Mercurial > repos > iuc > bigscape
view test-data/NC_012963.1.region001.no-genbank-suffix @ 3:3447eb0ce896 draft default tip
planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/bigscape/ commit 8a0f3092ca824856263328efe66941409f527ca4
author | iuc |
---|---|
date | Sun, 11 Aug 2024 21:09:00 +0000 |
parents | |
children |
line wrap: on
line source
LOCUS NC_012963 44203 bp DNA linear CON 17-FEB-2023 DEFINITION Komagataella phaffii GS115 chromosome 1, complete sequence. ACCESSION NC_012963 VERSION NC_012963.1 KEYWORDS . SOURCE Komagataella phaffii GS115 ORGANISM Komagataella phaffii GS115 Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella. COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to FN392319. Contact: Nico Callewaert Unit for Molecular Glycobiology Laboratory for Protein Biochemistry and Biomolecular Engineering Department of Biochemistry, Physiology and Microbiology, UGent VIB Department for Molecular Biomedical Research, UGent Technologiepark 927, B-9052 Gent, Belgium Tel: (32)93313630 Fax: (32)93313609 Email: nico.callewaert@dmbr.vib-UGent.be ----------- sequencing/assembly Unit for Molecular Glycobiology Laboratory for Protein Biochemistry and Biomolecular Engineering Department of Biochemistry, Physiology and Microbiology, UGent VIB Department for Molecular Biomedical Research, UGent ----------- annotation Unit for Molecular Glycobiology Laboratory for Protein Biochemistry and Biomolecular Engineering Department of Biochemistry, Physiology and Microbiology, UGent VIB Department for Molecular Biomedical Research, UGent Laboratory for Bioinformatics and Evolutionary Genomics VIB Department of Plant Systems Biology, UGent Web site: http://bioinformatics.psb.ugent.be/ Bioinformatics Online Genome Annotation System (BOGAS): http://bioinformatics.psb.ugent.be/webtools/bogas/ ----------- * NOTE: finishing of chromosomes in process * Final curation of the annotation in progress. ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2023-11-19 21:18:41 NOTE: This is a single region extracted from a larger record! Orig. start :: 1667272 Orig. end :: 1711475 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..44203 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="False" /core_location="[20000:24203]" /cutoff="0" /detection_rule="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS-like" /protocluster_number="1" /tool="antismash" proto_core 20001..24203 /aStool="rule-based-clusters" /tool="antismash" /cutoff="0" /detection_rule="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS-like" /protocluster_number="1" cand_cluster 1..44203 /SMILES="NC(CCCC(=O)O)C(=O)O" /candidate_cluster_number="1" /contig_edge="False" /detection_rules="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /kind="single" /product="NRPS-like" /protoclusters="1" /tool="antismash" region 1..44203 /candidate_cluster_numbers="1" /contig_edge="False" /product="NRPS-like" /region_number="1" /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /tool="antismash" gene <1724..>3658 /db_xref="GeneID:8197127" /locus_tag="PAS_chr1-4_0143" mRNA <1724..>3658 /db_xref="GeneID:8197127" /locus_tag="PAS_chr1-4_0143" /product="Type II phosphatidylinositol 4-kinase that binds Las17p" /transcript_id="XM_002490207.1" CDS 1724..3658 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0143" /db_xref="EnsemblGenomes-Tr:CAY67971" /db_xref="GeneID:8197127" /db_xref="GOA:C4QXJ8" /db_xref="InterPro:IPR000403" /db_xref="UniProtKB/TrEMBL:C4QXJ8" /locus_tag="PAS_chr1-4_0143" /product="Type II phosphatidylinositol 4-kinase that binds Las17p" /protein_id="XP_002490252.1" /transl_table=1 /translation="MDSKPLSGVSLAEASNLNLDPSVQLRSNSSIQENYPDPANVYTEQ LGHSPSERDTLLPQSPNYNATSPSQGAGRSPLSKKKRTRSLLSTDKLKSLNTKLGKWTR GLSYKWWIVRSKDVEGQPSEILFSVFMAPPYVQPLRRLPAGGLMNMGPTSREDFAHIVD DVIDAIEQGIKPTRISQGSSGSYFMYNTQGKIVGVFKPKDEEPYGPLSPKWTKWIHRNL FPCFFGRSCLIPNLGYIAESAASLLDRQLQSFIVPYTDTVLLSSSSFYYAFWDRCTHAW SKKPYRKKVGSFQLYLNGYIGADEFFKKYPLPADKGRSLLPFLPDKHKKKKTSKKRQRG DTRHSIFDKDTVFEWNRDTLQQLREQLEKLVILDYIIRNTDRAFDNWMIKVEWDEYLDE EANEAYKRPNLKVRAIDSGLAFPWKHPNEWRSFPFGWLYLPTSVIARPFSERTRRHYLP LLTSKEWWEETSVLFREMFSRDTEFKERMWRRQWAVLKGQAFNVVETLKIPGQSPLDLV QKTRIMVWDNVVEIPVSYVPRDIDIYNDSPVWTYQNYDEEYWSSNIAHNSPGRYHEHEP TTPESECLDDPFSSAASTDRGGYAISSNANTPGRANTDSIQKPTTATRRLIVERLETIT SKPPVFTWC" PFAM_domain 2264..3229 /aSDomain="PI3_PI4_kinase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00454.30" /description="Phosphatidylinositol 3- and 4-kinase" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0143_0001" /evalue="9.30E-47" /label="PAS_chr1-4_0143" /locus_tag="PAS_chr1-4_0143" /protein_end="502" /protein_start="180" /score="160.1" /tool="antismash" /translation="GSSGSYFMYNTQGKIVGVFKPKDEEPYGPLSPKWTKWIHRNLFPC FFGRSCLIPNLGYIAESAASLLDRQLQSFIVPYTDTVLLSSSSFYYAFWDRCTHAWSKK PYRKKVGSFQLYLNGYIGADEFFKKYPLPADKGRSLLPFLPDKHKKKKTSKKRQRGDTR HSIFDKDTVFEWNRDTLQQLREQLEKLVILDYIIRNTDRAFDNWMIKVEWDEYLDEEAN EAYKRPNLKVRAIDSGLAFPWKHPNEWRSFPFGWLYLPTSVIARPFSERTRRHYLPLLT SKEWWEETSVLFREMFSRDTEFKERMWRRQWAVLKGQAFNV" gene <3761..>4714 /db_xref="GeneID:8197128" /locus_tag="PAS_chr1-4_0144" mRNA <3761..>4714 /db_xref="GeneID:8197128" /locus_tag="PAS_chr1-4_0144" /product="pyridoxal kinase BUD16" /transcript_id="XM_002490208.1" CDS 3761..4714 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0144" /db_xref="EnsemblGenomes-Tr:CAY67972" /db_xref="GeneID:8197128" /db_xref="GOA:C4QXJ9" /db_xref="InterPro:IPR004625" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="UniProtKB/TrEMBL:C4QXJ9" /locus_tag="PAS_chr1-4_0144" /product="pyridoxal kinase BUD16" /protein_id="XP_002490253.1" /transl_table=1 /translation="MVTPANKIISIQSHVAHGYVGNKVAGFVLQCQYWDVDLLNTVNFS NHTGYGSFKGQATTGEQVLSLYEGLQDINVQYDAMLTGYIQGADGVEAMGKVCLDLKER TPGILWLLDPVMGDEGELYVSADVIPAYRRILGYKKVDIITPNQYEAELLVGFSINNTD DLRKALKVFHEDFNVMHVVISTFSFTKNKDFFYCVSSTKTSYKKPNFFKIPYMDSYFTG VGDLFSALLVDKIYRLPGGEPIEPAVSNALTIMEKVLDVTRRLCVDKLGVAVQGKIGDA ETMKECELRIVECRQFYTMKDRNFNCETKILTDSQA" aSDomain 3776..4603 /aSDomain="TIGR00687" /aSTool="tigrfam" /description="pyridox_kin: pyridoxal kinase" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0144_0001" /evalue="4.20E-52" /identifier="TIGR00687" /label="PAS_chr1-4_0144" /locus_tag="PAS_chr1-4_0144" /protein_end="281" /protein_start="5" /score="175.2" /tool="antismash" /translation="NKIISIQSHVAHGYVGNKVAGFVLQCQYWDVDLLNTVNFSNHTGY GSFKGQATTGEQVLSLYEGLQDINVQYDAMLTGYIQGADGVEAMGKVCLDLKERTPGIL WLLDPVMGDEGELYVSADVIPAYRRILGYKKVDIITPNQYEAELLVGFSINNTDDLRKA LKVFHEDFNVMHVVISTFSFTKNKDFFYCVSSTKTSYKKPNFFKIPYMDSYFTGVGDLF SALLVDKIYRLPGGEPIEPAVSNALTIMEKVLDVTRRLCVDKLGVAVQGKIGDA" PFAM_domain 3983..4537 /aSDomain="Phos_pyr_kin" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF08543.15" /description="Phosphomethylpyrimidine kinase" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0144_0002" /evalue="1.10E-11" /label="PAS_chr1-4_0144" /locus_tag="PAS_chr1-4_0144" /protein_end="259" /protein_start="74" /score="44.7" /tool="antismash" /translation="VQYDAMLTGYIQGADGVEAMGKVCLDLKERTPGILWLLDPVMGDE GELYVSADVIPAYRRILGYKKVDIITPNQYEAELLVGFSINNTDDLRKALKVFHEDFNV MHVVISTFSFTKNKDFFYCVSSTKTSYKKPNFFKIPYMDSYFTGVGDLFSALLVDKIYR LPGGEPIEPAVSNALTIMEKVL" gene <5176..>7806 /db_xref="GeneID:8197129" /locus_tag="PAS_chr1-4_0656" mRNA <5176..>7806 /db_xref="GeneID:8197129" /locus_tag="PAS_chr1-4_0656" /product="uncharacterized protein" /transcript_id="XM_002490209.1" CDS 5176..7806 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0656" /db_xref="EnsemblGenomes-Tr:CAY67973" /db_xref="GeneID:8197129" /db_xref="GOA:C4QXK0" /db_xref="InterPro:IPR001680" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR017149" /db_xref="InterPro:IPR017986" /db_xref="InterPro:IPR019775" /db_xref="UniProtKB/TrEMBL:C4QXK0" /gene_functions="other (smcogs) SMCOG1173:WD-40 repeat-containing protein (Score: 83.6; E-value: 2e-25)" /gene_kind="other" /locus_tag="PAS_chr1-4_0656" /product="uncharacterized protein" /protein_id="XP_002490254.1" /transl_table=1 /translation="MNPLDVIGSDGNNHVSKQLPLKTASSCFNSSFSSLTKQFTPELLK SDNESVESLANYPLLTDNPSLVHQWNHEYSVVCVSVSSSRGLLFCGTQDAKILVFDLNT YEKIHVLQAHEGAVLCLEISANEKFLFSGGSDSLLRIWDLETMTERFTIYSLMDIGDIF SITWIQDLNMVFFGTQNACILYAYVEVDGSWKNDPSFLPANRYDNFFDSKGPGGNMNPK QSKKNKQHTSPLVEVDTYNILRYAHNGYVYAMQSFKRTPETVEIFINIPNIYNHILVSG GGDGLVKLWGVGSDRSVVALHELDNEDSVLSMVISGSFLYAGLVDGQVNLWDLGTFQLI RSTKTDEGDVLSLALYADCLFKGTEHGITKWKLQGARRTDWVTHEGYALTVKLFERQGN PYLITGGVNNRLALWSLDGVYSASKRRSLSLSKKSILPLDNDSLLQTLAKFVSYKTVSK LPQFFIDDSRRCASFLVNLLTSFGATAQLIPVKNGNPIIHACFPAQVINSAKKKPSRIL WYGHYDVVSADQSNGWVQDPFKMSAMDGYLYGRGVTDNKGPLLAAIYSVAELFSQDALK SDVVFLIEGEEESASFGFQEAVGAYKDVVGEIDWIFLSNSYWIDDHLPCINYGLRGVVG VKVEISSDKPDRHSGVDGGVSREPAVDLVKLISKLTSDEGRILLPGFFDGLNPPSEEEE KDYERILERAKIKSSKEMLMAKWRYPSLTVHKVTVSGPGNNTIIPQMASAAISLRITPE QNLESVKNMLVSFLKDKFKDLKTENECKISITHEAEPWLGDRRNTGFQVLENAIINEWG IEPLYIREGGSIPSIRFLEKAFGAPAIHYPCGQASDNAHLDNERLRVRNLYKSRNILNR VFQTL" PFAM_domain 5491..5604 /aSDomain="WD40" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00400.35" /db_xref="GO:0005515" /description="WD domain, G-beta repeat" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0656_0003" /evalue="3.30E-05" /gene_ontologies="GO:0005515: protein binding" /label="PAS_chr1-4_0656" /locus_tag="PAS_chr1-4_0656" /protein_end="143" /protein_start="105" /score="24.7" /tool="antismash" /translation="EKIHVLQAHEGAVLCLEISANEKFLFSGGSDSLLRIWD" PFAM_domain 6727..7794 /aSDomain="Peptidase_M20" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01546.31" /db_xref="GO:0016787" /description="Peptidase family M20/M25/M40" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0656_0004" /evalue="1.30E-23" /gene_ontologies="GO:0016787: hydrolase activity" /label="PAS_chr1-4_0656" /locus_tag="PAS_chr1-4_0656" /protein_end="873" /protein_start="517" /score="83.9" /tool="antismash" /translation="WYGHYDVVSADQSNGWVQDPFKMSAMDGYLYGRGVTDNKGPLLAA IYSVAELFSQDALKSDVVFLIEGEEESASFGFQEAVGAYKDVVGEIDWIFLSNSYWIDD HLPCINYGLRGVVGVKVEISSDKPDRHSGVDGGVSREPAVDLVKLISKLTSDEGRILLP GFFDGLNPPSEEEEKDYERILERAKIKSSKEMLMAKWRYPSLTVHKVTVSGPGNNTIIP QMASAAISLRITPEQNLESVKNMLVSFLKDKFKDLKTENECKISITHEAEPWLGDRRNT GFQVLENAIINEWGIEPLYIREGGSIPSIRFLEKAFGAPAIHYPCGQASDNAHLDNERL RVRNLYKSRNILNRVF" gene complement(<7821..>8807) /db_xref="GeneID:8197865" /locus_tag="PAS_chr1-4_0145" mRNA complement(<7821..>8807) /db_xref="GeneID:8197865" /locus_tag="PAS_chr1-4_0145" /product="pirin" /transcript_id="XM_002490210.1" CDS complement(7821..8807) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0145" /db_xref="EnsemblGenomes-Tr:CAY67974" /db_xref="GeneID:8197865" /db_xref="InterPro:IPR003829" /db_xref="InterPro:IPR008778" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR012093" /db_xref="InterPro:IPR014710" /db_xref="UniProtKB/TrEMBL:C4QXK1" /gene_functions="other (smcogs) SMCOG1208:pirin domain-containing protein (Score: 191.5; E-value: 3.1e-58)" /gene_kind="other" /locus_tag="PAS_chr1-4_0145" /product="pirin" /protein_id="XP_002490255.1" /transl_table=1 /translation="MSRSVLKSFYCNEVSEGVGAKVRRSIGSMQMRNFKPFLLLDHFNV DPSAGFPDHPHRGQETITYMTKGQFAHQDFTSDKVGILNAGDCQIMRAGRGIMHAEMPV QGKSGENIVGMQLWVDLPKHLKHSEPEYRDLRASEIPTVTPNDKVTVKIISGKAYGVEN FQDLSYSPVDYYYYTVQPGGSFEQSVGENYNSFIYLLDGSLEINNKTYDKFNALFFDLN GNKITGSVPEDATSPAEFVLVAGQILDQPIVQHGPFVETSKDLIYKAFMDYQTASNGFE RGKDWRSKIADGVKEDDLAKLKQLFYYYLLHHLYSSYLFTLCIFINY" PFAM_domain complement(7974..8285) /aSDomain="Pirin_C" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF05726.16" /description="Pirin C-terminal cupin domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0145_0006" /evalue="6.10E-18" /label="PAS_chr1-4_0145" /locus_tag="PAS_chr1-4_0145" /protein_end="278" /protein_start="174" /score="65.3" /tool="antismash" /translation="YYYTVQPGGSFEQSVGENYNSFIYLLDGSLEINNKTYDKFNALFF DLNGNKITGSVPEDATSPAEFVLVAGQILDQPIVQHGPFVETSKDLIYKAFMDYQTASN " PFAM_domain complement(8451..8750) /aSDomain="Pirin" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF02678.19" /description="Pirin" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0145_0005" /evalue="1.50E-25" /label="PAS_chr1-4_0145" /locus_tag="PAS_chr1-4_0145" /protein_end="119" /protein_start="19" /score="89.4" /tool="antismash" /translation="AKVRRSIGSMQMRNFKPFLLLDHFNVDPSAGFPDHPHRGQETITY MTKGQFAHQDFTSDKVGILNAGDCQIMRAGRGIMHAEMPVQGKSGENIVGMQLWV" gene complement(<9112..