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view test-data/create/NP_000548.2.hhr @ 0:ad4b7db26523 draft
"planemo upload commit b68cb41b1884703c4f1574b65a6408d7d0cca321"
| author | guerler |
|---|---|
| date | Tue, 23 Mar 2021 23:06:45 +0000 |
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Query NP_000548.2 Match_columns 501 No_of_seqs 1691 out of 7065 Neff 7.55495 Searched_HMMs 400 Date Sat Jul 25 00:10:29 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000548.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000548.2.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 5FFO_H Integrin alpha-V, Integ 100.0 2.3E-42 2.1E-46 353.3 0.0 315 143-501 24-363 (363) 2 3RJR_C Transforming growth fac 100.0 3.4E-42 3.1E-46 351.8 0.0 315 143-501 24-363 (363) 3 5VQF_C Transforming growth fac 100.0 3.4E-42 3.2E-46 351.8 0.0 315 143-501 24-363 (363) 4 5NTU_A Growth/differentiation 100.0 9.5E-42 8.8E-46 343.8 0.0 309 142-501 17-335 (335) 5 5HLY_A Inhibin beta A chain; G 100.0 3E-39 2.7E-43 332.7 0.0 307 142-501 40-383 (383) 6 6SF3_B Serine/threonine-protei 99.8 1.5E-26 1.3E-30 194.7 0.0 105 397-501 4-108 (108) 7 4MPL_A Growth/differentiation 99.8 2.3E-26 2E-30 196.3 0.0 106 396-501 10-116 (116) 8 6Z3J_B Growth/differentiation 99.8 2.6E-26 2.3E-30 196.2 0.0 107 395-501 11-117 (117) 9 5I05_A Growth/differentiation 99.8 4E-26 3.5E-30 192.9 0.0 106 396-501 4-110 (110) 10 4N1D_A Bone morphogenetic prot 99.8 4.5E-26 3.9E-30 194.5 0.0 106 396-501 11-116 (116) 11 2QCQ_B Bone morphogenetic prot 99.8 5.7E-26 5E-30 191.9 0.0 105 397-501 5-110 (110) 12 1LXI_A BONE MORPHOGENETIC PROT 99.8 9E-26 7.8E-30 198.7 0.0 111 391-501 29-139 (139) 13 6OMN_G Bone morphogenetic prot 99.8 9.8E-26 8.7E-30 189.8 0.0 105 396-501 4-108 (108) 14 2R53_A Bone morphogenetic prot 99.8 9.9E-26 8.7E-30 192.3 0.0 106 396-501 11-116 (116) 15 2R53_B Bone morphogenetic prot 99.8 9.9E-26 8.7E-30 192.3 0.0 106 396-501 11-116 (116) 16 1REU_A bone morphogenetic prot 99.8 1.1E-25 1E-29 187.7 0.0 102 399-501 2-103 (103) 17 1M4U_L Bone Morphogenetic Prot 99.8 1.2E-25 1.1E-29 197.8 0.0 111 391-501 29-139 (139) 18 2H62_B Bone morphogenetic prot 99.8 2.1E-25 1.9E-29 189.6 0.0 105 396-501 10-114 (114) 19 6Q2J_B Growth/differentiation 99.8 3.8E-25 3.2E-29 193.7 0.0 102 396-501 34-135 (135) 20 1KTZ_A TRANSFORMING GROWTH FAC 99.8 7.5E-25 6.6E-29 185.6 0.0 102 395-501 10-112 (112) 21 5TY4_B TGF-beta receptor type- 99.8 9.9E-25 8.8E-29 179.9 0.0 96 400-500 1-97 (97) 22 5VT2_B Growth/differentiation 99.8 1.1E-24 9.5E-29 184.6 0.0 102 396-501 11-112 (112) 23 5VZ3_A Growth/differentiation 99.8 1.1E-24 9.5E-29 184.6 0.0 102 396-501 11-112 (112) 24 2ARP_A Inhibin beta A chain, F 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116) 25 2ARV_A Inhibin beta A chain; h 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116) 26 2P6A_B Activin A, Follistatin 99.8 1.3E-24 1.2E-28 184.9 0.0 105 397-501 8-116 (116) 27 2TGI_A TRANSFORMING GROWTH FAC 99.8 1.5E-24 1.3E-28 183.7 0.0 101 396-501 11-112 (112) 28 3HH2_B Growth/differentiation 99.8 2.4E-24 2.1E-28 181.5 0.0 99 396-501 11-109 (109) 29 5F3B_C RK35 Chimeric antibody 99.8 2.4E-24 2.1E-28 181.5 0.0 99 396-501 11-109 (109) 30 3KFD_D Transforming growth fac 99.8 3.7E-24 3.2E-28 181.3 0.0 102 395-501 10-112 (112) 31 5E4G_A Growth/differentiation 99.8 1.2E-23 1.1E-27 177.0 0.0 99 396-501 11-109 (109) 32 5NMZ_B Neurturin; cystine knot 99.7 2.2E-22 1.9E-26 167.0 0.0 93 397-501 4-101 (101) 33 5NMZ_C Neurturin; cystine knot 99.7 2.2E-22 1.9E-26 167.0 0.0 93 397-501 4-101 (101) 34 2GH0_C artemin, GDNF family re 99.7 2.9E-22 2.6E-26 166.0 0.0 95 398-501 2-100 (101) 35 5MR4_B Neurturin, GDNF family 99.7 4.4E-22 3.9E-26 165.4 0.0 94 396-501 4-102 (102) 36 2V5E_B GDNF FAMILY RECEPTOR AL 99.7 7.4E-22 6.6E-26 163.6 0.0 93 397-501 5-101 (101) 37 2ASK_B artemin; Glial cell der 99.7 9.1E-22 8E-26 166.6 0.0 94 396-501 12-112 (113) 38 3FUB_D GDNF family receptor al 99.7 9.6E-22 8.1E-26 171.2 0.0 96 394-501 35-134 (134) 39 1AGQ_C GLIAL CELL-DERIVED NEUR 99.7 2.2E-21 1.8E-25 169.0 0.0 95 395-501 37-135 (135) 40 5TX2_A Transforming growth fac 99.7 2.9E-21 2.5E-25 157.7 0.0 81 396-501 12-93 (93) 41 5TX4_B TGF-beta receptor type- 99.7 3E-21 2.6E-25 157.3 0.0 81 396-501 11-92 (92) 42 2GYZ_A neurotrophic factor art 99.6 1.4E-19 1.2E-23 150.9 0.0 89 399-497 1-97 (105) 43 6Q2S_B Ubiquitin-like protein 99.5 2.9E-18 2.5E-22 163.2 0.0 93 397-501 135-234 (235) 44 6GFF_E Transforming growth fac 98.9 1.1E-13 1E-17 131.1 0.0 158 143-316 22-193 (249) 45 6GFF_G Transforming growth fac 98.9 1.1E-13 1E-17 131.2 0.0 158 143-316 22-193 (249) 46 5HLZ_E Inhibin beta A chain; G 98.7 1.8E-12 1.6E-16 124.5 0.0 155 143-317 41-227 (270) 47 4YCG_B pro-BMP9 prodomain, hum 98.7 3.5E-12 3.2E-16 124.4 0.0 152 143-316 41-208 (296) 48 4YCI_B mouse pro-BMP9 prodomai 98.7 3.5E-12 3.2E-16 124.4 0.0 152 143-316 41-208 (296) 49 4NT5_A von Willebrand factor; 75.7 0.27 2.4E-05 38.0 0.0 65 422-501 37-101 (107) 50 2KD3_A Sclerostin; Protein, an 73.5 0.35 3E-05 38.0 0.0 73 419-501 39-112 (113) 51 4YU8_A Neuroblastoma suppresso 70.0 0.48 4.1E-05 38.5 0.0 88 398-501 32-120 (139) 52 2K8P_A Sclerostin; WNT SIGNALL 66.7 0.66 5.3E-05 39.9 0.0 74 419-501 71-144 (189) 53 4JPH_D Gremlin-2; Cystine knot 65.1 0.72 6E-05 37.9 0.0 88 398-501 51-138 (148) 54 4X1J_B Neuroblastoma suppresso 64.2 0.74 6.5E-05 35.8 0.0 88 398-501 17-105 (116) 55 5AEJ_A GREMLIN-1; SIGNALING PR 62.6 0.87 7.2E-05 37.6 0.0 87 397-501 59-147 (152) 56 5HK5_G Gremlin-2, Growth/diffe 61.9 0.91 7.6E-05 37.2 0.0 86 398-501 50-137 (147) 57 5BPU_A Frizzled-4; Wnt signall 57.8 1.2 0.0001 35.0 0.0 72 422-501 37-108 (122) 58 5BQ8_C Norrin; Wnt signalling 54.0 1.5 0.00013 34.3 0.0 93 398-501 16-108 (122) 59 5BQE_A Frizzled-4; Wnt signall 54.0 1.5 0.00013 34.3 0.0 93 398-501 16-108 (122) No 1 >5FFO_H Integrin alpha-V, Integrin beta-6, Transforming; Integrin, TGF-beta, CELL ADHESION; HET: MAN, NAG, BMA; 3.49A {Homo sapiens} Probab=100.00 E-value=2.3e-42 Score=353.27 Aligned_cols=315 Identities=24% Similarity=0.379 Sum_probs=194.7 Template_Neff=9.300 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----N--SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~--~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|+.+.. .+.+++++|++||+.+........ . ..+.+.....++++++......... . T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 99 (363) T 5FFO_H 24 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 99 (363) T ss_dssp HHHHHHTTCSSCCCSSSS----CSSCCCHHHHHHHHHHSCCCCC--------CCSSSSCEEEEEEECBCTTSSSTTTTCC T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHHhhccCCCCCCCCCCcccceeeeEEEEEEeecCccccccccc Confidence 689999999999987642 223568999999998765431100 0 0011222234556666533221100 1 Q NP_000548.2 216 VVRKQRYVFDISA----LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSs----i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......++|++++ ++. +.|.+|+||||+..... ...|.||..... ....+++++.+.....++ T Consensus 100 ~~~~~~~~F~is~~~~~~~~~~~v~~AeLrl~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~~ 167 (363) T 5FFO_H 100 STHSIYMFFQTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-NSWRYLSNRLLAPSDSPE 167 (363) T ss_dssp BTTEEEEEECSTTHHHHSCSGGGEEEEEEECCBCCCCS-----------CCEEEEEEEETT-TEEEEEEEEECCCCSSCC T ss_pred ccceEEEEEechhccccCCCchhhcHhhhHhhcCccCc-----------cEEEEEEEecCc-ccceeeEeEEeCCCCCCC Confidence 2345678999997 433 57999999999887532 345677765421 111233333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWERG----RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~----~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501) |+.||||.+|+.|+.++ ++||.|.+.... ....+...++.. .......+|+|++++.+.... T Consensus 168 W~~fdVt~~v~~W~~~~~~n~gl~v~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------ 241 (363) T 5FFO_H 168 WLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363) T ss_dssp CCEEECHHHHHHHHHSCCSCEEEEEEECCBTTTTBCCCCCCBSCCTTTCCSSGGGGGGTTCCEEEEEECCTTTC------ T ss_pred eEEEEcHHHHHHHHHcCCccccEEEEEEecCCCCCCceeeeeccccCCcccchhhccccCCcEEEEEeCchHHH------ Confidence 99999999999999997 788886554311 111110101100 011124566666666432210 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501) Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501) . ..+.+++ ||+. + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++. T Consensus 242 ----~--------~~~~~r~-rr~~---~-~~~~~~~~~~~Cc~~~l~V~F~~~lgw~-~iiaP~~~~a~~C~G~C~~~~ 303 (363) T 5FFO_H 242 ----Q--------HLQSSRH-RRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363) T ss_dssp ----C-------------------------------CCSSSSEEECCCBCHHHHTCCC-SEEECCCBCCCEEECCCCCSC T ss_pred ----H--------hhhHHhh-Hhhc---c-cCCCCCCCcccceeeEEEEEccHHhCCc-eeeCCCeEEeeeccCCCCCcc Confidence 0 0000111 1110 1 1122233467899999999996 99998 999999999999999999997 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) .. +++|+.++++++...+..++.|||+|++|++|+|||+|++ .++++.++||+|++|||+ T Consensus 304 ~~---~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~ily~d~~-~~~~~~~~~m~v~~CgC~ 363 (363) T 5FFO_H 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363) T ss_dssp SC---C-----CCSSCTTTCSSCCSSCCEEECCEEEEEEEECC-C-CCEEEEEEEEEECCEEEC T ss_pred cc---cccHHHHHHHHHhhCCCCCCCCCcccceeceeeEEEEeCC-eeEEEEecCcEEeccCCC Confidence 63 5688988888776555568999999999999999999987 588999999999999995 No 2 >3RJR_C Transforming growth factor beta-1; TGF beta, activation, integrin, Cytokine; HET: NAG; 3.05A {Sus scrofa} Probab=100.00 E-value=3.4e-42 Score=351.82 Aligned_cols=315 Identities=24% Similarity=0.389 Sum_probs=198.8 Template_Neff=9.400 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|+.... .+.+++++|++||+.+........ .. .+.+......+++++......... . T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 99 (363) T 3RJR_C 24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG 99 (363) T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHhhcccccCCcCCCCCCCcccccchhccceEeecCCcccccccCC Confidence 689999999999987641 223568999999997654321100 00 001111122333333221110000 1 Q NP_000548.2 216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|+++++ +. +.|.+|+||||+..... ...+.||..... ....++.++.+.....++ T Consensus 100 ~~~~~~~~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g 167 (363) T 3RJR_C 100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE 167 (363) T ss_pred CccEEEEEEEcccCCCCCCcchhceEEEEEEEeCCCCC-----------CceEEEEEecCh-hheeEEEEEEeccCCCCc Confidence 13466899999974 22 47999999999887542 235667754321 111233333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501) |+.|||+.+|+.|+.++ ++||.|.+... . ..+.+...++.. .......+|+|++++.