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comparison test-data/create/NP_000548.2.hhr @ 0:ad4b7db26523 draft

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"planemo upload commit b68cb41b1884703c4f1574b65a6408d7d0cca321"
author guerler
date Tue, 23 Mar 2021 23:06:45 +0000
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-1:000000000000 0:ad4b7db26523
1 Query NP_000548.2
2 Match_columns 501
3 No_of_seqs 1691 out of 7065
4 Neff 7.55495
5 Searched_HMMs 400
6 Date Sat Jul 25 00:10:29 2020
7 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000548.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000548.2.hhr
8
9 No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM
10 1 5FFO_H Integrin alpha-V, Integ 100.0 2.3E-42 2.1E-46 353.3 0.0 315 143-501 24-363 (363)
11 2 3RJR_C Transforming growth fac 100.0 3.4E-42 3.1E-46 351.8 0.0 315 143-501 24-363 (363)
12 3 5VQF_C Transforming growth fac 100.0 3.4E-42 3.2E-46 351.8 0.0 315 143-501 24-363 (363)
13 4 5NTU_A Growth/differentiation 100.0 9.5E-42 8.8E-46 343.8 0.0 309 142-501 17-335 (335)
14 5 5HLY_A Inhibin beta A chain; G 100.0 3E-39 2.7E-43 332.7 0.0 307 142-501 40-383 (383)
15 6 6SF3_B Serine/threonine-protei 99.8 1.5E-26 1.3E-30 194.7 0.0 105 397-501 4-108 (108)
16 7 4MPL_A Growth/differentiation 99.8 2.3E-26 2E-30 196.3 0.0 106 396-501 10-116 (116)
17 8 6Z3J_B Growth/differentiation 99.8 2.6E-26 2.3E-30 196.2 0.0 107 395-501 11-117 (117)
18 9 5I05_A Growth/differentiation 99.8 4E-26 3.5E-30 192.9 0.0 106 396-501 4-110 (110)
19 10 4N1D_A Bone morphogenetic prot 99.8 4.5E-26 3.9E-30 194.5 0.0 106 396-501 11-116 (116)
20 11 2QCQ_B Bone morphogenetic prot 99.8 5.7E-26 5E-30 191.9 0.0 105 397-501 5-110 (110)
21 12 1LXI_A BONE MORPHOGENETIC PROT 99.8 9E-26 7.8E-30 198.7 0.0 111 391-501 29-139 (139)
22 13 6OMN_G Bone morphogenetic prot 99.8 9.8E-26 8.7E-30 189.8 0.0 105 396-501 4-108 (108)
23 14 2R53_A Bone morphogenetic prot 99.8 9.9E-26 8.7E-30 192.3 0.0 106 396-501 11-116 (116)
24 15 2R53_B Bone morphogenetic prot 99.8 9.9E-26 8.7E-30 192.3 0.0 106 396-501 11-116 (116)
25 16 1REU_A bone morphogenetic prot 99.8 1.1E-25 1E-29 187.7 0.0 102 399-501 2-103 (103)
26 17 1M4U_L Bone Morphogenetic Prot 99.8 1.2E-25 1.1E-29 197.8 0.0 111 391-501 29-139 (139)
27 18 2H62_B Bone morphogenetic prot 99.8 2.1E-25 1.9E-29 189.6 0.0 105 396-501 10-114 (114)
28 19 6Q2J_B Growth/differentiation 99.8 3.8E-25 3.2E-29 193.7 0.0 102 396-501 34-135 (135)
29 20 1KTZ_A TRANSFORMING GROWTH FAC 99.8 7.5E-25 6.6E-29 185.6 0.0 102 395-501 10-112 (112)
30 21 5TY4_B TGF-beta receptor type- 99.8 9.9E-25 8.8E-29 179.9 0.0 96 400-500 1-97 (97)
31 22 5VT2_B Growth/differentiation 99.8 1.1E-24 9.5E-29 184.6 0.0 102 396-501 11-112 (112)
32 23 5VZ3_A Growth/differentiation 99.8 1.1E-24 9.5E-29 184.6 0.0 102 396-501 11-112 (112)
33 24 2ARP_A Inhibin beta A chain, F 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116)
34 25 2ARV_A Inhibin beta A chain; h 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116)
35 26 2P6A_B Activin A, Follistatin 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116)
36 27 2TGI_A TRANSFORMING GROWTH FAC 99.8 1.5E-24 1.3E-28 183.7 0.0 101 396-501 11-112 (112)
37 28 3HH2_B Growth/differentiation 99.8 2.4E-24 2.1E-28 181.5 0.0 99 396-501 11-109 (109)
38 29 5F3B_C RK35 Chimeric antibody 99.8 2.4E-24 2.1E-28 181.5 0.0 99 396-501 11-109 (109)
39 30 3KFD_D Transforming growth fac 99.8 3.7E-24 3.2E-28 181.3 0.0 102 395-501 10-112 (112)
40 31 5E4G_A Growth/differentiation 99.8 1.2E-23 1.1E-27 177.0 0.0 99 396-501 11-109 (109)
41 32 5NMZ_B Neurturin; cystine knot 99.7 2.2E-22 1.9E-26 167.0 0.0 93 397-501 4-101 (101)
42 33 5NMZ_C Neurturin; cystine knot 99.7 2.2E-22 1.9E-26 167.0 0.0 93 397-501 4-101 (101)
43 34 2GH0_C artemin, GDNF family re 99.7 2.9E-22 2.6E-26 166.0 0.0 95 398-501 2-100 (101)
44 35 5MR4_B Neurturin, GDNF family 99.7 4.4E-22 3.9E-26 165.4 0.0 94 396-501 4-102 (102)
45 36 2V5E_B GDNF FAMILY RECEPTOR AL 99.7 7.4E-22 6.6E-26 163.6 0.0 93 397-501 5-101 (101)
46 37 2ASK_B artemin; Glial cell der 99.7 9.1E-22 8E-26 166.6 0.0 94 396-501 12-112 (113)
47 38 3FUB_D GDNF family receptor al 99.7 9.6E-22 8.1E-26 171.2 0.0 96 394-501 35-134 (134)
48 39 1AGQ_C GLIAL CELL-DERIVED NEUR 99.7 2.2E-21 1.8E-25 169.0 0.0 95 395-501 37-135 (135)
49 40 5TX2_A Transforming growth fac 99.7 2.9E-21 2.5E-25 157.7 0.0 81 396-501 12-93 (93)
50 41 5TX4_B TGF-beta receptor type- 99.7 3E-21 2.6E-25 157.3 0.0 81 396-501 11-92 (92)
51 42 2GYZ_A neurotrophic factor art 99.6 1.4E-19 1.2E-23 150.9 0.0 89 399-497 1-97 (105)
52 43 6Q2S_B Ubiquitin-like protein 99.5 2.9E-18 2.5E-22 163.2 0.0 93 397-501 135-234 (235)
53 44 6GFF_E Transforming growth fac 98.9 1.1E-13 1E-17 131.1 0.0 158 143-316 22-193 (249)
54 45 6GFF_G Transforming growth fac 98.9 1.1E-13 1E-17 131.2 0.0 158 143-316 22-193 (249)
55 46 5HLZ_E Inhibin beta A chain; G 98.7 1.8E-12 1.6E-16 124.5 0.0 155 143-317 41-227 (270)
56 47 4YCG_B pro-BMP9 prodomain, hum 98.7 3.5E-12 3.2E-16 124.4 0.0 152 143-316 41-208 (296)
57 48 4YCI_B mouse pro-BMP9 prodomai 98.7 3.5E-12 3.2E-16 124.4 0.0 152 143-316 41-208 (296)
58 49 4NT5_A von Willebrand factor; 75.7 0.27 2.4E-05 38.0 0.0 65 422-501 37-101 (107)
59 50 2KD3_A Sclerostin; Protein, an 73.5 0.35 3E-05 38.0 0.0 73 419-501 39-112 (113)
60 51 4YU8_A Neuroblastoma suppresso 70.0 0.48 4.1E-05 38.5 0.0 88 398-501 32-120 (139)
61 52 2K8P_A Sclerostin; WNT SIGNALL 66.7 0.66 5.3E-05 39.9 0.0 74 419-501 71-144 (189)
62 53 4JPH_D Gremlin-2; Cystine knot 65.1 0.72 6E-05 37.9 0.0 88 398-501 51-138 (148)
63 54 4X1J_B Neuroblastoma suppresso 64.2 0.74 6.5E-05 35.8 0.0 88 398-501 17-105 (116)
64 55 5AEJ_A GREMLIN-1; SIGNALING PR 62.6 0.87 7.2E-05 37.6 0.0 87 397-501 59-147 (152)
65 56 5HK5_G Gremlin-2, Growth/diffe 61.9 0.91 7.6E-05 37.2 0.0 86 398-501 50-137 (147)
66 57 5BPU_A Frizzled-4; Wnt signall 57.8 1.2 0.0001 35.0 0.0 72 422-501 37-108 (122)
67 58 5BQ8_C Norrin; Wnt signalling 54.0 1.5 0.00013 34.3 0.0 93 398-501 16-108 (122)
68 59 5BQE_A Frizzled-4; Wnt signall 54.0 1.5 0.00013 34.3 0.0 93 398-501 16-108 (122)
69
70 No 1
71 >5FFO_H Integrin alpha-V, Integrin beta-6, Transforming; Integrin, TGF-beta, CELL ADHESION; HET: MAN, NAG, BMA; 3.49A {Homo sapiens}
72 Probab=100.00 E-value=2.3e-42 Score=353.27 Aligned_cols=315 Identities=24% Similarity=0.379 Sum_probs=194.7 Template_Neff=9.300
73
74 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----N--SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501)
75 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~--~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501)
76 .+||++|||+++|+.+.. .+.+++++|++||+.+........ . ..+.+.....++++++......... .
77 T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 99 (363)
78 T 5FFO_H 24 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 99 (363)
79 T ss_dssp HHHHHHTTCSSCCCSSSS----CSSCCCHHHHHHHHHHSCCCCC--------CCSSSSCEEEEEEECBCTTSSSTTTTCC
80 T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHHhhccCCCCCCCCCCcccceeeeEEEEEEeecCccccccccc
81 Confidence 689999999999987642 223568999999998765431100 0 0011222234556666533221100 1
82
83
84 Q NP_000548.2 216 VVRKQRYVFDISA----LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501)
85 Q Consensus 216 ~~~~~~l~FnlSs----i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501)
86 ......++|++++ ++. +.|.+|+||||+..... ...|.||..... ....+++++.+.....++
87 T Consensus 100 ~~~~~~~~F~is~~~~~~~~~~~v~~AeLrl~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~~ 167 (363)
88 T 5FFO_H 100 STHSIYMFFQTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-NSWRYLSNRLLAPSDSPE 167 (363)
89 T ss_dssp BTTEEEEEECSTTHHHHSCSGGGEEEEEEECCBCCCCS-----------CCEEEEEEEETT-TEEEEEEEEECCCCSSCC
90 T ss_pred ccceEEEEEechhccccCCCchhhcHhhhHhhcCccCc-----------cEEEEEEEecCc-ccceeeEeEEeCCCCCCC
91 Confidence 2345678999997 433 57999999999887532 345677765421 111233333221234579
92
93
94 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWERG----RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501)
95 Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~----~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501)
96 |+.||||.+|+.|+.++ ++||.|.+.... ....+...++.. .......+|+|++++.+....
97 T Consensus 168 W~~fdVt~~v~~W~~~~~~n~gl~v~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------ 241 (363)
98 T 5FFO_H 168 WLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363)
99 T ss_dssp CCEEECHHHHHHHHHSCCSCEEEEEEECCBTTTTBCCCCCCBSCCTTTCCSSGGGGGGTTCCEEEEEECCTTTC------
100 T ss_pred eEEEEcHHHHHHHHHcCCccccEEEEEEecCCCCCCceeeeeccccCCcccchhhccccCCcEEEEEeCchHHH------
101 Confidence 99999999999999997 788886554311 111110101100 011124566666666432210
102
103
104 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501)
105 Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501)
106 . ..+.+++ ||+. + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++.
107 T Consensus 242 ----~--------~~~~~r~-rr~~---~-~~~~~~~~~~~Cc~~~l~V~F~~~lgw~-~iiaP~~~~a~~C~G~C~~~~ 303 (363)
108 T 5FFO_H 242 ----Q--------HLQSSRH-RRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363)
109 T ss_dssp ----C-------------------------------CCSSSSEEECCCBCHHHHTCCC-SEEECCCBCCCEEECCCCCSC
110 T ss_pred ----H--------hhhHHhh-Hhhc---c-cCCCCCCCcccceeeEEEEEccHHhCCc-eeeCCCeEEeeeccCCCCCcc
111 Confidence 0 0000111 1110 1 1122233467899999999996 99998 999999999999999999997
112
113
114 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
115 Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
116 .. +++|+.++++++...+..++.|||+|++|++|+|||+|++ .++++.++||+|++|||+
117 T Consensus 304 ~~---~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~ily~d~~-~~~~~~~~~m~v~~CgC~ 363 (363)
118 T 5FFO_H 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363)
119 T ss_dssp SC---C-----CCSSCTTTCSSCCSSCCEEECCEEEEEEEECC-C-CCEEEEEEEEEECCEEEC
120 T ss_pred cc---cccHHHHHHHHHhhCCCCCCCCCcccceeceeeEEEEeCC-eeEEEEecCcEEeccCCC
121 Confidence 63 5688988888776555568999999999999999999987 588999999999999995
122
123
124 No 2
125 >3RJR_C Transforming growth factor beta-1; TGF beta, activation, integrin, Cytokine; HET: NAG; 3.05A {Sus scrofa}
126 Probab=100.00 E-value=3.4e-42 Score=351.82 Aligned_cols=315 Identities=24% Similarity=0.389 Sum_probs=198.8 Template_Neff=9.400
127
128 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P 215 (501)
129 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501)
130 .+||++|||+++|+.... .+.+++++|++||+.+........ .. .+.+......+++++......... .
131 T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 99 (363)
132 T 3RJR_C 24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG 99 (363)
133 T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHhhcccccCCcCCCCCCCcccccchhccceEeecCCcccccccCC
134 Confidence 689999999999987641 223568999999997654321100 00 001111122333333221110000 1
135
136
137 Q NP_000548.2 216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501)
138 Q Consensus 216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501)
139 ......+.|+++++ +. +.|.+|+||||+..... ...+.||..... ....++.++.+.....++
140 T Consensus 100 ~~~~~~~~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g 167 (363)
141 T 3RJR_C 100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE 167 (363)
142 T ss_pred CccEEEEEEEcccCCCCCCcchhceEEEEEEEeCCCCC-----------CceEEEEEecCh-hheeEEEEEEeccCCCCc
143 Confidence 13466899999974 22 47999999999887542 235667754321 111233333221234579
144
145
146 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501)
147 Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501)
148 |+.|||+.+|+.|+.++ ++||.|.+... . ..+.+...++.. .......+|+|++++.+....
