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| author | dcouvin |
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| date | Wed, 08 Dec 2021 01:46:07 +0000 |
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#Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut fusA fusA 16 ATG M I Fusidic acid 20855746 Target modification fusA_H457Y fusA fusA 67 GCA A T Fusidic acid 12519196 Target modification fusA_P406L;fusA_H457Y fusA fusA 70 GCA A V Fusidic acid 20855746 Target modification fusA_H457Y fusA fusA 71 GCT A V Fusidic acid 20855746 Target modification fusA_P406L;fusA_D189G,fusA_P406L fusA fusA 76 CGT R C Fusidic acid 20855746 Target modification fusA_H457Y fusA fusA 90 GTA V I Fusidic acid 19289529 Target modification fusA fusA 114 CCT P H Fusidic acid 17923494 Target modification fusA fusA 115 CAA Q L Fusidic acid 17923494 Target modification fusA fusA 189 GAT D G Fusidic acid 19289529 Target modification fusA_V90I,fusA_P406L fusA fusA 233 GAA E Q Fusidic acid 21149625 Target modification fusA_V90I,fusA_L461S fusA fusA 326 ACA T I Fusidic acid 24501024 Target modification fusA_E468V fusA fusA 373 GAT D N Fusidic acid 21149625 Target modification fusA_H457Y fusA fusA 376 GCT A V Fusidic acid 20855746 Target modification fusA_L456F;fusA_L461F,fusA_A655P,fusA_D463G fusA fusA 385 ACT T N Fusidic acid 17923494 Target modification fusA fusA 404 CCT P L,Q Fusidic acid 17923494,21 Target modification fusA fusA 404 CCA P L,Q Fusidic acid 17923494,21 Target modification fusA fusA 406 CCA P L Fusidic acid 17923494 Target modification fusA fusA 416 TCT S F Fusidic acid 12519196 Target modification fusA_H457Y fusA fusA 434 GAC D N Fusidic acid 17923494 Target modification fusA fusA 436 ACA T I Fusidic acid 17923494 Target modification fusA fusA 438 CAT H N Fusidic acid 17923494 Target modification fusA fusA 444 GAA E K Fusidic acid 20855746 Target modification fusA fusA 444 GAA E V Fusidic acid 20855746 Target modification fusA_L461F fusA fusA 451 GGT G V Fusidic acid 20855746 Target modification fusA fusA 452 GGT G S,C Fusidic acid 17923494,18 Target modification fusA fusA 453 ATG M I Fusidic acid 20855746 Target modification fusA fusA 456 CTT L F Fusidic acid 17923494 Target modification fusA fusA 457 CAC H Y,Q Fusidic acid 17923494,21 Target modification fusA fusA 461 TTA L K,S Fusidic acid 12519196,21 Target modification fusA fusA 461 TTA L F Fusidic acid 20855746 Target modification fusA_E444V;fusA_H457Q;fusA_A655P,fusA_A376V,fusA_D463G fusA fusA 463 GAC D G Fusidic acid 24501024 Target modification fusA_A655P,fusA_A376V,fusA_L461F fusA fusA 464 CGT R C,H,S Fusidic acid 17923494,1792349,1792349 Target modification fusA fusA 468 GAA E V Fusidic acid 24501024 Target modification fusA_T326I fusA fusA 473 TGT C S Fusidic acid 20855746 Target modification fusA_L461K fusA fusA 478 CCA P S Fusidic acid 20855746 Target modification fusA fusA 556 GGT G S Fusidic acid 21569422 Target modification fusA fusA 617 GGT G D Fusidic acid 17923494 Target modification fusA fusA 651 ATG M I Fusidic acid 20855746 Target modification fusA fusA 652 TTC F S Fusidic acid 12519196 Target modification fusA_Y654N