+.... T Consensus 168 W~~fdVt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------ 241 (363) T 3RJR_C 168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363) T ss_pred EEEEECHHHHHHHHhCCcccCcEEEEEEEccCCCCceeeEEEccccCCCcCCcccccccCCCEEEEEEcCCccc------ Confidence 99999999999999997 78888655321 1 111111001100 001124566666666432210 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501) Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501) ...+.++ +||+. + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++. T Consensus 242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgW~-wIiaP~~y~a~~C~G~C~~~~ 303 (363) T 3RJR_C 242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363) T ss_pred ------------ccccccc-ccccC---C-CCCCCCCCCCcccceeEEEecchhhCCc-eEecCCeEEeeeecccCCCCC Confidence 0000011 11110 1 1122223467899999999997 99997 999999999999999999997 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) .. .++|+.++++++...+..++.|||+|++|++|+|||+|++ ++++++++||+|++|||+ T Consensus 304 ~~---~t~ha~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~mvv~~CgC~ 363 (363) T 3RJR_C 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363) T ss_pred CC---cCcHHHHHHHHHhcCCCCCCCCcccccccCceEEEEEcCC-cEEEEEeCCeEEeeccCC Confidence 63 5689999988876555578999999999999999999987 588999999999999995 No 3 >5VQF_C Transforming growth factor beta-1; pro-complex, latency, homodimer, PROTEIN BINDING; HET: NAG, BMA; 2.9A {Sus scrofa} Probab=100.00 E-value=3.4e-42 Score=351.78 Aligned_cols=315 Identities=24% Similarity=0.389 Sum_probs=197.2 Template_Neff=9.400 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|++... .+.+++++|++||+.+........ .. .+.+.....++++++......... . T Consensus 24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 99 (363) T 5VQF_C 24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG 99 (363) T ss_dssp HHHHHHTTCSSCCCCTTC----CCSCCCHHHHHHHHHHHCCCBCC-------CCCCSSCEEEEEEECCCSSSSTTTSSTT T ss_pred HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHhhhcCCCCCCCCCCChhhheeeEEEEEEEeecCCceecccCC Confidence 689999999999987641 223568999999997655421100 00 001111122333333221110000 1 Q NP_000548.2 216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|+++++ +. +.|.+|+||||+..... ...+.||..... ....++.++.+.....++ T Consensus 100 ~~~~~~l~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g 167 (363) T 5VQF_C 100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE 167 (363) T ss_dssp CTTEEEEEEEHHHHHHHCSSGGGEEEEEEEEEECCCSS-----------CEEEEEEEECSS-SCEEEEEEEEECCCSSCE T ss_pred CCCeEEEEEEhhhccccCCCccceeeeEEEEEEcCCcc-----------ceEEEEEEecCc-ccceeEEeEEeCCCCCCC Confidence 13466899999974 22 47999999999887542 245667754321 111233333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI 358 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~ 358 (501) |+.|||+.+|+.|+.++ +++|.|.+... . ..+.+...++.. .......+|+|++++.+.... T Consensus 168 W~~fdvt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lvi~~~~~~~~------ 241 (363) T 5VQF_C 168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------ 241 (363) T ss_dssp EEEEECHHHHHHHHHCCCSEEEEEEEECEEEEEETTEEEEEEC------CCCSBCCSSTTCCEEEEEECCSTTT------ T ss_pred eEEEEcHHHHHHHHhhchhcCCEEEEEEeecCCCCCceeeEEccccCCCccchhhccccCCcEEEEEEChhHHh------ Confidence 99999999999999997 78888655321 1 111111001100 001124566666666432110 Q NP_000548.2 359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL 437 (501) Q Consensus 359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~ 437 (501) ...+.++ +||+. . ...+.......||+++++|+|+ ||||| |||+|++|+||||.|.|+++. T Consensus 242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgWd-wIiaP~~y~a~~C~G~C~~~~ 303 (363) T 5VQF_C 242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 303 (363) T ss_dssp ------------CC---------CE---E-HHHHTTSCCSSSEEECCEEETTTTTCCC-CEEECSEEECCEEECCCCCTT T ss_pred ------------hccchhh-hhhcc---C-cCccCCCCCccceeeEEEEEcchhhCCc-eeeCCCeEEeEeecCCCCCcC Confidence 0000011 11110 1 1122223467899999999997 99997 999999999999999999997 Q NP_000548.2 438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) .. .++|+.++++++...+..++.|||+|++|++|+|||+|++ +++++.++||+|++|||+ T Consensus 304 ~~---~t~ha~v~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~miv~~CgC~ 363 (363) T 5VQF_C 304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS 363 (363) T ss_dssp TS---CSCCHHHHTGGGGCCGGGSSSCCEEESSEEEEEEEEEETT-EEEEEEEEEEEECEEEEC T ss_pred Cc---cccHHHHHHHHHhcCCCCCCCCCccCcccceeeEEEEECC-eeEEEEecCcEEeccCCC Confidence 63 5689999988876555578999999999999999999987 588999999999999995 No 4 >5NTU_A Growth/differentiation factor 8; growth factor, signalling protein, TGFbeta; HET: EDO; 2.58A {Homo sapiens} Probab=100.00 E-value=9.5e-42 Score=343.78 Aligned_cols=309 Identities=22% Similarity=0.402 Sum_probs=196.1 Template_Neff=9.900 Q NP_000548.2 142 SSFLLKKAREPGPPREPKEPFR-P-PPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRK 219 (501) Q Consensus 142 ~~qIL~kLGL~~~P~~~~~~~~-~-~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~~~~~~ 219 (501) -.+||++|||+++|++....++ . +..+++++|+++|+.+....... ...++++...+++|++|.............. T Consensus 17 k~~IL~~LgL~~~P~~~~~~~~~~~~~~~~~~~l~~~y~~~~~~~~~~-~~~~~~~~~~~~~v~~f~~~~~~~~~~~~~~ 95 (335) T 5NTU_A 17 KIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDG-SLEDDDYHATTETIITMPTESDFLMQVDGKP 95 (335) T ss_pred HHHHHHHcCCCCCCCCCCCCCcccCCCCCchHHHHHHHhhccCCCCCC-CCcccchhcccceEEEeccCCCcccCCCCCC Confidence 4689999999999998763110 0 11225799999999765432110 0011223345567888865432210001245 Q NP_000548.2 220 QRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR---QPAALLDVRSVP-GLDGSGWEVF 294 (501) Q Consensus 220 ~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~---~~~~ll~s~~v~-~~~~~gWv~f 294 (501) ..++|+++++.. +.|.+|+||||+...... ....+.||...... .....+....+. ....++|++| T Consensus 96 ~~~~F~ls~~~~~~~v~~AeL~l~~~~~~~~---------~~~~v~vy~v~~~~~~~~~~~~~~~~~~~~~~~~~gW~~f 166 (335) T 5NTU_A 96 KCCFFKFSSKIQYNKVVKAQLWIYLRPVETP---------TTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSI 166 (335) T ss_pred eEEEEECCCCCCCcceeEEEEEEEECCCCCC---------CeEEEEEEEEEccCcCCceeeeeeEEEEEccCCCCcEEEE Confidence 678999997654 589999999999875431 13456666543210 000011111111 1234699999 Q NP_000548.2 295 DIWKLFRNFKNSA--QLCLELEAWERG-RAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYE 371 (501) Q Consensus 295 DVT~aV~~Wl~~~--nlgL~V~~~~~~-~~~~v~~~~~~~~~~~~~~~ppLLv~~~~~~~~~~~~~~~~~~~~~~~~~~~ 371 (501) |||.+|++|+.++ ++||.|.+...+ ....+ .+.... ....+|+|++++.+.. T Consensus 167 dVt~~v~~W~~~~~~n~gl~v~~~~~~~~~~~~---~~~~~~-~~~~~P~Lvi~~~~~~--------------------- 221 (335) T 5NTU_A 167 DVKTVLQNWLAAPASNLGIEIKALDENGHDLAV---TFPGPG-EDGLNPFLEVKVTDTP--------------------- 221 (335) T ss_pred EcHHHHHHHHHCCccCceEEEEEEeCCCCeEee---ecCCCC-CcccCcEEEEEecCCC--------------------- Confidence 9999999999986 789988775432 11111 111111 1234555555542110 Q NP_000548.2 372 YLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQT 451 (501) Q Consensus 372 ~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~ 451 (501) .++ +|. ....|........||+++++|+|+||||+ |||+|++|+||||.|.|+++.... ++|+. T Consensus 222 ----~~~-~r~----~~~~~~~~~~~~~Ccr~~l~V~F~~igW~-wIiaP~~y~a~~C~G~C~~~~~~~---~~~~~--- 285 (335) T 5NTU_A 222 ----KRS-RRD----FGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLAA---YPHTH--- 285 (335) T ss_pred ----ccc-ccc----CCCCCCCCCCCCCceeeEEEEEHHHcCCc-eeecCCeEEeEeeCccCCCCcccc---CCCch--- Confidence 111 111 10123233357899999999999999998 999999999999999999998642 24442 Q NP_000548.2 452 LMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 452 ~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++...+...+.|||+|++|++|+|||+|++++++++.++||+|++|||+ T Consensus 286 ~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~ 335 (335) T 5NTU_A 286 LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 335 (335) T ss_pred hHhccCCCCCCCCcccceeccceEEEEECCCCCEEEEEeCCceeeccccC Confidence 23333333578999999999999999999887889999999999999995 No 5 >5HLY_A Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; HET: MSE; 2.302A {Homo sapiens} Probab=100.00 E-value=3e-39 Score=332.69 Aligned_cols=307 Identities=21% Similarity=0.407 Sum_probs=167.2 Template_Neff=8.800 Q NP_000548.2 142 SSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKG------GN----SSVKLEAGLANTITSFIDKGQD 211 (501) Q Consensus 142 ~~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~------~~----~~~~~~~~~~n~Vrsf~~~~~~ 211 (501) =.+||++|||+++|+++.. . +.+..+..+|+.+....... .+ .+.+.+...++.|+.|.... T Consensus 40 K~~IL~kLgL~~~P~~~~~----~--p~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~t~~ii~f~~~~-- 111 (383) T 5HLY_A 40 KKHILNMLHLKKRPDVTQP----V--PKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESG-- 111 (383) T ss_dssp HHHHHHHTTCSSCCCCCCC----S--CHHHHHHHHHHTTSEEECGGGCEEETTCHHHHHHHHHHHHTEEEEEEECEEC-- T ss_pred HHHHHHHcCCCCCCCCCCC----C--CCHHHHHHHHHhhcCCCCCCCcccccCCCCCCCCccccccceeEEEEECcCC-- Confidence 3689999999999998752 1 11222234565443211000 00 00112223456666665432 Q NP_000548.2 212 DRGPVVRKQRYVFDISALE-K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR----------------- 272 (501) Q Consensus 212 ~~~~~~~~~~l~FnlSsi~-~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~----------------- 272 (501) .....++|++++.+ . +.|.+||||||+....... ......|.||...... T Consensus 112 -----~~~~~l~F~iS~~~~~~~~V~~AeL~l~~~~~~~~~------~~~~~~V~vy~~~~~~~~~~~~~~~~~~~~~~~ 180 (383) T 5HLY_A 112 -----TARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKG 180 (383) T ss_dssp -----SSTTEEEEHCCE-------EEEEEEEEEEECS----------------------------------SC----CEC T ss_pred -----CCeEEEEEEcCCCCCCcceeEEEEEEEEecCCCCCC------CCceEEEEEEEEecCCCCCCCCcchhHhhcCCc Confidence 13567899999754 2 4699999999998764320 1124567777543210 Q NP_000548.2 273 -QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWERGR-AVDLRGLGFDRAARQVHEKALFLVFGRT 348 (501) Q Consensus 273 -~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~~-~~~v~~~~~~~~~~~~~~~ppLLv~~~~ 348 (501) ....++.++.+ ....++|++||||.+|+.|+.++ +++|.|.+..... ...+ ...........+|+|++++.+ T Consensus 181 ~~~~~l~~s~~i-~~~~~gWi~fdVt~~V~~Wl~~~~~n~gl~v~~~~~~~~~~~l---~~~~~~~~~~~~P~Lvi~~~~ 256 (383) T 5HLY_A 181 ERSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASL---VLLGEEKEQSHRPFLMLQARQ 256 (383) T ss_dssp CEEEEEEEEEEE-ECSSCEEEEEECHHHHHHHHHTTCCEEEEEEECTTTTTTTCEE---ECSCCGGGGGGCCEEEEEEEC T ss_pred ccceEEEEEEEE-eCCCCcEEEEEcHHHHHHHHhCCccCcceEEEEEcCCCCCceE---EEecCCCccccccEEEEEEcC Confidence 00112333333 23457999999999999999987 7888877653221 1101 000011112356666666532 Q NP_000548.2 349 KKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFH 428 (501) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~y 428 (501) ... . +++++++ . ..| ......