149 T Consensus 168 W~~fdVt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------ 241 (363)
150 T 3RJR_C 168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363)
151 T ss_pred EEEEECHHHHHHHHhCCcccCcEEEEEEEccCCCCceeeEEEccccCCCcCCcccccccCCCEEEEEEcCCccc------
152 Confidence 99999999999999997 78888655321 1 111111001100 001124566666666432210
153
154
155 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501)
156 Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501)
157 ...+.++ +||+. + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++.
158 T Consensus 242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgW~-wIiaP~~y~a~~C~G~C~~~~ 303 (363)
159 T 3RJR_C 242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363)
160 T ss_pred ------------ccccccc-ccccC---C-CCCCCCCCCCcccceeEEEecchhhCCc-eEecCCeEEeeeecccCCCCC
161 Confidence 0000011 11110 1 1122223467899999999997 99997 999999999999999999997
162
163
164 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
165 Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
166 .. .++|+.++++++...+..++.|||+|++|++|+|||+|++ ++++++++||+|++|||+
167 T Consensus 304 ~~---~t~ha~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~mvv~~CgC~ 363 (363)
168 T 3RJR_C 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363)
169 T ss_pred CC---cCcHHHHHHHHHhcCCCCCCCCcccccccCceEEEEEcCC-cEEEEEeCCeEEeeccCC
170 Confidence 63 5689999988876555578999999999999999999987 588999999999999995
171
172
173 No 3
174 >5VQF_C Transforming growth factor beta-1; pro-complex, latency, homodimer, PROTEIN BINDING; HET: NAG, BMA; 2.9A {Sus scrofa}
175 Probab=100.00 E-value=3.4e-42 Score=351.78 Aligned_cols=315 Identities=24% Similarity=0.389 Sum_probs=197.2 Template_Neff=9.400
176
177 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P 215 (501)
178 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501)
179 .+||++|||+++|++... .+.+++++|++||+.+........ .. .+.+.....++++++......... .
180 T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 99 (363)
181 T 5VQF_C 24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG 99 (363)
182 T ss_dssp HHHHHHTTCSSCCCCTTC----CCSCCCHHHHHHHHHHHCCCBCC-------CCCCSSCEEEEEEECCCSSSSTTTSSTT
183 T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHhhhcCCCCCCCCCCChhhheeeEEEEEEEeecCCceecccCC
184 Confidence 689999999999987641 223568999999997655421100 00 001111122333333221110000 1
185
186
187 Q NP_000548.2 216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501)
188 Q Consensus 216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501)
189 ......+.|+++++ +. +.|.+|+||||+..... ...+.||..... ....++.++.+.....++
190 T Consensus 100 ~~~~~~l~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g 167 (363)
191 T 5VQF_C 100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE 167 (363)
192 T ss_dssp CTTEEEEEEEHHHHHHHCSSGGGEEEEEEEEEECCCSS-----------CEEEEEEEECSS-SCEEEEEEEEECCCSSCE
193 T ss_pred CCCeEEEEEEhhhccccCCCccceeeeEEEEEEcCCcc-----------ceEEEEEEecCc-ccceeEEeEEeCCCCCCC
194 Confidence 13466899999974 22 47999999999887542 245667754321 111233333221234579
195
196
197 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501)
198 Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501)
199 |+.|||+.+|+.|+.++ +++|.|.+... . ..+.+...++.. .......+|+|++++.+....
200 T Consensus 168 W~~fdvt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lvi~~~~~~~~------ 241 (363)
201 T 5VQF_C 168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363)
202 T ss_dssp EEEEECHHHHHHHHHCCCSEEEEEEEECEEEEEETTEEEEEEC------CCCSBCCSSTTCCEEEEEECCSTTT------
203 T ss_pred eEEEEcHHHHHHHHhhchhcCCEEEEEEeecCCCCCceeeEEccccCCCccchhhccccCCcEEEEEEChhHHh------
204 Confidence 99999999999999997 78888655321 1 111111001100 001124566666666432110
205
206
207 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501)
208 Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501)
209 ...+.++ +||+. . ...+.......||+++++|+|+ ||||| |||+|++|+||||.|.|+++.
210 T Consensus 242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgWd-wIiaP~~y~a~~C~G~C~~~~ 303 (363)
211 T 5VQF_C 242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363)
212 T ss_dssp ------------CC---------CE---E-HHHHTTSCCSSSEEECCEEETTTTTCCC-CEEECSEEECCEEECCCCCTT
213 T ss_pred ------------hccchhh-hhhcc---C-cCccCCCCCccceeeEEEEEcchhhCCc-eeeCCCeEEeEeecCCCCCcC
214 Confidence 0000011 11110 1 1122223467899999999997 99997 999999999999999999997
215
216
217 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
218 Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
219 .. .++|+.++++++...+..++.|||+|++|++|+|||+|++ +++++.++||+|++|||+
220 T Consensus 304 ~~---~t~ha~v~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~miv~~CgC~ 363 (363)
221 T 5VQF_C 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363)
222 T ss_dssp TS---CSCCHHHHTGGGGCCGGGSSSCCEEESSEEEEEEEEEETT-EEEEEEEEEEEECEEEEC
223 T ss_pred Cc---cccHHHHHHHHHhcCCCCCCCCCccCcccceeeEEEEECC-eeEEEEecCcEEeccCCC
224 Confidence 63 5689999988876555578999999999999999999987 588999999999999995
225
226
227 No 4
228 >5NTU_A Growth/differentiation factor 8; growth factor, signalling protein, TGFbeta; HET: EDO; 2.58A {Homo sapiens}
229 Probab=100.00 E-value=9.5e-42 Score=343.78 Aligned_cols=309 Identities=22% Similarity=0.402 Sum_probs=196.1 Template_Neff=9.900
230
231 Q NP_000548.2 142 SSFLLKKAREPGPPREPKEPFR-P-PPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRK 219 (501)
232 Q Consensus 142 ~~qIL~kLGL~~~P~~~~~~~~-~-~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~~~~~~ 219 (501)
233 -.+||++|||+++|++....++ . +..+++++|+++|+.+....... ...++++...+++|++|..............
234 T Consensus 17 k~~IL~~LgL~~~P~~~~~~~~~~~~~~~~~~~l~~~y~~~~~~~~~~-~~~~~~~~~~~~~v~~f~~~~~~~~~~~~~~ 95 (335)
235 T 5NTU_A 17 KIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDG-SLEDDDYHATTETIITMPTESDFLMQVDGKP 95 (335)
236 T ss_pred HHHHHHHcCCCCCCCCCCCCCcccCCCCCchHHHHHHHhhccCCCCCC-CCcccchhcccceEEEeccCCCcccCCCCCC
237 Confidence 4689999999999998763110 0 11225799999999765432110 0011223345567888865432210001245
238
239
240 Q NP_000548.2 220 QRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR---QPAALLDVRSVP-GLDGSGWEVF 294 (501)
241 Q Consensus 220 ~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~---~~~~ll~s~~v~-~~~~~gWv~f 294 (501)
242 ..++|+++++.. +.|.+|+||||+...... ....+.||...... .....+....+. ....++|++|
243 T Consensus 96 ~~~~F~ls~~~~~~~v~~AeL~l~~~~~~~~---------~~~~v~vy~v~~~~~~~~~~~~~~~~~~~~~~~~~gW~~f 166 (335)
244 T 5NTU_A 96 KCCFFKFSSKIQYNKVVKAQLWIYLRPVETP---------TTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSI 166 (335)
245 T ss_pred eEEEEECCCCCCCcceeEEEEEEEECCCCCC---------CeEEEEEEEEEccCcCCceeeeeeEEEEEccCCCCcEEEE
246 Confidence 678999997654 589999999999875431 13456666543210 000011111111 1234699999
247
248
249 Q NP_000548.2 295 DIWKLFRNFKNSA--QLCLELEAWERG-RAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYE 371 (501)
250 Q Consensus 295 DVT~aV~~Wl~~~--nlgL~V~~~~~~-~~~~v~~~~~~~~~~~~~~~ppLLv~~~~~~~~~~~~~~~~~~~~~~~~~~~ 371 (501)
251 |||.+|++|+.++ ++||.|.+...+ ....+ .+.... ....+|+|++++.+..
252 T Consensus 167 dVt~~v~~W~~~~~~n~gl~v~~~~~~~~~~~~---~~~~~~-~~~~~P~Lvi~~~~~~--------------------- 221 (335)
253 T 5NTU_A 167 DVKTVLQNWLAAPASNLGIEIKALDENGHDLAV---TFPGPG-EDGLNPFLEVKVTDTP--------------------- 221 (335)
254 T ss_pred EcHHHHHHHHHCCccCceEEEEEEeCCCCeEee---ecCCCC-CcccCcEEEEEecCCC---------------------
255 Confidence 9999999999986 789988775432 11111 111111 1234555555542110
256
257
258 Q NP_000548.2 372 YLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQT 451 (501)
259 Q Consensus 372 ~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~ 451 (501)
260 .++ +|. ....|........||+++++|+|+||||+ |||+|++|+||||.|.|+++.... ++|+.
261 T Consensus 222 ----~~~-~r~----~~~~~~~~~~~~~Ccr~~l~V~F~~igW~-wIiaP~~y~a~~C~G~C~~~~~~~---~~~~~--- 285 (335)
262 T 5NTU_A 222 ----KRS-RRD----FGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLAA---YPHTH--- 285 (335)
263 T ss_pred ----ccc-ccc----CCCCCCCCCCCCCceeeEEEEEHHHcCCc-eeecCCeEEeEeeCccCCCCcccc---CCCch---
264 Confidence 111 111 10123233357899999999999999998 999999999999999999998642 24442
265
266
267 Q NP_000548.2 452 LMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
268 Q Consensus 452 ~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
269 +++...+...+.|||+|++|++|+|||+|++++++++.++||+|++|||+
270 T Consensus 286 ~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~ 335 (335)
271 T 5NTU_A 286 LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 335 (335)
272 T ss_pred hHhccCCCCCCCCcccceeccceEEEEECCCCCEEEEEeCCceeeccccC
273 Confidence 23333333578999999999999999999887889999999999999995
274
275
276 No 5
277 >5HLY_A Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; HET: MSE; 2.302A {Homo sapiens}
278 Probab=100.00 E-value=3e-39 Score=332.69 Aligned_cols=307 Identities=21% Similarity=0.407 Sum_probs=167.2 Template_Neff=8.800
279
280 Q NP_000548.2 142 SSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKG------GN----SSVKLEAGLANTITSFIDKGQD 211 (501)
281 Q Consensus 142 ~~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~------~~----~~~~~~~~~~n~Vrsf~~~~~~ 211 (501)
282 =.+||++|||+++|+++.. . +.+..+..+|+.+....... .+ .+.+.+...++.|+.|....
283 T Consensus 40 K~~IL~kLgL~~~P~~~~~----~--p~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~t~~ii~f~~~~-- 111 (383)
284 T 5HLY_A 40 KKHILNMLHLKKRPDVTQP----V--PKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESG-- 111 (383)
285 T ss_dssp HHHHHHHTTCSSCCCCCCC----S--CHHHHHHHHHHTTSEEECGGGCEEETTCHHHHHHHHHHHHTEEEEEEECEEC--
286 T ss_pred HHHHHHHcCCCCCCCCCCC----C--CCHHHHHHHHHhhcCCCCCCCcccccCCCCCCCCccccccceeEEEEECcCC--
287 Confidence 3689999999999998752 1 11222234565443211000 00 00112223456666665432
288
289
290 Q NP_000548.2 212 DRGPVVRKQRYVFDISALE-K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR----------------- 272 (501)
291 Q Consensus 212 ~~~~~~~~~~l~FnlSsi~-~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~----------------- 272 (501)
292 .....++|++++.+ . +.|.+||||||+....... ......|.||......
