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1 #Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut
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2 fusA fusA 16 ATG M I Fusidic acid 20855746 Target modification fusA_H457Y
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3 fusA fusA 67 GCA A T Fusidic acid 12519196 Target modification fusA_P406L;fusA_H457Y
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4 fusA fusA 70 GCA A V Fusidic acid 20855746 Target modification fusA_H457Y
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5 fusA fusA 71 GCT A V Fusidic acid 20855746 Target modification fusA_P406L;fusA_D189G,fusA_P406L
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6 fusA fusA 76 CGT R C Fusidic acid 20855746 Target modification fusA_H457Y
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7 fusA fusA 90 GTA V I Fusidic acid 19289529 Target modification
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8 fusA fusA 114 CCT P H Fusidic acid 17923494 Target modification
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9 fusA fusA 115 CAA Q L Fusidic acid 17923494 Target modification
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10 fusA fusA 189 GAT D G Fusidic acid 19289529 Target modification fusA_V90I,fusA_P406L
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11 fusA fusA 233 GAA E Q Fusidic acid 21149625 Target modification fusA_V90I,fusA_L461S
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12 fusA fusA 326 ACA T I Fusidic acid 24501024 Target modification fusA_E468V
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13 fusA fusA 373 GAT D N Fusidic acid 21149625 Target modification fusA_H457Y
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14 fusA fusA 376 GCT A V Fusidic acid 20855746 Target modification fusA_L456F;fusA_L461F,fusA_A655P,fusA_D463G
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15 fusA fusA 385 ACT T N Fusidic acid 17923494 Target modification
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16 fusA fusA 404 CCT P L,Q Fusidic acid 17923494,21 Target modification
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17 fusA fusA 404 CCA P L,Q Fusidic acid 17923494,21 Target modification
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18 fusA fusA 406 CCA P L Fusidic acid 17923494 Target modification
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19 fusA fusA 416 TCT S F Fusidic acid 12519196 Target modification fusA_H457Y
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20 fusA fusA 434 GAC D N Fusidic acid 17923494 Target modification
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21 fusA fusA 436 ACA T I Fusidic acid 17923494 Target modification
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22 fusA fusA 438 CAT H N Fusidic acid 17923494 Target modification
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23 fusA fusA 444 GAA E K Fusidic acid 20855746 Target modification
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24 fusA fusA 444 GAA E V Fusidic acid 20855746 Target modification fusA_L461F
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25 fusA fusA 451 GGT G V Fusidic acid 20855746 Target modification
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26 fusA fusA 452 GGT G S,C Fusidic acid 17923494,18 Target modification
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27 fusA fusA 453 ATG M I Fusidic acid 20855746 Target modification
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28 fusA fusA 456 CTT L F Fusidic acid 17923494 Target modification
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29 fusA fusA 457 CAC H Y,Q Fusidic acid 17923494,21 Target modification
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30 fusA fusA 461 TTA L K,S Fusidic acid 12519196,21 Target modification
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31 fusA fusA 461 TTA L F Fusidic acid 20855746 Target modification fusA_E444V;fusA_H457Q;fusA_A655P,fusA_A376V,fusA_D463G
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32 fusA fusA 463 GAC D G Fusidic acid 24501024 Target modification fusA_A655P,fusA_A376V,fusA_L461F
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33 fusA fusA 464 CGT R C,H,S Fusidic acid 17923494,1792349,1792349 Target modification
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34 fusA fusA 468 GAA E V Fusidic acid 24501024 Target modification fusA_T326I
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35 fusA fusA 473 TGT C S Fusidic acid 20855746 Target modification fusA_L461K
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36 fusA fusA 478 CCA P S Fusidic acid 20855746 Target modification
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37 fusA fusA 556 GGT G S Fusidic acid 21569422 Target modification
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38 fusA fusA 617 GGT G D Fusidic acid 17923494 Target modification
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39 fusA fusA 651 ATG M I Fusidic acid 20855746 Target modification
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40 fusA fusA 652 TTC F S Fusidic acid 12519196 Target modification fusA_Y654N