>10335) /db_xref="GeneID:8197130" /locus_tag="PAS_chr1-4_0146" mRNA complement(<9112..>10335) /db_xref="GeneID:8197130" /locus_tag="PAS_chr1-4_0146" /product="Hypothetical protein" /transcript_id="XM_002490211.1" CDS complement(9112..10335) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0146" /db_xref="EnsemblGenomes-Tr:CAY67975" /db_xref="GeneID:8197130" /db_xref="GOA:C4QXK2" /db_xref="InterPro:IPR019038" /db_xref="UniProtKB/TrEMBL:C4QXK2" /locus_tag="PAS_chr1-4_0146" /product="Hypothetical protein" /protein_id="XP_002490256.1" /transl_table=1 /translation="MTQIASYLATKLYEEKLPVTYRMLSRELSIDVRRSKEELAEFYKK DEKLEIIYAVSGIKNGLDIKLVGKQDLETVKQGYEKVLSVACYSLSTSGVGAQEVANME GMRRNEWLNAELQRKLGIIESPFHKEQPAEQIEHVEEQWPKVDVVKQPAPKHSPDPKSQ SPKPPKKTETIPSITSKYVSRKPQNSKSSASVQKTIPTSKAKPNSKSKISYVSRKEPKE SIVAGDIEDDNSFPLNEPPRKKTTEEINKERQELAAMFTDSDDEMQDTQVIQEESAPPK NEDSLFVIDDDEDEGGDQAHAREDANPVDQMDVDLASDFDTSIQEVNPPVASNEPSQNE VEQSKEAITSYVDEDGFITTVKNTKISTDKSSNPKSSSSKPSPTVGTVKGKSSKKAQST LLSFFGKK" PFAM_domain complement(9115..10281) /aSDomain="CDC27" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF09507.13" /db_xref="GO:0005634" /db_xref="GO:0006260" /db_xref="GO:0043625" /description="DNA polymerase subunit Cdc27" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0146_0007" /evalue="3.70E-11" /gene_ontologies="GO:0005634: nucleus" /gene_ontologies="GO:0006260: DNA replication" /gene_ontologies="GO:0043625: delta DNA polymerase complex" /label="PAS_chr1-4_0146" /locus_tag="PAS_chr1-4_0146" /protein_end="407" /protein_start="18" /score="43.2" /tool="antismash" /translation="VTYRMLSRELSIDVRRSKEELAEFYKKDEKLEIIYAVSGIKNGLD IKLVGKQDLETVKQGYEKVLSVACYSLSTSGVGAQEVANMEGMRRNEWLNAELQRKLGI IESPFHKEQPAEQIEHVEEQWPKVDVVKQPAPKHSPDPKSQSPKPPKKTETIPSITSKY VSRKPQNSKSSASVQKTIPTSKAKPNSKSKISYVSRKEPKESIVAGDIEDDNSFPLNEP PRKKTTEEINKERQELAAMFTDSDDEMQDTQVIQEESAPPKNEDSLFVIDDDEDEGGDQ AHAREDANPVDQMDVDLASDFDTSIQEVNPPVASNEPSQNEVEQSKEAITSYVDEDGFI TTVKNTKISTDKSSNPKSSSSKPSPTVGTVKGKSSKKAQSTLLSFFGKK" gene <10871..>12145 /db_xref="GeneID:8197131" /locus_tag="PAS_chr1-4_0147" mRNA <10871..>12145 /db_xref="GeneID:8197131" /locus_tag="PAS_chr1-4_0147" /product="eukaryotic translation initiation factor 3 subunit" /transcript_id="XM_002490212.1" CDS 10871..12145 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0147" /db_xref="EnsemblGenomes-Tr:CAY67976" /db_xref="GeneID:8197131" /db_xref="GOA:C4QXK3" /db_xref="InterPro:IPR000717" /db_xref="InterPro:IPR016650" /db_xref="InterPro:IPR019010" /db_xref="UniProtKB/TrEMBL:C4QXK3" /locus_tag="PAS_chr1-4_0147" /product="eukaryotic translation initiation factor 3 subunit" /protein_id="XP_002490257.1" /transl_table=1 /translation="MAQLTPAEIEVAKKFDLTSKIIPFLDRHLIYPLIENLDLTYDEKT IKELSYNLLRDTYMNKFINDLNPDKEISQDVLTKQKEIEAKSEVLEAETKETLNLLSKK EVQEQLKSDKNHNRRYLESQHGITEDKIHALYEYGQIQYNKGDYVMASDLLANFRILST NNELNVSSTWGRLACEILLLEWNNALEELSKLRELIDSRTSFNDPLLQLYNRTWVIHWS LFPYFKTANGLETLCDLFFSSSYLSTIQASCPWVLRYLVVAVISNNSKKLKDLVRVTAQ ESYQYADPFTNLIKALYLDFDFAQASQHLNDCEVILKTDFFLNNEDENLPLISKKFITN AKKLIIQVYVKCYGRISLEALSETLNLTKQELKDLIASLDLKNATLDDEKLIINHTSTK IYQQVSDKVKSLGYKSNQLLENFAK" PFAM_domain 10916..11296 /aSDomain="eIF3_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF09440.13" /description="eIF3 subunit 6 N terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0147_0008" /evalue="3.50E-32" /label="PAS_chr1-4_0147" /locus_tag="PAS_chr1-4_0147" /protein_end="142" /protein_start="15" /score="111.7" /tool="antismash" /translation="DLTSKIIPFLDRHLIYPLIENLDLTYDEKTIKELSYNLLRDTYMN KFINDLNPDKEISQDVLTKQKEIEAKSEVLEAETKETLNLLSKKEVQEQLKSDKNHNRR YLESQHGITEDKIHALYEYGQIQ" PFAM_domain 11735..12007 /aSDomain="PCI" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01399.30" /description="PCI domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0147_0009" /evalue="4.00E-05" /label="PAS_chr1-4_0147" /locus_tag="PAS_chr1-4_0147" /protein_end="379" /protein_start="288" /score="24.2" /tool="antismash" /translation="PFTNLIKALYLDFDFAQASQHLNDCEVILKTDFFLNNEDENLPLI SKKFITNAKKLIIQVYVKCYGRISLEALSETLNLTKQELKDLIASL" gene complement(<12213..>12851) /db_xref="GeneID:8197132" /locus_tag="PAS_chr1-4_0148" mRNA complement(<12213..>12851) /db_xref="GeneID:8197132" /locus_tag="PAS_chr1-4_0148" /product="Mitochondrial ribosomal protein of the large subunit" /transcript_id="XM_002490213.1" CDS complement(12213..12851) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0148" /db_xref="EnsemblGenomes-Tr:CAY67977" /db_xref="GeneID:8197132" /db_xref="GOA:C4QXK4" /db_xref="InterPro:IPR000456" /db_xref="UniProtKB/TrEMBL:C4QXK4" /locus_tag="PAS_chr1-4_0148" /product="Mitochondrial ribosomal protein of the large subunit" /protein_id="XP_002490258.1" /transl_table=1 /translation="MGLGRSVKHEWAMLRNLASSLIKNESIITTKARAKKTQALVENLI TKAKKNYDKSLILADIFEPNVTIPKLYNVLKPRYQSRAGGYTRILNLEPRMNDKAPQVI MELVDNTQREMKLWYTAKIVARLELQNIAINPLTQKNVDKLLHNRENGEEKFREIVEIC KKEFYSDPKSLENLPRMRNDINTFKKRDHPYKIVPRPVKRNNATVSTSS" aSDomain complement(12525..12845) /aSDomain="TIGR00059" /aSTool="tigrfam" /description="L17: ribosomal protein bL17" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0148_0002" /evalue="4.30E-28" /identifier="TIGR00059" /label="PAS_chr1-4_0148" /locus_tag="PAS_chr1-4_0148" /protein_end="109" /protein_start="2" /score="95.9" /tool="antismash" /translation="LGRSVKHEWAMLRNLASSLIKNESIITTKARAKKTQALVENLITK AKKNYDKSLILADIFEPNVTIPKLYNVLKPRYQSRAGGYTRILNLEPRMNDKAPQVIME LVD" PFAM_domain complement(12528..12815) /aSDomain="Ribosomal_L17" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01196.22" /db_xref="GO:0003735" /db_xref="GO:0005840" /db_xref="GO:0006412" /description="Ribosomal protein L17" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0148_0010" /evalue="1.00E-28" /gene_ontologies="GO:0003735: structural constituent of ribosome" /gene_ontologies="GO:0005840: ribosome" /gene_ontologies="GO:0006412: translation" /label="PAS_chr1-4_0148" /locus_tag="PAS_chr1-4_0148" /protein_end="108" /protein_start="12" /score="100.2" /tool="antismash" /translation="MLRNLASSLIKNESIITTKARAKKTQALVENLITKAKKNYDKSLI LADIFEPNVTIPKLYNVLKPRYQSRAGGYTRILNLEPRMNDKAPQVIMELV" gene <13073..>13381 /db_xref="GeneID:8197133" /locus_tag="PAS_chr1-4_0694" mRNA <13073..>13381 /db_xref="GeneID:8197133" /locus_tag="PAS_chr1-4_0694" /product="uncharacterized protein" /transcript_id="XM_002490214.1" CDS 13073..13381 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0694" /db_xref="EnsemblGenomes-Tr:CAY67978" /db_xref="GeneID:8197133" /db_xref="UniProtKB/TrEMBL:C4QXK5" /locus_tag="PAS_chr1-4_0694" /product="uncharacterized protein" /protein_id="XP_002490259.1" /transl_table=1 /translation="MGGRIYGFLAGALFTSSLTYLAREQFQSDQVRISTRLRSYQKLIN EGDQLKLTDNKLEYQTRPWKEAFKDLWNEEVIKTVNRIYSIRWYEDAKYLVDKVEGK" PFAM_domain 13163..13336 /aSDomain="AIM5" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF17050.8" /db_xref="GO:0042407" /db_xref="GO:0044284" /db_xref="GO:0061617" /description="Altered inheritance of mitochondria 5" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0694_0011" /evalue="3.20E-10" /gene_ontologies="GO:0042407: cristae formation" /gene_ontologies="GO:0044284: mitochondrial crista junction" /gene_ontologies="GO:0061617: MICOS complex" /label="PAS_chr1-4_0694" /locus_tag="PAS_chr1-4_0694" /protein_end="88" /protein_start="30" /score="40.7" /tool="antismash" /translation="VRISTRLRSYQKLINEGDQLKLTDNKLEYQTRPWKEAFKDLWNEE VIKTVNRIYSIRW" gene complement(<13401..>14441) /db_xref="GeneID:8197438" /locus_tag="PAS_chr1-4_0149" mRNA complement(<13401..>14441) /db_xref="GeneID:8197438" /locus_tag="PAS_chr1-4_0149" /product="3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis" /transcript_id="XM_002490215.1" CDS complement(13401..14441) /NRPS_PKS="Domain: PKS_KR (42-206). E-value: 1.9e-08. Score: 26.3. Matches aSDomain: nrpspksdomains_PAS_chr1-4_0149_PKS_KR.1" /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0149" /db_xref="EnsemblGenomes-Tr:CAY67979" /db_xref="GeneID:8197438" /db_xref="GOA:C4QXK6" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR016040" /db_xref="UniProtKB/TrEMBL:C4QXK6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001:short-chain dehydrogenase/reductase SDR (Score: 105.5; E-value: 5.4e-32)" /gene_kind="biosynthetic-additional" /locus_tag="PAS_chr1-4_0149" /product="3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis" /protein_id="XP_002490260.1" /transl_table=1 /translation="MILVHDTTLSSNIWCTISAIILIQSVEGTGMFDNFDVTNKKAIIT GASQGVGAEFAKLLYGKGCSVVIVARTESLLKQVVKDAIDIHGTEKGNTISYVAADISK YDQCERVLEEVGFSPDIVFCCAGSSIPGLFLELDEKTLSSGIDINYKTALYFSHVALKV MTKVEKPYKRHLVFFSSVLAFYSFIGYGQYAPMKAALRSLSDILRQEVSIHNIKVECIF PGNTLSEGFLEEEKSKPEITRIIEGPSSPISTEQCCKIIYNALQSGYQYVTTDFIGYVL MSASLGGSPRYYGVIQVIISFLFSIFAPIASMFVNKQIRDYFKKQSRISPSSSSSPSPE REQKDK" PFAM_domain complement(13752..14324) /aSDomain="adh_short" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00106.28" /description="short chain dehydrogenase" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0149_0012" /evalue="4.30E-30" /label="PAS_chr1-4_0149" /locus_tag="PAS_chr1-4_0149" /protein_end="230" /protein_start="39" /score="104.8" /tool="antismash" /translation="KKAIITGASQGVGAEFAKLLYGKGCSVVIVARTESLLKQVVKDAI DIHGTEKGNTISYVAADISKYDQCERVLEEVGFSPDIVFCCAGSSIPGLFLELDEKTLS SGIDINYKTALYFSHVALKVMTKVEKPYKRHLVFFSSVLAFYSFIGYGQYAPMKAALRS LSDILRQEVSIHNIKVECIFPGNTLSEG" aSDomain complement(13824..14315) /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PAS_chr1-4_0149_PKS_KR.1" /evalue="1.90E-08" /label="PAS_chr1-4_0149_PKS_KR.1" /locus_tag="PAS_chr1-4_0149" /protein_end="206" /protein_start="42" /score="26.3" /specificity="KR activity: inactive" /specificity="KR stereochemistry: C2" /tool="antismash" /translation="IITGASQGVGAEFAKLLYGKGCSVVIVARTESLLKQVVKDAIDIH GTEKGNTISYVAADISKYDQCERVLEEVGFSPDIVFCCAGSSIPGLFLELDEKTLSSGI DINYKTALYFSHVALKVMTKVEKPYKRHLVFFSSVLAFYSFIGYGQYAPMKAALRSLSD I" gene <15004..>17043 /db_xref="GeneID:8197134" /locus_tag="PAS_chr1-4_0150" mRNA <15004..>17043 /db_xref="GeneID:8197134" /locus_tag="PAS_chr1-4_0150" /product="Transketolase, similar to Tkl2p" /transcript_id="XM_002490216.1" CDS 15004..17043 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0150" /db_xref="EnsemblGenomes-Tr:CAY67980" /db_xref="GeneID:8197134" /db_xref="GOA:C4QXK7" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005476" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="UniProtKB/TrEMBL:C4QXK7" /gene_functions="biosynthetic-additional (smcogs) SMCOG1204:transketolase (Score: 643.7; E-value: 6.2e-195)" /gene_kind="biosynthetic-additional" /locus_tag="PAS_chr1-4_0150" /product="Transketolase, similar to Tkl2p" /protein_id="XP_002490261.1" /transl_table=1 /translation="MSDLLAINTIRLLAVDTVAKANSGHPGAPMGLAPAAHTLFKQMRF NPRNPAWINRDRFVLSNGHACALLYTMLFLYGYDYTIDDLKSFRQLNSKTPGHPEAELP GVEVTTGPLGQGIANAVGLAIAQAQLAATYNKPNYELFSNYTYAFLGDGCLQEGVAQEA ISLAGHLGDGLKLIAFWDDNQISIDGDTNVSFTEDVPAKFRAQGWEVLSVKDGNDDLEG IAAALAKAKTTNKPTLIRLPTIIGYGSLQQGTHGVHGSPLKPDDIKQLKKKFGFDPEQN FVVPREVTESYAKHVADNQQVEVEWNKLLTAYTKEYPELGQELHRRLDGKLPENWQKAL PTYTVDDKPVASRKLSEIVLTSIEKELPELVGGSADLTGSNLTRWPDAVDFQPKSTGLG DFSGRYFRFGVREHGMGAIINGISAYGANFKAYGGTFLNFVSYASGAVRLSALSGHPII WVATHDSIGLGEDGPTHQPIETLAHLRALPNLMVWRPADGNETSAAYLRAIESKHTPSI IALTRQNLPQLEHSSIEKAAKGGYTVYPVENPDIILVASGSEVSIAIDGAKKLGTEGVK ASVVSIPDFFTFDSQARSYQLSVLPDGVPIMSVEVMSTFGWSKYSHEQFGINRFGISGP GPEIYKFFEFTAEGVADRASKVVQFYKGKELLSPLNKAFESVHA" PFAM_domain 15016..16002 /aSDomain="Transketolase_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00456.24" /description="Transketolase, thiamine diphosphate binding domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0150_0013" /evalue="6.30E-150" /label="PAS_chr1-4_0150" /locus_tag="PAS_chr1-4_0150" /protein_end="333" /protein_start="4" /score="498.9" /tool="antismash" /translation="LAINTIRLLAVDTVAKANSGHPGAPMGLAPAAHTLFKQMRFNPRN PAWINRDRFVLSNGHACALLYTMLFLYGYDYTIDDLKSFRQLNSKTPGHPEAELPGVEV TTGPLGQGIANAVGLAIAQAQLAATYNKPNYELFSNYTYAFLGDGCLQEGVAQEAISLA GHLGDGLKLIAFWDDNQISIDGDTNVSFTEDVPAKFRAQGWEVLSVKDGNDDLEGIAAA LAKAKTTNKPTLIRLPTIIGYGSLQQGTHGVHGSPLKPDDIKQLKKKFGFDPEQNFVVP REVTESYAKHVADNQQVEVEWNKLLTAYTKEYPELGQELHRRLDGKLP" aSDomain 