293 T Consensus 112 -----~~~~~l~F~iS~~~~~~~~V~~AeL~l~~~~~~~~~------~~~~~~V~vy~~~~~~~~~~~~~~~~~~~~~~~ 180 (383)
294 T 5HLY_A 112 -----TARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKG 180 (383)
295 T ss_dssp -----SSTTEEEEHCCE-------EEEEEEEEEEECS----------------------------------SC----CEC
296 T ss_pred -----CCeEEEEEEcCCCCCCcceeEEEEEEEEecCCCCCC------CCceEEEEEEEEecCCCCCCCCcchhHhhcCCc
297 Confidence 13567899999754 2 4699999999998764320 1124567777543210
298
299
300 Q NP_000548.2 273 -QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWERGR-AVDLRGLGFDRAARQVHEKALFLVFGRT 348 (501)
301 Q Consensus 273 -~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~~-~~~v~~~~~~~~~~~~~~~ppLLv~~~~ 348 (501)
302 ....++.++.+ ....++|++||||.+|+.|+.++ +++|.|.+..... ...+ ...........+|+|++++.+
303 T Consensus 181 ~~~~~l~~s~~i-~~~~~gWi~fdVt~~V~~Wl~~~~~n~gl~v~~~~~~~~~~~l---~~~~~~~~~~~~P~Lvi~~~~ 256 (383)
304 T 5HLY_A 181 ERSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASL---VLLGEEKEQSHRPFLMLQARQ 256 (383)
305 T ss_dssp CEEEEEEEEEEE-ECSSCEEEEEECHHHHHHHHHTTCCEEEEEEECTTTTTTTCEE---ECSCCGGGGGGCCEEEEEEEC
306 T ss_pred ccceEEEEEEEE-eCCCCcEEEEEcHHHHHHHHhCCccCcceEEEEEcCCCCCceE---EEecCCCccccccEEEEEEcC
307 Confidence 00112333333 23457999999999999999987 7888877653221 1101 000011112356666666532
308
309
310 Q NP_000548.2 349 KKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFH 428 (501)
311 Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~y 428 (501)
312 ... . +++++++ . ..| ......||+++++|+|+||||++|||+|++|+|+|
313 T Consensus 257 ~~~----------------------~-~~rr~~~----~-~~~--~~~~~~Cc~~~~~V~F~~lgw~~wIiaP~~y~a~~ 306 (383)
314 T 5HLY_A 257 SED----------------------H-PHRRRRR----G-LEC--DGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANY 306 (383)
315 T ss_dssp C-------------------------------------C-CBC--SSCSSBCEEECCEEETTTTTCTTTEEECSEEECCE
316 T ss_pred ccc----------------------c-ccccccc----C-CCC--CCCCcccccceeeecHHHhCCcceeecCCEEEcee
317 Confidence 110 0 0111111 0 112 12468999999999999999988999999999999
318
319
320 Q NP_000548.2 429 CEGLCEFPLRSHLE--PTNHAVIQTLMNS--MDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
321 Q Consensus 429 C~G~C~~~~~~~~~--~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
322 |.|.|+.+.....+ .++|+.+...+.. ..+...+.|||+|++|++++|||+|++++++++.++||+|++|||+
323 T Consensus 307 C~G~C~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~ 383 (383)
324 T 5HLY_A 307 CEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 383 (383)
325 T ss_dssp EESBCC---------C---SCCC---------------CCCEEEEEEEEEEEEEES-SSCEEEEEEEEEEEEEEEEC
326 T ss_pred ecccCCCCCCCCCCCcccHHHHHHHHHHhcCCCCCcCCCCcccccccCceEEEEEcCCCcEEEEEeCCcEEeecccC
327 Confidence 99999998653211 1235433332211 1123568999999999999999999987889999999999999995
328
329
330 No 6
331 >6SF3_B Serine/threonine-protein kinase receptor R3 (E.C.2.7.11.30); BMP10, ALK1, complex, signalling, TGFbeta; 2.3000067422A {Homo sapiens}
332 Probab=99.85 E-value=1.5e-26 Score=194.74 Aligned_cols=105 Identities=48% Similarity=1.049 Sum_probs=89.1 Template_Neff=8.600
333
334 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI 476 (501)
335 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i 476 (501)
336 ...||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++|
337 T Consensus 4 ~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~i 83 (108)
338 T 6SF3_B 4 GNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISI 83 (108)
339 T ss_dssp -CBSEEECCEEETTTTTGGGTEEECSEEECCEEESBBCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCBCEEEEEEEEEEE
340 T ss_pred CCcceEEEeEeeHHHhCCCceeeCCCceeceeeccccCCCCCCCCCCCchHHHHHHHHhhCccccCCCcccceecCceEE
341 Confidence 56899999999999999988999999999999999999987643334578877776654434467899999999999999
342
343
344 Q NP_000548.2 477 LFIDSANNVVYKQYEDMVVESCGCR 501 (501)
345 Q Consensus 477 ly~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
346 ||+++++.++.+.++||+|++|||+
347 T Consensus 84 l~~~~~~~~~~~~~~~~~v~~C~C~ 108 (108)
348 T 6SF3_B 84 LYLDKGVVTYKFKYEGMAVSECGCR 108 (108)
349 T ss_dssp EEEETTEEEEEEEEEEEEEEEEEEC
350 T ss_pred EEEECCeeEEEEEECCeEEeecccC
351 Confidence 9999875555678999999999995
352
353
354 No 7
355 >4MPL_A Growth/differentiation factor 2; growth factor/cytokine, CYTOKINE; 1.9A {Homo sapiens}
356 Probab=99.84 E-value=2.3e-26 Score=196.32 Aligned_cols=106 Identities=50% Similarity=1.028 Sum_probs=90.4 Template_Neff=7.900
357
358 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
359 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
360 ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++|++++
361 T Consensus 10 ~~~~C~~~~l~V~F~dlgw~~~Ii~P~~~~~~yC~G~C~~~~~~~~~~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 89 (116)
362 T 4MPL_A 10 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 89 (116)
363 T ss_dssp CCCCCEEECCEEETTTTTCTTTEEECSEEECCEEESCCCSSCCTTCCCCHHHHHHHHHHHHSTTTSCCCCEEEEEEEEEE
364 T ss_pred CCCCCEEEEEEEeHHHhCCCCCeeCCCeeEeEEEcccCCCCCCCCCCCCchHHHHHHHhhcCCccCCCCceeeeEecCeE
365 Confidence 35789999999999999998899999999999999999998765333457787777665443446789999999999999
366
367
368 Q NP_000548.2 476 ILFIDSANNVVYK-QYEDMVVESCGCR 501 (501)
369 Q Consensus 476 ily~d~~~~~~~~-~~~~mvv~~CgC~ 501 (501)
370 |||+++++.++++ .++||+|++|+|+
371 T Consensus 90 ily~~~~~~~~~~~~~~~mvv~~CgC~ 116 (116)
372 T 4MPL_A 90 VLYKDDMGVPTLKYHYEGMSVAECGCR 116 (116)
373 T ss_dssp EEEECSSSCEEEEEEEEEEEEEEEEEC
374 T ss_pred EEEECCCCcEEEEEEECCeEEeccccC
375 Confidence 9999988666666 8999999999995
376
377
378 No 8
379 >6Z3J_B Growth/differentiation factor 5, RGM domain; Repulsive Guidance Molecule, RGM, Bone; HET: SO4, GOL, NAG, EDO; 1.65A {Homo sapiens}
380 Probab=99.84 E-value=2.6e-26 Score=196.21 Aligned_cols=107 Identities=98% Similarity=1.618 Sum_probs=92.0 Template_Neff=8.300
381
382 Q NP_000548.2 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501)
383 Q Consensus 395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501)
384 .....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|+++
385 T Consensus 11 ~~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~~cC~P~~~~~l 90 (117)
386 T 6Z3J_B 11 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 90 (117)
387 T ss_dssp -CCCBSEEECCEEETTTTTGGGTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEE
388 T ss_pred CCCCcceeEEEEEeHHHcCCCccEEcCCeeeceeeeecCCCCccccCCCChHHHHHHHHHhcCCCCCCCCcccceeecce
389 Confidence 34789999999999999999889999999999999999999876433345788777766544445678999999999999
390
391
392 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
393 Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
394 +|+|+++++.++++.++||+|++|||+
395 T Consensus 91 ~ily~~~~~~~~~~~~~~~~v~~CgC~ 117 (117)
396 T 6Z3J_B 91 SILFIDSANNVVKKDYEDMVVESCGCR 117 (117)
397 T ss_dssp EEEEECTTSCEEEEEEEEEEEEEEEEC
398 T ss_pred EEEEEcCCCcEEEEEECCeEEeeccCC
399 Confidence 999999877788999999999999995
400
401
402 No 9
403 >5I05_A Growth/differentiation factor 2; GROWTH DIFFERENTIATION FACTOR 2, CELL; HET: GOL; 1.87A {Homo sapiens}
404 Probab=99.84 E-value=4e-26 Score=192.88 Aligned_cols=106 Identities=50% Similarity=1.028 Sum_probs=90.1 Template_Neff=8.400
405
406 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
407 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
408 ....||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++
409 T Consensus 4 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 83 (110)
410 T 5I05_A 4 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 83 (110)
411 T ss_dssp CCCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
412 T ss_pred CCCcceeEEEEEeHHHhCCCCcEeCCCccccEeecCCCCCCCCCCCCCChhHHHHHHHhhcCCCCCCCcccceeeecceE
413 Confidence 35789999999999999998899999999999999999998764333457777776655443456789999999999999
414
415
416 Q NP_000548.2 476 ILFIDSANNVVYK-QYEDMVVESCGCR 501 (501)
417 Q Consensus 476 ily~d~~~~~~~~-~~~~mvv~~CgC~ 501 (501)
418 |||+|++++++++ .++||+|++|||+
419 T Consensus 84 il~~~~~~~~~~~~~~~dm~v~~CgC~ 110 (110)
420 T 5I05_A 84 VLYKDDMGVPTLKYHYEGMSVAECGCR 110 (110)
421 T ss_dssp EEEECTTSCEEEEEEEEEEEEEEEEEC
422 T ss_pred EEEECCCCcEEEEEEeCCeEEeecccC
423 Confidence 9999998766666 8999999999995
424
425
426 No 10
427 >4N1D_A Bone morphogenetic protein 2; Cytokine, Signaling Protein; 1.912A {Homo sapiens}
428 Probab=99.84 E-value=4.5e-26 Score=194.45 Aligned_cols=106 Identities=52% Similarity=1.077 Sum_probs=90.5 Template_Neff=8.300
429
430 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
431 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
432 ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|++++
433 T Consensus 11 ~~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 90 (116)
434 T 4N1D_A 11 LKSSCKRHPLYVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCVPTELSAIS 90 (116)
435 T ss_dssp -C-BSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
436 T ss_pred CCCcceeEEEEEEHHHhCCCCCEeCCCeeeceeeeEeCCCCCccCCCCChhHHHHHHHHhcCCCCCCCCceecceecceE
437 Confidence 46789999999999999998899999999999999999988764333457887777765444446789999999999999
438
439
440 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
441 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
442 |+|+++++.++++.++||+|.+|||+
443 T Consensus 91 il~~~~~~~~~~~~~~~~~v~~C~C~ 116 (116)
444 T 4N1D_A 91 MLYLDENEKVVLKNYQDMVVEGCGCR 116 (116)
445 T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC
446 T ss_pred EEEECCCCcEEEEEeCCeEEeccccC
447 Confidence 99999877788999999999999995
448
449
450 No 11
451 >2QCQ_B Bone morphogenetic protein 3; BMP, TGF-beta, SIGNALING PROTEIN; 2.21A {Homo sapiens}
452 Probab=99.83 E-value=5.7e-26 Score=191.87 Aligned_cols=105 Identities=46% Similarity=1.054 Sum_probs=89.3 Template_Neff=8.500
453
454 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-PESTPPTCCVPTRLSPIS 475 (501)
455 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~-~~~~~~pCC~P~~~~~l~ 475 (501)
456 ...||+++++|+|+||||++|||+|++|+++||.|+|..+.....+.++|+.++.+++... ......|||+|++|++++
457 T Consensus 5 ~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~~CC~P~~~~~l~ 84 (110)
458 T 2QCQ_B 5 PRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLS 84 (110)
459 T ss_dssp CSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHSSCSTTCCCCCEEESSEEEEE
460 T ss_pred CCcceeeEEEEeHHHhCCCcceeCCCeecceeeceeCCCCCCccCCCCcHHHHHHHHHHhCCCCCCCCCceeeEEeCceE
461 Confidence 4689999999999999998899999999999999999998754333457777777655332 134679999999999999
462
463
464 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
465 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
466 |||++++++++++.++||+|++|||+
467 T Consensus 85 il~~~~~~~~~~~~l~~~~v~~CgC~ 110 (110)
468 T 2QCQ_B 85 ILFFDENKNVVLKVYPNMTVESCACR 110 (110)
469 T ss_dssp EEEECTTCCEEEEEEEEEEECCEEEC
470 T ss_pred EEEEcCCCcEEEEEECCeEEeccccC
471 Confidence 99999887788899999999999995
472
473
474 No 12
475 >1LXI_A BONE MORPHOGENETIC PROTEIN 7; Cystine-knot growth factor, HORMONE-GROWTH FACTOR; HET: NAG; 2.0A {Homo sapiens} SCOP: g.17.1.2
476 Probab=99.83 E-value=9e-26 Score=198.70 Aligned_cols=111 Identities=48% Similarity=1.063 Sum_probs=90.2 Template_Neff=7.500
477
478 Q NP_000548.2 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470 (501)
479 Q Consensus 391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~ 470 (501)
480 +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++
481 T Consensus 29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~l~~~~~~~~~~~~CC~P~~ 108 (139)
482 T 1LXI_A 29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ 108 (139)
483 T ss_dssp -------CBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTCCCCCEEEEE
484 T ss_pred cCCccccccceeeeeeccHHHhCCCCceecCCceeeeEecccCCCCcccccCCCHHHHHHHHHHhhCCCCCCCCceeeee
485 Confidence 33445678999999999999999988999999999999999999887543234577777776654434467899999999
486
487
488 Q NP_000548.2 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
489 Q Consensus 471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
490 |++++|||+++++.++++.++||+|++|||+
491 T Consensus 109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~ 139 (139)
492 T 1LXI_A 109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH 139 (139)
493 T ss_dssp EEEEEEEEECTTSCEEEEEEEEEEEEEEEEC
494 T ss_pred eCceEEEEECCCCCEEEEEEcCeEEecccCC
495 Confidence 9999999999877788999999999999995
496
497
498 No 13
499 >6OMN_G Bone morphogenetic protein 2; BMP, Bone Mophogenetic Protein, CYTOKINE; HET: BMA, MAN, NAG; 2.68A {Homo sapiens}
500 Probab=99.83 E-value=9.8e-26 Score=189.80 Aligned_cols=105 Identities=57% Similarity=1.165 Sum_probs=89.4 Template_Neff=8.400
501
502 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
503 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
504 ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++
505 T Consensus 4 ~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~ 82 (108)
506 T 6OMN_G 4 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS 82 (108)
507 T ss_pred CCCCcEEEEeEEehHHcCCCccEECCCeeeeEEEcccCCCCCccccCCCchHHHHHHHhcCC-CCCCCCceeEEeeCceE
508 Confidence 35789999999999999998899999999999999999988654333456777776654432 35689999999999999
509
510
511 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
512 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
513 |||+++++.++++.++||+|++|||+
514 T Consensus 83 ily~~~~~~~~~~~~~~m~v~~CgC~ 108 (108)
515 T 6OMN_G 83 MLYLDENEKVVLKNYQDMVVEGCGCR 108 (108)
516 T ss_pred EEEECCCCcEEEEEeCCeEEeccccC
517 Confidence 99999877788999999999999995
518
519
520 No 14
521 >2R53_A Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens}
522 Probab=99.83 E-value=9.9e-26 Score=192.30 Aligned_cols=106 Identities=49% Similarity=1.068 Sum_probs=89.6 Template_Neff=8.200
523
524 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
525 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
526 ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++
527 T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~ 90 (116)
528 T 2R53_A 11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS 90 (116)
529 T ss_dssp CSSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCTTTTSCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
530 T ss_pred ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE
531 Confidence 36799999999999999998799999999999999999998654323456777666554433345789999999999999
532
533
534 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
535 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
536 |+|+++++.+++++++||+|++|||.
537 T Consensus 91 il~~~~~~~~~~~~l~~~~v~~C~C~ 116 (116)
538 T 2R53_A 91 VLYFDDNSNVILKKYRNMVVRACGCH 116 (116)
539 T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC
540 T ss_pred EEEECCCCcEEEEEEcCeEEecccCC
541 Confidence 99999877788899999999999995
542
543
544 No 15
545 >2R53_B Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens}
546 Probab=99.83 E-value=9.9e-26 Score=192.30 Aligned_cols=106 Identities=49% Similarity=1.068 Sum_probs=89.6 Template_Neff=8.200
547
548 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
549 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
550 ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++
551 T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~ 90 (116)
552 T 2R53_B 11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS 90 (116)
553 T ss_dssp CSSBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
554 T ss_pred ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE
555 Confidence 36799999999999999998799999999999999999998654323456777666554433345789999999999999
556
557
558 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
559 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
560 |+|+++++.+++++++||+|++|||.
