comparison SMART/Java/Python/structure/Mapping.py @ 6:769e306b7933

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author yufei-luo
date Fri, 18 Jan 2013 04:54:14 -0500
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5:ea3082881bf8 6:769e306b7933
1 #
2 # Copyright INRA-URGI 2009-2010
3 #
4 # This software is governed by the CeCILL license under French law and
5 # abiding by the rules of distribution of free software. You can use,
6 # modify and/ or redistribute the software under the terms of the CeCILL
7 # license as circulated by CEA, CNRS and INRIA at the following URL
8 # "http://www.cecill.info".
9 #
10 # As a counterpart to the access to the source code and rights to copy,
11 # modify and redistribute granted by the license, users are provided only
12 # with a limited warranty and the software's author, the holder of the
13 # economic rights, and the successive licensors have only limited
14 # liability.
15 #
16 # In this respect, the user's attention is drawn to the risks associated
17 # with loading, using, modifying and/or developing or reproducing the
18 # software by the user in light of its specific status of free software,
19 # that may mean that it is complicated to manipulate, and that also
20 # therefore means that it is reserved for developers and experienced
21 # professionals having in-depth computer knowledge. Users are therefore
22 # encouraged to load and test the software's suitability as regards their
23 # requirements in conditions enabling the security of their systems and/or
24 # data to be ensured and, more generally, to use and operate it in the
25 # same conditions as regards security.
26 #
27 # The fact that you are presently reading this means that you have had
28 # knowledge of the CeCILL license and that you accept its terms.
29 #
30 from SMART.Java.Python.structure.SubMapping import SubMapping
31 from SMART.Java.Python.structure.Transcript import Transcript
32 from SMART.Java.Python.structure.Interval import Interval
33
34 class Mapping(object):
35 """A class that represents a mapping"""
36
37 def __init__(self):
38 self.targetInterval = None
39 self.queryInterval = None
40 self.subMappings = []
41 self.size = None
42 self.transcript = None
43 self.tags = {}
44
45
46 def copy(self, mapping):
47 for subMapping in mapping.subMappings:
48 newSubMapping = SubMapping(subMapping)
49 self.addSubMapping(newSubMapping)
50 self.targetInterval = Interval(mapping.targetInterval)
51 self.queryInterval = Interval(mapping.queryInterval)
52 self.size = mapping.size
53 self.tags = {}
54 for tag in mapping.tags:
55 self.tags[tag] = mapping[tag]
56 self.transcript.copy(mapping.transcript)
57
58
59 def setTargetInterval(self, interval):
60 self.targetInterval = Interval(interval)
61 if self.queryInterval != None:
62 self.setDirection(self.targetInterval.getDirection() * self.queryInterval.getDirection())
63
64
65 def setQueryInterval(self, interval):
66 self.queryInterval = Interval(interval)
67 if self.targetInterval != None:
68 self.setDirection(self.targetInterval.getDirection() * self.queryInterval.getDirection())
69
70
71 def getQueryInterval(self):
72 return self.queryInterval
73
74
75 def addSubMapping(self, subMapping):
76 subMappingCopy = SubMapping(subMapping)
77 self.subMappings.append(subMappingCopy)
78
79 if self.targetInterval:
80 self.targetInterval.setStart(min(self.targetInterval.getStart(), subMapping.targetInterval.getStart()))
81 self.targetInterval.setEnd(max(self.targetInterval.getEnd(), subMapping.targetInterval.getEnd()))
82 else:
83 self.setTargetInterval(subMapping.targetInterval)
84 if self.queryInterval:
85 self.queryInterval.setStart(min(self.queryInterval.getStart(), subMapping.queryInterval.getStart()))
86 self.queryInterval.setEnd(max(self.queryInterval.getEnd(), subMapping.queryInterval.getEnd()))
87 else:
88 self.setQueryInterval(subMapping.queryInterval)
89
90 if self.getDirection() != 0:
91 subMapping.setDirection(self.getDirection())
92 if self.size == None:
93 self.size = 0
94 if "identity" in subMapping.getTagNames() and "identity" not in self.getTagNames():
95 self.setTagValue("identity", subMapping.getTagValue("identity"))
96 elif "identity" in subMapping.getTagNames() and subMapping.size != None:
97 self.setTagValue("identity", (self.getTagValue("identity") * self.size + subMapping.getTagValue("identity") * subMapping.size) / (self.size + subMapping.size))
98 if subMapping.size != None:
99 self.size += subMapping.size
100 if "nbMismatches" in subMapping.getTagNames() and "nbMismatches" not in self.getTagNames():
101 self.setTagValue("nbMismatches", subMapping.getTagValue("nbMismatches"))
102 elif "nbMismatches" in subMapping.getTagNames():
103 self.setTagValue("nbMismatches", self.getTagValue("nbMismatches") + subMapping.getTagValue("nbMismatches"))
