#!/usr/bin/env python

# Copyright INRA (Institut National de la Recherche Agronomique)
# http://www.inra.fr
# http://urgi.versailles.inra.fr
#
# This software is governed by the CeCILL license under French law and
# abiding by the rules of distribution of free software.  You can  use, 
# modify and/ or redistribute the software under the terms of the CeCILL
# license as circulated by CEA, CNRS and INRIA at the following URL
# "http://www.cecill.info". 
#
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# modify and redistribute granted by the license, users are provided only
# with a limited warranty  and the software's author,  the holder of the
# economic rights,  and the successive licensors  have only  limited
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# with loading,  using,  modifying and/or developing or reproducing the
# software by the user in light of its specific status of free software,
# that may mean  that it is complicated to manipulate,  and  that  also
# therefore means  that it is reserved for developers  and  experienced
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from commons.core.LoggerFactory import LoggerFactory
from commons.core.utils.RepetOptionParser import RepetOptionParser
import subprocess

LOG_DEPTH = "repet.tools"

##Launch BLASTER
#
class LaunchBlaster(object):
    
    def __init__(self, queryFileName = "", subjectFileName = "", evalue = 1e-300, identity = 90, length = 100, doAllByall = False, type = "ncbi", nbCPU = 1, program="blastn",extraParams="", doClean = False, verbosity = 0):
        self._queryFileName = queryFileName
        self.setSubjectFileName(subjectFileName)
        self._eValue = evalue
        self._identity = identity
        self._length = length
        self._doAllByall = doAllByall
        self._blastType = type
        self._program = program
        self._extraParams = extraParams
        self._nbCPU = nbCPU
        self._doClean = doClean
        self._verbosity = verbosity
        self._log = LoggerFactory.createLogger("%s.%s" % (LOG_DEPTH, self.__class__.__name__), self._verbosity)
        
    def setAttributesFromCmdLine(self):
        description = "Launch Blaster."
        epilog = "\nExample 1: launch without verbosity and keep temporary files.\n"
        epilog += "\t$ python LaunchBlaster.py -q query.fa -v 0"
        epilog += "\n\t"
        epilog += "\nExample 2: launch with verbosity to have errors (level 1) and basic information (level 2), and delete temporary files.\n"
        epilog += "\t$ python LaunchBlaster.py -q query.fa -s nr.fa -c -v 2"
        parser = RepetOptionParser(description = description, epilog = epilog)
        parser.add_option("-q", "--query",      dest = "query",         action = "store",       type = "string", help = "query fasta file name [compulsory] [format: fasta]",       default = "")
        parser.add_option("-s", "--subject",    dest = "subject",       action = "store",       type = "string", help = "subject fasta file name [default: query] [format: fasta]", default = "")
        parser.add_option("-e", "--evalue",     dest = "evalue",        action = "store",       type = "string", help = "Blast e-value [default: 1e-300]",                           default = "1e-300")
        parser.add_option("-d", "--id",         dest = "identity",      action = "store",       type = "int",    help = "Blast identity [default: 90]",                             default = 90)
        parser.add_option("-l", "--length",     dest = "length",        action = "store",       type = "int",    help = "Minimal hit length [default: 100]",                        default = 100)
        parser.add_option("-a", "--aba",        dest = "doAllByall",    action = "store_true",                   help = "all-by-all Blast [default: False]",                        default = False)
        parser.add_option("-t", "--type",       dest = "type",          action = "store",       type = "string", help = "Blast type [ncbi, wu, blastplus] [default: ncbi]",         default = "ncbi")
        parser.add_option("-u", "--program",    dest = "program",       action = "store",       type = "string", help = "Blast program type [blastn, blastx, blastx] [default: blastn]",         default = "blastn")
        parser.add_option("-x", "--extraParams",dest = "extraParams",   action = "store",       type = "string", help = "Additional blast program parameters[default: '']",         default = "")
        parser.add_option("-n", "--ncpu",       dest = "cpu",           action = "store",       type = "int",    help = "Number of CPUs to use [default: 1]",                       default = 1)
        parser.add_option("-c", "--clean",      dest = "doClean",       action = "store_true",                   help = "clean temporary files [default: False]",                   default = False)
        parser.add_option("-v", "--verbosity",  dest = "verbosity",     action = "store",       type = "int",    help = "verbosity [default: 1]",                                   default = 1)
        options = parser.parse_args()[0]
        self._setAttributesFromOptions(options)
        