561 T Consensus 91 il~~~~~~~~~~~~l~~~~v~~C~C~ 116 (116)
562 T 2R53_B 91 VLYFDDNSNVILKKYRNMVVRACGCH 116 (116)
563 T ss_dssp EEEECTTSCEEEEEEEEEEEEEEEEC
564 T ss_pred EEEECCCCcEEEEEEcCeEEecccCC
565 Confidence 99999877788899999999999995
566
567
568 No 16
569 >1REU_A bone morphogenetic protein 2; TGF-beta fold, HORMONE-GROWTH FACTOR COMPLEX; HET: MPD; 2.65A {Homo sapiens} SCOP: g.17.1.2
570 Probab=99.83 E-value=1.1e-25 Score=187.67 Aligned_cols=102 Identities=56% Similarity=1.151 Sum_probs=87.5 Template_Neff=8.600
571
572 Q NP_000548.2 399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF 478 (501)
573 Q Consensus 399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily 478 (501)
574 .||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++|||
575 T Consensus 2 ~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~~i~~~~~~~~-~~~~~~cC~P~~~~~l~ily 80 (103)
576 T 1REU_A 2 SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPPADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAISMLY 80 (103)
577 T ss_dssp BSEEECCEEETTTTTCTTTCCBCSEEECCEEECBCCSSCCSSSCBCHHHHHHHHHHHHC-SSSCCCCEEEEEEEEEEEEE
578 T ss_pred CceEEEeEecHHHcCCCCcEeCCCeecceEEeeeCCCCCcccCCCChhHHHHHHHhhcC-CCCCCccceeeEeCceEEEE
579 Confidence 69999999999999998899999999999999999998754333456777776654332 35689999999999999999
580
581
582 Q NP_000548.2 479 IDSANNVVYKQYEDMVVESCGCR 501 (501)
583 Q Consensus 479 ~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
584 ++++++++++.++||+|++|||+
585 T Consensus 81 ~~~~~~~~~~~~~~~~v~~CgC~ 103 (103)
586 T 1REU_A 81 LDENEKVVLKNYQDMVVEGCGCR 103 (103)
587 T ss_dssp ECTTCCEEEEEEEEEEEEEEEEC
588 T ss_pred EcCCCcEEEEEeCCeEEeccccC
589 Confidence 99877788999999999999995
590
591
592 No 17
593 >1M4U_L Bone Morphogenetic Protein-7/Noggin; NOGGIN, BMP ANTAGONIST, BMP-7, BONE; HET: NAG; 2.42A {Homo sapiens} SCOP: g.17.1.2
594 Probab=99.82 E-value=1.2e-25 Score=197.81 Aligned_cols=111 Identities=48% Similarity=1.063 Sum_probs=88.2 Template_Neff=7.500
595
596 Q NP_000548.2 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470 (501)
597 Q Consensus 391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~ 470 (501)
598 +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++
599 T Consensus 29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~l~~l~~~~~~~~~~~pCC~P~~ 108 (139)
600 T 1M4U_L 29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ 108 (139)
601 T ss_dssp ---------SEEECCEEESGGGTCTTTEEECSEEECCEEECBCCSSEEGGGCCCHHHHHHHHHHHHCTTSSCCCCEEEEE
602 T ss_pred ccCCCCCCcccceecccCHHHhCCCCceecCCeecceeecccCCCCCccccCCCHHHHHHHHHHhcCCCCCCCCceeeee
603 Confidence 33445678999999999999999988999999999999999999887533234577777776654434467899999999
604
605
606 Q NP_000548.2 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
607 Q Consensus 471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
608 |++++|||+++++.++++.++||+|++|||+
609 T Consensus 109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~ 139 (139)
610 T 1M4U_L 109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH 139 (139)
611 T ss_dssp EEEEEEEEECTTSCEEEEEEEEEEEEEEEES
612 T ss_pred cCCeEEEEECCCCCEEEEEECCeEEeccccC
613 Confidence 9999999999877788999999999999995
614
615
616 No 18
617 >2H62_B Bone morphogenetic protein 2, Bone; TGF-beta superfamily, ligand-receptor complex, HORMONE-GROWTH; 1.85A {Homo sapiens} SCOP: g.17.1.2
618 Probab=99.82 E-value=2.1e-25 Score=189.59 Aligned_cols=105 Identities=57% Similarity=1.165 Sum_probs=88.7 Template_Neff=8.300
619
620 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
621 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
622 ....||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... .....|||+|++|++++
623 T Consensus 10 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~ 88 (114)
624 T 2H62_B 10 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS 88 (114)
625 T ss_dssp --CBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHHC-TTSCCCCEEEEEEEEEE
626 T ss_pred ccCcceEEEEEEehHHcCCCCcEeCCCeeeceEEeeeCCCCCccccCCCchHHHHHHHHhcC-CCCCCccceeeEeCceE
627 Confidence 46789999999999999998899999999999999999988754333456777776654332 35689999999999999
628
629
630 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
631 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
632 |+|+|++++++++.++||+|++|+|+
633 T Consensus 89 ily~~~~~~~~~~~~~~~~v~~C~C~ 114 (114)
634 T 2H62_B 89 MLYLDENEKVVLKNYQDMVVEGCGCR 114 (114)
635 T ss_dssp EEEEETTTEEEEEEEEEEEEEEEEEC
636 T ss_pred EEEECCCCcEEEEEeCCeEEeccccC
637 Confidence 99999877788999999999999995
638
639
640 No 19
641 >6Q2J_B Growth/differentiation factor 15, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 4.1A {Homo sapiens}
642 Probab=99.81 E-value=3.8e-25 Score=193.68 Aligned_cols=102 Identities=27% Similarity=0.754 Sum_probs=85.9 Template_Neff=7.400
643
644 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
645 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
646 ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+..+..|||+|++|++++
647 T Consensus 34 ~~~cC~~~~~~V~F~dlGw~~wIi~P~~~~~~~C~G~C~~~~~~---~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 110 (135)
648 T 6Q2J_B 34 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 110 (135)
649 T ss_pred CcCcceeEEEEEeHHHcCCCCcEECCCeEEeEEecccCCCCCCC---CChHHHHHHHHHhcCCCCCCCCceeeeeecceE
650 Confidence 34445458999999999997799999999999999999988753 346777777665444456789999999999999
651
652
653 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
654 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
655 |+|++++ .++++.++||+|++|||+
656 T Consensus 111 ily~~~~-~i~~~~l~dmvv~~CgC~ 135 (135)
657 T 6Q2J_B 111 LIQKTDT-GVSLQTYDDLLAKDCHCI 135 (135)
658 T ss_pred EEEECCC-eEEEEEECCeEEeccccC
659 Confidence 9998874 788899999999999995
660
661
662 No 20
663 >1KTZ_A TRANSFORMING GROWTH FACTOR BETA 3/TGF-beta; CYTOKINE-RECEPTOR COMPLEX, CYTOKINE-CYTOKINE RECEPTOR COMPLEX; 2.15A {Homo sapiens} SCOP: g.17.1.2
664 Probab=99.80 E-value=7.5e-25 Score=185.60 Aligned_cols=102 Identities=35% Similarity=0.837 Sum_probs=76.2 Template_Neff=8.200
665
666 Q NP_000548.2 395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP 473 (501)
667 Q Consensus 395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~ 473 (501)
668 .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+...+.|||+|++|++
669 T Consensus 10 ~~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~ 85 (112)
670 T 1KTZ_A 10 NLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEP 85 (112)
671 T ss_dssp ---CCCEEECCEEECCCCCCCC-CEEECSEEECCEEECCCCSSCCC---------------------CCCCCEEECCEEE
672 T ss_pred cccCCcEEEEEEEECchhcCCC-eeeCCCeeeeeeeeecCCCCCCC---CCChHHHHHHHHhcCcccCCCCcccceecCc
673 Confidence 3478999999999999 99998 99999999999999999998753 3578877776654444567899999999999
674
675
676 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
677 Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
678 ++|||++++ .++++.++||+|++|||+
679 T Consensus 86 l~ily~~~~-~~~~~~~~~miv~~CgC~ 112 (112)
680 T 1KTZ_A 86 LTILYYVGR-TPKVEQLSNMVVKSCKCS 112 (112)
681 T ss_dssp EEEEEEETT-EEEEEEEEEEEECCEEEC
682 T ss_pred eEEEEEeCC-eeEEEEecCeEEeeCcCC
683 Confidence 999999987 577899999999999995
684
685
686 No 21
687 >5TY4_B TGF-beta receptor type-2 (E.C. 2.7.11.30); TRANSFERASE; 2.9A {Homo sapiens}
688 Probab=99.80 E-value=9.9e-25 Score=179.89 Aligned_cols=96 Identities=34% Similarity=0.853 Sum_probs=84.4 Template_Neff=8.500
689
690 Q NP_000548.2 400 CSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF 478 (501)
691 Q Consensus 400 Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily 478 (501)
692 ||+++++|+|+ ++||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++|+|
693 T Consensus 1 Cc~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~il~ 76 (97)
694 T 5TY4_B 1 CCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIVY 76 (97)
695 T ss_pred CeEEEEEEECccccCCC-ceeCCCcccCeeeceeCCCCCCC---CccHHHHHHHHHhcCcccCCCCceeceeccceeEEE
696 Confidence 89999999997 99998 99999999999999999988653 457888777765444445789999999999999999
697
698
699 Q NP_000548.2 479 IDSANNVVYKQYEDMVVESCGC 500 (501)
700 Q Consensus 479 ~d~~~~~~~~~~~~mvv~~CgC 500 (501)
701 ++++ +++++.++||+|++|||
702 T Consensus 77 ~~~~-~~~~~~~~~m~v~~CgC 97 (97)
703 T 5TY4_B 77 YVGR-KPKVEQLSNMIVKSCKC 97 (97)
704 T ss_pred EeCC-ceEEEEecCeEEeeCCC
705 Confidence 9987 57889999999999999
706
707
708 No 22
709 >5VT2_B Growth/differentiation factor 15; TGF-beta family, SIGNALING PROTEIN; HET: EDO; 2.3A {Homo sapiens}
710 Probab=99.80 E-value=1.1e-24 Score=184.58 Aligned_cols=102 Identities=27% Similarity=0.753 Sum_probs=87.2 Template_Neff=8.300
711
712 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
713 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
714 ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++
715 T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 87 (112)
716 T 5VT2_B 11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 87 (112)
717 T ss_dssp TTCBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
718 T ss_pred CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE
719 Confidence 34455569999999999998899999999999999999998753 457888877765544556789999999999999
720
721
722 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
723 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
724 |+|+++ +.+++++++||+|++|||.
725 T Consensus 88 il~~~~-~~~~~~~~~~m~v~~C~C~ 112 (112)
726 T 5VT2_B 88 LIQKTD-TGVSLQTYDDLLAKDCHCI 112 (112)
727 T ss_dssp EEEECS-SSEEEEEEEEEEEEEEEEC
728 T ss_pred EEEEcC-CeEEEEEeCCeEEecCCcC
729 Confidence 999887 4788999999999999995
730
731
732 No 23
733 >5VZ3_A Growth/differentiation factor 15; Growth Factor, SIGNALING PROTEIN; 1.97A {Homo sapiens}
734 Probab=99.80 E-value=1.1e-24 Score=184.58 Aligned_cols=102 Identities=27% Similarity=0.753 Sum_probs=87.2 Template_Neff=8.300
735
736 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
737 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
738 ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++
739 T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 87 (112)
740 T 5VZ3_A 11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 87 (112)
741 T ss_dssp SSSBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
742 T ss_pred CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE
743 Confidence 34455569999999999998899999999999999999998753 457888877765544556789999999999999
744
745
746 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
747 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
748 |+|+++ +.+++++++||+|++|||.