||+++++|+|+||||++|||+|++|+|+| T Consensus 257 ~~~----------------------~-~~rr~~~----~-~~~--~~~~~~Cc~~~~~V~F~~lgw~~wIiaP~~y~a~~ 306 (383) T 5HLY_A 257 SED----------------------H-PHRRRRR----G-LEC--DGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANY 306 (383) T ss_dssp C-------------------------------------C-CBC--SSCSSBCEEECCEEETTTTTCTTTEEECSEEECCE T ss_pred ccc----------------------c-ccccccc----C-CCC--CCCCcccccceeeecHHHhCCcceeecCCEEEcee Confidence 110 0 0111111 0 112 12468999999999999999988999999999999 Q NP_000548.2 429 CEGLCEFPLRSHLE--PTNHAVIQTLMNS--MDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 429 C~G~C~~~~~~~~~--~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |.|.|+.+.....+ .++|+.+...+.. ..+...+.|||+|++|++++|||+|++++++++.++||+|++|||+ T Consensus 307 C~G~C~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~ 383 (383) T 5HLY_A 307 CEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 383 (383) T ss_dssp EESBCC---------C---SCCC---------------CCCEEEEEEEEEEEEEES-SSCEEEEEEEEEEEEEEEEC T ss_pred ecccCCCCCCCCCCCcccHHHHHHHHHHhcCCCCCcCCCCcccccccCceEEEEEcCCCcEEEEEeCCcEEeecccC Confidence 99999998653211 1235433332211 1123568999999999999999999987889999999999999995 No 6 >6SF3_B Serine/threonine-protein kinase receptor R3 (E.C.2.7.11.30); BMP10, ALK1, complex, signalling, TGFbeta; 2.3000067422A {Homo sapiens} Probab=99.85 E-value=1.5e-26 Score=194.74 Aligned_cols=105 Identities=48% Similarity=1.049 Sum_probs=89.1 Template_Neff=8.600 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI 476 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i 476 (501) ...||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++| T Consensus 4 ~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~i 83 (108) T 6SF3_B 4 GNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISI 83 (108) T ss_dssp -CBSEEECCEEETTTTTGGGTEEECSEEECCEEESBBCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCBCEEEEEEEEEEE T ss_pred CCcceEEEeEeeHHHhCCCceeeCCCceeceeeccccCCCCCCCCCCCchHHHHHHHHhhCccccCCCcccceecCceEE Confidence 56899999999999999988999999999999999999987643334578877776654434467899999999999999 Q NP_000548.2 477 LFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 477 ly~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ||+++++.++.+.++||+|++|||+ T Consensus 84 l~~~~~~~~~~~~~~~~~v~~C~C~ 108 (108) T 6SF3_B 84 LYLDKGVVTYKFKYEGMAVSECGCR 108 (108) T ss_dssp EEEETTEEEEEEEEEEEEEEEEEEC T ss_pred EEEECCeeEEEEEECCeEEeecccC Confidence 9999875555678999999999995 No 7 >4MPL_A Growth/differentiation factor 2; growth factor/cytokine, CYTOKINE; 1.9A {Homo sapiens} Probab=99.84 E-value=2.3e-26 Score=196.32 Aligned_cols=106 Identities=50% Similarity=1.028 Sum_probs=90.4 Template_Neff=7.900 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++|++++ T Consensus 10 ~~~~C~~~~l~V~F~dlgw~~~Ii~P~~~~~~yC~G~C~~~~~~~~~~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 89 (116) T 4MPL_A 10 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 89 (116) T ss_dssp CCCCCEEECCEEETTTTTCTTTEEECSEEECCEEESCCCSSCCTTCCCCHHHHHHHHHHHHSTTTSCCCCEEEEEEEEEE T ss_pred CCCCCEEEEEEEeHHHhCCCCCeeCCCeeEeEEEcccCCCCCCCCCCCCchHHHHHHHhhcCCccCCCCceeeeEecCeE Confidence 35789999999999999998899999999999999999998765333457787777665443446789999999999999 Q NP_000548.2 476 ILFIDSANNVVYK-QYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~-~~~~mvv~~CgC~ 501 (501) |||+++++.++++ .++||+|++|+|+ T Consensus 90 ily~~~~~~~~~~~~~~~mvv~~CgC~ 116 (116) T 4MPL_A 90 VLYKDDMGVPTLKYHYEGMSVAECGCR 116 (116) T ss_dssp EEEECSSSCEEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEECCeEEeccccC Confidence 9999988666666 8999999999995 No 8 >6Z3J_B Growth/differentiation factor 5, RGM domain; Repulsive Guidance Molecule, RGM, Bone; HET: SO4, GOL, NAG, EDO; 1.65A {Homo sapiens} Probab=99.84 E-value=2.6e-26 Score=196.21 Aligned_cols=107 Identities=98% Similarity=1.618 Sum_probs=92.0 Template_Neff=8.300 Q NP_000548.2 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) .....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|+++ T Consensus 11 ~~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~~cC~P~~~~~l 90 (117) T 6Z3J_B 11 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 90 (117) T ss_dssp -CCCBSEEECCEEETTTTTGGGTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEE T ss_pred CCCCcceeEEEEEeHHHcCCCccEEcCCeeeceeeeecCCCCccccCCCChHHHHHHHHHhcCCCCCCCCcccceeecce Confidence 34789999999999999999889999999999999999999876433345788777766544445678999999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|+|+++++.++++.++||+|++|||+ T Consensus 91 ~ily~~~~~~~~~~~~~~~~v~~CgC~ 117 (117) T 6Z3J_B 91 SILFIDSANNVVKKDYEDMVVESCGCR 117 (117) T ss_dssp EEEEECTTSCEEEEEEEEEEEEEEEEC T ss_pred EEEEEcCCCcEEEEEECCeEEeeccCC Confidence 999999877788999999999999995 No 9 >5I05_A Growth/differentiation factor 2; GROWTH DIFFERENTIATION FACTOR 2, CELL; HET: GOL; 1.87A {Homo sapiens} Probab=99.84 E-value=4e-26 Score=192.88 Aligned_cols=106 Identities=50% Similarity=1.028 Sum_probs=90.1 Template_Neff=8.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++ T Consensus 4 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 83 (110) T 5I05_A 4 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 83 (110) T ss_dssp CCCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceeEEEEEeHHHhCCCCcEeCCCccccEeecCCCCCCCCCCCCCChhHHHHHHHhhcCCCCCCCcccceeeecceE Confidence 35789999999999999998899999999999999999998764333457777776655443456789999999999999 Q NP_000548.2 476 ILFIDSANNVVYK-QYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~-~~~~mvv~~CgC~ 501 (501) |||+|++++++++ .++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~~dm~v~~CgC~ 110 (110) T 5I05_A 84 VLYKDDMGVPTLKYHYEGMSVAECGCR 110 (110) T ss_dssp EEEECTTSCEEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEeCCeEEeecccC Confidence 9999998766666 8999999999995 No 10 >4N1D_A Bone morphogenetic protein 2; Cytokine, Signaling Protein; 1.912A {Homo sapiens} Probab=99.84 E-value=4.5e-26 Score=194.45 Aligned_cols=106 Identities=52% Similarity=1.077 Sum_probs=90.5 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|++++ T Consensus 11 ~~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 90 (116) T 4N1D_A 11 LKSSCKRHPLYVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCVPTELSAIS 90 (116) T ss_dssp -C-BSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceeEEEEEEHHHhCCCCCEeCCCeeeceeeeEeCCCCCccCCCCChhHHHHHHHHhcCCCCCCCCceecceecceE Confidence 46789999999999999998899999999999999999988764333457887777765444446789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++++.++++.++||+|.+|||+ T Consensus 91 il~~~~~~~~~~~~~~~~~v~~C~C~ 116 (116) T 4N1D_A 91 MLYLDENEKVVLKNYQDMVVEGCGCR 116 (116) T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEeCCeEEeccccC Confidence 99999877788999999999999995 No 11 >2QCQ_B Bone morphogenetic protein 3; BMP, TGF-beta, SIGNALING PROTEIN; 2.21A {Homo sapiens} Probab=99.83 E-value=5.7e-26 Score=191.87 Aligned_cols=105 Identities=46% Similarity=1.054 Sum_probs=89.3 Template_Neff=8.500 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-PESTPPTCCVPTRLSPIS 475 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~-~~~~~~pCC~P~~~~~l~ 475 (501) ...||+++++|+|+||||++|||+|++|+++||.|+|..+.....+.++|+.++.+++... ......|||+|++|++++ T Consensus 5 ~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~~CC~P~~~~~l~ 84 (110) T 2QCQ_B 5 PRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLS 84 (110) T ss_dssp CSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHSSCSTTCCCCCEEESSEEEEE T ss_pred CCcceeeEEEEeHHHhCCCcceeCCCeecceeeceeCCCCCCccCCCCcHHHHHHHHHHhCCCCCCCCCceeeEEeCceE Confidence 4689999999999999998899999999999999999998754333457777777655332 134679999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |||++++++++++.++||+|++|||+ T Consensus 85 il~~~~~~~~~~~~l~~~~v~~CgC~ 110 (110) T 2QCQ_B 85 ILFFDENKNVVLKVYPNMTVESCACR 110 (110) T ss_dssp EEEECTTCCEEEEEEEEEEECCEEEC T ss_pred EEEEcCCCcEEEEEECCeEEeccccC Confidence 99999887788899999999999995 No 12 >1LXI_A BONE MORPHOGENETIC PROTEIN 7; Cystine-knot growth factor, HORMONE-GROWTH FACTOR; HET: NAG; 2.0A {Homo sapiens} SCOP: g.17.1.2 Probab=99.83 E-value=9e-26 Score=198.70 Aligned_cols=111 Identities=48% Similarity=1.063 Sum_probs=90.2 Template_Neff=7.500 Q NP_000548.2 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470 (501) Q Consensus 391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~ 470 (501) +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++ T Consensus 29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~l~~~~~~~~~~~~CC~P~~ 108 (139) T 1LXI_A 29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ 108 (139) T ss_dssp -------CBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTCCCCCEEEEE T ss_pred cCCccccccceeeeeeccHHHhCCCCceecCCceeeeEecccCCCCcccccCCCHHHHHHHHHHhhCCCCCCCCceeeee Confidence 33445678999999999999999988999999999999999999887543234577777776654434467899999999 Q NP_000548.2 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |++++|||+++++.++++.++||+|++|||+ T Consensus 109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~ 139 (139) T 1LXI_A 109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH 139 (139) T ss_dssp EEEEEEEEECTTSCEEEEEEEEEEEEEEEEC T ss_pred eCceEEEEECCCCCEEEEEEcCeEEecccCC Confidence 9999999999877788999999999999995 No 13 >6OMN_G Bone morphogenetic protein 2; BMP, Bone Mophogenetic Protein, CYTOKINE; HET: BMA, MAN, NAG; 2.68A {Homo sapiens} Probab=99.83 E-value=9.8e-26 Score=189.80 Aligned_cols=105 Identities=57% Similarity=1.165 Sum_probs=89.4 Template_Neff=8.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++ T Consensus 4 ~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~ 82 (108) T 6OMN_G 4 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS 82 (108) T ss_pred CCCCcEEEEeEEehHHcCCCccEECCCeeeeEEEcccCCCCCccccCCCchHHHHHHHhcCC-CCCCCCceeEEeeCceE Confidence 35789999999999999998899999999999999999988654333456777776654432 35689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |||+++++.++++.++||+|++|||+ T Consensus 83 ily~~~~~~~~~~~~~~m~v~~CgC~ 108 (108) T 6OMN_G 83 MLYLDENEKVVLKNYQDMVVEGCGCR 108 (108) T ss_pred EEEECCCCcEEEEEeCCeEEeccccC Confidence 99999877788999999999999995 No 14 >2R53_A Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens} Probab=99.83 E-value=9.9e-26 Score=192.30 Aligned_cols=106 Identities=49% Similarity=1.068 Sum_probs=89.6 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~ 90 (116) T 2R53_A 11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS 90 (116) T ss_dssp CSSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCTTTTSCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE Confidence 36799999999999999998799999999999999999998654323456777666554433345789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++++.