104 if "nbGaps" in subMapping.getTagNames() and "nbGaps" not in self.getTagNames():
105 self.setTagValue("nbGaps", subMapping.getTagValue("nbGaps"))
106 elif "nbGaps" in subMapping.getTagNames():
107 self.setTagValue("nbGaps", self.getTagValue("nbGaps") + subMapping.getTagValue("nbGaps"))
108
109
110 def setDirection(self, direction):
111 for subMapping in self.subMappings:
112 subMapping.setDirection(direction)
113
114
115 def getDirection(self):
116 if not self.subMappings:
117 raise Exception("Error! Mapping '%s' has no submapping" % (self))
118 return self.subMappings[0].getDirection()
119
120
121 def setSize(self, size):
122 self.size = size
123 if "identity" in self.getTagNames():
124 self.setTagValue("nbMismatches", self.size - round(self.size * self.getTagValue("identity") / 100.0))
125
126
127 def setTagValue(self, name, value):
128 self.tags[name] = value
129 self.transcript = None
130
131
132 def getTagValue(self, name):
133 return self.tags[name]
134
135
136 def getTagNames(self):
137 return self.tags.keys()
138
139
140 def setIdentity(self, identity):
141 self.setTagValue("identity", identity)
142 if self.size != None and "nbMismatches" not in self.getTagNames():
143 nbMismatches = 0 if self.size == 0 else self.size - round(self.size * self.getTagValue("identity") / 100.0)
144 self.setTagValue("nbMismatches", nbMismatches)
145
146
147 def setNbOccurrences(self, nbOccurrences):
148 self.setTagValue("nbOccurrences", nbOccurrences)
149
150
151 def setNbMismatches(self, nbMismatches):
152 self.setTagValue("nbMismatches", nbMismatches)
153 if self.size != None and "identity" not in self.getTagNames():
154 identity = 100 if self.size == 0 else (self.size - self.getTagValue("nbMismatches")) / float(self.size) * 100
155 self.setTagValue("identity", identity)
156
157
158 def setNbGaps(self, nbGaps):
159 self.setTagValue("nbGaps", nbGaps)
160
161
162 def setRank(self, rank):
163 self.setTagValue("rank", rank)
164
165
166 def setEvalue(self, evalue):
167 self.setTagValue("evalue", evalue)
168
169
170 def setOccurrence(self, occurrence):
171 self.setTagValue("occurrence", occurrence)
172
173
174 def setBestRegion(self, bestRegion):
175 self.setTagValue("bestRegion", bestRegion)
176
177
178 def mergeExons(self, distance):
179 previousSubMapping = None
180 subMappings = []
181 for subMapping in self.subMappings:
182 if previousSubMapping == None:
183 subMappings.append(subMapping)
184 previousSubMapping = subMapping
185 else:
186 targetDistance = subMapping.targetInterval.getDistance(previousSubMapping.targetInterval)
187 queryDistance = subMapping.queryInterval.getDistance(previousSubMapping.queryInterval)
188 if targetDistance <= distance:
189 self.setTagValue("nbGaps", self.getTagValue("nbGaps") + queryDistance)
190 previousSubMapping.merge(subMapping)
191 else:
192 subMappings.append(subMapping)
193 previousSubMapping = subMapping
194 self.subMappings = subMappings
195
196
197 def getTranscript(self):
198 """
199 Extract a transcript from this mapping
200 @return: a transcript
201 """
202 if self.transcript != None:
203 return self.transcript
204 self.transcript = Transcript()
205 self.transcript.copy(self.targetInterval)
206 self.transcript.setDirection(self.getDirection())
207 self.transcript.setName(self.queryInterval.getName())
208 self.transcript.removeExons()
209 if len(self.subMappings) > 1:
210 for subMapping in self.subMappings:
211 self.transcript.addExon(subMapping.targetInterval)
212 cpt = 1
213 for exon in self.transcript.exons:
214 exon.setDirection(self.transcript.getDirection())
215 exon.setName("%s-exon%d" % (self.transcript.getName(), cpt))
216 exon.setChromosome(self.transcript.getChromosome())
217 cpt += 1
218 self.transcript.setDirection(self.getDirection())
219 self.transcript.sortExons()
220 for tag in self.tags:
221 if "bestRegion" not in self.getTagNames():
222 self.transcript.setTagValue("bestRegion", "(self)")
223 self.transcript.setTagValue(tag, self.getTagValue(tag))
224 return self.transcript
225
226
227 def getChromosome(self):
228 if not self.subMappings:
229 raise Exception("Error! Mapping '%s' has no submapping" % (self))
230 return self.subMappings[0].targetInterval.getChromosome()
231
232
233
234 def getErrorScore(self):
235 return self.getTagValue("nbGaps") * 3 + self.getTagValue("nbMismatches") + (len(self.subMappings) - 1) * 0.1
236
237
238 def printGBrowseReference(self):
239 return self.getTranscript().printGBrowseReference()
240
241
242 def printGBrowseLine(self):
243 return self.getTranscript().printGBrowseLine()
244
245
246 def printGBrowse(self):
247 return self.getTranscript().printGBrowse()
248
249
250 def printBed(self):
251 return self.getTranscript().printBed()
252
253
254 def __str__(self):
255 return "%s ---- %s" % (str(self.getTranscript()), ", ". join([str(submapping) for submapping in self.subMappings]))