749 T Consensus 88 il~~~~-~~~~~~~~~~m~v~~C~C~ 112 (112)
750 T 5VZ3_A 88 LIQKTD-TGVSLQTYDDLLAKDCHCI 112 (112)
751 T ss_dssp EEEECS-SSEEEEEEEEEEEEEEEEC
752 T ss_pred EEEEcC-CeEEEEEeCCeEEecCCcC
753 Confidence 999887 4788999999999999995
754
755
756 No 24
757 >2ARP_A Inhibin beta A chain, Follistatin; cystine knot, disulfide rich, egf; HET: GOL, 1PG; 2.0A {Homo sapiens} SCOP: g.17.1.2
758 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=81.5 Template_Neff=8.700
759
760 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501)
761 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501)
762 ...||++.++|+|++|||++|||+|++|+++||.|.|..+..... ..++|+.++.++.. ..+.....|||+|++|+
763 T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116)
764 T 2ARP_A 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116)
765 T ss_dssp -CCSEEECCEEEHHHHTCTTTEEECSEEECCEEESCCCC-CCHHH----H----HHHHTTSTTCSSCCCCCCCEEEEEEE
766 T ss_pred cccceeEEEEEeHHHcCCccceeCCCceeCceeeeeCCCCcCcCCCCCcchHHHHHHHHHhhCCCCCcCCCCcccccccC
767 Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999
768
769
770 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
771 Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
772 +++|+|++++++++++.++||+|++|||+
773 T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116)
774 T 2ARP_A 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116)
775 T ss_dssp EEEEEEEC-TTCEEEEEEEEEEEEEEEEC
776 T ss_pred ceEEEEEcCCCcEEEEEeCCeEEeecccC
777 Confidence 99999999877788999999999999995
778
779
780 No 25
781 >2ARV_A Inhibin beta A chain; homodimer, cystine knot, disulfide linked; HET: 1PG, SO4, GOL; 2.0A {Homo sapiens} SCOP: g.17.1.2
782 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=86.7 Template_Neff=8.700
783
784 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501)
785 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501)
786 ...||++.++|+|++|||++|||+|++|+++||.|.|+.+..... +.++|+.++.++.. ..+.....|||+|++|+
787 T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116)
788 T 2ARV_A 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116)
789 T ss_dssp CCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCGGGTTEETTEECHHHHHHHHHHHTTCTTTTTSCCCEEEEEEE
790 T ss_pred cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec
791 Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999
792
793
794 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
795 Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
796 +++|||++++++++++.++||+|++|||+
797 T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116)
798 T 2ARV_A 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116)
799 T ss_dssp EEEEEEEETTTEEEEEEEEEEEEEEEEEC
800 T ss_pred cEEEEEEeCCCeEEEEEeCCeEEeeccCC
801 Confidence 99999999877788999999999999995
802
803
804 No 26
805 >2P6A_B Activin A, Follistatin 315; Follistatin, Activin,Inhibin, TGF-beta, SIGNALING PROTEIN; 3.4A {Homo sapiens} SCOP: g.17.1.2
806 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=86.7 Template_Neff=8.700
807
808 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501)
809 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501)
810 ...||++.++|+|++|||++|||+|++|+++||.|.|+.+..... +.++|+.++.++.. ..+.....|||+|++|+
811 T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116)
812 T 2P6A_B 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116)
813 T ss_pred cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec
814 Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999
815
816
817 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
818 Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
819 +++|||++++++++++.++||+|++|||+
820 T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116)
821 T 2P6A_B 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116)
822 T ss_pred cEEEEEEeCCCeEEEEEeCCeEEeeccCC
823 Confidence 99999999877788999999999999995
824
825
826 No 27
827 >2TGI_A TRANSFORMING GROWTH FACTOR-BETA TWO (TGF-B2); GROWTH FACTOR; 1.8A {Homo sapiens} SCOP: g.17.1.2
828 Probab=99.79 E-value=1.5e-24 Score=183.69 Aligned_cols=101 Identities=35% Similarity=0.828 Sum_probs=88.1 Template_Neff=8.200
829
830 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501)
831 Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501)
832 ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|+++
833 T Consensus 11 ~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l 86 (112)
834 T 2TGI_A 11 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPL 86 (112)
835 T ss_dssp CCSBSEEECCEEECCCCCCCT-TEEECSEEECCEEECBCCTTSSB---CSHHHHHHHHHHHHCGGGCCCCCEEECSEEEE
836 T ss_pred CCCCcEEEEEEEECchhhCCc-eeeCCCeEeceeecccCCCCCCC---cccHHHHHHHHHhcCcccCCCCceeceeecce
837 Confidence 478999999999999 99998 99999999999999999988653 34677777766544444678999999999999
838
839
840 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
841 Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
842 +|||++++ +++++.++||+|++|||+
843 T Consensus 87 ~il~~~~~-~~~~~~~~~m~v~~CgC~ 112 (112)
844 T 2TGI_A 87 TILYYIGK-TPKIEQLSNMIVKSCKCS 112 (112)
845 T ss_dssp EEEEEETT-EEEEEEEEEEEECCEEEC
846 T ss_pred EEEEEeCC-ceEEEEeCCeEEEeCCCC
847 Confidence 99999986 578899999999999995
848
849
850 No 28
851 >3HH2_B Growth/differentiation factor 8, Follistatin; protein-protein complex, TB domain, cystine; HET: PO4, CIT; 2.15A {Mus musculus}
852 Probab=99.79 E-value=2.4e-24 Score=181.50 Aligned_cols=99 Identities=39% Similarity=0.949 Sum_probs=82.7 Template_Neff=8.200
853
854 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
855 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
856 ....||+++++|+|++|||+ |||+|++|+++||.|.|..+.... .+|+. +++...+.....|||+|++|++++
857 T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~ 83 (109)
858 T 3HH2_B 11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN 83 (109)
859 T ss_dssp CCCBSEEECCEEEHHHHTCT-TEEECSEEECCEEECBCCTTTTBC---CHHHH---HHHHHCCTTCCCCCEEEEEEEEEE
860 T ss_pred CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE
861 Confidence 46799999999999999998 999999999999999999987542 13332 222222235689999999999999
862
863
864 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
865 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
866 |+|++++++++++.++||+|++|||+
867 T Consensus 84 il~~~~~~~~~~~~~~~m~v~~CgC~ 109 (109)
868 T 3HH2_B 84 MLYFNGKEQIIYGKIPAMVVDRCGCS 109 (109)
869 T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC
870 T ss_pred EEEEcCCCeEEEEEeCCeEEecccCC
871 Confidence 99999877788999999999999995
872
873
874 No 29
875 >5F3B_C RK35 Chimeric antibody heavy chain; myostatin, antibody, complex, Signaling Protein-Immune; HET: GOL; 1.76A {Mus musculus}
876 Probab=99.79 E-value=2.4e-24 Score=181.50 Aligned_cols=99 Identities=39% Similarity=0.949 Sum_probs=82.7 Template_Neff=8.200
877
878 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
879 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
880 ....||+++++|+|++|||+ |||+|++|+++||.|.|..+.... .+|+. +++...+.....|||+|++|++++
881 T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~ 83 (109)
882 T 5F3B_C 11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN 83 (109)
883 T ss_pred CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE
884 Confidence 46799999999999999998 999999999999999999987542 13332 222222235689999999999999
885
886
887 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
888 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
889 |+|++++++++++.++||+|++|||+
890 T Consensus 84 il~~~~~~~~~~~~~~~m~v~~CgC~ 109 (109)
891 T 5F3B_C 84 MLYFNGKEQIIYGKIPAMVVDRCGCS 109 (109)
892 T ss_pred EEEEcCCCeEEEEEeCCeEEecccCC
893 Confidence 99999877788999999999999995
894
895
896 No 30
897 >3KFD_D Transforming growth factor beta-1, TGF-beta; TGF-beta, TGF-b1, TGF-beta receptor type-1; 2.995A {Homo sapiens}
898 Probab=99.78 E-value=3.7e-24 Score=181.25 Aligned_cols=102 Identities=30% Similarity=0.731 Sum_probs=87.9 Template_Neff=8.300
899
900 Q NP_000548.2 395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP 473 (501)
901 Q Consensus 395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~ 473 (501)
902 .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+..+..|||+|++|++
903 T Consensus 10 ~~~~~C~~~~~~v~f~~~lg~~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~~~~~~~~~~~~~~~~~~~~CC~P~~~~~ 85 (112)
904 T 3KFD_D 10 STEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWSL---DTQYSKVLALYNQHNPGASAAPCCVPQALEP 85 (112)
905 T ss_pred CCCCCcEEEEEEEECccccCCc-eeeCCCeEEeeeeceeCCCCCCC---cccHHHHHHHHHhhCCCCCCCCccccccccc
906 Confidence 3477899999999998 99998 99999999999999999988653 3467777766654444467899999999999
907
908
909 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
910 Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
911 ++|+|++++ +++++.++||+|++|||+
912 T Consensus 86 l~ily~~~~-~~~~~~~~~m~v~~CgC~ 112 (112)
913 T 3KFD_D 86 LPIVYYVGR-KPKVEQLSNMIVRSCKCS 112 (112)
914 T ss_pred eeEEEEeCC-eEEEEEeCCeEEEecCCC
915 Confidence 999999987 577899999999999995
916
917
918 No 31
919 >5E4G_A Growth/differentiation factor 11; Bone morphogenetic protein 11, BMP-11; HET: PG4; 1.5A {Homo sapiens}
920 Probab=99.76 E-value=1.2e-23 Score=177.01 Aligned_cols=99 Identities=37% Similarity=0.939 Sum_probs=83.0 Template_Neff=8.400
921
922 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501)
923 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501)
924 ....||+++++|+|+||||+ |||+|++|+++||.|+|..+.... .+|+.+ +....+..++.|||+|++|++++
925 T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~l---~~~~~~~~~~~~cC~P~~~~~l~ 83 (109)
926 T 5E4G_A 11 SESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQK---YPHTHL---VQQANPRGSAGPCCTPTKMSPIN 83 (109)
927 T ss_dssp CCCBSEEECCEEETTTTTCT-TEEECSEEECCEEECBCCTTTTCS---STHHHH---HHHHCCTTCCCCCEEEEEEEEEE
928 T ss_pred CcCceEeEEEEEehHHcCCc-eEeCCCeeeceeecccCCcccccc---CCchHH---HHhcCCCCCCCCCccceeeccEE
929 Confidence 47799999999999999998 999999999999999999987532 133322 11122345789999999999999
930
931
932 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
933 Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
934 |+|++++++++++.++||+|++|||+
935 T Consensus 84 il~~~~~~~~~~~~~~d~~v~~C~C~ 109 (109)
936 T 5E4G_A 84 MLYFNDKQQIIYGKIPGMVVDRCGCS 109 (109)
937 T ss_dssp EEEECSSSCEEEEEEEEEEEEEEEEC
938 T ss_pred EEEEcCCCeEEEEEeCCeEEeeccCC
939 Confidence 99999887888999999999999995
940
941
942 No 32
943 >5NMZ_B Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens}
944 Probab=99.71 E-value=2.2e-22 Score=166.98 Aligned_cols=93 Identities=22% Similarity=0.465 Sum_probs=76.9 Template_Neff=8.300
945
946 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS 472 (501)
947 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~ 472 (501)
948 ...||+++++|+|+||||+ | |+|++|+++||.|.|..+.. +| +.++.+++... +.....|||+|++|+
949 T Consensus 4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~ 75 (101)
950 T 5NMZ_B 4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE 75 (101)
951 T ss_dssp CCBSEEEEEEEEGGGGTSS-C-CCCCEEEEEEEECBCGGGCC------HHHHHHHHHHTTTCSTTCCBCCSCCEEEEEEC
952 T ss_pred CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec
953 Confidence 5689999999999999999 8 89999999999999999864 23 33444433322 246789999999999
954
955
956 Q NP_000548.2 473 -PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
957 Q Consensus 473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
958 +++ |+|++ ++++.++||+|++|||+
959 T Consensus 76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101)
960 T 5NMZ_B 76 DEVS--FLDAH--SRYHTVHELSARECACV 101 (101)
961 T ss_dssp SEEE--EECTT--CCEEEEESCSEEEEEEC
962 T ss_pred CceE--eecCC--cEEEEeCCeeeecccCC
963 Confidence 999 77764 78899999999999995
964
965
966 No 33
967 >5NMZ_C Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens}
968 Probab=99.71 E-value=2.2e-22 Score=166.98 Aligned_cols=93 Identities=22% Similarity=0.465 Sum_probs=76.9 Template_Neff=8.300
969
970 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS 472 (501)
971 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~ 472 (501)
972 ...||+++++|+|+||||+ | |+|++|+++||.|.|..+.. +| +.++.+++... +.....|||+|++|+
973 T Consensus 4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~ 75 (101)
974 T 5NMZ_C 4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE 75 (101)
975 T ss_dssp CCBSEEEEEEEEGGGGTSS-S-CCCCEEEEEEEECBCCTTSC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEEC
976 T ss_pred CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec
977 Confidence 5689999999999999999 8 89999999999999999864 23 33444433322 246789999999999
978
979
980 Q NP_000548.2 473 -PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
981 Q Consensus 473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
982 +++ |+|++ ++++.++||+|++|||+
983 T Consensus 76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101)
984 T 5NMZ_C 76 DEVS--FLDAH--SRYHTVHELSARECACV 101 (101)
985 T ss_dssp SCEE--EECTT--SCEEEESSCSEEEEEEC
986 T ss_pred CceE--eecCC--cEEEEeCCeeeecccCC
987 Confidence 999 77764 78899999999999995
988
989
990 No 34
991 >2GH0_C artemin, GDNF family receptor alpha-3; cystine-knot, helix bundle, HORMONE-GROWTH FACTOR; HET: BMA, NAG, MAN; 1.92A {Homo sapiens}
992 Probab=99.71 E-value=2.9e-22 Score=166.00 Aligned_cols=95 Identities=19% Similarity=0.418 Sum_probs=77.9 Template_Neff=8.600
993
994 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD----PESTPPTCCVPTRLSP 473 (501)
995 Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~----~~~~~~pCC~P~~~~~ 473 (501)
996 ..||+++++|+|+||||++||| ++|+++||.|.|+.+.... .+.|+.++.++ ... ....+.|||+|++|++
997 T Consensus 2 ~~C~~~~~~V~f~dlgw~~~I~--~~~~~~~C~G~C~~~~~~~--~~~~~~l~~~~-~~~~~~~~~~~~~~CC~P~~~~~ 76 (101)
998 T 2GH0_C 2 PGCRLRSQLVPVRALGLGHRSD--ELVRFRFCSGSCRRARSPH--DLSLASLLGAG-ALRPPPGSRPVSQPCCRPTRYEA 76 (101)
999 T ss_pred CCCcceEEEEeHHHcCCCcccC--cEEecceeeeeCCCCCCCc--cchHHHHHHcc-cCCCCCCCCCCCCCceeeeeecc
1000 Confidence 4799999999999999988988 9999999999999987642 23455554443 111 1357899999999999
1001
1002
1003 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1004 Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1005 ++|||+++ +++.++||+|++|||+
1006 T Consensus 77 l~il~~~~----~~~~~~~m~v~~CgC~ 100 (101)
1007 T 2GH0_C 77 VSFMDVNS----TWRTVDRLSATACGCL 100 (101)
1008 T ss_pred eEEEEeCC----eeEEEcceEeeccccc
1009 Confidence 99999875 5789999999999995
1010
1011
1012 No 35
1013 >5MR4_B Neurturin, GDNF family receptor alpha-2; Complex, Signalling, Receptor, signaling protein; 2.4A {Homo sapiens}
1014 Probab=99.70 E-value=4.4e-22 Score=165.39 Aligned_cols=94 Identities=21% Similarity=0.445 Sum_probs=76.5 Template_Neff=8.200
1015
1016 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRL 471 (501)
1017 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~ 471 (501)
1018 ....||+++++|+|+||||+ | |+|++|+++||.|.|+.+.. +| +.++.++.... +.....|||+|++|
1019 T Consensus 4 ~~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~CC~P~~~ 75 (102)
1020 T 5MR4_B 4 GARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAY 75 (102)
1021 T ss_dssp -CCBSEEEEEEEEGGGGSSS-C-CCCCEEEEEEEESBCCSCCC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEE
1022 T ss_pred CCCCceeeEEEEEHHHcCCc-e-eCCCeEECeeeceeCCchhc------chHHHHHHHHHhhhhhccccCCCCceeeeee
1023 Confidence 35789999999999999998 7 89999999999999999864 23 33333333222 24678999999999
1024
1025
1026 Q NP_000548.2 472 S-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1027 Q Consensus 472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1028 + +++ |+|++ ++++.++||+|++|||+
1029 T Consensus 76 ~~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 102 (102)
1030 T 5MR4_B 76 EDEVS--FLDAH--SRYHTVHELSARECACV 102 (102)
1031 T ss_dssp CCEEE--EECTT--SCEEEEESCSEEEEEEC
1032 T ss_pred cCceE--eecCC--cEEEEECCeeeccccCC
1033 Confidence 9 999 77764 78999999999999995
1034
1035
1036 No 36
1037 >2V5E_B GDNF FAMILY RECEPTOR ALPHA-1, GLIAL; RECEPTOR-GLYCOPROTEIN COMPLEX, CELL MEMBRANE, GROWTH; HET: NAG, EDO, SCR; 2.35A {RATTUS NORVEGICUS}
1038 Probab=99.69 E-value=7.4e-22 Score=163.65 Aligned_cols=93 Identities=24% Similarity=0.547 Sum_probs=77.2 Template_Neff=8.400
1039
1040 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRLS- 472 (501)
1041 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~~- 472 (501)
1042 ...||+++++|+|+||||+ | |+|++|+++||.|.|+.+.. +| +.++.+++... +..+..|||+|++|+
1043 T Consensus 5 ~~~C~~~~~~V~f~~lgw~-~-i~P~~~~~~~C~G~C~~~~~------~h~~~~~~l~~~~~~~~~~~~~~CC~P~~~~~ 76 (101)
1044 T 2V5E_B 5 NRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAET------TYDKILKNLSRNRRLVSDKVGQACCRPIAFDD 76 (101)
1045 T ss_dssp TTTCEEEEEEEEGGGGCSS-C-CCSCEEEEEEEESCCCSCCS------HHHHHHHHHHHTTSSSSSSTTCCCEEEEEECC
1046 T ss_pred CCcceeeEEEEEHHHcCCc-c-cCCCeEECceecEeCCCCCC------cHHHHHHHHHhccCCCcccCCCCeEEeeEecC
1047 Confidence 5689999999999999998 7 89999999999999999842 45 44554443321 345789999999999
1048
1049
1050 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1051 Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1052 +++ |+|++ ++++.++||+|++|||+
1053 T Consensus 77 ~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101)
1054 T 2V5E_B 77 DLS--FLDDN--LVYHILRKHSAKRCGCI 101 (101)
1055 T ss_dssp CEE--EECTT--SCEEEECSCSEEEEEEC
1056 T ss_pred ceE--EecCC--EEEEEecCcEecccccC
1057 Confidence 999 77775 57899999999999995
1058
1059
1060 No 37
1061 >2ASK_B artemin; Glial cell derived family ligand; HET: SO4; 1.55A {Homo sapiens}
1062 Probab=99.69 E-value=9.1e-22 Score=166.60 Aligned_cols=94 Identities=20% Similarity=0.467 Sum_probs=77.2 Template_Neff=8.000
1063
1064 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVP 468 (501)
1065 Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P 468 (501)
1066 ....||+++++|+|+||||+ | |+|++|+++||.|.|..+. ++| +.++.+++... ......|||+|
1067 T Consensus 12 ~~~~Cc~~~~~V~F~dlgw~-~-i~P~~~~~~~C~G~C~~~~------~~h~~~~~~l~~~~~~~~~~~~~~~~~~CC~P 83 (113)
1068 T 2ASK_B 12 GARGCRLRSQLVPVRALGLG-H-RSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRP 83 (113)
1069 T ss_dssp -CCBSEEEEEEEEGGGGSSS-C-CBSSEEEEEEEECBCGGGC------CHHHHHHHHHHHTTCSCCCSSSCCCCSCEEEE
1070 T ss_pred CCCCceeEEEEEEHHHcCCC-c-cCCCeEECceEeeeCCCCC------CCcHHHHHHHHHccCCCCCCCCCCCCCCceee
1071 Confidence 46799999999999999998 6 7999999999999999983 245 45555554332 23578999999
1072
1073
1074 Q NP_000548.2 469 TRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1075 Q Consensus 469 ~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1076 ++|++++ |+|++ +++++++||+|++|||.