+++++++||+|++|||. T Consensus 91 il~~~~~~~~~~~~l~~~~v~~C~C~ 116 (116) T 2R53_A 91 VLYFDDNSNVILKKYRNMVVRACGCH 116 (116) T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEcCeEEecccCC Confidence 99999877788899999999999995 No 15 >2R53_B Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens} Probab=99.83 E-value=9.9e-26 Score=192.30 Aligned_cols=106 Identities=49% Similarity=1.068 Sum_probs=89.6 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~ 90 (116) T 2R53_B 11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS 90 (116) T ss_dssp CSSBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE Confidence 36799999999999999998799999999999999999998654323456777666554433345789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++++.+++++++||+|++|||. T Consensus 91 il~~~~~~~~~~~~l~~~~v~~C~C~ 116 (116) T 2R53_B 91 VLYFDDNSNVILKKYRNMVVRACGCH 116 (116) T ss_dssp EEEECTTSCEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEEcCeEEecccCC Confidence 99999877788899999999999995 No 16 >1REU_A bone morphogenetic protein 2; TGF-beta fold, HORMONE-GROWTH FACTOR COMPLEX; HET: MPD; 2.65A {Homo sapiens} SCOP: g.17.1.2 Probab=99.83 E-value=1.1e-25 Score=187.67 Aligned_cols=102 Identities=56% Similarity=1.151 Sum_probs=87.5 Template_Neff=8.600 Q NP_000548.2 399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF 478 (501) Q Consensus 399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily 478 (501) .||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++||| T Consensus 2 ~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~~i~~~~~~~~-~~~~~~cC~P~~~~~l~ily 80 (103) T 1REU_A 2 SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPPADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAISMLY 80 (103) T ss_dssp BSEEECCEEETTTTTCTTTCCBCSEEECCEEECBCCSSCCSSSCBCHHHHHHHHHHHHC-SSSCCCCEEEEEEEEEEEEE T ss_pred CceEEEeEecHHHcCCCCcEeCCCeecceEEeeeCCCCCcccCCCChhHHHHHHHhhcC-CCCCCccceeeEeCceEEEE Confidence 69999999999999998899999999999999999998754333456777776654332 35689999999999999999 Q NP_000548.2 479 IDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 479 ~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++++++++++.++||+|++|||+ T Consensus 81 ~~~~~~~~~~~~~~~~v~~CgC~ 103 (103) T 1REU_A 81 LDENEKVVLKNYQDMVVEGCGCR 103 (103) T ss_dssp ECTTCCEEEEEEEEEEEEEEEEC T ss_pred EcCCCcEEEEEeCCeEEeccccC Confidence 99877788999999999999995 No 17 >1M4U_L Bone Morphogenetic Protein-7/Noggin; NOGGIN, BMP ANTAGONIST, BMP-7, BONE; HET: NAG; 2.42A {Homo sapiens} SCOP: g.17.1.2 Probab=99.82 E-value=1.2e-25 Score=197.81 Aligned_cols=111 Identities=48% Similarity=1.063 Sum_probs=88.2 Template_Neff=7.500 Q NP_000548.2 391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR 470 (501) Q Consensus 391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~ 470 (501) +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++ T Consensus 29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~l~~l~~~~~~~~~~~pCC~P~~ 108 (139) T 1M4U_L 29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ 108 (139) T ss_dssp ---------SEEECCEEESGGGTCTTTEEECSEEECCEEECBCCSSEEGGGCCCHHHHHHHHHHHHCTTSSCCCCEEEEE T ss_pred ccCCCCCCcccceecccCHHHhCCCCceecCCeecceeecccCCCCCccccCCCHHHHHHHHHHhcCCCCCCCCceeeee Confidence 33445678999999999999999988999999999999999999887533234577777776654434467899999999 Q NP_000548.2 471 LSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |++++|||+++++.++++.++||+|++|||+ T Consensus 109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~ 139 (139) T 1M4U_L 109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH 139 (139) T ss_dssp EEEEEEEEECTTSCEEEEEEEEEEEEEEEES T ss_pred cCCeEEEEECCCCCEEEEEECCeEEeccccC Confidence 9999999999877788999999999999995 No 18 >2H62_B Bone morphogenetic protein 2, Bone; TGF-beta superfamily, ligand-receptor complex, HORMONE-GROWTH; 1.85A {Homo sapiens} SCOP: g.17.1.2 Probab=99.82 E-value=2.1e-25 Score=189.59 Aligned_cols=105 Identities=57% Similarity=1.165 Sum_probs=88.7 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... .....|||+|++|++++ T Consensus 10 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~ 88 (114) T 2H62_B 10 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS 88 (114) T ss_dssp --CBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHHC-TTSCCCCEEEEEEEEEE T ss_pred ccCcceEEEEEEehHHcCCCCcEeCCCeeeceEEeeeCCCCCccccCCCchHHHHHHHHhcC-CCCCCccceeeEeCceE Confidence 46789999999999999998899999999999999999988754333456777776654332 35689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+|++++++++.++||+|++|+|+ T Consensus 89 ily~~~~~~~~~~~~~~~~v~~C~C~ 114 (114) T 2H62_B 89 MLYLDENEKVVLKNYQDMVVEGCGCR 114 (114) T ss_dssp EEEEETTTEEEEEEEEEEEEEEEEEC T ss_pred EEEECCCCcEEEEEeCCeEEeccccC Confidence 99999877788999999999999995 No 19 >6Q2J_B Growth/differentiation factor 15, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 4.1A {Homo sapiens} Probab=99.81 E-value=3.8e-25 Score=193.68 Aligned_cols=102 Identities=27% Similarity=0.754 Sum_probs=85.9 Template_Neff=7.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+..+..|||+|++|++++ T Consensus 34 ~~~cC~~~~~~V~F~dlGw~~wIi~P~~~~~~~C~G~C~~~~~~---~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 110 (135) T 6Q2J_B 34 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 110 (135) T ss_pred CcCcceeEEEEEeHHHcCCCCcEECCCeEEeEEecccCCCCCCC---CChHHHHHHHHHhcCCCCCCCCceeeeeecceE Confidence 34445458999999999997799999999999999999988753 346777777665444456789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++ .++++.++||+|++|||+ T Consensus 111 ily~~~~-~i~~~~l~dmvv~~CgC~ 135 (135) T 6Q2J_B 111 LIQKTDT-GVSLQTYDDLLAKDCHCI 135 (135) T ss_pred EEEECCC-eEEEEEECCeEEeccccC Confidence 9998874 788899999999999995 No 20 >1KTZ_A TRANSFORMING GROWTH FACTOR BETA 3/TGF-beta; CYTOKINE-RECEPTOR COMPLEX, CYTOKINE-CYTOKINE RECEPTOR COMPLEX; 2.15A {Homo sapiens} SCOP: g.17.1.2 Probab=99.80 E-value=7.5e-25 Score=185.60 Aligned_cols=102 Identities=35% Similarity=0.837 Sum_probs=76.2 Template_Neff=8.200 Q NP_000548.2 395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP 473 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~ 473 (501) .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+...+.|||+|++|++ T Consensus 10 ~~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~ 85 (112) T 1KTZ_A 10 NLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEP 85 (112) T ss_dssp ---CCCEEECCEEECCCCCCCC-CEEECSEEECCEEECCCCSSCCC---------------------CCCCCEEECCEEE T ss_pred cccCCcEEEEEEEECchhcCCC-eeeCCCeeeeeeeeecCCCCCCC---CCChHHHHHHHHhcCcccCCCCcccceecCc Confidence 3478999999999999 99998 99999999999999999998753 3578877776654444567899999999999 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|||++++ .++++.++||+|++|||+ T Consensus 86 l~ily~~~~-~~~~~~~~~miv~~CgC~ 112 (112) T 1KTZ_A 86 LTILYYVGR-TPKVEQLSNMVVKSCKCS 112 (112) T ss_dssp EEEEEEETT-EEEEEEEEEEEECCEEEC T ss_pred eEEEEEeCC-eeEEEEecCeEEeeCcCC Confidence 999999987 577899999999999995 No 21 >5TY4_B TGF-beta receptor type-2 (E.C. 2.7.11.30); TRANSFERASE; 2.9A {Homo sapiens} Probab=99.80 E-value=9.9e-25 Score=179.89 Aligned_cols=96 Identities=34% Similarity=0.853 Sum_probs=84.4 Template_Neff=8.500 Q NP_000548.2 400 CSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF 478 (501) Q Consensus 400 Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily 478 (501) ||+++++|+|+ ++||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++|+| T Consensus 1 Cc~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~il~ 76 (97) T 5TY4_B 1 CCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIVY 76 (97) T ss_pred CeEEEEEEECccccCCC-ceeCCCcccCeeeceeCCCCCCC---CccHHHHHHHHHhcCcccCCCCceeceeccceeEEE Confidence 89999999997 99998 99999999999999999988653 457888777765444445789999999999999999 Q NP_000548.2 479 IDSANNVVYKQYEDMVVESCGC 500 (501) Q Consensus 479 ~d~~~~~~~~~~~~mvv~~CgC 500 (501) ++++ +++++.++||+|++||| T Consensus 77 ~~~~-~~~~~~~~~m~v~~CgC 97 (97) T 5TY4_B 77 YVGR-KPKVEQLSNMIVKSCKC 97 (97) T ss_pred EeCC-ceEEEEecCeEEeeCCC Confidence 9987 57889999999999999 No 22 >5VT2_B Growth/differentiation factor 15; TGF-beta family, SIGNALING PROTEIN; HET: EDO; 2.3A {Homo sapiens} Probab=99.80 E-value=1.1e-24 Score=184.58 Aligned_cols=102 Identities=27% Similarity=0.753 Sum_probs=87.2 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 87 (112) T 5VT2_B 11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 87 (112) T ss_dssp TTCBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE Confidence 34455569999999999998899999999999999999998753 457888877765544556789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++ +.+++++++||+|++|||. T Consensus 88 il~~~~-~~~~~~~~~~m~v~~C~C~ 112 (112) T 5VT2_B 88 LIQKTD-TGVSLQTYDDLLAKDCHCI 112 (112) T ss_dssp EEEECS-SSEEEEEEEEEEEEEEEEC T ss_pred EEEEcC-CeEEEEEeCCeEEecCCcC Confidence 999887 4788999999999999995 No 23 >5VZ3_A Growth/differentiation factor 15; Growth Factor, SIGNALING PROTEIN; 1.97A {Homo sapiens} Probab=99.80 E-value=1.1e-24 Score=184.58 Aligned_cols=102 Identities=27% Similarity=0.753 Sum_probs=87.2 Template_Neff=8.300 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....|++++++|+|+||||++|||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~ 87 (112) T 5VZ3_A 11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV 87 (112) T ss_dssp SSSBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE T ss_pred CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE Confidence 34455569999999999998899999999999999999998753 457888877765544556789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|+++ +.+++++++||+|++|||. T Consensus 88 il~~~~-~~~~~~~~~~m~v~~C~C~ 112 (112) T 5VZ3_A 88 LIQKTD-TGVSLQTYDDLLAKDCHCI 112 (112) T ss_dssp EEEECS-SSEEEEEEEEEEEEEEEEC T ss_pred EEEEcC-CeEEEEEeCCeEEecCCcC Confidence 999887 4788999999999999995 No 24 >2ARP_A Inhibin beta A chain, Follistatin; cystine knot, disulfide rich, egf; HET: GOL, 1PG; 2.0A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=81.5 Template_Neff=8.700 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501) ...||++.++|+|++|||++|||+|++|+++||.|.|..+..... ..++|+.++.++.. ..+.....|||+|++|+ T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116) T 2ARP_A 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116) T ss_dssp -CCSEEECCEEEHHHHTCTTTEEECSEEECCEEESCCCC-CCHHH----H----HHHHTTSTTCSSCCCCCCCEEEEEEE T ss_pred cccceeEEEEEeHHHcCCccceeCCCceeCceeeeeCCCCcCcCCCCCcchHHHHHHHHHhhCCCCCcCCCCcccccccC Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++|+|++++++++++.++||+|++|||+ T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116) T 2ARP_A 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116) T ss_dssp EEEEEEEC-TTCEEEEEEEEEEEEEEEEC T ss_pred ceEEEEEcCCCcEEEEEeCCeEEeecccC Confidence 99999999877788999999999999995 No 25 >2ARV_A Inhibin beta A chain; homodimer, cystine knot, disulfide linked; HET: 1PG, SO4, GOL; 2.0A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=86.7 Template_Neff=8.700 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501) ...