGCCAAACGATCGAATATCATA +ATAAAACACTCCAAAAACTTTTAGATTTTTCATAATTTCCGGTCAAAGTT +TTGGAACATTGACAAAATTTTGACAAATTTGAGCTTTTGAGGACATCAAA +ATCAATGTAACATTTTTTTGGACCCCTACAATGTCTTTTTACGAAAAATT +AAAACAAAATTATAGTATAACAAATAGAGAAAAAAATTTTTTTTAGTCGA +ATTTGTGTCACTTTTTGACTGTAAATAAAAAAATTTTGAAAAATTTTTGA +AAAGTTTTATCATGAGATTTGGTCATTTTGGGAGCATAGGAGTGGTTTTT +AACAATTTCCACCACCGGCGCTACTCCACCTTTAATCGATAATCGATTGC +AATTTTTTCATACCTTCAAAAACTGATTTAACTTCGCCAGCATTGAGTCA +TCTGTTCCATTATTGATATTACTCTCCTCATCGACTAGCCTGAGAATTCC +ATATGGTTTACTCTGAAAATTCATCGGAATTTATATATATGGATATATAT +ATATATATATATATATATATATATATATATGTATATATATACATGTATAT +ATATATATATATACAGTGTGGGAAAGTTCTATAGGACCCCCCCTAATTTG +AAGGTTTGAGGAACTTCCGAAAATTTTTTTGAAAAACTGCTAATGCCATT +CGTTTTTAAATTGAAAAAAACCTATATACATTTTTTTCCAGAAGTTTATC +TCAAAAACTGAGGTCGCGCTGGAAAAAACGTCAAAATCCAGTGTGAAACT +TCTATAGGACCCCCCGTTTTTTTTCACGATTTTTACTAAAATCAACAGAT +TTTGGAATTTTTGACAAAGCTCAAATCAAGTTTGAGTTAGAAATGAGTTC +AGATAAGCAGTTTTGACTTTAAAAAATTAATACGAAATGTTCTCGTGGGA +TCTCCAGACTGGTTCTGATTCTTCCGAACTTTGATGTTCAAGTCTGTTTC +AAGCTTCCTGGTGCTCTCGGTAATGCCAAAACTTGATAAACTCTCTTTAA +CAAGTTCCTACTAAAATTCCTAGCACACACACCATAAAAATTTTTACGCC +ATCCCCAAGAAACCAGTCAGAAACAGCGTATTAACAAGTTGCAGTTATTT +TTGATCAACAACAGAACATTCATATACTAAAATCAAGAAAGGATCAATAG +TTAATCGGGTTTCCTTGTGTGCGGATGATCTCAAACAGTCTGTCCTCCAT +TGATCTGACCAAACTTTTCAGCTGGTTGTCCGGAATAGACTTCCAAGCGT +CGAGAATTCCTTGCTTCAACGATGCAACTGTTGGGTAAGTCTTGTTCTGA +GCATACACGATACGGACAAGAATCCCCCACAAATTTTCGATTGGATTGAG +ATCAGGACTTCGAGCTGGCCAATCAAGAAGGTTGATCTTCTTGAGCTTGA +AATAGTCGCGGGTTGAGTTGCTCACATGGATTGTCGCATTATCCTGCTGA +AATCTAAAGTCTTTTCTGGAGTAGTGACGAAGATATTTGGAGAGCTCCAG +TTCCAAGACGTTCTGATAGTCAGTGCTGTTCATCTTGCTACTGACGAACT +GTATCTCAAGCTTCTTCTTCTCCGTGAACGCTCCCCAAACCATCACCGTT +CCTCCTCCAAAATTACGTCTCGAAAAAACCATTGGTTCCTTGCGCAAATC +GCGCCAATAGTAGCGGCAACCGTCAGGCCCATCGAGATTGAATTTCTTTT +CATCGGAGAAGACAACCTAAAACAATGATCCTAATTATTCACTCTTGCTT +TTTTAAATTCTCACTTTACTCCAATTCGTTCCCATATTGTTCTTAGCAAA +TTCCAATCGCTTGAGTTTATGGTCTGCAGAGAGTAACGGAGCAGGGCGAA +GTTTCTGACGAACGATTACACCAGATCGTTTGATGACATTGAGGATGGTC +CTTTTTGAAGCAGACAATTGAAGCTCATTGCGAATATCTCTTGCCGTCTT +ACAGGAGTTGGAGGCAGCACGAATCACATTTCGTTCGTCACGCACGGAGA +GAGCTTTGCGACGAGGAGCTCTTTTAGATGTACCGTAGCTCACCGGATCC +TTCAGATACTCGCGAATACAGTGTCGAGAACGGGAAATTTTCCTACTCAT +TTCATGCAGGGACACATTGAGCAATTTCATAACATCCAGCTGAGCGCGTT +CAGTGTCCGAAAGGGCAGATCCTCGAGGCATTGCAAGTTAGACTGCTTTC +GAAGTAAGCTTTCCAGCCTCTATATGTGTGCCACAACACATGCCACAATT +CCACATTTAATAATTCACGCAAAAAATAGTAAATAACATCTGTGAGGGAC +AATTTAACTTGAAATATTGGTCCCATGGAACCTTGTAATCAAAGAAAAAC +GATTTGATTCCTGATAAGCCTTCCATTGTTTCCTGCTGCATATTTTGCCA +AATCAGCTTGACTACACAGTCGAAACATCTAAAGTGCGTGCTAGGAATTT +TAGTAGGAACTTGTTAAAGAGAGTTTATCAAGTTTTGGCATTACCGAGAG +CACCAGGAAGCTTGAAACAGACTTGAACATCAAAGATCGGAAGAATCAGA +ACCAGTCTGGAGATCCCACGAGAACATTTCGTATTAATTTTTTAAAGTCA +AAACTGCTTATCTGAACTCATTTCTAACTCAAACTTGATTTGAGCTTTGT +CAAAAATTCCAAAATCTGTTGATTTTAGTAAAAATCGTGAAAAAAAACGG +GGGGTCCTATAGAAGTTTCACACTGGATTTTGACGTTTTTTCCAGCGCGA +CCTCAGTTTTTGAGATAAACTTCTGGAAAAAAATGTATATAGGTTTTTTT +CAATTTAAAAACGAATGGCATTAGCAGTTTTTCAAAAAAATTTTCGGAAG +TTCCTCAAACCTTCAAATTAGGGGGGGTCCTATAGAACTTTCCCACACTG +TATATATATATATATATATATATATATATATATATATACATTTGAAACCC +AAAAAGGACTTATTGGACTTACCTGAAACAGCTGCACACACTCCGTATTA +TCAGTATACTCGATATTGGTCCAAGAAATGCCCTCCTTCAAGTACTCCTC +TTGTTCAAATTGGAAAATATGTTGATTGAAATAGGACTGAAGTTTCTCAT +TGGCATAGTTGATACATAACTGTTCAAAGCTGTTGCATTGAGACCCAACG +TCTTCAAATCCGAATATATCCAAGATACCTGAAAATTACTTCAATTTTTA +ACAATTGATAATTAATCTAACCTATATAATATCCCTTCCCAGCTGAGAAG +TCCTTCTTCAGCAATGCCTGATTAATCCTGAGGACTATATAGTGAAACAA +AGAGTTGTATATGCACTTTGCCATGGCATCTCGGGTGTTGGTGGCCTGAA +ATTAATTTTTTTATCTTAAATTCTTAATTTCACTTCTGTATATATATATA +TATTACCTCAGAGACACTATATCGCAAAACTACAGTTTCTGTCTTCATAA +CATGTCGTTTCATAGTGAGAGCCTGCATGAGAGTGTCGGTTTTGATGTGA +AGCAGATTTGCGACTAAATCCACGACTTCTTCATTTTCAATATACCCACT +TTCATCGCTATGGTAGCCATGTCTCTGGAAAATTATAGGAAAAATAAAAA +AAATTTGATGATGTTATTATATTAGGAATCCTCTAAACAAGGGTTTTCAG +GTTTTTTGGTTTTACGATTATTCAAATTTTTATGGAAATTATTATAATTC +AAATAATTTTCGTCACTATTATAGCCATGTTGTTGAAATAATATGCTATT +TTTAAAGGTGGAGCACCGAAATCTGGAAACTATTTTTAAATGAGTCCAAA +TTTTCCCCTGATTCCGAATATCTATGCGAAAAAATTTTAAAAAATTCATT +TATCAAATTTTTCAAATTTTTCAAACGCCGAATTTTCGCGCCAGAAACGC +CGTGTGCACGTGGTATCAGAGTGTCTCATTTTGGCTTGATCTACGCAGAT +CTACAAAAAATGCGGGAGAAGAGACGCAGAGTTCTCAACTGAGTTCGCAT +GGTTAAAAATGTGCTGACATCACATTTTTTTGGCATTTTTTGTAGATCAA +ACCGTATTGGGAGAGCCTGGCACCACGTGAGTAGGCAGGCATTTTTTGCC +TGACTGCTTGCGGGTGCCTCGTTTTTTCCTCAGAATTTTTTGGCGCGAAA +TTCAAATTTTCAAATAATTTTGAATATTTTCGAGTGAAGCTTTAAAAAAT +TGTTTGTGCCAAATTTGAGTTTGCAAATAAATTATCAAAAAATGTGCTGA +CGTCACGTTTTTGAGCAAAAAAATCCCGCATTGTTTGTAGATCAAACCGT +AATAGGACAGCCTGGCACCACGTGCGTGTGTCGATTTACGAGATTTGTGT +ATATTTACGAAATTTTTTATCTTTATCAGACTCTGATTTCCGTTTCTCAA +CGAGTTTTCTTCATTTTTGTATGTGATTTTTTTAAGGTCCATTAAATATT +TTATCATCAAAACCCTAGCAAAATTTTTGGTTTTCAGTCGGTAAAATCAT +ATAGGTAATTGGATTTTCCGTCAAGTTGTGACCTAATAGTAAGCATTGGA +AATTTTGCCAGTTTTAAATAATTAATTGACCCTAAAACACACATTTCAAA +AAAAAACCGATAAAAATTAAAAATTCCGTAAATATACACAAATCTCGTAA +ATCGACACATGGCTCTAGCGCGAAAATTCAAAAACTCTTGGGTGTACAAA +TAGCGATTTCAAGCTCAAATATAAAATCGTGGAAATTTTTTAAAAATTTT +TTTCACATAGGTATTCGGAGTCAGGGGAAATTTGGAGTCAATTAAAAATA +TTTTCCGGATTTCGGTGCTCCGTAGAACTCTCTGAATAAAATTTTAAAAC +TATGGCAATAGGCAATTATTCGGTAGTTAACTTCTGAGTTGTATTTCTTT +TTGAATCTAAACCGTCCCAATCATTTACCTTGATATATGTGATATTGCCA +AGAAGCAACACTGCCGAAATAATCCCGAAGATGGTCTGCTGGGTCTTTGC +ACAAAATCCGACGGAGCTCATTGCATGCCTCAACCTATCAAACTCATTCC +GCTCGTTCACACCTTCCAGTGCAAATGGCTCGTTCTGGAAATTTTTAATT +TTTTTTTAATTTTTTAAAAAATCGCTTTGAGGTCAGCGAATGTATCCCAT +ATTCGCTCCAAACTTTTCCCAGCTCACCTGATTCAAATACTTATAATCAT +GTGGCTTCAACAAGAAATATTTCTTCCTTTCTTCCTCGTCTGCACCCTCC +AGAAGGTAGTAGAATACGTGGTAGTTTCTGAAAAAAATATTAAAGTCCAA +GTGAGACACCAAGGGAGTTTATGTACCGTTCTCCTTTAGTTTGAAATATG +ATGCGTGATTTTTCCAGCAGGTAGATCTCCACGTTTGCTCTGAAAAGTAC +AAGTATAAGGCATTTTTTGTGGTATAGACATCAGGAGAAGGCTTCAAATT +TTACGTTCAGGTCAATTTAGGTCATAGTGCCTAGTAAGTATGGTACCTAT +AAGCTTGATTACTGCCAAAGTAAAAATTTTCCAATTCCGGCAATTTGCCG +ATTTGCCAGGCATTCCAATTCCGGCAATTTGCCGATTTGCCAGGCATTCC +AATTCCGGCAATTTGCCGGTTTGCCGGATTGCCGGAAATTTAAATTCCGG +CAATTTGCCAAATTTTTTTTCATTTTCGGCAATATACTGGATTGCCAAAA +TGTTACGGCAACTTGCCAATTTGCAGGAACTTTTCATTTTCGGCAAATTG +CCGGTTTGCCGATATCCCAGAAATTTTCAGGTCCGGCAAGTTGTTGATTT +GCCGATTTTCCCCGGAAATTTCAGTTCCGGCAACTTGCCGATTTGCCGGA +AATTTTCAAATCCGGCAATCGCGGGAAATTTCAATTCCGTCAAATTACCA +ACATGCCGGATATTCCAATTCCGGCAATTTGCCAATTTGCCGAGCATTTA +AATTCCGGCAATTTGCCGAATTGCTGAAAATATCAATTCTGTCAAATTGG +CAATTCGCCGGACATTCCATATCCGACAATTTGCCGATTTGCCGATTTCC +CAGAAGTTTTCAATTCCGTCAAATTTCTAATTTGCCGGAAATTTCAATTT +TACTAAGTCGCCTGCTAGCCTCCTAATCTCACCCGGAAACCATTCCATTC +TCCCGATAGTTGATTTTGATGAATTTTCCAAATCTGCTACTATTATTGTT +CGTTAATGTGACAGCATTTCCAAAAGCCTCTAGAACAGGACCAGCTGACA +GAAGTGTCTGCTCAGTACTGCAGCCTGTTGAACCTTTCTGTGATAGCGAT +ATCAAATGGGACATCAGATGATTCGTGGATTCCGTTTTTCCCGAACCACT +TTCCCCGGAGATTACCACGCATTGATTTTCCTTGATACGGAGCATGCTGA +AAAAATTGTTTTTTTAAAAATTAGTAGTGACATTTAGTTAATCCAGCATC +AGAATGTATATCTCTGAAATTTTTTTTTTTTGAAATCAAAAGTGCTTTGA +GGGTCTTGAAACGAACACATAACTGCAAAAAAATTGGTGGCCGAGTTTAT +AATCGGCCACTTGGCAAATATACAAGCCAATACACAAAGTGAGCACCTAC +GTGGCCGAGTGAAGAGAAAACTCGGCCACCGATTTTTTTTGGTCACTTGA +AATTTCAAAAAATAGTAACTGGGTTCCGGTAAGAACTTAGAACTCACTTG +TGGTAACAGACATCGGCGATTGCAAAAATGTGCGGTGGTAGTGAGCCGAG +CCGCTTACTTTGAAAGTATAGCCTAGCATATTTTGGGTTGTAGATCGGAA +AAAAGCAAAACGGGTTCACGGCTACTAGAATTGGACCGATGTACGTGTAA +ATGTGCCCATTCGCGAATCTTTCCCGCAAATTGTCCAAGAGGGTTTGCTC +CGTGAGCTCTGGCAAGTTACAGAGATCGGCGTACTCGCGGTCCTGAAAAA +TTTTAAGGTTTAAAATTTTTTTAAATATAAAAATATTTAAAGGTGGAGTA +CAGGAAATCTTTTTTAATTACTCCAAATTTTCCACTGATTCCGAATATCT +AAGTAAAAAATTTTGAAAAAATTTCCCTGATTTTGTATTTAAGCTTGAAA +TTACGATTTTCATTTGTGCCCGCACCACTTTTTTCAAATACGCCCAAAGA +AATTCGCATTGGAGCGCGTTTGCATCGTTTGATTTTCGTCGTTTATTTTA +TTTATTTTCCACGGGGTTCTGGCCTTCTTCATTGAATTTTCGCGCTTCAT +TGACAATCGCCTGCCGGACAACACATGGAAAAGTGTCGTGTACTCCACAC +GGACAAATACATCAGTTTTACAACTAAAGACAAGCCGCGACGCGACACGC +AATGCGCCGTAAGTCTACACAAAATCTCTCCGACCCAAAATGGCCTAGTT +CGGCAAACTCTGCCATTTCGATTTATGAGGGAAGCCAGAATTTCGTGATT +TTCGCCGAATTCAATTTTCTTGAACCAGTTTCAATCATTTTTGTCGAGTT +TTTGCTAGTTTTTTTTTTGACAAAAAGGAATGAAACTGGTTAAAAAAACT +GAATTTGGCAAAAAATAAATAAAATCTTTAAATGAAGGAAATCAAAGCGC +GCTCCAATGCGAATTTATTTGGGTGCGCATTTGACAAAAACACGTGGTGT +CAGGCAAGGGTGTCAATGTCCCGTAAAAATTTCGAAAACGGGACAACGGG +AATTCCCGTTCCCGTGAAAATTTTAAAAACGGGAAAACGGGAATTCCCGT +TCCCGTGAAAACTTCAAAAACGGGACAACGGGAATTCCCGTTTTTTTGAA +AACACTCAAAAAACGGGACAAACTGGGCGGTTTAAAAAAAAGAGTGCATA +GTTGGCGTAAATTTTAGTGTATTCGAGGCAAATTATAAAAAAAAACTGCA +TTATAAACATTTTTATCGATTTTTTCAATATTAAACAGATATTTAAAAAG +CCAAAAAATGAGGGAAAATGTCCCGTTCCCGTGAAAATTTTAAAAACGGG +ACAACGGGAATTCCCGTTCCCGTGAAAACACCCCAAAAACGGGACAACGG +GAAAAACGGGAAACGGGAATTGACACCCTTGGTGTCAGGCTGTCTTATTT +CATTTTTATCTACAAAAACAGCGGGAATAGTTTTCCAGAAAAATTCTAAC +GTCTCTTAACCAGGCGAAATAAAATGAGAAGTCTGCGTCTCTTCACCCGC +ATTTTTTGAAAATCAAAAAAAGAGACCGGGCACAAATTAAAATCAGGGAA +AATTTTTTTAATTTTTTCACATCTAAATTCGTAATCGGGGGGCAAATTTG +GAGTGATTTAAAAATATTTCCCAGATTTCGGTACCCCACCTCAAAAAAAA +ATAATTAAAGAATTGCCTTACCTGTGGCTGAACCAAGAATTTCGTAAGAA +AAGCGTCAATCGATGAGGCGACCTCTGCACTTCCAAACCGAGTGCCGCCG +GTTGCCGCCCGATAACCGCGGTGTCGAAAAACAAATCGATTTTTTGGAGT +GGCACTGTCCACCACTACAGGCAGTCTTGACCAGATGGCCTGTACCGCGA +CTGGGTATTCCCCGGGGTCTAGGCGGCGTTCTTTATAGGTTTGACCGTCG +GGGGTGCCCATCATTTCGAAGAGGTCAAAGTCTTGTACCGACTGGCCTTC +TAGTTCTGGAAATTTTGACTTTAGAAAAGAAATCATTTTTTTCCTTTTTT +TTTTAAATTAGCCCGTGGCTTTTTTCAAAATTAAAAGAAAATTTGAAAAA +ACATTGCATTAGAGCGCGTTTGCATTCACTCCATGCAGTCCAATTTTGCT +GGGAGCTTGAGTGTCTCATTCGACTTGATCTACACAGATCTACTAAAAAT +GCGGGAGAATAAAATCCACTGATATTGTATGTTTAAGAATGTGCTGACGT +CACATATTTTTGTGCAAAAAATTCCCGCATTTTTTGTAGATCAAACCATG +ATGGGACAGCCTGGCACCACGTGAGATTGTGTCGACAAATTTTTGTTGAA +GATGTATGGCCAAAAACGGCACATTTAAGTAATTTATCAGTAGAGCGCGT +TTGAAATTTTTTTAAAAATTCTTTTTAAAAAGAGTTCCCACTACCCCAAG +TCCTCCGATTTTTCTAAAAACTAAGAGAAGGGAATCTACGACCCTGAGCC +TTTAAAACCTTACCAGCTCTCCCGGCGAGCACTTTTTCGATGAGCTCCTC +CGTCGTGCACCGCTTATGAACCTCCAAGTGTACCGTATCATTTTCACAGT +CGGGATTGAAGCTGTGCATATAGACGGCTACCGTATGTGTGTGTGCATCG +TCTGTCGCGTTGATTGTGTGAGCACGTCGGGGAAAACATCCCGTCGCTCC +AGCTGATATTGAGTCAAATGACATTTAGTTAATCCAGCATCGGGATGTAT +ACGTCTGTAAAAAAAAATTTTTTTTGAAAGTAAAAGTGCCTGGAGGATCA +TGCAACGAACACAAAAATTTCACAAGACCGCGAAAAAAATTGGTGGCCGA +GTTTTCTCTTTCGCGGTCACTTAGGAAATACTAAAATCGCACGGATTTCT +GGCTTCTCTCATAAATTGAAATGGAAGAGTTTGCCGAACTAGGCCAGTAT +AGCTCGGCCATATCTGGGGTATGTTTACGACTTTCCCACGCGTTGGGCGA +TTGTCAATGGAGCGCGAAAAACTCAATGAGAAAGGCCTGAACCCCGTGAG +ATCGAAATGAAAATTTGCTAAATGGCCGAAAATTGAAAACTCGGCCGCCA +ATTTTTCCACACGGCCACAGGAAAAATCGTAACAAAAATTGAGAGAAATT +TATTAGAAAAAATCTGAAAGTAATTTTTATTGCACCGTGGCCGCAAAATG +TAAAAACACGGCCACCGATTTTTTTAATGTGGGGAAAAAGTTGGTGGCCG +AGTTTTATATTTTGCGGCCACTTAGAAAATATTTAGATCGAAGGGAAATT +TTGTTGAAAATACGTTTAACGAAAACCAGTCAATTTTTGTTACATGACCG +AAAATTGAAAACTCGACCACGGATTTGTTATGCTTTATAAATTTTTGAAA +CTATTATTTTTTGATTCAGAAATTTTTGGAATTGAAAAAAACTCGGCCAC +ATTTTTTTTCTCACGGTCACAATTTTCTTTGTGATCGTAAAAATGGAAGC +TCGGCCATGGTGGCCGAGTTTTTTTCGCTGCCACTGGTAACACGTGGTTG +GGTGAAGAGAAAACTCGACCACCGGTTTTTTTTGGCCACTGAAATTTTTA +AATTTCAAAATATTTTAAATTTTGCTGCAATCTTTCACCACAACCGCGAA +AAAATGAAAACTCGGCCACCAATTTATTTATTTTCACTGGGAGAAAAAAT +ATTGTTAGCCAAGTTTTCTTTTAGGCAACAGAAAATCAAAAAATGAGCGA +TTTTTGTTACGTGGCCGTGAAAAGAGAAAACTCGGCCACCAATTATTTTT +AATTTGAGGCACTGTTGTAAAATCTTATAAAAAAACAGGTTTAGTACATT +GAACTCAAAAATAAGGAAGATTTTTGGAAAAACAAAAATTGCTGGCCGAC +AGCTGGAAAAAACTCGGCCACCAACTTTTTCCGGTCACACAGCAAAATCT +CTCGATTTTCGATGTTTGAATATTGAAATCTGGGTTGGATTTTTTAGTAT +CATTTCATTTCCGGTGGAGAAACGAGGGAGAGAAAAAGAGAAAAAAGATT +TGTAGTGTCCCGGGAAGCTCTCTTTCTCATGTGGGAAGAAAGTGGAAGAA +GCTTCTGCAGCAGCAGCAGCAGTGGTTCACGAAAGAGAGAGAGAGACATG +TTGGACATGAAAATGATGAAAAATAAGAAGATGAAGAAGAGAATTACACA +CTACCACCACAACACAGATTATTTTTATCACGTTTTGAGGGGGCGCTTCA +CACAATTTTCATGGCCTAGAAATTTAAATTTGGTGGCCTAGAAAATACTA +TATTAATTATATTAATTATTCTACGAAATTTCAATAATTTAAACGGGAAA +ATTTATTTTAAAAAAGCCTAGAAGAGGTTTTGAAATTGGTGGACTAGGAA +ATGAAAAATTGTGTTTTTGGAATTTTCTAGGCCATTTGAACTTCCTGACG +TCCACAATTTTCATGACTTCGAAATTTGAATTTGGTGGCCTAGAAAATCA +TAAAAACTAAGAAATCGAGAAAAAAGCATGGATGAAATTTTGAATTTTAT +AGGTCATTTGAAATTTGTGGCCTAAAAAATGAAAAATGATTTTTTTTTTT +TTGAATTTTCTAGGCCACTTGAATTTCCTGACGTCCACAATTTTCATAGC +CTAGAAATTTAAATGTGGTGGCCTAGAAAATAATTAAAACTAAGAAATCG +AGAAGAAAAGCGTGGAAGAAGTTTTGTATTTTCTAGGCCATTTGAATTTG +GTGGCCTAGGAAATGAAAAAAAGATTTTTTAGGAAATTTCTAGGCCACTT +GAAGTTGGTGGCCTAGGAAATTAAAATTTGTGTTTTTGGCATTTTCTAGG +CCATTTGGATTAGGTGGCCTAGGAATTGAAAAGTAGTTGTTTTGGAATTT +TCTAGGCCATTTGAATTTGGTGGCCTAGGAAATGAAAAAATATTTTTTAA +AGGAAATTTCTAGGCCATTGAAGTAGATGGCTTAGGAAATAAAAAAAGGT +TTTTTAAAGGAAATTTCTAGGCCATTGAATTAGGTGGCCTAGGAAATGAA +AAATGATTTTCTTAAAATTTTTTAAGCCACTTGAATTTGACGGCCTAGGA +AATGAAAAATGGTTTTTTGGTAATTTCTAGGCCACTTGAATTTGGTGACC +TGGGAAATGAAAAATGATTTTCTTGGAATTTTTTAGGCCACTTGAATTTG +ACGGCCTAGGAAATGAAAAATAGTTTTTTGGTAATTTCTAGGCCACTTGA +ATTTGGTGGCCTGGGAAATGAAAAATGATTTTCTTGGAATTTTTTAGGCC +ACTTGAATTTGACGGCCTAGGAAATGAAAAACAGTTGTTTTGGAATTTTT +TAGGCCACTTGAATTTGACGGCCTAGGAAATGAAAAATAGTTTTTTGGTA +ATTTCGAGGCCACTTGAATTTGGTGGCCTGGGAAATGAAAAATGATTTTC +TTGGAATTTCTAGGCCATTGAATTAGGTGGCCTAGGAAATGAAAAATGAT +TTTCTTAAAATTTTTTAAGCCACTTGAATTTGACGGCCTAGGAAATGAAA +AATGGTTTTTTGGTAATTTCTAGGCCACTTGAATTTGGTGACCTGGGAAA +TGAAAAATGATTTTCTTGGAATTTTTTAAGCCACTTGAATTTGACGGCCT +AGGAAATGAAAAATAGTTTTTTGGTAATTTCGAGGCCACTTGAATTTGGT +GGCCTGGGAAATGAAAAATGATTTTCTTGGAATTTTTTAGGCCACTTGAA +TTTGACGGCCTAGGAAATGAAAAACAGTTGTTTTGGAATTTTTTAGGCCA +CTTGAATTTGACGGCCTAGGAAATGAAAAATAGTTTTTTGGTAATTTCGA +GGCCACTTGAATTTGGTGGCCTGGGAAATGAAAAATGATTTTCTTGGAAT +TTTTTAGGCCACTTGAATTTGACGGCCTAGGAAATGAAAAATAGTTTTTT +GGTAATTTCGAGGCCACTTGAATTTGGTGGCCTGGGAAATGAAAAATGAT +TTTCTTGGAATTTTTTAGGCCACTTGAATTTGACGGCCTAGGAAATGAAA +AATAGTTTTTTGGTAATTTCGAGGCCACTTGAATTTGGTGGCCTGGGAAA +TGAAAAATGATTTTCTTGGAATTTTTTAGACCACTTGAATTTGACGGCCT +AGGAAATGAAAAATAGTTTTTTGGTAATTTCTAGACCACTTGAATTTGAC +GGCCTAGGAAATGAAAAATAGTTTTTTGGTAATTTCTAGGCCACTTGAAT +TTGACGGCCTAGGAAATGAAAAATAGTTTTTTGGTAATTTCTAGGCCACT +TGAATTTGGTGGCCTGGGAAATGAAAAATGATTTTCTTGGAATTTTTTAG +GCCACTTGAATTTGACGGCCTAGGAAATGAAAAATAGTTGTTTTGGAATT +TTTTAGGCCACTTGAATTTGGTGGCCTAGGAAATGAAAAATGATTTTCTT +GGAATTTTCTAGGCCACTTCAATTTGGTGGTCTGGGAAATGAAAAATGAT +TTTCTTGGAATTTTTTAGGCCGCTTGATTTAAGTGGCCTAAGAAGTTAAA +AATAGTTGTTACGGAATTTTCTAGGACATTTGAACTTGGTGGCCAAGGAA +ATGAAAAACTTTTTTTTTTGGAATTTTCTAGGTTTCTGTAATATTAATTT +ATTCATTTAAAAAATTAAAAAACATTAAATTTTTTTTAAATTTCGTGTTT +CAAAAAAAAAATCAAATTTGCCCAAAACTTCAAAAATAAGCTAAAAAATT +GTAAAACGATACAGAACGGCTAATAAAACTTGAAAATAATAAGCGTGATG +AGTCGGAAAGAGCCGCCGGCTGGGACCTTCTTTTTCTCTTTTTTTCTCCT +CTCCCATCCCGAGCAGGAGCAACACAACGAGAGAGCACAACAAGAAGAAA +AAGCAGATAGATATATAGATATATGTTGTCTTCTCTTCATATTCTTTCTT +TTATCTTTTCATTCGAAACAACACTTGGTTCATTTCTCCCGTTGGACGGG +GGGGGGGGGGGGGTGACGCGGGAGACGAAAAAAAAAAGAAAAATTGGGAT +GGGAGTTGGAGAATGTTTGGAAAAAGATTGATTGATCAATCAATTTGCCA +GCCGAGTCTCGGCTATTTTCGGAAATCGGGGCTATGCAAATGCGCCCTAC +TGATAAAATGGGACGTGTCATTTAAACTCCTTGGTTTTTTAAAAAGAAAC +GCAAAATCGGCAAATTTCCAGTTTGCCGATTTGCCAGAAATTTTCAGGTA +CAGCAATTTTCCGATTTGCCGATTTGGCGGAAATTTCAATTTCGACAAAT +TGCCGGCTTGCCGAAATGCCAAAAATGTCCAGGTCCGGCAATTTGCCAAT +GTTGATTTTTGGCAAGTTGCTGGTTTGCCGGAAGTTTTCATTTTCGGCAA +ATTACCGATTTGCCAAAACGCCAGAAATGCTCAGGTTCTCTAAACCGCTG +GTTTTCCGGAAATTTTTCATTTTCGGCAAATTGCCGGCTTGCCAAAATGC +CGGAATTTTTCAGGTCCGGCAATTTGCTGATTTGCCGGAATTTTTCATTT +TCGACAAATAGCCGGTTTGCCGAAACGCAAGAAATGCTCAGGACCGGCAA +TTTGCCGATTTGCCGGATATTTTCATTTTCGGCAAATTGCCGGTTTGCCG +ATATGCCAGAAATGTTCAGGACCGGCAATTTGCCGAATCGCCGGAATTTT +TTATTTTTGGCAAATTGCCGATTTGCCGAAAGGCCAGAAATGTTGCGGTC +CGGCAATTTGCCGAAATGCCATAAATGTTCAATTTCGGCAATTTGCTGAT +ATGCCGGAGTTATAAATTTCGGCAAATTGCCGGCTGGTCGATATGCCGGA +AATTTTCAGGTCCTGCAATTTGATGATTTGCCGAAAAATTTATTTAAAAA +AAAAATTAATTTTCGCCAGACAGGAAGTCTCTAAAATCTCATTTAATAAG +AAGAAACAAAAGAAACAAATAATGGCCTAACAAGTTTCGAGTTACAGAAA +CCTAGGCCACTTTGAACACCGGCGTGGCCTAGAAACCCAGTTCCACAAAA +ATAAGAAAAAATTAAAACTCGGCCACATAATCTAGGCCAGGAGCATACAA +ACACTCCACGAATATTAAAGACTCTTTCTAGGTTAGTGGCCGTTAACGAT +GGAAAACTCGGCCATCTGCCAATTTTGTTGCTTAAAATTGGAAAAATAAA +GTTTTTTTAACTTCAAAAAAAAAAGATCAAAAAGTGAAAAGCGGGGATTT +TTCTCACACAATTTAATAAATCTGTAGCCGAGTAGCGGAGAGCTCTCGGA +GCTCAACGTGAATTTCTATTTGGACGGTAAACATACTCAGCCACCCCACC +CCAGCCCACCGTTACTGTCTTTTTTTTTCTTTTTTATTATCAACCAGCAC +TTATCACCTTTATCTTTGTGTGATCCCGCGCCGCGCAAGAACGAGAGAGA +GAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA +GAGAGAGAGAGAGAGAGAGAGAGAGAGGGATATTGGTGAGACGCAGACAA +TTAGAGTCACTCGTGGGCTCTTTCACACATGTGATATTGAACGAGAAATT +GCGCACCTAGGCCACAAAAAAAACAGTGTATTCGATTTCATGATAGGGGA +GAAGCTGGCACGGTGCCAAGTTTCAGAAAAAATATGGAATTTTTGCTTGA +AGCATGGTGAATCAGACGTGCTTACGTCACAATTTTTCGGGATAAATATT +CCCGCATTTTTTGTAGATCAAACCGCAATGAGACATCCTGATACCACGTG +AGGTTAATTAAAAGTATTGATCGGGATTTTGAGCGTCAAATATGGTGTAT +TTACCGGCAACCCTGATGCGCCAGATTTGACGCGCAAATCCTTCATTTTA +ATAAAGTTGGGCGTCAAATGTGATGCCTGAATTTTCAATTTTTTGAAATG +TTTTGATTTCGTGAAAAATAACGGCGAATTTCAGAAAATTTATAGAAAAT +TTTCATTTGTTGCGACCAAAAAATCTTAAAAACGACCAAAATTCTCAGGA +AATTCACATTTTTCGCCGAAAAAACCATTTTGCGCGTAAATTCTGATGTA +TTTTGCCGTAGGCTATGTGTGAAAACACTGCCGGTAATACGTCATATTTG +ACGCGCAAACCACAAAAATCCTCGAAATTATTCCGGGTGCACAAAATTCT +GAGAATGCGTACAGCGCAACATATCTGACGCGCAAAATATCTCGAAGTGA +AAAATACAGTAATCCTTTTCAAATGACTACTGTAGCGCTTGTGTCGATTT +ACGGGATCTCGACTTTCGAAATGGATTAAAATATATTATTTATCAATAGA +ATATTACAAAAAGAAGTTAATTTCGTAAATCGAGCCCGTAAATCGACACA +AGTGCTATAGTAGTAATTTTAAGAATTACTGTAGTTTTCGCTACGAGATA +TTTTGCGCGTCAAATATGTTGTGCAGTACGCATTCCCAGAATTTTTCGTT +CCCTTTCACAAAAATCTTCAAACTTGCGCGTAAAATTTGGTGCATTGGTG +CCTGTGAGGGGTTCACCTATACAAGTGGTGCCAGGGGCTGTCCCATTACG +GGTTGATCTACAAAAAATGCGGGATTTTTTTGCCCAAACCATGCGAAATC +AGTTGAGAACTCTGCGTCTCTTCTCCCGCATATTTTGTAGATCAACGTAG +ATCAAACACTCTGACACCACGTGGGCCGATGATGTAAGTGCACCAGATTA +CACGCGCAAAAACTGAAAATCTGAAAAAAAAAAAAGCGAAAACTGTCAAA +TTTGAGCGAGTTTTTTATTCCACGAATCACAAGAAAAATCAATAAAAAAT +CGATAATTAAAAAGTGAGTATCATATTATTCGACAACAGAATTTCCAGTT +TCATCAGTGAGCATTGTAAGTATACGATGAGCCATCGACGGTCCAACACG +TCTCCCGTTCTCTGCCACAAGTTCGCCAATCTCTTGAATAGCGAGCGAGT +AGTCCATTTTCGAGTATTTATCGATTGCGGCAATCGGATCAGGGATTAGT +TCGAGAATTGCACGTCGCTGAGCATCCGACAGCCGATCGATTGTTGTGAG +CATTTTCGACCACCAATCCGTGACGATTTCCGAGCGACTTCCGATCACAA +TTCCCTGGAAAAAAATCATCGGGGTTTCATGCTTTTGATCTATTTGATCT +ACAAAAAATGCGGGAATTTTTTGCCCAAAAATATGTGACATCGTCAGCAC +GTTTTTAACCATGTGAAATCAGTTGAGAACTCTGCGTCTCTTCTCCCGCA +TTTTTTGTAGATCTACGTAGATCAAGCCGAAATGAGACATTCTGAGTCTT +GACACGACAAATTCCCGTTAATTACATACGGATGTGAGCCTTTGTTGGAT +GTGAGAGAGTTTCCAGGTTTTTCTCGAAAGCTTTTCTTAAAATTTCATTT +AAAAAATAATTTTTTAACGAAAAACTACAAAAAATCATCCGAAAAACCTG +GAAAATCGATGAAAAACTCTGTGACAAATACAGTACTGTTTAAAGGCGCA +CGCCAGTTTGTGTTCTGAGAATGCGTATTGCACAACATATTTGACGCGCA +AAATATCTAAACTACAGTAATTCTTCAAATGACTACTGTAGCGCGCTAGT +GTCGATTTACGGGTTCGGCTTTCGACAAATTTCGAAAATCGAGCTCGTAA +ATCGACACAACCGCTACAGTAGTAATTTAAAGAATTACTGTAGTTTAGAT +ATTTTGCGCGTCAAATTTGTTGTGCAGTACGCATTCTCAGAACTTTGCGT +TTTCGTGATTTTTTTTTTCAAATTTTAACTGCAGTAAAAAAATAAAACAA +CATAAATTTCATTTAAAAAAAACGATTTTAGCGCTCTTTAAAGGCGCACA +CCCGTTTGTGTTTTAAAAAAAAAAAATGTCGCGTCGAGACCAGATTTCTG +CAGATTTCGCGCCAAGACCCAACCTTATCCCCCTGATACTGTAATTTGTG +GCCTCCTGCCCCTCCTGCACCACCACCACCGCCCCCATCACTTCCAGCGT +CGAGCTTCTTCTTCTCCTGTCTCGCCAAACTTCTCAAGTACTGAGCAGTG +AATAGTGCCAGCTCGGCGATCGTTTCGATTTGCACAATTTGTGCACGATG +TTGCTCGTAGATTTGCAGCGATAAATTGTGCAATTTCTTCTTTTTCGCAA +TTTCTGCCCTGCCGAATGAGACGATGAGCATTGTGCAGCGGCCACCGTTT +TGAAATCCGGATTTTTGCTGGAAAAATAAAATTTAAATGAGATTTTTTTT +AGGTCTCGCAGCGATTTCTCTGGCTGTTTCAATTACGGTTTGATCTACAA +AAAATGCGGGAATTATAAAAAATGTTTGCCCGGTAAAATGTGACGTCAGC +AAAGTTTCTTAACGCTGCGAAATCAGTTGAGAACTCTGCGTCTTTTCTCC +CGCATTTTTTGTAGATCTACGTAGATCAAGCTGAAATGAGACACACTGTG +TGTGCAAACACTATCCACAATACATCATATTTGACGCGCAAACTCTAATT +TTTTTTTCGCTGCGAGACCTAAAAAATCTCAAACTTTCCAGTGAAAATCC +GGATTTTCTTCATTTTAAAAAAGTTGCGCGTCAAATGTGATGTGCCTGAA +TTTTCGCTTTTTTGAAATTTTTTATTTCGTTAAAAATGACGACGAATTTC +TGAACATTTATAGAAATTTTAAAAATTTTCATTTTTTGGGTTAAAAAAAT +CTTAAAAACAACCATAATTCTCAGGAAACTCAAATTTTTCGCCGAAAAAC +CCATTTTGCGCGTGAAATCTGGTGTATTTTACCGTGCCTAGGCTGTGTGA +GAACACTGCCGGTCATACATTATATTTGACGCGCAAACTGCAAAAATCGT +CGGAATTATTTCGGGAACACAAAATTCTGAAAATGCGTATCGCGCAACAT +ATTTGACGCGCAAAATATCTCGTAGCGAAAACTACAGTAATTATGTAAAT +GACTACTGTAGCGCTTGTGTGTCGATTTAAGGGCTCAATTTTCAAAAAAT +CGAGATCCCGTAAATCGACATAAGTGCTATAGTTGTTATTTAAAGAATTA +CTGTAGTTTTCGCTACGAGATATTTTGCGCGTCAAATATGTTGTGCAATG +CGCATTTTCAGAATTTTGTGTTCCCGGAATAATTCCGACGATTTTTGCAG +TTTGCGCGTCAAATATGATGTATGACCGGCAGTGTTTGCCCACATCGCCT +AAGCACGGTAAAATACACCAGATTTTTCGCGCAAAATGGGATTTTCGGCG +AAAAATTCGAATTTCCTGAGAATTTTGGTCGTTTTTACTATTTTTTAATC +CAAAAAAAAATGAAAATTTTTAAATTTTCTATAAATTTTCTGAAATTCAC +CGTCGTTTTTCACGAAATAAAAAAATTTCAAAAAATTGAAAATTCCGCCA +CATCACATTTGACGCGCAACTTTTTTAAAATGAAGAAAATCCGGATTTTT +CTGGGAAATTTGAGATTTATTTAGGTCTCGCAGTGAAAAAAAAATTAGAG +TTTGCGCGTCAAATATGATGTATGACCGGCAGTGTTTGCCCACATCGCCT +AAGCACGGTAAAATACACCAGATTTTTCGCGCAAAATGGGATTTTCGGCG +AAAAATTCGAATTTCCTGAGAATTTTGGTCGTTTTTACTATTTTTTAATC +CAAAAAAAAATGAAAATTTTTAAATTTTCTATAAATTTTCTGAAATTCAC +CGTCGTTTTTCACGAAATAAAAAAATTGATAAAATACACGATAAAATACA +TCAGATTTTACGCGCAAACTGGCAAAAAAATTGATTTTTTGGCTTTTTCG +GACTAAACATTAGAAAAAAGACTATACTCCAACAATTTTTTTCAGTTTTT +TTTTTGAAATTTTTTTTTTTTCAGTTTAAAATGTTTTCATCGCTTTGTTC +GTTTATTTTTGTCTGTTTATTGTGATTTTGTGCGAAATTAATGTAAAAAT +TTCCATATCCAACACTGTTGTGTGATTAATTCGGATAGATAAAAAATGTT +CAGCATGTTGAGTTTAGTTTTCGTCGTCCAATTTAGCTTTTTTTTGATTT +TCAGTCAAGATTTTCTTTCGCCTTCCGCTTTTTGACTTTTCTATGCAGTA +ATGACCAGTCTTGATTTCTAGCTTTTAGTGTTTGGTTTACCATTCTGCTA +TTACATGAGTCACACCTTATCACTAATATAAATGCAGCATAATTTCAGAG +TGAGCAAGCCGCGAGTATTAAACCAGCGCTGTTTTAAACTGATAATGATT +GCAGTTTCCTTCATTCTCACCGAATATCAATTTTTATTCATTCCAGAGTC +TCTCGAACTATGGAAAAACAACTAAAAGCTATGTCCGTCTCGGACAAACC +TGCTGCCCCAGCTGCCCAAAAGCTTGGTACCGCTCCGCTCGCTGCAAAAA +AGACGAGAAATGAGGAGTGGGGAACCAAGGTCAATATCGATACCAACATT +CGCAAATTGAGTAAGTTTTTATTTTACAATTACCAGTCGTTCGAGCTTAT +ATATCAATATTTTTTAGCGATCAAACCGAATCAGCCAATTTACAAGTACG +CTGTGCAAGTGAACTACGTCTTCCGGAAACCTGATGGAACTGAGGCGACA +ATCGAAATGTCCAAATCAGCCAAAAAGGGAACGGAGCACGACAACGACAA +AACACGCTGCCAGAACGTTTACAATGAGGCGATCAAGCGTTACGATGAGC +TGAAAACCGGAGGACCGTTTTTCTACGATCGTCAAGCCTCTTTGTACACT +CTGACCAAATTGAAGAATGAGGTGAATTCGATTTTTTGCTTAAAGTTTAA +TATTTTGCGTTTCAGAGCATCTCTTTCGTTGTTACTGACAAGATTTGCAA +GCGACAAAACTTCAAAGAGGCACAGTTTGTTCTCAAAAAGGTGGATCAAT +CGTTCCAGTCAACATCGAATGACGTCATCAAGACAACCAACTCGTGCCCA +GCCAATGCCGACAAAACTTTGCTTGAGGCAATGAACATCATTGTCTCGGG +ACCAGCGTTCGAAAAGTATGCCGCTTTCAGAGATAATCAAGCTATTTCAT +CTCGTTTTCAGCAAAAATGTTATCACCGTTGGAGCATGCGTTCATTACCT +CATCGACCCAACTGGAGTCGAGTAAGAAACTTTAAGAAATTATCATATTA +GTATTTAATTGTTTTTTCCAGCGTCGCGTACAAGGAATACCCTGAAGGAC +AACTCTACTCAGGAGTTGGTGTTTCAAAGTCGGTGAAGACATTGGAAGGA +ACGGACAAGAAAGTTCCATCACTCTTCATGACAACTGAAAGTTAGTTTTT +CAGAAAATCTAGATTTTTTTCAAAATGTTATAAAATTGTTAATTTTCAGT +GAAGACAACATTGTTCCATCCGGATTATGCCCCACTTGTGGAACTTTTGC +AAACGTTCAGAGGTTTCAGCACAACTCTCAAAGCGAATTCTCCAGCCGCG +CAGAGAATTGAGAAAGCCTTTGTTGGACTGGATGTTGTCTTGAATTACGG +TGTGCACAAGGGTCTCGGAGAGGATGGTGTCGTTATGAAGATCCGTCGAT +TCCACACGTCAGCTAAGGAGACATGTTTTGAAGTTGAGAAGTCAACTCGT +GAATTCACGAACGTCTTTGACTACTTCAAAAAGAAGTATGGAATCACTTT +GAAGTATCCCGATTTATTCACCATTGAAGCGAAAGGGAAACAAGGAAAAA +TTCATTTCCCTGCGGAAGTTCTCCTTCTCTGTCCGAACCAGACGGTCACG +AATGATCAAATGATCAACAATGAGCAGGCGGACATGATTAAGGTAATTTT +ATATTTTAAAATCTGAATAATATCCCGAATCCTTTTTCAGATGTCAGCCG +CACAACCACATATCAGAAAGACGACAACTGATACTATCGTGAGAAACGTC +GGATTGGCTTCCAACAATATCTATGGCTTCATCAAAGTTGAAGACCCAGT +CAACCTTGAAGGAATGGTTCTTCCAAAACCTAAGATTGCGTTTGCCGGTA +ACCGACTCGCTGATTTGGCAAATCCGAAGTCTAGATTCCCCACCGACTTC +AATCGTGCTGGACAATATTACGATGCCAAGGAATTGACGAAATGGGAACT +GGTCTTTGTTCAAAACGAAGAAGTCCAGTAAGTTTCAGTTTGTAATTTTT +CATTTTATTGACTCAATTTCAGAGGACTTGCTAAGCAGCTCGCCGATGAA +ATGGTGAATAATGGTATGAAATGCAGCAACCCAACGATGAGTTTCATCAT +TAGAGGTGATTTGGAACCAATCTTCAAGAAAGCGAAGGCTGCTGGAACGC +AACTTCTCTTCTTCGTTGTCAAATCTCGTTACAACTATCATCAGCAAATC +AAGGCGTTGGAGCAAAAGTATGACGTGCTCACTCAGGAGATTCGCGCTGA +AACCGCCGAGAAAGTCTTCCGTCAACCACAAACTCGTCTTAACATTATCA +ATAAGACGAACATGAAACTCGGAGGACTGAACTATGCTATTGGGAGTGAA +GCGTTCAACAAGCCAAATAGATTGATCGTTGGATTTGTTACTTCTCAACG +AGTTGGTGGAAATCCAGATGTGAGTCATGTGTTACAGCTGCATAATCATA +TTTCATTTTTTCCAGTATCCAATATCAGTTGGATTTGCTGCAAATATGCT +CAAGCATCATCAAAAGTTTGCTGGTGGATACGTGTATGTTCATCGCGATA +GGGATGTTTTCGGATCCATCATCAAGGATACTCTCTTGACAATCTTCAAA +ACATGCACTGAGCAGCGCGGAAGACCAGATGATATCCTTTTGTATTTCAA +TGGAGTTTCCGAAGGTCAATTCTCAATGATCAACGAGGAATTCAGTGCCC +GAGTGAAGGAGGCGTGCATGGCATTCCAAAAGGAGGGAACCCCGCCATTC +AGACCACACATCACCATCATCGCCTCATCAAAGGCTCACAACGAGCGTCT +GTACAAATCCGACAAGGGACGTATTGTTAATTTGGAGCCGGGTACGGTCG +TGGACCATACCATTGTGAGCAATGTCTACACTGAGTGGTATCATGCCTCA +GCTGTTGCTCGCCAAGGAACTGCAAAGGCTACCAAGTTCACTCTCATCTT +CACCACTAAAGCAGGCCCACAAGCTGAGCCATTGTGGCATCTCGAGCAAT +TGACCAATGATCTTTGCTACGATCATCAGATTGTCTTCCATCCGGTCGGA +CTTCCCGTCCCACTGTACATTGCTGATCGTTACAGTCAACGTGGAGCAAT +GGTTCTTGCCGCCAATCAAGGGTAAGTGACAGTAAAATGTATACGACATC +TCATTTATTATTTTCAGTCCAATCTACAATGAAGGACAAATCGATCTCGC +GGCTACCAACAGTGCATATGGCTACGGAGAGAAGAAGCTCTTCACCACTC +GTTTCAATGCATAATTATCTGTACTCCTCCGTTTCTTTTACTTGGCTGTA +TAATGTTTTATTTCCGTCAACCCAGAATACTTTCGCTATGATTGTATATT +TTTTAGCATTTGGTCATTGTAATTTGTAATTATTGTCGGAATGGATAAAA +TGATTTAAGAATCAAATGCATCGCTTCTTGGACAATTCCTGTTGATAATC +TCATTCTGATATTTTCAAAAGTTGTGGTATTGATTTTAAAAATTAAAATA +TTTGCAGCTGCCGCTGTGACTGGAGAAGTTGATGTTTTATTTCTTCCAAT +TCAGCTGTTTGTACCTGTTTTGTAATGTTATTACTTTCTTTCGAACAAAA +TGTCATTCTTTTTCTGGCAGAAAATTCCGCTTTTTAAAAATTATTTTTAC +AACATTACAGATGGATCCTTCTGTTGTGTCTCGATTGGAGAATGTTGCGA +ATCGAATGGAGAATATATTGCTGAAATATGACTCGAACAAAAAAGGCAAT +TAAATAATTGTTCTCGAAATTATAAATTTCAAAAAAATCGCTTTTTAGAA +ACTCCGGTCGGCGCGACGCCTCAAATCATTAATCTTTATGACGATGCGAT +CTGTGAGAATCTCGTCTCGTTTTATGATTTATCTGCAAAAATTGGAGGAG +ATTTGAATCGCCTTGGATGCATGGTAAGGAAATATATAATATTTAATTCA +AATTTTATCGAAAATTATGTTTCAGACTAAGAATCTATTTTTCACGCTTT +TTTCGATGTTTTTTGTGGATTGCGTGTGGGCGCAAAAAAGCGGACAACGA +CGAGTTCGCGACTCTTGTGAACGATTTGACGACGGAAATTGTTGCATTTT +CCGATTTCAAGGAGAAAAATCGAAAATCCGAATTCTATAATCATATTTGT +GGACTTGAAGCTGCGGTTGGAGGTGAAAATTTGCCCCTGATTCCGAATAT +CTATGTGAAAAACTCTTCATTATTTTATATATTTCAGCTTGAAATCGCTT +GTTCATCCATTACTTTTTTCAAGCACACGCCATATTCTCATTGGAGCGCG +CCGTGTTGTGTCGATTTACGAAATTTTCCAATTTTTTCAATTTCAGTTTT +TAAACGAGTTTTTATTTTTGTGGGCTTTATTTTTGTGGGTTTTGCTTTTT +GGGTTAAAAAAAATCTTAAAAACAATCATAATTCTCAGGAAACTCAAATT +TTTCGCCGAAAAACCTATTTTGCGCGTGAAATCTGGTGTATTTTACCGTG +CCTAGACTATGTGTGAGAACACTGCCGGTCATACATCATATTTGACGCGC +AAACTGCAAAAATCGTCGGAATTATTTCGGGAACACAAAATTCTGAAAAT +GCGTATCGCGCAACATATTTGACGCGCAAAATATCTCGTAGCGAAAACTA +CAGTAATTATGTAAATGACTACTGTAGCGCTTGTGTGTCGATTTAAGGGC +TCAATTTTCAAAAAATCGAGATCCCGTAAATCGACACAAGTGCTATAGTT +GTTATTTGAAGAATTACTGTAGTTTTCGCTACGAGATATTTTGCGCGTCA +AATATGTTGTGCAATGCGCATTTTCAGAATTTTGTGTAAAAATTTTTGTG +TTTAGTGATTTTTGCAGTTTGCGCGTCAAATATGATGTATGACCGGCAGT +GTTTGCCCACATCGCCTAAGCACGGTAAAATACACCAGATTTTTCGCGCA +AAATGGGATTTTCGGCGAAAAATTCGAATTTCCTGAGAATTTTGGTCGTT +TTTACTATTTTTTAATGCAAAAAATGAAAATTTTTAAATTTTCTGAAATT +CACCGTCGTTTTTCACGAAATAAAAAAATTTCAAAAAATTGAAAATTCCG +CCACATCACATTTGACGCTCAACTTTTTTTAAATGAACAAAATCCGGATT +TTTCTGGGAAATTTGAGATTTATTTAGGTCTCGCAGCGAAAAAAAAATTA +GAGTTTGCGCGTCAAATATGATGTATGACCGGCAGTGTTTGCACACACAT +AGCCTAGACACGATAAAATACATCAGATTTTACGCGCAAACTGGCAAAAA +AATTGATTTTTTGGCTTTTTCGGACTAAACATTAGAAAAAAAGACTATAC +TCCAACAATTTTTTTCAGTTTTTTTTTGAAAAATTCCATATTTTCTGAAG +TTCAAATAAATATATATTTTTTTAAAGTTCAAAAAATTCAAATTAGCGCG +TTAAAAACGACGTATTCAGGCATCACATTTGACGCGCAATTTTTTTTTTA +AAGAAGGATTTGCGCGTCAAATCTGGCGAATTAGGTTTGTCGGCGGAATA +CACCGAATTTCACGCGCAAAATTTCAAACCTCAATGATAAAATCGGAGAG +CGTATTCGAGGAAATTACGTCTTTCAACGTCTCCGCCGGAACCACGACAG +CGAACAAGTTTTGTGTTGACTGAAAAAAAAATTAAATTTTTCGACAAAAA +AAATTAAATTTTTCAACGAAAAAAAATTAAATTTTTCAACGAAAAAAATT +AAATTTTTCAACAAAAAAAAATTAAATTTTTCAACAAAAAAAAATTAAAT +TTTTCAACAAAAAAAAATTTAATTTTTCAACAAAAAAAAATTAAATTTTT +CAACGAAAAAAAATTAAATTTTTCAACGAAAAAAATTAAATTTTTCAACA +AAAAAAAATTAAATTTTTCAACAAAAAAAAATTAAATTTTTCAACAAAAA +AAAATTTAATTTTTCAACAAAAAAAAATTAAATTTTCCAACAAAAAAAAA +TTAAATTTTTCAACAAAAAAAAATTAAATTTTTCAACAAAAAAAAATTAA +ATTTTTCAACAAAAAAAATTAAATTTTTCAACAAAAAAAAATTAAAATTT +TCAACGAAAAAAAAATAAATTTTTCATCAAAAAAAAATTCAAATTTCCGC +GGAAAGTGCAAAAAATTTACAGAATATTCAAATCGTTCACTTCTCCCGCT +ATCATCTTCACGCAATTCGACACATTTTCGTCGCCATTCGATGCGGGTTC +CCAGTGATGTATCGATTTTCAGTTGATTATCGATTTTTCGCTCCACGTAC +AGTACACTGAGTTCCGCTTCGAGGCCATCTGAAATTTTTTTTTTAATTTT +TTTAACGATTTTTTTTTCAGAAAATCAATAAATCTATTCAGCTGTTTTTT +TTTAACTTTTACACAATTTTCCGTTTGAAAATGTCAAAAAAATGTGTTTT +TGAGCCACATTTTATTCAAAAAATTTTGAAAAATTCCCTGCATTTTCGCT +GTGGGACCCAAGAAGTGCGTGTGCCTTTAAGAATATTTCAATTTTTTTAA +AACTTAAAACAAAGATTTAAAAAATTCTGCTTTCTAAAAATAAATAATTA +TTTATTTTTTTGTGTATTTGTTTGGAAAAAATCAATATTTATCGATTTTT +GTGAATTTTTTTGAAAAAAATCAATATTTATCGATTTTTGTGAAATTTTT +TGGGAAAAATCAATTATTATCGATTTGTGTGAATTTTTAAGAAAAAAATC +AATAATTATCGATTTTTTGTGATTTTTTCGCAAAAAAATCAATAATAATC +GATTTTTGTAAATTTTTTAATCGAAATTCGGCTTTTTCCGGTAAAAACAT +CAAAATTTCGCAAAATTAATCTGATTTTTTCTGCGAAAAATTTAAATTTC +TCATAAAACTTTCGAAAAATCGAATATTTTAAAAATCAATAATTTCGATT +TTTGGTTAATTTTTTTGGAAAAAATCAATAATTATCGACTTTTTGCGATT +TTTTTTTTGAAAAAAATCAATAATTATCGTTTTTTTTTAATTTATTGGAA +AAAATCAATAATTATCGAATTTCAGTGAAATTTTTGGAAAAATCAATAAT +AATCGTTTTTGTGTGATTTTTTTCGGAAAAAATTAAAAATTATCGTTTTT +TGTGAATTTTTTGAAAAAATTAATAATTATCGACTTTTTTTGAATTTTTT +TTTGGAAAAAATCAATAATCATCGATTTTTTTGTGAATTTCTTGGAAAAA +AATCAATAATTATCGATTTTTCCGATTTTTTCCAAAAAAATCGATAAATC +AATAAATTTTCCTTACGCCACGTGTCAATTACAGTCTTCCCCACGTGGCA +AAACGTGTAGAGCTCGCATTTCGAATTGGTTGCCGCCGAAATTTCGCGTT +CGATTTTTCGAGTTTCCTTGTCTTTCTGAAATTTTTTTTTTCTAAATTTT +CTGAAAAATGTTCTTCTGTAAAACCTCTTTTTCCTCTCTTCTCCGCGCCA +TTTCGCTCTTTTTTTTATCCTTTTCCAGCGTTTTTCTCTCTTTTTCAGCT +TCCCGAGCTCGTTTCGCATTTTCTCGGAGTTCCTGAATAAGTTTTAAATT +TTTAAGGGGAAATTTGCTATTTGGAGAGTAAATATTTTCGCTGTGAGACC +CGTGGACCTGAAAATTTTGATTTTCCGCTTAAAATCAACTGAATTTCGCT +TAATTGTGATGTTTTAAGCTGAAAAAGCTGAATTTTGATTTTAAAAAATT +GAAAAAAATTAATATTTTTAAAGGCGCATTTATTGATTTTTTTTCCAAAA +AAAATTTACAAAAAAATTGATAATTATTGATTTTTTCCAAAAAAATTAAC +AAAAATCGATAATTTTTTTTCCAAAAAATTCACTGAAAAATCGATGATTA +TTGATTTTTCCAAAAAAAATTCACTGAAAAATCGATAATTATTGATTTTT +CCAAAAAAAAAAATCACAAAAGTCGATAATTACTGATTTTTTCCAAGAAA +ATTTTAAAAAAAAACGACAATTATTGATTTTTTCCGAAAAAATTACAAAA +AAATCGACAAGTACTGATTTTTTCTGAAAAAATTACAAAAAATCGATAAT +TATTGATATTTTACAAAAAATCGATAATTATTGATTTTTTACAAAAAATT +CACAAAAAAATCGATAATTTTTAATTTTTTTCAAAAAAAAAATCACAAAA +AATCGATAATTATTGATTTTTACCAAAAAAAATCACAAAAATCGATAAAT +ATTGATTTTTTCCAAAAAAATTAACAAAAATCGATAATTATTGATTTTCC +CAGAAAAAATTCACTGAAAAATCGATAATTATTGATTTTTTCCGAAAAAA +TTCACAAAAAAATTGATAATTTTTTAATTTAAAAAAAAATCACAAAAAAT +CGATAATTATTGATATTTTACAAAAAAAAATTACAAAAAATCGATAATTA +TTGATTTTTTACAAAAAATTCACAAAAAATCGATAATTTTTAATTTTTTT +CAAAAAAAAAATCACAAAAATCGATAATTATTGATTTTTTCCAAAAAAAA +TCACAAAAATCGATAATTATTGATTTTTAGGCGGAAAAGCCGAATTTTTA +TCAATTTTTCAAAAAAACAATCGATAGTTTTAAAGGCGCATGCGCTCTCC +TGGGTCTCACAGCGAAAAGTGGATTTTTCAAATTTTTTGGATAAAATTTC +GCTGAAAAACGTATTTTTTTGACAGTTTTAAAGGGAAAATTGTCTAAAAT +CAAAAAAAAATTGTTTTTTCAACAATTTTTTCAGTTTTCGTAAAAATTTC +AGTTTTTTTTTCGCGAGAAAAAAACCAATTCTCGATTGAAAAATCAGAAA +AAATATTTTGGTATAAAAATATTTTTGGTATTACGATATTTTGGGTCCCA +CCTCGAAAATTTAGAGGATTTTTCAAATTTTTAAGATTTTCTTCAACTTT +TAACAATTTTTTTCGGAATAAAAATCGATTTTCGCTGCGAGACCCAAAAA +AAATAGATTTTCTCGAATTTTGCGATGGAACTTTTGATTTTTCGGTGAAA +TTTTCCAAAAAAATCGCAAAATGTATCAAAAAATCAATACTTTCTGCGTC +TCCTTCTCATCGTCGGTTAGTTTCCGTTTTTCGGGTCTCGCCACGACATT +TATGTCAGTATTCTCTTGTGAGCTTGAGCACAACGAGTATGAGCTCGTCT +GATTCTGACGGATCATTTCGTCAAGATTGAGCATTCCCTCATCCAGCCAT +GTTTTTGCCGCAGCTGGAATTGCATCCTTATTCACTGCGTCGACGATGGA +AAAGCTCGCGGAGTACCTGGAAATTATCGATTTTTTATTGATTTTTTATC +GGTTTTTATCGATTTTTTTGATGGGGAAAAATCGGAAAAATCGATAAATT +TCGATTGGAAAATTCAAAAAACTTCGGGTCTCACAACGAAAATTGATTTT +TTTTCTTGGATTTTCAAATTTTTAAACTTTTGTTGTAACAACAGTGGAAA +TTTTTCGAAAAAAAATCAATAATTATCGATTTTTTGAAAAAAGGCAATAA +TTTTCGATTTTTTGAAAAAAAAAATCAATAATTATCGATTTTTTGTGAAT +TTTTGAAAAAAATCAATAATTTTCGATTTTTTGTGATTTTTTTTCGAAAA +AATCAAAAATTATCGATTTTTTGTGGATTTTTTGAAAAAAATCAATAATT +ATCGATTTTTTGTGGATTTTTTGTAAAAAATCAATAGTTTTCGATTTTTT +TTGGAAAAAATCAATAATTATCGATTTTTTGTGGATTTTTTGAAAAAAAT +CAATAATTATCGATTTTTTTTTGAATTTTTTGAAAAAAATCAATAATTTT +CGATTTTTTGTGATTTTTTTTCGGAAAAATCAAAAATTATCGATTTTTTG +TGAATTTTTTTTTGGAAAAATCAATAATTATCGATTTTTGTGATTTTTTG +TAAAATATCAATAATTATCGATTTTTTGTGATTTTTTTCGGAAAAATCAA +AAATTATCAATTTTTTGTGATTTTTTTTTTGGAAAAATCAATAATTATCG +ATTTTTGTGATTTTTTTTGGAAAAAATCAATAATTATCGATTTTTGTGAA +TTTTTTGTAAAATATCAATAATTATCGATTTTTTTGTAATTTTTTCGGAA +AAAATCAATAATTTTCGATTTTTTGTGAATTGATTTTTTTTGGATTTTCA +AAATTTTAAACTTTTAAAATAAATTTTTCCATAGTTTTTTGTTGAAAAAT +TCCTGAAATTTTGAAATTCAATTAATTTTTTCTTTAAAAAAATCGTTGAA +AAATTAGTTTTTTGGAAAAAAAATCAGCGAAAATAGATTTCGCTGTGAGA +CCCAATTGGGCTCCTCAAAGTCCCTGCGCCTTTAAAATATCGTTTTTTTT +TTGTTAAATTTTCCCGCGAAATTAATCAGATTTTTTCTGCGAAAAAGTGA +AATTTCTCAAAGAAACTTTTGAAAAATCAATTTTTTTAAAAAGAAAACCC +CTAATTTTTCCGTTTTTCCCGCTAAAAAAACATCTAAAAAATTTGAAAAA +TCCACAGAATTATCGCTGTGGGACCCAAAGTGCATGCGCCTTTAAGATTA +TCGATTTTTTTCAAATTTTTCAATCGAAATCAGGTTTTTTTTTTCAGCAA +AAATCATAATTTTGCGAAATTAATCTGATTTTTTGTGCAAAAAATTCAAA +TTTCTCTTTTTTTACGTTTTTTCGCCAAAAAAACCATCTAAAAAATTCGA +AAAATCCAGAGCATTTTCGCTGTGAGACCCAAGTCCGTGTGGCTTTAAAA +ATATCGATTTTTTGTTAAATTTTCCAATCGAAATTTGGCTTTTTTTCCGG +TAAAAAATCATAATTTTGCGAAATTAGTCTGATTTTTTGTGCGAAAAAGC +GAAATTTCTCATAAAACTTTTGAAAAATTGATTTTTTTTTTCTGGAAAAA +CCTATTTTTGTCGTTTTTTCGCTAAAAAACATCTAAAAAATTCGAAAAAT +CCCCAAAATTTTCGCTGTGAGACCCAAGGCTCCTGAAAGTCCCTGCGCCT +TTAAAAATATCGATTTTTTGTTAAATTTTTAATCGAAATTCGGCTTTTTC +CGGTAAAAACATCAAAATTTCGCAAAATTAATCTGATTTTTTCTGCGAAA +AATTCAAATTTCTCATAAAACTTTCGAAAAATCGATTATTTTCCGCTAAA +AAATCATCTAAAAACTCGAAAAATCCAGACAACTTTCGCTGCGAGACCCA +AGTCCATGCGCCTTTAAAAATATCGATTTTCTGTGAAATTTCTCACAATT +TCTCCAAATTTCCCGCCGTCACATTCGTCGTTTCCTCAATCATAATACAG +TCCTCATCATCATCATCATCCGAGAGGACTACAATCGCCTCGTCCATCTG +AATAGTGGGAAAATATCGATTTTTTGTAGAAAATCATATATTTAAATTGA +TTTTTTTACAATAAAAAAAATTTTGGGGATTTTTTTGGAAATTTCGGGTA +AATCGTGTAAATCGTGTAATTTAAATTCATTTTTGTTTCAAAAAGTCAGG +GGGGGGGGGGGAAAGAAAAAATTTTTGACAAAGCGTGGAGCGAAAAAAGG +AGTAAATATACAGTCGCGAAAGAACGATCGCTCCGCCAATTTTGCATGCG +GCAAAGGGGCGTGGTTTATTGGGGGCGGGATTCCGGCGCAACCCTGCGGC +ACGCTTTTTTCTCGCTTTTTTCGTGCGGTAATTTTCAGTTATTTTTATTC +GTTTTCTGTTCGAAATTTCACGATTTCGCTCGATTTTGTTCGTTTTTTCG +GATAAAAAAGTGTCCAACTATTTTTTAAATGAAAAATAACCAAGTTTTCA +CAGATTTTACCCGAAAAATGCTTTGTTGGTCTCTCTTTCTGTAAATTACG +ATTGTTAAGAGAGAAAATGGGGGAAAAAAAGGAAAATGTGAAGAGAAAGC +GTTTTTTTAACGTTTTGCTTCGTATATTACAGAAAAAGAGACAAACGAAG +CATTTTTTCAAGTAAAAACTGATAAAACTTGGTTATTTTTCATTTAAAAA +TAGACACTTTTTTATCCGAAAAAACGAACAAAATCGAGCGAAATCGTGAA +ATTTCGAACAGAAAACGAATAAAAATAACTGAAAATTACCGCATGAAAAA +AGCGAGAAAAAAGCGTGCCGCAGGGTTGCGCCGGAATCCCGCCCCCAATA +AACCACGCCCCTTTGCCGCATGCAAAATTGGCGGAGCGATCGTTCTGTCG +CGACAGTATGTAACATGTAAGGTAACAAGGTGGGTTGGTTTTCATGAGAA +AAGGGGGATTTTTTTCCGATTTTTCAGGTGCAGAGCCCACGCTCTCCTCA +AAGCCGAATAATTATTAGAGCGCGCTTGCAGCGACTCGCGTTTCTGCATC +CGCGGTATTTTGACTTTCCACTGAAGAAAGCAGATATTTCAGATTTATCG +AATTTTTAGGTTTAAAATTTTTTTTTTCTGTATTTTTCGAACAAACCTTT +TGTCAAACAGTAAAAATCGAAATTAAAATGACTAAAATGAACTTTTTTTG +TCCACTGGTTGTGAAATGGTTTGAATTTGAAGAAATCAACGGGGTTTTTC +GTATTTTCTGAATATTGTTCTATTAAAAATTGGTTTTAATACATTTTTGA +CTTAACATTAGGGTCAAAAAATGGTTTAAAACCGATTTTTAATAGAAAAA +TATTCAGAAAATACGAAAAATCCCGCTGATTTCTTCAAATTCGAACCATT +TCGCAACCAGTGGACGAAAAAAGTTCATTTTAGTCATTTTAATTTCGATT +TTTACTGTTTAACAAAAGGTTTGTTCGAAAAAAACAGAAAAAAAAATTTA +AAAGCTAAAAATTCGATAAATCTAAAAAAGCTGCTCATTTCAGTGGAAAG +GCAAAATACCGCGGATGCAGAAACGCGAGACGCTGCAAGCGCGCTCTAAT +AATTATTCGGCTTTGAGGAGAGCGTGGTGCAGAGCCCCAATTTTAAACAA +AAAATAGCGGAAAAAAATATTTAAAAAAACGAGGATTAAATAAAAATTAA +ATAATGTCAGCAATGTTCATTGGCATCTCGTCGATTTGTGTCGAGTAGTA +CTGCTCAATGTCGCGGAGAATTCGTACGTCGTCCTGTTTGACGAAATTGA +TGGCGACTCCCTTGCGGCCGAAACGTCCCGAACGGCCGATACGATGGATG +TAGAGCTCACGGTTGTTCGGCAAATCGTAGTTGATTACCTGGAAAATTTT +TTGATGAAAAGCTGATTTTTGCGATTTTCGCCATTTTTTGACCTAAAAAA +TTGGCGAAATTCGGAATTTTTAAACAAATTTTGACGTAAAGTAGGTTAAA +ATTCCAAAATTTTACGGTAAATAGCCTGAAATGCTTTAAATTGATCCTTT +TTTGCACAATTTTAACAATGAAAACCTGTATTTTTCGCTACTTTTAGTTG +AAAAAAGCTTCCAAAACGAGTAAAATTGGCAAATTTTATCGATTTTCGCA +AATTTTTCACCTAAAAATTGAAGAAATCGGTATTTTTAAACAAATTTTGG +CATAAAGTAGGTTAAAATACCAAAATTTTACGGTTTTTAGCAATTTTTGA +GTCAATTTTCAAAATGTTCCAGTATTTTTGCAACTATTTGGTTTTTATTC +ATCTATGTTCTTTGAAAATTCTTTTTTTTAAGGTGAATTAGGTTAGAAAG +GGGTCGATTTTGCAGAATTTTGACAGATTTCGCATGAAAATTTGAATTTT +CAGGCGAAAATCATCAAAAATATGATTTTTTGCTACTTTTAGTTGAAAAA +AGTGTACAAAACGAGTAAAATTGACAAATTTTTATCGATTTTCGCCATTT +TTTCACCTAAAATTTAATTTTTTTTTTCTAGTGAAATAAGTTAAATTCAG +TGTTAAAATGTATCTATTTTCGCTCAAAATTTGAAAATTTTCAATTTTTC +ACTGAAATCCATGAGAAACCAGTGAAAAAATTTTTTCAATTTGAAAATTT +GCAGTGAATTTTATTTTTTCTGCTAATTTTTCGGTGAAAAATGCACTTTT +TCACGAGAATTAGCGGGATTTTTGTATTTTCAAAGTTTTTAGGTCAATTT +TCAAAATGTTTCTCGCTGAAAATTGATTTTTTGTCAATTTTTCACATATT +TTCTATGAAAAATTCCACCTTTTTGCAGAATTTTGACTAAGAAATACGAT +TGTCGCCTAAAAGTTTGAATTTTTCAATTTTTTTTTGCTGAAAATCATCA +AAAATACGATTTTCAACAGAAAATGATGAAATTTTCGCTATTTTTCGCGG +AAAATCATTGATAACCTGATTTTTTCGCTACTTTTAGTTGAAAATAGTTT +ACAAAACGAGTGAAATTGGCAAATTTTATCGATTTTCGCAAGTTTTTAAC +CTAAAATTTAGTTTTTTTCTAGTAAAGTAGGGAAATTCAGTGAGATTTTT +TAATTTTTCACTGAAATCCATGAGAAATTAGTGAAAAAAAAATGTTTTTG +GCCAACTTTTCACATATTTGATATGAAAAATGCCGTTCTGAACAAAAAAA +GCTGTGGAAATTCAACTTATTGTCAATTTTCCGCTGAAAAATTCATTTTT +TTTTCTCAAGAATTCGCATTAAAACTGCGGAATTTCTTGTATTTTCAGCA +GAAAATGATGAAATTTTCGCTATTCTTCGCGGAAAATCATTGAAAACCTG +ATTTTTTCGCTACTTATAGTTTAAAATAGTTTACAAAACGAGTGAAATTG +GCAAATTTTATCGATTTTCGCAAGTTTTTAACCTAAAATTTAGTTTTTTT +TTCTAGTAAAGTAGGGAAATTCAGTGTCAAAATTTACTTATTGGGTAAAT +GGAAATTGTGAATTTCCATTGTAAAAATTTCTGCTGGGAAATTCATTTTT +CCCAAATTTTTCATATAATTAGGCTGAAAAATGCAATTTTTCACAAGAAT +TCGCATTAAAACAGCGGGATTTTTTTTGTATTTTCAACGGAAAATGCTAT +TTTTTGCGGAAAATCACTGCAACTTTTTCCTCACGAGGGCCAAGGAAAAG +TGGTTTCTAGGCCATGGCCGAGGGGCCGACAAGTTTCAGCGGCCATTTAT +CTTGCTTTGTTTTTCGCCTGTTTTCTTTCGTTTTTCACAGCTTTTTCCCG +TTTTTTCTTATTAAAACTGATAAATAAATATTTTTTGCAGATGCTAAAAC +AATTTCCAAGTAAAAAAAATTATGTATTCAGTCGGCAAGCAGCGGTGAAA +GTGGGCAATGTAAAATGATGGATTACGGGAATACAAAACCTGAAATTTTT +CTGAAACATGATACATATGCTGCTTAGATGCTGATACTACCTGATTTTCA +TAACGAGACCGCTGAAAAGTTTTGAGGTTTCCACAATTCAACTTTTTTGG +TGAAAAAATCGAGATTTTCGCACAAAAAGTTGAATTTTGAAAACCTCAAA +ACTTTTTCAGCGGTCTTGATATGAAAATCAGGTAATTTCAGCATCGAAGC +ATCATATGTATCATGTTTCAGAAAAAGTTTAGGTTTTGTATTCCCGTAAT +CCATCATATTGCATTGACCACTTTCACCGCTGCTTGCCGACTGAATACAT +AATTTTTTTACTTGGAAATTGTTTTAGCATCTGCAAAAAATATTTATTTA +TCAGTTTTAATGAGAAAAAACGGGAAAAAGCTGTGAAAAACGAAAGAAAA +CAGGCGGAAAACAAAGCAAGATAAATGGCCGCTGAAACTTGTCGGCCCCT +CGGCCATGGCCTAGAAACCACTTTTCCTCGTCCCTTGTGAGGAAAAAGTT +GCAGTGGGAAAATGCTATTTTTCGCGGAAAATCGAAAATGTACCAAGGAC +ACTTGCGGAACATCAAGTCCTCTCGCCCAAACATCAGTAGAAATGAGGAC +ACGAGTGGTTCCAGCTCTAAACTCCTTCATAACCTCATCACGATCCTTCT +GCTCCATATCTCCATGCATCGATGAGACGGTAAAGTTGGCCTCCTTCATC +TTATCAGTCAACCAGTCCACCTTTCTACGTGTATTACAGAACAACACCGC +CTGAGTGATGGTTAAGGTGTCGTAGAGATCGATAAGCGTGTCGAACTTCC +ACTCCTCCCGATCAACTGCGACGAAGAACTGCTTGATGCCTTCCAGTGTC +AACTCGTCACGCTTCACAAGGATCCGAATCGGATCCGTCATGAATTTACT +CGTCATCTCCAGAATCTCATGAGGAAGCGTCGCGGAGAGCAGCACCACCT +GGGCTCCGGGCGGTAGATAGCGATAGATATCGTAAAGCTGCTCCTTGAAC +CCCTTGTTGAGCATCTCGTCGGCTTCATCGAGCACGAGAAGCTTGATGGC +GCGGGTGCGCAGGTTTCGACGGCGAATCATGTCGAAAACGCGTCCCGGAG +TACCGGAAACCACGTGCTGGCCGTAGTCGAGCTTTCGGATGTCCTCGCCG +AGATTGGTGCCTCCGATACAGGCGTGGCACTGGACATTCATATAGTCGCC +GAGCGCCAGCACGACTTTTTGAATTTGAACTGCCAGCTCTCGTGTCGGCG +AGAGAATCAGAGCTTGGGTCTCGCGGACCTGGGTGTCTAGCGATTGGAGT +ACGGAGATCGAGAATGTCGCCGTTTTTCCTGTTCCGGATTGAGCTTGAGC +GATGACGTCACGAGCCTTGAGAATTGCGGGGATGGCGCGTTGCTGGATGG +CAGATGGCTTTTCGAAGCCGTACGCGTAGATTCCACGAAGCAAGTCTTCT +CTGGAAATCGAAAAAAATTTTGAATTTAGTTTTATATTTAAAGGTGGTGT +AGTCGAATTATTTATTTCTTTATTAGACTCAAAATTGTCTGAAAAAAAAG +TGTACAAAACGAGTAAAATTGGCGACTTTTATCAATTTTCGCCATTTTTC +ATCTAAAAAAATCGACGAAATTCGGAATTTTAAACAAATTTTGACGTAAA +GTAGGTTAAAATTCCAAAATTTTACGGTTTTTAACAATTTTTCCACCTTA +AAGTTGGTGTAGTCGAATTATTTTTTTCTTTATTAGACTCAAAATTGTCT +GAAAACACCGAATTTCATAATGAAACTTCTTGAAAACTGAAAACTTTTCA +AAAAAAAGTTAAGGCCTCTTGAAAAAAGGCCTAAAATTAGTGAAAATTTG +AAATTTGACCAACTTGTCTGTCAAGCGGCTGGAAACAATTTTCTTTGAAA +TTGTCGTCTAATTTTGGGTATACAGGTCGATTACCTTGCGTTTTCAGCTT +TATTTAGGTATTTAAAAGTCGATGGACGAAGAGATTTGTCAAATTTTTTT +CACCAACTATCTTCGTCCATCGACTTTTAATACCTTAATAAAGCTGAAAA +CGCAAGATACGACCTGTATACCCAAAATTAGACGACAATTTCAAAAAAAA +TTGTTTCCAGCCGCTTGACAGACAAGTTGGTCAAATTTCAAATTTTCACT +AATTATAGGCCATTTTTCGAGCCGCCATAACTTTTTTTTGAAAATTTTTC +AAGAAGTTTCATTATGAAATTCGGTGTTTTCAGACAATTTTGAGTCTAAA +AAAGCAATAAAAAAAATTCGACTACACCAACTTTAAGGTGGAAAATTTTT +TAAAAACCGTAAAATTCTGGAATTTTAACCTACTTTACGTCAAAATTTGT +TTAAAATTCCGAATTTCGTCAATATTTTAGATGAAAAAATGGCGAAAATC +GATAAAATTTGCCAATTTTACTCGTTTTGTACACTTTTTTCAACTAAAAG +TAGCGAAAAATCATGTTTTTGATGATTTTCAGCTGAAAATTCAAATTTCA +GGCAAAATTCTGCAAAAAAAGGGTAATTTTTCAGAGAAAATATGGGAAGA +ATTGAAAAAAAAAACTGTTTTCAGCAAGAAAAATGTTTGAAAATTTACCT +TTAAATTTTTAAAAACCGTAAAATTTTGGAATTTTAACCTACTTTACGTC +AAAATTTGTTTAAAATTCCGAATTCCGTCGATTTTTTTAGATGGAAAAAT +GGCGAAAATCGATAAAAGTCGCCAATTTTACTCGTTTTGTACACTTTTTT +CAACTAAAAGTAGCAAAAAAATAATGTTTTGAGGCGAAAATTTGTTTTCA +GCGACAAAATTCTGCAGAAAAAGTTCAATTTGAAGCTTTTCTGGTTATTT +ATAGAGAATTTTCCGTTAAAATCGATAATTCAATACCTCAAGCCCATTTT +GTCAAAAGTTGGGATAATTGAGACCTCCTCAGACGACTCGAACTCCACAG +TCGCCATATCGTCGTTTTTCTTTTTATTTTCCGCCATTTTTGAAGGAAGA +ACTCTGTAAAATCGATAAAAATGAATATTTTCGAGCATTTTTGCAGAGAA +ATTCAGCATTTTTAGGTGGAAATTATCAAAATCAATGAATTTACATCGAA +AAAATCAAGAAAAACGTGTAAAAACGATAAAATTGATTATTTTCGGGCAT +TTTGCAGAGAAATTCAAGATTTTTAGGAGGAAATTAACAAAATAAGTGAA +TTTACATCGAAAAAATTAAGAAAAACCTGTAAAATCGATAAAAAACTAGT +AAAAGAGCAAGATTTCGAATGTTTTCGAAAATACCCTGTTTTTCGAGCAT +TTTTGCAGAGAAATTCAGCATTTTCAGGTGGAAATTTACAAAATAAACGA +ATTTACATCGAAAAAATCAAGAAAAATGGTGATTTATCGGCTATTTTCGC +TCATAATTCGTAGGATTCGATTCGAAACTAAAATTCGAAATTCGAAAAAC +ATGGCCGTGGCCTAGCGTTCCCCTCCTAGTCCACGGCCGCGCACGATTTA +CGGAGAGCACGATTATTGATCGATGACACATGGTTTCCGACTGTTTTTCC +TGTTAAATTTACCCTTAAATCACAATTTTCCATAGAAAATGGGTGGAATT +TTCTCGAAAAAAGAGAAATCACCAAAATCGGCGCCGGTTTCCGATCAGGA +TAATGCGATTTTGGTTTGTTTAATGAGGTTTTTCACATGGAAATTATTAT +TTTTTTGGTAATTCCAGGCGCTCAAAACACAACGGGACAAAATGAAGCAA +ATGATCAAGCGAAAAGAGAATTGTTTGGAGAAGGAACGACAATTGGCAAA +GCAGCTTATAAAGGATGGCCGGAAAGAGTAAGAAATTTCAGAAAATTCAG +TTTTTTTTATTAAAAAAAAAAAATATATATATAAATTTTTAACTAATTTC +AGCCGTGCTTTACTGCTTCTGAAGAAGAAACGCTACCAAGAGAAGATTAT +CGATCAAACCTTGAACCATCTTAGCAAAATCGAGCAAATGGTATTGAAAA +ATCAGAAAAAAATAAAAATTTTCCAGCAAAAAAATCAATAAATTTCCAGG +TAAATGACCTAGAATTCGCAGAAGTTCAACAGCGAGTAACCGATGGCCTT +CGACAGGGAAATGAAGCGCTGAAAAAGATGAATCAACTATTCGATATCGA +TGAAATCGACAGGATTATGGAAGAAACCAAAGAGGCGGCGGAATATCAGG +AAGAAATCTCGAATATGCTGTCCGGCCAGCTTTCCAACACGGATGTCTCG +GACGTTGAGAAGGAATTGGAGGATCTGTTGGCGGCGGAATGGGGCACAGT +TCAACTTCCAGAGGCTCCGAGCCATGAGCTGCCTGAAGCAGAGCGGGAAC +GGCAAAAAGGTTGAGATTTGCCGAGAAAATTCCTAAATTTTCCCTAAATA +AATAATTTTTTTTCAGAAAAAGAGAAGCCACGTCGCGAGAAGATTGCTCT +GGAAGCCTAAATATTGCTTGTTACTGTGAATAAAATAAATTCATTATATT +ATTATATTTTTTATACAATTTTGTCTTACTGGCGTTGTTCTGAACGAAAA +ATTCGTTTAAATAACGCTGTAACAAAAAATCTCATTTTGCGCGTAAAATA +AAATGCCAGTGACGCAATCACCACGACGAAAAATCGCACAGTTTTGGAAA +ATTGCGGTTTTTCAAACTTTTTTTCGCTTTTTTCGGATGCTATTCAAGCG +GCTATAGACTGTTCAAATAGAGATAGAACGGTCAGAAAATGAGAGACATA +GACAAATAAAGAGACAATTTATTGACTTTTTAGGCTATTCTTTGTTGGAA +ACCAACAAATTTTGTGTTCCCAGGCTTTTCTTTGCAAATTCTGAAGGGTT +CTTCTTTGCAGATGCGTCGACGTGTAGCTCTGGACAATGACGAGCATGAT +GGTAAGTTAAAAAATTGGAAAAAAAAACTTTGGTTTCTATTAAATTTTAT +TATACTTATTCCCTTTTTATAATTAAAGGCGTCTAGCTCATTCAAGCTCA +TTCACGACGTTAGTTGACGCATTCCTCCTTGCACGCATGGCCTAGTGGGT +TAAGGCGCTGAACATCACTCAGAAGTCCACAAGTTCAAACCCAACGAGGC +TCCCCCGCTTTTCTAACCCTAGCTTGAGCAATCAAATCGGAACGCGTCGG +AGCTGTCTCGGAGCCAGAAGCCTCATCAAATATTTTGATTGCTTCCAAAC +AATCTATCGCACGTTTGTGCTCCTCATTTCCGTAATGACGTGTGCATGCG +TAAGCTTGATCTTTCCAGTTTTCTAGGTGACTCATTAGAGCAATCGAGTG +AGCAACTCGTTCATTCGGTATTTCATGAGCCAATTGCTATGCGGGACGCG +GGGCTTCTGGAAAAAAATTAAACAAATATTTTTCGTTTTTTTTTCCACAT +GTGTGGATCTCAATTTATTTCTTCTTTTTTTGTTTACCTCATTTTATAAA +ATTCTCCTTTTTTTCTCATTAATTTTTCTGTGGCTTTTTCAAAGATCTTT +TTCAGATTTTCATCTATTTGTTTTAATGTGGAGCAAAATTGAAATTTGTC +TGGTAGATACGGTAGCTTTAAAGGCGCATACTAAATTTAAAGTGACAAAA +TAAATATTTAGTTCCATATGGAATTTCAATTTTTGCTGCCAGGCTGTCCC +ATTACGGTTTGATCTACAAAAAATGCGGGATTTTTTTTGGCCCAAATAAT +GTGACGTCAGTGCGTTCTTAACCATGCGAAATCAGATGAGAACTCTGCGT +CTCAACTCCCGCATTTTTTGTAGATCTACGTAGATCAAACCAAAATGGGA +CATTCTGACACCAGGTATTCGCCGCGGAACCAGTTTTATACCGTATTTCG +TATGCGCCTTTAATTCTACCGTACCCGCTTCTGGAAGTTTGGAAGTTTGA +AAAACTATTAAATAGAATTTATTAATTTTTGCATATTACTTTGTGCAGAA +TACCTCTAAAAATATTAAAATCCAGATAAACATGGTTTTTAAAATGTTTT +GCACAAAAAGCGATGATTTCGCTTCGAAGCCACTTTTATAAAACGCCTTG +TGCGCCTTTAATTCCACCGTACTCGCCAAAATTAAACTGAATGAGCGAGT +TTTGAACTAATTTTTACGAAAAAATCACGTTCTGATCGGTTCTGGTCTTC +CTCTAAAATCGGTTCTGGTCTTCCTCTTTGAATTTTCGCGCTCCATTGAC +AATCGCCTGCCGGACTGGGAAAGCCGTGTACTCCACACGGACAAGTACAT +TTAGTTTTACAACTAAAATCGAGCCGCGACGCGACACGCAACGCGCCGTA +AATCTACACCAGATATGACCGAGCCAAAATGGCCTAGTTCGGCAAATTCT +TCCATTTCAATTTATGAGGGAAGCCAGAAATTCGTGTATTTTTACAAAGA +AATGTGAAAAAGAAGCTAAAATTTCAATGAAATAGAGATTTTTCCCGGAA +TCTCACAGTTTCGCAAAATACTATGGATTAAAAAACGCTGAAACCCAAAT +TTGCGCGTAAAATTCAATGTATAGCGAACATTCACGGATTTCTGGCTTTT +CTCATATATTGAGATGGAAGAGTTTGCCGAACTAGGCCATATCTGGGGTA +GATTTACGGCGCGTTGCGTGTCGCGTCACGGCTCGATTTTAGTTGTGAAA +CTAAATGCATTTGTCCGTGTGGAGTACACGCGTTGTCCGGCGGGCGATTG +TCAATGGAGCGCGAAAAATTCAATATGGAAGGCCAGCACCCCGTGTTAAC +ATTTAAAAATTACAAGATTTGCCCCCTCAAACATCCCTGGAAAAACTAGA +AAAACCTCGTGTGCTTGCCTGACAACAGCTGTTCACCGACAAAAAGATGA +CGGGGAGGGCTTCAACAGAGCTTGTGTTTCCTCGTCAACTCTTTCGAGAA +CTGACAGCACTTTTCATATAACTCATCACTAACTTTCGCTGCTCGTGGCG +GTTTTTTTTAGTTCCCCAGTAATGAGTCAATTTTGTCTGTTGCTCAGAAC +TCTCAATTACCGATGCTATTAGCGGAAGGACTTTTGGAGCGCCGGAGCCA +GAGCAAAATTCATTTTTATTTGAAAAATGAGTGATGAGTTTTTCTCTCTG +TTTTTCCATGTTTTTCTCGTTATTAGGCTGTAACTTTCCACATACACTTG +GTGTCAGAGAGTCCCATCACGGTTTGATCTACAATAAAAGTGTGACGTCA +GCACGTTCTTAACCTTGTGACAATAGTTGAAAAATCTGCGTCTCGTTTCC +CGCATTTTTGTAGATCACACCGTGATGGGACTCTCTAACACCACGTACAC +ATGAAAATTTCGCTGAGAACAAATTTTTGCGCGTCAAATCTGATGTATCC +GGACTGTACCGATATCAATACATCGAATTTGACGCGCAAACTCCGTTTTC +ATGGGGAATTGTTGAAAAAATTGTTTAACTTCCGGAAAATTAACATTTTT +CAGAGAAAATCAAAATTTTTCTGTTTTTCCTTAAATTTCTAGGAAAATTG +TAGCAGATTTTGTTGAAAAAATTCAAATTTCCACTGAAAAAAGTGAAAAA +AGAAGACGATGTGTAAGCCTAAGCCTAAGCCTAAGACTAGGTCTAAGCCT +AAGCCTGAGCCTATGCCTCAGCCTGAGAATAAGCGTGAGCCTAAGCGTGA +GCCTAAGTCTAAACCTAAGCCTAAGCCTAAGCCTGATCCCAAGCCCACAT +GGTGCCAGGCTGACCCATAACGGTTTGATCTACAAAAAATGCGCGAAATT +TTTTGCCCAAAAAATTTGACGTCAGCGCTTTCTTAACCATGCGAAATCAG +TTGAGAACTCTGCGTCTCTTCTCCCGCATTTTTTGTAGGTCTACGTAGAT +CAAGCCTAAATGGGACACTCTGACACCACGTGAAGCCTAATCCTGAGTCT +AAGCCTTATCCAATTTCCGAAAAATCAATAAAAATGCAAATAACATAGAT +ATTCCCGCCTAAAGTTCAATAAATTATTTTTTTTTTGAAACTTTTTTCAA +AACTTGCGAATGCATAGTACCAAAAAACGCCATATTTGACACGCAATTTT +TGGATTGACTTTTTTTTGAATTGATATGTCATGAGCATCACTCAAGTGGT +TCCAAAAAGGCGTCAAGTACTTGAGCCCTCCCTGAGCCACCACCGTCTCC +AGAGAGCAGCCGAAACCAAAAACAAATAGGGGGAAAATGAACAGTTCTCT +CTGTTTCAAAATCTATATATTCCTGTTCTTTGTATTATCTTCCGTGCGGC +TTCAGCCCTCTACTGCTGCTCCAATTCTTTTCCATGTTATTTACCGTACC +GATTAGACGAATGAACAGGACCCCCTTTTACCGTTCAACCGATGAGCCAA +TGTGCTCTTTGTTGGCTAATTTGGGTGTTTTGCTCATTTGGAGGAACACT +AACTTCCCTCTCTAACTACACACTACGTGGAAGAGTTTTTTCAGATTTCT +AGGCCTCGCAACTTTCCTTGGTGGCCCAGAAAAACGCTTAAAACTTCAAG +GTCAAAACGTTCATTTTTGTTGAAAAAAATCGGTTTTTACTTGAATTTTT +GTAAGTGGAAGAGTTTCCTAAATTTCTAGGCCATGTGCTTTTTCCTGCTT +ATCTGAAAATTTTGTTCAAATTTTCTTTTTTCACTTAAATATTCCCCGAA +AATCTTGTCCACAAAAAGAAATTTTTGAACATTCAGATCATTTTTTTAGA +ATGGAAGAGTTTTCCAGATTTCTAGGCCACATGGCTTTTCCTGGTGGCCT +AGAAAATTTTCTGTTGGAAGAATCAGGTTTTTACTTGAATTTTCGTAAGT +GGAAGAGTTTTTTACATTTCTAGGCCACGTGATTTTTTCCTGATGGTCTA +GGAAACTTGTTTTCTCTAATTTTCCCCGATTTTGGATAATATTTGTTTAG +TGGAAGAGTTTTCAGAAATTCTAGGCCACGTGGTTTTTTTTGGAAAAGAA +ATATTTAGATCACATTAACATGTACTTTTATCAGATTTTTTGCCAAAATA +CCAATTTTACAAGCTATTTTTTTGTTATATGTAAATTTTGTGGAAGAGTT +TTTAAAATTTCTAGGCCACCTCTAGATGCACGTGGTGTCAGAGTGTCTCA +TTTCGGTTTGATCTACGTGGATCTACAAAAAATGCGGGAGACGAGACGCA +GAGTTCTCACCTGATTTTACATGGTTAAAAACGTGATGACGTCACATTTT +TTGGGCAAAAAATGCCCGCATTTTTTGTAGATCAAACCGTAATGGGACAG +CCTGACACTACGTGTACGTGCAGATGGCCTAGAAATGCTAAAATCTGTTT +TTTAAATGTAACTTTGAAAGTGAAAGAAACAATTAGAAACAAGTTGGCTG +TCGCCCCCAAAAAGTCTGTTCTGGCTATGTGGTCGCGAAAAGAGAAAACT +CGGCCACCAATTTTTTTCCACGGCCAGATCTATGACGCTATGACGTCACA +TTATCAGCTTGTTTCCGATTTACACACACATACACGTACACTTTCTCCGT +ATCACTTTCACTGATAGCTTGAAACGAGATTAATCATCATTCCAGCTATT +CTTTTTTATTTATTAGGTTAATGCCACTACTACTATTATTTTTTCATATT +AAAAATACAATGAACTATGTAGACATAAATTCAAATGAGATGCCAAAAAG +TGAGTTCGAACTTGTGGAAAATGTGTGTTTTTTAATAAATTTTTCAAAAA +TATAGTAAATTTCTGAGAAATTTTGATTTGAATTCCCGCCAAGCATTTTT +TTGAAAATTTTGAATTTCCGCCAACCATTTTTCCTTTTTTTTCAGAAAAT +GTGAAAAAATTTTCTAAGCAAATTTGAATTCCCGCCAAGATTTTTTTTGA +AAAAATTTCGAACTCGCGCTAAAGTATTTTCTAATAGCAGGATTATTGGA +ATCCCCGCCAAAACATATTCTCAGAAAATTTGAATTTCCGCCAAAACTTT +TTCTGATAAAATTTAAATTCCCGCCAACCATTTTTTCCTGAGAAAATTGG +AAGAACATATTTTCAGTGAGAAAATTTGAAAATATTTTTTTCAGAAAGTT +TGAATTCCTGCCAAAACATTTTCTAAGAAAATTTGAATTCCCGGCAAAAC +TTTTTCTGATAATTTTTTGAAATTCCCCGCAAAAATTATAGTAAATGAAG +ATGATTTGAGCAAAGTTATGACGTGGCCGCGGAAAAAATTGATGGCCTAG +TTTTCTCTTTTCGCGGCCACGTAGCCAGAACAGACTTTTGGGACCGTACA +ACCAACAAATATTTCTTCCCCTTTCAAAAATACATAAAAACCAGATTTTG +ACATTTCTAGGCCATCTAGAGGTGCCTCGTGGCCTAGAAATTTGAAAAAC +TCTTCCAGAAAATTTGTTCTGTATTTCTTGAAAGTGCTCCAACAAATCTG +TGCAAATTTTAAAAACGTTTCAAAATATTTATTGAATAAATTCTTTTGTT +GCACAAAGAGGTATCAAATCAGACCACCAGATTCGACCGTTGATCATTGT +TTCAGTTGATAGGTAGGCAGGCGTGGTTGCCTGAAACCTGCCGGCCTCAC +GCTGGGCAAGAGGCAGGCCGCCTTAATGTCAGGCAGGCAATGCCTACATG +CAAGCCCTACTTCTACGATTATCTCGAAATTTAGCGAGTTTTTATTTGTC +CAAAAAAAATCGCAACTGAACAACATGAAAAAGCCGCCAAAAACTTTCAT +AAAATTCTGTCCGTAGTTTGCCGTTTCTTGCGTCTCATGCTTAATCCCTA +CTGTAATTATGCTGAGATTTTCGATCTTTTTCACTTTTTGAAAATTTTTG +GCAATTCTTTTTAAGTTTGTTGAGATTGTAACTTATGACAAACAGTAACT +AAAAAGCGTGGCCGCCAAATTTTCTAGGCCATCAATATCAGTTGCGTCAT +TTCTTCACCATACTGGACCGAGAAATATTCTAGGACATGTGTTTGCGTCA +TTCCTCTTCCATTCCTAGTCCCAAAAATTCCAAGACCACTGGTAAGTTTG +GCCGAGAAATATTCTAGGCCATCGATGTTAATGACGCCATTTCATACCCG +AATTGGCCACTAAAATTCTTAGGTCATCAGTGACGTCACACCTCTTCCAA +GCCTTGGAATGAGCATTTCTAGGCCCTCTAATCTAGGCTTGGCCGTCAAA +TTTCCTAGGCCAGGTGACGCCATCCCTCTTCCATGCTCGACCACTAGGTC +AAATGACGTCACTTCTCTTCCACCTACCGCACTTTGATTTCCTAGGCCAC +CATGTGACGTCACTTCTCTTCCATCTAGGTTTCCCATGCCCTTCTCCTCT +CACGTGGTATCAGAGTGTCTCATTTTGGCTTGAATACGTTGATCTACAAA +AAATGCGGGAGAAGAGACGCAGAGTTCTCAACTGATTTCGCTTGGTTACG +CACGTGCTGCCGTCACATGTTTTTGGGCAAAAAATTCCCGCATATTTTGT +AGATCATACCGTAATGGGGTGTCCTCTTGTTAAATATCGAAATTTCACTC +AAAAATTTTGAACGTTGAGCTTTTTGTCTCTGGTCAATTGGTCAGCCGCG +CAGTGTTCCGGTGTTTGTGCTCATGTTTTCGTGTGCACATTTGTGCTGCT +GCTAAGGCGTATTTTGTTCCGGGCGGGGACAGGGGGGAGAAGCAAAAATG +TGTCAAATTTTGTTTGTTTTGCCATTGATATTGTCCTTCTGCTCAGAGGA +TTTCCTCATTTTACGCCGTATGTGCAAAAGCATAATCACCACAATAATTT +TGAATATAAGTTTGCAAACGCGCCCTATTGATAATCCTCGCCCGTGTAGT +CTGCGTGCACGTGGTGTCAAAGTGTCCCATTTTGGTTTGATCTCCGAGAA +ATGCGGGAGAAGAGGTGCAGACTTTTCAACTGATTTTGCATGGTTAAGAG +TGTGCTGGCGTCACGTTTTTCTGGGGGCAAAAATTCCCGCATTTTTTGTA +GATCAAATTGCAAAGCGCCCTATTGATAATCTTAGCCCGTGTAGTCTCTT +GTTTAATTTTCAATTTTTCTGGTTCGGCACCTAAACTGTAACTACGACAC +TCGGCAAAGTTAGACTGTTAAACTCCGCCCACTTAATGGCACCTTTTTTG +CAGAAATGTACCCAACCGACAAAGAGCAGACACGGACCACATTTGAGACG +AGAAGTCGGCGGAAACGGCTGGCGCAGGTCGCCGCCACAATTGCTAGCGT +GATATTACTCTTGTTGGCAGGTAAGTAAAAAACTACGACACTCCGAGACC +AAGAAAAAAATCGATAATCGAAATATTGAAAATTGCAAAATTTATTTCGC +CGGATCATTTTCCATATCGATTTTCTGAATGGTATGGTGATAGCAATCCT +CATCGTAGGCACATCCCTGGTGAACCACGTACTCTTGACCTGAAAAATAG +GTTTCGTTCGGTGGAGCACATTTGCATACACTGACCTTTAATCGGGTGGC +GACACGCTTTACACTTGAAACATGCCATATGCCAGTGGACATTGAACGCC +GACACGCATCTCTCAAAAGTCGGCAATTTGCACGCGTGGCATTTTGGTGA +CTTGGCCGCCCGGTGACAGTCCGCGCAACGGAGCGCGTTACCGTACGGCG +CGGGCATTGGATAACACGGAGTCATGCCAATGACTGTCTGGAATTTTGGA +GAAATTTATTGATTTTTTGACGGAATTTAATGAAATAAGGAAAAATCAAT +AATCGACATATTTATTTCGCAAAAAAAAAAAAACATTATTGATTTTCACG +GATTTCTGTCTTCCTCATAAATTGAAATGGAAGAGTTTGCCAAACTAGGC +CATTTTGGCTCGGCCATATCTGGGGTAGATTTACGGTGCGTTGCGTGTCG +CGTCGCGGCTCGGTTTTTGTAGTAAAACTAAATGTATTTGTCCGTGCATG +GAATTCTGGCTTCCCTCATAAATCGAAATGGCAGAGTTTGCCGAACTAGG +CCATTTTGGGTCGGAGAGATTTTGTGTAGATTTACGGCGCGTTGCGTGTC +GCGTCGCGGCTCGTTTTCAATTGTAAAACTGCTGTATTTGTCCGTGTGGC +GTACACAACACTTTTCCACGCGCTGTCCGGCAGGCAATTGTCAGTGGAGC +GCAAAAATTTAATTAGGAAGGCCAGAACCCCGTGTCCGTGTGGAGTGCAC +GACTTTCCCGCGCGTTGTCCGGCGGGCGATTGTCAATGGAGCGCGAAAAA +TTCAATGAGGAATGCTTTTTGCAAAAACAAATTACATAGGCTTCTGGCCT +TCCTTATTGCATTTTTCGCGCTCCATTGACAATCGCCTTAAAGCAGGGGA +GTGTGTGTGTGTGTACTCCACACGGACAACTTAAAATGAAAACCGAGCCG +CGACGCGACACGCAACGCGCCGTAAATCTACTCCGGCCGTGGCCGAGTCA +AAATGGCTTAATTCGGCAAATTCTTACATTTCAAAATATGAGGGAAGCCA +GAAACGTGTGTCACATGTTATAAAATTAATTTTGAAAAAAAATTATTAAA +TTTCGCAAAAATAAATTATCGCTTTTTGTAAGAATTTATCGAATGAATTG +ATTAAAAATTTATCGAATTTTAGCGAATCAGAAAATATCGATTTTCACTA +AGAATTTATCGAATTTTTCGATTTTCGCTAAAATTATCGATTATTGCAAT +GTTTTACCTGACAAACCGAGCATTTCAGGCATGAAATATGATACATCTCG +TCTTGAATTTTGATCACTTTTCCCTGCAAAAATCGATATTTTCAATTGAA +TATATTTCCAAAAATGTGCTCACAGTTTGAGCTTCTTGACGAGTCAGCGT +TGTTGTGCAGCCTTTGCAATGGATATTATATGGAAGAACAATCTTTTGGA +GACGTTTATTGTTCGACGAGAACAACATTTTTCGAATTTTTGAAATGATT +AATTTAAAAATTTAAAAAGGAGAAAATTGAAGAGAAACGTGGGAAAACGT +ATTGATTTTTCAAAATTTTATTGATTTTATAATCACGGGGTTCTGGTCTT +CCTCATTGAACTTTTCGCGCTCCATTGACAATCGCCTTCCGGACAACACG +TGGGAAAGTCGTGCACTCCACACGGATAAATACATTTAGTTTTACAACTA +AAATCGAGCCGCGACGCGACACGCAACGCGCCGTAAATTTACCCCAGATA +TGGCCGAGCCAAAATGGCCTAGTTCGGCAAACTCTTCCATATGAGGGAAG +CCATAAATCCGTGTATAATCAAACGCGCAATTTAAAAAAATCGGTAGTTG +AAATTTATCGATTTTCCCTCGATCTTATCGATTTTTTAAAAGACTTATCG +ATTTTTATCCAAATTTATTATTTGAAAAATCAACGTTTATTGATTTTTGT +CATGATTTATCGATTTTCTCAAGAGATTATCGATTTTTGCTGTCGATGCA +CCATGTGCAAACTTCGCCACGTTTTTTCGCGGCGAGACCCAAATTTTTTG +AATTTTCAGTTCTCGGTCTGGTATACGGTAGCTTCTACCTCTACCGTCGA +TATGTGACAGATGCAAATGATAAACGGGATAATGATGAATATTTGCGAAA +ACTCGTTCGTCAAGTCAATGACTCGCCGGAGACCACGTGGAAAGCCAAAT +TCAATAAGTTTGGTGTCAAAAATCGATCTTACGGATTCAAATATACGAGA +AATCAGACGGCGGTCGAGGAATACGTGGAACAAATTCGAAAATTTTTCGA +GTCTGATGCGATGAAGCGGCATTTGGAGTGAGTTAACTCAAATTTGAGCG +GGAAACAACGATGCTCCGCGCTCTCGCCGCATGTAGTTTAGCGCGTAAGC +TGTGATGCATACGATAGTCCTGCAATGCATCATATTTTACACGCAAATGC +AGAAATTACCAAATTTCGAGAAAAATCTATATTTTCCTTTTAAAAATTAT +CGATTTTTTAAACAAAACTTCTGAATAATTGGATTTTTCCAGAAGTTTTA +AAAAGTTTTGGGTACAATTTTAAAAAGACAGCAAAATGTTCGTAAAACAC +CAGGAAAGAATTTTGCGCTTAATATCTGATGCTTCGTAAACTCCACGGGC +TTCCGGCCTTAAAGCCGAGCTACGCGCCGTAAATCTACCCCGGCCGCAAC +GCGCCGTAAATCTACCCCGGCCGTGGCCGAGCTCAAGTGGCCTAGTTCGG +CAAAATCTTCCATTTCAAAATATGAGTGAAGCCAGAGGCGCGTGAATGAT +GACTTCCACACGGTTCGGTAGAGCGCATTTACACTTATGTACCCTTTGCC +GGGCTGCGTTCAAAACCTAAAAATTTGAAATTTTGCGCGTAAGATCTGGT +GCATTGGGTTCTGAATTATTTCGACAAAACATGGTGCATCATCCCAAAAA +TTGCAATTTTGCAGTGAACTTGAGAACTTTAACAGCTCCGATGTTCCGAA +AAACTTCGACGCTCGTCAGAAATGGCCGAATTGCCCGTCAATCTCGAATG +TTCCAAATCAGGGAGGATGCGGGAGTTGCTTCGCGGTCGCCGCCGCCGGT +GTCGCCTCCGACCGTGCCTGTATTCACTCGAATGGAACTTTTAAGTCACT +TTTGTCCGAGGAGGATATTATTGGATGCTGCTCGGTGTGCGGAAATTGTT +ACGGCGGAGATCCACTGAAGGCCTTGACCTATTGGGTTAATCAGGGACTT +GTTACAGGTAAGCGGTGACGTCATAGGTGGCCTAGGAACCTTTGATCTAC +AATGTGATTGAATTTTATATCACGCAATTTGTAATAATTTCTAAAAAAAA +TTATCGATTTTTCTGAAAATTAACTTGTTCCAAATTTTGAACGAATTTTC +TAGAAGATTTTTGCAATTTATCGATTTTTGCAAGCTATCGATTTTTCCCG +CAAACTATCGATTTTTCTAGAAAATTATCGATTTTTCTAGAAAATTATTG +ATTTTTCTAGAAAATTAACGATTTTTCTAGAAAATTTTCGATTTTTCTAA +AAAAAATTATCGACTTTTTTCTCAAAAGTATCGATTTTTGCAATTTATCG +ATTTTTTGAAATTTATCGATTTTCCCTGCAAATTATCGACTTTTTTGAAA +ATAAGCTTTCCCCAAAAATTTGAACGAATTTTCTAGAAATTATCAACTTT +TGCAATTTATCGATTTTTTTTTTGCAATTTATCGATTTTTTGCAAATTAT +CGATTTTTTGCAAATTATCGATTTTTCCAAACAATAACGATTCTTCTAAG +CCCGTGGAAGAGTTTTTCGAAAACCTAGGCCATCTCTATTTCCAGGTGGC +CGTGACGGTTGCCGTCCCTACTCGTTTGACCTGTCGTGTGGAGTCCCGTG +CTCGCCGGCCACGTTCTTTGAGGCCGAGGAGAAGCGAACATGTATGAAGA +GGTGTCAGAATATCTATTACCAGCAGAAATATGAGGAGGATAAACATTTT +GGTTAGAGATATTTTTTTTTAGAAAAATAGAGAAAAATTTCTGGGATCTA +TTCAAAAATGGCAAACTTTTTGGAAATTATCGATTTTTTCCGGTAAATAA +TTATCAATTTTTTTCTCGGAAAATATCGATTTTTTCGGAAATTGACAATT +TTTTCGAAAATTATCGATTTTTTCCGTTAATGATCGATTTATTCGGAAAT +TATTGATTTTTCCGATAATTATCGATTTTTCGGATAATTATCGATTTTTT +CCGATAATTATCGATTTTCCGGTAATTATCGATTTTTTCCGATAATTATC +GATTTTTCGGATAATTATCGATTTTTTCCGATAATTATCGATTTTCCCGA +TAATTATCGATTTTTCCGGTAATTATCGATTTTTTCCGATAATTATCGAT +TTTTCCGATAATAATCGACTTTTCCGATAGTTATCGATTTTTCCGATAAT +TATCGATTTTTTTTCGATAATTATCGACTTTTCGGGTAATTATCGATTTT +CCCGATAATTATCGATTTTTCCGGTAATTATCGATTTTTTCCGATAATTA +TCGATTTTTCCGATAATAATCGACTTTTCCGATAGTTATCGATTTTTCCG +ATAATTATCGATTTTTTTCGATAATTATCGACTTTTCGGGTAATTATCGA +TTTTTTTCCGGAAATCATGAATTTTTCCAATAATTATCAATTTTTTCCGA +TAATTATCAATTTTTCCGATAATTATCGATTTTTCGGATAATTATCGATT +TTTTCCGATAATTATCGATTTTCCCGATAATTATCGATTTTTCCGGTAAT +TATCGATTTTTTCCGATAATTATCGATTTTTCCGATAATAATCGACTTTT +CCGATAGTTATCGATTTTTCCGATAATTATCGATTTTTTTTCGATAATTA +TCGACTTTTCGGGTAATTATCGATTTTCCCGATAATTATCGATTTTTCCG +GTAATTATCGATTTTTTCCGATAATTATCGATTTTTCCGATAATAATCGA +CTTTTCCGATAGTTATCGATTTTTCCGATAATTATCGATTTTTTTCGATA +ATTATCGACTTTTCGGGTAATTATCGATTTTTTCCGATAATTATCGATTT +TTCCGATAATAATCGACTTTTCCGATAGTTATCGATTTTTCCGATAATTA +TCGATTTTTTTTCGATAATTATCGACTTTTCGGGTAATTATCGATTTTCC +CGATAATTATCGATTTTTCCGGTAATTATCGATTTTTTCCGATAATTATC +GATTTTTCCGATAATAATCGACTTTTCCGATAGTTATCGATTTTTCCGAT +AATTATCGATTTTTTTCGATAATTATCGACTTTTCGGGTAATTATCGATT +TTTTTCCGGAAATCATGAATTTTTCCAATAATTATCAATTTTTTCCGATA +ATTATCAATTTTTCCGATAATTATCGATTTTTCGGATAATTATCGATTTT +TTCCGATAATTATCGATTTTCCCGATAATTATCGATTTTTCCGGTAATTA +TCGATTTTTTCCGATAATTATCGATTTTTCCGATAATAATCGACTTTTCC +GATAGTTATCGATTTTTCCGATAATTATCGATTTTTTTTCGATAATTATC +GACTTTTCGGGTAATTATCGATTTTCCCGATAATTATCGATTTTTCCGGT +AATTATCGATTTTTTCCGATAATTATCGATTTTTCCGATAATAATCGACT +TTTCCGATAGTTATCGATTTTTCCGATAATTATCGATTTTTTTCGATAAT +TATCGACTTTTCGGGTAATTATCGATTTTTTTCCGGAAATCATGAATTTT +TCCAATAATTATCAATTTTTTCCGATAATTATCAATTTTTCCGATAATTA +TCGTTTTTCCCGATAATTATCGATTTTTCCGATAATTATCGATTTTTCGG +ATAATTATCGATTTTTCCGATAATTATCGATTTTTCCGATAATTATCGAT +TTTTCCGATATTTTTTTTCGGAAATGGCTGCCCCATCGCGGTTTGATCTA +CAAAAAATGCGGGAATTTTTAGCCCAAAAACATGTGACGTCAGCACGTTC +TTAACCATACGAAATCAGTTGAGAACTCTGCCGCATTTTTTGTAGATCTA +CGTAGATCAAGCCGCAATGAGACACTCTGGCACCAAGTGTCTGTAATTGA +CTTCACGGAAGAAAATATATTTTTATTTAATGCGCAAAACTAAAATTCAA +AATTTCGTTTCGACCAATACACCATATTTTAAGCGCAAATTTCAATTCAA +ATTTTTGCAGCAACCTTTGCCTATTCAATGTATCCCCGCTCAATGACAGT +ATCCCCCGATGGAAAGGAACGAGTAAAGGTGCCAACAATCATCGGTCACT +TCAACGATAAGAAAACCGAGAAGCTGAACGTGACCGAGTACCGTGACATC +ATCAAAAAAGAAATTCTACTTTATGGTCCCACCACGATGGCGTTCCCAGT +TCCCGAAGAATTCCTTCATTATTCGAGCGGAGTGTTCCGCCCGTATCCAA +CTGATGGTTTCGACGATCGAATTGTGTATTGGCACGTGGTTCGATTGATC +GGATGGGGAGAATCAGATGATGGAACACATTATTGGTTGGCTGTTAATAG +TTTTGGTAACCATTGGGGTGATAATGGTGAGTTTTCGTGCAAATTGCGCA +CGGCCCGGCAAATGGTACATCCATACAAATGCGCTCCACTGATAATTTGA +GTTTAGCCAGGTTTGGGCGCGTTTTAAGGAAAACGCCTTGGTCCAAAAAA +TTTAGAATTTGATTTCGGACATTTTTTATATGCATCACAAAAATGTTGGA +CGAGCCGTTTTTGAGAAAAAGCCCAGGTATACGGTAAACAAATTGCGTAC +AGGTGCCACTTCCCGGGCCGTGATGCGCGTTAAATATAGTGCTTTTTAAG +AATGCGTGTTGCGCAACATATTTGACGCGCAAAATATCTCGTAGCGAAAA +CTACAGTAATTTTTCAAATGACTACTGCAGCGTTTATGTCGATTTACGGG +CTCGAAAAAAAAGTTACAGCGATATTCCATTTTTTCTCATTTTTTGCTTA +TTTTTATTTAGTATTCTCACGGTGTGTCATTCTGTCCCATAACGGTTTGA +TCTACAAAAAATGCGGGAATTTTTCGCCCAGAAAAATGTGACGTCAGCAC +GCCCCTAACCATACGAAATTTGTTGAGAAATCTGCGTATAAATTCCCGCA +TTTTTTGTAGATCACGCCGAAGTGAGACACTTTGACACCACGTGTATTCT +ATCTAAAAATAAATTATTTCAAAAATAGAGCCCGAAAAAAAAAATCGACA +AAAGCGCTACAGTAGTCATTTAAAGAATTACTGTAGTTTTCGCTACGAGA +TATATTGATATTTTGCGCGTCAAATATGTTGCGCAGTACGCATTCTTAGA +ATTTTGTGTTGCCGTAAATAAATTTGGACGTCAAATACAGTGCATATTGC +GGTCGATCGGCTACAATATATTTTGCGAGCAAATTTGGAAGTTTTGCGCG +TCAAATATGATGTAGCCGATCGGTCATGTTACAAAACACCATATTTGACG +CGCAAAACTTTAATTTTGGACAAAAAGTCAGAGAATTAGTATTGCGTAAA +AAACTGGCAATTTTTTTCAGAACATTTCTGAAATTTTCAATATATTTTCA +AACTTTTCGCGTCAAATATGGTGCATCAAGTCGCGAACCAAATACACTCT +AACACGTAGTGCCAGGCTGTCCCATTATAGTTTGACCTACAAAAACGCGG +GAATTTTTCGCCCAAAAAAATGTGACGTCAGCACGTTCTTAACCATGCAA +AATCAGTTGAGAACTCTGCGTCTCCTCTTCTCCCGCATTTTTTGTAGATC +AACGTGATTCAGGCCGAAATGTGACACTCTGACACCACGTGGCCCTAATT +AACTCGTAAAAATCACCGTTTTTTTTCCAGGACTCTTCAAAATCAACACA +GATGACATGGAAAAATATGGTCTAGAGTATGAAACAGCAGTCGTCTAATT +ATAATTCGGCAAAAATTTTTTGTAAATAGTTAAATATTGTCCACCTATTT +CATCCCCACCCGATTGCATCTCAACTTGTCCCATTTCCGAGAAAAATCAA +TTATTTATTTTTATTCGGCCATCATTTATTAGCTCCCTCATTCCATAGTT +TTTTTTTAATTAGATTTTTTTTGGATGCTAAAATTTGCCATTCTCATAGA +CATTTTCAATATTTGTGTAAAATAAATCATTTTTCTGGTCTTCAATTGAT +GGAAAAAAACAAAAAAACAATGCGCGTCAGGTTTGGTGTATTGTGTGCAA +ACACCGAGCGCATATTTTGAAATTTATTTTTTTTTCGAATTTATTAAAGT +TGCTGATTTTCTTTAATTTCAGGCTTAAAAATGTCGGATTTTGTGCCAGA +AACCGAGGAAAATGAAGAAGAATCTCAAAAAATCGATGAAATCCATGAAA +TCCCAGCTCAAGCAATTATCATCGACCAAAGTGAGGAAAATGCTGACTTT +ATCAATTTTCAATTACTTTTTGCATTTTTTCTAGGTTTTTCTCGACGATT +TCTCAACAATAAATGGTACGGAAAGTACGGCGAAGATGGGGATCTTCTGG +AGCACATCGACGAGGACTGGGAGCCCGTAGGCCTCGACGAAGTGGAATTT +CTGAGCCAACTGTGGTTTGAGCAGGAGGATCAGGAGAAAAAAGCTCATAG +GCACTATGATTGGGATGAAGAAAAGAAGGAATGGGTGCCGAAGGCCAAGC +AGGAGGAGGTCAATGAGGATTTTATCGCAGAATATCAAGCGAATTACGGG +GTTCAGTATGATGATATTTATAAAAAAATGGACGAAGAATTGCAAGAAAA +AGCGGCAAAAGCTCAAAAAGAAGATGAAGAGAAGAAGGAGAAGAAGCGGA +AGAAAAAAGTTGGCTTGGGAGCCGGGGAAGACGCTAAAGAGGGCTGGCTT +GACCTAGGAGATAAGGTTCATGCGGTTTATGTGTCAAATCTTCCGGAAGA +TATTACAGACGAGGAATTCCAGAAATTTATGTCAAAATGTGGAGTTATTC +AGCCGGATATTCGAACGAATAAGCCGAAATGCAAGCTTTACCGGGAGGAA +AACGGCAAACTCAAAGGCGACGGAAGATGTTGTTATATTAAGAAGGAATC +TGTCGAGCTTGCCTGTAACATTCTCGATGGAGCGAACTTAAACGGGCGGG +AAGTGAAGGTTGAGGAAGCTCGATTTGAGATGAAGGGCGATTTTGATCCG +GCGAGGAAGCGGCGGAAATTGACTGCGGCGCAGAAAAAACGATATATGGA +GCAGCAGAATAAGTAATAAAAAATATTTGGTGAAATTTGAAATAGCTCGT +AAATCGACATTAAGCTGAAAAAATGAAAAAAAACCAAAAAAAATCGTATT +ACGGGAACACAAAATCCTGAGAATGCGTACTGCACAACATTTTTTTTTTT +TTTGACGCGCAAAATATCTCGTAGCGAAAACTAAGACTACTGTAGCACTT +GTGTCGATTTACGGGCTGCTCGATTTTCGAAATGAATTAAAAGAATTTAT +TTATGTGATATTGAAATTGGGCAAAAAATAGGAAAATAATACAAAAAAAT +CTAAAAAATTTATTTCAATAATCGAGCCCCCGTAAATCGACACAAGCGCT +ACAGTAGTCATTTAAAGAGTAGTTTTCGCTACGAGATATTTTGCGCGTCA +AATATGTTGTGCAATACGCATTCTCAGAATATTGTGTTCCCATAATATAT +CGACGAAAAAATTGGCCCAAATCGTGGATTTTTGTCCGAATTTGATGACA +AATGGCTTTGAAAATCACAAAATTTCAGAGAAAAATTTCGATTTTTGGTT +TAAAAAAACAAAAATTGAAACCCAACAAAATTGTTAACTTGAAAACCTGC +TGAAAATCTTAGAATTTTCAGATTTCACCCAAAAAATACCAGATTTAACT +CGAAAATTGCGAATTTTAGGCCAAATTCCTTGCATTTTTCATAGAAAAGA +TAAACTAACGACACAAAATCAAATGAAATTGACTAAAAAACTATTGAATT +TTGTAGAAAAATCCCGATTTTTGCCTAAATTTGCAAAAAAAATATTTTAT +TTTAGCATTTATTTTTCTTAATTTTCACACTAAAAATTACGAAAAAAGAC +AAAAAAAATTTTTTTCATTCAACAATTTTTTGGGCTAAAATGTGTAATTT +TTGCGGGAAGAATTCGAAAAATTATTAAAAATCGTAGAGACTAACTGAAA +ATCAATTTTTTAGGGACCAAAAAGCCAACTTTTGCCGATTTTACTCAAAT +TTTTCCGTGAAAAATCCGGAATTTTTAAATATTATTTAATTGCGAAATTT +TACAATTTTTACACCTAAAATAAGGGTAATATGGTAGCTGGTCTCGACAC +GACAATTTTTTTGTTAAATTCTAAAAAAGGTGTGCGCCTTTAAAGAGTAC +TGTAATTTCAAACTTTATGGAATTTTTTTTTGATTTTTCAAATAAACTAC +GAAAAATCGAAGAAAATTCCACAAAGTTTGAAATTACAGTACTATTTAAA +GGCGCATACCTTCTAGAATTTTACAAAAAATTTGTCGTGTCGTGACCGGC +GACCGTATTACCCTAATTTTTGGTGTAAAAATCGTAAACTGTCCGGATTT +TTCACTACGAAATTCAAATTCGAGGAAAATCGAAAAAAATTGGTTGTTTT +GGTTCCTAAAAAATATATTTTCAGTTATTTTCTACCATTTTTTAATAATT +TCTCGAATTTTTCCCTCAAAAATTACAAATTTCAACCAAAAATTCTGATT +TTTCCTTTCCAGAATCTTCGAATGGACGCCCGATAAGCCACGTAACTACC +GTCCAAAGTCGGACTGTACGGTTATTGTCAAAAATCTGTTCACTCAGGAA +ATGATGAACAAGAATGCGGCGTTGATGTTGGATTTGAAAGAGGAAATGAC +ACAAAGTTGTCAGAAATATGGAATTGTTAAGAAAGTCGTCGTTTATGCGG +TTGGTATTGAGGAAATTTGTGGAAATTTCGATTTTTGTAAAAAAAATTTA +TTCTAAAAAAATAAATTAAAAAAAAAAGATTTAAAAAATTTAAAGCTAAT +TTTCGAAAAATTGAAGCTAATTTTGGAAAAAAAACCGAAAATTTTTTTTT +TTAGAAATGTCGATATTCATAAAAAAATATTCTAAAAACGGGATCAAAAA +TTTTTGAAGCTATTTGTCGGAAAAATTTTTAAAAATGTAAAGCTAATTTT +CGAAAAAAAACCCAAAATTATTGGATTTAACAAATTTTCAAAAAAATTGT +TCTAAAAAAGATAACCTTTAACATTAAAAAAATTATGGCTATTTTTCGAA +AAATTAAAAAAAAACAATTTTTAGCTAATTTTCGAAAAAAAACCGAAAAT +TTGTGGAAATTTCGATTTTCAAAAAAAATTTATTCTAAAAAAAAATAAAT +TTTTAACATTAAAAAATGGCTATTTTTCGAAAAAACCGAAAATTTTTGGA +AATTTCGATTTTCGAAAAAAAAGTATTTTAAAAAAACAATGAGAAATGGT +TATAAATTGTTCTTTCAAAAATTTTTTACAGCTTTTTTTTTCGAGAAATT +TAAAAAAAAAACAATTTTTAGCTAATTTTAAAAAAAGTAAAGCTAATTTT +CAAAAAGAACCCCAAAATTGATGCATTTATCGATTTTTAAAATAAATTGT +TCAAAAAAAGATAAATTTAAAAAAAAAGTTATTGGATTTTTTAAAGTTAT +TGGATTTTTCAATTTTCAAAAAAAAATCATCAAAATGTATAAATAAATAA +AAACTATGGATTTCGAAAAATTAAAAAAAACAATTTTTAGCTAATTTACG +GAATTAAAACAACAAAAAATTTCGGAAAATCGAAAATTGTTGGTTTTTTT +TTTCGATTAAAAAAATTCAAAATCTTCTGAAAGACATTTTTAAAATTTCC +AAAAAAAAATTATGAGTATTTTTCAAAAAACAAATCGAATTTTGATTAAC +TTCCGATTTTTTTGACATTTTTTGAAATTTGAAAATCATTAATTCAAAAA +TTTTTATTGAAATAATTCAAAAATTTTTATTGAAAAAAAACGAAAATTTT +TGATTTTCGCTTGAATATTTCGGAAAAAACAATCGATTAAAAAAAAAATA +GGCTTCTAGTTATTTTTCAAGAATGCTTTTTTTTTGACAAACTGCTGATT +TTTTGTCAGTTTCGTCGATTTTCGTTGTAAAAAATCAAAAATTCAAAATT +TCTTCTATTACGAGTGCACAAAATGCTGAGAATGCGTATTGCACAACATA +TTTGACGCGCAAAATATCTCGTAGTGAAAACTACAGTAATTCTTTAAGTG +TCTACTGTAGCGTTTTCGGAAAAATTCCACTTTTTTTATTTAAAAAAAAA +AACGAAATATTTTGATTTTTTTTTATTAAAAAAAACGAAAAATTTTGATT +TTTTATTAAAAAAAACGAAATATTTTGATTTTTTATTTAAAAATGAAAAA +TTTTGATTTTCCAAAAAAAAAGGCTCCTAATTAAAAAAAAAAAATTTTTT +TGAAAAAGTGCAGATTTTTGTCTTAAAATTTAAATCAAAAATTTTTAAAT +AGACTTTTTCCATCAAATTTCCCCAATTTTCAGAACCACCCGGACGGCGT +CGTATCGGTAACCTTTCCAACGACAGAAGAATCGGATATGGCTGTAAAAT +ATCTTCACGGACGAGTAGTTGACGGTCGGAAATTGACAGCCGAGCTCTGG +GATGGCCGGACAAAGTTTAAGGTCGAGGAGACGGAAGAGGATGAGGAGAA +GCGTCGGAAAGAGTACGAGAAGTATATTGAGGGTGGAAGTAGTGAGACGA +AGGAGGAGAGCGACGACGATGATGACGATGAAGCTGAAGATAATTGATTG +ATCTAAATTTTTTCTGAAAAATTATTTTTAGTTTATACATTTTTCCGAGA +GGAGCAACCGATCAATTTTTACCAAAACTATGTTCAAAATCGCCCAAAAA +TATCAAATTTAGTGAATTTTCGTTTTCATGGATTTTTCGAAAATTAGCTT +TAAAAATGTTTGCCAAATTTTTCGACGATATCGCGATATTTTAAAAATTT +CGAACAAAAATTGCCTAATTTCAATTAAAATCCCTTTTTTCGAAATTTTC +TAATTTTCTGGGCCAATTGGGTCGTTTAAAAAGAAAAATGGCCAAAATTT +GAGAGTTTTAAAAAAATTCTAAAATTTCAATCCTACGATTTTCCGGGAAA +AAAATTTTCTTGGAAAATTGCTTTTTTTTTGAAAAATTATTTTTAGTTTA +TACATTTTTTTTCCGAAAATAGGAACAACCTATCAATTGAAATTTTCAAA +AAAAAATTAATTAAATTTGGAAGCATTTTCCGAAAAATTGCATGTTTTCG +GTTTTCTAGAAAAAAAAAACTAAAAGAACGAAAAATTTCACCAAAAATCA +AATATGAAAATACTTTCCTAAAAATCTGAAAAAACCAGAAATTTTCAATT +TTCCCTATTCAAAAAAATTCAAAAAAAAAACCAAATTTCAGTTAAAATCC +CTTTTTTCGAAAATTTTAAAATTTTCTGCGCCATTGTGTCGTTGATTTGA +AATTTTTTTCTAAAAATCCGTGAATTTTTGAAATTAAACAAAAAATTTGA +AAAATCAAAAATTATCGATTTTTCAACGAAAAAAATTCAAAAATTTCAAT +CTTACGATTTTCCTAACTAAAAAAAAATTTGAAGTAACGAAAATGTTCAA +TTTTTTCGAAAATTTTCGAGGTCATTTAGAGTTTTTTCTGTGAAAATTGC +ATTTTATATACTCATTTAAATTAATTTTTATATATTCCTTTCCCGAAAAC +TTCAAAAAAAAAACCCAGTGATACAATTAAAATCGAGATAATCACAGACA +AAGTAGGCAGTAGGCAGGCAAAAAACAGGCACATATTAAGGTAATACAAA +ATTCTGATAATGCGTACATCGCAACACATTTGACGCGCAAAATATCTCGT +AGCGAAAACTACAGTAATTCGTTAAATGGATACTGTAGCGCGCTAGTGTC +GATTTACGGGAATCTTAAAGAACCTAAAGAATTGTAGGAAAAATGGAGAT +CCCGTAAATCGACACTAGCACGCTACAGTATCCATTTAAAGAATTACTGT +AGTTTTCGCTACGAGATATTTTGCGCGTCAAATATGTTGTTCAATACGCA +ATTTTAAAATTTCGTGGTCTCATAATAATACACAATTAACTAGTAAATCT +ACAAAATCTACAAAATTCTCTTCATCAACTCTTCCACAGCTCGATCGACC +TGTGCATGAGTCTCCTCGTACGCCCACAGAGAGCACAACGCCACGTTGCT +ATTGTCGAGACGTTCCTTATTCGAAATCTGTGACGACATGCGATCCTTGG +CCTGATCTTCAGTCAGGTTATCCCTCGCAACGACTCGACGGACGGCTTCA +TCTGCTGGCACGAAGACGGTCCACGTTTCGGCGAGCGTTTTGTGCCATCC +GGCTTCGATTAGTGCGGCCGCTTCGATGACTGAATGAATTTTTTTTTCAA +CTTTTGCAGAAAAAATTATGATTTTGCAAAATTAACGGGGAAAATTGGCT +GTTTAAAAAATATTTATTATTTTCGCGTTTTTTTAAAATAAAAATCGATG +AAAATTCTGCAAAGTTTGAAGCTTCAGTACCCTTCAAAGGTGCACACGTT +TTAGAATTTAGCAAAAAATTGGCGTGTTCACGATTTTTTGGTTAAATTCA +AGAAAGTGTGCGCCTTTAAGGAGTACTGTAATTTCAAACTTGCTGAATTT +TCATCGATTTTTCACTTTTTTTCCACGATTAGTAAAATTTGTGTTATTGT +AGATTTTTTAAATTTAATACCAAATTTTCCAAAAAATCGAAAAAAAAAAG +AAAAAATGTAATTTCGTTATTTTCAAAAAAATAAATTGAAAAATTGAAAA +AAAATCCAAATATTCGATTATATTTTTTCAGAAAATAAAAATGAAAATTG +GAAAAAAACATATTTTTGGGTTTTTCGATTTTCCAAAAAATTTAAACATT +TAAAAAATCTAAATTTTCGATTTTTTTCAAAAAAAAAAAATTAAAAATCG +CACAAAAACCAAAAAAAAACATTTTTGGCCGATTTTCCAAAAAAAAAAAG +AAAAATAAACAAAAAACAAATATTTCAAAAAAAAAAACAATTTTTTCCGA +TTTTCCAGAAAAACAACTGAAAATCGGAACAATAATTTGTTTTTTCTATT +TTTCAAAAAATATTGAAAAATAAAAGAAAAAACGGAAATTTTCGATTTTT +TTCCGATTTTCCAAAAAAAAAAAATTCAAAATCTCACAAAAACCAAAAAA +AAAATGAAAAATCAAAGAAAAACGAAAATTTCGTTATTTTCAAAAAAATA +TCGAAAAAACTTTTTTTTCTTCCGATTTTTCTGAAAAACACTGAAAATTG +TGGAACAATAATTTTTTTCTATTTTTTTGGTCTCCACGATTTTTCGCGAA +AAATTTCAAAAATTAAAATTTTTTTTTAAATCCAAATTTTCACTTCCCCC +CCCCCCCCCCCCTCACCAACAACTTTCGCCGTCGACTTCTTCACAATCTC +CATAGCTTTCTCTTTCACCTCCGGCCAAACAAGCTCACTCAGCTCGCGGA +GCTTCACCTTATCCGAAAACACAATCGTTCCAAGCTTCCGGCGGTCTACA +ACTCCATCGACAACGACATCCCCTCCAAAATGTTCGCCGATTTTTCGATT +CAACGAGCTTCCCCGTTCATAGCACGTGTGTGCGAGCTTATCACAATCGA +TAACATCGAAATTATGCGTTTCACGGAGATATTTCCCGATATGACTTTTT +CCCGACGCAATTCCTCCGGCGAGCCCAATGATGTACGGGGCGCCCGTTTC +TCTTGGAACCGCCCGAGCTGGACGGAGCAAGTGACCCAGATCCTCTCGTC +GTCTGGAGCTTGAGCTGATCTTTGTCTCTTTCAGGATCTCATCGGATCCT +TCCACCAGCTCGACAATTATCACATCCAGCTGCGACATTCCTTGCTCATT +TCTCTTTTTGTTCACCGCATCGGCACCTTTAATGGTCTCCCGGGACACTA +CTATCGCTTCGAGGTCTTTTATTCGTGTTGAAGGACCGAATGGGTCGATT +ATTGGCTCCGCGAGACATTTTGCCTGGAAAATTATGGGGGTTCTATTGAG +CAAAAATGACCATTTTTGGAAAATTAGAAAATCGGAAAAAAAAATTTCCC +GAAATTTTTTATTTAGAAAAGTTTTTAAAAAACAGAAATTATATATTTTT +TGAGTTTTCCAAAACAAAAAATCGAAAAAAAATATTTCGATTTTTCGGAT +TTTCCAAAAGAAAAAATTTAAAATATCGAAGTTTTTAGATTTGCAATAGA +AAAATTGAAAAAAAAAACGGAAATTGTATTACGGGAACAGAAAATTCTGA +GAATGCGTATTGTACAGCATATTTGACGCGCAAAATATCTCGTAGCGAAA +ACTACAGTAATTCTTTAAATGACTACTGTATCGATCAAGCCCGTAAAGCG +CTACAGTAGTAATTTAAAGAATAACTGTAGTTTTCGCTACGAGATATTTT +GCGCGTCAAATATGTTGTGCAATACGCATTCTCAGAATTTTGTGTTGCCT +TAATGCAATTTCCGTTTTTTTTTCAATTTTTTCTTTTGAAAATCTGAAAA +TTTCGATTTTTTCCAATATTTTCTTTTGGAAAATCCGAAAAATCGAAACA +AAAATTTTTTTCTATTTTTTAAATTTTTTTTTTTGGAAAATCGGAAAAAA +ACCAAAATTTTAGTTTTTTAAAATATTTTATGGACCAAAAATATCGATTT +TTCCTAAAGTTTTATAGAAAACTGAAAAATTTAAATATTTATTGTTTTTA +ATTTTTAAATTTTTATGGAAAAATTTCGATTTTTTTTTTTGAAAAAAAAG +CTTTTTTTAAATTTTTCTTTATTTTTGGAAAATCGAACATTTGCTATTTT +TTTCGATTTATTAATTTTTTTGTTGGAATTTCTAAAAATCGATGTTTTTT +TTTCAAAAATCAGCGGTTTTTCCGAAAAATGGCAAAAATTTTTTTAAAAA +ACATTTATTTCTTTTCCTATTTTTCGAAAAATAAATAATTTTTTCTGGCA +ATTTTTAATGAATTTTTGATCGGTAAACTCTTACAGTCCCGGAAATATCC +TCTACAAAATCGACAACTTTCTTAATCCGAAACTCCACAGGCTCAATCAT +CTCGAATAATGATTTTTCTGGAAAAAAACCAATTTGTTAAAAGTTTTATT +TCCAAGCTATAATCTAACTAATAATCATATCCTTATCGGTGACCCCCACG +ACAATAACATCAGAAGCGAGCTCGGCAGCCTTGTTGAGCAACACTTTGTG +CCCATTGTGAAGCCGATCGAATGTGCCGCCCAACACGACTTTTTTGTACT +TTTTCGCCGCCGCCAATTTTTCCGCGTTCTCCAGCAGCTTTTCCTCGCCG +ATTAGCACATAATTCTCGGGATTTCCGCGGATTTCCGACACAACTAGACG +GACGTCGAGCTTCGGGCATGAGCTCGCCGATGTTAGGTAGATTTTCGAGA +CTAGCTCGTCGGTTCGCGGCTCGTCCGGGTTTAATCTGCAAGGAATCCTT +GTTAACCTTGATTTTCGAGCCGGGAAAAAGCCCAAAGCACTTTACCTCAC +ATAAAGCTTCGAGCTTAACGCGGCGGCCGCAGACGTGAGCAATTGCTTCA +GTTTTTGCACATTTTTGCTATTTAACACGAGAAGTCCGTATTTCGAGCTC +ATTGAGAATGATGAGAAATATCAGGGAATATTCCTCAAATTTTAAATAGA +AAAATTCGCTGCCACGTTCGCTGCTCTTATCGGCTGCGCGTCTCTATTTC +ACACACTGTCTCATCTCTCGTCTCGCGTCTCTCGTCTCTAACGCGTGACG +GTGGAGCGCACTTCCCTCCTTTTTGCTGTAAAATCTTTCAGACATGCCGG +AAACAAGAAAAACAAGAAATTATTGAACTGAAAATAATGTAAACGTACTC +ATCGTATTTTTAGCTTCAAAATAAGATATCTTAGAGCATATAATATTGCT +TCTAAACGAAAACCAAAACATCGCTGAAAATGTTGTGAATTTTATGAAAA +TCTAGGATCATTTTTCCCATTTTTATGAAAAACAACAATAAAATGAGAAA +AATTACATGGGAAAACCGAAGAAACTTAAATTTCGCGGTCAAAATTCGAA +TAGAATTACTGTATTTTTCGCTCAGAGATATTTTGCGCGTCAAATATGCT +GCGCGTGCGCATTTTCAGCGTTTTTTATTTAATAAAACAGTAATAAAATG +ATTAAATGCATTTTGTGTGATTTTCAGCCCAAAATGTTTGAAATAAATTG +TTGTTGTTCAAGCCAGCATTTTTAAAAACTTAAATATATGGGAAAACCAT +AAAAATAACACAAAAGTTTGGCAAAATTTTGGAACTACAGTACTCTTTAA +AGGCGCAAGCCCTTTAAGACAAATTTGTCGTGTCGAGACCGGACAAATAT +TCTAAATTTCTTTTATACATACGCAGATTTAAAGTACAGAAGAGCGCATT +TGCACATTGCGCAATTTCTAAATTTTTTCTAACAATAAAAATTAAAACCA +AAATACTTTATTCAATACCACAAATACCACAAGTTCATTTATCTTATTCA +ACCTCTTCCGCCGACGTCGTCTTGTTGTTGCTCTTCCCCTTCTTCTTAGA +CTTCTGAAATTTTCTCATATATGCAAACGCGCTCCGATCTAACAAAAAAC +CTTCTTCTTCTTTTTCTTCTTGTCTACATCTTCCTTCTTTGGCTGCTCTC +CAGATTCTCCCCCGGCTCCCGGATCGCTCTTCCCAAAGTCCATCTCCGGC +TTCAGCCCAACCTCAGGCGGCGCGATCATCAGTACCTGCTGGTATCCAGG +ACCCTTGTAATCCGTCATACAATCCCAATCTGGTGGCTCCTGGGTATTTG +ACTTAGACTTCTCAAACAGCTTCTGGATCCCATCAGCGATACGATCGTAC +TCCACAAACTCAGCGACATCCTTGGGCTCACGGATGATGGTCAGAAGATC +AAAGAACCCAGCAGTGGTCTCCGGAGTGGTTCTCCAAACCGACGCGACCA +TCGGTGCAGTGATGCGACGTTTCAAGTGGAGCACGTCCTGTTCGCTTTCC +TTGTTGAGCAGTGCCCATGGGAGAGCTCCGAGGAAGAACTCGAGCACCAT +GTACCACCAGGACTCCATGTCGTCCTTGTAGCCGAGATTTTTCTGGGAAG +AAAAAAGTTGTTTTAAAGAAATTGTGAACGGTAAGGTTACCCCCTGGTGA +GCATGAACGCTCGCGTACTTGACGACTCCTCTGTAGTGAATCGCATTCTT +TCTCATCTGCTCCTCAGCTTCGTCGTTCTTCTTGACGAATCTTAATTTTA +AAAAAAGTTTTCGGGGTAGATTTACGACGCGTTGCGTGTCGCGTCGCGGT +TCGATTTTAGTTGTAAAACTAAATGTATTTGTCCGTGTGGAGTACGCGAC +TTTCCCACTCAAAATAGGATGGAATTGAATTCGGAGGTGTCACTGTTGCA +AATTCGGATTGTCTGAATAAATATAAAGTGAGATTTTGAATTTTGCTCCA +TTGATAATGGTGTTTTTTTTTGAAATTCTGCAAACATTAATTTCTAGAAA +ATTTGAGTTTCCTCCAAAATTTTTCACAGAAAATTTGAATTCCCGCCAAA +ATTTTTTCTCTGAAAATTTGAATTCCCGCCAAAATTTTTTCTCTGAAAAT +TTGAATTCCCGCCAAAATTTTTTTCAGAAAATTTTGAACCCCGCTTAAAT +TTTTCTGAACTAGGCTATTTTGTCTCGGCCATATCTGGGGTTGTGGTTTA +CGGCGCGTTGCGTGTCGCGTCGCGGTTCGATTTTAGTTGTAAAACTAAAT +GTATTTGTCCGTGTGGAGTACGCGACTTTCCCACGCGTTGTTCGTCAGGC +AATTGTCAATGGAGCGCAAAAACTGCCGACCGCTCCAAATAACTACTTTT +TGCACTTCATTGCATACACACAGCAGCTCGCGGCGTCGGCATGAGGCCCG +CATTTCGCGCCTCACTGGAAGCCCCAGATGCCAAAAAATCTACCTCGGTC +TCTTGCACAACCCGAAATCCAACAGGTAAACCTGATGGTGCTGTCCGTCA +ATCTCTCTTCCAATACAGAAATGCGATGGCTTGATGTCGCGATGAATGAA +TCCATTCCGGTGGAGGTCACGAATCGCGGCCAGCGTCTGCTCGGCCAAGT +GAAGACCCGTCGCCATGCTGAACTTGCGATCCTTGTTCGTGTTCATCATC +AGCTCGTATAGGTTCTCGCCATACTGAAATATGGAATTTGGCTGAAGTTA +GGCAACGAAAAATGGTACCAATGGCATCACAATGAAGAGGAAGCGATTTG +GAACCGTGCCACGTTCCTCGATATTCGTGAAGAATGGAGATGGGTGGTGG +ATCGACGCGAGGACAACTGACATTTGACGAAGAAGCTGGAATTTTTTTTG +CTCTCTAGAAACGGTTTTCACGGCGGCCGACAATTTCCGAGTTTGGAAAC +TCACTGCACTTAGTCATGTAATTTTATAATGAGTGGCTAAACTCGGAAAT +TGTCGGCCGCCGTTAAACCACAAGACAGTTGGTTCCTTCGCCGCGACCGA +CACTTTCCGGGTTCCGCGCCGCACTATACAGAAGGCTGGCTGCGCGAGGC +AGGCTAGACCGCGGCAGGTGTTTTGGCGCCTACATGGACTTGCTAGCTTG +TCAACAAGGCAGCCTAAGCGTGCCTGCAAAAGGTAGGCAGGCACGCTTCT +AAAACCGTGCCAACACACCATAAATAACTCACCGAGCTCTTCATGTTCAA +CGCCTCGCATTTGACCGCAAAAAACTTCCCATCACTCTCGCGTTTTACCT +TGTAAATCGAGCCGAACGTGCCCGTCGCCAGCGGTTTCGTGACTTCATAG +GTGCCGTTTTGTGCTCGAATGAGCTCCTTTTGCGGTTGTCCAGGTCCGAC +TGACGTCATTGATTTAACACCGAAATGTCACGATTATTCGGAAGTGAATC +GATAATCGAAAATCGGAGACTCGAAACTTTTCGAAATAGATTTTATTATC +TTTGTAGGGTTTTTGGAGTTTATGATGATAATGAGGAGGGGGGATTTTAT +GTGGATTAAGAGGCTACGAGGAAAATATTTATTTTTTAAATATTTTATTG +TCATTCTTTTCTTTTCTAGATTTTCACGTTTCTTATTATTAAAAAAAAGT +TTTTCAGAATTTATTTCAAAATCCCGAACATAATCTGAAATTCAGAAATA +CTACAAAAGAAAAACGAAAAAAAAACTGAGAAAAATGGTCCAGATTCTCC +AGTATTGTTAGGCGTACCCCCCCCCCCCCCCTACCTACCTACCTTCCTTC +CTCGCCTACATGCATACCTGCCTACCTACACGCCTGAGTGCCTGCCTACC +TTCCTGCCTACGTTTATGTCTACATTTTTTGCCAGCCTTTTGCCAGTATA +CTTTACGTGTGTTCTTAATTACGTGCCTATCTACTTACCTTTCTTCCTCG +CCTACATGTATACCTGCCTACCTACACGCCTGCGTGCCCGCCTCCTGCCT +ACCGACTCACCTACCTGTTTGCATACATGCCTGCCTACCTTCTTGACCAT +GCCGAGGCGCCTATCTTACTACTTGCCTACCTACACGCCTGTCTATTGCC +TACCTGTTTGGTTACATGTGCCTGTGCCGTACCTGTGCCTCAAAAACATC +TTTATTTTGTAATAAATAATTTTAATAAAACTTTATAAAACAAAAAAAAT +ACAAAATTGAAAATAACCTAACAAAAAGTCTTTTCAAACCCCTTCGAACT +GCTCAACTGATAAAAATTCGTGTTATACTTCAACAATTTGAACTGCAAAT +CCGATTTGACACAGCTAAACTTGTATTTTGTCGCTTTATTCCTGCACAAA +TGTGCTCCTGGGCAATTGAGACTATTCGAATCGGTGTAGTAGGTGGTGAA +GCTCTTTGAGCATCTTATTGTAGAGTGATCTTCTCGAAGACGGCCCAGAA +TTGCGGTGATTGAGGGATTTGTGATGGTTCTGGGGATTTGATGTAATAAA +TTTAAATTGTGTGGTTTAGATGCAGAAAAAAAAACTAAGAATTCAGACTA +AGACTTGAAAAAGAGCCAAGAAAAGGGCGGAGCCTATTATCGATTTTTCC +ACTTGCCGTTTATGAAGTTTATCTACACTTATATAGTCTATTATCAATAC +TAAGTTAAACAGTATATGGTATAATAAATACTATGACTGCAAGAAAAATC +AATAATAGGCTCCGCCTCTATATTTGTTTTTTCTCGTTTTAAATCCAAAC +TTATTCTACGCCGAACCTATATTCTTTTATATTTTTTGAAATTATATATC +CTTCTATTTATAAGATTTTTCCAGCCAAATTTTTTTTTCTCAGAAAAATT +GAGTTTCCCGCCAAAATGGGTTTCTCAAAAAATTTGAATTTCCCGCCAAA +ATTTTTTTTCTCAGAAATTTAAAATTTTCCGCAAAATTTTTCTCAGAAAA +TTTGTATTCCCCGCCAAAAATGTTTTCTCATAAAACATGAATTTCCGTCA +AAACTTTCTCATAAAATTTGAATTTCCCGCCAAAATTTTACGAGAAAATT +TGAATTTCCAGCCAATCTTTTAATGAGAAAGTTTGAATTCCCACCAAAAT +GTTTTTTTTTCTCAGAAAATTTGAATATTCCGCAAAAATGTTCTGAGGAA +AATTGAATCTCTAGCCAATTTTTTCTCATAAAATTTGAATTTCCGGTCAG +CTTTTTTCTGAAAAAGTTTGAATTTCGCGCAAATTTTTTTTCTCAGAAAT +TTTAAACCTCTGGCTTTATTTTTCTCAAAAAAATTAAAATGTCCTGCCAT +TTTTTTAAAAAAAAAATTCACAGAAAATTTGAATTTTTAATTTTAAAATT +CACAGAAACTGACTTCCTTATCGACATGCCAATTGTCACACGATCCGCTG +ATTTCAGAGCTTCACCGCCCGTAAAATTGCCACGTATCATTGAATCCACG +TCAGCAGAGTCGGGAATTTCAAAAATTTTACTATCATCCATTTGTTTGCT +GGAAGCGTTAATTATCGATTTTTATTTTTTTATTCGTTATATTAATTTTA +TTCATATTTTTTGAAAAATAAAATCAATTTCACTCTCGGATTTCTGGCTT +CCCTCATAAAATGAAATGAAAGAGTTTGCCGAACTAGGCCATTTTGGCTC +GGACATATCTGGGGCAGATTTACGGCGCGTTGCGTCGCGGCTCGTTAAAA +ATAGATTTATTTGTCCGTGTGGAGTACACGACCTTCTCACGCGTTGTCCG +GCAGGCAATTGTCAATGGAGCGCGAAAAATTCAATGAGGAAGGCCAGAAT +CCCGTGTTCACTGATTTTTTGAATTTACAATTTTTAAAGTATCGAATAAA +AATTTTAATTGAAAAAATCGATTTTCAAAAAGTTTTAAAATTTTTTTAAA +ATTTGAATTTAAAAATCGATTTTAAAAATTATTGATTTTCGAGCAAACCT +TTTCAATTTGTACGGATGTTCCACGGGCTCATTGAGCCAAACACTATCGA +TTAAAGATGGGCGTGTCACCACTTTTGCCACGCCCCTTTCATTCCGATAT +TCCAATAACCCGACGAATATCTCTGATTCGTAATAGTTGGCGAACTCGGA +AAAATAGGAATCGAACGATTTCGGCACGAGAAGATCAGACCACTCGAGAA +ATGTGATGAAGCTCCCCGAGCTCTGAAAGTTTGGATAAATAGAGTTGTGA +GCCTAGTGCAAGTTGAAAAAATCGATAAATTATCGATTTTCTGATTGTAC +GAATTTAGGCGGGAATTCAAATTTTCTGAGAAAAATTTAGGCGAGAATTC +AAATTTTCTGAGAAAAATTTAGGCGAGAATTCAAATTTTCAGAGAAAAAA +TTTTGGCGGGAATTCAAATATTCTGAAAAAAAATTTGCCGGGAATTCAAA +ATTTCTGAAAATAAATTTAGGCGAGAATTCAAATTTTCAGAGAAAAATTT +TGGCGGGAATTCAAATTTTCTGAAAAAAATTTAGGCGAGAATTCAAATTT +TCTGAGAAAAATTTAGGCGAGAATTCAAATTTTCAGAGAAAAAATTTTGG +CGGGAATTCAAATTTTCTAAGAAAAATTTTGGCGGGAATTCACATTTTCT +GAGTAAAACTTTGGCGGGAATTCAAATTTTCTGAGAAAAATTTAGGCGAG +AATTCAAATTTTCAGAGAAAAAATTTTGGCGGGAATTCAAATATTCTGAA +AAAAAATTTGCCGGGAATTCAAAATTTCTGAAAATAAATTTAGGCGAGAA +TTCAAATTTTCAGAGAAAAATTTTGGCGGGAATTCAAATTTTCTAAGAAA +AATTTTGGCGGGAATTCAAATTTTCTGAGTAAAACTCTCTGGCGGGAATT +CAAATTTTCTGAGAAAAATTTAGGCGAGAATTCAAATTTTCAGAGAAAAA +TTTTGGCGGGAATTCAAATTTTCAGAGAAAAAATTTTGGCGGGAATTCAA +ATTTTCTGAAAAAAAATTTCGGCGGGAATTCAAATTTTCAGAAAAAAAAT +TTTGGCGGGAATCCAAATTTTCTGAAAAAAAATTGGCCGGGAATTCAAAA +TTTTTGAAAAACATTTTCGGCGAGACTTCAGGGGTTCTCATAAGAATTCA +AATTTTCTGCAAAAAATTTTGGCGGGAATTCAAAATTTCTGAAAAAAAAT +TTGCCGGGAATTCAAAATTTCTGAAAATAAATTTTGGCGGGAATTCAAAT +TTTCTGCAAAAAATTTTGGCGGGAATTCAAATTTTCTGCAAAAAATTTTG +GCGGGAATTCAAATTTTCTGAGAAAAATTTTGGCGGGAATTCAAATTTTC +TGAGAAAAATTTTGGCGGGAATTCAAATTTTCTGAGAAAAATTTAGGCGA +GAATTCAAATTTTCAGAGAAAAAATTTTGGCGGGAATTCAAATATTCTGA +AAAAAAATTTAGGCGAGAATTCAAATTTTCTGAGAAAAATTTAGGCGAGA +ATTCAAATTTTCAGAGAAAAATTTTTGGCGGGAATTCAAATATTCTGAAA +AAAAATTTTGGCGAGAATTCAAATTTTCAGAGAAAAATTCTGGCGGGAAT +TCAAATTTTCTAAGAAAAATTTTGGCGGGAATTCAAATTTTCTGAGTAAA +ACTTTGGCGGGAATTCAAATTTTCTGAGAAAAATTTAGGCGAGAATTCAA +ATTTTCAGAGAAAAAATTTTGGCGGGAATTCAAATATTCTGAAAAAAAAT +TTGCCGGGAATTCAAAATTTCTGAAAATAAATTTAGGCGAGAATTCAAAT +TTTCAGAGAAAAATTTTGGCGGGAATTCAAATTTTCTAAGAAAAATTTTG +GCGGGAATTCACATTTTCTGAGAAAAATTTTGGCGGGAATTCAAATTTTC +TGAGAAAAATTTAGGCGAGAATTCAAATTTTCTGAGAAAAATTTTGGCGG +GAATTCAAAATTTCTGAAAATAAATTTTGGCGGGAATTCAAATTTTCTGC +AAAAAATTTTGGCGGGAATTCAAAATTTCTGAAAAAAAATTTGCCGGGAA +TTCAAAATTTCTGAAAATAAATTTTGGCGGGAATTCAAATTTTCTGCAAA +AAATTTTGGCGGGAATTCAAATTTTCTGCAAAAAATTTTGGCGGGAATTC +AAATTTTCTGAGAAAAATTTTGGCGGGAATTCAAATTTTCTGAGAAAAAT +TTTGGCGGGAATTCTAATTTTCTGAGAACATTTTTGGCGGAAATTCAAAT +TTTCTGAGAACATTTTTGGCGGGAATTCAAATTTTCTGAGAAAAATTGTG +GCGGGAATTCAAATTTTCTGAGAAAAATTTAGGCGAGAATTCAAATTTTC +AGAGAAAAAATTTTGGCGGGAATTCAAATTTTCTAGAAATCAATTTTTTC +AGAATTTCAGAAAACACCACCCCGGCTATCAATGGAGCGCATTTTCAAAG +TCTCACTTTATATTTATTCAGGCAATCCGAATTTGCAACAGTGACACCTC +CGAATTCAATTCCATCCAATTTTGATTTCCCATAAAAATCTGGAAACGAG +TCAACTGATATTCCTTTGAGACGCTTCAACTCTTCTAGAAATTCGAAAAA +CGGGCGACTTGTAGTTGCCACGTATGTTTGGAGATGGCCGCCGAAACTGG +AAAAAAAATTTAAAATAAACTGACAAGTCTATATATTTTTTCTTTAAATT +TTTTTAATCGAAAAGCACCCCTATTATATAAATTCTTTTTTAACCTACCA +TTTTTAATAATTGATGGCCGAGTTTTCTTTTTTAGGCCATGTTCAAAAAG +CCGGTCGGTACCGGTTTTTGGTGACCGAATTTTCAAATTTTCTAGGCCAC +GTAGAAAAACCAGGTCTTCTTTTCACACATTGATTGTTTAATTTTCTCAA +AGAACCCCCTCTCCTATAAAATCACGGTTAATAATGGGCGATAAGTCGAT +GGCCGAGTTTTTTTTATATATTTCTAGGCCATGTAGCAAAAACTGACCCT +TTTTAACCCCAGAATGTTCTCAAAAATCGTATTTTTTAATTGTGGAAAAG +CCCAGAAAATTATGTATGCTGCAAAATCACAAGTCGGCGGCCGAGTTTTC +TCTCTTCCTAGGCCACGCTGCAAAAACTAACCTTCCGTTTACATATTGAC +TTTTTCAAATAATTTCAAATAAAAATTATTCACTTATAAAATCATTTACT +TCATGATTGAAAGCTTTTGCAATTGGTTAAAACCGGAAATAAGTCGATGG +CCGAGTTTTCTCTTTTCTAGGCCACGTACCAAAAGTGTCCCTTTTTTACC +CCAGAATGTTGTCAAAAATCGTACTTTTTATTTGTGGAAAAGCTCGGAAA +ATTATGTTGTAAAAAATGAGTCAAGTCGGTGGCCGAGTTTTCTCGTTTTC +TAGGCCACGCTGCTTAAACTGACCTTCCATTTACATTTTGGCTTTTAAAT +TCAAATAAAAATTATTCCCTCATAAAATCGTTTACTGTCATTGTGAGAGC +GGTTAAAAACAGGAAAAAAAATGGTGGCCGAGTTTTTTTTTCTAGGCCAC +ATAGCAAAAAACTCACCTAGTATACACATGAGCAGCTAACAACACATTCT +GCCATCTAACATTATTATAAATAGGCGGAGTACATACAACCAAATCCTTC +GGCTTATTATCCGCCGGCAAATATCGAATTTTCGCGGTATGCCCATTCAC +AAGAAGCTCCAGCTCCGTGAGCTCTTCCTCAAGCACTATAGTACCCACAA +GTGTCACGTATTTGCATAAATTATGCGGAGTTGCTCTGTGAATTTGAAGT +GGTTCGAGTACGGTTTTTGTGTCGTCACTTCGGATTGCGATAATCTTACG +ACGTTCCCAATGTGCATCCCGAGGCGCGATAAAGGTTAGTGTTACTTGGT +TTTTGTAGAGACTGAAAAATTTCAAAAAACTTAAAAACTAACGTAGTTTA +AAACATTATTCTTCTTTTTTTATTCTGAGATATTTTGATTTTGAAAAAAA +AAAATTTTTTTTACGAAAAAAAAATTGGCAAAATACCTCAAAAACTGTGA +GTTTGTTGAAATTTAGTTTTTACAACCACGGGAATTAATTTTTTAAATTA +AAAATATTTTACGTGTAGTCCTCTCGAATAATTTTGAAAAATATATGAAG +TGTTGAATTCTGCCGAGTTTTTTTGTCCGAGTGGACTACAAAAGTGCAAA +GAATTTGGAATTTTTCAAACTTTATATTTAACAGCAATCATCAACAACTT +AAAAAAATTTAGATTAAAAAATTTTTTTTGGAAGTTTTCGAAAAAAATTT +TGGAAAAATTTTTAATTTTCAGAAAAAAAAACCAGTTTGATTTTTTTCTT +AAATTCTTTTTTGAAAATTTGTTGAAACTTTTTTTTAAATGCTAGACTTT +TTTTTTGAATTTTCACGCGGTTCTGGTTTCCCTCATATTTTGAGATAGAA +GAGTTTGCCGAACTAGGCCATTTTGGCTCGGCCATATCTGGGGTAGATTT +ACGGCGCGTTGCTTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAAA +TGTATTTGTCCGTGTGGAGTACACGACTTTCCCACGCGTTAGGCGATTAT +CAATGGAGCGCGAAAAATGCAATGAGGAAGGCCAGAACCCCGTGAAAAAT +ACATTTTAAAAAATACTTGAAAAATGTTTAAATTTTCTTTTTAATTTTAA +ATTTGAAATTTTGTAACTTTACAAAAAAATAATTTTTCGAAATTTTTTTC +AAATATTTTTTTTCGAATTCTTTTTGTTGAAATTTCAATTCTCTGTTCTA +AAAATCAATATTCCTTACCTGTATCCCACTCCATAATAGTACGCAGAAAC +AAAAAATAGGTCTTTCTCGTCGTTATCCAATTCTTTAATCTTATTAGTGT +ATGAATTTCGAACACGTCTTAATGCAGGCAAGGGATGTATTGAAATATGT +ACAAATGCTAATAATATTACAAATAGATATAGGGTCCTGCAACGAATTAT +CAACTGCTCGTAGAGTACGGAATAGGGTTTGAATTGAAAATTGTTCAGTT +TCGTGTCGGAATTCATTTTTATTATGGGGAGGAAAACAATCTAGTGTGGT +GGTAGTGGTAATGACAATCGCTATTTGAAATCATGTTGAATAGCTGCGAT +AAGTATCGGGCGCCAGCGTGGCCTAGGATTTGGGAAAACTCTTCCACCAG +AAGCTAGTCGTGGCCCAGGCTTTGAAATTTGATTATTTGATCAAGAAATT +TACAACTAAATTTAAAATCAACAGTTAAGACATTTTTCATAGACTTTTCG +AAAAATTTCTGATTTTTCCATATCAAATAACCTCGGTACGCATCTAACCG +TCAGTTGCCTCGTGGCCTAGAACTTTTGAAAACTCTTCCACGAGAAGATC +ACCGTAGCCTAGAAAGTTTTGAAACTTGTGTAGTTCGCTTGGAATTTTTT +TTTGGTTTTTTTGTCAACTAACTAGGTTCAATAGCTATTAAAAAGTTGCA +AAATTGGGCAATTTTTGTAAAAATTCACAATTTTGAAACTTCTCTAAAAT +TATTAATTTTGTAGTAAGAGGACTCAAAATTGATCTTCAAACACTAAAAA +ATAGCCCCTTTTTAGAATATAGTGGTTTCGAATATTTTTTGAAAAATTAT +TTTTTTTTACCCAAAAAAAAGGACAGTCATGGCTGAAAAAAAATTTGGAA +AAAATAAAAAAATTGTCTAAATTTGTTGAAAACGGGTAATTCATGCATTC +TGAATTCAGAAAATCTAGGTTTAACCCATCAAAAACCATTAAAAGCGGCA +AAAATGGGTATTTCATTGTAAAAATAATGCATATACAATAAACAATGTAG +AGGAATGTTCAAAATCTGTAGTTTTTTTGAAATTTTTTTTTTATTTTTTG +GTTATTTTTTTTGCAAATTTTCTCGTATATTTAATTAGTTAGTTTGCATG +TTACATGCTAATGAAAAGGTTTTTTTTGCATCCTGATACATATAAAAACC +GAGAAATTCACAATTTCACAATCAGTAAGGTATTTAATTTTTGTTAACTT +TAGTCTTCTGCTCCTCTAAAGCTTCTGGAAGAGGACACTTTCTAAATTTT +CAAAATATTTTTTGCGCCACTTTCCTGTCAAATTTCTGGCATTATTACAT +CCAAAACCCAATAAAAATCGGAATTCCATAGCTACGACAACGTCAGCAAA +AGCGGAAAGAAATTTTGTTTGCCTGTCTAACGAGTCACAAAGCATACACT +GACGTTTCTATCAGAAAAGACAGGATTTCGTATCAAAACAAAAATTGGGT +GCGATTGCTCGATGCACCATGTGATATTTTGCTTTTTTTAAAAATTATTT +TGCTCGTAATGTATGGTGCACTTATTCCGTGGCTGCAGAATTTGCACGCG +GTGTCATAATGCCCATTTCGACTTGATCTACGTAGATCTACAAAAAAATG +CGGGAGTTGAGACGCAGAGGTAGGGCTCAACTGATTTCGTTTGGTTAAGA +GCGTGCTGACGTCACATTTTTATGGGCAAAAAATTCCCGCATTTTTTATA +GATCAAACCGTAATGGGACAGCCTGACACCATGTGAATGCAAACTTTACG +CGAAAATTTTTAGATTTTTAATAATCTTAGAATTAGCTATGGTTTTATAG +AATAATATCAAAATTATCCAAAAAAAAAAACACATTTTTTCAAAATTTTA +GATTTCCAGTTTCTATTTGAACTTTAAAAGACTAATCCAAATTTTGTTTT +GTTTCAACGATTTTTCATTGATCTCTCCAAAGAATTCATTGAAACACATC +ATTCACAAAACTAAAAACTCCCCGACTTGGCTTTCATTCCGAGATGACAA +ACTTTTTGGTGGCAAAGGTTCTTTGGGGGCATAGTATCCAAGGAGACAAA +GTATCCAGTAGACAAACTGGGGTGTATCTTGGGGGGCATATCTTTGGTGA +CAACCTTTTTTTCGACTAGATTTTTATATGTATTTTTCAACTAATTTTTG +TTCACATTTTTCTGGAATAAGTTTTTTAATGCAATTTTCAATCGATTATC +GGTTATAATTCCCTCACAATTGAATGTATGAACGATGGTCTTTTGGGAAA +AGCTGTAAAACGTCCAACTAACTTGGAATATCGTGAGGCTCTTCCTGATG +GTCTGATCCTTCAGCTCCGAAGGATCACATGGGTACCTTCTGATGTTCTG +ATCCTTCAGATAAGAAGGATCGTAAGGGTACCTCCTGATGGTCTGATCCT +TCAGATCCAAAGGATCACGAGGCTCTTCCTGATGTTCTGATCCTTCAGCT +CCGAAGGATCACATGGGCACCTTCTGATGATCTGATCCTTCAGATAAGAA +GGATCGTAAGGGTACCACTTGATGGTCTGATCCTTCAGCTCCAAAGGATC +ACGAGGCTCTTCCTGATGTTCTGATCCTTCAGCTTCGACAGATCATATGG +ATTTTTGACAAAATTTGAAAAAAAAAATTTTGAAAAAAAACTCGAAATTT +TTTTTTGTTATTCTTCATTCTTTAAAGAATAGTTCAAATTTATCATGATA +GGACCGAAAACTTTCAAGAAACAGTATAACTATACATGATAATCAGCTTC +TACCAAATAATGATAAATTCTCCGCGATGACAAACTTTTCGGTGACAAAG +TATCTTGGTGGACAAACAAAAATTACCGAAAACTGATGTAAGGAATAGTG +AAATAGAGTCCTATGGACTATTAAACATGTTCAGTAGGTGTATTCAGGAC +TGTCCGTCAAAATAAAAAAAAGTTTGTCAGACGAAGTTCGAACCTGGGAC +CTGTAGGATGCAAAGTGCGCTCACTACCACTACACCAGCTATGCGAAAGT +CGGCGAGCCTCATCGAAGGCTATTATAAAACTTAGTTCGCACGAGTATGA +TCGACATTCAACAAACAGTAATATCTCTCAACAAGAATTTCTTCATGGAA +TTGAGGTCATTTGACTATTTTTATCGGTTTTTCAAGTTGAGCATAGGGTC +TTTTAATTTTTTGAGCATAGAAAATCATGAAAGCTGCCTGTTCCTTGTAT +CCTGGATCGAAATAGACGTATCTGGCCTAAAATATTTCCTGAACAGTGAT +CATTTCATGTCCATTGTGTGTTTCTCTGTATTTTGAACCAGAAAGTTGAA +CAAAAATGATAATATTATATCGAAAAATGGAACAAATACAAATAATTTTT +AGGCCTAATCAAATTTCCTCCGGATATTGTTTTTTTTGTCATGATTATAT +GTGTCTAAATTTTTTATAATGTGTTTTATAACAAAATTCGTCATTATTTC +CTTCATTTCAAGCAAAATTTAACAGTTCGAGCTTAAAAATAGATGTTGCA +AAAAATTTAATTCGTTTCGATGAATACGGTATACGGTCGGTGTTTGCGTA +CTTTGGCGTTTGCGTATGAAGCATCCTATTTGACGCACGAAACTTTCAAT +GAAATTTAATGCAAATTCTGCATCGAAAAGGACATTACGATGGAAATAAT +GACGAATTTAATTATAAAACACATTATAAAAAATTTAAAAACATATAATC +ATGACAAAAAAAACAATGTCCGGAAAAAATTTGATTAGGCCTAAAATTTA +TTTTTTATTTTTTTCCATTTATCGATTCAATATCAACATTTTTGTTCGAC +TTTCTAGCTCAAAATTCATAGAAACTCACGATGGACATGAAATGATCACT +TTTCAGGAAATATTTTAGGCCAGATACGTCTATTTCGATCCAGGATACAA +GGAACAGGCAGCTTTCATGATTTTCTATGATCAAAAAATTAAAAGACCCT +ATGCTCAACTTGAAAAACCGATAAAAATAGTCAAATGACCTCAATTCCAT +GAAGAAATTCTTGTTGAGAGATATTACTGTTTGTTGAATGTCGATCATAC +TCGTGCGAACTAAGTTTTATAATAGCCTTCGATGAGGCTCGCCGACTTTC +GCATAGCTGGTGTAGTGGTAGTGAGCACACTTTGCATCCTACAGGTCCCA +GGTTCGAACTTCGTCTGACAAACTTTTTTTTATTTTGACGGACAGTCCTG +AATACACCTACTGAACATGTTTAATAGTCCATAGGACTCTATTTCACTAT +TCCTTACATCAGTTTTCGGTAATTTTTGTTTGTCCACCAAGATACTTTGT +CACCGAAAAGTTTGTCATCGCGGAGAATTTATCATTATTTGGTAGAAGCT +GATTATCATGTATAGTTATACTGTTTCTTGAAAGTTTTCGGTCCTATCAT +GATAAATTTGAACTATTCTTTAAAGAATGAAGAATAACAAAAAAAAATTT +CGAGTTTTTTTTCAAAATTTTTTTTTTCAAATTTTGTCAAAAATCCATAT +GATCCGTCGAAGCTGAAGGATCAGAACATCAGGAGGTACCCATGTGATCA +TTCGGCTCTGAAAGATCAGATCATCAGGCAGAGCCTCATGTTCTTTTGGA +GCTGAAGGATCAGAACATCAGGAAGAGCCTCATGATCCTTTGGATCTGAA +GGATCAGACCATCAGGAGGTACCCTTACGATCCTTCTTATCTGAAAGATC +AGATCATCAGAAGGTACCATGTGATCCTTCGGATCGGAAGGATCAGATCA +TCAGGCAGAGCCTCATGTTCTTTTGGAGCTGAAGGATCAGAACATCAGGA +AGAGCCTCGTGATCCTTTGGAGCTAAAGGATCAGACCATCAGGAGGTACC +CTTACGATCCTTCTTATCTGAAGGATCAGAACATCAGAAGGTACCCATGT +GATCCTTCGGAGCTGAAGGATCAGACCATCAGGAAGAGCCTCACGATATT +CCAAGTTAGTTGGACGTTTTACAGCTTTTCCCAAAAGACCATCGTTCATA +CATTCAATTGTGAGGGAATTATAACCGAAAATCGATTGAAAATTGCATTA +AAAAACTTATTCCAGAAAAATGTGAACAAAAATTAGTTGAAAAATACATA +TAAAAATCTAGTTGAAAAAAAGGTTGTCACCAAAGATATGCCCCCCAAGA +TACACCCCAGTTTGTCTACTGGATACTTTGTCTCCTTGGATACTATGCCC +CCAAAGAACCTTTGCCACCAAAAAGTTTGTCATCTCGGAAAGAAGGCCCC +CCGACTTTGCGCGTAAGATATGGTGAGACCCTAATACATCATATTTGACG +CGCAAAATATCTCGTAGCGAAAACTACAGTAATTTTTTAACCGTCTACTG +TAGCGCTTTTGTAGATTTACGGGATCTCGATTTTTTTAATGATTAAAATT +AAACAAAAAATGAGAAAAGAACACGAAGAAACGAAGAAAAATGAAATATC +GATGTCACTTTTCGGAAAAAAAATTAATTTCAAAAATTGAGCCCGTAAAT +TTACACATGCGCTACGGTAGGCATTTAAAGAATTACTGTAGTTTTCGCTA +CGAGAAATTTTGCGCGTCAAATATATCGCACAATACGCATTCTCAGAATT +TTGTGTTCCCGGAATAATTTATTTATTGGTTTTTTTGGTTGTATTGGTCC +CAAAAATCAACAAAAAAAAATTTTTATGAAAAATTTCTGTTTTCTTCCGT +TTAAAATCAAAAGTTGGTTTTTTTTGTTGCTTTTTTTGATAAATTTTTGC +AACCACCCTGATTTATATTCCCATAAATATTTAATGTCCCGCTTATGATA +TCTACTGCTTCTTTGCAAAATTCCTACCTGCGGACCAAATACACCATACT +TGACGCGCACTTTTTTTTTGATTTTCAGCTGGACAAACACATTTTCAGCA +TGATTCTGACTTATTTATTTAACTCTTATCACTCTTATCGTTAAAAAACG +CCCTTATAATCATCAACCTATTTTCATTGTCATTCAAAAAAAAAAACTAT +TTCGTACTCGTCGATCGTACTAATTTGTCATCGTTCCGTTCCGTCGAGCA +AAAATCAATGTAGTTTTACGTTTTCCGTTGAAAAAAAATCCAAAAAAAAA +TCCAAAAAAAATCCAAAAAAAAATTCCTTGTTAATTAAAACCGTGAATAA +AAAATTCAAATAAAAAGTTCAAACGTTTCGTTATAAAAATGTACACCGGT +AAGCTCAAAAATATACATTTCAGATTCTAACAATGTGCGACGATACGCTC +GCATTTTGTAGTCCAGCTCCATTCAGTGATGATGTAGAGGTTATTAAACA +ACGTGAGGCGATCGATTATTCCACACAAATCACTCTGGAAGATGCGATTT +CTGGGAACGGTAAGTGCGCTCCGTTGTACTCATAGTTCGCTGAATGAAGG +CATGTATAAGTTCTCAAATTTTCAAATGAAAATTGCCAAAAAAGGTTTTT +AGTTAAAATTTAAAAAATTATCGATTTTTAAATTTATGAAAATTTTTTCG +AAAAATTTGTGTTTTTTGTTTTTGTTTTATTGATTTATTGATTTTTTGGC +GAAAATGTGAAAAATCGAAAAATTATGGATTTTTTCTTGGAATTAAAAAA +AAAAAACTTTATCGGCTAAGCGAAACTTGCTTTTTCGGTTTATTGATTTA +TTGATTTACTTGAAAAAGTACTTGAAAAAATCAATACTTTTATCACGGGG +ATCTGGTCTTCCACATTAAACTTTTCGCGCTCCATTGAGAATCGCCCGCC +GGACAACGCATGGGAAAGCCGTGTACTCCACACGGACAAATACAATTAGT +TTTACAACTAAAATCGAGCCGCGACGCGACACGCAACGCGCCGTAAATCT +ACCCCAGATATGGTCTGGTCTAGTTCGGCAAAAACTCTTCCATTTCAATT +TATGAGGGAAGCCAGAAATCTTTGTTTTTATTTTATTTTGAAATCTCTAA +ATTATCGATTTTTTGGAAAAAAAGTTGTTTGAAAATTCGATAATTTTTTA +ATGATTTTTTGGAAAAATTAAAATTTTCGCTTTTCAAAAAAATCAAAAAT +TATTGATTTTTGAAAAAAAAAACACGGCATGCAATTCCTAGACCACCAAT +CAAAAACCTCTTCCAGTGACTCGTCCGGTCCGTGTCTACGCTGACGGTGT +CTACGATATGTTCCACTACGGCCACGCGAATCAATTCCTGCAGATCAAAC +AAACTCTTCCGAATGTCTACCTTATTGTTGGCGGTGAGTTCGGCCCGCGA +AATTCAAAATTTTTAATTTAAAAAAAAAACGATTTTTTCCAGTATGTTCC +GACGAAGAGACTATGAAGAATAAGGGGAGAACTGTGCAGGGCGAAGAAGA +GCGGTACGAGGCGATTCGGCATTGCCGGTACGTCGACGAGGTGTATAAGG +CGTCGCCGTGGACATGTCCGATACCGTTTTTGAAGGAGTTGAAGGTAAAT +TGCGCGTGAGATTCGGTGTTTGCACAGTTTTATCTCCAAAAACGAAGGAA +ATTTTATACCTAAATTTCGGAAAAAAATCAATAAATTATTGCCTTTTTTA +AACGTCACAAAATCGATAATAATTTGAAAATCACAATTTTTTTTTTATTT +TCAAAATTTCGTTGTTCTATCACGGGAACGCAAATTTCTGAGAATGCGTA +CTACACAACACATTTGACGCGCAAAATATCTCGTAGCGAAAACTACAGTA +ATTTGTTAAATGACTACTGTAGCGCGCTAGTGTCGATTTACGGGCTCTAT +TTTAAGCTCAATTTTAATTTCTATCGATAAATATATGATACAAAATATTG +ATCCCGTAAACCGACACTAGCGCGCTACAGTAGTCATTTAATGAGTCACT +GTAGTTTTCGCTACAAGATATTTTGCGCGTCAGATATGTTGCGCAATACG +CATTCTCAGAATTTTGTGTACCCCGTAATAAAAATTCGAGTTTTTCTAAA +CAAAAAGTTTAATTTAAAAAACCTCTAATATTCGAGATATTCGATTGGCG +ATTTATTGATCTATTGATTTTTCGATAAATATTGATTTTTCAATTTTTAC +AATATTCGAAACAATTATCGAAATTTCAAAAAACTAACAAAAAATATTTG +CGGAGGAAAATCGATAACTTTTCAATGTATATTTTCTGAAATTCCATAAA +ATTGATTTTTCTAAATTTAATTTGTTCGATTTTCGGGTTCTCGGTTTTCC +TAATTTCTGTAATTTTGAGTCGATAATTTTTTGTTTTTTTTTTTCAATTG +AAACTTTTATTGATCAAGGATTTCTGGCTTCCCTCATAAATTGAAATAAG +AAGAGTTTGCCGAACTAGGCCATTCTGGCTCGGCCATATCTGGGGTAGAA +TTACGGCGCGTTTCGTGTCGCGTCGCGCCTCGATTTTAGTTGTAAAACTA +AATGTATTTGTCCGTGTGGAGTACACGACTTTCCCACGCGTTGTCCGGCA +GGTGATTGTCAATGGAGCGCGAAAAATGCAATGAGGAAAGCCAGAACCCC +GTGATTGATTATTGAGTTTTGGAAAACTATTTTAAAAAACCTGATTTGAA +AGAAAATATCGGTAATTTTTCGGATTTTTAACAAGAAAAAGGTTTTTATT +TCCGGAAACTTTCATTTAATAATTATTTATTTATTGATTTCTCGGAAAAA +TTTGCCGAAATCTATCGAACTATAGTCGAACAATTGGACGAAAAGTCGAA +AAAAAAATTCTAGGCCACGAATTTCCTCTTCCAGGTTGACTTTATGTCAC +ACGACGCTCTGCCATACCAAGGTCCCGCCGGAGAAGACATCTACGAGAAG +CACCGCACTGCTGGCATGTTCCTGGAGACGCAGAGAACCGAAGGAATATC +GACGAGCGATTCGATTTGTCGAATTATCCGCGACTACGACACGTATGTCA +GAAGAAATTTGCAGAGAGGATATTCGGCCACCGATTTGAACGTTGGCTTT +TTTACAGTGAGCCTGGCCTAGAAAGGGGTGGCCTAGAAAGAGGTGGCCTA +GAAAAACAAAACTCTTCCATTTTTTTCAGACCAGCAAATATCGTCTGCAA +GACACCGTAGTGGGAATAAAAGAAATGGGCCGTGGCCTGCTGCAAACGTG +GAAAACGAATGCGGATTACTTGATTGAAGGATTCTTGACGACATTTGCCA +TCAGTGATCCGAAACCGTTGCCGAACAACAAAAGTGCCGATGAAAATGTG +GAAAATAGGGAGAATATTGAGAATTTTTAGAAAAAATTCGTGTAAATTAT +GGGAATAAAAATTTGAATACTCGTGAATGTTTACTGAATTTATGCAATTT +ATTTTTTGAAATTTTCAATTTTTTTGGAAAATTTTTTTTTCTTAGGCTTA +GGCTTAGTCTTTGGCTTTGTTTTAGGATTAGGCTCAGGCTTAGGCTTAGG +CTTAGACAAAAACTTAAGCTTAGGCTTAGGCTTTTGATTAGGCTTAGGAT +TAGTCTGTCTTTCACTTAGGTTTGGCGTCATTGGCGAGCGTTAGCTCGCT +ATTTAGGCTTGGGTTAATTAGGCTTAGGCTTAGGCCTAGCTTTAAACTTA +GGCTTAGGCTTAGGCTTAGAATCAGGCGGGCTAGGGAAAAAAAGAGAAAT +TCCAAAAATTCCAGAAAAAAGGAAAAAAGGTACATCCCGAAGTCGGGTCA +AAAAATAAAGTGAAGAAATGAAATTTTCACGAAAATGAATGAATATTTTT +GAGTCTCGCGGATTTATTTTCATAATCATATTCTGAACGTATTATTGACT +CGTCGTGTGGGACATTTCAATGGATTTTCCGTAAAAATCTCTGTAGAATT +CCGCATCGGTCAACGATTCTTCACAAGAGCCAAACTCGGCGAGTCGGTCA +AACAAATGTTTGAGCTCCTGAAGAGTAGTTCAAAATTATATATGAATTGA +TTTATCTTGCAAACCTTTCTCCGTTTGTCGGTAAAAAGTCCTTCGGGGCA +GATTTCCGTATCAATCAGACGATTTGCAATGTATACAATCCACATGAGAT +TTGTTCGCCTTGAGAATTTCTCCCAGTTGCCCCTGGAACGTTAATTTTTC +TGAATTTCTAGAAAGGATATAGAAATAGCAACAAAAAAAAAAATTTATCC +AAATAATGAGCTATTTAATGTAGTTTATATTACTACAAATACTTTTCTCA +TAAGAACGTCTTGTTCTTGATAAATGTGTGCTTTAAGAAAAAAAAAAGTC +AAAAATAGAGTCCTGAGATGTCGGGCGTTGTACCTATTAGGGGTGTCAAT +AAGTTCCGGGTCAAAATTCATAACTTTTTTCGTAGCAAATCGATTTTCTT +GAAAATGTGGGAATTTATGTTATCAAACATGGTCTTTCATTTGACGGCAC +TTTCAAAAAGTTTTGACCACTCCATGTACCCTAGCTCGGATCCACTTTTT +TCAGGCGTATGCCCGATCTCGCTTCTTTGTAACTTTCAATTGAGACTTAT +GTGCGGATTTTGATTTATTAAGTATACAATGTAAGAATACAATAAAAATT +TGAGAAAAAATTCGTTCAAAAAAACAATTTTTTTGATCGGCAAAAAACCC +TCGAAAAAAATTTTGTCGAAAACTCTTGATTTTTTGTACAGGAATGATGC +AACCAATTCTGAACAATTTTTTAACACATAAAAGTTTTGAATTTAAGGCG +TCACACACAAGCGGCAATGGAAAAAATGATTTTTTAGTGAATTTTTTGAA +ATTTTTGAGAAATTCTCGAAATCTAAATATTAAATTCAAATGTTTTGTGT +GTTGAAAAATTGTTCAGAATTGGTTGCATCACTCCTGTACAAAAAATCCA +GAATTTCCGACAAAAATTTTTCCGAGGATTTTTTTGACGAACCAAAAAAA +TTTGTTTTTTTGAAGGAATTTTTTCTCAAATTTTTATTGTATTCTTACAT +TGTATACTTAATAATTCAAAATCCGCACATAAGTATCAATTTAAAGTTTC +AAAGAAGCAAGATCGGGCATACGCCTGAAAAAAGTAGATCCGAGCTAGGG +TACATGGAGTGGTCAAAACTTTTTGAAAGTGCCGTCAAATGAAAGACCAT +GTTTGATAACATAAATTCCCACACTTTTAGAAAAATCGATCAGCCACGAA +AAAAGTTATGAATTTTGACCGGTAACTTATTGTGCTACATGCTTGTTGCG +AAATATACCTATTTACCTATACCTATACCTATACCTGCAATTTTCTCTCA +TCTCTCGATATACTTCAAATTGTGGAGCATCTGGTCCTTCAAAAATCGTC +GTATCCTCTTCCAAATCCCAGTAGATAGTTGTCGAATCTAAAATTATATA +TTTTTAATTATAAATTGTATATTTTTTTAATTTAAAAAATAACAAACCTT +TCGAAATGCGGCTAAGTGTGAAATCAATAATATTGACCTTAATTCCATGG +GTCCTCAGTGGAATTTTCTGCCCATGCACAGTGTAGGAGAGCTCTTCCAC +TCCGTTCCGATCGATCAGCACATTACTAAGATTTAAGTCCCTGTGCTCGA +ATTCAAGAGCTGCTTCAGCTGCAACCATTGAGAGAACGAGCTGGTGAATG +ATGGAAAATAGTTCATCTTCACTTTCAAGGACAAAATCTGCCAGCGAGAT +TCCACCATTTGCCGAGACGAAAAGGATAAAGTTTTGATGTTCTGAAGAAT +AAACATCTGGCCTCAAATGTTCGGATTCATTGAGCTTATCGTAGGCATCC +CAAGCTCTCAGTAATCCCTTAGGATATTCCCCCATGACTATTTGGGCTGA +AATCATTTCGATAAAATTCGGCGTAGAATTCCAAGAATTTGGGTCTCTCA +ACGCCGACAGTTCCTTCATCACAATCACCTCTGACAAAACGGCGTGGGTT +GTTGGAATTTCCACGGATTGATTTCCATAGAAACATCCGTTGTTTTCGAA +TGGCAAAACTTTGATAGCAACCGGTCTACCATTCCAGACAGTTGAGAAGA +CTTCACCGTACGCTCCTTCGCCGAGCTTCTTCACTTTTCGAGCATCTAGC +GCCGACGTTGGTAGGCTACCCCATGGTTTTGCTTCTTTTTGGCCAACAAC +ACGGAGAAGTTGTGCCATGGACGGATCTTTATTGTGAAATGTGATACTGC +CAATGGGGATATTTCTAGAATCAGGATGAGCTGACCGAGCACTTGGAGCT +CTTTTGTTCAGTTCAGCAAGCATGCACAGTTCGAAAGCATGCACAGTGCG +AAAATGACTTTTCTGAAATTGTCATCAAAAGTTCATTTTGAAAATTCGTT +TCGGCAAAAAATGCAAATGCATTTCTGAAACTCACCAGTTGTCTCTGAAA +TCGTCGTTCGTTGGTCATGTCGAGTGCAAGAACGGTGGTGGTGACCACTG +CCGTCTTCGTGAACCGCATCCAAGACATGTTTCGGGAGATAACTATAGAA +ATGAAGTTTTGAAAAAAAAACTCAAGACCACAATTATTGAAACACGTTAT +TAGGCCAATAACTTCACACGTGAATTAATACATTATTCATGTATTTTTCT +TTGACTGTTATCACGGGTTTCTGGCTCACGGTAGTTCAGCCACGGTAGCA +CAGAAAATAGATGACCACGTTCATGATAATCAGTCTGAAACCTATATTGG +CTGCTATCTCGAAAACTCTCTAAAAACGCGTTTTGAGAAATTATTGATTT +TTTGGAGAAAATCAGAAATTATTGATTTTTTGGAGAAAATGGGAAATTTT +TCATTTTTATTGGGGAAAATCAGAAATTATTGATTTTTGGAGAAAATCAA +AAATTATTGGTAATTTGAAGCAGGGGTGGGCAGCAATTGCCGTTCGGCAA +ATACGCAAATTACCGGTGTGCCGATTTTCCGGGAATTTTCATTTTCGGCA +GTTTGCCGGTTTGCCGATTTGCCCGACATTTTTCAATTTCGGCAATTTGC +CGGTTTGGCGATTTGCCCGAAATTTTTCAATTTCGGCAATTTGCCGGTTT +GCCGATTTGCCCGACATTTTTCATTTTCGGCAATTTGCCGGTTTGCCGAT +TTGCCCGAAATTTTTCAATTTCGGCAATTTGCCGGTGTGCCGATTTGCCA +AAAATTTTCATTTTCGGCAATTTGCCGGTTTGCCGATTTGCCGGAAATTT +TCATTTTCGGCAATTCGCCGGTTTGCCGATTTGCCCGAAATTTTTCAATT +TCGGCAATTTGCCGGTTTGCCGATTTGCCGGAATATTTCATTTTCGGCAA +TTTGCCGGTTTGCCGATTTGCCCGAAGTTTTTCAATTTCGGCAATTTGCC +GGTTTGCCGATTTGTCGAAATTTTTCATTTTCGGCAGTTTGCCGGTTTGC +CGATTTGCCCGAAATTTTTCAATTTCGGCAGTTTGCCGGTTTGCCGATTA +GCCCGAAATTTTTAAATTTCGGCAATTTGCCGGTTTGCTGATTTGCCAGA +AATTTTTCAATTTCAGCAATTTGTCGATTTGCCATTTGCCGGAAGTGTTC +AGAAGGATTTTTTTATAATAAGGAACCACTTAAAACTGTGCCGTTTTGAA +ACTTTTCCCCGTTTTTTTAAGATGATTTCATAGAATTTGCTTACTTGGTT +TGCCGAATTGCCAGAAGTTTTTCAATTCCTACAAGTTGCCAATTTGCCGG +AAACTTTTTAATTATGGCAATTTGCCGGTTTGCCGATTTGCCAGAAATTT +TTCAAATTCGGCAATTTGCCGGTTTTCCGATTTGCCGGAAATTTTTCAAT +TTCGGCAATTTGTCGATTTGCCGGAAAATTTTTATTTATGGCAATTTGCC +GATTTGCCGGAAAAAAAATCGTTTCCCGCCCACCCATCAGTTGATGAGTT +CATCTTTTTTTTGTGTCTCTCCCATCAATCTTAAACTCGACCCGGACTGG +CAAACGCATATCTACAGTTTTCTCTTCTTAAAATGGTGGTCTTAAGTTTC +GAAGACTATGCGTAATTTCTAGCGAAGTGGCGAATTTATGATGATTTTGC +AATTTATCAATGAAAAAAACAAAAAAAGCATTTCCGCGTGGCAAATTATC +ACTGTTGTGCCGCGAATAGTACTGATATAATTTTTTTTTAAATTGAATCA +GTTTGGAATTTCGAATTTTTGAAACAACCGCCGGCAAAATGAATAATATA +CTGTGAGTTTTCAAAGATTGTTCCCCGGTTTTCTTGTAGATTTTTGTGCA +ATTTCAAAATTTCGACTTTCAGCGGAAACAAAAATACAAAAAGGTCGAAG +AAGAAGGACGGAAAGTTTACGAGCAACACTGCTACTGATCTTGTTGAGGC +CCCAAAACCAGGTGGAGCAAAAGGATCCAAAAAACCAAAACCATCGAAAG +GAAATGACGACAGGGGACGCGGCGAACCGGAAATGACTGCACAATCCAAA +AAAACCAAGAAAGCAAAAAAAGTGAGACAGAAGAGAGATACAAAGGCACC +GGTGAGTTCAATTTTATAGTTTTATAGATATAATTGTATCAGGGGTGGGC +GGCAATTGCCGTTCGGCAAATTGATTTGCCGCCAAATTCGGCAAATCGGC +AAATTGCCGGTTTGTCGATTTGCCGGAAATTTTCAATTCCGGCAATTTGC +CGGTTTGCCGATTTGCCGGAAATTTTCATTTTCGGCAAATCAGTTTTGCC +GGAAATTATAAGACGGAAACACTGTCTTTTTGAATTGTTCCCGTTTTTTC +TACATATTTTCATAGAAATTCATAGAGACAATTTGCCGAAATTTTTCGGC +AAATTGCCGTTTTTCCGGCAATTTACCGATTTGCCGGAAATTTCCATTCC +GACAATTTGCCGATATGCCAATTTGCCGGAAAAAATCGTTTGCCGCCCAC +CCCTGAATTGTATCCCTTTTTAGTCTCCTGCAATGTCACCTCGATCACGT +GAAATGCTGTCAGACAACAAAAAGACGACCGTTGAGGATGATCCAGCAGT +TCCAATAACAACAAGTGTCGCTGGAGCAGTCACTTCTACGATTCCTGCTC +TCATGTCCACTGAAAACGCGTTTCAGCCACCCAAAGACCTTATCTCGGGA +AGAAAGCCAAAAGGTGCTCCGAACTTGTCTGGCAGCGTTCCACTTTCACA +CAAGAGCTCACTGACTGGAGGTGCAGATAAGTGGGTTGGAGAAGCCGTGG +CAAAGAATTGGATGGATTCGATCGGTTAGCATCCTTTTTTTTTTGATTGG +AGGCCCCGGCGGCGTAAAAATCGTGCCAGAGTTGCAAGAGTGGGCGTTTT +TTTTTGTTTTTCTGTTGTTGGTGGGGCCTTATTATTATTTGGTCGATGGT +GATTTTACTTTACTGGTGGAAATCCGCTAATAAAACTAAAAACATCGGGA +TATAAATAAAAACCCAACTTTAAAAAGCGAACCAATCAGCAGTTTGCTCC +GCCCACTATTCAACCAATCCAATGATTGGTTCGAAATTGGGTACTCATTT +TAGAGGGAATTCAAACGGAAGATTAGCAAGTTCGGTTATTGTTTCATTAG +AATATCATTGCTTATATATATATTTAAAAAATAGTGTACGTCATCAATGG +GCGGAGCCTCTCCCATCGTGGTGAGACCCATCGTGGTGAGACACATCGTG +GTGAGACCCATCGTGGTGAGACCCTTCGTGGTGAGACCCTTCGTGGTGAG +ACCCATAGTGGTGAGACCCATCGAGGTGAGACCCTTCGTGGTGAGACCCA +TCGTGGTGAGACCCATCGAGGTGAGACCCTTCGTGGTGAGACCCATCGTG +GTGAGACCCCCATTAATTTTGGCGTGAAATTCAAATTTTCTAAGAACAAT +TTTTTGGCTTTTTTTTTAAAGAAAAATCTGGAAAATTCTAGCATTTTTTT +AGAATAATCTGGAAATTTCTTGAACTTTCTAGCTAAATCTGGAAACTTCT +AGAATTTCCTAAAATAATCTGGAGACTTCTAAAAAAGATCAGGAAATTTC +TAGAACTTTTTTAGAATCTTCTGAAAACATCTTTCTAGAGTATACTAAAA +ACTTCTAGAATTTTCATAAAATTCCGCGAAGCTCGAGGAAGAGATTTGTT +CAAACAATTTAATGTGGAGCCAGTCGGAGCACGCGCTTTGCGCGTGCGAA +CGGCTGGTTTTAGATATTTTGTAGTATTTTTCAAATCTTAAATTTTCAGA +CACAGCAGAGGTGAAAAAGGAATACGATAAACTGCAATCACAGAAAATCG +ATGTGGAGAAGGACTGTAAAACCTGGAAATCCAACCCAAAATTTAACCAA +TCGGAAGACTTTCCTGCCTTGGACTCCAATCTCGTGAAACTTGGCAAAGA +CTATGTGAACATCAGTCTTGTAGATGTTCCATTGGGAAGAAATGTTCATC +TCGGTCAAGCTCCGGTCACGAATACGGAAGAAACATTCTGGAAAGCTGTG +TTCGACAAGCGAATCACTCACATTGATCTACTCGTCGGCGATGAAACCAT +CGAATTCTTCCCTAAAAAGGCAGAAGATTATACAAATTATGGTCAGATGT +GGATCAATAACCGCCGTGTCGAGTATGTCAATGACGATGTGTACCGATTT +GCAATTGAAGTAGTGCCCCACGGATGCTCCAACTCGATCATCTGCAATGT +GACTGTTATCAGCAATTGGAAAGTGGACACTGTGCCTTTGAAACAAGCAA +TCGCCATCAAAGAGGCACTTGGTCTAAACTACTTCTTGCTGAAAGCACCC +GCTGACGAGCATGCGATGATCGTCTCACCACGTGGAGCTGGACGAGCTGG +CTACTTTTTGGCACTTGCGGTTGCAGTCAACACAATTGATACAAAGCTTG +CCGAACCATGTATTGCGGATATTGTCAAATCGATTCGCTCCCAGAGACCA +AGAGCCGTGGATTCATTTTGTCAGTACTGCTCCCTGTACATTTCGTTGCT +CTACTTCATCAAGGTATTGGTTTTTGAATTCTTGTAAAATGAGAGAATAA +TTCTCAAATTTACAGAAGAAAGTGACAAAACCAGCAGAAGGGGATAAAAA +GCCAACACTGAGCAACAAATACATCTACAAGAAGTCGGTTGAGTTGACCA +AGCAATTCACCGTTCTCCTTCTCGAAGCGAGTCAGCAAAGTGTGATGGGA +CCTGGATAGTTCTTCTCCATTTTGAATATGGAAAAGCATTTGAAGTGATC +TGGGTTTGAAAATGAAGAATTTTATAAACCCTGGATTATTTCCGAAATCT +TGCTTCCTGCCTGCTGTCTCATTGCGGCTTGATCTGCAAAAAAAGCGGTA +ATATCTCCCCCAGGAAAATGTGACGTCAGCACACTCTTAACCATGCGAAC +TTAGTTGAAACGTCTGCGTCTCTTCTCCCGCATTTTTCGAAGATCACACC +AAAATGGGATACTTTGACAACACGTGCCTGCCATCGCTTCCTGACCGGGG +ATTTTGTTAGAAAATTCGTGGAAAATAGGAAGAAACATTTCGAGAAAATG +GAATTATTGATTTTCTGATTTTCTCAAACAAAAAAAAATTAAAATCGATT +GATTTCTGGCTTACCTTACCTAAATTGAAATGGAAGAGTTTGCCGAACTA +GGCCATTTTGGCTCGGCTATATCTGGGGTATATTTACGGCGCGTTGCGTG +TCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAAATGTGATTTGTCCGTG +TGGAGTACACGACTTTCACATGCGTTGTGCGGCGGGCGATTGTCAATGGA +GCGCGAAAAATACAATGAGGAAGGCCAAAACCCCGTGTATTGATTTTTCG +AAAATTTCGGAAAAATCTCTTTGTTTTATTCATTATATTTCTCCTAATTT +CTTTGAAATGTTCAAAAAATCTGATTTTCTTTTTTTTCCCGAATTTTTGA +AAAATCGATATTTGCTATCCATATTTCTCGAAAAGAAAATCGATTTATTA +ATTTTTTTCCGGTTTCCTGGAAGCTAATCAATTCAGAAAAAAGAATTAAG +CTATGAATATATACTTATAAAAGTCGTAAAAGGTATGGAAATATAAATTA +TTTTAAAACAGCGATTTCTGACTGAAGCATCTCAACTACCAGGGCCTCAA +GTTCTTCTTATCCGACAAATGAGACGAGTCGGAGCTATAATTGTGCCGAT +ATTTTCCGGGCGCCGTCTCTTCGAACTCGGATACGGTAGCCTGCCCGACG +TATTTGAAATCGCCCATTAGCACTTCGTGGCAAGCGCCGATTGATGCTCC +GTGGCCGACGAGTAGGAGGTTTCCTGAAAGAAAATCGATAATTTGCGGCG +TGTTTTTATTGATTTTTATGTGAAAATTGGCAAATTATTGATTTTTCGGC +TGAAATCATAAATTACTGATTTTCTGTTAAAATCAGTAATTTATTGATTT +CTTCGGCTAAAATCAGAAATTATCGATTTTTCTGTGAAAATCTGAAATTA +TTGATTTTTCTGCGAAAATCAGAAATTTACGTAGTTTCGCAAAAATTACC +TTCATATTTCTCGAAAATCGCCCGCAGGGTCTTTCCGACACGTGGCACAC +ACGCGTCATCTCCACATCCTTCGCGGGGTAGTGTGTACTGAAAAAAAAGT +TCGGTAATTTTTCTAGGTCTCGCAGCGATTGCCGCCACCGGTATATTTTC +ATTTTTCCAACTATAGCGCCAGCACCGGCGCCGGCATCTTTTTATTTTTC +CACGTAGCACGTCGGCGCCGGCAGCCGCGCAAACTATTTTCGCCGCCGCC +GGCATCTTTTTATTTTCCACATAGCGTGCCAGCGGCGCCGCCGGCATATT +TTTATTTTTCCACGTAGCACGTCGGCGCCGGCAGCCGCGCAAACTATTTT +CGCCGCCGCCGGCATTTTTTACTTTTCCACGTAGCGCGCCAGCGGCGCCG +CCGGCATGTTTTTATTTTTCCACGTAGCGCGCTAGCGCCGCCCCCGGCAT +CTTTTCATTTTTCCACGTAGCGCGCCAGCGCCGGCAGCCGCGCAAACTAT +TTTTCGCCGCCGCCGGCATCTTTTTATTTTCCACATAGCGTGCCAGCGGC +GCCGCCGGCATATTTTTATTTTTCCACGTAGCGCGCTAGCGCCGCCGCCG +GAATTCATTCATTTTTCCACATAGCGTGCCAGCGGCGCCGCCGGCATCTT +TTTATTTTTCCACGTAGGGCTCTAGCGCCGGCGGCATTTTTCATCTTTTC +ATGCAGTGCGCCAGCGCCGCCGCCGGCATCTTCTCATTTTCCACGTAGCG +CGCTAGCGCCGGCGGCAGCGCAAACCATTTTTCGCCGCCGCCGGCGCCTT +TTCATTTTTTAATTAGTGCGCCAGCGCCGCCGCCGGCATCTTTTGATTTT +TCCACGCAGTGCGCCAGCGCCGGCAACGGCGCAATTCTAATCTCGGTCTT +TTTTGAGCGATACCTTCGAGAAAACAGGAATATAGTCCAAATCAACAAGC +GGAAATTTCTCAGCTAGTTTGTCGGTTTCCCAGAATCCAGGAGGCTTATC +ACAAAGATAAAGTGCCTCACAAAGGCCACCGTCCGCCTTCACTTTCATTC +CTTTATCCTCAATAATCGTCGAAGCTGTCTCAATTGTCCGATCGAACGGC +GAGGCAAACGTATGCGAGATTTGTGCATTTTCGAACCGATTTTTGCACTC +TTTCGCCTGTTGCCGACCGCGCACGCTGAGCATCGAATTGTCCGACGTGA +GACCGTCGGCTCCGTCGAGTTTACGCCAATTTCGATTGATATTGTCCTCG +CTGCAATGCAAAAAATCAATAATTTCTGATTTTCACCGTAAAATCAATAA +TTTCTGATTTTTGTTGAAAAATCATTACTACCGATTTTAACTGAAAAATC +AATAAATTCAGATTTTCATTTTTTTTTTCGAAAAGTCGATAATTTCCAGA +TTTTCATCGAAAAATCAATAATTTGTGATTTTCACAAAAAATCAATAATT +TCAGATTTTTACCGAAAAATTGATAATTTCAGATTTTCACCGAAAAATCA +GAAATTATTGACTTTGGATAAAAATCAATAATTTACTGATTTTCATCGAA +AAATCAATAATTTCAACCTTTCGCAGAAAAATCGATAATTTTTAATTTTC +ACCGTAAAATCAATAATTTCTGATTTTCACCAAAAATTAATAATTTTAAT +TTTTTTTTCGAAAAATCAATATTTTCTAATTTTTATCGGAAAATCAATAA +TTTCCGATTTTCACCAAAAAATCAATAATTTCAGATTTTTATCGAAAAGT +CAATAATTTACGAATTTGACAAGAAAAAATCAATAATTTGCTGATTTTAA +CAGAAAATCAATAATTTTTGTTTTTCATTGTTTTTTTTTTCGAAAAATCA +GTACTTTTTTAATTTCCCCAAAAAATCAATAATTTTTGATTTTATTTTTC +GAAAAATCAATAATTTCAGATTTTAACCGAAAAAATCAATAAATTCAAAA +AATTTCATTTTTTTTTTGAATTCTTAAAAGTACCGTTCCGCGTGTCGAAC +AATCCAAATTTTCCGTGGATAAGTGATCGGCATCCTATCGAGATCGGTTT +TAGCTGAAAAAAAACCTTAAAAAATTGGAAAATTGTGTACTCCTCTCGGA +CACGTGGTGTCAGGCTCTCCCATTACGGCTTGATCTACAAAAAATGCGGG +ATTTTTCGTTCTTAACCATACGAAATAAGTTGAGAACTCTGCGTCTCTTT +TCCCGCATTTTTTGTAGATCAACGTAGATCAGACCAAAATGAGGCACACT +GAATGAAGACACCAGGATTTTTCGAAAAACTCTAAAGAAATTCTGCAAAA +AGTGACGTCATGAGGTATATAGGTATGAAATCGAATACTTGGTATCAAAT +GACGGAAAAATAAACGAAAGTTGCAAAATTTTTTGATGGAATTTATTAGA +CTTTGGCGGGAAAACAGATCAAATTTACATTAAAAAATACGGGAAAAATA +CGGGGAAAAAAACCAAATTATTGCCTAAAAAATTCAGGATTAAATTGCGA +GTTGTACTTTTTCTTCTTTCCACGCTTCTCCTCCGAATCCTCGGCGGCTT +TTCGTTTCTGCAGCAGCTCAATTTCCTCGGGATGTAGCAAAGCATGGGCT +CTCGCTTTCTCGACTCGTTCCCGTTTCAGACGCTCGTCTCGCATGCTCGC +CAGCTTCTGCCGTCGTTCTCGATCGTATTCCTCTTCGAGTTGACGTTCTT +CAGAGCTATCACGGTGGCGGTGCTTTTCTGGAAGAAAAATTGGGGGGTTT +TTTTGTAGTTTGTAGTGGTGAGCACCCTATATTGGAGGCGCGAAAAAAGA +GATTTTTCGAATTTTTTTGTAGATCAACGTATGGTTAAGAACGTACTGAC +GTCATATAATTTTGGGCGAAAAATTCCCGCATTTTTGGTAGATCAAACCG +TAGTTGGACAAAAAGCAGATTTTTCGAAAAAAAATTACGAATTTCTGGCT +TTCCTCATAAATTGAAATGGAAGAGTTTTTGCCGAACTAGGCCATTTTGG +CTCGGCCATATCTGGGGTAGATTTACGGCGCGTTGCGTGTCGCGTCGCGG +CTCGATTTTAGTTGTAAAACTAAATGTGATTTGTCCGTGTGGAGTACACG +ACTTTCCCACGCGTTGTCCGGCAGGCGATTGTCAATGGAGCGCGAAAAAT +TCAATGAGGAAGGCCAGAACCCCGTGGTGGTTCGATGCACAAAACTGATT +TTTTTTTTGAATTTTTGGGATTGCGCAAGAAATTTCGCCGAAAAAGTCGA +TAACTCAAAAAATTCTAAAAAATTTGGATAATCTGGAGAAAAAACCCAAA +ATTTGCTGAAAATTTCGAAAAATTTAGCTTTAAATTTTTGCGCATGGCCG +CCGGAAAAGAAAAAAACTCGGCCACCAATTTTTTGGCGGCCATGATGCAA +GACACCATATTTGACGCGCAAAAAAAGGTGTTTTTGGATGTTTTTTTCTT +TTTCCGCCAGAATTTTTAATAAATTTCCAGGGACAAAAAATCATAACCTG +TTGCAAAAATGTTTTTTTTTTCGAAAAATTCAATTTTGCGCGTCAAATGT +GATGCTTTAAGCTCTGTGGCCGCCGAAAAAGAGAAAACTCGGCCACCAAT +TTTTCACTCTCCATTGACAATAGCCTGCTGGACAACGCGTGGAAAAGTGT +CGTGTACTCCACACGGACAAATACATTTAGTTTTACAACTAAAATCGAGC +CGCGACGCGACACGCAACGCGCCGTAAATCTACCCCAGATATGGCCTGGC +CTAGTTCGGCAGAAACTCTTCCATTTCAATTTATGAGGGAAGCCAGAAAT +CCGTGGCCGAAAAAGAGAAAACTCGTCCACCGATTTTTTTTTCTGACGGC +CATGACAAGTTTGCGCGTCTATAATACATCATATTTGACGGGCAAAAAAT +TTTTTAAAGTTTTTTCGAATTTTTGTGATTTTCGAGCAGAAAAAAAAATT +GTCTGAAAATTTATGTGGCCGCGGTAAACTTCGGCCACCGATTTTCGACG +ATTTTGCCCGTGTTTTTGACGGAAAAAGCACCATATTTGACGCGCAAATT +TTCAAAAAAAAAAAAGCCCAAAAATCGCACTTTTCTTCTTCTTCTTGTCT +TTTTTATGCCGTTTCTTCGCCTTTTCTTCACTATCACTATCCTCTCGTTT +CCGCTTCCTCTCCTCTTCCAGCTCTTTCCGCTTCAAACACGGCAGAGCAT +CGCGCGCTTTTCGTCGATCAAGTGGCTCGGCGGCTCTTCGCAGCGGCAGC +TCCTCGTACCACTCTTTTTTCTTGTTTAAATCGTTCGTATTATCCGCGAA +ATACACCTGAATTCCCATTTTCGACTCCCATTCCTTCTTCTCGGCAGCTT +TTTCCGCTTCGTAGTCGCGGTTTCCGGATCCATAGTTTTTTCGTTCTTCA +CGTTCGAGATCCTGCAAAATATCGATTTTTTTTGGAGAAAAATATAGTTT +TTTTTTGGAGAAAATTATCGATTTTTTGGAAAAAATTATCGATTTTTCGG +GGAAAATTAACGATTATTTTAATAGAAAATTATCGATTTTATTTGGGAAA +AAAATCACTGATTTTTTGGAAAAAATTATCGATTTTTTTCGGAGAAAAAA +TATTAAATTTTTTGCAGAAAATTATCGTTTTTTTTTTTGAAAAAAATTAC +CGATTTTTCAGAGAAAAATATCGATTTTTTAGAATAAAATTATGGATTTT +TAAATATAAAATTATCGATTTTTAGGGAGAAAATTATCGATTTTTTTTGG +AGAAAAATATTGTTTTTTTTTGGAGAAAAATATAGATTTTTTTGAAGACA +TTTATCGATTTTTTGTTGATAAAATTATCGATTCTTCGGGGAAAAATATA +GCTTTTTTTGGATGAAATTATCGATTTTTTGGGAGAAAAAATACCGATTT +TTTTGGATAAAATTATCGATTTTTTTGAAGAAAAAGTATCAAATTTTTTG +AAGAAAATTGTCAATTTTTTTGGAAATAAATATAGTTGTTTTGGATAAAA +TTATCGATTTTTCAGCTAAAAATATAGATTTTTTTAGATAAAATTATTGA +ATTTTAAAAAGAAAATTATCGATTTTATGGGTAAAAAATAACGATTTTTT +TGGAGAAAATTATTGATTTCTTCGGGGATAAATATTGATTTTTTCGGGGA +AAATTATCGATTTTTGGATAAAATTATCGATTTTTTGGAAAAAATTATGG +ATTTTTTTTGAAGAAAAATATTGATTTTATTGGAGAATAATATCGAATTT +TTTCGGGAAAATATCGATTTTTTGGAGAAAATTATCGATTTTTTTTGAGA +AAATTATCGATCTTTTGGGTAAAATTATCGATTTTTTGAAGCAATTCTGA +GCCAAATTTTGAATTTTCGAGCGGCAATTTTTGCACAAAGCATCATATTT +GACGCACAAAATTCGAATTTTTCAGAATTAGTTTCACAAAAAATCCATCT +ATCACCTGAAACAAGTTCACATGTCCCGTTTCATCTGAAATGCTGACATC +TTTTGCTGCTCCAGCTGAGCTCGAACCAGCTCCTCCACTAAACATCGTCT +CCATTCGTTGATCGGCTCGGGCTCTCAACTGCATCAGGCGCCGCTCGTTT +TCCGCCTGAATTTGCCTGTCGAGCACACGCTGCTCATCTTCGGCGGCTTT +TCGCTCGTCTCGGCGAACCCGTTCCATGTTGGATTTTGTCCGAACGTGCC +ATGATTTGTGATGGAGAATGTTCATCTGGAAGCGGAAATTATAGAGAAAA +AATTGATAATTGTGCTCGAAATTTGGCTCTGGAAGAAGCGCAAAAAATCA +ATAATTTCGTCCAAAAATCTATTTTTTTCAGAAAAACCAAAAAGCGTTTT +TTTTTCCAAAAATAAAGATAATTTTCGTCCAAAAATCGATAATTTACTTC +TAAAAGTCTCAATTTTTCCAACAAAAAAAACAATTTTCGTCGAAAAACCG +ATGTTTTCAGAAAAATCAAAAATCAAAAAAAAAATTAAAAAATTAAAAAA +AAATCAATAATTTTTTCTAAAATCTTGCAATTTTTTTCTAAAAATCGTTT +AATTTTCTTCTAAAATCGATATTTTTCCGGATTTTTTCGTGAAAAAAATC +GTCAATTTTATTGAAAATTTTGCTAAATTTCGAAAAAAAATCTTGAAATT +TCGATGCACCATGATTTTGAAAATTCTGCTCCGGATCAATTTTTCGAGAA +AAATTATCGATTTTTGGAAACTATCATACAAAAATCGATAATTGTGCTCG +AAATTTGGCTCTGGAAGGAGGAAAAATCAATAATTTTCTTCTAAAAATCG +ATTTTTTTTCCAAAAAATCAATAATTTCGTCGAAAAACCGATGTTTTCAG +AATAATCAAAAAAAAAATTAAAAAATTAAAAAAAAATCAATAATTTTTTC +TAAAATTTTGCAATTTTTTTCTAAAAATCGTTTAATTTTCTTCTAAAATC +GATATTTTTCCGGATTTTTTCGTGAAAAAAATCGTCAATTTTATTGAAAA +TTTTGCTAAATTTCGAAAAAAAATCTTGAAATTTCGATGCACCATGATTT +TGAAAATTCTGCTCCGGATCAATTTTTCGAGAAAAATTATCGATTTTTGG +AAACTATCATACAAAAATCGATAATTGTGCTCGAAATTTGGCTCTGGAAG +GAGGAAAAATCAATAATTTTTTTCTAAAAATCGATTTTTTTTCCAAAAAA +TCAATAATTTCGTCGAAAAACCGATGTTTTCAGAATAATCAAAACAAATT +TCAAAAATAATAAAAAAATCAATAATTTTTTCTAAAATTTTGCAATTTTT +TTCTAAAAATCGTTTAATTTTCTTCTAAAATCGATATTTTTCCGGATTTT +TTCGTGAAAAAAATCGTCAATTTTATTGAAAATTTTGCTAAATTTCGAAA +AAAAATCTTGAAATTTCGATGCACCATGATTTTGAAAATTCTGCTCCGGA +TCAATTTTTCGAGAAAAATTATCGATTTTTGGAAACTATCATACAAAAAT +CGATAATTGTGCTCGAAATTTGGCTCTGGAAGGAGGAAAAATCAATAATT +TTTTTCTAAAAATCGATTTTTTTTCCAAAAAATCAATAATTTCGTCGAAA +AACCGATGTTTTCAGAATAATCAAAACAAATTTCAAAAATAATAAAAAAA +TCAATAATTTTTTCTAAAATTTTGCAATTCTTTTTTCTAAAAATCGATAT +TTTTCCGGATTTTTTTCGTGAAAAAAATCATCAATTTTATTGAAAATTTT +GCTAAATTTCGATAAAAAAACGATTATTTTGAAATTTCGATGCACCATGA +TTTCGAAAATTCTGCTCCGGATCAATTTTTCTAAGAAAATTATCGATTTT +TGGAAATCATCACACAAAAACCGATAATTTTGTGAAAAAATTCGATTTCG +ACGCACCATGATTTCGAAAATTCTCAGAATTTTAGAAAATTTATCGATTT +TGTGTAGAAAAAATTCGAATTCCAGTGGAAAAATTTTCTTTTCTCAAAAA +ATGTTTGATTTAAAAAAAATCGATTTTTTCAGAAATTCAGGCATTTTTTT +GCAAAGTAAATTGGCAAAAATCGATGATTTCACTGTGAGAATGGGAATTT +TTGTCAAGAAAAATATAAAAAATTGCCTTAAACAATTAAAGTGGTTGTCA +AAAAATTGAAATTTTGGAAAAAAAAATATATTTACAGATGAATTTATTAG +AAAAATTCCACAAAAAAAGAGGTTCCATCTAATATTATTATGTCGCATTG +GGGGTTATATCACATAATTTTTTTTTGTTTCGGTTGCCGTGGAGAAGGGG +GAAAATATCACATTTTTCAGAGGAAAATCACAATAAATATAAGGAAAATT +TACAAAAAAAGGCGCGGGGGGAAATTTCTTCACAAAATTATCGATTTTTG +GGTGATAATTTCCAAAAATCGATAATTTTTATAGCAAAATTGATCCGGAG +CAGACTTGGGATAAAGCAATTTTTGGAGGGGGAAAATGAACAAATTAATA +AAATATAATATATTCGGGGCAAAAAATGGGAAATAATTAAATTGTCGGAA +CATATAAATGATTAATTGATTGAGCCAATGGCATTGGTTTCATGTGAGCC +AACGCTTCATTACAGAACACTTCCTCCCGATGACGTAGCGGACGAGAATG +CTCGACACGAGCAAGACGGTAGGCTCTAGAGGCGTTTATCTGGAAATTTT +TAGTGAAAAAATGAAGAAAAAAAGCTTTTTTCGCTGAAAATTCCAAGATT +TTCGGTTTTTTTTTTGCTAATTTTTTTTAAATTTGCCTTGAAATAAATTT +CCAGATGTTCAGTAGTTTTTTTTTCCTTCAAAAATCGATTTTTCAATTAA +TCAAACATTTTTCAGAGTATTAATAATTATTTTTCCACCAGAATTTGAAT +ATTTTATCCAAATTCTGAGAACCGGCTCACAGAGCGGCTTTTACTACGTG +GCCTAGAAAAATCAAAAACTCGGCCAATGATTTATCTGGGATTTTTGACG +TGGGATGTTTCTGAAACTTGACGAGAATGTTCTCGAATGGGGGTTCTATA +GTTCCACCGTGGCGATTTTTGAGAAAATGTTCCGTATCCATGTTATGAAG +GTGGCCGAGTTTTCTTATTTTACGGCCACGTAATAAAAACCGCTCTGTGG +GCTCCTGAGCAGAATTTTCGAAATCATGGTGCATCGAAATTTCAAAATTA +TCGATTTTTTTTTTGAAATTTAGCAAAATTTTCAATAAAATAAGAAATCA +TGGTGCATCGACAAACCAATTTTTTCCATTTTTTCGGAATTTAAAATAAA +ATTTAAAAAAAAGTAAAATTCTGGAATTTTACTTTTTAAAAATATTTTTT +TCAAATTCTGGCAGTTTTAAAATAATAAAAAAACGTTTTTTTTCCATTTT +TTTCAAAAATTTTTTTCTGAAATTTAGTACTACAAATGTAAAATTTACAG +GGTTTTCACAGGAATTTTCAATTTTTTTGATTCGCTTTTCTTCAAAAATT +CTAAATTTTCAGGTTTTTTTTTCCAATAATTTTTAATTTTTGTGAAAAAA +AAATGTTTTTAATTTTTTCAGACTTAAAAAATTGTGACAACTTTTTTCAA +TTTTTTCCGCAAAAATAAATTTTCGGAAATTTCAAATTTCCTACAAAAAA +CCCCTTACCACAGTAAGCCTAACCAACTGTGAGAGCTCGCTCATCGTGAC +TAGGGCTCCGTCGAAAAGCGGCCCAAACTCCAGAGCCGACGCCGTATCGA +CGCGCACTCGAACCATCTGAAAAACCAAATAATGGAAGAGTTTTTTTTCG +GCCAAGCCAGGCTGCCCCATTTGATCTACGTAGATCTACAAAAATTGCGG +GAGAAGAAAAAAGAGACGCAGAGTTCTCAACTGATTTCGCATGATTAGGA +GTGTGTTGACGTCACATTCGCAAAAAATTCCCGCATTTTTTGTAGATCAA +ACTGTAATGGGACAGCCTGGGACCACGTGCAGTGTTAGGCTGTACCATTA +CGGTTTGATCTACAAAAAATGCGGGAATTTTTTGCAAATGTGACGTCAAC +ACACTCCTAATCATGCGAAATCAGTTGAGAACTCTGCGTCTCTTTTTCTT +CTCCTGCATTTTTGTAGATCAACGTAGATCAAGCCTCTCTCTCTCTCTCA +CCTTATCACCGACTTGCTCCAACACAATCAGAACATCACAAAACTTGGTG +GCAATCGTTTCGCGGGTGTACACTTTCCGTGTGTTCTCAGTCCACACCAC +ATGCACCTCATCGTTTCCGATATGCTTCCACTTCTGCTGCACATCGCCGT +TGAGCATCGTGCTCACATGGAATATCACCTCAGCCTCGGCGTCTGCAAAG +TACGGAGCCCGTGTCTCTACGGGCAGGCCACCGGTGTAACCATCGTGTCC +TCGACCCACTTTGACCTCCCATCCGAGCTCCGACGTGAAGCTGTCAAATT +GCGCGGAGGCGGAGGCGGTGGTGTTGGACAGGATCGATGCTCGATCTTCC +TGCGATTCTCCTACATAGATCACAGCGACTTTGTGGACTTCACGAGAAGA +AGTCTGATCTAAATGCTTCAAGTCACGCGGGAAATTCGCGTGAACCTGAG +ACACAAGTGGGACGAATCCCAGGGAAGCCGACAGCGATCTCCATTCGAGA +AGCTTCGCGTTCGGAGTGAACGCTGGCAAATGATCGTGAGCCGCCGACGA +TGTGCCAAGTGGCTGTGGCTGCCGTCTAGACGTCTCAATCATCGATGTAA +ACTGTGCGGCACCATCGACAGGCGACGGGCTCCCACGTGACGGGGGGTAG +TCCGGTAGATCATCGAACGGATCATCCATCGCTCCGAGGATCCCCTGGCT +TTCCCGACCGGGACGTTTTCCCTTGAGAGCCTCTTTGCGTAGCCAATTGG +TCACGTTGGTGGCAGGCTTGCGGACATCCTCATGGGTATCTAGATCCCAG +ATATGCCGGCCAACTACCGTTCGGGAAGTGATTTCGCAGGGGGATTTGGC +GTGGAAATCCTTTCGGGACACCGAGATAATCGCCGATTGCCGATTAATAT +ACACGGTTTTATCCTCTCCTTGTAGTGGCGGTGCTCCTGCAGAGCTCCAT +CTCTGAACCTCAAAACCTCGCACCGGATACTGACCACCGAGCGTGACAAG +CTCTCCATGGAGCACCATATGCCTATCGGCCAAGATACCGCGAATGACGA +GTGGCATTTGAGGTTGTGGCCATTGCATACAAAGCTTCACCATCTGCCAC +TCGATCTCGGTTCTCGTACGCTCATCGCGTAGGAGCGAGGCGGCACGGAG +CAGCGCCTGGAGCAGTGTGGTGCTCGAGAACTGGGCGAGCGAGGCGATCG +ACGAGCAGAAGAGCGGAATGAGCCGCATCGCGAACTGATGGGTTTCGATG +GTTTTCAACGCGGTGAGCACCAAGTCGATTTGGGCTTTTTGCACGATGAG +GATGGCTAGCGAGTTCACGATTACTACGGCGTTCTCCGATACGTCTGTAT +TGACAAGCTGATCGAGAAGGATTTGCTCGGCTCCAGGATACGATGAAGCT +AGCATTGAGAACAACTTCAACGAGTTCGAGGACACCTTCGTGTCCTTCGA +GCTCTTCGCCGCCTGCAACATTTTCGGCAAATGCTCCAGAGCTCGCGGAG +CAACAATTGATAGTTCGTGTGCAGAGAGCCCACAAATCGCCGGAACCACT +AGTTGCTCCTTGGATTGCATAAGACGGATGAAGCAGAGAAGAATGTTGGC +CGAGAGCAGTGGCGGTGGCCGACGGATCGTTGATTCGTTGAGAATTGCAC +TTAGAGCCGGAACACAGCGGGGCAGCAGGATTGGGGGTACGGTAACGAGG +CGGCACGCGAGCCAGTGGGCCAGTGGGTGCAGGTTTACCTGGAAAGCAAA +ATTTTTTTTGGCTTTTTTTCAACTCGAATTTTTTTTCTAAATTTTTTTGT +AAATTTTCTAAAAAATAATTGTTCGATTTCAGAGTGCCTCATTTCGTGCG +TGATCTACGTTGATCAACAAAAAATGCGGGACTGATTCTGCATGGTTAAG +AACGTGCCGACGTCCTATTTTTTGGGCAAAAAATTCCCGCATTTTTTGTA +GATCAAACCGTAATGAGACAGCCTCACGTCGTGCCAGAAAGTCCCATTTC +GTGCTTGATCTACGCTGATCTACAAAAAATGAGGGGCTGATTGTGCATGA +TTAAGAACGTGCTGACGTCACATTTCGTTTGGCAAAAATTCCCCCATTTT +TTGTAGATCAAACCGTAATGGGACAGCCTGACACCACGTGATCTTCAAAT +TCCCGCCAGCCTGAAACCCACCAAAAGCAAGTTCTCAATCGTCAATGACA +TGCAATCGATTGCCACGTGGGCACTCGAGTTGGTATACGGATCCACGAGT +GAGATGACACGACGCCACGTTTGAAGCCACGCCAATTTGTCGCCAGACCA +AGACTGAAAAAGGGAAAAAGTGTGATATGCGCCTTTAAGAAAGGGTTACT +ATAGTTGTCAACAACAGAAAAAAATGCTGAAAAGGCATTTTTCAGGGTCT +ATTTTCACAATGAGTTTGGGTATAAATTGGAGAGTTTTCCATAGATAATG +CGTACTGCGCAACTAATTTGACGCGCAAAATATCTCGTAGCGAAAACTAC +AGTAATTTTTTAAATTACTACTGTAGCGCGCTGGTGTCGATTTACGGAAA +TTAATTAAAATAATTGATAAACAAAACAGAAACTATGTTCAAAAATCGAG +ATCCCGTAAATCGACACAATCGCTACAGTAGTAATTTAAAAATTACTGTA +GTTTTCGCTACGAGATATTTTGCGCGTCAAGTATGCTAAAAAATATGTAG +TTGTGGGAGCCTTGTGAATTTTTAGAAGGTTTTTTGAAAAATAACTCGCC +ACTATTAAAAAAAATATATATTTTGAGGCATTTTCAAAGGGTTAAAGTAA +TTTTTTACTTTTAAAATCGTTTTTTTTTATAAAATAAATTTTAAGCGTTT +TTAGTACAATTTTCGTAAGTTTTTCGTTTTTTTTTTGGTCATATTTTGTA +GTTTTTTACACTATTTTCCAGAAATCGTCAGAAAAAGCACTTAGAAACGG +GCTAGAAAAACGGGGTTTCGGCTTGCTGCGAAACTTTTTTTTTTGAAATT +ACCGCGCAAAAATAAATTGTCATTCAAGTAATGTTGCAAAATGTATTAAA +ATATAGGTTTTTAAAAATGTATTTTAATACAGTTGTGACGTAATTTTTCT +ATTTCAATTTTTGCAAAATAAGAAAAAAAATGAATGTAAAAAAGTTAGAA +AGTTTTTAAAACACATTTTATACAGGTCATTACGCTCTATTTTCTGCCAT +TTAAAGCGAGAATGTTTTTTGACACTACATATATAATATTAGGTCTCCAA +ATAAGATCCGGGTCAAAAATCATAACTTTGTTCGCTGTGTATCGATTTTT +ATGAAATTGTGGGAATTTGTGTTATCAACCATGATCTTTCATTTGACAAT +AGTCACAAAATTTTTTGGCCGTCCGAAGTGCCCGTACTCGGAGCCAATTT +TTTCAGACATTTTTCAGATCTCGCTTCTTTTCAGGTTTCAACTGAGGTTT +GTGTGCGGATATTGCTTAGTTTAGTACACAATGTAAGAAAACAAAAAAGT +TTGGAAAAAAATCCGTCCAAAAAAAATTTTTTTGTCGCTCGTCAAAAAAT +CTACAAAAAAAATTTTGTCGAAAATTCTTGAATTTTTATACAAAAATGAT +GTAACCGTGTGCAAACTAATTTTAAACATACAAAACATTTGAGTATGAAA +TTTGGATCTCGAGAAATACTCCAAAAACTCGAAAATAGTTCGAAAAAGCT +GTGTTTTTTGTTATTTTTTTTAGTGTGACGCACCAAATTGAAATTTTTTG +TATGTGTAAAAATAGTTTGCACATGGTTACATCATTTTTGTATAAAAAAT +CGAGAATTTTCGAAAAAAAATTTTTTTGAAGATTTTTTGACAACCGACAA +AAAAAATTTTGTTTGGACGGATTTTTTTCCAAACTTTTTTGTTTTCTTAC +ATTGTGTACTAAACTAAGCACAATCCGCACACAAAGCTCAATTGAAAACT +GAAAAGAAGCGAGATCTGAAAAATGACTGAAAAAACTGGCTCCGAGTTAG +GGCACTTCGGACGGCCAAAAAATTTTGTGACTATTGTCAAATGAAAGATC +ATGGTTGATAACATAAATTCCCAAAGTTTCATAAAAATCGATACACAGCG +AACAAAGTTATGATTTTTGACCCGGATCCTATTTGGAGACCTAATATATA +TATATATATAAAGATACCTACCGTAACCGCATTTGTAATATCATCAGTGT +CATGAAAAACGTTATCCTCTGCAATTGTGTTCGACGATGACATACTATCT +CCAGTCTCTGACGAATCATTTCTCGGGTCTTCCATCATTGCCGATTCGAT +TGCCTGTCGTCGACTGTTCTGTGAGACTTCTGTCGCTTTTCGGAGAGCTT +CTTCACGGGAGAATATGTCGATATGGGCGAGATGGAGGATTAATGCTCGC +GTTACACTGTTCACAATCTGAAGATTTCGTTTTATTTTTTTGATTTTGGC +TGGAATTTCATAAAGCTATGCTTTTGTTGAAATTTTAGTTTAAAAAAATA +AGGTTTTTGAACTGAAAATTGGGATAAGAATTAGAAAAAAATTTGTTTTT +TCTCTAAAACTGCTGCATTTTATTCAATTTTGTAAGATTTTCTGTACAAA +ACATAATAATTTTTGAATTTTTTTTCCAAATTTTTTGAAATTTCAGCAAG +AACTGGACAAAAAGCACTACTTTTACTAAAATTGGCAGCATTTAGGAATT +TCTGAAAAAAACAATTAATTTTCATTATTATTGTCATATTACAGGAACAC +ACTATTCTGAGAATGCGTATTACACAACATATTTGACGCGCAAAATATCT +CGTAGCGAAAATTACAGTAATTCTTTAAAAATGACTACTGTAGCGATTGT +GTCGATTTGCGGGCACGATTTTTTGAAATGAATTTTAATCATATTTTGAG +CAAAAAATGGGTCAAAAATCAAGCCCGTAAATCGACACAATCGCTACAGT +AGTAATTTAAAGAATTACTGTAGTTTTCGCTACGAGATATTTTGCGCGTC +AAATATGTTGTGTAATACGCATTCTCAGAATTTTGTGACTTTTCAAAAAA +AAAAATCGTGATCAAAAAAAATTTTTAATTGTTTTTTAAGATGAAATTAC +GATTTTTTTCGTTCTCTATAAATTTTGATCAAATTTATTTCAAAAAAAAA +AAAAATTCTTTCTATATTTTTTTTTTCGAGTTTTTTTTTCTATCTTCTGT +ACAAAACACAGCAATTTAAAAAAAAGGCAAAATTTTAAGATTTTTCTAAA +TCTAGATTTCTAATTTTCCTCGGGGTTCTGGCCATCATCCTCATAAACAG +AAATGGAAGAGTTTTTGCCGAACTAGGCCATTTTGAAACTCTTCCATTTC +AATTTATGAGGAAGGCCAGAGCCTCGTGGAAAATTAGAAATTAGATTTCG +AAAAATCTTAAAAGTTTGCCAATTTCTTATTAGATTGATGTGTTTTGTAC +AGGAAATTGAGAAAAAAATCGGCAATTTTATACAATTTAATTTTAAAAAA +TATAGTTAAAAATAGAAAAATTCAATGAAACTGGAAAAAAATGTTTACTT +TGAAAAGTTAAAAAAAATGAAAAAAAAACTCAAAAATTGAATAAAATGCG +GCAATTTTTGAAAAAAAAGCTTTTTTCCATAGTTTCTGTCAATTTTCGGC +TAAGATTAATTTTTTTTCATCAAAATTTCGATTTTCATACTCTCTTACCG +AAGCCCATTGCTCAGCCATCGGTATCCAAACACCCTTCTTCATGACGTCA +TGCACCTCATCCCACACCTCATCGTCAATTTCGATGCGTCTGACAGCCTT +AATCACGACGACATTCGAGATGAGTGTCGACGTAAAAGCAGCCGACACAT +TCTGGGAAAACGCGTCCGATTGGCGACAGATTTTCGAGGCGCATGTGCAG +AGTCCCGCCATTAATTCTGACCAGAATTTTTGGGGAAGCGGTTTTGGGAG +TTGAATTCGATGGGAAACCAGCTGCTTGCACGATGTTAGAATCGCAAATG +CTATGGAGATTGCCGAGGAGTGACTGGAAAAATATTTTTTTTTAATTTTT +AAAGGGATTTTGGGAAATCGAAAAATTTAAAAACTCGGATTTATGAAGTT +TTTGGCAAACCGGCAACTTCTGGTTTTTGGAATTTCGCCACTTTTTAACA +ACCGGCAATTTGGCGATTTGCAAATTTTTGGAAAACCGGCAATTTATGGT +TTTTTTTTCGGAATTTTGCTAATATTTTTAAAACCGGCAATTTGCCGATT +TGCAAATTTTTGGAAAACCGGCAATTTGTGGTTTTTGGAACTTGGCCACT +TTTTATAAACCTACAATTTGCCGATTTGCAAATTTTTGGAAAACCGGCAA +TTTCTGGTTTTTTTTTGGAATTTTTCTAAAATTTTAATAAACCGGCAATT +TGCCGATTTGCAAATTTTTGGCAAACCGGCAATTTGTGGTTTTTTTGGAA +TTTTTCTAAAATTTTAATAAACCGGCAATTTGGCGATTTGCAAATTTTTG +GAAAACCGGCAATTTTTGATTTTTGGAATTTTGCTAAAATTTTTAAAAAC +CGGCAATTTGCAAATTTTTGGAAAACCGGCAATTTGTGGTTTTTGGAATT +TTGCCACTTTTTATAAACCGACAATTTGCCGATTTTCAAATTTTTCGGCA +AATTGCAGGTTAATAAAAAGTGGCAAAATTCCAAAAAAAAACCAGAAATT +GCCGGTTTTCCAAAAATTTGAATATCGGCAAATTGTAGGTTTATAAAAAG +TGGCAAAATTCCAAAAAACCACAAAATGCCGGTTTTCCAACTCTTTCAAC +GAGAGTATCCAATTTTTTAAATAGAAAAATTGCCGTATTCCCTACCGTTC +TCCACACATTTGCCGATTTTCAAATTTTTGGAAAACCGGCAATTTTTGAT +TTTTGGAAGTTTGTAAAAATTTTTTAAAGCGGCAATTAGTGGTTTTTGGA +TTTCTGTCACTTTTTATAAACTTACAACTTGCCGATTTCAAATTTTTGGA +AAACCGGCAATTTGTGGTTTTCAAGTTTTCTGCTAATTGGCAAACTGGCA +AAATGCCTTATTTTGGAAGTTTAGGTAAATTCTCAGAACACCGGAATTTT +GACATTTTTCAAAATTCCAAAAACCACAAATTGCCGGTTCGCCAAAAATT +TGCAAATCGGCAAATTGCCGGTTTTTAAAAATTTTTGCAAAATTCCAAAA +AACCACAAATTGGCGGTTTGCCAAATTTGCGAAATTCCTAAAACTGGAAA +TTGACGGTTTTCAAAAAAAAAAAAAGAAGGGAAATCGGCAAATTACAGAC +TTACAAAAAGTGGCAAAGTTGCAAAAGCCAGAAATTGCCGGTGTGCCAAA +TTTGCGAACATTTGAAAATACCACAAATCAAATTGCCGGTTTGCCGAAAA +TGTGCAAATCGGCAAATTGCCGGTTTTTGAAAATTTTTGCAAAACTCCCA +AATTTACAGAAAAAATTCCAAAAATCAAAAATCCGAATTATTCCAGAATT +TTTTCTTCGGAAAAATTAAAAATTGTTCAATTTTCCAACATTTTCAACAA +GCGTATTATCGAAAAAATACAATCGCACAAATTTCTCGTAATTTATTTTT +GATCTACCTTGTTGACTAGGCTCCGCCCCTAATCTTGTTGCTGTTGTTAT +TGTTGTTGTGGCTGTCTAGTTGAAGGAAGGGGCGGAGCCTATTCAACGAG +GTAGATCAAAAATAAATTATGAGAAATTTGTGCGATTGTATTTTTTTTCG +ATAAAATCCAATTTTTTAATGGAAAATTGCCAATTCCCTACCGTTCTCCA +CATTGAGCCAAATACGGACTGTGAAAGAAGCCCAACAAGATATTCGAGAG +CAACAGCGAGCATCGTTCAATCGATACTTCTCCAGACGCTACGAATGGTG +GAATTTCGTACTGCAAAAGCCATGCGGAGAGCACATTTACCACTTTATGA +GTGACATTTGAGCATGCCAATGGGAGTTTCATTGCTTCACGCATTAGTGT +TAATGCTACGTTTGTTGCCTGGAAAAGGACAAAAAAAACTATTTTTTTAA +ATGTAAGTAATTAATTTATTTTTTGAAATCTCTTTAAATGTGGTGTAGTC +GAATATTTTTTCAATTGCTTAATTACCCTCAAAATTGTCTGAAAACACCG +AATTTCATAATGAACTTCTTGAAAACTTCTCAGAAAAAAGTTATGACGCC +TCAAAAAATGGCCTAAAATTGGTTAAAATTTGAAATTTGACCTACTTGCC +AAGCGGCTGGAAACTAGCTTTTTTTTGAAATCACTGTCAAATTTTGAGTA +TTCAATTTAATTATCTTGCGTTTTCAACTCGATTCAGGTATTTTAAAATC +GATAAACGAAGAGATTTTTAAAAATTATTTACCAAATCTCTTCTTCCATC +GATTTAAAAATACATAAATTTAGTTGAAAACGCAAAATAATTAAATTGAA +TACCCAAAACTTGACTGTGATTTCAAAAAAAAGTTAGTTTCCAGCCGCTT +GACAAGTCGGTCAAATTTCAAATTTTAACTAATTTTAGGCCATTTTTTAA +GCCGTCATAACTTTTTTTTTTTGAGAAGTTTTTCAGGAAGTTTCATTATG +AAATTCGGGTGTTTTCAGATAATTTTTAGTATAATAAAGCAATAAAAAAA +ATTCGACTACACCAACTTCAAAAATGTAAGCAATTTTATTTTGAAGGCGG +TTTTCTTTTACTTTTCTAAAAAAAAAATTTATTCAATTTTACGATTTTTT +GCGTAAAAAAACACGGTCAAATTTTTGTTAAATTCGAAAAGGCGTGTCCA +TTACGGTTTGATCTACAAAGAATGCGTGAATTTTTAGCCCAAAAAGTGTG +ACGTCAGCACGAAAATTCTGCGTCTCTTCTCCCGCATTTTTTGTAGACCT +ACGTAGATCAAGCCGAAATGGGAGAGCCTGACACCACGCGCGTGTGCGCC +TTTAAAGTGAGTACTGTAATTTCAAAAATTCCACAACATCGAGAGTTTGA +AACTACAGTACTACTATTTAAAGGCGCACACACTTTTTCGAATTTAACAA +TAAATTGTCGTGTTGAGACCGTATTTAGGGCTCAAAAAAAAAATAATTAT +CTCGTTAGAATATTCGGGAAAGTTGCAGTTTCACTGAAAATTTGAATTTC +CCGCCAAAACGAATTTTCTCCGAAAAATTTGAATTTCCGCCAAAAAATTT +TTTTAAATCAGAAATTTGAATTTCCCGCCAAAATCGTATTTCTCAGAAAA +TTTGAATTTTCGCCAAAAATAAAAAAAAAAATTTTGGCGCGAAATTCAAA +TTTTCTGAAAAAAAAATATTTCGGCGGGAAATTCAAATTTTCTGAGAAAA +TATTTTTTGGCGCAATTTTTCATAGAAATTTAGTTCTTTTGATGTGTAAA +TTTCCAAAAATTTCAACAAAAAATCGCATTTTTCTTATTTTTTCCCCAAA +ATTTTCAAATTTTCTCCTCCAAAACCACGGAACTTTATGCGACGAAAAAA +GCGCATTTCGATACAAAATCAACGATGCATGTGTAGTTTGTAGTGTTGGT +TGTCCTCCAGCCGTTGTGTGAGTTGTTGCCGATGCAATATTATTAATCCA +TCGAATTAGCCAATATCTTGCAATTACCACCGGATCAGCTGTATCCAATG +GTTCACCATTCTCATCGGCTCCTTCCCAGCCACCGAATACATCGACTCCG +TTCGTTTCCAGATCGGTGAAGCATTCGCCCATGTATAGCTTTATTACTCT +GAAAATTGAAGAGTTTTGTACTCCTCTCGGACAATTGGAGGTGATTTTTT +TTTTCGAATTCTTTAAAACAAAAATTTCCCGAAATTGAGCTTTTAAAATT +TTAAAATTTCAAAATTTCAAAATCAAAAAAAAAAAAAAAAACTTTTGTAC +AAAATTTAAAGTGGAGAATTTTTGTATTTTAGACAAATTTTTTAAACATT +TCTAGCAGAGTTGAAAATTTCAGGCAAATCGGCAATTCGCCGAAATTGAA +AATTTCTCATAAATCGGAAATTGCCGAAAATGAAAAATTCCGGCAAGTCG +GCATATTGCCGGAATTGAAAATTCCTTACAAATCGGCAATTTGCCGGAAT +TGAAAATATCCGGCAAATCGGCAATTTGCCGGAGTTGAAAATTTCCGCCA +AATCGGGAATTTGCCGAAATTGAAAATTTCGTATAAATCGCCGATTTGCC +GGAGTTGAAAAATTCTGGCAAATTTGAAAATCGGCAATTTGCCAAAGTTG +AAAAATTCCCGGCAAATCGCCAATTTGCAGATTTTTCGACCGAAATTTGC +CTACCGGCAATTCCTGCCGACCCCTTTTTTCCGAGAAGAATTAACTTTCC +ATTTCTAAAAAATCTGTAATTTGCCGGAGTTGAAAATTTCCGGCAAATGG +GCATTATGCCGAAAATGAAACATTCCGGTAAATCGGCAAATTGCCGAAAA +TGAAAAATTCCGGCAAATCGGCAATTTGCCGAAGTTGATAATTTCCGCCA +AATCGGGAATTTGCCGAAATTGAAAATTTCGTATAAATCGCCGATTTGCC +GGAGTTGAAAAATTCTGGCAAATTTGCAAATCGGCAATTTGCCAAAGTTG +AAAAATTCCCGGCAAATCGCCAATTTTTTGCCTGTTGTGCATATTATTTT +CACGACTAAAAATCGTAATAAATTAAATTAAATTAAATTTGCCGATTTTT +CGACCGAAATTTGCCTACCGGCAATTCCTGCCGACTCCTTTTTGCCGAGA +AGAATTAAAATTTCCATTTCTAAAAAATCTGTAATTTGCCGGAGTTGAAA +ATTTCTGGCAAATTTGCAAATCGGTACTTTGCCGGAGTTGAAAAATTCTG +GAAACCGGCAACCCGGCAAACCGCCAATTTGCCGATTTTTCGACCGAAAT +TTTTTTTTCCTGTCGACCCCTTTTTCCGAGAACAGTTAAATTTCCAAAAT +TCTCTAAAAACCACAAACTTCTCAATAATAAAATTCGCACACTCCTGTCG +CTTCCCCTCATCATTCCACTCAATCCGCACAGTTTCTCGAGTACAGTACT +CCAAAAACTTGTCCAAATAAACTTGGAGCATTTGAGCCCGTTCTTTCGAA +GTCTGCGACGCCGACGCTGTCGACTTAATCGGCCCATTCCTCAGTCGTTC +ACACCAATCACCGGCTCCCGACGATTGACAGTACTCGTTGAGCACATCTT +CCGCATTTTCACCACTGGTAAGCGGGAAGAATGGTAGAAGACACTGAAAG +ACACGATCCAGGTCTGGTGTCGCTTTTCCGTACACTCCGAGACATTGATA +GAACACTAGGAACAAGCGAATCGCAATTTTTCGCACTGCCATCAAATTTT +TCGGGTAGACTGCTTTTTTGAGAAGCGATTCGATTGCATGACGTTGCCAG +CCTGAGAGAAATTGGGAAAATTTTTAATTTTTATTTAAAGGTGGGGTAGC +GCTAGTGGGGAAATTGCTTTAAAACATGCCTATGGTACCACAATGACCGA +ATATCATGATATAACAATTCAAAAAAATTTTCTAAATTTTATATGATTTT +TTGAAAATTGAAAAAATCTCAGTTTTTGTCTAATTCCAATTTGAATTACC +GCCAATTGAATTTGTTCTATGGAGCGCGCTTGCACGTTTTTAAATTTATC +TATTTTATTTTTTGTTATTTTTTGTTATTTTTCCACCAATTTTTAATGTT +TTCGGTGTATTTTTGCTCGAATTTTAGAGAAAAAGTCAAAATAAATGCAA +ATTTTCGATTAAAAAGCACGCTTACAGTCGTAAATCAGTGAAATTAATTA +ATTCAGGTTTGAAATCGTTTAAAATCGTTACTTTGTCATTTTTACGCCTG +TAAGCGTGCTTTTTAATTGAAAATTTGCATTTATCTTGACTTTTTCTCTA +AAATTCGAGCAAAAATACACCGAAAACATTAAAACTCGGTGGAAAAAACA +ACAAAAAATAAAATAAAATAAATTAAAAAACGTGCAAGCGCGCTCCATCG +AACAAATTCAGTTGGCGGTAATTCCAATAGAAATTAGGGGGGAAAACTGA +GATTTTTTCAATTTTCAAAAAATCATATAAAATCAGGAAAATTTTTTTGG +ATTTTTTATCATGATATTGGGTCATTGTGGTACCATAGGCGTGTTTTAAA +GCAATTTCCCCACTGGCGCTACTCCACCTTTAATTTCTGACGGTTTTTTT +TCGGTTTTCCTTGAAAAATCCTCTAAAAATCGATAATTTGTAAAAATTGC +GTTGTTTTTCCGGGATTTTTTTCGGTTTTCCCACGGGGTTCTGGCCTTCC +TCACTGAATTTTTCGCGCTCCATTGACAATCGCCCGTGTACTCCACACGG +ACAAATCACATTTAGTTTTACAACTAAAATCGAGCCGAGACGCGGCAGCC +AACGCGCCGTAAATCTACCCCAGATATGGCCTGGCCTAGTTCGGCGAAAA +CTCTTCCATTTCAATGTATGAGGGAAGCCAGAAATCCGTGTTTTCCTCAA +AAAAATCCTCTAAAAATCGATAGTTTGTAAAAATTGCGTTGTTTCTTCGG +TTTTTTTTGCAATTTGAGGGTTTTTTGTCGATTTAACACGGATTTTTGGC +TTCCCTCATATATTGAAATGGAAGAGTTTCTGCCGAACTAGGCCAGGCCA +TAACTGGGGTAGATTTACGGCGCGTTGCGTGTCGCGTCGCGGCTCGATTT +TAGTTGTAAAACTAAATGGACTTTGTCCGTGTGGAGTACACGGGCGATTG +TCAATGGAGCGCGAAAAATGCAATGAGGAAGGCCAGAAGCCCGTGCGGAA +AGACGGGGAATCTCCGAAAAACGGGGAAAATCTACAAAAAAATGAGTTTA +AAAAAGACTTCCTCAAAAAAATTCAAAAATTGTGGTTTTTTTTTTAATTT +TTTGTATTTTGATAAATTTTTTGCGACATCAAAAAATGGAAGAACTTTTT +TTTTTCGATTTTTGAATTTTTTGTTGGTGAAAAAGAAGAAAATTTCGAAA +ATTCGTTAGGGAATGGATAAATTTTAATCAAAAATCGATTTTTTAAAATT +ATTTTTTGCAGTTTTGCATAAAAAATCCAGATTTTTTCGCATTTCGCGCG +TAATTTTCATTTTTGTCGTTTTTTTTTTCTGAATTTTCCGAAATTTCTGG +AAATTTTTTCTTTTCTTGTTCTGAAGCTTATGCCTAAGCCTAAGCCTAAG +CCTGAGCCTAAACTCCAAAAACGCACCACTTCCAACAAGCTCCGGAGCCA +AACAGAGCACCTGCTCCAGTGTCCAAAGCCCGGATTCAGCCTCAATTGCA +CTATCGATTTGACTGCTGACATCGTTGACGAGCAGAAGCTCGTCAACGAG +ATGAAACGTCTCGAAACTGTGCTCATCGAGCAGTTGACGCTTTTCCTGAA +GAAATGTTGTGGTCGAATTAATGCGAAATATGGGAAAATTCGGGTTAAAA +TCGATGAAAAATCGTGGAAAAACGAACATTTGTGGTTAATGTGTCGAGCA +GAATCTTCAAATGTTTCACACGGCTCACACAATCCCTGTTCAAGTCGGTG +AATCTTGAAATGCTCGCCTGCACATCTGACGATTTGCCCTTTCGGGCAAA +CATTTTCCTGTGATTTTAGGCGATTTTCTGCAAATTTTCGCTGTTCAAAC +GTTTAAAATCGACGGAAAATGCGTATATTTTACTAAATATGCGAGAAATA +GTGATTTAATTCGAAAAAATCAATATAAAAATGGAAAAAAACTACAGTAG +TAATTTAAAGGCGCATACCTCGAAAGTTAAAATCGTGCCAGGACCCGCCG +CAATTTAGAATCGATTTTTAGATGAAAACTTTTTTTTTCTTACTAAAAAT +TAAAATTTTTCACTGAAAATTTCGGTTAAACTCTGACTTTTAACACGAAT +CTTATCAAAACTATGACAATTTCTAGTGAAAATCGCCAATTTTGTGTGTA +AAATCAATTTTTTCAGTGAAAAATGTTTTTTTTTGAGTTAAAACTAAATT +TCGAGCTTGAAACTAGAAAATGTCAAGTAAAAAATTCATTTTTAAGCGAA +AAATTAACGTTTTTTTCCAAATTTTCGCCTATAATTCACACAAAAAATAC +TGAGTCAGCAAACAATGTGGGAGCATCCCGAAAATGGTGCAGAATGGTAG +AGCAAAAACGAAAAATCGATGAATTATTGTGGAGAGAGAGGAAATTTTAT +TCAATTTTTGAGGAATGGAGGTTAAAAAAAAGAGTAGAAACATTGAAAAG +TGGCAAAGAAATCCAGCTTGAAACCGGAAAAACTCCCAGAAAACGAAGCA +AATAAGAAAATCCCACAAAAAATCCGAATTTAATTGCAGTTTTCGACCGA +AATTCAGCCAACCAGTGAGTGGTTCAATTATTAAAAAGCACATATATACA +TATAACTTTATTCAAAGGACATAATCCATATAAAGTCTGTCAAAACGGAA +AAGGTTCTTTCCAAACACACAATTGGCCCCCTCTGTCCAAAAGAGAGAGC +ATGGGAATCGGAGAGGGCGGTGAGAGAGACGCAGACATCGAGATGACACT +TTTTGACAGCAACACTGTGTGTGTGTGTGTGTGTGTGTGAGTCTCTGTGA +TTGAGTGAAAGCACTTTTGGGAATATATACTGGTAGAAATTTAATTTAAA +ATGATAAAAAATTTCTTGGGATTTTTTTTTTTGAGTACTGTAGCCACAAA +AGTACGTAATTTTCTTGAAAATGCGCCCATGGGGTCCCAATGACGTAATA +TCATGATAAAAAATTTTTGAAAATTGGAAAAATCTCAGTTTCCCCTCCCC +CCCCCCCCTAATTCCAATTTGAATTTCCGCCAATTGAATTCGTTCGGCGG +AGCGCGCTTGCATTATTTTTATTAATTTATTTAATTTTCTCTGTTGTTAT +TTCACTGATTTTCTTCATTTTTTGGGGATTTTTAATTGGGAAAAGAGAGA +AAAATGCAAGATAAATGCAAATTGTTCATTAAAAAATCACTGAAAATGGG +TAAAACTGTGAAATATGCTAATTTCAGGCTTGGTGTCGTCGGAACTCATA +ATTTCGCAGTTTTACCCATTGTCTATGATTTTTTAATGAACATTCTGCAT +TTATCTTTTTTTTTTAAATTCAATTTCTATTAAAAATCCCCAAAAAATGA +AGAAAATCAGTGAAATAATTAGAAAAAATAAAATAAATTTATAAAAATAA +TGCAAGTGCGCTCCACCGAACGAATCCAATTGGCGGGAGTTCAAATAGGA +ATTAGAGGGAAAACTGAGATTTTTTTCAATTTTCAAAACAAAAAATCATA +AAAAATAAGCATTTTAGCTTAAAAACTCGAAAAATCATACAAAAATTAAT +TTCAAGTTGTCCACGAGTAGTACGCGACGCCTGGTTGCAAAAATGGCGTA +GATTTCGATTATTAAAAGCTTAAAAATCATTTTTTTTTACCAATTTCCAA +TTAAATATCCTAATTTTAATCTCAATTTTCTTGAAAGACGTGCAAATATA +GATACATCTAACATAAAAATTCTTCGCTGCGAGACCCAGGACCCCATAAA +TCGCCTGCGCCTTTAAATTTATATTTATTTTCTCTCTCAAACAGCGATGA +AAATCACGTTTTTGAACCAAATTTTCCAAAAAATAAGACAAATTTCTATT +TTAAAAACCACTTTATTCGGTCATTGGTCGCTAAATAGCAAATTTTGAGG +CAAAAAAAAAACGAACAGACAACGGAAAATCGAGTGAAAACAAGTGAGAA +CACAGCAAAACTAGTCCTAATTAATTAAAGGCGCATCACGTGGAAAAGAA +AACTGTTGTGGAAGAATAAAAAATGGAACATGAGGGGAAATATTACAAAA +ATAGTAAAAGATGCATCAAGATTAAGATTATTTTTCGAAAATCGAGTCCT +CCGCCCAGGAATTCATCATAATTTTCGACTTTTTTTCGGAGATTGCTGCA +CATTGTCGGCTGCTCCGGTGGTTTTTGGAAGGTTTTGAGAGCTGAAAGAT +TTGAATTTTTTGGAATTTCGAGAAATTTCTTTTTTTTTACCCGAAGCGCT +TTGAATCTGGCGAGCTGCATTTCCAGCTTGCATTGTGCGTTCAGTGACTT +TGATTCCTTGAAGTTTTCTGAAAAAAAAACACGAGTTTTGACTTGAATTT +TCTGAATTTTTAACACGGATTTCTGGTTTCCCTCAAAGAATTGAAATGGA +AGAGTTTTTGCCGAACTAGGCCAGGCCATATCTGGGGTAGATTTACGGCG +CGTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAAATGTGAT +TTGTCCGTGTGGAGTACACGACTTTCCCACGCGTTGTCCGGCAGGCGATT +GTCAATGGAGCGCGAAAAATTCAATGAGGAAGGCCAGAACTCCGTGATTT +TTCTTTTACTCGGCGTAGATTTCGCAGTTTCAGACTGTTTTTCAGGTCTA +ATCAGCGGAATTTTCGTTGATCCCGCCAATCTCGGTGATTTTCTGAGCCT +TTTTCGCTCAGGTTCTGGGATTTCAGCTTTTAGAGCAATCTTTGAAATTT +CGACAAGTTTCTTGAAGTCCAACGCAATTTTTTCAGTAGAATTCGCAGTT +TCCGGCAATTTTTCTGAGCAAATCTTCGAAATTTCGACAAGTTTTCTGAT +TTTCGGCGTAGATTTCGCAAATTCTGACGGTTTTTCTGCAAATCCCGGTG +ATTTTCGGCTCGGGGAGCTCCCAGCTGCTCTATTGTTCAGCATTGTCTGC +TCAGTAGCGGGGGCGTCTTGATTTTCAGTAGAATTCGCAGTTTTCGGCAA +TTTTTCTGAGCAAATCTTCGAAATTTTGACAAGTTTTCTGATTTTCGGCG +TAGATTTCGCAATTTCTGACGGTTTTTCTGCAAATCTCGGTGATTTTGGG +CTCGGGGAGCTTCCAGCTGCTCTATTGTTCAGAATTGTCTGCTCAGTAGC +GGGGGCGTCTTGATTTTCAGTAGAATTCGCAGTTTCCGGCAATTTTTCTG +AGCTAATCTTTGGAATTTCGACAGGTTTTCTGACTTTTGGCGTAGATTTT +GCAGTTTCTGGTGATTTTCGGCACGATGAGCTCCCAGCTTCTTCATTATT +CAGCCTTTTCAGCTGGGCTTCTTGAGAGCCTGTAATCACGTCGCCGTCGT +CATCCTCTGAATCATCATCCGACCAAATTTCGATTATTTCCTGAAAAAAT +CGATTTTTTTTGCTTTTTTTTGCTCTTTTCTCATTGTCAGCTTTTCCCAC +TTTCCAGCAATTTCTCCACGGCGTCGGAACGTATCCTGGTCGCCGATCGA +ACTGGATAACTGGCCGGCTGGCGATAAATCGGCGAAGATCTGCTACTATC +TCGTCTGAAAACGTTTTTCTGCTAAAACCTGCTAAAAATCTGGCTAAAAT +CACCTGATAACATTACAATATCATCATTTCCGGGCATTTTTGACGAAAAA +AAAGCGGAAAATATTTAGAATTTCGAAAATGAAGAGAAGCGTTACGGTAC +TAAAGGCACATGGCGTAAAATATTCCGCAGGACTCGCCGCGATTTATGAT +TTTCACTATTTTTTTTGGGCAAAAGTTGACATTTTTCAGAATAAAATTCA +AAATTGTGTTGATAAATTGTTTATTTGATTTTTTTTTCAAATTTAAATAA +ACTGTAAATTTTAAATTTTCCCCCAAATATTCGCAAATTCCCTTCAAACC +AAGTTTTAATAGCACAGTAATCCCCGAGCAATCGCGCTCCACCGGACTAA +CCTACACACCGCGAATTTTGAATTACATCCCTCATAATTAATTGTTTTTG +CCATTTTTTCGCTATTTCCAGTGGATTTTAATGAGTAAAAGCCTACAAAC +CGACGAAAATGGCGGTGTCAGTGAAAGTCCATCAAATTGCACATATTGCT +ACACGCTGGAATGCTCTCTACGCATCGAATCCACCTCATCAATCAAGAAA +AAGACTCCAATCTCCTCGAAAAGCGCTATAATGACTGTCGGCAGAAATGC +GCAGAGGTTTTAGTCGAATAAATGCCTGTTTTAAGAGCAAGAAATTCCAG +AAAAATTCACCTTCAAATCGAGCTAAAGACCACCGCTACCGGACAGCCCG +CTGTAGTGTGCTATGACGTCACAGATGCAGTTGTACACTTGCAAAGCGTT +GCAAATGGGAAGTGTACTGTAGAAATTCCTTCGCTGTAAGACCTAAAAGA +CCAGAAAAATGGAAAATATCTGAAAACCCCAATTTCAGCTCGTTAATGTT +CCAAATGTTCAATTGCGCGCCGCGAAAGCTCAACGTCTTCATGAAATCTC +TCCAAGCAAAGTTGGATATTATGAAAATGGAGAAAAGCCCAATTTCAGCA +GTGTAAAATCGATAAATTATCGAAAAATCAATAAAAATCCCTTCAGACCC +CGGCAATTCTCACGTCCGCCGGCAGTTTTCAGCGTTCTGAGCCCGCTGAC +GATCAGCGAAATGCGAAAAGTGAAGAAGCTACGCGAACCGTCGGCGCTGG +CGAGACCTTCGAAAGAGGCGACCACACCGAAGCGGCGGTAATTTGAAATT +TTCACATTAAAAAAAAATCGCGAATTTCAGCACTTCCTCAATGAATTTGC +TCGCCGGCGGCTTGGAAAATCGAATTATGAATCGATCGATTGGGCTGAAA +AGGACGACCAGTTTTGCTAGAGATGATCGTGAAAAAGCCGAGGTTCTGCA +GCTAAAAATCCGTCAAAAATCGATAAAATTTCGTTTTTTTTCCGTGAAAT +TCCAGGTTTTTTAGTCCAAAAGCACGGATTTCTGGCTTCCCTCATAAATT +GTAATGGAAGAGTTTTTGCCGAACTAGGCCAGGCCATATCTGGGGTAGAT +TTACCGCGCGTTGCGGCTCGATTTTAGTTGTAAAACTAAATGTATTTGTC +CGTGTGAAGTACACCACTTTCCCATTGCCCGGCGGGTGATTGTCAATGGA +GCGCGAAAAATGCAATTAGGAAGCCCAGAAACCCGTGAAAAAGTGTCACG +CGGTTTTCAAAGTAGAGGTGCAAGCGCGCTCCACCGCTCCACGGTGCTTG +GCGGCAAAACCAGAATTTTCGCTGATTTCAAGCATTTTCCGTCGTTTTTC +ATGATTTTTCATGTCGAAATAGTGTTTAAAAATGTCTTTAATGCTGAAAA +GTGAATATTTCAAAAATTTTGACATGAAAAACTGAAAAAATTATCGGAAA +AGTGTATTTTTTGAGTTTTTACTTATTTTTCGGTTTTTAAAAAAATTATT +TCTACATAAAAATTGATGAAAACAGCATATGAAGTGCAAAAAATAAAGAA +GACTTACATAAATTTTGACAAAAAATCACGAAAAACAATAAAAAAAGTCG +AAAAATGATTGGAAACGGAGAAATTTTCCCTTTTTATGTAGAAATTTTGA +ATTTTTTCAAAATTTTCTCAATTTTGAAACACAAAACATGAAAAATGATT +GAAAATATTTGAATTTTTAGTTTTCGCGCCAATACCTAACGAGACCCATC +GGTGTGACCATGGAGCGCGCTTGCATCTCGATTTTAAAATTCGTATGAAT +TTTTCGCGCTCCATTGACAATCGCCTGCCGGACAACGCGTGGGAAAGTGT +CGTGTACTCCACCCGGACAAATCACATTTAGTTTTACAACTAAAATCGAG +CCGCGACGCGACACGCAACGCGCCGTAAGTCTACTGAGCCAAAATGGCCT +AGTTCGGCAAAAACTCTTCCATTTCAATTCATGAGGGAAGCCAGAAATCC +GTGTTTTAACCTAGAAAATCAAGAATTTTTTTGGGAAAAAATGCCAAAAA +TCCCAGATTTTCCCTAATTTTCAGCTAATTTTTCCCCGAAACAGACAATT +TTCAGACCCTTGTCTCCCTGAAATCATTCAAAGATGCTCCTGCAATTTCC +GAACGGATTCAGCTGTCAGATGAGCAAAAATCGGTTGTCCGATGTGTGAT +AAATGTAATTTTTCGTTCGAAAAAAAAAATTATCGAAAATTTGCAGTCTC +GAACGAGTGTCTTCTTCACGGGATCCGCTGGAACCGGAAAATCTGTGATT +CTTCGGAGAATCATTGAAATGTTGCCCGCCGGGAACACCTATATCACCGC +AGCGACAGGTAGAGGATCACTTTGAAATATTTGCAAAAAATCGTGTCAAG +ACCTCCCCCAAAAAATTTTCATGTACCTTTAAAAAATAGAACCGACTTTT +TTTAATTAAAAAATCATTAAAAATTAGAGGAAAATTTGGGAAAAAAAATC +ATTAAAAATTCTTTAAATAATAATTGTTTATTTGTCACAAGAAATAGCTA +CACCGGAAGATAAAGAAAAAAAGTAAATAAAAAAGATGTGTGGACAAATA +AGTAAAATGACCAATTGGACCAGCTATAGCCCGGGAGGTTAAGTTGGGGG +GAAGAGGGTGTCAAATGGGATAGAGTCTAGGCGCGACGCAAATGCATTTG +GAGTTAACAGTTTAGGGAAACGTTTTGCTATTCGATTCCACAACGACAAG +TTAACATGTAGAAAACATTTAGACGGAACACCACAGACAACAAGTAGATA +GGGGTGACGAGTAGAGCGTGAAGCTCGAACGAACGATGATAAGGACGGGA +AGTGATACTCGCTTGAAATAATTTTATGGAAGGTTCGGAGGATTTGAAGA +ACCCGTCTATGGTGGGTAGACAATAAATTAAATTGGGAAAGCCTACTACT +GTATGACGAGTAAGATAAATTGCACCTTTGAAAGACACACTTTGAGAAAA +ACCGGAGGGGAGATTCTAGTTTTTTGGCAAGTTCGGTGGAGTTGGGCGGG +AAGAGCTCGCAGCCATATTCGAGTACGGGGCGGATGTAAACATTGAACAG +TTTAAAATAGAATTCGGGACTTTTAGAGCGGAATGAACGAAGGATTTGGC +GACACTTAAGGAGGGCACTATTAGAAGTCTGATTAATATGATTAACAAAT +GATAATTTGGTATCGACAATGATTCCAAGATCTCTGATAGAATCACGCGG +TTTAATTTCAACACTATTTACAAAGTATTTATGACGGGGGTTCTTTTTTC +CAAAATGTAATACGGCAGTTTTGTGCTCAGCAAGATTTAGACGCCATTTT +TTACACCAATCAGCGACAATATTGATGCTTGTTTGGATAGAGGTGGGGTC +CGATCCGAGTAATTTTAGATCGTCGGCAAAGGCTGTAACATGGACATCAG +GGGGGAACAAATCTAATAAGCCATTAATATACAAAAGAAAGAGGAATGGT +AAAATTGTGGAAAAAACCGTAAAAAATCAACAAATTTCGAAAAAAAATCG +TAAAAAATTGAGACATTTGAAAAAAAAAATCTAGCAAAATTTGAAAAAAA +AATCGTTTAAAATTCAGCAAATTTATTTTAAAAAATCATTAAAAATTCAG +CAAATTTGGAAAAAAAAACAAATAAATCTGTAAAATTAAAAAAAAAACCA +GTAGAATTTGAAAAAAAATTGTTTAAAAAATTCAGCAAATTTCTAAAAAA +AAATCATAATTAATTGATAAAAATTTTTTAAAAACGTAAAAAAATATTTA +AAATTCTGCAAAATTTGAAAAAAATCGTTTAAAATTCAGCCAAATTTCGA +AAAAAAAAGCATTAAAAAAGAGAAAAATTGGAAAAATTCTGCACAATTTT +TTAAAAATTATTATTCTGAAAAAATTTAAAAATTCATGGAAAAATCTGCA +AAATTATTTTTTAAAAATCGTTAAAAATTCAGCAAAAATTGGAAAAAAAT +CGTTTAAAAATCAGCAAATTTCGAAAAAATAAAACATTAAAAATTCAACA +AAATTAAAATTAGAAAATCATTAAAAAATACAGCCAAACCGTAAAAAATC +AGCAAATTTCGAAAAAAATTCGTTAAAACTTCAGCAAACTTCTAAAAAAA +ATCATTTAAAAATGCAGGAAATACGAAAAAGAAACATCAAAAATTGAGAC +AATTGGAAAAAAAATTCGTTAAAAATTAACCCAAATAAATTTGCTGAATT +TTTTAGATTTTTTTTTTTATAAATTTGCTGAATTTTTGAAAAAAATTCAG +CAAATTTATTTTAAAAAAATCTAAAAAATTCAGCAAATTTCTTTTTTAAA +AATCGTTAAAAATTCGGGAAAACTTGGAAAAATTGTGCAAAATTCAGAAC +AAAAAAATTTCAAAATTTTCCCAATTTTTAAGTTTTTATTTAGTTTTCAG +AATTGTTTAATAGTGAAAAAATCATAAAAAATTCAACAAAATTTAAAATT +CAAAATTTTCCAGAATTTTCATGGGTCCCGCCACGATCCACTCCAACCTT +CAAAAAATCATGTAATTTCCAGGCGTTGCGGCTTCCCAAATCGGCGGAAT +CACACTTCACGCGTTTTGCGGTTTTCGCTACGAAAATTCGACGCCTGAAC +AGTGCCTAAAACAGGTTTTACGCCAAAATCACATGGTCCGACAGTGGAAA +CAATGCTCACACTTGATAATTGACGAGATTTCCATGATTGATCGCGACTT +TTTTGAAGCTCTCGAATATGTGAGCTCATTGCGTTTTGATCTACAAAAAA +TGCGGGAGTTTTCCCAGCATTGCTCATTTGATCTACAAAAAATGCGGGAA +TTTTCCCAGCATTGCTCATTTGATCTACAAAAAATGCGGGAATTTTCCCA +GCATTGCTCATTTGATCTACAAAAAATGCGGGAATTCTCCCAGCATTGCT +CATTTGATCTACAAAAAATGCGGGAATTTTTCAAGTGTGACGTCAGCACA +CTCATGCGAAATCTGCTGAAAAGTCTGCGTCTCTTCTCCCGCATTTTTCG +GAGATCAAACCAAAATGGGACCCGAAAATTCCAAAAAAAAATCGATAATT +TCCCGTCCCAGGTCGCCCGTACCGTCCGTAATAACGATAAGCCGTTCGGT +GGAATTCAGCTCATTATCACTGGAGATTTCTTTCAATTACCGCCCGTCTC +GAAGGATGAACCAGTTTTTTGTTTTGAGGTGTGCGGAATTTCGGAGCATC +GTTTGGACCGTCTAACTCTTAAAAAAATTTTTTTGCAGAGCGAAGCCTGG +AGCCGATGTATCCAAAAAACGATTGTCCTGAAAAATGTGAAACGACAAAA +TGACAATGTTTTTGTGAAAATTTTGAATAACGTTAGAGTTGGAAAGTACG +TAAACTACTGGAAAAATTTAAAAATTTCGAATTTTTCAGGGTTTTTTACT +AGAAATTTTGATTTTTTTCAGTGAAATTCCAATAAAAGCTGGAAATTTTC +AGAAAAAAGGAAAAAATATGAAAATTTGTAATTAATTTCGAAAAATGCTG +AAAATCTCCAAAACCTTCCAGAAAAGCTGGAAATTTCATAAAAATTTGGG +AAAATCTGAAATTTTCAGAAAATTCAAAAAAAGCAAAAAATCTCGAAAAC +CTTCCAGAGAAGCTGGAAAATTTCAGAAATTTCCAAAAAAATAAATTCTG +AAAATTTCATAAAAATCACTGATTTCTGTCTTCCCTCATAAGTTGAAATG +GAAGAGTTTTTGCCGAACTAGGCCATTTTGGTTCGGCCAGATCTTGGGTA +GATTTACGGCGCGTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAA +TTAAATGTATTAGTCCGTGTGGAGTACACGACACTTTCCCACGTGTTGTC +CGGCAGGTGATTGTCAATGGAGCGCGAAAAATTCAACGAGGAAGGCCAGA +ACCCCGTGATAGACCGGCCAACACGGGGTTCTGGCCTTCCTCATTTCATT +TTTCGCGCTCCATTGACAATCACCTGCCGGACAACACGTGGGAAAGTGTC +GTGTACTCCACACGGACAAATACATTTAGTTTTACAACTACTAATTGAGC +CGCGACGCGACACGCAACGCGCCGTAAATCTACCCCAGAAATGGCCGAGC +CAAAATGGCCTAGTTCGGCAAAAACTCTTCCATTTCAATTTATGAGGGAA +GCCAGAAATCCGTGTGAAATTTCCAAAAAGAAGCTCCAAAAAAAAATTCC +AAAAAAATCTCGATAGCCTTCCAGAAACGCTGGAAATTTCAGAAAATCTC +CTGAAATTGATAAAAATTCGAAAAAAATCTCAAAATTGTTAGAAAATCAG +TGAAAATTTGGAAAATTCAGAAATTAAAAAAAAAATTTTTTTTTGGAATT +TAGAATTTAGAATTCTTCAAATTGTCGAAAAATGCTCCAGAAAACTTGTA +AAAATTTAATTTTTTTTTTTTTGAAATTTCCAAAAAATTTATTTATTTTT +CAGATGCGACTTCAAATCAGCGGATATTCTAAAGGAATCCTCGAAAAATC +AATTCCCATCCAGCGTAATTCCAACCAAACTGTGCACACATTCAGATGAC +GCCGATCGAATTAACAGCTCAAGCATCGAGACAACACAAGGCGACGCGAA +AACCTTCCACGCCTACGATGACGAGAGTTTTGACACGCACGCCAAGGCCC +GAACGTTGGCACAGAAGAAGCTTGTGCTGAAAGTTGGAGCTCAGGTGATG +CTCATCAAGAATATCGATGTGATCAAGGGACTTTGTAATGGGTCACGTGG +ATTTGTGGAGAAATTCTCTGAAAACGGGAATCCTATGATTCGATTTGTAT +CGCAAGCCGATGCTTCCATTGAGGCACGTTTTACAGAAATGACCATTTTA +TGGGCGTGGCTTTTTTTTTGGAAAATTTTTTTTTTCCAAAATTTCTGGAT +TTTTCTCTAAAATGGAAAAAACCCACGAAAATTGTAAAAAATTTGAAATT +TTTTAAATCGGAAAAAAATAAAATTTTCTTTCTTAAAATTAGGCTTAGGC +TTAAGCTTAGGCCTGGGCTTAGTCTTAGGTTTATGCTTAAATTTGAAAAA +AAAAATTTCTAATTTTTTCCAGATTTTTCCGTTTTTTTTTTCAGAGAAAA +TCTAAAATTTTCGATTTCTACCTGTTTTTCAAAAAAAGTTAAAAAAAACA +TTTTCGCAAATTTTGTAGAAATTTTTCTTTTTTTTTTCTTAAAATTAGGC +TTAGGCTTAGGCTTATGCTTAGGCTTAGGCTTAGGCTTATTCGTAGGACT +ATGCTTTGGCTTAGACTTAGACTTAAGCCTAAGCCTAAGCCTAACCCTCT +TAAAAAGTTACAAGAAGGTTTTTCCTTGCGCTTGGAGCGCAAAAGAAAAG +AAAAAGAGCTATTCAGACTTAGGGTGCCCAACTGGAATAAAACATTGGAA +ATCCTTATGACACACTTAAGCCTAAAGGCCCGAAAAACATACTAGGATGC +CCAACTGGAATAAAATATTGGAAATCCTTATGACACACCGGCGGTATGGC +GCGGCTTAAGCCTAAATAGCCACTTTTATCAAAATACATTTGAGCTCGTC +TTGCGTTTTACTTTGACTTCTCAGGCAACTCAAAAGTAATCTGTGGATAT +TTTTCAGTAATCTAAATGAAGACTATAGATTACTAAGAAACTTGGAGATT +TCATAATATTTGGGGGGATGCGAGCATCCATTGGAGATTTGCCATTTGAT +AGAACTTTTAGCGGCAAAAGTCCAAAACAAAGCTCACAGTGGGCTCTCAA +AGATCATAAAATAGCACTGTAACGAAGAACTTTAACGATCTAACGAAGCA +ATTTTACAAATTCACTTTGGTAGCTCATATCTCCGTGGATAAAATTTTTA +CAGAAAAGTCATCAACTGATAAGTTGTTGATATTGTTGTAAAGAACAAGT +TTGTAGTTGAAAGTTTTTTTTACCAAAAAATTTTTGTTTGAGAGAAAAGC +ATTAGAAACGGAATAGCATCATAAAAATAACAACAGCAGTTGCCGCACTT +CACGCGGTTCTATCTCAAACAAAAGCGGAGATATGAGCTACCAAAGTGAA +ATTGGAAAATTGGCCCTCCAATGCTTCGTTAAAGTGCTATTTTCAGGATC +TTTGAGAGCCCGCCGTGAGCTTGGTTCTGGAGTTATATTGATCAAATTGA +CCCTCCAGTAAAGGAGGACCTTTGATGAATATAATCACTCTGATGGTATT +TAATTCCGATGAGTAATCCATTTTTCTTTTTCTCACATTTGTGAACCAAA +AATAAGTTTTAAATTAAGGCGGGATATTCTAAGGTGTGATAACATATGTT +ATTTATTTTTAAATTTAAATAAAGTTTTTTTTTAATTTTTGCTAAAAAAC +GAATAGTTTACAACCGCCTCGCTCAAATGTATTTTGATAAAAGTGGCTAT +TTAGGCTTAAGCCGCGCCATACCGCCGGTGTGTCATAAGGATTTCCAATA +TTTTATTCCAGTTGGGCATCCTAGTATGTTTTTCGGGCCTTTAGGCTTAA +GTGTGTCATAAGGATTTCCAATATTTTATTCCAGTTGGGCATCCTAGTTT +TTTTTTTTCGGGCCCTTAGGCTTAAGTGTGTCATAAGGATTTCCAATGTT +TTATTCCAGTTGGGCACCCTAAGTCTAAATAGCTCTTTTTCTTTTCTTTT +GCGCTCCAAGCGCAAGGAAAAACCTTCATGTAACTTTTTAAGAGGGTTTC +ATATATTTTATTAAAATCGGGGCGAAGCCCTGATTTTAAATCCATATTGT +TTTTGTTTTTGTCTTCCACTATCCCTGCAAATAGGAAAGAGAATGTGTTC +TTTCTGATGAAGTAAAAATCATCATAAAATCTTGAAAACTGAGAGCAGGA +GGTAATATTTGAATATATTGGGTTGTAAATGTGTGTCTCCCTGTGGGTGG +GGTGGCGATGTGTTGGCAGCCAATCCTTCAACGAACTGTATCTCCCGCCT +GTATCTCCCTTCAAAGTGAGAATTGGGTTACAAAAATTTGAGGGAATATG +AAAAAAGGTGTGAGGATTTCAAAAATATTATTGTTGAAACACCAGACCAA +ACCACTTTTTCTGGGCAAGAGACAGAAAATTAATTTTTTGAAAAATTTCA +AACTGGCACAAAATTTTTTCAAAAACAAATTTTCACAAATTGTTAAAAGA +TGCCATTTTTAATCAATATTGTTCATTGAACACAGAAAAGAAAACGAAGA +TTCATCAAAAAATGAGTGAAAAATCGCAAAAATTCGAAAAAATCCGTGCT +GAAAAACTCGAGTTTTTGGCGGTGCTGAAAAAAATTTTCACTAAAATTTT +TTTGAAACTTAGTTTTTCGGATTTAGCGTCAAATTTTGAATCTATATAAA +AAAAAAAATTAAAATTGATCTCAGATTGAGTGAATAATAAACGCTCAAAG +TTGAAAAATGAACAACGCAAAAACGGCAGTAACTTGCTTCAAGGTCGGTT +GTCTCAGTGAGTTTTCACTCAATTTTCGAAATTTTTTTGCTCTATCGCTT +TAGAAATATTTGTAATTTCATTTTTTTTCCTCAAAATCAAAATATCTCAA +ACGACCGCCATCCTACGAGAAGGGAAAAAAAAAGTTTTTGGAAAAAAAAT +CAAAAATTTTTTTTCTGCCTCGATTTTCAAAATGAAAAAATCACTTTTTC +GGAATAAACTTTTTCACAAATGTATTTTGATAAAAGTGGCTATTTAGGCT +TAAGCCGCGCCATACCGCCGGTGTGTCATAAGGATTTCCAATATTTTATT +CCAGTTGGGCATCCTAGTATGTTTTTCGGGCCTTTAGGCTTAAGTGTGTC +ATAAGGATTTCCAATATTTTATTCCAGTTGGGCATCCTAGTTTTTTTTTC +GGGCCCTTAGGCTTAAGTGTGTCATAAGGATTTCCAATGTTTTATTCCAG +TTGGGCACCCTAAGTCTGAATAGCTCTTTTTCTTTTCTTTTGCGCTCCAA +GCGCAAGGAAAAACCTTCTTGTAACTTTTTAAGAGGGTTAGGCTTATGCT +TAAGCTTAGGGTTAGGGTTAGGGTTAGGCGTAGGCGTAGGCTTAGGTTTA +GGCTTCGGCTTCAGGAATATTTAAAAAAAAAATCGAAAAATAGATTTTGC +GAAAAAAAATCGTGATAAAGCCTGCTAAAATTTTCAAAAAAATTAAATTT +TTCAAATTTTTCAAATTCCCAAGATTTTGGTCTCGCAGCGAAAACATCCA +ACTACAGTAACCCTCGCCCTCTCCAATTTTCAGATCCGCCGCTCCAAGTT +CTCAGTCCGCATTCCCGGGAGTGATGCTCCGTTGATTCGCCGTCAACTCC +CACTCCAACTCGCCTGGGCCATCTCCATTCACAAATCGCAGGGAATGACG +CTCGACTGTGCGGAAATTTCGTTGGAGCGCGTTTTCGCCGACGGACAGGC +GTATGTGGCGTTGTCGCGCGCACGATCACTGGCGGCAATTCGAATTATCG +GCTTCGACGCGTCGTGTGTCCGAGCGAATTCAAAGGTGAACAGGGGATTT +TCGAGATGGAAATCTATGAAAAATGGATGGATGGTGTTAGATATCTCCTT +TTCGTGGGTTCTCTCACGTGGTGTCAGAGTGCCTCATTTCGGCTTGATCT +ACTGTGTAGATCTACAAAAAATGCGGGAGATGAGGAGACTCAGACTTCTC +AACTGGTTTCGCATGGTTTAGAACGTGCTGACGTCACTTTTCTCTGGGCA +TAAAATTCCCGCATTTTTTGTAGATCAACCGGTAAGGGATCTCTCAGCTA +CGTGGAAAATTATCGATTTTTTATCGAATTTTTTGCAGGTTATCGATTTT +TACAAATCCATCGAGGCAGAATGCGACGACGAACAGGACTGGGAAGCCCC +TGCTGCTGGACCAAGGCTCAAGCGAGTTCGATCGATTTAATTTTTTTTTT +TAAATTTTTTTGTGATCTCCAAATGTTCTGTCTTTCTGTCTTCCCCCCCC +CCCCGCCAAAATTCATTAACTGTTTTATTTCACAACACTCTGTATCATCA +TAATTTTCACATAAAATTGGCTATTTCAATGTTGACGTCGAATTTTTAGT +CCTATCAGCGTCATCGGATCTGAAAAAATGGAAAACTTGAACAAAAAAGC +AGGGGGTGGCCTAGAAAGCACAAAAAAAACTCGGACACAGTTCAACGGAG +GCAGTTTTTGGAAAAAAAAAAACGTCATTTTCGTATAGCCACACTGAAAT +TGAAAGAATTCTGGCCGAGTTTTCCAAATTCTAGGCCACCATGCAAACCG +ACATTTTGGGCGGAAAAGTGCCGGTGGCCGTGGAAGAAGGAAAAACTCGG +CCACTCTTCTATGTACTCCTCTCGGAGAATTGTGTTTTCCATGGCCGAGT +TTTTGTGTTTTCTAGGTCATGTCGGCATTTTTCTTAGTCAGTTTCAAAGG +AAATACGATACCTGGTCTCGACGCGAAAATTTTTTAATTAAATCCAAAAA +GACGTGCGCCTTTAAAAAGTACTGTAATTCCAAACTTTCGTTGTTGGGAA +ATTTTTATCGATTTTTCGTAGTTTTCAAAAAAAATAATCAAATGTACACA +GGGTTCTGTTCTTCCTTATTGATTTTTTCGCGCTCCATTGACAATCGCCC +GCAGGATAACGCGTGGGAAAGTCGTGTACTCCACACGGACATCGAGACGC +GACGCGACACGCAACGCGCCGTGAATCTACCCCAAATATGGCCGAGCCAA +AATGGCCTAGTTCGGCAAACTCTTCCATTTCGATTTATGAGGGAAACCAG +AAATCCGTGAGTAGTGAGAAAAACAACGAAAAAATCGATAAAATTTCCCA +ACAACGAAAGTTTGAGATTACAGTAGTCTTTAAAGGCGCACACTTTTTCG +CATTTAACATAAATTTGTCGTGGAGAGAGTATTTTTGGCGCAAAACTTCG +CATTCGGGTAATGATAATAGAAGAATTGAAACTCACAAATTCTCCGCCGT +CTCCTCAAGCAGCAGCGGCACAATAAACATGAAATACACGGCCAACACGA +AATGAATCGGCACCATCGACACAATGAACAACGACATTCGGAGCATGTGC +TCCAAAACTGTCGGCCGCAACTTTTTCGACGGATTCTCAAAGACGAGATA +CACTTGCATCGGGCTGTGCACATCTTGAACCGACTTCTTCTTCATTACAG +CGCTCCCTTCTCTGGGCAGCAGGTAGCGTGTCCACGTGGTGTAGGGTGAC +TCAGTGGTTGTGTGATTTATCGGCGTGAGCTGGAGCATTTTTGCAGAGTC +GCAGGCCAAGGTAGCGGAGGTGTTGGCTCTGAAAGTAGATTTCATACAGG +ATGGTAATTTCGGGGAGTACTGTAGTGGTGTTATAGTGGTACTGTAGGAG +TACACTGTAGGGGAACTGTAGGGGTGCTGTAGCAGTACTGAGGGGGGTAC +TGTAGGAGTACTGTAAGGGTGCTGTGGGGGTACTGTAGGAGTAATGTGGG +GGTACTGTAGGAGTACTGTAGGAGCACTGTAGGGGAACTGTAAGGATACT +GTAGGAGTAATGTAGATGTACTGTAAGGGTACTGTAGGGGTGCGCTAGTG +ATACTGTAGGGATCATGTAGGAGTACTGTAGAAGTCCTGTAAGGGTACTG +TAAGGGTACTGTAGAGGTGCGCTAGTTGTACTGTAAGGGTACTGTAGGGG +TACTGTAGGTGTACTGTAGGAGTAAAGTAGATTAACTGTAAGGGTACTAT +AGGGGTACGCTAGTGGTACTGTAGGAGCACTGTAGGCGTACTGTAAGGGT +ACTGTAGATGTACTGAAGTAGTTCTGTAAAAGGTACTGTAGGGGTACTGT +AAGAGCACTCTAGGGGCATTGTAGGGGTACTGTAGGTGTACTGTAAGGCT +ACTGTAGATGTACTGTAAGGGTACTGTAGTTGTTCTGTAAAGGGTACTGT +TGGGGTACTGTAGGTTTACTGTAAGGGTACTGCAGGGGTGCTGTAGGGAT +ACTGTAGGAGTACTGTAGTGGTTCTATAGGAAGACAAACTTTTTTTTGAA +TTTACTCATCGGAGAATCTAATATTTTTCACCAAATCGATACACCATAAA +AATTTTAGGACCCAAAGCTAAAAAAAAAAACCAACTTCTCCAATATCATC +TCCATCAATTCCAGTTGTTCTGTGCAGTTCGCCATCCCTTCCTTCTTCAA +TTCCTTCGCCCGATTCTCCAAATCGTCCACCATCTTCACACCCCGCCGAC +ACGCCGTCTCCACATACCGTTCCGTACCAGCTTCCGCAATTTTCATAAGC +TTCTCGACAGACTCGTTAAACTTGCGTGTTGGCTTGAACAAATGGGAACC +TCGAATCGCCTCGGGAACCGGATTTCCACCTCCTTCCACCAGGAGGCTGA +ACAGTGTCGTTTTCTGCCTGACGGCCTTAGCCAGGACGTGCCCATAGTTG +ATCATGTAGATTTGCCCGTTTTCAGATATGTTGAATGTTTCAGCAGATGA +GAACATTTGAAAATTATTTGATTGTGCGTGTTCATGCACCACAGTAATGA +ATGCGAGGCGGCAAATTAAAACTCTGAAAGTTTAGATAATTGTACTTTAG +TTGAAATCTACTTTGGTTGACAGGTGCATCGACTAGACTAAAAAAAAAAG +CAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTA +GGTAGGTAGGTAAGTAGGTAAAGCGAGACACGGTGCATCGATCTGACTTT +AAAAATCTCAATCTCGTATCTTAAGCGTCTTTGGTTCTGTCAGGGAAGCA +GGTAGGGGGGAGGTAGGTGTGATCAGGCAGAGCACCGGAGTTAATATCTG +GTGGATTGTGGGCTGCTAATAGGTAGGTAGGCAGGTAAGCAAGCAAGCAA +GCAGGCAGGTAGGTAGGTAGGTAGGTAGGCAGGCAGGTATCAGTTGACAA +CTTTTTGATGAAACTAAACGGAGCCGAGTTATAAGGTGCCAAAGTTGCAC +TAGACATGGTGCATCGACCTAACTTGAACAACTCGTATCTCAAGTGTCTT +TGGTTCTATTTGGGAGGCAGGTAGGTAGGCAGGTAGGTAGGTATATCTTA +GGTTGTTTCAAAACTATTATACATTAAAAATCAATAAAAATATTTTGCAC +GAATTTTATCAGTTGACAACTTTTTGATAAAACTAAAAAGAGCCGAGATA +TTGTAAGTTGCAAAAGTTGAACGAGACATGGTGCATGGAAGGTAGGTAGG +TAGGTAGGTATTTAAGTAGGTAGGTAGGTAGGTAAGCATTCCGTATTTCT +CTCTACTTTGACAGCTTATATCCTGGTTGTTTTGTGTTGTATCAAAAAAT +GTTTAACAAAGATAACATAGAAAAATATTTAGCACGTAGCAAATTTAAAA +AACTAGGTTGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGAAAG +GCAGGCATGTAAGTAGTAGGTAGGTAAAAGTACTCACGTGGAGAACATCA +AGCAGAAGATCGCTGAGCAAATTGAAAGTGGTACTGGAAGTTGAGCAAGT +ATTTTGGAGTATTTTTCTGGAAAAAAATAAGTATTCAAAGTAACTAAAAT +AAAATACCAACTCCGAAACTCAAACTTCATAATAAACAAAATCGTCAGAA +TCCCACTGGAGAGGACTGCAAAAGTCACTGTCGTGTTGGCAGACGTCTGA +TAAAAATCGAGGGTGTGTCCGGATGGTAGGAGAAGCACATTATCGTGATA +CTTTGACACAAATTCCTCAATAGACGCCAACGCTTTTCCGAAAACTGGAA +TCGAAATGTTCAAAGCATTGAGAATTATTTTCTGGTACTCTTCCACCAGG +ATGTTGTACTCCGAGTTTAGATCCGCTGAAAAATTTAAATTTGTATTAAA +TTGGGCAATACTCGTACTTGCCTACCTGCCTACTGGTAGGTAAGCAGCCT +ACTTATTTTCAACTTACAAAACTCCATATACTTTGTAACGTTTTCCAATT +TCGCAAAAATCGATTTCTCGAAATATTTGCACTTCCCCTCGACAAATGAT +TTCTTGGCGGGAATCTTCAGGAACAGCTGAAAATTTTTTTTTCCGGTGGC +CGAGTTTTTTCACGGCCACGACGTACCTTATTAAACATGGTGAAGTTGGC +GTAGTCATGCAAGAACCAATTTATTCGGCGGCGTTCGTTTTCGGTGACGG +CGAAGTCTCGTTTGAACAAGCACGGTATGTAGGACAGCTTACGGTGGAGA +CGCTCTTTGATGGCTGGAAGTTATGACGTCATGAATAATAAGGGATGAGA +TTTCTAGGCCACGTGTGACGTCACAGCAATCCCCGAAACCTTTTTGGATG +GCCGAGTTTTACCGATTTCTAGGTCATCGAGCGAAACTTTTGTGATACTT +TGGCAATGGTCATCAGGTAGACAAACAACGTGATAATTTCTAGGCCACGC +TTGACGTCACGTGGCCGAGATTTCGCGCCAGGACCTAGAACTAGACATGG +TGCATCGACCTAACTTAAACAACTCGTATCTCAGGTGCCAGGTAGGTAGG +TAGGCAGTCAAGCAGATAGGTAGGTAGGCAGGTATTTTAATTTCATTTCT +GCGGCTACAACACAATTTCTCTTCCAATCAAGGACGTAAATTTCTAGGCC +ACACATGCAGAGTGCGGACTAATAATTAAAGTGTTTTACGACATGGCCGA +GAAAAGAGAAACCTAGGCCATGGTAGTTAGGTGTGACGTAACGCCACTAT +AAAACTATAAAACTCACGCATAAAACTGTGATCATTGGCGGTTTCGAGCA +TCGTCCTTCCATAGACCGCATCCTGAGTACACTCTCGTAAATTGGCGGCC +AAAATTGTTAGACCAAGGATACAAAATATGGGGATAATGGTGAATCCGGA +GCGATTATCATCCAACCAATACACGATTACTTCGATAACCTCGAAGAGCA +GCAATTTCCAGACGACGAGGAATATCAGCAGAGCTGTGATCAGGCAGAGC +ACCGAGATTATTATCTGGCGGATTGTGGGCTGAAAATAGGTAGGTAGGTA +GGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAGGTAAG +TAGGTGGTAGGTAGGGAGGCAGGTATCAGCTGCCAACTTTTCGATAAATA +TTAAACGGAGCCGAAATATAAGTTGCCAAAGTTGTACTAGACATGGTGCA +TCGACCTTACTTAAACAACTAGGTAGGTAGGTAGGTAGGCAGGCAGCTAG +GCAAGTAGGTAAACTCACCAAATGCCTGAAAACAATTGCAAGAACATCGG +AATAACCCGAGCTCCTCCCGTTCAACGTCGCGACCACAAGCGCGTGCACA +CTTTTCCGCAGCTTCTCATCATCGCGATCAGCGCAAAAATCCTCGATTAT +CTCGAATCGATGGCTCTTTTTTGTGTGCGCCGGGTCTAATTTATAGCTGA +TCGGCTCGGGAAACCAATCGTCACACTGCAGCTTCGCATCCTCCAAGCTG +AAGCCGTGAGAAAACTGTGCACTGCATAGGAATAGAAGTAATTTCAGTTT +CATTTTGTTCTGGAAGAAGGCATTTTTATGGATGGAGTTTGAAAATAATA +ATTAAAAAAAAAACTTACAGCTGGAACTTTGTGAAATCGATAATGAAACA +ATAAATCTAAAAAAAGCTCAAAAAATTTTTGACAAAATTTAAAACTGTAA +CGTGTATGAAGGTCACGTGAAAACTGAAAACTCACCAAAAATGTCGAAAA +ATAGCAAGAAACTAGGCACACGTAGACTTATGGTAGGCAGGAAGGCGTAG +GCGTTGATCCAGGCAGGGTCACGTCTTGAAGGCAGACTGTTAGGTATAGG +TAGGCATAGGTAGCCATGTAGGCGTAAAGGCAGGAAGGCATCTCTAGATC +CTTTTTGTGGCAGATTGGCCGCTTTGCAGGCAGGCAGGTGTGGGTGGCCT +AGTAGACCGAAAAACAAGCAGGTAAAGTTCCTATAGTAGTAGGTAGGCGA +GCCAAACCTTTTTTGTAGATGATGAAGTAGGTGTAGGCCGTCTTTTGAAG +GCAGTGAGGCAGACAAGGTTAGGTCGTCGCAAAGGTTGGCTGGAAGGTAG +GCACGTGGGTCAGCAGATAAGCGTAGGCAGGCATAGGCAGGAAGGCATAG +GCAGGTAGACGTAGGCAAGTAGACGTAGACAGGATAAGATTCAAATATGA +AAATCGTGAAAAGGGGAAAATTTCTTATTCTTCGAGTGCGCGACAGTATG +CGTAGGCAGGTAGGCGTTGGCAGGTAGGCGTAGATAGGTAGGCGTATGCA +GGTAGGCGTAGGCAGGTAGGCGTAGTCAGGTAGATAAGCAGGTAGTCGTA +GACCGGGTAGGCGTAGGCAGGTAGGCGCATGCAGATAGTCCTAGGCAGGT +AGGCGTAGGTACGTATGCGTTGGCAGGTAGGTGTTGGCAGGTAGGCGCAG +GCAGGTAGACGTAAGCAGGTAGGCGTAGGCAGGTAGGCGTAGGTAGCTAG +GCGAAGGCACGTAGGCGTAGGTAGGCAGGCATAGGCAGGTAGGAGTAGGC +GTAGACATGCGCACATGAAAACCTTATAAATGTTTCAACCCCATCATCAT +CATCCCATTTTTCTCTCGATCAAAACGAAAAAATGTGCGCAAACACAAAT +TGCATCCATTTCTCTCTCTTTTTTACTCACTTATATATCTCTCATCACTT +TATCCCCCGTTTTTCAATCCCTTCCAAACACTTCCAAAACTCTCCAGAAC +TCCTAGAGAGTAACACGAGAGAAAATATTTGAACTTTTGTCTCGACCAAG +TTTTTTTTTTTGGGATTTTTTCTTTGGATTTCTACAAATTTGATGTATTT +TTTCCATTTTTCGTGCAAAATATGGTAATGGACTAGGTTTTTGCTACGTG +GCCTAGAAAAATCTCGGCCACCGATTCTGAGCTGTTGCAGCGGCCGCGGC +CGAGGGTTTTTCTCTTCAATCGATACCAATCCCTCTTTTACGCAAGGAAT +CACGTGGAGTCAGAGTGTCTCATTTCGTCTTGATCTACGTAGATCTACAA +AAAATGCGGGAACTGATTTCGTATCGTTAAGAACATGCTGACGTCACATT +TTTTTATCATAAAATTCCCGCATTTTTTGTAGATCAAACCGTAATGGGAC +AGCCTGGCACCACGTGCTCTTCCAACCTTTATATTTTTTTTGACAAAATC +TTGAGAATTTCTAGAATTTCAACGAAAATCCAATTTTATACCTAAACTTA +AAAAAAAATTGCTAAATTGTGTTCGACTAGCAAAAAATGCACCCAGTTTT +ACAAAAAATCTTTTTTTCTGAAAAAAAATTCAGTGGAAAATGTCTATAAT +TTTCAGTAATTCATACTAAAAAAAATCCAATTTTTACAACAAGTTTTTGT +GGCCGCGGCCGAGGTTTTTCCTCTTCCACGTGGTGTCAGAGTGTCTCATT +TCGGCTTGATCTACTTAGATCTACAAAAAACGCGGAAACTGATTTCTCAT +GGTTAAGAACGCGCTGACGTCACATTTTTTTGATCGTAAAATTCCCGCAT +TTTTTGTAGATCAAACCGTGATGGGACAGCCTGGCATTACGTGAAAACAA +ACAATGCAAGCGCGCTCTAATGCGAATTTATTTGCTCTACCACCAGATAA +ATTCCACTTCTTCACAATAAACCTAAATATTTTTTGTGTCAAAATCTTGA +GAATTCTTAGAATTCCAGAATTTCAGCGAAAACCTAATTTCCGATTTTGT +TATTGTTCAGGGGAACAAGTGAGCCACACAGCTTCCGCTTCTGCTCCGAA +TTCGATTCCCCTGAGGCATTTTTGTTCGAAAAAAGCCTCATTTGTCATAC +TTGTCGGCAACTTTCTTCGAAGTTTTTGTTCTTGTTTCAAATAATTTTTC +TTCAATACTTGTTCCTTCCGTCCCAGCAGATGTTCTTTTGCGGGGGGGGG +GGGGGAGGGGAGAAAAAAAATAAGAGAAGAAGCAGAAACTCGACACTTTT +GTGTCCGCATTTCTCGTAAAGTTTTCAGATTTTTGAGCTTTTCAAGCTAT +AGCTGAACCACCTAGCAAATTTCGCCGCAGAGTTGATTTCTCCGGGAGTG +GGCTTTCTACTGGAGACCTCACTTTTTTTGCCTTTTACTAGAGCTTTTTA +ATTTTTTAATAATTTATTGCAGCTCTATGGATTTTCCAAAAAAAACCACC +GAAAAGCCCGAAAAATCAAAATTTTCGTTTTTAAAACCCTAAATTCCATA +CTCCGTCCAAAGAACACTCACATAAAAATGAAGAGATTTCGCAAAAAAAG +TGAAATCCAATTCAATTTATTTCAATTTTGAAGAGTGCGTTCGTCAGCTT +TTTTTTCGACAAAAAAAAAAGAAAATGTGTAGTGTAGTTTTCAACAGATT +TATTGTTTTATTAATATAATAGAAATCAAACCTTCTTTCTGCCTACCTAC +ATGGCTACCTACATGCCTACTTGCAAGTAGACCTGTCTATCTAGGTACTT +ATCTCACACCTCTTTACCTACATACCTACCTTCCTACTCACCTGCCTACT +CATGTAGACATAAGTGATCGTCAAAAAAGAAGCTGATGGATCAAAAGTTT +TTGGAAATTTATTTCGATTTTCAGGTTTTAAAAATTGCGGAAGATGTTTA +ATTTTTGACGATTAGTTTAGAATTTTTTTTAATTAAGAAAAAAAAATTAT +TATTTTATTTTTAAATTACTCCAAATTTTCTTCTGATTCCGAATATCTAT +GTGAAACTTTTTTTAATTCCTTGGTTTTATATCTAAGCTTAAAATCGCTA +ATTTCATTTGTGCACCCAAGAGATTTCGAATTTTCACGGGGTTCTGGCCT +TCCTCCTTGAATTTTTCGCGCTCCATATAATATTGACAACCGGGCAACGC +GTGGGAAAGTCGTGTACTCCACACGGACAAATACATTTAGTTTTACAACT +AAAATCGAGCCGCAACGCGACACGCAACGCGCCGTAAATCTACCCCAGAT +ATGGCCGAGCCAAAATGGCCTAGTTCGGCCAAAACTCTTCCATTTCAATT +TATGAGGGAAGCCAGAAATCCCGTGTAATTTTCGCGCCAGAGACGCCATG +TGTCGATTTACGAGATTGGTGTATATTTACAAAATGCGTAATATTTATAG +AATGCTGATTTCCGTTTTTTTTTTTTGAAAAATGTCATGTGTGCACAAAT +TAAATTCGGCGATTTTAAGCTTAAATATAAAATCAGGGAAATTTTTTAAA +TTTTTTTCACGTAGATATCCGGAATCAGGGGAAAATTTGGAGGCAATTAA +AAATGTCTCCCTGATCATTTAAATTCTTTAAAAGTACTCTTCAGAATCCT +TTTTTCCTAACCAAATAAAATAATTTCTGACGCCTTTTTTTTCTCTTTTC +AATAAGAAGCAAAAAACAGACGAACCTATTCCAATTTCCCACCACACCAA +TTCGTTCTTTCCGCATTCTTTTTCTTCCATTATTTATCTCCCTTTTCCTC +CATTCTCTGTGCTCTTATATATATCCATCATCCCATTTTCTTTCTTGTTG +TGTGGTATGCTCTTTTTCATCCATTATTCGAAAATTCTCATTTTCCAAAG +TTTTTTGTCAAATACATTTTAAAAATTTTTTAAACCAAATCTCGCCGTCC +ATCGATTTTAAAATACCTTTTTTGAGAAGTTTTCAAGAAATTTCATTATG +AAATTCGGTGTTTTCAGACAATTTTGAGTCTAATAAAACAATTTAAAATT +TTGACTACATCACCTTTAACTTGTAGAATGCCGTTTAAACACACTTATCA +CTTTTTCAGAATCCCATATGCAATGGTATCACTTGCTCCTGCTAATTCTC +ATGATCCTGGTCCTAATCCCATGTTTCTGGCAAGCTTGGCTACGATTTTC +CCGTCGATTCTCCGATTCCTATGATCTATCAAGAAATGCGCAAAAGCGTG +ATGAGATTTCAAAGGAGTTTTATGTATAGCTTACTGACAGGATTTCAAAA +AACAGTTACGGTAAGATTTTTCGAAAAATTTCACGGATTTCTGGCTTCTT +GCCGAACTAGGCCATTTTGGCTCGGCCATATCTGGGGTAGATTTACGGCG +CGTCGCGTGTCGCGTCGCGGCTCGATTTTATTTGTAAAACTAAAGGTATT +TGTCCGTGTGGAGTACACGACTTTCCCACGCGTTGTCCGGCAGGCGATTG +TCAATGGAGCGCGAAAAATTCAATGAGGAAGGCCAGAACCCCGTGCCTGT +ATAGGATATTTTGAATCTCAAAAGAATTTGAAGATTTGAGTTTTTTGAGT +TTGAGGTGGAAAAAATCGTAAAAAATTCCTTTCCGATAAATTTTCGGATG +CAAAAATGTGATCCATGCTGTAAAAAATCCAAGAAAGCCAAGAAATGTGC +GGAGCCTATTTTCCGATTTTATATTACTTTTTATTTCAAAACTTGATTCA +AAAATATCAAATTCGGAAAAAAAACCGCAACTTGGTAAAATTTCCTCGAA +AAATATTCTCCGCTTAGGCTCCGCCCCTCTCTTGGCATTTCGAATTTTTT +CGTTAAATTTTTGGAAACTGAAATTAAGTCCAAAAAGAACCAAGAAACGG +GCGGAGCCTATTATGGGATTGAAAAGACATGGTGCATCGATATGGAAACG +GCTTTTAATTTGGTTTTTTTTAAATAAGAAACTAGTAAAATTCAAGTGGC +CTAGCTTTCAACTCTTCCATAATTCCAGGGTACATTCCAACTGGTCATTG +CTCATTGCTCTCTCTTTATGCTTCTCATCACCAACGAATCCACTCAATTT +TCACTCAAGCTGTCATCTCCAGCAGTGTCTCTCAATTTAATTATGCTTGA +AATTGTTTTATAAAATGAAACAACACATACTCTGTAAAAGCAATTTATTA +TTAAAAAGTATATATATACACGTATTCCTGGGTGGGTATTGAGACTAACG +GAAGCGACATGGAGGAGAATTTGAATTTCATTAAAAAAAAAAAACAAAGA +GGTAGGTTACTGTAGCATCCAATCTGGAGGCTGCACAAAGAAGACTCCAC +CGTCAGTGGCGCAATATGTTGGACACACCTGGAACGTTGAAACATTATTT +ATTTCTTTAAAATTTTCTTTGTCTAAGCCTGAGCCTAAGCCTGAGCCTAA +GCCTAAGTCTAAGCCTAAGCCTAAGACTAAGCCTAAGCCTGAACCTAACC +CTAGGCCTAAGCCTAAGAAAAAGCCTAAGCTTGAGCCTAAGCCTAAGCCT +AAGCTAAAGCCAAAACCTAAGCCTAAGCCTAAGCCTAAACCTAAACCTAA +ACCTAAGCCCGAGCTTAAACCTGAGCCGATACCTAAGCCTAAGCCTAAGC +CTATTCCTAAGCTTAAATATAAACCTAAACCTAAGCCTAAGCCTAAGCCA +AGCGCTGAGCGTAACTTAGAGCCTAAGCTGAGCCTGAGCCTAAAACTAAG +CCTAAGCCTAAGCTTGATCTTAAGCTTAAACCTAAGCCCTGAAAATTTTT +TTTTGAACTCCACAACAAAATTTGTAGAATGTTTTTAAAAATTGGGATTC +TGAAATTCCCCGCCAAAAAGTTTAAAAACTTCACATTTTAATTTATCTGT +AAAATTTATATAAATCCCTCTTAGATTTTGAATTTCGCGGCAAAACTTGT +AGAACATTTCAAAAATTTACTTTCGCGCCAAAGATTGTCGCGCGAAATTT +ACAATTTTTCTATAAAAAATGTATTTCATAGAATTTCAAAAAATCGAAAA +TCGCGCCAAAAATTTTTAAAAATTTTTTTCAGTATTGTGACGTCATAGAC +TACAAACTAACCCCTCTATTGCCTTCCTCCCCGTGCTCTCCAATGAGTCC +TTCGGCTCCAGCGGCTCCATCATTCCCTGGGAACCCGGGCTTTCCTTTTT +TTCCTCGTGGGCCTTGTGCACCAATCGGGCCGTCGATACCAGGCATACCA +GACGGTCCTGGCGGCCCGAATTCTCCTTCCTCTCCGATCGGACCTGCTGG +TCCCGGGATGAACGGTTTCGGGGTGGCGTCCGCACCCGGGTCGCCCATTT +CTCCATCCAGTCCTGGGATTCCCTGAGGGCCTTGTAGGCCTTTTGGTCCC +ATTTTTCCATTTTCCGCGCGAAGTCCATTCTTTCCGGGTAGTCCTGGCTT +ACCAGTGTCTCCTTTCACTCCCTGAAAATTTAGTTTAGTGGTATAGGCCT +ATCAAATAGGCTTACCGTAATCCCAGTGGTTCCTTGTACTCCTCTCGGAC +ACGGATCCGCACACAAAGACTTATAATTCACAGGAGGCTCACATGGTAGG +CGCGCTGGAAGTCCAGGCGCACCTTCCGATCCTTTCGTTCCAGGAAGACC +GTCTCTTCCAGGGATCCCCGGGGGTCCTTGTGGATGACGGCACTCACATA +CTCGGGATCTTGCGGTTTGGCCGGTTTCGTGTAGGAAATCGTCGATTTCA +TCTCTTTTCTGGCGGGTTATGTTTTGGAAATCGTTGGCGACATCGGATAG +CATGCTTTTCATCTCGAGGGCGCTTTCCTGGAAATTTAAATTTGCTTGAA +ATTTTCAAACTTGTTATATTATAATTTACAAAATACTGACTGCCTTTGTA +AGTTTTTTATTACAGGAACACAAAATTCTAAGAATGCGTACTGCACACTA +TATTTGACGTGCAAGATATCTCGTAGCAAAATCTACAGTAACTCTTAAAA +TGACTACTGTAGCGCTTGTGTCGATTTACGGGCTCGATTTTCGCAACTTT +TTTTCTTTCGGATTTCCTTCGTTTCCTCGTATTGTTTTCTAACTTTTTAT +TTCAAAATTTCAATATTCTATCGATAAATAAATCATTTTAATTTATTTCG +AAAATCGAGCCCGTAAATCGACACAAGCGCTACACGAGTCATTTAAAGGA +TTACTGTAGTTTTCGCTACGAGATATTTTGCGCGTCAAACATGTTGTGCA +ATACGCATTCTCAGAATTTTGTGTTTCTCTAATACTGTGTTTTTAGGATT +TTGAATGAAAGGAAAAGCCCGAAACTTTTAAACAAATTTTTCGGTGCATT +CTGTATCAAAAAAGCTGAATAAAATTGTACAAAAAAATGCCACATTTTAT +TGAAAAATTGATAATAAAATAATTTGTTTTCAAATAATTTTTGAATTTCT +CAATTTTTTGGAATTTTTGGATTTTTTCGGGCCAGAAAGTAGGCATTCTC +ATGAACTGATGTTTTCTTCATAATAATATATTCAAAAAAACGGTCTCCCA +CAAAAAAAGGTCCGAGAGGCGAACAAGGTTGTAAAACGTTGCTATTGTTT +ATTTACAACCGCCATTATACCCCTATAGGGGTTGTAACACCACATAACAA +TTTGATAAGATGCACACAGTAGGGAGAGGGACCTAATTTAAAAATATAAG +AATTTTCTCATTAAATACAATTTTTCTCTATTTCTTTCAGGAATATCGAG +AGGAAAATCAGCGAAATTTTTGGAAATTTTTGGTTTTTTTCTAACGAAAC +AAAAAAAATTTGAAAAATTTCAAGAAATTCTGTGTATTTATCGATAAAAT +TTCAGAAATCAAGGGGGTCGTATAGAAGTTAGACGGTCGGTTTTTCGACT +TTCAGCTAACTTTATGAAATTTCATTTGTTCAGGTTTTCTGACATTTAAA +ATCAAATGGCATTAGCAGTTTTTCATGAAAAGTTTCAGAAAGTCTCAAAA +CTCCAAATTTTAGGAGGGTCGTATAGAAGTTGGACGCACTAAAAAAAAAG +GAAAAATGTGGTTCTAATTATTACGGAAACACTAAATTCTGAGAATGCGT +ATTGCACAAAATATTTGATGCGCAAAACATCTCGTAGCGAAGACTACAGT +AATTCTTTAAATGTCTACTATTGTAGCGATTGTGTCGACACGTGGTGCCA +GATTGTCTCATTTCGGCTTGATCTACGTAGATCTACAAAAAATGCGGGAG +AAGAGACGCAGACTTCTCAACTGATTTCTCATGGTTAGGAACGTGCTGAC +GTCACATGTTTTCGGGCCGAAATTTCCCGCATTTTTTGTAGATCAAACCG +TGATGGGACAGCCTGGCACTATGTGTGTCGATTTACGGGTTTGATTTTTG +AAATTGATTAAAATAATTTAGTTATCGATATTATATTGGAATTAAACAAA +AAGTGAGAAAATAAATCGAGCCCGTAAATCGACACTACAATAGTCATTTA +AAGAATTACTGTAGTTTTCGCCACGAAATATGTTTGCGCGTCAAATATAT +TGCGCAGTACGCATTCTCAGAATCCGTAATCCTCAAACTTCTCACCTGAC +AGTACTCGGCATCGTTGACAGTATTCTGAATAGCCGGTCGAAGTATTGAG +GCAAGGGGTCCTACAGAAACAATAAACGACGACATCGTGGATAGCGAGAT +AAATAGTGAAACTATGATTAACGTGGCGTATGCCGTTTCTCGAGCATTCT +CGTTCATTTTCCAGGAGAAGCCTCCAAGAGAAGCCTATGGAGGATCCAAC +GAAAAGTGAGTAAAGAAATGATGCGCTGGCGCGGAAAAACGAGAGCGATT +ATGTATGGGAGTGACCCAAAAACACGGAAAAGTAACGGATAACAAGAAGA +AGAAGGGGGCAACTTTCTCTTTCTTATCATCATCACCATCATCATTATCT +CCTTTCTCGGGATTCCGTCATGAGAATGAATCCATTTACTCGTTTTTTTT +GTGTCCATTTAAGTTTGTCTATAAATATGGCTAATTTCAACTTTAAAATC +AAATAATGAAACTAGTAATTCTACTCATCTCTCACGCAATTCCTTTCTTT +TATGTGATATATAACTTTTATTCCATATTTAAAGAAATTTCAAGTTTAGA +GTCTAACTTGAAAATTGCCAGTGATGAATATAAAATTAGAATGAAGAATA +TTTCCAGAGAAGTTGGAAGTGTAGTCTTGGAGGAGAAGAGAGGAAAGAGG +TGAGGAAAAATTACGTTTTTTTGAAGTTTTTTCTTTAATTTTCGAAGGAT +TAGGCTTAGGCTTGGGCTTAAGTTTAGGCTTAGGCTTAGGTATAGGCTTA +GGCTTAGGTTCAGGCTTAGGCTTAGGCTTAGGCTTAGGCTCAGGCTTTTG +TTCAGGCTTAGGTTTAGGCTTAGGCTTAGGCTTAAGCTTATGCTTAGGTC +AAAGTATAGGCTAAGAGGCCTAGGCTTAGACTTAGGCATAGGCTTAGGCT +TAGGCTTAGGCTTAATCTTAGGCTTAGGATTAGGCTTAGGCTTAGGCTCA +GGCTGAGGCGTAGGCTTAGACCAAGGCGTAGGCTTAGGCTTAATCTAAGG +CTTAGGTGTCGGCTTAGGCTTTAGCTTAGGCTTAGTCTTAGGCTTAGGTT +AATCTTAGGCTTAGGATTAGGCTCAGGCTTAGGCTGCGGCCTGGGTTTCG +GCTTAGGTATAGGCTTAGACTGAAGCTTAGACTTAGGTTTGGGCCTAGAA +TTAGGCTTAGGCTTAGGCTTAGGCTTGGGCGGGGCTGGGCGGATGAGAAA +AAGAGAAAAATTCCAGGAAAATCCAAATAAAATCCAGAAAAAATAATAAA +AAAAAGGAAAAAACGGGAAAAATGGGGCATTCCGCGTCTGCCGCGTCAAA +AACTTTTCCTTAAAAAACGGACAGAGAAGGACCAAAAAAGACAAAAGTTT +AACAAAAAATAGTTAAACATTTTTTTTGACGGGGTTGAGCTCACCCAGCT +GAGCTCACTCCATAATTGCACACAAAATTCTCAAAAAATTAATTTTAGAG +ACTACACAGAGGCTAGCAAATGCACATGCTCTTCAACGATTTCTCAGAAA +TGCCCGCCAGGCTCCAAAGGTGCTCCAGGAGCCGATGGTCTGGACGGGAT +CCCCGGCTCCAGAGGTCTGAATGGTATGGATGGAGAGGCTGGGCACAGTA +ATATGGATGTTTGTGAGTTGCCCAAGATCTTTTATTTTTTGTAAATTCAT +ATTCCAGTCATGTCACCAACAGGATGCATCCGTTGCCCAGCGGGTCCTCC +AGGTTCTCCTGGTGATCATGGTTCTCCTGGTGAACCAGGGTACCCGGGAC +CTTCAGGACCTCCAGGGGAACCCGGTTACGCAACAATTGGGCTTATCGGG +CCACCTGGACTCGCAGGCCAAGATGGTCTAGATGGAGCTCCTGGCGAGCC +GGGAGTAGGTGGAATGGATGCAGTGAAGATTGTTTCAGTTGATGGAAAAA +TTGGAAGAAGAGGAGAAGCGGGGAACAAAGGAAGCAAAGGATCTCGAGGA +GGAGTTGGAAAAGCTGGAGGGCCTGGGGTGGCTGGAGAAATGGGAGAAAA +AGGAGCAAGAGGTGAAGATGGAAAGCCTGGAGAGTCTGGAAAGGTGAATT +CTCAGAAGTTGATCGATGCACCAGGGCGACAAATTAAGCGAATCGGCAAA +TTGCCGATTTGCCGATTTGCCGGAAACTTTCAATTCCGGCAATTTGCCGG +TTTGCCGATTTGTCGGATATCAAATTTGCCGGAAATGTTTAGAGGGATTT +TTTAAAAGACGAAAACACTTAAAACTGTGTCTTTTTGAATTTTTTCCCGT +TTTCCTAACTAGGGAATATTGTTAATAGGGGAATTGCTAGGAAGAAAAAA +CAAACTTTAAATGACAGATGAGGTCTTTGGCTACAAAAATCATTTTTTTC +ATTATTTTCATTTTCATAGAATTTGCTCACTTTTCAAAATAGACGTAGGA +ACATTCATAGGATGCGTTTAATTTTGCCATTTGAAATTTAAATTCTGAAA +TTTCCAAAAAAAATCGGCAATTTGCCGGTTTGCAGATTTGCCGGAAATTT +TCCATTCTGGCAATTTGCCGATTTGCCGATTTGCCGATTTGCCGGAAACT +TTCAATTCCTGCAATTTGCCGGTTTGCCGATTTTCCGGAAATTTTAATTC +CGGCAATTTGCGGATTGGCCGATTTGCCGGAAATTTCAATTCTGGCAATT +TGCCGGTTTGCCGATTTGCCGGAAATTTCAATTCCGGCAATTTGCCGGTT +TGCCGATTTGCCAAAAATTTTAATTCCGGCAATTTGCCGGTTTGCCGATT +TGCCAAAAATTTTAATTCCGGCAATTTGTCGATTTGCCGATTTGCCGGAA +ATTTCAATTCCGGAAATTTGCCGATTTGCCGGAAATTTAAAATCCGGCAA +TTTTCCAAAACTGTATAATTTTTCAGCCCGGCGCACCTGGAATCCCTGGA +AAAGATGGTACATACTGCCGATGTCCCGATCGAAATCGTTACGATATTTA +TCCATATAAATCGAAAATCTGATAATAGTAATAAAGATAATAATACAATA +AATACAGACAGGAAACGAAAAGCGAGCACTGACGATTGTATGATACCCGA +AACATTAAGGAGGAGCACAAAAAACACAATGAAAAGACACAGAAAAATTG +AAATTTGAAAAACTGGTAACGAGACTAGAATCGTCATGATGATCTTGTTG +AAAAAATTGGAAAAAAATTAAGAATCTAGAAATTGATTAGGCGCAGACTT +GACACGATCTTGGGCACCGAATCCGCATTTCAGGCCAATTTTCGCATGCT +CCGCCTTGAGCCCATGACGGGCAGAGGGAGTCATGATCGATGCATCTGAA +ATGGGGAATATTATTTTTTATTTTAAGCTTCAGGTTTAGGCCTATCGACT +TTGGATCTCAGGCTCAGGTCCTTAAATTGTGTATCTCAAGCTTAGGCTCT +CTCGCTCAAGCCTTTAGATTTCAAATCTTAGCCTTAAGCTCTCCGACTGA +TTTAGGATATCAGACTAAGGGCCTAGGACTTTGGGCCTGAGGCTTAGGCT +AGTATTCAATCTCAAGCTTAGGATCTCACGCTTAAGCTCTCTGACTCAGG +CCCTTAGATTGCAAAAACCTTTGCCTTAGGCTCCCCGACTGATTTAGGAT +ATCAGACTTAGGGCCTAGGACTTCGGGCCTGAAGCTTAGGCTCTCAGATT +CAGGCCCTCAGACTTTGAGTCTAAGGCCGTTAGACTACGATTTTCAAGCT +TACAATTAGGCTTTTAGGCTTAAAATCAAAATCCAATTTAGTTTTTTAAA +AATAATCAAACATTTCTAAACCGCAATTTTTTAAAAATTACCCTAAATAT +TTCAAATTTTAGGCTTAGACTGTCAGACTTAAACCTTTAAACTTTTGGTC +TCAAATTTAGCCTACAAGTCTGTGGACCTAAGACTTTGGACCTCGAACTG +CGGCCCTTAGATCTCATGCTTGGGCTCTAATATCCTGGCCCTCTAGTCCT +AAATCTTTTGATCGTAGTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCT +TTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTT +CAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCA +GGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGG +CTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAAGCTTTCAGGGT +TTCAGGGTTTCAGGCTTTTAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTT +CAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCA +GGCTTTCAGGCTTTCAAACTTTCAGGCTTTCAGGCTTTCAGACTTTCAGG +CTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGGCT +TTCAGGCTTTCAGGCTTTCAAGCTTTCAGGCTTTCAGGCTTTCAGGCTTT +CAGGCTTTCAGGCTTTCAGGCTTTCAAACTTTCAGGCTTTCAAACTTTCA +GGCTTTCAGGCTTTCAGACTTTCAGGCTTTCAGGCTTTCAGGCTTTCAGG +CTTTCAGACCACAACTAGACCGGCAACACACGTGTTGTCTAATTACTCAC +CTCTTTGCCGGCGCTCTATGCATATTTGATGGTAACTCGATTGTCTTTGA +AGCTATCACTTTCACAGCTTCCCAAGTTTCCCGAGCTGTTGGAATGATCT +GAAACATCAAAAATCATCATCAAAAATCGTGGTGAGACCCAAAATTACCT +GATTCTCAGCCAGCAAGAATCCATCCCAAACTTGCTCTTCGGGTCTCAAC +TCGAACAGGAATGAGTACTTGACGTGGGCTTTTCCCTTTGCCCAATCTTC +TGAGCCACCGGATGCGGGGTCTGGAAATATTTTGAAATTTTATACATAGG +AGCCTTAAGAAATAAGAGCTTACAAAGTGTATCTGCACCGGTTCCAACTT +TGTACTGCGTGTTGTAGACACTATTCAAAGCCTGAGCTGCTGAGAGGGCA +GTGGATCTCTGAAATGTTTAGAAAATATGACCATGACTTGGGCAAACAAT +TCCCGCATTTTTGTAGATCACACCGTAATGGGATAGCAAAACACGTGGTG +CCAGAGTGTCGCATTTCGTTTTGATCTACGTAGATCTACAAAAAATGCGG +GAACTGATTTCTCATGGTTAAGAACGTGCTGACGACAAATTTTTTTGAGC +GAAAAATTCCCGCATTTTTTTGTAGATCAAACCGTAATGGGACAGCCAGG +TACCAAGTAAAAAATTTACTCACCAAATCATTCAAATCATTTGAATAAGT +TCTGACTTGATGGCCGAACGGATACATCAAAATTTGAGAGTACGAGTGGA +AGGTGAGGAATGTCGAAATACGGTGTCGCTGCACGAAATCTCTAACCGCC +GCAGTCTCGGGCTCCGAGAAGGCGTAGGCTCCCTGATAGATTTCCGAGCA +AGGATCAGTTGATGAGCCGACTTGTCCGAAGAACCAGTCAAAGTTTCGAT +TGAGGTCGACACCTTGACAGCAGGTTGTTGTGGGAGGTTGGAAGAGTCCT +GAAAGGTTTTTATTTTTGAGATTTTTAACTTTCACGGAGAATTGCCAAAA +TCTTAGTTTTCATAGCCTGTGTGACATTATTTGGGCGTAACTAAAGTCCA +GAAAGCTTATGCCTTGTGCTGATGAATTTTTGCAAAAATTGTGCCCAGTT +TTGCCACTTTTTAGTGGTTTTTGATGGGTTAAACCTAAATTTTCTGAATT +CAAGTTTTTATTTTTTCCAAATGTTTTTTCAGCCATCGAATGGCTGTCCT +TTTTTTCGGGCAAAAAAATAATTTTTCTGAAACTATTTGAAACAATTATA +TTCTAAAAAAAAGGCAATTTTTTAAATTTTTTCTAGTAAATTTTGAGTCC +TCTAGCTACAAAATAAACCATTTTAGATGAGTTTCAAAAATGTGCATTTC +TACAAAAATTGCCCAATTTTTGCCACTTTTTGGTGGTTTTTGATGGGTTA +AACCTAGATTTTCTGAATTCTGCGTATATAAATTACACGTTTTCAACAAA +TTTAGACATTTTTTTTATTTTTGCCCAATTTTTTTCCAGCCATCTAATGA +ATATCCTTGTTTTTAAGCAAAAAAAAATTTCTGAAACACAATTATTATGA +TCCAAAACAGGGGTGTGCGGCAAATCTCAAAATTTGCCGAGCACGGCGAA +TTTGGCAAACGGCAAATTTGGCAAATTCAGCAAATTTGCTGAGCTTTACA +AACTCCGCAAAAATTTGATACTTTTTGAAGCACCTAAACTACTAATTTCT +GAACAAAAGTTCAAAATAACTTGATTTTGTGCCATTTTTCTAAATTTTTG +GAAATCAATAATTTTGTCAATAATTTTGGTTAAAATTGTATTGTCAAATT +TTTGACGCGGGCGGCAAATTTCAAAAATTTCTGAGCTCGGCAAACGGCAA +ATTCGGCAAATTTGTCAAATTTGCCGCACATTTTTTTTTGGTTCAAAACA +TAATAAAACACTCCAAAACATTTTAGATTTTTCATAATTTCCGGTCGAAG +TTTTTGCAAATTGCTAAAATTTTGAAAAATATGAGTATTTGAGGAAATCC +AAAGCAATGCCGCATGTTCCGACCCCTACAATGTTTTAATACAAATGATT +AAAACAAAATTACAGTAGACAAAATGTAGAAAAAAAATTATTTTTGGTCG +ACTTCCAAAATTATGAGTGGCAAAAACTTTGTAATTGTCACTTTTTGACA +GTAAATAAAAAATTTTAAGAATTTTTTTGAAAAGTTTTATTATGATATTC +GGTCATTTTGGGACCAAATGAGTGGTTTTTAACAATTCCGGCACTGGCGC +TAGTCCAGCAATTGCCGTAATCTTAGTTTTCATAGCCGACATTATGCGGG +CCTAACTGAAGCCCAGAAAGCTTGTTTACAAAAATGAGCAAGCAGAAAAA +GATCAATCTCCCCAACAAACCTGTTGCCTGTTGAATACACTTTGGTGGTG +ATCGATTCTTTCTCCACAGTCTGATCTCCGGATCATTGCTACTTCTACTG +TACTCATAACCATCCGGATTCAGCAGTGGAACAATATACCATTCGAGTTG +ATCTACGAATTGCTTGATTTGAACATCTTTGTCGTACTGGGTGACCAGTT +GGTGAATGAAATAGAGTACTGTCGATGGTGACACCCATTCACGAGCATGG +ATTCCTCCGTCCACCCAGATGCCACGTTTCGTACCTCCGTTACGCTTGTT +GGTGATCTGGAATTGAGGAAAATTGGGGTGAGATGGGATCACTAAATTCT +GAATCTAGTTTCTGTGCTACTGTGTGTTACGTTTTTTGCGCTCCATTGGC +AATCGCCTGCCCATCAAAAACCGTCAAAAAGTGGCAAAACTGGGCAATTT +TTGTAAAAATTCACAATTTTGAAACTCCTCTAAAATGGTTTAGTTCGTAG +CTAGAGGACTTAAAACTGATTTTTGAACCCTAAAAATTGTCTAAATTTGT +TGAAAACGGGTAATTCTTGTATGCTGAATTCAGAAAATCTAGGTTTAACC +CATCAAAAACCATCAAAAAGTGGCAAAAGTGGGCAATTTTTGTAAAAATT +CACAATTTTGAAACTCCTCTAAAATGGGCAATTTTGTAGCTAGAGGACTC +AAAATTAACTTCCAAACTCTAAAGAATTGTCCTTTTTCAGAATATAGTGG +TTTCAATAATTTTCGAACAGAATTTTTTTTGCCCAAAAAAGGATGGCTGA +AAAAAATTTTGGCCGAAAAAAAAACAGTTTTACACTGAAAGCCAAACCGC +GACGCGACACGCAAAGCTCGGTAAATCGACCCCAGCCGTGGCCGAGTTCA +AATAGCCAAATTCGGCAAACTCTCACATTTCAAGCTATGTATTTCAAGCC +AGAAGCGCGTGCGATTTCTCAAAAACCGGCAGCTCAGTTGCAGGAGGACT +TTACGAAAATTTTGAAAATTCCAAGGTATAATTGGTAGGTTTTTCGGCAT +GTTGCATGGTACTTAAAATGTTTTTTTAACTTTCAAAAGTGGCTTTTATT +TTGGTTCTTATTGCAAGCCTAATAATAAAAATACTATCCACGTTTTAAAT +GCTTCCATGGTAGGCAGGCGCGGTTTCAGGGCCGACATGGAAGCCCTACA +TGTCACGGATTTCTGGCTTTCCTCAGAAATTGAAATGGACTAGTTTTTGC +CGAACTAGGCCAGGCCATATCTGGGGTAGATTTACGGCGCGTTGCATGTC +GCGTCGCGGCTCGATTTTAGTTGAACAACTAAATGCATTTGTCCGAGTGG +AGTACACGACTTTCCCACGCGGGCGATTGCCAATGGAGCGCGAAAAATTC +AATGAGGAGGGCCAGAATCCCGTGATCGTCCGAAGCAAAGTTAAAACAAC +AAACCTTAATCAACGGGATCTGCCGTCCTTCGTGAGTCGTTCCGATTGGC +TGCACAGACACAAGCTCCGGATAAGTGATGGCTAATGAGTTCAGGTAGTT +GATAACATCAGCAAACGAGTGATATTGTGCAAGGTTAAATTGAACCTGCA +ATAAGTTATCATTGAACTATGTATCATTGAACGTGGTGTCAGAGTGCCTC +ATTTTGGATTGATCTACGCTGATCTACAAAAAATGCGGGAGAAGAGACTG +ATTTCGAATGGTTAAAAACGTGCTGACGTCACATTCTTTTGGGCTAAAAA +TTCCCGCATTTTTTGTAGATCAAACCCTAATGTGACAGCCTGACACCACA +TGTATTCACTCACTTTCTGCTCCCTCCAATCATGCAGTCGAACTTGTTTC +CGAAGCTTATCCCGCTTCTCCTTCTGCTCGACAATCACTCTGAAATCGAT +GAAAAGATTGTAAGTTGGGCTTAATAGTGTCCCCCCACGACACCCATCAC +GCGTAACGAGCCGTGACGCGTTTGAATAAAGAGGGTATTTGGACTTGTGA +TCCCCGCGAAAACCTGTATCGCACGTGATGCCAGGGTGTCTCATCACGGG +TTGATCTACAAAAAATGCGGGAATTTTTTGCCCAAAAATGTGACGTCAGC +ACGTTCTTAACCATGCCGAATCAGTTCCCGCATTTTTTGTAGATCTACGT +AGATCAAGCCGAAATGACACACTCTAACACCACGTGGTATCGCCGAAAAA +CTCACTTCTGAACGTCATCAATCATAACGGAATGCTTAATCGAATGATCA +TCGAGCTCTTTCATAAACTGCTGAGTTTTCTCATCGGATATCATCACATG +AACCTCCTTGCCAGCTTCCGACGGGGATTTCCAAAAATCTAGCTGAAAAT +TTTAGTGTGTCTGAAGCACCCTTATCAGTTCATATTATATTTCAAAATTT +TTCTCTAACCCCTCAAAACCGTACTCTACATCGCCGTTCTGGCCGAGTGG +TCTAAGGCGCTGCGTTCAGGTCGCAGTCCTCTCCGGAGGGCGCAGGTTCG +AATCCTGCGGACGGCAGATTTCTTTTTTGAATACTACTCTTCAAACAATG +CATGATGAAGAAGAAGAAGAAAAAGAGAAGAACGTATTGGCTTTTCCTTT +TACACTTTTGAAATCCCTAGGAACAGGTTATAAACAGCGATGTAACATGA +AAAGCAGCAGTGAGAGTGATCGAAAACGAGCTGATTATGATTTGTTCAAT +TATATGACACCGCTATTGTAATGGTTGGTTTGTTGCGTGGAACATCATAC +CTTTACATCGTTTAAATACAAATTATGAAGAATGTCTACTTGATCTTGGG +TCGTCGGCTGCACCCTCCATACTGTGAATTTTCTGAAAAATCGAGAGTTT +ACCGGCTTTTGGGGGAGATTTTACCATTGACTTTTGACTTTTTGGAGAGA +TCTAAATCTAGTAGATCATGCGGCGGTTAGGTCTATTTGAAATAAAAAAT +AATTGATCTAGATATGAAACATGGAGATCTAAGGGTTTTGGTAAAGTTGA +GTAGAATTTTTAATTATTTTTTTGAAAATTTGTTTGCAACATTTTACAAA +AAAAGACGAATAAATATTGACCAAAAAAATTTTTTTCAATAAAAAATGTT +TAAAAATTAACCACCTTTTAGCTTTTAAAGGTGGAGTAGCGCCAGTGTGG +ATTTTGTCTAAATACACTTATTATGAACCAAAATGGTCAAATATCATAAT +AAAACACTTCAAAAAATTTCTTTATTTCAGATTTTTCATAATTTCTGGCC +AAACTTTTTGCAAATTTCCAAAATTTTGAATGTCGCAGTTTCCGACCCCT +ACAATGTTTTAATACAAATAATTGAAACAAAATTACAGAATAAAAAATGT +AGAAAAAAAATTTTTTTTTTGGTCGACTTCCAAAATTATGAGTGGCAAAA +ACTTTGTAATTGTCACTTTTTGACAGTAAATAAAAAATTTTAAGAATTTT +TTTGAAAAGTTTTATTATGATATTCGGTCATTTTGGGACCAAATGAGTGG +TTTTTAACAATTTTCCCACTGGCGCTACTCCCCGTTTAAAGTTCTATGCT +TTTTAAAACTCACGTTTTTTTTTATGAAGTCTATTTTAAAAAATCTGGAC +TCTCAGTGGACAGTTCAGCATTTTTCGAAATTTCAGAAATTTAAAACATA +AGTCGGAAGTGGTCCTAAAACTTCAAAAAAATTCTCACAATATGTTTTTT +TGATGAAAACAAACTTATATAGTGCCAAAATGACCAAAATTTTTTTAAAA +ATAATATTGAAAAATCTTTAAAAAATCTCTTCTGGTTTTTATTTATTTTT +AAAAAATTCATATTGAAATATTATAGTGCTTTAGATTGCTCGGAAAAAAT +TCCACAAATTTTTTAATTTTTCATAAGTTTTATAATGATATTTGGTCATT +TTAGCTCTCTCGGGTAATATTGCAAACCCACGTGGTGCCAGGATTTCCCA +TTAAGGTTTGATCTACAAAAAATGCGGGACTTTTGCTTAAAAAGATGTGA +CGTCAGCTCATTTTTAACCATGCGAAATCAGTTGAAAACTCTGCCGCATT +TTTTGTAGATCTACGTAGATCAAACCGAAATGAGACATTCTGACACCGTG +TCCACCTTCAAAGTTAGTAATTGCATGAACAAAAAATTCTGAGAATGCGT +ATTGCACAACATATTTGACGCGCAAAATATCTCGTTGCGAAAACTACAGT +AATTCTTTAAATTACTACTGTAGGTCGATTTGCAGGCTGGATTTTTTGAA +AAAAAAATGAATTAAAATTTAATGGAATATTTCTATCTCTATGTATTAGA +AAATAAGGCCCGTAATGAGACGAGCGGGCCTGCCTACCTGCCTGACTATA +GAAGGCCGCCTTAAAATCAGGCAGGTAGGTTTTAACGCCTAGCCTACAAT +AAACATAAAGAGAAATGCCTAAAATAACAATAACTTTCCATTATCCTTTC +TTATCGTCCTCCCCGGCGATCGCCTAAGATCATAGATAACAACTAGCCGC +TTTCGGTCATGCAATTATTATATTATAATTGATGGATGGATGGGGGATAA +TCCAGAGAAAGGGGAAAAAGAAACTTAGAATCCTAGAAAACAGGTTCCCC +TGACTCAAACAAAAAAACCTACTTTTGATGTGCCAACACGGATGGCACGA +CGAGACCGATGAGGACGATGATGTTCATCATCATCATCTTCATCGTAGTA +AAACTTGGGGGGTGATGAGGGGCAAAAGGATGCCCTCCGCGCGTCAAGTG +TTCGTTGAACAATCCGACGCAGACGGTTAAACAAAGCAACACAGTGGTGT +CTCCGCCCAACTTCCGCGCGTCCGCCGCCGCCCTGTGTACTGTCTTGTCC +TATCCTATCTCTCTTTTCTCCACCCCGGCTTGTGTGTGAGATTCTTCTCA +TTACTAGAAGAAGGTCTCTAGTAGAAGAAGAAGAAGAAGAAGAAGACGAC +GATGGAGAAGAAGCTGAAGGCACGACGCACTGTTTGCGCAACGATGTTTG +TTTTTGCGCGCGCGAGCGCCGCATTTAAAACGTGTAAATCGGTTTCAAAA +GCGCGCGCGCGCGGTCTTCTTTCTCCGCTTGCGCGCACGCATTGACAAAA +AACCGAAAGGTGCAAAAGTGAAGAGGCCAACTACTTTCGTCCTCTTTGAG +CACCTAATTGTGGAAAGCTTTTGCTCTGATGTGAAATGAAGTTGGGTAAG +CTATTCCTGTCTGGGTGATGTTTTCAACTTCCGGGGGCATTGTTGGGAAA +GTGAGGACCAAAATAGGCCATAAAAAATGAAGATATACATGCTTAGGCTT +AGGCTTAGGCTAGGCTTAGGCTCAGATTCAGGCTTAGGCTTAGGCTTAGG +CTTAGGCTTGGAATTAGGCTTGGCGTCAGTGGCGAGCGTGAGCTCGCCAC +TGACGCTATTTAAGCTTGGGTTTATAGCGTTTTTTTAATTTTTCAAAGGG +TTCCCGTCTGCCGATCAAAGCGAAATTTAACAGAGAGTCGTATAGGCCGC +CAAGAAGCTGAAGTTTCAAATTGATTTCATTAAAACTCGCTTAGGCTTAG +GCTTAGGCTTAGGCTTAGGCTTACGTTTTAGCCATATGCTAGCTGATCCG +GAACATATTTTTAAAAATTGCAATATTTGACCAAAAGCTGTATTTTTCAA +AAATTCAAAAGTACGGTGAAATCATATGAAGTGCTTCTTTTTCTTTCATT +AAACTGTTCAGAATTGTCATTTTTACTAGAAAATACCAAAAAAATATGCT +AGCTTGACCGGAACATATTTTAAAAAATTAGAATTTTTGACCAAAAGCTG +TTTTTTCAAAAATTGAAAAGTACTGGAAAATCATATGAAGTGCTTCTTTT +TTCTTTCGTAAAACTGTTCAGAATTGTCATTTATACCAGAATATATTAAA +CAAAGTATGCTACCTAATCCGGAACATTTGTTTCCAAAATATTTTAAAAA +AAAGATTTAGCGGCTCTGACTAAATTGTTTGTTCGTTTTTTCTGGACCCT +TTTTTCCCCTTTTTTTGGGTGAAAAATTTTGTAAAAAATTTGACCGAGGT +GTAGAGTTGAATTCATCAATTTTTGACATTTTTTGAGTACGGGCACATGA +AAACGAAATTTCCAAAAACGCTTATTTCTCGGGATATAGTTCAATTCTAC +CAAATTTTTCTTTGCAAATCTGCTAATTCTACAAATCTACTAACCGAGGT +GTAGAGTTGAACTCATTTCCAAAAAGAAGTAGCAGTCCTGAAAATGTTTT +AGTGAGTCTTCTCATTACTCTAGAGCCCGAGCCAGTAAAATTGCTCCAGA +AGTAGTAATTTATAAATTTTTGATGATTTTATGCTGTCCAATGATAGAGA +AATTGTTAAAATTTTCAGATCAAATTGGAATTTTCACAGCCAAATATTTT +GGAAAATTTTCCACAAAAAATTGGGCGGAAAATTGGAATATTAATTCGAT +TTAATTCGATTTGGAGCAGTGTATAAATTCAAAGTTTCCTCCCTTAACAG +CCATTCAAATGCACTTTTTTCTTCGTTTAGTTTTTCTTATATATGGCCTC +CAGGCTCTCACCAAGTTCCGTTTTACCGGAGAGTTTAAGTGCAAACATAA +ATTCCTGAGATCCCATGTTGTAGTTTATGAAGACGATGAGGTGTTGTGAG +TAGAAATGAAAAATGAGAAATGTTGTATTTAATATTATAAATTGTTTCAG +CGACAACGTTATCAGTAAACACCATTACGTGTTCCATACAAATGCACCAC +ATATGTATCTCGTTGAGGCTGAAGATACCAATGACGGATTGCCAAAGTTT +TTGGATGTATTACTTTTTAATTTCCCGCTTTTTCTCTAGTATTTCTCAGA +AAATTTGAATTTCCCGCCAAAATTTTTTATCAGAAAATTTGAATTTCCCA +CCAAAATTTTTTATCAGAAGATTTGAATTTCCCACCAAAATTTTTTCTCA +GAAAATTTGAATTTCCCACCAAAATTTTTTCTCAGAAAACTTGAAATTCC +CGCCAAAAACTTTTTCTCAGAATTTTGAAATTCCCGCTAAAAAATGTTTC +TCAGAAAATTTGAAATTCCCGCTAAAAAATTTTTCTCAGAAAATTAAAAA +TCCCCGCCAAAACTTTTTCTCAGAGAATTTGAATTTGCCGCCAAAAAATT +GTTTTCTCATAAAATCTGAATTTCCCACCAAAATTTTTTCTCAGAAAATT +TGAAATTCCCGCTAAAAAATTTTTCTCAGAAAATTTGAATTTCCCGCCAA +AAAATTGTTTTCTCATAAAATCTGAATTTCCCACCAAAATTTTTTCTCAG +AAAATTTGAAATTCCCGCCAAAAAGTGAACATTCTAGGAGTTTGGCAGTT +TACCAAAACCTTGACTGACCATTTTGGAAAATCGAATAACCTCTTAAATA +AAAACTCTAACTTGTAAAAATTTAAAAATTTAAATATATAGCTTTGCAGT +CCTATTTCGAGTTATACATGATCATCGTCCACGATTGCACGGATAATGGG +AAATACAAGTTGTTGACAGTTGACTTGGGATCTTATTATATCAAGGATGG +GTAGGTACTTTCTACAGGGCAGGCTAGGGCTTCCATGGGAAGCAGGAGCG +GTTTGCCGGCTTCTCGCCTGATTCCTGCACTTTGGCAAAAAGTCAAAGCC +TCGATGCTCACACATAGGGCTGGCATATTGGACGTCCGGTTTTTTGAAAT +TTTAAATTTTTCCGAGAGGTAGTTTTTTTTGTACGGCGGCCGACAATTTC +CGAGTTTGGCCACTCATGATAAAATTATATGATTAAGTATAGTGAGTGGC +CAAACTCGGAAGTTGTCGGCCGCCGTAAAAAAAACTACCTCTCGGAAAAT +TTTAACATTTCAAAAAACCGGACGACCGGACGCCCAATATGTCAGCCCTA +CTCACACCAAATAGTACTATAAGCGGTTTTTTTTGCCGCAGCCGACACTT +TACGGTTTCCACGCCGCACTGTACAGAAGGCGCGGCCCGAGGCAGTTGTC +AGGCGTTTTGGCGCCTATATGCAAGCTCTAGGGCAGGCATTTCTGTTTTC +AAAAAAATGAATATTTTCAGGCAGTACGATGAAACACGCAACATTGATCT +GAACAATGCCGGTGAATGGACAAACGAAGTAATCGGAACAAAGGCGATGG +TGATGTCCAAGATATTTATTTTCAATGTTTGATAAAATTGTTCATCAATA +TTCGAGCCTACCTGCCTACCTGCCTACAAGGTAGCCTACATATATTATTT +TTCCTAATTAACAAAAATATAATTAAAACATGATTAAGATTTTCTGAAAA +TGAGCAAAAAGTGTTTTTAACTTCCACTTTTTGCCCAACAGGTTTAAGAT +AGGCATGTGACAAAGCCTACATTCAAGGCAACCTACGCCTGCCTCGGTAC +ATGGTGCATCGACCAATATTTACCTCTTAGCTTCGAGAGCTTATATCTCG +GTTACATTTTGCTCTATCAAAAAATGGCCAACTGAAAAACTGTTCTCCAA +TGCTTTTTCTACAATTTTGTGGTTAAAATTTTTTTAATATCTTGAAAACT +AGCGAAAATATAAGCCACCAAGTCGCGCGCCGCCCCCCGAGAAAGCAATT +CCAACCCAAGTTTATTGCAATAAAAACCAGTAGAAACGAAAGAAATGAGG +TTGATTTTGGAGACTTTTCAGGTGACACGGGGAGCTTTTACATTGTTGGC +ATTATTCAGATTCGATTGAGAAGGAGAAGTCGTGGGGAGGCTGAAAAATG +TTCTAAAGTTGTTGAAAAAAAAAACAAATCTGCATTTTTTAAAAACCTGA +TTCTTAGACTTCCATCCATTGCCATAAGTGCACAGAACAGTCTGTTGCTC +TTGCTCTTTGTGCTCCGTGTCCTCGGAGCCATCATCAACCTTGTCTGGAA +CTGTCGGTGTTGGCTCAGTTGACGGAGCAAATGAGGAGGATGGTGTCGCA +GATTCTTCAGTTGGTTTGGGAGATGATGGCGGAGCTGGCTGAGGTGGAAT +TGGAGATGCTCTTTTTTTTGGGGTTACTGCAGACTGTTTGCTCTTCAAAC +TCTTGCTCCGCGATTTTGTGCTCTTTTTTGTTTTCTTCTTTGGCTGCTTT +TGTTGCTTCTTGCTTTTTATCTGAAAATTAGAGTTTCTAGGCAATCAAGC +GATTTTCTAGGCCACCAGACATATATTTAGCCATGTCGGAATTTTCTAGG +CCATCACAGACAGTTCTAGGCCATATAGAAATTTTCCTAGGCCACCTAAA +ACTTTTCTAGGCCACCAACAGTTTTCTATGACCGCGATTTTTGCTAGGCC +ACCAACAAAAGCAAATAACACATTTTCTAGGCCACCAACAGAATTTCAAA +TTTTTCTAGGCCTTTAACTCACATATTTCACAATGGAAGCGGCGGCGAAC +ACGATGAAGGCTACAATGAGAATGCCAATAATTATGAATATCACTACTTT +GGTCCATGGCGTCGATGATGCTGCAAAAATGGAGGTACAAATATGCAAAC +GCGCTCTACCGCACTACCAGTGCGGTAGAGCGCGTTTCAAACTAACAGCC +AGAAGTTGGCGCCGGTGGTCGCTGAGTGGAGGTGGACATTATCAGGAAAT +GAATGAGAAAATGGAGAAATTTGGGAAAATTGATTAGAGACGTGGGATTT +TTTTTTAATTTTTATAATATTTTTGAGTAGGGGGAAGGGGTGAGGGTCAC +GGAAAATACCAAAAATTTGTGATTTTTCCATTAAATTGGAGCAAAATTGA +CACCATACCTCGTGGCCTAGAAAACTGCAGAATTTCTAGGCCACACACGT +TACGTCATAATTTACCTGTTAAACCAGGTAACCAACAATCAAATCAAGAG +TAATTAATCATCTCCTATCTTCTTTTATTTCTCCGTTCCTACTCCCAATG +TTTTTTTTTTGTAATTTGTGATCACAAATTGTTGCATTTTGTAGTACGCC +ATGTACGTCTGTGTACTACTTTTTTCTGAAAAGAATACAAAAATGTTCGC +TTTCAGGAAAAAATAGTGAGAGGTAGAAGAAAATTACGGGGACTAGAAAT +ATGTAAAAGTTCGACAACGTAGGCAGGTAGGCAGGTAGGCAAGTAGGCAG +TTAGGCAGGTAGGCAGGTAGGTAGGCAGGATAGTAGGCTGCCAGGCATAA +TAAAGATGCAGGCACGTAGGCGGATGTTGCAGGCATGAGAAGTCACGGGG +GTAGGCAGGCATGTGGGTATGTAAGCAGATGTAGGTATGTTGCAGTCATG +ATGAAGGCACGTGGGTAGGTAGGTAACTAGTTAGGCTGGTAGGGAGGTAG +ACAGGTAGGCAGGCAGGCAGACGCGTAGGAAGAGTTAGCCAGGATGCAGG +CACGTAGGCAGATGTAGGTATGTTGCAGGCATGCTGAAGTCACGTGGGTA +GGCAGATTGGTAGATGTGTACGCAGAGTAGGTATGTTGCGGGTATTATGA +AGGCACGTGAGTAGGTAAGCAGGCAGGTAGGTAGGCAGGCAGGTAGGTAG +ACATGTAAATATGCAGGCATATACGTAGGGAGAACAAGCCATAATTCAGG +CACGTAGGCAGATTTAGGTATGTTGTAGGCATGATGACGTAACGTGGGTA +GGCAGATAGGCAGGTAGGCAGGCTCGTAAGCTGGCAGGCATAATAAAGAC +ACATAAGCAGGCATGTAAATCTGCAGGCAGATACGTAGGAAGAGCAAGCC +AGGATGCAGGCACGTAGGCAGATGTAGGTATGTTACAGGCATGATGAAGG +CACGTGGGTAGGCAGGTAGGTAGGCAGCCAGGCAGGATCGGAGGTTGGTA +AGCATAAAAAAGACAGGTAGGCGGGTAGGCAAGCATGTAAATGTGCAGGC +AGATACGTAGAAAGAGCAAGCCAGGATGCAGGCACGTAGGCAGATGTAGG +CATGTTGCAGGCATGATGAAGGCACGTGAGTAGGTATGCAGGGAGGTAGG +TAGGCAGGCATGCAGGCACATAGGCAGATGTAGGTATGATTCAGGTAGGC +AGGCAGGTAGGAAGACTGAATGCAGGCGTGTTGCTAGGCAATAGCGCCCT +TTCCTTGTTATGACAATCTCGATAATCTAATAATAAGCTATTCAATCATA +TCACTGCGCCGATACACAAACTACCTGTTTTTTTGAGTATGCGTCTCGTC +CCGTCTGCCCAAAAGCTTCTACAGAGTGATTAGACGGTATAAGGGGGAGA +GATAGGATAGATTTCAATCATTCTCACTTTTTTCGTCCCTTTCTCTGTCT +TCCTTCTCCCTTTTTTTACAGGGCGCTTTTCCCTTTTTCGTGTGTGTGAA +GAGAGAGAGTGCATACAGGTGTAGAGGACGCCCAGACATCGAGACGGAAC +AGGATTCTTCATCGTCTTCAGCTATTTGGAAGAAGGAGTAGAAGGTGACG +GTGTGTGTTTGGAGACGTGTAATCATCATGTCTTATAACACTTCCTTGCT +CATTTTTCTCTGCTTCTCTGCCGTCTCTCTATCCACACAGTCTTTCGCCG +TTTATCGATTATTACCCAAATCACAGACGGATTTTCAAGCTATACAGAGG +TTATACAAAAATGCGACGGATCATGATGTGAGTTTTGTTTTCGCATTTTT +GAGCAGATACAATTTCTAGGCCACGAAAAATTTTTCTAGGCCGTTGAAAA +AATCACTAAGTTTTCTAGGTCACAATTTTGAGCAAGTTCTAGGTTATTAG +ATTATTACGCCATGGTGCATTTTTCTAGGCCATCAGGAAATTTTGCAGGC +CACCATGAGTTTTTGATGCAGTTGAACTAAGTTAGTGGCCTAGAAAAACC +TTTGTTAGCCTAGAAATATTTTCGCCGGCCTAAACACATTTTTGGTGGCC +TAGAAACACTAACTTTTGGTAGCCTAAAAATTTTCTGTGACCTGGAAACA +TTGTTGGTGGCCTGAAAACATTTTTGGAGGCTTAGAAATATTCTTGGCAA +TTTGAAAACATTTTTGGTGGCCTAGAAATATTTCTGATGGCCTAGAATGT +TTTTGTGGTCTATAAATAATTTTGGCGGCCTAAAAAAATTTGGAATGGCT +TAGCAAAATTTTTTTGGTGGTCTACAGCCATTTTTAACGACCAAGAAACA +TTTTTGGTGGCCTGAAAACATTTTTGGTGGCCTAGAAACATTCTTGGTGG +CCTGAAAAAACATTTTCGGTGGCCTAGAACCATTTTTGGAGACCTGGAAA +TGTTTTGGTGGCCTAGAATATTTTTGGTGGCCTAGAATATTTTTGTTGGT +CTAGAAATATTTCTGATGGTCTAGAATGTTTTTGTGGTCTATAAATAATT +TTGGTGGCCTAGAAATATTCTTGGAGACCTGATAACATTTTTGGTGACCT +ATAAATATTTTTGACAGCCTAAAAATTTTCGGTGGCCTAGAAATATTTCT +GATGGCCTATAATGTTTTTGTGGTCTATAAATATTTTTAATGACCTAGAA +ACATTTTTGGTGGCCTTGAAACATTCTTGGTGGCCTAGAAATGTTTTTGG +TTTCCTAGAAACATTCTTGGAGACCTGAAAACATTTTTGGTGGCCTAGAG +ACATTTTTAATGGCCTAGACACATTTTTGGTGGCCTAGAAATGTTGCTGA +TGGCCTATAATGTTTTTGTGGTCTATAAGTATTTTCGGTGGCCTAAAATA +TTTTTGGTGACCTAAAACATTTTTGGAGACCTGGAAATGTTTTGATGGCC +TAGAAATATTTGTGCTGTGCTGAAACATTGTCGGTGGCCTAGAAATATTC +TTGGAGACCTGAAAACATTTTTGGTGGCCTAGAAAAATTTTTAGTGACCT +AAAAACTTTGGGAATTACCTGGAACCAATTTTGGCGACCTAGAAAAATTT +TCCGTGGCCTAAAAATTCCCAATAATTAACAAATTTTTAGTTAAACTTCT +GGAAAACGGGCAAGGACAAGCACGGGTTTTGGGATGTGATGGTGGATATG +AAGAATTCGAAATATTTTTTGGACTTTCTACAAGTAAATGATATTTCTTA +CATAAAGACGATTGATGACGTGGAGGGGTGAGCTTTTTCTGAAATTTTGA +AAATTACATAAAGAATATGTGCTCTATTGATAAACTGTTAGGATCACCGT +AAATCGACAAGAATCTCCGTAAATCCACAACGGCCCCATCTCAAAAATTC +CTAGGCCACACGTGTGACGTCATTTTTCTTCCAGATTAATAACAAAGCAC +GAGAACAACAAGACCCTCTCGAACATGTTCCCCCGTCTGTGGGATGACTC +CTCGTCTGCTCACTATGACTTCCACACCTATGGATCCTATCAGCGAATGA +CTGATTGGATGAAGCAGCTGGTGGTGAAGTATCCAAAGATGGTTCAGTAT +ATATCGATTGGAAAAACTACGGAGGGCAGGAATATCGATGGAGTTGAGGT +AGGTCTAGAAGGCTGCCTTAGGTCTAGGTCTAAGTCTAGGTTTAGGTCTA +GGTCTAAGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGG +TCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTC +TAGGTCTAGGTCTAGGTCTAGGTTTAGGTCTAGGTCTAGGTCTAGGTCTA +GGTCTAGGTCTAGGTCTAGGTCTAGGTCTATGTCTAGGTCTAGGTCTAGG +TCTAGGTCTAGGTCTAGGTCTAGGTCTAGATCTAGGTCTAGGTCTAGGTC +TAGGTCTAGGTCTAGGTCTATGTCTAGGTCTAGGTCTAGGTCTAGGTCTA +GGTCTAGGCCGATTTCGATTTCTATGTGTATGGCCTATAGTGATTTTCAG +ATCGGCGGAGACTCCCGCACCAAAAAGATTTTCTGGATCGATGGAGGTAT +TCATGCTCGAGAATGGGCGGCCCCGCACACGGCTCTCTTTTTCATCCATC +AGGTATGTGATCCCGCCCCGTCAGAAAAAAGTGTGTTCCGATTAGTTCCG +CTTGGATTACACAAATGTTGGCAGAGACAGAAAAAGGGAAAACTTGATAA +CAAATGGGTTGGAAAAAACGTAATCGGATGATGCAATCGCGCTCTATTGC +ACTACCTCAACAAAACATTTTTTTGCAGCTTACCTCCCGCGCAAACGAGC +CCGGAATCAAGAAATTGCTGAACGAGATCACATTTGTAGTGGTTCCCTGC +TTGAATCCAGATGGCTATGAGTTCACGAGATCCTCCACAAATCCACATGT +AGGTTGGGGTAAGGTTACTGTACCCCCCCCCCCCCCCCTCCCCAACTCAA +AGGCGCAAGCACTCCCAAATTTTTTGCAGGTTCGTCTGTGGCGTAAGAAT +CGCTCGAAAATGCAATGCCGTAAGGACATTTGGGGACGCAATCGCTGCTG +TCGCGGTGTCGATTTGAATCGTAATTTCGATTTCCACTTCAGAGGTGAGA +GAGAGAGGGTGAAGTGGTTTTTCTCAAAGTGGACTTGAAAATTAAGGGTC +AAAGTTTTAAAAGAAAACTTTGAAAAAAACTTGGGAATTTGTTCACGAAT +ATACGAAGTTGCTGAAAATTTGTAAAACGTTTTGGAACATTCTAAAACTA +TTTGAATTTAAATAATTTTTTAAACATACCAAAAAATCATGGATGTTCTC +AAAATTCACGAAAGTTTCGAAAATTCCCTACAGTACTCCTGAACTAGCCC +TACAGTATCCTTAAAGTACCCTACAGTACCTATACAGAACTCCTGTAGTA +CCCTTACAGTATCCCTAAAGTATCCCTACAGTACCCCTACAGTTTCCCTA +TAGTACCCCTACAGTACTCTCGCAGTATCCATACAGTAGCCCTACAGTAT +CCCTACAGTACCCCTACAGTATTCCTACAGTACCCCTACAGTAGCCCTAC +AGTACCCCAGTAGCACCCTTACAGCATCCCTAAATTATCCCTAAATTATC +CCTACAGTACCCCTACAGTACCCCTACAGTACCCCTACAGCATCTCCATA +GTACCCCTATAGTAGCCCTACAGTATCCCTACAGTTCCCACACAGCCCTT +ATAGTGCCTATACAGAACCCCTATAATACCCCATACAATACACCTACAGT +ACCCCTACAGTATCCGTAAATTACCCCTATAGTACCCCTACAGTACCCTG +ACGGTACTCCTACAGCACCCCTACAGGACCCCTATAACATCCCTACAGTA +CCCCTGCAGTACCCATACGGTTTCCTTACAGTATCCCGTGAGTATCCCAA +CAATACTCTCACAGTACTGCTACAGTACCCCAAAAGTACCCCTACAAAAC +CCCTACAGTACCCCTACAGAACCCTCACGGTACCCTACCGTATCCCTACA +GTACCTGAAGCTCCAAAAATTTCCCCCACTTCCAGAAAGCGGTACAAGCG +ACGACCCGTGCTCCGAGATCTACCAGGGACCCTCTCCATTCAGTGAGCCC +GAGGCAAAAGCCGTACGGGACGCGTTGTTGTCGCAGAGATATAAGGGAAG +AACCGACGCCTATATCACACTACACACTTATTCACAGGTACTGTTAAGCA +GTTGAAAACTTTTTCTCGGCCACCGATATTTTCTCGGCCATCGATATTTT +CTCGGCCATCGTTATTTTCTCGGCCACCGAAATTTTTCGCGGTCATCGAT +ATACTCTCGTTCACGGATATTTTTCCCAGCAACAGATTTTTTTCTCGGTC +ACCGATATTCTCTCGGCCACCAAAATTTTGTTTTTCGTGGCCATCTATAT +TTTCATCGGCCATCTATATTTTCTAGGCCACCAATTTTTTCTCGGTCTCC +GATACTTTCTCGGCTACCAACTTTTTCTCGGCCACCAACTTTTTCTCGGC +CACAGATTTTTTTCTCGGCCATTAATTTTTGACGGCCACCGAAATTTTTT +CGGTCACCGATATTTTTCACGGCCATCGATATTTTTTGAAAATTTGATTT +GAGCAAAATATTTTCAGATTTGGATTCATCCATATGGTCACAAGAAGGAT +GCATATCCAGGAGATATTAAGGATTTGGTGAGTGATGACGTCATTCTTCT +TGAAACGTTGAAACTCAAATTTCCAGTACGAAGTTGGCAAAAAAGCTGCT +CAGGCTCTGAAACGGGTTTACGGCACAAAATACGTAGTCGGAAGCGGTGC +GGACACGCTCTACCCGGCGTCTGGAGGATCTGAAGATTGGGCAAAGCACG +AGGCGAAGGTCAAATTTGTGTACCTTCTAGAATTGAGGCCCGACGAGAAA +AGTAAAAAAAAAACGTTCAAAGTTGCTGAAAAAAGTTGGGCGATAATTTC +AGACTGGGATGGGTTCATACTGGACGAGAAGGAGCTGATCCCGACGGCTC +GGGAAACTTGGGAAGGTGTCCGAGTTGTGGCGGAAGCTGTGCTCGATCGG +ATAGTTGCCGGCAAGTCGACGGCTCCAAGAGGTAGGCAAACTTTGATGTG +CCTGCCTGCCTTGTGCCTACAGTTTTATTACGAGTAGGCACGGAGGTAGG +CAAGTAGGCAGGCAGAAATGTGGACCGATAGGCGTAAGGTTAAGGGCTTG +CGAAGCTTTTGCGTAGGATTGCGAAGAAAAAGAAAAATTTTTAAATTACA +GTGCGCACGGCCTAAAGGAGATGGCTTCTGAGGTAGTCACTACGATGCTC +CGCTTGCTCTGACCACGCCCCTTTCCTGGTTTCTCGATTTTTGTTTTAGA +AATTACACTTGTTTATTTTATGATTGTTGATAAATGTTTTTTTAAACATA +ATTTTTCTTGAAAAAACAACTTACAATTAGAGAAAATAGCAGCGAGCGGT +CGTGGCCGCGAAATGAAAAACTCGGCCACCAGCTATAAAATTAAAACGTA +TAATAATTTGGTGGTTCAGTTTTGCAGAAAAAAAATGGCTGGCCGAGTTT +TCACGTTTCTAGGCCATCTAGCAAAGTTGCTCTGAAGCGCTTTCGCGAAT +TCGTTTCCGAAAAAACTGTAGGTGAAAACTCGACCACGCTTTCTTAAAGC +CACGAAATTTTGAAATAATTTCTCGGTCACCAATTTTTTCTCGGCCACCG +ATATTTTCTCGGCCACCGATATTTTCTCGGCCATCAAAATTTTTCTAGGC +CACCAACTTTTTCTCGGCCATCTATATTTTCCCGGCCTCCGACATTTTTT +CTCGGCCACCGATATTTTTCGCAGCCGTCTATATTTTCTTGGCTACCAAT +TTTTTCTCGGTCTCCGATACTTTCTCGGCTACCAACTTTTTCTCGGTCAT +AGATATTTTTCGCAGTCATCTATATTTTCTCGGTCAGCGATATTTTCTTG +ACAACCCATGTTTTTCTCGGCCACCGATATTTTTCTCGACCATCTATATT +TTCTCGGCCACCAAAATTCATTCTCGGCCACTTATATTTTTCTCGGCCAC +CAATATTTTTCTCGGCCACCTATATTTTCTCGGCCACAGATTTTTTTCTC +GGCCATTAATTTTTGACGGCCACCGACATTTTTTTCGGTCACCGATTTTT +TCTCCGCCATCTATATTATCTCGGTCACCAATTTTTTTCGGTCATTGATA +TTTTCTCGGCCACCAATATTCTTCTCAGCCATCAATATTTTATCGTCCAC +CGATATTTTATCGGCCACCGAAATTTTTCGCGGTCATCGATATACTCTCG +TTCACGGATATTTTTCCCAGCAACAGATTTTTTTCTCGGTCACCGATATT +CTCTCGGCCACCAAAATTTTTCTCGGCCACCGATTTTTTTTCCTGGCCAC +AGATATTTTTCTCGGCCTCCGATATTTTTCTCGGCCACCGATATTTTTTC +TCGGCCACCAATTTTTTTCTCGGCCTCCGAAGTTTTTCGTGGCCATCTAT +ATTTTCATCGGCCATCTATATTTTCTAGGCCACCAATTTTTTCTCGGTCT +CCGATACTTTCTCGGCTACCAACTTTTTCTCGGCCACCAACTTTTTCTCG +GCCACAGATTTTTTTCTCGGCCATTAATTTTTGACGGCCACCGAAATTTT +TTCGGTCACCGATATTTTTCACGGCCATTGATATTTTTTTCGGTCACCGA +TACTTTCTCGGCCACAAATATTTTCTCGGCCACCGAAATTTTTCGCGGTC +ATCTATATTTTCTCGGCCTCAGCCATCGATATTTTTCTGGACCGTCTAGT +TTTTTTTTGGCGGCCGTGACCTCCAAATAGAATTACAAAAATAAACGATA +CATCTCATATTTCTGTGCAAATCCTCAAGTACCCCCCCCCCCCCCCCTAT +ATTTATTGTTCCAGAAGCCCCAAAAGCTCGCGGATTCCGATTCGGCGACG +GCACCGAAGGATCATGTTTCGATGTCCGACACGCGTGCAAACGATGGGTT +CAGGAACGGGAGGAGCTGTGCAGGACGGTGCCAATTTTCATGCGCGAGAA +CTGTGCCTACTCTTGCAATTTCTGTTGATTTTTTTGGTGTGCCACTTCTT +TTTTTCTGTACATATATCCATTTTGTCTTCTACATACATATATATATGTA +TATGAAATGTTTAAAAACCTAAAACCTAAAAAAAAACCAACCTAATACAG +TGTTCACGAGCGCCCCCCGCCGCCGGCGGCTCCTTATTTGCCTTGTGCTC +ACCGTGAGGTGGCTCCGCGCGGGAGCCCCAGTGATGAGCATCTCTTTTGT +CCACACGAATAATACAATAACACGGGCTCCTCTTCAAATATGACAAAATG +TCAAATTTTGGCGTCTCTCCTGACTTGGAGCTTCTGGGTCTTCAGACACG +TTCTTGTGTGTGAGGCGAGATGCGATTACCCTCTATATTATTGATTTTTG +GAGCATTTTTTGGTTTTCTAGGGGCTATTCATAATACAGATGATAATGCC +GGCTATCATAAGTAAGTCCCCAAAATACCCATATGGCCTAGAAATTCGGA +AAACTCTTCCATTTCACTTTTGGTAGGGACATTTGGTTTCTGTGCTAGCT +TTTATGCTGAACATGGTAATTTAAATTTCCTAGGCCAGTGTATATGTTTT +TCTAGGCTACGACATACAATTTTTTAGGCCACAAAATATTTTTTTTTAAT +TGCGGCTTATAAAAATGTTCCATAAATTATCTATTTTTGAATTACAGTCT +GAAAATTTCCATTTTTCAAGGGCACCTTTCTAGGTCACAAAAACGGATTT +TTTCAACATAGGCATTTTTCAACTTTTTCTAGGCCACGACAGATGGAAGA +GCTTTTCGTAAAAAAAGCTCGGCCACCACCCCACCTAACCAAAAAACTTC +CAGCTTCAAACTAATCCGAATCAATCCGGAAACTGAAGGAAGTGTGAAAT +ATCTTCGAAGTCTGTACGAGGATCCCTCTCCGTACGAGCTGGATTTCTGG +CAGCCTCCTACGAATATCGGTTAGTGTGACTTACCCACGTGATGTTAGCG +TGCTCCATTTTAGTTTGATCTACGTAGATCTACCAAAAATGCGGGAGAAG +AGACGCAAAGTTCTCAACTGATTCTGCATGGTTAAGAACGCACTGACGTC +ACATTTTTTGGGAAAAAAATTTCCGCATTTTTTGTAGATCAAACCGTGAT +GGGACAGTTTGCCACCACGTGCTTACCCAGGAAAATCTGAAATTTTTCGA +ATTTTCAGGAGCTATCGTAGACTTGACAGTTGCTCCGGCGGATGCTCCAA +GATTTGTGAAGGATTTGGAATCGAAGAAGATCAGCTACATCGTGGCGGTT +AATGATTTGTCAAAGTTCGTTTTTTTTTCTAGGCCACGGCCATCTGTGAC +GTCACTAAACTAGTTTCCAGAGCAATCGAAAACGAGCGCGGAAGCGACAA +ATTCTACAACCCGGTCGCTGGTTTTGCATACGACAAGTACAACAGTTTGG +AGGAGATTCAAACAGAAATGAAGCGGCTTAAGAAGGAATACCCGACCATG +ATCACGCTTATCGATATCGGACAAAGTCACGAGAATCGTACGCTTTTGGT +GATGAAGGTAAGAGCGAACGCGCTCTATTGAGTGGGCGTGGTCACGTCCA +CGTTTTGCAAAGTGGGCGCACGGTTCCTTTACAGCGGTCCCAGCTTTTGA +AGTTTTGAGTAATTTTTATATGGGAATTGCTAAAATTCATTTAAAAAAAA +CCCAAAAATACTTTTAAAGTCGTAACGAAAAAAAACAACCGTGCGCACGT +CTTGCAAAAAGTGGGCGTCCCAAAATTTAAAAACGACGGAATTTCATTAT +TTCAAACGCTCCAAACTCATTTTCACTACAAAGACATCACGCGCCTCCTG +GGAAAGCCCTTACTCATTTGCTGGATATATGACGTCACTAAATTAGTAGA +TGTGTGAAACCGCGCTCCATTGTACTACGCAACACCGATCCCACGTGGTG +TCAAAGTGTCCCATTTCGGTGTGATCTACCATAAATGCGGAAATATTGAC +GCGGATTTCTAAACAGATTTCGCATGGTTAAGAGCGTGCTGACGTCACAA +ACTTTTCTCTGCAAGAAATTCCCACATTTTTTGTAGATCACACTAAAATG +GGACCGTTTGACGCCACCTGCGCTCTCACTTTCAACACTCCCATTAAGCA +TTTCATGTACGCGCCAAAACGCACGGATTTCTGGCTCCCCTCATAAATTG +AAATGGAGTTTGAAAAAGAGTTTGCCGAACTAGGTCATTTTGGCTCGGCC +ATATTTGGGGTAGATTTTCGCCGCGTTGCGTGTCGCGTCGCGGCTCAATT +TAAGTTGTAAATCTAAATGTGTTTGTCCGTGTGGAGTACCCGACTTTTCC +ACGCGTTGCCCGGAATGCTATTGTCGATGGAGCGCGAAAAATTCAATAAG +GAAGGCCAGAACCCCGTGAAAACGCCTGCCGCGCCCCCGCCTGCCTTGCA +GCGCGGAACCCAAAAAGTGTCGGCCGCGGCGAAAGGCCCTCGCACTATGT +GGTGTTAATACCTAGCTATTGACTTATCGCCATAGTGTAAAAAAACCCAA +ACTCCCAAATTTTCAGATAACCGGAAAACGAAACCCCCTCGGCTCGAAAA +TCTCCATGTGGATTGACGCTGGAATTCATGCTCGAGAATGGATTGCTCCG +GCGACCGCAATGTACATTGCTCATGAGCTTCTCCTCGGGTATGAAAACGA +CGCGACGGTGGCTAAGCTGATGGACCATATCGATTTTTATATTCTACCTG +TGATGAATCCAGATGGATATGAGTATTCCAGAGAAAAGGTTGGTTTTTGA +ACCTTAAAAAAGCCTTAAAACTAGTGCTCTATTTCAGAACCGCATGTGGA +GGAAAAACCGGAGCCCCGCAAAATGCGCCCGGCAAACTTTCAGTACGGTC +TGCTGCTCTGGAGTCGACCTCAACAGGAACTTCGATTGGTTCTGGGCCTG +TAAGTCACGTGGTGTGAGAAAGTCTCATTGAAGTTTGATCTACAAAAAAT +GCGGGAATTTTTTGTAGATCAAAGCGAACTGGGACTTTCTGACTCTACGT +AGTTAGCTCAATATTAGACCTTAAAAAATAACTTAATCTTAAAAATTTCC +AGCCACCGGTTCGTCTTCGGATCCGTGCCACGACACGTATCACGGCTCGG +CGGCCTTCTCGGAGCCTGAATCACAAGCTGTCAGGGATTTCCTGGAGCAA +AACACACCCGAGGCGTTCATCTCGCTGCATTCCTACTCCCAAATGTGGTT +GATACCATATGGACACAGAAAACAGAGTTATCCACAGGACTACCATACTG +GACTGCGGCCATTGGCTCTGCGAGCAACTAAGGCGTTGTATGAGTTGTAT +GGGACGAAATATCAAGTCGGGACCGGCGCTGATTTGATGTGTAAGTTAAT +ATCCTTTTTTTCGAATTTTTAAATTTCTAAGGATTTCAAGAAATTTTAAA +ATTTTGAAAATTAAAAAAACAATTTTTTTCGGAATGTTTAAAAATTAAAA +AAAAAATTTTTTTAATAGATTTTTTAAAGCTTTTTTTTGGAAAATTTTGG +ATTTCTGAATAATTTTTTTTTCAGAACTGGAATTTTTGAGTTTATTAAAG +ATTTTTTTAGGACTTTTTAATTTAGACATTTCCTGAAAAATTTTTAAATT +ATTAAAATTTCGAACTTTTTCGATATTTTCGGATTTTTTTGCAACCTGAA +TTTTATTTTTTTTTTGGATTTATTGGAATCAGGGGTGGGCAGCAAGATTT +TTTCCGGCAAATCGGCAAATCGGCAATTTGCCGGAATTGAAAATTTCCGC +CAAATCGACAATTGCCGGAATTGAAAATTTCTGGCAAAACGGCAAATCGG +CAAACTGCCGGAATTGAAAATTTCTGGCAAACCGGCAAACAGGCTAATTG +CCGATTTGCCGAATTTATCGATAAATCAGTTTGCCAAACGGCAATTTCCC +CCACCCCTGATTGGGATCTTTGAAATAAAACAGGAAGAAATTTTAAATTG +TTGGAAATTTTGTAATTTTCCGGAATTTTAATAAAAAAATGCTGAAAATT +CTAAAAGTTTTGGAACTATGTAAAATTATTTGTGATTTAAAAAAAAACAT +TTTTTGGACTTTTCTGAAATTTCACGGATTTCTGGCTTCTCTCATAAATT +GAAATGGAAGAGTTTTTGCCGAACTTGGCCATTTTGGCTCTGCCATATCT +GGGATGGATTTACGGCGCGCTTCATGTCGCGTCGCGGCTCGTAAAACTAA +ATGCACTTGTCCGTGTGGAGTGAGGAGAAAATTCAATGAGGAAGGCCAGA +ACCCCGGATTTTTGAAATTTTGAAGTTCTGAGAAACCTGTGACTTCTACA +CTAACCCTGAAGAATTTCAGACGAAGCTTCTGGAGGATCACATGATTGGG +CTAAGGGGCAGCTTAAGGTCCCCTATGCCTACCTGATTGAGCTCCGACCA +AAGAACACCATGATGGGGTAAGCAGGACGATGGATCCTATCAAAATTAAA +ATTTCATTCCAGCCACGGCTTCCTTCTCCCCGAACGAGAAATTGTGCCCA +CTGGACTGGAAACCTTCGAATCCATCAAAGTGGTTGCCGACGAGCTTGTG +GCGCAATTTGTGGAACCTGTGATTCGAGCCAAGCTGACCACAACCACAAA +GCCCGCAATCCCACCGTATCGGCGTGGGTACTCTATAATCGACACCACAA +CTATGGAGCCGGTCGATGAGATTACACAGAAGCCTACAGAAGCTCCAACC +ACAGAGGAGCCCACCACCACTACTACGGAGGAACCTACAACTACCACAAC +GACCGAGGAGCCTACCGAAGCCCCAACAGAACCCAGTCCGACTACTGTCG +AGGCCACCGAGGCTTCTACAACACCAGAAGCTTCCACATCCTCTGAGACA +AGTACCACAGAGAATTCTGAACCCAACCAGAAGACATCCACACCAGTGGC +ACCTGAAGCAAGCACCGTTGAGGAGGTTGGTTTTTGGCTTAGTCTCAGGC +TTAGGCCTAGGCTTAGGCTTAAACTTAGCCTTAGTCTTAGACTGAGGTTT +AGGCTTAAGCTTAGGCTTCAGCTTAGGCTTAAACTTAGTTTTATCTTAGG +CTGTGGCTTAGTCTTAGACTTAGTTTTAGGCTTAAGCTTAGGCTCAGACT +TCGGCTTAGGCTTAGGCTTAGAATTAGGCTTAGTTTTAGGCTTAGACTTA +GTCTTGGGCTTAAGCTTCGGCTTAGGCTTAGTCTTAAGCTTAGGCTTAGG +CTTGCACTTGGGCTTGGCGTCAGTGGCGAGCGTGAGCTATTTAGGGTTTT +ATGCTTAGCTTTAGACTTAGGCTGAGGTTTAGGCTTAGGCTTCGGCTTAA +GCTTAGGCTTATGCTTAAGCTTAGGCTTGGACTTAGGCTCATACTTAGGC +TTAGGCTTAGGCTTGCACTTGGGCTTAGGCTTAGGCTTATGCTTAGTTTT +AGGCTTAGATTTAGGTTCAGGCTTAGGCTTATACCTAAGCAAATACATTT +TTGGAACTATTTGGATATTTGCCAGCGACCTATTTTATCAACTTCGAATT +TCCCAAACCATTCCAGGAAACAATCACACCGATCAAATGCGTCGACTACG +GTGACTACTGTCGTCTTTGGGGAGTCTTACAGCTCTGCTATCGGGATCAG +GTCTCCAAGTTGTGCCCCAAGACTTGCGACTCGAGGTGCTCTTTTTCGGT +GTGAGGCGCACGCTGGAAACTATCGTATGACAAATTGTCAGCTTATGTAT +GTATAAATGATTTCAAACTTTTGTAATTGTGGACTAAAAACTACATTTTT +CATGCCTGACTGACTGCCTGGCAGCGTGTCAGCGCCCGACATTTTCTGAG +TTCCACGACGGGATCCTGGCAGGCGTAGGCGTGCAATTTTTAACTCATCA +AATTGCTTGGAATAATTAAGCACTGCTACAAATGATGTCACTAGCTACAA +ACTACAAACTAGGAATTTCACACTACAAACTACAAACTACAATCTTAGCT +CTTCAAGCTATGAAATACAAACTAAGAAATTTTTATTTTTCAATATTTTT +TAAACGAGGTGTAATTATGGGCGTATATAGTAAAAACTGGAACGACAAAA +TGCAAATCACAAACTACAAACTAGAAACTAAAAACTAGAAACTGCAAACC +ACAAACTACAAACCACAAACTACAAACTACAAACTACAAACTACAAATTA +CAAACTACAAGCTACAAACTACTGAACTCTGAATAAATTTGAACGTGTAA +ATTTTGCGTTTTTGTGCAATGATTGGACGTATGAATTGCGAAACCATAAG +TGTTTAATCACATACTACAAACTACAAACTACAAACTACAAACTACAACC +TAGAAACTACAAACTACAAACTACAAAATATAAATTACAACCTTCAAGAA +ATTTGTATTTTTCAATATTTGTCGAACAAGTTTTAATTATTCGACGAATA +AAGTCAAAGCTGAAATCATAAAATGCTAACCACAAACTACAAACTACAAA +CTACAAACGGCAAACTACAAGCTACAAATTACTGAACTCTAATAAAATTT +GAAAGTGTACTCATGGTTTTGTGCAATTACTGGACGTATGAATTACGAAA +CCATAAGTTTTTAGTCACACACTACAAACTATAAATTACAAACTACAAAC +TACAAATGAAAACTACAAACTACAAACTGGAAACTACAACAGCAAACTAC +AAACTACAAACTACAAGCTACAAACGCTTATATAATTCGATTTTAGTTAT +TTTCTGTTTTTTATTTTTCCAAATTCTCAAACCTGAAATAAAATTACCTA +CACACAAATGTTTCTCATTATGCATCGAATGACTAATATTTTCCAATAAA +CGTTTTGAAAAAGTATGGAAGAAACAAAAAATGGAAAACAAAGGCGGAAA +TATGCATTTTTCTTCTCATTTTCTTGAAATTCGTGTGATTGTACTTATTG +ATTTTTTGTTGTTGTTAAAAACGTGGTAGGCAGGCATTCATGCCTACGTG +CCTGCCTACCAGTCGAATTCGAACCCGCAAGATGTCGGCCGCTCCCTTCG +ATTTTGGAAGTTTTTACTTATTTTCCTCTTCTGCTAACACATTAGACAAT +TATTATTCAACCCGTGTACACAATAGGGCGGCTAATAATTAGGTTGGCAG +GTAGAGGTGTACAGGAAACGTTTATAAGCTCTTTATTTACTACTGAGCTA +CCACTTATTTGGAGCCAATGCATTTTGTTTCTCAACAAGTTGGAGATTCC +AGAACAACCAAGATTTGGGCGGGGCTTATTTTGAGGCAATTTTTCAACTG +TACAGTAGATTCATATAATTTAAGTTTTGAAAACATTTAGGCGGGAATTC +AAACATTTATTTTTAAAACCATCTTGGCGGGAATTCAAATTCTAGTTTTT +CGAAAACACTTTGGCGGGAATTCAAAATGTTATTTCTTAACAACTTCCTG +AAATGCTCTAGAACCTTCTGGAATATTTGAGAAAACTCTAGAATGTTCTA +GAACCTTCTGAAAAATTCGAAAAAAGTCTAGAATGTTCTAGAGCCTTTTG +GAAAATTCGAAAAAAATCTGGAATATTCTAGAACCTTTTGGAAATTTTGA +GAAAATTCTGGAATGTTTTGGAACCTTCTGGAAAATTCGAGAAAATTCTG +GAATGTTCTAGAACCTTCTGAAAAATTTGAGAAAATTCTGGAATGTTCTA +GACCCTTCTGGAAATCCGAGAAAATTCTGGAATGTTCTGGAACCTTCTGG +GAAATTTTTAGAAAAATCCTGGAATTCTCTAGGACCTTCTGGAAAATTTG +AGAAAATTCTTGTCGCCAAAGTTTTGTGAAAAAATTTAGCTGGAAACTAA +ATAATTTTGTGAGAATTCAAACTTTAATTTTTCCAATTTTTTCGGATTTT +TTTTTTAGCTTTTAAGCTTTTTACATTTTCTATAAATTTTAGATTTCAAA +AAAAAATTGGCGAAAAATTTTGACCAAATTTTTTGGCTTTATAGCATAAT +TTCAAAAAGTTTAAAAAGTCCAAACTTTGCTCCAGTCCCCAAAAAAAAAT +TTGGTGGAAAATTCAAATCATGTTTTTTTTTCAAAAAATTTCATGGCCTA +GAAATTTCAGCAAAGCAGTAAGGCCGCCTACCTCCCTTCAATCCGAAAAA +TACCTAAAAATCAATCCCAAGCAATTAGTCTCATCAAGAAAGAAAAGAGC +TCTGCTTGTGCCCACTCCTCATCTCTTCTCATGTATTTGCTTTCAATTAA +ACATCTTACTCAGACAGCATAACGAAGGAAACAAAAAACGAAAGAATAAC +GAAATGAGCATATTTCCTTTATTTATTCCTTATTTATGTATTCAGGTAGA +ACAAAAAACCGGCTCGGCGGGTTTATTTGTCTGTAAATCTTATGCCTACA +CGCCTACCTACAGCGGCCCTGACTGCCTATTTGCCTAGTGTTTTTTGTCC +TTTTCGGTTGGTTTTTTTGAAAATTTTTCCTGATTTTTTTTGTCGTTTTT +TTTCCATTTTTCTGAATTTTTAGGAATTTATGGAAGTTTCTCTTTTTTCT +CCCCCCCTCGAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCC +TAAGCCTAAGCCTAAGCCTAAGCTTAAGCCTAAGCCTAAGCCTAAGCCTA +AGCCTAGGCCTAAGCCTAAGTCTAAGCCTAAGCCTGAGCTTAAGCTTAAG +CCAAAGCCTAAGCCTAAGCCTACTCCTATGCCTGAGCCTAAGCCTAAGCT +TAAGCCTAGGCCTAGGCTAAAATAAGCTCGGCCCCTTTCTGGGCCAAAAT +TTCATGTACCTCCTAAAATTGTTTCATCCTAAATAGCCAAAAAACTTGGA +AAAATCTATTTTTCAAATTTTGTAAAAATGTCAAAGAAAAATTCTCAGAA +GTGCGGGAAAGTTTGACCCAGAAAGGGGCGGAGCCTATTTTTGGATAGGC +TCCACCTCTTTCTAGGTTTTTTAAAATCAAATTTAGGTGTTTCCTGGTAA +GTTTTAGTGGTTTCATTTTTTGTATTCATCACATTTCTTTTTCATTTTTT +ACATTTTTCTCATAATTAATTTTTGATCTACCTGTTGAACTTGACCCCGC +CCCCCAATCTTGGTGCCTCAAAGGAATCGGAGGAGTCTAGTCAACAAGGT +AGATCAAAAATAGAATATGAGAAAAATTTGCCATCGTGTTTTTCGATAAT +ACTACAGTTTCATACAATAATCCCACAACTTAAAATTCAGCAAATAACCA +GGAAATGGGCGTGGCTTAGATTTTCAAGGTTTCGTTGTTTTTTCCAGGTT +GTACTTCTGATCTGAACGGGCTCCGACAAAAAATGCACAAAATTCGTAGT +AGTGATGTGTGACGTCTGTTCTGATGACTCGAATTCATATTATAAAAGTC +GAAAAATTCCTTCCGAACGAACCCCCCATCATCCTAACATCATCCAGATT +TCTGCACCCGCCCGCTCATATAATCTGCTTTTCTTCACCCATAATCTTTT +TGCTTATTTCTCAATCTCCGTCTTTCTTGCGTTTTTAATTAATTCAAGAA +ATCAAGCAGTTGTGGTTAATGGCGTTCTACGAATTGCTTTTTTCTTGTAT +TATGATATTTTAATTAATTTTATTTATTTAGTATCTAGGCATGTACATGT +GCAAGTTGAGTTGAATAACCTGAAAATTTTGTGCCAAGTTATGGGCGGGG +TCTTTCATACATTTTTTAAATTGTTTTTTGGCTAAATTTGTATGTATTTG +CTTTGAAAGTTGTGTTTTTTTTCAATTTTCTTTAAAAAAAAACCAAAAAA +AAAAATTGGTATGTAGTAACGTAGGTAGGCAAGAAGTAGGTGTGTAGGTA +GGGACTTGAAAATAGCAGCTATGAATAGGTGCGGTATTTGAAGTTTAGGC +AGGTTCGTAGGCAGATAGGTGAGTAGAAAAATCATTCAGAAGACATTCAG +GTAGGCTCACTGGTAAACAGGCATAATGTAGGTACGTAGGTTAACACTTA +CGTACGAGGCAGTAGGCATCAGGGCTTTGTGGCAACCGGCAACCGGCAAC +CAAAAACCAGGTTGCCGGTTACCGAAAAATTGCCGAAATTTCAGCAACCA +AAAGTCGCCAGAATTTTCTCGAATTTTCCAAAAGGTTCTAGAACATTCCA +GAATTTTCTCGAATTTTCCAAAAAGTTCTAGAACATTCCAAACTTTTCTC +AAAGTTTCCAAAAGACTCTAGAACATTCCAGAATATTCTCGAATTTTTCA +GAAGGTTCTAGAACATTCCTGAATTTTCTCGAATTTTCCAAAAGGTTCTA +GAACATTTCAGAATTTTCTCAAATTTTCCAAAAGGTTCTAGAACATTCCA +GAATTTTCTCGAATTTCCCAAAAGATTCTAGAACATTCCAGAATATTCTC +GAATTTTTCAGAAGGCTCTAGAACATTCCAGAATTTTCTCGAATTTTCCA +AAAAGTTCTAGAACAAGTTGCAGAAATTTTCAGCGTACGGCAACTTCAGC +AATTGCGGGTTGGCATGTAGGCAGGCAGGCATGTTAGTAGGCAGTTTTGA +CAGTTTTGAAGTTAACAATCCTACCTGATGCACAAGAAAATGCGCGGCAA +TTGCGGACCGGCAATTCTACAAAATGAGACGGTTGGGCATGTTCTTCCGA +TATTTTTTATAAAAATTTAATGATAAAGTATAGAAAAATATTTGTTTTAT +TTGAAAATAAGTTTTATTTGGCTAGGAACAACCGAAAAAGTGCTCAAAAA +TTGTCGGAATCTTGAAAATTGCCGTGAAAATTTCCAACATTTCGACTATT +TCTGGAGATTTTTACAATTTTGTCTATTAAAAAAAAACAGTTACTTTCAA +ATAAAGCAAATATTTTTCTATATTGTGTCATAAAATTTTAATGAAAAATA +TCGGGGGAACATGCCCAACCGTCTCATTTTGTAGAATTGCCGCGCACCTT +GTTAGTTTATCCCCGTAAACCTCCAATCAATAATTGGCAGGAGTCCTTCC +GTCCGTCCAAAACGTCATAAAAACTGGAGATGGCAAAATTGGAGATGTGC +CAAGTTTGCTGGAGAGGTGGGGGGAAGGAGACAATCATGTTGTCTGCGTA +TCTCCAGACTCGTCTGCTATCTCTCTTACCCGGCAAATGGGACCTCCCCA +GAACGGTGATTTTGTCCTTTCAACACCTTTTTTGTGTTTTTGTTTGTTTG +ACACCTTTTTTTCACTACTTTGCGGGAATTTAGACTGATTTCTCATGGTT +AGAAACGTGCTGACGTCACATTTTTCGCGGGAAAAAAAACCCGCATTTTT +TGTAGATCAAACCGTAATGGGATAGCCATTCTAACAATTCACTGTTTTTT +TTCTGAACAAGTCTGAAGTTTTGAGTTCAGCACCCGCAATTCTGTCTCTG +ATAAGTTTGAAAGTTTCAAATTGAAACCTCTCAATTGTCGGACCAGCGCG +CTACTTCATCATACCCCGCAAATTGAACTGCTCGCGGCAAAATTTAAAAA +TTGATGCTTCTCCAGAAACATCCCACCAGAAACTACCTAAGACTGAACTT +CATTAACTTCTTTTAAACTTAAACAACGATCATAATACCTTAAAAAAAAC +GTTTGTACGTGGTGTCAGAGTGTCTCATTTCATTTTGATCTACATAGATC +TACAAAAAATGCGGGAGAAGAGACGCAGAGTTTTCAACTAATTTCGCATG +GTTAAGAACGTGCTGACGTCACATTTTTTAAGACAAAAAATTCCCGCATT +TTTTGTAGATCAAACCAGCCTGGCACCACGTGCGTTTGTAATCGTTCAGT +AGGTAGGTAGACACAGGTCAGTAGGCATAGGCAGGCGGTAGGTCTGAGGT +AGGTGTTGTTGACCACCACGTAGCAAAACATGCTTGACGACTAGCCTCAA +ACGGATAATCACAAAGTTCTACGTAGTTATGATTTCAAGCCGCCCAATGA +GCACATTACGCTGACTAAGCCACAGCTATAAGACCCTCCTCCGAGTATAT +TCATCACCAAACATCCAGTTTCCAGTTTTGCAGTCTTTTTTTCTGTTGGA +AAATAAAGAGAGTACATCTCATTAGACATTAATGAACAATTTCAAGTTCA +AAACTATAAATATAAATAAAGCTAGTAATTGAGCCAGTCCAACCAAATTT +CCCACAAGTTCATTATAAACCTTCCAATTTCCCAATCCCATGTACTCCTA +CTAATCAGTTTCTTTCCTTCCGCCCTACTTTCCAAATTCATTTATCCGCT +TTGCATACTTTTCGGTAATCTTGACGATTTTCAGAGGTTTCTAGAATTTT +TTATTTTTTCAAATTATGCAAAAATAAATTTTTTTTTGTATTCTCAAAAA +ATTGCTAAAATTGTCCAACTTCCCATTTCTCGGAAATTGACGTAATTGCA +GTTTTTTGAATTTTTTTGAAATTACTGATTATCAAATTTTGTTGGAAAGT +TTCCTTTCACCTACACACCTACCATATGCCTATCTGCCTAGGTGCTTACC +TACACGCCTGCTTCGTGCCTACCCGCCTACCTGCCTGGTTTATTTTCAAA +AAGTGCAAAGAGCCAAAAGTTTCGAATTGTCAAAATTGCTCGGAAATTTT +TTGAAATTTTGGAAAATGCCAAAGTTATCAAATTCCGCATAATTCCAAAA +TTGGCAGCCCGACATCATGCCTGCCTACATTCCTGTCTGCATATAGGCCT +GACAAAATGTCCATCAATGTATGTACCTATTTCATACCTATCTACCTGTA +TAAACATAGTTCATCTCTACCTCAAACAGCATGTTACAGGCTTTCTTCTT +ACCTACCTACTTCATTAACTGCTGTTTATTGACCTGTCTACGTGCCTACC +TCATGCCTGGCATGCCTACATACCTACCTCATTTATCAGATCCTCATGAA +GCCTATTTACAAGCCTACTTCCAGCCTACCTATTGTGTTGATTACGATCA +CCGTCTCTAGGTTGCCTAACCTGCCTAATTGTGTCTACCTACTTAGCTAT +CTCATGCCTGCCTACTAACCTGCTCAAGTACCTACTTCATGCCTACCGGC +CTACGTTCCTACCAACGTGCCTACCTGCCTGCTCACTAGCCTAAGTGTCT +GCCTACATAAATTGTCCGTTAGCACATCAAACTTTTCATATATACAAAAA +ATTGCATAAAAAGAAGATAATCATTAATAACAAGTGGGTAACTCAAAAAG +GAAATTGGTTTATCTCCCGGCTCCGAGAGCACCAGCACTTTGCTTTTCCG +TCACTACAACCTCTAATTTTGTTTTGTTCGAAGGACTTTTTCCGATACAT +ACTAATTTTTTCGGATCCGGTTGGCTCTGGATTTCAAGTTTTATAATAAC +TTGGGCTCCCAGTGACGTCACCAAAGGTGCAATTAGCCTTTAGTAACTAA +ACAGCTTGCTCCTAGTTTACTGCTCCGTCTTCTCAAATGAAACAGAGAGA +GAGAGACCCCTCATCGAAAATTCAATTAAACGCTAAAACGTAGGTAGGAA +AGAGAGAGAGAGGGAGACTCCTCCCAAAAAAAAAAGACAGGGGGGCTCTC +TCTCTCTCTCTCTCTCTTCGAGCGGCAAATCGGCTTCCGAATTCATTCAA +AAACAAATTATGTGCTCAACCACCACCACTACCACCGGCTCCAGGCGGGT +AATTACACTTGAAAACCAAGTACTAGGTTTCGTGGCCGGGCAAACTTTTT +CTTATTAGACCCCGGTGGAATTTTGTAGGTCTATTTAAAATTGCAATTGC +GCTATTTTGTACTGTTTTTTTTTTGACAAACTTTGAAGCTTGATGTCAAG +CTGGAAAAGCGCTCTAATGACAATTTTGACTGCAAACTCGCTCTGTTGAT +AAATGGTCCGTGTACTCCACGGGGGCAATTAAACTGGATTTTTTTCGATT +AAATAATATCTTGATTTTTTGCAGTTTTGGCTTAGGCTTAGGCGTAGGCT +TAGGTTTAGTCTCGGGCTTAGGCTTATGGTCAGGGTCAGGCTTAGGCATA +GGCTTGGGCTTAGGCTTCGGCTTAGACTTAGGCTTAGGCTTAGGCTTATG +CTTAGGCTTAGGCTTAGGCTTAGGCTTAGGCTTAGGCTTAGGCTTAGGCT +TAGCCTAAGGCTTAGGTTTAGGTTTAGACTTGGGTTTAAACAGGCTCAGG +CTTAGGCTTAGGCTTAGGCTCATGCTCAGGCTTAGGCTCAGACTTAGGCT +TAGACTTAGGCTTAGGTTTTGGCTTAGTCTTAGGTTTGGACTTAGTCTTA +GGCTTAGTCTCGGACTTAGGCTTAGGCTTAGGCTTAAGTTCAGGCTTAGG +TTTAGGCTTAGTCTGAATATTTGGCTTAGCCTTGGGCTTAGGTTTAGGGC +TTAGGCTTAGGATTAGGCTTTGGCTTGCCGGCCACCTGGGATATTGTGGT +TTGACAGGGGTAGGCTATCCAAATTTTAAAAAAATCGGCTACAAAATTAA +TATTTAGATGGGCCTATAAACCATTTCTCTAGGCCATCCTGCAAAATTTC +CAAGACAAAAAATTTCAGCCGTGAATAAAGTTTCCGTTTTCCTAGGCCAC +CTCCAAATTTTCCACGTCATATGTAAGGTATCGGAGGGTACTGTAGAAAA +TTATCAAAAATCAGCAAAGAATAATAAGCATTAAGAAAGTTTTTTGTGTG +TGTGTGTTTTTTGTGGGAGAAAACATTTCCCCTCTCCTTTTTTCCTGCCT +GCTCATTTGGATACCACCGCTAACCCAACTTGACTTTGATTACCCATTTC +CGTCCCCCTTCTTCGTCTTCTTCTACTCCGGGATAGAGAGAGAGCTCTAT +ATAATTACTTTCGTCTTCTTGATCCGTTACCGCCCATTGGCAATTGGTTT +GAGCTGCCGCCGGAGAATATATACATGCATGTCTAATTTTTTACTGGAAA +ATCTAGGAATTTTTACGTTGAAAATTTGGTTAAAAGCGTACAGATCGGCC +CATGCTGGTGATTGTACGAAATTTTAATTTCAAAGTATCTGCAGAGGAAG +CTAGGCCACAAGCCCCTACGTGGCCGTCAAAATTGAAAACTAGGCCACCG +ATTTTTTCTCGGACTTTTTATCTACTTTTGCTATTAGGCCCTGTCTTCTT +TTTTGCAACGTTTTTCTACTAGGTCACCAAATTTTTCCTAGGCCAAGCTG +CCTAAAACTCGGCCACCGATTTTTATTTGCGTCGGTCTGTAACATTCAGG +CTCCGACCAGCTCGACTTTTGCTACGTGGTCGCCAATTTTTCCTAAGCCA +CATCGAAAATGACTCGCTGTGACATTTGTACTTTTTTTCACACGGCCTAG +AAATTTTGAAAAAAACTCGGCCACTGATTTTATCGGCCTTGGAATCCTAT +GTAACTTTGTGGCATGATTTTTTATTTATTGTCCATCCAGTTTTTCGTCT +GAAAATTACAAAATGTTTTAGTGACCGTTGGAGAAAACTCGGCCACCAAT +TTTTTTCTCGGCCAAGTTACCAAATTACGGGATACCGTGTTCTCTATCAT +ATTTCTGGCTCAAAACATACTCTACTTCCGTGCTGCCTACGTGGCCGCTC +AATTAGAAAACTCGGCCATCATTTATTTTCTAGGCCATGTCGAAAATAGG +TAATGTAAATAGGCAAAGAAATGCGGTGGTTCAAGTAATTTTGGGAAATG +GATTTTAAAAAGTTGAAAAAATAAATCAAATGAATAAGTCTGAAACACGC +AAACCTTAAAGCTAGGCCATCAATTTTTTTCTCGGCCAGGTTGCCAATCT +ACGGGAAACCGTCATGTTTCTTGCTCAAAATTACACCCTATTCTCGAAAA +ATTTTTTTTACGTTGAGTATGCTCTCCTGCCTAGGTGGCCGCCCAATTAG +AAAACTCGGCCACCCATTTTTTCTAGGTCATGTCGAAAATAGGCGATGTA +ATGGGGTAGTTCAAGGAATTTTGCGTAATGAATAACCCCAAAAATGTTTT +CAATATATGGCCGCCAAAAAAGAGAAAACTCGGCCACCAATTTTTTCTCG +GCCAGGTAGGCTACCAATCTACGGGATACCGTGCGCTCCATCCTATCTCA +GGCTCAAAATTACGCCTTTTTTCTCGAAAAATTTTTGCATACTCTCCTCC +CGTGCGGTTCTTAATTAATGAAAGACGTTTTTTTTTCTCCTTGTCTAACG +AGTGTATATGCAGAATTCAGGATATGCGTCTTCTTTTCCGAGTTCTTGTC +TTCAAAGCGAAAAAAAAAGTGTGTGTGTGTGTGGACATAGGAAGACTCGT +CTTCGAAGAAGACGCTCATTAGCTCATTTCATCCACTCGCTAATTTCATT +AATTTTGTGCTTCTTCGCCTGCCTTCCGACGTGTTTACCCACACCACCAC +CACCACCACTCAGTACCTCCTCACTCACCGTGGAGAAAGATGTTCTGGAT +TTTTTTAAGCTTTTGAGTTTTGTGTCCTACCTCACTTTTTAGGCTCCACC +CACTTCTTGGCCTGTTATTTCGGTTTATTAGAATTTGTGTGGTGTACTAC +AAATTTCGATCCGAAAAATGGCAAAAAAAATTCAGCTGACTGAATTTTTT +TGAACTTTCAAAGGTTCAGTTTTTGCAACCTAAACCTCTCTTAACTTTAA +CTTTTCAAACCCCGCCCATATCTTGGCTTTTCCAGAAATCCGAGTAATTT +TTTGGGAAATTTATGGTACAACTAGCTATCAGAACAATTTTTACGGAAGT +TTTTTTAATTTTATTTTAATTTAAGTCTACTGAAATTGACCTAAAATATA +TTTTGAAAAATGCTTTGATCCCGAAATTGGCCAAAAAACGTTGATCGAAT +TTTTTTGAACTTTCAAAGGTTCCGTTTTTGCAACCTTTAAGCCCCGCCCA +TTTCTTGGCTGTATTGTATTCAAAGTTAAAAGTTGTTCATGTTGTACTAA +AATATGCAAGTATCATAAAAAATTAACTTTTTAAGCTCCACCCATTTCTT +GGTTTTTCTGGAAATCCGAGTAATTTTCTGGGACTGTTATGGTACAATTA +GGTATCAGAAAAAAAATCAAGGAAATTTTTTACTTGGATTTATGTCCACT +GAAATTGACCTGAAAATGTTTTGAGATTTTAAAAAACTTAAATATTTTGA +TAAAGGTAGAATTTGAATTCCCCGCCCATTTCTTGGCTGCAGTTCCCAAC +TGTCCAACTTTTTGAATATTTTCTCAAACTTCATGGCCTAAAATTCCAAT +TCTAGGCGATCTACCTTGATAAGAACTTACTCCTGAGTTATGTTTGAAAA +ACATAGTCCATCCGTGGCCTAGAAATCCAAAACTAGGCCATCAGATTTTA +GGTTCCTAGGCCCAATCACAAAGCCAGCAGTTTTAAGTTGTCAAATTTCA +GTGGCATAACCTCATAATTTAGACCTATTCTATTAGGTCAGCCTATTACA +GTTTCTGGCCTAGAAATTTTCCTTGAGTTTGAGCCCACTACCCCCACACC +CACATGGCCTAGAAACCCAAGCCTAGGCCATGTGTCCCCGCATTCTCACT +CACTTTTAATTTCTTAATCCACTTACACAATTCTCTCCCCCTTTTCCAAT +TTCACATCGAACCCGGGAAAGCTCATTAGCTCATTTGTTGTGTGTGTGTG +AGTTGAAGAAGCGGGGGGAAGGGGAGCCCCCCTTTTGAGTGGACGGGGAG +CTAGAATGGAAAAAGAGAGAAGGAGGAGAGCCATTTTGAATGGGTATGCA +ATTAGCAATCGATGCAAATTAATTAAACAAACAACGAAATGAAAGGGGGG +GGGAGGGCAATCGCCTGCCTTCACTCACATGTCCCCTGCTGGAAATGTGG +AAATGTAAATTAAAATTAGAAAACTAGCAAAAAAGTGCGTTTTTTATTCC +TACTTGTTAATTAGTTTAAATTTCTATATATGTATGGCTTTGACATGCCA +ATTTTGGCGTCTAAGGGTAGGTATAGGTGGGCGATGCACCATGTTAAATG +GTCGATGCATCATGCCAAATAGTAAATGCACCATTACACATTGAAAATTT +AGCATTATACACTCCATATAACTGAAATTCGGGGCCCAATCAATATCATG +CCGCCGACATCTCACGGACTCCGCGCGCCGCTATGTTTAACTCGCAGCGG +GCGGAGACAGCTGGCCGCGCCCACAACGAGTTAAACACAGCGGCGCGCGG +AACTCGTCAGATGTCGGCGGCCTGATATTGGTTGGGTCCCGAATTTCAGT +TTTATTATTTGGAGTGTATAATGCTAAATTTTCAGTGCACCGTGTTAAAT +GGTCGATGCACCATGATAATGCTAAATAGTCCATGCACCTTGTCTAGAAA +ACTCGTTGAGTACTGTACTTATGAAACAGTTTAGCAAAAAAAAATGTCAG +CCTGTTTGGCTCCGCCCCGAAAGTGGGCGGAGTCTAATTTCTTGAATTTT +TTTTTTTCAAAAATTGTTTTAAAAATAGCTCTGTGAATTCCACCTCAAGC +AACTATTTTTAGTGGAAAGCAAATTTTTTCAAAATTTTGCGCAAATGGTT +CTGAGGCTCCGCCTTGAAATTGGATGCTCTTAATTAAGAAAGAAGTGTTA +GTCCCGCCCCTTTATTGGAGGAACTCAAAACTGGGAGGAGCTTAAGAAGG +TTATAAAATTTTGCTAATTAAAACACCCAGCTCCGCCCACTTATATATTA +GTTGACTCCGCCCCACCCATTAAAAGTGGGCGGAGCTTAAAAATATTGAC +CACGCCCCTTTCTTGGGTAGTTTTAGCGTTTTTCATAGAGTCAATTTTCA +CGGCGGACCCCGGATCGATGCACCATGATTTGACGCGCAACCCAGGTAGT +ATGACGTCACTCGTGGCCGAACTCGCGGGGGAAATTTGTACTTACAGCAA +TAAATTTCGGTGTCTCACGGAGCACCTGCACACGTACCGATCATGAGTGA +TGCTTCCCACCACAAGACATACACATACACACACAAACCTACTAATTAAG +ACAAATTATAGAACAAGTGGGGGGAGAAGGGTAGAAATAAAAGTGAGCAG +TGCGAGAGAACGCGTTAGACGGAGAAGCTGCTCTGGGAGACGTGTGAGAG +GCATATAAGTTGGATTAGTTTACTGCTCTTTTCATGGGAAAATCAAGTGA +GCTCCAAATATTTAATCTGACTTTGATTTGGTTTGATTCTGAAATTTTTT +TGGGATTTGCAGAAAAAATACGTTTTTTTTTTGTATTTTGGAATCGCACC +AATACGCTGCGTTGCCCTCCTACAGTGCAACTGAGCCACATTTCTCTTCC +ATAACTTTTTTCTTAATCTCAAAGATTAAAACTCTGCAAAAGCTCAATAT +TTTATAAATGATAAGGATTAGCAAAGTGTGGGTGATCTTCCAGAGGGGGG +ATTACCATAATTCATTACTCATTTTTCAAGTTTCATCTGTGTTTTGTTTG +ATAACCTAGGTGACCTACTAGTTTACCTACAGGGCTGGGACCAAAAAAAA +AATTTGGACCAAAAAACAAAAAAACAAAAAATTGAAGTTTTTGAAAAACC +AAAAAAACCAAAAAAAAACAAAAAAAAACAAAAAAAACCAAAAAATTTCT +TATGCTTAAGTTGATTTTTAATGGGGTTATTCAAGTAATGTTGCAAAATG +TATTAAAATACATTATGACGTCACAACTGTGTTAAAATACATGTTTTAAT +GTATTTTAATACATAATAGTCTCGAGTCGAGACTAGACATGGTAAACACT +TTTTTGGATTTTTTTGGATTTTTTGGTCCCAAAAAACCAAAAAAAACCAA +AAAATCGATTTTTCGTCAAAATACCAAAAAAAACCAAAAAACAAAAAAAC +CAAAAAATTCTCAGCCCTGGTTACCTGTCAGCAAATAATTTTCCCCTATA +TACCACCACTTCAGGAGTAATCAACACCCCAAAACGGCAATTATTTATTA +TTCTCCTCACCTTCTCAACACTCCATAGCGCCAGCCAGCCTAATTTGATT +GTTTAATTCGATTCAGGGCACCCCACCACACACAAATTTATTAATTTTTG +TCTTTCTCGCCATTTTCCAATAATTTTCCCGGCTTGTGTTAGCTTTATTA +TAGAACTTTTTAAAGCGATTTCTTAGGAATTTATGTGTGACGTCATATGT +GGCCTAGAAATTTGACGATCTCGGCCGTCGGGGTCGATGAACCATGTTGT +GATGTATAGGTGGCCTAGAAAATTTTAGGCCACCATGATAGTCGTGGCCT +AGAAATTTGGGCGCCTTCAGGTGGCCTAGAATGTGAAAAGTGACGTGTGA +CCTAGTTCTTTTGACGGTCAGGCCAATTTTCCAATTCGATGCTTTTTTTT +TAATTAAGGTCCATATTCTGCAATTTTAGGCTCCGCCCATATCTTGGTTA +AACATTTTTTTTTTGCTTTTTTCTGCAATATTCATTCAATCCATCATTGT +TCTCAAAATTTGATGCACCATGATATGGCAGTGGCCTAGAAAGTGCGACG +TCACTTATGGCCTAGAAAATTCGAGGATCTTGAAATGGGAGAAAGTAAAA +AAGTAATCAATGCCCCCTGACGGTCGTGGCCTAGAAAGTTAGAAGATCTA +GAGGAGGGGAGTAGGAGATCGATGCACCATGTACAGCTACAGTGACGACT +CACGTGGCCTAGCTTTTTCGCAGGCCACGGCCATAAAAAAATGTATGAGA +TCGATGCACCATGTTTGTCGCGGACTAGAAATCGAGAATGTGGCGCACGT +CACGCATGGCCTAGTGACTTTTACGGTCAGGCCGAAACACAGGACGTGGC +CTAGAAGTCATTCTGTTAGTCTAAGACTCTGCAAAAACTCTCAAAAAAGG +TGAGCCTATGTGCCTGCCTACTTGCCTACATTCTTGCCTACCTGTTACTG +CTTTCTAATCTGTACCATGTTGCACCTACAGTACCCCCTTCCGCCCCCGT +AAAGACTTTTTCAAGCTCAAAAGTGCAGAAAACACAAAAAAACCAAGCCC +AATCTACAAAAGCTCATCTATTCGTGCTTGGATTAAAATGCCATTAAAAT +GATTAATTAAGAGATCGAGACTGGTTGAAAACTGATCGGATTAAAAAGCG +ACTGAGGTCCGCGAATGAGCTTTTCATGCAACTGATGAGCACATTTCCTG +TGTATGTACACTGATGATAAATCTCCTTATCTTTTCCGAGACATAACAAT +CTCAATGTTCTTCATTAGTTTCTTCATTTCCTTCTGAAATTTGTTGCTTT +GATTTATTAAAATCTGTCATTATGTAAGATCCATAATTCGTGATTCGAAA +TTTTTTACAGTTTTTTTTAAATATAGAAATTTGAATAACTTTCCTACCAG +GCTGCCCCAATACAGTTTGATCTACAAAAAATGCAGGAATTTTTTGCCCA +AAAATATGTGACGTCGGCACGTTCTTAACCATACAAAATCAGTTGAGAAC +TCTGCGTCTCTTCTCCCGCATTTTTTGTAGATCACCGTAATACAATGCAA +AAATGAGAGAAAAAAATTTGAAAAAAAACCTATCCAAAAATTTGGCATTT +TCAGATTTTTTTTTTCGAGCAGACCTAAAAATGTTTCGATAAATTCTAGA +TTTTTTGAAAAACTGTCTGAATTTTTTTTTTTGAGAACAATGATTATATT +TTAAAGATCAGTGTTGACTTGAATCATGTAGCGTAAAAAAGGTTAAAAAA +AAACCAAGATATGGGCGGAGCCTAAAATTACAGAAATTGGACCGTAAATT +TTTCAAAAAATTTTTTTTTTTTCAAAAACCGAAATTTTATTTTAATTTCA +AAATTTCCGCTTCGGGGTTTCTTGATTTTTTCAATTTCAATTTCAATTTT +TTAGATTTTTTCCCGTAAAAAACCCAAAATAAATTTACTGAAGCTTCACT +ATTGGATTAAAAATTTATAAGGTTCTTTGCGGGAAAATTAGTAAAAAATC +GAAAATATATTTTAAAAGAAAAATCAAAATTAATACAAAAAATTAAGGCT +TCCATGTAGGTTCGCGTGGTGCCAGGCTATCCCATTATTTTTTCTTTTTT +TTTTTTTTTCCCCAGGAAAGTGTGACGTCAGCACGTTCTTAACCATGCTA +AATCAGTTGAAAAGTCTGCCTCTCTTCTCCCGCATTTTTCGAAGATCATA +CCAAAATGGGGCACTTTGACGCCACGTGTAGACTGTAGGCCATAAACCGC +CTGCCTGCCTGATTTTCAGGCTACCTACGCCTGCCTGTCGCCCCAATCCA +CGCCTTATGCTAAAACACATTCATTTCTTAATTTGATTTTCACCAAAGTG +ATAAAAAAGATAAATTAAAAATTAGTACATTCTCGTCAAAATGCAAAAAG +AGTCGTAAGGCAGGCAGGTTTCAGGCAGGCCCTGGCTCACGCCTGCCTAC +GATGCCGGTTACTAAATTTCCAAAATACCTTATTTACTCTACAAATCCTC +TACCCCGACATTACATCTCAAAACTCATCCTATTAATTTCTGCCTTAGGC +GATAGCACTACTAATTGATAGGAAAAGACGACTTGTGTGTGTGTGTGTTG +AATTATTATACTAATTTGATTTTAGGCAGCCTCTTTCGTCAAAAAAAAAT +AACTTGTGTCACCACACCACACCTCCCACGTTTTCGGTGAGTGAAGCTTC +TGCTCGCTGTTAAGCAGATATTCATAGGGAAATCATCCGTAAATCCATTC +AAGTCCTCTTTATTTTCTTCTTCTTCGACCAAATTAGTATACAGATGTCA +TCAACTTTTTTGTTTCTTTTTGAGGGCCCAGGCTGTTCATTACAGTTTGA +TCTACAAAAAATGCGGGAAATTTTTTTTTGCTTTTTGCCCAAAAGAATGT +GATGTCAGCACGTTCTTAACCATGCAAAATCAGTTGAGAACTCTGCGTCT +CTTCTCCCGCGTTTTTTGTAGATCTACGTAGATCAAAACGAAGTGGGAAA +CTCTGACACCACGTGCTTTGAGAAAAAATTTGAAAAAAACCTTTTTAAAA +ATTTGGCATTTTCAGTTTTTTTTCTTTACAAAATTTTTTTGAACGAATCT +AAAAATGTTTCGATAAATTCTAGATTTTTTGAAAAACTGTCTGAAATTTT +TTTTGAGAACAATGATGACTTGAATATTGTAGAAAATCGTAAAAATAAGT +TTTAAAAAACCAAAAAAAAATGGGCGAAGCCTAAAATTACAGAAATTGGA +CCATAAAAGTTTCCAATTTTTTCTTCACAACTTTTTTCAAAATTGCTGAA +ATAAAAAAAAACTATTATTTAAATTTAAATTTCAGAAATCCTAATTTTGA +CGCCGATTTTTAAAATTATAAGGATTTGTTTTTCCTGCAAATTCTTTTTT +AGAAACTTACAGTTTGTCGGTTTGTCGATAGAGCGTGCTTATTCACCAGG +CTGTCCATTACAGTTTGATCTACAACAGTGCGGGAACTTTTTTTTTGCTT +TTTGTCCAAAAGACTGTGATATCAGCACGTTCTTAACCATGCAAAATCAG +TTCCGCATTTTTTGTAGATCAACGTAGATCAAACCGAAATGGGGCACTCA +GACACCATTTGGGGGGCCTAGAAACCGGTCCCTTTCTCATTCAAAGTGCT +CTCTGTTATCAAGTCTCCCACGCTTTATGCATTCAACTTTGTACAGTTCA +CACGAGCACCCACGACTTGATTATTCAACATTATACAGAACTAACTATTC +GAATCTCAACATGTCTTCTTGCCGAATTTAATCAACTTTGACTTCTTCTT +CTTCTTCGACTTCTTTATACAACTACTCATCTTCTAGTTGCCCCTCTAGT +TGCCTCACACAAGCAAAATTTCTTTTGAAATGAAATTTAAACGAATTGAC +TAGTCAAAATTTCATCAATTTTCTACTAGAGAGAAGCGACGAGATTGACT +TTTGGCAAATATAGAAGAGAGAGGCACCGAAAATGAATTAGATTTAACAC +AACAACGAGTAGATGAGTTGTGTGTGTCAACGATGATGATGATGATGAAA +AGAGCAGAGGAGCAAGCATGAGTGATTTCTGCGGCGGAGGTCGCGGCGGA +TGAGGAGCATGAAGAAGGCTAACGAGCTGTATGGCGATGCGGCTAAAAAT +TGATGATTACTGTAGATTTGGAGCTTTACACCGTTTAACTGGCTACGATT +ACATACAGACTTGTTTTAGAATATTCTGTATTTGAACCTAATAATACAAA +TTGCCGGTGTGCCGATTTGTCGGAAATTTTCAATTCCGGCAACTTGCCGG +TTTGCCGATTTGCCGTAAATTTTCAATTCCGGCAACTTACCCGTTTGCCG +ATTTGTCGGAAATTTTCAATTTTGGCAAACTGCCGGTTTGCCGATTTGCC +GGAAATTTTCAGTTCCGGCATTGTGCCGGTTTTCCGATTTGCCGGAAATT +TTCAATTCCGGCAATTTTCCGGTTTGCCGGTTTTCCGTTTGCCGGATAAC +AAAGTGTTTAGAGGGATTTTTTTATAAGAAGGAAACTCTTAAAACTGTGA +CTTTTTGAAATTGTTTCCCGTTTTCTTTCGATATTTTCATAGATTTTGCA +AGAATGCGTGCAGTTTTGCCAGTTTAGACGTAATTGAATTTCTGAAATTT +CAAAAAAAAAAGAGCAAAATCATAAATTTTTGACATTTGTCATTTTTTCC +GGTAATTTGGCGATTTGCCGGAAAAAAATCATTTACCGCCAACTCATGGT +ACGTCTAACCGCAAAAATTTTTTGGGAGCCTTTTCTGGCTTTCTTTCAAG +CTATCGTAATGTGACCACACACCTTTCTATAATTTTCAGTATTTACGCCA +ACCGAGAAGATCACAGTAGTTTAAGGTTATGGTGCAGTTTCTGGTCAATG +GATCAGGTCTCTTACCGCGAAAATTTTAATACCGTGAATGTGAAGCTTTG +AAAATTTTCTGCCGTAAATTGTCAATTTTCTGCCGCACTTTGTCAATTAT +CTCATAAAGGTCACTTAAGTTAGCCAAACCGTGAGCCAAAACTGCCCCTT +ATTCCTCATGCCGTCTTGGAGGAAATCTAGAGCAAACCCTGGTCCATATT +CGGACAAGGTCCCCTTTCTTCCCCCAAGCGTCTATCTAACTTTTCCTAAC +TACATATAACGGAATTAATAATCCTATCCCCAATTTAACGTGTCCTTAGT +TCTCTCCCTCCTCACCGTCTTCTAGTTTCATCCATGTCTCGCCTCATTTC +ACCCGATTGACGATCATCTCGGCTCCACACTTTGACACCATAGCGCGAAT +GAAAAAAAAGAGTGAGAAAAGGGGAAAAAAGTTGCTGCCCTATTATTAGG +AGTCAAATAGACACACACACACACACACTCAATTTTAATGGATTACGCAC +GATTTGACACCATCGACACCAATTTGGAAATGGGGGCACATAGATACATA +CACAAAAGGAGTTGTACTACTAGTTTTGGAACTAACATCATTCTAACATC +TTTTCATTTATGATTTGATTTATGCAAATGTCCTTGATTCGTGACTTCTT +GTATAGTAGTTGGGATAAGTATAATCATGGTAGTTGCTCAAGACTAAGCT +CTTTAGCAGTTTTAAGGTATGCCCCAGTTCGGGATTCCGGCTTGCTTTAA +GATTGTGTCAGGTCCGGCCCAGGTTGTCTAAAAAATACAGGTCTGCTCCA +GGACGGTATACCATCACTATATATAAAGCACGTGTCGTTCCGTCACTTTG +TAGTTTGATCTTTGATCTTTGGTCTTTGAACTCTGTAGTTTGTAGTCTCA +TCACACAAGAGAGGTCACATAGGCCCGGCCCCTTTTGTGACGTCATCACA +AATTGGCGGGAAATTCAAATTTTCTGAGAAAATATTTTGGCGGGAATTTA +AAATTTAATTTTTTGAAAACATTTTGGCGGGAATTCAAAATTTAATTTTT +CAAAAACATTTTGGCGGGAATTCAAAATTTAATTAGACTGTTCTCGGTTC +GGCCCAGATATATCCAAAGTCTTTCTCAAGACCACTCTAGATCTGTTCTA +CTGTTACCCAAGACTGCCGCTCCACACCCTGTATAAGTTGGCCCTAAGGC +TCCACTGAGTTTGATCTAAATCTTGCCAAGCCTGTATCATACCTACCTAG +GCCCACCACAGGTGCATCTCTCACAGATCTTCCACAGGTGTTTCTAAGTC +TGCATCAGATCTGCACCAGGTCTGTTTTTAGTTTTGCCTGGGTGCAGCCC +AGTAGTCTACCTCACTATCAAGCAGGTCCTGACACCAGTTCCTAGGTCTC +ACATTCAGGCTTCTAGGCGGATAGTCTACCTAGCTAAAGCTTCAACCTCC +ACTGTTTTAAAGGCTTCCCCTTTCTCAAACTTCAACTAACATTAATACAT +ACATATGTTATTAATTCGCGACTCGGCGACTAATAACAATAATTCAAAAC +CTCTTTCCTGGCAATGCTTCCGGTACTCAACACGGAGAGAGAGGTGGCAG +GTATCCGGTAATTTATTAACTCGAGCCGCGCACCCTGGCTCCCAGAGCAC +ACAGCCCCGATGATCGCTCATGCACGAGTACTCACGAGGTGGTGGTGAGA +GGTAGGTTGGAGAAAGCGGTTCTACCTTCACAAATTTCAATTTCAATTTC +CTCTCTCTCCGTTTTACTCGGGCCCCCCCCCCCCCCTTCTTTCAATTTTT +CGCCCCAAATTTGTGCTCCTTTAATGGAAAGTTTTTGAGTGTGTGAAAAA +GAGAGAGAGAGAGACACCTTCGTGTCACGCCAATTGCACTAATATGTGCT +CTCCCCACCTAGAGCTACCAAAATGTTCAATTCACAATTTCCGAACTAAT +TCGTGTCAAGTTTTTAGTTGGTCCTAACTCTTTGGCCTAGAAATTTAGAT +TTCTAGGTCATCCATCTAGATGCGGTGGCCTAGAATCCTAAGCTTTAGAT +GCCCAGGCCATCAGGCCTAGATTCTGAAATGTTGTGATTTTTCTAGGCCA +TCAACTTTGACCCAAAAGCCCTCTAATTTTTAGGCCATGAATCTAGGAAC +CTATCTAGAGGCCTGATCCTTTGCTTTCTTGCCAAAAACTAGAGATCAAT +GCCCTAGAAGCTCACAAAACTTTGGCCTAATAATTTCTAGGCCACCAATT +TTTTAAAGATAGCCTAAGTCATCAACCTAAAATTCACGGCTTAGAAATCA +TGAAATTCGCTTTTAAGGCCTCTGACTTCATAGCAGTGGCCTAGAACTCC +AACTGTCAGTAGTCTGTAAAAATGAGCTTTTTGGGCCTCGAACATAACAT +GGGACATGGAAGCCTAACATTTTTAGGCCACTGACTTTAAAGCAATGGCC +TAGAACCCCGTTTTTCTGTAGCCTAGACTATCATCTAGAAATCAATGGCC +TAGAATCCTAAAAATAATATTTTTCGGCCACCAAAATTTTAGGAATGGCC +TAGAAATCTATTTTGTTGTATTCTAGGCCACCATCGACAAAGGAATGGCC +TAGAATCCCTAAGAATGTGATTTTTAAGCTACCATCTATGTACCCTAGAC +CAATATTTAAAATTCAATGGCCTAGAAACTAGAATATTTGATTTCTAGGC +TACTAACTGTTGTGTGCTGTATCCTAGACTATCATCTAGACCCCAATGGC +CTAGATTCCTGAAAATGTGTTTTTTCGGCCTGAAATAGGCCTAACATTTT +CCAGTCCACCAACTCTTTTAAGATGACCTATAAGTTTAATCCTAGCTTGC +CAACTATAAATAATTGGCCTAGAAGCTCCTAGGCCACCATCTAAAAATCG +ATGGCCTAGAAACCTCCCATTTTTTGTATCCTAGGTCACCAACAACCACT +GATGCCCAAGACCCCGGCTTCTTATTTCATAATGAGCAGCAAAATGAGCT +ACCGTACCCCTTCTACACACTTCCTCCCTCTCCACACCCATTTCCCCTCA +TTTTCGTCTATTTTAGCGGCGGCGGCGCGGGATAAATTTGTGAGAGGTGA +GCTGCTCACAATAATGGGCTTGTTGTAATAGGCGGCAGTGGTAGTGGTGT +ATGGATAATTGTGAGTTCCCAAACACACAAAACTTTTTCGCCGCAATTGT +TATGCAACCAACATAATAATAATAATAATAATAAGTGAATGTGCATAAAT +GTGCTCTTTTTCGCGTCTCCACACCCGTCCTGATGGGGACGACGCTTCGT +TGAATAGTTGGAATAATAATAATAAATTGGAAAAATTTGGGCGCCCCCCT +CCTAACACCCTAACACACACGAAATTTCATTTCGCGCGCGCTTCGAAAAC +AAATTGAAGACAAGTTTTTCGCGAGACAAGTTATGATAATTTGTGGGATG +TGGTCCCCGCCGGCAGCTTCCATCAATTTGGAGCAAATTTGTGCTCTCGC +AAACCTTCTTAAAGAAGGGTTACACTAACAAAGTTTGTCGGAATCGATAT +TTTTGTAAGTGGGCCTGAACCCCCGGTCTTTAAATTGATAGGCATTCTAG +GGCTTCCATGGGAGACAGGCGCGGTTTTAGGGCCTGACGTCTGCCTCTCG +CCTCATTTCTGCACTATGGCGAGAAGCCAAAGACTTGGTGTTCACACTTT +GTGCCAGAGTGTCTCATTTCGGCTTGATCTACGTAGATCTACAAAAAATG +CGGGAGAAGAGAAGCAGAGTTCTCAACTGATTTTACATGGTAACCAGAGC +GTGCTGACGTCAAATTTTTTTTGGACGAAAAACTCCCGCATTTTTTGTAG +ATCAAAAACCGTAATGGGACAGCAGGGCTTTCCACCAGAATAATTCCACT +TCTTCACAATAAACCTATATATTTTTTGTCAAAATCTTGAGAATTTCCAG +AATTTCAACGAAAACCACTGCTAAAAGTGGTTCTTTCGCCGCGGCCGACA +CTTCTCGGGTTCCGCGCCGCACTATAAAGGAGGCGCGGCGCGGCAGGCGG +CGCGAGGCAGGCGTTTTGGCGCCTGCACGGATGCCCTACACCAAACTGCA +AACATTTCTAGTTCCGTTTTTCGGACTCTACGCCTTATTTCGGTCTTTTT +GTCACAACTTCGCTACACTGTGTTTTTCTCCACTTCTACGACTTTAAAGG +AGGGCGCATTTATGCGACTCACGTGATGTCAGGCAGTCTCATTGCGGTTT +GATCTACAAAAAATGCGGGAAACTTTCCACCAGGAAATTGTGACGTCAGC +ACACTCTTGCGAGATCAGTTGAAAAGTCTGCGTCTCTTCCCCCGCATTTT +TCGAAGATCAAACCAAAATGGGACATTCTGACACCACGTGGTGACTTAGG +ATCAATGTAGATCGTTTTATAGGCCATCCATTGATTTTTAGAGCTCGTGG +CGGGACCATTTTAAATGAATTTCCAAAATTTCCAAAAACCTAATTTTTTT +GTCAATTCACAAGTCCCCCGGACCCCCTCCATTGTCCCCCCGTTCACAAC +TTCCTCCCTCGTTAACCACCCATTTAGCGGGACAAAATTAGCGAATCATT +GACTCATAATCAAGTAAATCGGTGAATGCTCGACGAGCAAGAGGGGGGGG +GGGGGGTCTAATCGAATTACGGGGGAAGGGACCCCTCCGCGCGACACCTC +GCTGCCAATTAACAAGTCAACTACTTGGGGGGGGGGGGGGGCCTCCTCAC +AACAATGTTTGTATTATATTTCTTGTTATTATGATTATTATTATTATTAT +TATTAGAAATTAGTTAGTATGAATATATAATATCAACTAAAAACAAAATG +ACAGTTAATAATAATTGAAGTCATCCAATAGGTGCCAATTAGTCAAAGAG +AGGGGTCTGTGAAAACAGAAATAGAAGAGAGAAGGCGGGGGAGAGGGGCG +CTCTCAAATAATTAATCTGGGCTCCGTGGGCTCGTAAAATTCCGATAAAA +TGGCTTGTTTGTAATTAGCTAATTCACGGAATCTTTTTTTTTTGTTGGGG +TTTTACTATGTTTTTGAACAACTTCCTGTTATAACATGTTTCAAAAAAAC +TATTGACCTCAATGGGGACTTGAACCCTGGTGTTGAGATTGGTAGTCTGT +TAACCAGTACACCAAAAATTGCAATTTTTGATTTTTGTTTTGTCTATTTT +TTTGAATACAACGATAAGTAAGGATCATTTAGATTTAGAAAAAAAAAATC +AAATTTTGTAAAAATTTTCTAAAAAGTTATGAACATTCCACTTTCACAGA +TTTCTGGCTTCCCTCATAAATTGAAATGGAAGAGTTTTTGGCGAACAAGG +CCAGATGCGTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTAATGCATT +TGTCCGTGTGGAGTCCACGACTTCCCCCGTTGTCCGCCAGACGATTGTAA +ATGGAGCGCGAAAAATTCAATGAGAAAGGCCAGAACCCCGTGCACTTTTT +TGTTTCTAAAACTGAAAATTTTGAATTTTGAAATTTTCCTTGGTTTTACA +GTATACAAAATCTTAGTTAGAGTTCGCAAAAATTATTGACACTGGTGGGG +GCTCGAACCCCTGAGGTGGCATCCCTGTTAGCCACTGCGCCAAAATTGCT +AAAACTTCAAAAAAAAAATTTTAGACCGTTTTTAAGGTTTTTAGACTTCC +GACTCTTCAAAAATTCCTATACAAAGTCTTCGTAAAACTAATGACTGGGG +GGCTCGAACCCCGGTCATCATATCAGTAGTCATCCCTGTTAGCCACTACA +CCACTTGCCCAGACGTGTTTCTGGTCTGTTTTACGGTGCAGCGTGGCCTA +AAAAAAACTAGTCAGCCACCAATTCGAAAAGTCCATAGACCAAGTTAATA +TAGAAATTCTTCAAATTCGAGCCAACCAACTAATATATTCACTAACCTAT +TTTCGCCGTGTTCTTCCTGTGTGTGTGTGTGCCCCTAGTTAGGCCTAGCC +CCCCCCCTTATTTTACTTGCTTCACAATTCAATTGGCCCCCACACAGTTA +CAGTAGTCATAATCATTTTGTGTCGGGTTTTCGACACATCGTTTAAACGT +GTTACCTCTCTCGGGGCCCCCTCTTCTCCTACTTCTTATTTGCTCAAAAT +TTGCGCGTCGAAATTTCTTCGTCGTGCGCTGCCCCTTCCGAATAATCAGA +TTCACCAATGTATAAAATAGGCCACGCCTCACTTTTTCCACACCCATCAT +CTTCCCTCAACTTTCCTCTTCTCAAATGCCTAATCAGCCAGTTATAACGA +GGGTGCTCTTCGTGTGGCGCCCCGCCCATTTTATTGCTCCTCTCACGCTT +CATTCTCACTTTTTCTGGGGATCCTTTTTTTTGCAGACCTAAAAATTTGA +GCTCAGCCATATTTTTTTTGTAAATATAATCAAAAAAAAATAGACATTAG +TCAAAAAAGTTGTTTTAAGCCTAAAAAAATTTTTCAGATAAAAAACGTTT +TTCTTTAACTTTTTTGAACAGTTTTTCAGTGAAATATTTTTAAATTTTTA +TTTTAAAAAAATGTTTGTTTATCTAAGCCTAAGCCTGAGCCTAAGCCTAA +TAACCCTAAATAGCGTCAGTGTGGGAGCTCACGCTCCCCCACTGACGCCA +AGCCTAAGCCTACGCCTAAGCCAAAGCCTAGGCCTAAGCCTGGGCCGAAG +CTGAGACCTAAGCTTAAGCCTAAGCCTAAGACTAAGACTGAGTTCAAGCC +TAAGCCTAAGACTAAGCCTGAGTCTCAGCCTAAGCCTAAGCCTAAGCCTA +AGCCATTTTTAAAAAGCTTAAAAATTTTTGCAATTACTATTTTTTCTGAA +AATCTGTAAAAATATCGAATTTTTAGAGTTGCTATAAAATTTAAAATAAT +ATTCAAAAAATAATCCGAAAAAATTAAATTTTTTTTCTCAAAACGTAGAT +CATACAGAATCAGCTTTAAAAAATTCAAACCATTTTTCGTTTCAAAAATG +TTCAGAAAATTTGTAAAACTTGAGTTTTGAAGAAAGTTTTCATAAACTAG +CTCTTGAATAGGGTTTTTAAGTAGGCGTTAAAACGCTTGCCTGCCTGACC +TTCAGGCGACTTTCGCCTGCCTGCTTGACTTTCAGACGTTCTCTGCCTGC +CTGCCTGACTTTAAGGCGACCTCCGCCTGCCTCTCGCCTCAATCCGAGCC +TTATCTCTTAAAATGTTTTTCATCAAATTGATAAAAATACGGAAATTACA +AAATTTTGTAAGTTCATGCCAAAATGCAGGCATCAGGCCCTGAGGCCACG +CCTGCCTAGGCCTCCGACTTTCGTTCTACAATTGTCGTTGCCGTTTCCTT +TATCCCATTTTCATACCCCAAAGTTATGATTTTTCTTACACCCCTTGCGC +TGCTGCTGCTTCCGCTCCCGTGATCTTATGAATCAGTAGTCAGAACTGCA +GGTGTGAATCTCCACAATGATCACCCAATAAACGCGAAACACCATTAGAA +ACAAAGTGTCCCCCGTTTTTTTTTTCTGAGAGTGTCGGCACCCCCCTAAC +ATATGCGGGGAACATTGTCTCAAGTTTTGTGTGCTCCTCCAGCTCCTCCA +TATGGTTACCGTAGTCCCCTGTCAGTGTTGTGTAATTGTTGTTGTAACTA +TCCCCCGAATACCTCTCCTCACATTCATTCACAACACAGGTGTCAACTCA +ACTCTCAGTGCTCATTTGAAGTTTATGAAGTTTAGCTTCCGGGGATGGCT +CTCCTGGGCTCCCCGCTCCCTCGAAAATTTAATTAATTGCAAGCACATGT +GGTGGTGGTGGGGCGAGCTCCGCGCTTCCCCCCCCGCCCCGATTCTCTCT +CTCTCATTTGCGACTCATTAGATTTTAAATCACTCTCAAACTTTCCACTT +TTCCAACTTTCGCGTTTTTTAAATTTTTTTTTCACTTTTTCCTCACAAAT +TCATCCAAAAAAATTTCCAGAGTTGCCCCGCCCATATATTGGCTAAATGG +TAGAATGGACGTGGCACTTTTGACAATGGATGACAACAACAAACCGCCGA +CAAGTTCAGAGTCTACGGAGAGTAGGGGTGAGTTTGGCCGGGGGACCGAT +AATTTTTAGGCCAAGACTTCTTTTTTTTTAAATCATTTTCAAAGGTACGT +TACCTTCACGTGGTGCCAGGTTGTCCCATTGCTTTTTGATCTACAGAAAA +TGCGGGATTTTTTCCCCAAAAAATGTGACATAAGCAAGTTTTTAAATCTT +TTCTCCCGCATTTTTTTGTAGATCTACGTAGATCATACTCTGACACCACG +TGTACCTTGAACCTCCTGGCTTTCTGAAACTAGAGTTCGTCGCTAGAGCG +CATTTGCATTGTCGTGGTATTTAATTTACAGTACCGCCAGAATCATGTCG +CGCCGCTTGTAGTCTAGTGGTTAACACGCTTCAGCTCTAAACAATAGGTC +CGGGGTTCGATTCCTTGCAAGATGAAATTTCTTTCTCAAGATGGAGGTAC +ATATGTGCTTTAAATGTGCACTAGAGATAGCGAAACTGATACCATGGTCC +GACATGTACAGGGTTCCGCGCGCGCCTAGGGCCTCCAAAACGCCTGCTGC +TCCAGTTTTGCGGCGACCTCCGCCTAACTCGCGGCGCGCCTTCTGTATAG +TCACGGCCTTCTGTCTTCCCTCATAAATTGAAATGGAAGAGTTTTTGCCG +AACTAGGCCATCTTGGCTCGGTCACATCTGGGCTCGATTTTAGTTGTAAA +ACTAAATGTATTTGTCCGTGTGGAGTGCACGACTTGCCCACGCGTTGACC +GGCGGGCGATTGCCAATGGAGCGCGAAAAATTCAATAAGGAAGGCCAGAA +CCCCGTGTATAGTGCCGCGCGTGGAGCCCGAAAAGTGTCAGCCGCGGCGG +AAGAACCACATTCCATAGGACTAAAAAACTAAAGTTCTCTCTTTCAGAAA +CATCACCACCAATGATGCCAGATTCTGCGGAGATAATGCGACTTCTTACG +GATCCTTCGACGGCTCAGATGTTTGGTAGGTCATAGATCAAATTTTTTCC +GCAATTTCCCGAAAAATTTCAGCCAACGAAAACACAAAATGTCAGCTGGG +ACGGATTCTCGCCGCGTCAGGCTTCGACGAGGCGAGCCTCTCCTCCTCGT +TTCCGTTCGATCCGACGCTCGGCGCGTTCGCCGACATTTCCCAATTCTCA +TCACTCCGAAATTCGTCGAAAACGCTGAAATGTCCAAAGTGTAATTGGCA +CTACAAGTACCAGGAGACCCTTGAAATTCATATGAAGGAGAAGCACAACG +ATGTGGATGTCAAGTGCATGTTTTGTGCCGAGAACCGTCCCCACCCGAAG +CTGGCTCGCGGTGAGACGTACTCGTGCGGTTATAAGCCATATCGATGCGA +TTTGTGTCGGTACAGTACGACGACAAAGGGCAATTTGAGTATTCATATGC +AAAGTGATAAGCATCTTCATGCAGTGCAAGAGCTCCCGAATAGTATAGGT +AGGTGGGGGGGGGAGGCGAAGGGTACTGTAGTTTTCGTGGTGGGACCCAA +GAATTTGAATTTCACAAGAATTTAACTGTTGAACTCGAACTTTTCGATTC +TAGGGTCTCGCCACGCAAAAACACTTACGCCAACTTTTTTGAACCCTAAA +AAATGATACTCAAATTAGAGTTCTCAGTGAGCTAAATTCGATTTTACAGT +ATTTTTTTAATTTGACGTTCTGTGGGTCTTACACTCAAAGGGTACTGTAG +TTTTCGTGGTGGGACCCACTTGTCCAAAAATGGACGTGATTATATTTGGA +TTAAAGCCCCTAACTTTTCTGATTTTTTTAATAAATTGGTTTTATTTTGA +AAAGACTGAGAAAATTGAGTTTAGATCGAAATCAATAAAAATCGCGTCGA +GACCCAAATTTCCCGGGTCTCGGCACGAAAATGGGGGAGAGGGTACTGTA +GTTTTCTGGCTTCTCTCATAAATTGAAATGGAAGAGTTTTTGCCGAACTA +GGCCGGCCATATCTGGGGTAGATTTACGGCGCGTTGCGTGTCGCGGCTCA +ATTTTTGTTTTAAAACATGAGGAAGACCAGAATCCCGTGTTTTCGTGGTG +GGACCCAAATGGGTCATGATTATACTTATTTGAAAGGCCTTAAGCTGAAT +TCAGATTTAAGATTTTTATTATTTTAATTCAAAAATATCCTGAATTTTCC +AGAATTCGCAGCCAACTTCGCGTGTGGTGCTCCAGTTAGCCGAAGTAGTC +CAATCGAAGAGTCCGACGGATCCCTGGTCTGCTTGATCTGCGGTATCTTC +GCCACCGAATCTATCGCCGAAATGATGGAACACGTGGAACAAGACCGTTC +CAGGACGTTCCAAGGAGACGTTACCGTCCTAAACGGGAGCTTCCGGTGCC +ACTTGTGCCCGTATAATACCACATTGAAAGCCAATTTTCAACTACACACA +AGGACGGATAAGCATCTGCAAAAGGTTCAAATTGTGAGTTTTGTATTCCC +CTCTCATCATCTTCTTATTTTTATTGTGTCGCCCTTTTCCCATTTTTGTG +TGTCTGTGTGTGTATGCGCACCGATTTGCATATACACATAAATTCATGAT +TTAATAGCGTAATGAGTAATATTTGCTTTGCCAAGGCTAACAGTTTTCGT +ATTTTAAAGCCTTTTTTCTACAATTTTTGAAAAAAAAATTCAAAAATTTG +AACATTTCAATATATCCCTAGAAAGCTCAAAATTGTAGTGAAAATTTTGA +ATTCAGTACGCTGAGACCTTTAAAATAAGTATAATCATTACTAGGTTTTG +GTTCTGACGCGAAAGTGTTCGTGGCGGAGCCCAAGCAAGGCGTAATTGAT +TATAGGGTCTTTGCACGCAAAAAATTTAAGGTCCGGTAGGCGTGGCGGGG +AGTTTTTCTTGAATTATTTTAGTTTTTCATAAATTTTCAATTTTTTGGAA +TTTATTTTTCTCTCCCTTCCCCCGCGTAGTCTGAGCCTAAACCTAAGCCT +GAGTCTAGGCCTAAGCCGAAGCCTAGGCCTAAGCCTGAACTTAAGTTTAA +GCCAAAGCCTGAGCCTAAGCCTAAGCCTAACCCTAAGCCTCAGCCTCAGC +CTAAGCCTAAGCCTAAGCATAAGGCTAAGCCTAAGCCTAAGCCTGAGCCT +AAGCTTTAGTCTAAGCGTAAGCCTAGGCCTAACCCTAACCCTAAGCTTAA +GCCTAAGCCTAACCCTAAGCCTAACCCTAAGCCTGAGCCTAAGCCTAAGC +CTAAGCCTAAAGTCTTCGTGTCGAGACCCAATTATACTCAATTGAAAGCT +CACAATGAGCTGAATTCAAATTTCTCAATGAAAATGTGAAATACTTTGAT +TTTACGGTCGGTGGCTTTACTCCCCCCGAACTTTGGAAAAAACTCTGAAA +TTTTTTTTTCATTGAATTCCAACCGGTTTCTACTCTCTCCGGCTATTAGT +GTATGTGTCTTTCACTTCTTTGTTCTCGTCGGGTTGTTCCCAATTTCCAA +CCCTCGTTTTACTCATTCCCCCTCTCATTTTCCCAATCCAATTAGTTATA +CCTATGGGGGGAGGTGACGGTGATGATTCTCGCCATTAAGACCCCCCCCC +TCTCCTGGGCCGATTGAGATGGAAACAAAACAAAACTGTCAATTTGAATA +AATTCGCAATTTGACGCGGGCGGCGCAGCGGGTTGCCGAGAAGGATATAA +ACTGGGGAACTCTACTTAGCCCGTAAGGTGTCGGCTGCTACTATTTTATC +ACATCTCAATTTTTACGGAATCCCGTAAGGCGTCGGCTGCTTCTCTGTTT +TTGCATGTTTTTACAATTTCGGCCCGTCCGATGTCGGCTCCTTCCAATTG +TTTTGCAAAACAATTTAAAATTTGAGCCAGCAAGGTGTCTGCTGCTCCGG +CTAGATTTCCAATATTTAAATTTTGCACAATCCTGTAAGATGTCGGGTGC +TTCTCAGTTTTTACAAAGTTTTTTCTCAAATACGGCCCGCGCAGTGTCGG +CTGCCACCTCGTATGTTTCATCAAACTTGAACGATTCGAGCCCGTTAGCT +GCCCGCTGCGTCTTTTTTTTTCTCAAAATTCCAGCCCGTAACTTTTCGGT +TGCTGAAATAAACAAAATTTTTACGAAATTTTAACCCTTGAAGTGTCGGC +TGCAAATTAAGATACCTACTCATTCAGATTCCCGTCTCTCCCTCTCCCTC +TCTCTTCATTGGGGAGTCCTTCTCCCGAGAGAAAATGAATAAAACTGTCA +ATTTGAATAAATGCACACAGCGGGAGATGTTTTTCTGTGAAGACTCCACC +GTCTTCTTCGTCTTCTGCCTATTAAGCGATGATCCTTTCACTTAACTGTC +GTTCCCTCCCCCTCTCCACATACCAATAAACCTTGCCAAAAGGTCGAGTA +TGCTTTGCCCGCCATCGTGCCGGAGGTCTTTTTTCTAGACTATGATGTTT +TTTTTTGGAAAAACATTTTTCTATGGATCGATGCACCATGATGCCGAGTT +GCCGAGTTTTCAATTTAATCAATTTTGAGATTTCAATTTTAGTCCCTTGT +ACATATTAATTTTTTTGGAATTAACATTAAAATTTGATAAACTGTAGCTA +CAACTATTTATTTTTGTGCCAAATTATACTATCCAATTTGACTTGTCTCT +TGATGCACCATGACTAACTTTCTAAGATCTCATATTTTGGCCTAAAATTA +TTCTCAAATATTTAAATTTAAACTTTAATCCTATTTTTTTTAATTCCTCG +GAAAAAACCCCGTTAACAGAATTCCCAATTTGGCCTCCAGGAGCTTTTGT +CGATGCACCATGTTCAACATTTTTTCAAAATTTTGCTCATTTTGACCTGA +AATTTTGTCATTTTTTTATGTTGCAGGGTTTTTTATTTTGTGATTTTTGC +GATGAAAACCACATTATGTGGATGAAAAAAGTTTGGAATCTAGTTTTCCC +GTTAGGCTGCCATATTGCTATGTAGTTGATGCACCATGTCCAGCTTTCTG +AAATTTTACTTTTTACATTTTTTGCTCAGTTTGACTTTAAAATTTTGTTA +GTTTGACCTTAAAATTTTGTCAGTTTGACATTAAAAATTTGTCAGTTTGA +CCTTAAAATTTTGTCAGACATATAATTTTTTTGTGTTTTTTGGTTAAAAA +ATTGAAGGTTTTTCGCGATATTTAACACATTACATGGAAAAATTCTTTTG +ATCGAGTTTTCTAATTTGTTCGTGTAGCAAGTCGATGCACCATGTCCAAT +TTTTTAAAATTTTACTTTTTTTAAATTATTTGCCCAGTTTGACCTTAAAA +TTTTGTCAATTTTACCTTAAAATTTTGTCAGTTTTACCTTAAAATTTTGT +CAGTTTGACCTTAAAATTTTGTCGGTTTTACCTTAAAATTTAATCAGACA +TATAAACTTTTCTGTTTTTTGGGTTTAAAAATTGATTTTTTTTGCGTTAT +TTAACACATTAAATGGCAAAAAATCATGCACCATGTCTAACTTTTTCCAA +AAACACTTGATTTTTCCCTAAAAGTTTGTCAGAATTATACATTCCTTAAG +TTCAAAACCGTACGGAAAAATTAGAACCCATGTCGATGCACCATAAGCTT +TGGCTCGCTGAGCTTCGTTGCTGCTCCTGCATATCTCTTACCCCCTCTCG +CCGCTCTCAGAACATTGACCAATTACTTGGGCGGAGCGCCGTTTTGAAGT +CGATTGGCTGATGAGTGTCCCGCCCCGCCCCCCGTCCCGCAAATTTTCGG +AGGAACTTTGCACTGCACACACACACACACAAATACACAAATACACGCCA +ATTATTGTCGATTTTTCTTGAAAATTTCTTCATTATTGTATATTGACTTT +TTTTGTCGTCCTCTAGTCTTCCGCCATCCTCGGCGTCTTCATTCGTTTCA +TTATTTCATACACCTGTTACCACTTAATTCGCCTATTATCCTCCTCATTA +CCTTCATTTTTCGGTCGGCGTTGACGTCGACATTGGCGCCCGAAATGAGA +GGAATAGGGGGGGGGGGGGGGGGGTATAGACGACGGCGACTACGACAACC +ATGATGACGATCATTTTCGTTCTATTCATCTAATCCTGCTAACCGTCGAT +TTGTCCCCCTCCGTTTTTCAACTTACCAAAACTTTTCGGTTACCTTGGGA +ATTGGTCCCCTTTTATAGGCGCGTAAATTGACAACATATTTTGCTCACTT +TTTCGAAGTTTCACAATTTTTAGTTAGTCCGTTTTTTCAATCTGGCCGAG +TTTTCAATTTTCCCCGGCCAGGGAATTCTAGTAGTATTCACATAATTTTT +CTTATTTTTGGTTTTCTAGGCTACGATAAAACTCCCTATGCCCGGCAAAA +CTTCTAGGTCCCCCATTTTACACCTGACTTCCTACCTATCTGAAATGCCT +ACTTGCCTTTCCACCTGACTAAGATGCCTACCTACCTAAAACCTACCTAC +CGAACTATAAGATGACTCCTTACCTACATAAGACTTGCCGATCTGAAATA +CCTACCTACTAAGACATGCTACCTAGCCTACCTATCTAAGATACCTACTT +ACATATAATGTACCGACACAAGACTTGCCTACCTACGCAAGGCATGATTT +TTTAGACCTACCTACCTGTACTTAAGATTTAAGACCTAGATCTTATTACA +TAAGAATTTTCATCTTAGATACCTACTCAAGATCCTACCAAAGATGCATG +CCTACCTATGACCTACTTACTTAAGATACCTGCCTACCCAAACCATACTA +CCTAGCGCTAGCGCCCACCTACCTAAGATACCTACTTACCTATAATTTAC +CTACACAAGACTTGCCTACCTACGCAAGGCATGATTTCTTATTGTTAGAC +CTACCTACCTAACTATAAGTACTTAAGATTTAAGACCTAGACGTTATTGC +ATAAGACTTTTTGTCTTAGATACCTACTCAAGATCCTCTTACCCAAGATA +TACCTAGATGAACTTCCGACCTAAGATGCCTACCTACCTAAGCCCTGTCT +ACCTAAGACCTACCTATAAGAACTTCCTACCTAAAAACACCTACCTAAAA +TAAGCCTTCAAGCTCAAAAATTTTTAGAGCATCTGCATGAGATAAGGCTG +AAAAATATTAACGAATAAGTGGAGAGCGATTAAGTTCCTGCCCTCTTAAA +GTTCGGAAGTAGGCGCCGCAAAACCCCATTACTATTGCTCATCGAGCCAT +TTCCGGTACTCAGTACTTTTTCATCCCCCACTCACTTTTTTCTCTCTTCT +CGATTTGATTTGCATTCTTTTTCCCCTCGAATTTCGAGCTGAGCCCGGTT +GATTTCCCGCACTTTCTCAATTCTTTCCTTAAGCCACCCCACTTGACCAG +GAGCAGTTCATTCAAACTCGCACTTAATCATATTATGACCCCCCCCCCCC +ACCCCTCTTAATTTCCTAATCCCCCTCCCCCTCCTCCTCATAATGACCAA +AAGACAATTGCAGGCGAACCATCTTCGTGAGGGAACCCGTCCGCACACGG +CAATCTACCGTCTGTCGAGCACAAAGACGAGCGTTCAAGTGTTGTGTCGA +CAGTGTCAGGAGGTGATTTCCAGTGGCGAATCGCTCCGCGAGCATCGACA +CTTTCACGCCCTGCTTGCCGCCAAGCAACGCTTGTGGCGATGCAAGTTGT +GTAGGCTGGAGTTCGACTCGGTTCTTCTTGCAGCTGGTGAGTCTTGATAG +TTTTTTTTAGGAAGAAATTATATCTGTAAGTCCCCCAAATATAAGGCCCC +CATGTCCATCTTAATGAAGCTTCTGACTTAATTTTTACTATAGATTTTGA +ATTTTGTCTATCGGAAGAAAAATTAGGTTCACCATGATTTTTCGATTTTT +TCGATGCACCATGATTTGTTGCTAGAATAGAAAACAATTCGTGGCCAAGT +TTTTTAATTATTTCTTTTTGTCGGCCAAGTTGCAAAAGTCACCTTTTGTG +TATGGATGCACCATGACCCTTTTCAGTGGATTTTGGCCCAAAAATCGTCA +AAATTTTGAATTTTTAAAAATCAAACTCTAAATTACCTTTTTTTTTCAAA +TTTTCTTAACAAATTGGAGCATTTTAGAAAGTTCCGATGCACCATGATTT +TTGCTAGAATTGAAAAAAAAATTGTCGGGCAAGTTGCAAAACTCACATTT +TATGTATCGATGCACCATGACCATTTTCGAAATTTTGCGGTATCTATTCA +AATAGTGCACATAGCCGTAAAACATTGGTGGTGGCCTCGTTTTCTCATGC +TTCGGCCACGAAAAAAAAAATTCTACAGTTTTTTGGATCGATGCACCATG +ATTATTTTTCAGTGAAAGCCTGTTTTTGCTTAGCTCAAAGGCCGGCTTAA +TGTTCCCACAAAACGTAATCCAAAAATTTAAATTTTACCGTCAAACTTTT +AGCCTGGCGTACACTAAAAATTGTAAAGTTTCAATATATCAAAAATATTT +CTGGCCTATAAAATTAAACCTGAAAGCTTAGAAATCCAAGATATTTTTTA +AAAATTGATGTCCAATACATGGGTGTGCAGCAAATCTTAAAGTTTGCCGT +GCTTAACAAACTCCGAAAAAGTGTGATATTTTTTTATGCTTTTTGGAGCA +CCAAAACTACTGAATTCGAGCTTAGCAAACGGCAAATTCGGCATATTTGC +CGCACACCCCTGGTCCACTAGTTAAGCAAAACCCACCGCTGAAAACTAAT +CAATTGGTGTTTGAAACGGTGTGTGCTACTACTAGAATTTCGCTGTTCAA +AATCTCTTTATTAAACACTTCTTTGTGTCTATTCTGCCCTTTCCTCCTCC +CCGCGCAAAATCCACTTGTACCTCTAATTACGGTCAACAAGTTTGCGGGT +TTAGTTTAGTGAATGAATTGTGAAATGAATGAATGAATGAATGGATAGGT +AGGTGTGTATGTATGTGGAAAAGTGCGACACACACAACCAGCCGTCCACC +ACCGCCACTACCACCAGCAGTAGCAACAGCCATCAAATATAATCCTTGCA +TTTCATTATTTCATAGTGTCATAGATAGTAGCAGGCCCGAGGTCCGAAAG +GCCTTGACAGCGGTTTATATTCATTTCATTTGACACCCCCCCCCCCCCCC +CCCCCTCCTACTATTCTTCTTCTCTACCACATACATTCACATAGTCAGGC +CATTCATGTTTTTCACACAATTTTGTTAATAAAGCCGCTCTGGCGCCACC +TCTCAGTAGTCCTTCTTCTTCATCATCATCACTCCCTCTCCCTTACCAAT +AACCAAAAACAGTCATTGATGCGTATCGGAATTATAATCGCGCATTTATT +GTAGGACACATGACTTGCCACGAGCCGTCCACTTGGCCCAACGAATCACT +TGGTGAGTCTCTTTACAGTGAATCTTGAAATTTGTGTTGTTTTGTTGTGA +AATATTGTTAATCGTTTTTTTATTAGTATCTCCAATTAGGCCAAAACTAT +AATCGTGAAAGAATAGTTTCTGCACATGGTGCATCGACCTGATATATCTC +ACTTTTTTTGGGCTTCATCAAAAACTTGTTAGCTAATTATAGTTAAGCAT +CACATCTATTGATATGTTCAATTTGAACAGAATATGGTGCATTGCATTGT +ATTGCAACTGAAACAATTTTATTGGCGCATAACATTCAACTATGTAGTTT +ATGTACATCGATCTTAATTACCGTATTTCCTCTATTAGTATTGCACCCGA +CTAATTAACTTTGAAACGTTATATCTCGGTTCATATTGAAGATATCAATA +TATAATTAACTATGAAATAATAGCAAAAGAACTAACAAATATTTTGTTAG +TTGACCATTTTTGAATAGGACAAACGATTACGGAGATATAAGCTGTCAAA +AGTGGACAATGGGGTGCAATACTAATTGTGTAAATACCTTATATCTCGGT +TAGCTTTGGTTTTAACAAAAATTTTAAACTGACAAAATATAAGTCATCTA +AATGTCTATAGTTTTGTAGTTAACAATTTTTTGATATCTTTAAAATGAAC +TAGCGATTTTCGACATGGTGCATCAACCTCAGTTACCTAGTCTAACTTTG +CTGGCTTATTTCTTAGTTTTAGTATTAACCGTTCATTTTAATATACTTTT +ATAGATAGTTAACAATTTTTTGATACCTTCAAACTGAACCGGAGCGATTT +TAGACATGGAGCTTTGATCCTATCTTGCCTTAATTTTCAAGCTTATCTTT +TTGTTGTAAAAAAAATTTAGACATGGTGCATTGACCTGAACTACCTGATA +TATCCTACTTGATATATCTTCAATTTTAGCAAGTTTTGGAAAAAAAAAAT +TTTAATGAAATCGATTTTTTTTTTCAATTTTCAACCTTCCGGCCAAAATT +TTCAATTGAGTTTTGACCTTTTTTTTTAACCCGGCAAAAATCTAAAAACT +CCCAAGAACAATCTCCCACAAAAAACTAAAAACTTGTGAATCTAGATTAG +TCAAAAATTTGCACCTTCTTCCCATGGGATGGCTCAATCGAACCCAGTTG +ATGAATCGGCCTGTGGGCCGCGAGCAGTCGCCGCTCTAATTTGGAGCATT +TGTATATATATAGCGAAGAATTTCACGTGACCAATGAAACCAATAGAAAT +CCAATCATATTTTTGTTTTGTCTCTAAATCATCTCTTCCCTCTCTCTCTC +TTGCCCCTCCTTAACCAATCAGAGACGCACACACCGCACCGCCCGTCCGT +CATCGTCATCGAGTTCCGCAATTAGTCGTCTATTCTCTCCGTTTTTGATT +GGAGATGGAGCGAAAATGAAAGAGAAAGAACGAGAGAGAGAGAGAGAGAT +TAGCTCTTAGATTCATTCAACTAATCTTGAAATAACACACACACACACAT +ACACAAATGAATTATCTTCATTTCAAATCATGGAAATCAGCAAATTCGCT +AGAAATTTCATGGAAGGGGAAGCTTGAATTAGGAGCACTACTTGATACCG +AGTTGGAATTGTAGTCTTTTAATATTTGAAGAAATATCACAATTTTTCAT +TTTAAACTTCTAAAAATATGCAAGTTACTTGATGCATCATGCCTCTTTAG +ATAACGTTTTTTTTAGGCTTAGGCTTAGGTTTAGGCTTAGACTTAAGCTT +AGGCTTAGGCTTAGGCTTAGGCTTAGGCTTAGACTTAGGCTTAAGCTTAT +TCTTGAGCTTAGGCTTAAGCTTAGGCTTAAGCTTAGGCTTCGGCTTGGGC +TTAGGCTTAGGCTTAGGCTTAGGCTTAAGCTTAGGATTAGGCTTAGGCTT +AGGCTTAGACTTCTAGATACTTTCTCAAACCACCAAATTACTGTATATTC +TCTATCATAGATACTACTTCCATTTGGCAGCTTATAACTCAAGTCTTTTG +TTAGAGATATCACTAGCTTTAATTACAACATTATAGGTTAATAAATACAC +CATATTTTGTTAGTTTAAATTTTTTGATTAACCTAACGAGAACCGAAATA +TGAGTAGTCAAAGATTATCGATGCACCATGGTACTACACTTTACTTTGCC +GGCTCATAACTCGGTTTATTTTCAGGATATCAAAAAGGTTTTTACTACAA +ACCTATAGAGAAACATATAATAAAAATATTACTATTTTGCAAAATTTTGG +TAAAACTAATAAGAATTGAGATATAGGCCGTTGAAGTTGCATGATGCAGT +TCAAAGCCTACGGTTTTAGACTTATAGCTTTAAAAGGAGGTACCGTATTT +CCTCTATTAGTATTGCACCCATTGTTCAACTGTGACATCTTATATCTCAG +TTACTGTTTGTTCTAATCAGAAATTGTCAACTAACAAAATATTTCTTAGT +TCTTTTTCTATCATTTCTTAGTTGACCATATATTGATACCTTTAAAATAA +ACCGAGATAAAACGTTTCAAAGTTAAGTAGTCGGGTACAATACTGATGGA +CGAAATACGGTATTGAATATTTTGATCTACGTAACTATTTGATCTAAAAT +CTCGATATCATTTTAATTTCTGATCCATAGCTTTGCGTTCAATTATCCTG +CCTAAAAAATCTCTAAAAATAACGTCTACGAGAGCGGGTGAAACAATAGG +TGGTTAGATGTAAGTTGATACCCCTGAAGGGCATCCGGGATCCCCGCGCA +AAAACAGTACAAACATGAGATGTACAATCCCCCATTTTTTTGTGGTCGCT +CTAAGTTGAAATCGATGCAAAGACATTGTCAATATAGCCGTGACGCGACG +GGCGGGTGGGCTGGCGCGCTCGATGAATCAAGATCGTTTTGGGAAGAGAG +GGACTGAAAATATTAAAACAACATTTGCATTTTGTAATTGTTTGAATCAT +CATCATCATCATCATCATCAATCATATCATAGAGGTGGCGAAACTTTTCC +TGCTGGGAATGTGTCTCCTTTTTAGTACAGTCAATAAATGTGTCACTTTT +GAACGGGGGAAAAGCTTTTCTGCTTTTCTTCGCTCTCCACCTCCTTCCCT +CCTCGCTCATAAATTTCCATTTTTCTCTTTACAAACATTGATTGATTTCC +TTATTCTATTGACTTTCTGATATTAAATTGATCATCTACTAAAAGGTATA +TATATATATAAGGTATATCAACTCTTGGAGCCCATATCTTTAATGCTCAT +CAAACTCCCAGTTAGGACTGGGAGTGAAGTACTGGGTGGTGGGATAAGAA +AGTTAGGATGTGACGGGTTTCATGCTCATCTCGAGCTGCCAATCTTGCAC +ATTAAGCAATTGGCTCATTGGCATGCTCTTGTCCTCTGGGCCTGCCGCGG +AGCCATCTCCCGTTTGATATCTGCTCCCGGGGGACGTTCCCAACTTGGCC +GGAGAGAGGCGCCGCGAGCAGCACAAGCTCAACCAAAACTTTTCTAATGT +AATGGGCCGGAATTAGGGGAAGAACAAACGAAGGAGAGGGTGGGGTGGAT +GAGGAAGAGAAAAGAGCACCACCACCAACTGATTTGATGGTTGGAGAGGA +GCTCGTTTTGTTTTCTTGTCGTCGTAAGAAGAAGAAGAGAAGCGCGCTAG +TTAGTGGTTAAACGAATCAAGACCCGAATGTGATAGATGTGCCGCCAATT +TAGCCAGTAGGATTTTTGCTGATTTTGCACACATTCATTTTTCGCTTGCC +TAGACATTACATCCCATCTTATTCCGCTTCATTCATTGTCGTGATTTTAA +GATTTGGGGGACCTAGGAGCCTCTACAGTATTATTTAAATTTCACTTTTG +TTTGGATTTTGAAAAGAGATGCGTCATACATATTCATTTTAAGGCACCTA +TGTATACAGTTCAAAATTTTGGAACATTCCTGGAATAGCGATCTTAAAGC +GGGAAATATAATGACATTATCTGACAATTTTTTCGAACACCTAAAAAACT +TGAATAAAGCCAATTGAATCGTATCCCTAATGGTTTGCAAAGTTGGGCCA +TGCTCTGAATAGCTTAGAGTTCCATCCTGACCTGGAGCTCGCCAGAAGCT +GAACGCACTGAACTTCCAGTCAAGCCTCTTTTGAATAAGTCTAGTTGCAG +ACTAGAAGCCTTAACTACCTGATGAGATTTTCACCCTTCTCTCATTAGTC +TATTTCATTAAGCATGAACTTACACGAGAATTCCAATTACATTACCATGT +AACATTACTTAAGATCCCATTTCCACTTAATTTGTGAAAATCGATACGGT +TTTATAAGAAGTGTTTTGTCCTTTTGCCTATAGCCTAGAGCAAAAATACC +CAAATTATTTGGCAGATCATGTCTCCGACAATATTCTGATCGATTAAGAA +ACTTTTGCAAATCTGCTCGGTTTTTTAGTCTACATTCGCCCCCAGATAAC +TGTTCTCGGCAAGTTGCCGATTTGCCGATTTGCCGGAAATTTTTCTTTTC +GCCAACTTACTGATTTGCCGGAAATGTTTAAGGGATTTTTTTGAAGACGG +AAAATTTTTTCATTAGATATGTTCATAGAATTAGCTTGCATTACAAAATA +GGTGTATGAACATATTCAAAGGATGCGTACAATTTTGCCGATTGAAATTG +AAATTCTGAAATTTCCAAAAATAAATGTGCAAAACCACAATTTGCCGTTT +TCCGGCCAATTCGGCAAATCGGCAATTTTCTGGGTTGCAAATTTGCCGGA +AATTTTCAATTCCCTTTATTTGCCGGGTTGCAAATTTGCCAGAAATTTTC +AATTCCGCAAATTTGCCGTTTTTCCGGCCAATTCGGAAAATCGGCAATTT +TCCGGGTTGCAAATTTGCCGGAAATTTTCAATTCCCTTTATTTGCCGGGT +TGCAAATTTGCCAGAAATTTTCAATTCCGGCAATTTGTCAGTTTGCCATA +AATTTTCAATTCCGGCAATTTGTCGATTTACCGGAAAAAATCGTTTGCAC +CCACCCTTGATGTGAACGCTAGCACTACCTCCTAGTATTAAGGCTCCAGC +TAATTTCTATATCATGGCTCCCAACTATACGTTCCTCCCTCCTCCCCCTT +CCCAATTTCGAATGGGCGCCAATTATTGCTCAATTCCCATCAGATTGGGG +GGGGGGGGGGGGGGGGCATTCGTACAGTGTCAACACGAATAATAATTATG +AGCCCTCTTCTATGCCCAAAGCGCGGCGTCTTCTTCTTCACCCCTCTAGG +AAGTTCTCATAATTAGCATTTTGTAAGACTCGGTGTCCCCCTTTCAAGTA +TCTCTGGATGATTCCCCCCTCTCGCACACACTCTTCCCATTTTTTTTTCA +CAATAATCATAATCATCAAGTTGGACACCAAAAAAGCCATAAATTCGATT +CCGGTCGAATCGAGAGAATTGGAAGAGAGAGAGAGAGAGAGAGAGAAAGA +GGAAATGAGACAGAGGGGTGAGAGATGGAAAACGAACAAGTGTGATGGTC +GTCCCCCCCCCCCCCCCCCACGGGGCCGCTCCTCATTCCTATATTTATTT +ACAGCTCTCTCTCTCTTTTTCTCTTCAATTTCCATCTCTCTCTCCTCATC +TACAGTAATCGGGGAGGGGCTAGTGATAAGCCTCTCCCCGCCCCCCCCCC +CCCGGCGGTTAGGTGTCAGAAATTAATCATAGAGGCCACGCCTCTAATGT +TTTCGGAGCATCATCCTTAATTCTTTAATTCATTAACCTTAATTCATTAG +TCTTACACTGAATTTCATAACTAAACTTGTTGAAAAAACTTCTCAAAAAA +AAAAGTTTTGGCGGCTTAAGAAATGGCCTAAAATTAGTTCGACTTTTCAA +GCGGCTGGAAACTAACTTTTTTTGAAATCCCCCCTAATTATGGGTCTACA +ACGTAAATAAAAAAATTTGGTGACCAAATTTATTTAGGCCAAATCTGGTG +TTCAAATTTTTTAGGCCAAATCTGGTGACTAAATTTTTTAGGGCCCAATA +TGGTGAAAAAATTTTTTAAGGCCAAATCTGGTAACCACAATTTTTTAAGG +CCAAACTTTTTAAAGACCAAATTTTTAGAGCCAAATCTGGTGACCAAATG +TTTTTAGGGCCGAATCTAATGACCAAATTTTTTTAAGGCCAGACCTTTTA +AAGCCCTAATTTTTTAGGGCCAAATCTGGTGACCAAATTTTTTAGGCCAA +GTCTTGTGATCAATTTTTTAGGCCAAATCTGATGACCAAATTTTTTAGGC +CAAATCTAATGACCAAATTTATTTAGGGGCCAAATCTGGTGACCAAATGT +TTTTAGGGCCAAATCTGGTGACCAAAATTTTTTAAGGCCAAATCTAGTTA +CCAAATTTTTTAAGGCCAAATCTGGACACCGAATTTTTTAGGCCAAGTCT +TGTGATCAAATTTTTTTAAAAATTTTTTTCAAATCTGGTGACCAATGTTT +TTTTAGGGCCAAATTTGGTGGCAAAATTTTTAAGGCCAAACTTTTAGGAC +AAATCTGGTGACCAAATTTTTAAGGCCAGAATCCACAACTTTTTTTTGAG +AAATTTTGAAGAAGTTTCTAATTCACCTAATTCATTACTCTTTTTGAATT +TAATCTTCGATATTCCAGATTTCAAAACGATGGAGGATGCGGCGTACGCG +TGTGCTGGCTGCGAATTCACCACAAGTGAGTTTTTTTTGTTGTTTCCTTA +TCAGCATCAGCTCTATGCCTTCTCCCCACCCCACCCCGCTCCTCCTGTAA +CCTTCAATTGCCATTCATTTCACACAGTAATAGTACCACACAACACCCTT +CCATGCCTTCAATTTGACTCATTAATAGCCCTTTTCACCATGTCTTTTTT +CCCCCTCTTTCTCTCTAATACTCAACCTTTACCTACCTACCCGCAATTTA +ATTGGCAACTAATTCGGATACATTCGGACGGCTCAAACGATGCGCGTCCG +TCGTCGGGTGCCCGAGACTGGGACCGGTTTTCAGAATGTCAGTGTATGTG +TGTGTGTGTCTACCGGCTGGCAGGCAGCCACACCACTGCGATTCGTTAAT +TTATTGTGAGATGATGACTGTACATTATTTTGAGTGCTGCTGGTGCTGGT +GGTGTGCATCATATAATTATAGCCTAGTTGATAGAGATATATCGACACAC +ACACACATACACATTTACTTTCAATTGCTTCTACCCAATCTTTTTTCTTC +CATTCTCCAATTCCTCTCCTTGCTCCCATTTCGCCCTTTGATATTCACCG +CGTTTCGCGTTTCGCACTAATTTCGCGCCCGGACCGGTGTGCTCGGCGCG +GCACGTCTTTCATCTTTTTGCCTCAATTTCATTATGATAATAATAATCAT +AATAATTATGCGAGACACGGCAAAGACGCGCTCAAGAAACTGATAAGTGT +GTATAGGTCGGGTCCTTTTGAGAGAGAGAGAGAGCGAGGTGTGATAAGCG +CGTCTAATGAGCATGGGCAATCATAACATTCCTATCAGCATATCAGCATT +AAAACATTTTTTTCAGAAGACGTGTCGGACTTTGAAGAGCACGCAAAAGG +ACACGAAGAGGAGGCGGGAGCCTCTTCACAGAAGGCGTGTGCGCTGTGCC +TTGAGCCCACCGACGACCTCGAAAAGCACCTTGTCGAGCAGCATCGCATC +GCCGAGAGCGCCATCGAAAAGTTCCTGCTTACTGAGAGAACAGCCAAGTG +AGTGTTTTTTTTTGTCTTCAACTCAAATATCTAGTAGTAAGTCTTATACT +TGGCTTATATTTCAGCGGTTTCAAAATATTTTTGATAGCTTTAAAAACCA +TAGAATAACAATTAATTTGACAACAATTTTGTCGTTTGAATTTTTTGACA +AAAATTTTGTCGTTTGAATTTTTAAAATATGATCAAAGACAACCGAGATA +TAAACGGTCAAAGTCCAGTGAGAGGGGCCATACTAATAGGGATTATACGG +TAGGTAACGAAATTTTGATAAGACTTATAAGGACAAAGATAATGGAGCTA +GAAAGTTTAAACTAGTCCAATTTGAACAATAAAAATATATATAACGTACT +TTTTAGTATAAATATTTTAAAAGTAGAGTAATCTGAGATACAGTAAATTT +TTAACAATTTCTAGTCGATGCACCATGTGCAAAAACTAGTCCAGTCCTAA +AATTAAATAGCACGTACTTTTTAGTATAGATATTTCAAAAGTTAAGCCAT +CTGATATACAGTGAATTTTACCAATTCCTAGTCGATGCACCATGTGCCCA +CTTAACTTTCACGGCTCACTTCCCGGCTAATTTCAAACATTTCAAAATAT +TTTCAACTATTCAACTATAGAGGGGTTTTTAATAAACATTTTCTCAGTTG +ACGACTTTTTTATAGAATCAAAGACTACCTAGATATAGCTAGTTAAAGTC +GAGATGCAAGATTTTTCGGAAAAATCACGTGGTGTTTTCGGTTTGATCTA +CGTAGATCAACGAAAAATGCGGGAGAAGAGACGCAGAGTTATCAACTGAT +TTCGTATGGTTAAGAACGTGCTGACGATGTCACATATTTTTGAACAAAAA +ATTCCCGCATTTTTTGTAGATCAAACCGTAATGGGGCAGCCTCGCACCAC +GTGAAAAATTAGTTTTTGAGGCTTTTCTAGTCTAGAACTAAAGTTTTTTT +TTTGATTGGCCTTGTTTTTTCTAGTCTTAAACACCAGGTAGATCAAAACA +AATTTTTTTTCAGAGTTTCGATTTTTATGAATTTAAAACTTTCAAATTGT +CGCACTTCCTGTCCCTTTCAACCCCAAAAACGTTACGATTTTGTGCTATC +ATAATCATTAAACCATGCTTGCTTGTGTCAAGTTGCACAGGGTGCGCCGG +GGGGGGAATTGGCATTACTGTAAATTTCCTGCGTCTCCATCCTTGCCCCC +AGTGTCCCCATCGGCAATTAGAGAGTACGATCCGATTTTGCATATTTTAT +TCACGTCGCCTCTTGTTTACTCGCTCTAAATTTCAATCCGTCGCCAACCC +CCCCCCCCTGCCTGCCTCTTCCATTCATCATGAGTATTAGTGTATTGATT +AATTTTCGAATTCACGAATGAATTCATTGCTGGCGCCCTGCTACTAGTAA +TCAGTGAGGTCATAGCGTTGTCCTTTCGATAGGGCTAATTAAATGTTTCT +CTAGGAGCGGGAGGATAGATTTGAAATCAGGTGGGCGTCGGTTTGATCTA +CGTAGATCTACGAAAATCGCGGGAATTTAGACGCAGACTTCTCAACTGAT +TTTGCATGGTTAAAAACGTGCTGACGTCATATTTTTAGGGGAAAATATCC +CGCACTTTTTGTAGATCAAACCGTAATGGGACAGCCTGACACCATGTGCT +CAGTTACAATTGGAGGGTTTTGTCGGAAAAAAATCAATTTTTTAAACTGA +CAACACATTTTGCTCATTCTCCAAAACTGAGCCAAATGTGTTGTCAAACT +TTTCTTGAAATTTTTTTGAATCGAAATTATGTTGAGGTGAATTTTCAAAT +TTCAAAAAATGCCCCATTTCTATCAATTTGTCTTCACCTATGTTTTCGAA +TAAGGGCGAGGCGAGAGGCAGGCGGAGGTCGCCTTAAGATCATAAGATAG +CCTTATGTGATGACGAAAAATGCCAAAAAATGTATTTTTATATAGTTTCC +CCGTGTGTAGAAAAATGTAAAAAGAGCATGCATTTTGTGCATTTTTTGAC +ATTTTTCTGCATTTTTTTTTGACATTTTTTTTTCATTTTTCCACACAGAT +GAATAGCGGAAAAACGGAAAAAAATACATTTTTGCATTTTTCATGATCAC +ATGATCAACCCCATAAGGTTTTTTAAGGCATAATATTGATATTTTTTATT +AGTCTACTTTGCATAATGCCTACTATTGAAGGCAAATCAAATCGACATCA +CTTTTTGCTCATTTTCAAAACTGAGAGGCACGGCTTCTATGTTGACTACT +AAACCAGTAATAACACTTATAAAATGTTTGGAAAACACTCATACACATTG +CCACGTCATTTGGATGGAAGGGACCCCATTTGTTGAATCATAATTGATTG +TTAAACTATCATCACTCTCCCCCCGCCCTCCTCATTGGACCCCACGGCTC +CAAACTGTCTCCAATTTGCTCCCCGTCCTCTTCTTATCACCTTGACGCGT +AATTGAATTTTTGCGGATTTCTTCCTCCCCACCGCTTCCTTTGCTCCTTG +GGGGAAAAGTATGGAGAGTGTTTATGTGTGTGATTGAATTGAAGAAGGTG +GCTGACTCATTCTTTCATTTTCCTCGCTTTCTTTGAAAGAACAACTTGAC +AGTTTCCCCCCCCCCCCCCCATCTTATAATAATAATTACTTGCAGAGAAG +CGTCGTGTTCATCGTCGTCGGAGCCGAGCTCAGAATTCGCGCATCGCTGC +TCGAGGTGCTCGATGGCGTTCCGAAGCGAGTCGCAGCTGCAGACGCATTC +CCTTCAGCACGTGTTCAACACGTTCCACAAGTGCCCCACGTGTGGCGATT +CGTTTGATGAGAATACTATTGTGGTGAGTGAATTCACAACACTTTTGGCT +CACAGTCACGCTTGATCTACGTGTTTTTAGACAATTTTGAGTCTACACGT +GGTGTCAAAGTGTCTCATTTCGGCTTGATCTGCGTTGATCTACAGAAAAA +TGCGGGAGAAGAGTTTTGGGCAAAAAATTCCCGCATTTTTTGTAGATCAA +ACCGTAATGGGACAGCCTGGCACCACGTGCTCAGTTAAAGTAAGAGGGTT +TTGTCACTAGATTTATTTTTTGTAAACTGACAACACATTTTGCTCATTCT +CCAAAACTGAGCTAAAAGGGTTGTCAAACTTTTTTTGAAATTTTTTTAAA +CGAAATTAGTTTTGCTAGTTTTCCTAAAAGGAGCAAAAAGTGTTGTCCAA +TTTTTATAAGAAGGTTTTTGTCGCCTAATCGATTTTTGTAAACTGACAAC +CCTTTTCGCTCTTTTTTCAAAATTAATTTTTTTCTTTTGGCATTAATCCC +ATTTTTTGTAAATTAACAAAAAAATTTCAAAAAATCTTCAAGTATTTCTA +CAGGGTGGCCTAGATTCTCTATAGGGTGGCCTACATTTTTACACTGGTTG +TCTAGATTCTTAAACAGGGTGGCCTCGATTCTGTACAGGGTGGCCTAGAT +TTTCTACACGGTGGTCTAGATTTTCACTGGTGGCCTAGATTCTCACACTA +GGTGGCCTAGATTTTTCCACTAATAGCCTAGATTCTTTACAGGGTGTCCT +AGATTTTCACACTGGTGTCCTAGATTCTACACAGGGTGACCTAGATTTTT +TACACTGGTGGCCTAGATTCTCTACAGGGTGGCCTAAATTCCTTATAGGA +TGACCTAGATTCTTAAACAGGATGACCTAGATCTTGACACTAGTGGCCTT +GATTTTTTACAGGGTGGCCTAGATTTTCTACAATGGTCTAGATTTTTTGC +AGGGTGGCTTGGATTCTTAAACAAGGTGGCCTAGATTTTTCACAGGGTGG +CCTAGATTTTATACAGGGTGGTCTAGATTTTTACACTGGTGGCCTAGATT +CTTTACAGGTTGGCCTAGATTTTCTATAGGATGGCCTAGATTCTTAAACA +GGGTGGCCTAGATTCTTTACAGGGTAGCCTAGATTCTTCACAGGGTAGCC +TAGATTTTTACACTGGTGGCCTAGATTTTCTAAAGGGTGGTCTAGATTTT +TGCACTGGTGGCCTAGATTCTTAAACAGGCTGGCCTAAATTCCTTAGGGG +ATGCCCTAAATTCTTAAACAGGATGACCTAGATTTTATACAGGATGGCCT +AGAACTACTTTTTGTAAATCGACAGCACTTTTTGCTCGTTTTCCAAATCG +TTTTTTTTTCAGACCCATATGTTGGAGCACACCAAAGAAGAATGCGAAAT +GTGCTCTGAAACATTTGCCACAAAAGAGGCATTCCTCTCCCACCTGAACT +CAGCCCGACACCTACAACAGGCAAAGAAGCAGCTGGAAAACTCACTGGTC +GACTTAAACTCTCAGGTGAGCCGCCGCCGTGCCTCCTGCCGCCTGGCTAC +CGTAATCACCGTACCCATTATTTAATTGATTTGCTTTTAGCCACGCCGCT +GCTGCTCGGAGCGCAGAGGTGACAGAAAAAGCCGACAAAAAACAACATTA +AAATTATTACACTTTTTTATGATTGAATGCGAGAGAGATGTATGTGTGTG +GAGAGATGGAGAGGCGCATGAAATGGTGTTCGGGTTCCATAGCAAGCTCA +TTGAGCACAATGATTTTTTTTTAAATATATTTTATTGGAAATGACAGAAG +CTGAAGCTTGAAAGGAACGTCCAGTTTTAAATTAAAGTATTGATTTAGCA +CGTAGTTTCAGCATGTCCCATCACGGTTTGATCTACAAAAAATGCGGGAA +TTTTCTTCCCAAAAAATTTGACGTCAGAACGTTCTTAACCATGCGAAATA +AATTGAGAACTCTGCGTCTCAACTCCCGCATTTTTTGTAGATCTACGTAG +ATCAAACCGAAATGGGACACTTTGACACCATGTGATATTTAAAGGGTCTA +GAAAGAACTTAAAATAGCCTAGCCAAGAAATGGGCGGAGCTTTGGTAGGA +ATTTTCATAAGTCGAGGACTCCGCCCATTTCTTGGCCAATTTGGGTTTTT +GGCCTTCAATTTTTAGTGTTCACTAATTTCCAATAAGTTTAGGATTGAAA +AAGTTTTTGAGGTGAAAATTGATCCTAGCATAGGCTCCGCCCATTTCTTG +GTTTTTTTTTTGTTTTTTTTTCTTTTAAACTAAAATTCCACTGAACTTGT +CTAATTTCAGTTTCCAAAAATTTAACGAAAAAATTCGAAATGCCAAGAAA +GGGGCGGAGCCTAAGCGAAGCCTATTTTTCGATGAAATTTGGCCAAGTTG +CGATGTTTTTGAATTTCATATTTTTGAATCAAGTTTTGAAATAAAAAGTA +ATATAAAATTGGAAAATAGGCTCCGCCCATTTATTGGCTTTGTTGGATTT +TTTACTGCATAGATCACATTTTTGCATCCGAAAATTTATCGGAAAGGAAT +TTTTTTTCCCAATTTTTTTCCGTAAACTGTATCATCAAATTCTTTTGAGA +TTCAAAATATCCAACATAAGCACGGGGTTCTGGCCTTCCTCATTGAATTT +TTCGCGCTCCATTGACAATCGCCTGCCGGACAACGCGTGGGAAAGTCGTG +TACTCCACGCGGACAAATACATTCAGTTTTACGCGCCGTAAATCTACCCC +AGATATGGCCGAGCCAAAATGGCCTAGTTCGGCAAACTCTTTCATTTCAA +TTTATGAGGGAAGCCAGAACTCCGTACATAGGCGCAATAAAAGGTGAAAT +AGGCTCCGCCCATATCTTGGATCGGTTCCAATAATGTATCCAAATTGACA +TGTGTTAGTTACACTTGTTCCTAATCCAAAATTCTATCCGAATTTCAATT +TCCCAAAGTCAAAAAGTCAACAAGTTCTGTTCTTATATGTGTAAGGCGCG +CGCGAGCGCGATCGTTTGTCTCTAGTATTTGCTCATCTCTCTCTCTCTCA +ATTACCGTACCCATTATCATTCCGCCCATGGATGATGATGATGATGAAAA +TGAGCGGTGGGCCCCCTCTTCCCCTGCCTCTTTTCGCGCATTCATCATGT +TTGTACAAAAGGCGGCGGTTTGAGAAAAGAAGACAGTGAGAGGGAGGGAG +AGAGAGAGGTGATGAAGGTAGTAAACGTGTGTCGACAAACACATATAGAG +AACGATTCGTGTGAAATAGATGAGGGCAAATAGGACGAATTTATTTAAGA +GAAGAATAAGATGCTTTGGCCCAGATGAGGGGGGGGGGGGGGTATCATGA +AGGTGTGATGACGAACCATATTCCTTCAATGTTTGTTGCTCGCTTAACCG +CCGTCGCCGCAATTTAAATTGTTTCGACTGGGTGATCAGACAAATAAGAA +GACGTAGACGGTTTTTCTTGGGGGGGACGTTCAGCTTTGATTCCTTTCAA +ATAATCGATGCGGCCTAGCTTTCTGATCTCCAGAAACCGCGGGCCTTCTT +TGCTAAATTTTAAGCGATTTTACTTCCTCCCCCCCCCACTTTGATCTACT +TTAACAGCTTATATCTCGGTTGTCTTTAGCTTCATCAAAAAGTTATCAAC +TAACAAAGTGCGTGCCAAATATACTTCTACAATTCGGTAGTTAGTATTTT +TTGGATAAAAGTTAAGACAACCGAGATATAAGCTGTTGAAGTAAATTTCT +AGTTTGACTTACTCCCCCAATTTTGATCTACTTTTACAGCTTATATCTCG +GTTGTTTTTGGTAACAGCAAAAAGTTGCCAACTAACATATTACGTGCCAA +ATATTTTTCTAAAATTTGGTAGTTGAAAATTTTTGAATAAAAGTTAAGAC +AACCGAGATATAAGCTGTTGAAGTAGATTTCTAGTTTGACTTACTCCCCA +AATTTCGATCTACTTTGACAGCTTATATCTCGGTTATTTTTGGCAATATT +AAAAATTTGTCAACTAACAAATTACGACCCAAATATTTATCTACAATTTG +GTAGTTGAACATTTATGTTAAAAGTTAATACAGCCGAGATATAAGCTGTT +GAAGTAAAGCAGTGGTGGTGCTTAGCTCGACCTATATTTTTGAATTGCAT +AACAGTTATAACTAACTTATTTTATGTGAAACCCTATTCTAGCTAGTTGA +CTTACAAAATCTCCAGAAACTTTTGCCTGCCTACCACCTTTAGCAGCATA +AGCGCCTATAGGCACACCTACTGCCTACACCTATGCCACCTACTGTACAC +CTACTGCCCATACGCCTACTGCCTTTTGCCTACTTTCTACATAACTTTGA +ACTGCCCGTTTCTAACCAATAATCTTTTACAGGACGTCGAAAAGCAGCGT +ATTTATGTGTGCAACGTCTGCAAACAATCCTATCCACAAGCGGCTAATCT +CGACGTGCACATGAGGTCAATGACACATCAGAGCCGGATGAGCCGGCTGT +CCGAACTTGTGGCAACCGGGGAGCTTAATGGGGAGAAGGCCGTGTTTGAG +CAACCAGGAATACCGGCACCGACGATAAACAGCTTCATTGAGACGGTAGG +TGAGGGGTTTGAGCAGGCATAATCCTGAAAATCATCTGTTTGGTTTCTGT +GAAAAACTTTTGTGCGGAAAATAGTTTATTTATAGTTCAATTTGAAAAAA +ACTGGTTTCCGATTTTCAATTTTCAATTTTCAATGTTCGATTCTCGATTA +ATAAAATTTCCAATTTCCAATTTCCAGACAACCAACCAATCCTCACTGAA +CGACCTGATGTCACTGCTCACACGAAGCGAGTCGGATGAGATTCGAGAAG +AAGTAAACGGCCTTCAAGTCATGACACAGATCAAAGTCTACGGTGAATCC +AAGATCACTAGCCTAGTCCCAGAGTTGGCCGGGAAAATCGATAACATCGC +GCTCTTCGATGACTCCCGTGCGGCAGAGGTGTCGAAGATCGATTGCTCGG +CTTGTGGGCAGCAGATCTCAGGGATCCTTGCTTTGAACCTCCATTATGAA +GAGTCCCACTCATCGAAGATCCCGAGTGACGTGTTAAGAAAGTTCGGAGA +GCGGTTACTTGCCGCATTAGAGGACGGGTTGAGCAGAGAGAATTCCGTGA +AGAACGGATCGCAAAGCCCTCTGAGCAATGACGATGAGCCCATGGAGAAG +AAGATGCGGCTGGAGAATATGCTTCCTGAAATGGACAAGAACGCGGCAGC +GTCGCAATTCGCAATGTTCCAACAAATGATGAACTGCTTCCCGTTCATGG +CACCACCAGGCACGTCTAGTGGCAACTTTGGCTTCTCGCCAGAAATGATC +AATCAGCTCATGAATCCTGCGGCGGCGGCGGCGGCGGCGACTGCAGCAGC +AGCAGCCCACGCTGCCAACAACTCGCCGGCGAAGAGAGCAAGAACACGGA +TCACTGATGATCAGCTCAAAGTTTTACGGTAAGTCGTCTTGTGTGTGATT +ACTGTAAGCTACGGCGAACAGGAGAGACCCGAGGGGGGCGGTGGAAAATG +AATTGCAAACAATAGGTGGGAAATGGTCGGCGCCGTGATCAAAATGAATG +AGAAATGAGAATGAAGAACAAACATTGTGTGTGAGTGTGTGTGTGTGAGA +CGAGACGAAAATCAATCAATTTCTGGAAAAAACAACACATATATTTTCCC +GGCGAACTTTCTGTTTGAGGGACCGTACGGAACAGGACCCCCCTGAAAAA +AAAAATCCGGAAAATCCTAAGCCTAAATAGCGAACGCTCGCCACTGACGC +CAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCCAGCCCAAGCCTAA +ACAGGAACCCCCTGAAAAATCAAAAAATCCGGAAAATCCTAAGCCTAAAT +AGCGAACGCTCGCCACTGACGCCAAGCCTAAGTCTAAGCCTAAGCCTAAG +CCTAAGCCCAGCCCAAGCCTAAACAGGAACCCCCTGAAAAATCAAAAAAT +CCGGAAAATCCTAAGCCTAAATAGCGAACGCTCGCCACTGACGCCAAGCC +TAAGCCTAAGCCTAAGCCTTGGCCTAAGCCCAGCCCAAACCTAAGCCCAA +GCCTAAGCCTTTCACCTTCCTAATTTTCAGGCAGGCCCTAAAAACCGCGC +CTGCCTACCATGGAAGCCCTAATCTGTGCGCTTTAGATTCTGAACCCTTA +AATATGTTGCACGGCCGGGCAAAGGGCACATCAGTGTAAACGCGCTCTAC +TGATAATTCGAGTTTAGCCAGGTTTGGGCGCGTTTCAAGGAAAAAAACTT +TGGCTCAAAAAATTGTGAATTTATTTTCGAACATTTTTATATGCATCACA +AAAATGTTAGACCACCCGTTTTTGAGAAAAACGCGCCCAAACGTCCAGGT +ATACGGTAGACAAATTGCGTACAGGTACCACTGGGGGGTCGTGTTTGGGC +TTTAGTTTAGCTAAGGGAATCTGTAGCGGCCCAACGGCCTAACTGCAAGC +CTCAGCTTATTCGCCATAGGCTTGTCTGCCGTATTTCAAGCCGATTCCAA +CAAAAAACTTCCAGCCAATACTTCAACATCAACAACTCGCCGTCAGAAGC +GCAAATCAAGGAGATGTCACAAAAAGCGAGCCTTCCGGAGAAAGTCATCA +AACACTGGTTCCGCAACACACTTTTCAAGGTTTGTTTATTTATTTTACAA +AACTATTCATATTGTTATTAGGCTCGGAAATGAGCGAGGTGAGAACATGA +GTGTGGTAATTAGTCATCGGATGAATACCCACACAAGAGGGAGAGCAAAC +AAGAGAGCAATTGAGACGAGGGAGGGAGAGAGGGAGAAAATAAGAAAATG +TTAATGTCAGTTGGGTGCCAGGCGCTCGGCCAGGACCACAGGCCGGGAAC +CATTTAGTTTTGATTACGATTTCCGTCGTGACTCATGATGGGAATTGATA +TTTGTGCCTGTGGTGATAGAATAGTTAGAGCAACTATCAGGAAGGGGACA +AGTCGCAGTGCGAGACTATTAGAACCTGCAAGGTTTATTCTGATAGATTT +GGGACTAATAAGGACTAATTTGGTAGAGACTAATTGGCTCTCTTGATATA +TACCAGCTTAATAATTTCTACAAAAAAAACTGTAAGAACGCTTCGAGATT +CGAGCTTCGGGAAAGCTTAAAGGATGGGTACCGAAAAATTTTTTTTCCCT +GATTCCGAATATCGATGTGGAAAAATTCAAAAAAAATTCCCTGATTTTAT +ATTTGAGCTTGAAATCACGATTTTCATTTGTGCCCACCTGGTGTCAGAAT +GTCTCATTTTGGATTGATCTACGTTGATCTACAAAAAATGCGGGAGAAGA +GACGCAGAGTTCTCAACTGATTTTGCATGGTTAAGAACGTGCTGACGTCA +CACTTTTTTGGGCAAAAGCAAAAAATTCCCGCATTTTTTGTAGATCAGAC +TGTAATGAGACAGCCAGGCACCATGTGTGTGCCCCGGTTCAATTTTCAAT +TTTTTAAACCAGTTTCTTTTTTTTTAGTCGATAGGTTTTTTTCTGAAAAA +TATTTTTTTTGCCAAAAATGAATGTAACTGGCTAAAATAAACTAAAAATA +AAACGATGCAAGCGCGCTCAAATGCGAATTTATTTGGGCGCGAATTTGAA +AAAAGTGATGCGGGCACAAATGAAAATCGGCGATTTTAAGCCTAAATATA +AAATCAGGGAAATTTTTTTGAATTTTTTCACATTGATATTCGTAATCAGG +GGAGAATTTAAAGCCAATTAAAAATATTTTCCAGATTTCGGTGCCCCACC +CTTAATGAGATAAAAGAGCAAAAAAGGTGTTTTGTAACTTTTTAAGTTTT +TTCTTTTTCAGGAACGCCAACGCGACAAGGATTCCCCGTACAACTTCAGC +ATCCCTCCCCAAATGGGAATCGACTTGGACATCTACGAAAAGACCGGCGA +GACAAAAGTACTGTCGCTTAGCAATGAAGCACCAAAGTCTGAGTTGAGCT +CTGCGCGCGCCACACCGACAATTCCGACTCCGATACCGCTCATCGTTGAA +GAGAAGAAACCGGAGCCAAAGAGCCAGACACCATCGTCTTCTTCCTCTCA +GCTCAACCTGCAGGCTATGTTATCTCAGATGCAGGGAAGTTTTTTCGACG +CGTCAAACTTCATGTCAGCATCAGTGAATCCGATGACACCGAGCACTCCT +TCCTGCAACACGTCGTCCAGTGGACGACGAGCCAATCGCACGAGATTCAC +AGATTTCCAGCTGAGAACTCTACAGCAATTTTTCGACAAGCAAGCCTACC +CGAAGGATGATGATCTTGAAGCGCTGAGCAAGAAGCTTCAGCTGAGTCCA +CGTGTGATTGTCGTCTGGTTCCAGAATGCACGGCAGAAGGCCAGAAAGAT +CTATGAGAATCAGCCGAATCACGAGAGTTCCGATCGATTTGTGAGAACGC +CGGGATCGAACTTTCAGTGCAAAAGGTTGGTTTTAGTGTTGGAAATTAAC +ATTTAAATTTAAATTTTCCTAAATTCCAGGTGCAGCCAAGTATTCCAACG +CTACTATGAACTCATCCAACATCAACAGAAAAAGTGCTACAAAGACGATG +TAGCAGCCCTGGCAAGTGACAACAAGAGTGTCGAAGAATCACTGACGGAA +GAAGAGAAATCCCAGCTTCTGGCTCAACAACAGGTCGCCCAACTAGCCAG +CACTCTGGAGCTCCCAAAGTTCCAGCCGGCAGAGCTTTTGAAAATGATCG +GAGCTAATTCGGTGACTCCATCCTCGTCGGCTGCAAGTCAGAAGTCTAGC +AACGACGTTCTGCTGAAGATGTGTGAATCGATTGTTGGTGGGAGCACACC +TAGTACATCATCGTTCCACAAACTTTGTATATTCTGCGCTCAAGACTTCA +AGGATCGGAGTGCGATGAGTGAGCACATGGCTCAGAAGCATCCCCAGCAT +ATGCTTCTTCCAAACTTCGATCTCGACATGATGCCAGACGCTGGTGGTGC +AGAGCTTCTCATGGATCTTAAGGACTCTGCGTTGGATCTTTCGGGCTCTT +CAGTCGACTACCGGGATTCTATCTCAACATCTCCATCTCGATCCGAAGAT +GATGTTCTCACAGAGGCTCTGGATGATTCTGCATTTGCCGCGTTCGGACT +ACAGCTTGCAAATTCCACAAGCGGCTCGGAATGCAGATCTCCGGCGAGCA +ACAAGAGATTCCGAACTCATCTCACACCGATGCAAGTGCAAATGATGAAG +AGCGTGTTCAACGAGTACAAGACCCCATCCATGGCAGAATGTGAGCTTCT +CGGCAAGGAAGTCGGCCTTCACAAGCGTGTCGTTCAAGTCTGGTTTCAAA +ATGCGCGAGCCAAAGAGCGAAAGACGCGCGGTGCAGTTGACGAGGACTCT +CGATCCGGAGAACTTCACTGTGAAATTTGTGATAAGACGTTCGCGACGAG +GCTTTCGCTGCAAGACCATCTGTTTGCCGAGCAGCACATTGAATTTTTAA +GGAATAATCTGAAACGGGAAGGGGTCTCCGAGTTGACGACCGCTTCGGTG +ACCGAGTGCTCTCCAGAGAAAAAGTAAGAAATTTAATTTTTAATTTAATT +TTACATATATCATTACCCTATATAACCTTAAAAATTTTCCAGAGCAAAGC +TTCCGAACCCGCTGGATCTTGCCAGTTTCCCGTTCCTCAACACGTTCGAC +ATTCAAATTTACGGAACACCCATCGCCTTTCTGCAGGTGCCTGATGAGAT +CAAAAAGCAGATCACTGATGATATCACGGCTGGAAAATCGCGAACCACGT +TCTCCCAGGACGGTTTTCCGCTCGACAAGTTGAAAGAGTCGCTGCCCGAG +GATGAGAAATCAAATTTGACAGTAACCCAGAAAGATGTGAGCTTTTTTTT +TTTGGGAAAAATTTTGAACAATTTGGCAATTTCAGGTCGGATGGGCGTGC +CCGGCATGTACATTTGTCTTCCAAGAAGAAAAGAAGCTCCGTGAGCATCA +AAAAGCCATGTGCCAAAGTGATAAGGTGGGCAAGAAATTAGGAAACGGGC +TTGAAGTTTAGCTTATAGTTAGGCAAGTGGTGTCAGACTGTCTTTGATCT +ACAAAACATGCGGGAATTGGAATTTTTCCCAGAAAAATTGTGAAGTCAGC +ACGTTTTTAACCATGCAAAATCAGTTGAGATGTCTGCGTCATTTCTCCCG +CATTTTTTGTAGATCTACGTAGATCAAACCGAAATGAGGCACTTTCTGAA +TCCACGAGCTAGGCTTAAGCTTAGGCTTAAGCTTAGGCCTTTTCTCAGGC +TTAGGCTTAGGCTTATGCTCAGGCTTAGGCCTTTTCTTAGGCTTATGCTT +GGGCTTAGGCTTAGGCGTAGGCTTAGGCTTAGGCTTAGGCTTATGCTTAG +ACTTAGTCTCACTATCAGTCTTAGGCTTAGGCTTAGACTTAGGCTTAAGC +TTAGGCTTAAGCTTAGACTTAGGCTTAGGCTTAGGCTTAGGCTTAGGCTT +AGGTTTGGGCTTAGGCTTAGGCTTAACCTCAGGCTTAGGCTTAGGTTTAG +GCTCAGGCTTAAACTTAGGCTTAGGCCCAGGCTTAGGCTTAGGCTCACAC +GTTCTCACGTTCTTAACCATACAAAATCAGCTAAGAACTCTGCGTCTTTT +CTCCCGCATTTTTTGTAGATCTACGTAGATCAAACCGAAATGAGGCACTT +TCTGAATCCACGAGCTAGGCTTAAGCTTAGGCTTAAGCTTAGGCCTTTTC +TCAGGCTTAGGCTTAGGCTTATGCCCAGGCTTAGGCCTTTTCTTAGGCTT +ATGCTTGGGCTTAGGCTTAGGCGTAGGCTTAGGCTTAGGCTTAGGCTTAT +GCTTAGACTTAGTCTCACTATCAGTCTTAGGCTTAGGCTTAGACTTAGGC +TTAAGCTTAGGCTTAAGCTTAGACTTAGGCTTAGGCTTAGGCTTAGGCTT +AGGCTTAGGTTTGGGCTTAGGCTTAGGCTTAACCTCAGGCTTAGGCTTAG +GTTTAGGCTCAGGCTTAAACTTAGGCTTAGGCCCAGGCTTAGGCTTAGGC +TCACACGTTCTCACGTTCTTAACCATACAAAATCAGCTAAGAACTCTGCG +TCTTTTCTCTCGCATTTTTTGTAGATCAACGAAGATCGAGCCGAAATGAG +GCACTCTGACATCACGTGGGCTAAGACTTAGGCTTAGGCTTAGGCTTAGG +CTTAGGCTTAGGCTTAGACGTAGGCTTAGGCTAGTTATTTGTAACTTTTT +TAAATCTCCCCCGAGTCAAAAAAAAAAACAATTCAATTCCAGACGCTAAC +CCTGGTGCAAACCCACTACTCGTGCAAAAGCTGTCAAAGTGATTTCTGTC +TTCAATCCGAGTATCAATTCCATCTCTCAATGCCTCCTCATACTACTACT +ACTACCACGACGACGCCATAACAAAACCCCCCAAATAGTCACCTCATGTC +ATTTCATTTGCCGTCTTCACTCAAGGACCTATTTCCGTCTCTCTCTCTCT +CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTCTCCTCTCG +CCTTAAAAAAACCACAACTCCTTATCCCGATCTGAGCTCACTTCCTATCC +CCCAAAGTAATTTCTTTGTAATATCTATATCCACTTTTTTTTCGACACAC +TACACCACATCCCGCCGCCTATCCCCTCCCCCCCCACCGCTTTATGACAC +AAAAACTGGTTTCGCTTTTGTCTTCAATTTCACCCCAACCGCCTGCAGCT +TCTCATAATAATTAATAATTTTTCTTACCATGCACAATGATTTTGATAAA +TATATATATATATAGTCATCAGGATTGCCCCCTTTCTAGGATATGTTTTT +TTTTGTCTTCACACAATTTTCCCATTTTCTATGATAAGAATTATTTCTTT +GTCCGGTTGACACATGTAGATGTTCCCCTTCCAATTTTTAATAGATTTCT +ATTCTAGTTTTTTGCAGGCCTCACTATTCTATTGCAATAATCACTTGGAT +TTCATGTATGGAACGCAATAATAATTCAATAAAATATTGGTACTTCTTTT +TTGAAACACACTAATTCAAACTCACGCGGTTCCAGGCTGTCCCATTACGG +TTTGATCTACTAAAAATGCGGGAATGTTTACTCCCAACAAAATGTGACAT +CATCAGCACGTTTTTAACCATGCGATATCGGTTGAGTACTCTGCGTCTCT +TCTCCCGCATTTTTTGTAGATCAAGCCAAAATGAGACACTATGACACCAC +GTGTAGACTTAAAATTGACTGAAACCACCGAATTTCATATTGAAACTTCT +TGAAATCTATTCAAAAAAAAAGTTATGAAGGCTCAAAAAATGGCCTAAAA +TTTGTTAATTTAAACAAAAGACACTTAAAACGGTGTCTTTTTGAATTTTT +CCGTTTTTTTAAACATATTTTCATAAAATTTACTTATTTTTCAAAATAGA +TGTTGGAACATTTATAGGATGCGTTCAATTTTGCCATTTGAAATTGAAAT +TCGGAAATTTCAAAAAAAAAAAAAAAAAGTGCGAAACCAAAATTTTCCGA +AAATTTTCGGCAATTTGCCGGTTTGCCGGAAATTTCAATTCCAGCGATTT +GCCAATTTGCCGAATGGCCGGAAATTTCAATTCCAGCAATTTGGCGATTT +GCCGATTTGCCGGAACCTGCTAACCTACCTACTAACTTGCTAATCTTCAA +GGTTTTTAATGAGTTTTCAATAGAAAATTCGGTGTTTTCAGGCAATTTCG +AGAAAGCAATACAAACGTTTAACAAAAAAAAGACGCTTTTTCCTCTTATC +CGATTCTCAATTCTCAATTTTGCCTTATCAATTTATCCTCTCCTCACAAG +GTGACACACACACACACACACACACACACACTCGTTTCTCGACAAAAAGC +TATGAGCTAACAAGCGCCTTCTCGCGTAAGAATACATCCACTGATAAGAC +ATCTGATAAGAGTGGAACCCGTCCGCCATTGTCTCGAGAAATACACGCCT +CCGCCCGGGAGGACAGGTTATCCCACCTCGTCGCTTCACTTCATTGTTTC +AAACGATTCCATCGGCTTGCGCTTGGATTTTCTCTTATGCAACTTGCCAT +TCTTCTTTTATTGCTTAACATCATGGTTATTTATTAGGGAAATTGTTCTA +CCCTGACTTGAAATGACTGAAGACGGCCTATTTTACTTTAATTTGAAGAC +TCAGAAGACTACTATAAGCGGTCATTCTTGTTGCGAAAATTTCTGCATTT +AAAGGTGGAGTAGCGCCAGTGGGAAAATTGCTTTAAAACACGCCTATGAT +ACCACAATGACCGAATATCATGATAAAAAAATTCAAAAAAATTTTCTAAA +TTTTATATGATTTTTTGAAAATTGAAAAAATCTAAGGTTTTCACTTAATT +CATATTTGAATTACCGCCAATTGGATTTGCTCGATGGAGCGCACTTGCAC +GTTTTTAAATTTATTTATTTTATTTTTTGTTATTTTCCACCGATTTTTAA +TGTTTTCGGTGTATTTTTGCTTGAATTTTAGAGAAAAAGTCAAAATAAAT +GCAAATTTTCGATTAAAAAGCAAGCGTACAGGTAAATCAGTGAAATTAAT +CAATTCAGGTTCATTTTTACGCCTGTAAGCGTGCTTTTTAATCGAAAATT +TGCATAAAAAACATTTAAAATGGGTGGAAAATAACAAAACATAAAATAAA +TAAACTTAAAAACGTGCAAGCGCGCTCCATCGAACAAATCCAATTGGCGG +TAATTCAAATAGGAATTAGGCAAAAACTGAGATTCTTTCAATTTTCAAAA +AATCATATAAAATTTAGAAAATTTTTTTGAATTTTTTATGGTGCGTCCAT +AGAAAAACCGGAGTTCCTCGCTTTTTTTTCCTCGAAATTCAAAAAAGTAG +GCGTGGCCAACCAATCAGCTGTTGTTTCTTGTTTTCTCATTGCTCAGCTT +AAAATTTTACAGCCTCTAATTGGTTGAACACGCCCACTATTTTGAAATTG +ACCAATAACAAAGCGAGAAACTTCTTGTTTTTTCCGCAGACTATGGACGC +TTCCGCACGCGGGAAATTCCCGTTTTCCGCAGACTATGGACGCACCATTA +TCATGATATTGGGTCATTGTGGTACCATAGGCATGTTTTAAAGCAATTTC +CCCACTGGCGCTACTCCACCTTTAATGCATTCTGCGTCTATTTTATACAG +TTCTGACCATAAAAGCACACAAATTTTTGTCTCAAAGTTTAGGAATATAT +AGATTTAAGGAAGAAAGTTTTAGTAAGAAAAAATATAGTCTTCTTCATGT +TTTCTTTTTTTTTACAATATCCATTTGCCATCCGTTTTTTTTTCTGCAAC +CTTCGATAAATGTTTGCTTGGATAACTATGTAAGGTGCTTTGAACACTCG +GCATTTGGGCTTCTTGCCCAAGTTTAGCCCAAAAATATTAACTTGGATCA +GAAGTTGGGCAATACTTTGGCAAAACTTGGATTCAGGCAATATCAAAGTT +TAACCCAAGTTTCACCCAACAAACTTTGGCCTAAACTTTTTTTGTTTCGA +ACTTGCGTAGAAGTTTTTGCCCAATTTTCGCCCAACTTTTGCCCAACTTT +TGCCCAAGTTTAGCCAACTTCTGTTCCAAGTTAATATTTTTGGGCCAAAC +TTGGGCATGAAGCTAGAGCCGAATGCCGAGCTAATTTTATTTGACTCTAT +CCGAATTCTGCTAATTCTCAAAAATCCCCCAATTGCCAACCATTTCAGAA +TGCATTGGAGTAGTTGGGCGATAGCGCTCAACGTGCTCGTGCTGGCTTTG +GCCGACAGTGCTCCTGAAAGATTCCCAGAGGATCATGTGGACCTGGTACT +TCCTATGAAAAGTATCCACCATTTCACCTAAACGTTTCCTAATCATCTTG +ATTACAGTGAAATACGACAGTCATCTTCGACAAGCTGATCTTCCACCGCA +CTTCATTGGTGCCAATGAGACGAACTTGGTTCCGCTCACCTTGAGATTGG +AGACTAGGAGGAAGAGATGCTCGTGTGGATGTTCGGGATGTGATCTTTTC +CCGAATAGATCTTGTTGTTCGAGCTGTAAGTTTGCGATTCTATAAGACTT +GTCAACGTGGTGTCAGGCTGACCCATTACGGTTTGATCTATAAAAAATGC +GGGAAGTTTATGACCAGAAAAAAATGACGTCATCACATTCTTAACCATAC +GAAATCAGTTGAGAAATCTGCGTCTCCCATTTCTTCTCCCGCATTTTTTG +TAGATCTACGTAGATCAAGCCGAAATGAGACAATTGAAATTCCAGCTTGC +TGCTCCTCTCAAAAACCAATCCCACTTGCCTGCTGTCCGCCACCTCCCCC +ACCAAAACCGTGTTGCCAGCCAGCCTTCGGCCCTTGCTGCCCGGCAACCC +CAAACTGTTGCCCGAAACCCTGCTGCCGAGGTCGTCGCCCCGAATACGAA +GAGTACGAGGACGAGGAAGGCAACCCTGGAGGCGTCCCAGCACCACCAAA +CCCACCAAGAACTTGCTGTCCTCCACCAACACCTGCTGCTCCACCACCGC +CACCACCTCCACCACCACCGGCTCCGGAAGCTCCAACGCAATGCTGTGGA +TCACAGCCTTATGGAAGAACACCGTGCAGGTCCGGATGTCCGAATGGAGA +TTGTGGATGCGGAAGACCTTGCTGTTACTATCAGAACCCCACATGTTGTA +ATCAAGGGCAAAAGGCTTGCTGCCCACCTGAACAGCCTTGCTGTCCTGAG +TTGAAGCTGGATAACTGCCTCGCTTCGGTCCCACCTTGCCTTCGCGCCTG +TCCATCGTGCCCTTGCAGAAAACGTCTGATGCTTGGGAAGAGAACTAAGA +GAGACGCACCGGGGCTTCATTGCCAGCCAAGTAAGCTATAAGTTTAGATT +TTCACGTAGTGTCAGGCTGTCTCATAGTGGTTTGATCTACAAAAAATGCG +GGAATTTCTCGCCCAGGAAAATGTAACGTCAGCATCAGGGCTGGGACCAA +AAAAAAAATTTTTGGACCAAAGAAGTTTTTGAAAAACCAAAAAAACCAAA +AAAAAAACAAAAAAAAAACCAAAAAATTTTTGATATGCTTAAGTTGATTT +TTAATGGGGTTATTCAAGTAATGTTGCAAAATGTATTAAAATACATTTAT +GACGTCACAACTGTGTTAAAATACATGTTTTAATGTATTTTAATACAGAA +TAGTCTCGAGTCGACACTAGACACGGTAAACTTTTTTTTTAGATTTTTCG +TCAAAATACCAAAAAAACCAAAAAATTCCCAACAGCATGTTCTTAACCAT +GCGAAATCAGTTGAAAAGTCTGCGTCTTTTCTCCCGCATTTTTCGAAGAT +CAAACCAAAATGAGACACTTTGACACCACGTGGATTTTCAAAACGCTGAA +AATAAGTAAAATAAATAAAAAATTTTCAGTCGGACTCCTTGGTCAACAAT +CCCCACCGACTCTGATTTCAAAGCCGGTAAAGACCATAATAAAATCAAAA +TCCCGCGTTGCTGGAACCAAGACATCTCAAGTGTCCGTCACCAAAAAGCT +CATCGAACAATCCTCTGACCACGTGGAATCGCCTCCAACAGCCGGAAGAC +TCTACGACTTCCGAAGAGCCCACGTTCGAGTCAAGAGAAACATGAACTTT +GGAAATGGAGCATGCCAGCTGTGTCTGAACGGAACTCCGCTCAAGAGAAC +CAAGCGGTCTCTCGATTGTGTTCCGTGTACCTACCTACAACCACAATACT +CTGATTGGAACCCGTTCCTCGGAGATCAAACGCCACGCGGATCGCAGTCG +CCAGTTGGAACTCCACTCGCCGGGCACAGAACTAAGAGAGCTGGCGTGAG +TTTGACTCATAGAAATTAACGAAGCTAAATTTATTTTTGCAGTGCCTTCC +TCATCCACAATGTACCCTGCATGTCCGTCGCTATAAGAGAAACCTGATCG +GATCCCAATATTGTGAGCCATGCAATGGACACTACGGTAGAAAGAAGCGG +GAAGCCGAGAGAGATCAGTGCTTGAAAAGAGAGAAAAGATATGCAGATGA +ACAGTGTGATAACGATGAGTTCAGTATCAATGAGCGAAGCAAACGACAAG +CCTACAATCCAAAAGGAATTTTGGATATCGTGAAGCTCCTATCCAAGGCC +TCCTCAGGTGGCAACAATCCAGGAGGATGCATGAAGTTCCCAGCCTGTGT +TCTGGCTCAGAAGAAGAGAAGAAAGAGAAATGCAGATCGGCTCGACACGT +ACTACAAAGCTGTGGAGGAGCACAAGAAGCTGGTGGAAGAGTACGAGATG +GCGATGGAGGAGCACAAGAGAGTCAAGCGGCAGTTCTTCGCTCCGGATAA +TGCTGCATCCTGTGTTCCGTGTCCGGCATGGGTGACACTTGCCTTGGCTA +GCAGAAAGAAGAGAGAAGTCGAGAAGGTGGAGAAGCATATGACGATGAGC +GAAGCTATCGCGGATATCAGAGCAAAGAAGGGGTATAAGGAAGGATTTGA +TGATGATGATGAGGTGAGGACTAGACCTGAAATTTTAGATCCTGTAAGAA +CTTTTTGAAAATTCCAAAAAAAAAACCCCCTAATTGAATCACGCGCGCAC +GCGCCACTGAGAAGGATACTGTATTCGCGGCGAGACCACCTGCACATCTA +ACTCCCAAAAGTGACGAATTTGGCCTAAAATGGACTTTCTTCATGGGATT +TCCACAGTTTTCACCATTTTTTTGACACAGTTCATGACTTTTTACACTCA +AAAAATTATTGGCGTGGTCATTTCACAATGATTTCAACAATTTACTGGAT +TTTACGCGTGTACTTCATCGTGGCACACCAAAAATTGATCTGGTTCATGT +GGTGTCAGAGTGTCCCATTTTGGTTTGATCTACGTAGATCTACAAAAAAT +GCGGGAGTTGAGAGACGCAGAGATCTCAACTGGCGTCACATCAATGCGGA +TTTTAAAATTTTCATTTCAGGACGACGAATCCTCTGAGGAAACCATCGAG +ACCCGCAGAAAGCAACGCCGCTCCTGCCAACAAAGTGACGATTGCCTGAA +CAACGTCGAGTACGCAGTCTTCCAAAAAGTCTATGCAGACAAGAGAACCA +AACGAGAAGCCGTGTTCCGTCGTAAGAAGTGCTCGAGGTGTGGAGTCTCT +GGGCTCACGCCACATCGTGTCAAGAGAAACTTCGGGCAGCCGAATATCAA +CGTCTCGGAGCAGAATTGCATGGCATTCCCACAGTGTCGGCATAGAGTGA +AGAGAAACTTTTTGGGAGAAGACTGTAACATCTGTACACAGGATACTGGT +CTGAAGCGGAGGAAGAGAGACTTCGGAACAGCGGTAGGTGTTGGTTTAAT +GAGCTTCCTTATCTTAAAGTTTTCAGCAATGCTACCCATGCCCAGGAACA +CGTTCATAACTTGAAGCGACTCCCTCCGATTCTCACATATCACATAAATA +CCACCTCGTAATAATAATTCAACATGACTAATAAAACAAATAAGTACATA +CATACATTTATATTAGCTTTTAGCACCCGTAGCAATTTGGAGCAAGAAAA +TATGTGTAAAGAAATTGGAGATGTAGTAGATTTGGTCGTTATAGTGATCG +CAGATCTTTCAGCTCTTTGAGCCGGAATATTGACTGGCTTGGAGCCAGGA +GATGAACCTCGCGGGGGAATGAGGCAAAGTAGGGGTGAAGCATTGCACTG +GCTGCGGAGACACGGCTTTCCGGGCGGAGCTGTAATTTTGAGGGTTACAA +GATAGGTGTAGCTCGATGTCGATTCATTTAGACTAGCATTGCAGCCAGGG +CTTAAGCTTTCGGCTTGAGCTTGCACTCAAAGATTGCTGCTCAATATAGC +TCGCGAAGACTGATTTGTCAAAGATTAGACTAGTAGGCCTGGACTGACTT +AAAGGTGGAGTAGCGCCAGTGAAAATTTTGTCAAAATACATACATAATGA +TCCGAAAAAAAAACCAAATTTCATAATAAAACAATCCAAAAAATTAGATT +TTTCACAATTTCAGGTCAAATTTTTGGCAAACTGCTAAAATTTTGAAAAA +TGAGCAATTGAGGAAATCTAGAGCAATGTCGCATGTTCCGACCCCTACAA +TATTTTAATACAAATAATTAAAACACAATTACAGTATAAAAATGTAGGAA +AAAAAATTTTTTTTTTGTTGGTCGACTTCCAAAATTATGAGTGGTAAAAT +TACAGTAAATAAAAAATTTTCAAAATTTTTTTGAAACGTTTTATTATGAT +ATTCGGTCTTTTCGGGACTAAAGGAGTGGTTTTTACAAGTCTACTTACCT +GAAGAAGCATCCCCAGAAGTTCCTGACCAGTCTTCAGAATCTTCGTGAAC +ATCGGGTTCACCGCGATGAACGACAACTCCCGATACCTGGGGAACAGTTC +AGGGGTGTAGCCTGGTAATGTCTTTACCTGAAACAAACATCTTTATCTCT +AGATTTTAGATTCCCTCACCTCCGGCCACTTTTTCTCGTCTGGAGTACCC +CGAATGCTGAAGATCATATCCAACTGGTCCTTGGTGCCGGGGTAGTGAGA +GTCCTTGGATCCCGGGAACAAAGCGGCGCCCGTGCAAATTTCAGCGAATA +TGCAACCGACTCCCCTGCAAAGTTAGTAGATATAGTTGGTACCTTTTATA +AAATAATATCCTCCTACCACATATCCAGGGAAGTTGAATAGTCGGTACTT +CCCATGAGAACATCAGGCGGGCGGTACCATAAAGTGACCACCTCGTGAGA +ATATGTCCTACTCGGCACAGATTTCGCCCTGGCTAGACCAAAGTCTGCGA +GTTTTAAAACACCGTCTTCGTCGAGAAGCAAGTTTTGTGGTTTTAAATCT +CTGAAAATCAGTTTTTATCAAGAGTTATGGCCGCAACGGCGCCTCCGCCG +ACCCCAGCGGTCGCCGCGCCGGCCTCCGCGGAACCCCGAAAATGTCCGCC +GCTCCAAACAACCACTTTTTTGCACTACGTTGCGCACACACCAGGCTACT +CATTTCACGCCAAGCTGCGGAACACCGAACGTGTCCGCCGCTCCAAATAA +CTCCCTTTCGCAATACGTTGAGCACACACCAAGCTGCGGAACTCCCAACG +TGTCGGCCGCTCCGAACAACCACTTCTACGCACTTCATTGCGCACACACC +AGGTTACTCATTTCACGCCAAGCTGCGGAACCCTGAACGTGTCCGCCGCT +CCAAACAACTCCCTTTCGCAATACGTTGAGCACACACCAAGCTGCGGAAC +CCCCAACGTGTCGGCCGCTCCGAACAACCACTTCTACGCACTTCATTGCG +CACACACCAGGCTACTCATTTCACGCCAAGCTGCGGAACCCCGAACGTGT +CGGCCGCTCCAAATGACCACCTTTCGCGCTTCAACGGCGTCGGCGTGAGG +CCCGAATTTCGCGCCTCACTCTGCTGGGAGCCCTATCAACACTAGGGAGC +AGTTTGAAAACTAACCTATGAAGAATCTTCTTCCTATGACAAAAATCGAG +TCCGCGGAGAAGTTGAAAGAGGAGAAGCTTGATGTCAATGCTATCCAACC +CATAGACGTTCTGCTCCAGGTACTTGCTCAAATCCATTTTCATGTACTCG +AACACAAAAGTTAGCTGGTGGTGTTGATAGAAGATGTCGTGCAAAGAGAC +GATATTCGCATGACGGAGGTTTCTGAGAAGCGAGGCTTCACGGATAGCGG +TGAATGGGAGACCTTCTTGAAATTGAAGTTTGATCTCTTTCAAGGCGACT +ATGGATCCGTCAAGTCTGAAAATATAATTTAGTTTGGTAATATCAGCTGT +TAAAATATCTAACTTCGATTCGCACTTATACACCGTTGCATAAGATCCTT +CCCCCAGCTTGTCAATTCGTTTGTACAGATCATTCACATCCTGCGGTGTC +ACTTCCTCCTTCGCAGGAAGCGTTATCGTATTTGGATCGTAGTGTGCTGA +TCGTGGTCGACGTCTTCGAAGATGTGTGAAGTCGGCCACAGTGTTGCTAG +ATGGTGGTGGTGGCATTGATGGAGAGTTCTTGTTTAGGGGCACGGTTGAC +ATGGTTTCAGATGGATTGTTGGAGCGGGAACGTGATTGGCGGCTGAAATG +GTATTACTAGGGTTTGATTCGGAAAATTTTCTTAGAAAAACAGTTTGGCG +GGAAGTTTAAATTTTCTGATTAAAAATGTTGGCGTAAGTGGTGTCGAAGT +GCCCCATTTTGGTTTGATCTACAAAAAATGCGGGAGTTGAGACAAAGACT +TTTCAACTGATTTTGCAGGATTAAGCTGACGTCACATTTTCCTGGGGGAA +AAATCCCCGCATTTTTTGTAGATCAAGCCGCAATGAGACAGCCTGACACC +ACGTGTTGACGGGATATTTAAATTTTCTGAGAAAAACATTTTGGCGGGAA +GTTCAAATTTTCTGAGAAAAACATTTTGGCGGGAAATTGAAATTTTCTGA +CAAAAAAATTTTGGCGGGAAATTGAAATTTTCTGACAAAAAAATTTTGGC +GGGAAATTGAAATTTTCTGACCAAAAAATTTTGGCGGGAATTCAAATTTT +CTGGGAATTAACTTTGGGGAGAAGTTCAAATTTTCTGTAAAAATTTTGGC +GGGAAATTGAAATTTTCTGACAAAAATATTTTGGCGGGAAAATCAAATTT +TCTGAGAAAAAAAAATTTTGGCGGGAAATTGAAATTATCTGACAAAAATA +TTTTGGCGGGAAAATCAAATTTTCTGAGAAAAAAAAATTTTGGCGGGAAA +TTCAAATTTTTTTTTTTTGAAAAGAAAATTCTACGGACCGGAAACGGCCC +AACTACGGCTCAAGAGCCGTCTCGGTCGGTAAATGTGTTTTTTGCTCTAA +ATAATGCATTTAACGACGTAAAAATGCTTAAATTAGCCAACTGGTATCAT +AGGTATTAAAAAAATTCGTTTTCTTAAAATCCATTTTTTCCTCTTAATGG +CCATTTTTTTACATTCCCCGTAGTTTGCCCGTAATTGGTCCGTCCCGCTT +TTCATATCCGTAGTTCACCCGTTAATGGTCCGTTCCCGGTCCAAGATCCG +TAAACGGACCGTACCGGCTTTGCCTGTGGTCAGATATAACTAGTAAGTCA +AGTGGTGTCAGGCTGCCCCATTATGGTTTGATCTACTAAAAATGCGGGAA +TTTTTCCCCCAGAAAAACGTGACGTCAGCACACTCTTAACCATGCGATAC +CAGTTGAAAAGTCTGCGTCTCTTCTCCCGCATTTCTCGGAGATCAAACCA +AAATGAGGCACTTTGACACCACGTGGTAAGTTATAACAAACATAACAAGG +TGTCGAAACTACTGTAATTATAGTCTTACTTCAATATACAACCTAATAAG +AATCTCCACCACTTACCTCAAAAAGCTGAAAATATTCTTATTATGATGTT +CTGGTGTGCTTCCACTTCCGGACCCCGATGATGCCCCATTCACATGATTG +GAGTGCCATGATTGTGTCATTTCATTTGTTCCGTTTTTCGAGATCGGAGA +TTTGGTGGAGCCTCCTGAAAAAACAGAAATAAATGTGGAATTATATGGGG +GCTCATATGTTTTCGGAACTAACCTTTTTGGGAGAAGACTCTGGAGAGCA +TTTTTGTGTAAACTGACTAACTTGTGCCACCCCCCGCACCCCATAGAATA +AATTGGCTAAAATTTCGAAAAAAAAAACTCGCCACCGCCGTTATTCTTGT +ATTTCTTCTCCTTATTCCGACTCCGACGCAAAGTGAAAATTGACGAGGAC +GGCTGGAATAATGTTTTGTGTTTGTGTCTTGTGGAAGAGATGCAGAATCG +CCGGAAGTTTAGAGGGGGTGGCGTGACTTACTGACCTTCCGGGTGCTCGG +CGAGCCGTCCACGTCCTGAATTCGTTGCGGCGACATTGTGGTGATCTGGA +ATATGTGGAGCGTAATCGAAATATTTAGGCTTAGGCTTAGGCTTAGACTT +AGGCTTAGGCTTAGTCTTCGGCTTAGGCTTAGGCTTAGGCTTAGGCTTAG +GCTTAGGCTTAGGTTTAGGCTTAGGCTTAGGCTTAGGCTTGGGACTGGGC +TTAGGCTTGAGCTTTGGCCTAAGCTTAGGCTTAGGCTTACGCTCAGGCGT +AGGATTAGGCTCTGGCTTTGGCTTTGGCTTAGGCTTAGACTTAGGCCTAG +GTTCACGCTTAGGCCTAGGCTTACAAGAAATATCCTCATTTACCGACCGA +CTGTGGCCTAGGATTTCAAAAAATGACCCTTTTTGAAAAATCGAAAAATC +GAAATATCGACGAATTTTCGTTTTTGAGGCGTTTTTTTAATTTCAATTTT +TATAATTTTTTTCGGTTTTTCGATTTTTCTTGAAAATACCAAACTCACCC +TATGCAAGTTCTCCGACGACTTCGAACTCCTAACAGCGGTGAGCTGTGGA +TGATGTATCATAGACAGTGAGCACGATGCTCTCATAGGCCTCTCGGCCTC +CTCCAGCCCAAACCATACTCCAATATGCGAGGTTATTTTTCCCCACATTT +GATTGAAAGATGGTATCTGCAAGTGAAATTTTTGGGTGGGGAAAAAGAAC +GTGAACGAATAATTTGGAGCAGCGGGGGGGGGGGTGGAAAAATGAAGAGC +TGCTCGGAGGAGGGAGCCGTACTACGAAATGAGAAGAGGAGAAGCCGGTG +TGACGGCGGGGCGTTAATGGGTTACTAAAGCCTCCACATTCCCATTTTCA +GCCGTTTCGAAACAAAGAAAATAGAAGAAAAAAAAGACAGATGAAAAATG +ACTTGGGTGGGTTCGGTGAAAAACAGGAAGCAGGAAGAGTGAGGAAATTG +GATGGTGGAAGAGTTTTGGCATTTCTAGGTTACCGGGAATCTTTAGAGAC +ACCTGGGCTGTCCCATTACAGTTTGATCTACAAAAAATGCGGGAATTTTT +CGCCCAAAAAATTTTCAACAAATTTAGATATTTTTTACATTTTTTCCCCA +ATTTTTTCAGCCATATTTCAGCCATGACTGTCCTTTTTTTCGGGCAAAAA +AAAATTTTCTCTGAAAATGTTCGAAACTACTAAATTATGCAAGAAGACAA +TTTTTAAGGTTCGGAGATCAATTTTGAGTCCTCTAGCTTCAAAATTATCC +ATTTTAGAAGAGTTTTAAAATTGTAATTTTTTACAAAAATTGCTCAATTT +TGCCACTTTTTAATAGTTTTCTAAACCTAGATTTTCTGAATTCTGCATAT +ATGAATTACCCGTTTTCAACAAATTTAGACAATTTTTTTCATTGTTTCCA +AAATTTTTTTCAGCCATTTTTCAGCCATTACTGTCCTTTTTTTGGGCAAA +AAAAATAATTTTTTGAAATTACATTACACACCTTCCATGTTTTCTTCGTA +GATTTAAGGTCCATGTCCACTGCTTGGTGGAAGAGTTTTCCGAGTTTTTA +GGTCACCGGAGAATTTGAGTTGGAAGAGTTTTCGCATTACTCCCCAACTG +TGATAGAACTTCAAAAATGAATATGCAGGGACATCACTCAAATTTGACAT +GTCAGTTTAAAGGAACACGCTGATTTTCCGAGTGGGTCTCGCCACGATCC +AGGTGCTAAATTTTCACAGTTTTTAGTATGTACCTAGTGGCTTATTTCTA +AACAACACGCGCATAACATCGGAGTGTCGTTGCATAGGCCACTCTAAAAC +ATAAACAAATGTGTGAAGAAAAATTAAACACAACTAGCACGGATTTCTGA +CGTCCCTCAGAAGTTGAAATGGAAGAGTTTTTGCCGAACTAGGCCAGGCC +ATATTCGGGGTAGATTTACGGCGCGTCGCGGCTCGATTTTAGTTGTAAAA +CTAAATGTATTTGTCCGTGTGGAGTACACGACTTTCCCAAGCGTTGTCCG +GCAGGCGATTGTCAATGGAGCGCGAAAATTCAATGAGGAAGGCCAGAACC +CCGTGGGATTTTGAAATTTTTTTCAGATATGACAAAAAATGACAATGCCA +AATTTAAAATGCATTAATAGCGGACAGAGGAGAGAATAAGTAGGGAAAAA +AGAAGAAAAAAAAAGACGGGCGGCGCTTCTCTCATAAAATAGTAATTGGT +CATTCTAAGTGTGCCTATTGTTCCTTATTTTTCGCTTTTTCTTGGCTCAT +TTTAGCTCAAAAACCAAATGTCGAAGAGTTTCTAGAGAACTAGGCCACGA +GAGGGAAAAACTAGGTCACTGGAATTTCTACGCTAAAAATTTGGCCCAGC +ATATTTACCTACGTGGCCGTAAAAGAGAAAGTTCGGCCACTAACTTTTTC +GGGCTATCAAAAAAGGTTTACCAAAACTTTATAAAAAAGAAACCACTTGT +GGAAAATGGCCGTGCATACTAAAGTTCGGCCACAAACTTTTTTAAAACTT +TTTTGCTCAAATTGAAGTACAGGACCACTTCGATGGGCGGTTTTCACTAC +TTGGCCGTGTAAGAGAAAATTCGGCCACCAACTTTTATTCAAGGCCACAC +CTCCAAATCCTTCAAAGCTTCAAAAATTTTCTACGTGGCCGTGTACGAAA +AAATTCGGCCATCATCTTTTTTTTGGGTCACGTCGCTAAATTCTTCAGAG +CTTCAGAGATTTTCTACGTGGCCGCGGGAGAGAAAATTCGGCCACCAAAT +TATTTTTTAAGGCCAAACCTCCAAATCCTTCAGAGCTCATATTTTCTACG +TGGCCGTGTACGAGAAAACTCGGCCACCAAATTAATTTTGAAGGCCCCAC +CTCCAATTTCTTCAGAGATCATATTTTCTACGTGGCGTGGCCGTGTACGA +GAAAATTCGGCCACCAAATTCTTTTTTAAGGCCAAACCTCCAAATCCTTC +AGAGCTCCTATTCCCTTCGTGGCCGTAGGAGAGAAAGTTCGGCCACCAAA +TTAATTTTTTAAGGCCACGTCGCCAAATCCGTCATATTATGAGGAAAAAA +GTAAAAAATAATACTAATAACAATTGAAGAAAAATTGAAAAATATAAAAA +TATAAGAGACTAGTAAATGAAGAGGAATGAAGAGCGAATAGGAGGCCAGA +GAGAGAGAGGGGAGGAAATTGTGCTGTTGAAGACCTTGAAGAGAGAGGCA +CAGCAATAGATAAATTGAATTACAATGGGGTGAGGAGCCGGGTCTGTCCC +CCCCCCCCCCCCCCCCCAAAAAGTGCGAACAAATGTGATGAAGCGCAGAG +AAAATCGGGAGGGGGGGGGGGGGGGGGGGCTGTGCTCCAGGTTGATTGAG +CCAAGTGTTTCGACTTTTTGCCGAACACGTTGAGCTCTCCGATGAGCCGG +GCTCACCGGAGAGCCCATGGAGCCCCATGAAGCAGAGGGTCACAAGGTTT +GAGACTTCCGGGAGATAGACTGCACAACGTACAAAGACTAAAACTTTTTT +TTTTTGCAGGTGAGGCATGAAATTTAGAGCTTTTTTGCAACAAAATCCAA +CATTTTTTTTGTAAAATAAGGTCAAATGACGAGTTTTTTCTATAATCTGG +CCGAGAAAACCTGAAAATTGATCTACCTTGATAAACAGGGCGCGCGGGTG +TAAAGCGGAGCGTCGTTGTGAAGCTGAAATATTGTTGAACGAATTCTGGA +ATTCTGGCTTCCCTCATAAATTGAAATGGAAGAGTTTTTGCCAAACTAGG +CCAGGCCATATCTGGGGTAGATTTACGGCGCGCTTTTTTTTGGGCATAAA +ATTCCCGCATTTTTGTAGATCAAACCGTACAGCCTGACATCACGTGTTTT +TGGCCCCGCTAAACAGGGCGCGGGTGTAAACATTCAAATATTATGTGAAA +AAAACGCATGAATTTGAACAATTTTGCGTAGAATTTTTGAACAAAAAAAT +ATATGAATAACTAATGCAAAACGAACAGAACTAAATTTTCTGAAATTGAA +GAGAGGGGAAAAAAATTGGGAAATTTTGGACATTTTTCCCAACGACGCAT +TGAGCCACCGGACCCAGATGAGCAAATAAACCGGGGGAGCAGGAGGAAAA +TGGAAATGACAAAAAAGGCGGAGGAGGAGAAGCTCACGTATTTAGTATCC +CATAGAAAGAGTCAATTTTCATAAACTGCGACAATTGACTACCAGGGAGC +AGTTGCGCTCTACCGACAAAATCAAGCAAGGTCCACGTAGTGCCAGTCTG +TCCCATTACGGTTTGGTCTACAAAAAAATGCGGGAAAATTTGGCTCAAAA +AAATGTGACGTCAGCACACTCTTAACCATGCGAAATCAGTTCCCGCATTT +TTTGTAGATCTACGTAGATCAAGCCGAAATGAGACACTGTGGCACCACGT +AAAGGTCCTTCTTACAGAGTGCGCTAGAGCGCGATTGCCAGTTTTCTAAA +AAAAAAATCTAACATGAAAAAATGTGCGTAAAAGCGGAGTTTCGTTGCGA +TGTAAAATTTGGAGAAAAATTGAAAACTGAGGAGGAAGAAAAAGTTAAAT +GCCTCTTCGCAAGACCGGGATTAAATAGTATTTTACTTCTTTTTTTTCCT +TCAACTTTTTGAAATTTTTGGCGGAATGGGGAAAAGGAAAAAAAAACGAA +ATCATCGATAAAAACAACACTAGGCCACCCAGAAGTAAACCTAGGCCACC +TTATAGAAATTCTAGGCCACCCTGTAAGAATTTTAGGTCATCGCGTAGAA +AAGCTAGGCCACCCTGTTGAACTGCTAGGCCACGCTGTTGTACACTTAGG +CCACTCTGAAAAAAATCTAGACCTCCCTGTAAAAAATCTAGGCCACCTTG +AAAGAATTTTAGGTCATCGTGTAGAAATTCTAGGCTACGTTTTCGAAATT +CTAAACCACTCTGTAGAAAACTTGGGTCATCTACCGAAATTCTAGGCCAC +CCTGCAGAAAACTTAGGCCATCTACCAAAATCCTAGGCCACCCTGTAGAA +AACTTAGGTAATCTACCAAAATTCTATGCCACTCTGTAGAAAACTTAGGC +TACCTCGTTAAAGTTCTAGGCCACCGTGTAGAAATCTTAGGCTACCTCGT +TAAAATTCTAGGCCACCCTGTAGAAAAATTAGGTGATCTACCAAAATTCT +ATGCCACCCAGAAGTAAACCTAGGCCACCTTGTATAAATTCTAGACCACC +CTGTAGAAAACTTGGGCCATCTACCAAAACTCTAGGCCACCCTGTAGTAA +ACTTAGGTCATCTACCAGAAAACCTAGGCTGTTCCGTTACGCCGCATGCT +AAAAAATCCAGACCGCCCTGTAGAAAATCTAGGTCACTCCCTACAAAACC +TAGGCCACCCTGTGAAAATTCTAGGCCACCTTGTGAAAATTCTAGGTCCT +TCCCTAGAAAAACTAGGCCACCCTGTTAAACTCTTAGGCCACTCTCTAGA +AAAACTAGACCACCCTGTAAAAAAACCTCGATGGCCTAGAAAAAAGCTTG +GGAAATTTTGTGGAAAAAGTTAAAAAGGAAAATCTAGGCCACCCACAAAA +AAGCTAGGCCACGTGGCAAGAAACTTCAAAAGTGACGAATGATGAGACGA +GAGGCGTATGTTTGAGGTCAAAAAGGGTGAAAAAGAAGAAAAAAAGACGA +GGCGGAATGTTTCTTTTTTCTTTTCAAACTGAGCATCTCCCCGTCTCTCG +GCCACCAATACTACTACTACTACAACTATTCATGTTTTTAGAGAGCCCCC +CCCCCCCCCCCCCCCGGCCACTTGTCAGCTTTTTTGACGGAAGATGCCAA +CACACAATCGAAGGGGAAACCATAAAAACCCGCCAACGACACTCCGTTTT +AAGGCCCGGATGCCCAGATGTATGAAAAAATGGAGAAACTGAAGGCTTCT +CCCCTCCCCCCCCCCTCCCTTAAAAAATGATGAATTACTAATGGTGCCGC +CCATGTTGTGTTTGTTGCTTTCCCCCCGTGCTCCATCATTGGGGGAACAT +GACAGCCACCTTGAGTTACATGTATACAAAGTGACAGGAGGGAAAGATAG +GGGTAAAAGTGCAAAAAGGGAGTCGCGGGTTCGAACCAGTGAGGGTTTGC +AAAATTTGGGCTGTGCGCGGCGCCTTAGACTACTGCGCCACGCGTGCGAA +CTGTAAATAGAACTGTCAGGCTAAATACGAACGTTCGGTTTTTAAACTCG +ATTGGCAAAAATGAAATGAATGAATAGACAGGAATGACTCATATTTTTTG +CATAAAGGGGCCTGGGTCTGGGAACTAGGAACTAAACTAAATGAAGGAAA +ATTGAGGCATCTCCCGCCAATTGAGTAGAAAAGTGATGAGAGCGGCAAAA +AGAGATAGGGGGGGGGGGGGGGACCCATTCATTTTACACTGGACACCACA +CTCCCCACTCTCTCTTTGATGACGAAGGACATGAGTACGAACTCGCGAGC +ACAGAAATACGACACGTTTTCTTCTCATTTTTTTTTTGCAAAAGGTGATG +ATGATAATCGCTTCTAAACGAGGGGAAGTGTACTAAATAATAAAATTGCG +AGTGGATATTGGATTTTTTCGTTATTTTCCGCTCTGAAAAACCTGAAAAT +CAGTCGGAAATTCGAGTTTTGGCTAACTTTTTGTAAATTTTGTTTAAAAA +ATCACTTTTCGCTGCGAAACCACCTGAAAGGATATAGTGGGCATGCGCCT +TTGAGCGCTACAGTGGAGGGAATGCAGTATCTCTTGGAAGTCAGATTTGC +CGATTGTTTTAACGCAAAACCTGAAGTATAGAAAAGAAAACATGAAAATT +TATTGAAAATATAATAAATAAATTAAGCAAATTACATATCAACTGAGAAA +ATCACCTGCTGGAGAGAAAAATTGAAAAAAAACCAGAAAATCGGCAGGAA +AGCAATAATCGAGCAAGATCCTTGGAATTTTTAGGTGCAGATATCGGTTC +AAAAGGAAAACACTATTTTAGCTTTTTTTTGTCTTAAGTTCAATGTTATA +ACACAAGAAACGATATTTCTATGGCATAATTTTTGGGTCCTAGAAAGCAG +ATTTTCACGTAGATTGGTCTGAAAATAATATTGGAGTAATTTTTATTATT +TTTCCTTGCATTATAAAATTATTTCTCTTTTATTTCTCAATTCTAAAACT +ATTTTCCCGTTCTTTTTCCCTATATCTCGCGCTTCTCCGGGATGTTGCAT +CCCATTCGACGTGAGGAGTCTCGGAGTCTCTCCGCTGCAAACGCGCTCCA +CTGGACACAGAAAATAAAAAAAATAAATTGTTCGAATTCATGCAATTTTC +TTCTAATTTTCTCCGTTTTTCGTCAATTTTTCTGCAAAAAAGACAAAATT +TACAGGTAGCAATGTATGGGGGATATCAAGGAGCATATGGGTAAGGCTAA +AAACTAGGAAAAACTAGGAAAAACCCATGGAAAACTAAAAAACTCTGAAA +TTTCAAATTTCAGAGCCTACGGGAACCAGCAGGCGGCTTCACAACCATAT +CAACAGCAAGGACAACAGAATTATTACCCGTAACTCGAAAAAAATTCAAA +AAATTCGAAAAAAATCAATTAAAAAGATCAAAATTTTCAATTTTTTCAGC +GGAGTGAACCCGTACGCGGCGAATTATGGGTACGCGGCAGCACAGCTTCC +ACCACCACCTCCACCACCGCCAGTATGCCTTAAAATTGAAGAAAATTTGA +TTAAAAAATTGAAAAAATGCAAATTTTCAGGTAGCCGATCCATACGCCGG +CCAATTTCAGACATTTCCCTCTCAAGCCACCAAAATAGCGCCGAATCCCT +ACTTTAAAAAGCCACAAAATCAGCAGCAACAGGGTATTTTCGCCGTGTTT +TCTGGCTGCAAAAAAATTAAATTATCGATTTTTTTAAGGCTACGACGCGG +CGGTCTACAATTACGCTCAGCAGAATACTCCGAAAAATTGGAAACACGGC +GGCGGCGGCCGGCAGGGGAGACAGGGATCTGGCGATAATAAACAGTACTA +TTGTGAGGTAAAAAACGTGGAAAAAATCGAGTAAAACACAGTTTTTTATT +CAAAAATCTGAGAATTTCCGTAAAAAATCCTGTTTTTTGACGTTTTTAAG +CAAAAAAATCGGGTTTACAGCACTTTTAGAGATAAAAAAGTGGAAAAAAT +CGAATTTTGGACCTGATTTTGGGCTTGAAAGCATGATTTTTATCAGAAAA +CACAGTTTTTTTTGTCAAAAATCTGAGAATTTCTATGAAAAGTCTTGTTT +TTGGATGTTTTTAAGCAAAAAAATCGGGTTTACTTCATTTTTAAGGGTAC +AAAAGTGGCGAAAAGTTAATTTCTTGTAAATTTTCACATGCAAAATATTG +AATTTATTAGGTTTTTTCCAGAAAAAGTAGTTTTTTTGCTACATTTACAG +GCTTTTAAAACTGAAAACATGTTAAATTTCGAGGAAAATCGACAAAAAAA +CCCATCTTTTGGCCAAATTTAAATTTTTGAGCAAAAAAATCGGGTTTGCA +GCACTTTTAAAGATAAAGAACTGAAAAAATTCAATTTCTTGGAGAAAAAA +GCAATTTCAACACCAAAAATAGCAAAAAATTCGGGAAAATTGTCAATTTT +TTTGAAAAAAAACTTGAAAAACCGGATTTCCAGTTGTTTTTTCATGATTT +TTTCTCAAAAATCTCATAAAAATTGGAAAAAATTCCGAATTTTTTACTGA +AAATTCGAGAAAAATTGAAATTTTTTCAATTCCGATTTAAAAAACATTTT +TCGCTAAAAAATTGAATATTTTTAGGCTTTAAAGTTCGGAAAAGATGCTG +AAAATTCGGAATTTTCTGTTTAAAGAAATTTTTTTTGTGCTGAAAAATTG +ATTATTTTTATGCTCCAAAAACTGGAATTTTTGAAAAATTCGGACAAAAA +AATTTTTTTATTAGTTTTTAAATTTTTTTAATTTTTCAACCCGCTTTTTG +CCCAAATTTAGATTTTTTATTTAAAAAATCGGGTTTACAGAACTTTTAAA +GGTAGAAAAACTGCAAAAAGTTAATTTCTTGGATATTTTCAGGCTTTAAA +GTCCAAATAAACATGTTGAAAATTGAAATGTCTTCAATTTCGATTAAAAA +CATTTTTTTCGCTAAAAAATTGAATATTTTTAGGCTTTAAAGTCCAAAAA +ACAAGCTGAAACTTGAATTTTTTTCATTTTCAATTTAAAAAAATTTTGCT +CAATAGATTTTCAGGCTCCAAAACACTGGAATTTTGGACTTAATCGAAAA +TTCGGACAAAAAAATATTTTTATTAGTTTTTAATTTTTTTAATTAAAAAA +AATCCCAATTTCCAGGTGTGCAAAATCTCATGCATTTTTAGGGTTAAAAT +TGGAAAAAATTATCAAAAATTTTCGAATAAAAATGGAATAAATCTGATTT +TTATAAATTTTTCGAAAAAAAAATGATTTGTTGGCAAAAATTAAATATTT +CAGGCTTTGGAAGTCCAAAAACCATGTAGAAAATTCGGAAAAAATCGAAA +AATTGGAAGAAAAAAATTTTTAATTTCAAAAAATTTCAAAAAAATATTTA +AAGCTGGTGTAGTCGACTTTATTTATTGCTTAAGTAGACTCTAAATTGCC +TGGAAACACCGAATTTCATAATGAAACTTCTTGAAAACTTCTCAAAAAAA +AAAGTTATGACGGCTCAAAAAATGGACTAAAATTAGTTAAAATTTGAAAT +TTGACCGACTTTTCAAGCGGCTGGAAACATTTTTTCTTTGAAATCACCGT +CAAATTTTGAGTATACTGTGCAATTATGTTGCGTTTTCAACTTCATTTAG +GTATTTTAAAGTCAAAGGGCGGCGAGATTTTTAATTTTTTGAACCAAATC +TCGCCGACCATCGACTTTAAAATATCTAAATCGAGTTCAAAACTCAAGAT +AATTACATTATATAATCAAAATTTGACGGTGATTTCAAAAAAAAGGTAGT +TTCTAGCCGCTTGAAAAGTCGGTCAAATTTCAAATTTTAACCAATTTCAG +GCCATTTTTTTAGTCGTCATAACTTTTTTTCGAGAAGTTTTCAAGAAGTT +TCATTATGAAATTCGTTGTTTTCAGACAATTTTGAGTCTGATAAAGCAAT +AAATAAATTCGACTACACCGCCTTTAAATATTTTTTTGAATTTTTTTAAA +ATTAAAATTTTTTTTTCCAATTTTTCGATTTTTTCCGAATTCTCCACGTG +GTTTTTGAACTTCCAAAGCCTGAAATATTCAATTTTTGCCAACAAACTAT +TTTTTTTTCGAAAAATTTATAAAAATCAGATTTATTCCATTTTTATTCGA +AAATTTTTGATAATTTTTTCCAATTTTAACCCTAAAAATGCATGAGATTT +TACACACCTGGAAATTTGGAATTTATTTGTAGAATTTTTGGATTTTTTAA +TTAAAAAAAAGTTTTTTCCGATTTTTTTTCCGAATTTTCAACATGGTTTT +TGAACTTCCAAAGCCTGAAAATGATTTTTTGAATAACTTTTTGATTTTTT +CGGTTATTTTTGGTTTTTTTTTTTAATTTAAAAAAATTAAAAAATTAATA +AAAATATTTTTTGTCTGATTTTTCGATTAAAGTCCTGAAAAAAAAATCTA +TTTTATAGCAAAAAATCCTAATTTTCAGCCTGTTTTTTTGCCTTGATATT +CAATTTTTACAAAAAAATTTTTTTTGGAGTTTTTTGCCTAAAAAATCGAA +AAAAAAAATCATCTTTTCTCGAATTTTTGGAAGAAAAATTAAAAATTTCA +AAAATAATTCAATTTTTTGGTGTTTTTCGGGTTTTTTACATAATTATTTT +TTAATTTAAAAAGTTTGTAAATAACCATAAAAATTTATAATTTTTTAAAT +TAAAAAATAATTATTAAAAAAAACTCGAAAAACACCAAAAAATTGAATTA +TTTTTGAAATTTTTAATTTTTCTTCCGAAAATTCGAGAAAAGATGATTTT +TTTTCGATTTTTTAGGCAAAAAACTCCAAAAAAAAATTGTTTTGTAAAAA +TTTAATATCAAGGCAAAAAACAGGCTGAAAATTCGGATTTAAAAAAATAA +TTTCTTGCTATAAAATAGATTTTTTTCAGGACTTTAATCGAAAAATCAGA +CAAAAAATATTTTTATTAGTTTTTTAATTTTTTTAAATTAAAAAAAAAAT +CAAAAATATCCGAAAAAATCGAAAAATTATTCAAAAAATCATTTTCAGGC +TTTGGAAGTTCAAAAACCATGTTGAAAATTCGGATAAATAAAAATATTTT +TTTGTCCGAATTTTCGATCAAAGTCCAAAAACTTCCAGTTTTTGGAGCCT +AAAAATAATCAACTATTGAGCAAAATTTTTTTAAATTGAAAATGAAAAAA +ATTCAAGTTTCAGCTTGTTTTTTGGACTTTAAAGCCTAAAAATATTCAAT +TTTTTAGCGAAAAAAATGTTTTTAATCGAAATTGAAGACATTTCAATTTT +CAACATGTTTATTTGGACTTTAAAGCCTGAAAATATCCAAGAAATTAACT +TTTTGCAGTTTTTCTACCTTTAAAAGTTCTGTAAACCCGATTTTTTAAAT +AAAAAATCTAAATTTGGGCAAAAAGCGGGTTGAAAAATTAAAAAAATTTA +AAAACTAATAAAAAAATTTTTTTGTCCGAATTTTTCAAAAATTCCAGTTT +TTGGAGCATAAAAATAATCAATTTTTCAGCACAAAAAAAAAATTTTTAAA +CAGAAAATTCCGAATTTTCAGCATCTTTTCCGAACTTTAAAGCCTAAAAA +TATTCAATTTTTTAGCGAAAAATGTTTTTTAAATCGGAATTGAAAAAATT +TCAATTTTTCTCGAATTTTCAGTAAAAAATTCGGAATTTTTTTCCAATTT +TTATGAGATTTTTGAGAAAAAATCATGAAAAACCAACTGGAAATCCGGTT +TTTCGAGTTTTTTTTCAAAAAAATTGACAATTTTCCCGAATTTTTCGCTA +TTTTTGGTGTTGAAATTGCTTTTTTCTCCAAGAAATTGAATTTTTTCAGT +TCTTTATCTTTAAAAGTGCTGCAAAAAACTACTTTTTCTGGAAAAAACCT +AATAAATTCAATATTTTGCTTTTTTTTTTCCTTTTTTTGTGAAAATTTAC +AAGAAATTAACTTTTCGCCACTTTTGTACCCTTAAAAGTGCAGTAAACCC +GATTTTTTTGCTTAAAAACTTCCAAAAACAGGAATTTTCGGGTTGAAAAA +TTAAAAAATTTTAAAAACTAATAAAAATATTTTTTTGTCCGAATTTTTCC +AAAATTTCAGTTTTTGGAGCCTAAAAATATTCAATTCTTTAGCGAAAATT +GTTTTTTTTTCAAAAACTTCCTACGACTACACCACCTTTAAAAAACCAAA +TTAAATTAGAGAAATTCTTCAAAAAATCCCCAAATTTCCAGGTTTGCAAA +ATCTCGTGCGCCGGCGGAATCACATACAAAGAGCATCTGGAAGGTCAACG +GCACAAGAAAAAAGAAGCTATGGCAAAACAGGGCATACCGAGCACTTCCC +TCGCTAAAAATAAGCTTTCCTATCGTTGTGACCTATGTGACGTCACTTGC +ACCGGTCAGGACACGTATTCGGCTCACGTTCGTGGCGGAAAACACTTGAA +AACTGCACAATTGCACAAAAAATTGGGAAAACCGGTGCCTGAAGACGTTC +CGACGATTATTGCTCCGGGAGCCGATGGGCCGACGGAGACGAAAGCCAAA +CCGAAATGGCATCAACAAGCTCTGCCTGGCGGGAAAATGTGCGGAATTTG +AAAAAAAAATTTTGGAAAAAAACGAGAAATTGCACATTTTTAGGCTCAAA +AATCTGAAAATTTAGCAAAAAAATTTAGAAAAATTTGGATTTTTAGAAAA +AAATTAGCGTTTTCTCGCCAAAAATGCTCAATTTTCGATAAAAATGTACA +TTTTTTTTTTTGGATTTTTAAAAAAATATTTTAGGGCTCAAAAATCTGTA +AATTCTGCAAAAAAAATTCTAAAAAATTTTGAAATTTTGAGATTAAATCT +TTCGCCAAAAAAACGAAAAATTTGAATTTTACAACTTAAAATGCTCAATT +TTCGAGGAAAATGTAAAATTTTTTTTCAATCTGAAATCTGTAATTTCTTT +TAAAAAATCGATTTTTTAAAAAATTTCTACTGTAAAATTTTGAAAAAGTT +GAACGACGTCAAAAAGAAGGTAAAAATCCGAAAAAAAGCAACAAAGAACT +AGGAATTTTAAAATTTCCAAAAATGGTCTGAAATTTTGAGAAATCAAAAA +AAACAAGTTTCTTTCAGTTTTTTTTAGAAAAAAAAATCGTATTTCAGAAT +TTAAATTTAAAGCATATTTTAAACTTTTAAACGCAAAAACATTATATTTT +TCTTTAAAAAAAAAACAATTTAAACGCATTTATTGCTTTATTAGACTCAA +AATTGTCTGAAAACACCGAATTTCATAATGAAACTTCTTGAAAAAAAAAA +GTTCTCAAAAAAACAAGTTATGATTGCTCAAAAAATGGCCTCAAATTAGC +GGAAATTTGAAATTTGACCGACTTGTCAAGCGGCTGGAAACTAGCTTTCT +TTTTTGAAATCACCGTCAAATTTTGAGTATAAAATGTAATTATCTTGCGT +TATCAACTTGATTTAGGTATTTTAAAGTCGATGGACGGCGAGACTTTTAA +AGGTGGAATACCGAAATTTAAGACTTTGCTTTTTTAGACCGAAATTTTGG +CAACTTATCGGTGCGACACTGCAAAATTGCCAAAGTTTGAGATTTTAGCT +AAAAATAGGCCGTTTTTTCCAAAAACTTTGATCGGCCATAACTTTTTTTT +GGAAAATTTTCAGAACGTCTCATTACGAAATTCGGCAGTTTTGGGCCATT +TTGGGTCTAAAAAAGCAAAGTCTTAAATTTCGGTACTCCACCTTTAAAAA +TCTCTCCGTCCATCGACTTTAAAATACCTAAATCAAGTTGATAACGCAAG +ATAATTACATTTTATACTCAAAATTTGACGGTGATTTCAAAAAAAAAAAG +TTTCCAGCCGCTTGGCAAGTCGTTGAAATTTCAAATTTCCGCTAATTTGA +GGCCATTTTTTGAGCAATCATAACTTGTTTTTTTGAGAACTTTTTTTTTC +AAGAAGTTTCATTATGAAATTCGGTGTTTTCAGACAATTTTAAGCCTAAT +AAAGCAATAAAAAATTAGAATATACCACTTGAGAAAAATTAAAGATTTTT +TTAAGTTTAAAATAAAAAAATATGTTTCTTTCCGATTTTTTGATAGTGAG +ATAAAAGTTTTGGCGGGAAATTCAAATTTTCTAGAAAAAAAATTGAAAAA +ACTCATAGTGTATAACTGCACAGAACGGCTGGTTATGAGTATAGGTGTCA +AAGTGTCTCATTTCGGTTTGATCTACAAAAAAAGCGGGAATTTTTCCCAA +AAAAAGTTACGTCAAGATGCTCTTTTTTATTAAATTTAATTAAAAAAGAG +AGCATGCTGACGTAACTTTTGAGGAAAAATTCCCGCTTTTTTTTGTAGAT +CAAGCCGAAATGAGACACTTTGACACCACCACGTTCAGACAAAATCCCCC +ACTAAATATTTGGTAAAACTAGTTCAAAACCCGACTGTAGTACATTTTTG +GCAGAAATTTGAAAATTTCAACTTAAAACCGCTCAATTTTTCCAAAATTT +CACAGTATGCATTTCAAAAATTATGGTTTTGTTTTTTTTTAATCGAAAAA +TATATTTTTAACAAAAATGGACCATTTTTAGTTGTAAAATTCAATTTTTT +GGCGCTTTCAAATTTTTAGGCAAAAAATGTGCAATTTTCTCCAAAAATTT +TCAGATTTTTTAACCCTAAAATTAAAAAAAAATCTAAAATATTAGAATTT +CCCGCTTTTTTTTTCAAATATTTCAATTTTTCCAATTAAAACACAAAAAT +TGAGCATTTCTAGTTGGCACATTCAAATTTTTAGGCGAAAAATTTGATTT +CAAAATTTCAAAATTTTTCAGAATTTTTTTTTGCTAAATGTTCAGATTTT +TGTGCGCAAAAATATTTGAAAAATCCAAAAAAAAAACTCGAAAATTGAGC +ATTTTCAGTTGTAAAATTCAACTTTTTAGGCGGAAAAATGTGCAATTTTT +CCCCAAAAAATTCAAATTTTCCAACTTTTCTCTCAAATAGCACAGAAACA +GAAAATTTGTTATACCTAATGTGGAAAAACTGAATTAAAACAGATTTTTT +GAAAAAATGCACTTTTTTTTTTGCCAAAAAATAGTTCAAACCCCGACTTT +TTGTTCCAGAGTTTCCAGGTCATCGGTATCATCGCATAAATAAATTTTGC +GGGAAAAATTCCCGCTTTTTTTGTAGATCAAACCGAAATGAGACACTTTG +ACACCCCACGTTCAGACAAAACCCCGACTTTTTTCCAGAGTCATCGGCAT +CAACACGGTAAACTTCGTCGGCGGTACGAAGCTCAACTCCACCGGACAAC +TCGAGGAGAAGAAGCGCGAAGTTGCTGCCGCCGTGAGCTCAGTCGGCCGG +AAAACCGGTGGTGCTGCTGCAACGACGACGATTGAGGTGGAAGACGAGAA +GCTCCGAGCAATGATCGCCGCCGAGGAGGTACAACCTGTCGGCGAGGAAC +ATGTCACTGAAGAACGTGATGCTACCGGAAAACTGGTGCAATTCCATTGT +AAACTGTGCGATTGCAAGTTCTCCGATCCGAATGCCAAGGAGATTCATAT +CAAAGGTCGTCGACATCGTGTCAGCTATCGGCAGAAGATTGATCCGACGT +TGGTGGTGGATGTGAAGCCATCGAACAAAAGATCACAGGAGAAGCGGAAG +AATCAGCTTCCAGCAGTTCATGGTGTGTGGATTTTTTAACAAAAAATCAA +CAACAACACAAAAAACATGTTCCAATAAAATTGGAAAAAAAAATTTAAAA +AATCCCAAATTTCCAGGTGTCTAAAAATCTCATGCATTTTTAGGGTTAAA +ATTGGAAAAAATTATCAATTTTTCGAATAAAAATGGAACAAATCTGATTT +TTATAGAAAAAATAATAATTTGTTGGCAAAAATTGAATATTTCAGGCTTT +GGAAGTTCAAAAACTATGTAGAAAATTCAGAAAAAATCGAAAAATTGGAA +GAAAAAAATTTTTAATTTGAAAAAATTCAAAAAAATTTAAATTTTTTTAA +AAATTGAATTTTTGAGTAAATAATTTTTTGCTATAAAATTCAATATTTTC +AGGCTTTCAAGTCCAAAAACCGTGTTGAAAATTCCGAAAAAATCGAAAAA +TTGGAAAAAAAATTTTAATTTAAAGGTGGACTACGCTCAGTGGGGGGAAA +TTGCTTTAAAACATGCCTATGGTACCACAATGCCCGAATAGCATAATAAA +AAAATTTTAAAAAATATTCTAGATTTTATATGATTTTTTGAAAATTGGAA +AAATCACAGTTTTTGCCTAATTCCTATTTGAATTACCGCCAATTGGATTT +GTTCGGTGGAGCGCGCTTGCATGTTTTTAAATTTATTTATTTTATTTATT +GTTATTTTCCACCGATTTTTAATGTTTTCGATGTATTTTTGTTTGAATTT +TAGAGAAAAAGTCAAAATAAATACTAATTATCGATTAAAAAGCACGCTTA +CAGGCGTAAATCAGTGAAATTAATTAACTCAGGTTCGAAATCGTTTAAAA +TCGTTACTTTTTCATTTTTACGCCTGTAAGCGTGCTTTTTAGTCGAAAAT +TTGCATTTATTTTCACTTTTTCTTTAAAATTCAAGCAAAAATACACCGAA +AACATGAAAAATCGGTGGAAAATAACAAAAAATAAAATAAATAAATTTAA +AAACGTGCAAGCGCGCTCCATCGAACAAATCCAATTGGCGGAAATTTAAA +TGGGAATTAGGCAAAAACTGAGATTTTTCCAATTTTCAAAAAATCATATA +AAATCAGAAAAATTTTTGTTTTTTTTTTAATTTTTTTAAACATGACATTC +GGTCATTGTGACCCCATAGGCATGTTTTAAAGGTGGTGTAGTCGAATTTT +TTTTATTTCTTTATTAGACTCAAAATTGTCTGAAACCCCGAATTTCATAA +TGAAACTTCTTGAAAAATTTTCAAAAAAAAGTTATGGCGGCTCGAAAAAT +GGCCTAAAATTAGTGAAAATTTGAAATTTGACCAACTTATCATTGTCGCA +TCGGCTGGAAACAATTTTTTTTTTGAAATTGTCGTTCAATTTTGGGTGTA +CAGGTCGATTATCTTGCGTTTTCAGCTTTATTAAGGTATTTAAAAGTCGA +TGGACAAATGGATCTGTCAAATTTTTTACCAAATCTTTTCGTCCATCGAC +TTTTAAATACCTAAATAAAGCTGAAAACGCAAGATAATCGACCTGTATAC +CCAAAATTGAACGACAATTTCAAAAAAAAATTGTTTCCAGCCGCCGCAAC +AATGATAAGTTGGTCAAATTTCAAATTTTCACTAATTTTAGGCCATTTTT +CGAGCCGCCATAACTTTTTTTTTTGGAAAAGTTTTCAAGAAGTTTCATTA +TGAAATTCGGTGTTTTCAGACAATTTTGAGTCTAATTAAGCAATAAAAAA +AATTCGACTACACCACCTTTAAAGCAATTTCCCCACTGGGCGCTACTCGA +CCTTTAAAGGGGGAGTAGAGTTTGTGGGTATTTTGCTTAAATAGACTAAA +ATTGGTCCAAAACCACCGAATTTCATAATGAGACTTCACAAAAAATCTCC +AAAAATTTTTTATGGCCGGTCAAAATTTCGAAAAAAAAAGATGCAACTTT +TGCTAAAATCTGAAATTTCGCACACTTTTCTTTGTCTAGCAGCCGCTGGA +TTTTAGTTTTTCTAAAATTATCACCCTCTAATCCTTCTTTTTGGTAATTT +ATCTCGCGAAAATCCGTTGATTGAGACAACTTTTAGGCCGATAGGCATCC +AAAAATGATCAATCTAGGGATGCCTATCGGCCTAAAAGTTGTCTCAATCA +ACGAATTTTCGCGAGATAAATTATTAAAATAAGGATTAAAGGGTGATAAT +TTCAGAAAAACTAAAATCCAGCTGCTGTGACAAAGAAAACTGTGCGAAAT +TTCAGATTTTAGCAAAAGTTGCATCTTTTTTTTCGAAATTTTTTATTTTG +ACCGGCCATAAAAAATTTTTGGAGATTTTTTGTGAAGTCTCATTATCAAA +AATTCGGTGGTTTTGAACCAGTTTTAGTCTATTTAAGCAAAATACCCACA +AACTCTACTCCCCCTTTAAAGGAATGAAAATAATTATTGGAACGTTTGTT +TTTTAAAATGATTTTTTGTTAAAAAATCCACACCGACGAAAAATCCACAG +TTTCAGAGCCTCCGAGCTTCATGAAAACGCCGTGGTTCGCCCCACCGGCT +CCAGAAGGCCGGGAATTCAATATAGTAGATGATAGAACTATTAACGAAAA +GTACGCCGGGCTTAATCCGGGCGTCGAGTTCATTTCCAATGTGGATCGCC +TTATTTCGGATATCAATGAATCGCTGAAGTATGTGTCGGATAAGATCGAG +CGAGACGTTCGGAAGATCCCTGAAGACGTGGTGGAGCTTCCCACCACCAC +CACCACAACGGAGCAGCCGCCGCGGACAGTGTTGGGATGCTCGAGAGTTG +GAATTATTGCGAAGGGAACGTTCATCAAAGGGGATCGGTGTGCGGAGGTG +GTTCTGACGTGTACGCCGGTGCCGACTTCGGGGCTTGTTGAGCAGATTAG +GCGGTTGTTTGGAGAGTCGACGGTACGGGCCGGCCTTTTTTTTTTGCCGG +AAATTTGGGGATTTACCGGTTTGCCGGAATGTTTTTTTTTCCGGCAAATT +GCCGGTTTTCGCCGGAAATTTGAAAAACGGCAAACTGGCAATTTGCCGGA +AATTTTCAGTTTCGGCAAACTGCCGCGATTTGCCGGATAACAATCGTTTA +TTCCGGCAAATTCGGTAAGTTGCCGGTTTGCCGATTTGCCGGTTTGTTGA +ATTTAGCGGAAATACGGCAAACGGCAAGTTGCCGGTTTCCCGACTTACCG +GAAATTTGAAAAACGGCAATTCGCCGGTTTGCCGGAAATGTGAAAAACGG +CAAATTTCAGAATTCGGCAAGTTGCCGGTTTTTGCCGGAAATTTTCATCT +TAGGAAAATTGCCGGTTTTTGCCTGAAATTTTCATTTCAGGAAAATTGCC +GGTTTGCCGGTTTGTCGAATTTTCCGGAAATGTGGAAAACGGCAAGTTGC +CGGTTTGCTGATTTGCCGGAATTTTTAATTTTCGGCAATTTACCGATTAG +CCGGAAATTTTTTAACGGGATTTTTGATAAGACGGATTTTTTTCCGGCAA +ATTCGGCAAGTTGCCGGTTTGCCGGAATTTTTCATTTTTGACAAATTGCC +GATTCGCCGAATAATAATTATGCCAGAAATTTGAAAAACGACAAGTCGCC +GGTTTGCCGATTTGCCGGAAATTTCAAAAAACCGGCAATTTGCAGAATTT +TGCCGGAAATTTTCATATTCGGCAAAGCTACCGATTTGTCGGATTTTTTA +AACCGGTTTTTTCATAAGATAGATTTTTTTTCCGGCAAATTTCCGGCAAG +TTTCCGGTTTGCCGGAAATTTCAAAACCGGCAATTTTCCGAATTCTGCCG +ATTTCTTGTTTGACAATCTCAATAATTACACAGACATCTCTAACAATTGA +GCCGGATCCCGAGTCCCCATCAAGCCTTATCGTCACAGCTAACTACTTTC +CCAATATGAAATGTCGTATTCTAATCACTTCAGCTGTAGTTAGAAAAGAC +GATGATAGTATTGTAACTGGATGTGCTGCTGATAAGGATTTGTGCATTTA +TGCGCTCGCTTCTATTCGGAATACAAAGTGGTATGATGTGAGTTTTTTTT +AAATTTTACACATATTTTAAATTACTTTATCATTGGAAAATCTAATAAAT +TAGAGCCCAGTTTACAAAAAAATCTATATTTTTCCAAAAAAAAAATTGAA +AAAAATCGATAATTTCTCAAAAAATGTTTACAAAATCGAACTTTTTCCAA +AAAACTTTGAAAAAATCGATAATTTTAAATAACTGCTGACAATTAAAAAA +AATCGAAAATTTCTCAAAAATTGAAAAAATTAATATTTTTCCAGAAAAAA +TTGAAAAAAATCGATAATTTCAAATAATAGCTGAAGATTTTTTAAAAAAA +TCGAAAATTCGAACCTTTCTCAAAAAATTTGAAAAAAATCGATTTTTTTT +CCAAACTTTTTTTCATCAAAAATTTCTCAAAAATTTGGAAAAAATTAGAA +AAAATCAATATTTTTCCGAAAAAATTTGAAAAAAAAATCGATAATTTCAA +ATAATAGTTGCAATTTTTAATTTAAAAGCGAATTTTTCAAAGATTTTTCA +AATTTTTCACGTTTTTTTCTCTGGTTTTTTTAAATTAAAAAGCGTAATTT +TTACCGAATTTATCATTAAATTACATGAATTTTTCTGAAAGAGCGAGAAA +ATTAAAATAATTCGGAAAAAAAACAATTTTTTTCCAAATTTTCCAAAAAA +TCCCACAGAAACCACCAAACTTTACTTTTTTTTTTTAACAAAAAAAAGTT +TTAAAAAATATCAATTTCCGGCTTTTTTTCTGCCAAAAACTTTGGAAAAT +GTGGGTAATTTTGGCTTTAAAAGTTTAAAAATTGAAAAAATCAGGAAAAC +TTTTTGAATTTTCAGAGTCACTGCCAATACTTGAACTCGTGCCAATCAGT +TATTCGACTGCTCCGAGATTTGCGAAATAAATATCCTGAAGTTGCGTGTC +TTGATGATTATGTAAGTTTGAGAGTTTGGAAAAATATTCGAAATTTTTTG +TGAAAAATTTGGTAAAAGTTCAAAATAATGTATAATTCTTTAATTTTTTT +GCGAAAAAATTAATTTTTTGAAAAAAATTCTCTATATTTTTTGCTAAAAA +GTTTAAAAATCTAAATAGTATGAAAAAATATTTTAGCAGAATCAACAAAA +ATTGTATAAATTCATAATTTTTTGAAAAAAATGAAATAAATTTTTTTTTG +CGAAAAAAATATGCGAAATAGGTTTTTTTAATGCAGGAAATAGTTTTATA +GCTGAAAAAATGAGAAAAAACGGAGAAAATTGAAAAATTACGTACATTTT +GCAGATTTTTTGCTCACAATTTTGTAAAAATTTCGGCAAAAATATCACCT +TATTCAAAAAAAAATTGCTAAAAAAAATTTTTATAATACAAAAAAAATAT +GAAATCTATCTATTTTTTTCAAAAAATCTACCTAAAAATCTATTAATAAT +TTTCAATTTTTTTGTGAAAAATTTTGAAAAAATTCAAAATAATGTATAAT +TCTATAATATTTGGCGAAAAAAATTAATTTTTGAACTATAATTTTTTTTT +TGAAAACTAGTTTCAAAAATCGATATTTCACCTAAAAAAAACCCTAAAAA +TAGGCGGCAAACTATTTTTCCGGCAAATCGGTGGTAATTGCCGAAATTTT +TGGCAAATTGTGGCTTTGCAATTTTTTTTTTGTTGGAAATTTCAGATTTT +CAAATTTAATCGGCAAGAAAACTGAAAAATCCCGTTTAAAAAATTCCGGC +AAATCGGCAAACCGGCAAATTGCCGAATATAATATTAGGTCTCCTAATAA +GTTCCGGGTCAAAAATCATAACCTTGTTCGCTGTGTATCGATTTTTATGA +AACTTTGGGAGTTTATGTTATCAACCATGATCTTTCAATTGACAATAGTC +ACAAAATTTTTTGACCACCCCAAGTGCCCGTACTCGGAGCCAATTTTTTC +AGGCATTTTTCTGATCTCGCTTCTTTTTATCTTTGAATTGAGGTTTGTGT +GCGGATTTTGCTTTGTTTAGAATACATCATTAGAAAACGAGAAAAGTTTG +GAAAAAAATCTGTCCAAAAAATTTTTTTTGGTTGATCGTCAAAAAAGCTT +CAAAAAGATTTTTGTCGAAAATTCTAGATTTTTCATACAAAAATGATGTA +ACCAAGTGTAAATTATTTTTATACATACAAAACATATCAATTTAGTTCGA +TACACTAAAATGATAATAAAAAATATAATTTTTTCGGATAATTTTTGAGT +TTTTTGAATATTTCTTAAGTTTCAAATTTCAAACTAAAAGGATTTGTGTG +TGTAAAAATAATTTACACTTGGTTACATCATTTTTGTATCAAAAATCTAG +AATTTTCGACAAAAATCTTTTTGAAGCTTTTTTGACGATCAACCAAAAAA +AATTTTTTGGACGGATTTTTTTCCAAACTTTTCTCGTTTTCTAATGATGT +ATTCTAAACAAAGCAAAATCCGCACACAAACCTCAATTCAAAGATAAAAA +GAAGCGAGATCAGAAAAATGCCTGAAAAAATTGGCTCCGAGTACGGGCAC +TTGGGGTGGTCAAAACATTTTGTGACTATTGTCAAATGAAAGATCATGGT +TGATAACATAGATTCCCAAAGTTTCATAAAAATCGATTTGCAGCGAACAA +AGTTATGATTTTTGACCCGGAACTTATTTGGAGACCTTATACAATTTTTC +AACATTTTCCAGAAAATGGAGCTAATCGTCTCGAACATTATCGATTCATC +TCCAATGTCACTTGGACTATCCGATGCGTTTAAGCGAATTGTCGAAGCAC +TTGCATCTGGATATTTGTATTCTGGTAGGGGGGTTAACATTTAATTTTTT +TAAAATATTGAAAAATGAGCATATAAAAAGTTTTAAAATAATTCAAATTT +TTACAAAAAAAAAATTTTTTTTTTCAATTATTTTGCGTTTTTGTATGAAA +ATTGTGTTTTGAGAACGGAAACTCTTTTTTTTTAATTAAAATTTTGAAAA +AAAATCCTGGAAAAATGCTGAATTTTTCGGGATTTTTCGGAGCACATTTC +CAAGCTCTAAAAATTGCTGAAAATTGAATTTTTCAGAATTTTTTTGAATT +TTGCACAAAAATGACTATTTTAGGAACAAAAAAAACATTTTTCAATCACC +GAAAAAATGTATTAATTTTATATTTTAATGTTAAAAATACGGTATTTAAA +TTTTTTTTAAACGTTTTTTTTACACAAAAAGTTGAAATTAGGTTGAACCC +GGATAAAATTTAGAAAAATTAAAATTTCAATTTTTTTTGCGTTAAAATAT +GTTTTTTAAGGTTGAAAAAAATATGTTTATTCAAATAAACACATTTCTTG +AAAAGTTCTTTTGATTTTTAATATTAAAAAATTTATTTTTCAAAAAAAAA +TTTATTTATTTAATTTTAAAATTTTAAAAACTTTAAATGTGGTGTAGTCG +ATTTTTTAAATTGTTCTATTAGACTCAAAATTGACTGAAAACACCGAATT +TCATAATGAAACTTCTTGAAAACTTCTCAAAAAAAAGATATGACTGCTCA +AAAATGGCCTAAAGTTAGTTAAAATTTGAAATTTGATCTACTTGTCAAGC +GGCTGGAAACTATTCTTTTTTTTGAAATCACCGTCAAATTTTGAGTATAA +AATGTAATTATCTTGCGTTATCAACTTGATTTAGGTATTTTAAAGTCGAT +GGACGGAGAGATTTTTAAAGGTGGAGTACCGAAATTTAAGACTTTGCTTT +TTTAGACCCAAAATGGCCCAAAACTACCGAATTTCGTAATGAGACGTTCT +GAAAATTTTCCAAAAAAAAGTTATGGCCGATCAAAGTGTTTGGAAAAAAC +GGCCTATTTTTAGCTAAAATCTCAAACTTTGGCAATTTTGCAGTGTCGCA +CCGATAAGTTGCCAAAATTTCGGTCTAAAAAAGCAAAGTCTTAAATTTCG +GTATTCCACCTTTAAAAGTCTCGCCGTCCATCGACTTTAAAATACCTAAA +TCAAGTTGATAACGCAAGATAATTACATTTTATACTCAAAATTTGACGGT +GATTTCAAAAAAGAAAGCTAGTTTCCAGCCGCTTGACAAGTCGGTCAAAT +TTCAAATTTCCGCTAATATGAGGCCATTTTTTGAGCAATCATAACTTGTT +TTTTTGAGAACTTTTTTTTTTCAAGAAGTTTCATTATGAAATTCGGTGTT +TTCAGACAATTTTGAGTCTAATAAAGCAATCAAAAAAATATTCGACTACA +CCACTTTTTGGCCTATTTTTTTGGCCTAAAATTGAAATTTTTCCAGCAAT +CCTAAGCGATCCGTGTGAGACGTCTCGTCCGAACGTTCTCGATGCTTTAA +CCGACGAGCAGAAGCATTCGTTGACCGCCCTGGCACAGAATTTTGTTCGG +CAAATTGCATTCAATCAGATACATGAGGTATGCGGGGATTTTTCCTGTGC +AGAAAAAATGTTTAGTAAATTAGGGAAAAAAACCTTGAGTTTTTAAAAAA +ATCTGTGGAAAATTTGAAAATTTTCGCAAAAAAAAAATTATAATAAAATT +AATTTCAAATTTGCAAAAATTTCAATTTTTCAAATAAATTTTGAATTTGC +ATTCCAAAGTCACTAAAATGGAAAAAATTGCTAAAAATTGAATTAAAAAT +ATTTCTTTCCTGAAAATTTTTTATTTTCCGAGAATTCTGAAATTTCTTTT +AAAAAAAATTAAATTCGCGAAAATTTGAAATTTTTTGGAATATTGCAAAA +AATTGCTAAAAATTGAATTTTCCTATATTTCGATTTTTTAGATTTTTTAA +AAAAGTTTTTTTTCAGCCATTTCTGGCCGAAAATTGAGAAAAAATAGTCA +GAAAATTCAAAAAATTGCTTTTTTTTTTCAATTTTCCGAAATTTTGAATA +TTGATCGTCCGAAAATTTAAAAAATAATCGCTAAAAAGTTGAAAAAAAAA +TTATTGAAAACAATTTTTTTAAAATAATTTCTAGCAGATTCCATGAAAAA +AGGCTGAAATTTACGAAACAATTTTTTTTTCAAATTCAATTCAGAAAAAA +TTGAATTTTCTCTGATTTTGGGCCGATATTTATAAGATTTTTCAGAATTT +TCCAAAAATTCTTGAGAAAAATTGAAATTTTTCTGCCGTATTCCTATGAA +AACAGCGGAAAATTGAATTTTCCAAGTTATTTTTATAGGGAAAATTATAG +TGACTCTATAGAATTCATGAAAAATTCTGACAAAAAACCAAACATTTTGG +CCCAAAATCAGAGAAATTTCACAAAAAAAAATGCTGAAAAATTTAATTTT +CAGCAATTTTTTTTTCAAATTTTTTTAAAAAATAAATTTTCGTAAATTTC +ATAATTTTCAGTTTTTTTCCATTTTTTTAAAGAAAAATTATTTTTCCAAA +AATGTGCAGAAATTTCAGAATTTTCGGAAATTAAAAAAATTTTTAGCAAA +AAAAAAAATTTTTTAATCCAATTTTTATGATTTTTTCACTTTTTCGGTGG +TATTAGGACTGCAAATTCAAAGTTTCTTGGAAAAACATAAATTTTCAGAA +AATTTAAAATTAATCTGATTATAATTCGGAGCATAAAATGTGCTTTTATC +AACAACATTTTTTTTTTCGAAAAGTCAAATTTTTCCACATTTTTAAAAAT +TCCTTTTTTTTGTATATATTCGGATTTAAATTTTTTTTTTAACGGGTTTA +AGCTATTTTCTGAGCAAAAAAATTGAATTTTTCTAAAATCACCATTTTTC +TTCCAGATTCTCGGAATCGATCGTCTTCAAGACACTATTGATCTACCAGA +GGATGCTCCGATGCTCAAAAGACCACTGGAGAGCAATGAAAATGCTGAAA +ACGCAGAAAATCTCGACGATTCGCCAGTTTCCAAAAAGGAGAAGCTCGAC +GAGGAGCCCGCCGATATTTGAGCATTTTTATTTTAAATTTGGTTTAAATT +ATTTAATTTTCCTCTAATTTTCCTCATCTCTGTGTTTTTTTCTAATGTTT +TTGGGTCCCGTAGCGAAAAAACGAATGGCTCTCTTCGCGGTGAGACCTTG +AAATTTTTATTTTTCTACTATTACCTCCCCCTGCAAACGCGCTCTATTGA +CGACAATTCGCAATGGAGCGCGATTGCATATTTTGTTACTACATTTTCCA +CACTCATGTTCGATCTTCCACTAGGGGAGGGTCTCGCAGAAGGATTTTTT +GAAAAATTTAGATTTTTTTTTGAAAAATATTCGAAACAATTTTACGTTTT +TCGAAAAAAGTCCTAATTTAGCCTAAAAAATCAAAAATTGATAGGATTTT +TGAAAAAAATTCAAAAAATCAAAAAAAATTGCAAAAATTTTTATTTTTTT +TTTTGAAGAAAATTTTTTGTAAAAATTTGATTTTTTTGAAAAAGTTTGAA +TTTTGAATTTTTTGAAAAATTCTAAAAATTTTGAATTTTTTGAAAAAAAC +TCAAAATTTTTGGAAAAATTTTGAATTTTTTTGAATAAATTCAGAACTTT +TTGAAAAAATTCGAATTTTTCTGAAAAAAACTCAAAATTTTTGGAAATAA +TTGAATTTTTTCGAAAAAATTCGAGAAAATTCCTAATTTAGTCGGAAAAA +AATATTAAAAATTGATACGATTTTTGAAAAATTTTCCCAAAAATTCTATA +GAACTGTCCTGAATTTCTAAAAAAAATTCAAAAAAAAAACAAAGTTTTTT +AGAAATTTGCAAATTTCTTTAAAATTTTGGAAAAAAATCTATTTTTTGTT +GAAAAGTCTGCAATTTCTAAAATTTTCCTATTTTTTCTGCTAAAACCTGC +AAAAAAGGACCCTCCCCCTAACTATCTTGTTCCTCCAAAAACCGACAATT +CTTCTGTTTTTGTGTTATAATCGTCCTTTTTCTTGTTCAACAAAACAAAA +ATTAAAATAAATTAGAAGAAACGGTAAATTTAGATACGTTTTTGCCACGT +GGCCGAGGTTTTTCACGGCCACGTGGCAAAGGCCGGCAAGAAATGCGCTG +TGGTGGGAGAGGAAATTGATAGGGAAGAAGGAAGAAGAAAAAAAAAAGAA +AAAATCAATATTTTAAAGCCAAAAAAAATTTTTCTGAAAAGACTAGCAAA +ACAGGAATGGTTATGGGTAAAGCCGAGGTTTTGAAGGAGAATTTTTGGGA +AAAAAATTGCAAAAAAAAACGAATCGGTAGGGACGGACCGGCAAGATTGA +TTGAAAAATTGACGAAATTATCGATTTTTTGGCGGCGCACGGGGTTCTGG +CCTTCCCTCATAAATGGAAGAGTTTTTGCCGAACTAGGCCACCAGGTCAT +AACTGGGGTAGATTTACGGCGCGTTGCGTGTCGCGTCGCGGCTCAATTTT +AGTTGTAAAACTAAATGTATTTGTCCGTGTGAAGTACACGACTTTCCCGG +CGCGCGATTGTCAATGGAGCGCGAAAAATTAAGGGCCAGAAGTCCTCAGA +ACCCCGTGCAAAAATCGATAATCCCGTTTAGAATCGGTGAGGGCGTGGAA +AGAAAGAGATGATGAAACGGGAATGAGCAAAATTGCAAAAAAAAACAACA +AGAAATTCCAGAAAATTCCATAGAAAACGGGGTCTAAAGCACCAGATTAG +TGTTGTGCGTGGGCGTCCACTGTGACGTCATCACCTTCCACTTTTCGTAG +TTCGACTCGAGCTGATCGGAGAGCTCGCCGAGCTTGGCGAACTCGGTGAA +TGTGGCGAATGCTTCGCGGGCGAACATGTCTGTAAAATCAGAAATCAGGA +GAAAATTCAATTTTGCGCGTCAACTTTGATGTTTTTTTGTGTTGGTGAAC +TTCAGAAAATTGAATTCGCCAAATTTTACGAGCAAAATTGGGTTCTTTTG +GTATTTTTCGTGGAAATTTAACCAAAAATCGAGTTTTCTACGGAAATTTA +ACGTATTTTATCGATTTTTCATCAGAAATCAGTAGAAAATTCCGTTTTGC +GCGTCAATTTTGATGTATTCGGGTCGGTGAACTGCACCAAACTGGATTCG +CCAAATTTTACGAGCAAAATGGGGGTTTTTGCAAATTTTTCTTGGAAACT +CAGTCAAATATTGAATTTTTCGTGGAAATTTAACCAAAAATCGGGCTTGC +TACGGGAATTTAACAAATTTTATCGAATTTTATTTTGCGCGTCAAATTTG +ATGTTTTTTGTGTCGGTGAACTTCAGAAAACTGTATTCGCCAAATCTTAC +GAGCAAAATTGGATTTTTTGGGTATTTTTCGTCCGAAATTGATTTGTCCA +GTGAAATTAAACGCGATTTATCGATTTTTTATCGGAAATCAGTAGAAAAT +TCAATTTTGCGCGTCAAATTTGATGTTTTTTGTGTTGGTGAACCTCAAAA +AACCGTATTCGCCAAATCTTACGAGCAAAATTGTATTTTTTGCGTCTTTT +TCGTGGAAATTTTTACAAAAATCGTTCTTTTAAAAAAAAAATTCCACACA +AAAGTACAATTTTCACACAAAAACTGCAATTTGCGCGTAAAATATGGCGC +AATCGGTTGAGTGCGGCACGCCGACTCAAAAACACCATATTTTACGCGCA +AATATTAATTGAAGCGCCTTCACGTGGTGTCAGGTTGTGTCATCACGGTT +TGATCTACAAAAAAATGGGGGAATTTTTTGCCCAATAATATGTGACGTCA +GCATGTTCTTAGCCATGCAGAATCCGTCTAAAATCCCGCATTTTTTGTAG +ATCAACGTAGATCAAGCCGAAATGAGACACTCTGGGCTTCAAAACACTCA +CCAATAAAACCGCATTGTGTGATCGGAACGTTACACGTGTTCCGATCGAA +TACCTCCATCGTCACAGGCAGCCCTTTCTCTTTTTCTTCTCGAGTCTGGA +AAATATTGATTTTTATTTTATTCTTGGAATTTTAAATTTCAAACAGTAAA +AAACCAAAAATTATCAGTTTTAACTTATCCAAGTTAAAGAACTACAGTGA +AGAGAACTACAGAAATATTAAAAAATATATCGATGCACCAAGAGCCCAAG +AAATCTCTGAGAGCCCATATCTCGGCTCATTTCGAAGTTACAAATAAACT +GCAAACTATAAAAATATAGAAAATTAAATTTCAATTATTTTGTTAGTTAA +CAAAATTTGGCTAGAATTGAAATGAACTGGGATATGGGCTGGCAAAGTTC +ACTGAATTTTTTCTTTTTTTTTCTTTTGTTTATTTTGATCTCTACACCAG +GGGTGAGCAGCAAACGATTTTTTCCGGCAAATCGGCAAATCGTTAGCTTG +CCGGAATAGAAAACTTCCGGCAAATCGGCAAACCGGCAAATTACCGATGT +GCCGAGTTTGCCGGCAACCGTATGTTCCCTATGAGTATGGCCACCCATCA +ATCGACTTTGTCGGCTTATATTTCAGCGGTTTCAGAAGTTTTTTGATATT +TTCAAAAACCAGAGGATAACGATAGATTTGAAAAATATTTTGTCGTTTGA +ATTTTTAAAATATGATAAAAGACAACCGAGATATAAACGGTCAAAGTCAA +GGGGGGCCATACAAAAATTTTTTTTTGGAAATTTAGAAAAAAATGTGTTT +CCGTCTTATTAAAAAAATCTCTCTAAGCATTTCCGGCAAACCGGCAATTG +CCGCCCTCCCCCGACCTACGCACCTGTTCAAAGTACTCCTCAACAATCCG +ATGCGCCCATCGCTGACACAATCCCCACTCTCTCGCCGGATTGGAGATGT +CGGCGCACTTGACAAGCATATCACATATCGTAAGTGAATTCGTGTCACGT +TGCTCCTCCGGCACATCTGTCACATGCATCTTGTTGAACTTGGCGAGGTA +CTCAAAGTGTCGACTGATGTCCGTAGCCAACACCATCTCCACCATCGCAT +GTCGCATTTGGATGAACTCCTCGCGCGACAGACTCGAGAAGATGTTCACG +TTGGCGTTGTGCTGAAGGGTTAGCTGAAAGGCTAGTGCGATGTGATGATT +CTCCAGGATCGAGTTATCATTGTAAAGTATTGCAAGCGACTGTCGCGTAT +TGATCAGGTACGCGTTTCCTCTTCCAGGATGGTCTAGATCATGCACCGCC +GCTGCGAGAAGAGCCGCCACCGCATGACTTTCATTCACGTGCACGGCGAC +CGACGGGGAGTCCAGGAAGAATGAGGTGGCCTGTAGGACGTCGGCTGCGT +GAGTTGCGTTGTGATACGTGTTTCCCGCATGGTAATGAGCCTCGATGGAT +AGAATCCAACGGTGGAGGAGATCGTCGGAGCAGCCGAGCACATCGCAAAC +CTTCCACCTCTCGAAGACTTTCATTCCGACTTGGGAAAGAGCGTGGTGAT +CCGACACCTTTTCCAGATGAAGGATGTCGAATTTCCAGCAATTGTCGTTT +TCCAGCGCGTTCTTCACGTCAGCAGATACCCGCCGACGTTCTCCATGGGA +TCCTCGCTTCTCTCGATGCGCGTCGACGACGCTTCGCTTTCGCTGCCTAG +CTGGATGATGGAGGCGAATGAGACCATCGTAATATTGAGTTGCTATCCGA +TCGGCGTCGCGGAATCGATTGATCGACGGCGCGTACAGCTCGTGCGACGA +CAGCACCTTCATCGCGTCCTTTATCGTTTGTGCCGGTTCTCCGTCGACCC +GTGCCGACACGTCTCGGAGCATTGTGAGCACCTCGGAGATGGGCGCCTCG +ATGCCGCCCGTCTGCGATTTCAGGCTTTTCAGGGAGACGTCGCGGAAGAT +TGCGGCGGTGTCACCGGTGGTGTTTGAGCGTTTCATATACACGAATTGAC +TACTGCAAAATTCATAGAATTTTTTGATTAATTGGTGGCCGAGTTTTTTA +AAATGGTGGCCGAGATCTTTAAGTTGATGGCAGAGTTTTATAGGTTGATG +GCCTAGTTTTTTAAAATGGTGACCGAGTTTCTATGCAATTTTGTGGCCGT +GTTTTTGTATAAGTTGGTGGCCGAATTTTATAAATTGACGGCCGAGTTTT +ATAGGTTGGTGGTCGAGTTTTATGAATTGGTGGACGAGTTTCTATACAAT +TTTGTGGCCGAGTTTTTGTATAAGATGGTGGCCGAGTTTTTTCAAAATGA +TGGCCGCGATCTTTAAGTTGATGGTCGAGTTTTATAAGTTGGTGGCCGAG +TTTTATAGGTTGATGGCCGAGTTTTTATGTAATTTGGTGGCCGAGTTTTA +CAAGTTGATGGTCGAGTTTTATGAATTGGTGGCCGAGTTGCTATACAATT +TTGTGGCCGTGTTTTTATATAATTTGGTGGACGAGTTTTATAAATTGGTG +GCCGAGTTCTAACGGATTAAGCAAAGGAAACTAGAACAGAATTTTATTGA +AGAGAAAACTAGGCCATCAGCTTTTCAAGAAAAACTCGGCCACCAAATTT +TCCAGCAAAAAACTAGGTCGCCAGTTTTTCCAGCAAAAAAACTCGGCCAC +CAAATTTTCCAGCAAAAAAAACTGGGCCACCAAATTTTCCAGCAAAAAAA +AAATCGGCCACCAATTTTTCCACGGAAAACTAGGTCATTTCATTGTTCGT +TTGAGAGAAAGCTAGGTCACGTACATTTTCAATAAGAAAACTCGGCCACC +AATTTCTTGAGCATAAAAAATTCGGTCATCAATTTTTATAGAGAAAGTTC +GGCCATCAAGGTTGAAAAATAAGCTAGGCCACCGATTTTTTTTGTTGAAA +AAAACTCGAACACCTAACCTATTTTCCTTTTTTTTTCAAGCCTAGAAAGC +TCGGTTATCGAGTTTTTAGGCCACCGATGCATTTTTTTAATCGAAAATCG +AAAAAAAAAATCGGTGGCCGACTTTTTCATTTACGGCCACCAATTAAAAA +AAACTCACTTGTTAGCAAACGGGACCCGTATAAATTTCCAGTCGCAACTC +CGCCGCCGCTCCTCTTCGCCACGTGCCCTCGGCAGGGACTTTCGTCGCAT +TTCCGATTCGGGTTGTCCGATCACCTCGGATCGTATGCATCCCGTCACGT +TCTCGTAGGCGCGGTTAACGTACTGCACTACTCGTTGCTCATCACATATT +TCCACTGCTTGATCCGTCTGAAAATACGCAAAATTTGAAGGTTTGTAGGC +ACACGTGGCGCCAGTCTATCCCATTACGGTTTGATCTACAAAAAATGCGG +GAATTTTTCACCCAAAAATATATGACGTCAGCTAGTTCTTAACGATTCTC +AACTCCCGCATTTTTTGTAGATCTACGTAGATCAAGCCGAAATAAGAGAC +ACTCTGACACCGCGTGTAGGCAGGTAGGCGTTCAGCCAGGCGATTAGGCA +GGCAATTAGGCAGGCGATTAGGCAGACTAGTAGGAGGTAGGCAAGTAGGC +ATGGAGGCCAAAAGCTCACCTCATCCAAGACGGCGAAAAGGGCGGGCAGC +GCGCGGATCCGATTCGCGAGCCGCCCGACGTAGTCGAAGAGCACCACGTC +ACGCGTATTCCACGTCACATGCTGAAAAGAAACGAATGAATGGGAATCAG +TGTGAATGAAATATTAATTAGAATTGAAAATGAGAAAGTGAGAAAACGGA +TGACTTACATGAATGATGTTGGACTGCGCAAGAGCTCTCCGTCGCTTTTC +GCTGATGTGTCTGGAATATGTGATTGTTAGATTGACAATTCTGGCAGAGT +GGTCTAGAAAATTGGGGAAAACTCGGCCACCGATATGTTTTCTTTGGTTG +TGGTTGGAAAATTTTGGCGACCGAGTTTTTCAACGTATCCAAATTTATGT +GGCCGTGGCCGACTAAGGCCACATAGAAAAGAAAAATACCGAAACAATTG +GTGGCCGAGTTTTATCAACGTAGCCTAAATTAGGTGTACTTGGCCGAACT +TTTCTTCTGACGGCCACGCAGCAAGGAAAAAATAATGAAAAAAAAGTTGG +TGGCCGAATTTTAAGCCTACACAAAAAGTTGGTGGCCAAATTTTAAGCCA +ACAAAAATTGGGGGCCGAGTTTTTGTTTTTTGAAAAAATTCGTGGCCGAG +AAAATGGGAAAACGCGGCCACCGATATTTTTTCTTTGGTTTCTGGCTGAA +TAATTTTGGTGGCCGAGTTTTTGTTTTGGATAGGTTGGTGGCCGATTTTT +ATCATTTTAACCTAATTTACGTGTTCTTGGCCGAACTTTTTTCTGACGGC +CACATAGCAAGGAAAAAATAACGAAAAAAAAGTTGGTGGCCGAATTTTAA +ATTCACAAGAAAAGTTGGTGGCCGAATTTTAAGCCTACAAAAAGTGGCGG +CGCTTTTTCTACAAAAAATTGCTGTCATTATTTTAATTGGAAAAACTTGT +GGCAGTGATTTTGTTTTGAAAAAAATCGTGGCCGAGTTTATCTGTAAAAT +TGGTGGCCGAGTTTTATTCACGTAACCTAATTTACGTGGCCGTGGCCGAC +TAAGGCCACATGGCAAAGAAAAATACCGAAACAATTGGTGGCCGAATTTT +TAGTCTAAAAAAATGGCGGCCGAGTTTTTGTTTAAAAAACCGTATTTAGT +ATATCTGGGACGAAAAATGGTGGCCGAGGTTTTTCAATGTATCCAAACTT +ATGTGGCCTTGGCCTATAGCCTAGCTTTCCTAAACCATTTGTTTAAAAAG +TTGGTGGCCTAGTTTTCCAGCATAATCCAACTCACTTCTCGGCGATCGAC +ACAATCAACACCTCCTCTGTGCTCACCGATGAGACGTCTCTGAAAAAACG +TTTCGTTAGTAGATCATGGCTGACGATCAACGCTGCTCCCTTACTTGGCG +ATTTGCGATGGATGAGGTACTCGAAGATCTATGAATACAGCTAAAGGGCA +TATTGATTCAACGTCGGATGTTGCCTGCAAGAAAGTGTACATATTCAAAA +ATTTCCAAAATTCAATTTCCTTTTTCCCGCCCGTGTCCGAATTTCCGGAA +CTGACCACGTTTCAGTCATGGTCTTCGTAATTCCCAATTTCCTTTCTCCC +TTATCTTTTTACGTCAATCATGATAGCGGTGATACGTGTTTCGAGGGTAT +ACATGCTCACACAACAATGCACTTAATCAGCTAATCTCTCCCACACCTCC +ACAGAGAGAGTGTATGAGCAAGAGAAAGAGCACCTGCTTCTTCCAGATTA +GTGAGCGAGCCTGTTGTCATCTGACTTCTGCTGACGGAGGGAGCTTGAAA +AGCGGAGCAGGAAGAGGAGAAGAAAAAGAGCATTCAGAGATAATTACGCG +CGAGTCGTAGTAGTATGTATACACTGACTTCTTCTTCTTCTTCTTCCTCT +TTTTCCCCGTCTTCTGCTCGTTGATGTCTGCCATTATATTGATCATTAAC +GAGGGCCTAAGAATCCTGGAAGAGTTGTGAGGTCACACTGATGGCCTAGG +AATCTCAAAGGCAGGCCATATCATATTGCAGGCCATATCAGGCCCCATAG +CCTGGCCATAGTAGGTCACCACAAGCTATGGACTGCCCTCAAGATTTTGG +CTCAATTTGGATAAGCTTCTTCGGAGCCCCTGGGCTTAACAGACTGACGT +CATAGGTGGTATATCTCGGCTAGGCGGAAACTCGGAAATGTGAATTTTTT +GACGCAAACCAAAGATCTTATAGATCCTTGAAATCTTCCACAGGACTTAG +CAGACCGGAGGCCTGGGAACTATGCAGTTAGAGGTAATCGCCAAGTCCAG +GGCTCCGAAGAGAGAGGGCCCAGGGCTCCGAAAAAAGCTTAAATTTTGGG +CCAAAATTTCCCAAATTGGGCCAAAATTTCAAAAGTATGTAGTAGGTTTC +AACCCTCATATTTCCCGGGATCATGATTTTGTGGACTATTATTTTCAGGC +TGTGGTGGCCTGCTATACCCAGACTATGTACTGGGCCAAGCTCTGGCCAG +GTTATGGCCTTTAATAGCCTTGAATTTTGGAGTCAAAGTTCTTGCAGAGC +CTAGGAGACGCTTACCACTTCGGATCAAAGGCCTGATCTAAAACTCAATG +GATCATGACCCTAGAACCTCAATTTTCATAAGCCTAATACGCAGCTACTG +GTCTAAGCTCTGACCAGGCTATATGGCCTGATATGGCCTGAACACTTCGG +TGGCCTAGTCTAGGTTTTTCCAAGCCCCAGCGGGCCTCAATTTTCATAAG +CCTAAAGACGCAGCTACTGGGCCAAGCTCTGGCCTTGAATTTTGGAGTCA +AAGTTATTGCAGAGCCATCATGCCTAGGAGGCCTAATCTAGATTTTTTCA +AGCATTGAGGCCCCCACGGGCCTCAATTTTCATAAGCCTAAAAACTCAGC +TGCAGCCTTACCTGTGTTGGAAATGATACTGTACAAATCCATCCGGATGC +CCGTAACGAGTCGAGGAGCACACTCTCGCCGGTGCCTTCCGTCACGATCA +CAGCCTGCAAAAAACGCATTATTTATAAGATCTTACAGGGGATTTTCAGG +ATTTTCAGGAGGATTTTGTCGTGTGCCAGACCTCAAAGCTCGTCGGGATA +AAATGCTGATATTGATTGACATGCATATATATAGATATATATGAAGTTGG +AAGAGCGGAAGCAGCAGCAGTGGCAGCAGAACTTGTGTGTGACGGGGATT +TGTGGGAACAAGGCGCCAAAGAAGACGAAGCAGAAGAAGAAGAAGAAGCC +GGGGGCAAGCAATGAATGCAATGTATGTAGGAGTATGTAGGAGTATGTGT +GTGTGTGTGTGTGTGTGCGAAAGTCTCTCTATGTGTGTGTGTGTGTGTCA +CAGGTTATATATTGCGTGTGCACAAAAAATGTATGAGGTCTCCTGATGTG +TGTGTGAGTCTGTGAGTCTGTGAGTGCAGTGTACAACACCTTTTGCGGAG +TCTTATCACATACTGATACGAAAGTGTTTGTATTTTTATATTTCTTTGCC +ACGTCACACTTTATTCAATTTTTCGCGTGTGCCTCTCGCCCCGTCATTGG +CACGCAGTAGAAAAAGAAGTAGAAGAAGATGCGTCTTCTTGTTGCCATAT +CCCATCCAACTTTGTTACTTACGGAATTCGCGCGCGCGCGCGGGGAGGAG +AAGCAGAAGACGACGACGACGAGCTCGAAAGAAGACGAGTCCGCCTGCGT +CTCTGCAGTGATCTCGTGTCCCTCGGCAGCGGCTGCGGCGCGCGCTTCAA +TGAAGACGAGAGCTCCCCCCCCCGGCGGCGCCGAATACGCGATTTGTCAT +CGAGATGAGCGCTTTGCTGACAGAATAGAATGGGCAAAAACAGGAATACG +GAATACAGTAGTCATGTTTTGTTGCAATGTTATGGGAAAGCTGGCTTGGC +GTGGTCGTCGAATTTTTCGCGCTTCATTGACAAAGAACAAGGGAAAGTCG +TGTTCTCCACACGGACAATCACACTAAGTTTTAGGACTAAAATCGAGCCG +AGCCAAAATGGCCTAGTTCGGCAGAAACTCTTCCATTTCAATTTGTGAGG +AAAGCCAGAGTTCTGTGAACCTCGGACCTGCGATCGCCGACCTGCGATCT +CCTAGACAAATGCTCACCCCAGCGCGGGACTCGGGAAAGTTAGCGCCAGG +AGAATAATTTTTGAATTTGAAGAAAAAAAAAGAGGAACTTACAGTTTTCA +GCATCTTCACTTGCATCGGCCCAAACGTGTCATGTGCCGTGGAGCTGCTC +GTTGCGGCGACAGTTAGCAGAGGTGTTGGTGGAGCACCACGCGATCCACC +TCCACCACCACCATTCTCAGAATACGACCCACCGCAGCACCATCTCATTG +CAAACACTGGCCTGGATGCTGCTGCTGCTGTTGCTGCTGGTGCTCTCTGT +GCGCCTCTTCTAGCTGCGGGCGTGTGCTGCTGCCTCCTGCCAGCTTGACT +GTGTGCGCTAGCCCCGAGCACACTCTTTTCACCCTCTTCTCCCCCCACCC +CGCTTCTATCGCCCATTCTCTCAATTCTTCTCTGCCTCCTCCTCCTCCTC +CTCCTCCTCCCAATTCTCATGTCATCGGGGGGCCCGTCGTGTCGTCGAGC +GCCCTCTCGCGTCTGCAATGTCTCGGCGCCGCCGCCGTCGTCGTCGTCGT +CGTCGTCGTCTTCGGGGGGTTGTCATCTGCTGTGTTCACACTGATGCCGC +CGCCTTCACCGCCCATCTCATCGTCTCCTCCTCTGTGTGGACCCGCCGAC +CGGCCGGCGCGCCTTCTCCCATCAGTTCTATCTCTCTCTCTCACTCACTT +ACTCTCAAACCGCGTCAATTGATCTCTCTGGCACGCTCTTCGCTCGGCGA +GCTGTATTCGGTGTCGGTTTTCAGTCTGCGTCTCCGCGCCCCGGTGCAAT +GCATATGTTCCATCACGTTCTGCTCCTCTTGTTGCTCCGTGTGCTGCCGT +GTTTTACGCAATTTCAGGTAAAATTGATACAATTGATACAATTGATAATT +ATCGAAGTGTCCTCTATGTGTACTCACGCTGTTAATTTAATGGCCTAACC +ACAGAATTATGCTTCTTTAATTTTTGAACTCGTAGCTCCGTATGTTAAAT +CCACTATGAGATTCCTTGCCATGTTTTTGCAATATTTTTTTGTTTGTTAT +GAGAAAGTGTATGTGTTCTTTGTTTGGTCACATGGGAACCGCTGGCCTGA +GAATGGAAGGTTTTCTGGGACAGAGCTTTTGAATCCGATAGCCTACAATA +GGGCCCCAGTGCAATAACGGTAGGCAGGCCCGAGGCCTAATTTAGTCCAA +ATAGTCCTTATTCAGTCTAGATGATTCAAAGCTAAAATCAAAGGGCTGTT +CCATTACGTTGTGATCTACAAAAAATGCGGGAATTTTTCGCCCTAAAAAT +GTGACGTCATCACGTTCCATGCGTTATTATTTATGAAGTCTGCGTCTCAT +TCTCCCGCATTTTTTGAAGATCTACGTAGATCAACCAAGCGCCTTACCCC +TAGCCTCTAAGCTCCTAGGGCCCTCTAGGACCATTTAGGCTTTTTGGACT +GTCTAAGACCAATTGGGCTTTTAGGCTCCTAGGTCCCTCAAGGACCGTTA +GGCCTCTTGGACTATCTGAAACCATCTGGGCGTCTAGGCTCCTAGGGCCC +TATAGGACTATTTAGGCCTCTTGGACTATCTAAGACCATCTAGACTTCTA +GGCCTCTAGGGCTCTCTAGGACCATTTTGACTTGTTCTATAGGACCTTGT +TCGACTAGCTAAGACCATCTGGGCTTCTAGGCTTCTAGGGCTCTCTAGGA +CCATTTAGGCCTCTTGGACTATCTAAGACTAATTGGGCTTCGAAGCTCCT +AGAGCCCTCTAGGACCATTTAGGCCTCTTGGACGATCTAAGATCATCTGG +GCTTCTAGGCTTCTAGGCCCCTCTAGGACCTTCTAAGACCCCAGTCTTTA +TTCCCTAGCCTCTAGGCTCATAGGCCTCGATTCCGCAATTCTAATGGCTT +TGGGAGCCCAGTTCTAAGGCCCATGGACTTCCACAGTAGCTTTTCAGTCA +ACCATTTCCAAGTTAACCAAGGACCATTTAAGCCTTTTGGGCTATCTAAG +ACCATCTGGGCGTTTACTTTCTAGGCCTTTTCCTGCCTATTGGGCCCTCT +TGGACCTTCTAAGACCCTGGCCTTTAATCCCTAGCCTCTAATCCTCTAGG +CCTCGATTCCGCAAATACAATCCCAGTTCTAGACTCTCAGGGCCCTTGGG +CTTGTAGGCTTTCAGTTAACCATTTCAAACAGGTGCCGTTCCGCTCCATC +TCTTCTTGCTCTCTCGTGCTCCTCTCCTACACCATCTTCTCTCATTGTTC +TGACGGATGGATGAGCTGTCATCATCATCATCAAAGCTCCAAAGACAATT +GCCATCAATTTGTGCCGCCGCTGTGCTAAGTGGTCTTATTCCGCCGGGAC +AAAAAAAAAGGGAAAATTCTCTGGGAATTTGGACTAACACCACCTACTAT +TACTGTAAAAAAACATTTGGAGAAGGGGGAAACGAACTAAAAAAAAACAA +ATTAAAATCGGCGTATCAAATTGAAATCATATGATTCGTTGCCGTCGTCT +TCTCTGCAATGATCGTTTGTTCCGTCGTGTCAAACTAACCTACTCAATGT +CATAAAGAACAAAGAATGAATTCAATAAAACAAGACGAAAAAATAAATAC +ATTCAGGTACTGTACAGAGAGAATCAGGATCACATCTGGAATAGCTCGCA +GCCTGTTCGATTCTGGGAGCTTGTTGAGTATAGGCCGACCACTACGCCGC +CGCCGACCACTACGACAGAGTATATACCGCCACCGACGACTACGTATGTT +CCCTGAACTTTAAAGTTGCATTTTTTTTTAAAGGATTAGGGGTTTTAATT +GAAATTTCAGAATTTTTGGTAAATTTTTTAAAATTAGTTTTATTTTTTTA +CGGGCTTTTGCGATTATTACTGGTAGAATGAAAGTATGTACATTTCTTGT +AGATCAGAAAATTTAATTTTTGATATCCGATAAATGTTAAAAACTCGATC +GAAAAAAAAATAAATTTTTCCAAAAACTAAAAAGTTGCAAAATTTATTTT +TTTTACAATTCAAAGTTTGTAATTTTTGACAAAATACATTCAGAAATTTT +TTTGGAATAGGGGTTTTAATTAGGCTTGGGCCTAGGTTTGGGCTTGGGCT +TGGGCTCAGGCTTAGGCTTATGGTTAGGCTTAGGCTTAGGATTGGGCTTA +GGCTTAGGCTTGTGCTGAAGCTTGGGCTTGGGCTTAGGCTTCAGCTTAGG +CTCAGGCTTAGGCTTGTGCTGAGGCTTGGGCTTAGGCTTAGGCTCTCAGG +CTTAGGCTTGGGCTTGGGCTTGGGTATGGACTTAAAATTTTTTTTCAAAA +ATTTTATTTTTCGAAAACTTATGGTTTTACCGGTATAAAGTGCCTTTTTT +TGTACATAAAAAATAATTTTTAAATTTTTTAACGTTCCTAAAAACTAAAC +AAACTGTAAAGAAAATTTTGTTTAAAAAAAAAATCAATAAAACATATTTT +CAGTAATTTCCAAAATTTGATTTCCCGGTAAAAATCAACAATTTTTTATC +GGGGCCACAAAAAAAATTCGCTGAAAAAAATTCAATTGGATGTATTTTCT +GCAAATTCGAGTCAATTTTCTGAAAATAGTTGTTTATTTTCCCTGATTTT +TTGGCGTTTTTTCCTTTTTTAAAGGAATTTTAGGACTTTCTGGGATTTAG +AAGGGTTTAGCCTAGGGAGTGATTAAGCCTAGGCTTAAGCCTGAACCTGA +GCCTAAGCCTAAACCTAAGCCTAAGCCTAAGCCTAAGCCTAACATCAAAA +AAACCGGAAAATCCTAAGCCTAAATAGCGTCAGTAGCAAGCTGACGCTCG +CCACTGACACCAAGCCTAAGCCTCAGCCTTTAACGAAAAACAATTTTGGC +ACAAAAATTGCAAAATTTCCGCTTCTCCGCTTCTCTTAAGACATTGAATT +TCCAAATTTAAAAATTTTTAGAAAAAAAAAAACCTCGGTCCAAAATGATC +TGAAAATTCTTATTTAGGCTTTAAAAAATTTCACTTTTTTCTGCGACACT +TTCCATAACACCACAAATTCGGCGAATCGACCTGTTGATGATCTTGTCTC +GACCCGCTCTCTCTCTAAGTGATTATAACAGAGATACACCCACACACCCA +CACACGTCATCTATTATGTTCTAGAACTTTATACTTTATGATCAAAACCG +AATGCTACAAACTAAAAAAACATCACCACTTTTTCCAAATTTTCGTCACA +TTTTTGCAGTCCGACCACAACTACAACCACCAAAGATCCATGTGAATCAT +CGCATCCGTTGGATCTGACGCGTCGGCTACGGGACACTGCCGGCTACAAT +CGTATCTATATGGCCAGCGACTTTTCGTCGGCTCGCAATGAGTTTCCTGA +TCTCAGGGGTTTGGCTCACAAAGCTTCAACGGACTATCATTGCGGGAAGA +GGTGCCAACGGTGAGCTCTCAATGCCTACCTGCCTACTTGTTTGCAGTAT +CAAACATATAATGCCTACAAGCCTACGCGCCTACCTTGGTCTACGAGCCT +GAACTTGCACATTTTCTGTGCCTAACATGCACGCTATACTTTTGTCTGCC +GTTACGCGCCCCCCCCCCCCGCCTATCTGCCTACAAGTCTCCCTTTTGTC +TTTATGCCTACGCGCCTATCACATGCCTACCTGCCTATTTGCTTGCGGTC +GAGTCGATACATATCATGCCTACGAGCCTACGCGCCTACCTTGGGCTACT +AGCCTGAATTCGCATTTTTCCAGTGCCTAGCTTGCGCGCTATACCTATGC +CTGCATTTACGCGCCTTCTCCCCGCCTAGCTGCCTACAATCGCACTTTCT +GCCTACCTGCATGCTTTCCTACCTATTCGCATACTTAGGCGTACCTACCA +CAAGCTTAGCTACCTACAAAACTGCCTTCTGCCAACCTGCATGACTGCGT +ACCTTTTCGCCTGCTTAGGTGCCTACCACAAGCCTCCCTTTTGTCGATAT +TCCTACGCGCCTATGGCATACCTACATGCCTACTTGTTTGAGTCGATACA +TATCATGCCTACGCGCCTACCTTGGCCTACCTTGGCCTACAATCCTGAAA +TTGCACTTTTCCTGTGCCTAGCTTGTACACTATACTTATGCCTGCCTTTA +CGCGCCTTCTCCGCGCTTATCTGCCTACAAGCATACCTTCTGCCTCCTTG +CATGCCTACATACCTATTAGCCTGCTTACGCGAACCTACCACAAGCCTAG +CTGCCTACAAACCTCCCTTCTGCCTATATGCCTACGCACCTAACTCCTGC +CTGCCTATACGTCTACCTCATGCTGAAAACAGACCTGCCTTGTACCTACC +TATGCGCCTACCTAAGATTTGCCTCCTACGTGCCTGGCTGCCTATTTTGC +CTATAGGCATTACTGTCAGTGCGTCTACCCAGAGCCTACCTTTAGGTAGA +CGTTTGCCTACCTAAAGCAACCGCCTACAAGTCTATTCGCCTGCCTCCTT +GCCTACCTACACACCTCCCTTATCCCGGCTTTTCCACCTGCCTATGCGCC +TATCTCATGCCTACCCAAGACCTGCAAACGTGCCTAGCCGTATGCCTACC +TAACTTCGCGCCTACATATGCCTCCCTTTCAGATCGAGTCAACTAATTCG +AAAAATCATAAAAACCGGCCAACCGGCAGAAGCCGAACGTGCTTGGTGGG +ACGAGGAAGAGTGGGAGGAGGGCGAGAGACGCAGGAAACGAGCCATCGAA +TGGAAGGATACAGATGATCGTCTGCTAATGCGAAATACCGGAACATCACG +TCATATTTTGGGTAGGTAGGTGGGTGAACACAGCAAGTGCGCTCCATCGC +GCGGGACACTTTTCCCGCGCTTTTTAGGAGGTCAAACACGGAATTTTTCC +AGGAATGACTGTGGCGGTGGAATGCGATGATGAGACTGGAGAATTTAATA +GTGGTGGATACTCGTTGTGTACTACGTGCCGTGCTGTTCGACACTTGCCA +TCCACGTATTTTCCACGTGTCATTAATGAGCTGATTTGCTCGCAGAAAGC +GTGTTTGCGAGGAGAAGGAAAATGCATACAACGGGTTATGCCGATGAAGG +TATGTAATTTTTTTGTTTTTGCAATGGAGCGCGTTTGTACTCACTCCACG +AGAATCACGTGGTGTCAGAGTGTCTCATTTCGGATTGATCTACAAAAAAT +GCGGGAGAAGAGACACAGAGTTCTCAACTGATTTTGGATGATTAAGAACG +TGCTGACGACACATTTTTATGGGCAAAAAATTCCCGCATTTTTTGTAGAT +CAAATCACTTGGAGAATATTATTTTTATTTGAATATGATCCTTTAAAGAA +AAAATAAAATTTGACTGAATTTCCCGCCAAAAAATTTTCGCAGAAAATTT +AAATTTCCCGGCAAAATATTCACGGATATCTGGCTTCCCTCATAAATTGA +AATGGAAGAGTTTTTGCCGAACTAGGCCAGGCCATATCTGGGGTAGATTT +ACGGCGCGTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAAA +TATATTTGTCCGTGTGGAGTACACGACTTTCCCACGCGTTGGTGATTGTC +AATAGAGTGCGAAAAATTCAATGAGGAAGGCCAGAACCCCGTGAATATTT +TCTCAAACATTTTTTTTGGAATTAATGTGCAATCGCGCTCTAACGCAGTA +TCCAAAACTTGGGTCTTTTGGCGGGAAACCCGAAAATTCAAAGTTTTTTG +CTTTAAAATATCGTGAAACAGACGAAACTAGTCGCAAAATTTCAAATTTA +CGGTCTTGCCGCGCCAGTGCGGTGGATCACGATTGCACTTAAGAAAAATG +GCGAAAATCAAAAATTTGGTTTATTTTTGGCAACTATTTTTCATTCTCTA +TCAAATTCATACTGTACACGTGGAAAATCATTGATTTTCCCGAAAATTTG +AATAAATGGGATGCAAGATGCGAGCGCGCCCTATTGTGATTCGTTAAAAT +TCGTTAGAAGCGTCACTGAAATCGAAATTTTTTCTCGAAAAATTGCAGTG +TGCCACGTTGTAAAATATCGATTTTTTGGAAAATTTAATATTTAGAAGTG +CGGATGCATCCTATTGTGCTCCAATAAAATTACACGGGCTTCTGGCATTC +CGCATTGAATTTTTCGCGCTCCATTGACAATCGCCCGTGTACTCCACACG +GACAAGTGCATTTAGTTTTAAAACTAAAATCGAGCCGCGACGCGACACGC +AACGCGCCGTAAATCTACCCCAGATATGGCCTGGCCTAGTTCGGCAAAAA +CTCTTCCATTTCAAAATATGAGGAAGGCCAGAACCTCGTGGAAAATATCG +ATTTTTCCATTTCCACGTGGCCAAAGGAATTGCAAGCGCGCTCCAGTGAA +CTCGCCCAATTTCCATTTTTTTTCAGGTTCTCCGAAACGTGGGCACCCGC +GAGTGTGCTCGCTGGCAAATGAGCCAAATCGACGTGCGAACGTGTTGTGA +TTGTATGCTCAATCCGTCATCACCACTGGTCACCTATTTATGAGCGAAAA +AACCGGGGAAAAAAACACACAAAACAACTCAAAACTCAACAAAAAAAAAT +AATTTTACAAGATTCAACGAAACAACAAAAAAAAGAAACAATGGAAATTA +AATACGGATGCTGCTGCCAAATATGCTGCCAAATTCAAATTCTCGCCTTG +TACACACGATCTTTATTGAAAACGGTGATCAACGGGCACCCTCCACTCTG +ACCTTTTATCTGAAAATAATTGTTTTAAAGATTTATTTGATTAAAAACCT +CGGCCACGGCCGCGACGCAGCCGCTCCGCACGCAGCTGCGTCGCGGTCGG +GTGGATCCTAACCTGAACTTCTCCCTCCAGCTCGTTATCGTCGTCGACCA +CCTCGAACAGTTTGCTAGCCTCGAATAGAAATCTGAAAAAAATAAATTGG +TTTTTTTTGAAAATATATAATGTTTTATGTTTGGGCTTCTGGCCTTCCTC +ATTGCATTTTTCGCGCGCTCCATTGACAATCGCCCCCCTGTGTACTCCAC +ACGGACAAATCACATTTAGTTTCACAACGAACGACACGCAACGCGCCTGG +CCTAGTTCGGCAGAAAAACTCTTCCATTTCAATTTATGAGGGAAGCCAGA +AATCCGCGTGTGTTTTATTGATTTTATTGATTTTTTTACTTTCGAAAATC +GCGTTCCGGCTGGTAGAAGCACAAGGTTTTGCGCGTGTCGGCGATTCGAT +CCCTCGACCATTCTCTGCAAAAAAAATATTTTTTTTTGTGTAAAATTCCC +AATCTGCGAGAACGGGATCTACGAAAAATTTTTTTTTTAATATTTTAATG +ATTTTTTCAGAGATCACATTCTTGCAGATCATCTTTTCGTGGGGCCTCCT +AATTTTTCAGTGCTGCACATTTATTTAACATTCAAAAGTGCTTTTTTCAT +AAAAATTTGAATTTTTTGCCCAAAAATCGAGAAAAACGCCGCTCCGCCTC +TTTTTCCGTGCGGCACTGTGCCTTTTGCAAGCTGGGCACAGTTTTGTAGG +CGTGAGCATGGTCTTACTTGAGCGCTTGAGTGATCTACGAAAAAAAAAAA +GCTTTTTTTAAAATTTATGTCGGAGATCACATTCTTGCAGATCATCTTTT +CGTGGGGCCTGCTTATTTTTCAGTGCCGCTCGGAAAAAGAGGCGGAGCGT +CGTGAGGCACGGTTTTTTGTCACGATTTTACAGTTTTTTGACTAAAATTC +TTGATTTTGGATCATTTTCGTTGATTTTTTTCGGAAAAAGCTGATTTTGG +CAAAAAAAAAATTTTCGCTTTTTTTTGGACAAAGAAGAGCCAAAAAAAAA +AATGAAAAAATCATAAATTTTTTAGTTTTTACATTTTTTTTTTTGAATTG +AAAAATGTTTTTTTGTGTTTTTGGTGAAAAAAACTACTTTTTTTTGCGAA +AAAAAAATAGCAAAAATGACCAAAAATCGGAAAAAAAAAACGCCGCTCCG +CCTCTTTTTCCGTGCGGCACTTCGCCATTTGCAAGCTGGGCACGGTTTTG +TAGGCGTTGTCATGTTGTCATTACTTGAGCGCTTTGAGGCAAAGACTTAT +GGGAGAACGGTGAAATCCAAAATTGGTGGCGTTCGGGAAGAGACGGGGGT +GCTTCTGAAAAAAATTGTTGAAAAATGCAAAAAATCTGAAATTTTAGAGC +ATTTTTCTGAAAAAAATGCAAAAAATCCGAAATTTTTGAGCATTTTTCTG +AAAAAAACGCTAAAAATCTGAAATTTTAGAGCATTTTTCTGAAAAAAACG +CTAAAAATCTTAAATTTCTGAGCATTTTTCCCGGAAAAAAAAAGATTTTT +ATGCACCTCTGCGAAAACTTCATCCATCATGGTAATTGAAAAATCACAAC +TGTCCAAAAGCACCGAATTCACAGTGTCGAGCTCGAAAACGCCGACATCT +TCGACCTAAAATGCTCAATTTTAATGGGGAAAAGCTCTAAAATCATGGGC +TTCTCGCATTCCTCGTTGAATTGTTCGCGCTCCATTGACAATCGCCCCCG +TGTACTCCACACGGACAAGTGCATTTAGTTTTAAAACTAAAATCGAGCCG +CGACGCGACACGCAACGCGCCGTAAATCTACGAAAAAAAAAAGGAATTTT +TGCTGAAAAATCGATAAAACACGTTAAATTTAACCAGAAAAATCAATTTT +CGCACAAAAATTCGCAAAAAAAAAAAATCAAATTTTGCTCATAAAATTTG +GCGATTTCAGTTTTCTGAGGTTCACCGACCCAAAAAACGTCAAATTTGAC +GCGCAAAACTTGAATTTTCTATTGATTTTTGATGAAAAATCGATAAAATA +CGGTCAATTTAACCAGAAAAATCAATTTTTAACGAGAAAAGCCAGAAATC +CGTTGAAAAAGCTCTAAAAATCAAAATACAAACATTCGAGAGAGTCAGAT +GACGGAGACAGACGCATTTTTTCAGAATTTTCTGCAAATTTAGGTCCAAA +CTGACGAAATAGAAGACACGGAGCACACTGGAAATGAAAAAAAATTAATT +AAATGCTAGATTTTTAGCATTTTTTCAGAAAAAATGCACTAAAATTTCAG +ATTTTTAGCATTTTTTTCCGGAAAAATACACTGAAATTTCAGATTTTTAT +TTATTTTTTTTTGAAAAAATGCTACAGACCGAATAGTTTGCCAGGCATTT +CTGCCGCGGAGGAAATCGGCGATGAACTCTGCCACGTAGCGGCATTCGAT +GGGCGGTGGCTGAAAATTTGCAATTTTTTGGCCTAAAATTTGGTTTTTTC +TGGAAAATTCTCTTACCAACGGGAAGGTTTTCGTCTTCGGAATGCCTAAA +TTAACAATACAAGCCCTCGGAGCAATTCTCGCAAGAATTGGAGCCAGCTC +CTTGGCATAAGTGAGATCATAGATGAAGAAGACGAGCCGCTTCACCATTA +CGATGCTCTTGCAGCGTTCACGGCGTTCTGCGTATTTTTCCAGGATACTC +TGAAAAAAAATCCGTTAATTTTAGCCAAAAAATCCGTTAAATTTAGCCAA +AAAATCCGTTAATTTTAGCCAAAAAATCCGTTAATTTTAGCCAAAAAATC +CGTTAATTTTAGCCAAAAAATCCGTTAACTTTAGCCAAAAAATCCGTTAA +TTTTAGCCAAAAAATCCGTTAATTTTAGCCAAAAAATCCGTTATTTTAAG +TCAAAAAATCCGTTATTTTAGCCAAAAAATTCGTTAATTTTAGCCAAAAA +TTCGCTAGTTTCAGCCAAAAAAATCCGTTAATTTTAGCCAAAAAAGAACC +GTTATTTTTAGCCAAAAAATCCTTTAATTTTAGCCAAAAATTCGATATTT +TTAGCAAAAAAAATCCGTTAATTTTAGGCAAAGAACCGTTAATTTTAGCC +AAAAAATCCGTTAATTTAAGTCAAAAAATCCGTTAATTTTAGCCAAAAAA +ATCCGTTAATTTAAGTCAAAAAATCCGTTATTTTAGCCAAAAAATTCGTT +AATTTTAGCCAAAAATTCGCTAGTTTCAGCCAAAAAAATCCGTTAATTTT +AGCCAAAAAAGAACCGTTATTTTTAGCCAAAAAATCCGTTAATTTTAGCC +AAAAATTCGATATTTTTAGCAAAAAGAATCCGTTAATTTTAGCCAAAAAT +CCGTTAATTTTAGCCAAAAATCCGTTAATTTTAGCCAAAAATTCGATATT +TTTAGCAAAAAAAATCCGTTAATTTTAGGCAAAGAACCGTTAATTTTAGC +CAAAAAATCCGTTAATTTTAGCCAAAAAAATCCGTTAATTTAAGTCAAAA +AATCCGTTAATTTTAGCCAAAAAAATCCGTTAATTTAAGTCAAAAAATCC +GTTAATTTTAGCCAAAAAAGAACCGTTATTTTTAGCCAAAAAATCCGTTA +ATTTTAGCCAAAAATTCGATATTTTTAGCCAAAAATCCGTTAATTTTAGC +CAAAAATCCGTTAATTTTAGCCAAAAATTCGATATTTTTAGCAAAAAAAA +TCCGTTAATTTTAGGCAAAGAACCGTTAATTTTAGCCAAAAAATCCGTTA +ATTTTAGCCAAAAAAATCCGTTAATTTAAGTCAAAAAATCCGTTAATTTT +AGCCAAAAAAATCCGTTAATTTAAGTCAAAAAATCCGTTAATTTAAGTCA +AAAAATCCGTTAATTTTAGCCAAAAAAGAACCGTTATTTTTAGCCAAAAA +ATCCGTTAATTTTAGCCAAAAATTCGATATTTTTAGCAAAAAGAATCCGT +TAATTTTAGCCAAAAATCCGTTAATTTTAGCCAAAAATCCGTTAATTTTA +GCCAAAAATTCGATATTTTTAGCAAAAAAAATCCGTTAATTTTAGGCAAA +GAACCGTTAATTTTAGCCAAAAATTCGATATTTTTAGCCAAAAAATCCAT +TAATTTTAGCCAAAAATTGCTAATTTTAGCAAAAAAATTCGCTATTTTTA +GCCAAAAAATCCGTTAATTTTAGCCAAAAAATTCGCTATTTTTAGCCAAA +AAACTGTTAATTTTAGCCAAAAATCCGTTGATTTTAGCCAAACAATTAGT +TATTTTTAGCCAAAAAATCCGTAAATTTTAGCCAAAAAATCTGTTATTTT +TAGTCAAAAAATTCGTGAATTTTAACCGGAAAATCCGTTATTTTTACTAC +AAAAATAGCGAATTTTCGCCAATTTTAACCAAAATCTCTCGATTTTTTGT +CAAAAATGCACCAAATGTGCGCTTTTTTTCGTTTTTTTTTGGCATTTTCC +CTACTTCAATAGCGAGTTTGCAGGTCGTCGTGCAAATTTTGACTTCGATT +TCAACAGAATCCAGCAGAATTCGATCATCAGTCATACATTCCAAACAATT +TTCAGCATCCTTTATGGGCACTTCGATGAAATCTGAGAGAGCAAACACTT +TAGAATTGCCAGGGTTTACAGCTCTTTTAATCACCATCCAACTGGCACGC +GACGTCCATTTTTGGCTGCCCATTCACCCGCTCGCCGCCACCCTTGCAAA +TGTTGTGAAATTTGATGACAAACGGTTCAGAGTACTCGAAATTCTCCAGA +TCGCCGTGCTCGACGAGCTCGTTGTTCGATGGTGCTCTTTCCGGCGTTCT +TTTCCATCTGAAACTGCTGTTTTTCCTTTTTTTTTTTGTCGCAAAATCTT +TTTTTTCACCGAATTTTTCCACCAACCTGAACAGCGAATCTTCGAAAAGA +GACGAAGAATTCGATTTTGGGCTTTCCAAATTTGAAAAATTCAAAGAAGT +TGTCACAGAACTAGCCATTTCGAAGTTGAAATGATTAAAAATCAAAAACA +AAAAATTTCGATAAAAATCAATGTCCGAGAGGAGTACACGCTTGGGAACC +ATGCGCGGGTCTCGCACGGAAGAGACGAATTGAAGTACGGTAGCTCGTAA +ATCCTGTTCCACGATTGATTTTTTTTTAATTTTTGATCAATTTTTTCGAT +TTTATCCCAGAAGTTCTTGAAAATTATCCGTTTTTTTGCAATTTTTTCGG +AAAAATGCTCTAAAATTTAAGATTTTTAGCATTTTTTTCCGAAAAAAATG +TTTTAAAATTGCAGATTTTTAGCATTTTTTCACAAAAAATGCACTAAAAT +TAAGATTCTTAGCATTTTTGCGGAAAAAATGCTAAAAATCTTGCAAAGAC +TGAAAAAATTCGAATTTGTTGTAATATTGCATGTTTTCCGAGGTTTTACA +TCAAATATGTGTAGTTTTCCTTGAAATTTGACGTTTTTCACTGAAAAATT +CTACAAAAATAAGCATTTCTGAGCTCTTTTGTCGCAAAAGTTGATGAAAA +TCGCCAATTTTTCAATAAATATTGCACAGAAACCGTCAGATTTTTAGCAT +TTTTTCGGAAAAATGCACTAAAATTTTAGATTATTAGCAATTTTTCAGAA +AAATGCTCTAAAATTTAAGATTTTTAGCCCTTTTTTTCAGAAAAATTCAC +TAAAATGCAAGATTTTAATCATTTTTTTGCAAGAAAAATGCTCTAAAATC +TAAGTTTTTTAGCATTTTTTTCGGAAAAATGTTTGAAAATCCCTTCTTTA +ACGCCTTTTTCGCACTAAAAGATGCTCAAACTAGTTTAAACTTTCAGAGT +TTTCCCATGCTTTTGCCCCCTCCACTTCACAAGAAACAAGAAACAAATAC +GGCGGGAAAAAAGCGAAAATTCGCGGAAAACATCATTTTCAATGCATTTT +TCATCGCGAAAATTGCCGAATTTCATTAAAAATGGCCAATTTTTGTGCCA +GTTTTCCCAATTAATCATGTATTTTCGATTAACTCGAAGCCCCTGCGCAG +AGAAAAACACAAAAATGTTGCAATTGTTTGTGTAAAGCACTTCTCTGCGC +GTCTGCGGCATCCGATATGACGAGCAATATATATCTTTTTTCTGGGAGCC +TTTTATTTTAAATTTATCATTTTTCATTTAGTTTTTGAGAAAAAAATTCC +CCCAAAATTAACCTAAAAGCCTTGAAAATGTGAATTTTGAGTGAAATTTG +ACGTTTTTCAGCGAAAAATTCTCAATTTTTAGTGCATTTTTGCCGGAAAA +ATGCTAATAATCTTGAATTTTAGTGCTTAGCGGAAAAAAAATTCAAAATG +AAAATGTCGAATTTGAAATAAAATGCTTTAAAATTTAAGATTTTTAGCAT +TTTTCCCGAGAAAAGCTAAAAATCTTAATTTTTATAGCTTTTTTGTTGAA +AAAATGCTAAAAATCTTAAATTTTAGATCATTTTATTTCAAATTCGACAT +TTTCATTTTGTATTTAAGAAAAAATAACCTCAAAGTCTGAAAAATATCGA +ATTTTGAGTGAAATTTGACATTTTTCAGCGAAAAATTCTCATTTTTCCGG +AAAAAATGCTAAAAATCTTGAATTTTAGTGCATTTTTCCAGAAAAAATGC +TAAAAATCTCAATTTTTAGTGCATTTTCCCGGAAAAATGCTAAAAATCTT +AAATTTTAGAGCATTTTCCAGAAAAAATGCTTAAAATCTTGAATTTCAGA +GCATTCTTAATGAAAAATGCTAAAAATCTTAAATTTTAGAGCATTTTTCT +CGAAAAAATGCTTAAAATCTTGAATTTCAGAGCATTTTTTTCGGAAAAAT +GCTAAAAATCTCAATTTTTAGTGCATTTTTCTGAAAAAATACTAAAAATC +TTGAATTTTTAGAGCATTTTCGCTGAAAAATAATAAAAATTTTAAATTTT +AGAGCATTTTTCCGAAAAAAAAAACGCTAAAAATCTTGTAATAACTGACA +AATTTCGAATTTTGAGTAAAATGGCATGTTTTTTGAGGTTTTTCCTTGAA +ATTTGACGTTTTTCACCTAAAAATTCGACAAAAATGAGCATTTCTGAGCT +CTTATATTGCAAAAATTGACAAAAATCGTCAATTTTTCAATAAAAATTGC +CCAAAAACCTTAAAATATTCTGAAAAAAGCCGAAAAAACCCCATTTTTTA +GCCATTTTCTACAGAATTTTACATTTTTCTCAACTTTCTTCACCTAAAAT +CGCCGATATTATTCACATAAAATTCCCTTTTTTTTCAGCGCAATGGGGTG +TATTATGAGCCAGGAGGATGAAGCAGCGAAACGAAGATCCAAGAAGATTG +ATCGATTGGTAAAAATTGGGGATTTTTCGTTGAAAAAACTCGATTTTTTG +TGAAAAAATATAGAAAAATCATCAAAACTGCTTCAAAAACCGAAAAATTT +CACTAAAAACTAGAATTTTTGCTCGAAAACCTCAAAAAATCGCAAAATTT +GCAGTGAAAACTAGATTTTTATTTTTAAAAAATTCAAAAAGTTCATAAAA +ATCAATAAAAAAATCGGATTTTTTTTCTTAAAAAATCTGGAAAACTGTCT +AAAAATCTACTCAAAATCAGTTTTTTTTGTAGAAAATCTGAAAAATAGTC +TAAAAAATTAATAAAAATCGATTTTTTGGGAGAAAATTTGAAAAATTACG +AAAAAAATCAATAAAAAATCGGTTTTTTGGGAAAAACCCTGAAAAATTGT +CTAAAAATCTATAAAAAATTGGATTTTTTAAATAGAAAATCTGAAAAACT +GCCAAAAAATCAACAAAAAATCGATTTTTGTGTGAGAAAACCTGAAAAAT +TATCAAAAAATTGGTTTTTATCTAGAAAATCTGAAAAATTACCTAAAAAG +CAATAAAAAATCGGTTTTTTTTCTGGAAAAACTGTAAAATAGCCTAAAAA +TCAATTTAAAAAAAGTTTTTTTTTTTGTAGAAAACCTGAAAAATTATCAA +TAAAAACCACGAAAAACAGTTTTTCGCTTATAAAAAGTCCAAAAATCCCA +AAATTTGCATTAAAAACTAGATTTTTATTTCAAAAAAATTCAAAAATTGC +CTGAAAATCAATAAAATTGTTGTTTTTTTTTGGAAAAAAAAACCCTGAAA +AATTGGCTAAAAATCCCAAATTTTTTTGCAGCTCAAAGAAGACGGCGAGA +ACTCAATGCGAACCATCAAGCTTCTGCTCCTGGGAGCCGGCGAGTCTGGA +AAATCGACGATTTTAAAGCAGATGCGTATCATTCACGACGTCGGATATAC +GACTGAAGAGAGAAAAGTGTTCAGAGGCGTCGTTTATGGAAATATTATTT +TGGTCAGTGCTCCGATGCACTGAAAAATGACAGGAAATTGGCAATTTTGA +CCAAAATTCGTGGATTTTAACCAAAAAATCCGTTAATTTTAATCAAAAAT +CGGCTAATTTTAGCCAAAAAATTCGCTATTTTAACCAAAAAATCCGTTGA +TTTTAGTCAAAAAATTCGCTATTTTTAGCCAAAAAATCGCTATTTTTAGC +CAAAAAATCCGTTAATTTTAGCCAAAAATTTCGCTATTTTTAGCCAAAAA +ATCCGTTAATTTTAGGCAAAAAATCCGTTAATTTTAGTCAAAAAATCCGC +TATTTTAACCAAAAAATCCGCTATTTTAACCAAAAAATCCGTTAATTTTA +GCCAAAAAATTCGCTATTTTTAGCCAAAAAATCCGTTAATTTTAGCCAAA +AAATTCGCTATTTTTAGCCAAAAAATCCGTTAATTTTAGCCAAAAAATTC +GCTATTTTTAGCCAAAAAATCCGTTAATTTTAGCCAAAAAATTCGCTATT +TTTAGCCAAAAAATTCGCTATTTTTAGCCAAAAAATCCGTTAATTTTAGC +CAAAAAATTCGCTATTTTTAGCCAAAAAATTCACCAATTTTCGTTTAAGA +TTCTCCAATTTTTGACAAAAAAATTCACCGAATTTGCTCAAAATTCTCCC +TTTTTTGGCTAAAAAATGCATAAATTACACAATTAAACCAAAAATTACCC +AATTTCGCCCAAAAACTCTAATTTTTACCAAAAATTCTCCTATTTTTTGT +TGAAAATTCACCAATTTTTTTGCCAAATTTTAACAGAAAAATCTATAAAA +TATCAGGCGAAAATAACCTAATTTTGGTCAAAAATTCACCGATTTTTGTT +CAAAATTCTTCAATTTTACCCAATATCCACCAAATTTTAACCAAAAAAGT +CTAAAAAATTATTCAAAAAATCCCTAATTTTGGCCCAAAATTCTCCATTT +TTACTCAAAAATTCTCTCTTTTTAACCAAAAAATCTAGAATATTAGGTGA +AAAATGCCTAATTTTGGCTAAAAATTCACCGATTTTTGACAAAAAAAACC +TCCAATTTCAGCTTAAAACTCTCTGATTTTTACCAAAAAAATCTAAAATA +TTAGGCGAAAAATCACTAATTTCGGCTAAAAAATCACCAATTTTTGACAA +AAGAAACTCCAATTCCAACAAAAAATTCACAAAATTTACTCAAAAATTGT +CTGTTTTTCACAAAAAAAAAACCTACAATATTAGGAGAAAATTCACAAAT +TTTGGCCAAAAAATCCCTAATTTTGGCCGAAAAATTTGCCAATTTTGTTC +AAAATTCTCCAATTTTCGACTAAAAAAACCTGCCATATTCAGCAAAAAGT +TCACCAAATTTACTCAAAAATTCAAAAAAAATCTAGAATATTAGGCGAAA +AATCCCTAATTTTGTCCAAAAATTCACCGATTTTTGACAAAAAAAACTCT +AATTTCAGCAGAAACTTCACCAAATCATAGCCAAAAATTCACTGTTTTTT +ACCAAAAAAATAGAATATTAAGAGAAAATCCCTAAATTTGTCCAAAAAAT +TAAACAAATTATAGCCAAAAATGCTCTGTTTTTTACCAAAAATTCTAGAA +TATTAGGTAAAAAATCCCTAATTTTTCCCAAAAAATTCACCGAATTTACT +CCAAAATGCTCTGTTTTTGACAAAAAAAAACTCTAATTCCAGCACAAAAT +TTACCAAATTATAGCCAAAAATGCTCTTTTTTTTCCAAAAAAAATCTAAA +ATATTAGGCGAAAAATCCCTAATTTTGTCCAAAAATTCACCGATTTTTGA +CAAAAAAAACTCTAATTTCAGCAGAAACTTCACCAAATCATAGCCAAAAA +TTCACTGTTTTTTACCAAAAAAATAGAATATTAAGAGAAAATCCCTAAAT +TTGTCCAAAAAATTAAACAAATTATAGCCAAAAATGCTCTGTTTTTTACC +AAAAATTCTAGAATATTAGGTAAAAAATCCCTAATTTTTCCCAAAAAATT +CACCGAATTTACTCCAAAATGCTCTGTTTTTGACAAAAAAAAACTCTAAT +TCCAGCACAAAATTTACCAAATTATAGCCAAAAATGCTCTTTTTTTTCCA +AAAAAAATCTAAAATATTAGGCGAAAAATCCCTAATTTTGGCCAAAAAAA +TTACACCAATTTTCCCCAATTTCAGCTTAAAATGTTCAATTTCTAACCAA +AAAACCCCCAAATTTTAACCCAAAAATTCCCTCGAATTTCACCCCAAAAC +CGTCCAATTTTCCAGTCTCTCAACGCCATCATCCACGCTATGGAGCAGTT +AAAAATCAGCTTCACCACACTCGATCACGAATCAGATGCCCGAAAGCTTC +TAATGTTCAGCACAACAGGCGAAGAGGATGAGCTGCCCGAAGAGCTCGTC +GTGCTCATGAAGAGTGTTTGGTCCGATTCGGGAATTCAGAAAGCGCTCGA +AAGGTGGCGAAATTTCGCTGAAAATTGAGAAAATTCGAGGGATTTTCGCT +GAAAATCGAGAAATTTCGGTGGAAATTAGCTTATTTCCATGAAAAAATCG +TTAAAATCCCAGAAAATTGCGATTTTGGACTATTTTTGAGCATTTTTCGC +GTTTTTTCCATGAAAAATTCAATGAAATCGATTTTTTAGGTCATATTCGC +TGAAAATTACCGCTTTTTTCGATGAAAAATTCGTTGATATTCGTTGAAAA +TTATCTATTAGAGCTAATTAAAATTTAAAATTCCAAAAAAAAAAATATTT +TAAAATAATCAATCGAATTATTTTTTGCTCACACTTTCAAAAACCGCTAA +AAATTCTAAAAAAAAAATTTTGGAGCCCCTTTTCCGCTAGAAAATAGCTT +TTTTTCCCTCAAAATCCGGGAAAATTCAGAAATATTTAATTTTTTGGCTA +TTTCTGACTCTTATTCCCACACAAAAATAGTTTTACCAAAAAAAAACAAT +TTTTGTCAAAAATTCGAAAAAAAAATTTCTGGGAAATATTTTTAAATGAC +TCTAAATTTTCCCCTGTACCCGAATATCGATGTGAAAAAATTCAGAAAAA +TTTTCCGCGATTTTATATGATTTTTTGAAAATTGGACAAATTTCAGTTTT +CCCCCCTAATTCCTATTTGAGTTACCGCCAATTTGATTTGTTCGATGGAC +TTGCACATTTTTGAATTAATCTATTTTATTTTTTGTTGTTTTTTCCACCG +ATTTTTAATGTTTTCGGTGTATTTTTGCTTGAATTTTAGGGGAAAAGTCA +AAATAAATGCAATTTTCGATTAAAAAGCACGCTGACCGGCGTAAAAATGA +AAAAGTAACGATTTTAAACGATTTCAAACCTGAATTAATTAATTTCACTG +ATTTACGCCTGTACGCGTGCGTAGATCAGTGAAATTAATTAATTTAGGTT +CGAAATCGTTTAAAAGCGTTACTTTTTCATTTTTACGCCTGTAAGCGTGC +TTTTTAATCAGAAATTTGCAATTATTTTGACTTTTTCTCTAAAATTCAAG +CAAAAATACACCGAAAACATCAAAAATCGGTGGAAAATAACAAAAAATAA +AATAAATAAATTTAAAATTGTGCAAGCGCGCTCCATCGAACAAATCCAAT +TGGCGGTAATTCAAATAGGAATTAGGCAAAAACTGAGATTTTTGAGGCAC +CACGTTTTGAAGATCTGTTCAAAAAGAAGATCTACGTTTTCAGGATCTGG +CACCGTGCCAACTGCGGTTTTCTCGATGAAAAACGTAACAACGATGCTCC +GATGTTACGCGTCGCGTGTTGTTTTGCGTTCAGAAAGATATTTTTTGAAA +TTTTCTTCTTGAAGAAACGCTTAACGACACGCAACGCGTAACATCGGAGC +ATCGTTGTTACGTTTTTCATCGAGAAAACCGCAGTTGGCACGGTGTCAGA +TCCTGAAAACGTAGATCTTCTTTTCGTAGATTTTCAGAATGTAGATCTTC +TTTTGGTAAATCTTCTTTTCGTAGATCTTCTTTTCGTCGATCTTCAAAAT +GTAGATCTTCTTTTGGTAGATCTTCTTTTCGTAGATCTTCTTTTCGTAGA +TCTTCTTTTTCGTAGATCTTCTTTTTGAACAGATCTTCAAAACGTGGTGC +CTCTGATTTTTCCAAATTTCAAAAAATCATATAAAATTTAGAAAATTTTT +TTGAATTTGTTTATCAGCATATTTGGTCATTTTGGTACCATATTTTCCCC +TGATTCCGAATATCAATGTGAAAAAATTCAAAAAAAAAATCCCTGATTTT +ATATTTAAGCTTGAAATCGCCGAATGAGATTTTTCAAATACGCGCGCACA +AATAAATTCTCCTTGGAGCGCGTTTGCCTCATTTGATTTTCTCCATATTT +ATTTTTACTTTTTTTTCAGTTTTTCACAGCTATTTTCATTCATTTTTATT +GTATTTTATAGGTTTTTTTTTTTGAAAAATAAATTTTTCCGTGTGAATTG +AACATTTTATTTGCATAAAAATGAATGAAAATAGCTGAAAAACTGAATAA +AGTAAAAATAAATATGGAGAAAATTAAATGAGGCAAACGTGCACCAAGGA +TAATTTATTTGGGCGCGTATTTGAAAAATCTCATGTAGGAGGCAAATGAA +ATTTAGGCGATTTCTAGCTTAAATATAATATCAGGGAAATTTTTTTTTTG +ATTTTTTCACATCGATATTCGAATCAGGGGAAAATTTGGAGCCACCTGTA +ACAAAATTTTATGAAAAAAAAAACTGTATAATTTCTAACAACTTTTTTTT +TGTAGATCACGCGAATATCAGCTCAACGATTCGGCCGGCTACTATCTGAG +CCAACTCGACAGAATTTGTGCTCCTAATTACATTCCCACACAGGTATTTT +TCACTGGAAAATTCACAAATTTTTCCACTACTAAAAATTCAAATTTCCTT +TGCAGGATGACATTCTCCGCACAAGAATCAAGACAACAGGAATCGTGGAG +ACGCAGTTTGTCTACAAAGATCGCCTATTTTTGTAGGGGGAAAATTAATT +TTAAAAAATTGAAAAAATCGTCGCCGAAATTCAGGGTTTTCGACGTTGGC +GGACAGCGATCCGAACGAAAAAAGTGGATTCATTGCTTCGAAGACGTGAC +GGCACTCATTTTCTGCGTTGCACTGTCAGAATATGATATGGTTCTTGTCG +AAGATTGTCAGACGGTGCGATTTTCGAGTTTTTTGCTTTTTTTTCGTTTT +TTTCCCAAGTTTAGGGTTTTTCGGTGAAAATCTCGGTTTTCTTGGTTAAA +ATGGTTTTTTTTTTGGCAAAAAACGGCAAAAATTGAGGATTTTAGCGTAT +TTTGGCGAAAAATTGAGTTAATTACATGGAAAATTTCAGAATTTGAGTTA +AAATTGTAGTTTAAGGATTTTTTAGTGATTTTCTCGATTTTTGAACCGAA +AAACGTTCGAATTTCATTTATTACGCGCGACCACAAAATGCTGAGAACGC +GTATTGCACAACATATTTGACGCGCAAAATATCTCGTAGCGAAAACTAAA +GTAATTCTATAAATGACTACTGTAGCGCTCTTGTGTCGATTTACGGAAAT +CGTGTATTAATCGATAAAGTATTTTTTTTAGAAACACAAAAATGACAAAA +AAAATACGAAAGAAAATTGAATTGTTTCGAAAATCGAGTCCTCCCGTAAA +TCGACACAGTTGCCATTAAATTAAATAAAATTAATGTTAACTGTGTCGAT +TTACGGGAGGACTCTCGATTTTCGAAACAATTCAATTTTCTTTCGTTTTT +TTTTGTCATTTTTGTGTTTCTAAAAAAAATACTTTATCGATTAATACACG +ATTTCCGTAAATCGACCCACAAGAGCTACAGTAGTCATTTTCAGAACTAC +TGTAGTTTTCGCTACGAGATATAATTGCGCATCAAATATGTTGTGCATGA +CGGATTCTCAGCATTTTGTGGTCGCGCGTAATGAAAAGCGAAAAAATCGA +TATTTTCTGATTTTTGCGCCGAATTTTGTTAATTTTTCTTTTTTTTTTTT +CTGCGAAAACCACATTTTCCTGACTAAATTCAGGTTCAGCCATTTTTTTT +CGCAAAAATCGACGAAAATTGAGAATTTTAGCGTACTTTTAATTTTTTTA +AATTTTTTTCGCTCTGAAAATTATGAAAAAATCAAAATTTTCTCGATTTT +TGAACCGAAAAACGTTCAAATTTCATTTAAAAATCGAAAAAATCGGGAAA +AAATTTTCCGATTTTTGCACCGATGATTTTCGCTAATTTTTCACCACATT +TTTTGCGTTTCAGAATCGAATGCGAGAATCGCTAAAACTGTTCGACTCGA +TTTGCAACAATAAATGGTTTGTCGAGACGTCGATTATTCTATTTCTCAAC +AAAAAAGACTTATTCGAAGAGAAAATCGTTCGATCTCCACTCACACACTG +CTTTCCGGAATATACGGGCGCCAATAATTACGAAGAAGCTTCTGCGTACA +TTCAACAACAGTTTGAGGATATGAATAAGAGGACTACTGGAGAGAAAGTT +GGTGGTTTTTTTGAATTCACTGCAACTTTTTCCTCACGAGGGACGAGGAA +AAGTGGTTTCTAGGTCATGGCCGAGGGGCCGACAAGTTTCAGCGGCCATT +TATCTTGCTTTGTTTTCCGCCTGTTTTCTTTCGTTTTTCATCGATTTTTT +TCGTTTTTTCGTAATAAAACTGATAAATAAATATTTTTTGCAGATGCTAA +AACAATTTCCAAGTAAAAAAATCATGTATTCAGTCGGCAAGCAGCGATGA +AAGTGGGCATTGTAATATGATGGATTACGGGAATACAAAACCTAAACTTT +TTCTGAAACATGAAACATATGATGCTTAGATGCTGAAATTACCTGATTTT +CATAACGAGACCGCTGAAAAGTTTTGAGGTTTCCACAATTCAACTTTTTG +TGCGAAAATCTCGACTTTTTCACCAAAAAAGTTGAATTTTGGAAACCTCA +AAACTTTTCAGCGGTCTCGTTATGAAAATCAGGTAGTTTCAGCATTTAAG +CAGCATATGTATCATGTTTCAGAAAAAGTTTAGGTTTTGTATTCCCGTAA +TCCATCATATTGCATTGCCCTTGTTTCACCGCTGCTTGCCCACTGAATGC +ATAATTTTTTTACTTGGAAATTGATTTAGCATCTGCAAAAAATATTTATT +CATCAGTTTTATTAAGAAAAACGAAAAAAATCGATGAAAAACGAAAGAAA +ACAGGCGGAAAACAAAGCAAGATAAATGGCCGCTGAAACTTGTCGGCCCC +TCGGCCATGGCCTAGAAACCACTTTTCCTCGTCCCTCGTGAGGAAAAAGT +TGCAGTGAGAAAACTCAATTTTTGAATTTTTTTTTCATGAAAATCGGAAA +ATCTTCAATTTTTCCTAATCAATTCCATCTCTACAGAATCAAGAAATCTA +CACCCAATTCACATGTGCCACCGACACTAACAACATTCGATTCGTTTTCG +ATGCCGTCACCGACATTATCATTCGAGATAACCTCCGCACGTGCGGGCTC +TACTAAATTTTTCCGCTAAATTTTAAATTCCGTTTTTTCCCCCCAAAATC +CCCTCCCAGACATTTTCCGGTATTTATGTATTGACCACACACAACTCTTC +TCTCCCGTCTCCGCTGTTCAATGCTACGGTTATTCTCTTTTTTTTTCTTT +TTTTTTCCTGAAATTCCAAGGGTGTCGTTGAAAATCGAAAAATTCGAAAA +ATTTGGGTTTTTTAGAGGAAAAGCCAAAAATTCAATTTTTTTTTCGATTT +TTATTCCGGAAAATTCGAAAAATTTCGATATTTTTTAAATTTTTTACAAA +AAATTCGAAAAATTTGGATTTTTTCAGGAAAAAGCCAAAAAATTACAATT +TGTGTTTAAAAAAACGAAAAAAAAAACCAATTTTTCTGATTTTAATTCCG +GAAAAATCAAAAAATCTCGATTATTTTCAGAAAAATTCGAAAAATTTGGG +GCTTTTTCCAAAAAAGAAATCGTAAAATTTCGATTTTGTCCAGGAAAAAT +CGAAAATTTAATGTTTTCTTTTTTGGCTTCTTCCGGAAAATCCAAAAATT +TTGAATTTTTTGGATTTGTTTTCAGAAAAATTGGAAAAATTTGGATTTTT +CAGGAAAAAGCCTAACAATTTCAAATTTTGCTTTAAAAAAACTTTAAAAA +ATTGATTTTTGAGGAAAAAACGAAAAATTTCGACATTTTTTGATTTTTTT +TTTACCGAAAAAAAAATTGATTTTTTCCAGGAAAAAGCCAAAAATTTTCA +ATTTTTAAGGAAAAATTCGAACAATTTTGATTTATTGATTTTTTATTACG +GAAAAATCGAAAAATTTGGGTTTTTTAGAGTGAAAAGCCAAAAGTTCAAT +TTATTTTTCTGGAGAAATCCAATTATTTCAATTTTTGAATTTTTTCAAGA +AAAATAAAAAAATGTCGATTTTTTCCAGAAAAATCGAAATTTTTCGTTTT +TGAATGAAAAAAAATTTTTCCTTCAATTTTTCCTTTAAAAAAAATAAATA +AAAATGTTCGAATTTCCATGAAAAAAAGTCAAAAAAATTCAAAATTTTCC +ATTTTCCCTGACAAAAAAATCAAAATTTTCCGATTTTCCTAAACCAAAAT +CCCAAAATTTTCTGATTTTCCAATTTTCTCTGAAAAATCGAATTTTTTGC +CGCACACCCCTGGTTTCACGTGGTGGTCAGGTTGTCTCATTGCGGTTTGT +GATCTACAAAAAATGAGGGAATCTTTCCTCCCCCGGGAAAATCTGACGTC +AGCGCACTCGTGTAACCATGCGAAATCCTCTGCTGAAAAGTCTGCGTCTC +TTCTCCCGCATTTTTTGTAGATCAACGTGTAGATCAATCCAAAATGACAC +CTTGACACCACGTGCCTAAGCCCAAGCCTAAACCAATCCATTTTACCGGT +ATATCTCTACAACCTTTCACTGTCTGAAATATCGCGTCATTTTATATTAT +TATTATTATTGTATTCGCTTAAACGACAACAATTCCCCCATTTGATTCAA +AAAGTAAACATTTCCGAACTTTTTAAAAATTTGAAAAATATTTTTAAAAA +ATTTTAGCGTGAAAAACTTGTCCCCCCACCCTGCCTCTCCAAAAAAAATT +AATTTCGGAAGAATTCAGTCCTTGTTTTTGTAAATTGAGAACGTAATGCG +CTTTTTGGTGGTTTTTGCATATTTATCGACACTTGCGTACGCGAGGTATC +GATTCAGATTCCGTGAGTTTTTTACAACAAAATATCGCTAAGCAATCGCG +CTCCAGCGCGAAACTTCAAAAAAAGGCCAAAATTTTGCGTCGCTTTCTAT +GATTTTAAGACGAAAAGCGAGGAAAAATCAATAAAAACAGCGAAAACTTT +GAAATTTACGGGTTTGCCGCTTTTTTTGCGCTAGAGCGCGATTGCTCACT +GAGTTCAAGCGCCCTTCTTATTTTGAAATGGAAGAGTTTGCCGAATTAGG +CTATTTTGGTGCGGCCACGGCTGGGGTCAATTTACGGCGCGTTGCGTGCC +GCGTCGCGGTTAGGTGGACCACGCCTTTCCCACGCGTAGACGATTGTCAA +TAGAGCGCCGAAAATGCAAGGCCAGAAGCCCGTATGAGTGAAGTTTTTGT +TCATTTTCACTTTTTTTTCGTCGTTTTTAACGGTTTTTATGTGAAAATCA +ATAAAAACGGCGAAAATAATTAAAAATTTTCGATATTCCGGGTTTGGCGC +TTGCTTTGCGCTAGAGCGCGATTGGTCACCGAGTTCAAACGGCGCACTCT +GGCTTCCCTCTTAATTTGAAATGGAAGAGTTTGCCGAATTAGGCCATTTT +GGGTCGGCGGGTAGATTTACGGCGCGTCGCGTGTCGCCTCGCGGCTCGAT +TTTGATTGTAAAACTAAATGTATTTGTCCGTGTGGAGTACACGCGACTTT +CCCACGCGTTGTCCAGCAGGTTATTGCCAATGGAGCGCCGAAAATGCAAG +GCCAGAAGCCCGCCGTATAAGTAGCCCATATGAGTGAAGTTTTTGTACAT +TTTCACTTTTTGTTTCGTCGTTTTTATGGTTTTTATGTGAAAATCCACAG +TCTCCTCGTCATCGAAAGCGCACAAAAAACTGCTTACTGGCGCGTTTCGC +GTTTTTGCTAGCGCATTTTGTGGATTTCTCCGAAATTCAGAAATTACGCG +GAAAATAGGCTAGAATTCCAAAATTACAGCCCCGCCTCTTTTGATAATTA +TCTTCAGGATGAAGAAGATGATCGCGAAGGTGGGTGACTTGAAATATACA +AGAAAAATATGATTTCTTCAGAGAAACACCATTTTTACCGTTGATTTTTT +AATATCCCTACTCCTCCTTCAGTTTTTGACCAAATTTTCTCTTTTAATGG +TCTTTCATTTCATTTTGTGCTAATAAACAAATGTTAAGTTCGAAATCTGC +GAAAAAATTCGTTTCAACGCTAAAAAACGACGAAGTTTATTTTTCAACAC +TAAAAAGATTCACTCCCTCCCCCGGCTGTGCCAATGTGCAAGTGCGCCCC +AGCCCAATTCGACGCCGAGGAGACTGTGAAATCATTAAAAACAGTGAAAA +TAACGGAAAATTTCTGAAATTCCGGGTTTGCCGTTTTTTTTTGCGCTGGA +GCGCGATTGCTCACCGATTTCAAATAGCGCACGCGCTTCTGGTTTCCCCC +ATAAATTGAAATGGAAGAGTTTTCGCCGAACTAGGTCATTTTGGCGCGGC +CACGACCGGGGTAGATTTACGGCGCGCTACGTGTCGCGTCGCGGATCGAT +TTTAGTTGTAAAACTAAATGTAGTTGTCCGTGTGGAGTACACGACTCTCC +CGTCCGGCAGGCGATTGCCAATGGAGCGCGAAAATGCGAGGCCAGAAGCC +CGTGCATTTTTTTGCGGGTCCCGCCACGACATTTACCCTTTCAGACACGT +GTATCAAAGAGGACCAGGCGATTTTGGAGAAGGAAAATGTGAACTCGCCA +CGCCAATTTCTTTTTATCGATGACGGACAATCGCCAAAGTGGAGGGAAAA +TGATCTCGAAGGAAAAGGAATTCTTATGAGCTTCGGAAATCGATTGAAGA +ATCTGACAAACGGATATGAGACTGTGAGACTTTTTTTACGGGTCTCGACG +CGATTTCCCACGGATTTCGGGCTTCCCTCATAAATTGAAATGGAAGAGTT +TTTGCCGAACTAGGCCCCGGCCATATCTGGGGTAGATTTACGGCGCGTTG +CGTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAACTGAATGTATTTGTCC +GTGTGGAGTACACGGGCGATTGCCAATGGAGCGCGAAAAATTCAATTTGT +GTCTCGTAACGATTTTATCGATTCTTTTTCAGGGTGCCGAACAAGCTCTG +CGTGTCCTTGAATTCAACAATACGGAACACTTTCTTGTGATCAATTTTTG +GATGAGAAGCTACTATTTCATGAAAAACGGTGATAAATATCAGCTGTCAT +ACACCGGAACCACCATCAAACCCGATTTGAATCACTTTATTCGGTTAGCA +GGCTTGGAGATGCAATATCGCTCCATCGCAACCATTTTTTCAGCGTATAC +TTCATCTGCGCTCCAGCGAACAGTCAGAGTGCGTTGATCGTGTTTGGGGA +TCAGTCGAAACCGCGAGTTTTAAAGTCGAAAAAATCGAAGAGGGAAGCAG +CGCTGATTGATGAGAATTCGGGGAAGAAGCTGAAAAAGTGCCAGAAAATT +CGGACGAAAAGAGCGGCGGCGGTGAATAACTCGACGGAGTGGACACAGAC +GCTGAAGGATACTCGGAGACTTAAACAACGTAGCGAGTGAGTTTGTGCCA +AACGATACTCCGATGTTCCGCTTCCGCTGAGGACACCGCGTCGTTTGATC +TCTGAAAATTGCGAGAGTCAGCCTCGTGTAAGTTTACCGCAAATTTGGAG +GTCAAGCAGCGAGGTCCTCATATTTTGAAATGGAAGAGCTTGCCGAATTC +GGAGTCGATTTACGGCGCGTTGCGTTGCGTGTCGCGTCGCGGCTCGTGAT +TTTCGCATATTTATCGACACTTGCGTACGCCAGGTATCGATTCAGATTCC +GTGAGTTTTTGCAACAAAAAAATCGCTGAGCAATCGCGCTCCACTGGAAA +ACACCCGAAAAGTTTTGAAATTCCGGGGTTGCCGCTTGTTTTGCGCGCTA +GAGCGCGATTGCTCGCCGAGTTCAAACGGCGCTCTCTGGTTTCCCTCTTG +TACGAGACGAGCGTCGCGGTTCGGTCCAGCAGGCGATTGTCAATGGAGCG +CGAAAAACACGTGGTGTCAAAGTCTCCAATTATGGTTTGATCTTTGATAA +ATGCGGGAGACGAGAGACACCGACTTCTCAACTGATTTCGCATGGTTAAA +AGTGTTCTGACGTCACATTTTTCTGGAAGAAAAACTCCCGCATTTTTTGT +AAATCAAACCGGATTAGGACAGCCGGACACCACGTGGAAAAACAAGATGA +GGGAAGCCACAGAAGCCCGTGCAGAGTCTCGGTTTTATCAGTTTTCGAGT +AGTTTCGCACCACAAAAAGCGTGTGACGTCACATTTTTCCGGCCGCAAAA +TTCCCGCGTTTTTTGAAGATCAAACCGAAATGCATTGTTTCAGAATCTAC +TCTTGGGCACGTCTCTCGTTCATTCACCTCGGTTTCGGTATGGTAGTGAT +CGTCAACGCCATCGTTTTTTTGTTCTTTTTCAAGTATTTCAAGAAGTTCA +ACTCGACGGTGAAGAATGGAGATCAGAAGCAGGAATCGGATGAGACTGAT +GAGAAGACTGAGAAGACTGAGAAGCAGGCGAAATAGAACTTTTTAGTCTA +TCTGTGTTGAAATAAAGGAATTGAAAAAAAAAAAAAAAAAAATTTTTTTG +CATATATGCATGTGGTGTCAGAGTGGATTATTTCGGTTTGATCTACGTTG +ATCTACAAAAAATGCGGGAACTGATTTTGCATGGTTAAGAACGTGCTGAC +GTCACATATTTTTTGGGCGAAAATTCCGGCATTTTTTGTAGATCAAACCG +TGATGGGACGTCTGGCATCACGTGTACATGTAGAAATGAGATACAACATG +TTATGTACCGTTATCCTACAGTACTATAGGTGAACCCCTCAATTTTTGAC +CTCCAAAAATTGCGGGAATCTTATAGGTCAACTTGCAGGGGGTCGTGGAC +ATGAATAAGCCAAATTCAAATTATTCAAGCCAAAAAGATGATAGCGCAGA +CACGTGCCCCCAATTTCGGTTTGATCTACTGTGTAGATCTACAAAAAATG +CGGGATTTAGGACGCTGAGTTCTCCACTGATTTTGCAACAAATTCCCGCT +TTTTTGAAGATCAAACCGGACAACCTGACACCACGTGAAGGAATAAACCA +CGCTCTTTTGCCAAAATCTTAAGAGTTTCTACAATTTCAGTGAAAATCCA +GTATTAGATTTGATATTTGAAAAAAAAAAGTTAAATAATGGACGCGGCCT +AGTCTTTCCTCTTCTACTAGCAAAACGCCCTGTTTTACAAAAAAAATCTA +TAGTTTCTGAAAAAAAAATCAGTGGCAAATGTCTACAATTTTCAATATTT +CATACTAAAAAAATCACAAAAAATTATTTTATGGCCGCGGTCGAGTTTTT +TACTCTTCCACGTGGTTTCAGAGTGTCCAATTTCGGTTTGATCTACCGTG +TAGATCTACAAAAAATTCGGGAGTCGAGAACTGATTTTGCATGATTGCTG +ACGTCACATTGTTTTGGGTAAAAAATTCCCGCATTTTTTGTAGATCAAAC +CGGACAGCCTGGCACCGCGTGCGCAGAGAAGAAAAAGCTAATGAGCACGC +GGTGTCAGGCACGGCTTGATCTACAAAAATTGCGGGAATTTTCAACCCAA +AAATATGTGACGTCAGCGCGTGCTTAACCATGCAGAATCAGTTCTCAACT +CCCGCATTTTTTGTAGATCTACGTAGATCAAACCGAAATGGGACACTCTG +ACACCACGTGAATGAGCCAATTGAGCAAAAATCGTACTGAAAGAGATCGT +TTTATTCGCGCAGAGGTTAGTTACACGAATTGAATAGAAAAAATAATGTT +TTGCAAAAAAAAAGTAATGTACATACTCATGGAAATAAATTTATTATGGG +GGAGCTTGATTATTACAAGTCGACGAAGAGCAGCACTCCTTCTTCTCCTC +CTTTTCCTTCTCTTTTTCCTTTGGAAGCTGCGGAGAATTCGACTCGGATT +TCGACATTAGACGGGAGCTGGAGCATCTGAAAAAAAAACGCGAAAAATGG +TAGATCACACGTTTTCCAACCTATTACCTTCTCAAACTAAGACTGGAGAA +GAGCGGTGTACACTTGAGCATGTCCTTCAACTGTATCGACTCGTAGTTTT +CGATCGATTCCTGGAACTTTTCGATCCACAGCTCCTTGTCCGCCTTGTCG +GCGGCTTGTAGGGTGTAGATGCCGACGACTTGGTAGTAGCGGGTTAGGTG +AATTATGACGAACGCGAATTTTAGGGACACTGGAAGAGGAACACACTTAT +AGTGACACTACAGTAGTCCTAGAAGGTATTGGTAAGGTACTGGTAAGGTA +CTGACTGCGCTAATTTTTGTACGTTACACATTTTCCTGGAGTTTTGCAGA +CCTTCAAGAAAATTCTAGCACTTTCCAGATTTTCTCCGAAAAATTCCTGC +ACTTTCCAGATTTTTCCAGAGAATTCCTGCACTTTACAGATTTTTCTAGA +AAATTTTGTTTTTCTCAGAGTTTTTCCTATAACTACAGTAATCCTACAGT +ACCCCGACCATATCGCCCCTACCAACATACAACCCAATATTCCATCAAAA +GACAAAAACTCAAATTTTCCCGAACTACAGTAACCCTACAGTAACTCTAC +CGTATACCTACCGGGCCCCTACAGTACTGCTGCAGTACCTTGACATTATC +CCCTACCAACATACAACCCAATACCTCTTCGAAAGCTGGGAACTCAAATT +TTCTATAACTACAGTAATCCTACAGTACTTCTACAGTACCTCTACAGTAC +TACTACAGTACACCGACCATATCCCCCACTAACCCTAAACCAATATTCCT +TCAAAAGACAAAAACTCAAATTTTCCCAAACTACAGTAAGCCTACAGTAC +TCCTACAGTCCCCCGACCATATCCCCCTACCAACATACAGCCCAATATTC +CATCAAAAAACAGAAAAAACTCAAATTTTCCAAAACTACAGTAACCCTAC +AGTACTCCTACAGTACTCCTACAGTACCTCTACAGTACTCCTACAGTACC +TGGACATCATCCCTCACCAACTTCCAATCTAATACCTCTTCAAAAGCTGA +AAATTCAAATTTCCTATAACTACAGTAGTTCTACAGTACTCCTACACTAC +CTCTACAGTACCACTACAGTACCCCTACAGTACCCCGACCATATCCCCCC +ATTGACTCTAAACCAATATCCCTTCATAAGCACACTACAAAGACTACGTG +GACTACAAACTATGTATGGTCAGACGGATAGTTTTTTTTAATATAAGAAA +TGATGATGAACTATATATACTACTATATATACTGACACTGATTCACCAAA +ATTAGCGACTCTGGCAATTCACCAAAGATAGGGTACGGTACTGGTATGGT +ACTGGTACGATACTAGACCCCAGTTCTTTAATACGATTCCCTAAAATTGC +TCACTCGGCGTTGCCTGGTCGTTGGAGTCCGCATCACAGAACACGCAAGA +ATCCAACGGTACCGGCTGTCGTTGGACGATGTAGTGCTCGGATTTCCCGA +TTGGGACTCCTTTCTGCAACTCTTTCAGTAATAAAACAAGTAATAAAACT +TCGCGGGACTCCTCACCACTTTCAGCTTCGAAGCGCACTTTTTAGTTTTA +GTCAGCACAAACATGTCGTTGAATAGAAACGCGTACATATCAACGGTCCG +CCCGTTTTCCACAAGCTCGAGGGGGCCTTCGTGGATAAGCTTTCGACGCG +GATGAGCCAGAAGGTTCTCGCAGAATTGACGGGATAAGGCGACGCGGAGG +AACTGGAATTGTAAAAAATCAAGGGAAAATGTTGCAGAGAAAACAAATGT +TTCAACTTACATCAGGGACATAAGACTTGGGCTCCAAGTCGCTTATATTC +GGCCAGACAACCTGTGTCTGCAACTGCTGAAGCCTCTCAAAATTATGAAG +CCACTGCACACTATCATCAATCGATCGGAGTGATTCCGTCATTGTGTCGA +TCACCTTCTCCACCTTTCCCTTACTCTCCTCTTCCTCCGATCTTTTGTGA +ATCTCGCGGAGAAGGATCGGAAGCCGAGTGATTCGTTGAAGCGGTGCGAT +CAAAAGATCCTCGAGCTGTAGACGGAAGCATCGTTCATCGGCCAGACATA +TCCGCTCGAATTCCGTGAATCGTTCCTCTTTCTGTCGAATTGAGCCGAGA +TATTCCATGGTTGCCTTGTAGTTGATGCAGTAGGCTTGGTAGGCCGAAAT +TGTGGAGGGGCCTTTGGAGAACTGGAAGTTTAGAGTTATAACAAGGCATA +GTCTCAAGCTATTTTCCAGCCTATCCAAGCTGTGGTCCTGGTGCTTAACA +GTCTTGATTTTTTAGAGCTGGAAAACCGGACTAATCCGGACTACGGAAGC +CTGGTTTTTGTCTAAACGACAACATTGTGCAACAAGGTACGCTTTTTCAT +ACTACTTTTTTTTAAACTTTTGTTTTTTTTTGTTCTTTTTCGGCCAGCTT +TTAGGAACTTTTTTGACCCAACTTCGAAATGTCCCTTTTTTTTGCAATTT +TAGGAATTTCTAGAAATTTCCCATTTTCTCTTTTTCCAGCCCCTTCTAAA +CCTAGGCCTAGGCCTACGCATAAACCTAAGCCTACGCCTAAACCTAAGCC +TAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTA +AGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCTTAAGCCTGAGCCCAAG +CCTAAGCCTAGGCCTAAGACTAAGCCTATGCCTAAGTCCCAGCCTTAACC +CAAGCCTAGGGCTAGTTGAAAGCCTAAGCCTAACCCAAACCCTAAGCCTA +AGCCTAAGCCTAAGTCCAAACTTAGGCCTAAGCATATGTCTAAGCCTAAG +CCGAAAATGTCCCTTTTTTTTGCAATTTTAGGAATTTCTAGAAATTTCCC +ATTTTCTCTTTTTCCAGCCCCTTCTAAACCTAGGCCTAGGCCTACGCATA +AACCTAAGCCTACGCCTAAACCTAAGCCTAAGCCTAAGCCTAAGCCTAAG +CCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCT +TAAGCCTGAGCCCAAGCCTAAGCCTAGGCCTAAGACTAAGCCTATGCCTA +AGTCCCAGCCTTAACCCAAGCCTAGGGCTAGTTGAAAGCCTAAGCCTAAC +CCAAACCCTAAGCCTAAGCCTAAGCCTAAGTCTAAACTTAGGCCTAAGCA +TATGTCTAAGCCTAAGTCTAAACCGTAGCCTAAGCCGAATCCCAAGCCTA +AGCCTAAGCCTAAGCCGACGGAGCACGAGGAGAAAGTCCAAAACTTCACA +AAAAAACAAACATTTCTCTCAATCTCGGTCAGTTTTCAAAAATATTTCGA +GTAATTTTTCAGCACAAATAACAAAAACCCACCCTTTCAAACAAGTCCAC +AACTAGCTGTGTGCAGTCCCAATTCTCCTTGTCTACCGTACTGAGCAACG +AGAGGAACGATTGACAGAAGGTTCGAGATATTCTGACAAAATAAAAATGT +GTGTGTGTGTGTGAAATGGCACGTCAGATTAAAGGCAAATAGAAAAAAAA +AACCAATTAAAAACTGAACGAACCTGCAGAGTTGATCCAAATTTCCGAAA +AGGAGGTCCGGCTCGACAAGCAGTAGACATCCCTCGACTTGACATCTCTT +CAGCGGCTCCTTGTAAACATCGCGGAGCACGAAGAGCTGACGATAGAGGA +AGACGAGCTCCGTGTGGAACAGCTCCCATACCGCTTGAAGGTATTTGTGT +TTGGATGAGGGAATTGTCGTGGTCTCGTCTCCCATGAACATTTCCTCAAA +GGATACTGGCTGAAAGTTGGATTTTTTTTTGGTATTGGAGCTCGTCTCTG +GGCTCGTTTTGCAGTTTGTACCCTTAAAAAGACATTAAAAAGACATCAGC +AACAAACTCCAAAATCCCAAGTAGTAAACAGATTTTTTCTAAAACGGCAA +AATTGAGTGAGGAATTTTTATTCGATGCACCATGTTTCTCACTCAAATTT +GACTACTCATAACTTAGTTAAACCTAATCCAATACTTCCTTAAAAGCTAA +AAATTCACATATTCCCAAACTACAGTAAACTACAGTACCCTACCGTACCC +CTACAGTACCCCGACAGTACCCCTACAGTACTTTGACAATATCCCCCATC +AACTCCCTACAAAATCATCAAAAACAAAAAATTCACAATTTTCAAATCTA +CAGTAACCCTAGAGTGATCCTACAGTATTCCTACAGTACCACTACATTAC +CTTGACATATCCCCCACCAATTTCCAACCAAATACCTCTTCAAAAACTAA +AATTCACATTTTCCAAAACTACAGTAACCCTACCGTATACCTGCAGTACC +ACTACAGTACCATTAAAGTACCTTGACATTATCCCCCACCAACTTCCAAT +TAAATACCCCTTCAAAAGCTAAAAATTCAAATTTTCCCGAACTACAGTAA +CCCTACCGTATATCTACAGTACCCCTACAGTGCCACTACAGTACCTTGAC +ATTATCCCCCACCAACTTCCAACCCAATACTCAATCAAAAGCTAAAAATT +AACATTTTCCCAAACTACAGTAACCCTACCGTATTCCTACAGTACCCCTA +TAGTTTCACCTACCAACAACTTTTCCAGCTCATCATCCTCAATCTCATGA +TCCTTAGAAGTCTCCAACGCGGCCTGCACATGCTTAATAATCTCCCTCCG +TTTTGCTCTGCCCGACCACTCGTAAAGTCTCTTCAGAATCCAGGGCGATC +GATTTTTCTGCGGCTCGGAAGCTTCTGCATAGAAGGCTTGAGAGGCTATT +GTGGCACGTTGAAGATCTGAAAATGAAGAATCGGTGGGGATCAGTGGTGA +CAGCGAGGGAGAAGATCTATTTGGTGGGGTGGCACATATAGAAGTGGGTA +GTAGCGGTTTTTTGTGTGATCTTTGTGTAAATAGACATGATATTAGGGCT +TCCGTGGTAGGCAGGTGCGGTTTTAGGGCCTGGCGCTTGCCTGACGCCTG +CCCGTCTCACGCCTGCCTGGCGCCTTTTATTCTGCATTTTGAAGTGAGTT +TTCAAATTTCAAATTTTCTCATTTTTATCATTTTGTTGAAAATCAAATTA +AGAAATGAAAAAAAGTTTAAGTAGGTTTCAGCATCAGGCGTGTATTTAGG +CGAGAGGCAGGCGGGGGTCGCCTCAAAGTCAGGCAGGCAGGCCTTCTTAT +GCCTACACGGAAGGTGTTCAAAAATCGGTTGCGTGTGTCCAGTAATGACA +AGAATCATACAAAGCATTCGACTTTTACACAAAACTAGTCTGTATTCCAC +CTGTACAAAAACCTACCGATCGATGTGATTTTATTTGAATCTGAAAAAAA +AATTTCTCAGAAAATTTGAATTCCCGCCAAAATGTTTCTTTGAAAGTTTG +AATTCCCGCCAAAAACATTCTCAGAAAATTCAAGTTCCCGCCAAAAATGT +TTCTTTGAAAATTTGAATTCCCGCCAAAATTTTTCTTTGAAAATTTGAAC +TCTCGCCAAAATGTTTTTTTTTTGAAAATTTGAATTCCGATAAAAAACTT +TTTACAGAGAATTTGAATTTCCCCCTACAATTTTCACAGATCTACTTATA +TATATATATATATATATATATATAAGTTGAACTTTAGTTTTCAAAAAAAA +ACCGGTCATTTATTAAAGCACGTGGTGTCAAAAAATATTTTTTCGGCTTG +ATCTACGCCGATCTACAAAAAATGCGGGAGAAAAGACGCAGAGTTCTCAG +TTGATTTCTCATGGTTAAGAAAATTCCCGCATTTTTTTGTAGATCAAACC +GTAATGGGACAGCCTGGCACCACGTGCTAAAGTTATAGTTAATTTACAAG +TCCTGGTTGGACCTGCAGGATGTCAGGCGCTGAAACGTGTTTCAGGATAA +AGTTGGTAAACTTTTATAACCAAGAGGAAAGTGTTATCGATATTTTGCTA +GTTGAACATTTTTTTTTGCTAAAAAGTAAGAGTATTTGAGCCAGGCGTGC +GCGGCGATCGGTAATTTCCGAAAATCGGCAATTTCGGCAATTGCCGGTTT +TGTGAATTTTTGGCAATCGGCAATTTTGGCAATTGCCGAAATTGCCAAAA +ATTCGATTCCGCACACTCCTGCTTTGAACTGTGCATTTCCAAAATCCAAT +AGAAATTCTGCCGACACTGTAAAATCCCTACCTGCCAACAATCCTCCGCC +GGAGCTGATTGCCCTATTGAACAGGTGACTCTCGTTAGGGGATATTTGAA +CATGTGGGACAATGATCACATTGTCCGACGAGCAGCACCCTTGGGATGAG +GTCTCCTGATTCTCACTTGGCTGATCAGGAATGATTGCATGGCGACGGGA +AAGTTGCTCCTTGTTAGGGTGAATTGTTTGGGGCTCTCCTTCTTCTGGCT +GGAAAAATACAATTTTTTGAAGTTTTTGAAAGAAAGCTTGTCATTTTTTT +GTTGCTATTTTTTACCCTAAAAATGTGGTTTCAAAATTTTTTTACCTCTG +AATATCTAATCAACGGGGTGAACAACTGCAGATCGACCATACTCGAGCTT +CTAAAAGTTTGAAGGAAGCTTCTCGTGAAGCACGAAAAAAAAAGAAACAC +GAAATAGTTACCCTTACAATTATCAGAATAGGATGGGATGTACAGAGAAG +TAAATAGGAAGAGAAATGAGAAGAGTTGCACTAGAGAAGTATGTACAATT +AATAATTTATGAGCATCTGAGAAAATGAGAGCGACTTGAAAATCTGAAGA +GCAAGGAAGATAAAACTCGGTCTCTTATCAGAAAATTTGAATTCCCGCCA +AAATGTTTATTGTTTAATTTGAACTCCCGCCAAAACTTTTCACAACGAAT +TTGAATTTTTCGCCAAAATTTTTCTCAGAGATTTTGAATTTTCCCGCCAA +AAGTTTTACCAGAAAATTAAAATTCCCGCCAAAACTTTTCACATCGAATT +TGAATAACCCGGCAATTTTTTTATCAGAAAGTTTGAAATCCCGCCAAAAT +TTTTCACATGAAATTTGAATCTTTCGCCAAAGATTAAAATCGTTGGATAA +TTTTAATTCGCGGCTGAACGTTTCCAATTCGAATTAAGACCGGCCAAAGT +TTTTCGGGGTTTTTTTTAAAACTTACTACAAAAAAGCATACATTTATTTT +CCTAACTAGACGCCTTACTAGGTAAAACCCGCTTTTCACATCAAAAACTT +CAACAATGCGTCACCGCCAAAAGAGATTCTTGCACTTCACCACGAATAAT +AGATCAGAAGGAAAAGCGTGTAGTGAGTTGAGAATTATAACTAATTCATA +TCCCCCGAAAAAAAAAACGCTGATGTCTATATTCTATACATGGTGAGAGC +TCACCGAAGAATAGACGGGTAATGAGATATATATGTGATACATAAATGTG +TGCGCCCGGGTATCCGAGAGCCGAAAACAGAAGCATGGAATGGAGCAACT +AGGGAAAATTGTGTTATCACGAGGCACGGCGGGAGACACAATAATATGAT +TTTTTTTCGAAAATTTTCCATTTTCACGTGGTTGTCCCATTACGATTTGA +TCTACCAAAAACGCGGGAATTTTTCGCCTAAAAAAATGTAACGTCAGCAC +GTTGTTTACCATGAGAAATCAGTTGAGAAATTAGCGTCTCTTCTCCCGCA +TTTTTTGTAGATCTAACTTGATCAAGCCGAAATGAGACGCTCTGACACCA +CGTGACGAAAAAAAGTAGATCAAAATTTGGCAAGCCCTTATAAAAGTCCC +TTTTTCAGTTCTAGGCGGAGCTCAGTTTGACTGATGACGTAAACGCAAAT +CTTGAAATTTCGAATTCTCTATGGAAATTAGAACTTCCCGCCGCCGCCAG +ACTTTGTAAAGTTCAACAAAAAGATGAAATATAGAAAAAGTTCAGACTAT +GATAAGGAACTTATGACTAACGTCTCTTGAGGTGAATGAGTATGATGTGA +TTAGTGATGCAAGACGACTAGACCGAGAGAGAGAGAGAGAGAGGCTCAGA +GAGGGGGGAGGGAAGGTAGGTTTGTAGGTAGGCAAGCAGGTAGGCAAATA +GGGGGTCGTAAGTAGAAATTATGAAGGAACCTAGGTCGGCAGCCATAAGG +TAGGCATAAAGTAGGTCAGCATCCAAGTAAGTTAGACAGGTACGCATAAG +ATAGGAAGGTAAGTAGGCGCGGTGGCAAGGAGACTCAAGGCAAAGTAGGA +CAGGAAGTAGGCAGTAGGTAGGCACGATGAAGGTAGGTGGGTAAGCTTGT +AAGAAGGCAGCCATAAAGTATGAACGTCGACAGTAGGCATGCATTTAGTA +GGTAGGTATGAAATAAGAATTAAGGTATGCATAAGGAAGTAAAGTATGAA +TGATGAAGCCATGTAGATACAGAAATATCAGGCAAGTAGACAGGCAGGCA +TAATATAGGAAAGTTAGCAGTAGGTAAGCATGTAGTAGGTACGTGGGTAG +GCATGTAGGTAGGCACGTGGTAGGCTTATGGTAAGCAGAACACAAGCACA +GAAATATGCATATTGGCAAGTATGTAGGCATGCATAAGATACAAAAGTCG +ACCAGGCATGTAAGTAGGCACATAGGTAGGCAGGCTTGAGGCAGCAATGT +AGGTGATCTCGTAAGTAGGTATGAGTAAGGAACCTAGGTAAGTCACAGGT +ATTTGGCACAACCTGTGTTCTTCTCAATGGTAATCAGGCGAACGTGCCTG +CCTGCCTACCTAGAAATTCGGTAAAAATTGTGGAAAAAAAACTAGGGGAA +CCTCTTCCCAATGGAATGCGTAATGTGAGTGGGAGGCGGCAAAAAAAGAG +CGGACGTAAACACTTTTTCCTAATTCTCTTTTTCTCTCGCTCGTGGAAAA +TGAATGAATATTTGATACAATTTTGTGGGTACAGCCAGCAGGAGAAGAAG +AAGCTGATGTCCCGACGCGCGCGCGCGAAAAAAACTTTCAATTCCCTCCC +CTAATTATCCGCCTAACGCCTAATGTGTGTCAAATTTACCATGTATTTTT +TTCTCCTCTCGGCTATGTTTTTTTTTCTTTTTCAGCAAAAAAAAGTACGG +GCACATGAGGTCGGGATGGATAATTAGGGATGTGTGCCAATTTGTTGGAT +AATAGACAAAAAAAGTACGTGAGATTTTTAGAAAATGCTGAGAAAAATAT +CACGAGGCGTTGGGGACGTGGCCGCGAATGAGAAAACTAGGCCACCTTCA +CAGGGCCCTGGCCTTCCTCATTGAACTTTTCGCGCTCTACTGACAAACGC +CCGTGTACTCCACACGGACAAATGCATTTAGTTTTGCAGCTAGAATCGAT +CAGCGACGCGACACGCAACGCGCCGTAAATCTACCCCAGATATGGCCGAG +CCAAAATGGCCTTGTTCGGCAAACTCTTCCATTTCAAATTTTTTATTCAG +TTTAATTTTCTAGGATACGCCTACGAGTGATCTAGGCCAGGCAGTAGGTA +GGCAGCCAGTGTAGGTAGCCCCCTTTTGGTGTCAGGCTGTCCCATCGCGG +TTTGATCTATCAAAAATATGGGAACTTTTCTCCCAGTAAAATGTGACGTC +AGCACGTTCTTAATCAGGCGAAATCAGTTGAAAAGTCTGCGTCTCCTCTC +CCGCATTTTTTGTAGATCAACGTAGATAAATACGAAATCAGACACTCACG +TGGTGCCAGGCTGTCCCATCGCGGTTTGATCTACAAAAAATGCGGGAACT +TGTGCCCAAAATTATGAGACGTCAGCACGTTCTTAATCAGGCGAAATCAG +TTGAAAAGTCTGCGTCTCTTCTCCCGCATTTTTTGTAGATCAAAGTAGAT +CAATCCACATTAAGACCTTCTGACACCATGCCCGAGAAGAGTTCAAAATA +AATTTCGTAGAACATAAATTTTTCCACGTGGATTTTACAGCACAATTGCT +TATAGAGCGCGGTTGCACCCCAAATTTTACAGGAAAAATAGGAAAATTTT +ACCAGATTTCCCGCGCAAGACACGAAACAAGGTCTTAAAAAGTGGGAGAG +CATGAAAAATCCTAAGAAAGTAAGAAACTTCTGGTTTACCACATAACTCA +AATTGGAGATAGTTCGACCTTAAAAATTTTGCACCAAAAAGGGCGGAGCC +AAAAACACCAAAACTTACGTGCAAATTTGTACATGAAAAAACTAAAAAGG +ACACCTAAAACCGGCGAAATATGAAGAAAAACGCTGAAAATGAGCAATGT +GTATCAATTTTTCCCCCGTTGCTTAATTTAATACATGTCTTCCTCTCCCC +CTTCCTTCCTGCTTCACACTCTTTCGGGCGGCGCCTCCTTTTGATTTGAG +ACTTGAGACTTTTTTTTTTGTGATGTGCGTTGAGTAGTGTGGGATGCATA +TATTATGAATCAAAAATCTGACATCAAAAATATCGCTGAAAAAATAGTTA +AAATTTGCTTTAAAACTGCCGTTTTTGATCTACAGGGTGCTTTGGCGCGT +TGCGGTCGCGTCGCGGCTTGGAGTTCTAGGCCACGGCCATTCAATTTGAC +ACTACTACAATCAGAAATATTTTGTAATTCTTAGGCCATCAAAAAATTTT +TAAGCCAGAAAACAAATCCGGAAATTTCTAGGCCATCAAGAATTTCTAGG +CCACATCAGACTACTTTGAAAATTTCTAGGCCACAATGGGAACTAATTTC +TGAACCTAATTTCTGAAATTTCTTGGCCACGATCTGAAATTTCGAAGCCA +TAATTTGAAATTTCTAGGCCACGATCTGAAATTTCTAGACCATCAACAAT +TTCTAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAATTTGTAGGT +CAAGGTTTGAAATTTCTAAGCCACGATTTGAAATTTCTAGGCCACGATCT +GAAATTTTTAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAATTTT +TAGGCCACGATCTGAAGTTTTTAGGTCATCAAAAATTTCTAGGCCACGAT +TTGAAATTTCTAGGCCACGATCTGAAATTTCTAGGCCACGATTTGAAATT +TCTAGGCCACGATTTGAAATTTTTAGGCCACGATCTGAAATTTCTAGGCC +ATCAAAAATTTATAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAA +TTTCTGGGCCACGATCTGAAATTTCTAGGTCATCAAAAATTTCTAGGCCA +CGATTTGAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCGCGATCTGA +AATTTCTAAGCCATCAAAAATTTCTAGGCCACGATTTGAAATTTCTAGGC +CGCGATCTGAAATTTCTAAGCCATCAAAAATTTCTAGGCCACGTTTTAAA +ATTTTTAAAATGTTTAAAATTATAGGTTTTCAAAAAAATTCTAGGCCATC +AAAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCACGATCTGAAATTT +CTAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAATTTTTAGACCA +CGATCTGAAATTTCTAGGCCATCAAAAATTTATAGGCCACGATTTGAAAT +TTCTAGGCCACGATTTGAAATTTCTGGGCCACGATCTGAAATTTCTAGGT +CATCAAAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAA +ATTTCTAGGCCGCGATCTGAAATTTCTAAGCCATCAAAAATTTCTAGGCC +ACGTTTTAAAATTTTTAAAATGTTTAAAATTATAGGTTTTCAAAAAAATT +CTAGGCCATCAAAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCACGA +TCTGAACTTTCTAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAAT +TTTTAGGCCACGATCTGAAATTTCTAGGCCATCAAAAATTTATAGGCCAC +GATTTGAAATTTCTAGGCCACGATTTGAAATTTTTAGGCCACGATCTGAA +ATTTCTAGGTCATCAAAAATTTATAGGCCACGATTTGAAATTTCTAGGCC +ACGATTTGAAATTTCTAGGCCACGATTTGAAATTTCTGGGCCACGATCTG +AAATTTCTAGGTCATCAAAAATTTCTAGGCCACGATTTGAAATTTCTAGG +CCGCGATTTGAAATTTCTAGGCCGCGATCTGAAATTTCTAAGCCATCAAA +AATTTCTAGGCCACGTTTTAAAATTTTTAAAATGTTCAAAATTATAGGTT +TTCAAAAAAATTCTAGGCCATCAAAAATTTCTAGGCCACGATTTGAAATT +TCTAGGCCACGATTTGAAATTTTTAGGCCACGATCTGAAATTTCTAGGCC +ATCAAAAATTTATAGGCCACGATTTGAAATTTCTAGGCCACGATTTGAAA +TTTCTGGGCCACGATCTGAAATTTATAGGTCATCAAAAATTTCTAGGCCA +CGATTTGAAATTTCTAGGCCACGATTTGAAATTTCTAGGCCGCGATCTGA +AATTTCTAAGCCATCAAAAATTTCTAGGCCACGATTTGAAATTTCTAGGC +CACGATTTGAAATTTCTAGGTCACGATTTGAAATTTCTAGGCCACGATTT +GAAATTTATAGGCCGTGATCTGAAAGTTCTAGGTCATCAAAAATTTCTAG +GCCACGATTTAAAATTTCTAGTCCATCAATAATTTCTAGGCCACCAGAAA +ATTTGTGTTCACTTTTTTTTTTGGTTTTTGGTATGTATTTTTCAGAAATT +ATTCAAAATTTGTGGGAGCAACAATATGCTTTTTTAGTTTCTAGGCCACA +AAATTCTTTGGCCATTTTCACATTTTTTCCCGCCGCCAATGGTTCCACTG +GATAATTGAATGTATAGAAAAAAGGGAAGAGTTCAGCTGGCGCAAAAGAG +GGTAATTCGTTGGAAGGGAAAAAAATAAATGCAAATCTTCGCCAAAAACC +AATTTTCGGTCGGAGCTCGGCGCGGGCCGACACACACAAAAATGGAGCAG +AAGAAGACGTCAGAATCTTCTTTTTCAGAAGGCTTTCTCACTTTGAAAAT +GGGGTGTCCAATTTCTTGTTGCTAATTGTTGGATGGGGAAAGAATGATAT +TTTGTTTCAGGTTTCACACAACATCAGCCTAGACATTTTTTTTTTGTTTT +CTCCAAGAGGAGTACACACACTATAAATTGTTGTAAAAATCGAAAAACAC +GTGGAGCCAGAATTTCTTATTTCGATTTGATCTACAAAAAATGCGGGAGT +TAAAACGCAGACATCTCACCTGATTTCGCAAGAGCGTGCTGACGTCACAA +TTTTTTTGGAAAAATATTTCCGCATTTTTTGTAGATCAAACTGCAATAAG +ACAGCCTGGCACCACGTGAAAAATAGTATTCCTCTTGAAAAAGATTTCCC +GAATCAAGTTCCTTGAAAGGAGTACGCAAAATTTTGCAAAAAAAATCGGT +GGCCGAGTTTACTCTTCTGGCGGCCACGTAACAAAATTAACAAGGAAGGA +TAAAAAGGAAAAAAAAATTTTACTCGTAAAAAGGTACCAGGAAGCAATTT +GAGGAAGGAAGGAAATGTGAGTGTCTACTCTAATGATCTACCAGTTTTGG +TGGCCGCGGAACAGAGAAAGCTCGGCCCCCAAGTATTTTTTCAAATATCA +CGGATTTCTGGTTTCCCTTATAAGTTGAAATGGAAGAGTTTTTAAAGAAC +GAACTAGGCCATTTTAGCTCGGCTGGGGCAGATTCACGGCGCGTTGCGTG +TCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAAATATATTTGTCCGTGT +GGAGTACACGACTTTCCCACGAGTTTTCCGACAGGCGATTGTCAATGGAG +CGCGAAAAATTCAATGAGGAAGGCCAGAAACCCGTGAGATATTTAAAAAA +TATTCCAAAACTATTTTTATATTCAAAATTGGAAATTATACATACTATAA +GTATTTTCAACTACATACATGGCCGCGAAAAAAAAAAACTCGGCCACCAA +TTTTCGCGGTCACTTACCGCAGATCTCCATCGATCCTGAAGTCTTGCCGT +ATACAATAAGGGCATTTTTCGGATCATAGTGAATGAATTATTTCAGGAAT +ATTATTTCAAAGAACACACACCACACAAGAAATGTGAAGGGAAGGAAACG +GGGAAAAAGAGACAGGTGGAAAAATACATTTTCTCTATTATTTCGCTCTG +TTTCTGACTAGGAAATGAATCAGAATCAGTGATTAAGAAACTGGGAATTT +ACGAGGTGTTTAGGGAGATGGTGACCGCGAGGATGAGGAAAAACTCGGCC +ACCGCAAGACTTACCGGCTTAATCAATTGATTTCCTCGTATGTGATGGAA +CAATGTGAGAGCCGGAGCTTCACTCGTCATAGCTTTGTGTCTAGGTGGCT +CTCAAGTACTGCTGGACCTGAAAAACTGCAAATTTAATTTGAAATTTGGG +ATGCAAAAAAGTAGCAGCCGACACCTGCCGGGTTCCCGCAAGATGTCGGA +TGCTTCAATTGACCTAGTAGAATCGTTAGTGATCTACCGAGCAAAAACAA +GTATGCTTGCAAGAAAAAAAGGCGTGTGGCTCAAGTTGACAAATTCGACA +CTTTGGACACACGAAATTGGATGAGCCACACCACACCGGCTAGCTCAGAA +GAGCCCCTCCGACGTCAAGGACCCCATGTGCGCGCGCGAGCCGAGATTCT +GGCAACATGAGAAGCGGAGAAGGCGAAGAGAAGAGTGCTAATTTGAACTT +GTTGCTGCAGGAAAAATATCTAGGCTTAGGCTTAAGCTTGGGCTTAGGCT +TAGACTTATGCTCAGGCTTAGGCTTAGGATCAGGCTTAGGCTCAGGCTTA +GGCTCAGGCTTAGGCTCAGGCTTAGGCTCAGGCTTAGGCTCAGGCTTAGA +ATTGGGCTTCGGCTTCGGCTTTGGCTTGGCTTAAGCTTAGGCTTAGGCTC +AGGCTTAGAATTGGGCTTAGGCTCAGGCTTAGAATTGGGCTTAGGCTCAG +GCTTAGAATTGGGCTTAGGCTTTGGCGTAGGCTCAGGCTTAAGCTCAGCC +TTAGGCTTTGGCGTAGGCTTAGGCGTAGGCTTAGATTTAGGTTTAGGCTT +AGGCCTTGGCCTAGGCACAGGCCAAGGTTTCAGGTCACTATCACTTGCTC +CTAGGTGTGGCTGGGGAAATGAAATTCTAGGCCAGTGACGTCAAGATTCT +GGAAGAGTTCCGTTGACGCCACCAAAAGCAACAAAAACTTCAAATCTGAG +AAGATCAGAACAAAATGTACTGAAAGTACAAAAAGCCCGCACTTTTTTCT +CTATTAATACTACTCATTTGAAGAGTGGGGAAAAGAAAAATGTGTTGCAA +GAAATAATTCCGTGCGAAAAAAGTTTGAGAGGAATGAATGGAGCGGAACT +TTTTTTTTTGTTGGAAAATCGTAGGTGTGACGTCACTTCTCTTCCAACCC +CCAGGTTTCTAGGCCACTTAAGAATTTTGCAAAAAAATCACAGAGCAAAA +CTACAAAAAGGAAAGAAGAAATGTGCTCTTGGAAAATAATAAATATTGGT +TACGAAATAAAAGAGAAAAGAGAACGAAAAAAATAAAAAAGAAAATGGTA +ACCAAGGAGGAATGTGGAGAAGAGGCTCTTGTGAGCCCAGATATACCCAG +CAATTAGGGAGCGAGTACTACTGCCGGGAGATGACGTTTCGAGGATATTT +CTCACTGGAATGGAGGGTGGTGGAAGAGTTTTGTAAAGTTCTAGGCCACG +GGTTTTTTTGGCCAATGAGCATGGTGCATCGATGAAAAGCTATTGGGTTT +CTCGGCCACAATAAATTACAAAAACCTAGTACGATGGAGCACACTTGCAA +TAGAATTGCAAAAATTTATTTGAAAATTGAGAAGAAAGAAAATCAGGGGG +GCATAAATGCTCAACAGTGCAATCAAATTGTAGAAGAGCTTTCGCCCAAA +AAGCTAGGCCACGGAGGAGACCGCTGGAGAAAGTGACGTGTATATGGTGG +AAGAGTTTTCTTGTTTTTCTAGGCAATCTTGGGCGATTGCAAAAATTGAA +TTTATGAAAAGATGGCTTGGAAGAGCTTTCGCATAGAAAATCTAGGCCAC +GGCTAGCAATTTAATAGGGGATAGAAAACCGCGTCGGAAGATTATTTAAC +TTTTCCATAAAAATTAGCAAATTTAAGAGAGTTCAGATACTGATCTGGAA +GAGTTTTTGAGCAAAAAACCTTGGTCACGGCCAGCAACTAAAGTAGTAGG +GGAGATAGGGTACCCCGCTAATTTTTTATTTATTTTTCAAAGAAAGTTTT +AAGGTTTCGGGAAAAATTTTGATGAAATGGCTTGGAAGAGCTTTTGCCGA +AAAAACTTAGGCCACGGCCAGCAATCTAATGAGAGGGGGAGGGTTCCCCG +CTAAATTTTTTTTTTGATTTTTAAACAAAGTTTCATGGGTTCGGGGGAAA +ATTTGATTAATTGACTTGGAAGAGTTTTTAAGCAAAAAAAAACCTAGGCC +ACGGCCAGCACCCTAATGAGAGGGGGGAACATAAGGTACCCCGCTATTTT +TTTTTGATTTTTCAAAGAAAGTTTTAAGGTTTTGGAGGAAATTTGATTAC +ATGACTTGGAAGAGCTTTTGCAGAAAAAAACTTAGGCCACGGCCAGCAAC +CTAAAGTAGTATGGGAGATAGGGTACCCCGCGGAAAATTTTTAAATTTTG +GTAAACAACAATGGAAGAATTTTCCGGTTTTCTAAGCCATTGCATTTTTT +CAGCGTCACGGATTTCTGGCTTCCCTCATAAATTGAAATGGAAGAATTTG +CCGAACTAGGCCATATCTGGGGTAGATTTACGGTGCGTTGCGTGTCGCGT +CGCGGCTCGATTTTAGTTGCAAAACTAAATGTATTTGTCCGTGTGGAGTA +CACGACTTTCCCAGGAAGGTGATTGTCAATGAAGCGCAAAAAATTCTCAA +AAAAAATCCAGATTCCCGTGCAGCGTCGCAGGAGATCATTTTCAAGAAAT +CTGGCTCAAGAAGGATTCAGTAAAACAAGAAAAGAAATAAAAAAGGAATG +AAAGGTAAGGGTGGACAAGTCGGCGGGACAACTTGTCACTTGCCATCATC +ATCATTTTTCTTCTCCTCCTCATCAGCTTCTGCTGCTCCGCGAGCTCGCG +ATGACTCTTCTGAAATTCTAAACTTGGCCAACACAACGTCGGCAACGAGT +TTCGAATTTACACACACACACACATACGAAAAAAGCTCATTAATTGGAGC +AGGAGACGGAAGAGAGGGAGGAGAGGCTGCTCAATGAGTTAGAGAAGAGA +GAGAGAGAGAGAGACTGAAAGATGAAGTATAAGCAGAAGTCGTCGGGATG +ACAGAAGAAGGAGGAGAAGAAAACGTGAGAAGGGGGGATGTGGAGACAGA +AGGATATGTAAATATATTAGATTCAAGGATTACAGCAATTTTAAGGAGGC +AAAAAAAAACAACGATGCTCCGATATTTTTGGGGTTACTGTAGTTTTTGT +AGATACTTCCAGAAGTTATAAACAAATCCGAGTTTTTTAAAATTTGCCAG +AAGCACGGGTTCATTGAATTTTTCACGCTCCATTGACAATCGCCTGCCGG +ACAACGCGTGGGAAAGTCGTGTACTCCGCACGGACAAATACATTTAGTTT +TACAACTAAAATCGAGCCGCGACGCGACACGCAACGCGTCGTAAATCTAC +ATATATGGCCGAGCCAAAATGGCCTAGTTCGGCAAAAACTCTTCCATTTC +AATTTATGATGGAAGCCAGAAATCCGTGCAGAAGTTTCTCGGAAAAAAAA +CAGAAAGTTTGCGAAATGGCAACCTCTAATTCATTAACATAAATACATCA +AATATGACGCGCAAAAATGAATTAATTTACTAGTGAAACATGGTGCATTG +AAGTCGGTGTTTGCACAATTTGTACAGATCTGAGGTTCACTAACACCAAT +GCACGGCCCGAGAAGTGGTACCTGTACGCAATTTGTCTACCGTATACCTG +GACGTTTGGGCGCGTGTATCTCAAAAACGGTTGGTCCAGTTTTTTTGTGA +TGCATATAAAAAATGTCCGAAATTAAATTCTAAATTTTTTGGACCAAAGC +TTTTTTCGTTATCACGCGCCCAAACCTGGTCTACACTCAAATTATCAGTA +GAGCGCATTTGCATGGATGTACCACTTGCCGGGCCGTGTTCAAAGGGGTG +CAACGATTGCGCGTCAAATCGAATGCAACTACAGTAATCCCTAGTAGTTG +CGCTTCAAATTTGATGCATTGCACGGCCCGGCAAGTGGTACATCCATGCA +AATGCGCTCTACTGATAATTTGAGTGTAGACCAGGTTTGGGCGCGTGATA +ACGAAAAAAGCTTTGGTCCAAAAAATTTAGAATTTAATTTCGGACATTTT +TTATATGCATCACAAAAAAACTGGACCAACCGTTTTTGAGATACACGCGC +CCAAACGTCCAGGTATACGGTAGACAAATTGCGTACAGGTACCACTTCTC +GGGCCGTGTTGAATGTTTGAGAAATGTTAAAATTTTGAGTTATATGTGCT +GGAAAATTGACATGAACATGGTTTTTTTCATTATTTGCGCGTGAATTATG +GTGCATTGAAGTCGGTGTTTGCACAATTTTTTTCAGATCTGAGGTCAACT +GACACCAAAGCAACAGAGTTGACGCGCAAATTTTAAAATGCGCTTAACAT +TTGGCACGCTTTGCAGTCGGTGTTTGCACATTTTCGATTGTTGTGTGAGG +TTCACCGACACACCAGATTTGACGCGCAAAATTGTACGAAAACAGTTAGT +TAGAAAACTAATAAAAACTATTAATAAAAGTATAGTGCATCCTGAAAAAT +TATTTCTGCAAATGTATCTATAGAATTTAAAACAAAATATACAAAAAAAA +ATTATGAAAACCACGACGAAAAACCCGGAAATGTTTTTTGGGTAGCTTGT +CGATTCCGGAGGGTATTGAATTTCGCGCTCGAATAATATTGTTTCCTATT +CATTTTCCCCAGAATACCTACAGAATTTGGGGGAAAAATATGAACTGGTA +CCTAACATTAACCTACACGTTTTTTAAATAAGTTTAGGCCACGCCCAGAA +AGTAGCTGGGCGGGGTTGCAGATTTTTCTAGCTTTCCGAAATATAAAAAG +TCGGAAAAAAAGTTGTAGTCTGTAGTTTGTAGTTTGTAGTTTGTATCAGG +TTGTCCCATAAGTTTTTGTACTTTTTTTCAAATATTTTTCCAAAACTTCT +AGAAAGTTTTAAAATTTTTTCATCGTAGGTCGTGTCAAGGTCGGGTCGTC +CCCTTTCAGAAAAGATTCATTTCATCCATTTCTACTTTGCCACGATGACA +ATCATCAAACTTGAACGTCGAGACGTTAGATTGCTTCTTCTTTATGAATT +TCGTCTTGGTCATTCAGCAATGGAAGCGGAACGAAACATATGCGGTGCGA +TGGGTGAGGGAGCACTCTCTTATAATACAGCAAAGAGTTGGTTTCAAAAG +TTCAAGAACGGCGACTTCAGTCTCGAAGAAATAGAACGTTCTGGGCGACC +GGTAGAGTTAAATGAAGAAGACCTAGTGAAGCTGGTGGAGGAAGAGCCTC +GTCTTAGTCTTCGTGAAATGGAAGAGAAGCTTGAGTGTTGTCATAGCACA +ATTGCACGTCACTTGGGTCGCCTTGGTTTTACTTCAAAACTTGGAACTTG +GGTGCCTCATGAACTTTCGGCATCACAGAAGCTCACTCGGGTCAACGTTT +GTACTCAACTTCTAACTTTTCGTCGAAAGTTCGATTGGCTGAACAATCTG +GTTACTGGAGATGAGAAGTGGGTGCTCTATGTTAACCATTCCAGAAAACG +TCAATGGCTTCCGATCGGTGAGAAAGGAATACCGACGCCAAAGCCTGATC +TTCACCCAAAAAAGATTATGATCTGTGTCTGGTGGGGTGTTCAAGGACCC +GTGCACTGGGAATTGTTGCCAACTAATAAAACTATCACTGCTGATTACTA +TTGTGCCCAATTGGACCGAGTTGCAGAAAAGACCAACGGAAAATATGAAA +AACTATATTTTCTTCACGATAATGCTAGGCCTCATGTCGCCAAGAAGACT +TTCCAAAAGCTGCAAGATCTTGGTTGGACTGTTTTACCGCATCCACCATA +TTCTCCAGATCTTGCACCAACCGACTACCATTTGTTCTTGTCTCTCAGTG +ACTACATGCGCGACAAGCAATTCGACGACGAAGAGCATCTCAAAACTGAA +CTCTCCACTTTCTTCTCATCGCGTTCGCCGGATTTCTTCTCCCGTGGCAT +CATGATGTTACCTAGTAAATGGCAACAAGTGGTGGACACTAATGGTGAAT +ACTTGTGTGAATAGTACTACTTGTCGCTTGAGAGAAATAAATTTTTTTCA +AAAAAAAAATAGTACAAAAACTTATGGGACAACCTGATAGTTTTAGTTCG +TTATTTGCAAATTGTTAACGTTAGTATTAGGAGAGCCGAAATAAATAAAT +TTTAGAAAAGAAAACGAAATTATATACATAGTTCATTAAAATGTGGTAGT +TTGTAGTTTGTAGTCTATGTATTATGTCTATTCAAATTGTATTCAACATC +AAAAATTAAACAGGAAACTTATATTTAAAAAAAAAACGAATACTGAAAAA +AGGCGGCTGCATAGGAAAAAACAATGATTCTCCTCCAAAAAATAGAATTC +CGCATTTTTTCAGCGGCTATTTTCACGATGATGAGAGGAGACAACAAAAA +CATTTGAGATGAGAAATGAGGGGAATATTGCACAAAAATTGGGAAATGAT +TTTTTTTACTTTATACACAGTTAAAATGCGATGCGCGCATAGTGTTTTTG +GCGTGGATCGCGAGTGGGAGAAAAAGGAACCGGAAATGATGCGCATTGTG +CGTCCATCGCGAATTTGAGATGCATTGTGCGAGCATCGCGAACATAAATA +ATGGGCACATTGTGGATTCTCCTTTCTGATAATATTTTACTCTCTATGGC +TTCACCAATTATCTTTCTCTCTGTGGCTTCCCACTATATTTTACTCTCTG +TGGCTTCACCAATTATTTTACTCTCTGTGGCTTCCCACTATATTTTACTC +TCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCACCAATTATTTT +ACTCTCTGTGGCTTCCCACTATATTTTACTCTCTATGGCTTCCCACTATA +TTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCAC +TATATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTC +ACCAACTATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGG +CTTCCCACTATATTTTACTCTCTGTGGCTTCACCAACTATTTTACTCTCT +GTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTATATTTTACT +CTCTGTGGCTTCACCAACTATTTTACTCTCTGTGGCTTCCCACTATATTT +TACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTAT +ATTTTACTCTCTGTGGCTTCACCAACTATTTTACTCTCTGTGGCTTCCCA +CTATATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTT +CACCAACTATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTG +GCTTCACCAACTATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTC +TGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCACCAACTATTTTAC +TCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTATATT +TTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCACCAAC +TATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCC +ACTATATTTTACTCTCTGTGGCTTCACCAACTATTTTACTCTCTGTGGCT +TCCCACTATATTTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGT +GGCTTCCCACTATATTTTACTCTCTGTGGCTTCACCAACTATTTTACTCT +CTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACTATATTTTA +CTCTCTGTGGCTTCACCAACTATTTTACTCTCTGTGGCTTCCCACTATAT +TTTACTCTCTGTGGCTTCCCACTATATTTTACTCTCTGTGGCTTCCCACT +ATATTTTGCTCTCTGTGGCTTCCCTCTATATTTTACTCTCTGGCTTCACA +GTATATTTTATTCTCTGGCATCACAATATATTTTACTCTTTGGCTTCGCA +GAATATTTTACACTCTGGCTTCACAGAATATTTTACTCTCTGGCTTCGCA +GAATATTTTACTCTCTGGCTTCGCAGAATATTTTACTTTTTGGCTTCACA +GAATATTTTACTATCTATTAATCTATTTCTTCGTATAACAATCTATTTTT +TCGTATAACAATCTATTTTTTGTATAACCAACTTCAAACTCAACTTTTCC +AAAACTACAGTAACCCTACAGTAATTCTACAGTACTCCTAAAACTCCCCG +CAACCTGCAGTTCAATGACACCTCGTTTTCTCACGCGTGACTCATGACTC +ATTAGCTTACATTTCCTTCATCCATCGGTGGTGGGGCGCTGTGTAATATA +CAAGAAGAGACACCACCACACGCTGCTATTTCTGCTGCTGGTCTGTCTTC +GTTTACAGCCACTTATGACTCAGCACTGCCATCAATGACTACTTCCTTCT +TTTTTATCTTTTCGGCTTCATCTCGAGTAGCAAATTTAACAAAATTCAAT +AGGTGTGACGTCATCAAATGCCTTCGTGGCCTAGAAATCCAAGATTTCTC +TCGAAAGGATCAATGTGATGTCATGGCCTAGAAAACTCCAGTGTGAAACC +TAGGCTATGTTAAATAGTCTTGAAAACTCTAAACTGAAGCACATAAGGCT +ATGATGTCATCGCCTAGAAATCCCAATTCTATGACGTCATGAAAGACCTG +AACTGCACCGAACCTAGGAATACCCTCAAAAGGGGTGCTGTGAAGTCATG +TCCTAGAAAACATGAGTGCGAAAACTAGGCCGTAATCTACCATGTGGTAG +ATCATGCGGCCCTATTGATGGCCTAGAAAACTTACAGCTTGAAGCTATGA +CGTCACGACCTAGAAACTCAATAGTTGTGACGTCATCAATGACCTAGGTG +TATCTCGAATGACGCAGTGTCTTCTAGAATTTTCTGAATATCACACAAAA +GTATAACATCTTCTTGAAACCAAATAATTTTGTTGTAACACCCACACAGT +ATTGTAACAAATGATATAATAGCGATCGGAACATTCGAGAAAACTGGAAA +TTTGAGGTCTGACCTTGTTCGGGAAACTTACCAGTGATTATGAGGTGTGT +CGAAAAATGTGGCCTAGAAAATGGGAAAACTCTTCCTTTTTTTTTTTAAG +TCCAGAATTACGTTTTTGAGAACGAGAAGTGCATTTCATTTTTGTTAGGT +TGGAAATTTAAAATTTAAATATTCGTCTCCTAGTTACAGCCGTGGAAGAC +TTTTTCAGAAACTTTAGCCACGTGTCGAAGTCTGGCGGTGCCCACGATAT +TAGAGAATGTTGATATTTCCTATTTACTTATCTCCTCGAAATTTTAAGAT +TAAAGTTACTACCGTTAAGTTACACTGGTGGAAGAGTTTTTAAGATTTCT +AGGCCACGGCAAAGTTTGGGTGTGCCAGTGACCCTAACACTAAATTTTTA +AATTTTTTTCAGCCAAATCATCATATGGTGGCCTAGAAAATTTAACACCT +GAAAACTCTTCCATATTTTTTTAATTTCTGAAATCCAACAAAATAATTTT +CAAACTCCTCTTCCTTTTTTCCAGAAAAATAAATTAATGTAAATCAAGTT +CATCTCCGATGAGTTGTAACGGTGGAAGAGTTTTTCAGATTCCTAGGCCA +CGTCAAAGTTTGAGGGCTTCCCGTGACCCTAACACTAAATTTTCCAATTT +TTTCAGCCAACCCAAATCAGAAGCTTTCTCTTTGTGTAATAACATGACAA +TGGGCTATTATCATATGAAATTTTTTAGGTTAAATTTCTGAGGTCATTTG +CAAAGGTGTCATGACTAGTTTGGAGGCTTTTTTGTGACGGTAGGGGTATG +AAACAGGTTGTTACTTCTCGAAAAGGTATTATGTGGGGGAGAGGAGAAGG +AAAGAAGGAAGGCAGATTAGCCAACAGAGATACAGCAAATTTTGTGTGAG +TGGTGGCAGTTTTGAGAAGAAGCCATGCGCCAAGGTCGGTTTGCCTTCTG +TTTTCTCATTTTTCGGTTTTTTTGTGAATTTTTGTAAATTAAAAATATTT +TTTTATAGAAATAAAAATTCAGAAAAAAATACTGGAAGTTTCGTTTGCCT +TCAAACATTTTTTAAAAATTCACAGTTTTTCAAATAGATGTACTTACACG +TGGTGTCAGAGTATCTCATTTCGGCTTGATCTACAAAAAATGCGGGAATC +TTTTGCCCAAAAAAATGTGACGTCAGCACGCTCTTAACCATGCGAAATCA +GTTGAGAACTCTGCGTCTCTCCTCCCGCATTTTCTGTAGATCAGCGTAGA +TCAAGCCGAAACGAGACACTCTGGCACCATTTTATTTTTTTGGGCAAAAA +ATTCCCGCATTTTTTGTAGATCAAGCCGTAATGGGGCAGCCTAGCCCCAC +GTGCACTTATTCCTTATGCCGAACGACACTCCGATATCCCGTTTTTACAG +TATGACTGTGGGTTACTGTACCATTTTTGGTGCTTTTGTAATATTGTTTT +CTTTTTCAAAAACCTAGGAAAAATTTGAACAATTGTTTTTTTTTAATATT +TGAATTTTTTAGGCTCCCACACATTTTTGCGGGATATCGGAGTATCGATG +TAAACGTTTTTTTTTTGGTTTTTTGTATTAAAAAGGGTTTAAGTGTTGTA +ATAAGACATTTTGAATAAAAAATAGCTAGCGCCGCCACGACTTACTGGCT +TCCCTCCTAAATAAAAATGGAAGAGTTTTTGCCGAACTAGGCCATTTTGG +CTCGGCCGTATCTGGGGTAGATTTACGGCGCGTTGCGTGCCGCGTCGCGG +CTCGATTTTAGTTGTAAAACCTAATGTATTTGTTGTCCGTGTGGAGTACA +CGACTTTTCCACGCGTTGTCCGGCAGGCGATTGTCAATGGAGCGCGAAAA +ATTCAATGAGGAAGGCCAGGACACCGATTCAAAGATATAACGGCCCACAT +TTCAACAGCGGTATATCGGAGTGTCGTTATTTTAAGCTTGCACACGGGCT +TCTGGCCTTTTTCATTGCTTTTTCGCGCTCCATTGACAATCGCCTGCCGG +GCAACGCGTGGGAAAGTCGTGTACTACACACGGACAATTTTTTTTAAGTT +TTATAATGAAAACCGCGACGCGACACGCAACGCGCCGTAAGTCTACCCGG +GCCGAGCCGACACGTGGTGTCAGAGTGTCACATTTCGGCTTGATCTACGT +AGATCTACAAAGAATTTTGCATGATTAAGAACGTGCTGACGTCACACTTT +TTTGGGCAAAAAATTCCCGCATTTTTTGTAGATCAAACCGTAATGGGACA +GTCAAAATGGCCTAATTCGGCAAACTCTTACATTTCAAAATATGAGGGTA +GGCAAAAGCATGGGGAATTTGTGATTAAATTTTTGAAAAAGGAAACAATT +TTTTCCAAATTTCTTCTGAAATTTTTTCAAAAATAAATGTTTTTTTTCCC +TAAAATCTTCAAATTTCTAGTTTCAATCTCTCACTACCGTGACCAAAAAT +TCCTATGATTTTTGACCTCCCGCCACACAGTTTTACCACCAACTTCTTCC +CCCCCCACCCACCCACTTACTTCTCGTATCTGAAACTCCGCCCCATTTTT +CGTGTACTTTACTACTACTTGAATGATGATGAGGTAGAACAAATCTGTGT +TTATTGGCAGAAGCAGTGGTAGCAACAGGAGAAGAAGAAGAAGCATCACT +GTGTGGAACCAGCCAGCTGTGTTGTTGTGGTTTTAGTCGTGGAGAGAGAG +AGGACGACGTCGTGTGTCTTCAATAAAATGAGGATCTCATCGCTCTTATT +CCTGACTTTCTTGGCTGGAATTGTTCAGGTAAGCTGGGTTTTAAGTATTG +ATATTGGTGCTATTTGAAAATTATTTCAAAAATTTTTGGAAAATTTTTTT +TTTTTGGCCCAAAAATTTTTTTTCTAGAACTTTATCATTCCTAGGCATAC +TCTAAATATGTCTGCAAATATTATTTTTTCTGGAAAATTTTGAAAATGTA +TATATGGATATATGCAAGTTTGGAAGTTTTTGTAGTATTATTTTGAAAAA +TTATAAATTTTTTTAAAAAAAATTTTTTATAAATCTAGCAAGAAACGTTT +TTAAAAACAATTTTAGTCAATTTTCTTTTTTTTTTTTTGGAAATTTCACC +AAATATCGGCCCAAAATCTATGCAATACTATTTTTTCACAAAGAAATTTT +CAAAATTTGACATTATACAGATCTAGGGCTTCCATGGTAGGCAGGCGCGG +TTTCAGGGACCTGCCTGAAACCTACCTGGTTGCCGCCGGCCTTAATTTTT +ACGGGAATTTAGAAAAATTTCTAATTTTCTCATTTCTATCAATTTGATGA +AAACCAAAATAAATTGGCGAGAGGCAGGCAAAGGTTGCCTTAAGGTCAGG +CAGGTAGGCGTTTTAACACCTACCAGCTTTACAAAAGCACTATACAAGTC +TGTTTTTGAAATCTCTAGCTTTAAAAATCTTTAAAACAAGACATGGTGCA +AGACAAGACAAAGACATCGACAAATTTTCGACAAAATTAATTTTTTTCGA +AAAACTTTTAGTTTCTTCCAAATTCGCCAAAGTGAAAAAAAAGTTCCTAA +ACGTGAGATTTTGTATGTCTTCTACACATACTAGCCAATATCAATTACAA +TATCTGCCAAGAAAATCTCGAACCAAACACCAAAACGGCGTTTGGTAACC +GGTTTTTTTTCCAAAAAAACTATACATAGTTTCTAGTAAACAAATACGAA +TGGAAAATTCAAGGTGACAGAGAAGAAAAAAAGATTAGAAAAAAAATCGT +TGGTGGTGGCCTAAGAATTGCATGTAACGTCACACCTCGGCCAGGGGTCA +TGGTACATGCTACATGATTACCCATGGCAAAAGAGTGACGTCACTCTCGG +CCATGATTTTTAGGTTTAGGCTTAGGTTTAGGCTAAGGCTTCGGCTTAGG +CTTAGGCTTAGGCTTAGGCTTAGGCTTAGGCTCAAGCTTAAGCTTAGGCT +TAGGCTTACCTTATGAGCCTATAAGCTTTCTGAAAAAGACAAATATTAAA +AAAAAACCAAAAAAAAAAAAAAAAAAAGACAAACAAACAAATAAAAACAA +ACAAACAAATAAAAACAAACAAAATATTTGAATTTTTCTAAGAAGACAAA +TACGTCACTCTCGGTCACGATTTTTGGGCTTTAGGTTTAGGTATATGTTT +AGGCTTAGGCTTAGGCTTAGCCTTAAGCTTAAGCTTAGGCTTAGGCTTAG +GCTCAAGCTTAAGCTTAGGCTTAGGCTTACCTTATGAGCCTATAAGCTTT +CTGAAAAAGACAAATATTTAAAAAAAACCAAAACAAAAAAAAAAAAAAGA +CAAACAAACAAATAATTTTTCAGGCCCAAGACTTCCTTGCAATGTTCAAG +CCGTTCCTCGGAGGTGGCGGTGGTGGCGGTAATCCGTTTGCAAATCCACA +GGCGATCGGCGTAAGTTTTCCGACAGGCAAACAGACAAACAGACAGACAA +TCGAAAGTGGTCCAGGCGCTGAATGTGTTACGCAATTGGTTTTGGGCGCC +ACGCGCGCATATTATTTGCATATATACATACATCATTCAGATAAATGGCA +TTGAAAACGAACAAAAAGTGAAGATTTAGTGGGTTGGCAAATGCATTTTA +TGTTTCTTTTCCAGGGTCTCTTCCAACAATTCGCCGGTGGAAATGGTGGA +GGATTCGGGCAGCTTCTTGCTGGAGCAATGGCACCGGTATGTGTTGCGAC +GTTTAAAACGGAGTGTCGTTGTGAAATTTTCCGCTTTGGAAAACATTGAG +AATATTCGAAAATTTTTGTAAAATTTTGAGATTTTCTTTTTCCAAGCTTT +GGGCTTAGGCTTAGGCTTAGGCTTAGGCTTATGCTTAGGCCTATGCTTAG +GCATAGGCTTAGGCTTAGGCTAAAGCTCATGACTAGACTTATTCTTAGAT +TTAGGCTTAAGCTTAGGCATGGCCTTAGGCTTAGGCTTTTGCTTAGGCTT +TTGCTTAGGCTTTGGCTAAGGCTTAGGCATAAAAAAAGAGAAATTCCCAA +AGTAAAAAAAAAGACAACTTTTGACAAATTTGAAAGTGAAATGTTATATT +TTAAGCCTATTTTTTCCCTAAAAAGAAAAAAATTACTTTTATAGTTTGAA +AACGATTTTTTGGCAGTGTTTCAGCAGTCAAAAATATGGCTGAAAAAAAA +AGTTGATTTCAAAATATTTTTCATCTCAATTAATTCTTTTAAATTTGCTC +TACCAAATTTGAAAAAAATATTGAAAATTATTTTAAAAAATTTAAATTAT +TAAATTTCAAGTAAATTCGAAAATTTTGTTTATTTATTTTATGTTCATTC +TTACAATATAAATTATAATCCTCAAACATTCCAGAAACCAGCACCAGCCG +CAGCTGGACCCCGCTCAGCTCCAGCTCCAACCAACGAGGACTACAACACC +GACATCGACGTTCCAGCTCCAAAGGCAAAAGCCCGTGCAGCTCCAACTCC +ACGAAGAGCACAAGGTGATGATGATGATAATATTGATATGTCTCTGACAC +GTCTTGGCTAACTTGGCTTGGAAAAGCACAATTCCTTTAATACAAAAAAC +TTTTCTCAAAGATTCTCAAAATTTTGCACTTTAATTTTTAAGTTTAATTT +TTAAAAAGTTGTCTCACGTTTTTTAACCAATTTATATGCAAATATGATCC +TTATTACTAACAATATTTAGTAATCTAAACATAAATTGGAATATTTGGTC +TTTTTCCCGCCGAAAATGATCAAACATTCCGAAGTTAGCAACAGAAAATT +GCAGTGAATTGTGTTGGTTTAATTTTACCGTCGTTTTTCATATTTTTTGC +CCGATAGCTTTGCTGTGTTTTGTGCCATCCTTTTCTCTGTGATATACTGT +TACTTACTTCAATAAATGATTCTTTTAAAAGTTTTCGCACAAAAAATTTA +GAGTTGCTGGCAAAAATACACGCCGACACGTGGTGCCAGAATGTCTCATT +TCAGCTTGATCTACGTTGATCTACAAAAAATGCGGGAGAATGGAGACGCA +GAGTTTTCTATTGATTTTGCATGGTTAAAAACGTGCTGACGTCACATTTT +TTTAGGCAACAAATTCCCGCACTTTTTGTAGATCAAGCCGTGGTGGGACA +TCCTATCCCCACTTGCGCTGGGGGGACAAAACCGACATAACTTTTGAAAC +ATATTACACATATACATTTAATATATGTTTTCTGAGAGAAAACGTTTTAG +AAATTTTAGAGAATTTCAGCAAAAAAATTCTGATAGCTTTTTGGAAATTT +ATATTATAAAATTTTTTTTTTTTTTTAATTCTGATTTTTTCAAAAAAGAA +ATTTTGCAAACCGCTTCCAGAATATTTGCCTGTCTCAAAATACCCTAAAA +AACATTAAAATGTTTCAAAAATTATCTTTTGGAACAATTTTACGGGTCAC +GCGAAATACTTTCTTTGTAAGTTTTTTTTCTTTGAAATTTAGATTTATTC +CCAATATACGTAAATTTTTCACTGAAAGTTAGAAAATTATACTTGTTTTT +TTCCAGAAATTGAAATGTACATGATACAAGGCTGCTACATTCCAGCAAAA +TCTGATAAAATTTTAGAAACAATTTTTTGTCAGAGTCTTGAATATTTGAG +CTATAAGTTTTTTTTTTTCAAAAAATTAATCCAGTTTGGCCTAAAAACTT +AAGGCTAAGATTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTCAGCCTAA +GCTTAAGCCTAAGCCTAAGCCTCAGCCTAAGCCTAAGCCTAAGCCTAAGC +CTAAACTTAAGTCTAATCCTAAGTCTATTCACTAAAATTTTGACGTAAAA +CTTGGGACTAAAAATTTTGGACACAAATTTTTTACCTAATTTTTTGGTCT +AAGCCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAA +GTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGT +CTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCT +AAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAA +GTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGT +CTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCTAAGTCT +AAGTCTAAGCCTAATAAGCCTAAATAGGGTCTAACGCTTGCCACTGACGC +CGCTAACGCTCGCCACTGAAGCCACGCCTAAGCCTAAGCATAAATCAATT +TGAAACTTCAGACTTAAATTTCTTGGTGGCCTATACGACTCTCTGTTAAA +TTTCGCTTTGATCAGCAAACGGGAACCCTTTGAAAAATTAAAAAACTAAC +GCTCGCCACTGACGCCAAGTCTAAACCTAAGGGTAATACTAAGCCTAAGC +CTAAGCCTAAGCCTAAGCGTAAGCTTAAGCGTAAGCGTAAGCGTAAGCGT +AAGCCTAAGCCTAAGCCTAAGTGTAAGCGTAAGCGTAAGCCTAAGCTTAA +GCCTAAATCTTTCGACAAAAATTTTGACCTAAAACTTTGACCTAAAATTC +GAGACTAAATATTTTGGACTCAAATTTCGGCCTGAATTTTTGGACTAATT +CTGGGAACTATTCCAGAGTAATTTTAACAAATTGAAAACTTTTTATAGTA +TTCGTAAAACAAAAAATAAATGCAATGTTTTCAGTAATAAATTTGAAATT +TTTGAAAAATTAAATATTTCTTCGAAACTTCGAAACTTCCTTTTCTCTGG +CATAACCCCAAATTCCAGCCGATGCCCCGCCAGTATACCGCCAGCCTCGC +ACAAAAGCCGAAAAAATCGAAAGATTCCGGAATATCGCTCGGACATTCTC +GCCGTTCGTGTACGAGGTGAACACCACACCAGCTCCTCACTTTGACAACT +TCATCTGGCAACAAAATGCACCAGCTGTCACACCGGAGCCATTCACATTT +GCTCCATTCTCCTTCCCAACTCTTGCCACCGTCGCACCACCAGCTCCAGG +ACCCGGCGGCCCGACTCTTGAGCCATTTTTACCGACGACAGCTAGTCCGA +AGCTGTTAGCTCATAACACTGCTAGGGTATCAAAAAATTTGAATACTGAA +TACCTCCCTATAACTTTTTCAAATTCCAGATGATCCGAGAAATCGCTTCA +TTTTCCGACGGAGGACGCTCCAGGGATCAGGATTTTGGCGCAGTTCAAAC +GCTCATGCAAGCCTTCTTCGAGGCAGTCTCCAGTGGAAATAATGGTGGAG +CAGGAGCTGCCGCCGGAGCCGGAACAGCTTTAGGAGTAGGTTAAGCTCAC +TAAAGAGGTCGTGAAGTTTTACTATTTTTTAGGATGCTCCAATGCTTCAA +GCCCATCGAGATGGTACCGAGTTGGGAGCCAATCGCGCGCTGACCAACAA +GCTTTTCGAGTCGGATATGGTGTTGACGGTCAAGCAGATGAAGGCGTGAG +TGTGGGGTACTGTGCAATAAGATTATTGTAGGGGTACTGTAAGATCTCTG +TAGGGATACTGTAACCCTACCGTGATATTACTAAAGGGGTGCTGTAAGAT +TACTGTAGGGGTACTATAGGATTACTGTAGGGGTACTGTAAGATTACTAA +AAATATACTGTGAGATTACTGTAGGGGATGCTGTAAAATTTCTCTAGGGA +TATTGTAGAATTACTCTAGGGATACTGTAGAATTACTGTAGGGAACTGTA +AGAGTACTGTAGGATTACTAAAGAAGTACTGAAGGATTACTGTAGGGGTA +CTGTAAAATTACTATAGAGTACTGTAAGATTTCTGTAGGGGTACTGTAGG +ATTACTGTAGTATTACTAAACAAGTACTGAAAGATTATTGTAGGGGTACT +GTAAAACTACTATAGAGTACTTTAAGAGTACTGTAGGATTACTAAAGAAG +TACTGAAAGATTACTGTAGGGGTACTGTAGGATTACTGTAGTATTACTAA +ACAAGTACTGAAAGATTACTGTAGGGGTACTGTAAAATTACTATAGAGTA +CTGTAAGATTGCTGTAGGGATACTAGAAGATTATCGTAGAGATACTGTAA +GATTATTGTAGGGGTTCTGTAAGATTTCTGTAGGGTTACTGTAGAATTAC +TGTAGGGTACTGTAAAATTACTGTAGGGGCACTCTAAGATTACTGTAGGG +ATACTGTAGAATTACTGTAGGGTTACTATAAGTTTACTATAATATTTCTG +TAGGGTACTGTAAGATCACTGTAGAGGCTACTTTAAGATTCCTGTGGGGG +CACTGTAACACTACTGTAAGATAACTAAAACGGTACTGCAGGGTACTATA +AAGCGACCACCCTAGATTCATGGTTATTTCAGAATTGTGCTCGCCGCCCA +AGAGGCCCGTAACCCTCACGGACGTAAAAAGCGAAAGGTGATTACGGGAT +CCGTGTACCGATGGAAGAGTGTGATTCCGTTCCGATTCAAAGGTGGCGAC +GCGAAATGGAAGAAGCTGATCCGTGAAGGCCTAGGCCTATGGGAGAAGGA +GACGTGTGTGCGATGGAGCGAGAATGGCCCCGGCAAGGATTATGTGATCT +TCTTCAGAGGATCTGGGTGAGTTGACATGCCCATGGTTTTCGGATAGTTT +GGGTTTTTTTTCAGATGCTACTCATCAGTCGGAAGAACCGGAGGATCTCA +ACTTATTTCGATTGGGTATGGCTGTGAAGATGTAAGTTTTAGTATTTCTA +CTATACTATTTATTTTAAATTCAAATTTTCTAGAAAGGAATCGTTGCTCA +CGAAGTCGGTCACTCCCTAGGCTTTTGGCACGAGCAGTCCCGTCCGGATC +GGGATGACTACATCCATTTAAGAAAAGACTGGATTATTAAGGGAACCGAT +GGAAACTTCGAGAAACGAAGTTGGGAAGAAATCGAGGATATGGGCGTTCC +GTATGATGTCGGAAGTGTCATGCATTATGGGTCGAATGTAATTTTAAATT +TTGAGTCGGTAGTTTTTAGATACTGAAAATGATTTTCAGGCTTTTACAAA +GGACTGGGACCAAATTACTATTGAGACCAAAGATAGTAGATATCAGGGAA +CGATTGGTCAACGCCAGAAGCTTTCGTTTATCGATGTTAAGCAGGTTAAC +AGGCTTTATTGCAATTGTGAGTTGTTATGCAAAAATGAAAAAAATTTGAC +CACTGAGCGGATCGAACGCCCAACCTTTCGATCTGGAGTCGAACGCGCTA +CCATTGCGCCAAGCAGTCACATTTTGTTGCAGGAAACGGTGTATAGAGGA +GAAAAGAAAAAAATAGACAACCCTACGTTTTATCAGTGGAGCGCGGTTGC +AATTTAACATTCCAATTTTCAGCTGTTTGCCCGGTTGCCTTACCCTGCAT +GCATGGAGGATACCCCGACCCCAATAACTGTGCGGTTTGTAAATGTCCAG +ACGGGCTCGGAGGAAAGTTGTGTGGACGTGCCGCAAAGGGCACAGATCAT +GGTAAAACTCCACTGGAATTTATGGGAAAAAACCGCCCTAAAATTTTCAG +ACAAATGCGGCGGTGAGCTAACAGCGACCGCCGAATGGCAGGAGATGGTC +TACAAGGGGAAGCGGACGTGCAATTGGAAGGTGAAGTCGCCGAGCGGTGG +GCGGGTTCGGTTGGTGCTCACCGAGCTCAGGTACCAGTGTGCACCGGCGT +GTAAGGCCTACATCGAGATCAAGCATAATACCGACTTCCAGCAGACCGGA +TTCAGAGTTTGGTGAGAACCCTAGATTCCCAAAAAATTCTACACTTTTTT +CAAAAAAAAATCGAAATTCGACCCATTTTGGCGGGAATTAAAATTCTTTT +AAAAATGACAAAAAAAATATTTTTCTGCAGAAAATTTTTCGACTTTTTAG +AAAGCAAGCTTTCACGCGGTTTTGGCTTCCCTCATATATTGAAATGGAAG +AGTTTTTGCCGAACTAGGCCATTTTGGCTCGGCCATATCTGGGGTAGATT +TACGGCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAAATTTAATTGTCC +GTGTGGAGTACACGACTTTCCCACGCGTTGTCCGGCAGGCGATTGTCAAT +GGAGCGCGAAAAATTCAATGAGAATCGAGCCGCGAAGCGACACGCTACGC +GCCGTAAATCTACCCCAGATATCGCCGAGCCAAAATGGCCTAGTTCGGCA +AGCTCTTCCATTTCAATTTATGAGGGAAGCCAGAAATCCGTGTAAATTTT +TAATTTTTTGTTGCTTAAAAAAAAAAACTAAACAACTATTTTCCAATTCA +AATTTCTAGCTGCTTCAACAAAACATATGACGTCATCTCCGACCAATCTG +AAGCCCTGATCCTCTCCAACGCGAACATCGTGGACTACGAGGTCTCCTAC +AAGCTGCAATGGATTCAAGGTACCCCACCCCCCCCCCCTTTTCTATCCAT +AGAGCGCACTTTCTTCCAGACAACGGAAAAGCTCTTCCACCACCGAAACC +CACGTCGACCTGGGTGCCCGGAAAAGAGAATCGACCATTCCGCGGAGTGG +AGAACTCGGGCGGCACCATCGAAAAGTTCATCCTGCAAGCGATCCCAAAG +ATCCGAGACTCGCATCGGCCACTGGAGAGTATTACTAGTATTGTTGCGGA +ATATGGTCTCGCAACGCTACTTGGTATATCGCATAATGGAAAGTAGTCCG +TTTGGAACGATTTTTGCAATCGTCAGAGGAATATATATATATATTTGTAA +ATTTTGTACCATCCCAAAAATCCAATTTTTCTTTCACAATTTTCAAAATT +TGCTCATCTTTCACAATTACTCGGGTTAACACATTTAATGCCTTTCAATA +AATAACAGTTCATATTTAAAGTGATTATTATATTACAGGAACACATATAT +CTGAGAATGCGTATCGCACAACATATTTGACGCGCAAATATCTCGTAGCG +AAAACTACTTTAAAAGACTACTGTAGCGCTTGTGTCGATTTACGGGCTCC +TTTTTTGAAATTTACACGGTTTTCTGGCTTCCCCTCAAAAATTGATATGG +AAGAGTTTGCCGCGAACTAGGCTATTTTGGCTCGGCCATATCGTTCAAAA +ACTACAGTAATTCTTTAAATGACTACTGTAGCGCTTGTGTCGATTTACGG +GCTCCATTTTTGAGATTAATTTTCTTTCGAGTTCCCTTCGTTTTTTTTGT +AATTTTTTGCTTAATTTGAATTTTTTTTTGATAAATTAAAAAAAATGATT +TTACACGGTCTCCTGGAGTGTTCATAATTATTGGAGCGCACTTGCTGATC +CTTGCCGCGCTTATTTACTTTTTCACCGTTAGAAAATGAGTAAAATCAAC +GATTTTGGTCAAGAAATTTAAAATAAAATTATTAATTGATTTCAAAACCG +AGTCCACGTGGTGCCAGACTGCCCCATCACGGTTTGATCTACAAAAAATG +CGGGAATTTTTAGCCCAAAAATGTGTGACGTCAGCACGTTCTTAACCATA +CGTTGAGAGTTGAGAATTCTGCGTCTCTTCTCCCGCATTTTTTGTAGATC +TACGTAGATCAAGCCGAAATGAGACACTTTGACACCACGTGCGAGTCCGT +AAATTGACACCAGTGCTACAGTAGTCATTTAAAAAATTACTGCATGTCAA +AATTAAAATTTCCTGTTCCCGTAATATCGGATTCAGCACGCCACCCTATG +AAAATACCAAAATTGGAAAAAAATCAATAAAAATTTATTTTCACGGAAAA +AAAATTGAGACCACCTTTTTGTTTTCTATCTATATAAACCCGTTGTTTTT +CACAAAAAATTATTGAAAATCCTTCAAATCATATTATTAGTTCGAAACGT +CGACGCGTAGGTGTTCGATCGTACACTGCCGGGAATTGCCGGTTGCGGGA +GTTTCGGCACCGCCGGTTGATATCCTTCTTTGCTAACTTTTGATCTGAAA +ACATTGACTTTTGCTACGTGGCCGTGGAAGAGAAAACTCGGCCACTATGT +TTGTTTTTGCGACAAGGGTATATGCGCAAACCTACAAAATGATCTTCAAA +AAATGCGCGAATTTTTTGCCCAACAAAATGTGACGTCAGCACGTTCTGAA +CCGTGCGAAATCAGTCCCGCATTTTTGTAGATCTGCGTAGATCAAGCCGG +ACCACAAAAATATCAAAGTTTTGAATTTTTCAAAAAAAAAGCACTTACGA +GGATCTAGTCAGCTTGAACAGCAAGTAAATAAGACAAAACGCGCACATGA +TGAAGCTCAAAAGTAGATCAAACGAGAACTTGGTCGCCGAGACCGCATTG +AAACTTCTGTCAAGTGAGAGAAACGGTTGGGTGGCATCGTTCACAAATGA +AAGCATGTAGAATAGTCCAGCAATCGGATAGACTGCCGCAATGACTCCGG +CAAACCCATTGACATCCTGCTCATCAGAGCCCAGAAGCCGGCAGCAAGCA +GACGAAAGAGCAATGGAGCTGATGAGGAATAGAATGAGCTCCCGGCAGAA +GTTGAAGATCCAGTCGGTGCCCGGGCTTGCTGCTCCGATGAAGCAGAGTC +CGGTGAGGGGATTGGCGGCGACGGCTTTTGCGAGTAGCGCGAGCATTAGT +GGAGCCAGCGGGATTCCCAGGATGAGCATGATCACGCGGGTTCTGGAGTC +GTCCTGGAAGATCATTTTTTAAAATTTAATTTTTGAAAATTTATCATGTC +TGGAAAAGGTACAGGCTGACTAGACCTATTTCACGTGGTGTCAGAGTGTC +TCATTTCGTCTTGATCTACCATGATCTACAAAAAATGCGGGAGAAGAGAC +GCAGACTTCTCAACTCTCAACGTATGGTTAAGAACGTGCTGACGTCACAT +TTTTAATGTACAAAAAATTCCCGCATTTTTTGTAGATCAAACTGTAATGG +GACAGCACAAAATTCAAAGCCCTCACCAATATATGCGATGTCCTTGTCGC +CTTATTCCACGACACACAGATCAAGAGCCACCAGAGACGTGAGCAAGTTG +CCGTGTAGTAAATCAGTGAGGCCACTGAAGAACATGGAACATGGGAAAGC +CCTCCGACGACGAAGAGCAGGTGATGGGTGTAGTCGGTGCACGAGATTTG +GAACTTCAAAATTCTTTTTGAATGGCTCAAAAATATTGATTTTGAGCCAA +GTTATGACCATTTGAAGTTGGTGGCCTAGGATTTTCCTAGGAGTATTCTA +GGCCGCCAACTTTGGACAGCCATAACTTGGCTGAAAATCAAAATTTTTGA +AATCTAATTTCACAGTTGAATTTAGCAGACCATGAGCTTCAATTTGACAT +ATTTTTGTGCCTTGCCACGAAAACTCGCAGACCTACAGTAATCCGGCCAA +AATTAATGTTAACTGAAAGCTCAGAGTCTGCTAAATTTAAATACAAAGTT +CGATTTCCAAAATATCGATTTTCAGAAAAATTATGAAGACTCTAAGTTGA +TGGCCTAGCATTTTCCTAAGAGTATTCTAGGCCGCCAACTTCAAACGCTC +ATAACTTGGCTCAGAATTAATATTTTCGAGCAAAATAAAAAGAATTTAAC +ATAAAATCTTGTGATCTACCGGAAACTAGATGAGCGCAATTTTAAATATC +TAGGCCACCAAGTGAAAACCGTGACTCGGCTCAAAACCATTATTTCTGCT +TCAACCAAAAACCAATTCATTTATTTTAATTGAAAGCCCGGTGTCGGCTC +AATTCAAATACCAAGTTTATTTTCAAAATACCAATTTTCAAAAAAGCTAT +GAGCGTTCTAAGTTGGTGGCCTAGGATTTTCATAGATTTTCTAAGCCACC +AACTTCAAACGCTCATAACGTGGCTTAAAATCAATATTTTCGAGCAAAAT +AAAAAGGATTTAATATAAAATCTTGTGATCTATCGGAGAATGCATTTTAA +ACTTTCTAGGTCACTAAGTAAAATATTCGGCCACCAAGCCTCGGCCGAAA +ATTATTATTTCTGCTGAACCAACAACCAAATTCTCCAAAAACTGCTTACC +TGATCTTTAAACGAAATGCTCACAATATAAATAACCGATGTCGCACAAAA +CGAGATGCACGAGAAGAACATGGCAGTTTCCGTAAGTGAGTGGAGCATCT +CGAGACGTCTAAAGTAGATCCTGATTTGTTTTTGGAAAATTAGGCCACAC +ATCACACAATCCAAAACTTACGATAAGCCGACTATGAAGACTGATAGAAT +TGTTAGTATTACAGAGCTCAGCGAGAGAAACAACAAGAGTCGGGTGGCGG +ATTCACGGTCAGTCTGGAAATGTACTCATTTGTTACTGAACTAGGTCTAC +TTAAGCCTAAGCCTAAAGTAAGCCTACCTGCCCAACCTTCTGTGGGTTCG +AGCACAAAGGCACACACTTTGAGGATCGATTCAGGAACACCTCATCCTGT +GGGCATTTTCCGTTGAGGCGGTCGACCTCCCGTTGAATATCTTCTACTCG +ATCATTACCGTCGTCCTCCTGGAAAAGAAAGATGATTGATTTGAAGCTGT +GTATCTAATTACCCCCGTTTGATGATATAGGACCGGAGAGATTACAATCA +GATGTTCTCTGTTTTTCTCTGTTTTTTGGTAGCTAGTATAGAAAACTATA +GAGTACTGTAATTCCTATTTGGGAGCTTGGTATTGTGCTATTATCAAAAA +AATACAATTGCACAAATTTCTCATTGATCTACCTGTTGAACTTGACTCCG +CCCCCAATCTTGTTACTGTTATTATTAAGGTAGATCAAAAACACAAGGAA +GATCAAAAATAAATTACGAGAAAATTGTGCGATTGTATTTTTTTCTATAA +TATCAAACATTTATTGATTTTAGGACATTCTGTGATTAACTTTTATAGTT +TCACGGATTTCTGGCTTCCCTCAAAAAATTGAAATGGAAGAGTTTTCGCT +GAACTAGGCCATGTTGGCTCGGCCATGCGTGGCGCGTCGCGGCTCGATTT +TAGTTGTAAAACTAAATATTTCCCACGCGTTGTCCGACAGGCGACTGTCA +ATGGAGCGCAAAAAATTCATTGAGGGAGGTTTCTATTTGGCAATGCGCTT +TTGGTTTTTCAGTGATCTTTCAAAAAATTTTTCATAATTTTCAAATGATC +ATAACTCTGAAACTAAAATTTTTGGCAAAAAAAGTCGTAATATTGTAAAA +TGTTGCTCATAATTTCTTCTATACGATAAAATTTTTTCAAAATTTTACAT +TAAACAGGCCAATAGGTACAGCGCCCGACAACTCGCGGGTCCAAAAATTT +TTCAAAAATCGTCAAAATTCGACTCGCGAGATGTCGAGCGCTAAATCTAT +TGACTTTATTTTTTTGAATTTTTGAAAAATTTGTTATCCAATAGAAAAAT +TTATGAGCAACATCTTATTAGTTAAGCGTTTCTTGCCAAACATTTTATAT +TCAGAGCTATACTCATTTGAAATTTTTGAAAAATCACTGGAAAACCAAAA +ACGCGGCAAACGATTTTTTCCGGCAAATCGGCAAATTGGCAAACTGCCGG +AATTAAAAATTTCCGGCAAATCGGCAAACCGGCAAATTGTCGAATTTGCC +GAAAATTTCGGCAAATTGTGGTTTTGCACTTTTTTTGGAAATTTCAGAAT +TCCAATTTCAAATTGCAAAATTAAACTCATCCTATGAATGTTTCTACATC +TATTTTGAAAAGTAAGTAAATTCTATGAAAATATATAAGGAAAACGAGAA +AAAATTCAAAAAGACATAGTTTTAAGTGTTTCCGTCTTATTAAAAAATCC +CTCTAAACTTTTCCGGCAAATTGATATTCGGCAAACGGGAAATTGGCGAT +TTGCCGGAATTGAAAAACCCGATACTTACACTTTCTTTCGCTGCAAACTT +TGCCCTCTCATCTTGAATTGCTCCTTGCTCATTTGGCCCTTTCATGCACA +TTTTCTCTCGATTGTTCTCCAACGGGAACTTATCACAACGAATCACATCG +GGCCACTTGAAACCGAAACTTTCCAGCACTGGAAGACACTTTTCCTGGAC +GGAAAGACACAATGGACGGCATGGACCAATTGGGTTGGCTAGCTGAAATT +TTTTTGAACGATGAAATGATAAAAATGTGCGATTCTTCTCTGATTGAACT +CACTTTCTCGTTGCACATCGGGAAGTAGACGGAGCACAGGAAGAATTTGA +GCTGCTCGGAGCAGACAACGGAGAGCAGGGGCTTGTAGGTGAGGATGGAT +TCGGAGGCGTCTTTCCATGATTCCTCGTCGACGAGATTTGGGAAGCTGGA +ATAAGGGCTTGTAAAGTTTGAGAAACTTGAGATTTACAGGGTCAAAAATT +GCTCACGAGCTCTCCCGGTTGCCGAAAAGTTGCCGAAATTTGAGCAACCA +AAAGTTGCCGATTGCCAAAAATTGTAGGGTACGGCAACTTCGGCAATCGC +CGGTTACCGAAGATTTTAGAGTTCGGCAACTTCGGCAATTGGCGGTTGCC +ATTGCTCTCACGAAATTTCCCGCTATTTTTGGAGATTAAACAGCAAGTGC +ACGTGTGGGTGTCTCAAACAGGAAAGAAATCCTGGCAGGAGCCGACTTGC +CGGAAATTTTCAATTCCGGCAAATTGTCGGTGTGCCGATTTGCCGTTTGC +CGGTTCTCAGATTTGCCGGAAGTGTGTAGAGGGATTTTTATAAGACGGGA +ACACTGAAAACTGTGCCTTTTTGAATTTTTTCCCGTTTTCTTTGGATATT +TTCATAGAATTTGCTTACTTGTCAAAATAAATGTAGGAACATTCATAGGA +TGCGTTTAATTTTGCTATTTGAAATTGAAATTCTGAAATTTCCAAAAAAA +TGAGTACAAAACCACAATTTGCCGGAATTTTTCAATTCCAGCAATTTGCC +GATTTGTCGTTCTGCTGGTTTGCCGGAAATTTTCAATTCCGGCATCTTGC +CGATTTGCCGATTTGCCGGATTGCCGAAAATTTTCAATTCGTTAGCCGTC +CACCCTGGATCCTGCCATCCAAAAAAAAACGGAAATTTTTGGCAAATTGC +CGTTTTTCCGCCGGCAAATTCGGCAAATCGACAATGTGCTGTTTTGCCGT +TTTGCCGGTTTGCCGGAAATTTTCAATTCCGGCAATTTGCCGATTTGCCG +ATTTGCCGGTTTGCCGGAAATTTTCAATTCCGGCAATTTGCCGATTTGCC +GATTTGTCGGATTGCCGAAAATTTTCAATTCCGGCAATTTGCCGATTTGC +CGATTTGCCGGTTTGCCGGAAATTTTCAATTTCGGCAATTTGCCAATTTG +CCGTTTTGCCAAAAATTTTAGGGTTCGGCAAATTCGGCATTTGCCGTTTT +GCCAAAAATTTTAGGGTTCGGCAACTTCGGCAGTTGCCGGTTTCCGCACA +TCCCTGTCCCACACGCCCCAGGTGGAAGATGGTGGAAGAGTTTCTAGCGG +GTCCATCAAGGATGGGAATCATCAGTCAACACAATCCTTAGCCGACCTTC +CCAAATTCATCATTCCTTCCTTCCAAAACGGTTTCCGGTCCTTCCAACCG +ATTAATACCAGCCACCACCACACCACCAAACCCTCTCCTTCGAAATAGAG +AACAAAGTTGCATACCCCCCTCATTTCTTTGTTTTGGAGAAAGGGGCGTT +TTGTGGTGCTCGGAGAGCCTGAGGACGTGACAAGTGATATATAGACGGGC +TTATACTATCTGCTCGTCCATATTTCACGCGCCTAGGCAGAGTGCACGGC +GGGAGGTGGAGACGCAGGTTCCCGTCCAACTGCCGCAGAGCATCCCCTAT +CTGCTCCTATCAATTGTTCGGAGAGACTTTTTTGTGAATTTTGCTTTTTG +CAAGAGGTCTGAGATTTGGGATTTGGGCTTTAGGCTTTAGGCTTTGGGCC +TTGCTTTGCGCCAGAGAATGGAAATTTGTCCGTATTTTCCCGGCTTATAT +CAAAAAATGATCAACTATAAAAATATAGAAAAAGATTTTTCAAGTTTTTT +GTCAGTTAGTATTTTTTGATAAAACAAAAGAGAGCCGAGATATAAGCTGT +CAAAGTAGAGCAAGGGTGGTTTGATCTACAAAAAATGTGGGGATTTTTTT +TCAAACTTGCTCTACTGATAAATTAATAAATTACTCCCACAAAATCCAAT +AAGCCTCAAACTTAAGATCCTCCAATCTCATCCCCCTCATAAAACAATAA +TACTAAATCACTAGATCTCCGGTAGTATATATCAGAAGAACAGTTGCTCT +CCCTCTCGAACCGACTTACACTTGAGAAAAATAAATTGTGGAAGAGAAGT +GACGTCATCGTAACCTACCACTTCACAAGTTTATATATATATATATATAT +AAGTACTAGTTAGGACTAGCTAAGACCTAATTAGAACATAGGTATGGCCT +GTAAGTTAGGACCTAATTAGAACTCACTAGGACTATATATATATATATAT +ATATATATATATATGTAAACAAGAACCCGGGCGGGTAACCCCTTACGGTC +AGAGGGGTGTCCTACACCAAGGGTATGTAAACTGTGTCCCCCAGATGGCG +AAGTTGAGAGGGAAAAAGTGAAAAAGCGCGCCACATGGCCTCGCGACCGT +ATGTTGCAATTTCAAGCAACGTTTTTGATTTATTGGAGGAGAAATTTTGA +AAAAGTGAAAAAAAAGTGTGACCCCATATGAGATGCGTAATAAAATTCCC +TACAAGACCTTAAGAAAACGTGGCTGGCTGGCAAAAAACAGGTGGCAATA +ATAACGGAATGTGTATGTGTGTGTGTGTGTGTGTGTGTGCTCGAAGAGCA +TAGGCTCGTAAATCGTTATAATTGATGCTGGAGGAGAAGGAGACGATGGG +CCTCCAAAGTGTTACACCTGGTATTTGTTGGGAAAAATTTGGGGGAAATA +GGCATTAAACTACCTAACCTAATTGAGTTTTTTCAAAGCTTATATTATTA +TAACTAAGAGGTGTGATAATAAATAATTAAAGAACTTTAAAATTATCAAA +AACGCTTTCAAATCTGTAAAGCTGATATTTTAAGGATTTAGTACTAGTTA +AAATCTAGTTGGGACCTAGGTAAGACTATCTAGAAAGTTCGGACGTAACT +ATTTAGGAACAGTTAAGTCTTAAGGCCTGCTTGGGTACAGGTAAAAATGT +TTAGAAAGTTAGGAACTAAATAGGTGAAGTAAGTACTAGTTAGGACTAGT +TAAGACCTAATTAGAACCTAGGTAAGGCCTGTAAGTCAGGACCTAAATAG +GACTTACTAGGACTTAGGTAAGACTAGTTAATGTCTTGTTAGGACTAGTT +AGGACTAGCTAAGACCTAATTAGAACCTAGGTACGGCCTGTTAGGGAAGA +TCTGATTAGGACTTACTAGGATTTAGGTAGGACTAGTTAAGATATAGTTA +GGACTAGTTAGGACTAGTTAAAATTTAATTAGAATCTAGGTATAGCCTGT +AAGTTAGGACCTAATTAAGACATACTAGGGCTTAAGTAGGACTAGTTAAT +ACTAGTTAAGAACTAATTAGAACATAGGCACGGTCTGTTAGTTAAGGCCT +AATTAGGACTCACTAGGACTTAGGCAGGGCTAGTTTAGTTATTGTTAGGA +CTAGTTAGGACTAGTTATGTACCTAATTTGGACTCACTAGGACTTAGGAG +GACTAGTTATAATCTTGTTAGTAATATTTAGGACTAGTTAAAATCTAATT +AGAACCTAGATATATCCTGTAAGTTAGGACCTAATTAAGACTTGATTTGC +TAGGATTTAGACAGGACTAGTTAAGATATTGTTTGGACTAGTTGACTAGT +TAAGACCTAATTAGATCTTAGGTACGGCCTGTAAGTTAGGGCCTAATTAG +GACTGAATAGGACTAAATTTCTTGTTACGAATAGTTAGGACTAGTTAGGA +CTAGTTAAAACTTAATTAGCACCTAGGTACGGTCTGTTAGGGAATACCTA +CTTACCAGGCCTTAGGTAGGACTAGTCATGACCTAATTAGAACCTAATTA +GAACCTGGGCACGGCCTGTTAGGGAAGACCTAATAAGGACTTACTAGGAC +TTTGGTAGGACTAGTTAGGACAAGTTAAGACCTAATTAGAACCTTGGTAT +GGCCTGTAACTTAGGACCTATTTAGGACTTACTAGGACTTAGGTAGGACT +AGTTAGGACTAGTTGGAAGTTGGGACCTAACTAGTTAGACCCTTAATTTT +GTACACATGCTTATTAATATCAATAAAAATTTTAAAAAAAAACGACTTTT +TTAAGTTTAACTATATAAAACTATAATTTGGAAAATTTGCTACTTTGCTT +AAAAATCGAGAAAAAACCTAGCGTTTCTATAAAAAACCATCTTGAAGTAA +ATTTTGAAAAAACCCCGTCATCCAACAAAAAAAAATTCACTCACCTCGTT +AAGTTATACGGCAAATCGTTGCACATCTCATGATCCACCTTTTGACACCT +CTGCCCGTCCACACCAATCACAAAGAGCAACAGGAGCCAGGTTACTCCGA +GGTAACCACGAAATGGTCCCATTAATGATAATGGAATTGGGGGCTCACAG +CCTGGGTGGGGGAAAATATTGAGAGTAAAAGAAACAATGAGAAGAAAGAC +GGAGGATAGGCGGGGGGGGGGGGGGGGGCACACCAGTGGCAGCACCACCA +CGGCCTGTCCGTTGACAAATGACCCAAACGGACGGGGGGCGGGAAGAGTG +TCTGTTGTGTGTGTTGGGAGATGGCTGGCGGTTATCAGATATTTGTATGA +ATGGTATAGAGAAACAGAGACCAAGAGAGCTGAAAGATGGAGAGGCGAAA +GAGGAAGAGAGGGGGGGGGGTGGAAGTTTTTACGAGCCCTGTAATAAATA +TATCGAAGCAGCAAATCATTTGATGATAACGGAGGAGCGCGGGGACGGAG +ACGGCAATCATCATCATTATTAGGACCAGGGGTGTGCGGCGAATTTTTGC +CGAATTTGCTGTTTGCCGAGCTCGGCAATTTACCGAATTTGCCAAGCTCG +GCATATTTCAAAAAAGTAGATTTGCCAAATTTGCCGAACTTGGCATATTT +CAAAAAAGTAGATTTGCCGAATTTGCCGAGCTCGGCATATTTCAAAAAAG +TAGATTTGCTGAATTTGCCGAATTTGCCGAGTTTGCCGAGTTCGGCAAAT +TTGCCTATTTAGCCGAGCACGGCATATTTCAAAACAGTAGATTTGCCGAA +TTTGCCGAATTTCCCGAGCTTGGCATATTTCAAAAAAGTAGATTTGCTGA +ACTTGCCGAGCTCGGCAAATTTGCCTATTTAGCCGAGCACGGCATAGTTC +ACAAAAGTAGATTTGCCGAATTTCCCGAGCTTGGCATATTTCAAAAAAGT +AGATTTGCTGAACTTGCCGAGCTCGGCATTTTTCAAAAAAGTAGATTTGC +TGAATTTGCCGAGCTCGGAATATTTCAAAAAAGTAGATTTGCTGAACTTG +CCGAGCTCGGCATTTTTCAAAAAAGTAGATTTGCTGAATTTGCCGAGCTC +GGAATATTTCAAAAAAAGTAGATTTGCCGAATTTGCCAATTTTGCCGTTT +GCCGAATTTGCCGAGTTTGCCGAGCACGGCATATTTCAAAAAAGGAGATT +TGCCGAATTTGCCGAATTTGCCGAATGTGCCGATGCCGAGCTCCTGTTGA +TTTTTTTCCAAAAATTCAGTAAAACGACACAAATTTGTTTTAAGAATTCA +TTAGTTTCGGTGCTCCAAACAACATCAAAAAATATCAAATTTTTCCGAAT +TTGTTAAGCACGGCAAATTTGCCAAATTTGCCGAATTAGCCGAGCACGGC +TAATTTTGAGATTTGTCGCACACCCCTGATTAGGACCGAGAAAAGGGCCT +AACATGATTTCACAATTTGAAAAATGAAATTCAATTTTTCTTGGGAAAAA +AGTATGAATCTCTTCCTCCGCCCGTTTCCGGCAGAAACAATTGAACCAAA +CGAGCCAAAAGTGCACATTGTGTAACTTTGTTGGGGAGTGTAGATAACCA +GAAGAAACAAGATGGAACTTTCTTGCGATGAACAAATTTTGGAACACTGG +AGGGAAATGATTGGTGTTTTTTAAGCTTTTTAGTCAATTTTTAAAACTGT +TCTACAATAGGCCCAAATAGGCCTAATAGGCAAATAGGCCAAGTAGATTA +AATATGCCAAATAGGCAGTATAGGTTGAATAGGTAAACAGGCCAAATAGG +TCAAATAAGCTAAATAGGCGAGACTGGTGCTCAAATACTTTTTGAACTGG +TAATGTTTTTTCTTCTACACAAAAACAAAAAAGTCCCTGCTTAGTTCCGC +AAAATTGTGATTTTTTTCAAAAGTTACCCATTTTTGCCACTTTTCAATAG +TTTTTGATAGGTTAAATCTAGATTTTCTGAATTCAGCATATATGAATTAC +CCGTTTTCAACAAATTTAGGCAAATTTTTATTTTTGCCCAATTTTTTTAG +CCATCTAATGACTGATTTTGGGCAAAAAAAATTTTCCTGAAATTGTACAA +AACCATTAGAAATTGAAAGGCTCCTCAGTTTAAAGGCACATGAGGTTTTT +CGGAGTGGGTGGCAATTGTCGTTCGGCAAATTTTTTGGTCGACAAATTCG +ACAAATTGCTGGTTTGCCGATTTGCCGGAAAGTATTTTCTTACTTTTCAA +AATATATGTACGAACATTCAGAGGATGCTTACAATTTTGCCGGATAAAAT +TTAAATTCTGAAATTTCCAAAAAAAATGTGCAAAACCATAAATTGCCAGA +AATTTTTAATTCCGGCAATTTGCCGATTTGCCGATTTGCCGTAAATATCA +ATTCTGGCAAATTGAAGATTTGCCTTATTTGCCGACTTGCCGCATTCCCT +GATGTAGGCATCAAAACGACTGAACACCAAGTTTTTTTGAAATTTTTTAA +GTTTACCTTTATAATTTTTAGTGCTCAAAAAGTTCCAAAATTAAATAAAT +TTTGAAATTTGCCGAGCTCGGCAAACGGCAAATTTGCCGCACACTCCTGT +TTCAAATGTTCACCGCATATTTAATTATTCCGGAAATCCCCTCAAACATC +CATCAAAAGTGTTTTCCCTGATTTGTTGACTCTGACACCGACGGTGGTTG +TTCCCCCCCCCCCCCACTCTCTCAATTGGCATGTAAATGAGCCCGTATGA +ATGAAGTGCCTTTTGGCGGCAAAATGCATATCTCCAAGTACCATTGAATT +AATCTTCCATCCCCCATTGTCTCCTTCTATATAGGGGGGAGGATGCGTGA +TTCTTGAAATATGCTCCAAGTGACAAATTGAGCGTGTGTGATGTATCGTG +GCAGATGGCTGGCTGACAACGGATCAGTTCCAAAAACTGTATCAAACGGG +GGGAAGAGAGGGGAGATGAAGGATGGGGGCAGATGGAGTCATCGATGCAC +CATGTTTTTTGGAGCTGTTCACTCAGATATTAGGGTATTTTAATCCCCTT +TTTAAGGTCTATTTCTGATCGTAAAACTTGGTATTTTCAACTCATTTTTA +ACTCAAAAATTTCAAAAGTTTGAAAAATTACACAAAAACCTAAATTTTGA +TCTGGTTTCAGGCATTTTAGTCCCTGTTAAGCGTCTTCGATGCACCATGT +TGTTGTTCAACTTGTTTAAACTTTTTAGTTCCGCATCGAGGAAAATGGAA +AATAAAAAATTATTTATGTATTCAAAAACCATACTTTGATTCTCCGTAAC +AACGCTTTCATGGGAGGCAGGCCCGGTTTCAGGGCCTGACGCCTGCCTCA +AACCTGCCGGCCTCACGCCGGCCTCACGCTTCATTTCTGCATTTTGGCGA +AAAATCAAATACTTGGACATAGTGAAAAGGTGATTTTTTCGACGCGGCCG +ACACTTTTCGGGTTCCGCGCCGCACTATACAGGAGGCGAGGCTCGCGGCG +CGAGGCAGGCGGAGGTCGCCGCAAGGCAGGCGCGGCAAGCATTTTTGTGC +TTACATGGATACCCTAGTCTACACAAAGCACGAATTTCTGGCTTCCCTCA +TAAATTGAAATGGAAGAGTTTTTGCCGAACTAGGCCATTTTGGCTCGGCC +ATATCTGGGGTAGATTTGCCGTCGCGTTGCGTGTCGCGTCGCGGCTCGAT +TTTAGTTGTAAAACTAAATTTATTTGTCCGTGTGGAGTACACGACTTTCC +CATGCGTTGTCCGGCGGGCGATTGTCAATGGAGCGCAAAAAATTCAATGA +GAAAGGCCAGAACCCAGTGAAAAAGATAATTTGACAATTACAAATAATGT +TTTAAAATTTTTTTTTTGTTTTTGATTTTTGGTTCTCCTTGTGTTTTAAG +AACATGATGCATCACCGCTGGAAATTGCTGGATATGTAAAAAAATTATTT +ATGTACATATTTAAAAATCAAATCTTGATTCTCCGGGATAGAAGCATAAA +TCAAATTTATTACTGTAAATTTTCACTTTCAGTACATTTAATTGAAATTT +TTAAGCTTTGAAGTTCAGGGTATCATAGTTTTGCCTCCAAAATCCACTTG +CCCAAAAAACAAGCCTGGGAATTCCCGGCGGGGGACGATGGTTCGATAGC +ATCAATCATATCTGTGTGTGTGTGTGTGTGTGCAAGGCGGGGGATGAGCC +GGCGCGCGAAACGAATAAATCAAGAAACGTCTCTCTTTCTGCGAGCACGG +ATTTTGTTGTGAGCCCGCGCGCGCGCGGTCTATAGGAGGAGAGGGGTATC +ATGCACTTCTAATACAGGGCATACTTCTTTCATTTCCATGTTTTTGTACA +TGTAATAAAATTGTTAATTAGCCAAAAGTGGTTCACATGTTCACGTCGTA +AACGTCGGTTTTCAGGGTGTACTGATAATGAATGTGCTCTGTGTGGAGAC +AAAGAGGCAGCAGAGAGCAAGAATCAGTTAGGTTAGGCAGGTGACTTTTT +TCAATTGTGACTAGGAAAAAGTATTTTGGGAATTTTTTTTTATTTTTTGG +CTTCTGCCCAGATTTTCAGGATTTTTCAAATATTTACAGAAATTTTCGTG +ATTCTACAATAATATTTTTGTAATTTTCTCAATTTTCAAAAAATTGCCAA +TTAATTTTGAAGTTTCGAATGAAGCAATTGCCGAAGTTGCCGACTCCCGG +AAATTTCGAAAACCGGCAATTGCCGAAATTGCCCTTTGCCGGAAATTTCG +AAAACCGGCAATTGCCGAAATTGCCCATTGCCGGAAATTTCGAAAACCGG +CAATTGCCGAAGTTGCCGACTCCCGGAAATTTTGAAAACCGGCAATTGCC +GAAATTGCCGACTCCCGGAAATTTTGAAAACCGGCAATTGCCGAAGTTGC +CGACTCCCGGAAATTTTGAAAACCGGCAATTGCCGAAATTGCCGATTGCC +GGAAATTTCGAAAACCGGCAATTGCCGAAATTGCCGCTTGCCGGAAATTT +CGAAAACCGGCAATTGCCGAAATTGCCGATTGCCGGAAATTTTGAAAACC +GGCAATTGCCGAAATTGCCCATTGCCGGAAATTTCGAAAACCGGCAATTG +CCGAAATTGCCGCTTGCCGGAAATTTTGAAAACCGGCAATTGCCGAAACT +GCCCTTTGCCGGAAATTTCGAAAACCGGCAATTGCCGAAGTTGCCGACTC +CCGGAAATTTCGAAAACCGGCAATTGCCAAAATTGCCGATTGCCGGAAAT +TTTGAAAACCGGCCACTGCCGAAATTGCCGACTCCCGGAAATTTCGAAAA +CCGGCCACTGCCGAAATTGCCGACTCCCGGAAATTTCGAAAACCGGCAAT +TGCCGAAATTGTCGATTGCCGGAAATTTCCGATCCCTGAGTTTAGCCTTT +TTCAGCAAATCAAACAGTTTATGATTATTTTTTCAAAAATTGTTCTGCAG +TGCTCTTGCATCACTATTGTGGCCCTCCTTTAAATACAGTACTTTCTACA +GTACCACTACATCAATGATCCTTCCAGTAATGCCAACACATTGTACCACT +ACAGTAATCCTACAGTACCCTATACAGTACCGTCGCAATACAATTACCGT +AACACTATGGAAATCTTACAATAGACTACAGTATACAAAAACTACAGTAA +CCCCCTTGAAGTTAGTGTAAAACTTGCAAATGTTCAACTCTTTTTTCTGA +TTTTTTTTTGTTAAGTTCAGAAATTGTAGAGTGTTTTTGGCTTCTGCTCA +GATTTTCAGAAATTTTCGTGATTCTATAGTAGTCTTTTTGTAATTTTCTC +AATTTTCAGAAGTCTGCAAATTCAATTTGAAATTTCGAATAGCTTTAAAA +AACTCAAACAGTTGGCACAAATTTTCGTAGATTCATGTAGAATTTCAGCC +TTTTTCAGCAAATCAAACAGTTTTTTATTTTTTTTTGTATTTTTTCAGAA +ATTGTTCTCACCCTCCAAAGTACTATCACGTCCTAACAGTAATATTAGCC +TACCGTATCACTACAGTAATCCTCCAGTACTTCTGTGCATGCTACAGTAC +CCTTGCATCACCATAGTGGTGATCCTTTAAACCTACAGTACTTCTACAGT +AGCACTACAGTACCACTTCAACAGAATCTTTCCAGTAATATCAGCGTATC +GTACCACTACCGTAATCCTACAGTACCGCCACAATACTATTACCGTAACA +CTATGAAAATCTTACAATACACTACAGTATACAGAAACTACAGTAACCCC +CTTGAAGTTGGTGTAAAACTTGCAAATGTCTACCGTAATCCTACAGTACC +CCAATACAGTACCGCCGCAATACAGTTGGCATAACACTATGAAATCTTAC +AGTACACTACAGTATGCAAAAACTACAGTAACCCCCTTGAAGTTGGTGTA +AAACTTGCAAATGTTCAACTTTCTACAAATTTGCCATTAACTTGTAAGTT +GGGGGAGCGCATCGAAGTGTATACATATATGTACATGCCAACCAATTATT +TTCTCAAACAATTTATTAATAGTCGAAGACACCTGAAGCAACGATTAGGA +GGAAGAAGAGGAAGGAGAGATTGGCAGAAGAAGAAGAAGAAGACGAATTA +GTTGAAGAATCTGTTGAAACGGAAGACGTTGTTTGTGATGTCTCTAGCCG +TGCGACAGCTTCCCGTTTCAGACGGAACGATGTTCGCACGGCGATCGGTG +GCGAGATGTCGGACACGTCGATTGTCGACGAGAAGGGATCAGAGACGGTT +GAAGAATGCTGAGGAGGAGGATTATGTCGACGTTCCCGTCCACGACACGC +GGCCTGGGTACACGTGACACAGACGTGAAGGTTACAGAAGATGTTCACCT +CGTTGCTGGAATAATAGTCGTTGAGAGGTGGGTGGTGAACATGAACAAAG +AACTTAAGAGGCTTACCTCGTTGGGAATGCCCAGGCCTTTATGTGGTTGT +AGAAGATGGTCTTACCATTGCGTCGAGTCACTTCAAAGTCTCCCCACACC +TGGAACAATTTTCTATGGAAGTCTCAAATAATATGCAGTTGGTCGATGCA +CCATGATGAATTTTGTGCCAAACATGGTGCATCGACGCTAAATAATTTTC +TTTTGAAATTTAAAGATGTTTTGCTAGACTTTCCCTAAACATCTTTTTAG +TTTTCCAATGTTCTCTAATATCATCATGGTGCATCGAGAAAAAATGTTAT +AGGAGGAGTAAAGAAATTTGAGACTTTACTTTTTTAGACCAAAAATGACC +CAAAACTACCGAATTGTTTAGTAAGACGTTTTGAAAATTTTTCAAAACAA +AGTTATGGCGGTTCAAAGTTCTGGAAAATAGCATATTTTCAGCTAAAATC +TAATGTTTTGGGGGCTGGGGGAGGAATAAAAATGTAATTTTTTTTGTGCC +CCACTGCCCGAAAATGCACTTTAATCGACGAATAAACGGCTTATAAAGGG +CCACAATATTTATAAAAGAGTGATATTATAGTTATAAATAAAAATTGAGT +TCCCGACCGAGAAAAAAATTGGCGAAAATTTTGATTTTAGCTGAAAATGG +GACTTTTTTTCCAAAACTTTGAGCGGCCATAACTCTTTTTTGAGAATTTT +TCAAAACGTCTCATTTAGAAATTCGGTAGTTTTGGGTCATTTTTGATCTA +AAAAAGTAAAGTCTCAGATTTTGATACTTTCTCGATGCACCATGATGAAG +AGAAAAAAAGAGAAAATTTAGAAAAAAAAAAAAAGAACCCTTCCGATGTT +TTGGGAAAGTTTAGCAAAACAATAGATTTGTAAAAAATTCAATTTCATTA +GGTTCCTATTAAATTCTCAATTTTTATCAATGCACCATACATTTTCAGCG +TGAAATTTTGTAAAATGCACAGGAATGAAAATTGATCAGGTGTGTATAAA +ATAAGAAATTGAAGCATTTTGTTTTTTTTTTTGTCGATACACCATGATGA +ATTTCACGTCAAACATGGTGCATCCTGGAAAGGAGAGAGTTTTAAAAATG +TATCATTTTTTTCTCGATGCACCATGAAGATTTATATTAGTAGAACTTAA +ACCGCACTTAGCATAAGTGGCATAAAAATAAAGGTGGAGTAGCGCCAGTG +GGGATTTTGTCTAAATACACTTATTATGATCCAAAACGATCGAATATCTT +AATGAAACACTCCAAAATATTTAAGATTTTTCAAAATTTCCGGTCAAAGT +TTTGGCAAATTGCCAAAATATTGAAAAAAAATATGAGCTTTTGAGGAAAT +CCAAAGCAATGTCGCGTGTTTCGACCCACACAATGTTTTTATACAATGTA +GAAAAAAATTTTTTTTTGGTCGACTTTTAAAATTATGAGTGGCAAAAACT +GAGTAATTGCCAATTTGACAGTAAATAAAAAATTTTCAAAAACATTTTGA +AAAGTTTTATTATGATATTCGATTATTCTGGCACCATTTGAGTGGTTTGT +AGTAATTTCCCCACTGGCGCTACTCCACCTTTAAAATTAAAAAAAAAATC +ATAATGGGTATTTAATATCAATGAAAATTATCGATTTTTCCAAATGTATC +AAAATGAGTGTTCAGCGCGAAATTTTGTGCAGGACTTTTTCTTTCAATAA +TATATCCCGAATGATGCATTAGTTATGGGCTACACGATTTTTAGAAAAGC +ACCTGGCCATGCTTAAAGGTGGAGAACCGAAATTTGATACTCTGTCTTTT +TAGATCCAAAACGGTCCAAGACTACCAATATTCGTATTAACCTGTTCTGA +AAAATTTTCAAAAAAAAAAGTTATGGCCGTTCAAAGTTTTGGAAAAATGG +TCGATTTTTAGCTAAAATCTCAAATTTTGGCAACTTTTCAATGTCACAGC +TGGAGCTTAATTTTAGAAACAACACGTGATAAATTGCAAAAACATGCATA +AAAATATGTTCCAACCGCTCCGACACTAAAAAGGTGCCAAAATTTGAGAT +TTTAGCTAAAAATCGACCATTTTTCCAAAACTTTGAGAGGTCATAATAAC +TTTTTTTTTTGAAAAATTTTCAGAACGTCTTAATACGAAATTTGGTAGTT +TTTGGACCATTTTGGGTCTAAAAAGGCAAAGTATCAAATTTTGGTACTCC +ACTCACTATCGAAGCAGAGCCCCAAAAGTTTGACCGACCCAATTTTGTAA +GTTTCTTCGATGCACCATGATGATTTTGAGCAAAATGTTAGTTTTTTTTT +TTGAAAAACTGGTGGCAGGACCCAGTTTTCGGCAGTTTTAAATGTCGATG +CACTATGTTTTTTTTAATGAAACCGTACCTCCCCAGAAGTCTGCAAAGAG +CATCCGTGTGAGTCCGACAGTGGTAGCTCGGATATCCCGTCATTCGCCCA +ACACCTTCCGATTCGTCCATTCTGATCATCGCTCATTTCAACTGTGTACG +TCTACAATTTACAAATAGTTTCTTTTGATTTATGGAGTTCCTGACTTACA +ACTCTATCACCAACTGCTAACGGACGTTGTAGCTGCTTTGAATCCAAACT +GTCGCCGTCTAGAACACGAACTCGGTAGTCGACTGTCTGAAACATTATAT +GGGTCTCGCAGCGATAATTTTGAAGCCTTACCTTATTATCCGATAGGCTG +CTTGCTGTGGTGGCATCCGAGTTGATAGTGATTCCACCAAATGATACGGT +CACCTGAGATTCTTTAGGAACAGGGGCAGCAGGTATACAGGTCAGAAGGA +ATCGTTTGTCGGTTTCTGCATTGAATCTTAAAAAAAAACGATGAGGAAGT +TATTTTTTATTTTTGTCTATTTTTGTTCGTATATGGTTTTTTAGGTACCA +TGGAATAAAAAAAATGCTCCTAAAAAAATTAGTTTCAATAACAAATATTA +CTGGTACAGAGAGTGTAGATAGTTAGAGAGTGACTGACATCCGGGACCCA +ATGGGGCGGGGCGCGCGGAAGAGACGATTCGTGTCGATTTACGAAATGAT +GACAACGAGGAAAATTTCGTAAATCGACACAAATCGTCTCTTCCGCGCGC +CCCGCCCCATTGGGTCCCGGATGTCTGTCACTCTCTAACTATCTACACTC +TCTGTACCGGTAATACCATAATATGATCATCATTCTACATTAGAAAAAAA +TCGATCTGAAATCACAGATTTTTGGCCTCCCTCATAAATTGAAATGGAAG +AGGTTGCCAAACTAGGCCATTTTGGCTCGGCCATATCTGGGGTAGATTTA +CGGCGCGTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAAAT +GTAGTTGGCCGTGTGGAGTACACGACTTTCCCACGCGTTGCCCGACGGGC +GATTGCCAATGGAGCGCGAGAATCTCAATGAGGAAGGCCATGGCGCGCCA +GAACCCCATGATTTTTAGGGTATTTCGAGGTTGGCAAATATTCTGGAATC +TTTTTGCAAAATGTTTTTTTTTTTTTGAAAAAAAAATTCCAAAAAATATC +CTGATCGATGAAAATTGTTGGGTGAAAAAAGTTGCAGATTTTAGGAGAAA +TTTGAGAAATTAGAAAAATTAGAAATTAGGAGAAATCAGAAAATTTCCAA +ACTGCTTTCAGAATACTTGTATATATTGAAATAGCCTAAAAATCATGAAA +TTTTTCAAAAATCTCTAAACTAGCCTCCAAATTTGGTAGTAAAAATTCAC +TGGCAGCAACTTCAGAGCGAGATTTTTCTAGTTTAAAGTGCTCGTATGTC +GCTGAATTTTTTGTAGGTACCTATTTGAAAGCTCTTTTTTCAAAATTCAA +AAATTTAATTTTCAAGTTTAAATTTTGAGTAGCGCCAGTGGGGGATTTTG +TCTAAATACACTTATTATGATCCAAAACTACCTGAGTAATTGCCACTTTT +TGACAGTAAATAAAACATTTACAAAAAAAAAAAGTTTTATTATGATATTC +GGTCACTTTGGGACCAAATGAATGGTTTTTCATAATTTCCCCACTGGCGC +TACTCCACCTTTAAAACTGAGCGGAAATACTTTCCTTGTGAGCATAGCGG +CAAAAAACCTAGTACCACATGGCAAAAAAAAACCCACTCATTGTTAGCCA +TGACAACTTCGATCTCATTCTCCAAATTGCCTTCTCCGTTCTCCTTGGTC +GAGCAGCCAGTCAGCGGAATCTAAGCAAATAATGCCCAAAAATTCAATAC +ATTCAATAGGCAAACCTTCAACTGATATTTGGTGTCCGATTGAAGCGTGC +CATTTGCATAGATACACTTTGGATGGCCCGCGCGACTTTGTATCGTGCCA +CGGAAGTTTTCGTCAAACTTGATTTTCAATAGGAAATCTGTCTGCAATAT +TGAAGACGTTTTTTTCCTTTTGGGTGGTGACCTTCAAGGTTTTGGCCTGG +GTTTTTAATCTTCCATTAAATGCCCTTCAAATTCGCTTTTTCGAGAGTTT +AAGAGAGTTTCTAGGCCGAGGAACTTCTTGCAGCCAAATTTCTAAACTAT +TGTGTTTTTGCCAAAAACAATGAAACATTTTAGGTCATTTGTGACGTCAT +ATTTTTTCCATGCAACTTTTTATTGGCTCCACACATCTTCCAAAAAGCCT +AAGCCTGAGCCTAATCCAATGTCTAAGCTTAAGCCTAAGGTTCAGCCTAA +GCGTACGCCTAAGCCCAAACCAAAGCCTAAGCCTAAGCCTAAGCTCAAGC +CTAAGCCTAAGCCTAAAAAAAACCGGAAAATCCTAAGCCTAAATAGCGTC +AGTAGCAAGCTAACGCTCGCCACTGACGCCAAACCTAAGTCTCGGCTTAA +GCCAAAGCCTAAGCCTAAGCCTAAACCCATGATTAAGCCCAATCCTAAGC +CTACGCCTAAGCTTGAACCTAAGCCTAAGCCTAAGCCTAAGCCTAAACCC +AAGCCTAAAATTTCTAGGCCACCACTAATATTTTCAAAACTCGATTCTCA +AATACTTCATTTTTTCAGGATATGAAAGTAGGACAGAAATGGGCAGGGTA +TATGGTATGGAGCAAATATCACAAGATGGCAGAAACATAGATACGGGGTG +GGAGTGTTGGACTAGGTGACTTTTCTAGGCCATCCCTACCTTATCACACG +CAATAGAAGTGTCCACAATGGCCACCGATCGAATCAGCGGTGGCAGCACC +ACAACCACCGACCAAATGATCCAGTGCAGAATCATAAATTTGTGGAGGGA +AAAATCGATAACAGTAGTGAGGGTAATAGTAGTAATAATACAAATATATA +TGGAAAAATGAATACAAAAAGATGTGTGCGCTGGTTGGGGTGGTGGCGTA +AGAATACAGGTGGGTGGGGGGTATAATTGGAGCGTGGCCGAGGAGGAGAA +TCGCAAAAAAAAGAAGGAAAGAAAGAGGATAGTAATGACATGTTACGGTA +GAAGGACAACTACCTAATTATATGAAAGAGGGGGGGGGGGCGACGAGAAG +AGGAAAAAGTCTTACGCAATTTGCTACTCGACTTTCAATTTCTGCTAGAA +ATCGAAAAAAAAATAGGAAACAAATTCCGACTCTATTCGATATCATCACT +TCCGGGGCACGGCACAGGTCGGATCAGATTCAACGACGTCTCGCGATCCC +GACCCTCTGATCTTACGGCCATCCCATTGTTCACATGATAGTCGATGAGC +TCGGAGATGTTGCTGAACGTGCGATCGCGGGTTCGGACTCTCTGGAATTT +TGAGAGGTTTGAAGGTTTGGCGGGGGGGGGGGGGGAGGGTCTTACGTTGT +GATTGTCCAGTAGGATGAGATGTTTGTGCTCGTTTTCAGCGGTTCGGCCA +CTCAGCACGTACTTGCCGGGCGTGTGGTCGCTTTGTCTGCAAGGAACTGG +ACAAGTTTGAGCGGCCGACAGCTTGCGGGTCTTTTTTTAGAGAAGGGGGA +CTGTGAGGTGTCCGCTGCTTCAGACAATCTTAGCATCATGCAAACCTTGC +ATCTTTTGTATTTCAGGAAAAAAAACGCAGAATTTTTTTTGAACAAAAAT +TTCAGCCTAAAACAAAAATCTAAAAAAATTTTGGGAGGATGAACTTATTA +TACCAAATTTTTCCCTGGTCTTTCAAGAATTATTTAAAGTCCCGTGGCTT +CTGAACATATTATCAAACAAATTACAGATATGAAATGTGACTGAAGCTTT +AAGTCAGAAATATATAAAAAAAGGATTTTTCATACTATTTTTTCAGTCAA +ATTTGATTTTTTTAGACTTTCAGATTTTTCTACGAAGTCTGTTAAAATAG +GCTTATATTAAAAAGCTATCCGATTTACTATTAGTAAAAAATTATAGCGA +CCGACATCTCGCAGGTTGTTAAAGAAAGGTGCATTGACCGGCTCACGCAA +CTTTGGCAGTTTATATCTCGGCTGGTTTTGGTTTTATTTAAAAAATTTCA +ATTGACGAAATATTTATCACTTTTTCTACTAAAAGTTTGCAGTTGAACAC +TTTTTGCTAGCAGCGATATTAACCGAGATATTAGCGGAAAAAGTTACATG +AGAAACATGGTGCATCGACAAGAAATATCTCACAAAACTTTGGCAGGTTA +TATCTCGGCTGGTTGTGGTTTTATTAAAAAATTGTTAATTAACAAAATGT +TTATCCTTTTTTCTACTACAACTTTGCAGTTCAACACTTTTTGCTAGCAG +CGATATAAACTGAGATATGATTGGAAAAAGTTACATGAGAAACATGGTGC +ATCGACAAGAAATATCTCACAAAACTTTGGCAGGTTATATCTCGGCTGGT +TGTGGTTTTATTGAAAAATTGTTAATTGACAAAATATTTATCCTTTTTTC +TTCTACAACTTTGCAGATGAACACTTTTTGCTAGCAGCGATATAAACCGA +GATATGATTGGAAAAAGTTACATGGAAGACATGATGCATTGATCAGCTAT +CATAGCTCATATTTTACTTATCTCAGGTTTTACCAAAAAATTGCCAATTA +TTAAAACATTAGCCTTTTTCTTCGAAAATCAAATTTTGCCCGAATTGCCG +AAAATATAGATTTGATATTTTTTTGTAGATTTAGGAGCCTAAACATTTTT +TAATTTTTTAAGTATTGACCGTTTGCTTTTAAAAATGACTAATCGAATAC +TGAAAACACAGTTAACTTTTTTTTCAATTTTCGAATTATAATTAGGTTTG +AAAATTGCCGAAAATGTCGGCATTCAGTTGGAATTTTGGCAATTGCCGAA +AATTTCCGATTCCCACGCGCCCCTGGTGTGAACCTAGTGAGCATGAAGCC +AAACGTTTTAGAAATTCAGCAAAATTCTAGCTTTTTTCTATAAAAAATCT +AAAAAACCTTACCGAACCAAAAAATCGCCTTCCGTCTTCAACAAAGCCTG +TGCATCCTCTCTGGATAAATTTCCATGATACCAAACTTTCCCCACAACAT +CCTCAGTTACAGTAGGTGCTCGGCAATTCGACACAAATGACTGTCGATGC +AGGGAACTTCGATGTCTCATCGGCGGCGCCGGCACCGTAAATCCATCGTT +AGAAGTTGAAGCATTCGCCTGTGCATCAAAAGTGTTCACATTGATCGCAG +TGGTAAGGACGTCGATGAGCTTGTGCACATCCTCGATGAACACCACGTGG +CATCGACGATCCGTTCCATCCTTGTTTTTTGCAATGTAGCCGAACATTAG +CTCCGTGTCCGTACCCTTTTGGCCTTGGGCTCCGAATGAGAAGAATGAGA +AGGGATGACGTTGAATTAGACGACTTTGTTTTATGATTTTGATCATTTTC +GAGGAAATGTTGATGTCTACGGGGAAGTTTTCTTTTTTCACTTCACCGAT +TACCTGAAAATAAGGATGGTTTACCTGGGCTTTTTCATCGACCCGTGAAG +TGTCGGCTGCAATAATTTTAGTCGAAATTAGTGATAATAACTTTTCTATG +AATAGCGGCTGACATCATTTAGCGCGATTTTTGATCGACCTGTAAGATGT +CGGTTGCTTTAGTACATTCTATAGTGGCAGGCTTTTGGCTGAATTTTACT +GGATATATAAGCTATCAAAATTTGAGCATGTCGATGCACCATGTAATTAT +CTCAGTTTATTTCGCTGCTATCAAAAAGTGTTAAAATGCAAAGTTGTAGT +AGAAAAAACGATAAATATTTTGTCAATTGACACTTTTTCAAAAAAAAACC +AAAACCAGCAGAGATATAAGTAGTCAAAGTTGAGTCAGATATTTCCAGTC +GATGCACCATGTAACCTTTCTCTAATAACCTGTGAGATGTCGGTTGCTAT +AATTTTTTAGTCATTAATTTGGACAGCTTGTTAATTTGAAATAATTCTTG +ATGATATCGTAGCGCGGCCGACATTTCACGGGTCCTTTTTTTTAAACATT +TTGCAAAGCTGGTCATGCATTTTTGGTAACACTTAATATCAAATTAATGA +GAAAATGTTTTGTAAATTTTTACCATTAGCCATGCCCAGAAAATGGCAAG +TTTTTTATTTTATTTTCTTTTGTTTTTTTAATTCACAAAAAAAAACTCAC +CCTACTAACAACTGGATTGATTTCTCGAGCCGCAGTCACGCCAACAGTAG +CTGCAACGTGTTGTATACATTCTCTGAAAATTGAACAGTTACTTTATTAC +GTAGATTTTTTATATATTTGAGCTTGCAGATGTTACCTGCCTTCATGCCT +GCCTACCGCCTGATTTCTAAATTTTTGAATAAGATTTTTTTTTGATTTTA +AGCCATAAGAAAAACTAACGAAACAACTTGAACTCTCATCTCGGAAACCA +TCACGTTAATTGACTCGACTACTGGAACACTTCCGAGGTACTGAAAGACA +ATTTTATATTTTCGGGGAAAAAACTAATAAAAAACTCACAGTAGCCGACA +GAGAAACCCCGCTGCTCCGCAGCTCCTCTGCAAATGAGGGCTCCACGTTG +AGCATCGCCGCAAGTTGATTTTTCGACGGAATTTTTGATTATTTTTAGAA +AAAATCTAACTCGAAATTCGTTACAACCGAAATTTTGCAAGATTGAGTGA +ATGAGGAATGACCGGGAGAGAAACGGAGACGCAGGCGGTGAGCGGAGTGG +GAGAGAGAGCGCGCGAGACGGAGAGGCGCAGGCAGTGGTAGGGAGGAGAC +AGGGAAAGATTAGATTGGTGTTGACTGGGTGAGTCAGCATTCTAATAAGT +TAAGTTGACTCATAACTTTGTTTTTTGATCAGAGGGGGGGGGGGGGGGCC +GTGGCCTAGAAATATCATTGCCTACTTATTACGTCACTAATGGTCTAGGA +AACCTTGATAGCTTTTTTGGAGAAGATATGACGTCATTGGTGGACTAGAA +ATCTTATTTTAGTTCTGGAAGAGAAATATTTTGACCGTGGAAGACAAATT +AATGATGTGACCGGTGGCCTAGAAGTTTCAAATTATACCTGGGGAAATAA +ATGACGCCACTGGTGGCCTAGAAAACTTAAACTATGCCTGAAGACGTCAC +CGGTGACCTAGAAATTTAATTCTGGCGACGTCATAGAAATTTGAATTTTG +ATGAGAAATATAATTTTATTGGTTTTCTGAAAATTGAATTTTATTGATTT +TTTGGCAACCGGGAAATTGGAAAATTTAATAAATTGAACAAATGCAATAA +AATAAGCAGTTTTTCAACAGTCATTACTTTTTTCCGTGAACCGTTTTGAT +TTTAATTTGTAAATCTAGGTCGGAAAAGTCACACACACCGAGGAGCTAGG +CTTCCCTCATCCTCCCTGGATCAGTCGGTAACTGCTTCGACTGGGGAGTG +GGAGTGGGAGGGGTGGGATGAGTTCAATTCTTCTGGAATTCCATAATTTT +TATTTTTGTTTTTTTGCGCCTACATATACCTGTGAAAATTGGAACTCGAC +ACAAAAACCTCTCTAGCGCGGCTTAAATTTACTTCAATTCTTCCGGAATT +CCATAATTTTTATTTTTGTTTTTTTGCGCCTACATATACCTGTGAAAATT +GGAACTCGACACAAAAACCTCTCTAGCGCGGCTTAAATTTACTTCAATTC +TTCCGGAATTCCATAATTTTTATTTTTGTTTTTTTGCGCCTACATATACC +TGTGAAAATTGGAACTCGACACAAAAACCTCTCTAGCGCGGCTTAAATTT +ACTTTCCTGTCCCAAAAACTCATCTATAATATTTTTAAAAAATCTAGAAT +CCAAATCTATCAGATTTTTTTGAATTTTTGATTTTTTTCACATCGAGATT +CGGAATCAGCGGAAAATTTGGAGTCAATTAAAAATATTTTCCAGATTTCG +ATACTCCACATTTAAAGGAGATCACCTGAAACGCCAGAATATGATACTTC +ATACTCTCCATCTTCTCGCTTTTGAAAATAATCAAAAAAAATAGTCGCCG +TATTTATTGATATAGAAAAAATACCAACAAAATTGTAACTATTGATTAGC +CATACAGGGTCTTTAAAGTCAACATTCATAGTGGGAGCTGGAAATAAAAA +TATATAATAACTTGTTAAAAGAATTTATTGTGGAGTTATAACACCTATAG +ACAATTAAAATCACCTGCTGCCTAAAGAGTATTTACCAGAAGCAAAGGTT +TTCTGAATTTAGTGGAGTTTGTCCATTTACTTTTTTGCATGTTATTGAAT +TGAAATGATACATAGTGAAACTAGAGGTAAAATTATTTACTAGGTTTAGG +CTTAGGCTCAGGATTAGGCTTAAGCTTAGGCTTAGTTTTAGGTTTAAGCT +TAGGCTTAGAATTACCGATAACTGATAACTTTTGCAAATTTAGTTTCTGT +AATATCGGCAATAGCCAAAATTGCCGGAAATTTCTGCGATTCGAATAAAT +AAATTGAAATAAAAATTAGTTCCTAAGATACATGTTATCTTTTTGCAGGA +AAGTAGTAAACTCATGAAATGAGAAATTGCGATGAGGAAGGAAACATTCC +TATGGTTCCTTAGACAATTTCTCACCTTACATTAGTATATAATATATAAA +TGATGAATTTGACTTTTTGAAATTCTCTTCAATAAATACATTTAGTTGTT +TTTTTTTTAATGAGTAAAGTTGCAGAGTGTGGAATTTGCTATGAGGAATA +TGGTGAATATTGTTGGAAATTTTTCTGAAAGTTTTCATTTTTTTTGGAAA +TTTAGAGAGTTGGGTGTAATTACTGAAAATTATGTTTTAAAAAAATTATT +TTAATGATTTTTCAAATTTTACAAAAAACTCATTTTTAAATCATTAGAGG +TGAAGTAGCGCCAGTGGGAAGATTGTTAAGATCCACTCCTTTAATCCGAA +AAGTACCGAATATCATAATAAAACTTTTCAAAAGTTTTTAGAAACTTTTT +TATTTACTGTCAAAAAGTGACAACCACTCAGTTTTTGCCACTCATAATTT +TGGAAGTCGACCAAAAAAAAAATTTGTTTTCCTACATTTTTTATACTTCA +ATTTTGTTTTAATTATTTGTATTGAAAAATTGTAGGGGTCGAAACATGCG +ACAATCCTGTCAGTTTTCAAAAATCTCTACTTACAAAATATAGGACACGC +TCCAAAAATGGATGTTTTTACAGACAACGCCATCCGAATCCCTTGCATCG +GCACATGCGGTCATACGTTATGTGACAGTTGTCGTGAGAAAATTAGAGAT +AAAAAATGTCCTCAGTGTAATCAGAAAGGCGCATTTGTTGTGAAAAATGT +GAATAAACAATTTTGGGATTTAATTGTTTTTTCGCAATTTTTAAAACCCC +AGGAAGTGGAAGTTGAGGAGACTGAAGAGGTTGGTTAGAACTTTTTTTTT +GGATTTTTCGGTATTTCCGGGAGGTTATCCTTTGGGCCTAAAACTAGGCC +TAAGAGTAGGCCTAAGCCTAAGCCTAAAACTAAGCCTTAGCCTAAAACTA +AGCATGAGCCTGAGCCTAAGCCTAAGTCAAGCCTAAGCCTAAGTCTGCTG +CTATCAAAAAGTGTTAAAATGCAAAGTTGTAGTAGAAAAAACGATAAATA +TTTTGTCAATTGACACTTTTTCAAAAAAAAACCAAAACCAGCAGAGATAT +AAGTAGTCAAAGTTGAGTCAGATATTTCCGGTCGATGCACCATGTAACCT +TTCTCTAACAACCTGTGAGATGTCGGTTGCTATAATTTTTTAGTCATTAA +TTTGGACAGCTTGTTAATTTGAAATAATTCTTGAAGATATCGTAGCGCGG +CCGACATTTCACGGGTCCTTTTTTTTTAACATTTTGCAAAGCTGGTCATG +CATTTTTGGTAACACTTAATATCAAATTAATGAGAAAATGTTTTGTAAAT +TTTTACCATTAGCCATGCCCAGAAAATGGCAAGTTTTTTATTTTATTTTC +TTTTGTTTTTTTAATTCACAAAAAAAAACTCACCCTACTAACAACTGGAT +TGATTTCTCGAGCCGCAGTCACGCCAACAGTAGCTGCAACGTGTTGTATA +CATTCTCTGAAAATTGAACAGTTACTTTATTACGTAGATTTTTTATATAT +TTGAGCTTGCGATTGTGTAATCAAAAATAAACATTTGAAGCATGATACGA +AATATTTGAACGATTTTTTTTCGGAAAATCAATAAATGAAAATGGAGTTT +TTTTTTTGGATTTTAGCAAACTTCCCAAATGACGGAAAGATCATATGAAG +CGATTATTTTTTCTTTTATAAACCTGTTCAGGATTTGCATTATTATGAGA +AAATCCTAGGCCAATTAGGCTAGCATGTACGGAAGTATTTTTTAAAAATT +TATAAAAGTAATGAAAAGCTGATATTTTCAAAATTCCAGAATGACGGAAA +AATCATATGAAATGCTTTTTTTTTCTTTTTTAAACCTATTTAGAATTGTC +AAAACTACCAGAAAATACTAAACAAAATAGCTTAGCTTGACCGGAAATAT +TTTTAAAAAATTGATAAAAATAATGAAAAGCTGATATTTTCAAAATTCCA +GAATGACGGAAAAATCATATGAAGCGATTCTTTTTTCTTTTATAAACCTC +TTTAGAATTGTCAAAACTACCAGAAAATACTAAACAAAGTAGGTTAGCTT +AACCGGAAGTAATTTTTACAAATTGATAAAAATAATAAAAAGATGATTTT +TTCAAAATTCCAAAATGACTGAAAAATCATATGAAGCGATTCGTTTTTCT +TTCATAAAATAGTTTAGAATTGGAATAATGATCAGAAAATACTAAACAAA +GTAGGTTAGCTTGACCGGAAGTATTTTTAAAAAATTGATTAAAAAAACTG +ATTTTTAAAAAATTCCAGAATGACGGAAAAATCATATGAAGCGATTCTTT +TTTCTTTTATAAAGTAGTTCAGAATTAGCATTATTATGAGAAAATCCTAG +GCGAATAAGGCTAGCATGTACGAAAGTATTATTTAAAAATTTATAAAAGT +AATGAAAAGCTGATTTTTTAAAAATTCCAGAATGACGGAAAAATCATATG +AAGCGATTCTTTTTTCTTTTATAAACCTGTTCAGAATTGTCAAAACTATT +AGAAAATACTGAACAAAATAGGTTAGTCCTAGGAAAGACTAGTTAGGAAA +GAATTCTTAAAATAGGAAGTTGAACAGAAAATCTGGAAGATCTGAAATCT +GGAAAAAGGAACTCTCAAAAATTCAAATTTTGATTTTAGGAATATATGGC +TGTGTAGTCTTCATAGACAATCAAAATAAATTATTTTAATTTTCAACCAT +CTTTATGCACGGGCTTCTGTCCTTCCTCATTGAATTTTTCGCGCTCCATT +GACAATCGCCTGCCGGACAACGCGTGGGAAAGTCGTGTACTGCACACGGA +CAAATACATTTAGTTTTACAACTGAAATCGAGCCGCGACGCGACACGCAA +CGCGCCGTAAATCTACCCCAGATAAAGCCGAGCGAAATGACCTAGTTCGG +CAAACTCTTCCATTTCAATTTATGAGGAAAGCCAGAAACCCGTTTTTATG +TAAAAGTTCATACTGTGCAGTTAATTTAAACAAATCAAAATTTGGAAAAT +GATTTTTGGCTTTGTGCAAACTGTAGCGTTTTAGGCGTTAAAAATCTGCC +AATGAATAAAAAATTTCTTATAAAATTTTTAAAAAAACAGTTATTTGCCC +ATTCCGTTTTTCAACATTTATCAATTACGGTTCCAGTGATCAAATGCTTA +CACGGAAGTCACTGATGACGTTGACTCCATGTTTGGTTGCGATGTGAAAA +AGGTCGTTTTTTGCCCAAATCGAGAAAGGTCACACACACACATAGACATA +CACAAAACCTTATATAATTTGTAAGATATTTTGTTTGATTCGAGAAAAAA +AAGAGAACAGGTATTCCTGCGGCGTCGTTTTTCTAAACGGCAGGAAAAAT +TGAGAGAAAGAAAGAGAAAGAAAAAAGATGGAAAAAAACAGTTTAAATAT +AATTATTAGGTTTAATTATTAGGGGTGCACCATATTGTCGTAGGGGCCCT +TCTCCAAAGTTTTAAGTTTATCGATAGAGCGTGAATACATAAAGAGAGAA +ATTTGACCTGCAAAAAAAATATATGGTTGGTTCCCATGCCATAAAAAATC +CATGCAACAAATGAAAACAACACCTGCCAAGTGTCCTCCGCCAGTCTAAC +CAAGTTTTTCCCTCCAAATGTTCCGTGACATTGTTGTTTAAGGCTTTGTA +CTTTCCGCAGCCGTCTTATTCTTCCCGAAGTGTTCTCCCTAGATAATCGG +GTTTTTTTGTTGAATCGGCTGGGGGTAATGATCGGAGAAGATATATATGA +AATAAATGAATAAAAAAGGAACACCTTTTGGAGAGGCAATGAAAAAGCAA +GCTATGCAAAGTATTGATCCGTTGTTATGAATGGGCTTGCTTAGGCTTAG +GTTTTTTTTAGGTTTAGGCTTAGGCTTAGGCTTAGGCTTAAGCTTAGGCT +TAGGCTTAGGCTTAGGCTTAGGCTCAGGTTTAGGCTTAGGCTTAGGCTTA +GGCTAAATCTAGGCTTTGGCTTAGGCTCAGGCTTGTGCTTAGGCTTAGAC +TTAGGCTTAAGCGTAGGCTTAGGCTTAGGTTAGGCTTAAGCTTAGACTTA +GACTTAGACTTAGGCTTAGGCTTAGGCTTAGGCTTAGGTTTAGGCTTAAG +CATATACCTAGGCTTAGCCTTAGGCTTAGTCTTAGGCTTAGGCATATGTT +TAGGCTTATGCTTTGGCTTAGGCTTAGACCGTGTGTATATCCGAATGTGT +GTTTTATTATGTTCCTGATTCTGAAATCATTTGTTAGTTTAATATCTACA +AACATTCCAAACAGTCTGTATGTGCTGCCAGGTGGCATTTCCTTAATCAT +CTCAAATATATTTGGTTTCATTTCCCCCCATCGCAAAATCCCTTTCTTTA +CCTGTCATTTCGCCTTTACGTTCAACTTATTTGATTTTGTTGTTTTCAAG +TGATAATCACGATTAAACAACGAATGAAAAAAATAGGTATGGAATTACTA +CGGTATTCTTTTTTGCCTATCCTTCTTTCTCTCATTTTCCTTTTGTCTTC +TAACAAGTTCTGCACTTTTGAGGTACATTTCTTCTCCGATTTGATCAGTC +AAAGCTATTCGGTTTAAACCATCTTCTATTCAATTCTGATGATTACTGTT +AGGAACGAGTGGTCACTTAATTCAAAAGGTCGAACTGTTGTACTAATTGA +ATTGGAAAATTTGTAGGTTATTTGACGTTTATCAGAAATTGAAGATTTGA +TATAAAATTTGGTAAAAATGAAAAATAAAGTTTCATTTAGAGTAGTATTC +TGGCTTCCCTTATAAATTGAAATGGAAGAGTTGGCCATATTGGTTCGGCC +ATATCTGGGGTAGATTTACGGTGCGTTGCGTGTCGCGTCGCGGCTCGATT +TTAGTTGTAAAACTAAATGTATTTGTCCGTGCGGAGTACACGACTTTCCC +ACGCGTGGTCCGGAAGGCGATTGTCAATGGAGCGCGAAAAATTCAATGAA +GAAGGCCAGAACTTCGTGTAGTATTAGCAGACCAGGTTTTCACATAAATT +TGAGCGGTGAAACTAAAATTATGACATTTTTACGCAACTTTATGGGCCAG +AAAATTTTTTTTGGAATTTTTTTTTGAAAAAAATTCAAAAATTTTGATAA +AAATAATTGCCAAAAAGACAAATTTTGAGTAATTTTACTGCCTCTAAGAG +TAATGAACAAATGTTTCCAACTTTTTGCAAATTACTTTCTTAGTTCCCTT +GCAAATCTATATAGATTGAATTTGGCCTAAAACCTAACAATTTAGCTGCA +ATATTGTTACAAAAATTTGGGTACAATAGTGTGTTTATTGAAACATGTGT +TCTTGAAGTTGGGTAAGAACAATTGATGAAGGTTGTACCAAATGAACAAA +AAATGTTTTTAGAGAAAGTCTGAAACATTACCTTATTTCTGATGGTCGTT +AATCAAATTTTACTGTAACTGTTATGAAACCTTGGGCATCGTATTTTCTC +TATTAGTGCAGCCGACCACTTTACTTTGAGACGTTATATCTTGTTTATTT +TAAAGATCTCAATATTTTAATAACTACAAAATCATAGAAAAAGAACCAAC +AAAAATTTTGTTAGTTGACAATTTTTAAATAGGACAAACGATAACTGAGC +TATGAGCTGTCAAAGTTGAACAATGGTGGTGCAATAGAAGGAACTAATAG +AAAAAATACGGTAACCTAAATTTTTATGTTAAAATAAGAAGTAGCGGGTT +GATTCCAGAAGTTTTTTTTATAAGGTAACCATCCGCTGACCGCGCCTCCG +GTATCCCTTCAAAAGGCAAAAAGTAAACTTTTCTAAAACTACAGTAATCC +TACAGTAGTCCTACAGTACACCTACAGTACCTCTACAGTATCTTGACGTG +ATCCTCTACCTACTCCCAACCCAGTACCTCTTCAAAGGCTAAAAAGTCAA +AATTTCACAAACTACAGTAATCTTACCGTACTCCTACAGTAACCCTACTG +AACCATTACAGTAATTTGACATTATTCGCCACCAACTCCAAACCCAATAC +CTCTTCAAAAGCTAAAAAGTCAAAAGTTCACAAACTACAGTAATCCTACC +GTACTCCTACAGTACTCATACAGTACTACTACAGCACCCCGAACATATCC +CTCCACTAACCCCAAGTCAATATCACTTTAAATGACGAAAAGTCAATTTT +TCCAAAACTACAGTAATCCTACAGAACTCCTACAGTACCCCTACAGTACT +ACTACAGTACCCTGACTATGTCTTCCACTAACTCCAAACCAATATCCCTT +CAAAAGACGAAAAGTTAATTTTTTCAAAACTACAGTTATCCTACAGTACT +CCTACAGTACCCCTACAGTACTACTACAGTACCCTGACTATGTCCTCCAC +TAACTTCAAACCAATATCCCTTCAAAAGACGAAAAGTCAATTTTTCTTTT +TTTTAATTGAAATTGTCCGTTATTCCCTATTATGTAATTTTCCAAAAATG +CTGCCAACCTCAAAAACTGTTATGTTTTTGTTCATACACATTTAGCCACC +ACCTGCATATGACCCATAAAAAACCATACTTGACACCTGACATACTTGGT +TTCGATACAAAAATCGAGAACATTTGGCAAACCTGAGTTGTCATTCTATT +GGCTATTCACCATGTGCTCTAATAAAGTAGAACTTGGGAATATGTGTCAA +GGCTGTAAATGGGGGAGTAGTATTGTTAACATATGTACTGTGCAATATTC +CAGATGCCAAGTATACAGATTATCTAATGACAATAGGTAATTTGATTTTT +CAGGTGCTATAGTGCTATATTGTTCCAAATACATGATTTTTTTTTAGAAA +ATTGAGGTGTGGTGTCGAATGTCCCATAATTTTGGATAATCAATGGTCTT +TAGCGAAATCCTAATTTGAAGCCGTTTAAAGCTCGAAAGTGCAATACATT +TACAACTGCATTAGCGTTTTATTTTGCTCTGAAAATGACAAATACACAAA +ATTTTGGATTAAACCGCCTGGTTTTAAAACCGAGCTTAAACAATTTTAAT +TTTACAAATTAAAAAGTAAAAATTTTCTAAATTCCCTACACTAAAATTTA +GCGTCCACATCACTTTCTACCCCTTAATTAATTTTTTACTACATTTAACA +AAAATATTTTGAACCGGCAATTGTCAAAATTGCCTATTCCCAAAAATTTC +CAAAACCGGCAATTGCCAAAAATTTTCAAAGCCGGCAATTGTCAAAATGG +CAGCAAACTTCCAAAACCGGCAATTGCAGAAATTGCCTATTGCCAAAAAT +TTCCAAAACCGGCAGTTGCCGAAATTGCCGAAACTGCCGCAAACTCCCAA +GACCGGCAATTGCCGAAATTGCCGGTTGCCGAAAATTTTCGAAACCGGCA +GTTGCCAAAATTGCCGCAAACTTCCAAAACCGGCAATAGCCTAAATTGCC +GATTGCCAAAAACTTCCAAAACCGGCAATTGCCGAAATTGCCGATTGCCA +AAAATTTTCAAAAAAATTTCAGAAATTGATACATTTTTTAATTGTTGTGG +GAATTTTTTTTAATAAATTTGAAACATATCACATCCTCCTGTTTTCAAGA +AAATTAATTCCTTCAGTTTCTGACGACTCAAATCCTCCTCAAATGCCAAA +TTTATTTTGGGAAACTATACCAATTCTCAACAGAATTTTAAAGGTGGAGT +ATTGCCATTTTGTCTAAGTACACTTATAATAATCCAAAACAACCGAATAT +CATAGAAAAACACTCGAAAAAAAATTTTTTTGGTCGACTTCCAAAATTAT +GAGTGGCAAAAACTGTGTAATTGCCACTTTTTGACAGTAAATTAAAAAAT +TTCAAAAAAATTTTGGAACGTTTTATTATGATATTCGGTTATTTTGGGAC +CAAGTAAGTGGTTTACTCCACCTTTAAAAATTTAGCCGTTATACAAACTC +CAAATATATCCATTATTCTTTCCCCTATACCCTACCCATAACAAAACAGA +AAAATTTCAAATTCGCATCGTCGCAACACCACAGCATGTCCATTTGGAGT +GATGTTCCGAGAGAAAGGTCAAATCGTCTACCTCCTTATTCTAACCATCT +CTATGCCTATATATGAGGCTTTAATGAACGAGCGCCGCCGCCGCGCGCCT +AGCGCCTCCGAGTGTCGCAAAGTGCAACTTGTTTGCCACTTAACCTGAAT +TCTACTGTGTTGTATTATGTGAAGAATCGGATAGATGTAATGTGTAACAA +TAAAAAACCACGACGACGACTGAATATGGAATCGGCTAGGTGGTGCAAAA +GTTTCGGAAAGTTTTGGTACCATGGTACCTGTGTAAGCTCTGTGAATTTT +TGAGCCACGATGGGTCTTGCAACGATATTTCGTCGAAACTTTATTCTCGA +AAGTTTGTTCAATTTAAATTTTCCGCAAAAAACATTTTTTGAAAATATTT +TTAAAAATTTGAATTTCTCAGCATTTTTTTTTTAATATGAAGTTTCCAAT +CCCTCAAAAAAAAATTTCAGAGAACATTTGAATTTCCCGGAAACCCCAAT +TTCTGAGAATTTTTCAATTTCCCTTTAAAATAAAATTTCGGAGAAAATTT +GAAATTCCCGCCAAAAATTTATTTTGAAATATTTGAATTTCCCGGCAAAT +ATTTTTTTTTTTGAAAACTTTGATTTAACGGAAAACCCATTTTCTGAGAA +TTTTTGAATTTCCAGTTTAAAGAAATTTCCACGGGTTTCTGGCTTCCCTC +ATAATTTGAAATGGAAGAGTTTGCCAAACTAGGAAATTTTGGTTCGGCCA +TATCTGGGGTAGATTTACGGCGCGTTGCGTGTCGCGTCGCGGCTCGTTTT +TAGTTTTAAAACTAAATGTATTTGTCCGTGTGGAGTACACGACTTTCCCA +CGCGTTGTCCGGCAGGCGATTATCAATGGAGCGCGAAAAATTCAATGAGA +GGAGGCCAGAACCCCGTGAATTCCAGCAAAAAACTTTTTGAAACTATTTG +AAATTCCCACAAAAAAACAGTTTTGCTGAGAATGTTTGAATTTCCCCCAA +AAATTTGACGGAATACTTGAAATTCAAAAAATGTTGTGAGAATATTTGAA +TTTCACGGAAAACCTGTTTTCTGAGAGTTTTTGAAAATCCCTCAAAAAAA +ATTTCGGAGAAAATTTGAATTTCCCTCAAAAAATTTCGAGAAATATTTTA +AATTACCGGCATATTTGACATTTTGAACTCCCCACAAAAAAATTTTTAAA +AATATTCGAAATCCCGGAATAATTTTTTTCACTATAGTCAGAAAAGATCA +ACTGACTAACTTTTCACAAACTACAGTACCCCGAGCATAACCCCCATTAG +TTTCCGATAGCTACAGTAATCCTACAGTACTCCTACAGTCCCCCTTCATA +ACGTTACCCTGATTACTAAAAAATGCCCTTTTAATGCGTATTATCACATC +TCACATGATTAAGACCAAAAGGGGTGTCCTTCAGATAAATACCCGTTCAA +TTTTTTTTACTGCAAACCAGTAGACTTATCTTTTAGGTTATGAAGAGAAG +ACTAAGTGTAAACAAGGTCGTTGGAAGTGATATGTTAAGAAGTTAACGGC +AAAATCGATGCCAAAACTTTCTGAGCTTTGACTTCTACTGCTCAGCTCAT +TCCATAACCATGAGCTCATCAACTTGCCCTCCCCCCCCCCCCACTATCTT +CCACCACACTTTCATTCCTCATTGTCGCAACAAACCCATCTCCGGATTCG +TCCTTTATATGTGTCACAACACAGGAGTACTCCTTAGCGCGCCAACTTGT +AATACCCCCAGCGACTTGGCCCAGAAACTTTCCTCTAATCGCATCCACAA +TATGGTCTGCAAGTACAAGATTAGCACCCCCCATTGTATGTCAATTTGTC +TAGTTTTTTATTCCATTGAACTATTCCACAATGTAGAAAATTGGGGTTAT +GGTACATCGAAACATGGTGCATCACATAATGGTGCGCCCAAATCATGGTG +CATCGTCAAAAATAAGAATCCGAGTCCTCCCAGACATCCATGTAGGTATG +CACTTTCCCGCCTGTTCCGCATCTAACCAACGATTAACTGAATCTTTACG +ACCCTCTCTCCTCCGAATGATGTTGAAAAATGTCGCGCCAGCACCTTTGG +AGGGGGGGGGGGGGGGGTTAAAAAGATTCCAATCTACCACCTATCTTCTC +CATTTATCTTCAATTTTGCCCCCCGCGCTCTTAGATTAAATGAACTTTTT +TGGCTAAATCACAGCACTTTTTATTAAATCTAGGAACTGCATCTAAACAA +TGCATGTGGTTACAGTTACCGAAAAATGTTGAAAATTTGGGAAAAGTGCC +AAAATGTTGAATCAAGTCAGAGAGATTCGAAGACGCTTCTAGCAATTTTT +TGACAGTTCCTGTCCCCTTTCGGTAGATTTGCGGCAATTCTCGGCAGATT +TACACCCGCTTTTGGCGGTTTTTCGGCAACTTTTAGCAATTTTGGCAATA +CTTGAAAACTTCTATTTAGCAACTTTTAGTCAATTTTCTGTAATTTCTGA +GAACTTCCGATTTTCTTTTACATTTTTTTCCGATGCACCATGTCCCGAAC +GCTCGCGCCACGACTTTTTTATTCATTATAGCAGGTCCTGTTTTGATGCA +CCATTTCCCAAAGAGCCCTGCAATGCTGGCTCATGTCACGATGTACCATG +TCCTGAAATGTCCCACCACGTTCCGCAACGAGGTTTTACTGCCAAATTTT +ATGCAATTCCAAAATATTTTTCGACAATTTTGTTAGCTTTTCCCTTTCAA +AAAAGTTCAAAATTCTGTTCCAAAACCACACCAAAAAGTCGAAGATCCGC +AAAATCTGCACTTGAAACACTATTTGACAACCCCCGTCTCAGGCTATCAA +AAATGCATGCAGTCATATATATGTGCAGCTTGTGAAACAAAAAACGAGAG +GGATCAGGGGCTCAGTGCTCAAGGTAGATGTGCAACTCTATGAAATTGAT +CGGTTATGCATGGCAAGTAAGAGTGACAGGGAGCGAAGTATGATGATGAT +GATGATGATGGTGTGGAGAGAGCGCAACGTATGAGTTATTGAATTTTCGA +GAAAGGTTATCTTTGATGGGGGGGGGGGGGGGGGGGGGCAGTTCATGGTG +CATCGAAATATAAAAACTTTCGTGGAGATACGCTTTTTGAAGAATTTTGT +GACACCTTCTTGGTGCATCGAGACAGTTTTCGTGGCAAGACCTGATTTGG +TTGAAACTCTGAAGCCAAATCGCGCTCTACGATTTTGTGACCAGGCCAAG +GTTTTGGTGGCATGGTGCATCATAGTAAAAATTCAAATCCTGGGAAAAAA +AGCTCTATATATAATATCCAGCCATGGACCGTACCTCCGGCGTGGCCCCC +TTCTGGAGCTAAAAACTAATTTTTCTAAAACTACCGTAACCCTACAGTAT +TCCTACCGTACCACTATTGTACCACTACAGTACCCCGACTATATCCGTAC +ACTAACCCCAACTCACTATTTATCCAGAAGCCAAAATTTCACAGACTACA +AAGACTACATAGACTACAAACTATGAACACACTGAATAAGCGCTTCATAT +ATATAGTGAATGATGGTGAGATCCATGTGACATGGTGCATTGTGACAGGC +ATTTTGGGAAGGGGGCTTTGAGCACAAAACAAAATCTTTAGTTATTTTTC +CGACAATTTCCAATAAAGTGAAGTTTAACAAGGTCGTGGCGTACTTGTTT +CCAGTTTCCTCACGAGTGTTGCATATTATACCGCCAGTAATCATTGCGTT +ATCACATAGTTGACAACGGTTTGATAATGTCACAAAGTGTGGGGGTTTTG +GAAGTGGCATCAAACCAGCATACGATTATTAGGACGTGATGAACTTATTT +TACCTGAACATATTATTAGGTGGTGGAGCTGGGAGCTTAGTATTTGGGTT +TTGAAACAATGCACCATGTCCTAAAAGATGCTTTATTGCTAGGTAGGGTG +CCGCGACTTTTGTATTCATTATAACAGGTTCAGTTCCGATGCATCTGCAT +TTTTTTAATACTGTTCTTATTCTTAGCTCAATAATTCAGGCTGAGGGCCG +CAGGCCCGAACACTTTTGGAAACTGTGGGCCAGCTTTAATCCTATTCCAA +GCAAATTGTTATTCGCTCAAGCCAACTAACCAGATTTCCTCAAACTTTAA +TCGCTCATATCTCAGCTCAAAACCATAGCAGAGACTTCGTTTTTTAATCA +ATCGATCCCAAATTTTAAGGAAATCTCGAATATCCCTATCTCAGGTTTGA +GGCGAAGCCGAGAACCTGCGCAAGCTACCTTTTTGGGCATCCCCATTCCC +GAAAGGCTGGCGCGGCCCTGCCGCGCTAGTCATTTGCCAAAACGTCAAAT +TGGGTCATGTCACGATCCATAATGCCTTGAAGGGTTCTTCTGCAACAGTC +CTAAAAGAAACTTAGCACTCTGGTTGAGGTATAGATGCACCATGTCCCAA +AGGGTCCTGCCATGTTGGGACATGTCACGATGCACCATGTCCTGAAAGAT +CCACGCTCGAAAACTACATTGTTCCGAGTGTTTACCTCTATTTCAATACG +AAATTTCAGCAAATTTTCATCCAAAATCATGTCATTCTAACAAGAGCCTA +TCATGTTGACTATAGGGTCGTGACGACCTGCTCGAGTTCGCCTCGCTCTC +CTGTTATCAGAATAGCTATGCGTTAAGTACGCGATGTATTGACAGTCACG +ATTTAACGCTTCAGTTTTGTAGTTTTGCTGGAAATTTTTGAGTTTTTCGT +TTTTTCTTGGCTCAAATCGAGTTTTGCTTTTTTGACGATTAAATAATTTA +TTCAAACTTAGCGCATTTTTTGACTGATTGTGAGACATGATGCATCGTGA +CAGGGCTTAATCGTGGCGAGACCCTCTAGTACAAAATTCTTTTAAATATC +AGTAAAAGCATTATAATCCATGATTCTATACTTATTTTATGGAATTTTCA +GCCTTAAAAAAATCTGAAATTTACGATGCTAAAATCTACTCAAATTATAG +TTTCAATCCAAAATTTCTCAGAAAAACTAAAATTAGCATAAAAATGTTTT +GTCTGAAATAGCCCTAGATTCAAATATCCCTAACACCCCAAAAAACACCA +ATGTACATCTCCTCTCCGTAAATATGTAGTTTTACAACCGCCTCTCTGTT +GACTGGGAGCCATAAATGTAGATATATTATCTTTCCAGATCGCCTGCCGG +CCCCTCCCACCTGATTGTAAAACTGCTCTTTGCTGTGGCGTTTTATCGAC +TTGTTTTTCTTATATATTCCATTCTACATACCTTAACACATTTTCTTGTA +TATTTTCTATACACTTTTTTAACTATAAAAAAATGCAACTCCTTTTTCTT +CGATTTCTTTTTATGCAAATTTTTTGGCTTAAAGGTGGAGTAGCACCAGT +GGGGAAATTGTTAAAAACCACTCCTTTGGTCCGAAAAGTACCGAATATCA +TAATAAAACTTTTCAATATTTTTTTGAAATTTTTTTATTCACAGTCAAAA +AGTGACAATTACTCAGTTTTTGCCACTCATAATTTTGGAAGTCGACCAAA +ATGTTTTTTCTAGATTTTTTATAATGTAATTTTGTTTTAATTATTTGTAT +TAAAACATTGTAGGACAAGACAGGGCCGCAACATAAGATATTGCTTTGAA +TTTCCTCAAAAGCTCATATTTTTCAGAATTTTGGCAATTTGCCAAAACTT +GGTATTTAAAAATTGTTAGAGATAACTGTATTTAGACAAAACATAGAACA +TTTGTATTTCAAAATAGTTCAAAATTCTAGTTTTTGAAATTTTGCGGCCA +GACTGACCCCCACGATGCACCATGACAAATTGCAATTTTTTTTTCAAAAA +TTGTTTTCCAAAGGGGCGTGTTCCAAACATCTGACCCAAGTTTTCCCGTA +GTTCTTCTCTCCCCCAGCGGGGTAAACACTGCACTTTACGACTCCGCCCA +GTGCTTTTTTTTTCGCAGAAACTGAGAGAGAAAGAAACATCTGCGTCTCT +CTCCCCCAGTACGCTCGTTCCCGCCCCCCACCTCGATCTGCCAGACCACA +CCGACCTGATTCGAGATTCCTTTTCTTATATGTATATGTTTTTGGAGAGG +TGATCTTGTTTTTTTTGTTTCTCCTTTGGTTTTGTTCTCTATGCTCTGAA +CTTTGGTCTCCTACTTTTCTACAGTTTTTTTTTAAATATCCAAATTTTTG +AAATAGAGGGTTGATCTACATGACCCCCATGCTTAGTCTACTATAATGCT +ATATCTGATGTTCCTCCGAATGGCCTGGTAGGTGAAGGCTTTTAGCCCAG +TGAGCCGGCTTACCAAGTCTAGGACCATGGTTCTTACAACTTAAGGCCCA +AAAAAAGCAGGCATCTGGCCTAACTTCCCCCTCACTAAATCTGTAGTAAT +ATATAATTTCTATCATACTCCATCTTTTTTTTCTACCTCTTATCATGTTG +TTATTGAGCAGCAACGCCCTTATATTGTTTGGTATATATATTTGATATAA +AACCTCGTAGTAAATTTTATTTTACACAACAACATTTATTATTTACTTTT +TTCATACTATTTTTTTTTTGCAGAACGAAAAAAAAATGCTATTCACAATT +GAGCAACTGGAGCTCATCAAAAAGCTGCAGCACACCGGGATGTCATCCGA +TCAGTTGCTCAAGGCTTTCGGCGAGCTGGAAGTTCCAGAGCAGCTTCAGA +ATAACAACACAATTGCCGCAGCCCTGTACAGCCCACTCCTGGTCCAACAT +CTCACAACACCCAAATCAGAGACTCCAGTCAAACTCACCGTGCAGACAGT +GCCGACACCTGTGAAGTCAGAGCCACAATCTTCAAATTGCTCATCACCAT +TTGAGCATCCGATATGCTCGAATGCTCCGCGGCCGATTAGGAGTCAGCGA +ACGCCGATGAAGGAGATTACCACACTGGACGATCCGAATGAGCTGGAGGA +GTTTATGAAGCAGGGCGAGGAGGCGTGCATTTTGGATATGAAGACGTTCA +TCACACAGTACTCGTTGCGGCAGACTACGGTAGCAATGATGACAGGTTAG +TTCCCAAAAAAGTGTAGTGGAAGAGTTTTTTTTCTAAAATCTAGGCCGTG +ACCAGAAATAAATCAGAATACATCCCCGGCGCCTAGATTCCTAATCTCTG +CTGTTAGCCACAGTGCAATTGAGTATTACTGTAGTTGATTCCTTCTATGA +CGTCATATGAAATAAAGTTGGCTAAAGGGAAAAGGGGACTCTGGATCTTA +GGCGAGCAATTCTCTGCAGCCGGCACCAGAATCGATCCCCCGGTGCCTGG +ATATCTATCCTTCGCTGTTAGCCACTGCGATATGCCCCACCCGCGCTGAG +ATCGAACCGAGGCGTCTGAATTCCTAGGCGAAGTTGCTACCCACTGCGCC +ATGTCAATCTTCTAAATTTCCAGGAGTAAGCCAGCCGTACATTTCAAAAT +TGCTCAACGGCAACCACCGTGAACTATCGCTCCGTTGCCGTAAGAACATC +TACTGTTGGTACCTGAACTGCCGACGTCATCCCAACAAACTCGCTGCCTT +CCTCGCCGATCCGACAACTCGCCTCGAGACGAATGGAGATGGCGAGCTGA +TCCCACAACGTCGAGAACGCTACGTGTTTCGTCCAATTCTGATCCGAATG +CTCGAATCGTTCTTCACACAAACGCCATTCCCAGATCTTCCACGGCGAGT +CGAAATAGCGAATGCTTGCAATCACGTTCTGAAGATGGATAAGAAAGGTG +TTGGGTTGATGCCAAAGGAGGTGGTCAGCCCTCAAGTCGTTTCGAATTGG +TTTGCAAATAAGCGGAAGGAGTTGAGAAGAAGATCCGCTGAAGCTTCGGC +CGCCTCCACCTCGTCCGCTTCGTCTTCTGCGTCATCGACTGCTAATCATG +ATTCTGTCAGTGTGTCCAGCATGAGCCCTCGCGATGAAGAGGTGAGAGTT +TTAATTTCTCGGCCACGCTGTACTCTGGGTGGAAGAATTTTTTCTAGGTC +TTATAAGGAATCGCCCTCCGGTTTTCCCACAAGTTAAGTCATAAACATGT +ACCATCTAGAGGTTAAATTTCTGGAGTTTTATTTATTTGAGAGTGATGGT +AAACCTGTCAGTCCTTGGCAAACATGTGTCTGTTTGGTCTCAAGGTCTAG +GTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTAGGTCTTGGT +CTAGGTCTAGGTCTAGGTCTAGGTCTTGGTCTAGGTCTAGTTCTAGGTCT +AGGTCTAGGTTTAGATCTAGGTCTAAGTCTAGACACAAATTTCTAGGCCA +CGAAAATTTCTGCCGTGGCCTAGGATTTTTTAGGCCATATTCTAGGCCAT +GATCCAAAAAAAACTTTCCCTGTCTCCTCTAACCCATTTTTTTTGCAGAC +AAGCTCCCGTAACACAACCCCGGAGACAGCAATCTCCCCGTCACCAGCAG +TGTCCACTTTTGAAGTGTCCCGCCCGTCTGCCATCATCTCTGCCACGTCA +TCAACAACCTCGCCAATCTCAATTCCAGCAACAATCATTCCATCAGTATC +GCCGTCAGCTCTCGAACTTTTCGCCATGGCCCAACAGCTTGGAGTTCAGC +TTCCGGTTCCATTTCCAACATTGCCAACACACTTTTTCCCGTTTCAAATG +GCTCCGTTCTACGGGAACCCGGCTTCTATTTTGAAGTCTGAGTGAAGCAT +TTCTAATTTTCTTTTCTTCTTTTCTACACCAATATCTTTTTTCCATTTAT +TCAACTTATTCTTCATCCCATGACACGAAAACCTCAATTCTTTCATATTA +CAAACGATGCTCCGTTTCTTACGCCCTGCCCCACACACGCCCCGTCGTCC +AAAAATCAATCAATAATCGATTTTTCATAATATTTAATTTGTTTTTTTTG +TGTTTCACTGCTGTTTTAATATTTGAAAAGTACGAGTTTCTTCAAAAACA +TTTTTTGAATAATATTTGCTTCACACTCCACGCGTTTCGTAATGTATCGC +TTGCCCTGAAATTTTGTTGGAAATTCCATTTTTTGTGCAATTTTTGTTAT +TTTTCAAGCGAGAATAAATATTTTCTAGTTCTAGAATTCAATGAAATACT +TTGCAAACGCGCCCCATTGCACTTGACCGAGGGGTGAAACAAGTTCAGTG +TTTTCAAGATATTTTTTTTTAAAAACTTGAATTTGGAACAATACAAAAAT +CTGTAAAATGCAACAGTTTTCCAAATCTTGTCCACGTGGAGTACACAATA +ATTTTTCATCTATACGGAAAGATTTCAAAATTGGAATGTTAAATTATTTT +GTGGTTTCTAGGCCATGGGAAAACTAGGCCATCAAAAAAATTCCAGAGTG +ACCTGGAAGTTCTAAAACTTTGTTGAAACTTGTCCACGCGGAGTACACTG +GTAGTTTATCAATAGAGCGCAAGTAATAATCCCTTGGAATTTTCCTTTCA +CCACCCCCTCTCCATTTTATATGAGAGTTTTTTCCCTCGCAATTTCCCAC +GCTCAAGAGGGTGGCCGCCATTTTTTTTTTGAGGGGGGTCGTATCTAGAT +TTGAAACACGTCATTTATGCTCAAAATGTGCCAATTTTTATTGTTTTTGA +GTTTCTAGGCCATTTTGGTAAGTTAGGCCGCATACTGACTTTGCGACTTC +CAAGGATATGGCCTAGCTTTTTTTTCTAGGCCATATAATTTTTTGAGTTG +CAACTGTGGCCAATGTTTTTTTTGGGTTTCTATGCCACTTGTGAAAAGTT +AGGTCATAGAATAACCTTACGGTAAACGGGTCCTCACAATCAGGAATTGT +GGCCTAGTTATTTTCCTAGACCACGTTTGATTTTTGTCTTTCTAAGCCAG +GTTTGGGTCTAGCTCTAGACCTAGGTCTAGTTATAGGTTTAGGTCTATGT +CTAGGTCTAGATCTAGTTCTCTCACGTGAGAAAATTAGGCCACCTTTCCC +CCTAAACTCTATGATCTCAAAACTAAAACTACTTTCTAGAAAACTCTTCG +AAAATCATAAAACCAATTTTTTATCACTATTTTCATGCTAAAATCCAATC +AGAAATTGATCAGAAACACGCATATAAATATTACGACTATAAATTCATTT +CTTTTTTTCATTTTTCCCTCCAGAAGGCTCTTGGCGAGAAAAATCTGCAT +ATTTTTTCTACTTATATGTGTCGAGACATGTGATATTCCGGCCGGCGGTG +GCTCTGAATGAATATTCAATTGAACGAGAAATATATATTCTCTCCAGAAG +GCGTTTATATTATGTGTTGCTCCTGTTTCTGCTGTATTCGGCGTGGATTT +GGTATGCTTCTCAGTGGAGTGCAGTTGCAGCATTTTTTTTCTTCAAATTT +TGCAATACTCTCGAACTTTTTGCACTTTCAAGCCTTTTTTTGGGTTGCCT +AGAACACTAGAATTTCTGGACTATTTTGAGATTTCTAGGCCATTCTTGAG +ATTTCTAGGTCATATTGTGATTTCTAGTGCATTTTTGGGTTTCAAGGCCG +AATTGGAAGTTTTAGGCCATTTTTCGGTCACATTTTTAGGCCACTTTGAG +GATCTTGTGCCAAACTGGGATTTCTAGGCCATCATGGGATTTTTAGGCCA +ATTTCGAGTTTTCCAATCATAATATAATTTCTAGGCTATCTTGAAATTCC +TAAGCCAGTTTGGAATAATTAGGCCATCTTGGGATTTCTACGCCATTCTC +GGATTTCTAGGTTAAACTGGAAATTTTAGAATTTTGGGGTTTTAGGTCAT +ACTGCGAATTTTAGTCCACGGTTGGATTTATAGGCTATCGTGGGATATCT +AGGCCGATTATGGAATCCTAGGCCAACTTAAAATTTCTAGGCCATTTCGG +GATTTCTAGGCCATCACGCCTCCTAAAAGGCACAGACAAAGTTCAAAACC +CACCAGAAAAAAGTGTGGTGAATTAGTCAGCAACACCCCATTTTTCTTTT +CCAAAAACTAAAAAAAAAGATACCCCTGACAGATATGGGCAGAGATGGGG +GTGCGAATCCTGAAATTTCCGAATTCCAGTGGGAGCTTTTTGTGCCAGAA +AAAGTAGTGGGGGCAAGTGAGAATGTGTGTCGCCTTCCACTTTTCAAACA +CCATTTTGTCCGTTTCGCCGGCCCGAAAATAGGCTTGAAAAGCTGTGGCC +TAGAATTTTTTCTCAAAATTTTTGACGTGGAAGAATTTTAAGATTTTCGA +GGCCAAGAGGTGGCCTAGAATTCAACATTTATTGGCAATTCTTATCTAGA +TCCCGAACCCCGACCAGTCAGTTTTTAATTTCCGGTGTCTGAATTTTTAA +TTAAAAATTATTTTTGGGAGGAGCTCCTGTTTTTTTTTCGTCAAAAAATG +AAGGTGGCCTAGCTTTCTCATTTTAAGGCCACGAATTCTAGTTAATTTTT +TGTTGGCTCATTTTTTGTTTCAAAAAACGAAAGTTAGTCAAAAACTTTTC +TGCATATCAAATGCTCTTTTTGAGGTTTTTTCCTGCAAAATTTTTCTAAG +AAAATTTGAATTCCCGCCAAAATTTTTCTCAGAAAATTTGAATCGCCGCC +AAAATTTTTCTCTGAAAATTTGAATCGCCGCCAAAATTTTTCTCAGAAAA +TTTGAATTCCTGCCAAAGTTTTCACAATGGGTCTCACCACGAATGGTGAC +AGACCCCGCCCACAATTCTCAGAGACATTGGGTGTGTTTTAGACCAAAAA +AATAGTTTTTTTGACAAAAACAATTTTCCAGCAAATACTTGATCAGTTGT +CATTTGTCTGTTGAAAGTGGAAAAAATAAAACATCTTTCCTTTTTTCTGC +TTCTCCCCCTCCTCGTCCTTTTTGTGCTCAAAACTCAAATGGCTCATCTC +AATTGCATGACAAATTAGCAAAAGATGAGAGCAATTTTTCCCTGTTTCTC +TTTTTTTTCCTCCGTTTGGCTCCTCCTCATGTCTTTTTTAGTAGTTTTCA +GAGTTTTACTATTGAATGTTCAAACTGGCTAAAAAATTTTGATTTTTTTT +TCTTTTTAAACTCTTACGAAAATTTTGATATAGGTTAGAAGCCTAAAATC +GACGGCCGACAGCGTTTACATTTGTGGCCTAGACTTCCAAGCCTTGGCCA +TGGCAAAAACTTGTTTAGCCTACCTTTTCAAATAGTGGCCTAAAAACCCT +ATACTATTTCTGAACTAACTGTTTACTCAAAAGAGAAAGTTAGTGGCCTA +ACTTTCTGAATGGTGGCCTAGAAAACTCAATTTTGGCACTTTCATGACCG +GTCATCAACCTGACATTGATGGCCTAAGTTTTAATGAGTGGCCTAGAAAA +CCAAAATATGGCCATGCGCTCAGCATGATCTAACTTTCCAACTCTGCTAT +AAATTCCTTGGGGGAAACCTCGGCCATCACGGGTGGCCTAGAAAACTGAA +ATTCGGCCAAGACCCCGTAATTCATGGCCTAACCTTTTAAAAGGACAGCG +TTTGGCTTTGGTGGCCTAGTTTTTTGTGGCCTAAGTTTACAGAAAAAATC +CTCAGCCACAACCTTTACCCTATACATGAAATCACATAAAAATGTCCAAA +TATTTTCCAATTAAATTTCCAATTCTCCACCCTTAATTCTTCATTTTCTT +TTCTTCTTTTATTCCTTTTTCACTCTCTCATTCTGAAACTAATCTTTTCA +ATTCTCAGCTTCTCTTTTCTGGTGTGGCTCATTTTCACTTTGCTCCCGCC +ATTTTCAATAGGATTATCCGTGCACACACACACATGGCTCAGTGAGCAAC +ACCAACAAAAAAGAGCATATATAGATATACAACGATATCTAACTAGTTAC +ACAGGAGCTTCTGTTGTTCTTCTGTGCCCCTCCGAGCCGAGACAAACTTT +TGGAAAAGAGCAACGCTTCTGGAGCCGACATATTCGAGAAATCCCGGAGA +CAATTGAGACCACTATGAGGAAATGATGGTCGAGGAGGAAATGAGAGATG +GCGTTGCTCAAAGTGCGCGACGAATGCACCAAGTTGGTCGGTTATCAGTG +AGTTTTTGTTTTTTGTTGGCCGAAGTAGAGATAACTAGGCCACCTAGGTA +GGCTGACGATCTTCAGTTTGCAAATCCTCTTCCACCGCACTTTTTTGAGC +GATCTAGGTTTGCAAAAGGTAGGCCGCCTGGTCCACCGTACCTGTCATGA +TGGCAGAGGTCTGGGAAAGCTAGGCCACCTGTCTGAGCTGATGGTCTAAG +GTCTAAAGTTTACCAAAAACTCTTCCACCGAAACTTCTAGGGCGACCAAG +GCTTGCAGAAGCTAGGCCACCAGACTTGGCTGGTGGCCTAGAATTTTCAA +GAACTCTTCCATCGTAAATTATTAGAAAGCCGCGATAGGAAAAAGCTAGG +CCATCAAATTACCTTAGTGGCCCAGAATCTATAAAAACTCTCCCATCGTA +CTTGCAAGGACGGCTGAGCTTGGAGGAAGCTAGGCCACCAGAATAGGCCA +GTGGCCTAGAATCAACAAAAACTCTTCCACCGTACCTCCTACAATGGCCG +AGGTAGGGAAAGATGGGCGCCAGGCTAATCTAACTTTCCTAGACTGACCT +AAATGGGAGAAAACTAGGCCACCGGGTTTACGGAGTGGCCGAAAATTTAC +AGAGACATTGCCCTGACTATCTGACTGTTTTTTTAGCGAAAGAACTTTCA +TATTTTCTAGGCCAGGGGCCCCCTACGCCCCAACACAATCCAATTTTTTT +TTGCAGATTTCTAAACTCGCACATTTGTCTCTGCATATCACTCATCCAAC +TTCTCGTCTGCTGCTGGGCCGTTGCTCAGCACGTCAACTCCTACATGACG +CACAGTAAGGTGAGCCAGAGTTCATTGGAGCGAATTTGTAACCAGAGAAA +ATTCAAAACTTAAAATTCAGATCTTAAAATGTGATTTTCTGGAGGGGAGC +CTCCCGCTGGAGGCCGTGGACGCTGTAATTTTCGATATCCGACTTTTCCA +TTACCTATGGGGCATTCGAGGATGTGTGGCAGAGTATTTGGATGGTGGTG +GGTACTTTTAAGTTTCCCACGAATCTTTACATTTTTCAGGCTTCGGGCGA +CTTTTGTGGTGCGTTTCCCACTGCTTAACCCTGGTTTTCTCCATTCCGGT +CACCTTCATCTCCCATCCGAAACCCTGTCTCTTTTGGCCGCTGCTTTTTC +AGGTGAGTTGGCTGAAAAAATTTGGAAAAAAACTTTTTTTAAATTTTTTC +CGAAAGGCGCAGTGGGATTTTCCACGACTACCACTCACAACAGCATGGTT +CGAGTCCGCGTGGGTGTGAATTTTTTTTCTAGTTTTTTTTTGAAGTACGG +AAATTGTATTTAGCCTTGAAAAATTCTAAAATAAGCAAACAAAAAAATCT +CCGATCAAAAACCAAGTAATCCGTCTCCAAAAAGCGCAGCAACGTCAAAT +GGTCCCACGGGGGGCCTGAAACGACAAATTTCCTGACATTTGACGGGTTA +TCCATCCGCCACCCTCTCTTTTGAAGGAACATTGACTTTTTCCGTTGAAA +TGGATAAAAAAATTGAAAAGAATTAGATAGATTCGGGAGAATGAATATGG +TGGCCTAACGTGGTGCTTGACCCATGGCCTAGAAAACCAAAACTCGGTCA +TCACCCTGATTGAGTGCCCCTTAAGAGATTAGGCCACGTACGACGCAATC +CTAGGCCACCAATAGTTTTCTCGGCCACAGCCACCCCAAACAAAAATCTG +AACTTTCTGATCCTTTACATCTGTACCCACTGAACCGTTTGTTTATCTTT +TTACTCGCTCCACGGGAGCAGAACTTTTTTTTTGAAATTCCACAAAAGAA +TGGGACAGACACTAGTGTATTTTGTTTTTTATTCAGACATGAGCCAGACC +AGAAATAGGATTGAATCTCGGATTTCAGAGCCTGGAAAAAATCGGAAAAA +ATCGGAAAACTGTGGGAGAACTGAGTTGGGTGGTAAATTTGGCAAATTGC +CAAAATTTGGGGAAATTAACTTTTTCGGTAATCTGTAACTACAGTTTTCC +TAAAAATGTATGAACCTTTTAGTGATTCTGCATAGTTTTTCAGGTCTTTA +AAATTGAACCTACAGTACCCCGTACAGTTCAGAAGATTGCAAAATTCCAA +GTTGACCACTTTTAAAGCGTGTATCTCGGCTGATTGGGAAAGTATCGGAA +TATTTTAAAATACAAATTTATTGTTGGAAAATTTTTTTTTTACTTAAAAT +TAATTAAAATTCAGCTTTCAAAAATGAGCAATGTATTTATAGATCCCATG +CAACTTTGAAATTTTGTATATCCGTTCAGTGTAATGCTATCAAAAAATTT +TCAACTACAAAATTATAGTAAAATTTAAAACAAAGAAATTGTTAGTTGAC +AACTTTTTAATGAAATAAAGTACAACCGAGATATGAGTTCTCAAAGTTGA +GCTACTTTATCGGCAACCACAATATAAGTCGCCCCCGTACAATGCACCAT +GTGGTAGAAAATTTCGGTTTGATCTACTTAGATCTACAAAAAATGCGGGA +GAAGAGACGCAGAGTTTTCTTTGCATAGCTAAGAACGTGCTGACGTCACA +TTTTGTTGGGCAAAAAATTCCCGCACTTTTTTGTAGATCAAACCGTCGTG +GGACAAACTGGTACCTCTTCGTTTTGTTGGTATGAAAATTTTGAAACTCA +CTTCGTTTTGTTGGTATGAAAATTTTAAACTAGAAAAGCCAAAGTTGAGC +TAGGCGCTCAAATTTGGTAGCATTTACTTTTTTCAACAAAAAAATAGCTG +GCCGAGCTTTCCATTTTTACGGCCACGTTGCAATAAAAATCCAGGAGGTC +CATGTCATCAACAAAAGTGCAAGGATGTAAAACAATTACACCGAAACGTT +TGTCGGGAACTGCTTTTTCAAAAAAAAAAGGATCTCTCCGAACACATGTC +ACCCCCAGGGTTCTAGCGTCTCCCTGACCTCGCGAGCTATTTCCTTGAGA +CATATCTCTCCGAAACCTTTTGTAATGGTTGTTTCATGTTCTTCTTCATC +TTCTTCTTATTCTTCTTGCTGGGATAAGCAGTTGAAGAAAACGAAAAGAA +CACATAAAACACAGGCACACACACACACACATACACACCGTAATATCATA +TAAAAGTGCGTCTGCGTCTCCCAGAGCGCCCTGGGGGTAAGGAACGCGGG +CGCCCGCAAGGAAAAAGTGCAAAGAAATTAGAGAAAAAAGACCGGTCTCT +CACTCACTTCTCGATCCCTTTTCTTCTCTAACTATAAAAAATGTGTGGCC +TAACGAACGAAAGCGAAAAAAATCATCGAGAGAAGTAGTGAGAGAGAGAG +AGAAGAAAGAGTTTTTTTGGACGCCGCCGCAGCTGCCAAGCATCAATAAT +GACATGCTGGAGAAAAAAATTCCAAAGTTTAAATGTATTGGGGATCAGAA +GCCTAGACCATAAGCCCCTTGTAGAGTTTTCTCGGCCATAGCCTTTTTGG +TACGGTACATATACATAGAGACTTCAGATTGGGAATTGCGAATCTGTTAG +AGTAAGAATAGGCCTAAAACATTATTGGGCCTAACGGTGACGGAGACTAG +GCCTTGTTGGGAGCTTAAACTATGACATTGCCTAGAACGTTGTTCTATCT +TGGTTATGTGGTGTCGGGCTTTCATGATCAGCTCCTCTACTTTTGTCCAG +AGAAGTTTTGGACTTTTTCTATGGGTGCTTTGGGCTCTATTGCACAAATA +GGTGATCTTGCGCACAACACAACGTAGATCAAATTCTTGTCTAGGCTCTG +CAGGCTCCTGAGAGGTGTTTTGTACAAGCCCAAAGCAAAAGGATCTCAAA +ATGTTTACAGGACTTCAAGCAGAGGATTTTTCGATGATTGCCAAAAATTT +TGGAACTTTTATAGGCTTAAGCTTATGGTTATGTTTAGGCGTAGGCTTAG +GCTTAGGCGTAGGTTTAGGCTTTGGCTTAGGCCTATGCTAGGCCTAGTAC +CATAATACTATTCTTACCGCCGCGCCTGATCAAACCAAAGAGTAGGTCAA +CAACCAATATTGACTTGCACTTTTTGCACGGTTAACTATATTACGCATAT +GGCCAATTTTGTTAGGGAGCATTGATTCATGGAAAAAATTTCGGAATTTA +TGAATGTTCAATTAAACTGGACTACGACAATTATTGGGTTCAAACATTTG +AAAATTTTTTGGCCGACGTCGGAACGTCTCACTTTTTCCTGATTTTTGTA +GTTTTTCCTTTTTACCGAATTTTTAGGAATATCTGGGAATTTCTCGTTTT +CTGATTTTTTTTCAATTGTTTTTAGATCCCCCAAGCCTAAGCCTAAGCCT +AAGTTTGAGCATAAGCATAAGCCTAAGCCTATGCCTAAGCCTACGCCTCA +GCCTAAGCCAAATGCGGAGCCTAAGCCTAAGCCTAAGTCTAAGTCTAAGT +CTAAGTCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTGCCGGAGCCTAA +GTATAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTATGCCTAAGC +CTAAGCCGATGCCTAAGCCTAAGCAAGTTCCGACATTTTCGACAATTATC +TAAAAATCCTCTGCTTGAAGTCCTGAAAATCTTTAGGGATCCTCAAGTTT +CGAGTTTGTACGGAACGGCCCAAACGCCTCTTGGGAGCCTGCAGAGCCTA +GACAAGAATTTGATCTATGTTGTGTTGTGTACAAGGTCACCGGTTTGTTG +TGCATCAGAGCCCAGAGCACCCACAGAAAAAAGTCCAAGAGTGTATAGCC +TACGGTAGTCCTTGTTTAGGAGACATAGACAGTCTCTTTCTCTAACGGTT +TTTGTTTATTCTTTTTTTTTCTCCCCCTACTTTCCGACAGACATTTTCAT +CTTCATCTCCTTCTGCTGCGCGAATTGAATGGTCTATAAGTGTCTGCGTC +TCGCCGATTCGTACAGTCTATCGCTTTGAAATCGTCACCCCCAGGCAAAC +AGGACACCCGAACACACACACAACTATCCTCATTCTCAAAAAAATGGCTT +CACTGCATAAAAGTGCAGAAATTAGAGAGTATGCGGAGATTCGGAGAATC +CAGAGAGAACACACAAACACACTCGGAAACTCATATAGTTAGACCAGAAT +GATGGCTTTTTTGGAAATTTGAATTGGAAAGGGGTTTTTGAAAATTGGTT +GGAAGCATTTCAGATAGATTTACATTGAAAAAAATTAGCAGGAGCACCTT +TTCCATTTTAAAAAAATTTGTTGGCTTTAACTTTTTTCACGGATTTCCGG +CTTCCCTCATAAATTGAAATGGAAGAGTTTTTGCCGAACTAGGCCATTTT +GGCTCAGCCATATCTGGGGTAGATTTACGGCGCGTTGCGTGTCGCGTCGC +GGCTCGTTTTTAGTTGTAAAACTAAATTTATTTGTCCGTGTGGAGTACAC +AACTTTCCCACGCGTTGTCCATCTGAAGATTGTCAATGGAGCGCGAAAAA +TTCAGTGAGGAAGGCAAGAACTCCGTTTTTTTTCAATACTGAAAAGTCTA +ATATTGAATTAATAAATTATTCAAACATTTAAAAACAATCATTTTTAGTG +TTTTGAATTTTTTTTTAATTTCAAATTTTTCTTTAAAACATTAAAATTTT +AAAAACATTTCCAAATTGTTCCAAATAACATTATTGAACTCGTAAAACAA +ATTTAAAGGTGAATTTTCATTTATTTCGTTAAAAAATTACCTTTTAAAAT +TTATTTTTTCAAAAAAATCTGGATTTTTTTTCTGCGATAATATTCGAGCA +GTTTTTTTCGATTTTTTTTCTGAAATTCTGTGAAATTATTAACATTATTT +GAATTAATTATTCAAACAATTTCAAACAGAAATACAACGAGTTTTTCCAT +TTTTTATCATTTTCCAAAGTTTCAGAAAAAAATTTCGCAAAAAAAATTTA +GATTTTTCCAAAAAAATTAAATTTTTGAAAAATTCTCAAACGCACGGATT +TCTGGCTTCCTTCATAAATTGAAATGGAAGAGTTTGCCGAACTAGGCCAC +TTTGGCTCTGCCATATCTGGGGTAGATTTACGGTGCGTTGCGTGTCGCGT +CGCGGCTCGATTTTAGTTGTAAAACTGAATGTATTTGTCCGTGTGGAGTA +TACGACTTCCCCTCCGACAGGCGATTATCAATGAAGCGCGAAAAATTCAG +TGAAGAAGGCCAGAACCCAAAGTTTCACCGAAAAATTCGAAATAAAAAAT +CCTGAAAAATTTTTTAATTTTTCCATAAAAATTAAAAATTTTTAAAAAAT +TCCCAAATTGTTCCCAAGACACATTTCAGAGCAGGTTTCAAAAAATCATA +TAAATTATTTATAAGGGTAACAACACAAAATTTGGGTAACAAGAGCAACA +ATTTTTAATTAAATGTTTCATTTTTCATCAAAATTACTCAATTTTCCTGT +TTCAGCAATCGGCCTATGGTATTTGCCTCCTGGTTCTTCTTCTAGCAGCT +CTTCCAAGAATTGTTGTAGTACTTGCGTCTCCACAAGCGGCTCCGTTGAT +TCCTATTCTGTTTTATCTTGTTGGCACCGCGCTCAATTTTTTTCATGTGA +GTACTTGCTCACTTTTTTATGGTCTAAAAATTGGCGGGAAATTCAAAAAG +TTAAGAGTTTCAAAAAGATCGGCATAAAATTTAAATTGAACATTTTTGGG +GATTTTTTTGGAAAAAAAAACAAATTCGAAATTCGACCCATTTTGGCGGG +AATTCAAATTCTTTTAAAAATTTCGAAAAACATTTTTCTGCAAAAAAAAA +TTTTCATTTAAAAAAAAAACATTTTAAAAAGCAAGCTTTGCCGGGAAGAA +TTCAAAAAATGTGGCTGGGATTTTGGCGCGAAATTCAAATTATTTTAAAA +AATTTTTGAGAATTTCTTGAAAAAAAAACTGAAAATAATTTTGCGGAAAT +TTGAATTCTTTAAAAAATGCCAAAAAAAAAAGATGTTTGTGCAGAAAAAA +TTTTAATTTTTAAAAAGCAATTTTTCACGGATTTCTGGCTTCCCTCATAA +ATTGAAATGGAAGAGTCTGCCGAACTAGGCCATTTTGGCTCTGCCATATC +TGGGGTAGATTTACGGCGCGTTGCGTGTCGCGTCGCGGCTAGATTTCAGT +TGTAAAACTAAATATATTTGTCCGTGTGGAGTACACGACTTTCCCTCCGA +CAGGCGATTATCAATGAAGCGCGAAAAATGCGAAGAGGAATCTGTTCTAA +AATTAGGCGGGAAATTCAAAAAGTTCAGGGTTTCAAAAAGATCGGCGAGT +TTCAAAAATGTCAAAAATATTTTTCTGCAGAAAAATTGTCGACTTTTTAA +TAAACTTTGCCGGAAAGAACACGTGGTGTCAGAGTGTCCGGTTTGATCTA +CGTAGATCTACAAAAAATGCGGGAGTTGAGAAGCAGAGTTTTCAACTGAT +TTCGAATGGTTAAGAACGTGCTGACGTCACATTTTTTGGGCGAAAAATTC +CCGCATTTTTCGTAGATCAAACTGTAATAGGACAGCCTGACACCAAGTGG +AAGAATTCAAAAAATGTCGCTGGAATTTTGGCGCCAAATTCAAATTACCA +AACGGTATTTAATACATAGAGCTTCTCACTCAACATCTGAGCTACCGGAA +ATTAACAACCTTCACATTTTTTGGTCATTACTCACACACATGTGGTTTCT +AAGCAAGTTTCAGATACTTTTTTTTTTGTTTTTTTTTGAATTAATACTAT +TTTTTGCAAAAGTCGCTTCGGGACCCAAAAAAAAAATTCAAATTCTTTTC +AGTTATACGTGTACTGGCACTGGTATTGGCACGTGAGTGCCATGTGGAAT +TCGGTGGTCCGTGTAAAGTTCGGACAGCGGCTCGAAAACGCGAATAAGCG +AAGTCGACGGGATAAGCCGATTGTGCCGAAGGAGGAGATCGATGATGCCG +TTTTGCATTACGTGCCAGCGAATAAGCCAACTGAACAGCAGAATCATGTT +CAGCACAATCATATCAGTCAAAACGGGATTCAGCAACCAAAGGTAGGTCT +ACCTACCTGCCTATTTTCCTGCCTACTCGCCTAAGTTTGTCTAAAATCCA +ACTGCTTGTCTGTTCTGCATACCAATATGCCTAGACATACCCACATTTCT +GCTCATCTTCTAACATGCCTGCTCGCCTAACTTAATGCTGTATGCCTATG +TACTAGGTTACTGCCAGCCTGCCTACTTGCCTACCTACACAAATGCCTAT +CTGACTACATCTATATCTATGCTTCTCTATGCATAAATGCCTGCCAAAAT +GGCTAACTGCGTGTCAAAGTTCATGCATGCCTGCCTACCTGCCTACGTGC +GTACATGCCTATTTGCTTACCTAAATGATTACCTGCTTACCTACCTGTCT +ACCTGCTTAAGAGCCCTACTTATTTGCCTACCCACCTGACTGCGTGTCTC +CTCTCTTTCTGCCAATCTAGGCCTACATGTCTATCTAGGCCTATATAAAT +TCCTACCTGCCTACCTGCCTAAATACCTACTTGCCTGGCTATGTCTTCTT +ACCAACCGTTTTTTTATGCCTACGTACCTGCGCGCATGCCTACCTACGTG +CCTACCAACACCTACAAATACCTGTCCGCCTTCATCACATTTTTCACTTT +CAGGTAATCCTTCCACCACCGAACCCCTACAACACCGCGCCCACACATTA +TCGACGCCGATCCTCCACAGAAGCCCACCGCTACCACCCACCTCGGCAAC +CGAGAAGCTCGGCGCCAACCCACCACCGAGTACCGGCCGACTATCCGAGT +GACGAGGAAGACGACTATGATGATACGGAAGGAGACGACGCGGATATTGA +TGATCTACCCACACCGCCACCGCCGATTTACGCCGTCCGCCTGACCTCCG +ATTCGTGGGAGAATCAGATGAGCCGCCCGTCGGGTAGACGGCGGTTACCG +GCGACTCCGAATTTGCCGAAACATGGAGAATTGCCGCAGATATTTAATAT +TCCTCATGCTAATGTTTAATCAAATTTTTGGGGTTTTATGGGTTTTGGAT +TTTCGGAGCGGAGCTTCATTTATCGCTTTAATATTGAATCAGGGGTGGTT +TTCAATTCTGGCAATTTGCCGGTTTGCCGATTTGCCGGAAAATTTAATTT +TCGGCAAATTGCCGATTTGCTGTTTGCGGGATATCAGATTTTCCGAAAAT +GTTTAGAGGGATTTTTTATAAGACGAAAACACTAAAAACTGTGTCTTTTT +GAATTTTTTCCACTTTTTCTACATATTTTCATAGAATTTGCTTACTTTTC +AAATTGCCGATTTGCCGGAAATTTTTAATTCCGCCAATTTGCCGATTTGC +CGTAAAAAATCGTTTGCCGCCCACCCCTGTATTGAATTATCCGGAACACA +GCAACACTCTGAAATTCGAGCATTAGTTAAATGTGATATTTGAAAAGTTT +TGCAAACAAAATAATTTTCCCCAGCTTTCATCATTTTTTCTTTCAACAAA +AAAAAACCGAGTGATATTATGATTTCCAATTTGTGCTATTTTGAGTTTTA +TTTTATTTTATTTTGTTGTTTTCAATAAATAAACGAATATTTTTTGGTCA +TTTTTTGGCGCTATGAAACTAAAAAATTTCAGGTAACTTAGCGGGAAGTT +CGTTTTTTTTTCATTTTGGCAGGAAATTTCATTTTATAAAATGGCAAAAA +CTTTTCGTTAAAAGTTTTTAAATTTTGAGAAAATTGACGAGAAATTAAAA +ATTTCAAATTTTTTGGCTCTAAATTAGGATTATAATTTTCCGAAAAAAAA +TTTCCGAATTAAAATTTGGCGTCTCAGTGTGTTATTCAATTAGAAAAACC +TTCAAAATATTAAGACATTTCGGAGGCACGTGGTGTCAGAGTGTCTATGC +TCCTTTAAATGATGCATTCAAAGGCGCTTACACACCTGCACGTAATCTCT +TTTTTGTCTCAAAACAAAAGGAGCTTCAGACTCTCATATCTCTGCAACTC +TGTGTGAATAACAATTGGAGCCCCAGAGCTCCCGGCTCCACACTGCCCGT +TTCCATGGAGACACTCCGATTATTATGGGAGCCACCACTGCTCGCCGAGC +AGCAGCAGCAGCAGCCCATTGTTAACCCGATGACCAATATCTATATTTGG +GTCCGGACCGCCCGTTCCCTTCAGTTTTTTTATCCGACTATCGATGTGGA +GGCCGATGGGTTCGGTTGCTTCTATGAGATTTGTTTGGAAATTGTTGGCT +TGTTGGAGGAGTGCGATAGGATAAGGTAAGCGTGCTCTATTGATAACACG +AATTTTTGTGATTTTCGGCAACATGGGATCGTGGTTGCCCAAAGGGAAGG +AAACGCGCCCCATTGATAAAATCATTTCGCAATAGAGCGCATTTTCATCA +TTTTTTTGCAGTTTTGACGAATTCGAGACCCTCTGCGAGAATAGAATATC +GGAAGTTTATGTGGAAGCAATTTTTCAAAATGCTGTGGAACAAGGAAATG +TGAGTTTTTTTGTGATTCTGATGCTAATTTAGCAAGTGCGCTCTATCGAC +AATTATGACTTTGTGCACGTTCAAGTATTTTCTCAAAGTTTAACACAGGG +TTCTGGCCTTCCTCATTGAATTTTTCGCGCTCCGTTGACAACGGACAACG +CGTGGGAAAGTCGTGTACTCCACACGGACAAATCACATTTAGTTTTACAA +CTAAAATCGAGCCGCGACGCGACACGCAAGGCACCGTAAATCTACCCCAG +ATATGGCCTGGCCTAGTTCGGCAAAAACTCTTCCATTTCAATTTATGAGG +GAAGCCAGAAATCCGTGAAGTTTAACAAATTGTGAGGTGTAGCAAACACG +CTCAAGTGACAATTTTTACTTTATGCGTCATAAATTTTTTTCTGAAACTT +AGAAAACGCGCTCTATTGCTACTTTGAACGGAAAACGCGCTCTAATGTCA +ATTTTATTTCCAGATAAACGCCCGCCTAAAGCTTCTCACCTTCTCACTTC +TCTTCGCAGGTCTCCAACAAAAAACTAAAGATCTCACAAATTCCATCAGG +TCGGACGTGGTCTTGACACGAATTTCAAAGTATTTTGGTAAATTTGAAGA +ATAATATTTGTTATTTTTTTGTTTTCCGAACTTTACAGGCCAAATATTCA +AACTTTTGTTCCAATTAGACGTGGGCCGCCGGTTACAGGACAGAGAAATT +GTGCACGCCATTGGAAATGGGCAGGTGAGAAGTTCGGCTACAAAAACGTG +ACGCGTGGCCTAGAAAGATTTGTTTTTCCACAGCTTTTTCCACAGCTTCC +ACAGCTAACGGGATGGCCTAAAAAACTCCACGGTCGTTTAGCGATAGAGC +GCACTTGCACATTTTGGGAATCTTCTGGAAGAAAGTAAACGTCACAAAAG +GCCTAGAAATCTTTATCGTGTGTGGTTTAAGAAACAATTCTCGGCTTTGA +AATTATGGTTGCTCGGGGAAAAATGATTGTTAGAAGCCGCACGCTTGCAC +GCTTGCACAGCTTGGGAATTTTCTGGAAAAGAAGTGACGTCACTGGTGGC +CTGTAAATTTTCGCCATGTGTGAATTAACAAAACAATTATGGGCTTTGAA +ATTATCGATTTTCACGGATTTTTGGCTTCCCTCATAAATTGAAATGGAAG +AGTTTTTGCCGAACTGGGCCATTTTGGCTCGGCCATATCTGGGGTAGATT +TACGGCGCGTTGCGTGTCGCGTCGCGGCTCGATTTTAGTTGTAAAACTAA +ATTTATTTGTCCGTGTGGAGTACACAACTTTCCCACGCGTTGTCCGGCGG +GCGATTGTCAATGGAGCGCAGAAAATGCAATGAGGAAGGCCAGACCACGT +GAAAATCAATAAGTTTTTCAGCAAAAAATGAAAAATGAGGAAATTTCGTT +AATTTTAGTTTTGTTAGCAGTAGTGCGCGCTCACATAGTTCAAGAATTTT +TTTTTGAAGAAAAGTGACGTCACAGATGGCCTAGGAATCTCATCTATGAC +GTCACTTCTCTTCCACTTTATCCTATTTTCAGGGCTATGAATTCCTGGAC +ACCCTATTTGAGGGAACAGTAAAGCACAGACATGGAAACTCGAACCATCA +CGGCGTGCGCCCCCTTTCCCATATAATCCCCCAAATTCTCGAAAAAGCGA +GCAGTATATCCCTACCATTTTTGTGCAATGAAATCCGCCGACACCTTATC +AAAGACCCGTATCATATTGATGAGTTCTCAACTGACAAACCTGCTCAAAT +ATTTTCGACGGCTCGCCGAACGACACTGGCACATAATAGTCGACGGGTGG +TACACTTGCATTATATCAATCGAATTGAAGTGCTGCGGAAGGATGAATTT +GCGAATGTTCACCTGAGAATTTGTAATGATAAGATTAAGGCGTCGTTCGT +TTTTGTTCCGTTGAGGTGAGATTTTTTGGCCGAACTTTTTTTTGTTGCTT +TTTTTGAAAAATTTTTAAGAGATTTCATTTTTTTTTACAATAATAGAAAA +ATCAGAAAAAATATTCACGAAACCAATAAGTGGGCGGAGCATCAAACTGG +CACGCTCATTTTCCGTAGATCGTTTCTGCCAAAATCGAAAATTTCTTGAG +CTTTCTTGAAAAATAACGCTAAATTTAATTGTGAATTTATTATTATCTCG +AAAAAAATTATCAAACAGTCGAAAAGGGGCGGGCTTACATTTTTTAGCCC +CGCCCACTTTTAGATTTGTTTTGTTGAAAAATGTCCAAAACTGAGTTTTT +CTCGGAAAATTTGAATTCCCGCCAAATTTTTTTCCAGAAAATTTGAATTC +CCGCCAAATTTTTTCCAGAAAATTTGAATTCCCTCCAAATGTTTTTATTT +TCAGAAAATTTGAATTTCCCGTCAAAATTTTTTTCCCAGAAAATTTGAAT +TTCCCGCCAAAATTTTCCCAGAAAATTTGAATTCCCGCCAAAATGTTTTC +CAGAAAATTTGAATTCCCGCCAAAAAAAATTTTCTCAGAAAATTTGAGTT +TCCCGCCAAAAAATTTTTTTTAAAAGAAAATTTAAATTCCCGCCAAAATG +TTTTCCAGAAAATTTGAATTCCCGCCAAAATTTTTTCCAGAAAATTTGAG +TTCCCGCCAAAAATTGTTTTACTGAGAAAATTTGAATCCCCCCCCCCCCC +CCCCCCCCAAAAAATTGTTTTACTCAGAAAATTTGAATTCCCGCCAAAAA +TGTTTTTTCTAAGAAAATTTTAATTCCCGCCAAATTTTTTTTTAGAGAAA +ATTTGAATTCCAGCCAAAATGTTTTCCAGAGAATTTGAATTTCCCTCCAA +ATTTTTTTTTCTCAGAAAATTTGAATTCCCGAATTTTATTTTTGAAAATT +TGTGTGAAATTAAATTTTTGGGAATATTCATTGTGGCCTAAGTTGCTCCA +AATGGAAGAGTTTTTTAAAAATTAATTTCTCGTCCACGCGTCAATTGTAT +GCAAGAAATTCGAATATTTTCCAGATGTGAAACCGTATTCCTCGACAGAC +TTATGTACACAAAATGGATAGTTCTTGGCGCAGTACGCGGCATTGTAATT +GTTAAAAATTGTCAATCGACCCGAATTTCGGTGAGCTGCGACCAGCTGAT +TGTGCTCGATTCGAAAAATATCGAAATCTACGCCATGTCGCCGAAGAAAC +CAATAATTTTCAACAGCTCTGCGGTAACTTTTGCCCCATTTAACACGATT +TACGAGGTGAGTTCGGTGGGGCGCGTTTGCATTTATGAATTCGAAAATTT +>CHROMOSOME_II +CCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCC +TAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTA +AGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAG +CCTAAGCCTAAGCCTAAGCCTAAAATAGTGACTCTGGCAGTTCTCTAAAA +TAAGTGACTCTGGCAGTTCACCAAAAATTGTGACTCTGACCGTTCACCAA +AAATAGTGACTCTGACCGTTCACCAAAAATAGTGACTCTGACCGTTCACA +AAAAATAGTGACTCTGACCGTTCACCAAATATAGTGACTCTGACCGTTCA +CCAAAAATTGTGACAATGACCGTTCACCAAAAATTGTGACTCTGACCGTC +ACTATTTTTATTGAACTGCCAGAGTCACTATTTTTAGTGAACTTCCAGAG +TCACAATTTTTAGTGAACTGCCAGAGTCACTATTTTTAGTGAACTGCCAG +AGTCACTTATTTTGGTGCACTGGGGTGGGTCACGCCCCCAGTTCTCAGTT +ATGGGTACTCTGATCCACTCGGGACCCACTTTATCGTGTTCCCCGTGCCT +CATTTACCCTAGAGCTTCCTCCTTTACCTCTCCTCTCGCTATCTCTAACA +TTCCAATGGAAACTCCTATTTGAATTACCGCCACCGATGTGCCCGACGCG +ACTTACTGTTAGCCCTTGTTTTGCACAAATCTGTTGGCTTCCATATTTAA +AAGTTAATTAATGACCCAATGTTCTTTTTTTCTCTAAATCTCCACAAGAT +GTTCTGTTTTCCCTACTGGACACTATCGTTCACTGCGTCTCACCAATTCA +CATTGTCTCTACTTTACCTTTTTTGTCATAGTACACGTTCGCCAACGGTG +TCGACGGCCAAATGCTTTGGGCAGCGTTTGCTTTTTTTATAATTAGTTTT +ATTTTATTAAAACAATAGCTCTAAAGTTTACAAGTCATTTGTTATAGGCT +AAATGAGTTATGTCTAATAAGTAATTTGAACTAGATACTTCCGTGTAAGT +GACAATGTATCGGAAAAGTCCTCAAAGTGCGATGTAGAAGTTCACATGTA +CTTTGTTTGGCATGTTAGTAAAAGAGCCAGTATGCTGATTCATTTTATAT +TCTATATACTCATGTAATATGCCCATGTAAGGTTTAATTCCAAAAATATG +AGCGTGTTCTATTTTATAATATTTTACTAAAATACCTTTCAGTTAATTGC +ACTCAAATTTGTTGTTCTTCATTCTCTCGTTATGATTTAATCTTATTGCG +TCAAGGTCATTATTTTAGGTCCATTAGTTATCGATCTGAAACATGTTGTT +GTATTTTTCTATTCTTGTGAGCTCAGGACACCTCATACAACTCCAGAGAA +AATGTGTCTCATTATTCTTGTCTTTTTTCAAGATCTAATCAATTTTCTAC +ATTAACGACGTTTTTGTCGTTCTGCTTCTTTTTTTCGTTCGTTTGTCTCG +TCCATCAGCTGTCCACTCATTTCTCTCCCACTCACTAGGCAGTGCTTTGT +TTGGTTCCGATTGGCAGCTGGCTGCAGGGCCTGCATCTCTTCTATGTCTC +TCATTTACTTGCATTCTTTTCTTCGTTAATTTTTGTTATGATATTTAAAC +GGGAAGAAGAGTTTGTGGTTCTTCTTTTTATAATCACTAAAACTTTTGGA +TAAGTAACAATTTTCTGATAAAAATATTTTCACGGCGAAGAAAAAAGAAA +AAGAAGAGTAGTTTTTGCACGTTTTCATATAATTATTTTCGTTGATCAAA +TGTTCTTCTGGAGTTTTCTAATAAATTTCTTATCGACTTTTTTTCAGAAA +TTTTTCTCAACTTGTCATGTCAATGGTAAGAAATGTATCAAATCAGAGCG +AAAAATTGGAAGTAAGTTCTTTATAATTTCATTTATATACTATAAGTTTT +CTCGATCACAGGAGAAACAAAAACAACAGACAACACAAAAAACAATAAAA +CAATATTGCTCTAGTAATCAATAGTGTTGTAAAGAGGGAAGAAAATTGTT +ATCTGTGTAGCAGTCAACGTTGATTGAGATGTTGTGTTTGACTATAGAGT +TGAAAATAATAACTTCAAACTTGCAAGTCATGACTTATCAAACACTGCCG +GAACTTATTCTGGATCAAAGGAAAGTTGTCCAACTGTAGAGTCATGTTTT +TCAAAAGAAAACACAATTTTTAAGTATAAATATTTTGAAAAAGTATGTTT +TAGAAGTATGTCAAATTAAAAAAAAAATCCTTGGTTAAAAAATGATTTTT +TTGGATATATGTGTATTTTTAACTAAAAATATATACTTTACATATATATT +TTGGCGCAGTTATTTGATCTATAAATCAAACTTTTTGATAGACATTTTTT +TATATTTACAACAACTAGGGTTGTTATGAAAACGCCTATTATTCTACAAA +CTAAATTATTTTAATCATACATTCCCCACTATCTAAAAACTAATGCAATT +TTCAGATTTTGTCATGTAAATGGGTAGGATGTCTCAAATCAACAGAAGTG +TTCAAAACGGTTGAAAAGTTATTAGATCATGTTACGGCTGATCATATTCC +AGAAGTTATTGTAAACGATGACGGGTCGGAGGAAGTCGTTTGTCAGTGGG +ATTGCTGCGAAATGGGTGCCAGTCGTGGAAATCTTCAAAAAAAGGTATTT +TTAATTTAATGTGCATTTTATAATATAAATTCTTCAGAAAGAGTGGATGG +AGAATCACTTCAAAACACGTCATGTTCGCAAAGCAAAAATATTCAAATGC +TTAATTGAGGATTGCCCTGTGGTAAAGTCAAGTAGTCAGGAAATTGAAAC +CCATCTCAGAATAAGTCATCCAATAAATCCGAAAAAAGGTATTCACAATT +TGCATGATATTGTTATAATCTAATTTTCAGAGAGACTGAAAGAGTTTAAA +AGTTCTACCGACCACATCGAACCTACTCAAGCTAATAGAGTATGGACAAT +TGTGAACGGAGAGGTTCAATGGAAGACTCCACCGCGGTAAGTGTGTTTCT +TTAAAAATTACTTCCTTTTTTCAATTGTTTGAAATTAACAAGAAACCTGT +TGGAGCGTATTTCTGAACTTTTAAATCGAAAATATCATTTGCAAAAAAAC +TTGAAAATTGAGAAACTTTTTTAAAAGTGGAGTAGCGTCTGCGGGTTTTT +TTGCCCTAAATGACAGAATACATACCCAATATACCGAATATAACCGTAAT +AAAATTATGCGATTTTTATTTTTATTTTTCATGAATGTTAGGGGCAAAAA +ACCCACATGCGCTACTCCGCCTTAAGAAGAATCAGCTGTGAGCACTATCC +ACTATACATTGGAAATTTACAAATAAAATAGAGATTAAGTAATATAATTT +TTAAGGGTTAAAAAAAAGACTGTGATATACTATGATGATGGGCCGAGGTA +TGTATTTCCAACGGGATGTGCGAGATGCAACTATGATAGTGACGAATCAG +AACTGGAATCAGATGAGTTTTGGTCAGCCACAGAGATGTCAGATAATGAA +GAGTACGTTGTTTTGCAAATTGATTAAAAGTGGAGTAGCGTCAGTTAAAA +ACTCTAACATGTCTTAGGTTTTTCAAAAGTTTGGTCAAAGTTTTGGCAAA +CTGCCAACTTCTTGAAAACTTCGTTAAAAAAATTCTTGAAATGATTTGAA +AATTTGTATTATGTTATTCTCTTATTTCTGCACTATTCTATATGGCGCTA +CTATACTTTTAATTGATTTCTTGAAAGCAGTTCAATAATAATTAATTTTA +GAGTATATGTGAACTTCCGTGGAATGAACTGTATCTCAACAGGAAAGTCG +GCCAGTATGGTCCCGAGCAAACGAAGAAATTGGCCAAAAAGAGTGAAGAA +AAGGCTATCGACACAAAGAAACAATCAGAAAACTATTCGACCACCAGAGC +TGAATAAAAATAATATAGAGATAAAAGATATGAAGTAAGTCGAAATTGAC +AAACAGTGGTTTTTGTTTAAGTTTATTGCGAAATATTCAAAATTAGACAT +GTTAAAATTTTGCGAGATAATCTAAAGATTAGGTATACAGATTTTTTCAT +GTAAAGTTACATTCATCAAAATTTTTGTGTTCACCAAATTAGACAAAAAA +TGTTAGTTACACAGTATATTTATTTTTTATATCAATAAAACCTTTTTCAG +CTCAAATAACCTTGAAGAACGCAACAGAGAAGAATGCATTCAGCCTGTTT +CTGTTGAAAAGAACATCCTGCATTTTGAAAAATTCAAATCAAATCAAATT +TGCATTGTTCGGGAAAACAATAAATTTAGAGAAGGAACGAGAAGACGCAG +AAAGAATTCTGGTGAATCGGAAGACTTGAAAATTCATGAAAACTTTACTG +AAAAACGAAGACCCATTCGATCATGCAAACAAAATATAAGTTTCTATGAA +ATGGACGGGGATATAGAAGAATTTGAAGTGTTTTTCGATACTCCCACAAA +AAGCAAAAAAGTACTTCTGGATATCTACAGTGCGAAGAAAATGCCAAAAA +TTGAGGTTGAAGATTCATTAGTTAATAAGTTTCATTCAAAACGTCCATCA +AGAGCATGTCGAGTTCTTGGAAGTATGGAAGAAGTACCATTTGATGTGGA +AATAGGATATTGATTTTATAACGTGTAATTGAGTTTTGGCCAAAAAGGTA +TGGAAAGGTGGCTGTTTAGTTATATATTTTTCTATTATTTATTTGAAACA +TGCAAAATTGAAGTGAACAATAAGTGATGTTCATGGAAATTTAAACTGTT +TTATGATACTTTTTTGAGAAATTGAAAAATCTGTTCATTTTAGAAACAAT +GTCCACATGGTTCTAAGAGCTAAAATTTTTATTTTCATCCATTTAGAGTA +CTTTCTCTTTTAGAGTACGGCCCCAGAGCGATGTTAGAAACCTGAGATCG +GTCAACACAGACCGTTAATTTTGGGAAGTTGAGAAATTCGCTAGTTTCTG +>CHROMOSOME_III +CCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCC +TAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTA +AGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAAAGCGCGAAATCCTATGAA +ATTTCAAGGATTTATAACTTTTTGAGTCCGAAAAGAGTCGGAAATCAGAT +AAAAATAAAATCGGGCTTTTCGACCAAAATTAGGCCTCGAAAAGTCTGAG +AAAGCACGGAATCTATGGATTCACGGCTTTTTGATTCCGAAAAGGTTCGG +AAAGAGAAGAAAATCGATAAGAATCGATAAATTTGCAGAAGTATTGCAAA +TAAATTCCGATTTTCACTAGAATTGCGTCATTTGGGCGCAGAAAATCGGG +CTTTTCGACCAAAATTAGGCCTAGAAAAGCATGAAAGGGGTCCAAATTCT +GAGATTTCGCAACAGTTTTTGGACAAGGTTATCCCGGAAATTAGCGGGAA +GCACTGAAGATCGAAAAACTGAAGATCTTGTCGTTGAGAATCGTTCAACA +GCGTCAGTTACTACTGAAAAACTGATTTTTGAGCAGAAAATCTGCCGAAA +TGTCCGAAATCGGACGAAAATCAGTGGTTTTTTCGCCAGGAACTCGTAAA +CGAGCGGGAAAAAACACTAAAATAAAATACATAATCGACGACGGCGTCGA +AAAATGGACTTTGGAGGCGATTTTGAGATAAAAATCGCCTCTCTGAGACC +GCGTCACCGCAACTCGTGCCTCCATCTGACTCAGGATCCGAATCCGGCTA +ACGAGTATACTCGAGCCGGTTCGGTCGATGCACCAATGTTGACACCCATG +TTCTTCGGGGAGTCAGACCCGATAGGTAACAAACGTGCGGCTTACTTAAT +GACGCGCGGAGGATACGGAGCTAGTACGAGCGGTGCGACTGATGATGCAT +AGGGAATAACAGTACACAAGCTTGAATTAATCCAAGTTTATTATCGAATA +AAAGGATTAATCAAAGAAAAAAGGAGGAAAGGGCGAGCTGCATTGGGAGA +CGACCTTCCTCGACGAGAGTTGTTGAAGAATTGAATGGATCGTAGGCCAG +AGGCCTATAATAATTATTGTGTGGATTTACGGGCAACGACACTCCGGAGT +AACGCTAGTTAGCGAAGGAGCGCGGTTGCATCTGAATAGCGCATATTGGC +ACGTAATTCAAATTAGAAAAATTACTAAAATGATTTAATTAATATTTTTA +ATAGAACGAATGGAATATAATCAGCAAATGGTACAAGCGGACGTCACAAC +ACATTGCTTAATAATAAATTTCCAACTGAAACCAATAGATTCAGCCTTGA +CACAACTGATCAGAAACTTGTTATACATGTTAAAATACTCGAATTCATAT +TCATCGCCACCAGAATAATTGGGTTTGAACACTCTTGCAACTTCAACTGA +GATGGTACCGTAGATCCAGAAGATGCATTGTTGGAATGTACTTCTTCCCA +AAAGGTTCTGAGATTTAATTGATTTTTAACCTGGGCCTAAAAGTCTCACT +TACGTACATTTCTAATATTTAAGGCATTTAGTGCTGAGAAGTATTCGACA +GTGGCCTCGATGTTTTCAAAGTGGAATAAATAGTGAATTGGAATAATGTT +GAAATAATGACCAAAAACTTTACATTCTTTTGATTTTTTCCACTGATCCA +TCCGAGTAAGCTGCTCAAAGTCATCGATTGTTTCAAGGCACCACAATTCA +ATACTTTTCAACTCTTGAGAATCGAAATAGGGCAGCGTAGATATAATATC +ATTGGGTGACACAAAAATAATCGATAATTCCTTCACATGAATGCATTGCT +TAGATCTGAGGATGTTCAGAAAATATGTGGTAACGTTAAGGTCTTGTTGA +GTTTGTACAACAAATTCGAATTTCCTGACACGTCCCAGTAATATTCTCAA +ATCGTTGAAAGCTAGTTGCATGAAGTTATCTCTTCTGATTACTCTCTTTC +TTCTGTGAGCCACAATCGAATTCCCGGCATTGGTGTAAATGATTTTCATT +TTATCAATCCGCATTTCAACTCGACCATTGCATACCCAAAACGAGATAGA +ATCAAAATTAATTCCATTTTGAACAACGGCAGCTCTCAGACTTTTACAAA +TTTTGAGGTGAGTGAGTCTGAAGAATAATAGCTTGGTTATGATTTTTCAA +AGTTAGGGTACCGAAATCTTGGAAATATTTTTAATTGACTCCAAATTTTC +CCCTGATTCCGAAAATCGATGTGAAAAAAATCAAAAAAAAAATTCCTGAT +TTTATATTTAAGCTTGAAATCACGCATTTCATTTGCGCCCCGGTCTCTTT +TTCAAATTCGCGCCCTAATAAATTTGCATTGGAGCGCACTTGCATCGTGT +CATTTTCTTCGTTTTTTTCATTTATTTTAGCAGAATTCAATGTTTTAAAC +CAGTTTTATTCATTTGTGGAGAGTTTTTATCGGTTTTTTTTTGACTAAAA +TGAAAAAAGGGTCCAAATGAAAATCGAGATGAGCTAAGTCAAGCTTAAAT +ATAAACCAGGGAAATTTTTTGATTTTTTTTTTCACTTTGATATTCGGAAT +CATGGGAAAGTTGGGAGTCAATTAAAAATATTTCCCAGATTTTGGTACCC +CACCTTTAAATCAAAATAAAATCAACTAACTGATCCACTGGCTTTAGCTT +TTCCAATACTTGACCAAGGATCTCTGTGGGCATATCGGAAAGAGTAGGGG +AAATGTGATCCTGGCTGTAACAATCAAATTGCCATTAACCCAGTATTTCA +ACAAAAAAAAACTCACAAATTCATATATCGCACAAAATTAATTGCCCACC +ATTTGTCAAGTTCAGCTCCACGTTCTTCAGTCAGAGCACGTCGGGCTTCT +CGGCTGATTGTTACCATTTTCAAAAGATATAATTTCTTTAACACAGAAGT +TAAATAAAATATGTCCGATAGCAAAAAGTAGATGTGAATGAATTGAAGAA +GAACTGAGAAATAGCTAAATATCTATGTCTTAATTTTCATAGAGTTTCAT +TGTCAGATACTACAATGTTACTATTGAGAAAAATGTCAAACTGATAAGAA +TAGCAGCCAGCTTAAAATGAAAATTTGATAAGAAATTGCTGTCTTAATAT +TAATTATATTGTCGTCAACAAACAGAATTTTCACTTGCTAGTTGTTAGTT +TAAATTATATTTTGATACCGAAAAGTGTTTGAAAATGGGGGGAAACTAGA +AAATAAAGTTTTCTACATATTCCATATTTTCAGAATTGATTTCAAGATAT +GTCGGAAACAAGCCAAGAAGCTCGACGTGCACTGACGGAAGAACGGGGAA +AGGTGCTTGACAAATGGTGGGCAATTAATAATTTGAGATTCATGAAATTG +TGAGTTTTTTGGAAATACTGGCTTATTGGCAATTTGATCGTTACAGTCAG +GATCCCATCTCCCCCACGCTTTCCGATATGCCCTCAGAGATTCTTGTTCA +AGTTTTTGAAAAATTTGATTCTATAGAACATTAAGTTGCTTTGACTTTTA +CAACAAAAATATTCGGTATAAAAATGTTCTGACTTATTTGTCGAAAAGTT +TGTCGAAGTCTGAAGCCCGCCGTGGAAAAAATTGAAATTCATTTTGATTC +TATTTCGTTTGAAGTATTTAATAAAAATGTTATTATGAAATTGGATGGAT +TAAAAATTCTCTACAATGATGTCGCAAATGGTGCTTCTATAGTGGCTTAC +AATAACAAGGAAGCAATGATCAAAGGAGAAAACTTCCTGAAACTAGCTTT +CAATGATTTGGGAATACTACTGGAACGTGTGAGGAAATTCAAATTTAAAA +TCTATGGAGACGATGTACATGCCATTGCCACATTTCTTTTAAATGCTCTC +AAAGCTGATCAGTGTGTTCACGTAAAGAAAGTAGTGCTTTTTTACGTGCC +ACTCATTGATATTTGCTCAATTCTCTCGTATTTTGATTCTGAAATGTTGG +AAAGAATTGACTTGCGTTGTAATGATACAAACGCTCATTTTGAACAACTT +GCTCAAAAAAAATTCCAACGAACAAAATGTGTAGAACTTTACAAACTTTT +TAATAAAGATTTCCAAATTTTTATACAGATTCACTAAATTTCCAGAGTTT +TCCCACAAACCGACACACAGACCGACCTGGTAGTGGAGAGGACAACATCT +TTATTCAATCCAGTCAGTGAAGTGGAATTAAACTGGGCTTCAAGGAAGAA +ATGGCACAACGGAAAAGGTCGGGAGAAAAACCAAAAGTCGGAAAAATATT +TTTTATTGAGATATAATTTTTTTTGGTAGAAACATTTTTCTTCGAATTTA +AATTATATTTCGCGCCAAAAATAAGATTAAAAACCAAAAAAAAATCCGAG +TGTGGAGAAGTATTTTCGAAAATATTCCTCTAATAATACCCTTTAACAAG +GGCTATAATAATGGAATTTCGGGTGCTTGAAAATGAGTTTTTTGAGATTA +GAAGTATGAATTTTTGTGTCTGGTGTTAAGTTATTTAAGTTATATTGAAT +GGAAATTTTAAAAAAATTCTGAAAAAATATTTATAATTGTTATTTGAAGC +TACTATTTCACCTGGAAACTTCTAGAATTTCCAATTTTTTTAAAAATTTT +TTAAAAATTTTTTTATTTTCAATATTTTTCACATATGATACAATTTATTA +TGAGATTTTCGGAATTTTTTAAGTGAAGTTTTTCCCTAAAGTTTTCAAAA +TTGACTCGAATTTTCTGGAATTTTTTTTTTCAAAAGAAACACAGCTTTTG +TTTAATTTCCAGTTAATTTTTAGCTTTAACATTAAAAAAAATTTCTTTCA +TTTTTAACAAAAATTCCCCTTCTTATTTTAGAATTCAAAGCCAAAAACCT +TCAAATTCAATTTTATCTAAAACCTCCTCAAATTCGAAAAAGTGTGAGAG +AGATACGCGAGCTACGAAAAAGAGCAAAAATCTGAGTTTTTGAGCACTTC +>CHROMOSOME_IV +CCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCC +TAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTA +AGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAG +AAGAGACCAAACCGAAAAATCAATTTTTTAAACGAAAAATCAATGTTTTA +AACGAAAAATCTATTTTTTAAACGAAAAATCAATTTTTTAAACGAAAAAT +CCATAAAAAATTGTTATAAAAATTCTGGAAAAAAAACTAAAAACTTAATT +TTTGCTTTGAACATTCATCTTTCGCGAAAAAAATTTCAGCAAATAAAACC +GAAAAATACAATTTTGCAAATAAAAAATCTAAATCAACAGTAAAAAACAA +AAAAGTCAAATTTCAATAGAAAAAAAAATCAAAAATCAATTTTTACTCCA +AAAATTCAACTTTTGCCAAAAACTAACCCAGAAAAATCAATTCACAAAAA +AAAACAAATAAAACTGCAACGATGTTTGTGAAAAAAATTTTCTTGATATT +TTTAACGAATTTTTGTTTAAAAAAAATGCATTTTTGGCCATAAAATTTTT +TTTTTGATTTTTTCAAACGAATTTCCCCTCAATTTTCTTGCAGATCGACG +TGGATATTGACGACCTAGATGACGATTTTCTCTCCACAAACGGAATGGAA +CGACACGGTTCAGAATTACAAGGAGAAGTGGTTTTCACTACGACGAGTAC +TGCGAATAACAATGTGAAACGAGCCGTCGAATATTTCGAAGATGATAATC +AAGATGATGCACTAACATCCACTTCATCCGGCAACAGTACACAGAAGGAA +TCGTCTCCGTTCACAGATTTTGATGATGTTCCGCCGCCACCAGTGGCTCC +AGAAACTCCGGCTCCAGCCCAAAACCGCCGAGAATCTGCGTCCCCCGAAC +GTCAATTCCTTGATGAGAGTCACCTCGGCGGAATTGGATCTCCGTTATCA +CAGAGTACAAGGCTCGATGAGACGTTTATTGAGGAATACTCTATTGAGTT +GGACACCTCTGGGAAGTATGTGTTGGGAAAAAAAATCCGAAAATTGATTG +AAAAATTCGAAAAAAAATCCAAAAAACCTTTTTTTAATGAGATTTTTTCT +GTGCAAAAATTTAAATTTAGAGCTGAAGAATGTGCACTTCTAGAAAAACT +TATTTTAAAAAATTCACATCCTTTTATCAAATTTATTAGCATATTTATAC +AAATTGATGGATAAAAATTCCAAAAAAGTTCCAGAAACAACATTTCCTCC +GCAGCTTCACCTGGTCCCAAGTCTCCATTTGACGATGATTTTACTGATAC +AGCTGCCCCGGTAGCCCCGCCACCAGCACCTACAAAAGCTGCCGAGGAAT +ATCGCCGGCAACCACATCAGAATCCGTTTGATGAGGAAGAGGAAGAAGAA +TCACAGTTTGGAGGGGGAACTCTGTCCGGTAGAGACCCATTTGATGAAGA +TGTACGTTTTTCGTAAAGTTCGGAATTTTTAGGGTATAAATTGAAAAACA +AATGGAGAAAATATGAATACCTAGATTTTTTTTTTCAAAAAATCCCAACC +CTAATATCCACAATTTTTTTTCAGTCTGGAAACTCTAACGAAAACCAGCT +CCGCGAGAAGAAGCTCCACAAAAAAGAGCAACTAGCTCACCGGCTCTCCT +CCTCTTCCGAAGAAATTGTGGAAGCCTCAATTCACGAGGATGAGCCAATT +GTGATGGCTCAAATTCCAGAGGAGAAGCCCAAACCGAAGGCTATCCCGGC +TTTTGATAACGCCTATGACGCCGACTTTGACAATTCCCCACCACTTCATC +ATTACTCGGCGGTTCATTTGGAAACTGGGCTCTCACCGCTTGAGGAGGCT +CAGAGAGCTCTCCGAGCCAACCGAGCAAGGCATAAGCCGTCGAATGTATC +GTTGGCAGAGGAGGCGAAGCTTGCTGCCAGACAGAGATACTCGAATGCAT +CGGATATTAGAAGAGAAGAGGAGGAAGAAGTGGTGGAAGAAGATCCAGCA +GTGGTAGTTCCAGTTCTACGGAAGGATCTGGAAGTTGAGGAGGCTCCGAA +ATCGGTACGACCGCCTAGATATCGGAAGTCAAGGGAAATTGAGGAACCGG +TGGTTGTTGATCGGTTTGTTGAGGAAGAAGTTGATGAGAAGGAGGATATT +GATGCGATTTTTGAGAAATATCGAAAGGTTCGTAAAGATATTTTCGAGAA +AAACGGCGTTGAAAATTTGAAAAATTTGAACTTTTTTCGAGTTAAAAAAT +TTAAACATATAGAAAAGATATGAATCTGACAAAATTTAGAGAAAATAAAA +TGTTATTCACCAAATCGCCAATTTTTCTGCATTTTTTTGTCCGTTTTACT +TTGGTAATTCTGGTAATACAAAACTAGTTTTTTTTCAAAAAAGAATTGCA +GGAAAAATATTTTAAATGTTTTTTGAGCACTTGAGCGCATGAGATAGAAA +AACGTTATTATTATGCATTCCCTCATATAAAAGTTTGTTCAATTTTTTTA +ATTAAACCCCGCTCTTTGAGAAAACTCTGGACTCTACATGGAGACTACCT +TAATACAAATTAACTCATAAATATCGGTGATTTTCAACTAGTTATTCATA +TGATGCAATTACTGATTTAATAACTTATAATTATGTGTCAATTTCAGACG +TCTGTATCCGCCGATCCAAAATCTCACACGCCGATTTTGATGGCCGACGA +GTACAAAGAACCACAGAAGCAAGGTGAGTTTAGTTCGAAAAAAAATCATA +ACACACACCAGTAGGTTTAAAAACATTGTTAGAAAATTTGAAAAAAAAAC +CAAAAACCGTCGTAAAACTACACTTTTTCTATTGAAAATAGAACAAACAA +ATCAAATATCCTACATGTAAAATTTAAATCGAGTGGAATTAAATTCTTCA +AACAAAAAGAAATCTGCATTTAATATCGATTTCTCATTCAATTGTTATGA +ATCATAAAACATGATTTTTTACGACCTCCTCTGAATTATCTACATTGTTC +TCTTTTTCATACTTTCCATATTCTAGTATCGATAGGACTAACACAATTTT +AATAGTGAGTTCGTTTTTCAAACAATTGGGATTAATTTTCAACTGAACTA +GACTGTTTCTGAACGCTCAAAACCTTCAAAATCAATGCTTCTTCAAAACG +AAAAAATTGCACACTATAAACCTCTCACTTGAAGTGGCAGCGCTCGTTTT +ATATTGAGAAAATATATATTCAAAAAAATGCTGCTGCTTCTTCAGCTTCT +CGCCGGGCGCCGCCGCCAATAGTGAGTTCGTTTTTCAAACAATTGGGATT +AATTACAAAAAAACTTAACTGCGCAATTTTTAATTGGGAAACTTTCAAAT +TTTAACCATAACTATCAATACAGCGGTATACGAAATTTTTCTTCAAAATC +GCACCGATACTGCATTTTTCCGGAAAAGGACAAAGTCGGCTAATTGCCGT +TTTTTATAATTTTTGCTCATTAAGCTTATTCCATTAAAAATACAATTCTT +GTTTAAAATTGCTGAACGGCGAATTTTGTCTACCCGTGGTGGAAATTGCC +GGTTTGTTGATTTGCCGGAAAATTTCATTTTCGGCGTGCCGATTTGCCGT +TTGCCGGATATCAATTTGCCTGAAACGTTTAGAGGAATACAACGGAAACA +TTTGAAACTGTGCCTTTTTGAAATTTTTTCCCTTTTTTTTACAATATTTT +CATAGAATTAGCTTACTTTTCAAAATAGATGTAGGAAAATTCATATGCGT +ACAATTTTGCCAATTAAAATTTGAATTCTGAAATTTACAAAAAAATGTGC +AAAACTACTATTCGCCGAAAATTTTTGGCAAGTTGCCGATTTGCCCGAAA +TTTTTATTTTCGGCAAATTGGCGCTTTGCAGTTTGCCGGAAAAAATTACA +TACACCTGTTTTCAGCCTAACTTAAAATATGATTTACTTTGAAAAATAGG +GAATTAAATTTAAATAAAATTTTCAACTGAACTAGACTGTTTCTGAACGC +TCAAAACCTTCAAAATCAATGCTTCTTCAAAACGAAAAAATTGCACACTA +TAAACCTCTCACTTGAAGTGGCAGCGCTCGTTTTATATTGAGAAAATATA +TATTCAAAAAAATGCTGCTGCTTCTTCAGCTTCTCGCCGGGCGCCGCCGC +CACATTTACCGGCCAACCCGTTCTCTGAGGTTGTCTTGTAAGGGCGTTTT +CATGTATATTCAGATTATTATGCATGAATTTCATTAATAACGGTATCCAC +CCACGTATATTTCTCTTCTTCTCTCTTTCTGTTGCGACGGGGGATGTCGA +TTGATTACGCCACGGGCGCTAGCCTATTCCGAATGCATTGAGAAATTTGA +GACCAGATTCTGGAGTTTTTGGAAGACGAATCGTCGGCAGCGGAGCTCGA +TTTTAATTTAATTTCGAGAGCACCCGCGTGCTCTCGCCTCGACACCCTCA +AACTTCTTCTTCTTCTTCTTTTCGTCGTCTTTCACTTTTTTCCTTTTTCC +TGTCCTAACCACGGCGTCTTCCTCCAATTTTCAGTTACCACGACGTCATT +AGCTATTTTTAGTCCGAGTGTGGAGCTTGAGAATTTGAGCAATTCTGATG +TGACATTCCTGTCGTTTTTAGCGCTAATTTTCCTAAAACCTTCAAAAATT +TAGAAATTCTCTATCGTCTTTCAAGAGCCTAAGTTTTTTTTTTCGAAATG +AGTTTTTTAAAATTGATCGAAATGTTTTTAAATACTGAATATTTGGGATT +CTAGATTTTTACTACAATATTTCCTTTTCAATTTTTAATTGGACAAAATT +TCAAAATGTTAAAAAAATTCTCCGAATTGAATGCTATTTTTCTAAAAAAT +TTTTTTAGTGCCTGCACCAGTTGTCGTTGCTCAGGAGTCGCCGATCTTAA +AACGAAGAAACTCTCTAGTACCATCAAGGATCAGTGGAAGGCAGTCGACG +>CHROMOSOME_V +GAATTCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCT +AAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA +GCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCATAAGC +CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCATAAGCCTAAGCCT +AAGCCTAAGCCTAAGCCTAAGCCTAAGCATAAGCCTAAGCCTAAGCCTAA +GCCTAAGCATAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAACA +TAAGCCTAAGCCTAAGCCTAAGCCTAAAACATTTGGAAATTATTTTTGAT +CGTTTATATTCAAGTAGCAAGAAAGTGTCCTAGCGTTAAAAATAGGAAAT +TTTTCGCTCTTTCAGAACAGTATACTCATGTCTCTGTACCGACGATATTC +ATTTCAAAAATCGCAAAAAAAGTTTTTTTCAAAATACCACTACCATTAAA +ACATTTGGAAATTATTTTTGATTGTTTATATTCAAGTAGCAAGAAAGTCT +CCTAGCCTTAAAAATAGGAAATTTTTTGCTCTTTCAGACCAGTATACTCA +TGTCTCTGTACCGACGATATTCATTTCAAAAATCGCAAAAAAAGTTTTTT +TCAAAATACCACTACCATTAAAACATTTGGAAATTATTTTTGATTGTTTA +TATTCAAGTAGCAAGAAAGTCTCCTAGCCTAAAAATAGGAAATTTTTTGC +TCTTTCAGATCAGTATACTAAACATTCACGTGTGGATTAAAATTAAAAAG +GTAGTGTTAAATAATTAAAAATCATTTAGGGGGGAACGAAACCCATAAGT +ACTGTCATTTTTATCTTTTACCTTTTTTTTTACGTACGACGTTTTTCGCT +GTTTTCCCTGATACAAAATGCGTTGTTCTTGTTTATTTATGTTTTTCTTG +AAAATGTTATCAACACTGATAATCTGAAAAATTATAATTTAAAACTTAAA +CGAAGCTAAAATGTGGCTGTTATAATACAGCGACTCAATGAAAAACTCAA +AAAAAAGTTGACTTTGCACGCTATGGTTAAAAATGAATGAATTCTTGGTA +CATGGTTTTTTTTGTGATTTTTCGTTGAAAAATCCACACCGTGTCAGAGA +GAGCTGAAAATGTTCATTGAAAGCGCTAAAAAACATTTGAAAAAATGCCA +ATTTTTCCGTAAGATAATTCGATTTGAAAGTTTGAAAACTGAATAGTAAT +TGTGTACTTGCAAAGAACCTTGTTTGCTTTTTAGTTTATTTGATCTACCA +AAGATTGGGTTCACTGTCTGACCATTTGGGTCACTAATCTCATAAACCGT +CAAAACAATCCAACGTGGTACAAAGTACATCAAGTTTTTCACAAGTCCTA +TAGTTAGCTGCGCATCCCTAATAGGTATCCCCATTAATTTTTTTTTCAAG +AAGAATGGCAACACAAACACCCCTCTCTGATGACTCGTGTGTCAAAAACG +AGCTCACGGAACTCTCCTCTAGTGAAACGGTCTCGAGGATTGACGAGGCC +CCGAAATTTCATGTCAAAGCTGTCGTCGGGCGTGTTGTGATAAAACATTT +TGGTGGCCGGGATTGTGTTTGTGTTCAGTCAGAAAGACGCTATTAGGACC +TCCTCCCATCTTATTAGCTGTTTATCCTTCATCACAAGACATCTCAATAT +TGGTTCCATAGGTGTAGCTTCTTCTGCTTCTTCTTCTTCTTTTGTACCTA +CGTCATCATACATTGGTTACTGTCCTACCGAGGTTTGTTTCAAATTTGCA +CATTTAAAATGGTATACACCTTTAAAATAAACTTAGAAGTAAGGCCTTTG +GTCCCACTACAAAAAATTTACAGTAGTTTGGTTCAGACTTTTCTAAATTT +AATTAAGGTTATTTTTTATTGACAAAAAATATTTTAGTTCAAGAAATATG +TTATGTTCAGTGGGTTTCCTGTCATATACTTCTACTTACCGTATTTCCTC +TATTAGTCTTGCATGCAAGACTAATTTTCAATTGACCCGTAGGGGTGCAA +GACAAATAGGGGTGCAAGACTAATAGAGGCTGCAAGACTAATAGAGGAAA +TACGGTAGTTATACTGGCAAAAGCGATAGCATTTCGAGAGAAAAATATTC +TTAAATGTGCTCAATATGGCTGATACAGATAGGTTTTTCATTACAGACAG +GTTTTTCATTTCAATTTTAAAAAAATACCTGACAGTTTATCAAGAAAATC +CAGCACATTCCAGAGTTATTAGAGTATTTAGAAGTTTGCAAGTTCCCAAT +TTTGTCAAGGGATTTTTCAAAGTTTCTCAAACTTTCCAAAAAATGCAAAA +AAAAACATTCCAAAAGTACCAATTTTTCCAAAAAATTCCATAAATATATT +CAGTCCACCGAACGTTTTTAGATCTAACTGAGAGTTCTCCTGAAGTTTTT +CAGAGTTTGAAGGAATTTATAGAAGTTTCTGATGTTTTACAGGATTTTAC +TAAAGTTTCTCAAATTATCTATAAATGCCAAATCTTTTCAGAAAGTTTTC +AGAAAATTTCCGGAAAACCTTCAATTTTTCAAGTTTTCCAGAAGATTCTC +GATTTTTCCAAAATCGTTTCAGAATTTTCCTAATTATTCCCATATTTCCA +TCGACTTCTTATAGTTAATTTGATTTTCATCAAATTGATACAAATGAGAA +AATTTGAAATTTGATAACTCACGTTTCGATGCAAAAAGAGACGAAAGGCG +GCGTGATGCGGGCAGGATTTAGGCAGGCGGTAGGCCCTGAAACCGCGCCT +GCCTACCATTGAACCTCTAAGCTATTCAGTTGTATTTTTTGATATTCCAG +ATGCGTACCGACGTGGGTTCTATTCCATTAATGTGTATTCTGTCTACACT +AACGACTGGTGTGTTCGGATATCTTCCGACAGAAGATCTCACAAATTCGA +TAATTTCTGGAAACGGTGGTTATCCAGTTCCTCCGGACACTATTATACCG +GCCGATGGAGATGAGGAAGGTAAGTGGATCAGAAATTAATAATTATAAAT +TTTTTAGAGTAGGGTTTTCTTCTGAAATCTGATATTTTGTGAATTTTGCA +AAAAATTGGAAAAATCGACAACGAAATGCAAATTGTTTCGTTAAATGCAA +AATGGATGCGCACCTTTAAAGAGTAAAGTCTATGAAAATGCTTTTATTTG +GTATTACAGTTCTTTTCAAAGGCACACATATTTTTCCCATTTAACAAAAA +ATCGTCGTGACCTTATATCGTATTTTCGGCGCAAAAATCGGAACATTTCG +CGTCTGTATAATACCCCATTTAAAGGTTTACGACGCAATAATACAACACC +GGGTCTCGACGTGGCAAACGATTGTTTATTGATTTTCACGGGATTCTCGC +CTTTCTCATTGAATTTTCGCGCTCCATTGGCAATCGCCTGCCGGACAACG +CGTGGAAAAGTGTAGTGTACTCCACACGGACAAATCCATCGGTTTTACAA +CTAAAAACGAGCCGCGACGCGACACGCAACGCGCCGTAAACCTACACAAA +ATCTCGCAGACTCAAAATGGCCTAGTTCGGCAAACTCTGCCATTTCGATT +TATGAGGGAGGCCAGAATTCCGTGATTTTCCCATTTCTCACGGCCTCTCT +AAATTTCACGTTTTTCAAAATTCATCTTTTTCTCTCTGCTCTCTCACTCT +CTCACGTGAAATATTACTTTCTGAATAATAATTTGTGTTTAATTAAATCA +AATTTTATTGAAATAGAATTCATGATACACGATCTTGAGAAGAGCTCTGT +CCTCCAGGCTGCGAACTGGAGCGTAGAAAGTTTTCATATTGTTAAAAACT +GCAAAGAAATGTTCGATTCCTTGTTCTGACGTGTGATGCTTTCTCAAATA +TGGAATTAAATGACAGACAAGGAGATGAAGTTTCGGAGTGACTCATTATT +TCATCAGTTTCATTAGGAAAAACACTCTTTATTTATTCAAGGAACTGTTA +AAGCAAAACTTCAATTTTGTCAATCTCTTGGTCTAAATACGTTCTATCGT +TAGATAAATCTAACTATCTAACTGAAACGAGTACAACTATATTGTAACGC +AAAAAAGCTAAGCGCCATAAAACACAAGTAAAACAGGCTCCAGTAAGCCT +AAACTGTTTTTACTATAAAAAACCATTGTCATTCACCTACCTACCAAATG +CCAATATAATTGGTTGAAAAAAATTAGTTTAATCTCCTCGCAAGATTTTT +TTCTCCGAAATTTAAGATTGGGCGCTTAGTGATATCATAACTCTGCAGCC +ATCAGAAAAACTGAAATGTATTTAAACTGTAAGTTTTAATCGTTTTATGA +GGATTATTTCTTTAGTTGACAGTTTTTTGATAGCTTCTTTAGTTATTGAG +CTACGGGCTTCCAAACAAAACCAATCAAAAACCACTATAAACCACAATGT +CCTAAAAGTGAAATTACTCAGTCAATTTTTAACCAAATCACGGCATTAAT +GTCTTGATATCTTCATTGAACAATTTGTAAAAATCGTAAGGCGGTAGTTT +TTTGATAAATGTCATCGTTTTTTAGTAAAATTGCGTTAACCATTCAAAAA +TGGCCCATTTTTGGTGTTTTCAGGCCTAATTCTTGTTTTTGAAATTCCGG +AGCCAGTTTTTATCGAAAATTTTTGTGCAATGTCAAAAAATGACCGGAAA +AAAATTCTCTACAATCGTAAGGCGGTACTTTTTAAAATTTCGTTTCCATT +CTTCCCCAGGGATCCCGTAAAAAACCAATTTTTCGACTAGGTCTCACATT +TTGCCCTACAAGAGCATAGTTAATGTTATAAATTTGGATTTTTTGGTCGA +ATTTGATGAGGTAATATTCAGTTGTTTGTTTATTGTTGGAAAATCTGAAG +ATTTATCAGCGAATCGCCCGATTTCGCCAATTATGACCAAAAAACCCCTA +GTTTAGGATTTTCACGAATGGATGAGTTCATTGATACGCTTCCACGCTGT +>CHROMOSOME_X +CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCT +AAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA +GCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGC +CTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCT +AAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAAGCCTAA +GCCTAAGCCTAATCTGTGCTCCAAAGCCTTCGAACTGACGGACTTGTGTC +CCGAAGTCGAACTCTTGAAGTTGTCACCGAGTTGGCTAATAAGAAAGACG +CTACGTTGTCTTTTTAGTAAGTTTTCGTCGAAATTCTGGAAAAAAAATCT +GAAAAAAATGAGAAAAATTGAAGTTTCTTGTGAAAACGTGCAGCAGCCGA +CAACTAACGGGACTGGGAAAATTGAAATTTTTAACACAGTTAAAATGCGA +TGTGCGCATAGTGGGTGAAAGGCCATAATGCGCGCACCGCGTGTGGCGAC +CACCTATTATGCACCTATCGCGAACGGTTCGCGATGGGTCCATAATGTAT +CCATGATGCTTCCACTCACGAAACAAACAATTCGAAATATATATTGTTTT +TCCGCCTATTTTTTTAACATTTTATTGCAATTTTTATTGAATTTTTGATT +TTCACTGGTTTTTTTTCTTGAAATTTTGTTTCGTATGTGGTATTTTGTAA +TAATCATAATATTTTTTTCTAAATTGTGTGTCTTTTAGAGAAAACACTGC +TCTAACCAGTTGAGGCATTTAAAAACATCATTTAAACAACATGGCAAGCA +TTATTTCGTTCCTAATAAATGGAAGCATAGTCAGGATTACTGTAGTTTCA +CATGTATTTAGCCATTAAAATTGTAATCTGAGTTTTCATCGGTATTTGCG +CATACTCAGAAAATTTTGTTAAATATCTTGTCTGTTCCTGTATTTTCAAG +AGCGAAATATCGTCAAAATCAGATTATTTCGTTGAATCTGGAAATGCCCA +CTGTTCTTCATGCCTACTCGTGTCTATTTCTCATCAGCGTTATAACTCAC +CTTTTAAATAATATTGTAGAAACAAATTTTTTGCAGCTTCTCTTCGAGCA +GCAGACTTCACAAAAACTTCATCAACAAGAAAAAACGTGAAAATCTTCAA +CATCGGAATGTCTAGGTGAAGGATGTCGGAACGGGCAAGGTTTGGAGCAC +GGCTCAGCTTTTTTAGATTTTAGATTTTAATTTAGAAACACACCACCGAA +GAGGAGGAGATAAAGATGGCTCGGCTCCAGAATGCATTGAAAGTTGTTGG +ATGGTCGAATGGATTGAAAGCAATTGTAAAGAAGGAGTTACCCGGAAGCC +CTGCCAAAAAGCAAAAACCGGCATCGGTTGCGCCGAAAATTTTGGACTCC +TCGATCGGAAGAGTGAGTTTGCTGATTTTCAAAAAATAGGATGAAAGGCT +GAATAATTTGAGCTCTCAATTGCTAAAAATATACGGATGGACAAAACTAC +GATCATCATTGGTCACAAAGTTGCAGCTCCGAAAAGAGAATTCGTCTGGA +ATTCTGGAAGTTCACAAGAATGGTGAGTACTTACCTTTCAAGTGAAAATT +GAGGAAAAATTGAGAAAGAAATGTGTTGAAAGATGCAAAAAAATGACAAA +AATTCAGCTTATCCTGCTAAAATTACGCGTGAAAAAGCATATTTTGTGCT +TGAAAATCGCAAAAAAAATGCATTAGAAAAACCGATTTTATTTAGTCCTC +CTAACAAATCGATTTTTGTAGACCTGGAGTCATCCTAGCAAACGAGGCAA +CACTGGAAGAGGACGAAAAACGTTAAGATTCCGTATGAAGATGTCAGAAA +ACCGAGTTAGGAGGAACTTGGAATTAAATTTTTGAGTTTTCTTTTTTCTA +TAATTTTTTAAGCTCACTTTTTATTCTTTTTGTTGTTCTCCCACTTAGGC +CATGTTAATAAATGTGTTTTTGTTAAGAAAACTGTCTTAAATGCTCAGGA +TCAGGTTTTATTATTAAAAAAACAAACCCACAAAGCGCACATAATTTATG +TTCGCGATGCTCGCAAAATGCATCTCAAGTTCGCGATGGACGCACAATGC +GCGCGCAATGGGCATCATTTCCGGTTCCTTTTTAACACACGCGCGATCCA +CTCCGAAAGCACTATGCGCACATCGCATTTTAACTGTGAATGAAAATTTG +AAAAAAAAAACTAAATTTGAGAATTTTTGAGTTAAAAAATTCCAAATTGC +AGAGAAATAAAAAATAAAATTTTTAGAGAATATATCGAAAGAAATTCAAA +TTTTTAAGAAAAAATCCCAAAAATAAATCATTTTTCTAGAAAAAAAAAGC +AAAAAGTTCCCATTTTGCGATAAAAATCGAAAAAATCCCGATTTTTTTAC +AATTTTCTAAAAAAAAACTGAAAAAAATCCACATTTTTCAGAAAAAAACG +CTAAAATTTTAATTTTTTCTAGAAAAAAACAAAATTTTCAATAAAAAATC +CAAAAATAAAACCAAAATTAAAAAATTATAATAATTACGGGTAAAATCGT +ATGAAATCCCGTTTTTTTTTTAATCGTAATTATTTTCAATTTTTTGGTTT +TCTCCTCAAAAAAAATTGTTTTTTTTCCCATTTTTCTTTAAAAATTGAAA +GTTTTCCAATTTTTCTCGAAATATTGACTCAAAATTAGCTTTTTCTTCGA +ATTTTTAATAAAAATTTTCACTTTCGCGACCCGTTAGTTGTCGGCTGCAC +GGTTTTCTGAAAATTGAGAAATAAAATTAGAAAAGTTGCAAAATTGAAAA +AAAAAACCGCAAAAAACTGAAATTTTCTAGGCAAAAAAAAATAAAAGAAA +TCCACAAATTTTTCGATAAAAATTGAAAAAATCCAAATTTTCCTGAAAAA +AATCCCAAAAATCCAATTTTTCTACAAAAAAAACCCAAAAATCCACTCCT +TTTCGATAAAAATTTGAAAAAATTTCGATTTTTCAAGAGAAAATTCCGAT +TTTCTAGAAAAAAAACCCCAAAAAACTATAATTTTCCTTTAAAAAAAACC +CCAAAAATCCAAATTTTTGTACAAAAAATACCAAAAAATCCACATTTTTC +AATAAAAATTAGAAAAAAAAAACAATTTTTGCTGAAAAAAAACTCAAAAA +TCCAATTTTTCTACAAAAAATACAAAAAAAATCACGATTTTCCTGAAAAA +AACCCAAGAAACTATAATTTTCCTGAAAAAAAAATCCAAAAAAAAACCGG +GAAAAAAACAAAAGAAATCCAAATTTTTCGATAAAAAAATTGAAAAAATT +CCGATTTTTCAGGAATAAATTCGGGAAAAAATTCAATTTTTCTAGTAAAA +AACCCAAAAAAAACCCAATTTTTTTGCAGTTTCCGTCACTTCTTCTACCA +CCGTTTCCACAGTAATCTCATCGAAGGCTCAGGTCGCCTACTCGACAAAA +TTAATGATACTACTGCTGCCCAACAACAACTACAAACTACAAACGAACTC +GACGGCGATGGCCCAGAAATTGCAATCGCCGCGGCCAAAGCATTCCATCC +GACTGAAAAATTCGATTTGGAAATGAATGTGGACGACGATGAAATTCTGA +AAGTATTTGATATACAAGAACAAGAGCAAATTGTGATGAAAAAAATCCGA +CATTTGGAGAATTCTGACTTACATTTCGAGCGAATTCATGTGAATTTGGC +GAAAAAAGAGCGATTTTTTGACGACGTTCAGAGCTCGGAAAATGACTCAA +GCGACGAAAAACTCGCCGAAATTTGCGATTTTTTGAGCCAAAATTGCCGG +GAAATCTCGAATGCTGCGAAGCCTCCTCGAGCAACACTTGACGAATGGAT +TCAGACTGGAAAATTCGAAATACAACGTCGTCGAGAGATCCGGGCGGTTT +GCCACGTCATCAAGGCCATCGGTCAGATGGGAATTACACTTGGCGAGCTG +TGTGGAAAATTGAAAATTGCCATAGAGCAAATTGCCGGAATTTTGGCCGA +TTTGAGCGGAGACAAGAAATGGTGTCCGAGACCTTGGATTGCGCCGGAAG +GTTTTCTTTTTTTTTTAAGGGATTTTTGGGGCGAAAAATTTGGATTTGGC +TCACCACGCGCGAGCTTTGATTTAAAGGTGTTTTCGCGGTGAGACCCGGA +AATTTTATTTTTCCTAAATCTCTCTGAACCCGGTCATGATTATACTTAAA +TGAAAGCTCACGGCGAGCTGAATTCGAATACTAAGTGTATGGTTGTTTAG +CTACAGTAACCTGACACTGAATTTCGCGGCGAGACCCGAAAATCCCCAAA +AACTCTCAAAAACCGTCTTAGAATCGATCAAAATATGTCAAGATTATACT +TAAAGGAGGACTAACGGTTCGGACGATTTTGAACGTATAGACCAAAAATA +AGCTCAAATGAACGAAATTCGTAATGAAACTGCTCAAAAATTTTTCAAAA +ATTTTTTATGGCGGTTCAAAATTTTGAAAAAAATTACACTGATTTTGGCT +AAAATCACGATTTTTTCTCATTTTTCCGTGTCACATTTGTCCGAAGTTGG +TTTTTTTAGAATTATCGTCCTTTATTACATATTTTGGTAATAAATCTCAT +TTAATTTCGTCGATTAAAGTGCATTTAAAGCCGATAAATAACCAGTTTCG +ATGATTTTTGGTTACCTATCGGCTTTAAATGTACCTTAATCGATGAAATT +AAATGAGATAATCTACCAATATATGTAATAAAGGACGATACTTCCAAAAA +AGCCAACTTCGGTCAGATGTGACACGGAAAAATGGGAAAAATTCGTGATT +TTAGCCAAAATCAGTGTAATTTTTTTCAAAATTTTGAACCGCCATAAAAG +ATTTTTGAAAAATTTTTGAGCAGTTTCATTACGAAATTCATTTAAGTATA +ATCATGAGCGGGTTCAGAGAGATTTAGGAAAAATAAAATTTCCGGGTCTC +>CHROMOSOME_MtDNA +CAGTAAATAGTTTAATAAAAATATAGCATTTGGGTTGCTAAGATATTATT +ACTGATAGAATTTTTAGTTTAATTTAGAATGTATCACTTACAATGATGGG +GTTTAAAATTCTATAGTAAAAGTGTTTTTTGTTTTAGCTGTTTTAAGTAG +GATTATTAGATATATTAATATTGACCCTATAAAAAGAAGTTTTTTTCTTA +TCTTTTCACTACTTTTTAGTATACCAGTTATTTCAATGAGAATACATATT +TGGTTTTCTTACTTTATTTGTTTATTATTTTTAAGTGGTATTTTTGTTAT +TTTGGTATATTTTTCTAGTTTATCTAAAATTAATGTAGTGAAAAGTTATA +TAGCTGTGTTTTTACTTTTGTTAAGAATGTTATATTTTTCTCCCACAGTA +TTAACTTATAGAAGATATTTAGGTTTAAGAGGTTTTTATTATAGTATTTA +CTGGTTTATTTTTTGTTTTATTTTAGTATGTTTATTATTTTTTATAAATT +TTAGTAGTTATTTTTTAAATTTTTCAGGTGCTTTACGTAAAGTTTAAAAT +TATGTTTTTATTTGTTAGATTATTTATATTTATTTTTAAATGACAACGTT +TAATTTTTATTCTAATTTCTTTAGAATTTATAATGTTGAGATTATTTTTA +AAATTTTCTTATGTTTTAGGGGAAATAATGTTTTTTTATTTTATGTGTTT +TTCTGTTATTTCAAGAATCCTGGGTATGGTAGTTATAGTAGGTAATATAA +AATTTTTTGGTAGTGATAATTGTATTTTTTAGTAACAGATATAAGTTAAG +TTTAAACTATTGATCTTCAAAATCAAAAATTTATTTCTGTAGAGATAATA +GTATAAATAAGTATGTTTCTTTTTCGCAGAAATGGTTTTTTATCTTATAA +AGTTTTCTTTCAGGGAATTAAAATTTGATCATGGTTTAAGATGATTTAAA +ATGGTATTATCTAAATTTGATTTACAGAGTAGGCAATAAAAATTTACCTC +GGCAATTTATCGCTTGTAAAATACTTGTTCCAGAATAATCGGCTAGACTT +GTTAAAGCTTGTACTTTAATTGATGTTAATTATGAAATTATTATATTTTC +TTTTAGATCTATGGTAGAATTTGGATTTATATTAGTGAATTTTCATAATT +TTAAGATTTGTTGAACAAAGCAGATTAGTACCTGGTTAGACAAAAATTAA +AAGAGCAGGAGTAAAGTTGTATTTAAACTGAAAAGATATTGGCAGACATT +CTAAATTATCTTTGGAGGCTGAGTAGTAACTGAGAACCCTCATTAACTAC +TTAATTTTTTGACTCGTGTATGATCGTTTATTTTATTCTTAAGGATTATA +ATAAAAAATTTTTAATTTATTAAAATAGATATATACCCGGTTTATGATTT +AAGAAACATTTGGCCTACAATATTTTATATTATGGATTTTAGTTTTAGTT +AACTAAATGAAATTGTAAAAGACAGTAAAAAATTCTTAATGTATTTTTGA +AGATTATCTAGAAGTGGTACAAATCATCCATCAATTGCCCAAAGGGGAGT +AAGTTGTAGTAAAGTAGATTTAGGGGAACCTGAATCTAGTAATAAAACTA +TTTTTAAATATGTTTTGAAAACATGTTTTGAGGTAACTCGTAGTTTTTAA +GAGTTAGTTTAATATAGAATTGTTGACTGTTAATCAAAAGGTGTACCTCT +TAATATAAGAGTTTAGTTTAAGTTAAAACGTTAGATTGTAAATCTAAAGA +TTATTGCTCTTGATAATTTTAGTTTTACTTATAGTTATTTTAATGATGAT +TTTTATTGTTCAAAGAATCGCTTTTATTACTCTATATGAGCGTCATTTAT +TGGGAAGAAGACAAAATCGTCTAGGGCCCACCAAGGTTACATTTATGGGA +TTAGCACAAGCTTTATTGGATGGGGTTAAACTTTTAAAAAAAGAACAAAT +AACACCCTTAAATTCCTCTGAAGTATCATTTTTACTTGTACCAGGAATTT +CTTTTGTTGTAATATATTTAGAATGATTTACGTTACCATATTTTTTTGAT +TTTATTAGTTTTGAGTATTCAGTTTTATTTTTTTTATGTTTAATTGGATT +TTCTGTTTATACAACTTTAATTAGCGGTATCGTAAGAAAATCAAAATATG +GTATAATTGGGGCCATCCGTGCTAGAAGACAAAGAATTTCTTATGAAATT +GCTTTTTCTTTATATGTTTTGTGTATTATTATTCATAATAATGTTTTTAA +TTTTGTTTCAAAATTTAATTTGAGACTTTTAATTATTTACATCCCATTTT +TAATTATAGTAATTGCTGAACTTAACCGGGCGCCATTTGATTTTTCTGAA +GGTGAAAGGGAGTTAGTTAGAGGATTTAATGTGGAGTTTGCCAGAGTAGC +TTTTGTTTTATTATTTTTAAGGGAATATGGAAGATTAATTTTTTTTAGGG +TACTTTCTTCTGCTATATTTTTTAAATTTTCAATTTTTATAGCATTTAGT +ATTTTTTCATTATTAATTTTTATTCGTAGTTCATACCCTCGTTATCGTTA +TGATTTAATAATAAGTTTATTTTGATTTAAACTTTTACCAATCTCTTTAA +TTATATTGTGTTTTTACGCAGTTATTTTTTATTATTAATCAAGTTTATTT +TTTAGACATTTTTATATTTGTTTTTGTTTTACAATTTTTGTTTTATTTTA +AAGAAAGTATATTAAATACTTTAGTGAAAAAATTTCTTAATAGGTTAGTA +GGAGTATTTAGATATACAAATACTTTACCATTAAGGTCAGTAATTTCTAT +TTTTACTTTTATTGTTCTTTTAACTTGTTGTTTTGGAGGTTATTTTACTT +ACTCTTTTTGTCCTTGTGGAATGGTTGAATTTACTTTTGTTTATGCTGCT +GTAGCGTGATTAAGTACTTTGTTAACTTTTATTTCAAGAGAAAAATTTTC +AGTTTATATAAGAAAACCAGGAGACACATATTTGAAAACTCTTAGAATGC +TATTAATTGAAATCGTTAGAGAATTTTCTCGTCCACTTGCTTTAACAGTG +CGTTTAACAGTTAATATTACTGTTGGTCATTTAGTTAGAATAATGCTTTA +TCAAGGATTAGAATTAAGAATAGGTGATCAGTATATTTGATTATCAATTT +TAGCCATTATAATAGAATGTTTTGTTTTCTTCATTCAAAGTTATATTTTC +TCTCGTTTAATTTTTTTATATCTTAATGAGTAATAAAAAAAAAAAGATGT +TAACTTAAGTTTTAAAGTGCCAAACTTTTAATTTGGAAATGGTGGACCAC +ATCTTAGTTGATATAGCATAAGAAGTGCATTTGTTTTAAGCGCAAAAGAT +ATCCGTCAACTAACGAGTTCATAAAGCAAGTCTTCTAAATTTGTTCTAGG +TTAAATCCTGCTCGTTTTTGATTGTTTTTATTTCTTTATTTACCTTGTTT +TTAACATTATTAAGAATTTTGACTAATAACGTTATTGTTTGATGAAGAAT +TTTTTTATTGATAACTGTAGTTTTTATTCTATTAAATAAAAGCAGCAAGA +GATATACCAGAATTTTTAATTATTTTGTTATTCAAGAGTCTTTAGGTTTA +TTATTTCTTCTTTGTAGAGGAGGTCTATTACAATTTTTTATTATTTTATT +GAAAATTGGTGTAGCACCGCTCCACTTTTGAATTTTTAATGTAACAAATA +ACATTTTTAATTATGGGCTAATGTGGTTTTTAACATTTCAAAAATTACCA +TTTTTAACTATTTTATTACAAATTTTTTGGTTAAGATCCGTGTATATTTT +GTTATTTGGTTTATTGATTTGTTATGTTCAAATTTTTGTCATAAAAAGTT +ATAAAAATTTGTTAATTATTTCATCCACAGAGTCTTTTAATTGGATTGTT +TTGGGAGTATTTTTTTCAATGTTTAATACATTTTATTTATTTATTTATTA +CTTTGTATTAATAGTTTTATTAATTTCTAAGTTTTCTAAAACTAGGGGTT +ATAATTTTATTAATTGAGAAACAACATTAGTATTTTTAAATATTCCATTT +AGAGTTTCATTTTTTGTAAAAATTTTCTCATTGAGGGAAATTTTTAAATA +TGATAGATTCTTTACTCTATTTTTGCTTTTTACAATATTTTTATCTGTAT +TGGCATTTAGATTTTGATTAATTAACTTGAGAATGAAAAATAATGAAGAA +ACTTCAAATAATAATAAAATAAATTATTTTATTATTTTTCCGTTAATAGT +TATTTCTATTATTTAATTACTTTTCTAGTAAAATATATTATATTATCTTG +ATAAGGTAAAGTTCCAGTTGGGAGAAGTAAGATGTAAAATAGATATTACT +ATGTTTGGTTACGGTCCAAAAAGATGCACATCTTTGCGATCTAGTTTAGA +AAAAATATTTGTTTTTGGTGCAAAAGAGTTTGATTGCATTTAGTTTACTC +TTTTAGTTTATAATTAAAATATGGCCCTGAAGAGGCTAAGAATATTAGGA +GTATTGAAAATTAATAATAGATTATTAAATTTTGTTAATGGGATGTTGGT +GACATTGCCATCTAGAAAAACTTTAACATTAAGATGAAATTTTGGTAGTA +TATTGGGTATAGTTTTAATCTTTCAGATTTTAACAGGTACATTTTTAGCA +TTTTATTATACGCCCGATAGGTTAATAGCATTTTCAACAGTGCAGTATAT +TATGTATGAGGTAAATTTTGGATGAGTATTTCGAATTTTTCATTTTAATG +GGGCCAGGTTATTTTTTATTTTTTTGTATTTACATATTTTTAAAGGGTTA +TTTTTTATAAGATATCGTTTAAAAAAAGTATGAATGTCTGGTTTAACAAT +TTATTTATTAGTAATAATAGAAGCTTTTATAGGTTATGTTTTAGTTTGAG +CTCAAATAAGATTTTGAGCAGCAGTAGTTATTACTAGACTTTTAAGAGTT +ATTCCAATTTGAGGGCCAACTATTGTTACTTGAATTTGAAGAGGTTTTGG
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/ce.fa.fai Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,7 @@ +CHROMOSOME_I 1009800 14 50 51 +CHROMOSOME_II 5000 1030025 50 51 +CHROMOSOME_III 5000 1035141 50 51 +CHROMOSOME_IV 5000 1040256 50 51 +CHROMOSOME_V 5000 1045370 50 51 +CHROMOSOME_X 5000 1050484 50 51 +CHROMOSOME_MtDNA 5000 1055602 50 51
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/compare_sam.pl Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,172 @@ +#!/usr/bin/perl -w +# +# Copyright (C) 2013 Genome Research Ltd. +# +# Author: James Bonfield <jkb@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +# Compares two SAM files to report differences. +# Optionally can skip header or ignore specific types of diff. + +use strict; +use Getopt::Long; + +my %opts; +GetOptions(\%opts, 'noqual', 'noaux', 'notemplate', 'unknownrg', 'nomd', 'template-1', 'noflag'); + +my ($fn1, $fn2) = @ARGV; +open(my $fd1, "<", $fn1) || die $!; +open(my $fd2, "<", $fn2) || die $!; + +# Headers +my ($c1,$c2)=(1,1); +my (@hd1, @hd2, $ln1, $ln2); +while (<$fd1>) { + if (/^@/) { + push(@hd1, $_); + } else { + $ln1 = $_; + last; + } + $c1++; +} + +while (<$fd2>) { + if (/^@/) { + push(@hd2, $_); + } else { + $ln2 = $_; + last; + } + $c2++; +} + +# FIXME: to do +#print "@hd1\n"; +#print "@hd2\n"; + +# Compare lines +while ($ln1 && $ln2) { + chomp($ln1); + chomp($ln2); + + # Java CRAM adds RG:Z:UNKNOWN when the read-group is absent + if (exists $opts{unknownrg}) { + $ln1 =~ s/\tRG:Z:UNKNOWN//; + $ln2 =~ s/\tRG:Z:UNKNOWN//; + } + + if (exists $opts{nomd}) { + $ln1 =~ s/\tMD:Z:[A-Z0-9^]*//; + $ln2 =~ s/\tMD:Z:[A-Z0-9^]*//; + $ln1 =~ s/\tNM:i:\d+//; + $ln2 =~ s/\tNM:i:\d+//; + } + + my @ln1 = split("\t", $ln1); + my @ln2 = split("\t", $ln2); + + # Fix BWA bug: unmapped data should have no alignments + if ($ln1[1] & 4) { $ln1[4] = 0; $ln1[5] = "*"; } + if ($ln2[1] & 4) { $ln2[4] = 0; $ln2[5] = "*"; } + + # Rationalise order of auxiliary fields + if (exists $opts{noaux}) { + @ln1 = @ln1[0..10]; + @ln2 = @ln2[0..10]; + } else { + #my @a=@ln1[11..$#ln1];print "<<<@a>>>\n"; + @ln1[11..$#ln1] = sort @ln1[11..$#ln1]; + @ln2[11..$#ln2] = sort @ln2[11..$#ln2]; + } + + if (exists $opts{noqual}) { + $ln1[10] = "*"; + $ln2[10] = "*"; + } + + if (exists $opts{notemplate}) { + @ln1[6..8] = qw/* 0 0/; + @ln2[6..8] = qw/* 0 0/; + } + + if (exists $opts{noflag}) { + $ln1[1] = 0; $ln2[1] = 0; + } + + if (exists $opts{'template-1'}) { + if (abs($ln1[8] - $ln2[8]) == 1) { + $ln1[8] = $ln2[8]; + } + } + + # Cram doesn't uppercase the reference + $ln1[9] = uc($ln1[9]); + $ln2[9] = uc($ln2[9]); + + # Cram will populate a sequence string that starts as "*" + $ln2[9] = "*" if ($ln1[9] eq "*"); + + # Fix 0<op> cigar fields + $ln1[5] =~ s/(\D|^)0\D/$1/g; + $ln1[5] =~ s/^$/*/g; + $ln2[5] =~ s/(\D|^)0\D/$1/g; + $ln2[5] =~ s/^$/*/g; + + # Fix 10M10M cigar to 20M + $ln1[5] =~ s/(\d+)(\D)(\d+)(\2)/$1+$3.$2/e; + $ln2[5] =~ s/(\d+)(\D)(\d+)(\2)/$1+$3.$2/e; + + if ("@ln1" ne "@ln2") { + print "Diff at lines $fn1:$c1, $fn2:$c2\n"; + my @s1 = split("","@ln1"); + my @s2 = split("","@ln2"); + my $ptr = ""; + for (my $i=0; $i < $#s1; $i++) { + if ($s1[$i] eq $s2[$i]) { + $ptr .= "-"; + } else { + last; + } + } + print "1\t@ln1\n2\t@ln2\n\t$ptr^\n\n"; + exit(1); + } + + $ln1 = <$fd1>; + $ln2 = <$fd2>; + + $c1++; $c2++; +} + +if (defined($ln1)) { + print "EOF on $fn1\n"; + exit(1); +} + +if (defined($ln2)) { + print "EOF on $fn2\n"; + exit(1); +} + +close($fd1); +close($fd2); + +exit(0);
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/fieldarith.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,72 @@ +/* test/fieldarith.c -- CIGAR field arithmetic test suite. + + Copyright (C) 2013 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> + +#include "htslib/sam.h" + +int ntests = 0; +int nfailures = 0; + +void check(const bam1_t *aln, const char *testname, const char *tag, int value) +{ + int32_t refvalue; + uint8_t *aux = bam_aux_get(aln, tag); + if (!aux) return; + ntests++; + refvalue = bam_aux2i(aux); + if (value != refvalue) { + fprintf(stderr, "%s FAIL for %s: computed %d != %d expected\n", + testname, bam_get_qname(aln), value, refvalue); + nfailures++; + } +} + +int main(int argc, char **argv) +{ + bam_hdr_t *header; + bam1_t *aln = bam_init1(); + int i; + + for (i = 1; i < argc; i++) { + samFile *in = sam_open(argv[i], "r"); + if (in == NULL) { perror(argv[1]); return 1; } + + header = sam_hdr_read(in); + while (sam_read1(in, header, aln) >= 0) { + check(aln, "cigar2qlen", "XQ", + bam_cigar2qlen(aln->core.n_cigar, bam_get_cigar(aln))); + check(aln, "cigar2rlen", "XR", + bam_cigar2rlen(aln->core.n_cigar, bam_get_cigar(aln))); + check(aln, "endpos", "XE", bam_endpos(aln)); + } + + bam_hdr_destroy(header); + sam_close(in); + } + + bam_destroy1(aln); + + return (nfailures > 0); +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/fieldarith.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,15 @@ +@SQ SN:one LN:1000 +@SQ SN:two LN:500 +@CO For each SAM record that has each listed aux field, performs these tests: +@CO XQ is the expected result for bam_cigar2qlen() +@CO XR is the expected result for bam_cigar2rlen() +@CO XE is the expected result for bam_endpos() +@CO (Note that these are all zero-based, while POS is one-based in SAM) +r1 0 one 50 20 8M * 0 0 ATGCATGC qqqqqqqq XQ:i:8 XR:i:8 XE:i:57 +r2 0 one 100 20 50M * 0 0 ATGCATGCATGCATGCATGCATGCATGCATGCATGCATGCATGCATGCAT qqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqq XQ:i:50 XR:i:50 XE:i:149 +unmapped 5 two 200 0 * two 200 0 ATGCATGC qqqqqqqq XQ:i:0 XR:i:0 XE:i:200 +hascigar 5 two 200 0 6M2S two 200 0 ATGCATGC qqqqqqqq XQ:i:8 XR:i:6 XE:i:200 +s1 0 one 300 20 2M * 0 0 AT qq XQ:i:2 XR:i:2 XE:i:301 +su1 4 * 0 0 * * 0 0 AT qq XQ:i:0 XR:i:0 XE:i:0 +su2 5 two 400 0 * two 400 0 AT qq XQ:i:0 XR:i:0 XE:i:400 +su3 4 one 500 0 2M * 0 0 AT qq XQ:i:2 XR:i:2 XE:i:500
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/hfile.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,204 @@ +/* test/hfile.c -- Test cases for low-level input/output streams. + + Copyright (C) 2013-2014 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdarg.h> +#include <stdio.h> +#include <stdlib.h> +#include <errno.h> + +#include <sys/stat.h> + +#include "htslib/hfile.h" +#include "htslib/hts_defs.h" + +void HTS_NORETURN fail(const char *format, ...) +{ + int err = errno; + va_list args; + va_start(args, format); + vfprintf(stderr, format, args); + va_end(args); + if (err != 0) fprintf(stderr, ": %s", strerror(err)); + fprintf(stderr, "\n"); + exit(EXIT_FAILURE); +} + +void check_offset(hFILE *f, off_t off, const char *message) +{ + off_t ret = htell(f); + if (ret < 0) fail("htell(%s)", message); + if (ret == off) return; + + fprintf(stderr, "%s offset incorrect: expected %ld but got %ld\n", + message, (long)off, (long)ret); + exit(EXIT_FAILURE); +} + +char *slurp(const char *filename) +{ + char *text; + struct stat sbuf; + size_t filesize; + FILE *f = fopen(filename, "r"); + if (f == NULL) fail("fopen(\"%s\", \"r\")", filename); + if (fstat(fileno(f), &sbuf) != 0) fail("fstat(\"%s\")", filename); + filesize = sbuf.st_size; + + text = (char *) malloc(filesize + 1); + if (text == NULL) fail("malloc(text)"); + + if (fread(text, 1, filesize, f) != filesize) fail("fread"); + fclose(f); + + text[filesize] = '\0'; + return text; +} + +hFILE *fin = NULL; +hFILE *fout = NULL; + +void reopen(const char *infname, const char *outfname) +{ + if (fin) { if (hclose(fin) != 0) fail("hclose(input)"); } + if (fout) { if (hclose(fout) != 0) fail("hclose(output)"); } + + fin = hopen(infname, "r"); + if (fin == NULL) fail("hopen(\"%s\")", infname); + + fout = hopen(outfname, "w"); + if (fout == NULL) fail("hopen(\"%s\")", outfname); +} + +int main(void) +{ + static const int size[] = { 1, 13, 403, 999, 30000 }; + + char buffer[40000]; + char *original; + int c, i; + ssize_t n; + off_t off; + + reopen("vcf.c", "test/hfile1.tmp"); + while ((c = hgetc(fin)) != EOF) { + if (hputc(c, fout) == EOF) fail("hputc"); + } + if (herrno(fin)) { errno = herrno(fin); fail("hgetc"); } + + reopen("test/hfile1.tmp", "test/hfile2.tmp"); + if (hpeek(fin, buffer, 50) < 0) fail("hpeek"); + while ((n = hread(fin, buffer, 17)) > 0) { + if (hwrite(fout, buffer, n) != n) fail("hwrite"); + } + if (n < 0) fail("hread"); + + reopen("test/hfile2.tmp", "test/hfile3.tmp"); + while ((n = hread(fin, buffer, sizeof buffer)) > 0) { + if (hwrite(fout, buffer, n) != n) fail("hwrite"); + if (hpeek(fin, buffer, 700) < 0) fail("hpeek"); + } + if (n < 0) fail("hread"); + + reopen("test/hfile3.tmp", "test/hfile4.tmp"); + i = 0; + off = 0; + while ((n = hread(fin, buffer, size[i++ % 5])) > 0) { + off += n; + buffer[n] = '\0'; + check_offset(fin, off, "pre-peek"); + if (hputs(buffer, fout) == EOF) fail("hputs"); + if ((n = hpeek(fin, buffer, size[(i+3) % 5])) < 0) fail("hpeek"); + check_offset(fin, off, "post-peek"); + } + if (n < 0) fail("hread"); + + reopen("test/hfile4.tmp", "test/hfile5.tmp"); + n = hread(fin, buffer, 200); + if (n < 0) fail("hread"); + else if (n != 200) fail("hread only got %d", (int)n); + if (hwrite(fout, buffer, 1000) != 1000) fail("hwrite"); + check_offset(fin, 200, "input/first200"); + check_offset(fout, 1000, "output/first200"); + + if (hseek(fin, 800, SEEK_CUR) < 0) fail("hseek/cur"); + check_offset(fin, 1000, "input/seek"); + for (off = 1000; (n = hread(fin, buffer, sizeof buffer)) > 0; off += n) + if (hwrite(fout, buffer, n) != n) fail("hwrite"); + if (n < 0) fail("hread"); + check_offset(fin, off, "input/eof"); + check_offset(fout, off, "output/eof"); + + if (hseek(fin, 200, SEEK_SET) < 0) fail("hseek/set"); + if (hseek(fout, 200, SEEK_SET) < 0) fail("hseek(output)"); + check_offset(fin, 200, "input/backto200"); + check_offset(fout, 200, "output/backto200"); + n = hread(fin, buffer, 800); + if (n < 0) fail("hread"); + else if (n != 800) fail("hread only got %d", (int)n); + if (hwrite(fout, buffer, 800) != 800) fail("hwrite"); + check_offset(fin, 1000, "input/wrote800"); + check_offset(fout, 1000, "output/wrote800"); + + if (hflush(fout) == EOF) fail("hflush"); + + original = slurp("vcf.c"); + for (i = 1; i <= 5; i++) { + char *text; + sprintf(buffer, "test/hfile%d.tmp", i); + text = slurp(buffer); + if (strcmp(original, text) != 0) { + fprintf(stderr, "%s differs from vcf.c\n", buffer); + return EXIT_FAILURE; + } + free(text); + } + free(original); + + if (hclose(fin) != 0) fail("hclose(input)"); + if (hclose(fout) != 0) fail("hclose(output)"); + + fout = hopen("test/hfile_chars.tmp", "w"); + if (fout == NULL) fail("hopen(\"test/hfile_chars.tmp\")"); + for (i = 0; i < 256; i++) + if (hputc(i, fout) != i) fail("chars: hputc (%d)", i); + if (hclose(fout) != 0) fail("hclose(test/hfile_chars.tmp)"); + + fin = hopen("test/hfile_chars.tmp", "r"); + if (fin == NULL) fail("hopen(\"test/hfile_chars.tmp\") for reading"); + for (i = 0; i < 256; i++) + if ((c = hgetc(fin)) != i) + fail("chars: hgetc (%d = 0x%x) returned %d = 0x%x", i, i, c, c); + if ((c = hgetc(fin)) != EOF) fail("chars: hgetc (EOF) returned %d", c); + if (hclose(fin) != 0) fail("hclose(test/hfile_chars.tmp) for reading"); + + fin = hopen("data:hello, world!\n", "r"); + if (fin == NULL) fail("hopen(\"data:...\")"); + n = hread(fin, buffer, 300); + if (n < 0) fail("hread"); + buffer[n] = '\0'; + if (strcmp(buffer, "hello, world!\n") != 0) fail("hread result"); + if (hclose(fin) != 0) fail("hclose(\"data:...\")"); + + return EXIT_SUCCESS; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/sam.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,187 @@ +/* test/sam.c -- SAM/BAM/CRAM API test cases. + + Copyright (C) 2014-2015 Genome Research Ltd. + + Author: John Marshall <jm18@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdarg.h> +#include <stdio.h> +#include <stdlib.h> +#include <string.h> +#include <math.h> + +#include "htslib/sam.h" +#include "htslib/faidx.h" +#include "htslib/kstring.h" + +int status; + +static void fail(const char *fmt, ...) +{ + va_list args; + + fprintf(stderr, "Failed: "); + va_start(args, fmt); + vfprintf(stderr, fmt, args); + va_end(args); + fprintf(stderr, "\n"); + + status = EXIT_FAILURE; +} + +uint8_t *check_bam_aux_get(const bam1_t *aln, const char *tag, char type) +{ + uint8_t *p = bam_aux_get(aln, tag); + if (p) { + if (*p == type) return p; + else fail("%s field of type '%c', expected '%c'\n", tag, *p, type); + } + else fail("can't find %s field\n", tag); + + return NULL; +} + +#define PI 3.141592653589793 +#define E 2.718281828459045 +#define HELLO "Hello, world!" +#define BEEF "DEADBEEF" + +#define str(x) #x +#define xstr(x) str(x) + +static int aux_fields1(void) +{ + static const char sam[] = "data:" +"@SQ\tSN:one\tLN:1000\n" +"@SQ\tSN:two\tLN:500\n" +"r1\t0\tone\t500\t20\t8M\t*\t0\t0\tATGCATGC\tqqqqqqqq\tXA:A:k\tXi:i:37\tXf:f:" xstr(PI) "\tXd:d:" xstr(E) "\tXZ:Z:" HELLO "\tXH:H:" BEEF "\tXB:B:c,-2,0,+2\tZZ:i:1000000\tY1:i:-2147483648\tY2:i:-2147483647\tY3:i:-1\tY4:i:0\tY5:i:1\tY6:i:2147483647\tY7:i:2147483648\tY8:i:4294967295\n"; + + // Canonical form of the alignment record above, as output by sam_format1() + static const char r1[] = "r1\t0\tone\t500\t20\t8M\t*\t0\t0\tATGCATGC\tqqqqqqqq\tXA:A:k\tXi:i:37\tXf:f:3.14159\tXd:d:2.71828\tXZ:Z:" HELLO "\tXH:H:" BEEF "\tXB:B:c,-2,0,2\tZZ:i:1000000\tY1:i:-2147483648\tY2:i:-2147483647\tY3:i:-1\tY4:i:0\tY5:i:1\tY6:i:2147483647\tY7:i:2147483648\tY8:i:4294967295"; + + samFile *in = sam_open(sam, "r"); + bam_hdr_t *header = sam_hdr_read(in); + bam1_t *aln = bam_init1(); + uint8_t *p; + uint32_t n; + kstring_t ks = { 0, 0, NULL }; + + if (sam_read1(in, header, aln) >= 0) { + if ((p = check_bam_aux_get(aln, "XA", 'A')) && bam_aux2A(p) != 'k') + fail("XA field is '%c', expected 'k'", bam_aux2A(p)); + + if ((p = check_bam_aux_get(aln, "Xi", 'C')) && bam_aux2i(p) != 37) + fail("Xi field is %d, expected 37", bam_aux2i(p)); + + if ((p = check_bam_aux_get(aln, "Xf", 'f')) && fabs(bam_aux2f(p) - PI) > 1E-6) + fail("Xf field is %.12f, expected pi", bam_aux2f(p)); + + if ((p = check_bam_aux_get(aln, "Xd", 'd')) && fabs(bam_aux2f(p) - E) > 1E-6) + fail("Xf field is %.12f, expected e", bam_aux2f(p)); + + if ((p = check_bam_aux_get(aln, "XZ", 'Z')) && strcmp(bam_aux2Z(p), HELLO) != 0) + fail("XZ field is \"%s\", expected \"%s\"", bam_aux2Z(p), HELLO); + + if ((p = check_bam_aux_get(aln, "XH", 'H')) && strcmp(bam_aux2Z(p), BEEF) != 0) + fail("XH field is \"%s\", expected \"%s\"", bam_aux2Z(p), BEEF); + + // TODO Invent and use bam_aux2B() + if ((p = check_bam_aux_get(aln, "XB", 'B')) && ! (memcmp(p, "Bc", 2) == 0 && (memcpy(&n, p+2, 4), n) == 3 && memcmp(p+6, "\xfe\x00\x02", 3) == 0)) + fail("XB field is %c,..., expected c,-2,0,+2", p[1]); + + if ((p = check_bam_aux_get(aln, "ZZ", 'I')) && bam_aux2i(p) != 1000000) + fail("ZZ field is %d, expected 1000000", bam_aux2i(p)); + + if ((p = bam_aux_get(aln, "Y1")) && bam_aux2i(p) != -2147483647-1) + fail("Y1 field is %d, expected -2^31", bam_aux2i(p)); + + if ((p = bam_aux_get(aln, "Y2")) && bam_aux2i(p) != -2147483647) + fail("Y2 field is %d, expected -2^31+1", bam_aux2i(p)); + + if ((p = bam_aux_get(aln, "Y3")) && bam_aux2i(p) != -1) + fail("Y3 field is %d, expected -1", bam_aux2i(p)); + + if ((p = bam_aux_get(aln, "Y4")) && bam_aux2i(p) != 0) + fail("Y4 field is %d, expected 0", bam_aux2i(p)); + + if ((p = bam_aux_get(aln, "Y5")) && bam_aux2i(p) != 1) + fail("Y5 field is %d, expected 1", bam_aux2i(p)); + + if ((p = bam_aux_get(aln, "Y6")) && bam_aux2i(p) != 2147483647) + fail("Y6 field is %d, expected 2^31-1", bam_aux2i(p)); + + // TODO Checking these perhaps requires inventing bam_aux2u() or so +#if 0 + if ((p = bam_aux_get(aln, "Y7")) && bam_aux2i(p) != 2147483648) + fail("Y7 field is %d, expected 2^31", bam_aux2i(p)); + + if ((p = bam_aux_get(aln, "Y8")) && bam_aux2i(p) != 4294967295) + fail("Y8 field is %d, expected 2^32-1", bam_aux2i(p)); +#endif + + if (sam_format1(header, aln, &ks) < 0) + fail("can't format record"); + + if (strcmp(ks.s, r1) != 0) + fail("record formatted incorrectly: \"%s\"", ks.s); + + free(ks.s); + } + else fail("can't read record"); + + bam_destroy1(aln); + bam_hdr_destroy(header); + sam_close(in); + + return 1; +} + +static void iterators1(void) +{ + hts_itr_destroy(sam_itr_queryi(NULL, HTS_IDX_REST, 0, 0)); + hts_itr_destroy(sam_itr_queryi(NULL, HTS_IDX_NONE, 0, 0)); +} + +static void faidx1(const char *filename) +{ + int n; + faidx_t *fai = fai_load(filename); + if (fai == NULL) fail("can't load faidx file"); + + n = faidx_fetch_nseq(fai); + if (n != 7) fail("faidx_fetch_nseq returned %d, expected 7", n); + + n = faidx_nseq(fai); + if (n != 7) fail("faidx_nseq returned %d, expected 7", n); + + fai_destroy(fai); +} + +int main(int argc, char **argv) +{ + status = EXIT_SUCCESS; + + aux_fields1(); + iterators1(); + if (argc >= 2) faidx1(argv[1]); + + return status; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test-regidx.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,116 @@ +/* test/test-regidx.c -- Regions index test harness. + + Copyright (C) 2014 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + + Permission is hereby granted, free of charge, to any person obtaining a copy + of this software and associated documentation files (the "Software"), to deal + in the Software without restriction, including without limitation the rights + to use, copy, modify, merge, publish, distribute, sublicense, and/or sell + copies of the Software, and to permit persons to whom the Software is + furnished to do so, subject to the following conditions: + + The above copyright notice and this permission notice shall be included in + all copies or substantial portions of the Software. + + THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR + IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, + FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE + AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER + LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, + OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN + THE SOFTWARE. +*/ + +#include <stdarg.h> +#include <stdlib.h> +#include <stdio.h> +#include <ctype.h> +#include <string.h> +#include <htslib/regidx.h> + +void error(const char *format, ...) +{ + va_list ap; + va_start(ap, format); + vfprintf(stderr, format, ap); + va_end(ap); + exit(-1); +} + +int custom_parse(const char *line, char **chr_beg, char **chr_end, reg_t *reg, void *payload, void *usr) +{ + // Use the standard parser for CHROM,FROM,TO + int i, ret = regidx_parse_tab(line,chr_beg,chr_end,reg,NULL,NULL); + if ( ret!=0 ) return ret; + + // Skip the fields that were parsed above + char *ss = (char*) line; + while ( *ss && isspace(*ss) ) ss++; + for (i=0; i<3; i++) + { + while ( *ss && !isspace(*ss) ) ss++; + if ( !*ss ) return -2; // wrong number of fields + while ( *ss && isspace(*ss) ) ss++; + } + if ( !*ss ) return -2; + + // Parse the payload + char *se = ss; + while ( *se && !isspace(*se) ) se++; + char **dat = (char**) payload; + *dat = (char*) malloc(se-ss+1); + memcpy(*dat,ss,se-ss+1); + (*dat)[se-ss] = 0; + return 0; +} +void custom_free(void *payload) +{ + char **dat = (char**)payload; + free(*dat); +} + +int main(int argc, char **argv) +{ + // Init index with no file name, we will insert the regions manually + regidx_t *idx = regidx_init(NULL,custom_parse,custom_free,sizeof(char*),NULL); + if ( !idx ) error("init failed\n"); + + // Insert regions + char *line; + line = "1 10000000 10000000 1:10000000-10000000"; if ( regidx_insert(idx,line)!=0 ) error("insert failed: %s\n", line); + line = "1 20000000 20000001 1:20000000-20000001"; if ( regidx_insert(idx,line)!=0 ) error("insert failed: %s\n", line); + line = "1 20000002 20000002 1:20000002-20000002"; if ( regidx_insert(idx,line)!=0 ) error("insert failed: %s\n", line); + line = "1 30000000 30000000 1:30000000-30000000"; if ( regidx_insert(idx,line)!=0 ) error("insert failed: %s\n", line); + + // Finish initialization + regidx_insert(idx,NULL); + + // Test + regitr_t itr; + int from, to; + + from = to = 10000000; + if ( !regidx_overlap(idx,"1",from-1,to-1,&itr) ) error("query failed: 1:%d-%d\n",from,to); + if ( strcmp("1:10000000-10000000",REGITR_PAYLOAD(itr,char*)) ) error("query failed: 1:%d-%d vs %s\n", from,to,REGITR_PAYLOAD(itr,char*)); + if ( !regidx_overlap(idx,"1",from-2,to-1,&itr) ) error("query failed: 1:%d-%d\n",from-1,to); + if ( !regidx_overlap(idx,"1",from-2,to+3,&itr) ) error("query failed: 1:%d-%d\n",from-1,to+2); + if ( regidx_overlap(idx,"1",from-2,to-2,&itr) ) error("query failed: 1:%d-%d\n",from-1,to-1); + + from = to = 20000000; + if ( !regidx_overlap(idx,"1",from-1,to-1,&itr) ) error("query failed: 1:%d-%d\n",from,to); + + from = to = 20000002; + if ( !regidx_overlap(idx,"1",from-1,to-1,&itr) ) error("query failed: 1:%d-%d\n",from,to); + + from = to = 30000000; + if ( !regidx_overlap(idx,"1",from-1,to-1,&itr) ) error("query failed: 1:%d-%d\n",from,to); + + // Clean up + regidx_destroy(idx); + + return 0; +} + +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test-vcf-api.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,282 @@ +/* test/test-vcf-api.c -- VCF test harness. + + Copyright (C) 2013, 2014 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> +#include <htslib/hts.h> +#include <htslib/vcf.h> +#include <htslib/kstring.h> +#include <htslib/kseq.h> + +void write_bcf(char *fname) +{ + // Init + htsFile *fp = hts_open(fname,"wb"); + bcf_hdr_t *hdr = bcf_hdr_init("w"); + bcf1_t *rec = bcf_init1(); + + // Create VCF header + kstring_t str = {0,0,0}; + bcf_hdr_append(hdr, "##fileDate=20090805"); + bcf_hdr_append(hdr, "##FORMAT=<ID=UF,Number=1,Type=Integer,Description=\"Unused FORMAT\">"); + bcf_hdr_append(hdr, "##INFO=<ID=UI,Number=1,Type=Integer,Description=\"Unused INFO\">"); + bcf_hdr_append(hdr, "##FILTER=<ID=Flt,Description=\"Unused FILTER\">"); + bcf_hdr_append(hdr, "##unused=<XX=AA,Description=\"Unused generic\">"); + bcf_hdr_append(hdr, "##unused=unformatted text 1"); + bcf_hdr_append(hdr, "##unused=unformatted text 2"); + bcf_hdr_append(hdr, "##contig=<ID=Unused,length=62435964>"); + bcf_hdr_append(hdr, "##source=myImputationProgramV3.1"); + bcf_hdr_append(hdr, "##reference=file:///seq/references/1000GenomesPilot-NCBI36.fasta"); + bcf_hdr_append(hdr, "##contig=<ID=20,length=62435964,assembly=B36,md5=f126cdf8a6e0c7f379d618ff66beb2da,species=\"Homo sapiens\",taxonomy=x>"); + bcf_hdr_append(hdr, "##phasing=partial"); + bcf_hdr_append(hdr, "##INFO=<ID=NS,Number=1,Type=Integer,Description=\"Number of Samples With Data\">"); + bcf_hdr_append(hdr, "##INFO=<ID=DP,Number=1,Type=Integer,Description=\"Total Depth\">"); + bcf_hdr_append(hdr, "##INFO=<ID=AF,Number=A,Type=Float,Description=\"Allele Frequency\">"); + bcf_hdr_append(hdr, "##INFO=<ID=AA,Number=1,Type=String,Description=\"Ancestral Allele\">"); + bcf_hdr_append(hdr, "##INFO=<ID=DB,Number=0,Type=Flag,Description=\"dbSNP membership, build 129\">"); + bcf_hdr_append(hdr, "##INFO=<ID=H2,Number=0,Type=Flag,Description=\"HapMap2 membership\">"); + bcf_hdr_append(hdr, "##FILTER=<ID=q10,Description=\"Quality below 10\">"); + bcf_hdr_append(hdr, "##FILTER=<ID=s50,Description=\"Less than 50% of samples have data\">"); + bcf_hdr_append(hdr, "##FORMAT=<ID=GT,Number=1,Type=String,Description=\"Genotype\">"); + bcf_hdr_append(hdr, "##FORMAT=<ID=GQ,Number=1,Type=Integer,Description=\"Genotype Quality\">"); + bcf_hdr_append(hdr, "##FORMAT=<ID=DP,Number=1,Type=Integer,Description=\"Read Depth\">"); + bcf_hdr_append(hdr, "##FORMAT=<ID=HQ,Number=2,Type=Integer,Description=\"Haplotype Quality\">"); + bcf_hdr_append(hdr, "##FORMAT=<ID=TS,Number=1,Type=String,Description=\"Test String\">"); + + bcf_hdr_add_sample(hdr, "NA00001"); + bcf_hdr_add_sample(hdr, "NA00002"); + bcf_hdr_add_sample(hdr, "NA00003"); + bcf_hdr_add_sample(hdr, NULL); // to update internal structures + bcf_hdr_write(fp, hdr); + + + // Add a record + // 20 14370 rs6054257 G A 29 PASS NS=3;DP=14;AF=0.5;DB;H2 GT:GQ:DP:HQ 0|0:48:1:51,51 1|0:48:8:51,51 1/1:43:5:.,. + // .. CHROM + rec->rid = bcf_hdr_name2id(hdr, "20"); + // .. POS + rec->pos = 14369; + // .. ID + bcf_update_id(hdr, rec, "rs6054257"); + // .. REF and ALT + bcf_update_alleles_str(hdr, rec, "G,A"); + // .. QUAL + rec->qual = 29; + // .. FILTER + int32_t tmpi = bcf_hdr_id2int(hdr, BCF_DT_ID, "PASS"); + bcf_update_filter(hdr, rec, &tmpi, 1); + // .. INFO + tmpi = 3; + bcf_update_info_int32(hdr, rec, "NS", &tmpi, 1); + tmpi = 14; + bcf_update_info_int32(hdr, rec, "DP", &tmpi, 1); + float tmpf = 0.5; + bcf_update_info_float(hdr, rec, "AF", &tmpf, 1); + bcf_update_info_flag(hdr, rec, "DB", NULL, 1); + bcf_update_info_flag(hdr, rec, "H2", NULL, 1); + // .. FORMAT + int32_t *tmpia = (int*)malloc(bcf_hdr_nsamples(hdr)*2*sizeof(int)); + tmpia[0] = bcf_gt_phased(0); + tmpia[1] = bcf_gt_phased(0); + tmpia[2] = bcf_gt_phased(1); + tmpia[3] = bcf_gt_phased(0); + tmpia[4] = bcf_gt_unphased(1); + tmpia[5] = bcf_gt_unphased(1); + bcf_update_genotypes(hdr, rec, tmpia, bcf_hdr_nsamples(hdr)*2); + tmpia[0] = 48; + tmpia[1] = 48; + tmpia[2] = 43; + bcf_update_format_int32(hdr, rec, "GQ", tmpia, bcf_hdr_nsamples(hdr)); + tmpia[0] = 1; + tmpia[1] = 8; + tmpia[2] = 5; + bcf_update_format_int32(hdr, rec, "DP", tmpia, bcf_hdr_nsamples(hdr)); + tmpia[0] = 51; + tmpia[1] = 51; + tmpia[2] = 51; + tmpia[3] = 51; + tmpia[4] = bcf_int32_missing; + tmpia[5] = bcf_int32_missing; + bcf_update_format_int32(hdr, rec, "HQ", tmpia, bcf_hdr_nsamples(hdr)*2); + char *tmp_str[] = {"String1","SomeOtherString2","YetAnotherString3"}; + bcf_update_format_string(hdr, rec, "TS", (const char**)tmp_str, 3); + bcf_write1(fp, hdr, rec); + + // 20 1110696 . A G,T 67 . NS=2;DP=10;AF=0.333,.;AA=T;DB GT 2 1 ./. + bcf_clear1(rec); + rec->rid = bcf_hdr_name2id(hdr, "20"); + rec->pos = 1110695; + bcf_update_alleles_str(hdr, rec, "A,G,T"); + rec->qual = 67; + tmpi = 2; + bcf_update_info_int32(hdr, rec, "NS", &tmpi, 1); + tmpi = 10; + bcf_update_info_int32(hdr, rec, "DP", &tmpi, 1); + float *tmpfa = (float*)malloc(2*sizeof(float)); + tmpfa[0] = 0.333; + bcf_float_set_missing(tmpfa[1]); + bcf_update_info_float(hdr, rec, "AF", tmpfa, 2); + bcf_update_info_string(hdr, rec, "AA", "T"); + bcf_update_info_flag(hdr, rec, "DB", NULL, 1); + tmpia[0] = bcf_gt_phased(2); + tmpia[1] = bcf_int32_vector_end; + tmpia[2] = bcf_gt_phased(1); + tmpia[3] = bcf_int32_vector_end; + tmpia[4] = bcf_gt_missing; + tmpia[5] = bcf_gt_missing; + bcf_update_genotypes(hdr, rec, tmpia, bcf_hdr_nsamples(hdr)*2); + bcf_write1(fp, hdr, rec); + + free(tmpia); + free(tmpfa); + + // Clean + free(str.s); + bcf_destroy1(rec); + bcf_hdr_destroy(hdr); + int ret; + if ( (ret=hts_close(fp)) ) + { + fprintf(stderr,"hts_close(%s): non-zero status %d\n",fname,ret); + exit(ret); + } +} + +void bcf_to_vcf(char *fname) +{ + htsFile *fp = hts_open(fname,"rb"); + bcf_hdr_t *hdr = bcf_hdr_read(fp); + bcf1_t *rec = bcf_init1(); + + char *gz_fname = (char*) malloc(strlen(fname)+4); + snprintf(gz_fname,strlen(fname)+4,"%s.gz",fname); + htsFile *out = hts_open(gz_fname,"wg"); + + bcf_hdr_t *hdr_out = bcf_hdr_dup(hdr); + bcf_hdr_remove(hdr_out,BCF_HL_STR,"unused"); + bcf_hdr_remove(hdr_out,BCF_HL_GEN,"unused"); + bcf_hdr_remove(hdr_out,BCF_HL_FLT,"Flt"); + bcf_hdr_remove(hdr_out,BCF_HL_INFO,"UI"); + bcf_hdr_remove(hdr_out,BCF_HL_FMT,"UF"); + bcf_hdr_remove(hdr_out,BCF_HL_CTG,"Unused"); + bcf_hdr_write(out, hdr_out); + + while ( bcf_read1(fp, hdr, rec)>=0 ) + { + bcf_write1(out, hdr_out, rec); + + // Test problems caused by bcf1_sync: the data block + // may be realloced, also the unpacked structures must + // get updated. + bcf_unpack(rec, BCF_UN_STR); + bcf_update_id(hdr, rec, 0); + bcf_update_format_int32(hdr, rec, "GQ", NULL, 0); + + bcf1_t *dup = bcf_dup(rec); // force bcf1_sync call + bcf_write1(out, hdr_out, dup); + bcf_destroy1(dup); + + bcf_update_alleles_str(hdr_out, rec, "G,A"); + int32_t tmpi = 99; + bcf_update_info_int32(hdr_out, rec, "DP", &tmpi, 1); + int32_t tmpia[] = {9,9,9}; + bcf_update_format_int32(hdr_out, rec, "DP", tmpia, 3); + + bcf_write1(out, hdr_out, rec); + } + + bcf_destroy1(rec); + bcf_hdr_destroy(hdr); + bcf_hdr_destroy(hdr_out); + int ret; + if ( (ret=hts_close(fp)) ) + { + fprintf(stderr,"hts_close(%s): non-zero status %d\n",fname,ret); + exit(ret); + } + if ( (ret=hts_close(out)) ) + { + fprintf(stderr,"hts_close(%s): non-zero status %d\n",gz_fname,ret); + exit(ret); + } + + + // read gzip, write stdout + htsFile *gz_in = hts_open(gz_fname, "r"); + if ( !gz_in ) + { + fprintf(stderr,"Could not read: %s\n", gz_fname); + exit(1); + } + + kstring_t line = {0,0,0}; + while ( hts_getline(gz_in, KS_SEP_LINE, &line)>0 ) + { + kputc('\n',&line); + fwrite(line.s,1,line.l,stdout); + } + + if ( (ret=hts_close(gz_in)) ) + { + fprintf(stderr,"hts_close(%s): non-zero status %d\n",gz_fname,ret); + exit(ret); + } + free(line.s); + free(gz_fname); +} + +void iterator(const char *fname) +{ + htsFile *fp = hts_open(fname, "r"); + bcf_hdr_t *hdr = bcf_hdr_read(fp); + hts_idx_t *idx; + hts_itr_t *iter; + + bcf_index_build(fname, 0); + idx = bcf_index_load(fname); + + iter = bcf_itr_queryi(idx, bcf_hdr_name2id(hdr, "20"), 1110600, 1110800); + bcf_itr_destroy(iter); + + iter = bcf_itr_querys(idx, hdr, "20:1110600-1110800"); + bcf_itr_destroy(iter); + + hts_idx_destroy(idx); + bcf_hdr_destroy(hdr); + int ret; + if ( (ret=hts_close(fp)) ) + { + fprintf(stderr,"hts_close(%s): non-zero status %d\n",fname,ret); + exit(ret); + } +} + +int main(int argc, char **argv) +{ + char *fname = argc>1 ? argv[1] : "rmme.bcf"; + write_bcf(fname); + bcf_to_vcf(fname); + iterator(fname); + return 0; +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test-vcf-api.out Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,28 @@ +##fileformat=VCFv4.2 +##FILTER=<ID=PASS,Description="All filters passed"> +##fileDate=20090805 +##unused=<XX=AA,Description="Unused generic"> +##source=myImputationProgramV3.1 +##reference=file:///seq/references/1000GenomesPilot-NCBI36.fasta +##contig=<ID=20,length=62435964,assembly=B36,md5=f126cdf8a6e0c7f379d618ff66beb2da,species="Homo sapiens",taxonomy=x> +##phasing=partial +##INFO=<ID=NS,Number=1,Type=Integer,Description="Number of Samples With Data"> +##INFO=<ID=DP,Number=1,Type=Integer,Description="Total Depth"> +##INFO=<ID=AF,Number=A,Type=Float,Description="Allele Frequency"> +##INFO=<ID=AA,Number=1,Type=String,Description="Ancestral Allele"> +##INFO=<ID=DB,Number=0,Type=Flag,Description="dbSNP membership, build 129"> +##INFO=<ID=H2,Number=0,Type=Flag,Description="HapMap2 membership"> +##FILTER=<ID=q10,Description="Quality below 10"> +##FILTER=<ID=s50,Description="Less than 50% of samples have data"> +##FORMAT=<ID=GT,Number=1,Type=String,Description="Genotype"> +##FORMAT=<ID=GQ,Number=1,Type=Integer,Description="Genotype Quality"> +##FORMAT=<ID=DP,Number=1,Type=Integer,Description="Read Depth"> +##FORMAT=<ID=HQ,Number=2,Type=Integer,Description="Haplotype Quality"> +##FORMAT=<ID=TS,Number=1,Type=String,Description="Test String"> +#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT NA00001 NA00002 NA00003 +20 14370 rs6054257 G A 29 PASS NS=3;DP=14;AF=0.5;DB;H2 GT:GQ:DP:HQ:TS 0|0:48:1:51,51:String1 1|0:48:8:51,51:SomeOtherString2 1/1:43:5:.,.:YetAnotherString3 +20 14370 . G A 29 PASS NS=3;DP=14;AF=0.5;DB;H2 GT:DP:HQ:TS 0|0:1:51,51:String1 1|0:8:51,51:SomeOtherString2 1/1:5:.,.:YetAnotherString3 +20 14370 . G A 29 PASS NS=3;DP=99;AF=0.5;DB;H2 GT:DP:HQ:TS 0|0:9:51,51:String1 1|0:9:51,51:SomeOtherString2 1/1:9:.,.:YetAnotherString3 +20 1110696 . A G,T 67 . NS=2;DP=10;AF=0.333,.;AA=T;DB GT 2 1 ./. +20 1110696 . A G,T 67 . NS=2;DP=10;AF=0.333,.;AA=T;DB GT 2 1 ./. +20 1110696 . G A 67 . NS=2;DP=99;AF=0.333,.;AA=T;DB GT:DP 2:9 1:9 ./.:9