1077 T Consensus 84 ~~~~~l~--y~d~~--~~~~~l~~miv~~CgC~ 112 (113)
1078 T 2ASK_B 84 TRYEAVS--FMDVN--STWRTVDRLSATACGCL 112 (113)
1079 T ss_dssp EEEEEEE--EEBTT--SCEEEEEEEEEEEEEEE
1080 T ss_pred eEeceee--eecCC--cEEEEECCeEEeccccc
1081 Confidence 9999877 77775 67899999999999995
1082
1083
1084 No 38
1085 >3FUB_D GDNF family receptor alpha-1, Glial; GFRALPHA1, ALL ALPHA GDNF, CYSTINE; HET: NAG, EDO; 2.35A {Rattus norvegicus}
1086 Probab=99.69 E-value=9.6e-22 Score=171.18 Aligned_cols=96 Identities=24% Similarity=0.517 Sum_probs=80.0 Template_Neff=6.800
1087
1088 Q NP_000548.2 394 KNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSM--DPESTPPTCCVPTR 470 (501)
1089 Q Consensus 394 ~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~--~~~~~~~pCC~P~~ 470 (501)
1090 ......||++.++|+|+||||+ | |+|++|+++||.|.|.++. ++| ++++.+++.. .+..+..|||+|++
1091 T Consensus 35 ~~~~~~Ccr~~l~V~F~dlGw~-~-iaP~~f~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~ 106 (134)
1092 T 3FUB_D 35 RGKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAE------TTYDKILKNLSRNRRLVSDKVGQACCRPIA 106 (134)
1093 T ss_pred CCCCCcceEEEEEEeHHHcCCC-c-cCCCeEEeEEeeCCCCCCc------chHHHHHHHHHHcCCCCCCCCCCCeeeeeE
1094 Confidence 3457899999999999999998 6 5999999999999999982 356 5666665543 12357899999999
1095
1096
1097 Q NP_000548.2 471 LS-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1098 Q Consensus 471 ~~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1099 |+ +++ |++++ + ++++++||+|++|||.
1100 T Consensus 107 ~~~~l~--y~d~~-~-~~~~l~~mvv~~CgC~ 134 (134)
1101 T 3FUB_D 107 FDDDLS--FLDDN-L-VYHILRKHSAKRCGCI 134 (134)
1102 T ss_pred eCCcee--EECCC-c-eEEEEcCeEEecccCC
1103 Confidence 99 988 77776 4 7899999999999995
1104
1105
1106 No 39
1107 >1AGQ_C GLIAL CELL-DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR, NEUROTROPHIC FACTOR, CYSTINE; 1.9A {Rattus norvegicus} SCOP: g.17.1.2
1108 Probab=99.67 E-value=2.2e-21 Score=169.01 Aligned_cols=95 Identities=26% Similarity=0.544 Sum_probs=76.0 Template_Neff=6.700
1109
1110 Q NP_000548.2 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRL 471 (501)
1111 Q Consensus 395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~ 471 (501)
1112 .....||++.++|+|+||||+ | |+|.+|+++||.|.|.++. ++| ++++.+++... +..+..|||+|++|
1113 T Consensus 37 ~~~~~Cc~~~l~V~F~dlGW~-i-iaP~~~~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~~ 108 (135)
1114 T 1AGQ_C 37 GKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCEAAE------TMYDKILKNLSRSRRLTSDKVGQACCRPVAF 108 (135)
1115 T ss_dssp ----CCEEEEEEEEGGGGCSC-C-CCCCEEEEEEEESCCCCCC------SHHHHHHHHHHHTTCC----CCCCCEEEEEE
1116 T ss_pred CCCCCceEEEEEEEHHHcCCC-c-cCCCeEEeEEecCCCCCCc------chHHHHHHHHHhhcCCCCcccCCCeeeeeee
1117 Confidence 457899999999999999998 5 8999999999999999972 367 66666655432 33578999999999
1118
1119
1120 Q NP_000548.2 472 S-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1121 Q Consensus 472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1122 + +++ |++++ +++++++||+|++|||.
1123 T Consensus 109 ~~~l~--y~d~~--~~~~~l~dmiv~~CgC~ 135 (135)
1124 T 1AGQ_C 109 DDDLS--FLDDS--LVYHILRKHSAKRCGCI 135 (135)
1125 T ss_dssp CCCEE--EECSS--SCEEEECSCSEEEEEEC
1126 T ss_pred cCCee--eecCC--eEEEEEcCeEEecccCC
1127 Confidence 9 999 77765 47899999999999995
1128
1129
1130 No 40
1131 >5TX2_A Transforming growth factor beta-2; Growth factor, CYTOKINE; 1.82A {Mus musculus}
1132 Probab=99.66 E-value=2.9e-21 Score=157.69 Aligned_cols=81 Identities=33% Similarity=0.827 Sum_probs=74.0 Template_Neff=7.400
1133
1134 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501)
1135 Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501)
1136 ....||+++++|+|+ ||||+ |||+|++|+++||.|.|..+. .+.+||+|++|+++
1137 T Consensus 12 ~~~~C~~~~~~v~f~~dlgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~l 67 (93)
1138 T 5TX2_A 12 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL 67 (93)
1139 T ss_dssp CCSBSEEECCEEEHHHHHCCC-SEEECSEEECCEEECBCCCCS-----------------------SSCCCEEECCEEEE
1140 T ss_pred CCCCcEEEEEEEECchhcCCC-cEeCCCeEEcEEecccCCCCC-----------------------CCCCCceeceecce
1141 Confidence 478999999999999 99998 999999999999999998751 25799999999999
1142
1143
1144 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1145 Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1146 +|||++++ +++++.++||+|++|||+
1147 T Consensus 68 ~il~~~~~-~~~~~~l~~~~v~~CgC~ 93 (93)
1148 T 5TX2_A 68 TILYYIGN-TPKIEQLSNMIVKSCKCS 93 (93)
1149 T ss_dssp EEEEEETT-EEEEEEEEEEEECEEEEC
1150 T ss_pred EEEEEeCC-eEEEEEEcCcEEecCccC
1151 Confidence 99999986 578999999999999995
1152
1153
1154 No 41
1155 >5TX4_B TGF-beta receptor type-2 (E.C.2.7.11.30), Transforming; TGF-beta, TGF-beta type II receptor; 1.876A {Homo sapiens}
1156 Probab=99.66 E-value=3e-21 Score=157.29 Aligned_cols=81 Identities=31% Similarity=0.818 Sum_probs=74.3 Template_Neff=7.500
1157
1158 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501)
1159 Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501)
1160 ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+. .+.|||+|++|+++
1161 T Consensus 11 ~~~~C~~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~~ 66 (92)
1162 T 5TX4_B 11 VQDNCCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL 66 (92)
1163 T ss_pred CCCCcEEEEEEEECchhcCCC-ceeCCCeEEcEEeeccCCCCC-----------------------CCCCceeccccCce
1164 Confidence 467999999999998 99998 999999999999999998752 25799999999999
1165
1166
1167 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1168 Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1169 +|||++++ +++++.++||+|++|+|+
1170 T Consensus 67 ~il~~~~~-~i~~~~~~~~~v~~C~C~ 92 (92)
1171 T 5TX4_B 67 TIVYYVGR-KPKVEQLSNMIVKSCKCS 92 (92)
1172 T ss_pred eEEEEeCC-eeEEEEEcCeEEecCCCC
1173 Confidence 99999987 678999999999999995
1174
1175
1176 No 42
1177 >2GYZ_A neurotrophic factor artemin isoform 3; neurotrophic factor, cystine-knot, HORMONE-GROWTH FACTOR; 1.76A {Homo sapiens}
1178 Probab=99.57 E-value=1.4e-19 Score=150.88 Aligned_cols=89 Identities=18% Similarity=0.342 Sum_probs=71.6 Template_Neff=7.300
1179
1180 Q NP_000548.2 399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPTRL 471 (501)
1181 Q Consensus 399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~~~ 471 (501)
1182 .||+++++|+|+||||+ ||+|++|+++||.|+|..+.. ++ +.++.++.... +.....|||+|++|
1183 T Consensus 1 ~Cc~~~l~V~F~dlGw~--IiaP~~~~a~yC~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~~~pCC~P~~~ 72 (105)
1184 T 2GYZ_A 1 GCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRARS------PHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY 72 (105)
1185 T ss_dssp CCEEEEEEEEGGGGSSS--CCCSSEEEEEEEESCCGGGCC------HHHHHHHHHHHTTCSCCCSSSCCCSSCCCEEEEE
1186 T ss_pred CCeeEEEEEeHHHcCCc--cccCCceeceEEeccCCCCCC------chHHHHHHHHHhcCCCCCCCCCCCCCCeeeeeee
1187 Confidence 49999999999999998 899999999999999999853 22 23323332221 24578999999999
1188
1189
1190 Q NP_000548.2 472 SPISILFIDSA-NNVVYKQYEDMVVES 497 (501)
1191 Q Consensus 472 ~~l~ily~d~~-~~~~~~~~~~mvv~~ 497 (501)
1192 ++++ |+|++ +.+++++++||+|..
1193 T Consensus 73 ~~l~--y~d~~~~~i~~~~lp~m~~~~ 97 (105)
1194 T 2GYZ_A 73 EAVS--FMDVNSTWRTVDRLSATACGC 97 (105)
1195 T ss_dssp EEEE--EECTTSCEEEEEEEEEEEEEC
1196 T ss_pred ceee--EEeCCCCeEEEEEeccceeec
1197 Confidence 9999 88876 578899999999875
1198
1199
1200 No 43
1201 >6Q2S_B Ubiquitin-like protein SMT3,Artemin, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 3.8A {Saccharomyces cerevisiae}
1202 Probab=99.47 E-value=2.9e-18 Score=163.18 Aligned_cols=93 Identities=20% Similarity=0.483 Sum_probs=77.2 Template_Neff=8.400
1203
1204 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPT 469 (501)
1205 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~ 469 (501)
1206 ...||++.++|+|++|||+ ||+|.+|+++||.|.|..+. ++| +.++.+++... ......|||+|+
1207 T Consensus 135 ~~~C~~~~~~V~f~~lgw~--ii~P~~~~~~~C~G~C~~~~------~~~~~~~~~l~~~~~~~~~~~~~~~~~~CC~P~ 206 (235)
1208 T 6Q2S_B 135 ARGCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRPT 206 (235)
1209 T ss_pred CceeeeecCccchHHcCCe--eecCCeEECccccCCCCCCC------CCHHHHHHHHHHcCCCCCCCCCCCCCCCccCce
1210 Confidence 5789999999999999998 58999999999999999983 255 45555554332 135789999999
1211
1212
1213 Q NP_000548.2 470 RLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1214 Q Consensus 470 ~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1215 +|++++ |++++ +++++++||+|++|||+
1216 T Consensus 207 ~~~~l~--y~~~~--~~~~~~~~m~v~~CgC~ 234 (235)
1217 T 6Q2S_B 207 RYEAVS--FMDVN--STWRTVDRLSATACGCL 234 (235)
1218 T ss_pred ecCeee--eecCC--eEEEEeCCcEEeccccc
1219 Confidence 999988 77764 67899999999999995
1220
1221
1222 No 44
1223 >6GFF_E Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: BMA, MAN, NAG; 3.1A {Mus musculus}
1224 Probab=98.95 E-value=1.1e-13 Score=131.10 Aligned_cols=158 Identities=22% Similarity=0.234 Sum_probs=101.3 Template_Neff=9.700
1225
1226 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501)
1227 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501)
1228 .+||++|||+++|+++.. .+.+++++|++||+.+......... ..+.+....+++|++|......... .