15019..16977 /aSDomain="TIGR00232" /aSTool="tigrfam" /description="tktlase_bact: transketolase" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0150_0003" /evalue="3.90E-277" /identifier="TIGR00232" /label="PAS_chr1-4_0150" /locus_tag="PAS_chr1-4_0150" /protein_end="658" /protein_start="5" /score="918.9" /tool="antismash" /translation="AINTIRLLAVDTVAKANSGHPGAPMGLAPAAHTLFKQMRFNPRNP AWINRDRFVLSNGHACALLYTMLFLYGYDYTIDDLKSFRQLNSKTPGHPEAELPGVEVT TGPLGQGIANAVGLAIAQAQLAATYNKPNYELFSNYTYAFLGDGCLQEGVAQEAISLAG HLGDGLKLIAFWDDNQISIDGDTNVSFTEDVPAKFRAQGWEVLSVKDGNDDLEGIAAAL AKAKTTNKPTLIRLPTIIGYGSLQQGTHGVHGSPLKPDDIKQLKKKFGFDPEQNFVVPR EVTESYAKHVADNQQVEVEWNKLLTAYTKEYPELGQELHRRLDGKLPENWQKALPTYTV DDKPVASRKLSEIVLTSIEKELPELVGGSADLTGSNLTRWPDAVDFQPKSTGLGDFSGR YFRFGVREHGMGAIINGISAYGANFKAYGGTFLNFVSYASGAVRLSALSGHPIIWVATH DSIGLGEDGPTHQPIETLAHLRALPNLMVWRPADGNETSAAYLRAIESKHTPSIIALTR QNLPQLEHSSIEKAAKGGYTVYPVENPDIILVASGSEVSIAIDGAKKLGTEGVKASVVS IPDFFTFDSQARSYQLSVLPDGVPIMSVEVMSTFGWSKYSHEQFGINRFGISGPGPEIY KFFEFTAEGVADRASKVV" PFAM_domain 16048..16581 /aSDomain="Transket_pyr" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF02779.27" /description="Transketolase, pyrimidine binding domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0150_0014" /evalue="7.70E-45" /label="PAS_chr1-4_0150" /locus_tag="PAS_chr1-4_0150" /protein_end="526" /protein_start="348" /score="152.9" /tool="antismash" /translation="PVASRKLSEIVLTSIEKELPELVGGSADLTGSNLTRWPDAVDFQP KSTGLGDFSGRYFRFGVREHGMGAIINGISAYGANFKAYGGTFLNFVSYASGAVRLSAL SGHPIIWVATHDSIGLGEDGPTHQPIETLAHLRALPNLMVWRPADGNETSAAYLRAIES KHTPSIIALTRQNLP" PFAM_domain 16621..16953 /aSDomain="Transketolase_C" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF02780.23" /description="Transketolase, C-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0150_0015" /evalue="4.90E-09" /label="PAS_chr1-4_0150" /locus_tag="PAS_chr1-4_0150" /protein_end="650" /protein_start="539" /score="36.2" /tool="antismash" /translation="GYTVYPVENPDIILVASGSEVSIAIDGAKKLGTEGVKASVVSIPD FFTFDSQARSYQLSVLPDGVPIMSVEVMSTFGWSKYSHEQFGINRFGISGPGPEIYKFF EFTAEGV" gene <17228..>17698 /db_xref="GeneID:8197135" /locus_tag="PAS_chr1-4_0151" mRNA <17228..>17698 /db_xref="GeneID:8197135" /locus_tag="PAS_chr1-4_0151" /product="Protein phosphotyrosine phosphatase" /transcript_id="XM_002490217.1" CDS 17228..17698 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0151" /db_xref="EnsemblGenomes-Tr:CAY67981" /db_xref="GeneID:8197135" /db_xref="GOA:C4QXK8" /db_xref="InterPro:IPR000106" /db_xref="InterPro:IPR002115" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="UniProtKB/TrEMBL:C4QXK8" /locus_tag="PAS_chr1-4_0151" /product="Protein phosphotyrosine phosphatase" /protein_id="XP_002490262.1" /transl_table=1 /translation="MAPISVAFVCLGNICRSPMAEAVFTHLVKEKGLDSKFKKIDSFGT SGYHIDDTPDHRSVACCKKHGVPVNHRGQQISPDDFYHFDYILAMDESNLSNLKRIQPK DSNAVVRLFGDYRTDKSFHRIVEDPYYGGSSGFERNFKQITHFSEEFLNKEL" PFAM_domain 17243..17683 /aSDomain="LMWPc" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01451.24" /description="Low molecular weight phosphotyrosine protein phosphatase" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0151_0016" /evalue="5.20E-46" /label="PAS_chr1-4_0151" /locus_tag="PAS_chr1-4_0151" /protein_end="152" /protein_start="5" /score="156.7" /tool="antismash" /translation="VAFVCLGNICRSPMAEAVFTHLVKEKGLDSKFKKIDSFGTSGYHI DDTPDHRSVACCKKHGVPVNHRGQQISPDDFYHFDYILAMDESNLSNLKRIQPKDSNAV VRLFGDYRTDKSFHRIVEDPYYGGSSGFERNFKQITHFSEEFL" gene complement(<17718..>19684) /db_xref="GeneID:8197136" /locus_tag="PAS_chr1-4_0152" mRNA complement(join(<17718..19557,19662..>19684)) /db_xref="GeneID:8197136" /locus_tag="PAS_chr1-4_0152" /product="Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcrip" /transcript_id="XM_002490218.1" CDS complement(join(17718..19557,19662..19684)) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0152" /db_xref="EnsemblGenomes-Tr:CAY67982" /db_xref="GeneID:8197136" /db_xref="GOA:C4QXK9" /db_xref="InterPro:IPR007207" /db_xref="InterPro:IPR007282" /db_xref="InterPro:IPR012270" /db_xref="UniProtKB/TrEMBL:C4QXK9" /locus_tag="PAS_chr1-4_0152" /product="Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcrip" /protein_id="XP_002490263.1" /transl_table=1 /translation="MSQRKLQQEIDRVFKKVKEGLEEFDYVYDKLQACESSSQKEKLES DLKREIKKLQRSRDQIKIWLAGNEVKEKKGLMEHRKLIEHEMERFKEVEKEMKTKAFSK EGLNMNKVDPREKEKSETSKFVESMIEELERQSEALEAQIDQIQSSGKRGKKLDNSKTD QIAELQSSLDRNNWHQEKLQTILRLLQNGNLEADQIQRIQEDIEYYVESNQDADFAEDD GIYDELGLDEIEDGFLFAAASGPLSKDEEGKDENDENVSDNESPSASASSNFAAVNQGS TSDSTVKTAPAAINSSTGSVSNVTSTNSNASVLLNKLTRTSPARSAAATPPHSHNELTG IQSNLKPAVAPVLTPKLKYSKVASTAATASVPPGSTKVGSSTHSTTPTATTAATAHPAV SSSSLPLDSLSSTTTHPNGLDAPTSESSLKIANNLIANLDGVKKECLNKPIKKTPEEMD NMYQLLNSSLLNCPDSFDADVPNMYIPRQPHPTHISFPQEPLLEIMNSAKILQNFDLET LFYCFYYHSYENAADEHKVFDNSGSFLQINTAKELHRRGWKYHKELKTWFLLNNDEANQ TPPPIEEHVQQKSNWKYFDYQETWLPRRKDDFTFEKDKLETLYL" PFAM_domain complement(17736..18185) /aSDomain="NOT2_3_5" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04153.21" /db_xref="GO:0006355" /description="NOT2 / NOT3 / NOT5 family" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0152_0018" /evalue="5.60E-44" /gene_ontologies="GO:0006355: regulation of DNA-templated transcription" /label="PAS_chr1-4_0152" /locus_tag="PAS_chr1-4_0152" /protein_end="615" /protein_start="465" /score="149.5" /tool="antismash" /translation="SSLLNCPDSFDADVPNMYIPRQPHPTHISFPQEPLLEIMNSAKIL QNFDLETLFYCFYYHSYENAADEHKVFDNSGSFLQINTAKELHRRGWKYHKELKTWFLL NNDEANQTPPPIEEHVQQKSNWKYFDYQETWLPRRKDDFTFEKDKL" PFAM_domain complement(join(18888..19557,19662..19681)) /aSDomain="Not3" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04065.18" /db_xref="GO:0005634" /db_xref="GO:0006355" /description="Not1 N-terminal domain, CCR4-Not complex component" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0152_0017" /evalue="1.30E-89" /gene_ontologies="GO:0005634: nucleus" /gene_ontologies="GO:0006355: regulation of DNA-templated transcription" /label="PAS_chr1-4_0152" /locus_tag="PAS_chr1-4_0152" /protein_end="231" /protein_start="1" /score="299.7" /tool="antismash" /translation="SQRKLQQEIDRVFKKVKEGLEEFDYVYDKLQACESSSQKEKLESD LKREIKKLQRSRDQIKIWLAGNEVKEKKGLMEHRKLIEHEMERFKEVEKEMKTKAFSKE GLNMNKVDPREKEKSETSKFVESMIEELERQSEALEAQIDQIQSSGKRGKKLDNSKTDQ IAELQSSLDRNNWHQEKLQTILRLLQNGNLEADQIQRIQEDIEYYVESNQDADFAEDDG IYDELGLD" gene <20001..>24203 /db_xref="GeneID:8197137" /locus_tag="PAS_chr1-4_0153" mRNA <20001..>24203 /db_xref="GeneID:8197137" /locus_tag="PAS_chr1-4_0153" /product="Alpha aminoadipate reductase" /transcript_id="XM_002490219.1" CDS 20001..24203 /NRPS_PKS="Domain: AMP-binding (250-716). E-value: 1.3e-72. Score: 236.5. Matches aSDomain: nrpspksdomains_PAS_chr1-4_0153_AMP-binding.1" /NRPS_PKS="Domain: PCP (859-928). E-value: 1.4e-17. Score: 55.6. Matches aSDomain: nrpspksdomains_PAS_chr1-4_0153_PCP.1" /NRPS_PKS="Domain: NAD_binding_4 (987-1234). E-value: 4.7e-77. Score: 250.3. Matches aSDomain: nrpspksdomains_PAS_chr1-4_0153_NAD_binding_4.1" /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0153" /db_xref="EnsemblGenomes-Tr:CAY67983" /db_xref="GeneID:8197137" /db_xref="GOA:C4QXL0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010080" /db_xref="InterPro:IPR013120" /db_xref="InterPro:IPR014397" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="UniProtKB/TrEMBL:C4QXL0" /gene_functions="biosynthetic (rule-based-clusters) NRPS-like: PP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS-like: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS-like: NAD_binding_4" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002:AMP-dependent synthetase and ligase (Score: 239; E-value: 1.3e-72)" /gene_kind="biosynthetic" /locus_tag="PAS_chr1-4_0153" /product="Alpha aminoadipate reductase" /protein_id="XP_002490264.1" /sec_met_domain="AMP-binding (E-value: 5.8e-98, bitscore: 324.7, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 1.5e-15, bitscore: 54.0, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="NAD_binding_4 (E-value: 1.3e-75, bitscore: 250.3, seeds: 102, tool: rule-based-clusters)" /transl_table=1 /translation="MSEENLNYWANILDGPTLSVLPRDYNRPVAGKVIEANKTFDISDI LPFLNKANEPSVTQFTAPLAVFAVLVYRLTGDDDIVILTDSPKKQNLPFVVRLQVDPSK SFVDVSKQVGEQYLESLERATPLKDIVTHLKESKQLPNYPPIFRLSFQTAKKVQQLSTL VEGSTRDLAIFLENNTSINIYYNSLLYTHNRIAYFSQQFSSFIDEVNKAPETPIGKISL LTEQQSKLLPDPTANLDWSGYRGAIQDIFSDNAEKFPDRTCVVETKSFLNPNSQTRTFT YKQIDQASNIVGNYLVHTGIKRGDVVMIYAYRGVDLMVAVMGVLKAGATFSVIDPAYPP ARQNVYLQVAKPAGLIVLEKAGVLDQLVEDYIKNELSLVSRISNLKIEADGNVLGGDVD GKDALYDYQQFKTRRTGVLVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFPWMSKTF NLSENDKFTMLSGIAHDPIQRDMFTPLFLGAQLLIPTSDDIGTPGKLAEWMQTYGATVT HLTPAMGQLLSAQATKEIPSLHHAFFVGDILTKRDCLRLQTIAQNVNIINMYGTTETQR AVSYFEIPSRAQDSTFLEVQKDIMPAGKGMHNVQLLVVNRHDRSKTCAIGEVGEIYVRA AGLAEQYRGQPDLNKEKFVPNWFVSPSKWVEEDKKISKDEPWREFYLGPRDRLYRTGDL GRYLPTGDCEVSGRADDQVKIRGFRIELGEIDTHISRHPLIRQNVTLVRRDKDEEPILI SYVVPKETPELENFKSSSDDLDDLNDPIVKSLLLYRELIKDLKAHLKKTLASYAIPTII VPMAKLPLNPNGKVDKPKLPFPDTVQLAAVAQKSSAEVDDSEFTTTELQIKDLWLQVLP NPPASISLEDSFFDLGGHSILATRMIFELRRKLAVDLPLGTIFKHPTVKLFAAEVDRVK NGDEVQFADNKQESTSAGSDEQVVDYFQDAKDLVSSQLLDSYKSRLALSNAELINIFLT GATGFLGSYILKDLLERDLDVQVYAHVRAKDEESGLERLRNTGKVYGIWNEEWTSRIKV VIADLSKDKLGLSGEKYAELANTIDLIIHNGALVHWVYPYSKLRDANVISTINVLNLAA SGKPKQFGFVSSTSTLDTEHYITLSDTLTEQGEDGIPESDDLLGSSKGLGTGYGQSKWA AEYIIRRAFERGLRGAIIRPGYVTGHSRTGACNTDDFLLRMLKGCAELGKLPNISNTVN MVPVDHVALVVTASSLHPTAEEGHCVVQVTGHPRIRFNEFLNALNDYGYEVKLTDYVEW KRDLERFVVDQSKDSALYPLLHFVLDNLPQDTKAPELDDKNAKDILSGDTRWTGYDGSK GRGVDSAQTGIYIAYLIKTGFLPPPSKEGKKPLPEIEISEESLKLIKEGAGARTSAA" PFAM_domain 20007..20690 /aSDomain="Condensation" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00668.23" /db_xref="GO:0003824" /description="Condensation domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0153_0019" /evalue="3.30E-13" /gene_ontologies="GO:0003824: catalytic activity" /label="PAS_chr1-4_0153" /locus_tag="PAS_chr1-4_0153" /protein_end="230" /protein_start="2" /score="49.2" /tool="antismash" /translation="EENLNYWANILDGPTLSVLPRDYNRPVAGKVIEANKTFDISDILP FLNKANEPSVTQFTAPLAVFAVLVYRLTGDDDIVILTDSPKKQNLPFVVRLQVDPSKSF VDVSKQVGEQYLESLERATPLKDIVTHLKESKQLPNYPPIFRLSFQTAKKVQQLSTLVE GSTRDLAIFLENNTSINIYYNSLLYTHNRIAYFSQQFSSFIDEVNKAPETPIGKISLLT EQQSKL" aSDomain 20025..24200 /aSDomain="TIGR03443" /aSTool="tigrfam" /description="alpha_am_amid: L-aminoadipate-semialdehyde dehydrogenase" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0153_0004" /evalue="0.00E+00" /identifier="TIGR03443" /label="PAS_chr1-4_0153" /locus_tag="PAS_chr1-4_0153" /protein_end="1400" /protein_start="8" /score="2297.0" /tool="antismash" /translation="WANILDGPTLSVLPRDYNRPVAGKVIEANKTFDISDILPFLNKAN EPSVTQFTAPLAVFAVLVYRLTGDDDIVILTDSPKKQNLPFVVRLQVDPSKSFVDVSKQ VGEQYLESLERATPLKDIVTHLKESKQLPNYPPIFRLSFQTAKKVQQLSTLVEGSTRDL AIFLENNTSINIYYNSLLYTHNRIAYFSQQFSSFIDEVNKAPETPIGKISLLTEQQSKL LPDPTANLDWSGYRGAIQDIFSDNAEKFPDRTCVVETKSFLNPNSQTRTFTYKQIDQAS NIVGNYLVHTGIKRGDVVMIYAYRGVDLMVAVMGVLKAGATFSVIDPAYPPARQNVYLQ VAKPAGLIVLEKAGVLDQLVEDYIKNELSLVSRISNLKIEADGNVLGGDVDGKDALYDY QQFKTRRTGVLVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFPWMSKTFNLSENDKF TMLSGIAHDPIQRDMFTPLFLGAQLLIPTSDDIGTPGKLAEWMQTYGATVTHLTPAMGQ LLSAQATKEIPSLHHAFFVGDILTKRDCLRLQTIAQNVNIINMYGTTETQRAVSYFEIP SRAQDSTFLEVQKDIMPAGKGMHNVQLLVVNRHDRSKTCAIGEVGEIYVRAAGLAEQYR GQPDLNKEKFVPNWFVSPSKWVEEDKKISKDEPWREFYLGPRDRLYRTGDLGRYLPTGD CEVSGRADDQVKIRGFRIELGEIDTHISRHPLIRQNVTLVRRDKDEEPILISYVVPKET PELENFKSSSDDLDDLNDPIVKSLLLYRELIKDLKAHLKKTLASYAIPTIIVPMAKLPL NPNGKVDKPKLPFPDTVQLAAVAQKSSAEVDDSEFTTTELQIKDLWLQVLPNPPASISL EDSFFDLGGHSILATRMIFELRRKLAVDLPLGTIFKHPTVKLFAAEVDRVKNGDEVQFA DNKQESTSAGSDEQVVDYFQDAKDLVSSQLLDSYKSRLALSNAELINIFLTGATGFLGS YILKDLLERDLDVQVYAHVRAKDEESGLERLRNTGKVYGIWNEEWTSRIKVVIADLSKD KLGLSGEKYAELANTIDLIIHNGALVHWVYPYSKLRDANVISTINVLNLAASGKPKQFG FVSSTSTLDTEHYITLSDTLTEQGEDGIPESDDLLGSSKGLGTGYGQSKWAAEYIIRRA FERGLRGAIIRPGYVTGHSRTGACNTDDFLLRMLKGCAELGKLPNISNTVNMVPVDHVA LVVTASSLHPTAEEGHCVVQVTGHPRIRFNEFLNALNDYGYEVKLTDYVEWKRDLERFV VDQSKDSALYPLLHFVLDNLPQDTKAPELDDKNAKDILSGDTRWTGYDGSKGRGVDSAQ TGIYIAYLIKTGFLPPPSKEGKKPLPEIEISEESLKLIKEGAGARTSAA" aSDomain 20751..22148 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PAS_chr1-4_0153_AMP-binding.1" /evalue="1.30E-72" /label="PAS_chr1-4_0153_AMP-binding.1" /locus_tag="PAS_chr1-4_0153" /protein_end="716" /protein_start="250" /score="236.5" /specificity="substrate