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test-vcf-sweep.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,112 @@ +/* test/test-vcf-sweep.c -- VCF test harness. + + Copyright (C) 2013 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> +#include <htslib/vcf_sweep.h> + +int main(int argc, char **argv) +{ + if ( argc!=2 ) + { + fprintf(stderr,"Usage: test-vcf-sweep <file.bcf|file.vcf>\n"); + return 1; + } + + // Init variables. The checksum is just for this test program to output + // something and verify that all sites are read in both passes - fwd and + // bwd. + bcf_sweep_t *sw = bcf_sweep_init(argv[1]); + bcf_hdr_t *hdr = bcf_sweep_hdr(sw); + int chksum = 0; + + // First we must sweep forward and read the whole file to build an index. + // If this is undesirable, we can require the presence of a .gzi index + // which can be created with `bgzip -r` from the samtools/htslib package + bcf1_t *rec; + while ( (rec = bcf_sweep_fwd(sw)) ) chksum += rec->pos+1; + printf("fwd position chksum: %d\n", chksum); + + // Now sweep backward. + chksum = 0; + while ( (rec = bcf_sweep_bwd(sw)) ) chksum += rec->pos+1; + printf("bwd position chksum: %d\n", chksum); + + // And forward and backward again, this time summing the PL vectors + int i,j, mPLs = 0, nPLs; + int32_t *PLs = NULL; + chksum = 0; + while ( (rec = bcf_sweep_fwd(sw)) ) + { + // get copy of the PL vectors + nPLs = bcf_get_format_int32(hdr, rec, "PL", &PLs, &mPLs); + if ( !nPLs ) continue; // PL not present + + // how many values are there per sample + int nvals = nPLs / bcf_hdr_nsamples(hdr); + + int32_t *ptr = PLs; + for (i=0; i<bcf_hdr_nsamples(hdr); i++) + { + for (j=0; j<nvals; j++) + { + // check for shorter vectors (haploid genotypes amongst diploids) + if ( ptr[j]==bcf_int32_vector_end ) break; + + // skip missing values + if ( ptr[j]==bcf_int32_missing ) continue; + + chksum += ptr[j]; + } + ptr += nvals; + } + } + printf("fwd PL chksum: %d\n", chksum); + + // And the same backwards.. + chksum = 0; + while ( (rec = bcf_sweep_bwd(sw)) ) + { + nPLs = bcf_get_format_int32(hdr, rec, "PL", &PLs, &mPLs); + if ( !nPLs ) continue; + int nvals = nPLs / bcf_hdr_nsamples(hdr); + int32_t *ptr = PLs; + for (i=0; i<bcf_hdr_nsamples(hdr); i++) + { + for (j=0; j<nvals; j++) + { + if ( ptr[j]==bcf_int32_vector_end ) break; + if ( ptr[j]==bcf_int32_missing ) continue; + chksum += ptr[j]; + } + ptr += nvals; + } + } + printf("bwd PL chksum: %d\n", chksum); + + // Clean up + bcf_sweep_destroy(sw); + return 0; +} + +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test-vcf-sweep.out Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,4 @@ +fwd position chksum: 1125066 +bwd position chksum: 1125066 +fwd PL chksum: 0 +bwd PL chksum: 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test.pl Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,202 @@ +#!/usr/bin/env perl +# +# Copyright (C) 2012-2013 Genome Research Ltd. +# +# Author: Petr Danecek <pd3@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. + +use strict; +use warnings; +use Carp; +use FindBin; +use lib "$FindBin::Bin"; +use Getopt::Long; +use File::Temp qw/ tempfile tempdir /; + +my $opts = parse_params(); + +test_vcf_api($opts,out=>'test-vcf-api.out'); +test_vcf_sweep($opts,out=>'test-vcf-sweep.out'); + +print "\nNumber of tests:\n"; +printf " total .. %d\n", $$opts{nok}+$$opts{nfailed}; +printf " passed .. %d\n", $$opts{nok}; +printf " failed .. %d\n", $$opts{nfailed}; +print "\n"; + +exit ($$opts{nfailed} > 0); + +#-------------------- + +sub error +{ + my (@msg) = @_; + if ( scalar @msg ) { confess @msg; } + print + "About: samtools/htslib consistency test script\n", + "Usage: test.pl [OPTIONS]\n", + "Options:\n", + " -r, --redo-outputs Recreate expected output files.\n", + " -t, --temp-dir <path> When given, temporary files will not be removed.\n", + " -h, -?, --help This help message.\n", + "\n"; + exit 1; +} +sub parse_params +{ + my $opts = { keep_files=>0, nok=>0, nfailed=>0 }; + my $help; + Getopt::Long::Configure('bundling'); + my $ret = GetOptions ( + 't|temp-dir:s' => \$$opts{keep_files}, + 'r|redo-outputs' => \$$opts{redo_outputs}, + 'h|?|help' => \$help + ); + if ( !$ret or $help ) { error(); } + $$opts{tmp} = $$opts{keep_files} ? $$opts{keep_files} : tempdir(CLEANUP=>1); + if ( $$opts{keep_files} ) { cmd("mkdir -p $$opts{keep_files}"); } + $$opts{path} = $FindBin::RealBin; + $$opts{bin} = $FindBin::RealBin; + $$opts{bin} =~ s{/test/?$}{}; + return $opts; +} +sub _cmd +{ + my ($cmd) = @_; + my $kid_io; + my @out; + my $pid = open($kid_io, "-|"); + if ( !defined $pid ) { error("Cannot fork: $!"); } + if ($pid) + { + # parent + @out = <$kid_io>; + close($kid_io); + } + else + { + # child + exec('/bin/bash', '-o','pipefail','-c', $cmd) or error("Cannot execute the command [/bin/sh -o pipefail -c $cmd]: $!"); + } + return ($? >> 8, join('',@out)); +} +sub cmd +{ + my ($cmd) = @_; + my ($ret,$out) = _cmd($cmd); + if ( $ret ) { error("The command failed [$ret]: $cmd\n", $out); } + return $out; +} +sub test_cmd +{ + my ($opts,%args) = @_; + if ( !exists($args{out}) ) + { + if ( !exists($args{in}) ) { error("FIXME: expected out or in key\n"); } + $args{out} = "$args{in}.out"; + } + my ($package, $filename, $line, $test)=caller(1); + $test =~ s/^.+:://; + + print "$test:\n"; + print "\t$args{cmd}\n"; + + my ($ret,$out) = _cmd("$args{cmd} 2>&1"); + if ( $ret ) { failed($opts,$test); return; } + if ( $$opts{redo_outputs} && -e "$$opts{path}/$args{out}" ) + { + rename("$$opts{path}/$args{out}","$$opts{path}/$args{out}.old"); + open(my $fh,'>',"$$opts{path}/$args{out}") or error("$$opts{path}/$args{out}: $!"); + print $fh $out; + close($fh); + my ($ret,$out) = _cmd("diff -q $$opts{path}/$args{out} $$opts{path}/$args{out}.old"); + if ( !$ret && $out eq '' ) { unlink("$$opts{path}/$args{out}.old"); } + else + { + print "\tthe expected output changed, saving:\n"; + print "\t old .. $$opts{path}/$args{out}.old\n"; + print "\t new .. $$opts{path}/$args{out}\n"; + } + } + my $exp = ''; + if ( open(my $fh,'<',"$$opts{path}/$args{out}") ) + { + my @exp = <$fh>; + $exp = join('',@exp); + close($fh); + } + elsif ( !$$opts{redo_outputs} ) { failed($opts,$test,"$$opts{path}/$args{out}: $!"); return; } + + if ( $exp ne $out ) + { + open(my $fh,'>',"$$opts{path}/$args{out}.new") or error("$$opts{path}/$args{out}.new"); + print $fh $out; + close($fh); + if ( !-e "$$opts{path}/$args{out}" ) + { + rename("$$opts{path}/$args{out}.new","$$opts{path}/$args{out}") or error("rename $$opts{path}/$args{out}.new $$opts{path}/$args{out}: $!"); + print "\tthe file with expected output does not exist, creating new one:\n"; + print "\t\t$$opts{path}/$args{out}\n"; + } + else + { + failed($opts,$test,"The outputs differ:\n\t\t$$opts{path}/$args{out}\n\t\t$$opts{path}/$args{out}.new"); + } + return; + } + passed($opts,$test); +} +sub failed +{ + my ($opts,$test,$reason) = @_; + $$opts{nfailed}++; + if ( defined $reason ) { print "\n\t$reason"; } + print "\n.. failed ...\n\n"; +} +sub passed +{ + my ($opts,$test) = @_; + $$opts{nok}++; + print ".. ok\n\n"; +} +sub is_file_newer +{ + my ($afile,$bfile) = @_; + my (@astat) = stat($afile) or return 0; + my (@bstat) = stat($bfile) or return 0; + if ( $astat[9]>$bstat[9] ) { return 1 } + return 0; +} + + +# The tests -------------------------- + +sub test_vcf_api +{ + my ($opts,%args) = @_; + test_cmd($opts,%args,cmd=>"$$opts{path}/test-vcf-api $$opts{tmp}/test-vcf-api.bcf"); +} + +sub test_vcf_sweep +{ + my ($opts,%args) = @_; + test_cmd($opts,%args,cmd=>"$$opts{path}/test-vcf-sweep $$opts{tmp}/test-vcf-api.bcf"); +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test_view.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,239 @@ +/* test/test_view.c -- simple view tool, purely for use in a test harness. + + Copyright (C) 2012 Broad Institute. + Copyright (C) 2013-2014 Genome Research Ltd. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <stdio.h> +#include <unistd.h> +#include <stdlib.h> +#include <string.h> + +#include "cram/cram.h" + +#include "htslib/sam.h" + +typedef struct hts_opt { + enum cram_option opt; + union { + int i; + char *s; + } val; + struct hts_opt *next; +} hts_opt; + +/* + * Parses arg and appends it to the option list. + * Returns 0 on success; + * -1 on failure. + */ +int add_option(hts_opt **opts, char *arg) { + hts_opt *o, *t; + char *cp; + + if (!(cp = strchr(arg, '='))) + cp = "1"; // assume boolean + else + *cp++ = 0; + + if (!(o = malloc(sizeof(*o)))) + return -1; + + if (strcmp(arg, "DECODE_MD") == 0) + o->opt = CRAM_OPT_DECODE_MD, o->val.i = atoi(cp); + else if (strcmp(arg, "VERBOSITY") == 0) + o->opt = CRAM_OPT_VERBOSITY, o->val.i = atoi(cp); + else if (strcmp(arg, "SEQS_PER_SLICE") == 0) + o->opt = CRAM_OPT_SEQS_PER_SLICE, o->val.i = atoi(cp); + else if (strcmp(arg, "SLICES_PER_CONTAINER") == 0) + o->opt = CRAM_OPT_SLICES_PER_CONTAINER, o->val.i = atoi(cp); + else if (strcmp(arg, "EMBED_REF") == 0) + o->opt = CRAM_OPT_EMBED_REF, o->val.i = atoi(cp); + else if (strcmp(arg, "NO_REF") == 0) + o->opt = CRAM_OPT_NO_REF, o->val.i = atoi(cp); + else if (strcmp(arg, "IGNORE_MD5") == 0) + o->opt = CRAM_OPT_IGNORE_MD5, o->val.i = atoi(cp); + else if (strcmp(arg, "USE_BZIP2") == 0) + o->opt = CRAM_OPT_USE_BZIP2, o->val.i = atoi(cp); + else if (strcmp(arg, "USE_RANS") == 0) + o->opt = CRAM_OPT_USE_RANS, o->val.i = atoi(cp); + else if (strcmp(arg, "USE_LZMA") == 0) + o->opt = CRAM_OPT_USE_LZMA, o->val.i = atoi(cp); + else if (strcmp(arg, "REFERENCE") == 0) + o->opt = CRAM_OPT_REFERENCE, o->val.s = cp; + else if (strcmp(arg, "VERSION") == 0) + o->opt = CRAM_OPT_VERSION, o->val.s =cp; + else if (strcmp(arg, "MULTI_SEQ_PER_SLICE") == 0) + o->opt = CRAM_OPT_MULTI_SEQ_PER_SLICE, o->val.i = atoi(cp); + else if (strcmp(arg, "NTHREADS") == 0) + o->opt = CRAM_OPT_NTHREADS, o->val.i = atoi(cp); + else if (strcmp(arg, "REQUIRED_FIELDS") == 0) + o->opt = CRAM_OPT_REQUIRED_FIELDS, o->val.i = strtol(cp, NULL, 0); + else { + fprintf(stderr, "Unknown option '%s'\n", arg); + free(o); + return -1; + } + + o->next = NULL; + + if (*opts) { + t = *opts; + while (t->next) + t = t->next; + t->next = o; + } else { + *opts = o; + } + + return 0; +} + +int main(int argc, char *argv[]) +{ + samFile *in; + char *fn_ref = 0; + int flag = 0, c, clevel = -1, ignore_sam_err = 0; + char moder[8]; + bam_hdr_t *h; + bam1_t *b; + htsFile *out; + char modew[8]; + int r = 0, exit_code = 0; + hts_opt *in_opts = NULL, *out_opts = NULL, *last = NULL; + + while ((c = getopt(argc, argv, "IbDCSl:t:i:o:")) >= 0) { + switch (c) { + case 'S': flag |= 1; break; + case 'b': flag |= 2; break; + case 'D': flag |= 4; break; + case 'C': flag |= 8; break; + case 'l': clevel = atoi(optarg); flag |= 2; break; + case 't': fn_ref = optarg; break; + case 'I': ignore_sam_err = 1; break; + case 'i': if (add_option(&in_opts, optarg)) return 1; break; + case 'o': if (add_option(&out_opts, optarg)) return 1; break; + } + } + if (argc == optind) { + fprintf(stderr, "Usage: samview [-bSCSI] [-l level] [-o option=value] <in.bam>|<in.sam>|<in.cram> [region]\n"); + return 1; + } + strcpy(moder, "r"); + if (flag&4) strcat(moder, "c"); + else if ((flag&1) == 0) strcat(moder, "b"); + + in = sam_open(argv[optind], moder); + if (in == NULL) { + fprintf(stderr, "Error opening \"%s\"\n", argv[optind]); + return EXIT_FAILURE; + } + h = sam_hdr_read(in); + h->ignore_sam_err = ignore_sam_err; + b = bam_init1(); + + strcpy(modew, "w"); + if (clevel >= 0 && clevel <= 9) sprintf(modew + 1, "%d", clevel); + if (flag&8) strcat(modew, "c"); + else if (flag&2) strcat(modew, "b"); + out = hts_open("-", modew); + if (out == NULL) { + fprintf(stderr, "Error opening standard output\n"); + return EXIT_FAILURE; + } + + /* CRAM output */ + if (flag & 8) { + // Parse input header and use for CRAM output + out->fp.cram->header = sam_hdr_parse_(h->text, h->l_text); + + // Create CRAM references arrays + if (fn_ref) + cram_set_option(out->fp.cram, CRAM_OPT_REFERENCE, fn_ref); + else + // Attempt to fill out a cram->refs[] array from @SQ headers + cram_set_option(out->fp.cram, CRAM_OPT_REFERENCE, NULL); + } + + // Process any options; currently cram only. + for (; in_opts; in_opts = (last=in_opts)->next, free(last)) { + hts_set_opt(in, in_opts->opt, in_opts->val); + if (in_opts->opt == CRAM_OPT_REFERENCE) + hts_set_opt(out, in_opts->opt, in_opts->val); + } + for (; out_opts; out_opts = (last=out_opts)->next, free(last)) + hts_set_opt(out, out_opts->opt, out_opts->val); + + sam_hdr_write(out, h); + if (optind + 1 < argc && !(flag&1)) { // BAM input and has a region + int i; + hts_idx_t *idx; + if ((idx = bam_index_load(argv[optind])) == 0) { + fprintf(stderr, "[E::%s] fail to load the BAM index\n", __func__); + return 1; + } + for (i = optind + 1; i < argc; ++i) { + hts_itr_t *iter; + if ((iter = bam_itr_querys(idx, h, argv[i])) == 0) { + fprintf(stderr, "[E::%s] fail to parse region '%s'\n", __func__, argv[i]); + continue; + } + while ((r = bam_itr_next(in, iter, b)) >= 0) { + if (sam_write1(out, h, b) < 0) { + fprintf(stderr, "Error writing output.\n"); + exit_code = 1; + break; + } + } + hts_itr_destroy(iter); + } + hts_idx_destroy(idx); + } else while ((r = sam_read1(in, h, b)) >= 0) { + if (sam_write1(out, h, b) < 0) { + fprintf(stderr, "Error writing output.\n"); + exit_code = 1; + break; + } + } + + if (r < -1) { + fprintf(stderr, "Error parsing input.\n"); + exit_code = 1; + } + + r = sam_close(out); + if (r < 0) { + fprintf(stderr, "Error closing output.\n"); + exit_code = 1; + } + + bam_destroy1(b); + bam_hdr_destroy(h); + + r = sam_close(in); + if (r < 0) { + fprintf(stderr, "Error closing input.\n"); + exit_code = 1; + } + + return exit_code; +}
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/test_view.pl Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,71 @@ +#! /usr/bin/env perl +# +# Copyright (C) 2013 Genome Research Ltd. +# +# Author: James Bonfield <jkb@sanger.ac.uk> +# +# Permission is hereby granted, free of charge, to any person obtaining a copy +# of this software and associated documentation files (the "Software"), to deal +# in the Software without restriction, including without limitation the rights +# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +# copies of the Software, and to permit persons to whom the Software is +# furnished to do so, subject to the following conditions: +# +# The above copyright notice and this permission notice shall be included in +# all copies or substantial portions of the Software. +# +# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +# DEALINGS IN THE SOFTWARE. +use strict; +use warnings; + +my $err_count = 0; +my $suc_count = 0; + +sub test { + my ($cmd) = @_; + print " $cmd\n"; + if (system("$cmd || exit 1") != 0) { + print "FAIL $!\n"; + $err_count++; + } else { + $suc_count++; + } +} + +foreach my $sam (glob("*#*.sam")) { + my ($base, $ref) = ($sam =~ /((.*)#.*)\.sam/); + $ref .= ".fa"; + + my $bam = "$base.tmp.bam"; + my $cram = "$base.tmp.cram"; + + print "\n=== Testing $sam, ref $ref ===\n"; + + # SAM -> BAM -> SAM + test "./test_view -S -b $sam > $bam"; + test "./test_view $bam > $bam.sam_"; + test "./compare_sam.pl $sam $bam.sam_"; + + # SAM -> CRAM -> SAM + test "./test_view -t $ref -S -C $sam > $cram"; + test "./test_view -D $cram > $cram.sam_"; + test "./compare_sam.pl -nomd $sam $cram.sam_"; + + # BAM -> CRAM -> BAM -> SAM + $cram = "$bam.cram"; + test "./test_view -t $ref -C $bam > $cram"; + test "./test_view -b -D $cram > $cram.bam"; + test "./test_view $cram.bam > $cram.bam.sam_"; + test "./compare_sam.pl -nomd $sam $cram.bam.sam_"; +} + +print "\nSuccesses $suc_count\n"; +print "\nFailures $err_count\n"; + +exit ($err_count > 0);
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx#large_aux.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,4 @@ +@SQ SN:xx LN:20 +a1 16 xx 1 1 10M * 0 0 AAAAAAAAAA * aa:i:1 ab:i:1 ac:i:1 ad:i:1 ae:i:1 af:i:1 ag:i:1 ah:i:1 ai:i:1 aj:i:1 ak:i:1 al:i:1 am:i:1 an:i:1 ao:i:1 ap:i:1 aq:i:1 ar:i:1 as:i:1 at:i:1 au:i:1 av:i:1 aw:i:1 ax:i:1 ay:i:1 az:i:1 ba:i:1 bb:i:1 bc:i:1 bd:i:1 be:i:1 bf:i:1 bg:i:1 bh:i:1 bi:i:1 bj:i:1 bk:i:1 bl:i:1 bm:i:1 bn:i:1 bo:i:1 bp:i:1 bq:i:1 br:i:1 bs:i:1 bt:i:1 bu:i:1 bv:i:1 bw:i:1 bx:i:1 by:i:1 bz:i:1 ca:i:1 cb:i:1 cc:i:1 cd:i:1 ce:i:1 cf:i:1 cg:i:1 ch:i:1 ci:i:1 cj:i:1 ck:i:1 cl:i:1 cm:i:1 cn:i:1 co:i:1 cp:i:1 cq:i:1 cr:i:1 cs:i:1 ct:i:1 cu:i:1 cv:i:1 cw:i:1 cx:i:1 cy:i:1 cz:i:1 da:i:1 db:i:1 dc:i:1 dd:i:1 de:i:1 df:i:1 dg:i:1 dh:i:1 di:i:1 dj:i:1 dk:i:1 dl:i:1 dm:i:1 dn:i:1 do:i:1 dp:i:1 dq:i:1 dr:i:1 ds:i:1 dt:i:1 du:i:1 dv:i:1 dw:i:1 dx:i:1 dy:i:1 dz:i:1 ea:i:1 eb:i:1 ec:i:1 ed:i:1 ee:i:1 ef:i:1 eg:i:1 eh:i:1 ei:i:1 ej:i:1 ek:i:1 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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx#large_aux2.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,11 @@ +@SQ SN:xx LN:20 +a1 0 xx 1 1 1M * 0 0 A # aa:i:1 +a2 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 +a3 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 +a4 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 ad:i:1 +a5 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 ad:i:1 ae:i:1 +a6 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 ad:i:1 ae:i:1 af:i:1 +a7 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 ad:i:1 ae:i:1 af:i:1 ag:i:1 +a8 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 ad:i:1 ae:i:1 af:i:1 ag:i:1 ah:i:1 +a9 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 ad:i:1 ae:i:1 af:i:1 ag:i:1 ah:i:1 ai:i:1 +aA 0 xx 1 1 1M * 0 0 A # aa:i:1 ab:i:1 ac:i:1 ad:i:1 ae:i:1 af:i:1 ag:i:1 ah:i:1 ai:i:1 aj:i:1
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx#minimal.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,10 @@ +@SQ SN:xx LN:20 +@SQ SN:yy LN:20 +a0 16 xx 4 1 10H * 0 0 * * +a1 16 xx 4 1 5H0M5H * 0 0 * * +a2 16 xx 4 1 5H0I10M0D5H * 0 0 * * +A0 16 yy 4 1 0H * 0 0 * * +A1 16 yy 4 1 0I * 0 0 * * +A2 16 yy 4 1 0D * 0 0 * * +A3 16 yy 4 1 0M * 0 0 * * +A4 16 yy 4 1 0P * 0 0 * *
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx#pair.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,7 @@ +@SQ SN:xx LN:20 +a1 99 xx 1 1 10M = 11 20 AAAAAAAAAA ********** +b1 99 xx 1 1 10M = 11 20 AAAAAAAAAA ********** +c1 99 xx 1 1 10M = 11 20 AAAAAAAAAA ********** +a1 147 xx 11 1 10M = 1 -20 TTTTTTTTTT ********** +b1 147 xx 11 1 10M = 1 -20 TTTTTTTTTT ********** +c1 147 xx 11 1 10M = 1 -20 TTTTTTTTTT **********
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx#rg.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,13 @@ +@HD VN:1.4 SO:coordinate +@SQ SN:xx LN:20 AS:? SP:? UR:? M5:bbf4de6d8497a119dda6e074521643dc +@RG ID:x1 SM:x1 +@RG ID:x2 SM:x2 LB:x PG:foo:bar PI:1111 +@PG ID:emacs PN:emacs VN:23.1.1 +@CO also test +@CO other headers +a1 16 xx 1 1 10M * 0 0 AAAAAAAAAA ********** RG:Z:x1 +b1 16 xx 1 1 10M * 0 0 AAAAAAAAAA ********** RG:Z:x2 +c1 16 xx 1 1 10M * 0 0 AAAAAAAAAA ********** +a2 16 xx 11 1 10M * 0 0 TTTTTTTTTT ********** RG:Z:x1 +b2 16 xx 11 1 10M * 0 0 TTTTTTTTTT ********** RG:Z:x2 +c2 16 xx 11 1 10M * 0 0 TTTTTTTTTT **********
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx#triplet.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,7 @@ +@SQ SN:xx LN:20 +@SQ SN:yy LN:20 +a1 67 xx 1 1 10M = 6 20 AAAAAAAAAA ********** +a1 35 xx 6 1 10M = 11 -20 AAAAATTTTT ********** +a1 147 xx 11 1 10M = 1 -20 TTTTTTTTTT ********** +a1 67 yy 1 1 10M = 6 15 AAAAAAAAAA ********** +a1 3 yy 6 1 10M = 1 -15 AAAAATTTTT **********
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx#unsorted.sam Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,8 @@ +@SQ SN:xx LN:20 +@SQ SN:yy LN:20 +b1 147 yy 11 1 10M = 1 -20 TTTTTTTTTT ********** +a1 147 xx 11 1 10M = 1 -20 TTTTTTTTTT ********** +a1 99 xx 1 1 10M = 11 20 AAAAAAAAAA ********** +b1 99 yy 1 1 10M = 11 20 AAAAAAAAAA ********** +c1 99 xx 1 1 10M = 11 20 AAAAAAAAAA ********** +c1 147 xx 11 1 10M = 1 -20 TTTTTTTTTT **********
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx.fa Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +>xx +AAAAAAAAAATTTTTTTTTT +>yy +AAAAAAAAAATTTTTTTTTT +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/test/xx.fa.fai Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,2 @@ +xx 20 4 20 21 +yy 20 29 20 21
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/vcf.5 Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,120 @@ +'\" t +.TH vcf 5 "August 2013" "htslib" "Bioinformatics formats" +.SH NAME +vcf \- Variant Call Format +.\" +.\" Copyright (C) 2011 Broad Institute. +.\" Copyright (C) 2013 Genome Research Ltd. +.\" +.\" Author: Heng Li <lh3@sanger.ac.uk> +.\" +.\" Permission is hereby granted, free of charge, to any person obtaining a +.\" copy of this software and associated documentation files (the "Software"), +.\" to deal in the Software without restriction, including without limitation +.\" the rights to use, copy, modify, merge, publish, distribute, sublicense, +.\" and/or sell copies of the Software, and to permit persons to whom the +.\" Software is furnished to do so, subject to the following conditions: +.\" +.\" The above copyright notice and this permission notice shall be included in +.\" all copies or substantial portions of the Software. +.\" +.\" THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +.\" IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +.\" FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +.\" THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +.\" LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +.\" FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +.\" DEALINGS IN THE SOFTWARE. +.\" +.SH DESCRIPTION +The Variant Call Format (VCF) is a TAB-delimited format with each data line +consisting of the following fields: +.TS +nlbl. +1 CHROM CHROMosome name +2 POS the left-most POSition of the variant +3 ID unique variant IDentifier +4 REF the REFerence allele +5 ALT the ALTernate allele(s) (comma-separated) +6 QUAL variant/reference QUALity +7 FILTER FILTERs applied +8 INFO INFOrmation related to the variant (semicolon-separated) +9 FORMAT FORMAT of the genotype fields (optional; colon-separated) +10+ SAMPLE SAMPLE genotypes and per-sample information (optional) +.TE +.P +The following table gives the \fBINFO\fP tags used by samtools and bcftools. +.TP +.B AF1 +Max-likelihood estimate of the site allele frequency (AF) of the first ALT allele +(double) +.TP +.B DP +Raw read depth (without quality filtering) +(int) +.TP +.B DP4 +# high-quality reference forward bases, ref reverse, alternate for and alt rev bases +(int[4]) +.TP +.B FQ +Consensus quality. Positive: sample genotypes different; negative: otherwise +(int) +.TP +.B MQ +Root-Mean-Square mapping quality of covering reads +(int) +.TP +.B PC2 +Phred probability of AF in group1 samples being larger (,smaller) than in group2 +(int[2]) +.TP +.B PCHI2 +Posterior weighted chi^2 P-value between group1 and group2 samples +(double) +.TP +.B PV4 +P-value for strand bias, baseQ bias, mapQ bias and tail distance bias +(double[4]) +.TP +.B QCHI2 +Phred-scaled PCHI2 +(int) +.TP +.B RP +# permutations yielding a smaller PCHI2 +(int) +.TP +.B CLR +Phred log ratio of genotype likelihoods with and without the trio/pair constraint +(int) +.TP +.B UGT +Most probable genotype configuration without the trio constraint +(string) +.TP +.B CGT +Most probable configuration with the trio constraint +(string) +.TP +.B VDB +Tests variant positions within reads. Intended for filtering RNA-seq artifacts around splice sites +(float) +.TP +.B RPB +Mann-Whitney rank-sum test for tail distance bias +(float) +.TP +.B HWE +Hardy-Weinberg equilibrium test (Wigginton et al) +(float) +.P +.SH SEE ALSO +.TP +https://github.com/samtools/hts-specs +The full VCF/BCF file format specification +.TP +.I A note on exact tests of Hardy-Weinberg equilibrium +Wigginton JE et al +PMID:15789306 +.\" (http://www.ncbi.nlm.nih.gov/pubmed/15789306)
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/vcf.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3212 @@ +/* vcf.c -- VCF/BCF API functions. + + Copyright (C) 2012, 2013 Broad Institute. + Copyright (C) 2012-2014 Genome Research Ltd. + Portions copyright (C) 2014 Intel Corporation. + + Author: Heng Li <lh3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include <zlib.h> +#include <stdio.h> +#include <ctype.h> +#include <assert.h> +#include <string.h> +#include <stdlib.h> +#include <limits.h> +#include "htslib/kstring.h" +#include "htslib/bgzf.h" +#include "htslib/vcf.h" +#include "htslib/tbx.h" +#include "htslib/hfile.h" +#include "htslib/khash_str2int.h" + +#include "htslib/khash.h" +KHASH_MAP_INIT_STR(vdict, bcf_idinfo_t) +typedef khash_t(vdict) vdict_t; + +#include "htslib/kseq.h" +KSTREAM_DECLARE(gzFile, gzread) + +uint32_t bcf_float_missing = 0x7F800001; +uint32_t bcf_float_vector_end = 0x7F800002; +uint8_t bcf_type_shift[] = { 0, 0, 1, 2, 0, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 }; +static bcf_idinfo_t bcf_idinfo_def = { .info = { 15, 15, 15 }, .hrec = { NULL, NULL, NULL}, .id = -1 }; + +/************************* + *** VCF header parser *** + *************************/ + +int bcf_hdr_sync(bcf_hdr_t *h); + +int bcf_hdr_add_sample(bcf_hdr_t *h, const char *s) +{ + if ( !s ) return 0; + + const char *ss = s; + while ( !*ss && isspace(*ss) ) ss++; + if ( !*ss ) + { + fprintf(stderr,"[E::%s] Empty sample name: trailing spaces/tabs in the header line?\n", __func__); + abort(); + } + + vdict_t *d = (vdict_t*)h->dict[BCF_DT_SAMPLE]; + int ret; + char *sdup = strdup(s); + int k = kh_put(vdict, d, sdup, &ret); + if (ret) { // absent + kh_val(d, k) = bcf_idinfo_def; + kh_val(d, k).id = kh_size(d) - 1; + } else { + if (hts_verbose >= 2) + { + fprintf(stderr, "[E::%s] Duplicated sample name '%s'\n", __func__, s); + abort(); + } + free(sdup); + return -1; + } + int n = kh_size(d); + h->samples = (char**) realloc(h->samples,sizeof(char*)*n); + h->samples[n-1] = sdup; + h->dirty = 1; + return 0; +} + +int bcf_hdr_parse_sample_line(bcf_hdr_t *h, const char *str) +{ + int ret = 0; + int i = 0; + const char *p, *q; + // add samples + for (p = q = str;; ++q) { + if (*q != '\t' && *q != 0 && *q != '\n') continue; + if (++i > 9) { + char *s = (char*)malloc(q - p + 1); + strncpy(s, p, q - p); + s[q - p] = 0; + if ( bcf_hdr_add_sample(h,s) < 0 ) ret = -1; + free(s); + } + if (*q == 0 || *q == '\n') break; + p = q + 1; + } + bcf_hdr_add_sample(h,NULL); + return ret; +} + +int bcf_hdr_sync(bcf_hdr_t *h) +{ + int i; + for (i = 0; i < 3; i++) + { + vdict_t *d = (vdict_t*)h->dict[i]; + khint_t k; + + // find out the largest id, there may be holes because of IDX + int max_id = -1; + for (k=kh_begin(d); k<kh_end(d); k++) + { + if (!kh_exist(d,k)) continue; + if ( max_id < kh_val(d,k).id ) max_id = kh_val(d,k).id; + } + if ( max_id >= h->n[i] ) + { + h->id[i] = (bcf_idpair_t*)realloc(h->id[i], (max_id+1)*sizeof(bcf_idpair_t)); + for (k=h->n[i]; k<=max_id; k++) + { + h->id[i][k].key = NULL; + h->id[i][k].val = NULL; + } + h->n[i] = max_id+1; + } + for (k=kh_begin(d); k<kh_end(d); k++) + { + if (!kh_exist(d,k)) continue; + h->id[i][kh_val(d,k).id].key = kh_key(d,k); + h->id[i][kh_val(d,k).id].val = &kh_val(d,k); + } + } + h->dirty = 0; + return 0; +} + +void bcf_hrec_destroy(bcf_hrec_t *hrec) +{ + free(hrec->key); + if ( hrec->value ) free(hrec->value); + int i; + for (i=0; i<hrec->nkeys; i++) + { + free(hrec->keys[i]); + free(hrec->vals[i]); + } + free(hrec->keys); + free(hrec->vals); + free(hrec); +} + +// Copies all fields except IDX. +bcf_hrec_t *bcf_hrec_dup(bcf_hrec_t *hrec) +{ + bcf_hrec_t *out = (bcf_hrec_t*) calloc(1,sizeof(bcf_hrec_t)); + out->type = hrec->type; + if ( hrec->key ) out->key = strdup(hrec->key); + if ( hrec->value ) out->value = strdup(hrec->value); + out->nkeys = hrec->nkeys; + out->keys = (char**) malloc(sizeof(char*)*hrec->nkeys); + out->vals = (char**) malloc(sizeof(char*)*hrec->nkeys); + int i, j = 0; + for (i=0; i<hrec->nkeys; i++) + { + if ( hrec->keys[i] && !strcmp("IDX",hrec->keys[i]) ) continue; + if ( hrec->keys[i] ) out->keys[j] = strdup(hrec->keys[i]); + if ( hrec->vals[i] ) out->vals[j] = strdup(hrec->vals[i]); + j++; + } + if ( i!=j ) out->nkeys -= i-j; // IDX was omitted + return out; +} + +void bcf_hrec_debug(FILE *fp, bcf_hrec_t *hrec) +{ + fprintf(fp, "key=[%s] value=[%s]", hrec->key, hrec->value?hrec->value:""); + int i; + for (i=0; i<hrec->nkeys; i++) + fprintf(fp, "\t[%s]=[%s]", hrec->keys[i],hrec->vals[i]); + fprintf(fp, "\n"); +} + +void bcf_header_debug(bcf_hdr_t *hdr) +{ + int i, j; + for (i=0; i<hdr->nhrec; i++) + { + if ( !hdr->hrec[i]->value ) + { + fprintf(stderr, "##%s=<", hdr->hrec[i]->key); + fprintf(stderr,"%s=%s", hdr->hrec[i]->keys[0], hdr->hrec[i]->vals[0]); + for (j=1; j<hdr->hrec[i]->nkeys; j++) + fprintf(stderr,",%s=%s", hdr->hrec[i]->keys[j], hdr->hrec[i]->vals[j]); + fprintf(stderr,">\n"); + } + else + fprintf(stderr,"##%s=%s\n", hdr->hrec[i]->key,hdr->hrec[i]->value); + } +} + +void bcf_hrec_add_key(bcf_hrec_t *hrec, const char *str, int len) +{ + int n = ++hrec->nkeys; + hrec->keys = (char**) realloc(hrec->keys, sizeof(char*)*n); + hrec->vals = (char**) realloc(hrec->vals, sizeof(char*)*n); + assert( len ); + hrec->keys[n-1] = (char*) malloc((len+1)*sizeof(char)); + memcpy(hrec->keys[n-1],str,len); + hrec->keys[n-1][len] = 0; + hrec->vals[n-1] = NULL; +} + +void bcf_hrec_set_val(bcf_hrec_t *hrec, int i, const char *str, int len, int is_quoted) +{ + if ( !str ) { hrec->vals[i] = NULL; return; } + if ( hrec->vals[i] ) free(hrec->vals[i]); + if ( is_quoted ) + { + hrec->vals[i] = (char*) malloc((len+3)*sizeof(char)); + hrec->vals[i][0] = '"'; + memcpy(&hrec->vals[i][1],str,len); + hrec->vals[i][len+1] = '"'; + hrec->vals[i][len+2] = 0; + } + else + { + hrec->vals[i] = (char*) malloc((len+1)*sizeof(char)); + memcpy(hrec->vals[i],str,len); + hrec->vals[i][len] = 0; + } +} + +void hrec_add_idx(bcf_hrec_t *hrec, int idx) +{ + int n = ++hrec->nkeys; + hrec->keys = (char**) realloc(hrec->keys, sizeof(char*)*n); + hrec->vals = (char**) realloc(hrec->vals, sizeof(char*)*n); + hrec->keys[n-1] = strdup("IDX"); + kstring_t str = {0,0,0}; + kputw(idx, &str); + hrec->vals[n-1] = str.s; +} + +int bcf_hrec_find_key(bcf_hrec_t *hrec, const char *key) +{ + int i; + for (i=0; i<hrec->nkeys; i++) + if ( !strcasecmp(key,hrec->keys[i]) ) return i; + return -1; +} + +static inline int is_escaped(const char *min, const char *str) +{ + int n = 0; + while ( --str>=min && *str=='\\' ) n++; + return n%2; +} + +bcf_hrec_t *bcf_hdr_parse_line(const bcf_hdr_t *h, const char *line, int *len) +{ + const char *p = line; + if (p[0] != '#' || p[1] != '#') { *len = 0; return NULL; } + p += 2; + + const char *q = p; + while ( *q && *q!='=' ) q++; + int n = q-p; + if ( *q!='=' || !n ) { *len = q-line+1; return NULL; } // wrong format + + bcf_hrec_t *hrec = (bcf_hrec_t*) calloc(1,sizeof(bcf_hrec_t)); + hrec->key = (char*) malloc(sizeof(char)*(n+1)); + memcpy(hrec->key,p,n); + hrec->key[n] = 0; + + p = ++q; + if ( *p!='<' ) // generic field, e.g. ##samtoolsVersion=0.1.18-r579 + { + while ( *q && *q!='\n' ) q++; + hrec->value = (char*) malloc((q-p+1)*sizeof(char)); + memcpy(hrec->value, p, q-p); + hrec->value[q-p] = 0; + *len = q-line+1; + return hrec; + } + + // structured line, e.g. ##INFO=<ID=PV1,Number=1,Type=Float,Description="P-value for baseQ bias"> + int nopen = 1; + while ( *q && *q!='\n' && nopen ) + { + p = ++q; + while ( *q && isalnum(*q) ) q++; + n = q-p; + if ( *q!='=' || !n ) + { + // wrong format + while ( *q && *q!='\n' ) q++; + kstring_t tmp = {0,0,0}; + kputsn(line,q-line,&tmp); + fprintf(stderr,"Could not parse the header line: \"%s\"\n", tmp.s); + free(tmp.s); + *len = q-line+1; + bcf_hrec_destroy(hrec); + return NULL; + } + bcf_hrec_add_key(hrec, p, q-p); + p = ++q; + int quoted = *p=='"' ? 1 : 0; + if ( quoted ) p++, q++; + while (1) + { + if ( !*q ) break; + if ( quoted ) { if ( *q=='"' && !is_escaped(p,q) ) break; } + else + { + if ( *q=='<' ) nopen++; + if ( *q=='>' ) nopen--; + if ( !nopen ) break; + if ( *q==',' && nopen==1 ) break; + } + q++; + } + bcf_hrec_set_val(hrec, hrec->nkeys-1, p, q-p, quoted); + if ( quoted ) q++; + if ( *q=='>' ) { nopen--; q++; } + } + *len = q-line+1; + return hrec; +} + +// returns: 1 when hdr needs to be synced, 0 otherwise +int bcf_hdr_register_hrec(bcf_hdr_t *hdr, bcf_hrec_t *hrec) +{ + // contig + int i,j,k, ret; + char *str; + if ( !strcmp(hrec->key, "contig") ) + { + hrec->type = BCF_HL_CTG; + + // Get the contig ID ($str) and length ($j) + i = bcf_hrec_find_key(hrec,"length"); + if ( i<0 ) j = 0; + else if ( sscanf(hrec->vals[i],"%d",&j)!=1 ) return 0; + + i = bcf_hrec_find_key(hrec,"ID"); + if ( i<0 ) return 0; + str = strdup(hrec->vals[i]); + + // Register in the dictionary + vdict_t *d = (vdict_t*)hdr->dict[BCF_DT_CTG]; + k = kh_put(vdict, d, str, &ret); + if ( !ret ) { free(str); return 0; } // already present + + int idx = bcf_hrec_find_key(hrec,"IDX"); + if ( idx!=-1 ) + { + char *tmp = hrec->vals[idx]; + idx = strtol(hrec->vals[idx], &tmp, 10); + if ( *tmp ) + { + fprintf(stderr,"[%s:%d %s] Error parsing the IDX tag, skipping.\n", __FILE__,__LINE__,__FUNCTION__); + return 0; + } + } + else + { + idx = kh_size(d) - 1; + hrec_add_idx(hrec, idx); + } + + kh_val(d, k) = bcf_idinfo_def; + kh_val(d, k).id = idx; + kh_val(d, k).info[0] = j; + kh_val(d, k).hrec[0] = hrec; + + return 1; + } + + if ( !strcmp(hrec->key, "INFO") ) hrec->type = BCF_HL_INFO; + else if ( !strcmp(hrec->key, "FILTER") ) hrec->type = BCF_HL_FLT; + else if ( !strcmp(hrec->key, "FORMAT") ) hrec->type = BCF_HL_FMT; + else if ( hrec->nkeys>0 ) { hrec->type = BCF_HL_STR; return 1; } + else return 0; + + // INFO/FILTER/FORMAT + char *id = NULL; + int type = -1, num = -1, var = -1, idx = -1; + for (i=0; i<hrec->nkeys; i++) + { + if ( !strcmp(hrec->keys[i], "ID") ) id = hrec->vals[i]; + else if ( !strcmp(hrec->keys[i], "IDX") ) + { + char *tmp = hrec->vals[i]; + idx = strtol(hrec->vals[i], &tmp, 10); + if ( *tmp ) + { + fprintf(stderr,"[%s:%d %s] Error parsing the IDX tag, skipping.\n", __FILE__,__LINE__,__FUNCTION__); + return 0; + } + } + else if ( !strcmp(hrec->keys[i], "Type") ) + { + if ( !strcmp(hrec->vals[i], "Integer") ) type = BCF_HT_INT; + else if ( !strcmp(hrec->vals[i], "Float") ) type = BCF_HT_REAL; + else if ( !strcmp(hrec->vals[i], "String") ) type = BCF_HT_STR; + else if ( !strcmp(hrec->vals[i], "Character") ) type = BCF_HT_STR; + else if ( !strcmp(hrec->vals[i], "Flag") ) type = BCF_HT_FLAG; + else + { + fprintf(stderr, "[E::%s] The type \"%s\" not supported, assuming \"String\"\n", __func__, hrec->vals[i]); + type = BCF_HT_STR; + } + } + else if ( !strcmp(hrec->keys[i], "Number") ) + { + if ( !strcmp(hrec->vals[i],"A") ) var = BCF_VL_A; + else if ( !strcmp(hrec->vals[i],"R") ) var = BCF_VL_R; + else if ( !strcmp(hrec->vals[i],"G") ) var = BCF_VL_G; + else if ( !strcmp(hrec->vals[i],".") ) var = BCF_VL_VAR; + else + { + sscanf(hrec->vals[i],"%d",&num); + var = BCF_VL_FIXED; + } + if (var != BCF_VL_FIXED) num = 0xfffff; + } + } + uint32_t info = (uint32_t)num<<12 | var<<8 | type<<4 | hrec->type; + + if ( !id ) return 0; + str = strdup(id); + + vdict_t *d = (vdict_t*)hdr->dict[BCF_DT_ID]; + k = kh_put(vdict, d, str, &ret); + if ( !ret ) + { + // already present + free(str); + if ( kh_val(d, k).hrec[info&0xf] ) return 0; + kh_val(d, k).info[info&0xf] = info; + kh_val(d, k).hrec[info&0xf] = hrec; + if ( idx==-1 ) hrec_add_idx(hrec, kh_val(d, k).id); + return 1; + } + kh_val(d, k) = bcf_idinfo_def; + kh_val(d, k).info[info&0xf] = info; + kh_val(d, k).hrec[info&0xf] = hrec; + kh_val(d, k).id = idx==-1 ? kh_size(d) - 1 : idx; + + if ( idx==-1 ) hrec_add_idx(hrec, kh_val(d, k).id); + + return 1; +} + +int bcf_hdr_add_hrec(bcf_hdr_t *hdr, bcf_hrec_t *hrec) +{ + if ( !hrec ) return 0; + + hrec->type = BCF_HL_GEN; + if ( !bcf_hdr_register_hrec(hdr,hrec) ) + { + // If one of the hashed field, then it is already present + if ( hrec->type != BCF_HL_GEN ) + { + bcf_hrec_destroy(hrec); + return 0; + } + + // Is one of the generic fields and already present? + int i; + for (i=0; i<hdr->nhrec; i++) + { + if ( hdr->hrec[i]->type!=BCF_HL_GEN ) continue; + if ( !strcmp(hdr->hrec[i]->key,hrec->key) && !strcmp(hrec->key,"fileformat") ) break; + if ( !strcmp(hdr->hrec[i]->key,hrec->key) && !strcmp(hdr->hrec[i]->value,hrec->value) ) break; + } + if ( i<hdr->nhrec ) + { + bcf_hrec_destroy(hrec); + return 0; + } + } + + // New record, needs to be added + int n = ++hdr->nhrec; + hdr->hrec = (bcf_hrec_t**) realloc(hdr->hrec, n*sizeof(bcf_hrec_t*)); + hdr->hrec[n-1] = hrec; + hdr->dirty = 1; + + return hrec->type==BCF_HL_GEN ? 0 : 1; +} + +/* + * Note that while querying of FLT,INFO,FMT,CTG lines is fast (the keys are hashed), + * the STR,GEN lines are searched for linearly in a linked list of all header lines. + * This may become a problem for VCFs with huge headers, we might need to build a + * dictionary for these lines as well. + */ +bcf_hrec_t *bcf_hdr_get_hrec(const bcf_hdr_t *hdr, int type, const char *key, const char *value, const char *str_class) +{ + int i; + if ( type==BCF_HL_GEN ) + { + for (i=0; i<hdr->nhrec; i++) + { + if ( hdr->hrec[i]->type!=type ) continue; + if ( strcmp(hdr->hrec[i]->key,key) ) continue; + if ( !value || !strcmp(hdr->hrec[i]->value,value) ) return hdr->hrec[i]; + } + return NULL; + } + else if ( type==BCF_HL_STR ) + { + for (i=0; i<hdr->nhrec; i++) + { + if ( hdr->hrec[i]->type!=type ) continue; + if ( strcmp(hdr->hrec[i]->key,str_class) ) continue; + int j = bcf_hrec_find_key(hdr->hrec[i],key); + if ( j>=0 && !strcmp(hdr->hrec[i]->vals[j],value) ) return hdr->hrec[i]; + } + return NULL; + } + vdict_t *d = type==BCF_HL_CTG ? (vdict_t*)hdr->dict[BCF_DT_CTG] : (vdict_t*)hdr->dict[BCF_DT_ID]; + khint_t k = kh_get(vdict, d, value); + if ( k == kh_end(d) ) return NULL; + return kh_val(d, k).hrec[type==BCF_HL_CTG?0:type]; +} + +void bcf_hdr_check_sanity(bcf_hdr_t *hdr) +{ + static int PL_warned = 0, GL_warned = 0; + + if ( !PL_warned ) + { + int id = bcf_hdr_id2int(hdr, BCF_DT_ID, "PL"); + if ( bcf_hdr_idinfo_exists(hdr,BCF_HL_FMT,id) && bcf_hdr_id2length(hdr,BCF_HL_FMT,id)!=BCF_VL_G ) + { + fprintf(stderr,"[W::%s] PL should be declared as Number=G\n", __func__); + PL_warned = 1; + } + } + if ( !GL_warned ) + { + int id = bcf_hdr_id2int(hdr, BCF_HL_FMT, "GL"); + if ( bcf_hdr_idinfo_exists(hdr,BCF_HL_FMT,id) && bcf_hdr_id2length(hdr,BCF_HL_FMT,id)!=BCF_VL_G ) + { + fprintf(stderr,"[W::%s] GL should be declared as Number=G\n", __func__); + PL_warned = 1; + } + } +} + +int bcf_hdr_parse(bcf_hdr_t *hdr, char *htxt) +{ + int len, needs_sync = 0; + char *p = htxt; + + // Check sanity: "fileformat" string must come as first + bcf_hrec_t *hrec = bcf_hdr_parse_line(hdr,p,&len); + if ( !hrec || !hrec->key || strcasecmp(hrec->key,"fileformat") ) + fprintf(stderr, "[W::%s] The first line should be ##fileformat; is the VCF/BCF header broken?\n", __func__); + needs_sync += bcf_hdr_add_hrec(hdr, hrec); + + // The filter PASS must appear first in the dictionary + hrec = bcf_hdr_parse_line(hdr,"##FILTER=<ID=PASS,Description=\"All filters passed\">",&len); + needs_sync += bcf_hdr_add_hrec(hdr, hrec); + + // Parse the whole header + while ( (hrec=bcf_hdr_parse_line(hdr,p,&len)) ) + { + needs_sync += bcf_hdr_add_hrec(hdr, hrec); + p += len; + } + int ret = bcf_hdr_parse_sample_line(hdr,p); + bcf_hdr_sync(hdr); + bcf_hdr_check_sanity(hdr); + return ret; +} + +int bcf_hdr_append(bcf_hdr_t *hdr, const char *line) +{ + int len; + bcf_hrec_t *hrec = bcf_hdr_parse_line(hdr, (char*) line, &len); + if ( !hrec ) return -1; + bcf_hdr_add_hrec(hdr, hrec); + return 0; +} + +void bcf_hdr_remove(bcf_hdr_t *hdr, int type, const char *key) +{ + int i; + bcf_hrec_t *hrec; + while (1) + { + if ( type==BCF_HL_FLT || type==BCF_HL_INFO || type==BCF_HL_FMT || type== BCF_HL_CTG ) + { + hrec = bcf_hdr_get_hrec(hdr, type, "ID", key, NULL); + if ( !hrec ) return; + + for (i=0; i<hdr->nhrec; i++) + if ( hdr->hrec[i]==hrec ) break; + assert( i<hdr->nhrec ); + + vdict_t *d = type==BCF_HL_CTG ? (vdict_t*)hdr->dict[BCF_DT_CTG] : (vdict_t*)hdr->dict[BCF_DT_ID]; + khint_t k = kh_get(vdict, d, key); + kh_val(d, k).hrec[type==BCF_HL_CTG?0:type] = NULL; + } + else + { + for (i=0; i<hdr->nhrec; i++) + { + if ( hdr->hrec[i]->type!=type ) continue; + if ( type==BCF_HL_GEN ) + { + if ( !strcmp(hdr->hrec[i]->key,key) ) break; + } + else + { + // not all structured lines have ID, we could be more sophisticated as in bcf_hdr_get_hrec() + int j = bcf_hrec_find_key(hdr->hrec[i], "ID"); + if ( j>=0 && !strcmp(hdr->hrec[i]->vals[j],key) ) break; + } + } + if ( i==hdr->nhrec ) return; + hrec = hdr->hrec[i]; + } + + hdr->nhrec--; + if ( i < hdr->nhrec ) + memmove(&hdr->hrec[i],&hdr->hrec[i+1],(hdr->nhrec-i)*sizeof(bcf_hrec_t*)); + bcf_hrec_destroy(hrec); + hdr->dirty = 1; + } +} + +int bcf_hdr_printf(bcf_hdr_t *hdr, const char *fmt, ...) +{ + va_list ap; + va_start(ap, fmt); + int n = vsnprintf(NULL, 0, fmt, ap) + 2; + va_end(ap); + + char *line = (char*)malloc(n); + va_start(ap, fmt); + vsnprintf(line, n, fmt, ap); + va_end(ap); + + int ret = bcf_hdr_append(hdr, line); + + free(line); + return ret; +} + + +/********************** + *** BCF header I/O *** + **********************/ + +const char *bcf_hdr_get_version(const bcf_hdr_t *hdr) +{ + bcf_hrec_t *hrec = bcf_hdr_get_hrec(hdr, BCF_HL_GEN, "fileformat", NULL, NULL); + if ( !hrec ) + { + fprintf(stderr,"No version string found, assuming VCFv4.2\n"); + return "VCFv4.2"; + } + return hrec->value; +} + +void bcf_hdr_set_version(bcf_hdr_t *hdr, const char *version) +{ + bcf_hrec_t *hrec = bcf_hdr_get_hrec(hdr, BCF_HL_GEN, "fileformat", NULL, NULL); + if ( !hrec ) + { + int len; + kstring_t str = {0,0,0}; + ksprintf(&str,"##fileformat=%s", version); + hrec = bcf_hdr_parse_line(hdr, str.s, &len); + free(str.s); + } + else + { + free(hrec->value); + hrec->value = strdup(version); + } + hdr->dirty = 1; +} + +bcf_hdr_t *bcf_hdr_init(const char *mode) +{ + int i; + bcf_hdr_t *h; + h = (bcf_hdr_t*)calloc(1, sizeof(bcf_hdr_t)); + for (i = 0; i < 3; ++i) + h->dict[i] = kh_init(vdict); + if ( strchr(mode,'w') ) + { + bcf_hdr_append(h, "##fileformat=VCFv4.2"); + // The filter PASS must appear first in the dictionary + bcf_hdr_append(h, "##FILTER=<ID=PASS,Description=\"All filters passed\">"); + } + return h; +} + +void bcf_hdr_destroy(bcf_hdr_t *h) +{ + int i; + khint_t k; + for (i = 0; i < 3; ++i) { + vdict_t *d = (vdict_t*)h->dict[i]; + if (d == 0) continue; + for (k = kh_begin(d); k != kh_end(d); ++k) + if (kh_exist(d, k)) free((char*)kh_key(d, k)); + kh_destroy(vdict, d); + free(h->id[i]); + } + for (i=0; i<h->nhrec; i++) + bcf_hrec_destroy(h->hrec[i]); + if (h->nhrec) free(h->hrec); + if (h->samples) free(h->samples); + free(h->keep_samples); + free(h->transl[0]); free(h->transl[1]); + free(h->mem.s); + free(h); +} + +bcf_hdr_t *bcf_hdr_read(htsFile *hfp) +{ + if (hfp->format.format == vcf) + return vcf_hdr_read(hfp); + + BGZF *fp = hfp->fp.bgzf; + uint8_t magic[5]; + bcf_hdr_t *h; + h = bcf_hdr_init("r"); + if ( bgzf_read(fp, magic, 5)<0 ) + { + fprintf(stderr,"[%s:%d %s] Failed to read the header (reading BCF in text mode?)\n", __FILE__,__LINE__,__FUNCTION__); + return NULL; + } + if (strncmp((char*)magic, "BCF\2\2", 5) != 0) + { + if (!strncmp((char*)magic, "BCF", 3)) + fprintf(stderr,"[%s:%d %s] invalid BCF2 magic string: only BCFv2.2 is supported.\n", __FILE__,__LINE__,__FUNCTION__); + else if (hts_verbose >= 2) + fprintf(stderr, "[E::%s] invalid BCF2 magic string\n", __func__); + bcf_hdr_destroy(h); + return 0; + } + int hlen; + char *htxt; + bgzf_read(fp, &hlen, 4); + htxt = (char*)malloc(hlen); + bgzf_read(fp, htxt, hlen); + bcf_hdr_parse(h, htxt); + free(htxt); + return h; +} + +int bcf_hdr_write(htsFile *hfp, bcf_hdr_t *h) +{ + if ( h->dirty ) bcf_hdr_sync(h); + if (hfp->format.format == vcf || hfp->format.format == text_format) + return vcf_hdr_write(hfp, h); + + int hlen; + char *htxt = bcf_hdr_fmt_text(h, 1, &hlen); + hlen++; // include the \0 byte + + BGZF *fp = hfp->fp.bgzf; + if ( bgzf_write(fp, "BCF\2\2", 5) !=5 ) return -1; + if ( bgzf_write(fp, &hlen, 4) !=4 ) return -1; + if ( bgzf_write(fp, htxt, hlen) != hlen ) return -1; + + free(htxt); + return 0; +} + +/******************** + *** BCF site I/O *** + ********************/ + +bcf1_t *bcf_init1() +{ + bcf1_t *v; + v = (bcf1_t*)calloc(1, sizeof(bcf1_t)); + return v; +} + +void bcf_clear(bcf1_t *v) +{ + int i; + for (i=0; i<v->d.m_info; i++) + { + if ( v->d.info[i].vptr_free ) + { + free(v->d.info[i].vptr - v->d.info[i].vptr_off); + v->d.info[i].vptr_free = 0; + } + } + for (i=0; i<v->d.m_fmt; i++) + { + if ( v->d.fmt[i].p_free ) + { + free(v->d.fmt[i].p - v->d.fmt[i].p_off); + v->d.fmt[i].p_free = 0; + } + } + v->rid = v->pos = v->rlen = v->unpacked = 0; + bcf_float_set_missing(v->qual); + v->n_info = v->n_allele = v->n_fmt = v->n_sample = 0; + v->shared.l = v->indiv.l = 0; + v->d.var_type = -1; + v->d.shared_dirty = 0; + v->d.indiv_dirty = 0; + v->d.n_flt = 0; + v->errcode = 0; + if (v->d.m_als) v->d.als[0] = 0; + if (v->d.m_id) v->d.id[0] = 0; +} + +void bcf_empty1(bcf1_t *v) +{ + bcf_clear1(v); + free(v->d.id); + free(v->d.als); + free(v->d.allele); free(v->d.flt); free(v->d.info); free(v->d.fmt); + if (v->d.var ) free(v->d.var); + free(v->shared.s); free(v->indiv.s); +} + +void bcf_destroy1(bcf1_t *v) +{ + bcf_empty1(v); + free(v); +} + +static inline int bcf_read1_core(BGZF *fp, bcf1_t *v) +{ + uint32_t x[8]; + int ret; + if ((ret = bgzf_read(fp, x, 32)) != 32) { + if (ret == 0) return -1; + return -2; + } + bcf_clear1(v); + x[0] -= 24; // to exclude six 32-bit integers + ks_resize(&v->shared, x[0]); + ks_resize(&v->indiv, x[1]); + memcpy(v, x + 2, 16); + v->n_allele = x[6]>>16; v->n_info = x[6]&0xffff; + v->n_fmt = x[7]>>24; v->n_sample = x[7]&0xffffff; + v->shared.l = x[0], v->indiv.l = x[1]; + + // silent fix of broken BCFs produced by earlier versions of bcf_subset, prior to and including bd6ed8b4 + if ( (!v->indiv.l || !v->n_sample) && v->n_fmt ) v->n_fmt = 0; + + bgzf_read(fp, v->shared.s, v->shared.l); + bgzf_read(fp, v->indiv.s, v->indiv.l); + return 0; +} + +#define bit_array_size(n) ((n)/8+1) +#define bit_array_set(a,i) ((a)[(i)/8] |= 1 << ((i)%8)) +#define bit_array_clear(a,i) ((a)[(i)/8] &= ~(1 << ((i)%8))) +#define bit_array_test(a,i) ((a)[(i)/8] & (1 << ((i)%8))) + +static inline uint8_t *bcf_unpack_fmt_core1(uint8_t *ptr, int n_sample, bcf_fmt_t *fmt); +int bcf_subset_format(const bcf_hdr_t *hdr, bcf1_t *rec) +{ + if ( !hdr->keep_samples ) return 0; + if ( !bcf_hdr_nsamples(hdr) ) + { + rec->indiv.l = rec->n_sample = 0; + return 0; + } + + int i, j; + uint8_t *ptr = (uint8_t*)rec->indiv.s, *dst = NULL, *src; + bcf_dec_t *dec = &rec->d; + hts_expand(bcf_fmt_t, rec->n_fmt, dec->m_fmt, dec->fmt); + for (i=0; i<dec->m_fmt; ++i) dec->fmt[i].p_free = 0; + + for (i=0; i<rec->n_fmt; i++) + { + ptr = bcf_unpack_fmt_core1(ptr, rec->n_sample, &dec->fmt[i]); + src = dec->fmt[i].p - dec->fmt[i].size; + if ( dst ) + { + memmove(dec->fmt[i-1].p + dec->fmt[i-1].p_len, dec->fmt[i].p - dec->fmt[i].p_off, dec->fmt[i].p_off); + dec->fmt[i].p = dec->fmt[i-1].p + dec->fmt[i-1].p_len + dec->fmt[i].p_off; + } + dst = dec->fmt[i].p; + for (j=0; j<hdr->nsamples_ori; j++) + { + src += dec->fmt[i].size; + if ( !bit_array_test(hdr->keep_samples,j) ) continue; + memmove(dst, src, dec->fmt[i].size); + dst += dec->fmt[i].size; + } + rec->indiv.l -= dec->fmt[i].p_len - (dst - dec->fmt[i].p); + dec->fmt[i].p_len = dst - dec->fmt[i].p; + } + rec->unpacked |= BCF_UN_FMT; + + rec->n_sample = bcf_hdr_nsamples(hdr); + return 0; +} + +int bcf_read(htsFile *fp, const bcf_hdr_t *h, bcf1_t *v) +{ + if (fp->format.format == vcf) return vcf_read(fp,h,v); + int ret = bcf_read1_core(fp->fp.bgzf, v); + if ( ret!=0 || !h->keep_samples ) return ret; + return bcf_subset_format(h,v); +} + +int bcf_readrec(BGZF *fp, void *null, void *vv, int *tid, int *beg, int *end) +{ + bcf1_t *v = (bcf1_t *) vv; + int ret; + if ((ret = bcf_read1_core(fp, v)) >= 0) + *tid = v->rid, *beg = v->pos, *end = v->pos + v->rlen; + return ret; +} + +static inline void bcf1_sync_id(bcf1_t *line, kstring_t *str) +{ + // single typed string + if ( line->d.id && strcmp(line->d.id, ".") ) bcf_enc_vchar(str, strlen(line->d.id), line->d.id); + else bcf_enc_size(str, 0, BCF_BT_CHAR); +} +static inline void bcf1_sync_alleles(bcf1_t *line, kstring_t *str) +{ + // list of typed strings + int i; + for (i=0; i<line->n_allele; i++) + bcf_enc_vchar(str, strlen(line->d.allele[i]), line->d.allele[i]); + if ( !line->rlen && line->n_allele ) line->rlen = strlen(line->d.allele[0]); +} +static inline void bcf1_sync_filter(bcf1_t *line, kstring_t *str) +{ + // typed vector of integers + if ( line->d.n_flt ) bcf_enc_vint(str, line->d.n_flt, line->d.flt, -1); + else bcf_enc_vint(str, 0, 0, -1); +} + +static inline void bcf1_sync_info(bcf1_t *line, kstring_t *str) +{ + // pairs of typed vectors + int i, irm = -1; + for (i=0; i<line->n_info; i++) + { + bcf_info_t *info = &line->d.info[i]; + if ( !info->vptr ) + { + // marked for removal + if ( irm < 0 ) irm = i; + continue; + } + kputsn_(info->vptr - info->vptr_off, info->vptr_len + info->vptr_off, str); + if ( irm >=0 ) + { + bcf_info_t tmp = line->d.info[irm]; line->d.info[irm] = line->d.info[i]; line->d.info[i] = tmp; + while ( irm<=i && line->d.info[irm].vptr ) irm++; + } + } + if ( irm>=0 ) line->n_info = irm; +} + +static int bcf1_sync(bcf1_t *line) +{ + char *shared_ori = line->shared.s; + size_t prev_len; + + kstring_t tmp = {0,0,0}; + if ( !line->shared.l ) + { + // New line created via API, BCF data blocks do not exist. Get it ready for BCF output + tmp = line->shared; + bcf1_sync_id(line, &tmp); + line->unpack_size[0] = tmp.l; prev_len = tmp.l; + + bcf1_sync_alleles(line, &tmp); + line->unpack_size[1] = tmp.l - prev_len; prev_len = tmp.l; + + bcf1_sync_filter(line, &tmp); + line->unpack_size[2] = tmp.l - prev_len; + + bcf1_sync_info(line, &tmp); + line->shared = tmp; + } + else if ( line->d.shared_dirty ) + { + // The line was edited, update the BCF data block, ptr_ori points + // to the original unchanged BCF data. + uint8_t *ptr_ori = (uint8_t *) line->shared.s; + + assert( line->unpacked & BCF_UN_STR ); + + // ID: single typed string + if ( line->d.shared_dirty & BCF1_DIRTY_ID ) + bcf1_sync_id(line, &tmp); + else + kputsn_(ptr_ori, line->unpack_size[0], &tmp); + ptr_ori += line->unpack_size[0]; + line->unpack_size[0] = tmp.l; prev_len = tmp.l; + + // REF+ALT: list of typed strings + if ( line->d.shared_dirty & BCF1_DIRTY_ALS ) + bcf1_sync_alleles(line, &tmp); + else + { + kputsn_(ptr_ori, line->unpack_size[1], &tmp); + if ( !line->rlen && line->n_allele ) line->rlen = strlen(line->d.allele[0]); + } + ptr_ori += line->unpack_size[1]; + line->unpack_size[1] = tmp.l - prev_len; prev_len = tmp.l; + + if ( line->unpacked & BCF_UN_FLT ) + { + // FILTER: typed vector of integers + if ( line->d.shared_dirty & BCF1_DIRTY_FLT ) + bcf1_sync_filter(line, &tmp); + else if ( line->d.n_flt ) + kputsn_(ptr_ori, line->unpack_size[2], &tmp); + else + bcf_enc_vint(&tmp, 0, 0, -1); + ptr_ori += line->unpack_size[2]; + line->unpack_size[2] = tmp.l - prev_len; + + if ( line->unpacked & BCF_UN_INFO ) + { + // INFO: pairs of typed vectors + if ( line->d.shared_dirty & BCF1_DIRTY_INF ) + { + bcf1_sync_info(line, &tmp); + ptr_ori = (uint8_t*)line->shared.s + line->shared.l; + } + } + } + + int size = line->shared.l - (size_t)ptr_ori + (size_t)line->shared.s; + if ( size ) kputsn_(ptr_ori, size, &tmp); + + free(line->shared.s); + line->shared = tmp; + } + if ( line->shared.s != shared_ori && line->unpacked & BCF_UN_INFO ) + { + // Reallocated line->shared.s block invalidated line->d.info[].vptr pointers + size_t off_new = line->unpack_size[0] + line->unpack_size[1] + line->unpack_size[2]; + int i; + for (i=0; i<line->n_info; i++) + { + uint8_t *vptr_free = line->d.info[i].vptr_free ? line->d.info[i].vptr - line->d.info[i].vptr_off : NULL; + line->d.info[i].vptr = (uint8_t*) line->shared.s + off_new + line->d.info[i].vptr_off; + off_new += line->d.info[i].vptr_len + line->d.info[i].vptr_off; + if ( vptr_free ) + { + free(vptr_free); + line->d.info[i].vptr_free = 0; + } + } + } + + if ( line->n_sample && line->n_fmt && (!line->indiv.l || line->d.indiv_dirty) ) + { + // The genotype fields changed or are not present + tmp.l = tmp.m = 0; tmp.s = NULL; + int i, irm = -1; + for (i=0; i<line->n_fmt; i++) + { + bcf_fmt_t *fmt = &line->d.fmt[i]; + if ( !fmt->p ) + { + // marked for removal + if ( irm < 0 ) irm = i; + continue; + } + kputsn_(fmt->p - fmt->p_off, fmt->p_len + fmt->p_off, &tmp); + if ( irm >=0 ) + { + bcf_fmt_t tfmt = line->d.fmt[irm]; line->d.fmt[irm] = line->d.fmt[i]; line->d.fmt[i] = tfmt; + while ( irm<=i && line->d.fmt[irm].p ) irm++; + } + + } + if ( irm>=0 ) line->n_fmt = irm; + free(line->indiv.s); + line->indiv = tmp; + + // Reallocated line->indiv.s block invalidated line->d.fmt[].p pointers + size_t off_new = 0; + for (i=0; i<line->n_fmt; i++) + { + uint8_t *p_free = line->d.fmt[i].p_free ? line->d.fmt[i].p - line->d.fmt[i].p_off : NULL; + line->d.fmt[i].p = (uint8_t*) line->indiv.s + off_new + line->d.fmt[i].p_off; + off_new += line->d.fmt[i].p_len + line->d.fmt[i].p_off; + if ( p_free ) + { + free(p_free); + line->d.fmt[i].p_free = 0; + } + } + } + if ( !line->n_sample ) line->n_fmt = 0; + line->d.shared_dirty = line->d.indiv_dirty = 0; + return 0; +} + +bcf1_t *bcf_copy(bcf1_t *dst, bcf1_t *src) +{ + bcf1_sync(src); + + bcf_clear(dst); + dst->rid = src->rid; + dst->pos = src->pos; + dst->rlen = src->rlen; + dst->qual = src->qual; + dst->n_info = src->n_info; dst->n_allele = src->n_allele; + dst->n_fmt = src->n_fmt; dst->n_sample = src->n_sample; + + dst->shared.m = dst->shared.l = src->shared.l; + dst->shared.s = (char*) malloc(dst->shared.l); + memcpy(dst->shared.s,src->shared.s,dst->shared.l); + + dst->indiv.m = dst->indiv.l = src->indiv.l; + dst->indiv.s = (char*) malloc(dst->indiv.l); + memcpy(dst->indiv.s,src->indiv.s,dst->indiv.l); + + return dst; +} +bcf1_t *bcf_dup(bcf1_t *src) +{ + bcf1_t *out = bcf_init1(); + return bcf_copy(out, src); +} + +int bcf_write(htsFile *hfp, const bcf_hdr_t *h, bcf1_t *v) +{ + if ( h->dirty ) + { + // we could as well call bcf_hdr_sync here, not sure + fprintf(stderr,"FIXME: dirty header not synced\n"); + exit(1); + } + if ( bcf_hdr_nsamples(h)!=v->n_sample ) + { + fprintf(stderr,"[%s:%d %s] Broken VCF record, the number of columns at %s:%d does not match the number of samples (%d vs %d).\n", + __FILE__,__LINE__,__FUNCTION__,bcf_seqname(h,v),v->pos+1, v->n_sample,bcf_hdr_nsamples(h)); + return -1; + } + + if ( hfp->format.format == vcf || hfp->format.format == text_format ) + return vcf_write(hfp,h,v); + + if ( v->errcode ) + { + // vcf_parse1() encountered a new contig or tag, undeclared in the + // header. At this point, the header must have been printed, + // proceeding would lead to a broken BCF file. Errors must be checked + // and cleared by the caller before we can proceed. + fprintf(stderr,"[%s:%d %s] Unchecked error (%d), exiting.\n", __FILE__,__LINE__,__FUNCTION__,v->errcode); + exit(1); + } + bcf1_sync(v); // check if the BCF record was modified + + BGZF *fp = hfp->fp.bgzf; + uint32_t x[8]; + x[0] = v->shared.l + 24; // to include six 32-bit integers + x[1] = v->indiv.l; + memcpy(x + 2, v, 16); + x[6] = (uint32_t)v->n_allele<<16 | v->n_info; + x[7] = (uint32_t)v->n_fmt<<24 | v->n_sample; + if ( bgzf_write(fp, x, 32) != 32 ) return -1; + if ( bgzf_write(fp, v->shared.s, v->shared.l) != v->shared.l ) return -1; + if ( bgzf_write(fp, v->indiv.s, v->indiv.l) != v->indiv.l ) return -1; + return 0; +} + +/********************** + *** VCF header I/O *** + **********************/ + +bcf_hdr_t *vcf_hdr_read(htsFile *fp) +{ + kstring_t txt, *s = &fp->line; + bcf_hdr_t *h; + h = bcf_hdr_init("r"); + txt.l = txt.m = 0; txt.s = 0; + while (hts_getline(fp, KS_SEP_LINE, s) >= 0) { + if (s->l == 0) continue; + if (s->s[0] != '#') { + if (hts_verbose >= 2) + fprintf(stderr, "[E::%s] no sample line\n", __func__); + free(txt.s); + bcf_hdr_destroy(h); + return 0; + } + if (s->s[1] != '#' && fp->fn_aux) { // insert contigs here + int dret; + gzFile f; + kstream_t *ks; + kstring_t tmp; + tmp.l = tmp.m = 0; tmp.s = 0; + f = gzopen(fp->fn_aux, "r"); + ks = ks_init(f); + while (ks_getuntil(ks, 0, &tmp, &dret) >= 0) { + int c; + kputs("##contig=<ID=", &txt); kputs(tmp.s, &txt); + ks_getuntil(ks, 0, &tmp, &dret); + kputs(",length=", &txt); kputw(atol(tmp.s), &txt); + kputsn(">\n", 2, &txt); + if (dret != '\n') + while ((c = ks_getc(ks)) != '\n' && c != -1); // skip the rest of the line + } + free(tmp.s); + ks_destroy(ks); + gzclose(f); + } + kputsn(s->s, s->l, &txt); + kputc('\n', &txt); + if (s->s[1] != '#') break; + } + if ( !txt.s ) + { + fprintf(stderr,"[%s:%d %s] Could not read the header\n", __FILE__,__LINE__,__FUNCTION__); + return NULL; + } + bcf_hdr_parse(h, txt.s); + + // check tabix index, are all contigs listed in the header? add the missing ones + tbx_t *idx = tbx_index_load(fp->fn); + if ( idx ) + { + int i, n, need_sync = 0; + const char **names = tbx_seqnames(idx, &n); + for (i=0; i<n; i++) + { + bcf_hrec_t *hrec = bcf_hdr_get_hrec(h, BCF_HL_CTG, "ID", (char*) names[i], NULL); + if ( hrec ) continue; + hrec = (bcf_hrec_t*) calloc(1,sizeof(bcf_hrec_t)); + hrec->key = strdup("contig"); + bcf_hrec_add_key(hrec, "ID", strlen("ID")); + bcf_hrec_set_val(hrec, hrec->nkeys-1, (char*) names[i], strlen(names[i]), 0); + bcf_hdr_add_hrec(h, hrec); + need_sync = 1; + } + free(names); + tbx_destroy(idx); + if ( need_sync ) + bcf_hdr_sync(h); + } + free(txt.s); + return h; +} + +int bcf_hdr_set(bcf_hdr_t *hdr, const char *fname) +{ + int i, n; + char **lines = hts_readlines(fname, &n); + if ( !lines ) return 1; + for (i=0; i<n-1; i++) + { + int k; + bcf_hrec_t *hrec = bcf_hdr_parse_line(hdr,lines[i],&k); + if ( hrec ) bcf_hdr_add_hrec(hdr, hrec); + free(lines[i]); + } + bcf_hdr_parse_sample_line(hdr,lines[n-1]); + free(lines[n-1]); + free(lines); + bcf_hdr_sync(hdr); + return 0; +} + +static void _bcf_hrec_format(const bcf_hrec_t *hrec, int is_bcf, kstring_t *str) +{ + if ( !hrec->value ) + { + int j, nout = 0; + ksprintf(str, "##%s=<", hrec->key); + for (j=0; j<hrec->nkeys; j++) + { + // do not output IDX if output is VCF + if ( !is_bcf && !strcmp("IDX",hrec->keys[j]) ) continue; + if ( nout ) kputc(',',str); + ksprintf(str,"%s=%s", hrec->keys[j], hrec->vals[j]); + nout++; + } + ksprintf(str,">\n"); + } + else + ksprintf(str,"##%s=%s\n", hrec->key,hrec->value); +} + +void bcf_hrec_format(const bcf_hrec_t *hrec, kstring_t *str) +{ + _bcf_hrec_format(hrec,0,str); +} +char *bcf_hdr_fmt_text(const bcf_hdr_t *hdr, int is_bcf, int *len) +{ + int i; + kstring_t txt = {0,0,0}; + for (i=0; i<hdr->nhrec; i++) + _bcf_hrec_format(hdr->hrec[i], is_bcf, &txt); + + ksprintf(&txt,"#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO"); + if ( bcf_hdr_nsamples(hdr) ) + { + ksprintf(&txt,"\tFORMAT"); + for (i=0; i<bcf_hdr_nsamples(hdr); i++) + ksprintf(&txt,"\t%s", hdr->samples[i]); + } + ksprintf(&txt,"\n"); + + if ( len ) *len = txt.l; + return txt.s; +} + +const char **bcf_hdr_seqnames(const bcf_hdr_t *h, int *n) +{ + vdict_t *d = (vdict_t*)h->dict[BCF_DT_CTG]; + int tid, m = kh_size(d); + const char **names = (const char**) calloc(m,sizeof(const char*)); + khint_t k; + for (k=kh_begin(d); k<kh_end(d); k++) + { + if ( !kh_exist(d,k) ) continue; + tid = kh_val(d,k).id; + assert( tid<m ); + names[tid] = kh_key(d,k); + } + // sanity check: there should be no gaps + for (tid=0; tid<m; tid++) + assert(names[tid]); + *n = m; + return names; +} + +int vcf_hdr_write(htsFile *fp, const bcf_hdr_t *h) +{ + int hlen; + char *htxt = bcf_hdr_fmt_text(h, 0, &hlen); + while (hlen && htxt[hlen-1] == 0) --hlen; // kill trailing zeros + int ret; + if ( fp->format.compression!=no_compression ) + ret = bgzf_write(fp->fp.bgzf, htxt, hlen); + else + ret = hwrite(fp->fp.hfile, htxt, hlen); + free(htxt); + return ret<0 ? -1 : 0; +} + +/*********************** + *** Typed value I/O *** + ***********************/ + +void bcf_enc_vint(kstring_t *s, int n, int32_t *a, int wsize) +{ + int32_t max = INT32_MIN + 1, min = INT32_MAX; + int i; + if (n == 0) bcf_enc_size(s, 0, BCF_BT_NULL); + else if (n == 1) bcf_enc_int1(s, a[0]); + else { + if (wsize <= 0) wsize = n; + for (i = 0; i < n; ++i) { + if (a[i] == bcf_int32_missing || a[i] == bcf_int32_vector_end ) continue; + if (max < a[i]) max = a[i]; + if (min > a[i]) min = a[i]; + } + if (max <= INT8_MAX && min > bcf_int8_vector_end) { + bcf_enc_size(s, wsize, BCF_BT_INT8); + for (i = 0; i < n; ++i) + if ( a[i]==bcf_int32_vector_end ) kputc(bcf_int8_vector_end, s); + else if ( a[i]==bcf_int32_missing ) kputc(bcf_int8_missing, s); + else kputc(a[i], s); + } else if (max <= INT16_MAX && min > bcf_int16_vector_end) { + bcf_enc_size(s, wsize, BCF_BT_INT16); + for (i = 0; i < n; ++i) + { + int16_t x; + if ( a[i]==bcf_int32_vector_end ) x = bcf_int16_vector_end; + else if ( a[i]==bcf_int32_missing ) x = bcf_int16_missing; + else x = a[i]; + kputsn((char*)&x, 2, s); + } + } else { + bcf_enc_size(s, wsize, BCF_BT_INT32); + for (i = 0; i < n; ++i) { + int32_t x = a[i]; + kputsn((char*)&x, 4, s); + } + } + } +} + +void bcf_enc_vfloat(kstring_t *s, int n, float *a) +{ + bcf_enc_size(s, n, BCF_BT_FLOAT); + kputsn((char*)a, n << 2, s); +} + +void bcf_enc_vchar(kstring_t *s, int l, const char *a) +{ + bcf_enc_size(s, l, BCF_BT_CHAR); + kputsn(a, l, s); +} + +void bcf_fmt_array(kstring_t *s, int n, int type, void *data) +{ + int j = 0; + if (n == 0) { + kputc('.', s); + return; + } + if (type == BCF_BT_CHAR) + { + char *p = (char*)data; + for (j = 0; j < n && *p; ++j, ++p) + { + if ( *p==bcf_str_missing ) kputc('.', s); + else kputc(*p, s); + } + } + else + { + #define BRANCH(type_t, is_missing, is_vector_end, kprint) { \ + type_t *p = (type_t *) data; \ + for (j=0; j<n; j++) \ + { \ + if ( is_vector_end ) break; \ + if ( j ) kputc(',', s); \ + if ( is_missing ) kputc('.', s); \ + else kprint; \ + } \ + } + switch (type) { + case BCF_BT_INT8: BRANCH(int8_t, p[j]==bcf_int8_missing, p[j]==bcf_int8_vector_end, kputw(p[j], s)); break; + case BCF_BT_INT16: BRANCH(int16_t, p[j]==bcf_int16_missing, p[j]==bcf_int16_vector_end, kputw(p[j], s)); break; + case BCF_BT_INT32: BRANCH(int32_t, p[j]==bcf_int32_missing, p[j]==bcf_int32_vector_end, kputw(p[j], s)); break; + case BCF_BT_FLOAT: BRANCH(float, bcf_float_is_missing(p[j]), bcf_float_is_vector_end(p[j]), ksprintf(s, "%g", p[j])); break; + default: fprintf(stderr,"todo: type %d\n", type); exit(1); break; + } + #undef BRANCH + } +} + +uint8_t *bcf_fmt_sized_array(kstring_t *s, uint8_t *ptr) +{ + int x, type; + x = bcf_dec_size(ptr, &ptr, &type); + bcf_fmt_array(s, x, type, ptr); + return ptr + (x << bcf_type_shift[type]); +} + +/******************** + *** VCF site I/O *** + ********************/ + +typedef struct { + int key, max_m, size, offset; + uint32_t is_gt:1, max_g:15, max_l:16; + uint32_t y; + uint8_t *buf; +} fmt_aux_t; + +static inline void align_mem(kstring_t *s) +{ + if (s->l&7) { + uint64_t zero = 0; + int l = ((s->l + 7)>>3<<3) - s->l; + kputsn((char*)&zero, l, s); + } +} + +// p,q is the start and the end of the FORMAT field +int _vcf_parse_format(kstring_t *s, const bcf_hdr_t *h, bcf1_t *v, char *p, char *q) +{ + if ( !bcf_hdr_nsamples(h) ) return 0; + + char *r, *t; + int j, l, m, g; + khint_t k; + ks_tokaux_t aux1; + vdict_t *d = (vdict_t*)h->dict[BCF_DT_ID]; + kstring_t *mem = (kstring_t*)&h->mem; + mem->l = 0; + + // count the number of format fields + for (r = p, v->n_fmt = 1; *r; ++r) + if (*r == ':') ++v->n_fmt; + char *end = s->s + s->l; + if ( q>=end ) + { + fprintf(stderr,"[%s:%d %s] Error: FORMAT column with no sample columns starting at %s:%d\n", __FILE__,__LINE__,__FUNCTION__,s->s,v->pos+1); + return -1; + } + + fmt_aux_t *fmt = (fmt_aux_t*)alloca(v->n_fmt * sizeof(fmt_aux_t)); + // get format information from the dictionary + for (j = 0, t = kstrtok(p, ":", &aux1); t; t = kstrtok(0, 0, &aux1), ++j) { + *(char*)aux1.p = 0; + k = kh_get(vdict, d, t); + if (k == kh_end(d) || kh_val(d, k).info[BCF_HL_FMT] == 15) { + fprintf(stderr, "[W::%s] FORMAT '%s' is not defined in the header, assuming Type=String\n", __func__, t); + kstring_t tmp = {0,0,0}; + int l; + ksprintf(&tmp, "##FORMAT=<ID=%s,Number=1,Type=String,Description=\"Dummy\">", t); + bcf_hrec_t *hrec = bcf_hdr_parse_line(h,tmp.s,&l); + free(tmp.s); + if ( bcf_hdr_add_hrec((bcf_hdr_t*)h, hrec) ) bcf_hdr_sync((bcf_hdr_t*)h); + k = kh_get(vdict, d, t); + v->errcode = BCF_ERR_TAG_UNDEF; + } + fmt[j].max_l = fmt[j].max_m = fmt[j].max_g = 0; + fmt[j].key = kh_val(d, k).id; + fmt[j].is_gt = !strcmp(t, "GT"); + fmt[j].y = h->id[0][fmt[j].key].val->info[BCF_HL_FMT]; + } + // compute max + int n_sample_ori = -1; + r = q + 1; // r: position in the format string + m = l = g = 1, v->n_sample = 0; // m: max vector size, l: max field len, g: max number of alleles + while ( r<end ) + { + // can we skip some samples? + if ( h->keep_samples ) + { + n_sample_ori++; + if ( !bit_array_test(h->keep_samples,n_sample_ori) ) + { + while ( *r!='\t' && r<end ) r++; + if ( *r=='\t' ) { *r = 0; r++; } + continue; + } + } + + // collect fmt stats: max vector size, length, number of alleles + j = 0; // j-th format field + for (;;) + { + if ( *r == '\t' ) *r = 0; + if ( *r == ':' || !*r ) // end of field or end of sample + { + if (fmt[j].max_m < m) fmt[j].max_m = m; + if (fmt[j].max_l < l - 1) fmt[j].max_l = l - 1; + if (fmt[j].is_gt && fmt[j].max_g < g) fmt[j].max_g = g; + l = 0, m = g = 1; + if ( *r==':' ) + { + j++; + if ( j>=v->n_fmt ) + { + fprintf(stderr,"Incorrect number of FORMAT fields at %s:%d\n", h->id[BCF_DT_CTG][v->rid].key,v->pos+1); + exit(1); + } + } + else break; + } + else if ( *r== ',' ) m++; + else if ( fmt[j].is_gt && (*r == '|' || *r == '/') ) g++; + if ( r>=end ) break; + r++; l++; + } + v->n_sample++; + if ( v->n_sample == bcf_hdr_nsamples(h) ) break; + r++; + } + + // allocate memory for arrays + for (j = 0; j < v->n_fmt; ++j) { + fmt_aux_t *f = &fmt[j]; + if ( !f->max_m ) f->max_m = 1; // omitted trailing format field + if ((f->y>>4&0xf) == BCF_HT_STR) { + f->size = f->is_gt? f->max_g << 2 : f->max_l; + } else if ((f->y>>4&0xf) == BCF_HT_REAL || (f->y>>4&0xf) == BCF_HT_INT) { + f->size = f->max_m << 2; + } else + { + fprintf(stderr, "[E::%s] the format type %d currently not supported\n", __func__, f->y>>4&0xf); + abort(); // I do not know how to do with Flag in the genotype fields + } + align_mem(mem); + f->offset = mem->l; + ks_resize(mem, mem->l + v->n_sample * f->size); + mem->l += v->n_sample * f->size; + } + for (j = 0; j < v->n_fmt; ++j) + fmt[j].buf = (uint8_t*)mem->s + fmt[j].offset; + // fill the sample fields; at beginning of the loop, t points to the first char of a format + n_sample_ori = -1; + t = q + 1; m = 0; // m: sample id + while ( t<end ) + { + // can we skip some samples? + if ( h->keep_samples ) + { + n_sample_ori++; + if ( !bit_array_test(h->keep_samples,n_sample_ori) ) + { + while ( *t && t<end ) t++; + t++; + continue; + } + } + if ( m == bcf_hdr_nsamples(h) ) break; + + j = 0; // j-th format field, m-th sample + while ( *t ) + { + fmt_aux_t *z = &fmt[j]; + if ((z->y>>4&0xf) == BCF_HT_STR) { + if (z->is_gt) { // genotypes + int32_t is_phased = 0, *x = (int32_t*)(z->buf + z->size * m); + for (l = 0;; ++t) { + if (*t == '.') ++t, x[l++] = is_phased; + else x[l++] = (strtol(t, &t, 10) + 1) << 1 | is_phased; +#if THOROUGH_SANITY_CHECKS + assert( 0 ); // success of strtol,strtod not checked +#endif + is_phased = (*t == '|'); + if (*t == ':' || *t == 0) break; + } + if ( !l ) x[l++] = 0; // An empty field, insert missing value + for (; l < z->size>>2; ++l) x[l] = bcf_int32_vector_end; + } else { + char *x = (char*)z->buf + z->size * m; + for (r = t, l = 0; *t != ':' && *t; ++t) x[l++] = *t; + for (; l < z->size; ++l) x[l] = 0; + } + } else if ((z->y>>4&0xf) == BCF_HT_INT) { + int32_t *x = (int32_t*)(z->buf + z->size * m); + for (l = 0;; ++t) { + if (*t == '.') x[l++] = bcf_int32_missing, ++t; // ++t to skip "." + else x[l++] = strtol(t, &t, 10); + if (*t == ':' || *t == 0) break; + } + if ( !l ) x[l++] = bcf_int32_missing; + for (; l < z->size>>2; ++l) x[l] = bcf_int32_vector_end; + } else if ((z->y>>4&0xf) == BCF_HT_REAL) { + float *x = (float*)(z->buf + z->size * m); + for (l = 0;; ++t) { + if (*t == '.' && !isdigit(t[1])) bcf_float_set_missing(x[l++]), ++t; // ++t to skip "." + else x[l++] = strtod(t, &t); + if (*t == ':' || *t == 0) break; + } + if ( !l ) bcf_float_set_missing(x[l++]); // An empty field, insert missing value + for (; l < z->size>>2; ++l) bcf_float_set_vector_end(x[l]); + } else abort(); + if (*t == 0) { + for (++j; j < v->n_fmt; ++j) { // fill end-of-vector values + z = &fmt[j]; + if ((z->y>>4&0xf) == BCF_HT_STR) { + if (z->is_gt) { + int32_t *x = (int32_t*)(z->buf + z->size * m); + x[0] = bcf_int32_missing; + for (l = 1; l < z->size>>2; ++l) x[l] = bcf_int32_vector_end; + } else { + char *x = (char*)z->buf + z->size * m; + if ( z->size ) x[0] = '.'; + for (l = 1; l < z->size; ++l) x[l] = 0; + } + } else if ((z->y>>4&0xf) == BCF_HT_INT) { + int32_t *x = (int32_t*)(z->buf + z->size * m); + x[0] = bcf_int32_missing; + for (l = 1; l < z->size>>2; ++l) x[l] = bcf_int32_vector_end; + } else if ((z->y>>4&0xf) == BCF_HT_REAL) { + float *x = (float*)(z->buf + z->size * m); + bcf_float_set_missing(x[0]); + for (l = 1; l < z->size>>2; ++l) bcf_float_set_vector_end(x[l]); + } + } + break; + } + else + { + if (*t == ':') ++j; + t++; + } + } + m++; t++; + } + + // write individual genotype information + kstring_t *str = &v->indiv; + int i; + if (v->n_sample > 0) { + for (i = 0; i < v->n_fmt; ++i) { + fmt_aux_t *z = &fmt[i]; + bcf_enc_int1(str, z->key); + if ((z->y>>4&0xf) == BCF_HT_STR && !z->is_gt) { + bcf_enc_size(str, z->size, BCF_BT_CHAR); + kputsn((char*)z->buf, z->size * v->n_sample, str); + } else if ((z->y>>4&0xf) == BCF_HT_INT || z->is_gt) { + bcf_enc_vint(str, (z->size>>2) * v->n_sample, (int32_t*)z->buf, z->size>>2); + } else { + bcf_enc_size(str, z->size>>2, BCF_BT_FLOAT); + kputsn((char*)z->buf, z->size * v->n_sample, str); + } + } + } + + if ( v->n_sample!=bcf_hdr_nsamples(h) ) + { + fprintf(stderr,"[%s:%d %s] Number of columns at %s:%d does not match the number of samples (%d vs %d).\n", + __FILE__,__LINE__,__FUNCTION__,bcf_seqname(h,v),v->pos+1, v->n_sample,bcf_hdr_nsamples(h)); + v->errcode |= BCF_ERR_NCOLS; + return -1; + } + + return 0; +} + +int vcf_parse(kstring_t *s, const bcf_hdr_t *h, bcf1_t *v) +{ + int i = 0; + char *p, *q, *r, *t; + kstring_t *str; + khint_t k; + ks_tokaux_t aux; + + bcf_clear1(v); + str = &v->shared; + memset(&aux, 0, sizeof(ks_tokaux_t)); + for (p = kstrtok(s->s, "\t", &aux), i = 0; p; p = kstrtok(0, 0, &aux), ++i) { + q = (char*)aux.p; + *q = 0; + if (i == 0) { // CHROM + vdict_t *d = (vdict_t*)h->dict[BCF_DT_CTG]; + k = kh_get(vdict, d, p); + if (k == kh_end(d)) + { + // Simple error recovery for chromosomes not defined in the header. It will not help when VCF header has + // been already printed, but will enable tools like vcfcheck to proceed. + fprintf(stderr, "[W::%s] contig '%s' is not defined in the header. (Quick workaround: index the file with tabix.)\n", __func__, p); + kstring_t tmp = {0,0,0}; + int l; + ksprintf(&tmp, "##contig=<ID=%s>", p); + bcf_hrec_t *hrec = bcf_hdr_parse_line(h,tmp.s,&l); + free(tmp.s); + if ( bcf_hdr_add_hrec((bcf_hdr_t*)h, hrec) ) bcf_hdr_sync((bcf_hdr_t*)h); + k = kh_get(vdict, d, p); + v->errcode = BCF_ERR_CTG_UNDEF; + } + v->rid = kh_val(d, k).id; + } else if (i == 1) { // POS + v->pos = atoi(p) - 1; + } else if (i == 2) { // ID + if (strcmp(p, ".")) bcf_enc_vchar(str, q - p, p); + else bcf_enc_size(str, 0, BCF_BT_CHAR); + } else if (i == 3) { // REF + bcf_enc_vchar(str, q - p, p); + v->n_allele = 1, v->rlen = q - p; + } else if (i == 4) { // ALT + if (strcmp(p, ".")) { + for (r = t = p;; ++r) { + if (*r == ',' || *r == 0) { + bcf_enc_vchar(str, r - t, t); + t = r + 1; + ++v->n_allele; + } + if (r == q) break; + } + } + } else if (i == 5) { // QUAL + if (strcmp(p, ".")) v->qual = atof(p); + else memcpy(&v->qual, &bcf_float_missing, 4); + if ( v->max_unpack && !(v->max_unpack>>1) ) return 0; // BCF_UN_STR + } else if (i == 6) { // FILTER + if (strcmp(p, ".")) { + int32_t *a; + int n_flt = 1, i; + ks_tokaux_t aux1; + vdict_t *d = (vdict_t*)h->dict[BCF_DT_ID]; + // count the number of filters + if (*(q-1) == ';') *(q-1) = 0; + for (r = p; *r; ++r) + if (*r == ';') ++n_flt; + a = (int32_t*)alloca(n_flt * sizeof(int32_t)); + // add filters + for (t = kstrtok(p, ";", &aux1), i = 0; t; t = kstrtok(0, 0, &aux1)) { + *(char*)aux1.p = 0; + k = kh_get(vdict, d, t); + if (k == kh_end(d)) + { + // Simple error recovery for FILTERs not defined in the header. It will not help when VCF header has + // been already printed, but will enable tools like vcfcheck to proceed. + fprintf(stderr, "[W::%s] FILTER '%s' is not defined in the header\n", __func__, t); + kstring_t tmp = {0,0,0}; + int l; + ksprintf(&tmp, "##FILTER=<ID=%s,Description=\"Dummy\">", t); + bcf_hrec_t *hrec = bcf_hdr_parse_line(h,tmp.s,&l); + free(tmp.s); + if ( bcf_hdr_add_hrec((bcf_hdr_t*)h, hrec) ) bcf_hdr_sync((bcf_hdr_t*)h); + k = kh_get(vdict, d, t); + v->errcode = BCF_ERR_TAG_UNDEF; + } + a[i++] = kh_val(d, k).id; + } + n_flt = i; + bcf_enc_vint(str, n_flt, a, -1); + } else bcf_enc_vint(str, 0, 0, -1); + if ( v->max_unpack && !(v->max_unpack>>2) ) return 0; // BCF_UN_FLT + } else if (i == 7) { // INFO + char *key; + vdict_t *d = (vdict_t*)h->dict[BCF_DT_ID]; + v->n_info = 0; + if (strcmp(p, ".")) { + if (*(q-1) == ';') *(q-1) = 0; + for (r = key = p;; ++r) { + int c; + char *val, *end; + if (*r != ';' && *r != '=' && *r != 0) continue; + val = end = 0; + c = *r; *r = 0; + if (c == '=') { + val = r + 1; + for (end = val; *end != ';' && *end != 0; ++end); + c = *end; *end = 0; + } else end = r; + if ( !*key ) { if (c==0) break; r = end; key = r + 1; continue; } // faulty VCF, ";;" in the INFO + k = kh_get(vdict, d, key); + if (k == kh_end(d) || kh_val(d, k).info[BCF_HL_INFO] == 15) + { + fprintf(stderr, "[W::%s] INFO '%s' is not defined in the header, assuming Type=String\n", __func__, key); + kstring_t tmp = {0,0,0}; + int l; + ksprintf(&tmp, "##INFO=<ID=%s,Number=1,Type=String,Description=\"Dummy\">", key); + bcf_hrec_t *hrec = bcf_hdr_parse_line(h,tmp.s,&l); + free(tmp.s); + if ( bcf_hdr_add_hrec((bcf_hdr_t*)h, hrec) ) bcf_hdr_sync((bcf_hdr_t*)h); + k = kh_get(vdict, d, key); + v->errcode = BCF_ERR_TAG_UNDEF; + } + uint32_t y = kh_val(d, k).info[BCF_HL_INFO]; + ++v->n_info; + bcf_enc_int1(str, kh_val(d, k).id); + if (val == 0) { + bcf_enc_size(str, 0, BCF_BT_NULL); + } else if ((y>>4&0xf) == BCF_HT_FLAG || (y>>4&0xf) == BCF_HT_STR) { // if Flag has a value, treat it as a string + bcf_enc_vchar(str, end - val, val); + } else { // int/float value/array + int i, n_val; + char *t, *te; + for (t = val, n_val = 1; *t; ++t) // count the number of values + if (*t == ',') ++n_val; + if ((y>>4&0xf) == BCF_HT_INT) { + int32_t *z; + z = (int32_t*)alloca(n_val * sizeof(int32_t)); + for (i = 0, t = val; i < n_val; ++i, ++t) + { + z[i] = strtol(t, &te, 10); + if ( te==t ) // conversion failed + { + z[i] = bcf_int32_missing; + while ( *te && *te!=',' ) te++; + } + t = te; + } + bcf_enc_vint(str, n_val, z, -1); + if (strcmp(key, "END") == 0) v->rlen = z[0] - v->pos; + } else if ((y>>4&0xf) == BCF_HT_REAL) { + float *z; + z = (float*)alloca(n_val * sizeof(float)); + for (i = 0, t = val; i < n_val; ++i, ++t) + { + z[i] = strtod(t, &te); + if ( te==t ) // conversion failed + { + bcf_float_set_missing(z[i]); + while ( *te && *te!=',' ) te++; + } + t = te; + } + bcf_enc_vfloat(str, n_val, z); + } + } + if (c == 0) break; + r = end; + key = r + 1; + } + } + if ( v->max_unpack && !(v->max_unpack>>3) ) return 0; + } else if (i == 8) // FORMAT + return _vcf_parse_format(s, h, v, p, q); + } + return 0; +} + +int vcf_read(htsFile *fp, const bcf_hdr_t *h, bcf1_t *v) +{ + int ret; + ret = hts_getline(fp, KS_SEP_LINE, &fp->line); + if (ret < 0) return -1; + return vcf_parse1(&fp->line, h, v); +} + +static inline uint8_t *bcf_unpack_fmt_core1(uint8_t *ptr, int n_sample, bcf_fmt_t *fmt) +{ + uint8_t *ptr_start = ptr; + fmt->id = bcf_dec_typed_int1(ptr, &ptr); + fmt->n = bcf_dec_size(ptr, &ptr, &fmt->type); + fmt->size = fmt->n << bcf_type_shift[fmt->type]; + fmt->p = ptr; + fmt->p_off = ptr - ptr_start; + fmt->p_free = 0; + ptr += n_sample * fmt->size; + fmt->p_len = ptr - fmt->p; + return ptr; +} + +static inline uint8_t *bcf_unpack_info_core1(uint8_t *ptr, bcf_info_t *info) +{ + uint8_t *ptr_start = ptr; + info->key = bcf_dec_typed_int1(ptr, &ptr); + info->len = bcf_dec_size(ptr, &ptr, &info->type); + info->vptr = ptr; + info->vptr_off = ptr - ptr_start; + info->vptr_free = 0; + info->v1.i = 0; + if (info->len == 1) { + if (info->type == BCF_BT_INT8 || info->type == BCF_BT_CHAR) info->v1.i = *(int8_t*)ptr; + else if (info->type == BCF_BT_INT32) info->v1.i = *(int32_t*)ptr; + else if (info->type == BCF_BT_FLOAT) info->v1.f = *(float*)ptr; + else if (info->type == BCF_BT_INT16) info->v1.i = *(int16_t*)ptr; + } + ptr += info->len << bcf_type_shift[info->type]; + info->vptr_len = ptr - info->vptr; + return ptr; +} + +int bcf_unpack(bcf1_t *b, int which) +{ + if ( !b->shared.l ) return 0; // Building a new BCF record from scratch + uint8_t *ptr = (uint8_t*)b->shared.s, *ptr_ori; + int *offset, i; + bcf_dec_t *d = &b->d; + if (which & BCF_UN_FLT) which |= BCF_UN_STR; + if (which & BCF_UN_INFO) which |= BCF_UN_SHR; + if ((which&BCF_UN_STR) && !(b->unpacked&BCF_UN_STR)) + { + kstring_t tmp; + + // ID + tmp.l = 0; tmp.s = d->id; tmp.m = d->m_id; + ptr_ori = ptr; + ptr = bcf_fmt_sized_array(&tmp, ptr); + b->unpack_size[0] = ptr - ptr_ori; + kputc('\0', &tmp); + d->id = tmp.s; d->m_id = tmp.m; + + // REF and ALT are in a single block (d->als) and d->alleles are pointers into this block + tmp.l = 0; tmp.s = d->als; tmp.m = d->m_als; + offset = (int*)alloca(b->n_allele * sizeof(int)); + ptr_ori = ptr; + for (i = 0; i < b->n_allele; ++i) { + offset[i] = tmp.l; + ptr = bcf_fmt_sized_array(&tmp, ptr); + kputc('\0', &tmp); + } + b->unpack_size[1] = ptr - ptr_ori; + d->als = tmp.s; d->m_als = tmp.m; + + hts_expand(char*, b->n_allele, d->m_allele, d->allele); // NM: hts_expand() is a macro + for (i = 0; i < b->n_allele; ++i) + d->allele[i] = d->als + offset[i]; + b->unpacked |= BCF_UN_STR; + } + if ((which&BCF_UN_FLT) && !(b->unpacked&BCF_UN_FLT)) { // FILTER + ptr = (uint8_t*)b->shared.s + b->unpack_size[0] + b->unpack_size[1]; + ptr_ori = ptr; + if (*ptr>>4) { + int type; + d->n_flt = bcf_dec_size(ptr, &ptr, &type); + hts_expand(int, d->n_flt, d->m_flt, d->flt); + for (i = 0; i < d->n_flt; ++i) + d->flt[i] = bcf_dec_int1(ptr, type, &ptr); + } else ++ptr, d->n_flt = 0; + b->unpack_size[2] = ptr - ptr_ori; + b->unpacked |= BCF_UN_FLT; + } + if ((which&BCF_UN_INFO) && !(b->unpacked&BCF_UN_INFO)) { // INFO + ptr = (uint8_t*)b->shared.s + b->unpack_size[0] + b->unpack_size[1] + b->unpack_size[2]; + hts_expand(bcf_info_t, b->n_info, d->m_info, d->info); + for (i = 0; i < d->m_info; ++i) d->info[i].vptr_free = 0; + for (i = 0; i < b->n_info; ++i) + ptr = bcf_unpack_info_core1(ptr, &d->info[i]); + b->unpacked |= BCF_UN_INFO; + } + if ((which&BCF_UN_FMT) && b->n_sample && !(b->unpacked&BCF_UN_FMT)) { // FORMAT + ptr = (uint8_t*)b->indiv.s; + hts_expand(bcf_fmt_t, b->n_fmt, d->m_fmt, d->fmt); + for (i = 0; i < d->m_fmt; ++i) d->fmt[i].p_free = 0; + for (i = 0; i < b->n_fmt; ++i) + ptr = bcf_unpack_fmt_core1(ptr, b->n_sample, &d->fmt[i]); + b->unpacked |= BCF_UN_FMT; + } + return 0; +} + +int vcf_format(const bcf_hdr_t *h, const bcf1_t *v, kstring_t *s) +{ + int i; + bcf_unpack((bcf1_t*)v, BCF_UN_ALL); + kputs(h->id[BCF_DT_CTG][v->rid].key, s); // CHROM + kputc('\t', s); kputw(v->pos + 1, s); // POS + kputc('\t', s); kputs(v->d.id ? v->d.id : ".", s); // ID + kputc('\t', s); // REF + if (v->n_allele > 0) kputs(v->d.allele[0], s); + else kputc('.', s); + kputc('\t', s); // ALT + if (v->n_allele > 1) { + for (i = 1; i < v->n_allele; ++i) { + if (i > 1) kputc(',', s); + kputs(v->d.allele[i], s); + } + } else kputc('.', s); + kputc('\t', s); // QUAL + if ( bcf_float_is_missing(v->qual) ) kputc('.', s); // QUAL + else ksprintf(s, "%g", v->qual); + kputc('\t', s); // FILTER + if (v->d.n_flt) { + for (i = 0; i < v->d.n_flt; ++i) { + if (i) kputc(';', s); + kputs(h->id[BCF_DT_ID][v->d.flt[i]].key, s); + } + } else kputc('.', s); + kputc('\t', s); // INFO + if (v->n_info) { + int first = 1; + for (i = 0; i < v->n_info; ++i) { + bcf_info_t *z = &v->d.info[i]; + if ( !z->vptr ) continue; + if ( !first ) kputc(';', s); first = 0; + kputs(h->id[BCF_DT_ID][z->key].key, s); + if (z->len <= 0) continue; + kputc('=', s); + if (z->len == 1) + { + switch (z->type) + { + case BCF_BT_INT8: if ( z->v1.i==bcf_int8_missing ) kputc('.', s); else kputw(z->v1.i, s); break; + case BCF_BT_INT16: if ( z->v1.i==bcf_int16_missing ) kputc('.', s); else kputw(z->v1.i, s); break; + case BCF_BT_INT32: if ( z->v1.i==bcf_int32_missing ) kputc('.', s); else kputw(z->v1.i, s); break; + case BCF_BT_FLOAT: if ( bcf_float_is_missing(z->v1.f) ) kputc('.', s); else ksprintf(s, "%g", z->v1.f); break; + case BCF_BT_CHAR: kputc(z->v1.i, s); break; + default: fprintf(stderr,"todo: type %d\n", z->type); exit(1); break; + } + } + else bcf_fmt_array(s, z->len, z->type, z->vptr); + } + if ( first ) kputc('.', s); + } else kputc('.', s); + // FORMAT and individual information + if (v->n_sample) + { + int i,j; + if ( v->n_fmt) + { + int gt_i = -1; + bcf_fmt_t *fmt = v->d.fmt; + int first = 1; + for (i = 0; i < (int)v->n_fmt; ++i) { + if ( !fmt[i].p ) continue; + kputc(!first ? ':' : '\t', s); first = 0; + if ( fmt[i].id<0 ) //!bcf_hdr_idinfo_exists(h,BCF_HL_FMT,fmt[i].id) ) + { + fprintf(stderr, "[E::%s] invalid BCF, the FORMAT tag id=%d not present in the header.\n", __func__, fmt[i].id); + abort(); + } + kputs(h->id[BCF_DT_ID][fmt[i].id].key, s); + if (strcmp(h->id[BCF_DT_ID][fmt[i].id].key, "GT") == 0) gt_i = i; + } + if ( first ) kputs("\t.", s); + for (j = 0; j < v->n_sample; ++j) { + kputc('\t', s); + first = 1; + for (i = 0; i < (int)v->n_fmt; ++i) { + bcf_fmt_t *f = &fmt[i]; + if ( !f->p ) continue; + if (!first) kputc(':', s); first = 0; + if (gt_i == i) + bcf_format_gt(f,j,s); + else + bcf_fmt_array(s, f->n, f->type, f->p + j * f->size); + } + if ( first ) kputc('.', s); + } + } + else + for (j=0; j<=v->n_sample; j++) + kputs("\t.", s); + } + kputc('\n', s); + return 0; +} + +int vcf_write_line(htsFile *fp, kstring_t *line) +{ + int ret; + if ( line->s[line->l-1]!='\n' ) kputc('\n',line); + if ( fp->format.compression!=no_compression ) + ret = bgzf_write(fp->fp.bgzf, line->s, line->l); + else + ret = hwrite(fp->fp.hfile, line->s, line->l); + return ret==line->l ? 0 : -1; +} + +int vcf_write(htsFile *fp, const bcf_hdr_t *h, bcf1_t *v) +{ + int ret; + fp->line.l = 0; + vcf_format1(h, v, &fp->line); + if ( fp->format.compression!=no_compression ) + ret = bgzf_write(fp->fp.bgzf, fp->line.s, fp->line.l); + else + ret = hwrite(fp->fp.hfile, fp->line.s, fp->line.l); + return ret==fp->line.l ? 0 : -1; +} + +/************************ + * Data access routines * + ************************/ + +int bcf_hdr_id2int(const bcf_hdr_t *h, int which, const char *id) +{ + khint_t k; + vdict_t *d = (vdict_t*)h->dict[which]; + k = kh_get(vdict, d, id); + return k == kh_end(d)? -1 : kh_val(d, k).id; +} + + +/******************** + *** BCF indexing *** + ********************/ + +hts_idx_t *bcf_index(htsFile *fp, int min_shift) +{ + int n_lvls, i; + bcf1_t *b; + hts_idx_t *idx; + bcf_hdr_t *h; + int64_t max_len = 0, s; + h = bcf_hdr_read(fp); + if ( !h ) return NULL; + int nids = 0; + for (i = 0; i < h->n[BCF_DT_CTG]; ++i) + { + if ( !h->id[BCF_DT_CTG][i].val ) continue; + if ( max_len < h->id[BCF_DT_CTG][i].val->info[0] ) max_len = h->id[BCF_DT_CTG][i].val->info[0]; + nids++; + } + if ( !max_len ) max_len = ((int64_t)1<<31) - 1; // In case contig line is broken. + max_len += 256; + for (n_lvls = 0, s = 1<<min_shift; max_len > s; ++n_lvls, s <<= 3); + idx = hts_idx_init(nids, HTS_FMT_CSI, bgzf_tell(fp->fp.bgzf), min_shift, n_lvls); + b = bcf_init1(); + while (bcf_read1(fp,h, b) >= 0) { + int ret; + ret = hts_idx_push(idx, b->rid, b->pos, b->pos + b->rlen, bgzf_tell(fp->fp.bgzf), 1); + if (ret < 0) + { + bcf_destroy1(b); + hts_idx_destroy(idx); + return NULL; + } + } + hts_idx_finish(idx, bgzf_tell(fp->fp.bgzf)); + bcf_destroy1(b); + bcf_hdr_destroy(h); + return idx; +} + +int bcf_index_build(const char *fn, int min_shift) +{ + htsFile *fp; + hts_idx_t *idx; + if ((fp = hts_open(fn, "rb")) == 0) return -1; + if ( fp->format.compression!=bgzf ) { hts_close(fp); return -1; } + idx = bcf_index(fp, min_shift); + hts_close(fp); + if ( !idx ) return -1; + hts_idx_save(idx, fn, HTS_FMT_CSI); + hts_idx_destroy(idx); + return 0; +} + +/***************** + *** Utilities *** + *****************/ + +int bcf_hdr_combine(bcf_hdr_t *dst, const bcf_hdr_t *src) +{ + int i, ndst_ori = dst->nhrec, need_sync = 0, ret = 0; + for (i=0; i<src->nhrec; i++) + { + if ( src->hrec[i]->type==BCF_HL_GEN && src->hrec[i]->value ) + { + int j; + for (j=0; j<ndst_ori; j++) + { + if ( dst->hrec[j]->type!=BCF_HL_GEN ) continue; + + // Checking only the key part of generic lines, otherwise + // the VCFs are too verbose. Should we perhaps add a flag + // to bcf_hdr_combine() and make this optional? + if ( !strcmp(src->hrec[i]->key,dst->hrec[j]->key) ) break; + } + if ( j>=ndst_ori ) + need_sync += bcf_hdr_add_hrec(dst, bcf_hrec_dup(src->hrec[i])); + } + else if ( src->hrec[i]->type==BCF_HL_STR ) + { + // NB: we are ignoring fields without ID + int j = bcf_hrec_find_key(src->hrec[i],"ID"); + if ( j>=0 ) + { + bcf_hrec_t *rec = bcf_hdr_get_hrec(dst, src->hrec[i]->type, "ID", src->hrec[i]->vals[j], src->hrec[i]->key); + if ( !rec ) + need_sync += bcf_hdr_add_hrec(dst, bcf_hrec_dup(src->hrec[i])); + } + } + else + { + int j = bcf_hrec_find_key(src->hrec[i],"ID"); + assert( j>=0 ); // this should always be true for valid VCFs + + bcf_hrec_t *rec = bcf_hdr_get_hrec(dst, src->hrec[i]->type, "ID", src->hrec[i]->vals[j], NULL); + if ( !rec ) + need_sync += bcf_hdr_add_hrec(dst, bcf_hrec_dup(src->hrec[i])); + else if ( src->hrec[i]->type==BCF_HL_INFO || src->hrec[i]->type==BCF_HL_FMT ) + { + // Check that both records are of the same type. The bcf_hdr_id2length + // macro cannot be used here because dst header is not synced yet. + vdict_t *d_src = (vdict_t*)src->dict[BCF_DT_ID]; + vdict_t *d_dst = (vdict_t*)dst->dict[BCF_DT_ID]; + khint_t k_src = kh_get(vdict, d_src, src->hrec[i]->vals[0]); + khint_t k_dst = kh_get(vdict, d_dst, src->hrec[i]->vals[0]); + if ( (kh_val(d_src,k_src).info[rec->type]>>8 & 0xf) != (kh_val(d_dst,k_dst).info[rec->type]>>8 & 0xf) ) + { + fprintf(stderr,"Warning: trying to combine \"%s\" tag definitions of different lengths\n", src->hrec[i]->vals[0]); + ret |= 1; + } + if ( (kh_val(d_src,k_src).info[rec->type]>>4 & 0xf) != (kh_val(d_dst,k_dst).info[rec->type]>>4 & 0xf) ) + { + fprintf(stderr,"Warning: trying to combine \"%s\" tag definitions of different types\n", src->hrec[i]->vals[0]); + ret |= 1; + } + } + } + } + if ( need_sync ) bcf_hdr_sync(dst); + return ret; +} +int bcf_translate(const bcf_hdr_t *dst_hdr, bcf_hdr_t *src_hdr, bcf1_t *line) +{ + int i; + if ( line->errcode ) + { + fprintf(stderr,"[%s:%d %s] Unchecked error (%d), exiting.\n", __FILE__,__LINE__,__FUNCTION__,line->errcode); + exit(1); + } + if ( src_hdr->ntransl==-1 ) return 0; // no need to translate, all tags have the same id + if ( !src_hdr->ntransl ) // called for the first time, see what needs translating + { + int dict; + for (dict=0; dict<2; dict++) // BCF_DT_ID and BCF_DT_CTG + { + src_hdr->transl[dict] = (int*) malloc(src_hdr->n[dict]*sizeof(int)); + for (i=0; i<src_hdr->n[dict]; i++) + { + if ( !src_hdr->id[dict][i].key || !dst_hdr->id[dict][i].key ) // gap left after removed BCF header lines + src_hdr->transl[dict][i] = -1; + else if ( i>=dst_hdr->n[dict] || strcmp(src_hdr->id[dict][i].key,dst_hdr->id[dict][i].key) ) + { + src_hdr->transl[dict][i] = bcf_hdr_id2int(dst_hdr,dict,src_hdr->id[dict][i].key); + src_hdr->ntransl++; + } + else + src_hdr->transl[dict][i] = -1; + } + } + if ( !src_hdr->ntransl ) + { + free(src_hdr->transl[0]); src_hdr->transl[0] = NULL; + free(src_hdr->transl[1]); src_hdr->transl[1] = NULL; + src_hdr->ntransl = -1; + } + if ( src_hdr->ntransl==-1 ) return 0; + } + bcf_unpack(line,BCF_UN_ALL); + + // CHROM + if ( src_hdr->transl[BCF_DT_CTG][line->rid] >=0 ) line->rid = src_hdr->transl[BCF_DT_CTG][line->rid]; + + // FILTER + for (i=0; i<line->d.n_flt; i++) + { + int src_id = line->d.flt[i]; + if ( src_hdr->transl[BCF_DT_ID][src_id] >=0 ) + line->d.flt[i] = src_hdr->transl[BCF_DT_ID][src_id]; + line->d.shared_dirty |= BCF1_DIRTY_FLT; + } + + // INFO + for (i=0; i<line->n_info; i++) + { + int src_id = line->d.info[i].key; + int dst_id = src_hdr->transl[BCF_DT_ID][src_id]; + if ( dst_id<0 ) continue; + int src_size = src_id>>7 ? ( src_id>>15 ? BCF_BT_INT32 : BCF_BT_INT16) : BCF_BT_INT8; + int dst_size = dst_id>>7 ? ( dst_id>>15 ? BCF_BT_INT32 : BCF_BT_INT16) : BCF_BT_INT8; + if ( src_size==dst_size ) // can overwrite + { + line->d.info[i].key = dst_id; + uint8_t *vptr = line->d.info[i].vptr - line->d.info[i].vptr_off; + if ( dst_size==BCF_BT_INT8 ) { vptr[1] = (uint8_t)dst_id; } + else if ( dst_size==BCF_BT_INT16 ) { *(uint16_t*)vptr = (uint16_t)dst_id; } + else { *(uint32_t*)vptr = (uint32_t)dst_id; } + } + else // must realloc + { + bcf_info_t *info = &line->d.info[i]; + assert( !info->vptr_free ); + kstring_t str = {0,0,0}; + bcf_enc_int1(&str, dst_id); + bcf_enc_size(&str, info->len,info->type); + info->vptr_off = str.l; + kputsn((char*)info->vptr, info->vptr_len, &str); + info->vptr = (uint8_t*)str.s + info->vptr_off; + info->vptr_free = 1; + info->key = dst_id; + line->d.shared_dirty |= BCF1_DIRTY_INF; + } + } + + // FORMAT + for (i=0; i<line->n_fmt; i++) + { + int src_id = line->d.fmt[i].id; + int dst_id = src_hdr->transl[BCF_DT_ID][src_id]; + if ( dst_id<0 ) continue; + int src_size = src_id>>7 ? ( src_id>>15 ? BCF_BT_INT32 : BCF_BT_INT16) : BCF_BT_INT8; + int dst_size = dst_id>>7 ? ( dst_id>>15 ? BCF_BT_INT32 : BCF_BT_INT16) : BCF_BT_INT8; + if ( src_size==dst_size ) // can overwrite + { + line->d.fmt[i].id = dst_id; + uint8_t *p = line->d.fmt[i].p - line->d.fmt[i].p_off; // pointer to the vector size (4bits) and BT type (4bits) + if ( dst_size==BCF_BT_INT8 ) { p[1] = dst_id; } + else if ( dst_size==BCF_BT_INT16 ) { uint8_t *x = (uint8_t*) &dst_id; p[1] = x[0]; p[2] = x[1]; } + else { uint8_t *x = (uint8_t*) &dst_id; p[1] = x[0]; p[2] = x[1]; p[3] = x[2]; p[4] = x[3]; } + } + else // must realloc + { + bcf_fmt_t *fmt = &line->d.fmt[i]; + assert( !fmt->p_free ); + kstring_t str = {0,0,0}; + bcf_enc_int1(&str, dst_id); + bcf_enc_size(&str, fmt->n, fmt->type); + fmt->p_off = str.l; + kputsn((char*)fmt->p, fmt->p_len, &str); + fmt->p = (uint8_t*)str.s + fmt->p_off; + fmt->p_free = 1; + fmt->id = dst_id; + line->d.indiv_dirty = 1; + } + } + return 0; +} + +bcf_hdr_t *bcf_hdr_dup(const bcf_hdr_t *hdr) +{ + bcf_hdr_t *hout = bcf_hdr_init("r"); + char *htxt = bcf_hdr_fmt_text(hdr, 1, NULL); + bcf_hdr_parse(hout, htxt); + free(htxt); + return hout; +} + +bcf_hdr_t *bcf_hdr_subset(const bcf_hdr_t *h0, int n, char *const* samples, int *imap) +{ + int hlen; + void *names_hash = khash_str2int_init(); + char *htxt = bcf_hdr_fmt_text(h0, 1, &hlen); + kstring_t str; + bcf_hdr_t *h; + str.l = str.m = 0; str.s = 0; + h = bcf_hdr_init("w"); + bcf_hdr_set_version(h,bcf_hdr_get_version(h0)); + int j; + for (j=0; j<n; j++) imap[j] = -1; + if ( bcf_hdr_nsamples(h0) > 0) { + char *p; + int i = 0, end = n? 8 : 7; + while ((p = strstr(htxt, "#CHROM\t")) != 0) + if (p > htxt && *(p-1) == '\n') break; + while ((p = strchr(p, '\t')) != 0 && i < end) ++i, ++p; + if (i != end) { + free(h); free(str.s); + return 0; // malformated header + } + kputsn(htxt, p - htxt, &str); + for (i = 0; i < n; ++i) { + if ( khash_str2int_has_key(names_hash,samples[i]) ) + { + fprintf(stderr,"[E::bcf_hdr_subset] Duplicate sample name \"%s\".\n", samples[i]); + free(str.s); + free(htxt); + khash_str2int_destroy(names_hash); + bcf_hdr_destroy(h); + return NULL; + } + imap[i] = bcf_hdr_id2int(h0, BCF_DT_SAMPLE, samples[i]); + if (imap[i] < 0) continue; + kputc('\t', &str); + kputs(samples[i], &str); + khash_str2int_inc(names_hash,samples[i]); + } + } else kputsn(htxt, hlen, &str); + while (str.l && (!str.s[str.l-1] || str.s[str.l-1]=='\n') ) str.l--; // kill trailing zeros and newlines + kputc('\n',&str); + bcf_hdr_parse(h, str.s); + free(str.s); + free(htxt); + khash_str2int_destroy(names_hash); + return h; +} + +int bcf_hdr_set_samples(bcf_hdr_t *hdr, const char *samples, int is_file) +{ + if ( samples && !strcmp("-",samples) ) return 0; // keep all samples + + hdr->nsamples_ori = bcf_hdr_nsamples(hdr); + if ( !samples ) { bcf_hdr_nsamples(hdr) = 0; return 0; } // exclude all samples + + int i, narr = bit_array_size(bcf_hdr_nsamples(hdr)); + hdr->keep_samples = (uint8_t*) calloc(narr,1); + if ( samples[0]=='^' ) + for (i=0; i<bcf_hdr_nsamples(hdr); i++) bit_array_set(hdr->keep_samples,i); + + int idx, n, ret = 0; + char **smpls = hts_readlist(samples[0]=='^'?samples+1:samples, is_file, &n); + if ( !smpls ) return -1; + for (i=0; i<n; i++) + { + idx = bcf_hdr_id2int(hdr,BCF_DT_SAMPLE,smpls[i]); + if ( idx<0 ) + { + if ( !ret ) ret = i+1; + continue; + } + assert( idx<bcf_hdr_nsamples(hdr) ); + if ( samples[0]=='^' ) + bit_array_clear(hdr->keep_samples, idx); + else + bit_array_set(hdr->keep_samples, idx); + } + for (i=0; i<n; i++) free(smpls[i]); + free(smpls); + + bcf_hdr_nsamples(hdr) = 0; + for (i=0; i<hdr->nsamples_ori; i++) + if ( bit_array_test(hdr->keep_samples,i) ) bcf_hdr_nsamples(hdr)++; + if ( !bcf_hdr_nsamples(hdr) ) { free(hdr->keep_samples); hdr->keep_samples=NULL; } + else + { + char **samples = (char**) malloc(sizeof(char*)*bcf_hdr_nsamples(hdr)); + idx = 0; + for (i=0; i<hdr->nsamples_ori; i++) + if ( bit_array_test(hdr->keep_samples,i) ) samples[idx++] = strdup(hdr->samples[i]); + free(hdr->samples); + hdr->samples = samples; + + // delete original samples from the dictionary + vdict_t *d = (vdict_t*)hdr->dict[BCF_DT_SAMPLE]; + int k; + for (k = kh_begin(d); k != kh_end(d); ++k) + if (kh_exist(d, k)) free((char*)kh_key(d, k)); + kh_destroy(vdict, d); + + // add the subset back + hdr->dict[BCF_DT_SAMPLE] = d = kh_init(vdict); + for (i=0; i<bcf_hdr_nsamples(hdr); i++) + { + int ignore, k = kh_put(vdict, d, hdr->samples[i], &ignore); + kh_val(d, k) = bcf_idinfo_def; + kh_val(d, k).id = kh_size(d) - 1; + } + bcf_hdr_sync(hdr); + } + + return ret; +} + +int bcf_subset(const bcf_hdr_t *h, bcf1_t *v, int n, int *imap) +{ + kstring_t ind; + ind.s = 0; ind.l = ind.m = 0; + if (n) { + bcf_fmt_t *fmt; + int i, j; + fmt = (bcf_fmt_t*)alloca(v->n_fmt * sizeof(bcf_fmt_t)); + uint8_t *ptr = (uint8_t*)v->indiv.s; + for (i = 0; i < v->n_fmt; ++i) + ptr = bcf_unpack_fmt_core1(ptr, v->n_sample, &fmt[i]); + for (i = 0; i < (int)v->n_fmt; ++i) { + bcf_fmt_t *f = &fmt[i]; + bcf_enc_int1(&ind, f->id); + bcf_enc_size(&ind, f->n, f->type); + for (j = 0; j < n; ++j) + if (imap[j] >= 0) kputsn((char*)(f->p + imap[j] * f->size), f->size, &ind); + } + for (i = j = 0; j < n; ++j) if (imap[j] >= 0) ++i; + v->n_sample = i; + } else v->n_sample = 0; + if ( !v->n_sample ) v->n_fmt = 0; + free(v->indiv.s); + v->indiv = ind; + v->unpacked &= ~BCF_UN_FMT; // only BCF is ready for output, VCF will need to unpack again + return 0; +} + +int bcf_is_snp(bcf1_t *v) +{ + int i; + bcf_unpack(v, BCF_UN_STR); + for (i = 0; i < v->n_allele; ++i) + { + if ( v->d.allele[i][1]==0 ) continue; + + // mpileup's <X> allele, see also below. This is not completely satisfactory, + // a general library is here narrowly tailored to fit samtools. + if ( v->d.allele[i][0]=='<' && v->d.allele[i][1]=='X' && v->d.allele[i][2]=='>' ) continue; + + break; + } + return i == v->n_allele; +} + +static void bcf_set_variant_type(const char *ref, const char *alt, variant_t *var) +{ + // The most frequent case + if ( !ref[1] && !alt[1] ) + { + if ( *alt == '.' || *ref==*alt ) { var->n = 0; var->type = VCF_REF; return; } + if ( *alt == 'X' ) { var->n = 0; var->type = VCF_REF; return; } // mpileup's X allele shouldn't be treated as variant + var->n = 1; var->type = VCF_SNP; return; + } + if ( alt[0]=='<' ) + { + if ( alt[1]=='X' && alt[2]=='>' ) { var->n = 0; var->type = VCF_REF; return; } // mpileup's X allele shouldn't be treated as variant + var->type = VCF_OTHER; + return; + } + + const char *r = ref, *a = alt; + while (*r && *a && *r==*a ) { r++; a++; } + + if ( *a && !*r ) + { + while ( *a ) a++; + var->n = (a-alt)-(r-ref); var->type = VCF_INDEL; return; + } + else if ( *r && !*a ) + { + while ( *r ) r++; + var->n = (a-alt)-(r-ref); var->type = VCF_INDEL; return; + } + else if ( !*r && !*a ) + { + var->n = 0; var->type = VCF_REF; return; + } + + const char *re = r, *ae = a; + while ( re[1] ) re++; + while ( ae[1] ) ae++; + while ( *re==*ae && re>r && ae>a ) { re--; ae--; } + if ( ae==a ) + { + if ( re==r ) { var->n = 1; var->type = VCF_SNP; return; } + var->n = -(re-r); + if ( *re==*ae ) { var->type = VCF_INDEL; return; } + var->type = VCF_OTHER; return; + } + else if ( re==r ) + { + var->n = ae-a; + if ( *re==*ae ) { var->type = VCF_INDEL; return; } + var->type = VCF_OTHER; return; + } + + var->type = ( re-r == ae-a ) ? VCF_MNP : VCF_OTHER; + var->n = ( re-r > ae-a ) ? -(re-r+1) : ae-a+1; + + // should do also complex events, SVs, etc... +} + +static void bcf_set_variant_types(bcf1_t *b) +{ + if ( !(b->unpacked & BCF_UN_STR) ) bcf_unpack(b, BCF_UN_STR); + bcf_dec_t *d = &b->d; + if ( d->n_var < b->n_allele ) + { + d->var = (variant_t *) realloc(d->var, sizeof(variant_t)*b->n_allele); + d->n_var = b->n_allele; + } + int i; + b->d.var_type = 0; + for (i=1; i<b->n_allele; i++) + { + bcf_set_variant_type(d->allele[0],d->allele[i], &d->var[i]); + b->d.var_type |= d->var[i].type; + //fprintf(stderr,"[set_variant_type] %d %s %s -> %d %d .. %d\n", b->pos+1,d->allele[0],d->allele[i],d->var[i].type,d->var[i].n, b->d.var_type); + } +} + +int bcf_get_variant_types(bcf1_t *rec) +{ + if ( rec->d.var_type==-1 ) bcf_set_variant_types(rec); + return rec->d.var_type; +} +int bcf_get_variant_type(bcf1_t *rec, int ith_allele) +{ + if ( rec->d.var_type==-1 ) bcf_set_variant_types(rec); + return rec->d.var[ith_allele].type; +} + +int bcf_update_info(const bcf_hdr_t *hdr, bcf1_t *line, const char *key, const void *values, int n, int type) +{ + // Is the field already present? + int i, inf_id = bcf_hdr_id2int(hdr,BCF_DT_ID,key); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_INFO,inf_id) ) return -1; // No such INFO field in the header + if ( !(line->unpacked & BCF_UN_INFO) ) bcf_unpack(line, BCF_UN_INFO); + + for (i=0; i<line->n_info; i++) + if ( inf_id==line->d.info[i].key ) break; + bcf_info_t *inf = i==line->n_info ? NULL : &line->d.info[i]; + + if ( !n || (type==BCF_HT_STR && !values) ) + { + if ( inf ) + { + // Mark the tag for removal, free existing memory if necessary + if ( inf->vptr_free ) + { + free(inf->vptr - inf->vptr_off); + inf->vptr_free = 0; + } + line->d.shared_dirty |= BCF1_DIRTY_INF; + inf->vptr = NULL; + } + return 0; + } + + // Encode the values and determine the size required to accommodate the values + kstring_t str = {0,0,0}; + bcf_enc_int1(&str, inf_id); + if ( type==BCF_HT_INT ) + bcf_enc_vint(&str, n, (int32_t*)values, -1); + else if ( type==BCF_HT_REAL ) + bcf_enc_vfloat(&str, n, (float*)values); + else if ( type==BCF_HT_FLAG || type==BCF_HT_STR ) + { + if ( values==NULL ) + bcf_enc_size(&str, 0, BCF_BT_NULL); + else + bcf_enc_vchar(&str, strlen((char*)values), (char*)values); + } + else + { + fprintf(stderr, "[E::%s] the type %d not implemented yet\n", __func__, type); + abort(); + } + + // Is the INFO tag already present + if ( inf ) + { + // Is it big enough to accommodate new block? + if ( str.l <= inf->vptr_len + inf->vptr_off ) + { + if ( str.l != inf->vptr_len + inf->vptr_off ) line->d.shared_dirty |= BCF1_DIRTY_INF; + uint8_t *ptr = inf->vptr - inf->vptr_off; + memcpy(ptr, str.s, str.l); + free(str.s); + int vptr_free = inf->vptr_free; + bcf_unpack_info_core1(ptr, inf); + inf->vptr_free = vptr_free; + } + else + { + assert( !inf->vptr_free ); // fix the caller or improve here: this has been modified before + bcf_unpack_info_core1((uint8_t*)str.s, inf); + inf->vptr_free = 1; + line->d.shared_dirty |= BCF1_DIRTY_INF; + } + } + else + { + // The tag is not present, create new one + line->n_info++; + hts_expand0(bcf_info_t, line->n_info, line->d.m_info , line->d.info); + inf = &line->d.info[line->n_info-1]; + bcf_unpack_info_core1((uint8_t*)str.s, inf); + inf->vptr_free = 1; + line->d.shared_dirty |= BCF1_DIRTY_INF; + } + line->unpacked |= BCF_UN_INFO; + return 0; +} + +int bcf_update_format_string(const bcf_hdr_t *hdr, bcf1_t *line, const char *key, const char **values, int n) +{ + if ( !n ) + return bcf_update_format(hdr,line,key,NULL,0,BCF_HT_STR); + + int i, max_len = 0; + for (i=0; i<n; i++) + { + int len = strlen(values[i]); + if ( len > max_len ) max_len = len; + } + char *out = (char*) malloc(max_len*n); + if ( !out ) return -2; + for (i=0; i<n; i++) + { + char *dst = out+i*max_len; + const char *src = values[i]; + int j = 0; + while ( src[j] ) { dst[j] = src[j]; j++; } + for (; j<max_len; j++) dst[j] = 0; + } + int ret = bcf_update_format(hdr,line,key,out,max_len*n,BCF_HT_STR); + free(out); + return ret; +} + +int bcf_update_format(const bcf_hdr_t *hdr, bcf1_t *line, const char *key, const void *values, int n, int type) +{ + // Is the field already present? + int i, fmt_id = bcf_hdr_id2int(hdr,BCF_DT_ID,key); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_FMT,fmt_id) ) + { + if ( !n ) return 0; + return -1; // the key not present in the header + } + + if ( !(line->unpacked & BCF_UN_FMT) ) bcf_unpack(line, BCF_UN_FMT); + + for (i=0; i<line->n_fmt; i++) + if ( line->d.fmt[i].id==fmt_id ) break; + bcf_fmt_t *fmt = i==line->n_fmt ? NULL : &line->d.fmt[i]; + + if ( !n ) + { + if ( fmt ) + { + // Mark the tag for removal, free existing memory if necessary + if ( fmt->p_free ) + { + free(fmt->p - fmt->p_off); + fmt->p_free = 0; + } + line->d.indiv_dirty = 1; + fmt->p = NULL; + } + return 0; + } + + line->n_sample = bcf_hdr_nsamples(hdr); + int nps = n / line->n_sample; // number of values per sample + assert( nps && nps*line->n_sample==n ); // must be divisible by n_sample + + // Encode the values and determine the size required to accommodate the values + kstring_t str = {0,0,0}; + bcf_enc_int1(&str, fmt_id); + if ( type==BCF_HT_INT ) + bcf_enc_vint(&str, n, (int32_t*)values, nps); + else if ( type==BCF_HT_REAL ) + { + bcf_enc_size(&str, nps, BCF_BT_FLOAT); + kputsn((char*)values, nps*line->n_sample*sizeof(float), &str); + } + else if ( type==BCF_HT_STR ) + { + bcf_enc_size(&str, nps, BCF_BT_CHAR); + kputsn((char*)values, nps*line->n_sample, &str); + } + else + { + fprintf(stderr, "[E::%s] the type %d not implemented yet\n", __func__, type); + abort(); + } + + if ( !fmt ) + { + // Not present, new format field + line->n_fmt++; + hts_expand0(bcf_fmt_t, line->n_fmt, line->d.m_fmt, line->d.fmt); + + // Special case: VCF specification requires that GT is always first + if ( line->n_fmt > 1 && key[0]=='G' && key[1]=='T' && !key[2] ) + { + for (i=line->n_fmt-1; i>0; i--) + line->d.fmt[i] = line->d.fmt[i-1]; + fmt = &line->d.fmt[0]; + } + else + fmt = &line->d.fmt[line->n_fmt-1]; + bcf_unpack_fmt_core1((uint8_t*)str.s, line->n_sample, fmt); + line->d.indiv_dirty = 1; + fmt->p_free = 1; + } + else + { + // The tag is already present, check if it is big enough to accomodate the new block + if ( str.l <= fmt->p_len + fmt->p_off ) + { + // good, the block is big enough + if ( str.l != fmt->p_len + fmt->p_off ) line->d.indiv_dirty = 1; + uint8_t *ptr = fmt->p - fmt->p_off; + memcpy(ptr, str.s, str.l); + free(str.s); + int p_free = fmt->p_free; + bcf_unpack_fmt_core1(ptr, line->n_sample, fmt); + fmt->p_free = p_free; + } + else + { + assert( !fmt->p_free ); // fix the caller or improve here: this has been modified before + bcf_unpack_fmt_core1((uint8_t*)str.s, line->n_sample, fmt); + fmt->p_free = 1; + line->d.indiv_dirty = 1; + } + } + line->unpacked |= BCF_UN_FMT; + return 0; +} + + +int bcf_update_filter(const bcf_hdr_t *hdr, bcf1_t *line, int *flt_ids, int n) +{ + if ( !