1229 T Consensus 22 ~~IL~~Lgl~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 97 (249)
1230 T 6GFF_E 22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 97 (249)
1231 T ss_pred HHHHHHcCCCCCCCCCCC----CCCCccHHHHHHHHhhhccccCCCCCcccCCcccchhcccceeeeecCCCCCCCcccC
1232 Confidence 689999999999998651 1245689999999987665321100 0111223456788888654332100 1
1233
1234
1235 Q NP_000548.2 216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501)
1236 Q Consensus 216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501)
1237 ......+.|++++++ . +.|.+|+||||+..... ...|.||...... ...++..+.+.....++
1238 T Consensus 98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~ 165 (249)
1239 T 6GFF_E 98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE 165 (249)
1240 T ss_pred CCCcEEEEEecccCCCCCCCccceEEEEEEEEeCCCCC-----------cEEEEEEEecCCC-ceeEEEEEEeecCCCCc
1241 Confidence 234677999999742 2 47999999999987642 3566777643210 11123333221234579
1242
1243
1244 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAW 316 (501)
1245 Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~ 316 (501)
1246 |+.||||.+|+.|+.++ +++|.|.+.
1247 T Consensus 166 W~~~dvt~~v~~W~~~~~~n~gl~v~v~ 193 (249)
1248 T 6GFF_E 166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH 193 (249)
1249 T ss_pred eEEEEcHHHHHHHHhCCcccceEEEEEE
1250 Confidence 99999999999999986 788886554
1251
1252
1253 No 45
1254 >6GFF_G Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: MAN, NAG, BMA; 3.1A {Mus musculus}
1255 Probab=98.95 E-value=1.1e-13 Score=131.18 Aligned_cols=158 Identities=22% Similarity=0.234 Sum_probs=101.5 Template_Neff=9.600
1256
1257 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501)
1258 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501)
1259 .+||++|||+++|++... .+.+++++|++||+.+......... ..+.+....+++|++|......... .
1260 T Consensus 22 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 97 (249)
1261 T 6GFF_G 22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 97 (249)
1262 T ss_dssp HHHHHHTTCSSCCCSTTC----CSSSCCHHHHHHHHHHHSCCCCC-------CGGGTSCEEEEEEECCCCCCCCHHHSCC
1263 T ss_pred HHHHHHcCCCCCCCCCCC----CCCCChHHHHHHHHHHHhhccCCCCCCCCCChhhhhhheeEeeEEeeccccccccccc
1264 Confidence 689999999999998651 2235689999999987655321100 0111223456788887654332100 1
1265
1266
1267 Q NP_000548.2 216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501)
1268 Q Consensus 216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501)
1269 ......+.|++++++ . +.|.+|+||||+..... ...|.||...... ...++..+.+.....++
1270 T Consensus 98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~ 165 (249)
1271 T 6GFF_G 98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE 165 (249)
1272 T ss_dssp CTTEEEEEEEHHHHHHHSSSGGGEEEEEEEEEECCBSS-----------CEEEEEEECCSSS-CCEEEEEEEECCBSSCE
1273 T ss_pred CCCcEEEEeehHHhhccCCCcceEEEEEEEEEEcCCCc-----------eEEEEEEEecCCC-ceeEeEEEEeCCCCCCC
1274 Confidence 234677999999752 2 47999999999987642 3567777643210 11123333221234579
1275
1276
1277 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAW 316 (501)
1278 Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~ 316 (501)
1279 |+.||||.+|+.|+.++ +++|.|.+.
1280 T Consensus 166 W~~~dVt~~v~~W~~~~~~n~~l~v~v~ 193 (249)
1281 T 6GFF_G 166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH 193 (249)
1282 T ss_dssp EEEEECHHHHHHHHHSCCSEEEEEEEEC
1283 T ss_pred eEEEEhHHHHHHHHHcCCCccCEEEEEE
1284 Confidence 99999999999999987 788886554
1285
1286
1287 No 46
1288 >5HLZ_E Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; 2.851A {Homo sapiens}
1289 Probab=98.74 E-value=1.8e-12 Score=124.55 Aligned_cols=155 Identities=15% Similarity=0.223 Sum_probs=99.6 Template_Neff=9.000
1290
1291 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG------N----SSVKLEAGLANTITSFIDKGQDD 212 (501)
1292 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~------~----~~~~~~~~~~n~Vrsf~~~~~~~ 212 (501)
1293 .+||++|||+.+|+++.. .+ .+++|++||+.+........ + ..++.....+++|++|.+.+.
1294 T Consensus 41 ~~IL~~LGl~~~P~~~~~----~~--~p~~M~~LY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~I~sf~~~~~-- 112 (270)
1295 T 5HLZ_E 41 KHILNMLHLKKRPDVTQP----VP--KAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGT-- 112 (270)
1296 T ss_pred HHHHHHcCCCCCCCCCCC----CC--hHHHHHHHHHhhcCcccCCCceeccccccchhhhhhhhcceEEEEEEecCCC--
1297 Confidence 689999999999998651 11 38999999998765442100 0 001123345678888876532
1298
1299
1300 Q NP_000548.2 213 RGPVVRKQRYVFDISA-LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR------------------ 272 (501)
1301 Q Consensus 213 ~~~~~~~~~l~FnlSs-i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~------------------ 272 (501)
1302 ....+.|+++. .+. +.|.+|+||||+....... ......+.||......
1303 T Consensus 113 -----~~~~l~F~~s~~~~~~~~v~~AeL~l~~~~~~~~~------~~~~~~i~vy~~~~~~~~~~~~~~~~~~~g~~~~ 181 (270)
1304 T 5HLZ_E 113 -----ARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGE 181 (270)
1305 T ss_pred -----ccEEEEEEecCCCCCceeEEEEEEEEEEeCCCcCC------CcceEEEEEEEEeeCCCCCCCCCchhhhhcCCcc
1306 Confidence 34578999987 433 4699999999998764310 1124566777543210
1307
1308
1309 Q NP_000548.2 273 QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWE 317 (501)
1310 Q Consensus 273 ~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~ 317 (501)
1311 ....++.++.+ .....+|++|||+.+|+.|+..+ +++|.|.+..
1312 T Consensus 182 ~~~~ll~s~~v-~~~~~gW~~fdVt~~v~~W~~~~~~n~gl~v~~~~ 227 (270)
1313 T 5HLZ_E 182 RSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQ 227 (270)
1314 T ss_pred ceEEEEEEEEe-ecCCCceEEEEChHHHHHHHHcCCCCeeEEEEEEe
1315 Confidence 01112333333 23457999999999999999986 7898887754
1316
1317
1318 No 47
1319 >4YCG_B pro-BMP9 prodomain, human BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: NAG, ZN; 3.3A {Mus musculus}
1320 Probab=98.69 E-value=3.5e-12 Score=124.35 Aligned_cols=152 Identities=18% Similarity=0.323 Sum_probs=81.5 Template_Neff=8.500
1321
1322 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR 218 (501)
1323 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~ 218 (501)
1324 .+||++|||.++|++... ...+++||++||+.+...... ...+++|++|.+....... ....
1325 T Consensus 41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~ 106 (296)
1326 T 4YCG_B 41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ 106 (296)
1327 T ss_dssp -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE
1328 T ss_pred HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC
1329 Confidence 589999999999997641 124589999999987655321 1245677777654332110 0124
1330
1331
1332 Q NP_000548.2 219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG 290 (501)
1333 Q Consensus 219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g 290 (501)
1334 ...+.|+++ ++. +.|..|+||||+........ .......|.||....... ...++... .....+
1335 T Consensus 107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g 178 (296)
1336 T 4YCG_B 107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG 178 (296)
1337 T ss_dssp EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTG----GGCCCEEEEEEEEEECCSSCSSSSSEEEEEEEE---EECSSE
1338 T ss_pred cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe
1339 Confidence 567899998 653 68999999999887643110 011245677776432100 01112222 234579
1340
1341
1342 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA----QLCLELEAW 316 (501)
1343 Q Consensus 291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~ 316 (501)
1344 |+.||||.+|+.|+.++ +++|+|.+.
1345 T Consensus 179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~ 208 (296)
1346 T 4YCG_B 179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ 208 (296)
1347 T ss_dssp EEEEECHHHHHHHHSCCSSSCCSEEEEEEE
1348 T ss_pred eEEEEhHHHHHHHHHCCCCCCCceEEEEEE
1349 Confidence 99999999999999985 478887664
1350
1351
1352 No 48
1353 >4YCI_B mouse pro-BMP9 prodomain, pro-BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: ZN, NAG; 3.25A {Mus musculus}
1354 Probab=98.69 E-value=3.5e-12 Score=124.35 Aligned_cols=152 Identities=18% Similarity=0.323 Sum_probs=81.5 Template_Neff=8.500
1355
1356 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR 218 (501)
1357 Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~ 218 (501)
1358 .+||++|||.++|++... ...+++||++||+.+...... ...+++|++|.+....... ....
1359 T Consensus 41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~ 106 (296)
1360 T 4YCI_B 41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ 106 (296)
1361 T ss_dssp -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE
1362 T ss_pred HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC
1363 Confidence 589999999999997641 124589999999987655321 1245677777654332110 0124
1364
1365
1366 Q NP_000548.2 219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG 290 (501)
1367 Q Consensus 219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g 290 (501)
1368 ...+.|+++ ++. +.|..|+||||+........ .......|.||....... ...++... .....+
1369 T Consensus 107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g 178 (296)
1370 T 4YCI_B 107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG 178 (296)
1371 T ss_dssp EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTC----TTCCCEEEEEEEEEECCSSCSTTSSEEEEEEEE---EECSSE
1372 T ss_pred cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe
1373 Confidence 567899998 653 68999999999887643110 011245677776432100 01112222 234579
1374
1375
1376 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA----QLCLELEAW 316 (501)
1377 Q Consensus 291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~ 316 (501)
1378 |+.||||.+|+.|+.++ +++|+|.+.
1379 T Consensus 179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~ 208 (296)
1380 T 4YCI_B 179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ 208 (296)
1381 T ss_dssp EEEEECHHHHHHHHSCTTSSCCSEEEEEEE
1382 T ss_pred eEEEEhHHHHHHHHHCCCCCCCceEEEEEE
1383 Confidence 99999999999999985 478887664
1384
1385
1386 No 49
1387 >4NT5_A von Willebrand factor; cystine knot, dimerization of VWF; HET: SO4, NAG; 3.281A {Homo sapiens}
1388 Probab=75.72 E-value=0.27 Score=37.97 Aligned_cols=65 Identities=22% Similarity=0.456 Sum_probs=39.6 Template_Neff=7.800
1389
1390 Q NP_000548.2 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1391 Q Consensus 422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1392 ..+..++|.|.|...... +... . .....-.||.|.++....|...=.+|.. ..+.=+++.+|+|.
1393 T Consensus 37 ~~v~~~~C~G~C~S~~~~-----~~~~--~------~~~~~c~CC~p~~~~~~~v~L~C~~g~~--~~~~~~~i~~C~C~ 101 (107)
1394 T 4NT5_A 37 VEVDIHYCQGKCASKAMY-----SIDI--N------DVQDQCSCCSPTRTEPMQVALHCTNGSV--VYHEVLNAMECKCS 101 (107)
1395 T ss_dssp SCEEEEECCCBCCEEEEE-----ETTT--T------EEEEEEEEEEESSEEEEEEEEECTTSCE--EEEEEEEECCEEEE
1396 T ss_pred eeeeceEEeEeecCceee-----cCCc--c------ceEeecCcccCeEeEeEEEEEECCCCCE--EEEEEEeeeeceEE
1397 Confidence 567889999999875321 1100 0 0123578999999987776444333332 23344678899994
1398
1399
1400 No 50
1401 >2KD3_A Sclerostin; Protein, antagonist of CYTOKINE, PROTEIN; NMR {Mus musculus}
1402 Probab=73.48 E-value=0.35 Score=38.01 Aligned_cols=73 Identities=15% Similarity=0.291 Sum_probs=40.9 Template_Neff=6.600
1403
1404 Q NP_000548.2 419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANN-VVYKQYEDMVVES 497 (501)
1405 Q Consensus 419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~-~~~~~~~~mvv~~ 497 (501)
1406 ++.+.+...+|.|.|....... ...... ... . ......||.|.++....|.+.=.+|. .+ ...-+.|.+
1407 T Consensus 39 ~S~~~v~~~~C~G~C~s~s~~~---~~~~~~-~~~-~---~~~~c~CC~p~~t~~r~V~l~C~dG~~~~--~~~~~~V~~ 108 (113)
1408 T 2KD3_A 39 RSAKPVTELVCSGQCGPARLLP---NAIGRV-KWW-R---PNGPDFRCIPDRYRAQRVQLLCPGGAAPR--SRKVRLVAS 108 (113)
1409 T ss_dssp EECCCCCBCCCCCCCSCCCCCC---CCTTCC-SSS-C---SSCCCCCCEEEEEEEEEEEEECTTSEE------EEEEEEE
1410 T ss_pred eeCCccccceeeeeCCCCccCC---cccCCC-Ccc-c---ccCCCccccCceeEEEEEEEECCCCCeeE--EEEeEEEee
1411 Confidence 4456678889999998653210 000000 000 0 12357899999999877655433342 22 334468899
1412
1413
1414 Q NP_000548.2 498 CGCR 501 (501)
1415 Q Consensus 498 CgC~ 501 (501)
1416 |+|.