consensus: Aad" /tool="antismash" /translation="FSDNAEKFPDRTCVVETKSFLNPNSQTRTFTYKQIDQASNIVGNY LVHTGIKRGDVVMIYAYRGVDLMVAVMGVLKAGATFSVIDPAYPPARQNVYLQVAKPAG LIVLEKAGVLDQLVEDYIKNELSLVSRISNLKIEADGNVLGGDVDGKDALYDYQQFKTR RTGVLVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFPWMSKTFNLSENDKFTMLSGI AHDPIQRDMFTPLFLGAQLLIPTSDDIGTPGKLAEWMQTYGATVTHLTPAMGQLLSAQA TKEIPSLHHAFFVGDILTKRDCLRLQTIAQNVNIINMYGTTETQRAVSYFEIPSRAQDS TFLEVQKDIMPAGKGMHNVQLLVVNRHDRSKTCAIGEVGEIYVRAAGLAEQYRGQPDLN KEKFVPNWFVSPSKWVEEDKKISKDEPWREFYLGPRDRLYRTGDLGRYLPTGDCEVSGR ADDQVKIR" PFAM_domain 20751..22148 /aSDomain="AMP-binding" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00501.31" /description="AMP-binding enzyme" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0153_0020" /evalue="7.60E-67" /label="PAS_chr1-4_0153" /locus_tag="PAS_chr1-4_0153" /protein_end="716" /protein_start="250" /score="225.9" /tool="antismash" /translation="FSDNAEKFPDRTCVVETKSFLNPNSQTRTFTYKQIDQASNIVGNY LVHTGIKRGDVVMIYAYRGVDLMVAVMGVLKAGATFSVIDPAYPPARQNVYLQVAKPAG LIVLEKAGVLDQLVEDYIKNELSLVSRISNLKIEADGNVLGGDVDGKDALYDYQQFKTR RTGVLVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAYYFPWMSKTFNLSENDKFTMLSGI AHDPIQRDMFTPLFLGAQLLIPTSDDIGTPGKLAEWMQTYGATVTHLTPAMGQLLSAQA TKEIPSLHHAFFVGDILTKRDCLRLQTIAQNVNIINMYGTTETQRAVSYFEIPSRAQDS TFLEVQKDIMPAGKGMHNVQLLVVNRHDRSKTCAIGEVGEIYVRAAGLAEQYRGQPDLN KEKFVPNWFVSPSKWVEEDKKISKDEPWREFYLGPRDRLYRTGDLGRYLPTGDCEVSGR ADDQVKIR" aSModule 20751..23702 /complete /domains="nrpspksdomains_PAS_chr1-4_0153_AMP-binding.1" /domains="nrpspksdomains_PAS_chr1-4_0153_PCP.1" /domains="nrpspksdomains_PAS_chr1-4_0153_NAD_binding_4.1" /locus_tags="PAS_chr1-4_0153" /monomer_pairings="Aad -> Aad" /starter_module /tool="antismash" /type="nrps" aSDomain 20841..22217 /aSDomain="TIGR01733" /aSTool="tigrfam" /description="AA-adenyl-dom: amino acid adenylation domain" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0153_0005" /evalue="2.00E-114" /identifier="TIGR01733" /label="PAS_chr1-4_0153" /locus_tag="PAS_chr1-4_0153" /protein_end="739" /protein_start="280" /score="380.6" /tool="antismash" /translation="TYKQIDQASNIVGNYLVHTGIKRGDVVMIYAYRGVDLMVAVMGVL KAGATFSVIDPAYPPARQNVYLQVAKPAGLIVLEKAGVLDQLVEDYIKNELSLVSRISN LKIEADGNVLGGDVDGKDALYDYQQFKTRRTGVLVGPDSNPTLSFTSGSEGIPKGVLGR HFSLAYYFPWMSKTFNLSENDKFTMLSGIAHDPIQRDMFTPLFLGAQLLIPTSDDIGTP GKLAEWMQTYGATVTHLTPAMGQLLSAQATKEIPSLHHAFFVGDILTKRDCLRLQTIAQ NVNIINMYGTTETQRAVSYFEIPSRAQDSTFLEVQKDIMPAGKGMHNVQLLVVNRHDRS KTCAIGEVGEIYVRAAGLAEQYRGQPDLNKEKFVPNWFVSPSKWVEEDKKISKDEPWRE FYLGPRDRLYRTGDLGRYLPTGDCEVSGRADDQVKIRGFRIELGEIDTHISRHPLIRQN V" CDS_motif 21285..21332 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PAS_chr1-4_0153_0001" /evalue="8.40E-04" /label="NRPS-A_a3" /locus_tag="PAS_chr1-4_0153" /protein_end="444" /protein_start="428" /score="12.4" /tool="antismash" /translation="FTSGSEGIPKGVLGRH" CDS_motif 21474..21506 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PAS_chr1-4_0153_0002" /evalue="3.00E+01" /label="NRPS-A_a3" /locus_tag="PAS_chr1-4_0153" /protein_end="502" /protein_start="491" /score="-1.4" /tool="antismash" /translation="LIPTSDDIGTP" CDS_motif 21873..21959 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PAS_chr1-4_0153_0003" /evalue="1.90E-07" /label="NRPS-A_a6" /locus_tag="PAS_chr1-4_0153" /protein_end="653" /protein_start="624" /score="23.4" /tool="antismash" /translation="IGEVGEIYVRAAGLAEQYRGQPDLNKEKF" CDS_motif 22119..22175 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PAS_chr1-4_0153_0004" /evalue="3.80E-11" /label="NRPS-A_a8" /locus_tag="PAS_chr1-4_0153" /protein_end="725" /protein_start="706" /score="35.0" /tool="antismash" /translation="GRADDQVKIRGFRIELGEI" aSDomain 22578..22784 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PAS_chr1-4_0153_PCP.1" /evalue="1.40E-17" /label="PAS_chr1-4_0153_PCP.1" /locus_tag="PAS_chr1-4_0153" /protein_end="928" /protein_start="859" /score="55.6" /tool="antismash" /translation="LQIKDLWLQVLPNPPASISLEDSFFDLGGHSILATRMIFELRRKL AVDLPLGTIFKHPTVKLFAAEVDR" PFAM_domain 22581..22772 /aSDomain="PP-binding" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00550.28" /description="Phosphopantetheine attachment site" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0153_0021" /evalue="2.30E-13" /label="PAS_chr1-4_0153" /locus_tag="PAS_chr1-4_0153" /protein_end="924" /protein_start="860" /score="50.4" /tool="antismash" /translation="QIKDLWLQVLPNPPASISLEDSFFDLGGHSILATRMIFELRRKLA VDLPLGTIFKHPTVKLFAA" aSDomain 22953..24095 /aSDomain="TIGR01746" /aSTool="tigrfam" /description="Thioester-redct: thioester reductase domain" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0153_0006" /evalue="1.20E-111" /identifier="TIGR01746" /label="PAS_chr1-4_0153" /locus_tag="PAS_chr1-4_0153" /protein_end="1365" /protein_start="984" /score="371.5" /tool="antismash" /translation="NIFLTGATGFLGSYILKDLLERDLDVQVYAHVRAKDEESGLERLR NTGKVYGIWNEEWTSRIKVVIADLSKDKLGLSGEKYAELANTIDLIIHNGALVHWVYPY SKLRDANVISTINVLNLAASGKPKQFGFVSSTSTLDTEHYITLSDTLTEQGEDGIPESD DLLGSSKGLGTGYGQSKWAAEYIIRRAFERGLRGAIIRPGYVTGHSRTGACNTDDFLLR MLKGCAELGKLPNISNTVNMVPVDHVALVVTASSLHPTAEEGHCVVQVTGHPRIRFNEF LNALNDYGYEVKLTDYVEWKRDLERFVVDQSKDSALYPLLHFVLDNLPQDTKAPELDDK NAKDILSGDTRWTGYDGSKGRGVDSAQTGIYIAYLIKTGFL" aSDomain 22962..23702 /aSDomain="NAD_binding_4" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PAS_chr1-4_0153_NAD_binding_4.1" /evalue="4.70E-77" /label="PAS_chr1-4_0153_NAD_binding_4.1" /locus_tag="PAS_chr1-4_0153" /protein_end="1234" /protein_start="987" /score="250.3" /tool="antismash" /translation="LTGATGFLGSYILKDLLERDLDVQVYAHVRAKDEESGLERLRNTG KVYGIWNEEWTSRIKVVIADLSKDKLGLSGEKYAELANTIDLIIHNGALVHWVYPYSKL RDANVISTINVLNLAASGKPKQFGFVSSTSTLDTEHYITLSDTLTEQGEDGIPESDDLL GSSKGLGTGYGQSKWAAEYIIRRAFERGLRGAIIRPGYVTGHSRTGACNTDDFLLRMLK GCAELGKLPNISNTVNMVPVDHVAL" PFAM_domain 22962..23702 /aSDomain="NAD_binding_4" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF07993.15" /description="Male sterility protein" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0153_0022" /evalue="4.60E-77" /label="PAS_chr1-4_0153" /locus_tag="PAS_chr1-4_0153" /protein_end="1234" /protein_start="987" /score="258.8" /tool="antismash" /translation="LTGATGFLGSYILKDLLERDLDVQVYAHVRAKDEESGLERLRNTG KVYGIWNEEWTSRIKVVIADLSKDKLGLSGEKYAELANTIDLIIHNGALVHWVYPYSKL RDANVISTINVLNLAASGKPKQFGFVSSTSTLDTEHYITLSDTLTEQGEDGIPESDDLL GSSKGLGTGYGQSKWAAEYIIRRAFERGLRGAIIRPGYVTGHSRTGACNTDDFLLRMLK GCAELGKLPNISNTVNMVPVDHVAL" gene complement(<24228..>26678) /db_xref="GeneID:8197138" /locus_tag="PAS_chr1-4_0154" mRNA complement(<24228..>26678) /db_xref="GeneID:8197138" /locus_tag="PAS_chr1-4_0154" /product="Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p)" /transcript_id="XM_002490220.1" CDS complement(24228..26678) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0154" /db_xref="EnsemblGenomes-Tr:CAY67984" /db_xref="GeneID:8197138" /db_xref="GOA:C4QXL1" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001841" /db_xref="InterPro:IPR013083" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR017907" /db_xref="InterPro:IPR018957" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:C4QXL1" /locus_tag="PAS_chr1-4_0154" /product="Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p)" /protein_id="XP_002490265.1" /transl_table=1 /translation="MTKASEAGGFIVDDPDYKKPARRRRAAKKAVSYVETDDELPPNGT SSSKSSRKRKVKDESEDEEYQESLGTDKVDDIKPEDDEEEDAIVIRGTSTGRNRPNGAS IVNAISLSDLSDLSDLEQNIDIPEELEELDLEVVEEAEAPRPKKKRKTPAKPKKPRVPY FTRVTEKLYNIHPSLKDVFPNLDQHEQIEVKKATQPEGMTCTLLPFQLEGLNWLVKQEE SEFGGGVLADEMGMGKTIQTIALFMHDRTKSPNLVIAPTVALMQWKSEIELHTNGILKV GVFHGQNRGKSAEELKEYDVILTTYSVLESVYRKQNYGFKRKRGLVKEPSPLHNTHFYR VILDEAHNIKDRQSGTAKAANSLDTEKRWCLSGTPLQNRIGEMYSLIRFMKLYPFCEYF CTKCDCRSTEWKFTNWKCCDTCGHTPMLHTNFFNHFMLKNIQKYGVEGLGLESFKNIRL LLKNIMLRRTKVQRADDLGLPPRIVEIRRDRFNEEEKDLYASLYSDSKRKFNDYVAEGV VLNNYANIFTLITRMRQLADHPDLVLRRVGTNSIDSSGMPEGVIVCQLCDDEAEEPIES KCHHKFCRLCVSEYVEGFNGDPNKLECPVCHLALSIDLEGPAIEVDLELIKKGSIVNRI RMGGEWRSSTKIEALVEELFHLRSDRVTIKSIVFSQFTSMLDLVEWRLKRAGFETVKLQ GSMSPLQRESTIKHFMETPSVEVFLVSLKAGGVALNLCEASQVFILDPWWNPSVEWQSG DRVHRIGQHRPVKITRFCIEDSIESRIIELQDKKANMIHATINQDDAAISRLTPSDLQF LFMN" PFAM_domain complement(24399..24743) /aSDomain="Helicase_C" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00271.34" /description="Helicase conserved C-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0154_0025" /evalue="5.70E-13" /label="PAS_chr1-4_0154" /locus_tag="PAS_chr1-4_0154" /protein_end="760" /protein_start="645" /score="49.3" /tool="antismash" /translation="KIEALVEELFHLRSDRVTIKSIVFSQFTSMLDLVEWRLKRAGFET VKLQGSMSPLQRESTIKHFMETPSVEVFLVSLKAGGVALNLCEASQVFILDPWWNPSVE WQSGDRVHRIG" PFAM_domain complement(24861..24992) /aSDomain="zf-C3HC4" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00097.28" /db_xref="GO:0046872" /description="Zinc finger, C3HC4 type (RING finger)" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0154_0024" /evalue="3.90E-07" /gene_ontologies="GO:0046872: metal ion binding" /label="PAS_chr1-4_0154" /locus_tag="PAS_chr1-4_0154" /protein_end="606" /protein_start="562" /score="29.9" /tool="antismash" /translation="CQLCDDEAEEPIESKCHHKFCRLCVSEYVEGFNGDPNKLECPVC" PFAM_domain complement(25053..26024) /aSDomain="SNF2-rel_dom" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00176.26" /db_xref="GO:0005524" /db_xref="GO:0140658" /description="SNF2-related domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0154_0023" /evalue="1.10E-54" /gene_ontologies="GO:0005524: ATP binding" /gene_ontologies="GO:0140658: ATP-dependent chromatin remodeler activity" /label="PAS_chr1-4_0154" /locus_tag="PAS_chr1-4_0154" /protein_end="542" /protein_start="218" /score="185.6" /tool="antismash" /translation="KQEESEFGGGVLADEMGMGKTIQTIALFMHDRTKSPNLVIAPTVA LMQWKSEIELHTNGILKVGVFHGQNRGKSAEELKEYDVILTTYSVLESVYRKQNYGFKR KRGLVKEPSPLHNTHFYRVILDEAHNIKDRQSGTAKAANSLDTEKRWCLSGTPLQNRIG EMYSLIRFMKLYPFCEYFCTKCDCRSTEWKFTNWKCCDTCGHTPMLHTNFFNHFMLKNI QKYGVEGLGLESFKNIRLLLKNIMLRRTKVQRADDLGLPPRIVEIRRDRFNEEEKDLYA SLYSDSKRKFNDYVAEGVVLNNYANIFTLITRMRQLADHPDLV" gene complement(<27038..>30091) /db_xref="GeneID:8197139" /locus_tag="PAS_chr1-4_0155" mRNA complement(<27038..>30091) /db_xref="GeneID:8197139" /locus_tag="PAS_chr1-4_0155" /product="Hypothetical protein" /transcript_id="XM_002490221.1" CDS complement(27038..30091) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0155" /db_xref="EnsemblGenomes-Tr:CAY67985" /db_xref="GeneID:8197139" /db_xref="GOA:C4QXL2" /db_xref="InterPro:IPR003101" /db_xref="InterPro:IPR008626" /db_xref="UniProtKB/TrEMBL:C4QXL2" /locus_tag="PAS_chr1-4_0155" /product="Hypothetical protein" /protein_id="XP_002490266.1" /transl_table=1 /translation="MNGLPQQPWHSELNPKERQGFINIIVQSVFQIQGNNSFNNAKTKQ LAEDFEKWAFSNARSKKEYVDMLRNKVSSIKQAAVNGRSSMAANAPDPAATLNGMQSMG QQNIPVQPQMQQHQQQNQYMKNNQQQQPQQQQQQQQPQRPMMNNFSNDQRVNLKTAPIP EALLKRIPGLPVGVNTWAQITQMLQNGQINPQLMNTIKQVYTVHSQLLQARSHQDAMQK PPQQPQVQTQPQTQPQPQRDQMFMQQNRMANNQQHIQQQAQNPQFNSKLVQGQQQQQPQ QPPQQSATQQPQLQITQEMLREGTTQALNLIERLKQTGDLPQTLAPAQQQSFIKTFIQR HYLPRVLQNKNATANPSSQQANNQNSVPQAVPGFPGQSVPLQQAQKFVNTSPLMNQTLP TTFNNARPMQKPQQQKQPQQSVPSNSMFGALPNAQQPVPNMHQQQQKQPIKLLPGIQAT EEDWTNLRKVYAEALQLPIKLKNVTNEITPDQKRAVLDQAKTMIQLSITTENLIPNFFI ATKNVEGTRRLIQIKFMLKEVLESLKRNEYLATPNILQRVQTQIHKYITYLKELQQRKF QQLQNVQSLQQQQQQQQQTSNLQQVPQMGQGNKQLPNNMLYTSQTNPDSLMGGSNANNM FSGLGIQDPSLNNTAAFSQQQRVTPASGQQLNSSPLMQTPMLNQNSLMPNQIQQFPPQQ QQHRQQQRALPQQRLAQQVQTSPNAKPQQYMQQLPNNMPQPQHSQQPYQASLEQQVPQQ MLQQPQQRQQLQQQVPIQQVQQAKRKVKSSVSGPSTGAPGKQAKVQGNRMAATNAAAKS SPVVMATPSSVQSPENLVATKEQNEIQAKEEAESAAINTSRMRIKELGLDDPASYFLCM LSRSLDLKDEETQLLDSKESNSVKKDTISQKGITPSAILQTPLSFIKTPGSSRPLDSPS TSKNANEWSSKVTPAAINAVFRDVSAISKTLSFGMLPTPPEENEVLKRSSDADEEPSKK AKLENKLQNSLWDFDYAEELFATDHLSP" PFAM_domain complement(28382..28717) /aSDomain="Med15_fungi" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF05397.15" /db_xref="GO:0003712" /db_xref="GO:0006357" /db_xref="GO:0016592" /description="Mediator complex subunit 15" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0155_0028" /evalue="1.30E-30" /gene_ontologies="GO:0003712: transcription coregulator activity" /gene_ontologies="GO:0006357: regulation of transcription by RNA polymerase II" /gene_ontologies="GO:0016592: mediator complex" /label="PAS_chr1-4_0155" /locus_tag="PAS_chr1-4_0155" /protein_end="570" /protein_start="458" /score="106.0" /tool="antismash" /translation="EEDWTNLRKVYAEALQLPIKLKNVTNEITPDQKRAVLDQAKTMIQ LSITTENLIPNFFIATKNVEGTRRLIQIKFMLKEVLESLKRNEYLATPNILQRVQTQIH KYITYLKE" PFAM_domain complement(29441..29641) /aSDomain="Gal11_ABD1" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF18535.4" /description="Gal11 activator-binding domain (ABD1)" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0155_0027" /evalue="6.40E-14" /label="PAS_chr1-4_0155" /locus_tag="PAS_chr1-4_0155" /protein_end="217" /protein_start="150" /score="51.9" /tool="antismash" /translation="NDQRVNLKTAPIPEALLKRIPGLPVGVNTWAQITQMLQNGQINPQ LMNTIKQVYTVHSQLLQARSHQ" PFAM_domain complement(29837..30073) /aSDomain="KIX_2" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF16987.8" /description="KIX domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0155_0026" /evalue="2.00E-16" /label="PAS_chr1-4_0155" /locus_tag="PAS_chr1-4_0155" /protein_end="85" /protein_start="6" /score="59.9" /tool="antismash" /translation="QPWHSELNPKERQGFINIIVQSVFQIQGNNSFNNAKTKQLAEDFE KWAFSNARSKKEYVDMLRNKVSSIKQAAVNGRSS" gene <31016..