(line->unpacked & BCF_UN_FLT) ) bcf_unpack(line, BCF_UN_FLT); + line->d.shared_dirty |= BCF1_DIRTY_FLT; + line->d.n_flt = n; + if ( !n ) return 0; + hts_expand(int, line->d.n_flt, line->d.m_flt, line->d.flt); + int i; + for (i=0; i<n; i++) + line->d.flt[i] = flt_ids[i]; + return 0; +} + +int bcf_add_filter(const bcf_hdr_t *hdr, bcf1_t *line, int flt_id) +{ + if ( !(line->unpacked & BCF_UN_FLT) ) bcf_unpack(line, BCF_UN_FLT); + int i; + for (i=0; i<line->d.n_flt; i++) + if ( flt_id==line->d.flt[i] ) break; + if ( i<line->d.n_flt ) return 0; // this filter is already set + line->d.shared_dirty |= BCF1_DIRTY_FLT; + if ( flt_id==0 ) // set to PASS + line->d.n_flt = 1; + else if ( line->d.n_flt==1 && line->d.flt[0]==0 ) + line->d.n_flt = 1; + else + line->d.n_flt++; + hts_expand(int, line->d.n_flt, line->d.m_flt, line->d.flt); + line->d.flt[line->d.n_flt-1] = flt_id; + return 1; +} +int bcf_remove_filter(const bcf_hdr_t *hdr, bcf1_t *line, int flt_id, int pass) +{ + if ( !(line->unpacked & BCF_UN_FLT) ) bcf_unpack(line, BCF_UN_FLT); + int i; + for (i=0; i<line->d.n_flt; i++) + if ( flt_id==line->d.flt[i] ) break; + if ( i==line->d.n_flt ) return 0; // the filter is not present + line->d.shared_dirty |= BCF1_DIRTY_FLT; + if ( i!=line->d.n_flt-1 ) memmove(line->d.flt+i,line->d.flt+i+1,(line->d.n_flt-i-1)*sizeof(*line->d.flt)); + line->d.n_flt--; + if ( !line->d.n_flt && pass ) bcf_add_filter(hdr,line,0); + return 0; +} + +int bcf_has_filter(const bcf_hdr_t *hdr, bcf1_t *line, char *filter) +{ + if ( filter[0]=='.' && !filter[1] ) filter = "PASS"; + int id = bcf_hdr_id2int(hdr, BCF_DT_ID, filter); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_FLT,id) ) return -1; // not defined in the header + + if ( !(line->unpacked & BCF_UN_FLT) ) bcf_unpack(line, BCF_UN_FLT); + if ( id==0 && !line->d.n_flt) return 1; // PASS + + int i; + for (i=0; i<line->d.n_flt; i++) + if ( line->d.flt[i]==id ) return 1; + return 0; +} + +static inline int _bcf1_sync_alleles(const bcf_hdr_t *hdr, bcf1_t *line, int nals) +{ + line->d.shared_dirty |= BCF1_DIRTY_ALS; + + line->n_allele = nals; + hts_expand(char*, line->n_allele, line->d.m_allele, line->d.allele); + + char *als = line->d.als; + int n = 0; + while (n<nals) + { + line->d.allele[n] = als; + while ( *als ) als++; + als++; + n++; + } + return 0; +} +int bcf_update_alleles(const bcf_hdr_t *hdr, bcf1_t *line, const char **alleles, int nals) +{ + kstring_t tmp = {0,0,0}; + char *free_old = NULL; + + // If the supplied alleles are not pointers to line->d.als, the existing block can be reused. + int i; + for (i=0; i<nals; i++) + if ( alleles[i]>=line->d.als && alleles[i]<line->d.als+line->d.m_als ) break; + if ( i==nals ) + { + // all alleles point elsewhere, reuse the existing block + tmp.l = 0; tmp.s = line->d.als; tmp.m = line->d.m_als; + } + else + free_old = line->d.als; + + for (i=0; i<nals; i++) + { + kputs(alleles[i], &tmp); + kputc(0, &tmp); + } + line->d.als = tmp.s; line->d.m_als = tmp.m; + free(free_old); + return _bcf1_sync_alleles(hdr,line,nals); +} + +int bcf_update_alleles_str(const bcf_hdr_t *hdr, bcf1_t *line, const char *alleles_string) +{ + kstring_t tmp; + tmp.l = 0; tmp.s = line->d.als; tmp.m = line->d.m_als; + kputs(alleles_string, &tmp); + line->d.als = tmp.s; line->d.m_als = tmp.m; + + int nals = 1; + char *t = line->d.als; + while (*t) + { + if ( *t==',' ) { *t = 0; nals++; } + t++; + } + return _bcf1_sync_alleles(hdr, line, nals); +} + +int bcf_update_id(const bcf_hdr_t *hdr, bcf1_t *line, const char *id) +{ + kstring_t tmp; + tmp.l = 0; tmp.s = line->d.id; tmp.m = line->d.m_id; + if ( id ) + kputs(id, &tmp); + else + kputs(".", &tmp); + line->d.id = tmp.s; line->d.m_id = tmp.m; + line->d.shared_dirty |= BCF1_DIRTY_ID; + return 0; +} + +bcf_fmt_t *bcf_get_fmt(const bcf_hdr_t *hdr, bcf1_t *line, const char *key) +{ + int id = bcf_hdr_id2int(hdr, BCF_DT_ID, key); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_FMT,id) ) return NULL; // no such FMT field in the header + return bcf_get_fmt_id(line, id); +} + +bcf_info_t *bcf_get_info(const bcf_hdr_t *hdr, bcf1_t *line, const char *key) +{ + int id = bcf_hdr_id2int(hdr, BCF_DT_ID, key); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_INFO,id) ) return NULL; // no such INFO field in the header + return bcf_get_info_id(line, id); +} + +bcf_fmt_t *bcf_get_fmt_id(bcf1_t *line, const int id) +{ + int i; + if ( !(line->unpacked & BCF_UN_FMT) ) bcf_unpack(line, BCF_UN_FMT); + for (i=0; i<line->n_fmt; i++) + { + if ( line->d.fmt[i].id==id ) return &line->d.fmt[i]; + } + return NULL; +} + +bcf_info_t *bcf_get_info_id(bcf1_t *line, const int id) +{ + int i; + if ( !(line->unpacked & BCF_UN_INFO) ) bcf_unpack(line, BCF_UN_INFO); + for (i=0; i<line->n_info; i++) + { + if ( line->d.info[i].key==id ) return &line->d.info[i]; + } + return NULL; +} + + +int bcf_get_info_values(const bcf_hdr_t *hdr, bcf1_t *line, const char *tag, void **dst, int *ndst, int type) +{ + int i,j, tag_id = bcf_hdr_id2int(hdr, BCF_DT_ID, tag); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_INFO,tag_id) ) return -1; // no such INFO field in the header + if ( bcf_hdr_id2type(hdr,BCF_HL_INFO,tag_id)!=type ) return -2; // expected different type + + if ( !(line->unpacked & BCF_UN_INFO) ) bcf_unpack(line, BCF_UN_INFO); + + for (i=0; i<line->n_info; i++) + if ( line->d.info[i].key==tag_id ) break; + if ( i==line->n_info ) return ( type==BCF_HT_FLAG ) ? 0 : -3; // the tag is not present in this record + if ( type==BCF_HT_FLAG ) return 1; + + bcf_info_t *info = &line->d.info[i]; + if ( type==BCF_HT_STR ) + { + if ( *ndst < info->len+1 ) + { + *ndst = info->len + 1; + *dst = realloc(*dst, *ndst); + } + memcpy(*dst,info->vptr,info->len); + ((uint8_t*)*dst)[info->len] = 0; + return info->len; + } + + // Make sure the buffer is big enough + int size1 = type==BCF_HT_INT ? sizeof(int32_t) : sizeof(float); + if ( *ndst < info->len ) + { + *ndst = info->len; + *dst = realloc(*dst, *ndst * size1); + } + + if ( info->len == 1 ) + { + if ( info->type==BCF_BT_FLOAT ) *((float*)*dst) = info->v1.f; + else + { + #define BRANCH(type_t, missing) { \ + if ( info->v1.i==missing ) *((int32_t*)*dst) = bcf_int32_missing; \ + else *((int32_t*)*dst) = info->v1.i; \ + } + switch (info->type) + { + case BCF_BT_INT8: BRANCH(int8_t, bcf_int8_missing ); break; + case BCF_BT_INT16: BRANCH(int16_t, bcf_int16_missing); break; + case BCF_BT_INT32: BRANCH(int32_t, bcf_int32_missing); break; + } + #undef BRANCH + } + return 1; + } + + #define BRANCH(type_t, is_missing, is_vector_end, set_missing, out_type_t) { \ + out_type_t *tmp = (out_type_t *) *dst; \ + type_t *p = (type_t *) info->vptr; \ + for (j=0; j<info->len; j++) \ + { \ + if ( is_vector_end ) return j; \ + if ( is_missing ) set_missing; \ + else *tmp = p[j]; \ + tmp++; \ + } \ + return j; \ + } + switch (info->type) { + case BCF_BT_INT8: BRANCH(int8_t, p[j]==bcf_int8_missing, p[j]==bcf_int8_vector_end, *tmp=bcf_int32_missing, int32_t); break; + case BCF_BT_INT16: BRANCH(int16_t, p[j]==bcf_int16_missing, p[j]==bcf_int16_vector_end, *tmp=bcf_int32_missing, int32_t); break; + case BCF_BT_INT32: BRANCH(int32_t, p[j]==bcf_int32_missing, p[j]==bcf_int32_vector_end, *tmp=bcf_int32_missing, int32_t); break; + case BCF_BT_FLOAT: BRANCH(float, bcf_float_is_missing(p[j]), bcf_float_is_vector_end(p[j]), bcf_float_set_missing(*tmp), float); break; + default: fprintf(stderr,"TODO: %s:%d .. info->type=%d\n", __FILE__,__LINE__, info->type); exit(1); + } + #undef BRANCH + return -4; // this can never happen +} + +int bcf_get_format_string(const bcf_hdr_t *hdr, bcf1_t *line, const char *tag, char ***dst, int *ndst) +{ + int i,tag_id = bcf_hdr_id2int(hdr, BCF_DT_ID, tag); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_FMT,tag_id) ) return -1; // no such FORMAT field in the header + if ( bcf_hdr_id2type(hdr,BCF_HL_FMT,tag_id)!=BCF_HT_STR ) return -2; // expected different type + + if ( !(line->unpacked & BCF_UN_FMT) ) bcf_unpack(line, BCF_UN_FMT); + + for (i=0; i<line->n_fmt; i++) + if ( line->d.fmt[i].id==tag_id ) break; + if ( i==line->n_fmt ) return -3; // the tag is not present in this record + bcf_fmt_t *fmt = &line->d.fmt[i]; + + int nsmpl = bcf_hdr_nsamples(hdr); + if ( !*dst ) + { + *dst = (char**) malloc(sizeof(char*)*nsmpl); + if ( !*dst ) return -4; // could not alloc + (*dst)[0] = NULL; + } + int n = (fmt->n+1)*nsmpl; + if ( *ndst < n ) + { + (*dst)[0] = realloc((*dst)[0], n); + if ( !(*dst)[0] ) return -4; // could not alloc + *ndst = n; + } + for (i=0; i<nsmpl; i++) + { + uint8_t *src = fmt->p + i*fmt->n; + uint8_t *tmp = (uint8_t*)(*dst)[0] + i*(fmt->n+1); + memcpy(tmp,src,fmt->n); + tmp[fmt->n] = 0; + (*dst)[i] = (char*) tmp; + } + return n; +} + +int bcf_get_format_values(const bcf_hdr_t *hdr, bcf1_t *line, const char *tag, void **dst, int *ndst, int type) +{ + int i,j, tag_id = bcf_hdr_id2int(hdr, BCF_DT_ID, tag); + if ( !bcf_hdr_idinfo_exists(hdr,BCF_HL_FMT,tag_id) ) return -1; // no such FORMAT field in the header + if ( tag[0]=='G' && tag[1]=='T' && tag[2]==0 ) + { + // Ugly: GT field is considered to be a string by the VCF header but BCF represents it as INT. + if ( bcf_hdr_id2type(hdr,BCF_HL_FMT,tag_id)!=BCF_HT_STR ) return -2; + } + else if ( bcf_hdr_id2type(hdr,BCF_HL_FMT,tag_id)!=type ) return -2; // expected different type + + if ( !(line->unpacked & BCF_UN_FMT) ) bcf_unpack(line, BCF_UN_FMT); + + for (i=0; i<line->n_fmt; i++) + if ( line->d.fmt[i].id==tag_id ) break; + if ( i==line->n_fmt ) return -3; // the tag is not present in this record + bcf_fmt_t *fmt = &line->d.fmt[i]; + + if ( type==BCF_HT_STR ) + { + int n = fmt->n*bcf_hdr_nsamples(hdr); + if ( *ndst < n ) + { + *dst = realloc(*dst, n); + if ( !*dst ) return -4; // could not alloc + *ndst = n; + } + memcpy(*dst,fmt->p,n); + return n; + } + + // Make sure the buffer is big enough + int nsmpl = bcf_hdr_nsamples(hdr); + int size1 = type==BCF_HT_INT ? sizeof(int32_t) : sizeof(float); + if ( *ndst < fmt->n*nsmpl ) + { + *ndst = fmt->n*nsmpl; + *dst = realloc(*dst, *ndst*size1); + if ( !dst ) return -4; // could not alloc + } + + #define BRANCH(type_t, is_missing, is_vector_end, set_missing, set_vector_end, out_type_t) { \ + out_type_t *tmp = (out_type_t *) *dst; \ + type_t *p = (type_t*) fmt->p; \ + for (i=0; i<nsmpl; i++) \ + { \ + for (j=0; j<fmt->n; j++) \ + { \ + if ( is_missing ) set_missing; \ + else if ( is_vector_end ) { set_vector_end; break; } \ + else *tmp = p[j]; \ + tmp++; \ + } \ + for (; j<fmt->n; j++) { set_vector_end; tmp++; } \ + p = (type_t *)((char *)p + fmt->size); \ + } \ + } + switch (fmt->type) { + case BCF_BT_INT8: BRANCH(int8_t, p[j]==bcf_int8_missing, p[j]==bcf_int8_vector_end, *tmp=bcf_int32_missing, *tmp=bcf_int32_vector_end, int32_t); break; + case BCF_BT_INT16: BRANCH(int16_t, p[j]==bcf_int16_missing, p[j]==bcf_int16_vector_end, *tmp=bcf_int32_missing, *tmp=bcf_int32_vector_end, int32_t); break; + case BCF_BT_INT32: BRANCH(int32_t, p[j]==bcf_int32_missing, p[j]==bcf_int32_vector_end, *tmp=bcf_int32_missing, *tmp=bcf_int32_vector_end, int32_t); break; + case BCF_BT_FLOAT: BRANCH(float, bcf_float_is_missing(p[j]), bcf_float_is_vector_end(p[j]), bcf_float_set_missing(*tmp), bcf_float_set_vector_end(*tmp), float); break; + default: fprintf(stderr,"TODO: %s:%d .. fmt->type=%d\n", __FILE__,__LINE__, fmt->type); exit(1); + } + #undef BRANCH + return nsmpl*fmt->n; +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/vcf_sweep.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,182 @@ +/* vcf_sweep.c -- forward/reverse sweep API. + + Copyright (C) 2013 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include "htslib/vcf_sweep.h" +#include "htslib/bgzf.h" + +#define SW_FWD 0 +#define SW_BWD 1 + +struct _bcf_sweep_t +{ + htsFile *file; + bcf_hdr_t *hdr; + BGZF *fp; + + int direction; // to tell if the direction has changed + int block_size; // the size of uncompressed data to hold in memory + bcf1_t *rec; // bcf buffer + int nrec, mrec; // number of used records; total size of the buffer + int lrid, lpos, lnals, lals_len, mlals; // to check uniqueness of a record + char *lals; + + uint64_t *idx; // uncompressed offsets of VCF/BCF records + int iidx, nidx, midx; // i: current offset; n: used; m: allocated + int idx_done; // the index is built during the first pass +}; + +BGZF *hts_get_bgzfp(htsFile *fp); +int hts_useek(htsFile *file, long uoffset, int where); +long hts_utell(htsFile *file); + +static inline int sw_rec_equal(bcf_sweep_t *sw, bcf1_t *rec) +{ + if ( sw->lrid!=rec->rid ) return 0; + if ( sw->lpos!=rec->pos ) return 0; + if ( sw->lnals!=rec->n_allele ) return 0; + + char *t = rec->d.allele[sw->lnals-1]; + int len = t - rec->d.allele[0] + 1; + while ( *t ) { t++; len++; } + if ( sw->lals_len!=len ) return 0; + if ( memcmp(sw->lals,rec->d.allele[0],len) ) return 0; + return 1; +} + +static void sw_rec_save(bcf_sweep_t *sw, bcf1_t *rec) +{ + sw->lrid = rec->rid; + sw->lpos = rec->pos; + sw->lnals = rec->n_allele; + + char *t = rec->d.allele[sw->lnals-1]; + int len = t - rec->d.allele[0] + 1; + while ( *t ) { t++; len++; } + sw->lals_len = len; + hts_expand(char, len, sw->mlals, sw->lals); + memcpy(sw->lals, rec->d.allele[0], len); +} + +static void sw_fill_buffer(bcf_sweep_t *sw) +{ + if ( !sw->iidx ) return; + sw->iidx--; + + int ret = hts_useek(sw->file, sw->idx[sw->iidx], 0); + assert( ret==0 ); + + sw->nrec = 0; + bcf1_t *rec = &sw->rec[sw->nrec]; + while ( (ret=bcf_read1(sw->file, sw->hdr, rec))==0 ) + { + bcf_unpack(rec, BCF_UN_STR); + + // if not in the last block, stop at the saved record + if ( sw->iidx+1 < sw->nidx && sw_rec_equal(sw,rec) ) break; + + sw->nrec++; + hts_expand0(bcf1_t, sw->nrec+1, sw->mrec, sw->rec); + rec = &sw->rec[sw->nrec]; + } + sw_rec_save(sw, &sw->rec[0]); +} + +bcf_sweep_t *bcf_sweep_init(const char *fname) +{ + bcf_sweep_t *sw = (bcf_sweep_t*) calloc(1,sizeof(bcf_sweep_t)); + sw->file = hts_open(fname, "r"); + sw->fp = hts_get_bgzfp(sw->file); + bgzf_index_build_init(sw->fp); + sw->hdr = bcf_hdr_read(sw->file); + sw->mrec = 1; + sw->rec = (bcf1_t*) calloc(sw->mrec,(sizeof(bcf1_t))); + sw->block_size = 1024*1024*3; + sw->direction = SW_FWD; + return sw; +} + +void bcf_empty1(bcf1_t *v); +void bcf_sweep_destroy(bcf_sweep_t *sw) +{ + int i; + for (i=0; i<sw->mrec; i++) bcf_empty1(&sw->rec[i]); + free(sw->idx); + free(sw->rec); + free(sw->lals); + bcf_hdr_destroy(sw->hdr); + hts_close(sw->file); + free(sw); +} + +static void sw_seek(bcf_sweep_t *sw, int direction) +{ + sw->direction = direction; + if ( direction==SW_FWD ) + hts_useek(sw->file, sw->idx[0], 0); + else + { + sw->iidx = sw->nidx; + sw->nrec = 0; + } +} + +bcf1_t *bcf_sweep_fwd(bcf_sweep_t *sw) +{ + if ( sw->direction==SW_BWD ) sw_seek(sw, SW_FWD); + + long pos = hts_utell(sw->file); + + bcf1_t *rec = &sw->rec[0]; + int ret = bcf_read1(sw->file, sw->hdr, rec); + + if ( ret!=0 ) // last record, get ready for sweeping backwards + { + sw->idx_done = 1; + sw->fp->idx_build_otf = 0; + sw_seek(sw, SW_BWD); + return NULL; + } + + if ( !sw->idx_done ) + { + if ( !sw->nidx || pos - sw->idx[sw->nidx-1] > sw->block_size ) + { + sw->nidx++; + hts_expand(uint64_t, sw->nidx, sw->midx, sw->idx); + sw->idx[sw->nidx-1] = pos; + } + } + return rec; +} + +bcf1_t *bcf_sweep_bwd(bcf_sweep_t *sw) +{ + if ( sw->direction==SW_FWD ) sw_seek(sw, SW_BWD); + if ( !sw->nrec ) sw_fill_buffer(sw); + if ( !sw->nrec ) return NULL; + return &sw->rec[ --sw->nrec ]; +} + +bcf_hdr_t *bcf_sweep_hdr(bcf_sweep_t *sw) { return sw->hdr; } +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/vcfutils.c Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,675 @@ +/* vcfutils.c -- allele-related utility functions. + + Copyright (C) 2012-2014 Genome Research Ltd. + + Author: Petr Danecek <pd3@sanger.ac.uk> + +Permission is hereby granted, free of charge, to any person obtaining a copy +of this software and associated documentation files (the "Software"), to deal +in the Software without restriction, including without limitation the rights +to use, copy, modify, merge, publish, distribute, sublicense, and/or sell +copies of the Software, and to permit persons to whom the Software is +furnished to do so, subject to the following conditions: + +The above copyright notice and this permission notice shall be included in +all copies or substantial portions of the Software. + +THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR +IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, +FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL +THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER +LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING +FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER +DEALINGS IN THE SOFTWARE. */ + +#include "htslib/vcfutils.h" + +int bcf_calc_ac(const bcf_hdr_t *header, bcf1_t *line, int *ac, int which) +{ + int i; + for (i=0; i<line->n_allele; i++) ac[i]=0; + + // Use INFO/AC,AN field only when asked + if ( which&BCF_UN_INFO ) + { + bcf_unpack(line, BCF_UN_INFO); + int an_id = bcf_hdr_id2int(header, BCF_DT_ID, "AN"); + int ac_id = bcf_hdr_id2int(header, BCF_DT_ID, "AC"); + int i, an=-1, ac_len=0, ac_type=0; + uint8_t *ac_ptr=NULL; + if ( an_id>=0 && ac_id>=0 ) + { + for (i=0; i<line->n_info; i++) + { + bcf_info_t *z = &line->d.info[i]; + if ( z->key == an_id ) an = z->v1.i; + else if ( z->key == ac_id ) { ac_ptr = z->vptr; ac_len = z->len; ac_type = z->type; } + } + } + if ( an>=0 && ac_ptr ) + { + int nac = 0; + #define BRANCH_INT(type_t) { \ + type_t *p = (type_t *) ac_ptr; \ + for (i=0; i<ac_len; i++) \ + { \ + ac[i+1] = p[i]; \ + nac += p[i]; \ + } \ + } + switch (ac_type) { + case BCF_BT_INT8: BRANCH_INT(int8_t); break; + case BCF_BT_INT16: BRANCH_INT(int16_t); break; + case BCF_BT_INT32: BRANCH_INT(int32_t); break; + default: fprintf(stderr, "[E::%s] todo: %d at %s:%d\n", __func__, ac_type, header->id[BCF_DT_CTG][line->rid].key, line->pos+1); exit(1); break; + } + #undef BRANCH_INT + if ( an<nac ) + { + fprintf(stderr,"[E::%s] Incorrect AN/AC counts at %s:%d\n", __func__,header->id[BCF_DT_CTG][line->rid].key, line->pos+1); + exit(1); + } + ac[0] = an - nac; + return 1; + } + } + + // Split genotype fields only when asked + if ( which&BCF_UN_FMT ) + { + int i, gt_id = bcf_hdr_id2int(header,BCF_DT_ID,"GT"); + if ( gt_id<0 ) return 0; + bcf_unpack(line, BCF_UN_FMT); + bcf_fmt_t *fmt_gt = NULL; + for (i=0; i<(int)line->n_fmt; i++) + if ( line->d.fmt[i].id==gt_id ) { fmt_gt = &line->d.fmt[i]; break; } + if ( !fmt_gt ) return 0; + #define BRANCH_INT(type_t,vector_end) { \ + for (i=0; i<line->n_sample; i++) \ + { \ + type_t *p = (type_t*) (fmt_gt->p + i*fmt_gt->size); \ + int ial; \ + for (ial=0; ial<fmt_gt->n; ial++) \ + { \ + if ( p[ial]==vector_end ) break; /* smaller ploidy */ \ + if ( bcf_gt_is_missing(p[ial]) ) continue; /* missing allele */ \ + if ( p[ial]>>1 > line->n_allele ) \ + { \ + fprintf(stderr,"[E::%s] Incorrect allele (\"%d\") in %s at %s:%d\n", __func__,(p[ial]>>1)-1, header->samples[i],header->id[BCF_DT_CTG][line->rid].key, line->pos+1); \ + exit(1); \ + } \ + ac[(p[ial]>>1)-1]++; \ + } \ + } \ + } + switch (fmt_gt->type) { + case BCF_BT_INT8: BRANCH_INT(int8_t, bcf_int8_vector_end); break; + case BCF_BT_INT16: BRANCH_INT(int16_t, bcf_int16_vector_end); break; + case BCF_BT_INT32: BRANCH_INT(int32_t, bcf_int32_vector_end); break; + default: fprintf(stderr, "[E::%s] todo: %d at %s:%d\n", __func__, fmt_gt->type, header->id[BCF_DT_CTG][line->rid].key, line->pos+1); exit(1); break; + } + #undef BRANCH_INT + return 1; + } + return 0; +} + +int bcf_gt_type(bcf_fmt_t *fmt_ptr, int isample, int *_ial, int *_jal) +{ + int i, nals = 0, has_ref = 0, has_alt = 0, ial = 0, jal = 0; + #define BRANCH_INT(type_t,vector_end) { \ + type_t *p = (type_t*) (fmt_ptr->p + isample*fmt_ptr->size); \ + for (i=0; i<fmt_ptr->n; i++) \ + { \ + if ( p[i] == vector_end ) break; /* smaller ploidy */ \ + if ( bcf_gt_is_missing(p[i]) ) continue; /* missing allele */ \ + int tmp = p[i]>>1; \ + if ( tmp>1 ) \ + { \ + if ( !ial ) { ial = tmp; has_alt = 1; } \ + else if ( tmp!=ial ) \ + { \ + if ( tmp<ial ) \ + { \ + jal = ial; \ + ial = tmp; \ + } \ + else \ + { \ + jal = tmp; \ + } \ + has_alt = 2; \ + } \ + } \ + else has_ref = 1; \ + nals++; \ + } \ + } + switch (fmt_ptr->type) { + case BCF_BT_INT8: BRANCH_INT(int8_t, bcf_int8_vector_end); break; + case BCF_BT_INT16: BRANCH_INT(int16_t, bcf_int16_vector_end); break; + case BCF_BT_INT32: BRANCH_INT(int32_t, bcf_int32_vector_end); break; + default: fprintf(stderr, "[E::%s] todo: fmt_type %d\n", __func__, fmt_ptr->type); exit(1); break; + } + #undef BRANCH_INT + + if ( _ial ) *_ial = ial>0 ? ial-1 : ial; + if ( _jal ) *_jal = jal>0 ? jal-1 : jal; + if ( !nals ) return GT_UNKN; + if ( nals==1 ) + return has_ref ? GT_HAPL_R : GT_HAPL_A; + if ( !has_ref ) + return has_alt==1 ? GT_HOM_AA : GT_HET_AA; + if ( !has_alt ) + return GT_HOM_RR; + return GT_HET_RA; +} + +int bcf_trim_alleles(const bcf_hdr_t *header, bcf1_t *line) +{ + int i; + bcf_fmt_t *gt = bcf_get_fmt(header, line, "GT"); + if ( !gt ) return 0; + + int *ac = (int*) calloc(line->n_allele,sizeof(int)); + + // check if all alleles are populated + #define BRANCH(type_t,vector_end) { \ + for (i=0; i<line->n_sample; i++) \ + { \ + type_t *p = (type_t*) (gt->p + i*gt->size); \ + int ial; \ + for (ial=0; ial<gt->n; ial++) \ + { \ + if ( p[ial]==vector_end ) break; /* smaller ploidy */ \ + if ( bcf_gt_is_missing(p[ial]) ) continue; /* missing allele */ \ + if ( (p[ial]>>1)-1 >= line->n_allele ) { free(ac); return -1; } \ + ac[(p[ial]>>1)-1]++; \ + } \ + } \ + } + switch (gt->type) { + case BCF_BT_INT8: BRANCH(int8_t, bcf_int8_vector_end); break; + case BCF_BT_INT16: BRANCH(int16_t, bcf_int16_vector_end); break; + case BCF_BT_INT32: BRANCH(int32_t, bcf_int32_vector_end); break; + default: fprintf(stderr, "[E::%s] todo: %d at %s:%d\n", __func__, gt->type, header->id[BCF_DT_CTG][line->rid].key, line->pos+1); exit(1); break; + } + #undef BRANCH + + int rm_als = 0, nrm = 0; + for (i=1; i<line->n_allele; i++) + { + if ( !ac[i] ) { rm_als |= 1<<i; nrm++; } + } + free(ac); + + if ( nrm ) bcf_remove_alleles(header, line, rm_als); + return nrm; +} + +void bcf_remove_alleles(const bcf_hdr_t *header, bcf1_t *line, int rm_mask) +{ + int *map = (int*) calloc(line->n_allele, sizeof(int)); + + // create map of indexes from old to new ALT numbering and modify ALT + kstring_t str = {0,0,0}; + kputs(line->d.allele[0], &str); + + int nrm = 0, i,j; // i: ori alleles, j: new alleles + for (i=1, j=1; i<line->n_allele; i++) + { + if ( rm_mask & 1<<i ) + { + // remove this allele + line->d.allele[i] = NULL; + nrm++; + continue; + } + kputc(',', &str); + kputs(line->d.allele[i], &str); + map[i] = j; + j++; + } + if ( !nrm ) { free(map); free(str.s); return; } + + int nR_ori = line->n_allele; + int nR_new = line->n_allele-nrm; + assert(nR_new > 0); // should not be able to remove reference allele + int nA_ori = nR_ori-1; + int nA_new = nR_new-1; + + int nG_ori = nR_ori*(nR_ori + 1)/2; + int nG_new = nR_new*(nR_new + 1)/2; + + bcf_update_alleles_str(header, line, str.s); + + // remove from Number=G, Number=R and Number=A INFO fields. + uint8_t *dat = NULL; + int mdat = 0, ndat = 0, mdat_bytes = 0, nret; + for (i=0; i<line->n_info; i++) + { + bcf_info_t *info = &line->d.info[i]; + int vlen = bcf_hdr_id2length(header,BCF_HL_INFO,info->key); + + if ( vlen!=BCF_VL_A && vlen!=BCF_VL_G && vlen!=BCF_VL_R ) continue; // no need to change + + int type = bcf_hdr_id2type(header,BCF_HL_INFO,info->key); + if ( type==BCF_HT_FLAG ) continue; + int size = 1; + if ( type==BCF_HT_REAL || type==BCF_HT_INT ) size = 4; + + mdat = mdat_bytes / size; + nret = bcf_get_info_values(header, line, bcf_hdr_int2id(header,BCF_DT_ID,info->key), (void**)&dat, &mdat, type); + mdat_bytes = mdat * size; + if ( nret<0 ) + { + fprintf(stderr,"[%s:%d %s] Could not access INFO/%s at %s:%d [%d]\n", __FILE__,__LINE__,__FUNCTION__, + bcf_hdr_int2id(header,BCF_DT_ID,info->key), bcf_seqname(header,line), line->pos+1, nret); + exit(1); + } + if ( type==BCF_HT_STR ) + { + str.l = 0; + char *ss = (char*) dat, *se = (char*) dat; + if ( vlen==BCF_VL_A || vlen==BCF_VL_R ) + { + int nexp, inc = 0; + if ( vlen==BCF_VL_A ) + { + nexp = nA_ori; + inc = 1; + } + else + nexp = nR_ori; + for (j=0; j<nexp; j++) + { + if ( !*se ) break; + while ( *se && *se!=',' ) se++; + if ( rm_mask & 1<<(j+inc) ) + { + if ( *se ) se++; + ss = se; + continue; + } + if ( str.l ) kputc(',',&str); + kputsn(ss,se-ss,&str); + if ( *se ) se++; + ss = se; + } + assert( j==nexp ); + } + else // Number=G, assuming diploid genotype + { + int k = 0, n = 0; + for (j=0; j<nR_ori; j++) + { + for (k=0; k<=j; k++) + { + if ( !*se ) break; + while ( *se && *se!=',' ) se++; + n++; + if ( rm_mask & 1<<j || rm_mask & 1<<k ) + { + if ( *se ) se++; + ss = se; + continue; + } + if ( str.l ) kputc(',',&str); + kputsn(ss,se-ss,&str); + if ( *se ) se++; + ss = se; + } + if ( !*se ) break; + } + assert( n=nG_ori ); + } + + nret = bcf_update_info(header, line, bcf_hdr_int2id(header,BCF_DT_ID,info->key), (void*)str.s, str.l, type); + if ( nret<0 ) + { + fprintf(stderr,"[%s:%d %s] Could not update INFO/%s at %s:%d [%d]\n", __FILE__,__LINE__,__FUNCTION__, + bcf_hdr_int2id(header,BCF_DT_ID,info->key), bcf_seqname(header,line), line->pos+1, nret); + exit(1); + } + continue; + } + + if ( vlen==BCF_VL_A || vlen==BCF_VL_R ) + { + int inc = 0, ntop; + if ( vlen==BCF_VL_A ) + { + assert( nret==nA_ori ); + ntop = nA_ori; + ndat = nA_new; + inc = 1; + } + else + { + assert( nret==nR_ori ); + ntop = nR_ori; + ndat = nR_new; + } + int k = 0; + + #define BRANCH(type_t,is_vector_end) \ + { \ + type_t *ptr = (type_t*) dat; \ + int size = sizeof(type_t); \ + for (j=0; j<ntop; j++) /* j:ori, k:new */ \ + { \ + if ( is_vector_end ) { memcpy(dat+k*size, dat+j*size, size); break; } \ + if ( rm_mask & 1<<(j+inc) ) continue; \ + if ( j!=k ) memcpy(dat+k*size, dat+j*size, size); \ + k++; \ + } \ + } + switch (type) + { + case BCF_HT_INT: BRANCH(int32_t,ptr[j]==bcf_int32_vector_end); break; + case BCF_HT_REAL: BRANCH(float,bcf_float_is_vector_end(ptr[j])); break; + } + #undef BRANCH + } + else // Number=G + { + assert( nret==nG_ori ); + int k, l_ori = -1, l_new = 0; + ndat = nG_new; + + #define BRANCH(type_t,is_vector_end) \ + { \ + type_t *ptr = (type_t*) dat; \ + int size = sizeof(type_t); \ + for (j=0; j<nR_ori; j++) \ + { \ + for (k=0; k<=j; k++) \ + { \ + l_ori++; \ + if ( is_vector_end ) { memcpy(dat+l_new*size, dat+l_ori*size, size); break; } \ + if ( rm_mask & 1<<j || rm_mask & 1<<k ) continue; \ + if ( l_ori!=l_new ) memcpy(dat+l_new*size, dat+l_ori*size, size); \ + l_new++; \ + } \ + } \ + } + switch (type) + { + case BCF_HT_INT: BRANCH(int32_t,ptr[l_ori]==bcf_int32_vector_end); break; + case BCF_HT_REAL: BRANCH(float,bcf_float_is_vector_end(ptr[l_ori])); break; + } + #undef BRANCH + } + + nret = bcf_update_info(header, line, bcf_hdr_int2id(header,BCF_DT_ID,info->key), (void*)dat, ndat, type); + if ( nret<0 ) + { + fprintf(stderr,"[%s:%d %s] Could not update INFO/%s at %s:%d [%d]\n", __FILE__,__LINE__,__FUNCTION__, + bcf_hdr_int2id(header,BCF_DT_ID,info->key), bcf_seqname(header,line), line->pos+1, nret); + exit(1); + } + } + + // Update GT fields, the allele indexes might have changed + for (i=1; i<line->n_allele; i++) if ( map[i]!=i ) break; + if ( i<line->n_allele ) + { + mdat = mdat_bytes / 4; // sizeof(int32_t) + nret = bcf_get_genotypes(header,line,(void**)&dat,&mdat); + mdat_bytes = mdat * 4; + if ( nret>0 ) + { + nret /= line->n_sample; + int32_t *ptr = (int32_t*) dat; + for (i=0; i<line->n_sample; i++) + { + for (j=0; j<nret; j++) + { + if ( bcf_gt_is_missing(ptr[j]) ) continue; + if ( ptr[j]==bcf_int32_vector_end ) break; + int al = bcf_gt_allele(ptr[j]); + assert( al<nR_ori && map[al]>=0 ); + ptr[j] = (map[al]+1)<<1 | (ptr[j]&1); + } + ptr += nret; + } + bcf_update_genotypes(header, line, (void*)dat, nret*line->n_sample); + } + } + + // Remove from Number=G, Number=R and Number=A FORMAT fields. + // Assuming haploid or diploid GTs + for (i=0; i<line->n_fmt; i++) + { + bcf_fmt_t *fmt = &line->d.fmt[i]; + int vlen = bcf_hdr_id2length(header,BCF_HL_FMT,fmt->id); + + if ( vlen!=BCF_VL_A && vlen!=BCF_VL_G && vlen!=BCF_VL_R ) continue; // no need to change + + int type = bcf_hdr_id2type(header,BCF_HL_FMT,fmt->id); + if ( type==BCF_HT_FLAG ) continue; + + int size = 1; + if ( type==BCF_HT_REAL || type==BCF_HT_INT ) size = 4; + + mdat = mdat_bytes / size; + nret = bcf_get_format_values(header, line, bcf_hdr_int2id(header,BCF_DT_ID,fmt->id), (void**)&dat, &mdat, type); + mdat_bytes = mdat * size; + if ( nret<0 ) + { + fprintf(stderr,"[%s:%d %s] Could not access FORMAT/%s at %s:%d [%d]\n", __FILE__,__LINE__,__FUNCTION__, + bcf_hdr_int2id(header,BCF_DT_ID,fmt->id), bcf_seqname(header,line), line->pos+1, nret); + exit(1); + } + + if ( type==BCF_HT_STR ) + { + int size = nret/line->n_sample; // number of bytes per sample + str.l = 0; + if ( vlen==BCF_VL_A || vlen==BCF_VL_R ) + { + int nexp, inc = 0; + if ( vlen==BCF_VL_A ) + { + nexp = nA_ori; + inc = 1; + } + else + nexp = nR_ori; + for (j=0; j<line->n_sample; j++) + { + char *ss = ((char*)dat) + j*size, *se = ss + size, *ptr = ss; + int k_src = 0, k_dst = 0, l = str.l; + for (k_src=0; k_src<nexp; k_src++) + { + if ( ptr>=se || !*ptr) break; + while ( ptr<se && *ptr && *ptr!=',' ) ptr++; + if ( rm_mask & 1<<(k_src+inc) ) + { + ss = ++ptr; + continue; + } + if ( k_dst ) kputc(',',&str); + kputsn(ss,ptr-ss,&str); + ss = ++ptr; + k_dst++; + } + assert( k_src==nexp ); + l = str.l - l; + for (; l<size; l++) kputc(0, &str); + } + } + else // Number=G, diploid or haploid + { + for (j=0; j<line->n_sample; j++) + { + char *ss = ((char*)dat) + j*size, *se = ss + size, *ptr = ss; + int k_src = 0, k_dst = 0, l = str.l; + int nexp = 0; // diploid or haploid? + while ( ptr<se ) + { + if ( !*ptr ) break; + if ( *ptr==',' ) nexp++; + ptr++; + } + if ( ptr!=ss ) nexp++; + assert( nexp==nG_ori || nexp==nR_ori ); + ptr = ss; + if ( nexp==nG_ori ) // diploid + { + int ia, ib; + for (ia=0; ia<nR_ori; ia++) + { + for (ib=0; ib<=ia; ib++) + { + if ( ptr>=se || !*ptr ) break; + while ( ptr<se && *ptr && *ptr!=',' ) ptr++; + if ( rm_mask & 1<<ia || rm_mask & 1<<ib ) + { + ss = ++ptr; + continue; + } + if ( k_dst ) kputc(',',&str); + kputsn(ss,ptr-ss,&str); + ss = ++ptr; + k_dst++; + } + if ( ptr>=se || !*ptr ) break; + } + } + else // haploid + { + for (k_src=0; k_src<nR_ori; k_src++) + { + if ( ptr>=se || !*ptr ) break; + while ( ptr<se && *ptr && *ptr!=',' ) ptr++; + if ( rm_mask & 1<<k_src ) + { + ss = ++ptr; + continue; + } + if ( k_dst ) kputc(',',&str); + kputsn(ss,ptr-ss,&str); + ss = ++ptr; + k_dst++; + } + assert( k_src==nR_ori ); + l = str.l - l; + for (; l<size; l++) kputc(0, &str); + } + } + } + nret = bcf_update_format(header, line, bcf_hdr_int2id(header,BCF_DT_ID,fmt->id), (void*)str.s, str.l, type); + if ( nret<0 ) + { + fprintf(stderr,"[%s:%d %s] Could not update FORMAT/%s at %s:%d [%d]\n", __FILE__,__LINE__,__FUNCTION__, + bcf_hdr_int2id(header,BCF_DT_ID,fmt->id), bcf_seqname(header,line), line->pos+1, nret); + exit(1); + } + continue; + } + + int nori = nret / line->n_sample; + if ( vlen==BCF_VL_A || vlen==BCF_VL_R || (vlen==BCF_VL_G && nori==nR_ori) ) // Number=A, R or haploid Number=G + { + int inc = 0, nnew; + if ( vlen==BCF_VL_A ) + { + assert( nori==nA_ori ); // todo: will fail if all values are missing + ndat = nA_new*line->n_sample; + nnew = nA_new; + inc = 1; + } + else + { + assert( nori==nR_ori ); // todo: will fail if all values are missing + ndat = nR_new*line->n_sample; + nnew = nR_new; + } + + #define BRANCH(type_t,is_vector_end) \ + { \ + for (j=0; j<line->n_sample; j++) \ + { \ + type_t *ptr_src = ((type_t*)dat) + j*nori; \ + type_t *ptr_dst = ((type_t*)dat) + j*nnew; \ + int size = sizeof(type_t); \ + int k_src, k_dst = 0; \ + for (k_src=0; k_src<nori; k_src++) \ + { \ + if ( is_vector_end ) { memcpy(ptr_dst+k_dst, ptr_src+k_src, size); break; } \ + if ( rm_mask & 1<<(k_src+inc) ) continue; \ + memcpy(ptr_dst+k_dst, ptr_src+k_src, size); \ + k_dst++; \ + } \ + } \ + } + switch (type) + { + case BCF_HT_INT: BRANCH(int32_t,ptr_src[k_src]==bcf_int32_vector_end); break; + case BCF_HT_REAL: BRANCH(float,bcf_float_is_vector_end(ptr_src[k_src])); break; + } + #undef BRANCH + } + else // Number=G, diploid or mixture of haploid+diploid + { + assert( nori==nG_ori ); + ndat = nG_new*line->n_sample; + + #define BRANCH(type_t,is_vector_end) \ + { \ + for (j=0; j<line->n_sample; j++) \ + { \ + type_t *ptr_src = ((type_t*)dat) + j*nori; \ + type_t *ptr_dst = ((type_t*)dat) + j*nG_new; \ + int size = sizeof(type_t); \ + int ia, ib, k_dst = 0, k_src; \ + int nset = 0; /* haploid or diploid? */ \ + for (k_src=0; k_src<nG_ori; k_src++) { if ( is_vector_end ) break; nset++; } \ + if ( nset==nR_ori ) /* haploid */ \ + { \ + for (k_src=0; k_src<nR_ori; k_src++) \ + { \ + if ( rm_mask & 1<<k_src ) continue; \ + memcpy(ptr_dst+k_dst, ptr_src+k_src, size); \ + k_dst++; \ + } \ + memcpy(ptr_dst+k_dst, ptr_src+k_src, size); \ + } \ + else /* diploid */ \ + { \ + k_src = -1; \ + for (ia=0; ia<nR_ori; ia++) \ + { \ + for (ib=0; ib<=ia; ib++) \ + { \ + k_src++; \ + if ( is_vector_end ) { memcpy(ptr_dst+k_dst, ptr_src+k_src, size); ia = nR_ori; break; } \ + if ( rm_mask & 1<<ia || rm_mask & 1<<ib ) continue; \ + memcpy(ptr_dst+k_dst, ptr_src+k_src, size); \ + k_dst++; \ + } \ + } \ + } \ + } \ + } + switch (type) + { + case BCF_HT_INT: BRANCH(int32_t,ptr_src[k_src]==bcf_int32_vector_end); break; + case BCF_HT_REAL: BRANCH(float,bcf_float_is_vector_end(ptr_src[k_src])); break; + } + #undef BRANCH + } + nret = bcf_update_format(header, line, bcf_hdr_int2id(header,BCF_DT_ID,fmt->id), (void*)dat, ndat, type); + if ( nret<0 ) + { + fprintf(stderr,"[%s:%d %s] Could not update FORMAT/%s at %s:%d [%d]\n", __FILE__,__LINE__,__FUNCTION__, + bcf_hdr_int2id(header,BCF_DT_ID,fmt->id), bcf_seqname(header,line), line->pos+1, nret); + exit(1); + } + } + free(dat); + free(str.s); + free(map); +} +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/src/htslib/version.h Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1 @@ +#define HTS_VERSION "1.2.1"
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/exp_data/hg19_rRNA.bed Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,1769 @@ +chr1 1815107 1815204 LSU-rRNA_Hsa 495 + 1815107 1815204 0 1 97 0 +chr1 4417098 4417211 LSU-rRNA_Hsa 234 - 4417098 4417211 0 1 113 0 +chr1 7876433 7876473 5S 282 + 7876433 7876473 0 1 40 0 +chr1 9497766 9497837 5S 467 - 9497766 9497837 0 1 71 0 +chr1 13923133 13923172 5S 256 - 13923133 13923172 0 1 39 0 +chr1 13949705 13949779 5S 432 - 13949705 13949779 0 1 74 0 +chr1 15976864 15976906 5S 266 - 15976864 15976906 0 1 42 0 +chr1 25483508 25483621 LSU-rRNA_Hsa 896 - 25483508 25483621 0 1 113 0 +chr1 28242609 28242680 LSU-rRNA_Hsa 410 - 28242609 28242680 0 1 71 0 +chr1 30802098 30802177 LSU-rRNA_Hsa 270 - 30802098 30802177 0 1 79 0 +chr1 31583541 31583592 5S 354 + 31583541 31583592 0 1 51 0 +chr1 31851406 31851445 5S 270 - 31851406 31851445 0 1 39 0 +chr1 32833269 32833349 SSU-rRNA_Hsa 257 + 32833269 32833349 0 1 80 0 +chr1 34578550 34578639 5S 715 + 34578550 34578639 0 1 89 0 +chr1 37168239 37168281 5S 241 - 37168239 37168281 0 1 42 0 +chr1 37315505 37315568 LSU-rRNA_Hsa 274 - 37315505 37315568 0 1 63 0 +chr1 37730289 37730387 5S 512 - 37730289 37730387 0 1 98 0 +chr1 39354488 39354536 LSU-rRNA_Hsa 293 - 39354488 39354536 0 1 48 0 +chr1 39619878 39619968 5S 684 - 39619878 39619968 0 1 90 0 +chr1 39673433 39673475 5S 239 + 39673433 39673475 0 1 42 0 +chr1 41932607 41932698 5S 604 - 41932607 41932698 0 1 91 0 +chr1 42779298 42779471 LSU-rRNA_Hsa 1102 + 42779298 42779471 0 1 173 0 +chr1 42956316 42956359 5S 230 + 42956316 42956359 0 1 43 0 +chr1 43045772 43046173 LSU-rRNA_Hsa 661 + 43045772 43046173 0 1 401 0 +chr1 43215463 43215643 LSU-rRNA_Hsa 1020 - 43215463 43215643 0 1 180 0 +chr1 43662087 43662177 5S 695 + 43662087 43662177 0 1 90 0 +chr1 44480550 44480593 5S 309 - 44480550 44480593 0 1 43 0 +chr1 45136058 45136137 5S 430 - 45136058 45136137 0 1 79 0 +chr1 45397994 45398096 5S 601 + 45397994 45398096 0 1 102 0 +chr1 45955546 45955598 5S 237 - 45955546 45955598 0 1 52 0 +chr1 46902468 46902566 LSU-rRNA_Hsa 458 - 46902468 46902566 0 1 98 0 +chr1 51524305 51524347 5S 262 - 51524305 51524347 0 1 42 0 +chr1 52439082 52439177 5S 742 + 52439082 52439177 0 1 95 0 +chr1 59213662 59213771 5S 279 + 59213662 59213771 0 1 109 0 +chr1 63652004 63652098 5S 498 - 63652004 63652098 0 1 94 0 +chr1 64356532 64356571 5S 257 + 64356532 64356571 0 1 39 0 +chr1 65154802 65154841 5S 303 - 65154802 65154841 0 1 39 0 +chr1 67016502 67016545 5S 296 - 67016502 67016545 0 1 43 0 +chr1 68458490 68458634 SSU-rRNA_Hsa 613 - 68458490 68458634 0 1 144 0 +chr1 68461907 68462474 SSU-rRNA_Hsa 1930 - 68461907 68462474 0 1 567 0 +chr1 69262049 69262103 5S 261 - 69262049 69262103 0 1 54 0 +chr1 72642633 72642675 5S 316 - 72642633 72642675 0 1 42 0 +chr1 74215218 74215309 5S 659 - 74215218 74215309 0 1 91 0 +chr1 76240336 76240470 LSU-rRNA_Hsa 568 - 76240336 76240470 0 1 134 0 +chr1 78080553 78080625 5S 451 + 78080553 78080625 0 1 72 0 +chr1 78245582 78245672 5S 646 + 78245582 78245672 0 1 90 0 +chr1 78560489 78560589 5S 659 - 78560489 78560589 0 1 100 0 +chr1 78840873 78840952 5S 542 - 78840873 78840952 0 1 79 0 +chr1 80851092 80851133 5S 277 + 80851092 80851133 0 1 41 0 +chr1 86349360 86349480 5S 674 - 86349360 86349480 0 1 120 0 +chr1 87918966 87919056 5S 627 - 87918966 87919056 0 1 90 0 +chr1 89025825 89025866 5S 256 - 89025825 89025866 0 1 41 0 +chr1 91852785 91853147 LSU-rRNA_Hsa 3277 - 91852785 91853147 0 1 362 0 +chr1 92655309 92655379 5S 362 + 92655309 92655379 0 1 70 0 +chr1 92972727 92972802 LSU-rRNA_Hsa 586 - 92972727 92972802 0 1 75 0 +chr1 93953887 93954009 5S 750 - 93953887 93954009 0 1 122 0 +chr1 95554734 95554784 5S 346 + 95554734 95554784 0 1 50 0 +chr1 100271938 100272091 SSU-rRNA_Hsa 284 + 100271938 100272091 0 1 153 0 +chr1 105973697 105973741 5S 268 + 105973697 105973741 0 1 44 0 +chr1 108113071 108113633 LSU-rRNA_Hsa 3656 - 108113071 108113633 0 1 562 0 +chr1 108113652 108113729 LSU-rRNA_Hsa 474 - 108113652 108113729 0 1 77 0 +chr1 109786180 109786293 LSU-rRNA_Hsa 295 + 109786180 109786293 0 1 113 0 +chr1 110120223 110120297 5S 305 + 110120223 110120297 0 1 74 0 +chr1 111584455 111584545 5S 605 + 111584455 111584545 0 1 90 0 +chr1 117504996 117505074 5S 552 - 117504996 117505074 0 1 78 0 +chr1 118807024 118807112 5S 562 - 118807024 118807112 0 1 88 0 +chr1 120543883 120544125 LSU-rRNA_Hsa 1648 - 120543883 120544125 0 1 242 0 +chr1 121153238 121153279 5S 247 - 121153238 121153279 0 1 41 0 +chr1 144935533 144935575 5S 256 + 144935533 144935575 0 1 42 0 +chr1 145277249 145277491 LSU-rRNA_Hsa 1702 + 145277249 145277491 0 1 242 0 +chr1 145606862 145606916 5S 355 - 145606862 145606916 0 1 54 0 +chr1 146124157 146124246 5S 647 + 146124157 146124246 0 1 89 0 +chr1 147665989 147666078 5S 692 + 147665989 147666078 0 1 89 0 +chr1 148913293 148913380 5S 622 - 148913293 148913380 0 1 87 0 +chr1 150239193 150239284 LSU-rRNA_Hsa 233 - 150239193 150239284 0 1 91 0 +chr1 153874351 153874393 5S 290 + 153874351 153874393 0 1 42 0 +chr1 153911261 153911303 5S 284 + 153911261 153911303 0 1 42 0 +chr1 157139812 157139887 LSU-rRNA_Hsa 566 + 157139812 157139887 0 1 75 0 +chr1 159148262 159148352 5S 587 + 159148262 159148352 0 1 90 0 +chr1 160145608 160145659 5S 261 - 160145608 160145659 0 1 51 0 +chr1 162308432 162308512 5S 442 + 162308432 162308512 0 1 80 0 +chr1 163438305 163438395 5S 646 - 163438305 163438395 0 1 90 0 +chr1 163479273 163479362 5S 578 + 163479273 163479362 0 1 89 0 +chr1 164838402 164838442 5S 295 + 164838402 164838442 0 1 40 0 +chr1 166011480 166011587 5S 621 + 166011480 166011587 0 1 107 0 +chr1 166640296 166640359 LSU-rRNA_Hsa 448 + 166640296 166640359 0 1 63 0 +chr1 166975195 166975316 5S 893 + 166975195 166975316 0 1 121 0 +chr1 168795896 168796039 SSU-rRNA_Hsa 287 + 168795896 168796039 0 1 143 0 +chr1 169036501 169036578 5S 436 + 169036501 169036578 0 1 77 0 +chr1 169878691 169878920 LSU-rRNA_Hsa 1288 - 169878691 169878920 0 1 229 0 +chr1 171682580 171682622 5S 346 - 171682580 171682622 0 1 42 0 +chr1 173690784 173690945 LSU-rRNA_Hsa 529 + 173690784 173690945 0 1 161 0 +chr1 173890207 173890285 5S 459 + 173890207 173890285 0 1 78 0 +chr1 173938453 173938574 5S 811 - 173938453 173938574 0 1 121 0 +chr1 174734418 174734460 5S 317 + 174734418 174734460 0 1 42 0 +chr1 175662837 175662882 5S 272 + 175662837 175662882 0 1 45 0 +chr1 176951665 176951709 5S 240 + 176951665 176951709 0 1 44 0 +chr1 178530047 178530136 5S 666 + 178530047 178530136 0 1 89 0 +chr1 181740701 181740791 5S 635 + 181740701 181740791 0 1 90 0 +chr1 182181587 182181637 LSU-rRNA_Hsa 390 - 182181587 182181637 0 1 50 0 +chr1 182913539 182913624 5S 656 - 182913539 182913624 0 1 85 0 +chr1 184984080 184984199 5S 780 - 184984080 184984199 0 1 119 0 +chr1 186341759 186341849 5S 629 + 186341759 186341849 0 1 90 0 +chr1 189635306 189635385 5S 465 - 189635306 189635385 0 1 79 0 +chr1 189747044 189747089 5S 266 - 189747044 189747089 0 1 45 0 +chr1 192939927 192939968 5S 290 + 192939927 192939968 0 1 41 0 +chr1 198053630 198053669 5S 312 + 198053630 198053669 0 1 39 0 +chr1 200428778 200428912 LSU-rRNA_Hsa 266 - 200428778 200428912 0 1 134 0 +chr1 204531538 204531649 5S 880 - 204531538 204531649 0 1 111 0 +chr1 204676468 204676556 5S 498 - 204676468 204676556 0 1 88 0 +chr1 207359637 207359689 5S 334 + 207359637 207359689 0 1 52 0 +chr1 207675730 207675772 5S 262 - 207675730 207675772 0 1 42 0 +chr1 207714085 207714135 5S 353 - 207714085 207714135 0 1 50 0 +chr1 207732642 207732692 5S 353 - 207732642 207732692 0 1 50 0 +chr1 207749693 207749743 5S 373 - 207749693 207749743 0 1 50 0 +chr1 207848678 207848721 5S 309 - 207848678 207848721 0 1 43 0 +chr1 207882275 207882325 5S 345 - 207882275 207882325 0 1 50 0 +chr1 208003650 208003776 5S 412 - 208003650 208003776 0 1 126 0 +chr1 208763874 208763978 5S 313 + 208763874 208763978 0 1 104 0 +chr1 211799052 211799116 LSU-rRNA_Hsa 383 - 211799052 211799116 0 1 64 0 +chr1 211799883 211800066 LSU-rRNA_Hsa 383 - 211799883 211800066 0 1 183 0 +chr1 219836016 219836058 5S 282 + 219836016 219836058 0 1 42 0 +chr1 219935130 219935215 5S 541 + 219935130 219935215 0 1 85 0 +chr1 222522768 222522879 LSU-rRNA_Hsa 566 + 222522768 222522879 0 1 111 0 +chr1 222869880 222869970 5S 592 - 222869880 222869970 0 1 90 0 +chr1 224850903 224850959 5S 278 - 224850903 224850959 0 1 56 0 +chr1 225449612 225449652 5S 255 + 225449612 225449652 0 1 40 0 +chr1 226655843 226655885 5S 256 - 226655843 226655885 0 1 42 0 +chr1 227748881 227749003 5S 902 + 227748881 227749003 0 1 122 0 +chr1 228743493 228743604 5S 830 + 228743493 228743604 0 1 111 0 +chr1 228746012 228746133 5S 1125 - 228746012 228746133 0 1 121 0 +chr1 228748253 228748374 5S 1125 - 228748253 228748374 0 1 121 0 +chr1 228750494 228750615 5S 1125 - 228750494 228750615 0 1 121 0 +chr1 228752735 228752856 5S 1125 - 228752735 228752856 0 1 121 0 +chr1 228754976 228755097 5S 1125 - 228754976 228755097 0 1 121 0 +chr1 228757191 228757312 5S 1125 - 228757191 228757312 0 1 121 0 +chr1 228759411 228759532 5S 1125 - 228759411 228759532 0 1 121 0 +chr1 228761653 228761774 5S 1125 - 228761653 228761774 0 1 121 0 +chr1 228763892 228764013 5S 1109 - 228763892 228764013 0 1 121 0 +chr1 228766134 228766255 5S 1125 - 228766134 228766255 0 1 121 0 +chr1 228768375 228768496 5S 1125 - 228768375 228768496 0 1 121 0 +chr1 228770615 228770736 5S 1125 - 228770615 228770736 0 1 121 0 +chr1 228772840 228772961 5S 1125 - 228772840 228772961 0 1 121 0 +chr1 228775081 228775202 5S 1125 - 228775081 228775202 0 1 121 0 +chr1 228777312 228777433 5S 1125 - 228777312 228777433 0 1 121 0 +chr1 228779553 228779674 5S 1117 - 228779553 228779674 0 1 121 0 +chr1 228781784 228781905 5S 1117 - 228781784 228781905 0 1 121 0 +chr1 228783657 228783779 5S 515 - 228783657 228783779 0 1 122 0 +chr1 229685651 229685771 5S 785 + 229685651 229685771 0 1 120 0 +chr1 230955995 230956106 5S 735 + 230955995 230956106 0 1 111 0 +chr1 231417193 231417274 5S 366 - 231417193 231417274 0 1 81 0 +chr1 231510065 231510258 LSU-rRNA_Hsa 790 - 231510065 231510258 0 1 193 0 +chr1 234436991 234437029 5S 266 - 234436991 234437029 0 1 38 0 +chr1 237766308 237766764 LSU-rRNA_Hsa 3134 + 237766308 237766764 0 1 456 0 +chr1 237980427 237980466 5S 231 + 237980427 237980466 0 1 39 0 +chr1 238839887 238839937 5S 377 - 238839887 238839937 0 1 50 0 +chr1 239864162 239864201 5S 240 + 239864162 239864201 0 1 39 0 +chr1 242108860 242108991 LSU-rRNA_Hsa 263 - 242108860 242108991 0 1 131 0 +chr1 242118382 242118420 5S 290 + 242118382 242118420 0 1 38 0 +chr1 242297573 242297684 5S 530 + 242297573 242297684 0 1 111 0 +chr1 247367869 247367963 5S 564 - 247367869 247367963 0 1 94 0 +chr2 133036250 133039236 LSU-rRNA_Hsa 8972 - 133036250 133039236 0 1 2986 0 +chr2 2741842 2741884 5S 272 + 2741842 2741884 0 1 42 0 +chr2 11657523 11657630 5S 520 + 11657523 11657630 0 1 107 0 +chr2 11701790 11701905 5S 891 - 11701790 11701905 0 1 115 0 +chr2 12185872 12185914 5S 289 - 12185872 12185914 0 1 42 0 +chr2 15671492 15671542 5S 294 + 15671492 15671542 0 1 50 0 +chr2 20486646 20486688 5S 286 + 20486646 20486688 0 1 42 0 +chr2 20601397 20601485 5S 724 - 20601397 20601485 0 1 88 0 +chr2 22561757 22561875 5S 742 - 22561757 22561875 0 1 118 0 +chr2 22875571 22875621 5S 326 - 22875571 22875621 0 1 50 0 +chr2 24587368 24587413 LSU-rRNA_Hsa 301 + 24587368 24587413 0 1 45 0 +chr2 24587505 24587639 LSU-rRNA_Hsa 817 + 24587505 24587639 0 1 134 0 +chr2 24787496 24787607 5S 659 - 24787496 24787607 0 1 111 0 +chr2 26794601 26794643 5S 333 - 26794601 26794643 0 1 42 0 +chr2 28124570 28124612 5S 303 + 28124570 28124612 0 1 42 0 +chr2 28780915 28780958 5S 250 - 28780915 28780958 0 1 43 0 +chr2 28906841 28906922 5S 469 + 28906841 28906922 0 1 81 0 +chr2 31451177 31451268 5S 522 + 31451177 31451268 0 1 91 0 +chr2 32342390 32342531 LSU-rRNA_Hsa 621 + 32342390 32342531 0 1 141 0 +chr2 33069210 33069275 SSU-rRNA_Hsa 295 + 33069210 33069275 0 1 65 0 +chr2 33459429 33459471 5S 318 - 33459429 33459471 0 1 42 0 +chr2 33510865 33510954 5S 572 - 33510865 33510954 0 1 89 0 +chr2 33557964 33558051 5S 506 + 33557964 33558051 0 1 87 0 +chr2 35082718 35082761 5S 264 - 35082718 35082761 0 1 43 0 +chr2 37305250 37305308 SSU-rRNA_Hsa 324 + 37305250 37305308 0 1 58 0 +chr2 37544940 37545030 5S 586 - 37544940 37545030 0 1 90 0 +chr2 45093024 45093066 5S 235 - 45093024 45093066 0 1 42 0 +chr2 47414070 47414109 5S 284 + 47414070 47414109 0 1 39 0 +chr2 48569825 48569867 5S 284 + 48569825 48569867 0 1 42 0 +chr2 50196804 50196894 5S 668 - 50196804 50196894 0 1 90 0 +chr2 54071030 54071113 LSU-rRNA_Hsa 321 + 54071030 54071113 0 1 83 0 +chr2 54173550 54173592 5S 321 + 54173550 54173592 0 1 42 0 +chr2 56462366 56462465 5S 615 - 56462366 56462465 0 1 99 0 +chr2 59549314 59549403 5S 764 + 59549314 59549403 0 1 89 0 +chr2 59830730 59830959 LSU-rRNA_Hsa 1440 - 59830730 59830959 0 1 229 0 +chr2 59921896 59921986 5S 537 + 59921896 59921986 0 1 90 0 +chr2 61225886 61225973 5S 570 + 61225886 61225973 0 1 87 0 +chr2 61892492 61892559 LSU-rRNA_Hsa 466 + 61892492 61892559 0 1 67 0 +chr2 63435926 63436321 LSU-rRNA_Hsa 2106 - 63435926 63436321 0 1 395 0 +chr2 63436375 63436640 LSU-rRNA_Hsa 2106 - 63436375 63436640 0 1 265 0 +chr2 63997342 63997384 5S 278 + 63997342 63997384 0 1 42 0 +chr2 65103096 65103154 LSU-rRNA_Hsa 457 - 65103096 65103154 0 1 58 0 +chr2 69409055 69409135 5S 382 - 69409055 69409135 0 1 80 0 +chr2 72489594 72489645 5S 351 + 72489594 72489645 0 1 51 0 +chr2 73854005 73854061 5S 374 - 73854005 73854061 0 1 56 0 +chr2 73914344 73914400 5S 437 - 73914344 73914400 0 1 56 0 +chr2 74195244 74195332 5S 603 - 74195244 74195332 0 1 88 0 +chr2 77000034 77000127 5S 644 + 77000034 77000127 0 1 93 0 +chr2 78928721 78928992 LSU-rRNA_Hsa 1498 + 78928721 78928992 0 1 271 0 +chr2 81723361 81723451 5S 752 - 81723361 81723451 0 1 90 0 +chr2 87792129 87792174 LSU-rRNA_Hsa 230 + 87792129 87792174 0 1 45 0 +chr2 91862884 91862971 5S 622 + 91862884 91862971 0 1 87 0 +chr2 97622462 97622552 5S 515 - 97622462 97622552 0 1 90 0 +chr2 97969897 97970003 5S 231 - 97969897 97970003 0 1 106 0 +chr2 98068892 98068998 5S 231 + 98068892 98068998 0 1 106 0 +chr2 99208676 99208752 LSU-rRNA_Hsa 282 - 99208676 99208752 0 1 76 0 +chr2 101021027 101021064 5S 237 - 101021027 101021064 0 1 37 0 +chr2 101169113 101169152 5S 290 - 101169113 101169152 0 1 39 0 +chr2 112215147 112215192 LSU-rRNA_Hsa 230 - 112215147 112215192 0 1 45 0 +chr2 115075274 115075316 5S 298 - 115075274 115075316 0 1 42 0 +chr2 115585779 115585822 5S 289 + 115585779 115585822 0 1 43 0 +chr2 115695017 115695281 LSU-rRNA_Hsa 1531 - 115695017 115695281 0 1 264 0 +chr2 115695291 115695382 5S 692 + 115695291 115695382 0 1 91 0 +chr2 116509735 116509792 5S 370 - 116509735 116509792 0 1 57 0 +chr2 117000315 117000353 5S 293 + 117000315 117000353 0 1 38 0 +chr2 117780779 117780925 LSU-rRNA_Hsa 248 + 117780779 117780925 0 1 146 0 +chr2 118649524 118649562 5S 271 + 118649524 118649562 0 1 38 0 +chr2 121836197 121836528 SSU-rRNA_Hsa 625 + 121836197 121836528 0 1 331 0 +chr2 122557538 122557581 5S 296 - 122557538 122557581 0 1 43 0 +chr2 125690491 125690570 5S 417 + 125690491 125690570 0 1 79 0 +chr2 128049143 128049383 LSU-rRNA_Hsa 1016 - 128049143 128049383 0 1 240 0 +chr2 128049406 128049488 LSU-rRNA_Hsa 619 - 128049406 128049488 0 1 82 0 +chr2 128049840 128049865 LSU-rRNA_Hsa 619 - 128049840 128049865 0 1 25 0 +chr2 129202652 129202766 5S 828 - 129202652 129202766 0 1 114 0 +chr2 131584240 131584291 5S 349 - 131584240 131584291 0 1 51 0 +chr2 133011919 133013768 SSU-rRNA_Hsa 14662 - 133011919 133013768 0 1 1849 0 +chr2 134988766 134988855 5S 532 + 134988766 134988855 0 1 89 0 +chr2 137621042 137621086 5S 261 + 137621042 137621086 0 1 44 0 +chr2 138269694 138269782 5S 651 - 138269694 138269782 0 1 88 0 +chr2 140490230 140490272 5S 295 - 140490230 140490272 0 1 42 0 +chr2 143438000 143438042 5S 272 - 143438000 143438042 0 1 42 0 +chr2 146930831 146930974 LSU-rRNA_Hsa 282 - 146930831 146930974 0 1 143 0 +chr2 148471043 148471123 5S 545 - 148471043 148471123 0 1 80 0 +chr2 149225075 149225116 5S 231 + 149225075 149225116 0 1 41 0 +chr2 155446921 155447020 5S 553 + 155446921 155447020 0 1 99 0 +chr2 159305914 159305962 5S 272 - 159305914 159305962 0 1 48 0 +chr2 159306260 159306314 5S 272 - 159306260 159306314 0 1 54 0 +chr2 159440391 159440797 LSU-rRNA_Hsa 2230 - 159440391 159440797 0 1 406 0 +chr2 160450395 160450460 5S 374 - 160450395 160450460 0 1 65 0 +chr2 160870909 160870951 5S 292 + 160870909 160870951 0 1 42 0 +chr2 161511254 161511291 5S 247 - 161511254 161511291 0 1 37 0 +chr2 163353446 163353535 5S 561 + 163353446 163353535 0 1 89 0 +chr2 163574714 163574757 5S 299 - 163574714 163574757 0 1 43 0 +chr2 165006663 165006706 5S 245 + 165006663 165006706 0 1 43 0 +chr2 165006717 165006760 5S 245 + 165006717 165006760 0 1 43 0 +chr2 165714941 165715049 5S 605 + 165714941 165715049 0 1 108 0 +chr2 165752197 165752287 5S 632 - 165752197 165752287 0 1 90 0 +chr2 170199912 170199999 LSU-rRNA_Hsa 344 - 170199912 170199999 0 1 87 0 +chr2 178003429 178003531 5S 460 + 178003429 178003531 0 1 102 0 +chr2 182913548 182913639 5S 597 + 182913548 182913639 0 1 91 0 +chr2 183356378 183356418 5S 237 + 183356378 183356418 0 1 40 0 +chr2 189141482 189141571 5S 665 - 189141482 189141571 0 1 89 0 +chr2 191402647 191402786 LSU-rRNA_Hsa 1031 - 191402647 191402786 0 1 139 0 +chr2 194384036 194384085 5S 241 - 194384036 194384085 0 1 49 0 +chr2 195208716 195208758 5S 228 + 195208716 195208758 0 1 42 0 +chr2 195594418 195594460 5S 300 + 195594418 195594460 0 1 42 0 +chr2 198025423 198025538 5S 271 + 198025423 198025538 0 1 115 0 +chr2 198781606 198781650 5S 261 - 198781606 198781650 0 1 44 0 +chr2 199466270 199466312 5S 326 + 199466270 199466312 0 1 42 0 +chr2 201124402 201124517 SSU-rRNA_Hsa 289 + 201124402 201124517 0 1 115 0 +chr2 201713765 201713867 5S 510 - 201713765 201713867 0 1 102 0 +chr2 202793903 202793943 5S 278 + 202793903 202793943 0 1 40 0 +chr2 203210988 203211097 LSU-rRNA_Hsa 929 - 203210988 203211097 0 1 109 0 +chr2 208918884 208918981 5S 588 - 208918884 208918981 0 1 97 0 +chr2 209785268 209785388 5S 787 - 209785268 209785388 0 1 120 0 +chr2 209830233 209830280 5S 245 - 209830233 209830280 0 1 47 0 +chr2 210437186 210437281 LSU-rRNA_Hsa 248 + 210437186 210437281 0 1 95 0 +chr2 210586655 210586744 5S 548 - 210586655 210586744 0 1 89 0 +chr2 212014594 212014719 LSU-rRNA_Hsa 249 + 212014594 212014719 0 1 125 0 +chr2 212400377 212400467 5S 744 + 212400377 212400467 0 1 90 0 +chr2 214122836 214122884 5S 248 + 214122836 214122884 0 1 48 0 +chr2 214365737 214365846 5S 491 - 214365737 214365846 0 1 109 0 +chr2 214637026 214637102 5S 509 + 214637026 214637102 0 1 76 0 +chr2 215572056 215572098 5S 266 - 215572056 215572098 0 1 42 0 +chr2 217658239 217658323 5S 511 - 217658239 217658323 0 1 84 0 +chr2 223100342 223100493 LSU-rRNA_Hsa 971 + 223100342 223100493 0 1 151 0 +chr2 225887043 225887126 SSU-rRNA_Hsa 292 - 225887043 225887126 0 1 83 0 +chr2 228627779 228627868 5S 546 - 228627779 228627868 0 1 89 0 +chr2 229460926 229460968 5S 318 + 229460926 229460968 0 1 42 0 +chr2 230015752 230015823 LSU-rRNA_Hsa 489 + 230015752 230015823 0 1 71 0 +chr2 230045487 230045638 LSU-rRNA_Hsa 1083 - 230045487 230045638 0 1 151 0 +chr2 230045630 230045734 LSU-rRNA_Hsa 796 - 230045630 230045734 0 1 104 0 +chr2 232110067 232110184 LSU-rRNA_Hsa 534 + 232110067 232110184 0 1 117 0 +chr2 232687134 232687177 5S 233 + 232687134 232687177 0 1 43 0 +chr2 235098241 235098283 5S 325 + 235098241 235098283 0 1 42 0 +chr2 235935599 235935642 5S 265 - 235935599 235935642 0 1 43 0 +chr2 242524382 242524472 5S 715 + 242524382 242524472 0 1 90 0 +chr3 5066428 5066480 5S 280 + 5066428 5066480 0 1 52 0 +chr3 9175952 9176057 LSU-rRNA_Hsa 378 - 9175952 9176057 0 1 105 0 +chr3 12196530 12196571 5S 359 - 12196530 12196571 0 1 41 0 +chr3 12368310 12368352 5S 319 - 12368310 12368352 0 1 42 0 +chr3 12552592 12552710 5S 832 - 12552592 12552710 0 1 118 0 +chr3 14436147 14436259 5S 790 + 14436147 14436259 0 1 112 0 +chr3 15345124 15345190 LSU-rRNA_Hsa 535 + 15345124 15345190 0 1 66 0 +chr3 18189730 18189770 5S 257 + 18189730 18189770 0 1 40 0 +chr3 18271202 18271389 LSU-rRNA_Hsa 234 + 18271202 18271389 0 1 187 0 +chr3 19867443 19867485 5S 245 + 19867443 19867485 0 1 42 0 +chr3 21507508 21507551 5S 251 + 21507508 21507551 0 1 43 0 +chr3 22904996 22905109 LSU-rRNA_Hsa 285 - 22904996 22905109 0 1 113 0 +chr3 23768083 23768153 LSU-rRNA_Hsa 393 + 23768083 23768153 0 1 70 0 +chr3 24063078 24063140 LSU-rRNA_Hsa 370 + 24063078 24063140 0 1 62 0 +chr3 25066497 25066584 5S 675 + 25066497 25066584 0 1 87 0 +chr3 25393783 25393883 5S 591 - 25393783 25393883 0 1 100 0 +chr3 27558844 27558889 5S 287 + 27558844 27558889 0 1 45 0 +chr3 27889216 27889362 SSU-rRNA_Hsa 357 - 27889216 27889362 0 1 146 0 +chr3 28124760 28124802 5S 309 - 28124760 28124802 0 1 42 0 +chr3 29899236 29899297 5S 365 - 29899236 29899297 0 1 61 0 +chr3 30072742 30072787 5S 281 - 30072742 30072787 0 1 45 0 +chr3 31270206 31270295 5S 679 + 31270206 31270295 0 1 89 0 +chr3 33533500 33533590 5S 582 - 33533500 33533590 0 1 90 0 +chr3 37383139 37383229 5S 654 + 37383139 37383229 0 1 90 0 +chr3 41426019 41426069 5S 324 - 41426019 41426069 0 1 50 0 +chr3 44364160 44364196 5S 237 - 44364160 44364196 0 1 36 0 +chr3 45494767 45494852 LSU-rRNA_Hsa 488 - 45494767 45494852 0 1 85 0 +chr3 46499883 46499939 5S 397 - 46499883 46499939 0 1 56 0 +chr3 46693773 46693815 5S 234 + 46693773 46693815 0 1 42 0 +chr3 48789984 48790025 5S 262 + 48789984 48790025 0 1 41 0 +chr3 49113651 49113955 LSU-rRNA_Hsa 1211 + 49113651 49113955 0 1 304 0 +chr3 49448636 49448677 5S 297 - 49448636 49448677 0 1 41 0 +chr3 49450185 49450251 5S 300 + 49450185 49450251 0 1 66 0 +chr3 49504577 49504664 5S 657 - 49504577 49504664 0 1 87 0 +chr3 49987456 49987902 SSU-rRNA_Hsa 1962 + 49987456 49987902 0 1 446 0 +chr3 50457212 50457332 5S 817 + 50457212 50457332 0 1 120 0 +chr3 50561992 50562034 5S 279 + 50561992 50562034 0 1 42 0 +chr3 50795938 50795979 5S 321 + 50795938 50795979 0 1 41 0 +chr3 51728478 51728598 5S 948 - 51728478 51728598 0 1 120 0 +chr3 56219153 56219252 5S 567 + 56219153 56219252 0 1 99 0 +chr3 57799850 57799910 LSU-rRNA_Hsa 362 - 57799850 57799910 0 1 60 0 +chr3 61068547 61068637 5S 673 - 61068547 61068637 0 1 90 0 +chr3 61618205 61618247 5S 316 - 61618205 61618247 0 1 42 0 +chr3 63531115 63531196 5S 567 + 63531115 63531196 0 1 81 0 +chr3 67884829 67884960 LSU-rRNA_Hsa 775 - 67884829 67884960 0 1 131 0 +chr3 68932118 68932196 5S 413 + 68932118 68932196 0 1 78 0 +chr3 69280184 69280280 5S 606 + 69280184 69280280 0 1 96 0 +chr3 72740873 72740962 5S 617 - 72740873 72740962 0 1 89 0 +chr3 72794947 72794987 5S 329 + 72794947 72794987 0 1 40 0 +chr3 79159065 79159105 SSU-rRNA_Hsa 270 + 79159065 79159105 0 1 40 0 +chr3 79836882 79836967 5S 336 + 79836882 79836967 0 1 85 0 +chr3 84169349 84169453 LSU-rRNA_Hsa 344 + 84169349 84169453 0 1 104 0 +chr3 94237957 94237999 5S 326 - 94237957 94237999 0 1 42 0 +chr3 100139011 100139065 5S 326 - 100139011 100139065 0 1 54 0 +chr3 106556112 106556158 5S 274 - 106556112 106556158 0 1 46 0 +chr3 108250093 108250368 LSU-rRNA_Hsa 1627 + 108250093 108250368 0 1 275 0 +chr3 114168591 114168643 5S 235 - 114168591 114168643 0 1 52 0 +chr3 117985769 117985855 LSU-rRNA_Hsa 515 + 117985769 117985855 0 1 86 0 +chr3 119248242 119248323 LSU-rRNA_Hsa 648 + 119248242 119248323 0 1 81 0 +chr3 121460313 121460355 5S 302 + 121460313 121460355 0 1 42 0 +chr3 121809468 121809516 5S 270 + 121809468 121809516 0 1 48 0 +chr3 122734688 122734816 LSU-rRNA_Hsa 400 - 122734688 122734816 0 1 128 0 +chr3 124777192 124777282 5S 587 - 124777192 124777282 0 1 90 0 +chr3 125058700 125058742 5S 353 - 125058700 125058742 0 1 42 0 +chr3 126283431 126283520 5S 687 - 126283431 126283520 0 1 89 0 +chr3 127682450 127682540 5S 684 + 127682450 127682540 0 1 90 0 +chr3 129639058 129639101 5S 256 + 129639058 129639101 0 1 43 0 +chr3 131136687 131136842 SSU-rRNA_Hsa 784 - 131136687 131136842 0 1 155 0 +chr3 133204694 133204762 5S 508 - 133204694 133204762 0 1 68 0 +chr3 133205073 133205106 5S 508 - 133205073 133205106 0 1 33 0 +chr3 133428929 133429019 5S 733 - 133428929 133429019 0 1 90 0 +chr3 134502307 134502397 5S 824 - 134502307 134502397 0 1 90 0 +chr3 136249261 136249310 5S 370 - 136249261 136249310 0 1 49 0 +chr3 137237007 137237097 5S 564 - 137237007 137237097 0 1 90 0 +chr3 138428412 138428491 SSU-rRNA_Hsa 250 + 138428412 138428491 0 1 79 0 +chr3 138801287 138801365 LSU-rRNA_Hsa 410 - 138801287 138801365 0 1 78 0 +chr3 141772469 141772534 LSU-rRNA_Hsa 289 + 141772469 141772534 0 1 65 0 +chr3 141773744 141774230 LSU-rRNA_Hsa 1417 + 141773744 141774230 0 1 486 0 +chr3 142099316 142099354 5S 306 - 142099316 142099354 0 1 38 0 +chr3 142310543 142310633 5S 683 - 142310543 142310633 0 1 90 0 +chr3 142384658 142384747 LSU-rRNA_Hsa 665 - 142384658 142384747 0 1 89 0 +chr3 143905745 143905862 5S 549 - 143905745 143905862 0 1 117 0 +chr3 144942633 144942676 5S 343 + 144942633 144942676 0 1 43 0 +chr3 148368424 148368544 LSU-rRNA_Hsa 510 + 148368424 148368544 0 1 120 0 +chr3 149036455 149036551 5S 344 - 149036455 149036551 0 1 96 0 +chr3 150905885 150905971 5S 735 + 150905885 150905971 0 1 86 0 +chr3 155093795 155093838 5S 302 - 155093795 155093838 0 1 43 0 +chr3 155824012 155824051 5S 290 - 155824012 155824051 0 1 39 0 +chr3 156891704 156891829 5S 686 - 156891704 156891829 0 1 125 0 +chr3 158564366 158564446 5S 528 - 158564366 158564446 0 1 80 0 +chr3 158700751 158700798 LSU-rRNA_Hsa 268 + 158700751 158700798 0 1 47 0 +chr3 160146210 160146313 LSU-rRNA_Hsa 314 + 160146210 160146313 0 1 103 0 +chr3 160436226 160436311 5S 521 + 160436226 160436311 0 1 85 0 +chr3 166226613 166226675 5S 253 - 166226613 166226675 0 1 62 0 +chr3 169341333 169341375 5S 284 + 169341333 169341375 0 1 42 0 +chr3 172729250 172729288 5S 269 - 172729250 172729288 0 1 38 0 +chr3 173846978 173847080 LSU-rRNA_Hsa 257 + 173846978 173847080 0 1 102 0 +chr3 176481016 176481101 5S 554 + 176481016 176481101 0 1 85 0 +chr3 177029542 177029583 5S 251 - 177029542 177029583 0 1 41 0 +chr3 178146987 178147077 5S 562 - 178146987 178147077 0 1 90 0 +chr3 179069096 179069138 5S 266 - 179069096 179069138 0 1 42 0 +chr3 179497343 179497506 LSU-rRNA_Hsa 1089 + 179497343 179497506 0 1 163 0 +chr3 179879674 179879765 5S 791 - 179879674 179879765 0 1 91 0 +chr3 181540658 181540778 5S 1053 - 181540658 181540778 0 1 120 0 +chr3 182976114 182976204 5S 654 - 182976114 182976204 0 1 90 0 +chr3 185178987 185179029 5S 303 - 185178987 185179029 0 1 42 0 +chr3 185841107 185841148 5S 247 - 185841107 185841148 0 1 41 0 +chr3 185971408 185971489 5S 403 + 185971408 185971489 0 1 81 0 +chr3 188637947 188637989 5S 325 - 188637947 188637989 0 1 42 0 +chr3 189265665 189265708 5S 265 - 189265665 189265708 0 1 43 0 +chr3 192406338 192406389 5S 352 + 192406338 192406389 0 1 51 0 +chr3 194194315 194194368 5S 339 + 194194315 194194368 0 1 53 0 +chr3 195903749 195903797 LSU-rRNA_Hsa 310 - 195903749 195903797 0 1 48 0 +chr3 197084627 197084679 5S 349 - 197084627 197084679 0 1 52 0 +chr4 4346865 4346907 5S 263 - 4346865 4346907 0 1 42 0 +chr4 7584186 7584364 LSU-rRNA_Hsa 1410 + 7584186 7584364 0 1 178 0 +chr4 8394741 8394853 5S 762 + 8394741 8394853 0 1 112 0 +chr4 9412928 9412979 5S 301 - 9412928 9412979 0 1 51 0 +chr4 9794395 9794483 5S 581 - 9794395 9794483 0 1 88 0 +chr4 10117418 10117508 5S 599 - 10117418 10117508 0 1 90 0 +chr4 10563335 10563458 LSU-rRNA_Hsa 349 + 10563335 10563458 0 1 123 0 +chr4 11415672 11415784 5S 480 - 11415672 11415784 0 1 112 0 +chr4 13726257 13726295 5S 250 + 13726257 13726295 0 1 38 0 +chr4 19183404 19183492 5S 503 - 19183404 19183492 0 1 88 0 +chr4 21720158 21720194 5S 264 + 21720158 21720194 0 1 36 0 +chr4 29529287 29529327 5S 267 - 29529287 29529327 0 1 40 0 +chr4 34853988 34854041 5S 280 - 34853988 34854041 0 1 53 0 +chr4 38760421 38760513 5S 336 - 38760421 38760513 0 1 92 0 +chr4 39938399 39938475 5S 325 + 39938399 39938475 0 1 76 0 +chr4 40533259 40533301 5S 245 - 40533259 40533301 0 1 42 0 +chr4 40992170 40992292 5S 786 + 40992170 40992292 0 1 122 0 +chr4 42585633 42585726 SSU-rRNA_Hsa 235 - 42585633 42585726 0 1 93 0 +chr4 56963556 56963645 5S 774 + 56963556 56963645 0 1 89 0 +chr4 57197330 57197402 5S 500 - 57197330 57197402 0 1 72 0 +chr4 68305710 68305769 5S 398 + 68305710 68305769 0 1 59 0 +chr4 68307765 68307832 5S 386 + 68307765 68307832 0 1 67 0 +chr4 70296581 70296753 LSU-rRNA_Hsa 1066 - 70296581 70296753 0 1 172 0 +chr4 72625242 72625333 5S 617 - 72625242 72625333 0 1 91 0 +chr4 74637232 74637276 5S 274 - 74637232 74637276 0 1 44 0 +chr4 74770162 74770252 5S 535 - 74770162 74770252 0 1 90 0 +chr4 76807175 76807697 LSU-rRNA_Hsa 3075 + 76807175 76807697 0 1 522 0 +chr4 77437020 77437175 LSU-rRNA_Hsa 315 + 77437020 77437175 0 1 155 0 +chr4 77683159 77683241 5S 463 + 77683159 77683241 0 1 82 0 +chr4 78129557 78129888 LSU-rRNA_Hsa 621 - 78129557 78129888 0 1 331 0 +chr4 78133450 78133550 LSU-rRNA_Hsa 328 - 78133450 78133550 0 1 100 0 +chr4 80796959 80797039 SSU-rRNA_Hsa 243 - 80796959 80797039 0 1 80 0 +chr4 86968241 86968396 LSU-rRNA_Hsa 987 - 86968241 86968396 0 1 155 0 +chr4 92185832 92185920 5S 568 - 92185832 92185920 0 1 88 0 +chr4 94741340 94741412 5S 492 + 94741340 94741412 0 1 72 0 +chr4 104086077 104086136 5S 302 - 104086077 104086136 0 1 59 0 +chr4 104665735 104665780 5S 301 + 104665735 104665780 0 1 45 0 +chr4 107924382 107924683 LSU-rRNA_Hsa 1351 - 107924382 107924683 0 1 301 0 +chr4 107924688 107924904 LSU-rRNA_Hsa 1301 - 107924688 107924904 0 1 216 0 +chr4 117220913 117221002 LSU-rRNA_Hsa 245 + 117220913 117221002 0 1 89 0 +chr4 120158524 120158690 LSU-rRNA_Hsa 1301 + 120158524 120158690 0 1 166 0 +chr4 123519825 123519876 5S 294 - 123519825 123519876 0 1 51 0 +chr4 124078770 124078821 5S 368 - 124078770 124078821 0 1 51 0 +chr4 126671578 126671636 5S 261 + 126671578 126671636 0 1 58 0 +chr4 131427823 131427930 5S 653 - 131427823 131427930 0 1 107 0 +chr4 134082914 134083021 LSU-rRNA_Hsa 723 - 134082914 134083021 0 1 107 0 +chr4 134709997 134710456 LSU-rRNA_Hsa 1724 + 134709997 134710456 0 1 459 0 +chr4 142170087 142170224 LSU-rRNA_Hsa 239 + 142170087 142170224 0 1 137 0 +chr4 147368337 147368387 5S 315 - 147368337 147368387 0 1 50 0 +chr4 148666495 148666568 5S 434 - 148666495 148666568 0 1 73 0 +chr4 149479098 149479189 5S 741 + 149479098 149479189 0 1 91 0 +chr4 150417016 150417184 SSU-rRNA_Hsa 306 + 150417016 150417184 0 1 168 0 +chr4 150769069 150769301 LSU-rRNA_Hsa 1148 + 150769069 150769301 0 1 232 0 +chr4 150828711 150828801 5S 653 + 150828711 150828801 0 1 90 0 +chr4 151323377 151323419 5S 270 - 151323377 151323419 0 1 42 0 +chr4 151694074 151694116 5S 263 + 151694074 151694116 0 1 42 0 +chr4 151888681 151888697 5S 516 - 151888681 151888697 0 1 16 0 +chr4 151891857 151891930 5S 516 - 151891857 151891930 0 1 73 0 +chr4 152892680 152892751 5S 520 - 152892680 152892751 0 1 71 0 +chr4 152893176 152893195 5S 520 - 152893176 152893195 0 1 19 0 +chr4 154159754 154159919 SSU-rRNA_Hsa 478 + 154159754 154159919 0 1 165 0 +chr4 155350335 155350399 LSU-rRNA_Hsa 430 + 155350335 155350399 0 1 64 0 +chr4 157366964 157367006 5S 228 - 157366964 157367006 0 1 42 0 +chr4 158934270 158934310 5S 243 + 158934270 158934310 0 1 40 0 +chr4 162202915 162202997 SSU-rRNA_Hsa 235 - 162202915 162202997 0 1 82 0 +chr4 166974339 166974445 5S 426 - 166974339 166974445 0 1 106 0 +chr4 167063724 167063863 LSU-rRNA_Hsa 764 + 167063724 167063863 0 1 139 0 +chr4 167064322 167064663 LSU-rRNA_Hsa 1190 + 167064322 167064663 0 1 341 0 +chr4 167839533 167839642 5S 565 - 167839533 167839642 0 1 109 0 +chr4 178378292 178378382 5S 671 - 178378292 178378382 0 1 90 0 +chr4 179327848 179327951 5S 659 + 179327848 179327951 0 1 103 0 +chr4 190936292 190936412 5S 719 + 190936292 190936412 0 1 120 0 +chr4 190938851 190938972 5S 802 + 190938851 190938972 0 1 121 0 +chr5 3353029 3353158 LSU-rRNA_Hsa 339 - 3353029 3353158 0 1 129 0 +chr5 6347719 6347754 5S 254 - 6347719 6347754 0 1 35 0 +chr5 6658790 6658850 5S 428 - 6658790 6658850 0 1 60 0 +chr5 6981947 6981989 5S 249 - 6981947 6981989 0 1 42 0 +chr5 6982037 6982079 5S 262 - 6982037 6982079 0 1 42 0 +chr5 6982182 6982224 5S 262 - 6982182 6982224 0 1 42 0 +chr5 7047339 7047450 5S 663 + 7047339 7047450 0 1 111 0 +chr5 9761018 9761107 5S 632 + 9761018 9761107 0 1 89 0 +chr5 10374041 10375088 SSU-rRNA_Hsa 3503 + 10374041 10375088 0 1 1047 0 +chr5 10376635 10376766 SSU-rRNA_Hsa 3503 + 10376635 10376766 0 1 131 0 +chr5 10376831 10377147 SSU-rRNA_Hsa 467 + 10376831 10377147 0 1 316 0 +chr5 14903460 14903502 5S 271 - 14903460 14903502 0 1 42 0 +chr5 16033376 16033464 5S 577 - 16033376 16033464 0 1 88 0 +chr5 16854102 16854196 5S 573 + 16854102 16854196 0 1 94 0 +chr5 17157100 17157182 5S 538 - 17157100 17157182 0 1 82 0 +chr5 25493346 25493376 5S 229 - 25493346 25493376 0 1 30 0 +chr5 33134900 33134950 5S 288 - 33134900 33134950 0 1 50 0 +chr5 33277966 33278059 5S 613 - 33277966 33278059 0 1 93 0 +chr5 34038377 34038545 LSU-rRNA_Hsa 908 + 34038377 34038545 0 1 168 0 +chr5 34802384 34802473 5S 757 + 34802384 34802473 0 1 89 0 +chr5 34862059 34862232 LSU-rRNA_Hsa 963 + 34862059 34862232 0 1 173 0 +chr5 35763126 35763168 5S 247 - 35763126 35763168 0 1 42 0 +chr5 36485446 36485534 5S 644 + 36485446 36485534 0 1 88 0 +chr5 38074926 38074969 5S 260 + 38074926 38074969 0 1 43 0 +chr5 39397629 39397706 5S 406 + 39397629 39397706 0 1 77 0 +chr5 41357103 41357192 SSU-rRNA_Hsa 311 - 41357103 41357192 0 1 89 0 +chr5 44638025 44638076 5S 358 + 44638025 44638076 0 1 51 0 +chr5 51182521 51182595 5S 374 + 51182521 51182595 0 1 74 0 +chr5 51813679 51813758 LSU-rRNA_Hsa 286 - 51813679 51813758 0 1 79 0 +chr5 52768689 52768745 LSU-rRNA_Hsa 273 + 52768689 52768745 0 1 56 0 +chr5 54480765 54480855 5S 697 - 54480765 54480855 0 1 90 0 +chr5 55073298 55073413 5S 920 + 55073298 55073413 0 1 115 0 +chr5 55442592 55442673 5S 475 - 55442592 55442673 0 1 81 0 +chr5 55556183 55556271 5S 578 - 55556183 55556271 0 1 88 0 +chr5 55939230 55939327 5S 308 + 55939230 55939327 0 1 97 0 +chr5 62110347 62110389 5S 234 - 62110347 62110389 0 1 42 0 +chr5 63691037 63691127 5S 687 - 63691037 63691127 0 1 90 0 +chr5 64014705 64014745 5S 283 - 64014705 64014745 0 1 40 0 +chr5 65424883 65425076 LSU-rRNA_Hsa 847 - 65424883 65425076 0 1 193 0 +chr5 65425079 65425229 LSU-rRNA_Hsa 903 - 65425079 65425229 0 1 150 0 +chr5 65472412 65472455 5S 280 - 65472412 65472455 0 1 43 0 +chr5 70788829 70788913 5S 322 - 70788829 70788913 0 1 84 0 +chr5 71146744 71146942 LSU-rRNA_Hsa 1590 + 71146744 71146942 0 1 198 0 +chr5 75387535 75387622 5S 472 - 75387535 75387622 0 1 87 0 +chr5 80743487 80743529 5S 331 - 80743487 80743529 0 1 42 0 +chr5 81058035 81058078 5S 291 - 81058035 81058078 0 1 43 0 +chr5 84142029 84142070 5S 276 + 84142029 84142070 0 1 41 0 +chr5 86258963 86259005 5S 333 - 86258963 86259005 0 1 42 0 +chr5 86259385 86259428 5S 333 - 86259385 86259428 0 1 43 0 +chr5 87514081 87514123 5S 252 - 87514081 87514123 0 1 42 0 +chr5 87570074 87570193 5S 702 - 87570074 87570193 0 1 119 0 +chr5 91196809 91196851 5S 304 - 91196809 91196851 0 1 42 0 +chr5 96724874 96725068 LSU-rRNA_Hsa 730 - 96724874 96725068 0 1 194 0 +chr5 97326426 97326479 5S 307 - 97326426 97326479 0 1 53 0 +chr5 97626409 97626460 5S 262 + 97626409 97626460 0 1 51 0 +chr5 99629459 99629502 5S 287 + 99629459 99629502 0 1 43 0 +chr5 101466755 101466845 5S 639 - 101466755 101466845 0 1 90 0 +chr5 103062073 103062216 LSU-rRNA_Hsa 370 + 103062073 103062216 0 1 143 0 +chr5 105258721 105258815 5S 576 - 105258721 105258815 0 1 94 0 +chr5 113734992 113735028 5S 229 - 113734992 113735028 0 1 36 0 +chr5 114480660 114480699 5S 266 + 114480660 114480699 0 1 39 0 +chr5 116153783 116153826 5S 356 + 116153783 116153826 0 1 43 0 +chr5 118112925 118112974 5S 259 + 118112925 118112974 0 1 49 0 +chr5 118408194 118408226 5S 231 + 118408194 118408226 0 1 32 0 +chr5 118781415 118781530 5S 729 + 118781415 118781530 0 1 115 0 +chr5 122990601 122991011 LSU-rRNA_Hsa 2777 + 122990601 122991011 0 1 410 0 +chr5 122991003 122991048 LSU-rRNA_Hsa 267 + 122991003 122991048 0 1 45 0 +chr5 129450095 129450185 5S 752 + 129450095 129450185 0 1 90 0 +chr5 132076634 132076676 5S 306 + 132076634 132076676 0 1 42 0 +chr5 132184268 132184358 5S 754 + 132184268 132184358 0 1 90 0 +chr5 136304903 136304993 5S 540 - 136304903 136304993 0 1 90 0 +chr5 137469192 137469234 5S 311 + 137469192 137469234 0 1 42 0 +chr5 137556191 137556233 5S 335 - 137556191 137556233 0 1 42 0 +chr5 138348018 138348109 5S 687 + 138348018 138348109 0 1 91 0 +chr5 138635541 138635650 5S 675 + 138635541 138635650 0 1 109 0 +chr5 139886780 139886830 5S 323 + 139886780 139886830 0 1 50 0 +chr5 140111671 140111759 5S 592 - 140111671 140111759 0 1 88 0 +chr5 141499847 141499888 5S 305 + 141499847 141499888 0 1 41 0 +chr5 145935545 145935667 LSU-rRNA_Hsa 891 + 145935545 145935667 0 1 122 0 +chr5 145965673 145965763 5S 558 - 145965673 145965763 0 1 90 0 +chr5 146800489 146800537 5S 350 - 146800489 146800537 0 1 48 0 +chr5 148430265 148430304 5S 293 + 148430265 148430304 0 1 39 0 +chr5 148853021 148853062 5S 328 + 148853021 148853062 0 1 41 0 +chr5 149327051 149327142 5S 368 - 149327051 149327142 0 1 91 0 +chr5 150306498 150306549 5S 376 + 150306498 150306549 0 1 51 0 +chr5 150857018 150857138 5S 716 - 150857018 150857138 0 1 120 0 +chr5 151255164 151255253 5S 723 - 151255164 151255253 0 1 89 0 +chr5 151517967 151518010 5S 306 - 151517967 151518010 0 1 43 0 +chr5 153715262 153715304 5S 274 + 153715262 153715304 0 1 42 0 +chr5 154788122 154788360 LSU-rRNA_Hsa 1569 + 154788122 154788360 0 1 238 0 +chr5 155272446 155272537 5S 783 + 155272446 155272537 0 1 91 0 +chr5 155511456 155511545 5S 545 - 155511456 155511545 0 1 89 0 +chr5 156626891 156627060 LSU-rRNA_Hsa 946 + 156626891 156627060 0 1 169 0 +chr5 157460233 157460281 5S 294 - 157460233 157460281 0 1 48 0 +chr5 162306975 162307001 5S 228 - 162306975 162307001 0 1 26 0 +chr5 162912212 162912253 5S 321 - 162912212 162912253 0 1 41 0 +chr5 166232505 166232557 5S 290 + 166232505 166232557 0 1 52 0 +chr5 167666588 167666651 5S 378 - 167666588 167666651 0 1 63 0 +chr5 172643260 172643310 5S 400 - 172643260 172643310 0 1 50 0 +chr5 172719536 172719626 5S 527 - 172719536 172719626 0 1 90 0 +chr5 174541742 174542177 SSU-rRNA_Hsa 3237 - 174541742 174542177 0 1 435 0 +chr6 3080072 3080131 5S 470 - 3080072 3080131 0 1 59 0 +chr6 3088953 3089043 5S 629 - 3088953 3089043 0 1 90 0 +chr6 4428196 4428316 5S 1123 + 4428196 4428316 0 1 120 0 +chr6 4436500 4436541 5S 262 - 4436500 4436541 0 1 41 0 +chr6 5830713 5830755 5S 317 - 5830713 5830755 0 1 42 0 +chr6 7776202 7776239 5S 257 + 7776202 7776239 0 1 37 0 +chr6 10753021 10753159 5S 645 - 10753021 10753159 0 1 138 0 +chr6 12390274 12390323 5S 297 + 12390274 12390323 0 1 49 0 +chr6 13988995 13989035 5S 270 + 13988995 13989035 0 1 40 0 +chr6 14404512 14404554 5S 320 - 14404512 14404554 0 1 42 0 +chr6 15035318 15035391 LSU-rRNA_Hsa 475 - 15035318 15035391 0 1 73 0 +chr6 15522462 15522531 5S 280 - 15522462 15522531 0 1 69 0 +chr6 16425488 16425551 LSU-rRNA_Hsa 284 - 16425488 16425551 0 1 63 0 +chr6 17722015 17722129 5S 795 - 17722015 17722129 0 1 114 0 +chr6 19438513 19438604 5S 693 + 19438513 19438604 0 1 91 0 +chr6 22691316 22691455 LSU-rRNA_Hsa 621 - 22691316 22691455 0 1 139 0 +chr6 22948193 22948350 LSU-rRNA_Hsa 895 - 22948193 22948350 0 1 157 0 +chr6 23008011 23008100 LSU-rRNA_Hsa 298 - 23008011 23008100 0 1 89 0 +chr6 23009068 23009147 LSU-rRNA_Hsa 334 + 23009068 23009147 0 1 79 0 +chr6 26263863 26263995 SSU-rRNA_Hsa 339 + 26263863 26263995 0 1 132 0 +chr6 26264599 26264681 SSU-rRNA_Hsa 339 + 26264599 26264681 0 1 82 0 +chr6 27740108 27740150 5S 347 - 27740108 27740150 0 1 42 0 +chr6 28124039 28124077 5S 256 - 28124039 28124077 0 1 38 0 +chr6 28169811 28169873 LSU-rRNA_Hsa 352 + 28169811 28169873 0 1 62 0 +chr6 29729916 29730463 LSU-rRNA_Hsa 305 - 29729916 29730463 0 1 547 0 +chr6 31193056 31193095 SSU-rRNA_Hsa 229 + 31193056 31193095 0 1 39 0 +chr6 31443154 31443337 LSU-rRNA_Hsa 233 + 31443154 31443337 0 1 183 0 +chr6 32046312 32046404 5S 563 - 32046312 32046404 0 1 92 0 +chr6 36532459 36532538 SSU-rRNA_Hsa 267 + 36532459 36532538 0 1 79 0 +chr6 37312721 37312759 5S 305 - 37312721 37312759 0 1 38 0 +chr6 37354366 37354568 LSU-rRNA_Hsa 256 + 37354366 37354568 0 1 202 0 +chr6 41207255 41207363 5S 565 - 41207255 41207363 0 1 108 0 +chr6 41892168 41892210 5S 266 - 41892168 41892210 0 1 42 0 +chr6 42555542 42555584 5S 335 + 42555542 42555584 0 1 42 0 +chr6 42609814 42609864 5S 323 - 42609814 42609864 0 1 50 0 +chr6 43385831 43385918 5S 621 + 43385831 43385918 0 1 87 0 +chr6 43625575 43625663 5S 539 + 43625575 43625663 0 1 88 0 +chr6 43720579 43720688 5S 622 + 43720579 43720688 0 1 109 0 +chr6 44945280 44945356 5S 385 + 44945280 44945356 0 1 76 0 +chr6 47074872 47074911 5S 266 - 47074872 47074911 0 1 39 0 +chr6 50980611 50980737 LSU-rRNA_Hsa 783 - 50980611 50980737 0 1 126 0 +chr6 52797771 52797812 5S 312 - 52797771 52797812 0 1 41 0 +chr6 66774989 66775079 5S 585 + 66774989 66775079 0 1 90 0 +chr6 67654499 67654585 LSU-rRNA_Hsa 306 - 67654499 67654585 0 1 86 0 +chr6 68177111 68177199 5S 545 - 68177111 68177199 0 1 88 0 +chr6 69693254 69693298 5S 273 + 69693254 69693298 0 1 44 0 +chr6 70183071 70183129 LSU-rRNA_Hsa 465 - 70183071 70183129 0 1 58 0 +chr6 74016137 74016190 LSU-rRNA_Hsa 231 - 74016137 74016190 0 1 53 0 +chr6 74185646 74185803 LSU-rRNA_Hsa 995 + 74185646 74185803 0 1 157 0 +chr6 74877801 74877856 LSU-rRNA_Hsa 269 + 74877801 74877856 0 1 55 0 +chr6 76574973 76575052 5S 540 - 76574973 76575052 0 1 79 0 +chr6 82260695 82260757 LSU-rRNA_Hsa 365 + 82260695 82260757 0 1 62 0 +chr6 82331917 82332016 5S 511 + 82331917 82332016 0 1 99 0 +chr6 84992858 84992930 SSU-rRNA_Hsa 249 + 84992858 84992930 0 1 72 0 +chr6 88348967 88349012 5S 266 - 88348967 88349012 0 1 45 0 +chr6 90961045 90961087 5S 284 - 90961045 90961087 0 1 42 0 +chr6 94774622 94774664 5S 305 - 94774622 94774664 0 1 42 0 +chr6 100029095 100029165 LSU-rRNA_Hsa 557 - 100029095 100029165 0 1 70 0 +chr6 104991145 104991189 5S 303 + 104991145 104991189 0 1 44 0 +chr6 105771976 105772035 LSU-rRNA_Hsa 292 + 105771976 105772035 0 1 59 0 +chr6 105967763 105967826 LSU-rRNA_Hsa 268 + 105967763 105967826 0 1 63 0 +chr6 106897253 106897338 5S 610 + 106897253 106897338 0 1 85 0 +chr6 108573604 108573692 5S 562 + 108573604 108573692 0 1 88 0 +chr6 110010047 110010091 5S 225 - 110010047 110010091 0 1 44 0 +chr6 110074368 110074458 5S 800 - 110074368 110074458 0 1 90 0 +chr6 114472446 114472714 LSU-rRNA_Hsa 649 + 114472446 114472714 0 1 268 0 +chr6 114541860 114541949 5S 591 - 114541860 114541949 0 1 89 0 +chr6 115273212 115273263 5S 364 - 115273212 115273263 0 1 51 0 +chr6 116499409 116499496 5S 651 - 116499409 116499496 0 1 87 0 +chr6 117381849 117381959 5S 782 + 117381849 117381959 0 1 110 0 +chr6 118349015 118349055 5S 292 - 118349015 118349055 0 1 40 0 +chr6 119039999 119040034 5S 269 + 119039999 119040034 0 1 35 0 +chr6 120583441 120583547 LSU-rRNA_Hsa 752 + 120583441 120583547 0 1 106 0 +chr6 121007766 121007858 5S 695 + 121007766 121007858 0 1 92 0 +chr6 126301021 126301080 5S 462 - 126301021 126301080 0 1 59 0 +chr6 126386951 126386993 5S 261 - 126386951 126386993 0 1 42 0 +chr6 127639029 127639118 5S 536 - 127639029 127639118 0 1 89 0 +chr6 129019783 129019870 5S 493 + 129019783 129019870 0 1 87 0 +chr6 129814541 129814634 5S 652 - 129814541 129814634 0 1 93 0 +chr6 132401297 132401347 5S 355 - 132401297 132401347 0 1 50 0 +chr6 133593944 133594166 LSU-rRNA_Hsa 1633 + 133593944 133594166 0 1 222 0 +chr6 134578172 134578282 5S 808 + 134578172 134578282 0 1 110 0 +chr6 134995780 134996047 LSU-rRNA_Hsa 1598 + 134995780 134996047 0 1 267 0 +chr6 135596959 135597001 5S 306 - 135596959 135597001 0 1 42 0 +chr6 136951377 136951466 5S 624 + 136951377 136951466 0 1 89 0 +chr6 137059142 137059226 SSU-rRNA_Hsa 336 - 137059142 137059226 0 1 84 0 +chr6 137358722 137358834 LSU-rRNA_Hsa 317 + 137358722 137358834 0 1 112 0 +chr6 137627145 137627187 5S 301 + 137627145 137627187 0 1 42 0 +chr6 138698052 138698094 5S 293 + 138698052 138698094 0 1 42 0 +chr6 140479751 140479831 5S 471 - 140479751 140479831 0 1 80 0 +chr6 143770945 143771024 5S 492 + 143770945 143771024 0 1 79 0 +chr6 144692027 144692175 LSU-rRNA_Hsa 1139 - 144692027 144692175 0 1 148 0 +chr6 144692196 144692284 LSU-rRNA_Hsa 680 - 144692196 144692284 0 1 88 0 +chr6 146661561 146661645 5S 638 + 146661561 146661645 0 1 84 0 +chr6 150665153 150665281 SSU-rRNA_Hsa 743 + 150665153 150665281 0 1 128 0 +chr6 152157980 152158256 SSU-rRNA_Hsa 542 - 152157980 152158256 0 1 276 0 +chr6 152611080 152611168 5S 646 - 152611080 152611168 0 1 88 0 +chr6 152731409 152731531 5S 644 + 152731409 152731531 0 1 122 0 +chr6 153056934 153056972 5S 249 - 153056934 153056972 0 1 38 0 +chr6 153480390 153480480 5S 606 - 153480390 153480480 0 1 90 0 +chr6 153741575 153741661 5S 683 + 153741575 153741661 0 1 86 0 +chr6 161207528 161207613 5S 650 - 161207528 161207613 0 1 85 0 +chr6 162291117 162291207 5S 702 - 162291117 162291207 0 1 90 0 +chr6 162473065 162473108 5S 327 - 162473065 162473108 0 1 43 0 +chr6 163906224 163906265 5S 230 - 163906224 163906265 0 1 41 0 +chr6 165823050 165823140 5S 800 + 165823050 165823140 0 1 90 0 +chr6 170709405 170709518 5S 258 + 170709405 170709518 0 1 113 0 +chr7 3025176 3025266 LSU-rRNA_Hsa 239 - 3025176 3025266 0 1 90 0 +chr7 5170828 5170870 5S 276 - 5170828 5170870 0 1 42 0 +chr7 5874406 5874448 5S 262 + 5874406 5874448 0 1 42 0 +chr7 11994347 11994389 5S 301 + 11994347 11994389 0 1 42 0 +chr7 14615740 14615782 5S 266 - 14615740 14615782 0 1 42 0 +chr7 22338212 22338302 5S 537 + 22338212 22338302 0 1 90 0 +chr7 23037678 23037720 5S 310 - 23037678 23037720 0 1 42 0 +chr7 24172327 24172413 5S 536 + 24172327 24172413 0 1 86 0 +chr7 25649911 25649953 5S 262 + 25649911 25649953 0 1 42 0 +chr7 26093482 26093524 5S 279 + 26093482 26093524 0 1 42 0 +chr7 27553378 27553502 LSU-rRNA_Hsa 274 - 27553378 27553502 0 1 124 0 +chr7 33123223 33123327 LSU-rRNA_Hsa 531 + 33123223 33123327 0 1 104 0 +chr7 33217351 33217443 5S 681 + 33217351 33217443 0 1 92 0 +chr7 36450441 36450483 5S 331 - 36450441 36450483 0 1 42 0 +chr7 36606004 36606101 LSU-rRNA_Hsa 323 + 36606004 36606101 0 1 97 0 +chr7 36633289 36633375 5S 590 - 36633289 36633375 0 1 86 0 +chr7 40301844 40301891 5S 241 + 40301844 40301891 0 1 47 0 +chr7 44165392 44165471 5S 461 - 44165392 44165471 0 1 79 0 +chr7 46120150 46120190 5S 292 + 46120150 46120190 0 1 40 0 +chr7 55110795 55110834 5S 298 - 55110795 55110834 0 1 39 0 +chr7 66015591 66015681 5S 627 - 66015591 66015681 0 1 90 0 +chr7 66681434 66681479 5S 287 - 66681434 66681479 0 1 45 0 +chr7 67786741 67786790 LSU-rRNA_Hsa 234 - 67786741 67786790 0 1 49 0 +chr7 68188948 68189038 5S 558 - 68188948 68189038 0 1 90 0 +chr7 68527370 68527788 LSU-rRNA_Hsa 3340 + 68527370 68527788 0 1 418 0 +chr7 71378726 71378840 5S 702 - 71378726 71378840 0 1 114 0 +chr7 72062543 72062588 5S 264 + 72062543 72062588 0 1 45 0 +chr7 73901755 73901870 5S 664 - 73901755 73901870 0 1 115 0 +chr7 74011128 74011218 5S 660 - 74011128 74011218 0 1 90 0 +chr7 74077260 74077313 LSU-rRNA_Hsa 356 - 74077260 74077313 0 1 53 0 +chr7 78431778 78431885 LSU-rRNA_Hsa 373 - 78431778 78431885 0 1 107 0 +chr7 79283426 79283514 5S 582 + 79283426 79283514 0 1 88 0 +chr7 80905339 80905409 LSU-rRNA_Hsa 451 + 80905339 80905409 0 1 70 0 +chr7 80962907 80963147 SSU-rRNA_Hsa 1812 + 80962907 80963147 0 1 240 0 +chr7 82647214 82647328 5S 576 + 82647214 82647328 0 1 114 0 +chr7 88597214 88597324 5S 525 + 88597214 88597324 0 1 110 0 +chr7 89406199 89406239 5S 253 + 89406199 89406239 0 1 40 0 +chr7 92043497 92043539 5S 252 + 92043497 92043539 0 1 42 0 +chr7 92436067 92436103 LSU-rRNA_Hsa 260 - 92436067 92436103 0 1 36 0 +chr7 94872503 94872587 LSU-rRNA_Hsa 353 + 94872503 94872587 0 1 84 0 +chr7 96340729 96340782 5S 284 - 96340729 96340782 0 1 53 0 +chr7 98863455 98863497 5S 291 - 98863455 98863497 0 1 42 0 +chr7 99065859 99066207 LSU-rRNA_Hsa 754 - 99065859 99066207 0 1 348 0 +chr7 99212191 99212234 5S 297 - 99212191 99212234 0 1 43 0 +chr7 101965496 101965608 LSU-rRNA_Hsa 597 - 101965496 101965608 0 1 112 0 +chr7 104536768 104536858 5S 561 + 104536768 104536858 0 1 90 0 +chr7 104630544 104630760 LSU-rRNA_Hsa 1025 + 104630544 104630760 0 1 216 0 +chr7 104641782 104641866 LSU-rRNA_Hsa 526 - 104641782 104641866 0 1 84 0 +chr7 104966297 104966532 LSU-rRNA_Hsa 997 + 104966297 104966532 0 1 235 0 +chr7 106422061 106422154 5S 460 - 106422061 106422154 0 1 93 0 +chr7 106526117 106526169 5S 303 - 106526117 106526169 0 1 52 0 +chr7 107927136 107927177 5S 260 - 107927136 107927177 0 1 41 0 +chr7 111593735 111593820 5S 479 - 111593735 111593820 0 1 85 0 +chr7 114253839 114253960 5S 723 - 114253839 114253960 0 1 121 0 +chr7 116584378 116584468 5S 638 - 116584378 116584468 0 1 90 0 +chr7 120537279 120537354 5S 410 - 120537279 120537354 0 1 75 0 +chr7 120621508 120621607 5S 517 - 120621508 120621607 0 1 99 0 +chr7 120723781 120723871 5S 594 - 120723781 120723871 0 1 90 0 +chr7 122403872 122403922 5S 356 - 122403872 122403922 0 1 50 0 +chr7 125923151 125923193 5S 257 + 125923151 125923193 0 1 42 0 +chr7 126159707 126159749 5S 326 + 126159707 126159749 0 1 42 0 +chr7 128074993 128075034 5S 292 + 128074993 128075034 0 1 41 0 +chr7 128118087 128118179 LSU-rRNA_Hsa 440 - 128118087 128118179 0 1 92 0 +chr7 128337505 128337612 5S 892 + 128337505 128337612 0 1 107 0 +chr7 128337744 128337798 5S 439 + 128337744 128337798 0 1 54 0 +chr7 129396105 129396193 5S 448 + 129396105 129396193 0 1 88 0 +chr7 129667116 129667204 5S 685 + 129667116 129667204 0 1 88 0 +chr7 130287669 130287790 5S 829 - 130287669 130287790 0 1 121 0 +chr7 131924563 131924605 5S 261 - 131924563 131924605 0 1 42 0 +chr7 133672674 133672756 5S 240 + 133672674 133672756 0 1 82 0 +chr7 135862193 135862300 LSU-rRNA_Hsa 316 - 135862193 135862300 0 1 107 0 +chr7 140070238 140070327 5S 612 + 140070238 140070327 0 1 89 0 +chr7 140086578 140086690 5S 687 - 140086578 140086690 0 1 112 0 +chr7 140486726 140486777 5S 386 + 140486726 140486777 0 1 51 0 +chr7 141107342 141107384 5S 347 + 141107342 141107384 0 1 42 0 +chr7 143151113 143151226 LSU-rRNA_Hsa 599 + 143151113 143151226 0 1 113 0 +chr7 147546975 147547054 5S 425 + 147546975 147547054 0 1 79 0 +chr7 148481396 148481485 5S 564 - 148481396 148481485 0 1 89 0 +chr7 149811828 149811867 5S 246 + 149811828 149811867 0 1 39 0 +chr7 152290059 152290175 5S 883 - 152290059 152290175 0 1 116 0 +chr7 153683125 153683164 5S 263 - 153683125 153683164 0 1 39 0 +chr7 158026214 158026258 5S 228 - 158026214 158026258 0 1 44 0 +chr8 3558013 3558093 5S 510 + 3558013 3558093 0 1 80 0 +chr8 4038756 4038797 5S 282 + 4038756 4038797 0 1 41 0 +chr8 4969321 4969359 5S 293 + 4969321 4969359 0 1 38 0 +chr8 7249943 7250033 5S 576 + 7249943 7250033 0 1 90 0 +chr8 7776915 7777005 5S 576 - 7776915 7777005 0 1 90 0 +chr8 8688928 8688997 5S 414 + 8688928 8688997 0 1 69 0 +chr8 9734204 9734274 5S 463 - 9734204 9734274 0 1 70 0 +chr8 10544078 10544191 5S 706 + 10544078 10544191 0 1 113 0 +chr8 11944917 11944968 5S 299 - 11944917 11944968 0 1 51 0 +chr8 12191165 12191216 5S 301 - 12191165 12191216 0 1 51 0 +chr8 13393537 13393617 5S 563 + 13393537 13393617 0 1 80 0 +chr8 13579498 13579544 5S 291 + 13579498 13579544 0 1 46 0 +chr8 17574664 17574842 SSU-rRNA_Hsa 246 - 17574664 17574842 0 1 178 0 +chr8 17605626 17605717 5S 669 + 17605626 17605717 0 1 91 0 +chr8 19712054 19712530 LSU-rRNA_Hsa 1293 + 19712054 19712530 0 1 476 0 +chr8 19934640 19934742 LSU-rRNA_Hsa 312 + 19934640 19934742 0 1 102 0 +chr8 20147684 20147774 5S 594 + 20147684 20147774 0 1 90 0 +chr8 21455971 21456306 LSU-rRNA_Hsa 2234 + 21455971 21456306 0 1 335 0 +chr8 25994396 25994515 5S 784 + 25994396 25994515 0 1 119 0 +chr8 28387927 28388016 5S 648 + 28387927 28388016 0 1 89 0 +chr8 28906031 28906120 5S 699 - 28906031 28906120 0 1 89 0 +chr8 29360846 29360883 LSU-rRNA_Hsa 236 + 29360846 29360883 0 1 37 0 +chr8 31455630 31455720 5S 556 - 31455630 31455720 0 1 90 0 +chr8 32011092 32011135 5S 246 + 32011092 32011135 0 1 43 0 +chr8 32049593 32049664 5S 470 - 32049593 32049664 0 1 71 0 +chr8 32114011 32114124 5S 733 + 32114011 32114124 0 1 113 0 +chr8 32870877 32871051 LSU-rRNA_Hsa 234 + 32870877 32871051 0 1 174 0 +chr8 36621962 36622036 5S 460 + 36621962 36622036 0 1 74 0 +chr8 39113654 39113694 5S 288 + 39113654 39113694 0 1 40 0 +chr8 42979609 42979659 5S 279 - 42979609 42979659 0 1 50 0 +chr8 46951570 46952097 LSU-rRNA_Hsa 2649 - 46951570 46952097 0 1 527 0 +chr8 46952095 46952182 LSU-rRNA_Hsa 505 - 46952095 46952182 0 1 87 0 +chr8 49375956 49376033 LSU-rRNA_Hsa 651 - 49375956 49376033 0 1 77 0 +chr8 50080450 50080498 5S 266 - 50080450 50080498 0 1 48 0 +chr8 52458865 52458953 5S 635 + 52458865 52458953 0 1 88 0 +chr8 53003215 53003257 5S 274 - 53003215 53003257 0 1 42 0 +chr8 55887281 55887323 SSU-rRNA_Hsa 225 + 55887281 55887323 0 1 42 0 +chr8 56657788 56657876 5S 607 + 56657788 56657876 0 1 88 0 +chr8 56755032 56755341 LSU-rRNA_Hsa 2153 - 56755032 56755341 0 1 309 0 +chr8 56821653 56822036 LSU-rRNA_Hsa 1553 - 56821653 56822036 0 1 383 0 +chr8 57201887 57201928 5S 295 - 57201887 57201928 0 1 41 0 +chr8 58039231 58039318 5S 564 - 58039231 58039318 0 1 87 0 +chr8 60368443 60368533 5S 718 + 60368443 60368533 0 1 90 0 +chr8 61156161 61156203 5S 345 + 61156161 61156203 0 1 42 0 +chr8 63051550 63051602 5S 332 - 63051550 63051602 0 1 52 0 +chr8 63367483 63367699 LSU-rRNA_Hsa 362 + 63367483 63367699 0 1 216 0 +chr8 66510359 66510401 5S 313 - 66510359 66510401 0 1 42 0 +chr8 68011537 68011627 5S 515 + 68011537 68011627 0 1 90 0 +chr8 69218440 69218796 LSU-rRNA_Hsa 2039 - 69218440 69218796 0 1 356 0 +chr8 69218794 69218922 LSU-rRNA_Hsa 870 + 69218794 69218922 0 1 128 0 +chr8 69607891 69607967 5S 524 + 69607891 69607967 0 1 76 0 +chr8 70602248 70602620 LSU-rRNA_Hsa 2903 - 70602248 70602620 0 1 372 0 +chr8 70842139 70842259 5S 626 + 70842139 70842259 0 1 120 0 +chr8 71828709 71828755 5S 274 + 71828709 71828755 0 1 46 0 +chr8 71986419 71986460 5S 236 - 71986419 71986460 0 1 41 0 +chr8 73269967 73270040 5S 499 + 73269967 73270040 0 1 73 0 +chr8 76906125 76906176 5S 267 - 76906125 76906176 0 1 51 0 +chr8 77280360 77280468 LSU-rRNA_Hsa 326 - 77280360 77280468 0 1 108 0 +chr8 77819698 77819752 5S 307 + 77819698 77819752 0 1 54 0 +chr8 84673782 84673824 5S 241 + 84673782 84673824 0 1 42 0 +chr8 87128872 87128918 5S 352 - 87128872 87128918 0 1 46 0 +chr8 89408690 89408776 5S 544 - 89408690 89408776 0 1 86 0 +chr8 91523363 91523469 5S 752 + 91523363 91523469 0 1 106 0 +chr8 93179688 93179778 5S 799 - 93179688 93179778 0 1 90 0 +chr8 94453504 94453594 5S 610 + 94453504 94453594 0 1 90 0 +chr8 94709613 94709688 5S 367 + 94709613 94709688 0 1 75 0 +chr8 97178596 97178687 5S 265 + 97178596 97178687 0 1 91 0 +chr8 97857963 97858005 5S 264 - 97857963 97858005 0 1 42 0 +chr8 98577733 98577938 LSU-rRNA_Hsa 1284 + 98577733 98577938 0 1 205 0 +chr8 100986335 100986394 5S 344 + 100986335 100986394 0 1 59 0 +chr8 102550179 102550322 LSU-rRNA_Hsa 916 - 102550179 102550322 0 1 143 0 +chr8 103491489 103491536 LSU-rRNA_Hsa 240 - 103491489 103491536 0 1 47 0 +chr8 103533411 103533462 5S 376 - 103533411 103533462 0 1 51 0 +chr8 106206880 106206921 5S 246 - 106206880 106206921 0 1 41 0 +chr8 108896721 108896840 5S 705 + 108896721 108896840 0 1 119 0 +chr8 109304591 109304662 LSU-rRNA_Hsa 566 - 109304591 109304662 0 1 71 0 +chr8 109536847 109536927 5S 409 - 109536847 109536927 0 1 80 0 +chr8 111990680 111990720 5S 238 - 111990680 111990720 0 1 40 0 +chr8 113346339 113346379 5S 247 - 113346339 113346379 0 1 40 0 +chr8 114025683 114025727 5S 250 - 114025683 114025727 0 1 44 0 +chr8 117034927 117035014 5S 697 - 117034927 117035014 0 1 87 0 +chr8 117952298 117952336 5S 285 - 117952298 117952336 0 1 38 0 +chr8 120903399 120903469 5S 519 - 120903399 120903469 0 1 70 0 +chr8 121386127 121386169 5S 282 - 121386127 121386169 0 1 42 0 +chr8 122187143 122187185 5S 258 - 122187143 122187185 0 1 42 0 +chr8 123958073 123958115 5S 311 + 123958073 123958115 0 1 42 0 +chr8 124232699 124232750 5S 370 + 124232699 124232750 0 1 51 0 +chr8 133766519 133766561 5S 301 + 133766519 133766561 0 1 42 0 +chr8 138472198 138472274 5S 245 + 138472198 138472274 0 1 76 0 +chr8 139815622 139815693 5S 528 - 139815622 139815693 0 1 71 0 +chr8 140690398 140690510 LSU-rRNA_Hsa 257 - 140690398 140690510 0 1 112 0 +chr8 141950660 141950763 5S 517 + 141950660 141950763 0 1 103 0 +chr9 401793 401835 5S 264 + 401793 401835 0 1 42 0 +chr9 1212195 1212358 SSU-rRNA_Hsa 696 - 1212195 1212358 0 1 163 0 +chr9 1333833 1333923 5S 651 + 1333833 1333923 0 1 90 0 +chr9 4691651 4691745 LSU-rRNA_Hsa 249 - 4691651 4691745 0 1 94 0 +chr9 4799734 4800000 SSU-rRNA_Hsa 1865 - 4799734 4800000 0 1 266 0 +chr9 7071820 7071862 5S 302 + 7071820 7071862 0 1 42 0 +chr9 7622268 7622335 LSU-rRNA_Hsa 252 + 7622268 7622335 0 1 67 0 +chr9 8740132 8740176 5S 284 + 8740132 8740176 0 1 44 0 +chr9 15220863 15220962 5S 639 + 15220863 15220962 0 1 99 0 +chr9 17001117 17001241 LSU-rRNA_Hsa 723 - 17001117 17001241 0 1 124 0 +chr9 19278552 19278593 LSU-rRNA_Hsa 331 + 19278552 19278593 0 1 41 0 +chr9 19492825 19492988 LSU-rRNA_Hsa 781 - 19492825 19492988 0 1 163 0 +chr9 20846586 20846762 LSU-rRNA_Hsa 360 + 20846586 20846762 0 1 176 0 +chr9 22108404 22108440 5S 277 - 22108404 22108440 0 1 36 0 +chr9 26081081 26081194 LSU-rRNA_Hsa 226 - 26081081 26081194 0 1 113 0 +chr9 27198284 27198354 5S 430 + 27198284 27198354 0 1 70 0 +chr9 28260562 28260626 LSU-rRNA_Hsa 269 + 28260562 28260626 0 1 64 0 +chr9 29042223 29042265 5S 297 + 29042223 29042265 0 1 42 0 +chr9 32537938 32538167 SSU-rRNA_Hsa 573 + 32537938 32538167 0 1 229 0 +chr9 33219984 33220031 LSU-rRNA_Hsa 336 - 33219984 33220031 0 1 47 0 +chr9 33658622 33658771 LSU-rRNA_Hsa 234 + 33658622 33658771 0 1 149 0 +chr9 34206154 34206239 5S 583 - 34206154 34206239 0 1 85 0 +chr9 37421880 37421963 5S 423 - 37421880 37421963 0 1 83 0 +chr9 66458141 66458262 5S 683 - 66458141 66458262 0 1 121 0 +chr9 68408923 68409043 5S 654 + 68408923 68409043 0 1 120 0 +chr9 71835184 71835226 5S 315 - 71835184 71835226 0 1 42 0 +chr9 74914668 74914749 5S 598 - 74914668 74914749 0 1 81 0 +chr9 76045221 76045262 5S 322 - 76045221 76045262 0 1 41 0 +chr9 76365846 76365886 5S 273 - 76365846 76365886 0 1 40 0 +chr9 76365886 76365974 5S 640 - 76365886 76365974 0 1 88 0 +chr9 79186648 79186950 LSU-rRNA_Hsa 1762 + 79186648 79186950 0 1 302 0 +chr9 81503776 81503826 5S 361 - 81503776 81503826 0 1 50 0 +chr9 84036635 84036721 SSU-rRNA_Hsa 567 + 84036635 84036721 0 1 86 0 +chr9 84500411 84500490 5S 431 + 84500411 84500490 0 1 79 0 +chr9 85698145 85698184 5S 237 + 85698145 85698184 0 1 39 0 +chr9 86618416 86618455 5S 251 + 86618416 86618455 0 1 39 0 +chr9 88082355 88082405 5S 323 - 88082355 88082405 0 1 50 0 +chr9 90606456 90606497 5S 308 + 90606456 90606497 0 1 41 0 +chr9 96363081 96363173 5S 475 - 96363081 96363173 0 1 92 0 +chr9 97904728 97904823 5S 458 - 97904728 97904823 0 1 95 0 +chr9 98667286 98667375 5S 647 + 98667286 98667375 0 1 89 0 +chr9 101908158 101908247 5S 706 - 101908158 101908247 0 1 89 0 +chr9 106052412 106052732 LSU-rRNA_Hsa 1017 + 106052412 106052732 0 1 320 0 +chr9 106451769 106451855 5S 474 - 106451769 106451855 0 1 86 0 +chr9 107045875 107045950 LSU-rRNA_Hsa 259 + 107045875 107045950 0 1 75 0 +chr9 107639714 107639767 5S 263 - 107639714 107639767 0 1 53 0 +chr9 109606057 109606147 5S 583 - 109606057 109606147 0 1 90 0 +chr9 109963063 109963142 5S 526 + 109963063 109963142 0 1 79 0 +chr9 111398597 111398678 5S 558 + 111398597 111398678 0 1 81 0 +chr9 112778497 112778539 5S 290 + 112778497 112778539 0 1 42 0 +chr9 113823993 113824152 LSU-rRNA_Hsa 335 + 113823993 113824152 0 1 159 0 +chr9 114173933 114174022 5S 504 - 114173933 114174022 0 1 89 0 +chr9 115014537 115014627 5S 745 + 115014537 115014627 0 1 90 0 +chr9 123867410 123867491 5S 366 + 123867410 123867491 0 1 81 0 +chr9 124252616 124252658 5S 304 + 124252616 124252658 0 1 42 0 +chr9 126813737 126813813 LSU-rRNA_Hsa 621 - 126813737 126813813 0 1 76 0 +chr9 130603428 130603496 5S 404 - 130603428 130603496 0 1 68 0 +chr9 131431165 131431227 LSU-rRNA_Hsa 309 + 131431165 131431227 0 1 62 0 +chr9 134064625 134064664 5S 265 - 134064625 134064664 0 1 39 0 +chr9 136940173 136940235 5S 227 + 136940173 136940235 0 1 62 0 +chr9 138362322 138362381 LSU-rRNA_Hsa 308 - 138362322 138362381 0 1 59 0 +chr9 140687334 140687522 LSU-rRNA_Hsa 1107 + 140687334 140687522 0 1 188 0 +chrM 2591 2747 LSU-rRNA_Hsa 324 + 2591 2747 0 1 156 0 +chrX 1419146 1419257 5S 525 - 1419146 1419257 0 1 111 0 +chrX 9101869 9101989 5S 865 + 9101869 9101989 0 1 120 0 +chrX 9371976 9372053 5S 338 + 9371976 9372053 0 1 77 0 +chrX 9372223 9372328 5S 302 + 9372223 9372328 0 1 105 0 +chrX 9373154 9373204 5S 321 + 9373154 9373204 0 1 50 0 +chrX 9374198 9374278 5S 333 + 9374198 9374278 0 1 80 0 +chrX 9375130 9375180 5S 288 + 9375130 9375180 0 1 50 0 +chrX 9376060 9376176 5S 315 + 9376060 9376176 0 1 116 0 +chrX 9376992 9377108 5S 305 + 9376992 9377108 0 1 116 0 +chrX 9377923 9378029 5S 329 + 9377923 9378029 0 1 106 0 +chrX 9378967 9379047 5S 333 + 9378967 9379047 0 1 80 0 +chrX 9379899 9380015 5S 328 + 9379899 9380015 0 1 116 0 +chrX 9380945 9381024 5S 260 + 9380945 9381024 0 1 79 0 +chrX 9381989 9382069 5S 333 + 9381989 9382069 0 1 80 0 +chrX 13259723 13259760 5S 263 - 13259723 13259760 0 1 37 0 +chrX 13591996 13592054 LSU-rRNA_Hsa 277 + 13591996 13592054 0 1 58 0 +chrX 13593757 13593957 LSU-rRNA_Hsa 610 + 13593757 13593957 0 1 200 0 +chrX 16352365 16352409 SSU-rRNA_Hsa 254 + 16352365 16352409 0 1 44 0 +chrX 16352806 16352903 SSU-rRNA_Hsa 254 + 16352806 16352903 0 1 97 0 +chrX 17648357 17648399 5S 278 + 17648357 17648399 0 1 42 0 +chrX 17841805 17841847 5S 270 + 17841805 17841847 0 1 42 0 +chrX 23465833 23465884 5S 405 + 23465833 23465884 0 1 51 0 +chrX 27726519 27726605 5S 451 + 27726519 27726605 0 1 86 0 +chrX 28988853 28988926 5S 529 + 28988853 28988926 0 1 73 0 +chrX 29000966 29001087 5S 886 - 29000966 29001087 0 1 121 0 +chrX 30909185 30909341 LSU-rRNA_Hsa 435 + 30909185 30909341 0 1 156 0 +chrX 32120181 32120271 5S 596 + 32120181 32120271 0 1 90 0 +chrX 32611588 32611734 SSU-rRNA_Hsa 624 + 32611588 32611734 0 1 146 0 +chrX 34234074 34234164 SSU-rRNA_Hsa 641 + 34234074 34234164 0 1 90 0 +chrX 35530130 35530254 LSU-rRNA_Hsa 257 - 35530130 35530254 0 1 124 0 +chrX 37912828 37912870 5S 293 + 37912828 37912870 0 1 42 0 +chrX 41152050 41152140 5S 706 + 41152050 41152140 0 1 90 0 +chrX 44564652 44564703 5S 358 - 44564652 44564703 0 1 51 0 +chrX 47175511 47175577 LSU-rRNA_Hsa 395 - 47175511 47175577 0 1 66 0 +chrX 47749438 47749802 LSU-rRNA_Hsa 1723 - 47749438 47749802 0 1 364 0 +chrX 48065692 48065783 5S 504 + 48065692 48065783 0 1 91 0 +chrX 48082886 48082929 5S 363 + 48082886 48082929 0 1 43 0 +chrX 48094787 48094887 5S 517 - 48094787 48094887 0 1 100 0 +chrX 48420548 48420630 5S 581 - 48420548 48420630 0 1 82 0 +chrX 48493261 48493303 5S 288 + 48493261 48493303 0 1 42 0 +chrX 50545675 50545733 5S 328 - 50545675 50545733 0 1 58 0 +chrX 52694280 52694371 5S 568 + 52694280 52694371 0 1 91 0 +chrX 53773054 53773103 5S 299 - 53773054 53773103 0 1 49 0 +chrX 53935487 53935597 5S 649 + 53935487 53935597 0 1 110 0 +chrX 54403620 54403690 LSU-rRNA_Hsa 406 + 54403620 54403690 0 1 70 0 +chrX 55288039 55288080 5S 268 - 55288039 55288080 0 1 41 0 +chrX 57789060 57789110 5S 347 - 57789060 57789110 0 1 50 0 +chrX 63360949 63360991 5S 287 + 63360949 63360991 0 1 42 0 +chrX 68892322 68892443 5S 1036 + 68892322 68892443 0 1 121 0 +chrX 69472892 69472980 5S 701 + 69472892 69472980 0 1 88 0 +chrX 70654814 70654855 5S 243 + 70654814 70654855 0 1 41 0 +chrX 73576006 73576044 5S 230 - 73576006 73576044 0 1 38 0 +chrX 75875438 75875528 5S 668 - 75875438 75875528 0 1 90 0 +chrX 76287129 76287250 5S 855 + 76287129 76287250 0 1 121 0 +chrX 77092696 77092734 5S 290 + 77092696 77092734 0 1 38 0 +chrX 80649907 80649949 5S 310 - 80649907 80649949 0 1 42 0 +chrX 84565079 84565156 5S 571 - 84565079 84565156 0 1 77 0 +chrX 88083253 88083341 LSU-rRNA_Hsa 355 + 88083253 88083341 0 1 88 0 +chrX 88735757 88735818 LSU-rRNA_Hsa 395 + 88735757 88735818 0 1 61 0 +chrX 88735818 88735906 LSU-rRNA_Hsa 718 + 88735818 88735906 0 1 88 0 +chrX 88735900 88735943 LSU-rRNA_Hsa 319 + 88735900 88735943 0 1 43 0 +chrX 94837062 94837152 5S 671 + 94837062 94837152 0 1 90 0 +chrX 96403595 96403673 5S 425 + 96403595 96403673 0 1 78 0 +chrX 96772866 96773065 LSU-rRNA_Hsa 766 + 96772866 96773065 0 1 199 0 +chrX 96773062 96773262 LSU-rRNA_Hsa 668 + 96773062 96773262 0 1 200 0 +chrX 98153086 98153123 5S 247 - 98153086 98153123 0 1 37 0 +chrX 101558218 101558257 5S 286 + 101558218 101558257 0 1 39 0 +chrX 101638739 101638778 5S 286 - 101638739 101638778 0 1 39 0 +chrX 102383346 102383381 5S 245 + 102383346 102383381 0 1 35 0 +chrX 103105751 103105841 5S 672 - 103105751 103105841 0 1 90 0 +chrX 105184139 105184180 5S 289 - 105184139 105184180 0 1 41 0 +chrX 106835549 106835588 5S 247 + 106835549 106835588 0 1 39 0 +chrX 106962550 106962592 5S 321 + 106962550 106962592 0 1 42 0 +chrX 108297348 108297830 LSU-rRNA_Hsa 4045 + 108297348 108297830 0 1 482 0 +chrX 110913055 110913176 5S 799 - 110913055 110913176 0 1 121 0 +chrX 113377507 113377557 5S 364 - 113377507 113377557 0 1 50 0 +chrX 115521101 115521246 LSU-rRNA_Hsa 238 + 115521101 115521246 0 1 145 0 +chrX 116134849 116134890 5S 266 - 116134849 116134890 0 1 41 0 +chrX 117333911 117334190 SSU-rRNA_Hsa 999 - 117333911 117334190 0 1 279 0 +chrX 122388041 122388084 5S 235 + 122388041 122388084 0 1 43 0 +chrX 123197331 123197374 5S 303 - 123197331 123197374 0 1 43 0 +chrX 123685042 123685081 5S 251 - 123685042 123685081 0 1 39 0 +chrX 128570507 128570624 5S 895 - 128570507 128570624 0 1 117 0 +chrX 128733731 128733773 5S 269 - 128733731 128733773 0 1 42 0 +chrX 128896278 128896320 5S 339 - 128896278 128896320 0 1 42 0 +chrX 131072894 131072983 5S 586 - 131072894 131072983 0 1 89 0 +chrX 133660310 133660450 LSU-rRNA_Hsa 840 - 133660310 133660450 0 1 140 0 +chrX 134108836 134108891 LSU-rRNA_Hsa 225 - 134108836 134108891 0 1 55 0 +chrX 134562090 134562209 5S 857 - 134562090 134562209 0 1 119 0 +chrX 139858392 139858607 LSU-rRNA_Hsa 1413 + 139858392 139858607 0 1 215 0 +chrX 141498838 141498959 5S 839 + 141498838 141498959 0 1 121 0 +chrX 145509000 145509090 5S 634 - 145509000 145509090 0 1 90 0 +chrX 147089618 147089734 5S 679 - 147089618 147089734 0 1 116 0 +chrX 150194788 150194876 5S 619 - 150194788 150194876 0 1 88 0 +chrY 1369146 1369257 5S 525 - 1369146 1369257 0 1 111 0 +chrY 3004989 3005050 LSU-rRNA_Hsa 396 + 3004989 3005050 0 1 61 0 +chrY 3005050 3005141 LSU-rRNA_Hsa 733 + 3005050 3005141 0 1 91 0 +chrY 3005132 3005175 LSU-rRNA_Hsa 283 + 3005132 3005175 0 1 43 0 +chrY 9928016 9928136 5S 806 - 9928016 9928136 0 1 120 0 +chrY 9930481 9930602 5S 681 - 9930481 9930602 0 1 121 0 +chrY 10034864 10036712 SSU-rRNA_Hsa 14100 + 10034864 10036712 0 1 1848 0 +chrY 19669743 19669858 5S 714 + 19669743 19669858 0 1 115 0 +chrY 19671653 19671771 5S 648 + 19671653 19671771 0 1 118 0 +chrY 19691913 19692439 LSU-rRNA_Hsa 2494 - 19691913 19692439 0 1 526 0 +chrY 19692437 19692524 LSU-rRNA_Hsa 436 - 19692437 19692524 0 1 87 0 +chrY 20487248 20487335 LSU-rRNA_Hsa 468 + 20487248 20487335 0 1 87 0 +chrY 20487333 20487859 LSU-rRNA_Hsa 2706 + 20487333 20487859 0 1 526 0 +chrY 20508006 20508124 5S 624 - 20508006 20508124 0 1 118 0 +chrY 20509918 20510033 5S 690 - 20509918 20510033 0 1 115 0 +chrY 22682756 22682804 5S 250 + 22682756 22682804 0 1 48 0 +chr10 200793 200880 5S 614 - 200793 200880 0 1 87 0 +chr10 327975 328065 5S 817 - 327975 328065 0 1 90 0 +chr10 4176714 4176756 5S 272 - 4176714 4176756 0 1 42 0 +chr10 5341746 5341873 LSU-rRNA_Hsa 799 - 5341746 5341873 0 1 127 0 +chr10 5942280 5942322 5S 313 - 5942280 5942322 0 1 42 0 +chr10 8698678 8698794 5S 631 - 8698678 8698794 0 1 116 0 +chr10 9206289 9206370 LSU-rRNA_Hsa 554 + 9206289 9206370 0 1 81 0 +chr10 10365946 10365987 5S 315 - 10365946 10365987 0 1 41 0 +chr10 10366002 10366043 5S 250 - 10366002 10366043 0 1 41 0 +chr10 12966697 12966784 5S 573 - 12966697 12966784 0 1 87 0 +chr10 13769795 13769885 5S 651 + 13769795 13769885 0 1 90 0 +chr10 14705403 14705493 5S 730 - 14705403 14705493 0 1 90 0 +chr10 18907897 18907948 5S 338 + 18907897 18907948 0 1 51 0 +chr10 19922610 19922732 5S 593 - 19922610 19922732 0 1 122 0 +chr10 21454525 21454564 5S 298 + 21454525 21454564 0 1 39 0 +chr10 23286209 23286280 5S 433 + 23286209 23286280 0 1 71 0 +chr10 24157019 24157067 5S 379 + 24157019 24157067 0 1 48 0 +chr10 24929094 24929215 5S 814 + 24929094 24929215 0 1 121 0 +chr10 26102737 26102846 5S 622 - 26102737 26102846 0 1 109 0 +chr10 26798522 26798615 5S 523 + 26798522 26798615 0 1 93 0 +chr10 29163320 29163419 5S 718 - 29163320 29163419 0 1 99 0 +chr10 31103813 31103855 5S 246 - 31103813 31103855 0 1 42 0 +chr10 31548527 31548617 5S 459 + 31548527 31548617 0 1 90 0 +chr10 31828324 31828373 5S 321 + 31828324 31828373 0 1 49 0 +chr10 32122000 32122053 LSU-rRNA_Hsa 353 - 32122000 32122053 0 1 53 0 +chr10 32699246 32699626 LSU-rRNA_Hsa 1701 - 32699246 32699626 0 1 380 0 +chr10 35370876 35370941 LSU-rRNA_Hsa 261 - 35370876 35370941 0 1 65 0 +chr10 38123895 38123948 LSU-rRNA_Hsa 420 + 38123895 38123948 0 1 53 0 +chr10 46351767 46351870 5S 252 + 46351767 46351870 0 1 103 0 +chr10 46742028 46742143 5S 270 + 46742028 46742143 0 1 115 0 +chr10 47222341 47222456 5S 245 + 47222341 47222456 0 1 115 0 +chr10 48206894 48207009 5S 245 - 48206894 48207009 0 1 115 0 +chr10 48931789 48931904 5S 270 + 48931789 48931904 0 1 115 0 +chr10 50911036 50911419 LSU-rRNA_Hsa 2563 - 50911036 50911419 0 1 383 0 +chr10 51255392 51255495 5S 254 + 51255392 51255495 0 1 103 0 +chr10 51739424 51739539 5S 270 - 51739424 51739539 0 1 115 0 +chr10 55217947 55218035 5S 462 + 55217947 55218035 0 1 88 0 +chr10 55643222 55643351 LSU-rRNA_Hsa 496 - 55643222 55643351 0 1 129 0 +chr10 55654117 55654162 5S 334 - 55654117 55654162 0 1 45 0 +chr10 55934991 55935033 5S 256 + 55934991 55935033 0 1 42 0 +chr10 57359616 57359764 LSU-rRNA_Hsa 242 + 57359616 57359764 0 1 148 0 +chr10 61447835 61448128 LSU-rRNA_Hsa 1380 - 61447835 61448128 0 1 293 0 +chr10 61679154 61679233 5S 327 + 61679154 61679233 0 1 79 0 +chr10 62277181 62277222 5S 264 + 62277181 62277222 0 1 41 0 +chr10 66572202 66572244 5S 229 - 66572202 66572244 0 1 42 0 +chr10 68805210 68805496 LSU-rRNA_Hsa 1631 - 68805210 68805496 0 1 286 0 +chr10 70221163 70221283 5S 828 + 70221163 70221283 0 1 120 0 +chr10 70770154 70770289 LSU-rRNA_Hsa 778 - 70770154 70770289 0 1 135 0 +chr10 75466254 75466373 5S 258 + 75466254 75466373 0 1 119 0 +chr10 75986832 75986898 LSU-rRNA_Hsa 414 + 75986832 75986898 0 1 66 0 +chr10 79346807 79346896 5S 597 + 79346807 79346896 0 1 89 0 +chr10 79729671 79729756 LSU-rRNA_Hsa 497 - 79729671 79729756 0 1 85 0 +chr10 87812204 87812325 5S 830 + 87812204 87812325 0 1 121 0 +chr10 91637246 91637275 LSU-rRNA_Hsa 225 + 91637246 91637275 0 1 29 0 +chr10 91973233 91973275 5S 286 + 91973233 91973275 0 1 42 0 +chr10 92445898 92445940 5S 303 - 92445898 92445940 0 1 42 0 +chr10 95062946 95063031 5S 589 + 95062946 95063031 0 1 85 0 +chr10 95270347 95270437 5S 688 - 95270347 95270437 0 1 90 0 +chr10 95952619 95952669 5S 314 + 95952619 95952669 0 1 50 0 +chr10 98379132 98379232 5S 613 + 98379132 98379232 0 1 100 0 +chr10 101198811 101198878 LSU-rRNA_Hsa 483 + 101198811 101198878 0 1 67 0 +chr10 106406524 106406609 LSU-rRNA_Hsa 365 + 106406524 106406609 0 1 85 0 +chr10 108729779 108729868 5S 696 + 108729779 108729868 0 1 89 0 +chr10 109105514 109105549 5S 252 + 109105514 109105549 0 1 35 0 +chr10 109221318 109221407 5S 618 + 109221318 109221407 0 1 89 0 +chr10 112520899 112520989 5S 626 + 112520899 112520989 0 1 90 0 +chr10 120050213 120050254 5S 327 - 120050213 120050254 0 1 41 0 +chr10 122289205 122289270 LSU-rRNA_Hsa 429 + 122289205 122289270 0 1 65 0 +chr10 123576308 123576350 5S 241 + 123576308 123576350 0 1 42 0 +chr10 124717099 124717141 5S 264 + 124717099 124717141 0 1 42 0 +chr10 127311180 127311235 5S 365 - 127311180 127311235 0 1 55 0 +chr10 127834061 127834151 5S 556 - 127834061 127834151 0 1 90 0 +chr10 128263382 128263451 5S 322 + 128263382 128263451 0 1 69 0 +chr11 6038225 6038342 5S 862 + 6038225 6038342 0 1 117 0 +chr11 8739123 8739166 5S 361 - 8739123 8739166 0 1 43 0 +chr11 9230778 9230821 5S 276 + 9230778 9230821 0 1 43 0 +chr11 10529667 10529842 LSU-rRNA_Hsa 262 - 10529667 10529842 0 1 175 0 +chr11 10924426 10924468 5S 333 - 10924426 10924468 0 1 42 0 +chr11 13285470 13285642 SSU-rRNA_Hsa 897 + 13285470 13285642 0 1 172 0 +chr11 13639650 13639737 5S 575 + 13639650 13639737 0 1 87 0 +chr11 13929047 13929136 5S 694 - 13929047 13929136 0 1 89 0 +chr11 14156531 14156626 5S 719 + 14156531 14156626 0 1 95 0 +chr11 18269933 18270050 5S 725 - 18269933 18270050 0 1 117 0 +chr11 18287942 18288059 5S 725 + 18287942 18288059 0 1 117 0 +chr11 18770707 18770826 LSU-rRNA_Hsa 613 - 18770707 18770826 0 1 119 0 +chr11 19423438 19423528 5S 798 - 19423438 19423528 0 1 90 0 +chr11 21022385 21022426 5S 276 - 21022385 21022426 0 1 41 0 +chr11 21022426 21022511 5S 670 - 21022426 21022511 0 1 85 0 +chr11 21318775 21318815 5S 228 - 21318775 21318815 0 1 40 0 +chr11 21405350 21405455 5S 545 - 21405350 21405455 0 1 105 0 +chr11 22502384 22502526 LSU-rRNA_Hsa 467 + 22502384 22502526 0 1 142 0 +chr11 22709896 22709986 5S 652 + 22709896 22709986 0 1 90 0 +chr11 27129278 27129356 5S 427 - 27129278 27129356 0 1 78 0 +chr11 27543183 27543272 5S 601 - 27543183 27543272 0 1 89 0 +chr11 29053258 29053297 5S 277 + 29053258 29053297 0 1 39 0 +chr11 31621435 31621485 5S 357 - 31621435 31621485 0 1 50 0 +chr11 32185731 32185772 5S 325 + 32185731 32185772 0 1 41 0 +chr11 33285921 33285981 5S 349 - 33285921 33285981 0 1 60 0 +chr11 38785182 38785223 5S 229 + 38785182 38785223 0 1 41 0 +chr11 40282768 40282799 LSU-rRNA_Hsa 231 + 40282768 40282799 0 1 31 0 +chr11 47825843 47825953 5S 529 - 47825843 47825953 0 1 110 0 +chr11 48499423 48499498 5S 356 + 48499423 48499498 0 1 75 0 +chr11 49447711 49447761 5S 319 - 49447711 49447761 0 1 50 0 +chr11 49957299 49957375 5S 297 - 49957299 49957375 0 1 76 0 +chr11 51470427 51470502 5S 324 - 51470427 51470502 0 1 75 0 +chr11 57217655 57217742 5S 564 + 57217655 57217742 0 1 87 0 +chr11 57587124 57587168 5S 341 - 57587124 57587168 0 1 44 0 +chr11 64273960 64274014 5S 304 - 64273960 64274014 0 1 54 0 +chr11 67999042 67999437 LSU-rRNA_Hsa 1284 - 67999042 67999437 0 1 395 0 +chr11 68571596 68571685 5S 607 + 68571596 68571685 0 1 89 0 +chr11 71556254 71556305 5S 298 - 71556254 71556305 0 1 51 0 +chr11 72913399 72913516 5S 254 + 72913399 72913516 0 1 117 0 +chr11 73503098 73503365 LSU-rRNA_Hsa 605 + 73503098 73503365 0 1 267 0 +chr11 73909809 73909899 5S 723 - 73909809 73909899 0 1 90 0 +chr11 75645976 75646064 5S 557 + 75645976 75646064 0 1 88 0 +chr11 75858509 75858684 LSU-rRNA_Hsa 462 + 75858509 75858684 0 1 175 0 +chr11 77597473 77597831 LSU-rRNA_Hsa 2871 + 77597473 77597831 0 1 358 0 +chr11 82815952 82816035 LSU-rRNA_Hsa 542 + 82815952 82816035 0 1 83 0 +chr11 84792605 84792796 SSU-rRNA_Hsa 1108 - 84792605 84792796 0 1 191 0 +chr11 84792780 84792846 SSU-rRNA_Hsa 335 - 84792780 84792846 0 1 66 0 +chr11 85195011 85195307 LSU-rRNA_Hsa 2173 + 85195011 85195307 0 1 296 0 +chr11 85746312 85746437 LSU-rRNA_Hsa 257 - 85746312 85746437 0 1 125 0 +chr11 85755321 85755619 LSU-rRNA_Hsa 531 - 85755321 85755619 0 1 298 0 +chr11 86246362 86246512 SSU-rRNA_Hsa 436 + 86246362 86246512 0 1 150 0 +chr11 86478534 86478575 5S 271 - 86478534 86478575 0 1 41 0 +chr11 87864737 87864814 5S 341 + 87864737 87864814 0 1 77 0 +chr11 89007516 89007566 5S 321 + 89007516 89007566 0 1 50 0 +chr11 94453232 94453365 LSU-rRNA_Hsa 301 + 94453232 94453365 0 1 133 0 +chr11 95257209 95257298 5S 614 - 95257209 95257298 0 1 89 0 +chr11 95573200 95573287 5S 618 - 95573200 95573287 0 1 87 0 +chr11 97528463 97528584 5S 773 + 97528463 97528584 0 1 121 0 +chr11 99219886 99219928 5S 272 + 99219886 99219928 0 1 42 0 +chr11 101928584 101928646 5S 393 + 101928584 101928646 0 1 62 0 +chr11 101928648 101928728 5S 437 + 101928648 101928728 0 1 80 0 +chr11 102270296 102270351 5S 282 + 102270296 102270351 0 1 55 0 +chr11 103279643 103279808 LSU-rRNA_Hsa 270 - 103279643 103279808 0 1 165 0 +chr11 104123310 104123377 5S 548 + 104123310 104123377 0 1 67 0 +chr11 105265687 105265729 5S 264 + 105265687 105265729 0 1 42 0 +chr11 106201703 106201745 5S 243 - 106201703 106201745 0 1 42 0 +chr11 108991602 108991713 5S 744 - 108991602 108991713 0 1 111 0 +chr11 110022143 110022185 5S 256 - 110022143 110022185 0 1 42 0 +chr11 110910843 110910932 5S 673 - 110910843 110910932 0 1 89 0 +chr11 111691907 111692111 LSU-rRNA_Hsa 1042 - 111691907 111692111 0 1 204 0 +chr11 111692115 111692362 LSU-rRNA_Hsa 1833 - 111692115 111692362 0 1 247 0 +chr11 111692656 111692748 LSU-rRNA_Hsa 1833 - 111692656 111692748 0 1 92 0 +chr11 111799127 111799202 5S 578 + 111799127 111799202 0 1 75 0 +chr11 113297896 113297939 5S 249 + 113297896 113297939 0 1 43 0 +chr11 124506354 124506444 5S 788 + 124506354 124506444 0 1 90 0 +chr11 125023196 125023237 5S 282 - 125023196 125023237 0 1 41 0 +chr11 128604168 128604249 5S 378 + 128604168 128604249 0 1 81 0 +chr11 129159798 129159883 5S 606 + 129159798 129159883 0 1 85 0 +chr11 129278797 129279018 LSU-rRNA_Hsa 303 + 129278797 129279018 0 1 221 0 +chr12 10104432 10104478 5S 240 + 10104432 10104478 0 1 46 0 +chr12 11714804 11714846 5S 269 + 11714804 11714846 0 1 42 0 +chr12 12490899 12490940 5S 320 - 12490899 12490940 0 1 41 0 +chr12 13199085 13199175 5S 815 + 13199085 13199175 0 1 90 0 +chr12 13440666 13440713 5S 387 - 13440666 13440713 0 1 47 0 +chr12 13593843 13593935 5S 691 - 13593843 13593935 0 1 92 0 +chr12 17219717 17219795 5S 424 - 17219717 17219795 0 1 78 0 +chr12 17220157 17220174 5S 424 - 17220157 17220174 0 1 17 0 +chr12 18511178 18511316 LSU-rRNA_Hsa 852 - 18511178 18511316 0 1 138 0 +chr12 18511327 18511391 LSU-rRNA_Hsa 315 - 18511327 18511391 0 1 64 0 +chr12 19926144 19926303 LSU-rRNA_Hsa 364 + 19926144 19926303 0 1 159 0 +chr12 20704357 20704522 SSU-rRNA_Hsa 1355 + 20704357 20704522 0 1 165 0 +chr12 26526583 26526666 5S 596 - 26526583 26526666 0 1 83 0 +chr12 27960715 27960754 5S 304 - 27960715 27960754 0 1 39 0 +chr12 28658326 28658416 5S 751 + 28658326 28658416 0 1 90 0 +chr12 30459367 30459458 5S 621 - 30459367 30459458 0 1 91 0 +chr12 30657032 30657073 5S 287 + 30657032 30657073 0 1 41 0 +chr12 30846809 30846883 5S 323 + 30846809 30846883 0 1 74 0 +chr12 30887692 30887752 SSU-rRNA_Hsa 311 - 30887692 30887752 0 1 60 0 +chr12 31587334 31587375 5S 291 - 31587334 31587375 0 1 41 0 +chr12 32664772 32664822 5S 307 + 32664772 32664822 0 1 50 0 +chr12 34356803 34356856 5S 338 + 34356803 34356856 0 1 53 0 +chr12 34358633 34358754 5S 845 + 34358633 34358754 0 1 121 0 +chr12 34372315 34372605 LSU-rRNA_Hsa 1525 - 34372315 34372605 0 1 290 0 +chr12 34372607 34372741 LSU-rRNA_Hsa 684 - 34372607 34372741 0 1 134 0 +chr12 34372739 34372825 LSU-rRNA_Hsa 423 - 34372739 34372825 0 1 86 0 +chr12 38531376 38531463 LSU-rRNA_Hsa 382 + 38531376 38531463 0 1 87 0 +chr12 38531457 38531930 LSU-rRNA_Hsa 1399 + 38531457 38531930 0 1 473 0 +chr12 38555265 38555384 5S 684 - 38555265 38555384 0 1 119 0 +chr12 38557202 38557317 5S 830 - 38557202 38557317 0 1 115 0 +chr12 40033140 40033207 5S 390 + 40033140 40033207 0 1 67 0 +chr12 42052481 42052567 5S 528 + 42052481 42052567 0 1 86 0 +chr12 44082970 44083025 5S 340 + 44082970 44083025 0 1 55 0 +chr12 45417401 45417451 5S 281 + 45417401 45417451 0 1 50 0 +chr12 45511554 45511672 5S 789 + 45511554 45511672 0 1 118 0 +chr12 46634764 46634806 5S 274 + 46634764 46634806 0 1 42 0 +chr12 48588240 48588308 LSU-rRNA_Hsa 278 + 48588240 48588308 0 1 68 0 +chr12 49071772 49071835 5S 422 + 49071772 49071835 0 1 63 0 +chr12 50637225 50637275 5S 357 + 50637225 50637275 0 1 50 0 +chr12 52579766 52579815 5S 252 + 52579766 52579815 0 1 49 0 +chr12 56590697 56590753 LSU-rRNA_Hsa 234 + 56590697 56590753 0 1 56 0 +chr12 57264352 57264465 LSU-rRNA_Hsa 595 + 57264352 57264465 0 1 113 0 +chr12 57264510 57264552 5S 261 + 57264510 57264552 0 1 42 0 +chr12 60878044 60878080 LSU-rRNA_Hsa 238 - 60878044 60878080 0 1 36 0 +chr12 62787810 62787851 5S 269 + 62787810 62787851 0 1 41 0 +chr12 67766646 67766781 LSU-rRNA_Hsa 594 - 67766646 67766781 0 1 135 0 +chr12 68471365 68471450 5S 250 + 68471365 68471450 0 1 85 0 +chr12 69322838 69322910 LSU-rRNA_Hsa 488 + 69322838 69322910 0 1 72 0 +chr12 70063035 70063099 LSU-rRNA_Hsa 314 - 70063035 70063099 0 1 64 0 +chr12 71936901 71936943 5S 244 - 71936901 71936943 0 1 42 0 +chr12 72129472 72129525 5S 341 - 72129472 72129525 0 1 53 0 +chr12 72228953 72228995 5S 322 - 72228953 72228995 0 1 42 0 +chr12 75347340 75347450 LSU-rRNA_Hsa 632 - 75347340 75347450 0 1 110 0 +chr12 75347475 75347612 LSU-rRNA_Hsa 623 - 75347475 75347612 0 1 137 0 +chr12 75891844 75892084 LSU-rRNA_Hsa 459 + 75891844 75892084 0 1 240 0 +chr12 80272092 80272195 5S 674 - 80272092 80272195 0 1 103 0 +chr12 83458421 83458479 5S 429 - 83458421 83458479 0 1 58 0 +chr12 85562696 85562760 LSU-rRNA_Hsa 453 - 85562696 85562760 0 1 64 0 +chr12 86580980 86581021 5S 228 + 86580980 86581021 0 1 41 0 +chr12 88445470 88445561 5S 453 + 88445470 88445561 0 1 91 0 +chr12 88782327 88782366 5S 236 - 88782327 88782366 0 1 39 0 +chr12 90120710 90120795 5S 617 + 90120710 90120795 0 1 85 0 +chr12 90682698 90682740 5S 272 - 90682698 90682740 0 1 42 0 +chr12 92300685 92300727 5S 296 + 92300685 92300727 0 1 42 0 +chr12 94448738 94448903 LSU-rRNA_Hsa 341 + 94448738 94448903 0 1 165 0 +chr12 94450200 94450285 LSU-rRNA_Hsa 263 + 94450200 94450285 0 1 85 0 +chr12 94724243 94724329 SSU-rRNA_Hsa 355 + 94724243 94724329 0 1 86 0 +chr12 97834005 97834053 5S 291 - 97834005 97834053 0 1 48 0 +chr12 99027724 99027766 5S 327 - 99027724 99027766 0 1 42 0 +chr12 99477593 99477682 5S 679 - 99477593 99477682 0 1 89 0 +chr12 100183536 100183578 5S 250 + 100183536 100183578 0 1 42 0 +chr12 101866117 101866224 5S 467 + 101866117 101866224 0 1 107 0 +chr12 101923907 101923949 5S 244 + 101923907 101923949 0 1 42 0 +chr12 102173591 102173682 5S 773 + 102173591 102173682 0 1 91 0 +chr12 102230595 102230686 5S 640 + 102230595 102230686 0 1 91 0 +chr12 102279095 102279224 LSU-rRNA_Hsa 825 - 102279095 102279224 0 1 129 0 +chr12 104319849 104319959 SSU-rRNA_Hsa 728 - 104319849 104319959 0 1 110 0 +chr12 104519013 104519103 5S 815 + 104519013 104519103 0 1 90 0 +chr12 106126438 106126480 5S 276 - 106126438 106126480 0 1 42 0 +chr12 107665096 107665171 5S 530 - 107665096 107665171 0 1 75 0 +chr12 107880322 107880412 5S 588 - 107880322 107880412 0 1 90 0 +chr12 109497790 109497878 5S 491 + 109497790 109497878 0 1 88 0 +chr12 110058039 110058136 5S 463 - 110058039 110058136 0 1 97 0 +chr12 111777330 111777415 5S 474 + 111777330 111777415 0 1 85 0 +chr12 112168129 112168185 5S 320 + 112168129 112168185 0 1 56 0 +chr12 113166368 113166433 LSU-rRNA_Hsa 273 - 113166368 113166433 0 1 65 0 +chr12 114642865 114642907 5S 240 - 114642865 114642907 0 1 42 0 +chr12 118573638 118573695 LSU-rRNA_Hsa 343 - 118573638 118573695 0 1 57 0 +chr12 119267485 119267575 5S 651 + 119267485 119267575 0 1 90 0 +chr12 123767462 123767580 5S 622 - 123767462 123767580 0 1 118 0 +chr12 127650452 127650987 LSU-rRNA_Hsa 2141 - 127650452 127650987 0 1 535 0 +chr12 131784205 131784296 5S 602 - 131784205 131784296 0 1 91 0 +chr12 132145607 132145698 5S 560 + 132145607 132145698 0 1 91 0 +chr12 132285858 132285971 5S 685 - 132285858 132285971 0 1 113 0 +chr12 133300529 133300642 5S 614 - 133300529 133300642 0 1 113 0 +chr12 133624126 133624211 5S 650 - 133624126 133624211 0 1 85 0 +chr13 32374761 32374799 5S 256 + 32374761 32374799 0 1 38 0 +chr13 19662623 19662715 5S 483 + 19662623 19662715 0 1 92 0 +chr13 21920154 21920196 5S 327 + 21920154 21920196 0 1 42 0 +chr13 21943949 21944036 5S 562 - 21943949 21944036 0 1 87 0 +chr13 22041028 22041069 5S 256 + 22041028 22041069 0 1 41 0 +chr13 28109701 28109743 5S 321 + 28109701 28109743 0 1 42 0 +chr13 28718749 28718788 5S 272 - 28718749 28718788 0 1 39 0 +chr13 35378111 35378160 SSU-rRNA_Hsa 257 - 35378111 35378160 0 1 49 0 +chr13 37372429 37372511 5S 639 - 37372429 37372511 0 1 82 0 +chr13 37438518 37438593 5S 378 - 37438518 37438593 0 1 75 0 +chr13 38429017 38429107 5S 634 - 38429017 38429107 0 1 90 0 +chr13 43409803 43409845 5S 270 + 43409803 43409845 0 1 42 0 +chr13 46125616 46125737 5S 746 - 46125616 46125737 0 1 121 0 +chr13 49339027 49339116 5S 658 + 49339027 49339116 0 1 89 0 +chr13 51387122 51387242 5S 694 - 51387122 51387242 0 1 120 0 +chr13 51601900 51601987 5S 556 - 51601900 51601987 0 1 87 0 +chr13 54365339 54365455 5S 231 - 54365339 54365455 0 1 116 0 +chr13 54596459 54596525 LSU-rRNA_Hsa 337 - 54596459 54596525 0 1 66 0 +chr13 58565483 58565573 5S 683 + 58565483 58565573 0 1 90 0 +chr13 61187741 61187831 5S 470 + 61187741 61187831 0 1 90 0 +chr13 63343041 63343119 5S 367 + 63343041 63343119 0 1 78 0 +chr13 68208612 68208701 LSU-rRNA_Hsa 363 + 68208612 68208701 0 1 89 0 +chr13 68965870 68965961 LSU-rRNA_Hsa 566 + 68965870 68965961 0 1 91 0 +chr13 70598213 70598262 5S 318 - 70598213 70598262 0 1 49 0 +chr13 72552231 72552346 5S 616 + 72552231 72552346 0 1 115 0 +chr13 76138098 76138188 5S 583 - 76138098 76138188 0 1 90 0 +chr13 79963676 79963765 5S 566 - 79963676 79963765 0 1 89 0 +chr13 80655091 80655133 5S 295 - 80655091 80655133 0 1 42 0 +chr13 85257702 85257813 LSU-rRNA_Hsa 618 + 85257702 85257813 0 1 111 0 +chr13 86468163 86468203 5S 237 - 86468163 86468203 0 1 40 0 +chr13 90787999 90788094 5S 553 - 90787999 90788094 0 1 95 0 +chr13 92957222 92957262 5S 293 - 92957222 92957262 0 1 40 0 +chr13 94622265 94622307 5S 263 + 94622265 94622307 0 1 42 0 +chr13 94677762 94677852 5S 605 - 94677762 94677852 0 1 90 0 +chr13 95286500 95286593 LSU-rRNA_Hsa 306 - 95286500 95286593 0 1 93 0 +chr13 95303650 95303765 5S 531 - 95303650 95303765 0 1 115 0 +chr13 96732491 96732581 5S 551 - 96732491 96732581 0 1 90 0 +chr13 98015265 98015355 5S 685 - 98015265 98015355 0 1 90 0 +chr13 98360062 98360104 5S 274 + 98360062 98360104 0 1 42 0 +chr13 102311110 102311221 LSU-rRNA_Hsa 613 + 102311110 102311221 0 1 111 0 +chr13 103060936 103060978 5S 283 + 103060936 103060978 0 1 42 0 +chr13 104850117 104850200 LSU-rRNA_Hsa 310 - 104850117 104850200 0 1 83 0 +chr13 105199268 105199312 5S 269 + 105199268 105199312 0 1 44 0 +chr13 105691585 105691628 5S 273 + 105691585 105691628 0 1 43 0 +chr13 106807749 106807839 5S 615 - 106807749 106807839 0 1 90 0 +chr13 108953589 108953677 5S 555 - 108953589 108953677 0 1 88 0 +chr13 113598641 113598869 SSU-rRNA_Hsa 408 - 113598641 113598869 0 1 228 0 +chr14 20558288 20558368 5S 515 + 20558288 20558368 0 1 80 0 +chr14 20614222 20614314 5S 545 - 20614222 20614314 0 1 92 0 +chr14 20883145 20883235 5S 696 + 20883145 20883235 0 1 90 0 +chr14 22069929 22070018 5S 715 - 22069929 22070018 0 1 89 0 +chr14 22198247 22198313 LSU-rRNA_Hsa 439 - 22198247 22198313 0 1 66 0 +chr14 23986957 23987095 LSU-rRNA_Hsa 779 - 23986957 23987095 0 1 138 0 +chr14 24627811 24627933 5S 786 + 24627811 24627933 0 1 122 0 +chr14 33550349 33550392 5S 318 - 33550349 33550392 0 1 43 0 +chr14 43722995 43723045 LSU-rRNA_Hsa 311 + 43722995 43723045 0 1 50 0 +chr14 45486421 45486547 LSU-rRNA_Hsa 265 + 45486421 45486547 0 1 126 0 +chr14 49480412 49480478 LSU-rRNA_Hsa 236 + 49480412 49480478 0 1 66 0 +chr14 49554430 49554472 5S 346 + 49554430 49554472 0 1 42 0 +chr14 50019350 50019437 5S 562 + 50019350 50019437 0 1 87 0 +chr14 52159469 52159560 5S 634 + 52159469 52159560 0 1 91 0 +chr14 55423374 55423429 LSU-rRNA_Hsa 357 + 55423374 55423429 0 1 55 0 +chr14 56679273 56679413 LSU-rRNA_Hsa 341 - 56679273 56679413 0 1 140 0 +chr14 61089036 61089149 LSU-rRNA_Hsa 275 - 61089036 61089149 0 1 113 0 +chr14 67726943 67727031 5S 701 + 67726943 67727031 0 1 88 0 +chr14 68123819 68123926 5S 619 - 68123819 68123926 0 1 107 0 +chr14 70534100 70534190 5S 505 - 70534100 70534190 0 1 90 0 +chr14 72684648 72684746 LSU-rRNA_Hsa 494 + 72684648 72684746 0 1 98 0 +chr14 73468167 73468209 5S 242 + 73468167 73468209 0 1 42 0 +chr14 75819587 75819627 5S 351 - 75819587 75819627 0 1 40 0 +chr14 76070515 76070605 5S 782 + 76070515 76070605 0 1 90 0 +chr14 76529559 76529601 5S 349 + 76529559 76529601 0 1 42 0 +chr14 77870247 77870336 5S 747 - 77870247 77870336 0 1 89 0 +chr14 78644175 78644264 5S 723 - 78644175 78644264 0 1 89 0 +chr14 81047582 81047601 5S 225 + 81047582 81047601 0 1 19 0 +chr14 88596629 88596850 LSU-rRNA_Hsa 520 + 88596629 88596850 0 1 221 0 +chr14 88596900 88597173 LSU-rRNA_Hsa 343 + 88596900 88597173 0 1 273 0 +chr14 89988577 89988621 5S 279 - 89988577 89988621 0 1 44 0 +chr14 90341370 90341573 SSU-rRNA_Hsa 1620 - 90341370 90341573 0 1 203 0 +chr14 90817381 90817444 5S 316 + 90817381 90817444 0 1 63 0 +chr14 91737033 91737074 SSU-rRNA_Hsa 231 + 91737033 91737074 0 1 41 0 +chr14 92270232 92270316 5S 678 - 92270232 92270316 0 1 84 0 +chr14 92630837 92630879 5S 302 - 92630837 92630879 0 1 42 0 +chr14 97294894 97294936 5S 301 + 97294894 97294936 0 1 42 0 +chr14 100048779 100048821 5S 235 + 100048779 100048821 0 1 42 0 +chr14 103783283 103783373 5S 656 - 103783283 103783373 0 1 90 0 +chr14 105590080 105590122 5S 333 - 105590080 105590122 0 1 42 0 +chr14 107092676 107092766 5S 825 + 107092676 107092766 0 1 90 0 +chr15 20466418 20466459 5S 288 + 20466418 20466459 0 1 41 0 +chr15 23842427 23842478 5S 244 - 23842427 23842478 0 1 51 0 +chr15 25983655 25983735 5S 523 + 25983655 25983735 0 1 80 0 +chr15 27525463 27525582 5S 784 - 27525463 27525582 0 1 119 0 +chr15 27997239 27997544 LSU-rRNA_Hsa 798 + 27997239 27997544 0 1 305 0 +chr15 34340075 34340119 LSU-rRNA_Hsa 256 - 34340075 34340119 0 1 44 0 +chr15 35760565 35760654 SSU-rRNA_Hsa 251 + 35760565 35760654 0 1 89 0 +chr15 40623772 40623849 5S 512 - 40623772 40623849 0 1 77 0 +chr15 42144138 42144227 5S 671 - 42144138 42144227 0 1 89 0 +chr15 45007979 45008022 5S 263 + 45007979 45008022 0 1 43 0 +chr15 45845716 45845802 5S 545 - 45845716 45845802 0 1 86 0 +chr15 46366807 46367317 LSU-rRNA_Hsa 419 - 46366807 46367317 0 1 510 0 +chr15 46367529 46367610 LSU-rRNA_Hsa 376 - 46367529 46367610 0 1 81 0 +chr15 46368204 46368338 LSU-rRNA_Hsa 466 - 46368204 46368338 0 1 134 0 +chr15 46368399 46368706 LSU-rRNA_Hsa 367 - 46368399 46368706 0 1 307 0 +chr15 50274639 50274759 5S 687 + 50274639 50274759 0 1 120 0 +chr15 50755577 50755655 5S 445 + 50755577 50755655 0 1 78 0 +chr15 55578305 55578394 5S 668 + 55578305 55578394 0 1 89 0 +chr15 55655753 55655843 5S 524 + 55655753 55655843 0 1 90 0 +chr15 55950320 55950362 5S 274 - 55950320 55950362 0 1 42 0 +chr15 56724895 56724968 5S 444 - 56724895 56724968 0 1 73 0 +chr15 57686863 57686942 5S 377 - 57686863 57686942 0 1 79 0 +chr15 59203644 59203752 SSU-rRNA_Hsa 702 + 59203644 59203752 0 1 108 0 +chr15 59616545 59616641 LSU-rRNA_Hsa 444 + 59616545 59616641 0 1 96 0 +chr15 59866300 59866421 5S 802 - 59866300 59866421 0 1 121 0 +chr15 61028968 61029057 5S 662 + 61028968 61029057 0 1 89 0 +chr15 61877545 61877585 5S 252 - 61877545 61877585 0 1 40 0 +chr15 62977553 62977594 5S 269 + 62977553 62977594 0 1 41 0 +chr15 63720696 63720735 5S 257 + 63720696 63720735 0 1 39 0 +chr15 64683112 64683154 SSU-rRNA_Hsa 283 - 64683112 64683154 0 1 42 0 +chr15 68959198 68959238 5S 259 - 68959198 68959238 0 1 40 0 +chr15 69659923 69660012 5S 511 + 69659923 69660012 0 1 89 0 +chr15 72150910 72151008 5S 771 + 72150910 72151008 0 1 98 0 +chr15 78691413 78691455 5S 347 + 78691413 78691455 0 1 42 0 +chr15 79789535 79789574 5S 250 + 79789535 79789574 0 1 39 0 +chr15 83259187 83259229 5S 293 - 83259187 83259229 0 1 42 0 +chr15 86681508 86681573 5S 436 - 86681508 86681573 0 1 65 0 +chr15 88362145 88362252 SSU-rRNA_Hsa 360 + 88362145 88362252 0 1 107 0 +chr15 90305870 90305971 5S 568 + 90305870 90305971 0 1 101 0 +chr15 93963509 93963569 5S 517 - 93963509 93963569 0 1 60 0 +chr15 95459021 95459062 5S 233 + 95459021 95459062 0 1 41 0 +chr15 96351986 96352033 5S 277 + 96351986 96352033 0 1 47 0 +chr15 100614305 100614393 5S 600 - 100614305 100614393 0 1 88 0 +chr15 101811261 101811338 LSU-rRNA_Hsa 491 - 101811261 101811338 0 1 77 0 +chr16 9658265 9658354 5S 745 - 9658265 9658354 0 1 89 0 +chr16 9693945 9694041 5S 593 + 9693945 9694041 0 1 96 0 +chr16 13158240 13158276 5S 248 - 13158240 13158276 0 1 36 0 +chr16 14929243 14929273 5S 232 - 14929243 14929273 0 1 30 0 +chr16 15720306 15720381 5S 394 + 15720306 15720381 0 1 75 0 +chr16 17258195 17258245 5S 322 - 17258195 17258245 0 1 50 0 +chr16 18103585 18103627 5S 328 - 18103585 18103627 0 1 42 0 +chr16 18571787 18571817 5S 229 + 18571787 18571817 0 1 30 0 +chr16 19074480 19074520 5S 261 + 19074480 19074520 0 1 40 0 +chr16 21049820 21049862 5S 274 - 21049820 21049862 0 1 42 0 +chr16 23443673 23443819 LSU-rRNA_Hsa 767 + 23443673 23443819 0 1 146 0 +chr16 23761261 23761349 SSU-rRNA_Hsa 555 - 23761261 23761349 0 1 88 0 +chr16 24424194 24424265 LSU-rRNA_Hsa 400 + 24424194 24424265 0 1 71 0 +chr16 26040232 26040322 5S 738 + 26040232 26040322 0 1 90 0 +chr16 28173466 28173533 LSU-rRNA_Hsa 394 + 28173466 28173533 0 1 67 0 +chr16 29327125 29327170 5S 314 + 29327125 29327170 0 1 45 0 +chr16 29941276 29941461 SSU-rRNA_Hsa 1076 - 29941276 29941461 0 1 185 0 +chr16 33392130 33392171 5S 296 - 33392130 33392171 0 1 41 0 +chr16 33962496 33964361 SSU-rRNA_Hsa 14910 + 33962496 33964361 0 1 1865 0 +chr16 34368170 34368209 5S 254 + 34368170 34368209 0 1 39 0 +chr16 34968517 34968621 5S 307 + 34968517 34968621 0 1 104 0 +chr16 34968777 34968874 5S 372 + 34968777 34968874 0 1 97 0 +chr16 34969018 34969121 5S 293 + 34969018 34969121 0 1 103 0 +chr16 34969279 34969355 5S 349 + 34969279 34969355 0 1 76 0 +chr16 34969504 34969608 5S 353 + 34969504 34969608 0 1 104 0 +chr16 34969750 34969854 5S 433 + 34969750 34969854 0 1 104 0 +chr16 34970001 34970106 5S 372 + 34970001 34970106 0 1 105 0 +chr16 34970262 34970357 5S 277 + 34970262 34970357 0 1 95 0 +chr16 34970529 34970602 5S 364 + 34970529 34970602 0 1 73 0 +chr16 34980140 34980218 5S 327 + 34980140 34980218 0 1 78 0 +chr16 34980366 34980470 5S 378 + 34980366 34980470 0 1 104 0 +chr16 34980664 34980742 5S 375 + 34980664 34980742 0 1 78 0 +chr16 34980914 34981017 5S 384 + 34980914 34981017 0 1 103 0 +chr16 34981192 34981267 5S 407 + 34981192 34981267 0 1 75 0 +chr16 34981409 34981513 5S 346 + 34981409 34981513 0 1 104 0 +chr16 34981710 34981775 5S 287 + 34981710 34981775 0 1 65 0 +chr16 34981934 34982012 5S 360 + 34981934 34982012 0 1 78 0 +chr16 34982150 34982254 5S 333 + 34982150 34982254 0 1 104 0 +chr16 34982430 34982510 5S 251 + 34982430 34982510 0 1 80 0 +chr16 34982691 34982766 5S 334 + 34982691 34982766 0 1 75 0 +chr16 34982950 34983028 5S 386 + 34982950 34983028 0 1 78 0 +chr16 34983174 34983278 5S 390 + 34983174 34983278 0 1 104 0 +chr16 34983425 34983529 5S 291 + 34983425 34983529 0 1 104 0 +chr16 34983686 34983780 5S 331 + 34983686 34983780 0 1 94 0 +chr16 34983931 34984034 5S 333 + 34983931 34984034 0 1 103 0 +chr16 34984183 34984286 5S 382 + 34984183 34984286 0 1 103 0 +chr16 34984438 34984541 5S 411 + 34984438 34984541 0 1 103 0 +chr16 34984719 34984792 5S 316 + 34984719 34984792 0 1 73 0 +chr16 34984967 34985045 5S 318 + 34984967 34985045 0 1 78 0 +chr16 34985215 34985295 5S 393 + 34985215 34985295 0 1 80 0 +chr16 34985469 34985544 5S 307 + 34985469 34985544 0 1 75 0 +chr16 34985737 34985807 5S 259 + 34985737 34985807 0 1 70 0 +chr16 34985975 34986057 5S 402 + 34985975 34986057 0 1 82 0 +chr16 34986231 34986308 5S 386 + 34986231 34986308 0 1 77 0 +chr16 34986456 34986559 5S 318 + 34986456 34986559 0 1 103 0 +chr16 34986729 34986809 5S 283 + 34986729 34986809 0 1 80 0 +chr16 34986979 34987057 5S 339 + 34986979 34987057 0 1 78 0 +chr16 34987228 34987308 5S 400 + 34987228 34987308 0 1 80 0 +chr16 34987697 34987799 5S 284 + 34987697 34987799 0 1 102 0 +chr16 34987948 34988051 5S 368 + 34987948 34988051 0 1 103 0 +chr16 34988199 34988303 5S 363 + 34988199 34988303 0 1 104 0 +chr16 34988452 34988555 5S 316 + 34988452 34988555 0 1 103 0 +chr16 34988703 34988807 5S 273 + 34988703 34988807 0 1 104 0 +chr16 34988986 34989061 5S 403 + 34988986 34989061 0 1 75 0 +chr16 34989330 34989402 5S 262 + 34989330 34989402 0 1 72 0 +chr16 34989572 34989658 5S 334 + 34989572 34989658 0 1 86 0 +chr16 47484276 47484372 5S 665 - 47484276 47484372 0 1 96 0 +chr16 47519472 47519518 LSU-rRNA_Hsa 270 + 47519472 47519518 0 1 46 0 +chr16 47538629 47539297 LSU-rRNA_Hsa 3804 + 47538629 47539297 0 1 668 0 +chr16 47539342 47539430 5S 589 + 47539342 47539430 0 1 88 0 +chr16 48934358 48934400 5S 295 - 48934358 48934400 0 1 42 0 +chr16 50159790 50159852 LSU-rRNA_Hsa 343 - 50159790 50159852 0 1 62 0 +chr16 50903364 50903478 5S 750 - 50903364 50903478 0 1 114 0 +chr16 53371364 53371484 5S 833 + 53371364 53371484 0 1 120 0 +chr16 55758635 55758833 LSU-rRNA_Hsa 344 + 55758635 55758833 0 1 198 0 +chr16 55789820 55789974 LSU-rRNA_Hsa 330 + 55789820 55789974 0 1 154 0 +chr16 55871465 55871650 LSU-rRNA_Hsa 378 - 55871465 55871650 0 1 185 0 +chr16 55875367 55875655 LSU-rRNA_Hsa 596 + 55875367 55875655 0 1 288 0 +chr16 57839543 57839585 5S 269 - 57839543 57839585 0 1 42 0 +chr16 58201281 58201322 5S 308 - 58201281 58201322 0 1 41 0 +chr16 59528153 59528195 5S 253 + 59528153 59528195 0 1 42 0 +chr16 59765258 59765347 5S 744 + 59765258 59765347 0 1 89 0 +chr16 66335711 66335801 5S 760 + 66335711 66335801 0 1 90 0 +chr16 68776381 68776476 5S 731 + 68776381 68776476 0 1 95 0 +chr16 68971728 68971767 5S 256 - 68971728 68971767 0 1 39 0 +chr16 69536817 69536856 5S 514 + 69536817 69536856 0 1 39 0 +chr16 69537146 69537213 5S 514 + 69537146 69537213 0 1 67 0 +chr16 73737987 73738029 5S 332 - 73737987 73738029 0 1 42 0 +chr16 75894943 75895055 5S 641 - 75894943 75895055 0 1 112 0 +chr16 76778887 76778923 5S 270 - 76778887 76778923 0 1 36 0 +chr16 79298350 79298442 5S 681 + 79298350 79298442 0 1 92 0 +chr16 80388720 80388762 5S 279 + 80388720 80388762 0 1 42 0 +chr16 81901992 81902316 LSU-rRNA_Hsa 1832 - 81901992 81902316 0 1 324 0 +chr16 84073550 84073641 5S 668 - 84073550 84073641 0 1 91 0 +chr16 84296442 84296534 5S 673 - 84296442 84296534 0 1 92 0 +chr16 88055914 88055959 5S 311 + 88055914 88055959 0 1 45 0 +chr17 2092238 2092280 5S 338 + 2092238 2092280 0 1 42 0 +chr17 3960098 3960168 5S 299 - 3960098 3960168 0 1 70 0 +chr17 6504281 6504371 5S 770 - 6504281 6504371 0 1 90 0 +chr17 6890783 6890877 5S 640 + 6890783 6890877 0 1 94 0 +chr17 9845155 9845197 5S 250 + 9845155 9845197 0 1 42 0 +chr17 10789615 10789700 5S 659 - 10789615 10789700 0 1 85 0 +chr17 15611350 15611391 LSU-rRNA_Hsa 250 + 15611350 15611391 0 1 41 0 +chr17 15685655 15685729 5S 504 + 15685655 15685729 0 1 74 0 +chr17 19355538 19356096 LSU-rRNA_Hsa 1949 + 19355538 19356096 0 1 558 0 +chr17 19356672 19356747 LSU-rRNA_Hsa 368 + 19356672 19356747 0 1 75 0 +chr17 19356745 19356850 LSU-rRNA_Hsa 344 + 19356745 19356850 0 1 105 0 +chr17 19356936 19357097 LSU-rRNA_Hsa 600 + 19356936 19357097 0 1 161 0 +chr17 19901006 19901089 5S 611 + 19901006 19901089 0 1 83 0 +chr17 22023344 22023500 LSU-rRNA_Hsa 226 + 22023344 22023500 0 1 156 0 +chr17 28909257 28909340 5S 592 + 28909257 28909340 0 1 83 0 +chr17 29606328 29606370 5S 276 + 29606328 29606370 0 1 42 0 +chr17 30290872 30290952 5S 513 - 30290872 30290952 0 1 80 0 +chr17 30919112 30919237 LSU-rRNA_Hsa 813 - 30919112 30919237 0 1 125 0 +chr17 32447099 32447187 5S 514 - 32447099 32447187 0 1 88 0 +chr17 32820399 32820532 LSU-rRNA_Hsa 304 + 32820399 32820532 0 1 133 0 +chr17 33478114 33478275 LSU-rRNA_Hsa 1273 - 33478114 33478275 0 1 161 0 +chr17 33478275 33478372 LSU-rRNA_Hsa 670 - 33478275 33478372 0 1 97 0 +chr17 34847075 34847166 5S 498 - 34847075 34847166 0 1 91 0 +chr17 36300286 36300335 5S 336 - 36300286 36300335 0 1 49 0 +chr17 36888052 36888173 5S 1010 - 36888052 36888173 0 1 121 0 +chr17 38383641 38383708 LSU-rRNA_Hsa 467 + 38383641 38383708 0 1 67 0 +chr17 38530341 38530409 5S 384 + 38530341 38530409 0 1 68 0 +chr17 39874405 39874495 5S 698 + 39874405 39874495 0 1 90 0 +chr17 42673610 42673649 LSU-rRNA_Hsa 272 + 42673610 42673649 0 1 39 0 +chr17 43404773 43404863 5S 692 - 43404773 43404863 0 1 90 0 +chr17 43635020 43635062 5S 329 - 43635020 43635062 0 1 42 0 +chr17 44017647 44017689 5S 247 + 44017647 44017689 0 1 42 0 +chr17 44582718 44582760 5S 311 + 44582718 44582760 0 1 42 0 +chr17 47693433 47693475 5S 298 + 47693433 47693475 0 1 42 0 +chr17 50979465 50979505 5S 258 + 50979465 50979505 0 1 40 0 +chr17 53056945 53056987 5S 308 + 53056945 53056987 0 1 42 0 +chr17 55369202 55369244 5S 333 + 55369202 55369244 0 1 42 0 +chr17 55868618 55868752 LSU-rRNA_Hsa 952 - 55868618 55868752 0 1 134 0 +chr17 56804099 56804142 5S 313 - 56804099 56804142 0 1 43 0 +chr17 57007389 57007431 5S 302 + 57007389 57007431 0 1 42 0 +chr17 58080072 58080121 5S 319 + 58080072 58080121 0 1 49 0 +chr17 58117390 58117478 LSU-rRNA_Hsa 239 + 58117390 58117478 0 1 88 0 +chr17 58117741 58117829 LSU-rRNA_Hsa 284 - 58117741 58117829 0 1 88 0 +chr17 58457576 58457625 5S 318 + 58457576 58457625 0 1 49 0 +chr17 60502545 60502623 LSU-rRNA_Hsa 402 - 60502545 60502623 0 1 78 0 +chr17 61706867 61706923 LSU-rRNA_Hsa 420 + 61706867 61706923 0 1 56 0 +chr17 62106847 62106884 5S 234 + 62106847 62106884 0 1 37 0 +chr17 62900683 62900725 5S 329 - 62900683 62900725 0 1 42 0 +chr17 64263860 64263949 5S 607 + 64263860 64263949 0 1 89 0 +chr17 64635386 64635465 5S 526 + 64635386 64635465 0 1 79 0 +chr17 64891609 64891687 5S 322 + 64891609 64891687 0 1 78 0 +chr17 65264225 65264345 5S 683 + 65264225 65264345 0 1 120 0 +chr17 69003154 69003222 5S 454 - 69003154 69003222 0 1 68 0 +chr17 70863796 70863886 LSU-rRNA_Hsa 283 + 70863796 70863886 0 1 90 0 +chr17 71183663 71183713 LSU-rRNA_Hsa 243 - 71183663 71183713 0 1 50 0 +chr17 72413752 72413843 5S 724 - 72413752 72413843 0 1 91 0 +chr17 75158031 75158389 LSU-rRNA_Hsa 2011 - 75158031 75158389 0 1 358 0 +chr18 9844756 9844826 5S 534 - 9844756 9844826 0 1 70 0 +chr18 9923915 9923999 5S 612 + 9923915 9923999 0 1 84 0 +chr18 13407509 13407554 5S 262 + 13407509 13407554 0 1 45 0 +chr18 19508948 19509055 5S 532 - 19508948 19509055 0 1 107 0 +chr18 19856796 19856861 LSU-rRNA_Hsa 443 - 19856796 19856861 0 1 65 0 +chr18 19872248 19872290 5S 344 - 19872248 19872290 0 1 42 0 +chr18 21191673 21191827 LSU-rRNA_Hsa 1095 + 21191673 21191827 0 1 154 0 +chr18 21750466 21750587 5S 906 - 21750466 21750587 0 1 121 0 +chr18 21868883 21868956 5S 506 + 21868883 21868956 0 1 73 0 +chr18 29348701 29348779 LSU-rRNA_Hsa 291 - 29348701 29348779 0 1 78 0 +chr18 29756010 29756130 5S 723 - 29756010 29756130 0 1 120 0 +chr18 36530250 36530358 LSU-rRNA_Hsa 564 - 36530250 36530358 0 1 108 0 +chr18 39850553 39850643 5S 487 + 39850553 39850643 0 1 90 0 +chr18 41651547 41651667 5S 842 + 41651547 41651667 0 1 120 0 +chr18 43516369 43516411 LSU-rRNA_Hsa 240 + 43516369 43516411 0 1 42 0 +chr18 46001883 46001971 5S 583 - 46001883 46001971 0 1 88 0 +chr18 46259319 46259362 5S 293 - 46259319 46259362 0 1 43 0 +chr18 47472670 47472758 5S 680 - 47472670 47472758 0 1 88 0 +chr18 47479435 47479473 5S 242 - 47479435 47479473 0 1 38 0 +chr18 47845373 47845466 5S 487 + 47845373 47845466 0 1 93 0 +chr18 48287957 48288132 LSU-rRNA_Hsa 322 - 48287957 48288132 0 1 175 0 +chr18 52813795 52813876 5S 400 - 52813795 52813876 0 1 81 0 +chr18 54460379 54460421 5S 302 + 54460379 54460421 0 1 42 0 +chr18 57379953 57379994 5S 289 - 57379953 57379994 0 1 41 0 +chr18 58715935 58716021 LSU-rRNA_Hsa 251 - 58715935 58716021 0 1 86 0 +chr18 63142748 63142836 5S 512 + 63142748 63142836 0 1 88 0 +chr18 63212159 63212201 5S 297 - 63212159 63212201 0 1 42 0 +chr18 67339199 67339241 5S 275 + 67339199 67339241 0 1 42 0 +chr18 70419230 70419285 5S 393 + 70419230 70419285 0 1 55 0 +chr18 72244399 72244658 LSU-rRNA_Hsa 639 - 72244399 72244658 0 1 259 0 +chr18 72245076 72245117 5S 319 + 72245076 72245117 0 1 41 0 +chr18 75575443 75575523 5S 366 - 75575443 75575523 0 1 80 0 +chr18 77772846 77773065 LSU-rRNA_Hsa 1581 + 77772846 77773065 0 1 219 0 +chr19 453135 453224 5S 462 + 453135 453224 0 1 89 0 +chr19 7951860 7951980 5S 870 - 7951860 7951980 0 1 120 0 +chr19 10778407 10778561 LSU-rRNA_Hsa 780 + 10778407 10778561 0 1 154 0 +chr19 12107629 12107733 5S 532 + 12107629 12107733 0 1 104 0 +chr19 12138726 12138836 5S 485 - 12138726 12138836 0 1 110 0 +chr19 12180984 12181087 5S 438 + 12180984 12181087 0 1 103 0 +chr19 12217314 12217431 5S 436 + 12217314 12217431 0 1 117 0 +chr19 12261920 12262002 5S 332 - 12261920 12262002 0 1 82 0 +chr19 18082834 18082881 5S 320 + 18082834 18082881 0 1 47 0 +chr19 19818692 19818767 5S 326 + 19818692 19818767 0 1 75 0 +chr19 21295931 21296041 5S 640 - 21295931 21296041 0 1 110 0 +chr19 22877614 22877658 SSU-rRNA_Hsa 327 - 22877614 22877658 0 1 44 0 +chr19 22877654 22877696 SSU-rRNA_Hsa 350 - 22877654 22877696 0 1 42 0 +chr19 24182398 24182565 LSU-rRNA_Hsa 1157 - 24182398 24182565 0 1 167 0 +chr19 24182635 24183468 LSU-rRNA_Hsa 4863 - 24182635 24183468 0 1 833 0 +chr19 24183459 24184250 LSU-rRNA_Hsa 4492 - 24183459 24184250 0 1 791 0 +chr19 24184241 24186210 LSU-rRNA_Hsa 10822 - 24184241 24186210 0 1 1969 0 +chr19 29492573 29492663 5S 517 + 29492573 29492663 0 1 90 0 +chr19 32146299 32146367 5S 440 - 32146299 32146367 0 1 68 0 +chr19 32734868 32734979 5S 809 - 32734868 32734979 0 1 111 0 +chr19 33501932 33501973 5S 292 + 33501932 33501973 0 1 41 0 +chr19 34507782 34507824 5S 336 - 34507782 34507824 0 1 42 0 +chr19 34628205 34628247 5S 288 - 34628205 34628247 0 1 42 0 +chr19 35143448 35143490 5S 310 - 35143448 35143490 0 1 42 0 +chr19 36066505 36066675 LSU-rRNA_Hsa 1406 + 36066505 36066675 0 1 170 0 +chr19 36066690 36066749 LSU-rRNA_Hsa 509 + 36066690 36066749 0 1 59 0 +chr19 42069989 42070190 LSU-rRNA_Hsa 775 - 42069989 42070190 0 1 201 0 +chr19 42070201 42070694 LSU-rRNA_Hsa 3059 - 42070201 42070694 0 1 493 0 +chr19 42070722 42070820 LSU-rRNA_Hsa 3059 - 42070722 42070820 0 1 98 0 +chr19 42070848 42071297 LSU-rRNA_Hsa 1628 - 42070848 42071297 0 1 449 0 +chr19 42071435 42071891 LSU-rRNA_Hsa 729 - 42071435 42071891 0 1 456 0 +chr19 43910305 43911078 LSU-rRNA_Hsa 5272 + 43910305 43911078 0 1 773 0 +chr19 43911248 43911354 LSU-rRNA_Hsa 5272 + 43911248 43911354 0 1 106 0 +chr19 43911665 43912167 LSU-rRNA_Hsa 5272 + 43911665 43912167 0 1 502 0 +chr19 44326047 44326088 5S 242 + 44326047 44326088 0 1 41 0 +chr19 46735611 46736114 LSU-rRNA_Hsa 914 - 46735611 46736114 0 1 503 0 +chr19 47511978 47512019 5S 242 - 47511978 47512019 0 1 41 0 +chr19 49160046 49160136 5S 588 - 49160046 49160136 0 1 90 0 +chr19 51654204 51654248 5S 309 - 51654204 51654248 0 1 44 0 +chr19 52286862 52286922 LSU-rRNA_Hsa 369 + 52286862 52286922 0 1 60 0 +chr19 52333773 52333826 LSU-rRNA_Hsa 247 + 52333773 52333826 0 1 53 0 +chr19 52571511 52571601 5S 632 + 52571511 52571601 0 1 90 0 +chr19 52621010 52621090 5S 463 + 52621010 52621090 0 1 80 0 +chr19 54128140 54128184 5S 258 - 54128140 54128184 0 1 44 0 +chr19 54158223 54158402 LSU-rRNA_Hsa 992 - 54158223 54158402 0 1 179 0 +chr19 58093132 58093265 LSU-rRNA_Hsa 553 - 58093132 58093265 0 1 133 0 +chr19 58378630 58378720 5S 789 + 58378630 58378720 0 1 90 0 +chr19 58874864 58874939 5S 502 + 58874864 58874939 0 1 75 0 +chr20 5079032 5079121 5S 644 - 5079032 5079121 0 1 89 0 +chr20 15261429 15261513 5S 582 - 15261429 15261513 0 1 84 0 +chr20 15933519 15933569 5S 289 + 15933519 15933569 0 1 50 0 +chr20 17469657 17470083 LSU-rRNA_Hsa 1383 + 17469657 17470083 0 1 426 0 +chr20 18414485 18414573 5S 536 + 18414485 18414573 0 1 88 0 +chr20 18696136 18696179 5S 244 - 18696136 18696179 0 1 43 0 +chr20 21119591 21119713 5S 780 - 21119591 21119713 0 1 122 0 +chr20 21465225 21465316 5S 651 - 21465225 21465316 0 1 91 0 +chr20 22765836 22765878 5S 289 - 22765836 22765878 0 1 42 0 +chr20 23141492 23141601 5S 689 - 23141492 23141601 0 1 109 0 +chr20 23361531 23361649 5S 724 - 23361531 23361649 0 1 118 0 +chr20 23946334 23946385 5S 290 - 23946334 23946385 0 1 51 0 +chr20 29944672 29944761 5S 589 + 29944672 29944761 0 1 89 0 +chr20 30596178 30596240 5S 545 + 30596178 30596240 0 1 62 0 +chr20 30638390 30638508 5S 726 + 30638390 30638508 0 1 118 0 +chr20 30953215 30953258 5S 354 - 30953215 30953258 0 1 43 0 +chr20 32430069 32430117 5S 389 - 32430069 32430117 0 1 48 0 +chr20 33783108 33783226 5S 731 + 33783108 33783226 0 1 118 0 +chr20 39482778 39482869 5S 600 - 39482778 39482869 0 1 91 0 +chr20 41168027 41168067 5S 301 + 41168027 41168067 0 1 40 0 +chr20 44188394 44188511 5S 814 - 44188394 44188511 0 1 117 0 +chr20 45112773 45112879 LSU-rRNA_Hsa 667 - 45112773 45112879 0 1 106 0 +chr20 46501940 46501997 5S 393 + 46501940 46501997 0 1 57 0 +chr20 49421151 49421193 5S 248 - 49421151 49421193 0 1 42 0 +chr20 54780137 54780229 5S 532 - 54780137 54780229 0 1 92 0 +chr21 9827004 9827578 SSU-rRNA_Hsa 5116 + 9827004 9827578 0 1 574 0 +chr21 14688012 14688049 5S 231 + 14688012 14688049 0 1 37 0 +chr21 15443191 15443309 5S 501 + 15443191 15443309 0 1 118 0 +chr21 15456972 15457500 LSU-rRNA_Hsa 2854 - 15456972 15457500 0 1 528 0 +chr21 15457498 15457585 LSU-rRNA_Hsa 481 - 15457498 15457585 0 1 87 0 +chr21 19374787 19374922 LSU-rRNA_Hsa 347 - 19374787 19374922 0 1 135 0 +chr21 20426587 20426628 5S 247 + 20426587 20426628 0 1 41 0 +chr21 26479053 26479094 5S 229 + 26479053 26479094 0 1 41 0 +chr21 26574520 26574610 5S 659 + 26574520 26574610 0 1 90 0 +chr21 27228058 27228147 SSU-rRNA_Hsa 699 + 27228058 27228147 0 1 89 0 +chr21 30580386 30580428 5S 256 - 30580386 30580428 0 1 42 0 +chr21 31154796 31155001 SSU-rRNA_Hsa 239 + 31154796 31155001 0 1 205 0 +chr21 33856169 33856215 5S 332 - 33856169 33856215 0 1 46 0 +chr21 33935387 33935474 5S 621 + 33935387 33935474 0 1 87 0 +chr21 34279597 34279698 LSU-rRNA_Hsa 487 + 34279597 34279698 0 1 101 0 +chr21 37012236 37012277 5S 250 + 37012236 37012277 0 1 41 0 +chr21 38224210 38224329 5S 537 + 38224210 38224329 0 1 119 0 +chr21 38636344 38636412 LSU-rRNA_Hsa 248 + 38636344 38636412 0 1 68 0 +chr21 39001381 39001423 5S 289 - 39001381 39001423 0 1 42 0 +chr21 39194580 39194623 5S 299 + 39194580 39194623 0 1 43 0 +chr21 41300088 41300129 5S 269 + 41300088 41300129 0 1 41 0 +chr21 43641286 43641397 5S 474 + 43641286 43641397 0 1 111 0 +chr21 45128124 45128187 LSU-rRNA_Hsa 244 - 45128124 45128187 0 1 63 0 +chr22 18105844 18105904 LSU-rRNA_Hsa 372 - 18105844 18105904 0 1 60 0 +chr22 21265391 21265525 LSU-rRNA_Hsa 904 + 21265391 21265525 0 1 134 0 +chr22 22146728 22146810 5S 668 + 22146728 22146810 0 1 82 0 +chr22 22210544 22210651 LSU-rRNA_Hsa 669 + 22210544 22210651 0 1 107 0 +chr22 22210670 22210856 LSU-rRNA_Hsa 833 + 22210670 22210856 0 1 186 0 +chr22 23469876 23469918 5S 226 - 23469876 23469918 0 1 42 0 +chr22 23697966 23698141 LSU-rRNA_Hsa 407 + 23697966 23698141 0 1 175 0 +chr22 23757599 23757699 5S 343 + 23757599 23757699 0 1 100 0 +chr22 24253628 24253709 5S 656 - 24253628 24253709 0 1 81 0 +chr22 25515263 25515312 5S 291 + 25515263 25515312 0 1 49 0 +chr22 26111045 26111136 5S 693 - 26111045 26111136 0 1 91 0 +chr22 26786620 26786748 5S 646 - 26786620 26786748 0 1 128 0 +chr22 30335677 30335719 5S 263 - 30335677 30335719 0 1 42 0 +chr22 31701389 31701479 5S 627 + 31701389 31701479 0 1 90 0 +chr22 33031095 33031184 5S 592 - 33031095 33031184 0 1 89 0 +chr22 33816270 33816312 5S 316 - 33816270 33816312 0 1 42 0 +chr22 36713014 36713053 5S 249 + 36713014 36713053 0 1 39 0 +chr22 36713067 36713106 5S 265 + 36713067 36713106 0 1 39 0 +chr22 36713120 36713159 5S 281 + 36713120 36713159 0 1 39 0 +chr22 39644733 39644831 5S 398 + 39644733 39644831 0 1 98 0 +chr22 41043647 41043689 5S 290 + 41043647 41043689 0 1 42 0 +chr22 42530233 42530285 5S 355 - 42530233 42530285 0 1 52 0 +chr6_apd_hap1 1033560 1034108 LSU-rRNA_Hsa 301 - 1033560 1034108 0 1 548 0 +chr6_apd_hap1 3361052 3361144 5S 563 - 3361052 3361144 0 1 92 0 +chr6_cox_hap2 1246022 1246134 LSU-rRNA_Hsa 257 - 1246022 1246134 0 1 112 0 +chr6_cox_hap2 2707816 2707855 SSU-rRNA_Hsa 233 + 2707816 2707855 0 1 39 0 +chr6_cox_hap2 3516979 3517071 5S 563 - 3516979 3517071 0 1 92 0 +chr6_dbb_hap3 1030728 1031276 LSU-rRNA_Hsa 364 - 1030728 1031276 0 1 548 0 +chr6_dbb_hap3 2490183 2490222 SSU-rRNA_Hsa 233 + 2490183 2490222 0 1 39 0 +chr6_dbb_hap3 3325527 3325619 5S 563 - 3325527 3325619 0 1 92 0 +chr6_mcf_hap5 1030394 1030506 LSU-rRNA_Hsa 307 - 1030394 1030506 0 1 112 0 +chr6_mcf_hap5 2575098 2575137 SSU-rRNA_Hsa 229 + 2575098 2575137 0 1 39 0 +chr6_mcf_hap5 3426152 3426244 5S 563 - 3426152 3426244 0 1 92 0 +chr6_qbl_hap6 1030713 1031261 LSU-rRNA_Hsa 364 - 1030713 1031261 0 1 548 0 +chr6_qbl_hap6 2488966 2489005 SSU-rRNA_Hsa 233 + 2488966 2489005 0 1 39 0 +chr6_qbl_hap6 3307336 3307428 5S 563 - 3307336 3307428 0 1 92 0 +chr6_mann_hap4 1030358 1030906 LSU-rRNA_Hsa 364 - 1030358 1030906 0 1 548 0 +chr6_mann_hap4 2541448 2541487 SSU-rRNA_Hsa 233 + 2541448 2541487 0 1 39 0 +chr6_mann_hap4 3389161 3389253 5S 563 - 3389161 3389253 0 1 92 0 +chr6_ssto_hap7 1067592 1068140 LSU-rRNA_Hsa 363 - 1067592 1068140 0 1 548 0 +chr6_ssto_hap7 2528009 2528048 SSU-rRNA_Hsa 229 + 2528009 2528048 0 1 39 0 +chr6_ssto_hap7 2773921 2774104 LSU-rRNA_Hsa 233 + 2773921 2774104 0 1 183 0 +chrUn_gl000220 95180 95223 LSU-rRNA_Hsa 519 + 95180 95223 0 1 43 0 +chrUn_gl000220 95530 95616 LSU-rRNA_Hsa 519 + 95530 95616 0 1 86 0 +chrUn_gl000220 95614 96145 LSU-rRNA_Hsa 2585 + 95614 96145 0 1 531 0 +chrUn_gl000220 99158 99197 LSU-rRNA_Hsa 239 + 99158 99197 0 1 39 0 +chrUn_gl000220 109077 110946 SSU-rRNA_Hsa 15708 + 109077 110946 0 1 1869 0 +chrUn_gl000220 113347 114110 LSU-rRNA_Hsa 37124 + 113347 114110 0 1 763 0 +chrUn_gl000220 114132 114194 LSU-rRNA_Hsa 37124 + 114132 114194 0 1 62 0 +chrUn_gl000220 114238 115498 LSU-rRNA_Hsa 37124 + 114238 115498 0 1 1260 0 +chrUn_gl000220 115521 116829 LSU-rRNA_Hsa 37124 + 115521 116829 0 1 1308 0 +chrUn_gl000220 116861 118417 LSU-rRNA_Hsa 37124 + 116861 118417 0 1 1556 0 +chrUn_gl000220 153049 154918 SSU-rRNA_Hsa 15708 + 153049 154918 0 1 1869 0 +chrUn_gl000220 157319 158082 LSU-rRNA_Hsa 32456 + 157319 158082 0 1 763 0 +chrUn_gl000220 158104 158166 LSU-rRNA_Hsa 32456 + 158104 158166 0 1 62 0 +chrUn_gl000220 158210 159470 LSU-rRNA_Hsa 32456 + 158210 159470 0 1 1260 0 +chrUn_gl000220 159493 160801 LSU-rRNA_Hsa 32456 + 159493 160801 0 1 1308 0 +chrUn_gl000220 160833 161802 LSU-rRNA_Hsa 32456 + 160833 161802 0 1 969 0 +chrUn_gl000223 58453 58538 5S 650 + 58453 58538 0 1 85 0 +chrUn_gl000228 20112 20232 5S 693 + 20112 20232 0 1 120 0 +chrUn_gl000228 22673 22794 5S 802 + 22673 22794 0 1 121 0 +chrUn_gl000229 18170 19913 SSU-rRNA_Hsa 13464 + 18170 19913 0 1 1743 0 +chr17_ctg5_hap1 19909 19999 5S 692 - 19909 19999 0 1 90 0 +chr17_ctg5_hap1 247970 248012 5S 325 - 247970 248012 0 1 42 0 +chr17_ctg5_hap1 465905 465947 5S 329 - 465905 465947 0 1 42 0 +chr17_ctg5_hap1 1439558 1439600 5S 332 + 1439558 1439600 0 1 42 0 +chr1_gl000192_random 415328 415417 5S 637 + 415328 415417 0 1 89 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.ReadLen_plot.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.readlen_profile.png",width=500,height=500,units="px") +readlen_val=c(67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100) +readlen_count=c(220,212,287,315,327,323,420,437,447,422,435,429,427,487,438,487,492,492,518,536,517,565,503,550,723,808,803,859,881,927,945,1535,1897,44685) +plot(readlen_val,(readlen_count/77686),pch=20,xlab="Mapped Read Length",ylab="Proportion",col="blue") +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.TransCoverage.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,10 @@ +png('/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.TransCoverage.png',width=500,height=500,units='px') 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+Fn = ecdf(a) +max_x = round(log(max(knots(Fn)),2),0) +xx = c(0,2^seq(0,max_x,by=2)) +y=Fn(xx) +xlog = log(xx[2:length(xx)],base=2) +plot(x=c(-1,xlog),y=y,xaxt = 'n',type="b",col="blue",pch=20,xlab="Number of Reads",ylab="Cumulative proportion of Genes") +axis(1,at = c(-1,seq(0,max_x,by=2)),labels=c(0,2^seq(0,max_x,by=2))) +dev.state = dev.off() \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.clipping_profile.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.clipping_profile.png",width=500,height=500,units="px") +read_pos=c(0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99) +count=c(10290,9294,8453,7955,7448,6951,6512,6050,5602,5219,4931,4682,4396,4114,3827,3540,3283,3032,2781,2555,2301,2073,1849,1638,1411,1212,1012,799,634,485,341,201,104,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,108,203,338,496,660,807,995,1203,1420,1604,1824,2020,2220,2460,2668,2901,3139,3379,3631,3895,4137,4426,4691,4976,5369,5810,6205,6686,7174,7678,8224,9087,10073) +plot(read_pos,1-(count/77686),pch=20,xlab="Position of reads",ylab="Mappability",col="blue") +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.clipping_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,101 @@ +Position Read_Total Read_clipped +0 77686 10290 +1 77686 9294 +2 77686 8453 +3 77686 7955 +4 77686 7448 +5 77686 6951 +6 77686 6512 +7 77686 6050 +8 77686 5602 +9 77686 5219 +10 77686 4931 +11 77686 4682 +12 77686 4396 +13 77686 4114 +14 77686 3827 +15 77686 3540 +16 77686 3283 +17 77686 3032 +18 77686 2781 +19 77686 2555 +20 77686 2301 +21 77686 2073 +22 77686 1849 +23 77686 1638 +24 77686 1411 +25 77686 1212 +26 77686 1012 +27 77686 799 +28 77686 634 +29 77686 485 +30 77686 341 +31 77686 201 +32 77686 104 +33 77686 0 +34 77686 0 +35 77686 0 +36 77686 0 +37 77686 0 +38 77686 0 +39 77686 0 +40 77686 0 +41 77686 0 +42 77686 0 +43 77686 0 +44 77686 0 +45 77686 0 +46 77686 0 +47 77686 0 +48 77686 0 +49 77686 0 +50 77686 0 +51 77686 0 +52 77686 0 +53 77686 0 +54 77686 0 +55 77686 0 +56 77686 0 +57 77686 0 +58 77686 0 +59 77686 0 +60 77686 0 +61 77686 0 +62 77686 0 +63 77686 0 +64 77686 0 +65 77686 0 +66 77686 0 +67 77686 108 +68 77686 203 +69 77686 338 +70 77686 496 +71 77686 660 +72 77686 807 +73 77686 995 +74 77686 1203 +75 77686 1420 +76 77686 1604 +77 77686 1824 +78 77686 2020 +79 77686 2220 +80 77686 2460 +81 77686 2668 +82 77686 2901 +83 77686 3139 +84 77686 3379 +85 77686 3631 +86 77686 3895 +87 77686 4137 +88 77686 4426 +89 77686 4691 +90 77686 4976 +91 77686 5369 +92 77686 5810 +93 77686 6205 +94 77686 6686 +95 77686 7174 +96 77686 7678 +97 77686 8224 +98 77686 9087 +99 77686 10073
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.geneAbundance.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,27321 @@ +gene Counts +AADACL3 0 +AADACL4 0 +ABCD3 1 +ACADM 0 +ACKR1 0 +ACOT11 0 +ACTG1P4 0 +ACTL8 172 +ACTN2 0 +ACTRT2 0 +ADAM15 0 +ADAMTSL4 0 +ADCK3 0 +ADORA1 0 +ADPRHL2 0 +AGL 0 +AGO1 0 +AGO3 0 +AGO4 0 +AGRN 0 +AGTRAP 0 +AHCYL1 2 +AJAP1 0 +AK4 2 +AK5 0 +AKIRIN1 5 +AKR1A1 0 +AKR7A2P1 0 +ALG6 0 +ALPL 0 +AMPD2 1 +AMY1A 0 +AMY1B 0 +AMY1C 0 +AMY2A 0 +AMY2B 0 +ANGPTL3 0 +ANGPTL7 0 +ANKRD34A 0 +ANKRD35 0 +ANXA9 0 +AP4B1-AS1 0 +APCS 0 +APITD1 5 +APITD1-CORT 8 +APOA1BP 0 +AQP10 0 +ARF1 17 +ARHGEF10L 0 +ARHGEF16 1 +ARID1A 20 +ARTN 0 +ARV1 0 +ASH1L-AS1 0 +ATAD3A 0 +ATAD3B 0 +ATAD3C 2 +ATF3 0 +ATF6 4 +ATG4C 1 +ATP1A1 22 +ATP1A2 0 +ATP1A4 0 +ATP1B1 9 +ATP2B4 12 +ATP5F1 1 +ATP6V0B 0 +ATP8B2 0 +ATPIF1 0 +ATXN7L2 1 +AVPR1B 0 +AXDND1 0 +AZIN2 1 +B3GALT6 0 +B4GALT2 0 +BCAN 0 +BCL9 2 +BECN1P1 0 +BGLAP 0 +BLZF1 0 +BMP8A 0 +BNIPL 0 +BOLA1 1 +BRDT 6 +BRINP2 0 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+PNMA5 0 +PNPLA4 0 +POF1B 0 +PPEF1-AS1 0 +PPP1R2P9 0 +PPP2R3B 0 +PRAF2 0 +PRICKLE3 0 +PRKX 1 +PSMD10 4 +PTCHD1-AS 0 +RAB39B 0 +RAB40A 0 +RAB9B 0 +RAI2 0 +RAP2C 1 +RBBP7 55 +RBM41 1 +RBMX 6 +RENBP 0 +RGAG4 0 +RHOXF1 0 +RHOXF2 0 +RHOXF2B 0 +RIPPLY1 0 +RLIM 7 +RNF113A 2 +RNU6-2 0 +RNU6-28P 0 +RP11-87M18.2 0 +RPGR 2 +RPL39 4 +RPS4X 16 +RPS6KA3 0 +RPS6KA6 0 +RS1 0 +SATL1 0 +SCARNA9L 0 +SCML2 0 +SEPT6 0 +SERPINA7 0 +SH3KBP1 13 +SHROOM4 0 +SLC10A3 1 +SLC25A5-AS1 0 +SLC25A53 0 +SLC25A6 0 +SLC35A2 0 +SLC38A5 0 +SLC7A3 0 +SLC9A7 2 +SLITRK4 0 +SMARCA1 0 +SMC1A 2 +SMEK3P 0 +SMIM9 0 +SMPX 0 +SNORA11D 0 +SNORA11E 0 +SNORA69 0 +SNORD61 0 +SNORD96B 0 +SNX12 2 +SOX3 0 +SPANXA1 0 +SPANXA2 0 +SPANXC 0 +SPANXD 0 +SPANXN2 0 +SPANXN3 0 +SPANXN5 0 +SPIN2A 0 +SPIN2B 0 +SPIN3 4 +SPIN4 0 +SRPX 0 +SSX2 0 +SSX2B 0 +SSX3 0 +SSX4 0 +SSX4B 0 +SSX5 0 +SSX7 0 +SSX9 0 +SUPT20HL2 0 +SYN1 0 +SYP 0 +SYTL4 2 +TAB3 1 +TAF7L 0 +TAF9B 0 +TCEAL5 0 +TCEAL6 0 +TCEAL8 0 +TCP11X2 0 +TENM1 0 +TEX11 0 +TEX13A 0 +TEX13B 0 +TEX28 0 +TFDP3 0 +TFE3 4 +THOC2 67 +TIMM17B 1 +TIMM8A 0 +TLR8-AS1 0 +TMEM185A 0 +TMEM255A 0 +TMEM27 0 +TMEM47 0 +TMLHE 0 +TMLHE-AS1 0 +TMSB15A 0 +TRAPPC2 1 +TREX2 0 +TRMT2B 0 +TRPC5 0 +TSC22D3 0 +TSPAN6 0 +TTC3P1 0 +UBL4A 0 +UPF3B 3 +UQCRBP1 0 +USP26 0 +USP27X-AS1 0 +USP51 0 +UXT 0 +VCX2 0 +VCX3A 0 +VSIG4 0 +WDR45 0 +WNK3 1 +XAGE1B 0 +XAGE1E 0 +XAGE2 0 +XAGE3 0 +XIST 0 +XKRX 0 +XRCC6P5 0 +ZBED1 0 +ZC4H2 0 +ZCCHC5 0 +ZDHHC15 0 +ZDHHC9 0 +ZFX-AS1 0 +ZMAT1 0 +ZMYM3 1 +ZNF182 5 +ZNF280C 12 +ZNF41 0 +ZNF630 0 +ZNF674 0 +ZNF75D 0 +ZXDA 0 +AMELY 0 +ASMTL 0 +BCORP1 0 +BPY2 0 +BPY2B 0 +BPY2C 0 +CD24 0 +CDY1 0 +CDY1B 0 +CDY2A 0 +CDY2B 0 +CRLF2 0 +CSPG4P1Y 0 +DAZ1 0 +DAZ3 0 +DAZ4 0 +DDX11L16 0 +DHRSX 0 +FAM197Y2 0 +FAM197Y5 0 +FAM224A 0 +FAM224B 0 +FAM41AY1 0 +FAM41AY2 0 +GOLGA2P2Y 0 +GOLGA2P3Y 0 +GTPBP6 0 +GYG2P1 0 +HSFY1 0 +HSFY2 0 +KDM5D 0 +LINC00280 0 +LOC101929148 0 +NCRNA00185 0 +NLGN4Y-AS1 0 +P2RY8 0 +PPP2R3B 0 +PRORY 0 +PRY 0 +PRY2 0 +RBMY1A1 0 +RBMY1A3P 0 +RBMY1B 0 +RBMY1D 0 +RBMY1E 0 +RBMY1F 0 +RBMY1J 0 +RBMY2EP 0 +RBMY3AP 0 +SLC25A6 0 +SRY 0 +TTTY1 0 +TTTY10 0 +TTTY11 0 +TTTY13 0 +TTTY14 0 +TTTY16 0 +TTTY17A 0 +TTTY17B 0 +TTTY17C 0 +TTTY18 0 +TTTY1B 0 +TTTY2 0 +TTTY20 0 +TTTY21 0 +TTTY21B 0 +TTTY23 0 +TTTY23B 0 +TTTY2B 0 +TTTY3 0 +TTTY3B 0 +TTTY4 0 +TTTY4B 0 +TTTY4C 0 +TTTY5 0 +TTTY6 0 +TTTY6B 0 +TTTY7 0 +TTTY7B 0 +TTTY8 0 +TTTY8B 0 +TTTY9A 0 +TTTY9B 0 +UTY 0 +VCY 0 +VCY1B 0 +XKRY 0 +XKRY2 0 +ZBED1 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.geneBodyCoverage.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,104 @@ +Total reads: 77686 +Fragment number: 49058 +percentile count +0 194 +1 396 +2 581 +3 734 +4 832 +5 892 +6 1002 +7 1069 +8 1105 +9 1181 +10 1242 +11 1183 +12 1154 +13 1288 +14 1353 +15 1327 +16 1235 +17 1250 +18 1297 +19 1373 +20 1405 +21 1401 +22 1412 +23 1430 +24 1406 +25 1438 +26 1485 +27 1524 +28 1512 +29 1499 +30 1528 +31 1496 +32 1466 +33 1408 +34 1392 +35 1430 +36 1394 +37 1369 +38 1373 +39 1408 +40 1487 +41 1466 +42 1455 +43 1493 +44 1461 +45 1429 +46 1461 +47 1496 +48 1449 +49 1476 +50 1466 +51 1447 +52 1440 +53 1473 +54 1503 +55 1581 +56 1606 +57 1587 +58 1605 +59 1584 +60 1609 +61 1688 +62 1685 +63 1694 +64 1665 +65 1732 +66 1750 +67 1802 +68 1891 +69 1926 +70 1939 +71 1951 +72 1927 +73 1902 +74 1933 +75 1938 +76 1990 +77 1996 +78 1988 +79 2008 +80 2022 +81 2049 +82 2036 +83 2017 +84 2016 +85 2032 +86 2004 +87 2015 +88 2020 +89 2070 +90 2118 +91 2144 +92 2161 +93 2117 +94 2084 +95 2056 +96 1916 +97 1797 +98 1488 +99 963 +100 285
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.geneBodyCoverage_plot.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,6 @@ +png('/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.geneBodyCoverage.png',width=500,height=500,units='px') +x=c(0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100) +y=c(194,396,581,734,832,892,1002,1069,1105,1181,1242,1183,1154,1288,1353,1327,1235,1250,1297,1373,1405,1401,1412,1430,1406,1438,1485,1524,1512,1499,1528,1496,1466,1408,1392,1430,1394,1369,1373,1408,1487,1466,1455,1493,1461,1429,1461,1496,1449,1476,1466,1447,1440,1473,1503,1581,1606,1587,1605,1584,1609,1688,1685,1694,1665,1732,1750,1802,1891,1926,1939,1951,1927,1902,1933,1938,1990,1996,1988,2008,2022,2049,2036,2017,2016,2032,2004,2015,2020,2070,2118,2144,2161,2117,2084,2056,1916,1797,1488,963,285) +smoothsp = smooth.spline(x,y,spar=0.35) +plot(smoothsp,type="l",col="blue",xlab="Percentile of Gene Body (5'->3')",ylab="Number of read",xlim=c(0,100)) +dev.state = dev.off() \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.mapq_profile.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,12 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.mapq_profile.png",width=500,height=500,units="px") +mapq_val=c(0,1,3,255) +mapq_count=c(573,3442,9322,64349) +xname=c("<3","<10","<20","<30","30-255") +freq = rep(0,5) +freq[1] = sum(mapq_count[which(mapq_val<3)])/77686*100 +freq[2] = sum(mapq_count[which(mapq_val<10)])/77686*100 +freq[3] = sum(mapq_count[which(mapq_val<20)])/77686*100 +freq[4] = sum(mapq_count[which(mapq_val<30)])/77686*100 +freq[5] = 100 +barplot(freq,beside=T,xlab="Mapping Quality",border="NA",space=1.5,main="Mapping Quality",ylim=c(0,100),ylab="Cumulative proportion (%)",col="blue",names.arg=xname) +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.mapq_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +MAPQ Read_Total Read_with_mapq +0 77686 573 +1 77686 3442 +3 77686 9322 +255 77686 64349
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.read_distr.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,6 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.read_distr.png",width=500,height=500,units="px") +M=c(24065,1500,15884,8486,169,452,8521,13287) +Mname=c("CDS","5UTR","3UTR","Intron","TSS_Up_1Kb","TES_Down_1Kb","rRNA","Others") +val = barplot(M,xlab="",space=1,ylab="Read Counts",col="blue",border="NA") +text(x=seq(val[1],val[8],by=2),y=rep(0,8),srt=60,adj=0,offset=2,pos=1,xpd=T,labels=Mname) +dev.state = dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.read_distr_pie.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.read_distr_pie.png",width=500,height=500,units="px") +pie(c(35107,508528),labels=c("Covered 35107 exons","Uncovered"),main="Exons",radius=0.6,clockwise=T,col=c("blue","white")) +dev.state = dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.readlen_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,35 @@ +Position Read_Total Read_Len_mapped +67 77686 220 +68 77686 212 +69 77686 287 +70 77686 315 +71 77686 327 +72 77686 323 +73 77686 420 +74 77686 437 +75 77686 447 +76 77686 422 +77 77686 435 +78 77686 429 +79 77686 427 +80 77686 487 +81 77686 438 +82 77686 487 +83 77686 492 +84 77686 492 +85 77686 518 +86 77686 536 +87 77686 517 +88 77686 565 +89 77686 503 +90 77686 550 +91 77686 723 +92 77686 808 +93 77686 803 +94 77686 859 +95 77686 881 +96 77686 927 +97 77686 945 +98 77686 1535 +99 77686 1897 +100 77686 44685
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp0.res.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,49 @@ +filename /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp0.res.txt +is_pairEnd 0 +clipping_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.clipping_profile.png +mapq_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.mapq_profile.png +mapq_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp0.mapq_profile.xls +read_cov_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.geneBodyCoverage.png +trans_cov_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.TransCoverage.png +insert_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.inner_distance_plot.png +insert_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp0.inner_distance_freq.txt +read_dist_plot_file1 /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.read_distr.png +read_dist_plot_file2 /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.read_distr_pie.png +readLen_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp0.readlen_profile.png +geneCount_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp0.geneAbundance.txt +seqDeDup_percent 0.000000 +posDeDup_percent 0.000000 +no_clipping 0 +no_rRNA 0 +total_reads 77686 +uniq_mapped_reads 64349 +multi_mapped_reads 13337 +unmapped_reads 0 +low_qual 0 +low_qual_read1 0 +low_qual_read2 0 +pcr_dup 0 +rRNA_read 8521 +cds_read 24065 +utr5_read 1500 +utr3_read 15884 +intron_read 8486 +itgup1k_read 169 +itgdn1k_read 452 +itg_read 13287 +unmapped_read1 0 +unmapped_read2 0 +mapped_read1 0 +mapped_read2 0 +forward_read 31875 +reverse_read 32474 +paired_reads 0 +mapped_plus_minus 0 +mapped_plus_plus 0 +mapped_minus_plus 0 +mapped_minus_minus 0 +ins_read 0 +del_read 0 +noSplice 50449 +splice 13900 +paired_diff_chrom 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.ReadLen_plot.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.readlen_profile.png",width=500,height=500,units="px") +readlen_val=c(67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100) +readlen_count=c(182,173,267,238,308,340,386,354,392,415,421,399,419,456,470,469,496,483,489,488,529,499,514,561,748,813,751,827,863,912,958,1648,1875,47529) +plot(readlen_val,(readlen_count/79258),pch=20,xlab="Mapped Read Length",ylab="Proportion",col="blue") +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.TransCoverage.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,10 @@ +png('/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.TransCoverage.png',width=500,height=500,units='px') 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+Fn = ecdf(a) +max_x = round(log(max(knots(Fn)),2),0) +xx = c(0,2^seq(0,max_x,by=2)) +y=Fn(xx) +xlog = log(xx[2:length(xx)],base=2) +plot(x=c(-1,xlog),y=y,xaxt = 'n',type="b",col="blue",pch=20,xlab="Number of Reads",ylab="Cumulative proportion of Genes") +axis(1,at = c(-1,seq(0,max_x,by=2)),labels=c(0,2^seq(0,max_x,by=2))) +dev.state = dev.off() \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.clipping_profile.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.clipping_profile.png",width=500,height=500,units="px") +read_pos=c(0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99) +count=c(10080,9066,8130,7621,7132,6639,6173,5746,5321,4915,4597,4335,4076,3809,3556,3301,3060,2829,2599,2347,2127,1921,1710,1505,1283,1093,918,736,568,415,305,164,84,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,85,162,278,386,526,692,871,1040,1222,1412,1610,1804,2008,2226,2447,2677,2949,3192,3438,3680,3952,4204,4467,4757,5154,5574,5983,6410,6874,7383,7905,8793,9768) +plot(read_pos,1-(count/79258),pch=20,xlab="Position of reads",ylab="Mappability",col="blue") +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.clipping_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,101 @@ +Position Read_Total Read_clipped +0 79258 10080 +1 79258 9066 +2 79258 8130 +3 79258 7621 +4 79258 7132 +5 79258 6639 +6 79258 6173 +7 79258 5746 +8 79258 5321 +9 79258 4915 +10 79258 4597 +11 79258 4335 +12 79258 4076 +13 79258 3809 +14 79258 3556 +15 79258 3301 +16 79258 3060 +17 79258 2829 +18 79258 2599 +19 79258 2347 +20 79258 2127 +21 79258 1921 +22 79258 1710 +23 79258 1505 +24 79258 1283 +25 79258 1093 +26 79258 918 +27 79258 736 +28 79258 568 +29 79258 415 +30 79258 305 +31 79258 164 +32 79258 84 +33 79258 0 +34 79258 0 +35 79258 0 +36 79258 0 +37 79258 0 +38 79258 0 +39 79258 0 +40 79258 0 +41 79258 0 +42 79258 0 +43 79258 0 +44 79258 0 +45 79258 0 +46 79258 0 +47 79258 0 +48 79258 0 +49 79258 0 +50 79258 0 +51 79258 0 +52 79258 0 +53 79258 0 +54 79258 0 +55 79258 0 +56 79258 0 +57 79258 0 +58 79258 0 +59 79258 0 +60 79258 0 +61 79258 0 +62 79258 0 +63 79258 0 +64 79258 0 +65 79258 0 +66 79258 0 +67 79258 85 +68 79258 162 +69 79258 278 +70 79258 386 +71 79258 526 +72 79258 692 +73 79258 871 +74 79258 1040 +75 79258 1222 +76 79258 1412 +77 79258 1610 +78 79258 1804 +79 79258 2008 +80 79258 2226 +81 79258 2447 +82 79258 2677 +83 79258 2949 +84 79258 3192 +85 79258 3438 +86 79258 3680 +87 79258 3952 +88 79258 4204 +89 79258 4467 +90 79258 4757 +91 79258 5154 +92 79258 5574 +93 79258 5983 +94 79258 6410 +95 79258 6874 +96 79258 7383 +97 79258 7905 +98 79258 8793 +99 79258 9768
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.geneAbundance.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,27321 @@ +gene Counts +AADACL3 0 +AADACL4 0 +ABCD3 1 +ACADM 0 +ACKR1 0 +ACOT11 0 +ACTG1P4 0 +ACTL8 243 +ACTN2 0 +ACTRT2 0 +ADAM15 0 +ADAMTSL4 0 +ADCK3 0 +ADORA1 0 +ADPRHL2 0 +AGL 0 +AGO1 2 +AGO3 0 +AGO4 0 +AGRN 0 +AGTRAP 0 +AHCYL1 1 +AJAP1 0 +AK4 1 +AK5 0 +AKIRIN1 2 +AKR1A1 1 +AKR7A2P1 0 +ALG6 1 +ALPL 0 +AMPD2 2 +AMY1A 0 +AMY1B 0 +AMY1C 0 +AMY2A 0 +AMY2B 0 +ANGPTL3 0 +ANGPTL7 0 +ANKRD34A 0 +ANKRD35 0 +ANXA9 0 +AP4B1-AS1 0 +APCS 0 +APITD1 5 +APITD1-CORT 6 +APOA1BP 0 +AQP10 0 +ARF1 27 +ARHGEF10L 0 +ARHGEF16 4 +ARID1A 20 +ARTN 0 +ARV1 0 +ASH1L-AS1 0 +ATAD3A 1 +ATAD3B 0 +ATAD3C 2 +ATF3 0 +ATF6 3 +ATG4C 1 +ATP1A1 21 +ATP1A2 0 +ATP1A4 0 +ATP1B1 16 +ATP2B4 18 +ATP5F1 2 +ATP6V0B 2 +ATP8B2 0 +ATPIF1 1 +ATXN7L2 1 +AVPR1B 0 +AXDND1 0 +AZIN2 0 +B3GALT6 1 +B4GALT2 0 +BCAN 0 +BCL9 1 +BECN1P1 0 +BGLAP 0 +BLZF1 1 +BMP8A 0 +BNIPL 0 +BOLA1 0 +BRDT 9 +BRINP2 0 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+PNCK 0 +PNMA5 0 +PNPLA4 2 +POF1B 0 +PPEF1-AS1 0 +PPP1R2P9 0 +PPP2R3B 0 +PRAF2 1 +PRICKLE3 0 +PRKX 0 +PSMD10 3 +PTCHD1-AS 0 +RAB39B 0 +RAB40A 0 +RAB9B 0 +RAI2 0 +RAP2C 0 +RBBP7 59 +RBM41 1 +RBMX 6 +RENBP 0 +RGAG4 0 +RHOXF1 0 +RHOXF2 0 +RHOXF2B 0 +RIPPLY1 0 +RLIM 3 +RNF113A 2 +RNU6-2 0 +RNU6-28P 0 +RP11-87M18.2 0 +RPGR 2 +RPL39 1 +RPS4X 10 +RPS6KA3 1 +RPS6KA6 0 +RS1 1 +SATL1 0 +SCARNA9L 0 +SCML2 3 +SEPT6 0 +SERPINA7 0 +SH3KBP1 17 +SHROOM4 0 +SLC10A3 2 +SLC25A5-AS1 0 +SLC25A53 0 +SLC25A6 0 +SLC35A2 1 +SLC38A5 0 +SLC7A3 0 +SLC9A7 0 +SLITRK4 0 +SMARCA1 0 +SMC1A 3 +SMEK3P 0 +SMIM9 0 +SMPX 0 +SNORA11D 0 +SNORA11E 0 +SNORA69 0 +SNORD61 0 +SNORD96B 0 +SNX12 2 +SOX3 0 +SPANXA1 0 +SPANXA2 0 +SPANXC 0 +SPANXD 0 +SPANXN2 0 +SPANXN3 0 +SPANXN5 0 +SPIN2A 0 +SPIN2B 0 +SPIN3 3 +SPIN4 0 +SRPX 0 +SSX2 0 +SSX2B 0 +SSX3 0 +SSX4 0 +SSX4B 0 +SSX5 0 +SSX7 0 +SSX9 0 +SUPT20HL2 2 +SYN1 0 +SYP 0 +SYTL4 4 +TAB3 2 +TAF7L 0 +TAF9B 0 +TCEAL5 0 +TCEAL6 0 +TCEAL8 0 +TCP11X2 0 +TENM1 0 +TEX11 0 +TEX13A 0 +TEX13B 0 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+RBMY1F 0 +RBMY1J 0 +RBMY2EP 0 +RBMY3AP 0 +SLC25A6 0 +SRY 0 +TTTY1 0 +TTTY10 0 +TTTY11 0 +TTTY13 0 +TTTY14 0 +TTTY16 0 +TTTY17A 0 +TTTY17B 0 +TTTY17C 0 +TTTY18 0 +TTTY1B 0 +TTTY2 0 +TTTY20 0 +TTTY21 0 +TTTY21B 0 +TTTY23 0 +TTTY23B 0 +TTTY2B 0 +TTTY3 0 +TTTY3B 0 +TTTY4 0 +TTTY4B 0 +TTTY4C 0 +TTTY5 0 +TTTY6 0 +TTTY6B 0 +TTTY7 0 +TTTY7B 0 +TTTY8 0 +TTTY8B 0 +TTTY9A 0 +TTTY9B 0 +UTY 0 +VCY 0 +VCY1B 0 +XKRY 0 +XKRY2 0 +ZBED1 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.geneBodyCoverage.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,104 @@ +Total reads: 79258 +Fragment number: 50503 +percentile count +0 200 +1 400 +2 561 +3 726 +4 832 +5 920 +6 1032 +7 1085 +8 1102 +9 1152 +10 1242 +11 1245 +12 1193 +13 1258 +14 1260 +15 1306 +16 1238 +17 1246 +18 1259 +19 1290 +20 1318 +21 1304 +22 1374 +23 1410 +24 1391 +25 1477 +26 1438 +27 1445 +28 1468 +29 1418 +30 1457 +31 1443 +32 1382 +33 1404 +34 1422 +35 1489 +36 1478 +37 1445 +38 1467 +39 1484 +40 1486 +41 1446 +42 1485 +43 1474 +44 1468 +45 1433 +46 1448 +47 1466 +48 1466 +49 1472 +50 1493 +51 1446 +52 1465 +53 1507 +54 1489 +55 1536 +56 1628 +57 1639 +58 1606 +59 1638 +60 1612 +61 1612 +62 1593 +63 1631 +64 1672 +65 1715 +66 1767 +67 1782 +68 1832 +69 1881 +70 1866 +71 1877 +72 1938 +73 1992 +74 1969 +75 1940 +76 1936 +77 1936 +78 1960 +79 1988 +80 1949 +81 1964 +82 1955 +83 1988 +84 1984 +85 2020 +86 2055 +87 2110 +88 2140 +89 2100 +90 2106 +91 2128 +92 2135 +93 2150 +94 2146 +95 2062 +96 1995 +97 1875 +98 1549 +99 982 +100 284
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.geneBodyCoverage_plot.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,6 @@ +png('/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.geneBodyCoverage.png',width=500,height=500,units='px') +x=c(0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100) +y=c(200,400,561,726,832,920,1032,1085,1102,1152,1242,1245,1193,1258,1260,1306,1238,1246,1259,1290,1318,1304,1374,1410,1391,1477,1438,1445,1468,1418,1457,1443,1382,1404,1422,1489,1478,1445,1467,1484,1486,1446,1485,1474,1468,1433,1448,1466,1466,1472,1493,1446,1465,1507,1489,1536,1628,1639,1606,1638,1612,1612,1593,1631,1672,1715,1767,1782,1832,1881,1866,1877,1938,1992,1969,1940,1936,1936,1960,1988,1949,1964,1955,1988,1984,2020,2055,2110,2140,2100,2106,2128,2135,2150,2146,2062,1995,1875,1549,982,284) +smoothsp = smooth.spline(x,y,spar=0.35) +plot(smoothsp,type="l",col="blue",xlab="Percentile of Gene Body (5'->3')",ylab="Number of read",xlim=c(0,100)) +dev.state = dev.off() \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.mapq_profile.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,12 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.mapq_profile.png",width=500,height=500,units="px") +mapq_val=c(0,1,3,255) +mapq_count=c(589,3042,8955,66672) +xname=c("<3","<10","<20","<30","30-255") +freq = rep(0,5) +freq[1] = sum(mapq_count[which(mapq_val<3)])/79258*100 +freq[2] = sum(mapq_count[which(mapq_val<10)])/79258*100 +freq[3] = sum(mapq_count[which(mapq_val<20)])/79258*100 +freq[4] = sum(mapq_count[which(mapq_val<30)])/79258*100 +freq[5] = 100 +barplot(freq,beside=T,xlab="Mapping Quality",border="NA",space=1.5,main="Mapping Quality",ylim=c(0,100),ylab="Cumulative proportion (%)",col="blue",names.arg=xname) +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.mapq_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +MAPQ Read_Total Read_with_mapq +0 79258 589 +1 79258 3042 +3 79258 8955 +255 79258 66672
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.read_distr.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,6 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.read_distr.png",width=500,height=500,units="px") +M=c(24849,1533,16115,8729,205,453,7563,14335) +Mname=c("CDS","5UTR","3UTR","Intron","TSS_Up_1Kb","TES_Down_1Kb","rRNA","Others") +val = barplot(M,xlab="",space=1,ylab="Read Counts",col="blue",border="NA") +text(x=seq(val[1],val[8],by=2),y=rep(0,8),srt=60,adj=0,offset=2,pos=1,xpd=T,labels=Mname) +dev.state = dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.read_distr_pie.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.read_distr_pie.png",width=500,height=500,units="px") +pie(c(35430,508205),labels=c("Covered 35430 exons","Uncovered"),main="Exons",radius=0.6,clockwise=T,col=c("blue","white")) +dev.state = dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.readlen_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,35 @@ +Position Read_Total Read_Len_mapped +67 79258 182 +68 79258 173 +69 79258 267 +70 79258 238 +71 79258 308 +72 79258 340 +73 79258 386 +74 79258 354 +75 79258 392 +76 79258 415 +77 79258 421 +78 79258 399 +79 79258 419 +80 79258 456 +81 79258 470 +82 79258 469 +83 79258 496 +84 79258 483 +85 79258 489 +86 79258 488 +87 79258 529 +88 79258 499 +89 79258 514 +90 79258 561 +91 79258 748 +92 79258 813 +93 79258 751 +94 79258 827 +95 79258 863 +96 79258 912 +97 79258 958 +98 79258 1648 +99 79258 1875 +100 79258 47529
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp1.res.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,49 @@ +filename /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp1.res.txt +is_pairEnd 0 +clipping_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.clipping_profile.png +mapq_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.mapq_profile.png +mapq_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp1.mapq_profile.xls +read_cov_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.geneBodyCoverage.png +trans_cov_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.TransCoverage.png +insert_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.inner_distance_plot.png +insert_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp1.inner_distance_freq.txt +read_dist_plot_file1 /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.read_distr.png +read_dist_plot_file2 /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.read_distr_pie.png +readLen_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp1.readlen_profile.png +geneCount_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp1.geneAbundance.txt +seqDeDup_percent 0.000000 +posDeDup_percent 0.000000 +no_clipping 0 +no_rRNA 0 +total_reads 79258 +uniq_mapped_reads 66672 +multi_mapped_reads 12586 +unmapped_reads 0 +low_qual 0 +low_qual_read1 0 +low_qual_read2 0 +pcr_dup 0 +rRNA_read 7563 +cds_read 24849 +utr5_read 1533 +utr3_read 16115 +intron_read 8729 +itgup1k_read 205 +itgdn1k_read 453 +itg_read 14335 +unmapped_read1 0 +unmapped_read2 0 +mapped_read1 0 +mapped_read2 0 +forward_read 33207 +reverse_read 33465 +paired_reads 0 +mapped_plus_minus 0 +mapped_plus_plus 0 +mapped_minus_plus 0 +mapped_minus_minus 0 +ins_read 0 +del_read 0 +noSplice 52213 +splice 14459 +paired_diff_chrom 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.ReadLen_plot.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.readlen_profile.png",width=500,height=500,units="px") +readlen_val=c(67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100) +readlen_count=c(182,177,265,292,322,337,407,384,377,408,421,433,465,412,463,458,469,448,457,476,520,507,519,576,723,741,800,824,805,847,931,1476,1885,50582) +plot(readlen_val,(readlen_count/80603),pch=20,xlab="Mapped Read Length",ylab="Proportion",col="blue") +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.TransCoverage.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,10 @@ +png('/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.TransCoverage.png',width=500,height=500,units='px') 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+Fn = ecdf(a) +max_x = round(log(max(knots(Fn)),2),0) +xx = c(0,2^seq(0,max_x,by=2)) +y=Fn(xx) +xlog = log(xx[2:length(xx)],base=2) +plot(x=c(-1,xlog),y=y,xaxt = 'n',type="b",col="blue",pch=20,xlab="Number of Reads",ylab="Cumulative proportion of Genes") +axis(1,at = c(-1,seq(0,max_x,by=2)),labels=c(0,2^seq(0,max_x,by=2))) +dev.state = dev.off() \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.clipping_profile.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.clipping_profile.png",width=500,height=500,units="px") +read_pos=c(0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99) +count=c(9897,8881,8055,7532,7071,6644,6233,5790,5380,4983,4673,4419,4164,3892,3642,3403,3180,2938,2701,2456,2234,2000,1788,1577,1358,1179,998,799,620,447,306,184,92,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,77,152,275,404,546,700,889,1068,1241,1434,1632,1854,2085,2269,2480,2702,2931,3160,3397,3636,3894,4147,4415,4708,5084,5476,5908,6362,6820,7294,7783,8595,9576) +plot(read_pos,1-(count/80603),pch=20,xlab="Position of reads",ylab="Mappability",col="blue") +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.clipping_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,101 @@ +Position Read_Total Read_clipped +0 80603 9897 +1 80603 8881 +2 80603 8055 +3 80603 7532 +4 80603 7071 +5 80603 6644 +6 80603 6233 +7 80603 5790 +8 80603 5380 +9 80603 4983 +10 80603 4673 +11 80603 4419 +12 80603 4164 +13 80603 3892 +14 80603 3642 +15 80603 3403 +16 80603 3180 +17 80603 2938 +18 80603 2701 +19 80603 2456 +20 80603 2234 +21 80603 2000 +22 80603 1788 +23 80603 1577 +24 80603 1358 +25 80603 1179 +26 80603 998 +27 80603 799 +28 80603 620 +29 80603 447 +30 80603 306 +31 80603 184 +32 80603 92 +33 80603 0 +34 80603 0 +35 80603 0 +36 80603 0 +37 80603 0 +38 80603 0 +39 80603 0 +40 80603 0 +41 80603 0 +42 80603 0 +43 80603 0 +44 80603 0 +45 80603 0 +46 80603 0 +47 80603 0 +48 80603 0 +49 80603 0 +50 80603 0 +51 80603 0 +52 80603 0 +53 80603 0 +54 80603 0 +55 80603 0 +56 80603 0 +57 80603 0 +58 80603 0 +59 80603 0 +60 80603 0 +61 80603 0 +62 80603 0 +63 80603 0 +64 80603 0 +65 80603 0 +66 80603 0 +67 80603 77 +68 80603 152 +69 80603 275 +70 80603 404 +71 80603 546 +72 80603 700 +73 80603 889 +74 80603 1068 +75 80603 1241 +76 80603 1434 +77 80603 1632 +78 80603 1854 +79 80603 2085 +80 80603 2269 +81 80603 2480 +82 80603 2702 +83 80603 2931 +84 80603 3160 +85 80603 3397 +86 80603 3636 +87 80603 3894 +88 80603 4147 +89 80603 4415 +90 80603 4708 +91 80603 5084 +92 80603 5476 +93 80603 5908 +94 80603 6362 +95 80603 6820 +96 80603 7294 +97 80603 7783 +98 80603 8595 +99 80603 9576
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.geneAbundance.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,27321 @@ +gene Counts +AADACL3 0 +AADACL4 0 +ABCD3 4 +ACADM 0 +ACKR1 0 +ACOT11 0 +ACTG1P4 0 +ACTL8 166 +ACTN2 0 +ACTRT2 0 +ADAM15 0 +ADAMTSL4 0 +ADCK3 0 +ADORA1 0 +ADPRHL2 0 +AGL 0 +AGO1 3 +AGO3 0 +AGO4 0 +AGRN 0 +AGTRAP 1 +AHCYL1 1 +AJAP1 0 +AK4 2 +AK5 0 +AKIRIN1 2 +AKR1A1 0 +AKR7A2P1 0 +ALG6 0 +ALPL 0 +AMPD2 1 +AMY1A 0 +AMY1B 0 +AMY1C 0 +AMY2A 0 +AMY2B 0 +ANGPTL3 0 +ANGPTL7 0 +ANKRD34A 0 +ANKRD35 0 +ANXA9 0 +AP4B1-AS1 0 +APCS 0 +APITD1 6 +APITD1-CORT 2 +APOA1BP 0 +AQP10 0 +ARF1 31 +ARHGEF10L 0 +ARHGEF16 1 +ARID1A 9 +ARTN 0 +ARV1 0 +ASH1L-AS1 0 +ATAD3A 0 +ATAD3B 0 +ATAD3C 1 +ATF3 0 +ATF6 3 +ATG4C 1 +ATP1A1 14 +ATP1A2 0 +ATP1A4 0 +ATP1B1 10 +ATP2B4 10 +ATP5F1 2 +ATP6V0B 2 +ATP8B2 0 +ATPIF1 0 +ATXN7L2 0 +AVPR1B 0 +AXDND1 0 +AZIN2 1 +B3GALT6 0 +B4GALT2 0 +BCAN 0 +BCL9 4 +BECN1P1 0 +BGLAP 0 +BLZF1 0 +BMP8A 0 +BNIPL 0 +BOLA1 0 +BRDT 6 +BRINP2 0 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+RBMY1J 0 +RBMY2EP 0 +RBMY3AP 0 +SLC25A6 0 +SRY 0 +TTTY1 0 +TTTY10 0 +TTTY11 0 +TTTY13 0 +TTTY14 0 +TTTY16 0 +TTTY17A 0 +TTTY17B 0 +TTTY17C 0 +TTTY18 0 +TTTY1B 0 +TTTY2 0 +TTTY20 0 +TTTY21 0 +TTTY21B 0 +TTTY23 0 +TTTY23B 0 +TTTY2B 0 +TTTY3 0 +TTTY3B 0 +TTTY4 0 +TTTY4B 0 +TTTY4C 0 +TTTY5 0 +TTTY6 0 +TTTY6B 0 +TTTY7 0 +TTTY7B 0 +TTTY8 0 +TTTY8B 0 +TTTY9A 0 +TTTY9B 0 +UTY 0 +VCY 0 +VCY1B 0 +XKRY 0 +XKRY2 0 +ZBED1 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.geneBodyCoverage.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,104 @@ +Total reads: 80603 +Fragment number: 45981 +percentile count +0 172 +1 322 +2 489 +3 620 +4 693 +5 723 +6 766 +7 838 +8 861 +9 939 +10 1020 +11 1028 +12 988 +13 1055 +14 1122 +15 1087 +16 1031 +17 1082 +18 1111 +19 1119 +20 1184 +21 1144 +22 1167 +23 1176 +24 1145 +25 1143 +26 1129 +27 1185 +28 1192 +29 1207 +30 1225 +31 1185 +32 1213 +33 1241 +34 1268 +35 1313 +36 1240 +37 1204 +38 1190 +39 1235 +40 1269 +41 1295 +42 1328 +43 1308 +44 1229 +45 1220 +46 1252 +47 1273 +48 1272 +49 1295 +50 1283 +51 1335 +52 1335 +53 1334 +54 1377 +55 1385 +56 1434 +57 1411 +58 1407 +59 1424 +60 1420 +61 1450 +62 1458 +63 1483 +64 1511 +65 1560 +66 1583 +67 1627 +68 1669 +69 1710 +70 1777 +71 1792 +72 1812 +73 1825 +74 1802 +75 1862 +76 1857 +77 1900 +78 1880 +79 1874 +80 1867 +81 1859 +82 1869 +83 1859 +84 1851 +85 1897 +86 1883 +87 1971 +88 2030 +89 1992 +90 1971 +91 2017 +92 2030 +93 1983 +94 1995 +95 1959 +96 1896 +97 1787 +98 1461 +99 980 +100 288
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.geneBodyCoverage_plot.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,6 @@ +png('/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.geneBodyCoverage.png',width=500,height=500,units='px') +x=c(0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100) +y=c(172,322,489,620,693,723,766,838,861,939,1020,1028,988,1055,1122,1087,1031,1082,1111,1119,1184,1144,1167,1176,1145,1143,1129,1185,1192,1207,1225,1185,1213,1241,1268,1313,1240,1204,1190,1235,1269,1295,1328,1308,1229,1220,1252,1273,1272,1295,1283,1335,1335,1334,1377,1385,1434,1411,1407,1424,1420,1450,1458,1483,1511,1560,1583,1627,1669,1710,1777,1792,1812,1825,1802,1862,1857,1900,1880,1874,1867,1859,1869,1859,1851,1897,1883,1971,2030,1992,1971,2017,2030,1983,1995,1959,1896,1787,1461,980,288) +smoothsp = smooth.spline(x,y,spar=0.35) +plot(smoothsp,type="l",col="blue",xlab="Percentile of Gene Body (5'->3')",ylab="Number of read",xlim=c(0,100)) +dev.state = dev.off() \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.mapq_profile.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,12 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.mapq_profile.png",width=500,height=500,units="px") +mapq_val=c(0,1,3,255) +mapq_count=c(525,2546,8143,69389) +xname=c("<3","<10","<20","<30","30-255") +freq = rep(0,5) +freq[1] = sum(mapq_count[which(mapq_val<3)])/80603*100 +freq[2] = sum(mapq_count[which(mapq_val<10)])/80603*100 +freq[3] = sum(mapq_count[which(mapq_val<20)])/80603*100 +freq[4] = sum(mapq_count[which(mapq_val<30)])/80603*100 +freq[5] = 100 +barplot(freq,beside=T,xlab="Mapping Quality",border="NA",space=1.5,main="Mapping Quality",ylim=c(0,100),ylab="Cumulative proportion (%)",col="blue",names.arg=xname) +dev.state=dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.mapq_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,5 @@ +MAPQ Read_Total Read_with_mapq +0 80603 525 +1 80603 2546 +3 80603 8143 +255 80603 69389
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.read_distr.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,6 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.read_distr.png",width=500,height=500,units="px") +M=c(22143,1293,15499,7798,156,511,5939,21398) +Mname=c("CDS","5UTR","3UTR","Intron","TSS_Up_1Kb","TES_Down_1Kb","rRNA","Others") +val = barplot(M,xlab="",space=1,ylab="Read Counts",col="blue",border="NA") +text(x=seq(val[1],val[8],by=2),y=rep(0,8),srt=60,adj=0,offset=2,pos=1,xpd=T,labels=Mname) +dev.state = dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.read_distr_pie.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,3 @@ +png("/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.read_distr_pie.png",width=500,height=500,units="px") +pie(c(32831,510804),labels=c("Covered 32831 exons","Uncovered"),main="Exons",radius=0.6,clockwise=T,col=c("blue","white")) +dev.state = dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.readlen_profile.xls Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,35 @@ +Position Read_Total Read_Len_mapped +67 80603 182 +68 80603 177 +69 80603 265 +70 80603 292 +71 80603 322 +72 80603 337 +73 80603 407 +74 80603 384 +75 80603 377 +76 80603 408 +77 80603 421 +78 80603 433 +79 80603 465 +80 80603 412 +81 80603 463 +82 80603 458 +83 80603 469 +84 80603 448 +85 80603 457 +86 80603 476 +87 80603 520 +88 80603 507 +89 80603 519 +90 80603 576 +91 80603 723 +92 80603 741 +93 80603 800 +94 80603 824 +95 80603 805 +96 80603 847 +97 80603 931 +98 80603 1476 +99 80603 1885 +100 80603 50582
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp2.res.txt Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,49 @@ +filename /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp2.res.txt +is_pairEnd 0 +clipping_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.clipping_profile.png +mapq_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.mapq_profile.png +mapq_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp2.mapq_profile.xls +read_cov_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.geneBodyCoverage.png +trans_cov_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.TransCoverage.png +insert_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.inner_distance_plot.png +insert_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp2.inner_distance_freq.txt +read_dist_plot_file1 /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.read_distr.png +read_dist_plot_file2 /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.read_distr_pie.png +readLen_plot_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp2.readlen_profile.png +geneCount_file /sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/data/smp2.geneAbundance.txt +seqDeDup_percent 0.000000 +posDeDup_percent 0.000000 +no_clipping 0 +no_rRNA 0 +total_reads 80603 +uniq_mapped_reads 69389 +multi_mapped_reads 11214 +unmapped_reads 0 +low_qual 0 +low_qual_read1 0 +low_qual_read2 0 +pcr_dup 0 +rRNA_read 5939 +cds_read 22143 +utr5_read 1293 +utr3_read 15499 +intron_read 7798 +itgup1k_read 156 +itgdn1k_read 511 +itg_read 21398 +unmapped_read1 0 +unmapped_read2 0 +mapped_read1 0 +mapped_read2 0 +forward_read 34065 +reverse_read 35324 +paired_reads 0 +mapped_plus_minus 0 +mapped_plus_plus 0 +mapped_minus_plus 0 +mapped_minus_minus 0 +ins_read 0 +del_read 0 +noSplice 56765 +splice 12624 +paired_diff_chrom 0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/data/smp_correlation.r Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,78 @@ +library(corrplot) +srcfiles = c("test1/data/smp0.geneAbundance.txt","test1/data/smp1.geneAbundance.txt","test1/data/smp2.geneAbundance.txt") +destfile = "/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp_corr.png" +f1 = read.delim(srcfiles[1],header=T) +MM=matrix(nrow=length(f1[,1]),ncol=length(srcfiles)) +rownames(MM)=f1[,1] +MM[,1]=f1[,2] +for (i in 2:length(srcfiles)){ + f = read.delim(srcfiles[i],header=T) + MM[,i] = f[,2] } +colnames(MM)=c("smp0","smp1","smp2") +libSize<-colSums(MM) +MM<-t(t(MM)*1000000/libSize) +ss<-rowSums(MM) +M1<-MM[ss>0,] +MM_s<-t(scale(t(M1))) +M.cor<-cor(MM_s,method='sp') +M.cor[is.na(M.cor)]<- 0 +png(destfile,width=500,height=500,units='px') +corrplot(M.cor,is.corr=T,order='FPC',method='color',type='full',add=F,diag=T) +dev.state = dev.off() +nz_genes = length(M1[,1]) +destfile = "/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp_reproducibility.png" +if(nz_genes >0) { +png(destfile,width=500,height=500,units='px') +nz_gene_mm = rep(0,length(M1[1,])) +for(i in 1:length(M1[1,])) { +nz_gene_mm[i] = length(which(M1[,i]>0))/nz_genes * 100 } +bplt <- barplot(nz_gene_mm,beside=T,border='NA',space=1.5,ylim=c(0,100),ylab='Genes reproducibly detected (%)',col='blue',names.arg=colnames(MM)) +text(y= nz_gene_mm+2, x= bplt, labels=paste(as.character(round(nz_gene_mm,digits=1)),'%',sep=''), xpd=TRUE) +dev.state = dev.off()} +destfile = "/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp_var.png" +png(destfile,width=500,height=500,units='px') +mad = rep(0,length(M1[,1])) +nz_gene_median = rep(0,length(M1[,1])) +for(i in 1:length(M1[,1])) { +nz_gene_median[i] = median(M1[i,]) +mad[i] = median(abs(M1[i,]-nz_gene_median[i])) } +mad2 = mad[nz_gene_median >0] +nz_gene_median2 = nz_gene_median[nz_gene_median>0] +mad_vs_median = mad2/nz_gene_median2 +nz_gene_median3 = log(nz_gene_median2, base=2) +dd<-data.frame(nz_gene_median3,mad_vs_median) +x = densCols(nz_gene_median3,mad_vs_median, colramp=colorRampPalette(c('black', 'white'))) +dd$dens <- col2rgb(x)[1,] + 1L +cols <- colorRampPalette(c("#000099", "#00FEFF", "#45FE4F", "#FCFF00", "#FF9400", "#FF3100"))(256) +dd$col <- cols[dd$dens] +plot(mad_vs_median ~ nz_gene_median3,data=dd[order(dd$dens),], col=col, pch=20,xlab="Gene expression (median RPM log2)",ylab="Median absolute deviation/median") +dev.state = dev.off() +destfile = "/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp_cov.png" +png(destfile,width=500,height=500,units='px') +xname=c("<0.5","0.5-10","10-100",">=100") +Fn_mm = matrix(0,nrow=length(xname),ncol=length(M1[1,])) +rownames(Fn_mm) = xname +colnames(Fn_mm) = c("smp0","smp1","smp2") +for(i in 1:length(M1[1,])) { +Fn_mm[1,i] = length(which(M1[,i]<0.5)) +Fn_mm[2,i] = length(which(M1[,i]>=0.5 & M1[,i]<10)) +Fn_mm[3,i] = length(which(M1[,i]>=10 & M1[,i]<100)) +Fn_mm[4,i] = length(which(M1[,i]>=100)) } +barplot(Fn_mm,main="Gene abundance (RPM)",xlab="Sample",ylab="Frequency",col=c("green","blue","red","yellow"),legend=xname) +dev.state = dev.off() +destfile3 = "/sonas-hs/bsr/hpc/data/yjin/test_BAMqc/exp/test1/figs/smp_qual.png" +srcfiles3 = c("test1/data/smp0.mapq_profile.xls","test1/data/smp1.mapq_profile.xls","test1/data/smp2.mapq_profile.xls") +png(destfile3,width=500,height=500,units='px') +xname=c("<3","3-10","10-20","20-30",">=30") +Fn_mm = matrix(0,nrow=length(xname),ncol=length(srcfiles3)) +rownames(Fn_mm) = xname +colnames(Fn_mm) = c("smp0","smp1","smp2") +for(i in 1:length(srcfiles3)) { + f = read.delim(srcfiles3[i],header=T) + if(length(which(f[,1]<3)) >0){ Fn_mm[1,i] = sum(f[which(f[,1]<3),3])/f[1,2]} +if(length(which(f[,1]>=3 & f[,1]<10)) >0) {Fn_mm[2,i] = sum(f[which(f[,1]<10 & f[,1]>=3),3])/f[1,2]} +if(length(which(f[,1]>=10 & f[,1]<20)) >0) {Fn_mm[3,i] = sum(f[which(f[,1]<20 & f[,1]>=10),3])/f[1,2] } +if(length(which(f[,1]>=20 & f[,1]<30)) >0) {Fn_mm[4,i] = sum(f[which(f[,1]<30 & f[,1]>=20),3])/f[1,2]} +if(length(which(f[,1]>=30)) >0) {Fn_mm[5,i] = sum(f[which(f[,1]>=30),3])/f[1,2] }} +barplot(Fn_mm,xlab="Sample",main="Mapping Quality",ylim=c(0,1),ylab="Frequency",col=c("blue","green","yellow","orange","red"),legend=xname) +dev.state = dev.off()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/ezBAMQC/test-data/output/ezBAMQC_output.html Thu Mar 24 17:12:52 2016 -0400 @@ -0,0 +1,144 @@ +<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Strict//EN"> +<html> +<head><title>ezBAMQC Report</title> +<style type="text/css"> +html,body{margin:0;padding:0;height:100%;width:1500px} +div#header{background-color:#F3F2ED;} +div#header h1{text-align:center; height:80px;line-height:80px;margin:0;padding-left:10px;} +div#container{text-align:left;height:100%;width:1500px} +div#navigation{background:#F6F0E0;} +div#navigation{float:left;width:200px;height:100%} +.menu-item ul { +background: #F6F0E0; +font-size: 13px; +line-height: 30px; +height: 0px; +list-style-type: none;overflow: hidden; +padding: 0px; } +.menu-item:hover ul { height: 220px; } + table{ margin:0;padding:0;width:1300px;table-layout:fixed;text-align:left; } +table > thead > tr.tableizer-firstrow > th { padding: 10px; background: lavenderblush;} +table > tbody > tr > td{ padding: 10px; background: #f8f8f8; word-wrap: break word; } +div#footer{background:#BFBD93;} +div#footer p{margin:0;padding:5px 10px} +div#footer{clear:both;width:100%;text-align:center} +div#main{float:right;width:1300px} +a{text-decoration:none; color:#000000;} +a:hover {text-decoration: underline; } +</style> </head> +<body> +<div id ="container"> +<div id="header"><h1>ezBAMQC Report</h1><p text-align="left">Created On: 03-24-2016</p></div> +<div id="wrapper"> +<div class="summary" id="navigation"> +<h2>Summary</h2> +<ul> +<li><div class="menu-item"> +<h4>smp0</h4> +<ul> +<li><a href="#M00">Basic Statistics</a></li> +<li><a href="#M01">Read Distribution</a></li> +<li><a href="#M02">Mappability</a></li> +<li><a href="#M03">Coverage</a></li> +<li><a href="#M04">Read Length and Insertion Size</a></li> +</ul></div></li> +<li><div class="menu-item"> +<h4>smp1</h4> +<ul> +<li><a href="#M10">Basic Statistics</a></li> +<li><a href="#M11">Read Distribution</a></li> +<li><a href="#M12">Mappability</a></li> +<li><a href="#M13">Coverage</a></li> +<li><a href="#M14">Read Length and Insertion Size</a></li> +</ul></div></li> +<li><div class="menu-item"> +<h4>smp2</h4> +<ul> +<li><a href="#M20">Basic Statistics</a></li> +<li><a href="#M21">Read Distribution</a></li> +<li><a href="#M22">Mappability</a></li> +<li><a href="#M23">Coverage</a></li> +<li><a href="#M24">Read Length and Insertion Size</a></li> +</ul></div></li> +<li><div class="menu-item"><a href="#M115"><h4>Sample Correlation</h4></a></div></li> +</ul> +</div> +<div id="main" > +<h2>smp0</h2> +<div class="module"><h2 id="M00">Basic Statistics</h2> +<table> +<thead><tr class="tableizer-firstrow"> +<th>Measure</th><th>Value</th></tr></thead> +<tbody><tr><td>Total Reads</td><td>77686</td></tr> +<tr><td>Unique Reads</td><td>64349</td></tr> +<tr><td>Multi-reads</td><td>13337</td></tr> +<tr><td>Unmapped Reads</td><td>0</td></tr> +<tr><td>Low Quality Reads</td><td>0</td></tr> +<tr><td>Forward Reads</td><td>31875</td></tr> +<tr><td>Reverse Reads</td><td>32474</td></tr> +<tr><td>Splice Reads</td><td>13900</td></tr> +<tr><td>Non-Splice Reads</td><td>50449</td></tr> +<tr><td>rRNA Reads</td><td>8521</td></tr></tbody></table></div> +<div class="module"><h2 id="M01">Read Distribution</h2> +<p><img class="indented" src="./figs/smp0.read_distr.png" alt="Read Distribution"><img class="indented" src="./figs/smp0.read_distr_pie.png" alt="Read Distribution"></p></div> +<div class="module"><h2 id="M02">Mappability</h2> +<p><img class="indented" src="./figs/smp0.clipping_profile.png" alt="Mappablity Profile"> <img class="indented" src="./figs/smp0.mapq_profile.png" alt="MapQ Profile"></p></div> +<div class="module"><h2 id="M03">Coverage</h2> +<p><img class="indented" src="./figs/smp0.geneBodyCoverage.png" alt="Read Coverage"> <img class="indented" src="./figs/smp0.TransCoverage.png" alt="Read Coverage"></p></div> +<div class="module"><h2 id="M04">Read Length</h2> +<p><img class="indented" src="./figs/smp0.readlen_profile.png" alt="Read Length"></p></div> +<h2>smp1</h2> +<div class="module"><h2 id="M10">Basic Statistics</h2> +<table> +<thead><tr class="tableizer-firstrow"> +<th>Measure</th><th>Value</th></tr></thead> +<tbody><tr><td>Total Reads</td><td>79258</td></tr> +<tr><td>Unique Reads</td><td>66672</td></tr> +<tr><td>Multi-reads</td><td>12586</td></tr> +<tr><td>Unmapped Reads</td><td>0</td></tr> +<tr><td>Low Quality Reads</td><td>0</td></tr> +<tr><td>Forward Reads</td><td>33207</td></tr> +<tr><td>Reverse Reads</td><td>33465</td></tr> +<tr><td>Splice Reads</td><td>14459</td></tr> +<tr><td>Non-Splice Reads</td><td>52213</td></tr> +<tr><td>rRNA Reads</td><td>7563</td></tr></tbody></table></div> +<div class="module"><h2 id="M11">Read Distribution</h2> +<p><img class="indented" src="./figs/smp1.read_distr.png" alt="Read Distribution"><img class="indented" src="./figs/smp1.read_distr_pie.png" alt="Read Distribution"></p></div> +<div class="module"><h2 id="M12">Mappability</h2> +<p><img class="indented" src="./figs/smp1.clipping_profile.png" alt="Mappablity Profile"> <img class="indented" src="./figs/smp1.mapq_profile.png" alt="MapQ Profile"></p></div> +<div class="module"><h2 id="M13">Coverage</h2> +<p><img class="indented" src="./figs/smp1.geneBodyCoverage.png" alt="Read Coverage"> <img class="indented" src="./figs/smp1.TransCoverage.png" alt="Read Coverage"></p></div> +<div class="module"><h2 id="M14">Read Length</h2> +<p><img class="indented" src="./figs/smp1.readlen_profile.png" alt="Read Length"></p></div> +<h2>smp2</h2> +<div class="module"><h2 id="M20">Basic Statistics</h2> +<table> +<thead><tr class="tableizer-firstrow"> +<th>Measure</th><th>Value</th></tr></thead> +<tbody><tr><td>Total Reads</td><td>80603</td></tr> +<tr><td>Unique Reads</td><td>69389</td></tr> +<tr><td>Multi-reads</td><td>11214</td></tr> +<tr><td>Unmapped Reads</td><td>0</td></tr> +<tr><td>Low Quality Reads</td><td>0</td></tr> +<tr><td>Forward Reads</td><td>34065</td></tr> +<tr><td>Reverse Reads</td><td>35324</td></tr> +<tr><td>Splice Reads</td><td>12624</td></tr> +<tr><td>Non-Splice Reads</td><td>56765</td></tr> +<tr><td>rRNA Reads</td><td>5939</td></tr></tbody></table></div> +<div class="module"><h2 id="M21">Read Distribution</h2> +<p><img class="indented" src="./figs/smp2.read_distr.png" alt="Read Distribution"><img class="indented" src="./figs/smp2.read_distr_pie.png" alt="Read Distribution"></p></div> +<div class="module"><h2 id="M22">Mappability</h2> +<p><img class="indented" src="./figs/smp2.clipping_profile.png" alt="Mappablity Profile"> <img class="indented" src="./figs/smp2.mapq_profile.png" alt="MapQ Profile"></p></div> +<div class="module"><h2 id="M23">Coverage</h2> +<p><img class="indented" src="./figs/smp2.geneBodyCoverage.png" alt="Read Coverage"> <img class="indented" src="./figs/smp2.TransCoverage.png" alt="Read Coverage"></p></div> +<div class="module"><h2 id="M24">Read Length</h2> +<p><img class="indented" src="./figs/smp2.readlen_profile.png" alt="Read Length"></p></div> +<div class="Smp_corr"><h2 id="M115">Sample Correlation and Quality</h2> +<p><img class="indented" src="./figs/smp_corr.png" alt="Sample Correlation"><img class="indented" src="./figs/smp_qual.png" alt="Sample Correlation"></p> +<h2 id="M115">Sample Coverage</h2> +<p><img class="indented" src="./figs/smp_cov.png" alt="Sample Coverage"></p></div> +<h2 id="M115">Sample Variation</h2> +<p><img class="indented" src="./figs/smp_reproducibility.png" alt="Sample Variation"><img class="indented" src="./figs/smp_var.png" alt="Sample Variation"></p></div> +</div> +<div id="footer"><p>Produced by Bioinformatics Shared Resource at CSHL </p></div></div></div></body></html> +