||++.++|+|++|||++|||+|++|+++||.|.|+.+..... +.++|+.++.++.. ..+.....|||+|++|+ T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116) T 2ARV_A 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116) T ss_dssp CCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCGGGTTEETTEECHHHHHHHHHHHTTCTTTTTSCCCEEEEEEE T ss_pred cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++|||++++++++++.++||+|++|||+ T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116) T 2ARV_A 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116) T ss_dssp EEEEEEEETTTEEEEEEEEEEEEEEEEEC T ss_pred cEEEEEEeCCCeEEEEEeCCeEEeeccCC Confidence 99999999877788999999999999995 No 26 >2P6A_B Activin A, Follistatin 315; Follistatin, Activin,Inhibin, TGF-beta, SIGNALING PROTEIN; 3.4A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.3e-24 Score=184.92 Aligned_cols=105 Identities=38% Similarity=0.831 Sum_probs=86.7 Template_Neff=8.700 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~ 472 (501) ...||++.++|+|++|||++|||+|++|+++||.|.|+.+..... +.++|+.++.++.. ..+.....|||+|++|+ T Consensus 8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~ 87 (116) T 2P6A_B 8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR 87 (116) T ss_pred cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec Confidence 678999999999999999889999999999999999998865321 12456655554321 12335679999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++|||++++++++++.++||+|++|||+ T Consensus 88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~ 116 (116) T 2P6A_B 88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS 116 (116) T ss_pred cEEEEEEeCCCeEEEEEeCCeEEeeccCC Confidence 99999999877788999999999999995 No 27 >2TGI_A TRANSFORMING GROWTH FACTOR-BETA TWO (TGF-B2); GROWTH FACTOR; 1.8A {Homo sapiens} SCOP: g.17.1.2 Probab=99.79 E-value=1.5e-24 Score=183.69 Aligned_cols=101 Identities=35% Similarity=0.828 Sum_probs=88.1 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+.....|||+|++|+++ T Consensus 11 ~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l 86 (112) T 2TGI_A 11 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPL 86 (112) T ss_dssp CCSBSEEECCEEECCCCCCCT-TEEECSEEECCEEECBCCTTSSB---CSHHHHHHHHHHHHCGGGCCCCCEEECSEEEE T ss_pred CCCCcEEEEEEEECchhhCCc-eeeCCCeEeceeecccCCCCCCC---cccHHHHHHHHHhcCcccCCCCceeceeecce Confidence 478999999999999 99998 99999999999999999988653 34677777766544444678999999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|||++++ +++++.++||+|++|||+ T Consensus 87 ~il~~~~~-~~~~~~~~~m~v~~CgC~ 112 (112) T 2TGI_A 87 TILYYIGK-TPKIEQLSNMIVKSCKCS 112 (112) T ss_dssp EEEEEETT-EEEEEEEEEEEECCEEEC T ss_pred EEEEEeCC-ceEEEEeCCeEEEeCCCC Confidence 99999986 578899999999999995 No 28 >3HH2_B Growth/differentiation factor 8, Follistatin; protein-protein complex, TB domain, cystine; HET: PO4, CIT; 2.15A {Mus musculus} Probab=99.79 E-value=2.4e-24 Score=181.50 Aligned_cols=99 Identities=39% Similarity=0.949 Sum_probs=82.7 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|++|||+ |||+|++|+++||.|.|..+.... .+|+. +++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~ 83 (109) T 3HH2_B 11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN 83 (109) T ss_dssp CCCBSEEECCEEEHHHHTCT-TEEECSEEECCEEECBCCTTTTBC---CHHHH---HHHHHCCTTCCCCCEEEEEEEEEE T ss_pred CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE Confidence 46799999999999999998 999999999999999999987542 13332 222222235689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++++++++.++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~~m~v~~CgC~ 109 (109) T 3HH2_B 84 MLYFNGKEQIIYGKIPAMVVDRCGCS 109 (109) T ss_dssp EEEECTTCCEEEEEEEEEEEEEEEEC T ss_pred EEEEcCCCeEEEEEeCCeEEecccCC Confidence 99999877788999999999999995 No 29 >5F3B_C RK35 Chimeric antibody heavy chain; myostatin, antibody, complex, Signaling Protein-Immune; HET: GOL; 1.76A {Mus musculus} Probab=99.79 E-value=2.4e-24 Score=181.50 Aligned_cols=99 Identities=39% Similarity=0.949 Sum_probs=82.7 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|++|||+ |||+|++|+++||.|.|..+.... .+|+. +++...+.....|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~ 83 (109) T 5F3B_C 11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN 83 (109) T ss_pred CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE Confidence 46799999999999999998 999999999999999999987542 13332 222222235689999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++++++++.++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~~m~v~~CgC~ 109 (109) T 5F3B_C 84 MLYFNGKEQIIYGKIPAMVVDRCGCS 109 (109) T ss_pred EEEEcCCCeEEEEEeCCeEEecccCC Confidence 99999877788999999999999995 No 30 >3KFD_D Transforming growth factor beta-1, TGF-beta; TGF-beta, TGF-b1, TGF-beta receptor type-1; 2.995A {Homo sapiens} Probab=99.78 E-value=3.7e-24 Score=181.25 Aligned_cols=102 Identities=30% Similarity=0.731 Sum_probs=87.9 Template_Neff=8.300 Q NP_000548.2 395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP 473 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~ 473 (501) .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+... .++|+.++.+++...+..+..|||+|++|++ T Consensus 10 ~~~~~C~~~~~~v~f~~~lg~~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~~~~~~~~~~~~~~~~~~~~CC~P~~~~~ 85 (112) T 3KFD_D 10 STEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWSL---DTQYSKVLALYNQHNPGASAAPCCVPQALEP 85 (112) T ss_pred CCCCCcEEEEEEEECccccCCc-eeeCCCeEEeeeeceeCCCCCCC---cccHHHHHHHHHhhCCCCCCCCccccccccc Confidence 3477899999999998 99998 99999999999999999988653 3467777766654444467899999999999 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|+|++++ +++++.++||+|++|||+ T Consensus 86 l~ily~~~~-~~~~~~~~~m~v~~CgC~ 112 (112) T 3KFD_D 86 LPIVYYVGR-KPKVEQLSNMIVRSCKCS 112 (112) T ss_pred eeEEEEeCC-eEEEEEeCCeEEEecCCC Confidence 999999987 577899999999999995 No 31 >5E4G_A Growth/differentiation factor 11; Bone morphogenetic protein 11, BMP-11; HET: PG4; 1.5A {Homo sapiens} Probab=99.76 E-value=1.2e-23 Score=177.01 Aligned_cols=99 Identities=37% Similarity=0.939 Sum_probs=83.0 Template_Neff=8.400 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS 475 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ 475 (501) ....||+++++|+|+||||+ |||+|++|+++||.|+|..+.... .+|+.+ +....+..++.|||+|++|++++ T Consensus 11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~l---~~~~~~~~~~~~cC~P~~~~~l~ 83 (109) T 5E4G_A 11 SESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQK---YPHTHL---VQQANPRGSAGPCCTPTKMSPIN 83 (109) T ss_dssp CCCBSEEECCEEETTTTTCT-TEEECSEEECCEEECBCCTTTTCS---STHHHH---HHHHCCTTCCCCCEEEEEEEEEE T ss_pred CcCceEeEEEEEehHHcCCc-eEeCCCeeeceeecccCCcccccc---CCchHH---HHhcCCCCCCCCCccceeeccEE Confidence 47799999999999999998 999999999999999999987532 133322 11122345789999999999999 Q NP_000548.2 476 ILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 476 ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+|++++++++++.++||+|++|||+ T Consensus 84 il~~~~~~~~~~~~~~d~~v~~C~C~ 109 (109) T 5E4G_A 84 MLYFNDKQQIIYGKIPGMVVDRCGCS 109 (109) T ss_dssp EEEECSSSCEEEEEEEEEEEEEEEEC T ss_pred EEEEcCCCeEEEEEeCCeEEeeccCC Confidence 99999887888999999999999995 No 32 >5NMZ_B Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens} Probab=99.71 E-value=2.2e-22 Score=166.98 Aligned_cols=93 Identities=22% Similarity=0.465 Sum_probs=76.9 Template_Neff=8.300 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~ 472 (501) ...||+++++|+|+||||+ | |+|++|+++||.|.|..+.. +| +.++.+++... +.....|||+|++|+ T Consensus 4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~ 75 (101) T 5NMZ_B 4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE 75 (101) T ss_dssp CCBSEEEEEEEEGGGGTSS-C-CCCCEEEEEEEECBCGGGCC------HHHHHHHHHHTTTCSTTCCBCCSCCEEEEEEC T ss_pred CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec Confidence 5689999999999999999 8 89999999999999999864 23 33444433322 246789999999999 Q NP_000548.2 473 -PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++ |+|++ ++++.++||+|++|||+ T Consensus 76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101) T 5NMZ_B 76 DEVS--FLDAH--SRYHTVHELSARECACV 101 (101) T ss_dssp SEEE--EECTT--CCEEEEESCSEEEEEEC T ss_pred CceE--eecCC--cEEEEeCCeeeecccCC Confidence 999 77764 78899999999999995 No 33 >5NMZ_C Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens} Probab=99.71 E-value=2.2e-22 Score=166.98 Aligned_cols=93 Identities=22% Similarity=0.465 Sum_probs=76.9 Template_Neff=8.300 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~ 472 (501) ...||+++++|+|+||||+ | |+|++|+++||.|.|..+.. +| +.++.+++... +.....|||+|++|+ T Consensus 4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~ 75 (101) T 5NMZ_C 4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE 75 (101) T ss_dssp CCBSEEEEEEEEGGGGTSS-S-CCCCEEEEEEEECBCCTTSC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEEC T ss_pred CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec Confidence 5689999999999999999 8 89999999999999999864 23 33444433322 246789999999999 Q NP_000548.2 473 -PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++ |+|++ ++++.++||+|++|||+ T Consensus 76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101) T 5NMZ_C 76 DEVS--FLDAH--SRYHTVHELSARECACV 101 (101) T ss_dssp SCEE--EECTT--SCEEEESSCSEEEEEEC T ss_pred CceE--eecCC--cEEEEeCCeeeecccCC Confidence 999 77764 78899999999999995 No 34 >2GH0_C artemin, GDNF family receptor alpha-3; cystine-knot, helix bundle, HORMONE-GROWTH FACTOR; HET: BMA, NAG, MAN; 1.92A {Homo sapiens} Probab=99.71 E-value=2.9e-22 Score=166.00 Aligned_cols=95 Identities=19% Similarity=0.418 Sum_probs=77.9 Template_Neff=8.600 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD----PESTPPTCCVPTRLSP 473 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~----~~~~~~pCC~P~~~~~ 473 (501) ..||+++++|+|+||||++||| ++|+++||.|.|+.+.... .+.|+.++.++ ... ....+.|||+|++|++ T Consensus 2 ~~C~~~~~~V~f~dlgw~~~I~--~~~~~~~C~G~C~~~~~~~--~~~~~~l~~~~-~~~~~~~~~~~~~~CC~P~~~~~ 76 (101) T 2GH0_C 2 PGCRLRSQLVPVRALGLGHRSD--ELVRFRFCSGSCRRARSPH--DLSLASLLGAG-ALRPPPGSRPVSQPCCRPTRYEA 76 (101) T ss_pred CCCcceEEEEeHHHcCCCcccC--cEEecceeeeeCCCCCCCc--cchHHHHHHcc-cCCCCCCCCCCCCCceeeeeecc Confidence 4799999999999999988988 9999999999999987642 23455554443 111 1357899999999999 Q NP_000548.2 474 ISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 474 l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|||+++ +++.