>31489 /db_xref="GeneID:8197140" /locus_tag="PAS_chr1-4_0156" mRNA <31016..>31489 /db_xref="GeneID:8197140" /locus_tag="PAS_chr1-4_0156" /product="Hypothetical protein" /transcript_id="XM_002490222.1" CDS 31016..31489 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0156" /db_xref="EnsemblGenomes-Tr:CAY67986" /db_xref="GeneID:8197140" /db_xref="InterPro:IPR025355" /db_xref="UniProtKB/TrEMBL:C4QXL3" /locus_tag="PAS_chr1-4_0156" /product="Hypothetical protein" /protein_id="XP_002490267.1" /transl_table=1 /translation="MGAWVMDVFHDHTSLDFLDNLLKSQDQVKFVVDSLAAPVPQTLED GEIDCSESFQKLMSAIFLAIWLDFDTKIPLAKAKYSGHITDGIEETYDKVKDSPDFQEL EKQGQFFKNQAKQWLKSLSENPELSELCELWIKDPENYKKWKENIDWVIDFVS" PFAM_domain 31019..31456 /aSDomain="DUF4259" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF14078.9" /description="Domain of unknown function (DUF4259)" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0156_0029" /evalue="2.70E-29" /label="PAS_chr1-4_0156" /locus_tag="PAS_chr1-4_0156" /protein_end="147" /protein_start="1" /score="102.8" /tool="antismash" /translation="GAWVMDVFHDHTSLDFLDNLLKSQDQVKFVVDSLAAPVPQTLEDG EIDCSESFQKLMSAIFLAIWLDFDTKIPLAKAKYSGHITDGIEETYDKVKDSPDFQELE KQGQFFKNQAKQWLKSLSENPELSELCELWIKDPENYKKWKE" gene complement(<31583..>32020) /db_xref="GeneID:8197141" /locus_tag="PAS_chr1-4_0157" mRNA complement(<31583..>32020) /db_xref="GeneID:8197141" /locus_tag="PAS_chr1-4_0157" /product="Hypothetical protein" /transcript_id="XM_002490223.1" CDS complement(31583..32020) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0157" /db_xref="EnsemblGenomes-Tr:CAY67987" /db_xref="GeneID:8197141" /db_xref="UniProtKB/TrEMBL:C4QXL4" /locus_tag="PAS_chr1-4_0157" /product="Hypothetical protein" /protein_id="XP_002490268.1" /transl_table=1 /translation="MDQENSQLRNFHGLLVLARLLDDYISKTLQQDAVKDDTMVQNDLK WTQTEIKETISRVSPLASTLTSNNSSSNAEKKEIFVQVCAYFGGVLDNVIVIFKETTEL SMLPTLETLQNNLCAIESGGDAGGDLSLLIKEAIEQLQRQR" gene complement(<32204..>32857) /db_xref="GeneID:8197142" /locus_tag="PAS_chr1-4_0158" mRNA complement(<32204..>32857) /db_xref="GeneID:8197142" /locus_tag="PAS_chr1-4_0158" /product="Clathrin light chain" /transcript_id="XM_002490224.1" CDS complement(32204..32857) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0158" /db_xref="EnsemblGenomes-Tr:CAY67988" /db_xref="GeneID:8197142" /db_xref="GOA:C4QXL5" /db_xref="InterPro:IPR000996" /db_xref="UniProtKB/TrEMBL:C4QXL5" /locus_tag="PAS_chr1-4_0158" /product="Clathrin light chain" /protein_id="XP_002490269.1" /transl_table=1 /translation="MADKFPELKDVDTGASSGESPSQGDFLSREKELLGDEFTTERDQE LADDNVDEFDEFESNFPKVDADQEESIPVEDAPEEEAHTPLHSTFDNLDLKESKPIQEW KERTELEISKRDEVAAKKHEEIKKQAEKDVDDFYVNYNDKKEKSLKATKEDEEKFIAKR DSFFDQGSVWDRTVELLKLKKNSSFGADEADKTRFKEILLSLKGKENVPGAAGY" PFAM_domain complement(32216..32845) /aSDomain="Clathrin_lg_ch" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01086.20" /db_xref="GO:0005198" /db_xref="GO:0006886" /db_xref="GO:0016192" /db_xref="GO:0030130" /db_xref="GO:0030132" /description="Clathrin light chain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0158_0030" /evalue="1.10E-56" /gene_ontologies="GO:0005198: structural molecule activity" /gene_ontologies="GO:0006886: intracellular protein transport" /gene_ontologies="GO:0016192: vesicle-mediated transport" /gene_ontologies="GO:0030130: clathrin coat of trans-Golgi network vesicle" /gene_ontologies="GO:0030132: clathrin coat of coated pit" /label="PAS_chr1-4_0158" /locus_tag="PAS_chr1-4_0158" /protein_end="214" /protein_start="4" /score="192.6" /tool="antismash" /translation="FPELKDVDTGASSGESPSQGDFLSREKELLGDEFTTERDQELADD NVDEFDEFESNFPKVDADQEESIPVEDAPEEEAHTPLHSTFDNLDLKESKPIQEWKERT ELEISKRDEVAAKKHEEIKKQAEKDVDDFYVNYNDKKEKSLKATKEDEEKFIAKRDSFF DQGSVWDRTVELLKLKKNSSFGADEADKTRFKEILLSLKGKENVPGA" gene <33062..>34189 /db_xref="GeneID:8197143" /locus_tag="PAS_chr1-4_0159" mRNA <33062..>34189 /db_xref="GeneID:8197143" /locus_tag="PAS_chr1-4_0159" /product="Protein that interacts with exonuclease Rat1p and Rai1p" /transcript_id="XM_002490225.1" CDS 33062..34189 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0159" /db_xref="EnsemblGenomes-Tr:CAY67989" /db_xref="GeneID:8197143" /db_xref="GOA:C4QXL6" /db_xref="InterPro:IPR006569" /db_xref="InterPro:IPR006903" /db_xref="InterPro:IPR008942" /db_xref="UniProtKB/TrEMBL:C4QXL6" /locus_tag="PAS_chr1-4_0159" /product="Protein that interacts with exonuclease Rat1p and Rai1p" /protein_id="XP_002490270.1" /transl_table=1 /translation="MSYSKDIVLEKLASLEETQISIQSIGQWCLFHHRHAPETVAIWSE FVGSTQTKKLAGLYLANEIIQQSRAKRKTTFLDEFAKVLPSTLEQIYPSMISTHQAKLK RIIDVWSQRKIFDSNLIHRLYQSIQDQKAYNGLSSSSSNSPPINSGDLAPEISSLSTLF NKISTLKSSTSLVVNQINEQYSSLFDSETLPGTDIYLKQLGDLSTLITSARSKSQETQE LRESIINELKKLIQVQESWITKDAESSGSLDEKLATVQQKESELKEFINDVEEEDGVPQ YAASSDEEGDENVSKKRKMESPPTETVDSGEQPTNPVHPQLSSILESLSRTTGLTPEPA STSDESATATQKQDETPVSSSINPALASLLSKLNG" PFAM_domain 33083..33433 /aSDomain="CID" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04818.16" /description="CID domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0159_0031" /evalue="2.80E-32" /label="PAS_chr1-4_0159" /locus_tag="PAS_chr1-4_0159" /protein_end="124" /protein_start="7" /score="111.7" /tool="antismash" /translation="VLEKLASLEETQISIQSIGQWCLFHHRHAPETVAIWSEFVGSTQT KKLAGLYLANEIIQQSRAKRKTTFLDEFAKVLPSTLEQIYPSMISTHQAKLKRIIDVWS QRKIFDSNLIHRL" gene <34385..>36916 /db_xref="GeneID:8197144" /locus_tag="PAS_chr1-4_0160" mRNA <34385..>36916 /db_xref="GeneID:8197144" /locus_tag="PAS_chr1-4_0160" /product="Multifunctional enzyme HIS4" /transcript_id="XM_002490226.1" CDS 34385..36916 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0160" /db_xref="EnsemblGenomes-Tr:CAY67990" /db_xref="GeneID:8197144" /db_xref="GOA:C4QXL7" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016298" /db_xref="InterPro:IPR021130" /db_xref="UniProtKB/TrEMBL:C4QXL7" /locus_tag="PAS_chr1-4_0160" /product="Multifunctional enzyme HIS4" /protein_id="XP_002490271.1" /transl_table=1 /translation="MTFPLLPAYASVAEFDNSLSLVGKAVFPYAADQLHNLIKFTQSTE LQVNVQVESSVTEDQFEELIDNLLKLYNNGINEVILDLDLAERVVQRIPGARVIYRTLV DKVASLPANASIAVPFSSPLGDLKSFTNGGSRTVYAFSETAKLVDVTSTVASGIIPIID ARQLTTEYELSEDVKKFPVSEILLASLTTDRPDGLFTTLVADSSNYSLGLVYSSKKSIP EAIRTQTGVYQSRRHGLWYKGATSGATQKLLGIELDCDGDCLKFVVEQTGVGFCHLERT SCFGQSKGLRAMEATLWDRKSNAPEGSYTKRLFDDEVLLNAKIREEADELAEAKSKEDI AWECADLFYFALVRCAKYGVTLDEVERNLDMKSLKVTRRKGDAKPGYTKEQPKEESKPK EVPSEGRIELCKIDVSKASSQEIEDALRRPIQKTEQIMELVKPIVDNVRQNGDKALLEL TAKFDGVALKTPVLEAPFPEELMQLPDNVKRAIDLSIDNVRKFHEAQLTETLQVETCPG VVCSRFARPIEKVGLYIPGGTAILPSTSLMLGVPAKVAGRKEIVFASPPKKDGTLTPEV IYVAHKVGAKCIVLAGGAQAVAAMAYGTETVPKCDKIFGPGNQFVTAAKMMVQNDTSAL CSIDMPAGPSEVLVIADKYADPDFVASDLLSQAEHGIDSQVILLAVDMTDKELARIEDA VHNQAVQLPRVEIVRKCIAHSTTLSVATYEQALEMSNQYAPEHLILQIENASSYVDQVQ HAGSVFVGAYSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQDVTPEGLKH IGQAVMDLAAVEGLDAHRNAVKVRMEKLGLI" PFAM_domain 35021..35236 /aSDomain="PRA-CH" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01502.21" /db_xref="GO:0000105" /db_xref="GO:0004635" /description="Phosphoribosyl-AMP cyclohydrolase" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0160_0032" /evalue="1.00E-22" /gene_ontologies="GO:0000105: histidine biosynthetic process" /gene_ontologies="GO:0004635: phosphoribosyl-AMP cyclohydrolase activity" /label="PAS_chr1-4_0160" /locus_tag="PAS_chr1-4_0160" /protein_end="284" /protein_start="212" /score="79.9" /tool="antismash" /translation="LVYSSKKSIPEAIRTQTGVYQSRRHGLWYKGATSGATQKLLGIEL DCDGDCLKFVVEQTGVGFCHLERTSCF" aSDomain 35252..35491 /aSDomain="TIGR03188" /aSTool="tigrfam" /description="histidine_hisI: phosphoribosyl-ATP diphosphatase" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0160_0008" /evalue="5.80E-20" /identifier="TIGR03188" /label="PAS_chr1-4_0160" /locus_tag="PAS_chr1-4_0160" /protein_end="369" /protein_start="289" /score="69.3" /tool="antismash" /translation="LRAMEATLWDRKSNAPEGSYTKRLFDDEVLLNAKIREEADELAEA KSKEDIAWECADLFYFALVRCAKYGVTLDEVERNL" PFAM_domain 35252..35497 /aSDomain="PRA-PH" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01503.20" /description="Phosphoribosyl-ATP pyrophosphohydrolase" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0160_0033" /evalue="1.10E-16" /label="PAS_chr1-4_0160" /locus_tag="PAS_chr1-4_0160" /protein_end="371" /protein_start="289" /score="61.2" /tool="antismash" /translation="LRAMEATLWDRKSNAPEGSYTKRLFDDEVLLNAKIREEADELAEA KSKEDIAWECADLFYFALVRCAKYGVTLDEVERNLDM" PFAM_domain 35663..36895 /aSDomain="Histidinol_dh" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00815.23" /db_xref="GO:0016616" /db_xref="GO:0046872" /db_xref="GO:0051287" /description="Histidinol dehydrogenase" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0160_0034" /evalue="2.30E-160" /gene_ontologies="GO:0016616: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" /gene_ontologies="GO:0046872: metal ion binding" /gene_ontologies="GO:0051287: NAD binding" /label="PAS_chr1-4_0160" /locus_tag="PAS_chr1-4_0160" /protein_end="837" /protein_start="426" /score="534.2" /tool="antismash" /translation="RRPIQKTEQIMELVKPIVDNVRQNGDKALLELTAKFDGVALKTPV LEAPFPEELMQLPDNVKRAIDLSIDNVRKFHEAQLTETLQVETCPGVVCSRFARPIEKV GLYIPGGTAILPSTSLMLGVPAKVAGRKEIVFASPPKKDGTLTPEVIYVAHKVGAKCIV LAGGAQAVAAMAYGTETVPKCDKIFGPGNQFVTAAKMMVQNDTSALCSIDMPAGPSEVL VIADKYADPDFVASDLLSQAEHGIDSQVILLAVDMTDKELARIEDAVHNQAVQLPRVEI VRKCIAHSTTLSVATYEQALEMSNQYAPEHLILQIENASSYVDQVQHAGSVFVGAYSPE SCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQDVTPEGLKHIGQAVMDLAAVEG LDAHRNAVKVRM" aSDomain 35702..36892 /aSDomain="TIGR00069" /aSTool="tigrfam" /description="hisD: histidinol dehydrogenase" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0160_0007" /evalue="2.00E-149" /identifier="TIGR00069" /label="PAS_chr1-4_0160" /locus_tag="PAS_chr1-4_0160" /protein_end="836" /protein_start="439" /score="496.1" /tool="antismash" /translation="VKPIVDNVRQNGDKALLELTAKFDGVALKTPVLEAPFPEELMQLP DNVKRAIDLSIDNVRKFHEAQLTETLQVETCPGVVCSRFARPIEKVGLYIPGGTAILPS TSLMLGVPAKVAGRKEIVFASPPKKDGTLTPEVIYVAHKVGAKCIVLAGGAQAVAAMAY GTETVPKCDKIFGPGNQFVTAAKMMVQNDTSALCSIDMPAGPSEVLVIADKYADPDFVA SDLLSQAEHGIDSQVILLAVDMTDKELARIEDAVHNQAVQLPRVEIVRKCIAHSTTLSV ATYEQALEMSNQYAPEHLILQIENASSYVDQVQHAGSVFVGAYSPESCGDYSSGTNHTL PTYGYARQYSGVNTATFQKFITSQDVTPEGLKHIGQAVMDLAAVEGLDAHRNAVKVR" gene <37042..>38217 /db_xref="GeneID:8197145" /locus_tag="PAS_chr1-4_0161" mRNA <37042..