1417 T Consensus 109 C~C~ 112 (113)
1418 T 2KD3_A 109 CKCK 112 (113)
1419 T ss_dssp EECC
1420 T ss_pred cccC
1421 Confidence 9994
1422
1423
1424 No 51
1425 >4YU8_A Neuroblastoma suppressor of tumorigenicity 1; BMP Binding Protein, NBL1 DAN; HET: NAG; 1.8A {Homo sapiens}
1426 Probab=70.00 E-value=0.48 Score=38.53 Aligned_cols=88 Identities=13% Similarity=0.121 Sum_probs=41.4 Template_Neff=7.100
1427
1428 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501)
1429 Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501)
1430 ..|....+...+..=| - . +..+..++|.|.|....... ... ... .....-.||.|.++....|-
1431 T Consensus 32 ~~C~~~~~~~~I~~~g---C-~-s~~V~~~~C~G~C~S~s~~~----~~~---~~~----~~~~~CsCC~p~~~~~~~V~ 95 (139)
1432 T 4YU8_A 32 AWCEAKNITQIVGHSG---C-E-AKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT 95 (139)
1433 T ss_dssp CEEEEEEEEEEECCTT---S-C-CEEEEEEEEEEECCC------------------------------EEEEEEEEEEEE
1434 T ss_pred CccEEEeeEEEEecCC---c-e-eeeeecceeeceecccccCC----CCC---CCc----cceeecCcccCeEEEEEEEE
1435 Confidence 3566555444443211 1 2 25678899999998753210 000 000 01123469999999977664
1436
1437
1438 Q NP_000548.2 478 FIDSANNV-VYKQYEDMVVESCGCR 501 (501)
1439 Q Consensus 478 y~d~~~~~-~~~~~~~mvv~~CgC~ 501 (501)
1440 ..=.++.. ....+.=..+.+|+|.
1441 T Consensus 96 L~C~~g~~~~~~~~~~~~v~sC~C~ 120 (139)
1442 T 4YU8_A 96 LECPGHEEVPRVDKLVEKILHCSCQ 120 (139)
1443 T ss_dssp EECTTCSSSCEEEEEEEEEEEEEEC
1444 T ss_pred EeCCCCCCcccEEEEEEeeeecccc
1445 Confidence 33233322 0022333478999995
1446
1447
1448 No 52
1449 >2K8P_A Sclerostin; WNT SIGNALLING PATHWAY, BONE FORMATION; NMR {Homo sapiens}
1450 Probab=66.67 E-value=0.66 Score=39.89 Aligned_cols=74 Identities=18% Similarity=0.288 Sum_probs=43.0 Template_Neff=5.300
1451
1452 Q NP_000548.2 419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESC 498 (501)
1453 Q Consensus 419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~C 498 (501)
1454 .+.+.+...+|.|.|...... .+.. -...... ......||+|.+.....|-+.=.+|. ....+.-|+|.+|
1455 T Consensus 71 ~S~kpV~~~~C~G~C~~~s~~----~~~~-~~~k~~~---~~~~~~CC~P~rTrtrrV~f~C~DGt-~t~~~~v~~V~sC 141 (189)
1456 T 2K8P_A 71 RSAKPVTELVCSGQCGPARLL----PNAI-GRGKWWR---PSGPDFRCIPDRYRAQRVQLLCPGGE-APRARKVRLVASC 141 (189)
1457 T ss_dssp EESSCEEEEEECCCCCCCCCC----SSCC-CSSCCCS---CCCCCCCCEECCEEEEEEEEECCTTS-CCEEEEEEEECCE
1458 T ss_pred ecCCceeeeEEeeeCCCcccC----CCcc-cCCCccC---CCCCCCCCCCCeeEEEEEEEECCCCC-cceeEEeeEeeeC
1459 Confidence 556777889999999864321 0100 0000001 12357899999988766655434342 0123345789999
1460
1461
1462 Q NP_000548.2 499 GCR 501 (501)
1463 Q Consensus 499 gC~ 501 (501)
1464 +|.
1465 T Consensus 142 kCk 144 (189)
1466 T 2K8P_A 142 KCK 144 (189)
1467 T ss_dssp ECC
1468 T ss_pred CCc
1469 Confidence 994
1470
1471
1472 No 53
1473 >4JPH_D Gremlin-2; Cystine knot, DAN domain, CAN; HET: GSH, GOL, CIT; 2.25A {Mus musculus}
1474 Probab=65.08 E-value=0.72 Score=37.91 Aligned_cols=88 Identities=14% Similarity=0.239 Sum_probs=48.1 Template_Neff=6.700
1475
1476 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501)
1477 Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501)
1478 ..|....+...+..=|= .+ ..+..++|.|.|....... ....... ....-.||.|.++....|.
1479 T Consensus 51 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~p~----~~~~~~~-------~~~~CsCC~p~~~~~~~V~ 114 (148)
1480 T 4JPH_D 51 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE 114 (148)
1481 T ss_dssp CEEEEEEEEEEECCTTS----CC-EEEEEEEEEEEEEEEEEEC----CCSSSCC-------EEEEEEEEEEEEEEEEEEE
1482 T ss_pred CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE
1483 Confidence 45776666555442221 22 4678899999998643210 0000000 1234689999999976664
1484
1485
1486 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501)
1487 Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1488 ..=.++.-......=..|.+|+|.
1489 T Consensus 115 L~C~~g~~~~~~~~v~~V~sC~C~ 138 (148)
1490 T 4JPH_D 115 LECPGLDPPFRIKKIQKVKHCRCM 138 (148)
1491 T ss_dssp ECCTTSSSSCEEEEEEEEEEEEEE
1492 T ss_pred EeCCCCCCCceEEEEEeeeeCcee
1493 Confidence 332222211122334588999995
1494
1495
1496 No 54
1497 >4X1J_B Neuroblastoma suppressor of tumorigenicity 1; BMP antagonist, DAN family, Cystine-knot; HET: NAG; 2.5A {Homo sapiens}
1498 Probab=64.18 E-value=0.74 Score=35.85 Aligned_cols=88 Identities=13% Similarity=0.131 Sum_probs=46.1 Template_Neff=7.700
1499
1500 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501)
1501 Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501)
1502 ..|....+...+..=|= .+..+..++|.|.|....... ... ... .....-.||.|.++....|.
1503 T Consensus 17 ~~C~~~~~~~~i~~~gC-----~s~~i~~~~C~G~C~S~~~~~----~~~---~~~----~~~~~C~CC~p~~~~~~~V~ 80 (116)
1504 T 4X1J_B 17 AWCEAKNITQIVGHSGC-----EAKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT 80 (116)
1505 T ss_dssp CEEEEEEEEEEECCTTS-----CCEEEEEEEEEEEEEEEECC------------------CTTEEEEEEEEEEEEEEEEE
1506 T ss_pred CccEEEEeEEEEccCCc-----cceeEecceEeeeeeeeeecC----CCC---CCC----cceeecCCccceEEEEEEEE
1507 Confidence 35666555444432111 123578899999998643210 000 000 01234579999999987764
1508
1509
1510 Q NP_000548.2 478 FIDSANNV-VYKQYEDMVVESCGCR 501 (501)
1511 Q Consensus 478 y~d~~~~~-~~~~~~~mvv~~CgC~ 501 (501)
1512 ..=.++.- ......=.++.+|+|.
1513 T Consensus 81 L~C~~g~~~~~~~~~~~~v~~C~C~ 105 (116)
1514 T 4X1J_B 81 LECPGHEEVPRVDKLVEKILHCSCQ 105 (116)
1515 T ss_dssp EECTTCSSSSEEEEEEEEEEEEEEE
1516 T ss_pred EECCCCCCCccEEEEEEeeEecccc
1517 Confidence 43233322 1122333478999995
1518
1519
1520 No 55
1521 >5AEJ_A GREMLIN-1; SIGNALING PROTEIN, SIGNALING, GREMLIN, GROWTH; HET: SO4; 1.904A {HOMO SAPIENS}
1522 Probab=62.64 E-value=0.87 Score=37.64 Aligned_cols=87 Identities=15% Similarity=0.248 Sum_probs=48.6 Template_Neff=6.100
1523
1524 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI 476 (501)
1525 Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i 476 (501)
1526 ...|....+...+..=|= . +..+..++|.|.|...... ... . .. . .....-.||.|.++....|
1527 T Consensus 59 ~~~C~~~~~~q~I~~~gC----~-S~~V~~~~C~G~C~S~s~p-----s~~-~-~~---~-~~~~~CsCC~p~~s~~~~V 122 (152)
1528 T 5AEJ_A 59 RDWCKTQPLKQTIHEEGC----N-SRTIINRFCYGQCNSFYIP-----RHI-R-KE---E-GSFQSCSFCKPKKFTTMMV 122 (152)
1529 T ss_dssp CCEEEEEEEEEEECCTTS----C-CEEEEEEEEEEEEEEEEEE-----EEE-T-TE---E-EEEEEEEEEEEEEEEEEEE
1530 T ss_pred CCceeeeeceeEEccCCc----e-eceEEeeeceeecccCeec-----ccc-c-cc---C-CceeecCcccceEEEEEEE
1531 Confidence 456877766555542221 2 2568899999999864321 100 0 00 0 0122467999999987666
1532
1533
1534 Q NP_000548.2 477 LFIDSANNV--VYKQYEDMVVESCGCR 501 (501)
1535 Q Consensus 477 ly~d~~~~~--~~~~~~~mvv~~CgC~ 501 (501)
1536 ...=.++.. +.+.+ ..+.+|.|.
1537 T Consensus 123 ~L~Cpdg~~~~~~~~v--~~V~sC~C~ 147 (152)
1538 T 5AEJ_A 123 TLNCPELQPPTKKKRV--TRVKQCRCI 147 (152)
1539 T ss_dssp EEECTTSSSSEEEEEE--EEEEEEEEE
1540 T ss_pred EEECCCCCCCceEEEE--EeceeceeE
1541 Confidence 333222322 23333 578999995
1542
1543
1544 No 56
1545 >5HK5_G Gremlin-2, Growth/differentiation factor 5; DAN-family, Bone Morphogenetic Proteins, CYTOKINE; 2.9A {Mus musculus}
1546 Probab=61.90 E-value=0.91 Score=37.23 Aligned_cols=86 Identities=15% Similarity=0.240 Sum_probs=46.5 Template_Neff=6.600
1547
1548 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501)
1549 Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501)
1550 ..|....+...+..=|= .+ ..+..++|.|.|....... ....... ....-.||.|.++....|.
1551 T Consensus 50 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~ps----~~~~~~~-------~~~~CsCC~p~~~~~~~V~ 113 (147)
1552 T 5HK5_G 50 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE 113 (147)
1553 T ss_pred CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE
1554 Confidence 35665555544432121 22 4578899999998643210 0000000 1234679999999976663
1555
1556
1557 Q NP_000548.2 478 FIDSANNV--VYKQYEDMVVESCGCR 501 (501)
1558 Q Consensus 478 y~d~~~~~--~~~~~~~mvv~~CgC~ 501 (501)
1559 ..=.++.. +.+. =.+|.+|+|.
1560 T Consensus 114 L~C~dg~~~~~~~~--~~~V~sC~C~ 137 (147)
1561 T 5HK5_G 114 LECPGLDPPFRIKK--IQKVKHCRCM 137 (147)
1562 T ss_pred EeCCCCCCCceEEE--EEeeeeCcee
1563 Confidence 33222221 2333 3578999994
1564
1565
1566 No 57
1567 >5BPU_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: GGL; 2.4A {Homo sapiens}
1568 Probab=57.82 E-value=1.2 Score=34.98 Aligned_cols=72 Identities=21% Similarity=0.280 Sum_probs=38.3 Template_Neff=7.700
1569
1570 Q NP_000548.2 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501)
1571 Q Consensus 422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1572 ..+..++|.|.|....... ........ ........-.||.|.++....+...=.++..+. ..-.++.+|.|.
1573 T Consensus 37 ~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~v~l~C~~g~~~~--~~~~~i~~C~C~ 108 (122)
1574 T 5BPU_A 37 KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLT--ATYRYILSCHCE 108 (122)
1575 T ss_pred CcEeceeeeccccceeecC----CCcccCCC--CCCcceeeeecCcCeEeEEEEEEEECCCCCeEE--EEEEEEEeceee
1576 Confidence 6678899999998753200 00000000 000012345899999988766533323332222 333478899994
1577
1578
1579 No 58
1580 >5BQ8_C Norrin; Wnt signalling pathway, Norrie disease; HET: MLY; 2.0A {Homo sapiens}
1581 Probab=53.96 E-value=1.5 Score=34.27 Aligned_cols=93 Identities=19% Similarity=0.268 Sum_probs=46.5 Template_Neff=7.800
1582
1583 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501)
1584 Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501)
1585 ..|....+...+..=.. .- .. ..+..++|.|.|....... ........ ........-.||.|.++....|.
1586 T Consensus 16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~ 86 (122)
1587 T 5BQ8_C 16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR 86 (122)
1588 T ss_dssp TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCEETTB--CCCSEEEECEEEEEEEEEEEEEE
1589 T ss_pred CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE
1590 Confidence 45666555444432100 11 22 6678899999998753200 00000000 00001234589999998876653
1591
1592
1593 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501)
1594 Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1595 ..=.++..+ ...-+++.+|.|.
1596 T Consensus 87 l~C~~g~~~--~~~~~~i~~C~C~ 108 (122)
1597 T 5BQ8_C 87 LRCSGGMRL--TATYRYILSCHCE 108 (122)
1598 T ss_dssp EEETTTEEE--EEEEEEEEEEEEE
1599 T ss_pred EECCCCceE--EEEEEEEEeceee
1600 Confidence 332333322 2334578999994
1601
1602
1603 No 59
1604 >5BQE_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: MLY, NAG, PG0; 2.3A {Homo sapiens}
1605 Probab=53.96 E-value=1.5 Score=34.27 Aligned_cols=93 Identities=19% Similarity=0.268 Sum_probs=46.5 Template_Neff=7.800
1606
1607 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501)
1608 Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501)
1609 ..|....+...+..=.. .- .. ..+..++|.|.|....... ........ ........-.||.|.++....|.
1610 T Consensus 16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~ 86 (122)
1611 T 5BQE_A 16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR 86 (122)
1612 T ss_dssp TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCBCSSS--CSSCEEEECEEEEEEEEEEEEEE
1613 T ss_pred CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE
1614 Confidence 45666555444432100 11 22 6678899999998753200 00000000 00001234589999998876653
1615
1616
1617 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501)
1618 Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501)
1619 ..=.++..+ ...-+++.+|.|.
1620 T Consensus 87 l~C~~g~~~--~~~~~~i~~C~C~ 108 (122)
1621 T 5BQE_A 87 LRCSGGMRL--TATYRYILSCHCE 108 (122)
1622 T ss_dssp EEBSSSCEE--EEEEEEEEEEEEE
1623 T ss_pred EECCCCceE--EEEEEEEEeceee
1624 Confidence 332333322 2334578999994
1625
1626