++||+|++|||+ T Consensus 77 l~il~~~~----~~~~~~~m~v~~CgC~ 100 (101) T 2GH0_C 77 VSFMDVNS----TWRTVDRLSATACGCL 100 (101) T ss_pred eEEEEeCC----eeEEEcceEeeccccc Confidence 99999875 5789999999999995 No 35 >5MR4_B Neurturin, GDNF family receptor alpha-2; Complex, Signalling, Receptor, signaling protein; 2.4A {Homo sapiens} Probab=99.70 E-value=4.4e-22 Score=165.39 Aligned_cols=94 Identities=21% Similarity=0.445 Sum_probs=76.5 Template_Neff=8.200 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRL 471 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~ 471 (501) ....||+++++|+|+||||+ | |+|++|+++||.|.|+.+.. +| +.++.++.... +.....|||+|++| T Consensus 4 ~~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~CC~P~~~ 75 (102) T 5MR4_B 4 GARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAY 75 (102) T ss_dssp -CCBSEEEEEEEEGGGGSSS-C-CCCCEEEEEEEESBCCSCCC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEE T ss_pred CCCCceeeEEEEEHHHcCCc-e-eCCCeEECeeeceeCCchhc------chHHHHHHHHHhhhhhccccCCCCceeeeee Confidence 35789999999999999998 7 89999999999999999864 23 33333333222 24678999999999 Q NP_000548.2 472 S-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) + +++ |+|++ ++++.++||+|++|||+ T Consensus 76 ~~~l~--y~d~~--~~~~~~~~m~v~~CgC~ 102 (102) T 5MR4_B 76 EDEVS--FLDAH--SRYHTVHELSARECACV 102 (102) T ss_dssp CCEEE--EECTT--SCEEEEESCSEEEEEEC T ss_pred cCceE--eecCC--cEEEEECCeeeccccCC Confidence 9 999 77764 78999999999999995 No 36 >2V5E_B GDNF FAMILY RECEPTOR ALPHA-1, GLIAL; RECEPTOR-GLYCOPROTEIN COMPLEX, CELL MEMBRANE, GROWTH; HET: NAG, EDO, SCR; 2.35A {RATTUS NORVEGICUS} Probab=99.69 E-value=7.4e-22 Score=163.65 Aligned_cols=93 Identities=24% Similarity=0.547 Sum_probs=77.2 Template_Neff=8.400 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRLS- 472 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~~- 472 (501) ...||+++++|+|+||||+ | |+|++|+++||.|.|+.+.. +| +.++.+++... +..+..|||+|++|+ T Consensus 5 ~~~C~~~~~~V~f~~lgw~-~-i~P~~~~~~~C~G~C~~~~~------~h~~~~~~l~~~~~~~~~~~~~~CC~P~~~~~ 76 (101) T 2V5E_B 5 NRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAET------TYDKILKNLSRNRRLVSDKVGQACCRPIAFDD 76 (101) T ss_dssp TTTCEEEEEEEEGGGGCSS-C-CCSCEEEEEEEESCCCSCCS------HHHHHHHHHHHTTSSSSSSTTCCCEEEEEECC T ss_pred CCcceeeEEEEEHHHcCCc-c-cCCCeEECceecEeCCCCCC------cHHHHHHHHHhccCCCcccCCCCeEEeeEecC Confidence 5689999999999999998 7 89999999999999999842 45 44554443321 345789999999999 Q NP_000548.2 473 PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +++ |+|++ ++++.++||+|++|||+ T Consensus 77 ~l~--y~d~~--~~~~~~~~m~v~~CgC~ 101 (101) T 2V5E_B 77 DLS--FLDDN--LVYHILRKHSAKRCGCI 101 (101) T ss_dssp CEE--EECTT--SCEEEECSCSEEEEEEC T ss_pred ceE--EecCC--EEEEEecCcEecccccC Confidence 999 77775 57899999999999995 No 37 >2ASK_B artemin; Glial cell derived family ligand; HET: SO4; 1.55A {Homo sapiens} Probab=99.69 E-value=9.1e-22 Score=166.60 Aligned_cols=94 Identities=20% Similarity=0.467 Sum_probs=77.2 Template_Neff=8.000 Q NP_000548.2 396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVP 468 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P 468 (501) ....||+++++|+|+||||+ | |+|++|+++||.|.|..+. ++| +.++.+++... ......|||+| T Consensus 12 ~~~~Cc~~~~~V~F~dlgw~-~-i~P~~~~~~~C~G~C~~~~------~~h~~~~~~l~~~~~~~~~~~~~~~~~~CC~P 83 (113) T 2ASK_B 12 GARGCRLRSQLVPVRALGLG-H-RSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRP 83 (113) T ss_dssp -CCBSEEEEEEEEGGGGSSS-C-CBSSEEEEEEEECBCGGGC------CHHHHHHHHHHHTTCSCCCSSSCCCCSCEEEE T ss_pred CCCCceeEEEEEEHHHcCCC-c-cCCCeEECceEeeeCCCCC------CCcHHHHHHHHHccCCCCCCCCCCCCCCceee Confidence 46799999999999999998 6 7999999999999999983 245 45555554332 23578999999 Q NP_000548.2 469 TRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 469 ~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ++|++++ |+|++ +++++++||+|++|||. T Consensus 84 ~~~~~l~--y~d~~--~~~~~l~~miv~~CgC~ 112 (113) T 2ASK_B 84 TRYEAVS--FMDVN--STWRTVDRLSATACGCL 112 (113) T ss_dssp EEEEEEE--EEBTT--SCEEEEEEEEEEEEEEE T ss_pred eEeceee--eecCC--cEEEEECCeEEeccccc Confidence 9999877 77775 67899999999999995 No 38 >3FUB_D GDNF family receptor alpha-1, Glial; GFRALPHA1, ALL ALPHA GDNF, CYSTINE; HET: NAG, EDO; 2.35A {Rattus norvegicus} Probab=99.69 E-value=9.6e-22 Score=171.18 Aligned_cols=96 Identities=24% Similarity=0.517 Sum_probs=80.0 Template_Neff=6.800 Q NP_000548.2 394 KNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSM--DPESTPPTCCVPTR 470 (501) Q Consensus 394 ~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~--~~~~~~~pCC~P~~ 470 (501) ......||++.++|+|+||||+ | |+|++|+++||.|.|.++. ++| ++++.+++.. .+..+..|||+|++ T Consensus 35 ~~~~~~Ccr~~l~V~F~dlGw~-~-iaP~~f~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~ 106 (134) T 3FUB_D 35 RGKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAE------TTYDKILKNLSRNRRLVSDKVGQACCRPIA 106 (134) T ss_pred CCCCCcceEEEEEEeHHHcCCC-c-cCCCeEEeEEeeCCCCCCc------chHHHHHHHHHHcCCCCCCCCCCCeeeeeE Confidence 3457899999999999999998 6 5999999999999999982 356 5666665543 12357899999999 Q NP_000548.2 471 LS-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 471 ~~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) |+ +++ |++++ + ++++++||+|++|||. T Consensus 107 ~~~~l~--y~d~~-~-~~~~l~~mvv~~CgC~ 134 (134) T 3FUB_D 107 FDDDLS--FLDDN-L-VYHILRKHSAKRCGCI 134 (134) T ss_pred eCCcee--EECCC-c-eEEEEcCeEEecccCC Confidence 99 988 77776 4 7899999999999995 No 39 >1AGQ_C GLIAL CELL-DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR, NEUROTROPHIC FACTOR, CYSTINE; 1.9A {Rattus norvegicus} SCOP: g.17.1.2 Probab=99.67 E-value=2.2e-21 Score=169.01 Aligned_cols=95 Identities=26% Similarity=0.544 Sum_probs=76.0 Template_Neff=6.700 Q NP_000548.2 395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRL 471 (501) Q Consensus 395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~ 471 (501) .....||++.++|+|+||||+ | |+|.+|+++||.|.|.++. ++| ++++.+++... +..+..|||+|++| T Consensus 37 ~~~~~Cc~~~l~V~F~dlGW~-i-iaP~~~~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~~ 108 (135) T 1AGQ_C 37 GKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCEAAE------TMYDKILKNLSRSRRLTSDKVGQACCRPVAF 108 (135) T ss_dssp ----CCEEEEEEEEGGGGCSC-C-CCCCEEEEEEEESCCCCCC------SHHHHHHHHHHHTTCC----CCCCCEEEEEE T ss_pred CCCCCceEEEEEEEHHHcCCC-c-cCCCeEEeEEecCCCCCCc------chHHHHHHHHHhhcCCCCcccCCCeeeeeee Confidence 457899999999999999998 5 8999999999999999972 367 66666655432 33578999999999 Q NP_000548.2 472 S-PISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) + +++ |++++ +++++++||+|++|||. T Consensus 109 ~~~l~--y~d~~--~~~~~l~dmiv~~CgC~ 135 (135) T 1AGQ_C 109 DDDLS--FLDDS--LVYHILRKHSAKRCGCI 135 (135) T ss_dssp CCCEE--EECSS--SCEEEECSCSEEEEEEC T ss_pred cCCee--eecCC--eEEEEEcCeEEecccCC Confidence 9 999 77765 47899999999999995 No 40 >5TX2_A Transforming growth factor beta-2; Growth factor, CYTOKINE; 1.82A {Mus musculus} Probab=99.66 E-value=2.9e-21 Score=157.69 Aligned_cols=81 Identities=33% Similarity=0.827 Sum_probs=74.0 Template_Neff=7.400 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) ....||+++++|+|+ ||||+ |||+|++|+++||.|.|..+. .+.+||+|++|+++ T Consensus 12 ~~~~C~~~~~~v~f~~dlgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~l 67 (93) T 5TX2_A 12 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL 67 (93) T ss_dssp CCSBSEEECCEEEHHHHHCCC-SEEECSEEECCEEECBCCCCS-----------------------SSCCCEEECCEEEE T ss_pred CCCCcEEEEEEEECchhcCCC-cEeCCCeEEcEEecccCCCCC-----------------------CCCCCceeceecce Confidence 478999999999999 99998 999999999999999998751 25799999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|||++++ +++++.++||+|++|||+ T Consensus 68 ~il~~~~~-~~~~~~l~~~~v~~CgC~ 93 (93) T 5TX2_A 68 TILYYIGN-TPKIEQLSNMIVKSCKCS 93 (93) T ss_dssp EEEEEETT-EEEEEEEEEEEECEEEEC T ss_pred EEEEEeCC-eEEEEEEcCcEEecCccC Confidence 99999986 578999999999999995 No 41 >5TX4_B TGF-beta receptor type-2 (E.C.2.7.11.30), Transforming; TGF-beta, TGF-beta type II receptor; 1.876A {Homo sapiens} Probab=99.66 E-value=3e-21 Score=157.29 Aligned_cols=81 Identities=31% Similarity=0.818 Sum_probs=74.3 Template_Neff=7.500 Q NP_000548.2 396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI 474 (501) Q Consensus 396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l 474 (501) ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+. .+.|||+|++|+++ T Consensus 11 ~~~~C~~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~~ 66 (92) T 5TX4_B 11 VQDNCCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL 66 (92) T ss_pred CCCCcEEEEEEEECchhcCCC-ceeCCCeEEcEEeeccCCCCC-----------------------CCCCceeccccCce Confidence 467999999999998 99998 999999999999999998752 25799999999999 Q NP_000548.2 475 SILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 475 ~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|||++++ +++++.++||+|++|+|+ T Consensus 67 ~il~~~~~-~i~~~~~~~~~v~~C~C~ 92 (92) T 5TX4_B 67 TIVYYVGR-KPKVEQLSNMIVKSCKCS 92 (92) T ss_pred eEEEEeCC-eeEEEEEcCeEEecCCCC Confidence 99999987 678999999999999995 No 42 >2GYZ_A neurotrophic factor artemin isoform 3; neurotrophic factor, cystine-knot, HORMONE-GROWTH FACTOR; 1.76A {Homo sapiens} Probab=99.57 E-value=1.4e-19 Score=150.88 Aligned_cols=89 Identities=18% Similarity=0.342 Sum_probs=71.6 Template_Neff=7.300 Q NP_000548.2 399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPTRL 471 (501) Q Consensus 399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~~~ 471 (501) .||+++++|+|+||||+ ||+|++|+++||.|+|..+.. ++ +.++.++.... +.....|||+|++| T Consensus 1 ~Cc~~~l~V~F~dlGw~--IiaP~~~~a~yC~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~~~pCC~P~~~ 72 (105) T 2GYZ_A 1 GCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRARS------PHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY 72 (105) T ss_dssp CCEEEEEEEEGGGGSSS--CCCSSEEEEEEEESCCGGGCC------HHHHHHHHHHHTTCSCCCSSSCCCSSCCCEEEEE T ss_pred CCeeEEEEEeHHHcCCc--cccCCceeceEEeccCCCCCC------chHHHHHHHHHhcCCCCCCCCCCCCCCeeeeeee Confidence 49999999999999998 899999999999999999853 22 23323332221 24578999999999 Q NP_000548.2 472 SPISILFIDSA-NNVVYKQYEDMVVES 497 (501) Q Consensus 472 ~~l~ily~d~~-~~~~~~~~~~mvv~~ 497 (501) ++++ |+|++ +.+++++++||+|.. T Consensus 73 ~~l~--y~d~~~~~i~~~~lp~m~~~~ 97 (105) T 2GYZ_A 73 EAVS--FMDVNSTWRTVDRLSATACGC 97 (105) T ss_dssp EEEE--EECTTSCEEEEEEEEEEEEEC T ss_pred ceee--EEeCCCCeEEEEEeccceeec Confidence 9999 88876 578899999999875 No 43 >6Q2S_B Ubiquitin-like protein SMT3,Artemin, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 3.8A {Saccharomyces cerevisiae} Probab=99.47 E-value=2.9e-18 Score=163.18 Aligned_cols=93 Identities=20% Similarity=0.483 Sum_probs=77.2 Template_Neff=8.400 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPT 469 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~ 469 (501) ...||++.++|+|++|||+ ||+|.+|+++||.|.|..+. ++| +.++.+++... ......