>38217 /db_xref="GeneID:8197145" /locus_tag="PAS_chr1-4_0161" /product="Nuclear fusion protein BIK1" /transcript_id="XM_002490227.1" CDS 37042..38217 /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0161" /db_xref="EnsemblGenomes-Tr:CAY67991" /db_xref="GeneID:8197145" /db_xref="InterPro:IPR000938" /db_xref="UniProtKB/TrEMBL:C4QXL8" /locus_tag="PAS_chr1-4_0161" /product="Nuclear fusion protein BIK1" /protein_id="XP_002490272.1" /transl_table=1 /translation="MELHVPLGSEIVLPGGERAILKFVGNVESKSGIFAGVELIGQMSG KGKNSGEFKNVQYFTTKVPNSGIFLPYQRLLETSNMQRLQAETPTKTKRNVYVSRSPLA VSNQQGLKRSSKESSPSTVAGNEGQLHSLKTENTHLSQKCLKLETQLQECTEVLESMEK VIKDHYEPAFNQMEKDLSEKNEKISKLKVSFDEQKTELLDIIDSLEKQASETEQLYTKE LKRLREECAAYKNKDTAKETNELQRQLKVKEKMCQDWELKYTQLKDSKSKEENDIIQGY QREIDDLKAKLSSSQKAQPEKNTEIEEQLQRLKAENRSLQQQLETAREKEKIQPLTSTT TEQSTLLDENGNLQIFVPKNSDPANGRKKWCGLCEREGHDSVQCPFENDMF" PFAM_domain 37063..37263 /aSDomain="CAP_GLY" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01302.28" /description="CAP-Gly domain" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0161_0035" /evalue="1.50E-13" /label="PAS_chr1-4_0161" /locus_tag="PAS_chr1-4_0161" /protein_end="74" /protein_start="7" /score="50.6" /tool="antismash" /translation="GSEIVLPGGERAILKFVGNVESKSGIFAGVELIGQMSGKGKNSGE FKNVQYFTTKVPNSGIFLPYQR" gene complement(<38302..>38988) /db_xref="GeneID:8197146" /locus_tag="PAS_chr1-4_0162" mRNA complement(join(<38302..38864,38931..>38988)) /db_xref="GeneID:8197146" /locus_tag="PAS_chr1-4_0162" /product="GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5" /transcript_id="XM_002490228.1" CDS complement(join(38302..38864,38931..38988)) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0162" /db_xref="EnsemblGenomes-Tr:CAY67992" /db_xref="GeneID:8197146" /db_xref="GOA:C4QXL9" /db_xref="InterPro:IPR001806" /db_xref="InterPro:IPR003579" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:C4QXL9" /locus_tag="PAS_chr1-4_0162" /product="GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5" /protein_id="XP_002490273.1" /transl_table=1 /translation="MADLVTQEPRFAQFKLVLLGESAVGKSSIVHRFVTDSFDDLREST IGAAFLTQTIQLDERTTIKFEIWDTAGQERYKSLAPMYYRNANCALVAYDITQESSLDR AKSWIQELQKQASADIVVALVGNKLDLEAERKVSTKEAKEYADELGLIFKEISAKTGEG IKDVFHSIASKLPVEEKLNSATKRRRNIDLNRPSTNNQESCSC" PFAM_domain complement(join(38398..38864,38931..38946)) /aSDomain="Ras" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00071.25" /db_xref="GO:0003924" /db_xref="GO:0005525" /description="Ras family" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0162_0036" /evalue="6.00E-59" /gene_ontologies="GO:0003924: GTPase activity" /gene_ontologies="GO:0005525: GTP binding" /label="PAS_chr1-4_0162" /locus_tag="PAS_chr1-4_0162" /protein_end="175" /protein_start="14" /score="198.4" /tool="antismash" /translation="KLVLLGESAVGKSSIVHRFVTDSFDDLRESTIGAAFLTQTIQLDE RTTIKFEIWDTAGQERYKSLAPMYYRNANCALVAYDITQESSLDRAKSWIQELQKQASA DIVVALVGNKLDLEAERKVSTKEAKEYADELGLIFKEISAKTGEGIKDVFHSIASKL" aSDomain complement(join(38413..38864,38931..38952)) /aSDomain="TIGR00231" /aSTool="tigrfam" /description="small_GTP: small GTP-binding protein domain" /detection="hmmscan" /domain_id="TIGRFam_PAS_chr1-4_0162_0009" /evalue="4.90E-28" /identifier="TIGR00231" /label="PAS_chr1-4_0162" /locus_tag="PAS_chr1-4_0162" /protein_end="170" /protein_start="12" /score="95.9" /tool="antismash" /translation="QFKLVLLGESAVGKSSIVHRFVTDSFDDLRESTIGAAFLTQTIQL DERTTIKFEIWDTAGQERYKSLAPMYYRNANCALVAYDITQESSLDRAKSWIQELQKQA SADIVVALVGNKLDLEAERKVSTKEAKEYADELGLIFKEISAKTGEGIKDVFHS" gene complement(<39207..>39580) /db_xref="GeneID:8197147" /locus_tag="PAS_chr1-4_0163" mRNA complement(join(<39207..39518,39578..>39580)) /db_xref="GeneID:8197147" /locus_tag="PAS_chr1-4_0163" /product="uncharacterized protein" /transcript_id="XM_002490229.1" CDS complement(join(39207..39518,39578..39580)) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0163" /db_xref="EnsemblGenomes-Tr:CAY67993" /db_xref="GeneID:8197147" /db_xref="GOA:C4QXM0" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="UniProtKB/TrEMBL:C4QXM0" /locus_tag="PAS_chr1-4_0163" /product="uncharacterized protein" /protein_id="XP_002490274.1" /transl_table=1 /translation="MSTLLKSANSLKPLLNRVLVQRAKAATKTASGIYIPEKNVEKLHQ ATVIATGPGVPNQNGSLEPTIVKAGDNVLIPSFGGSPVKINDEEYLLFSDREILAKIEN " PFAM_domain complement(39216..39491) /aSDomain="Cpn10" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00166.24" /db_xref="GO:0005524" /db_xref="GO:0006457" /db_xref="GO:0044183" /description="Chaperonin 10 Kd subunit" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0163_0037" /evalue="3.50E-27" /gene_ontologies="GO:0005524: ATP binding" /gene_ontologies="GO:0006457: protein folding" /gene_ontologies="GO:0044183: protein folding chaperone" /label="PAS_chr1-4_0163" /locus_tag="PAS_chr1-4_0163" /protein_end="102" /protein_start="10" /score="94.4" /tool="antismash" /translation="LKPLLNRVLVQRAKAATKTASGIYIPEKNVEKLHQATVIATGPGV PNQNGSLEPTIVKAGDNVLIPSFGGSPVKINDEEYLLFSDREILAKI" gene complement(<39772..>41631) /db_xref="GeneID:8197148" /locus_tag="PAS_chr1-4_0695" mRNA complement(<39772..>41631) /db_xref="GeneID:8197148" /locus_tag="PAS_chr1-4_0695" /product="uncharacterized protein" /transcript_id="XM_002490230.1" CDS complement(39772..41631) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0695" /db_xref="EnsemblGenomes-Tr:CAY67994" /db_xref="GeneID:8197148" /db_xref="UniProtKB/TrEMBL:C4QXM1" /locus_tag="PAS_chr1-4_0695" /product="uncharacterized protein" /protein_id="XP_002490275.1" /transl_table=1 /translation="MTEQLIEWFRDPSNKAYWNEDLVAIRESPLGGVGVFAKEKIGHDE EDDEENLLLRVSKQSILSGKNSFISNLLHECGADSHLGLILAFLYEKSLGSDSPWYAYL QTIQPKNTKGLILPVHLWPDEKKNLLIGTELYSVLDNFEEETEGLFESCVSFAREYESV LKVPTELAVDENNAKEKLLEFAAITLAIASRSFNVDNYHELALVPGADLFNHDSYGREH VHFEALGDVCPFCASCDECGHIEHGAPDSEIESDLEQEGDNEEDEEDKVHDDADTEDGM EDNKKEGNNEPFEVTEDYITKLEKELEREDMSDEESDASEAEGHDNSDSDMSDIDEDSL LIPDVCCDIKIVKSIPKNKELLNTYGDLNNTSLLTKYGFTSLNNPNDYVSLGDQALSQL KNFPDRKDWWDSKGYEVFNDYLHYTAQLNQEEYDNEGVEDKEEKEGHKNGEEGDDQYHS DAECQSCNGDSQASPGSCCNSCDGGNDEGEEEEEEQPEYLPWQVELRVNAEGRPSQSTY ALARLLSLSEAEFQELREADDKTLFLEKIGTLESPEKAAYQNILNWCKQRSTAYQDGGL TSNDYEKAIRVTKDSQKLAISILVFGEKKVLEQSIASLTQQIN" gene complement(<41777..>42664) /db_xref="GeneID:8197439" /locus_tag="PAS_chr1-4_0164" mRNA complement(<41777..>42664) /db_xref="GeneID:8197439" /locus_tag="PAS_chr1-4_0164" /product="uncharacterized protein" /transcript_id="XM_002490231.1" CDS complement(41777..42664) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0164" /db_xref="EnsemblGenomes-Tr:CAY67995" /db_xref="GeneID:8197439" /db_xref="GOA:C4QXM2" /db_xref="InterPro:IPR001283" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR018244" /db_xref="UniProtKB/TrEMBL:C4QXM2" /locus_tag="PAS_chr1-4_0164" /product="uncharacterized protein" /protein_id="XP_002490276.1" /transl_table=1 /translation="MRLLHISLLSIISVLTKANAECCYTNTHTTTEVWYTTVYARDVSE ETSSTLAGGSATVSSEVSSTIESSVATSATTESSSETSGSTSGSTSATESSTGSSSLAT SSSITSSESSTITQTTGQESTSPTPSSSETGSSTTTPYDISPTASSDFDAFKYQILDEH NIKRALHGVDGLEWDEEVYAAAQAYADAYTCDGTLVHSGNSLYGENLAYGYSTRGTVDA WYSEIEYYDFNNPGYTPGVGHFTQVVWKSTTKLGCAFKYCNDYYGAYVVCNYSPPGNYV NEGYFEANVLPLVD" PFAM_domain complement(41843..42187) /aSDomain="CAP" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00188.29" /description="Cysteine-rich secretory protein family" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0164_0038" /evalue="2.40E-21" /label="PAS_chr1-4_0164" /locus_tag="PAS_chr1-4_0164" /protein_end="274" /protein_start="159" /score="77.0" /tool="antismash" /translation="LDEHNIKRALHGVDGLEWDEEVYAAAQAYADAYTCDGTLVHSGNS LYGENLAYGYSTRGTVDAWYSEIEYYDFNNPGYTPGVGHFTQVVWKSTTKLGCAFKYCN DYYGAYVVCNY" gene complement(<43032..>44159) /db_xref="GeneID:8197149" /locus_tag="PAS_chr1-4_0165" mRNA complement(<43032..>44159) /db_xref="GeneID:8197149" /locus_tag="PAS_chr1-4_0165" /product="Class E protein of the vacuolar protein-sorting (Vps) pathway" /transcript_id="XM_002490232.1" CDS complement(43032..44159) /codon_start=1 /db_xref="EnsemblGenomes-Gn:PAS_chr1-4_0165" /db_xref="EnsemblGenomes-Tr:CAY67996" /db_xref="GeneID:8197149" /db_xref="InterPro:IPR019194" /db_xref="UniProtKB/TrEMBL:C4QXM3" /locus_tag="PAS_chr1-4_0165" /product="Class E protein of the vacuolar protein-sorting (Vps) pathway" /protein_id="XP_002490277.1" /transl_table=1 /translation="MSEVLDIPDGEYDLDISSLLCDDSVNLGVRYNFKPDSIDMDYPLE LVQESSNYILKAESDPNVRKEPLVFEGTLGKTNQHDYLLIYDDITKRFQMDRFNGVLRM NKSRAPDKLLTKFEKLKLGKDSPASGSRPYVATANHTALRKVTPFKLETKLKPTKPLEN RVHIHMKESKPKNSSSLTESVDKKKQEVSIPKVHLTPHTPSSILVSKAEHPKVASKRPP NTPLEFQDDSNDNNDNGDDDDDLTSFVGELEAEMGIETPPPTQERAGLVGIGISKSDKS TDQQSATQMELSKDSFHEDNWQPNYSDWESDLEEVPASNSINFFVDDDPKSKEFQNQAT YVNPEFHNTPASSVARPISMKELATTTFSQSSKSS" PFAM_domain complement(43830..44126) /aSDomain="EAF" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF09816.12" /description="RNA polymerase II transcription elongation factor" /detection="hmmscan" /domain_id="clusterhmmer_PAS_chr1-4_0165_0039" /evalue="3.90E-17" /label="PAS_chr1-4_0165" /locus_tag="PAS_chr1-4_0165" /protein_end="110" /protein_start="11" /score="62.6" /tool="antismash" /translation="YDLDISSLLCDDSVNLGVRYNFKPDSIDMDYPLELVQESSNYILK AESDPNVRKEPLVFEGTLGKTNQHDYLLIYDDITKRFQMDRFNGVLRMNKSRAP" ORIGIN 1 tttggtcata cgatcgacac caatcattcc agatatgaaa attgccttct tcaagtgcac 61 tgtctgcgat catacgatgg aggtcgaaaa tgatagaggt gtcattcaag agcccacaaa 121 atgtccccga gaagtttgtg cgcaagcaaa ctcaatgcaa ttgatccaca accgatcaac 181 atttgccgat aagcaagtta ttaagttgca agaaacacct gatttggtac cagatggaca 241 aactcctcac tccgtgtctc tatgcgtata cgatgagctg gttgatactg tgagagctgg 301 tgatagagta gaagtgtgtg gtatattccg ttccgttcca gtacgtacca acgctatcca 361 aagaacagtg aaggctcttt tcaaaacata tttggatgtt gttcatataa agaaggttga 421 cagaaaacgg atggcagctg atatatcgac tttggagaat gaagtctctg agcaacagga 481 agtggaagaa gtgaagaagc tttcggagga agatatcgaa atgattcatc aaatctctga 541 acgacctgac ttatacgaag ttctgtctcg ctctttggct ccatctatct acgaaatgga 601 tgatgtcaag aagggaattc ttcttcaact ctttggagga acaaataaag agttcgaaaa 661 gggaggaagg taccgtggag atatcaatgt acttttagtg ggagacccct ctacttccaa 721 gtctcaaatg cttcaatatg ttcacaagat agcaccgaga ggaatttaca cttcaggaaa 781 agggtcttct gctgttggtc tgaccgccta tatcaccagg gatgtagaca ctagacagtt 841 tgttctggaa tctggtgctc tggtgctttc ggatggtggt atctgttgca ttgatgagtt 901 cgataaaatg tccgattcta caaggtcggt cttgcacgaa gtaatggaac aacaaacaat 961 atcaattgcc aaagcaggta ttatcactac gctgaatgca agaacatcaa ttctagcctc 1021 tgccaatcct gtcaattccc gctttgatgt aaatttgcca gtggttcaga atatcgacct 1081 tcctcctcct cttctgtcca ggttcgattt ggtctactta attttggaca aagtggacga 1141 aaaagctgat cgcctactag cacaacatat gacacaaatg tacttggaag acactcccga 1201 gaatgtctcg gaatatgaga ttctcccaat tcatattctg acatcctaca tccaatatgc 1261 caaagaaaac ttcacgccag tgatgacgga ggagggaaaa gtggagcttg tacgtgctta 1321 tgttgaaatg cgaatgttag gagacgatcc cagatcatca gagaagagga taacagccac 1381 taccagacaa ttagagtcaa tgatcagact tagtgaggcc cacgccaaga tgcgtctttc 1441 agaaacggtt gatttgcaag atgttcggga gtccgttaga ttgatgaaag cagctatcaa 1501 gaactatgcc accgatccta agacgggcaa gattgacatg actatggtga tggctggacc 1561 gacaccggtg gagacgtaga tcgcattgtt acataagcat ggtgtggagt atattatagt 1621 tgtcctcgat cccgaccctc ggcaacatct cggatctcat ctgcctttgt tcctttgagg 1681 ttgattctgt aagtagcttt aaccacagtt cactatactg agtatggatt ccaagccatt 1741 gtctggggtg tcactagcgg aagctagtaa cttgaatctg gatccatctg tacagctgag 1801 gtccaatagc tctatacaag aaaactatcc ggatccagct aatgtataca cggagcaact 1861 aggtcattcc ccatcagaga gggacacact tctcccgcag agccctaatt acaatgctac 1921 gagtccttcc caaggtgctg gccgatcacc tttgtcgaag aagaaaagaa cgcgttcact 1981 actttctacg gacaagttga agtccttaaa cacgaaacta ggaaagtgga ccagagggct 2041 ttcatacaaa tggtggatag tacggtcaaa ggatgtagaa gggcagccta gtgagatcct 2101 tttcagtgtt ttcatggcac caccttatgt gcagcctctt agaagacttc cagcgggagg 2161 gttgatgaat atgggtccaa cttcaagaga agattttgca catatagtag atgacgttat 2221 cgatgccata gaacagggga taaaaccaac tagaatttca caaggctctt caggatcata 2281 ttttatgtac aatacgcagg ggaagatagt gggagtgttt aaaccaaagg acgaggaacc 2341 gtatggaccc ttgagcccta aatggaccaa atggattcat cgaaacttat ttccttgctt 2401 ttttggacga agttgtctaa tccctaattt gggatatatt gcagaatctg cagcgagtct 2461 tttggatcgc cagttgcagt cttttattgt tccctacaca gacacagtgc tactctcgtc 2521 cagtagtttc tactacgcat tttgggacag gtgtactcac gcttggtcta agaagccgta 2581 tcgcaagaag gtgggttcat ttcagttata tttaaacgga tacataggag cagatgagtt 2641 cttcaaaaag tatcccttgc cagctgacaa aggaaggagc ctattgccat ttttacccga 2701 taaacacaag aagaaaaaaa cttccaaaaa gagacaaaga ggtgatacta gacattctat 2761 ttttgacaaa gacactgttt ttgagtggaa tagggatacc ttacaacaat tacgagaaca 2821 gctggaaaaa ctggtaattc tggattacat catacgtaat acagacagag cttttgacaa 2881 ttggatgatc aaggtcgaat gggatgaata cttagatgaa gaggcgaacg aggcttataa 2941 gaggccgaac ttgaaagtta gagcaataga ctccgggctg gcattccctt ggaagcatcc 3001 taatgagtgg agatccttcc