fusA fusA 654 TAT Y N Fusidic acid 12519196 Target modification fusA_F652S fusA fusA 655 GCA A E Fusidic acid 17923494 Target modification fusA fusA 655 GCA A V Fusidic acid 12519196 Target modification fusA_V90I,fusA_H457Q,fusA_L461K fusA fusA 655 GCA A P Fusidic acid 24501024 Target modification fusA_L461F,fusA_A376V,fusA_D463G fusA fusA 656 ACA T K Fusidic acid 21149625 Target modification fusA fusA 659 CGT R C,H,S Fusidic acid 17923494,1792349,1792349 Target modification fusA fusA 659 CGT R L Fusidic acid 21569422 Target modification fusA_H457Y fusA fusA 664 GGT G S Fusidic acid 17923494 Target modification gyrA gyrA 84 TCA S L,A Ciprofloxacin 2174869,79 Target modification gyrA gyrA 85 TCT S P Ciprofloxacin 2174869 Target modification gyrA gyrA 88 GAA E K Ciprofloxacin 15848290 Target modification gyrA gyrA 88 GAA E L Ciprofloxacin 16769192 Target modification Levofloxacin resistance (and not tested for ciprofloxacin) in combination with gyrA_S84L,grlA_S80Y,grlA_E84G gyrA_S84L,grlA_S80Y,grlA_E84G gyrA gyrA 88 GAA E G Ciprofloxacin 15848290,2 Target modification Levofloxacin resistance (and not tested for ciprofloxacin) in combination with gyrA_S84L,grlA_S80Y,grlA_E84G grlA_S80F.Y;gyrA_S84L,grlA_S80F,grlA_E84K gyrA gyrA 106 GGC G D Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_S80F grlA grlA 41 GTA V G Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_I45M,grlA_S80F,grlB_E422D grlA grlA 45 ATT I M Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_V41G,grlA_S80F,grlB_E422D;grlA_S80F,grlB_E422D grlA grlA 48 GCA A T Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_S80F grlA grlA 79 GAC D V Unknown 12812718 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_E88K,grlA_S80F;gyrA_S84L,grlA_S80Y grlA grlA 80 TCC S F,Y Ciprofloxacin 15848290,95 Target modification grlA grlA 83 TAC Y N Ciprofloxacin 20407243 Target modification gyrA_S84L,grlA_S80F grlA grlA 84 GAA E K Ciprofloxacin 15848290,20407243,15848290,9511037,20407243 Target modification gyrA_S84L,grlA_S80F.Y;gyrA_S84L,gyrA_S85P,grlA_S80F;gyrA_S84L;grlA_S80F;gyrA_S84L,gyrA_E88G,grlA_S80F grlA grlA 84 GAA E G Ciprofloxacin 21996946,16769192,21996946,22032541 Target modification Levofloxacin resistance (and not tested for ciprofloxacin) in combination with gyrA_S84L,gyrA_E88L,grlA_S80Y gyrA_S84L,gyrA_S85P,grlA_S80Y;gyrA_S84L,gyrA_E88K.L,grlA_S80Y;gyrA_S84L,grlA_S80Y grlA grlA 84 GAA E V Ciprofloxacin 9593159,204 Target modification gyrA_E88K,grlA_S80F;gyrA_S84L,grlA_S80F grlA grlA 84 GAA E L Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,gyrA_S85P,grlA_S80F grlA grlA 108 AGT S N Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,gyrA_S85P,grlA_S80F grlA grlA 116 GCA A E Ciprofloxacin 11083638 Target modification gyrA_S84L grlB grlB 422 GAA E D Unknown 9593159 Target modification gyrA_S84L,grlA_V41G,grlA_I45M,grlA_S80F;grlA_I45M,grlA_S80F grlB grlB 432 GAT D V,N,H Ciprofloxacin 20407243,21996946,21996946 Target modification gyrA_S84L,gyrA_S85P,grlA_S80F.Y grlB grlB 432 GAT D G Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_S80F grlB grlB 443 GAC D E Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,grlA_E84K,grlB_R444S