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41 fusA fusA 654 TAT Y N Fusidic acid 12519196 Target modification fusA_F652S
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42 fusA fusA 655 GCA A E Fusidic acid 17923494 Target modification
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43 fusA fusA 655 GCA A V Fusidic acid 12519196 Target modification fusA_V90I,fusA_H457Q,fusA_L461K
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44 fusA fusA 655 GCA A P Fusidic acid 24501024 Target modification fusA_L461F,fusA_A376V,fusA_D463G
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45 fusA fusA 656 ACA T K Fusidic acid 21149625 Target modification
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46 fusA fusA 659 CGT R C,H,S Fusidic acid 17923494,1792349,1792349 Target modification
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47 fusA fusA 659 CGT R L Fusidic acid 21569422 Target modification fusA_H457Y
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48 fusA fusA 664 GGT G S Fusidic acid 17923494 Target modification
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49 gyrA gyrA 84 TCA S L,A Ciprofloxacin 2174869,79 Target modification
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50 gyrA gyrA 85 TCT S P Ciprofloxacin 2174869 Target modification
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51 gyrA gyrA 88 GAA E K Ciprofloxacin 15848290 Target modification
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52 gyrA gyrA 88 GAA E L Ciprofloxacin 16769192 Target modification Levofloxacin resistance (and not tested for ciprofloxacin) in combination with gyrA_S84L,grlA_S80Y,grlA_E84G gyrA_S84L,grlA_S80Y,grlA_E84G
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53 gyrA gyrA 88 GAA E G Ciprofloxacin 15848290,2 Target modification Levofloxacin resistance (and not tested for ciprofloxacin) in combination with gyrA_S84L,grlA_S80Y,grlA_E84G grlA_S80F.Y;gyrA_S84L,grlA_S80F,grlA_E84K
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54 gyrA gyrA 106 GGC G D Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_S80F
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55 grlA grlA 41 GTA V G Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_I45M,grlA_S80F,grlB_E422D
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56 grlA grlA 45 ATT I M Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_V41G,grlA_S80F,grlB_E422D;grlA_S80F,grlB_E422D
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57 grlA grlA 48 GCA A T Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_S80F
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58 grlA grlA 79 GAC D V Unknown 12812718 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_E88K,grlA_S80F;gyrA_S84L,grlA_S80Y
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59 grlA grlA 80 TCC S F,Y Ciprofloxacin 15848290,95 Target modification
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60 grlA grlA 83 TAC Y N Ciprofloxacin 20407243 Target modification gyrA_S84L,grlA_S80F
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61 grlA grlA 84 GAA E K Ciprofloxacin 15848290,20407243,15848290,9511037,20407243 Target modification gyrA_S84L,grlA_S80F.Y;gyrA_S84L,gyrA_S85P,grlA_S80F;gyrA_S84L;grlA_S80F;gyrA_S84L,gyrA_E88G,grlA_S80F
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62 grlA grlA 84 GAA E G Ciprofloxacin 21996946,16769192,21996946,22032541 Target modification Levofloxacin resistance (and not tested for ciprofloxacin) in combination with gyrA_S84L,gyrA_E88L,grlA_S80Y gyrA_S84L,gyrA_S85P,grlA_S80Y;gyrA_S84L,gyrA_E88K.L,grlA_S80Y;gyrA_S84L,grlA_S80Y
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63 grlA grlA 84 GAA E V Ciprofloxacin 9593159,204 Target modification gyrA_E88K,grlA_S80F;gyrA_S84L,grlA_S80F
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64 grlA grlA 84 GAA E L Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,gyrA_S85P,grlA_S80F
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65 grlA grlA 108 AGT S N Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,gyrA_S85P,grlA_S80F
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66 grlA grlA 116 GCA A E Ciprofloxacin 11083638 Target modification gyrA_S84L
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67 grlB grlB 422 GAA E D Unknown 9593159 Target modification gyrA_S84L,grlA_V41G,grlA_I45M,grlA_S80F;grlA_I45M,grlA_S80F
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68 grlB grlB 432 GAT D V,N,H Ciprofloxacin 20407243,21996946,21996946 Target modification gyrA_S84L,gyrA_S85P,grlA_S80F.Y
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69 grlB grlB 432 GAT D G Ciprofloxacin 9593159 Target modification gyrA_S84L,grlA_S80F
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70 grlB grlB 443 GAC D E Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,grlA_E84K,grlB_R444S
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71 grlB grlB 444 CGC R S Unknown 16769192 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,grlA_E84K,grlB_D443E
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72 grlB grlB 451 CCA P S Unknown 12812718 Target modification Levofloxacin resistance, not tested for ciprofloxacin gyrA_S84L,grlA_S80F