|||+|+ T Consensus 135 ~~~C~~~~~~V~f~~lgw~--ii~P~~~~~~~C~G~C~~~~------~~~~~~~~~l~~~~~~~~~~~~~~~~~~CC~P~ 206 (235) T 6Q2S_B 135 ARGCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRPT 206 (235) T ss_pred CceeeeecCccchHHcCCe--eecCCeEECccccCCCCCCC------CCHHHHHHHHHHcCCCCCCCCCCCCCCCccCce Confidence 5789999999999999998 58999999999999999983 255 45555554332 135789999999 Q NP_000548.2 470 RLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 470 ~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) +|++++ |++++ +++++++||+|++|||+ T Consensus 207 ~~~~l~--y~~~~--~~~~~~~~m~v~~CgC~ 234 (235) T 6Q2S_B 207 RYEAVS--FMDVN--STWRTVDRLSATACGCL 234 (235) T ss_pred ecCeee--eecCC--eEEEEeCCcEEeccccc Confidence 999988 77764 67899999999999995 No 44 >6GFF_E Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: BMA, MAN, NAG; 3.1A {Mus musculus} Probab=98.95 E-value=1.1e-13 Score=131.10 Aligned_cols=158 Identities=22% Similarity=0.234 Sum_probs=101.3 Template_Neff=9.700 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|+++.. .+.+++++|++||+.+......... ..+.+....+++|++|......... . T Consensus 22 ~~IL~~Lgl~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 97 (249) T 6GFF_E 22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 97 (249) T ss_pred HHHHHHcCCCCCCCCCCC----CCCCccHHHHHHHHhhhccccCCCCCcccCCcccchhcccceeeeecCCCCCCCcccC Confidence 689999999999998651 1245689999999987665321100 0111223456788888654332100 1 Q NP_000548.2 216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|++++++ . +.|.+|+||||+..... ...|.||...... ...++..+.+.....++ T Consensus 98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~ 165 (249) T 6GFF_E 98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE 165 (249) T ss_pred CCCcEEEEEecccCCCCCCCccceEEEEEEEEeCCCCC-----------cEEEEEEEecCCC-ceeEEEEEEeecCCCCc Confidence 234677999999742 2 47999999999987642 3566777643210 11123333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|.|.+. T Consensus 166 W~~~dvt~~v~~W~~~~~~n~gl~v~v~ 193 (249) T 6GFF_E 166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH 193 (249) T ss_pred eEEEEcHHHHHHHHhCCcccceEEEEEE Confidence 99999999999999986 788886554 No 45 >6GFF_G Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: MAN, NAG, BMA; 3.1A {Mus musculus} Probab=98.95 E-value=1.1e-13 Score=131.18 Aligned_cols=158 Identities=22% Similarity=0.234 Sum_probs=101.5 Template_Neff=9.600 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P 215 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~ 215 (501) .+||++|||+++|++... .+.+++++|++||+.+......... ..+.+....+++|++|......... . T Consensus 22 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~ 97 (249) T 6GFF_G 22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ 97 (249) T ss_dssp HHHHHHTTCSSCCCSTTC----CSSSCCHHHHHHHHHHHSCCCCC-------CGGGTSCEEEEEEECCCCCCCCHHHSCC T ss_pred HHHHHHcCCCCCCCCCCC----CCCCChHHHHHHHHHHHhhccCCCCCCCCCChhhhhhheeEeeEEeeccccccccccc Confidence 689999999999998651 2235689999999987655321100 0111223456788887654332100 1 Q NP_000548.2 216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG 290 (501) Q Consensus 216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g 290 (501) ......+.|++++++ . +.|.+|+||||+..... ...|.||...... ...++..+.+.....++ T Consensus 98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~ 165 (249) T 6GFF_G 98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE 165 (249) T ss_dssp CTTEEEEEEEHHHHHHHSSSGGGEEEEEEEEEECCBSS-----------CEEEEEEECCSSS-CCEEEEEEEECCBSSCE T ss_pred CCCcEEEEeehHHhhccCCCcceEEEEEEEEEEcCCCc-----------eEEEEEEEecCCC-ceeEeEEEEeCCCCCCC Confidence 234677999999752 2 47999999999987642 3567777643210 11123333221234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA--QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|.|.+. T Consensus 166 W~~~dVt~~v~~W~~~~~~n~~l~v~v~ 193 (249) T 6GFF_G 166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH 193 (249) T ss_dssp EEEEECHHHHHHHHHSCCSEEEEEEEEC T ss_pred eEEEEhHHHHHHHHHcCCCccCEEEEEE Confidence 99999999999999987 788886554 No 46 >5HLZ_E Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; 2.851A {Homo sapiens} Probab=98.74 E-value=1.8e-12 Score=124.55 Aligned_cols=155 Identities=15% Similarity=0.223 Sum_probs=99.6 Template_Neff=9.000 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG------N----SSVKLEAGLANTITSFIDKGQDD 212 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~------~----~~~~~~~~~~n~Vrsf~~~~~~~ 212 (501) .+||++|||+.+|+++.. .+ .+++|++||+.+........ + ..++.....+++|++|.+.+. T Consensus 41 ~~IL~~LGl~~~P~~~~~----~~--~p~~M~~LY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~I~sf~~~~~-- 112 (270) T 5HLZ_E 41 KHILNMLHLKKRPDVTQP----VP--KAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGT-- 112 (270) T ss_pred HHHHHHcCCCCCCCCCCC----CC--hHHHHHHHHHhhcCcccCCCceeccccccchhhhhhhhcceEEEEEEecCCC-- Confidence 689999999999998651 11 38999999998765442100 0 001123345678888876532 Q NP_000548.2 213 RGPVVRKQRYVFDISA-LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR------------------ 272 (501) Q Consensus 213 ~~~~~~~~~l~FnlSs-i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~------------------ 272 (501) ....+.|+++. .+. +.|.+|+||||+....... ......+.||...... T Consensus 113 -----~~~~l~F~~s~~~~~~~~v~~AeL~l~~~~~~~~~------~~~~~~i~vy~~~~~~~~~~~~~~~~~~~g~~~~ 181 (270) T 5HLZ_E 113 -----ARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGE 181 (270) T ss_pred -----ccEEEEEEecCCCCCceeEEEEEEEEEEeCCCcCC------CcceEEEEEEEEeeCCCCCCCCCchhhhhcCCcc Confidence 34578999987 433 4699999999998764310 1124566777543210 Q NP_000548.2 273 QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWE 317 (501) Q Consensus 273 ~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~ 317 (501) ....++.++.+ .....+|++|||+.+|+.|+..+ +++|.|.+.. T Consensus 182 ~~~~ll~s~~v-~~~~~gW~~fdVt~~v~~W~~~~~~n~gl~v~~~~ 227 (270) T 5HLZ_E 182 RSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQ 227 (270) T ss_pred ceEEEEEEEEe-ecCCCceEEEEChHHHHHHHHcCCCCeeEEEEEEe Confidence 01112333333 23457999999999999999986 7898887754 No 47 >4YCG_B pro-BMP9 prodomain, human BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: NAG, ZN; 3.3A {Mus musculus} Probab=98.69 E-value=3.5e-12 Score=124.35 Aligned_cols=152 Identities=18% Similarity=0.323 Sum_probs=81.5 Template_Neff=8.500 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR 218 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~ 218 (501) .+||++|||.++|++... ...+++||++||+.+...... ...+++|++|.+....... .... T Consensus 41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~ 106 (296) T 4YCG_B 41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ 106 (296) T ss_dssp -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE T ss_pred HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC Confidence 589999999999997641 124589999999987655321 1245677777654332110 0124 Q NP_000548.2 219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG 290 (501) Q Consensus 219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g 290 (501) ...+.|+++ ++. +.|..|+||||+........ .......|.||....... ...++... .....+ T Consensus 107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g 178 (296) T 4YCG_B 107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG 178 (296) T ss_dssp EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTG----GGCCCEEEEEEEEEECCSSCSSSSSEEEEEEEE---EECSSE T ss_pred cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe Confidence 567899998 653 68999999999887643110 011245677776432100 01112222 234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA----QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|+|.+. T Consensus 179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~ 208 (296) T 4YCG_B 179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ 208 (296) T ss_dssp EEEEECHHHHHHHHSCCSSSCCSEEEEEEE T ss_pred eEEEEhHHHHHHHHHCCCCCCCceEEEEEE Confidence 99999999999999985 478887664 No 48 >4YCI_B mouse pro-BMP9 prodomain, pro-BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: ZN, NAG; 3.25A {Mus musculus} Probab=98.69 E-value=3.5e-12 Score=124.35 Aligned_cols=152 Identities=18% Similarity=0.323 Sum_probs=81.5 Template_Neff=8.500 Q NP_000548.2 143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR 218 (501) Q Consensus 143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~ 218 (501) .+||++|||.++|++... ...+++||++||+.+...... ...+++|++|.+....... .... T Consensus 41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~ 106 (296) T 4YCI_B 41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ 106 (296) T ss_dssp -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE T ss_pred HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC Confidence 589999999999997641 124589999999987655321 1245677777654332110 0124 Q NP_000548.2 219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG 290 (501) Q Consensus 219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g 290 (501) ...+.|+++ ++. +.|..|+||||+........ .......|.||....... ...++... .....+ T Consensus 107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g 178 (296) T 4YCI_B 107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG 178 (296) T ss_dssp EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTC----TTCCCEEEEEEEEEECCSSCSTTSSEEEEEEEE---EECSSE T ss_pred cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe Confidence 567899998 653 68999999999887643110 011245677776432100 01112222 234579 Q NP_000548.2 291 WEVFDIWKLFRNFKNSA----QLCLELEAW 316 (501) Q Consensus 291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~ 316 (501) |+.||||.+|+.|+.++ +++|+|.+. T Consensus 179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~ 208 (296) T 4YCI_B 179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ 208 (296) T ss_dssp EEEEECHHHHHHHHSCTTSSCCSEEEEEEE T ss_pred eEEEEhHHHHHHHHHCCCCCCCceEEEEEE Confidence 99999999999999985 478887664 No 49 >4NT5_A von Willebrand factor; cystine knot, dimerization of VWF; HET: SO4, NAG; 3.281A {Homo sapiens} Probab=75.72 E-value=0.27 Score=37.97 Aligned_cols=65 Identities=22% Similarity=0.456 Sum_probs=39.6 Template_Neff=7.800 Q NP_000548.2 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..+..++|.|.|...... +... . .....-.||.|.++....|...=.+|.. ..+.=+++.+|+|. T Consensus 37 ~~v~~~~C~G~C~S~~~~-----~~~~--~------~~~~~c~CC~p~~~~~~~v~L~C~~g~~--~~~~~~~i~~C~C~ 101 (107) T 4NT5_A 37 VEVDIHYCQGKCASKAMY-----SIDI--N------DVQDQCSCCSPTRTEPMQVALHCTNGSV--VYHEVLNAMECKCS 101 (107) T ss_dssp SCEEEEECCCBCCEEEEE-----ETTT--T------EEEEEEEEEEESSEEEEEEEEECTTSCE--EEEEEEEECCEEEE T ss_pred eeeeceEEeEeecCceee-----cCCc--c------ceEeecCcccCeEeEeEEEEEECCCCCE--EEEEEEeeeeceEE Confidence 567889999999875321 1100 0 0123578999999987776444333332 23344678899994 No 50 >2KD3_A Sclerostin; Protein, antagonist of CYTOKINE, PROTEIN; NMR {Mus musculus} Probab=73.48 E-value=0.35 Score=38.01 Aligned_cols=73 Identities=15% Similarity=0.291 Sum_probs=40.9 Template_Neff=6.600 Q NP_000548.2 419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANN-VVYKQYEDMVVES 497 (501) Q Consensus 419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~-~~~~~~~~mvv~~ 497 (501) ++.