grlB grlB 444 CGC R S Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,grlA_E84K,grlB_D443E grlB grlB 451 CCA P S Unknown 12812718 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,grlA_S80F grlB grlB 470 AAT N D Ciprofloxacin 9449271 Target modification gyrA_S84L grlB grlB 585 CCT P S Ciprofloxacin 20407243 Target modification gyrA_S84L,grlA_S80F dfrB dfrB 21 TTA L V Trimethoprim 29307840,91 Target modification dfrB_F99Y;dfrB_N60I,dfrB_F99Y dfrB dfrB 31 CAT H N Trimethoprim 22491688 Target modification dfrB dfrB 41 TTA L F Trimethoprim 19383727 Target modification dfrB dfrB 60 AAT N I Trimethoprim 9054967 Target modification dfrB_L21V,dfrB_F99Y dfrB dfrB 99 TTT F S,Y,I Trimethoprim 19383727,19383727,22491688 Target modification dfrB dfrB 150 CAT H R Trimethoprim 19383727 Target modification ileS ileS 588 GTT V F Mupirocin 11796355 Target modification ileS ileS 631 GTT V F Mupirocin 11796355 Target modification rpoB rpoB 463 AGC S P Rifampicin 21393177 Target modification rpoB rpoB 464 TCT S P Rifampicin 11157898 Target modification rpoB rpoB 465 CAA Q K Rifampicin 21393177 Target modification rpoB rpoB 465 CAA Q R Rifampicin 11157898 Target modification rpoB_H481N,rpoB_S529L rpoB rpoB 466 TTA L S Rifampicin 11157898 Target modification rpoB_H481N rpoB rpoB 468 CAA Q K,R,L Rifampicin 11157898,11157898,11157898 Target modification rpoB rpoB 470 ATG M T Rifampicin 18716806 Target modification rpoB_D471G rpoB rpoB 471 GAC D G Rifampicin 18716806 Target modification rpoB_M470T rpoB rpoB 471 GAC D Y Rifampicin 11157898 Target modification rpoB rpoB 473 GCA A T Rifampicin 11157898 Target modification rpoB_H481N,rpoB_A477T rpoB rpoB 474 AAT N K Rifampicin 21393177 Target modification rpoB_ins475 rpoB rpoB 477 GCT A D,V Rifampicin 11157898,98 Target modification rpoB rpoB 477 GCT A T Rifampicin 11157898,2 Target modification rpoB_H481N,rpoB_A473T;rpoB_H481N rpoB rpoB 481 CAT H N,Y,D Rifampicin 11157898,11157898,21393177 Target modification rpoB rpoB 484 CGT R H Rifampicin 11157898 Target modification rpoB rpoB 486 TCA S L Rifampicin 11157898 Target modification rpoB rpoB 527 ATT I F Rifampicin 11157898 Target modification rpoB rpoB 527 ATT I M,L Rifampicin 11157898,2 Target modification rpoB_H481N rpoB rpoB 529 TCA S L Rifampicin 11157898 Target modification rpoB_H481N rpoB rpoB 550 GAT D G Rifampicin 9756760 Target modification pbp2 pbp2 569 TCT S A Cefoxitin 7695289 Target modification MRSA phenotype pbp4 pbp4 183 GAA E A Cefazolin,Ceftriaxone,Ceftaroline 29360990 Target protection pbp4 pbp4 241 TTC F R Cefazolin,Ceftriaxone,Ceftaroline 29360990 Target protection 23S 23S 2500 T T A Linezolid 15216466 Target modification 23S 23S 2576 G G T Linezolid,Quinupristin+Dalfopristin,Chloramphenicol 18212098 Target modification # Indels pbp4_promoter_size_304bp pbp4 promoter -290 - ins ATTTATATGATAGAATATTTCTATTGCATTTTTTGT Cefazolin,Ceftriaxone,Ceftaroline 28373193 Target protection 36 bp duplication (ATTTATATGATAGAATATTTCTATTGCATTTTTTGT) at position -290 rpoB rpoB 475 - ins G Rifampicin 21393177 Target modification rpoB_N474K rpoB rpoB 475 - ins H Rifampicin 18716806 Target modification