    def _setAttributesFromOptions(self, options):
        self.setQueryFileName(options.query)
        self.setSubjectFileName(options.subject)
        self.setEvalue(options.evalue)
        self.setIdentity(options.identity)
        self.setLength(options.length)
        self.setDoAllByall(options.doAllByall)
        self.setType(options.type)
        self.setProgram(options.program)
        self.setExtraParams(options.extraParams)
        self.setCPU(options.cpu)
        self.setDoClean(options.doClean)
        self.setVerbosity(options.verbosity)
        
    
    def setQueryFileName(self, queryFileName):
        self._queryFileName = queryFileName
        
    def setSubjectFileName(self, subjectFileName):
        if subjectFileName == "":
            self._subjectFileName = self._queryFileName
        else:
            self._subjectFileName = subjectFileName
        
    def setEvalue(self, evalue):
        self._eValue = evalue
        
    def setIdentity(self, identity):
        self._identity = identity
        
    def setLength(self, length):
        self._length = length
        
    def setDoAllByall(self, doAllByall):
        self._doAllByall = doAllByall
        
    def setType(self, blastType):
        self._blastType = blastType
        
    def setProgram(self, program):
        self._program = program
        
    def setExtraParams(self, extraParams):
        self._extraParams = extraParams
        
    def setCPU(self, cpu):
        self._nbCPU = cpu
        
    def setDoClean(self, doClean):
        self._doClean = doClean
        
    def setVerbosity(self, verbosity):
        self._verbosity = verbosity
        
    def _checkOptions(self):
        if self._queryFileName == "":
            self._logAndRaise("ERROR: Missing input fasta file name")
        
        lBlastType = ["ncbi", "wu", "blastplus"]    
        if self._blastType.lower() not in lBlastType:
            self._logAndRaise("ERROR: unknown Blast type '%s' - correct values are %s" % (self._blastType, lBlastType))
            
    def _logAndRaise(self, errorMsg):
        self._log.error(errorMsg)
        raise Exception(errorMsg)

    def _getBlasterCmd(self):
        lArgs = []
        lArgs.append("-n %s" % self._program)
        lArgs.append("-q %s" % self._queryFileName)
        lArgs.append("-s %s" % self._subjectFileName)
        lArgs.append("-B %s" % self._queryFileName)
        if self._doAllByall:
            lArgs.append("-a")
        lArgs.append("-E %s" % self._eValue)
        lArgs.append("-L %s" % self._length)
        lArgs.append("-I %s" % self._identity)
        if self._blastType == "ncbi": 
            lArgs.append("-N")
            lArgs.append("-p '-a %s %s'" % (self._nbCPU, self._extraParams))
        elif self._blastType == "wu":
            lArgs.append("-W")
            lArgs.append("-p '-cpus=%s %s'" % (self._nbCPU, self._extraParams))
        elif self._blastType == "blastplus":
            lArgs.append("-X")
            lArgs.append("-p '-num_threads %s %s'" % (self._nbCPU, self._extraParams))
# TODO: check the check option at the beginning of step 2 to allow to launch megablast for blast and blast+
#    elif config.get(sectionName, "blast") == "mega":
#        lArgs.append("-N")
#        lArgs.append("-n megablast")
#    elif config.get(sectionName, "blast") == "megablastplus":
#        lArgs.append("-X")
#        lArgs.append("-n megablast")
        if self._doClean:
            lArgs.append("-c")
        lArgs.append("-v %i" % (self._verbosity - 1))
        return self._getSystemCommand("blaster", lArgs)
    
    def _getSystemCommand(self, prg, lArgs):
        systemCmd = prg 
        for arg in lArgs:
            systemCmd += " " + arg
        return systemCmd
                    
    def run(self):
        LoggerFactory.setLevel(self._log, self._verbosity)
        self._checkOptions()
        self._log.info("START LaunchBlaster")
        self._log.debug("Query file name: %s" % self._queryFileName)
        self._log.debug("Subject file name: %s" % self._subjectFileName)
        if self._doClean:
            self._log.warning("Files will be cleaned")
        cmd = self._getBlasterCmd()
        process = subprocess.Popen(cmd, shell = True)
        self._log.debug("Running : %s" % cmd)
        process.communicate()
        if process.returncode != 0:
            self._logAndRaise("ERROR when launching '%s'" % cmd)
        self._log.info("END LaunchBlaster")

if __name__ == "__main__":
    iLaunch = LaunchBlaster()
    iLaunch.setAttributesFromCmdLine()
    iLaunch.run()