+.+...+|.|.|....... ...... ... . ......||.|.++....|.+.=.+|. .+ ...-+.|.+ T Consensus 39 ~S~~~v~~~~C~G~C~s~s~~~---~~~~~~-~~~-~---~~~~c~CC~p~~t~~r~V~l~C~dG~~~~--~~~~~~V~~ 108 (113) T 2KD3_A 39 RSAKPVTELVCSGQCGPARLLP---NAIGRV-KWW-R---PNGPDFRCIPDRYRAQRVQLLCPGGAAPR--SRKVRLVAS 108 (113) T ss_dssp EECCCCCBCCCCCCCSCCCCCC---CCTTCC-SSS-C---SSCCCCCCEEEEEEEEEEEEECTTSEE------EEEEEEE T ss_pred eeCCccccceeeeeCCCCccCC---cccCCC-Ccc-c---ccCCCccccCceeEEEEEEEECCCCCeeE--EEEeEEEee Confidence 4456678889999998653210 000000 000 0 12357899999999877655433342 22 334468899 Q NP_000548.2 498 CGCR 501 (501) Q Consensus 498 CgC~ 501 (501) |+|. T Consensus 109 C~C~ 112 (113) T 2KD3_A 109 CKCK 112 (113) T ss_dssp EECC T ss_pred cccC Confidence 9994 No 51 >4YU8_A Neuroblastoma suppressor of tumorigenicity 1; BMP Binding Protein, NBL1 DAN; HET: NAG; 1.8A {Homo sapiens} Probab=70.00 E-value=0.48 Score=38.53 Aligned_cols=88 Identities=13% Similarity=0.121 Sum_probs=41.4 Template_Neff=7.100 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=| - . +..+..++|.|.|....... ... ... .....-.||.|.++....|- T Consensus 32 ~~C~~~~~~~~I~~~g---C-~-s~~V~~~~C~G~C~S~s~~~----~~~---~~~----~~~~~CsCC~p~~~~~~~V~ 95 (139) T 4YU8_A 32 AWCEAKNITQIVGHSG---C-E-AKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT 95 (139) T ss_dssp CEEEEEEEEEEECCTT---S-C-CEEEEEEEEEEECCC------------------------------EEEEEEEEEEEE T ss_pred CccEEEeeEEEEecCC---c-e-eeeeecceeeceecccccCC----CCC---CCc----cceeecCcccCeEEEEEEEE Confidence 3566555444443211 1 2 25678899999998753210 000 000 01123469999999977664 Q NP_000548.2 478 FIDSANNV-VYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~-~~~~~~~mvv~~CgC~ 501 (501) ..=.++.. ....+.=..+.+|+|. T Consensus 96 L~C~~g~~~~~~~~~~~~v~sC~C~ 120 (139) T 4YU8_A 96 LECPGHEEVPRVDKLVEKILHCSCQ 120 (139) T ss_dssp EECTTCSSSCEEEEEEEEEEEEEEC T ss_pred EeCCCCCCcccEEEEEEeeeecccc Confidence 33233322 0022333478999995 No 52 >2K8P_A Sclerostin; WNT SIGNALLING PATHWAY, BONE FORMATION; NMR {Homo sapiens} Probab=66.67 E-value=0.66 Score=39.89 Aligned_cols=74 Identities=18% Similarity=0.288 Sum_probs=43.0 Template_Neff=5.300 Q NP_000548.2 419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESC 498 (501) Q Consensus 419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~C 498 (501) .+.+.+...+|.|.|...... .+.. -...... ......||+|.+.....|-+.=.+|. ....+.-|+|.+| T Consensus 71 ~S~kpV~~~~C~G~C~~~s~~----~~~~-~~~k~~~---~~~~~~CC~P~rTrtrrV~f~C~DGt-~t~~~~v~~V~sC 141 (189) T 2K8P_A 71 RSAKPVTELVCSGQCGPARLL----PNAI-GRGKWWR---PSGPDFRCIPDRYRAQRVQLLCPGGE-APRARKVRLVASC 141 (189) T ss_dssp EESSCEEEEEECCCCCCCCCC----SSCC-CSSCCCS---CCCCCCCCEECCEEEEEEEEECCTTS-CCEEEEEEEECCE T ss_pred ecCCceeeeEEeeeCCCcccC----CCcc-cCCCccC---CCCCCCCCCCCeeEEEEEEEECCCCC-cceeEEeeEeeeC Confidence 556777889999999864321 0100 0000001 12357899999988766655434342 0123345789999 Q NP_000548.2 499 GCR 501 (501) Q Consensus 499 gC~ 501 (501) +|. T Consensus 142 kCk 144 (189) T 2K8P_A 142 KCK 144 (189) T ss_dssp ECC T ss_pred CCc Confidence 994 No 53 >4JPH_D Gremlin-2; Cystine knot, DAN domain, CAN; HET: GSH, GOL, CIT; 2.25A {Mus musculus} Probab=65.08 E-value=0.72 Score=37.91 Aligned_cols=88 Identities=14% Similarity=0.239 Sum_probs=48.1 Template_Neff=6.700 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=|= .+ ..+..++|.|.|....... ....... ....-.||.|.++....|. T Consensus 51 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~p~----~~~~~~~-------~~~~CsCC~p~~~~~~~V~ 114 (148) T 4JPH_D 51 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE 114 (148) T ss_dssp CEEEEEEEEEEECCTTS----CC-EEEEEEEEEEEEEEEEEEC----CCSSSCC-------EEEEEEEEEEEEEEEEEEE T ss_pred CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE Confidence 45776666555442221 22 4678899999998643210 0000000 1234689999999976664 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..=.++.-......=..|.+|+|. T Consensus 115 L~C~~g~~~~~~~~v~~V~sC~C~ 138 (148) T 4JPH_D 115 LECPGLDPPFRIKKIQKVKHCRCM 138 (148) T ss_dssp ECCTTSSSSCEEEEEEEEEEEEEE T ss_pred EeCCCCCCCceEEEEEeeeeCcee Confidence 332222211122334588999995 No 54 >4X1J_B Neuroblastoma suppressor of tumorigenicity 1; BMP antagonist, DAN family, Cystine-knot; HET: NAG; 2.5A {Homo sapiens} Probab=64.18 E-value=0.74 Score=35.85 Aligned_cols=88 Identities=13% Similarity=0.131 Sum_probs=46.1 Template_Neff=7.700 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=|= .+..+..++|.|.|....... ... ... .....-.||.|.++....|. T Consensus 17 ~~C~~~~~~~~i~~~gC-----~s~~i~~~~C~G~C~S~~~~~----~~~---~~~----~~~~~C~CC~p~~~~~~~V~ 80 (116) T 4X1J_B 17 AWCEAKNITQIVGHSGC-----EAKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT 80 (116) T ss_dssp CEEEEEEEEEEECCTTS-----CCEEEEEEEEEEEEEEEECC------------------CTTEEEEEEEEEEEEEEEEE T ss_pred CccEEEEeEEEEccCCc-----cceeEecceEeeeeeeeeecC----CCC---CCC----cceeecCCccceEEEEEEEE Confidence 35666555444432111 123578899999998643210 000 000 01234579999999987764 Q NP_000548.2 478 FIDSANNV-VYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~-~~~~~~~mvv~~CgC~ 501 (501) ..=.++.- ......=.++.+|+|. T Consensus 81 L~C~~g~~~~~~~~~~~~v~~C~C~ 105 (116) T 4X1J_B 81 LECPGHEEVPRVDKLVEKILHCSCQ 105 (116) T ss_dssp EECTTCSSSSEEEEEEEEEEEEEEE T ss_pred EECCCCCCCccEEEEEEeeEecccc Confidence 43233322 1122333478999995 No 55 >5AEJ_A GREMLIN-1; SIGNALING PROTEIN, SIGNALING, GREMLIN, GROWTH; HET: SO4; 1.904A {HOMO SAPIENS} Probab=62.64 E-value=0.87 Score=37.64 Aligned_cols=87 Identities=15% Similarity=0.248 Sum_probs=48.6 Template_Neff=6.100 Q NP_000548.2 397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI 476 (501) Q Consensus 397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i 476 (501) ...|....+...+..=|= . +..+..++|.|.|...... ... . .. . .....-.||.|.++....| T Consensus 59 ~~~C~~~~~~q~I~~~gC----~-S~~V~~~~C~G~C~S~s~p-----s~~-~-~~---~-~~~~~CsCC~p~~s~~~~V 122 (152) T 5AEJ_A 59 RDWCKTQPLKQTIHEEGC----N-SRTIINRFCYGQCNSFYIP-----RHI-R-KE---E-GSFQSCSFCKPKKFTTMMV 122 (152) T ss_dssp CCEEEEEEEEEEECCTTS----C-CEEEEEEEEEEEEEEEEEE-----EEE-T-TE---E-EEEEEEEEEEEEEEEEEEE T ss_pred CCceeeeeceeEEccCCc----e-eceEEeeeceeecccCeec-----ccc-c-cc---C-CceeecCcccceEEEEEEE Confidence 456877766555542221 2 2568899999999864321 100 0 00 0 0122467999999987666 Q NP_000548.2 477 LFIDSANNV--VYKQYEDMVVESCGCR 501 (501) Q Consensus 477 ly~d~~~~~--~~~~~~~mvv~~CgC~ 501 (501) ...=.++.. +.+.+ ..+.+|.|. T Consensus 123 ~L~Cpdg~~~~~~~~v--~~V~sC~C~ 147 (152) T 5AEJ_A 123 TLNCPELQPPTKKKRV--TRVKQCRCI 147 (152) T ss_dssp EEECTTSSSSEEEEEE--EEEEEEEEE T ss_pred EEECCCCCCCceEEEE--EeceeceeE Confidence 333222322 23333 578999995 No 56 >5HK5_G Gremlin-2, Growth/differentiation factor 5; DAN-family, Bone Morphogenetic Proteins, CYTOKINE; 2.9A {Mus musculus} Probab=61.90 E-value=0.91 Score=37.23 Aligned_cols=86 Identities=15% Similarity=0.240 Sum_probs=46.5 Template_Neff=6.600 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=|= .+ ..+..++|.|.|....... ....... ....-.||.|.++....|. T Consensus 50 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~ps----~~~~~~~-------~~~~CsCC~p~~~~~~~V~ 113 (147) T 5HK5_G 50 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE 113 (147) T ss_pred CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE Confidence 35665555544432121 22 4578899999998643210 0000000 1234679999999976663 Q NP_000548.2 478 FIDSANNV--VYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~--~~~~~~~mvv~~CgC~ 501 (501) ..=.++.. +.+. =.+|.+|+|. T Consensus 114 L~C~dg~~~~~~~~--~~~V~sC~C~ 137 (147) T 5HK5_G 114 LECPGLDPPFRIKK--IQKVKHCRCM 137 (147) T ss_pred EeCCCCCCCceEEE--EEeeeeCcee Confidence 33222221 2333 3578999994 No 57 >5BPU_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: GGL; 2.4A {Homo sapiens} Probab=57.82 E-value=1.2 Score=34.98 Aligned_cols=72 Identities=21% Similarity=0.280 Sum_probs=38.3 Template_Neff=7.700 Q NP_000548.2 422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..+..++|.|.|....... ........ ........-.||.|.++....+...=.++..+. ..-.++.+|.|. T Consensus 37 ~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~v~l~C~~g~~~~--~~~~~i~~C~C~ 108 (122) T 5BPU_A 37 KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLT--ATYRYILSCHCE 108 (122) T ss_pred CcEeceeeeccccceeecC----CCcccCCC--CCCcceeeeecCcCeEeEEEEEEEECCCCCeEE--EEEEEEEeceee Confidence 6678899999998753200 00000000 000012345899999988766533323332222 333478899994 No 58 >5BQ8_C Norrin; Wnt signalling pathway, Norrie disease; HET: MLY; 2.0A {Homo sapiens} Probab=53.96 E-value=1.5 Score=34.27 Aligned_cols=93 Identities=19% Similarity=0.268 Sum_probs=46.5 Template_Neff=7.800 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=.. .- .. ..+..++|.|.|....... ........ ........-.||.|.++....|. T Consensus 16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~ 86 (122) T 5BQ8_C 16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR 86 (122) T ss_dssp TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCEETTB--CCCSEEEECEEEEEEEEEEEEEE T ss_pred CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE Confidence 45666555444432100 11 22 6678899999998753200 00000000 00001234589999998876653 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..=.++..+ ...-+++.+|.|. T Consensus 87 l~C~~g~~~--~~~~~~i~~C~C~ 108 (122) T 5BQ8_C 87 LRCSGGMRL--TATYRYILSCHCE 108 (122) T ss_dssp EEETTTEEE--EEEEEEEEEEEEE T ss_pred EECCCCceE--EEEEEEEEeceee Confidence 332333322 2334578999994 No 59 >5BQE_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: MLY, NAG, PG0; 2.3A {Homo sapiens} Probab=53.96 E-value=1.5 Score=34.27 Aligned_cols=93 Identities=19% Similarity=0.268 Sum_probs=46.5 Template_Neff=7.800 Q NP_000548.2 398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL 477 (501) Q Consensus 398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il 477 (501) ..|....+...+..=.. .- .. ..+..++|.|.|....... ........ ........-.||.|.++....|. T Consensus 16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~ 86 (122) T 5BQE_A 16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR 86 (122) T ss_dssp TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCBCSSS--CSSCEEEECEEEEEEEEEEEEEE T ss_pred CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE Confidence 45666555444432100 11 22 6678899999998753200 00000000 00001234589999998876653 Q NP_000548.2 478 FIDSANNVVYKQYEDMVVESCGCR 501 (501) Q Consensus 478 y~d~~~~~~~~~~~~mvv~~CgC~ 501 (501) ..=.++..+ ...-+++.+|.|. T Consensus 87 l~C~~g~~~--~~~~~~i~~C~C~ 108 (122) T 5BQE_A 87 LRCSGGMRL--TATYRYILSCHCE 108 (122) T ss_dssp EEBSSSCEE--EEEEEEEEEEEEE T ss_pred EECCCCceE--EEEEEEEEeceee Confidence 332333322 2334578999994