cttttggttg gttgtatctt ccaacatcag tgattgcaag 3061 gcctttctca gagagaacca gaaggcatta ccttcctctt ttgacttcca aagagtggtg 3121 ggaagaaact tcagtgctat tccgagaaat gttttcgaga gatacagagt ttaaggagag 3181 aatgtggaga cgtcaatggg ccgtactaaa gggacaagct ttcaatgtgg ttgaaaccct 3241 taaaattcca ggtcagagcc cattagatct tgttcaaaaa accagaataa tggtctggga 3301 taatgtcgtg gagatcccag tttcctacgt tcctagagac attgatatat ataatgactc 3361 tcctgtttgg acataccaaa attatgatga agagtactgg agctccaaca ttgctcacaa 3421 ctcaccagga aggtatcatg aacacgaacc aaccacacca gagtctgagt gtttggatga 3481 tcccttttct tcggctgcgt ccactgatcg tggaggttac gcaattagtt caaatgcaaa 3541 tactcctgga cgggccaaca ctgattccat tcaaaagccg accacggcta caagaagact 3601 catcgtggag aggttagaaa ctatcacttc caaaccacct gttttcacct ggtgttaaga 3661 tgtagagatg aggtcctcgc tatcttattg ttttttcaag gccgtttttc tcttgcaatc 3721 agtcatagat tattgcaagt tgtcaaagct ttgaagcggt atggtaaccc ctgctaacaa 3781 gattatatcc attcagtcac atgttgcgca tgggtatgtt ggcaacaaag ttgctggttt 3841 tgtactacaa tgccagtatt gggatgtgga cttgttgaac actgtcaact tttccaatca 3901 taccggctat ggaagcttca aaggccaagc aacaaccggc gaacaagttc tatctcttta 3961 tgaaggcctg caggatatca atgtccaata cgacgcgatg ttaacaggtt acattcaagg 4021 agcagatgga gtcgaggcga tgggcaaggt gtgcttggat ctgaaagaac gaaccccagg 4081 tatactatgg ttacttgacc cggtgatggg agacgaagga gagctatatg tgagcgcgga 4141 tgtgattccc gcttatagac gcatcttggg ctacaaaaaa gtcgacatta taacgcctaa 4201 ccaatacgag gctgaactac ttgttggttt tagcattaac aacactgatg atttgaggaa 4261 agccttaaag gtctttcacg aggattttaa tgttatgcat gtggtcatct ccaccttttc 4321 gttcactaag aataaggatt ttttctactg tgtcagttcc accaaaacct cttacaagaa 4381 gcctaatttt ttcaagatac catacatgga cagttatttc acgggagtag gagatctttt 4441 ttctgctctt ctggttgaca agatatatag actgcccggt ggagaaccca tagagcctgc 4501 agtgagcaac gctttgacaa tcatggagaa agtgttggac gttactcgac ggctgtgcgt 4561 agataaactt ggcgttgccg tacaaggaaa gatcggagat gccgagacca tgaaggagtg 4621 cgaacttaga atcgtagagt gccggcaatt ctacacgatg aaagatagaa atttcaactg 4681 tgagacaaag attttaactg attcacaagc atagagtcaa aatagcataa tattcaatac 4741 agacatccaa cgtcgacatt cttttctttt ttttttcctg taagacttct ctaggtcagt 4801 ggtgctccgc gtagcatgca ttttccataa ggaactggtt cgtgttttca cgcacacgag 4861 gcaaaattaa cttcttatct gtgacacata caaaggtcaa aaataaaaaa ttaatccacg 4921 tagaactgca ttgtgacagc attcgtttct gcatttgaac ctccatcgtg cgtgactaag 4981 caaaggcgac gcctacgtct ctagtcttcc taccaagccc tttcacccaa tcgtaagttc 5041 caccaaaatg taaatgacta aacctcacgt gatcatatct atctagcata tcatgctaac 5101 aaaagtctgc agactgcaga cgtaaatatt ttcctttccc atcattattc cctgtcaatt 5161 aacagccaaa ggacaatgaa cccattggat gtgataggtt cagacgggaa taaccatgtg 5221 tccaagcaac tgcctttaaa aacggcgtcg tcctgcttta acagttcctt ttcttcgttg 5281 accaagcaat tcactccaga gcttttgaaa tcggacaatg agagcgttga aagtctagcc 5341 aactatccat tactgacaga caatccttcg ttggtacacc aatggaatca tgagtattct 5401 gttgtctgtg tgagcgttag ttcttcccgt ggattactgt tctgtggcac tcaagacgca 5461 aagattcttg tgtttgatct gaacacatat gaaaagattc acgttttaca ggctcatgaa 5521 ggtgccgttt tgtgtttaga aatatcagca aatgagaagt ttcttttctc gggaggaagt 5581 gactctcttc tgagaatttg ggacttggaa accatgactg aacggttcac tatttattca 5641 ttaatggaca ttggcgacat ctttagcata acttggatcc aagacttgaa catggttttt 5701 tttggaactc aaaatgcttg tatattgtac gcttatgtcg aggtagacgg ttcctggaag 5761 aacgacccaa gttttctgcc ggcaaacaga tatgacaact tttttgattc gaaaggtcca 5821 ggcggaaaca tgaaccccaa acaaagtaaa aagaacaaac agcacacttc tccattggtc 5881 gaggtcgaca cgtataatat tttacgatat gcgcacaatg gttacgtgta tgctatgcaa 5941 tcctttaaga gaactccaga aactgtggag atatttatta acattcccaa tatttataat 6001 catatcctag tctcaggtgg aggggatggt ctcgtgaaac tgtggggtgt tggttcagat 6061 agatccgtag tggcgttgca tgaacttgat aacgaggatt ctgttctcag catggtcatc 6121 tcagggtcgt ttctttatgc tggattagta gacggacaag taaacctttg ggatttggga 6181 acttttcagc taatcaggtc caccaagacg gatgaagggg atgttctttc cttagcactt 6241 tacgccgatt gccttttcaa gggaactgaa catggtatca cgaaatggaa actgcaagga 6301 gctagaagaa cagattgggt gactcatgaa ggatatgctc ttactgtgaa actttttgaa 6361 aggcaaggaa atccctatct tatcacaggc ggagttaata accgccttgc gttgtggtct 6421 ttggatgggg tttattctgc atctaaaaga cgatcacttt cattatctaa aaagtcaatt 6481 ctaccattgg acaacgactc tttattacaa acactagcca aatttgtgtc ctataaaact 6541 gtttcgaagc ttcctcaatt ttttattgac gattcccgaa gatgtgcctc ctttttggtt 6601 aatctactga ccagctttgg ggctactgct cagctaattc ccgtgaagaa cggtaatcct 6661 atcattcatg catgcttccc agcacaagta attaattctg ctaaaaagaa accaagccga 6721 attctctggt atggtcatta tgatgtggta agtgcggatc aatccaacgg ttgggttcaa 6781 gatcccttta agatgtctgc catggatggg tatttatatg gaagaggtgt aaccgataat 6841 aagggtccac ttttagctgc aatttattct gttgcagagc tcttttccca agatgcatta 6901 aagtcagatg ttgttttcct tattgaaggt gaggaagaat cagcctcttt tggtttccag 6961 gaagccgttg gagcttataa ggacgttgtt ggagagattg attggatctt ccttagtaat 7021 tcttattgga ttgacgatca ccttccctgt ataaactatg ggttgcgtgg agttgttggt 7081 gtcaaagttg aaatatctag tgataaacct gacaggcatt ctggggttga tggaggagtg 7141 tctagggaac cggccgttga tctcgtaaaa ctgatttcta aattaacatc tgatgaagga 7201 aggatacttt tgccagggtt ttttgatggc ttgaatccac cctctgaaga agaggaaaaa 7261 gactatgaac gaattttgga gagagcaaag ataaaatcta gtaaagaaat gttgatggcc 7321 aaatggagat atccctcatt aactgtgcat aaggtgacag tttccggtcc aggaaacaat 7381 acgatcattc cacaaatggc atcagcagct atatcattac gcataacacc agaacaaaat 7441 ctagaatcgg ttaaaaacat gcttgtatcc ttcttaaagg ataagtttaa ggatttgaag 7501 acagagaatg aatgcaagat ttctataacc catgaagcag agccatggtt aggagatcga 7561 agaaatactg gttttcaagt actggaaaat gccattatca acgaatgggg cattgaacca 7621 ttgtatatca gagaaggagg atctattcct tccattaggt tccttgaaaa ggcctttggt 7681 gccccagcaa tacattatcc ctgtggtcaa gcttccgaca atgcccactt agataacgag 7741 agactgagag ttcggaatct ttacaaatct agaaatatct tgaacagggt tttccaaacg 7801 ttgtaattta tttgtgtgag tcaataattg ataaaaatac aaagagtaaa taaataagag 7861 ctataaaggt ggtgtagcaa atagtagtaa aataattgct tcaacttagc caaatcgtct 7921 tctttaacac catcagcaat cttggatctc caatcctttc ccctttcaaa tccgtttgag 7981 gctgtttgat agtccatgaa ggctttgtag atgaggtctt tagaagtctc cacgaatggg 8041 ccgtgttgaa caataggctg gtctaaaatc tgtcccgcaa cgagaacaaa ctcagcagga 8101 gaagtagcat cttctgggac ggagccggta atcttgtttc cattcaagtc aaagaacaga 8161 gcattgaact tatcatatgt tttgttgttg atttcaagac taccgtcaag taaatagatg 8221 aaggagttgt agttctcacc aacgctttgt tcaaatgatc ccccgggttg gacagtatag 8281 tagtaatagt caacaggaga atacgacaaa tcttggaagt tttcgacccc ataggccttt 8341 cctgagataa tcttaactgt gactttatca tttggagtta ctgtcgggat ctctgaggcc 8401 cttaaatctc ggtactcagg ttcactatgt ttaagatgct ttggtaggtc aacccacagc 8461 tgcattccaa ctatgttttc tcctgatttg ccttgaactg gcatttcggc gtgcataata 8521 cctcttccgg ctctcatgat ctgacaatcc ccggcattca agatcccaac cttgtcgcta 8581 gtgaaatcct ggtgggcgaa ttgacctttc gtcatatacg taatggtctc ttgcccacga 8641 tgaggatgat cagggaaccc agcacttggg tcaacgttga aatgatctag cagtaagaac 8701 ggtttgaaat ttctcatttg catggagcca attgacctac ggactttggc acccacacct 8761 tctgagactt cattgcaata gaaacttttt aaaactgaac gagacatgtt tgatgatgaa 8821 agacaagttg aggggtattt ataccttttc cttgcttagt taaccttact aaggagttct 8881 tacataggac tcgctaccag aagggctcat cagaatcatg catatcgaac cttcgcgaat 8941 attccatatt actaacaatt actaccttct agctatagtc gaggtggaga agcactgcgc 9001 ataataggct gcataatact tttacggagt aagctgactc agcatttgac atctcagggt 9061 ctatttgtca gttatttaag tttacgccat tattgtagaa gacttcaaat actatttttt 9121 tccaaaaaag ctcaataggg tggattgggc cttcttagat gatttgccct tgacggtccc 9181 aactgtgggt gaaggcttcg aactggacga tttggggttc gatgatttgt ctgtgcttat 9241 ctttgtattt ttaactgtcg taataaagcc gtcttcatca acataactag tgatcgcctc 9301 ctttgactgc tccacttcat tttgtgaggg ctcattactg gccaccgggg ggttaacttc 9361 ctgaatggaa gtgtcaaagt cagaggcaag gtcaacatcc atctgatcca cgggattcgc 9421 atcctctctt gcatgcgctt ggtcaccacc ttcatcctcg tcatcgtcaa ttacaaacaa 9481 actatcttca tttttgggcg gggcagactc ctcttgaata acctgtgtgt cttgcatctc 9541 gtcatcacta tcagtgaaca tggcagccaa ttcttgcctc tctttgttga tctcttcggt 9601 ggtctttttc cttggaggct cgttcaacgg gaaggaatta tcatcttcta tgtctccagc 9661 cacaatcgat tcttttggtt cttttctaga aacgtatgaa attttagatt tggagtttgg 9721 cttagctttt gaagtcggaa tggtcttttg tactgaggca gaggatttgc tgttttgggg 9781 tttcctagat acgtatttgg acgtaatgga tgggatagtt tctgttttct tgggaggttt 9841 tggactttgg ctctttggat ccggagagtg ttttggagcc ggttgtttta ccacgtccac 9901 ctttggccat tgttcctcta catgctcaat ttgttcagca ggttgttctt tgtgaaatgg 9961 actttcaata atgcctagct ttctttgcaa ttctgcattt aaccactcgt ttcgcctcat 10021 tccttccata ttggcaactt cctgggcacc aacgccacta gttgacaatg aatagcaagc 10081 cacagaaaga accttctcgt atccctgctt cacagtctcc agatcctgtt taccgaccaa 10141 cttaatatct aggccattct tgatgcctga tactgcgtaa atgatttcca gtttctcatc 10201 tttcttataa aactcagcta gttcttcctt tgagcggcgg acatcaatgg aaagctctct 10261 actgagcatt ctataggtca cgggcaactt ttcttcatag agttttgtcg ccagataact 10321 cgctatttgc gtcatttggt gaaagttctg ttgagaggaa gaagcgcgtt ctttttttgt 10381 aagagctcgt acgaaagact ggggttaacg cgttcctgat tcaactcaat tttcagaacc 10441 cagctgtgaa catacggtgc aaatctacga aagctacttg gtaaatcatc tatgtaccag 10501 ttttgcggta agtaattcgt gtttagctat tggaggccaa tcagctggct gagccatcac 10561 tctttgaaga agattctttg gacggacgat gctttcttct tcgcgcacct ttgcaagttg 10621 gtccatgtag tccaccagct aaggcctttc taacatgctt tctcttttat aagtagattc 10681 tttgacacag aaacaattac agacaagtca ttctgaccgg ttattgccaa atagccgacc 10741 gttattttct tctccatctc gtcaatgcta ctcttctcgc gttcattggc aaagctaagg 10801 tcgttcgcca accataatca acaaatcctt caagcaaaaa aatcttcacc aaaccatctg 10861 atactacatc atggcacagc taacaccagc agagattgag gtcgcaaaga agttcgactt 10921 gacctccaag ataattccct tcttggaccg tcatctgatt tacccactca ttgaaaactt 10981 ggacctcaca tacgatgaaa agaccatcaa agaactctca tacaatcttc tcagggatac 11041 ctacatgaac aagttcatca acgacttgaa cccagacaag gagatttctc aagatgtctt 11101 gacgaagcaa aaggaaattg aagccaaatc tgaagttttg gaagccgaaa caaaggaaac 11161 attgaacttg ttgagtaaga aagaagtgca agaacaattg aaatctgaca agaatcacaa 11221 tagaagatat ttggagtctc agcatggcat cactgaggat aagattcatg ccttgtatga 11281 atatggacag attcagtaca acaaaggtga ctacgttatg gcaagcgatt tgttggccaa 11341 ctttcgtatt ctgtctacaa acaacgagct aaacgttagc agcacatggg gtcgtttggc 11401 ttgcgaaatt ttgttattgg aatggaataa tgcgttagaa gagctgtcaa agctgaggga 11461 gcttatcgat tcaagaacct cttttaacga tccactctta cagttataca acagaacctg 11521 ggttatccac tggtctctgt tcccttattt caagactgcc aatggattag agactctgtg 11581 cgatcttttt ttcagttcgt cttacctgtc caccatccaa gcttcctgtc catgggtgtt 11641 gagatacttg gttgttgctg tcatttctaa caacagcaag aaattgaaag atctggttag 11701 agtcactgct caagaaagct accagtacgc ggatcctttt actaatttga ttaaagcatt 11761 atacttggac tttgattttg cccaggccag tcagcacttg aacgactgtg aagtgatttt 11821 gaagacagac ttcttcctga acaacgaaga cgagaacctt cctcttattt ccaaaaaatt 11881 cattaccaac gcaaagaaat taatcataca ggtctatgtg aaatgctacg gaaggatcag 11941 tttggaagca ttgtccgaga ctttgaattt gaccaagcaa gagctgaagg accttatcgc 12001 ttctttggac ttgaagaatg ctacacttga cgatgaaaag ttgatcatta atcacacgtc 12061 gaccaagatt tatcaacagg ttagcgataa agttaagtca ttgggctaca aatccaacca 12121 gctacttgaa aactttgcta aatagaattg tattcactat gtacatttat gtctgaagga 12181 aaagttaaga aaaaggctac tatcactcat tattaagagc ttgtagaaac agtagcgttg 12241 ttacgtttaa ccggtcttgg aacaatcttg tatggatgat ctctcttctt gaaagtgttt 12301 atgtcattcc tcattctagg taggttctcc aaactcttgg ggtccgagta aaactccttc 12361 ttacaaattt caacaatttc acggaatttt tcctcaccgt tttctctgtt atgtagcaac 12421 ttgtcaacgt tcttttgagt caaaggatta attgcgatat tctgtagctc caatctggcc 12481 actatcttgg cagtgtacca caatttcatc tccctttgag tgttgtccac tagttccatt 12541 ataacctggg gagccttgtc gttcattctt ggttctaggt ttagtattct ggtgtagcca 12601 ccagctctac tttggtatct tggtttgaga acattataca actttggaat tgtgacatta 12661 ggttcaaata tatcagccaa aatgagcgac ttgtcgtagt tcttcttggc cttcgtgatc 12721 aagttttcca ccagcgcttg agttttttta gcacgtgcct tggtcgtaat gatggactca 12781 ttttttatta aggatgaggc caaattccgc agcattgccc attcatgttt gactgatcgt 12841 cctaaaccca tgttggtgaa aagaaaaatg tgtagacaaa aaagttgtgc tggggtcgag 12901 aagagtctag gaggagaaga aaaaaaaagt cggaagcaac ttgggaggga ggagcaaaga 12961 catttgacct gctagggggt tacggctctc cttccacctc tggtgaactt cgcgacctcc 13021 aataaaaaca caacgtcttg agtttcacct cactccatac aacagaattg acatgggtgg 13081 aagaatatac gggttcctgg ccggtgctct gtttacctcg tcccttacat atcttgcacg 13141 agaacaattc cagtctgacc aagttcggat ttcaacaagg ctgcgctcct atcaaaaact 13201 cataaacgaa ggtgaccaac