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73 grlB grlB 470 AAT N D Ciprofloxacin 9449271 Target modification gyrA_S84L
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74 grlB grlB 585 CCT P S Ciprofloxacin 20407243 Target modification gyrA_S84L,grlA_S80F
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75 dfrB dfrB 21 TTA L V Trimethoprim 29307840,91 Target modification dfrB_F99Y;dfrB_N60I,dfrB_F99Y
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76 dfrB dfrB 31 CAT H N Trimethoprim 22491688 Target modification
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77 dfrB dfrB 41 TTA L F Trimethoprim 19383727 Target modification
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78 dfrB dfrB 60 AAT N I Trimethoprim 9054967 Target modification dfrB_L21V,dfrB_F99Y
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79 dfrB dfrB 99 TTT F S,Y,I Trimethoprim 19383727,19383727,22491688 Target modification
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80 dfrB dfrB 150 CAT H R Trimethoprim 19383727 Target modification
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81 ileS ileS 588 GTT V F Mupirocin 11796355 Target modification
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82 ileS ileS 631 GTT V F Mupirocin 11796355 Target modification
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83 rpoB rpoB 463 AGC S P Rifampicin 21393177 Target modification
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84 rpoB rpoB 464 TCT S P Rifampicin 11157898 Target modification
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85 rpoB rpoB 465 CAA Q K Rifampicin 21393177 Target modification
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86 rpoB rpoB 465 CAA Q R Rifampicin 11157898 Target modification rpoB_H481N,rpoB_S529L
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87 rpoB rpoB 466 TTA L S Rifampicin 11157898 Target modification rpoB_H481N
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88 rpoB rpoB 468 CAA Q K,R,L Rifampicin 11157898,11157898,11157898 Target modification
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89 rpoB rpoB 470 ATG M T Rifampicin 18716806 Target modification rpoB_D471G
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90 rpoB rpoB 471 GAC D G Rifampicin 18716806 Target modification rpoB_M470T
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91 rpoB rpoB 471 GAC D Y Rifampicin 11157898 Target modification
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92 rpoB rpoB 473 GCA A T Rifampicin 11157898 Target modification rpoB_H481N,rpoB_A477T
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93 rpoB rpoB 474 AAT N K Rifampicin 21393177 Target modification rpoB_ins475
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94 rpoB rpoB 477 GCT A D,V Rifampicin 11157898,98 Target modification
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95 rpoB rpoB 477 GCT A T Rifampicin 11157898,2 Target modification rpoB_H481N,rpoB_A473T;rpoB_H481N
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96 rpoB rpoB 481 CAT H N,Y,D Rifampicin 11157898,11157898,21393177 Target modification
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97 rpoB rpoB 484 CGT R H Rifampicin 11157898 Target modification
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98 rpoB rpoB 486 TCA S L Rifampicin 11157898 Target modification
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99 rpoB rpoB 527 ATT I F Rifampicin 11157898 Target modification
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100 rpoB rpoB 527 ATT I M,L Rifampicin 11157898,2 Target modification rpoB_H481N
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101 rpoB rpoB 529 TCA S L Rifampicin 11157898 Target modification rpoB_H481N
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102 rpoB rpoB 550 GAT D G Rifampicin 9756760 Target modification
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103 pbp2 pbp2 569 TCT S A Cefoxitin 7695289 Target modification MRSA phenotype
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104 pbp4 pbp4 183 GAA E A Cefazolin,Ceftriaxone,Ceftaroline 29360990 Target protection
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105 pbp4 pbp4 241 TTC F R Cefazolin,Ceftriaxone,Ceftaroline 29360990 Target protection
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106 23S 23S 2500 T T A Linezolid 15216466 Target modification
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107 23S 23S 2576 G G T Linezolid,Quinupristin+Dalfopristin,Chloramphenicol 18212098 Target modification
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108 # Indels
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109 pbp4_promoter_size_304bp pbp4 promoter -290 - ins ATTTATATGATAGAATATTTCTATTGCATTTTTTGT Cefazolin,Ceftriaxone,Ceftaroline 28373193 Target protection 36 bp duplication (ATTTATATGATAGAATATTTCTATTGCATTTTTTGT) at position -290
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110 rpoB rpoB 475 - ins G Rifampicin 21393177 Target modification rpoB_N474K
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111 rpoB rpoB 475 - ins H Rifampicin 18716806 Target modification |
