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author davidvanzessen
date Thu, 22 Dec 2016 09:39:27 -0500
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children ba33b94637ca
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+<html>
+
+<head>
+<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
+<meta name=Generator content="Microsoft Word 14 (filtered)">
+<style>
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+</head>
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+<body lang=EN-US>
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+<div class=WordSection1>
+
+<p class=MsoNormalCxSpFirst style='text-align:justify'><b><u><span lang=EN-GB
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>SHM
+frequency tab</span></u></b></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span lang=EN-GB
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs</span></b></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These
+graphs give insight into the level of SHM. The data represented in these graphs
+can be downloaded in the download tab. <a name="OLE_LINK24"></a><a
+name="OLE_LINK23"></a><a name="OLE_LINK90"></a><a name="OLE_LINK89">More
+information on the values found in healthy individuals of different ages can be
+found in IJspeert and van Schouwenburg et al, PMID: 27799928. </a></span></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Frequency
+scatter plot</span></u></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
+dot plot showing the percentage of SHM in each transcript divided into the
+different (sub)classes. </span><span lang=NL style='font-size:12.0pt;
+line-height:115%;font-family:"Times New Roman","serif"'>In the graph each dot
+represents an individual transcript.</span></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Mutation
+frequency by class</span></u></p>
+
+<p class=MsoNormalCxSpLast style='text-align:justify'><span lang=EN-GB
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A
+bar graph showing the percentage of transcripts that contain 0%, 0-2%, 2-5%,
+5-10% 10-15%, 15-20% or more than 20% SHM for each subclass. </span></p>
+
+<p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
+font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
+Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
+Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
+of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
+Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
+href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
+style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
+href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
+style='color:windowtext'>Link</span></a>]</span></p>
+
+</div>
+
+</body>
+
+</html>