tgaaactcac ggacaataaa ctagaatacc agacaagacc 13261 atggaaagag gcattcaaag acttgtggaa cgaggaggtc attaaaacag tcaacagaat 13321 ttacagcatt agatggtacg aggatgctaa gtatctggtg gataaagttg agggtaaata 13381 gatcaattaa gttttcgaca ctacttatct ttttgttctc tctcgggaga tggcgatgat 13441 gatgacgatg gggatattct gctttgtttc ttgaagtagt ctcgtatttg tttgttaacg 13501 aacatagagg caattggtgc aaaaatgctg aaaaggaatg aaattatcac ctggataacg 13561 ccatagtacc tggggctgcc ccctaaagat gcactcatca gcacataccc tatgaaatct 13621 gtagtcacgt actgataccc actttgcaag gcgttgtaga ttattttgca acattgttct 13681 gtggagattg gtgacgatgg gccctcgatg atcctagtga tttctggttt tgatttctct 13741 tcctccagga acccctcact taaagtattt cctggaaata tgcattcaac tttgatattg 13801 tgtatcgaca cttcttgacg tagtatgtca ctcaatgatc gcaatgctgc cttcattggg 13861 gcatactgac cgtatccaat gaacgaatag aatgccagta cagatgaaaa aaacaccaag 13921 tgccttttgt agggcttttc tacctttgtc attaccttga gcgcaacatg tgagaagtac 13981 aacgctgtct tgtaattgat atcgattcca ctgctcagag tcttttcatc aagctctaag 14041 aaaagtccgg ggatggagga gccagcgcaa cagaaaacta tgtcgggact aaaaccaact 14101 tcctctaaaa cacgctcaca ctggtcatat ttggagatat ctgctgccac gtaagaaatt 14161 gtgttgccct tctcggtccc gtgaatatca atagcgtcct ttactacctg ctttagtaag 14221 gattctgttc tagccacaat cacaacggaa catccttttc catacaaaag tttagcaaac 14281 tcggctccaa caccctggga tgcacccgta ataattgcct ttttgttggt gacatcaaaa 14341 ttatcaaaca ttccagttcc ctctacactt tgtatgagaa tgatagctga aattgtgcac 14401 cagatgttag aagataaggt cgtgtcatga actaatatca tgaattccga gggtggctca 14461 acaactattc acgtgacttg gacgttggaa gttgaggtgg ttggtggatg ttgcacggag 14521 tatcatttgt aagcatgaaa tcagtctaaa aaacttgcag aatagcagag cggttcggaa 14581 attcattcaa aaccacctcc tcagattgga tctgccctac tctgtttagc tctgggagat 14641 tttctcggtc gtgttctttc gctggtctac ccacgctata ggaatcgctg tgaacgctac 14701 cttcttccca acttctcggt gactattata agccattccc actttgtttt caagcaccaa 14761 caacccaccc ccaccttatc tactccatct tgggtgtccc cgcgcctgtt gcaaagtccg 14821 aaccatagaa cccccgacct ttgtcccact aaccctcaga cacccctcgg aagtcaggga 14881 gaaaccactc cgaagtacat taatcatccc tcgtattctc gacggtgccc attttcttta 14941 taaaaaggga gacacaggtt gcttcactaa ctctagactt gtattctaca tccactctac 15001 acaatgtctg atctcttagc tatcaacact atccgtctat tggctgtcga caccgtggcc 15061 aaggctaact ccggtcaccc aggtgctcca atgggtctgg ccccagctgc tcacactttg 15121 ttcaagcaaa tgcgtttcaa cccaagaaac ccagcatgga tcaatcgtga tcgtttcgtc 15181 ttgtccaacg gacatgcttg tgctttgttg tacaccatgc tatttttgta tggatatgac 15241 tacaccattg atgacctgaa gagcttcaga cagctcaact ccaagactcc aggtcatcct 15301 gaggctgaac taccaggtgt cgaagtcacc actggtcccc tgggtcaagg tattgccaat 15361 gccgttggtt tggcaattgc tcaagctcag ttggctgcca catacaacaa gccaaactac 15421 gaattgttca gcaactacac ttacgctttc ctaggtgatg gatgtttgca ggagggtgtt 15481 gctcaagaag ccatttctct tgccggccat ctcggagacg gtttaaagct aattgctttc 15541 tgggatgaca atcaaatctc cattgatggt gataccaacg tctctttcac tgaagacgta 15601 cctgctaagt ttagagccca aggttgggaa gttctgagcg tcaaggacgg caacgatgac 15661 ctcgaaggta ttgctgctgc tttggccaag gcaaagacca ccaacaagcc aactttgatc 15721 agattaccaa ccatcattgg ttacggctct cttcaacaag gtactcacgg tgtgcacggt 15781 tctccactga agcctgatga catcaagcaa ttgaagaaga agttcggatt tgatccagaa 15841 caaaactttg ttgttcctag agaagttact gaatcttacg ccaaacatgt tgccgacaac 15901 cagcaagttg aggtcgaatg gaacaaactg ttaacagctt acactaagga gtatccagaa 15961 ttgggtcagg agttgcacag aagattggat ggcaaacttc cagaaaactg gcagaaggct 16021 ttgccaacat acacggttga tgacaagcct gttgcctcaa gaaagctgtc cgaaatagtt 16081 ttgaccagca tcgagaagga attgccagaa ttggttggtg gttctgccga tttgactggt 16141 tctaacttga ccagatggcc agacgctgtt gacttccagc caaaatccac aggattaggt 16201 gacttttctg gaagatactt cagatttggt gtcagagagc atggtatggg agccatcatt 16261 aacggtatct ccgcttatgg tgccaacttc aaagcttacg gtggtacttt cctgaacttc 16321 gtgtcctacg cctccggagc cgttagattg tccgctttgt ctggacaccc aattatttgg 16381 gtcgctacac atgactcgat tggtctgggt gaggatggtc caactcatca gcctatcgag 16441 actctggccc acttgagagc tcttccaaac ctcatggtgt ggagaccagc cgatgggaat 16501 gaaacttctg ctgcctactt gagggctatt gagtctaagc acactccttc catcattgct 16561 ttgactagac agaacttgcc tcaactagaa cactctagca tcgagaaggc tgccaaaggt 16621 ggttacactg tctacccagt cgagaaccct gatatcattc tggttgcctc tggatctgaa 16681 gtttctattg ctattgacgg tgccaagaag ttaggaaccg aaggtgtcaa agcttcggtt 16741 gtttccattc cagacttctt cactttcgac tctcaggcta gatcttacca attatcagtc 16801 cttccagacg gtgttccaat aatgtctgtc gaggtcatgt ctaccttcgg atggtccaag 16861 tactctcacg agcaatttgg tatcaacaga tttggtattt ctggaccagg ccctgagatt 16921 tacaagttct ttgagttcac tgctgagggg gttgctgaca gggcttctaa agtcgtccaa 16981 ttctacaagg gaaaggaact tctatcgcca cttaataagg cttttgagtc tgttcatgcg 17041 tagtttgtgc gcctttaggt agttagttaa ttagtaagtt catagtgcgg gaagaatagg 17101 ctgtcttaga atgctcgaca aagttaccag gattgcgagg attatttatt ggagtgaata 17161 cttgtaattt attttgcttc cttcttactc tcctcttcct tcgactcatt atttgccacc 17221 ctcaaagatg gccccgatat ccgttgcgtt tgtatgtcta ggaaacattt gccgaagccc 17281 catggctgag gcggtgttca cccacttagt caaagaaaaa ggactcgact ctaagttcaa 17341 aaagattgac tcctttggaa cttcaggata ccatatcgac gatactcctg atcaccgttc 17401 cgtggcgtgt tgcaagaaac atggagttcc tgtgaaccat agaggtcagc agatctcgcc 17461 ggacgacttc taccactttg actacatact ggccatggat gaatcaaatc tctccaatct 17521 caaacgcata cagcccaaag actccaatgc cgtagtcagg ctctttggag actacagaac 17581 ggacaagtcc ttccacagga ttgtggagga tccttactac ggcgggtctt ctggatttga 17641 gagaaatttc aaacagatta cgcatttcag tgaagaattc ttaaacaaag agttatagat 17701 tatagattat caacttttca aagatacaac gtttccaact tgtccttctc aaaagtaaaa 17761 tcgtcttttc tcctgggaag ccatgtctcc tggtaatcaa agtatttcca gttgctcttt 17821 tgttgaacgt gctcttcaat aggcggagga gtttgattag cttcgtcatt attgagcagg 17881 aaccaggtct tgagctcttt gtggtacttc cagccccttc tatgcaactc cttcgccgta 17941 ttaatttgta ggaaactgcc tgagttgtcg aataccttat gttcatcagc tgcattctcg 18001 tagctgtgat aatagaaaca gtagaataaa gtctccaaat caaagttctg taaaatcttt 18061 gccgagttca taatctccaa caaaggttcc tgagggaacg aaatatgggt agggtgtggt 18121 tgtctaggga tatacatgtt tggcacatct gcatcaaatg agtctggaca atttaacagt 18181 gaagaattaa gcagttgata catgttgtcc atctcttcag gggtcttttt aatcggctta 18241 ttgagacatt ccttcttgac tccatccaaa ttagcaataa gattgtttgc aattttcaag 18301 gacgattcag atgttggagc gtcaagacca ttgggatgag tagtcgttga cgacaaagaa 18361 tccaatggta gagaagaaga ggaaactgcc ggatgtgcag ttgcggctgt agttgcagtc 18421 ggagtggttg aatgggtgga cgatccaacc ttcgttgatc ctggtggcac acttgcggta 18481 gctgctgtac tggcaacctt agaatatttc aacttgggcg tcagcacagg ggccacagca 18541 ggcttaagat ttgattgaat tccagttaat tcgttatgag aatgtggggg agtcgcagca 18601 gctgatcttg caggagatgt tcttgtgagt ttgttgagca aaacagatgc attggagttc 18661 gttgaggtga cattggagac agatcctgtt gatgagttaa tagcagcagg agcggtcttg 18721 acggtgctgt cagaagttga accttgattt accgcagcaa aattactaga tgcactggca 18781 cttggagact cgttatctga tacattttcg tcattttcat ctttaccttc ttcatctttt 18841 gaaaggggtc cagaggcggc ggcaaacaag aacccatctt caatttcatc cagtcccaat 18901 tcatcataaa taccatcatc ttcagcaaaa tcggcatcct ggttagattc gacgtaatac 18961 tcaatatcct cttgtatgcg ctggatttga tccgcctcca aattaccatt ctgaagcaat 19021 cttagtatag tttgaagttt ctcctgatgc cagttatttc tatccaagga ggactgtagt 19081 tcggcaattt gatcggtctt agagttatcc agtttcttcc ctcgtttgcc actactctgg 19141 atttgatcta tctgagcttc caaggcttca ctctgtcttt ccaactcttc aatcatggac 19201 tccacaaact tggaggtctc tgacttttcc ttttcccttg gatcgacttt attcatgttc 19261 agtccctcct tactgaacgc ctttgtcttc atttctttct cgacctcttt gaatcgctcc 19321 atctcatgtt caatcaattt tctgtgttcc atcaatcctt tcttctcctt gacttcattt 19381 cccgccaacc atattttgat ttggtctctg gatcgttgta gttttttgat ttctcttttc 19441 agatcacttt ctaatttttc cttctgagaa gagctctcgc atgcttgtag tttatcatag 19501 acataatcga actcttccag accttctttg acttttttga acacacggtc aatctctcta 19561 aacgggggac atatgttagt gtctgatttc ttttccttgc gacttgacta gaaaacaaag 19621 catctttgtc acttagccat taatggtaca cgataactta ctgttgtaac ttcctttgag 19681 acatgtgtgt ggtggttaag aactgtcttc tatactatgt tgtcgttgtg ttctcatgat 19741 gatgtcacgt gaacgggttt tctcccaatg tcggttcatt attggcagag cacacgacta 19801 ttgggtttct tcatatcgaa ccccatcgct tccccaactt taggccatgc actactggtt 19861 atcttttacc gacaactgaa ttatttttca gactcaactg agtcatttac agtgaggtta 19921 ggactcattc aaacgaaacc caacttgtct tcatattttt tttcacttag acggattccc 19981 cgcactctta agaacgaacc atgagtgaag agaacctaaa ttactgggcc aatatcctag 20041 acggcccaac actaagtgtt cttcctcgag attataaccg gcctgtagcc ggcaaagtga 20101 tagaagccaa caagacattt gacatttcag acattcttcc cttcttgaac aaagccaacg 20161 agccatctgt cacccagttt actgctccac tggctgtgtt tgccgtcttg gtctacagac 20221 ttaccggtga tgatgacatt gtcatcttga ccgattcacc aaagaaacaa aatctcccct 20281 ttgtcgtcag acttcaagtt gatccttcca agtcatttgt cgatgtttcc aagcaagtag 20341 gcgaacaata tcttgagagc ttggagcgtg caaccccgct gaaagatatt gtaacccatc 20401 ttaaagagtc caaacaattg ccaaattatc cccccatttt caggctaagt ttccaaacag 20461 ccaagaaggt tcaacaactg tcaactctgg tcgagggatc tacgagagac ctggctattt 20521 ttttggagaa taataccagt atcaatattt actacaactc tcttttgtac acccacaatc 20581 gtattgcata tttcagccaa cagttttctt ccttcattga cgaagttaac aaagctcctg 20641 aaactccaat aggtaagatc tctctactaa ctgagcagca gtctaaactg ctccctgatc 20701 ccactgcaaa ccttgattgg tcaggatata gaggtgctat ccaagacatc ttctctgata 20761 acgcggagaa atttcccgac agaacatgtg ttgttgaaac taagtcattt ttgaacccca 20821 attcccaaac tagaactttc acatacaagc aaatcgacca agcttccaac attgttggaa 20881 actacttggt gcatacaggt atcaaacgtg gagacgtagt catgatttat gcctaccgtg 20941 gcgttgatct gatggttgcc gttatgggag tacttaaagc tggtgccacg ttttctgtta 21001 ttgatcccgc ttatcctccg gccagacaga acgtctatct gcaagttgct aaacctgctg 21061 gtctaattgt cttggaaaaa gctggcgttt tggatcagct ggttgaggat tatatcaaga 21121 acgagctaag cttggtttct cgtatatcaa atttgaaaat tgaagccgat ggtaacgttc 21181 tgggtggaga cgtggatgga aaggacgctt tatacgacta ccaacaattc aaaactagaa 21241 gaactggcgt tttggttggg cctgactcta atcctacatt atcgtttacc tctggatctg 21301 agggcatccc taaaggtgtt cttggtcgtc atttctcctt ggcctattat tttccttgga 21361 tgtcaaaaac tttcaacctt tcagagaatg acaagttcac aatgttgtct ggtatcgctc 21421 atgaccccat tcaaagagat atgtttactc ctttattttt aggtgctcag cttttgattc 21481 ctactagtga tgacattggt actccaggaa aattggcaga atggatgcaa acctatggtg 21541 caacagtgac ccatttgact cctgctatgg gacagctgtt gtctgcccag gcaactaagg 21601 aaattccttc ccttcatcac gccttttttg ttggtgatat ccttaccaag agagattgtt 21661 tgagactgca aactattgct caaaacgtga acatcataaa catgtacgga accacagaaa 21721 cgcaacgtgc agtttcgtac tttgagatac cttcaagagc ccaagattcc actttcttgg 21781 aagttcagaa ggatatcatg ccggccggta aggggatgca taatgttcag ttacttgtag 21841 tcaacagaca cgatagatct aagacttgcg caataggtga agttggtgag atctacgtcc 21901 gtgctgctgg tttagctgag cagtatagag ggcagcctga ccttaacaaa gaaaagtttg 21961 tccccaactg gtttgtatct ccatctaagt gggtagaaga agataagaaa atctcaaagg 22021 acgaaccttg gagggaattc tacttaggac ccagggatag actctataga actggggact 22081 taggaaggta tctacctacc ggagattgtg aggtcagtgg tagagctgat gaccaggtta 22141 agataagagg attcagaatt gaattggggg agattgacac ccatatctct aggcatcctt 22201 taattcgtca gaacgttact cttgttcgta gggacaaaga tgaggagcca attcttatct 22261 cttatgttgt gcccaaagaa acacccgaac tggaaaactt caagtcgtca tctgacgatc 22321 tggacgattt gaatgatcca attgttaaga gtttattatt gtacagagaa ttgataaaag 22381 acctaaaagc acatttgaag aaaactttgg cctcttatgc tatccccacc attattgtcc 22441 caatggcaaa gttgcctctg aatcctaatg gtaaggttga caaaccgaag ttaccctttc 22501 cagatactgt ccagcttgct gctgtagccc aaaagtcctc tgctgaggtt gatgactctg 22561 aatttaccac cacagaacta cagatcaagg atctctggtt gcaagtactt cccaatccac 22621 ctgccagtat ttcgttagaa gactcatttt tcgatcttgg aggacactca attttggcta 22681 cgagaatgat tttcgaactc aggagaaaac ttgcagtcga tttgccattg ggtaccatct 22741 tcaagcaccc cactgttaag cttttcgcag cagaggttga tcgtgtcaag aatggtgacg 22801 aagttcagtt tgcggacaac aagcaggaga gtacttctgc tggatctgac gaacaagttg 22861 ttgactactt tcaagatgca aaggacttgg tttcaagtca attgctagac tcctataaat 22921 ctagattggc tctttcaaat gctgagctga tcaacatttt cttaactggt gctactggat 22981 ttttgggctc ttacattctg aaagatctct tggagagaga cttggatgtc caggtctatg 23041 cccacgttag agctaaagac gaagagtctg ggcttgaaag attgcgcaac accggtaagg 23101 tttacggaat ttggaatgaa gaatggacta gccgtattaa ggttgtcatt gctgatctca 23161 gtaaagataa gttaggtcta tcaggtgaaa agtatgctga gctagctaac actattgact 23221 tgatcataca caacggtgct ctggttcact gggtctatcc atattccaag ttacgtgatg 23281 ctaatgtcat ttctacaatc aatgtgttga acttggcagc ttctggtaaa cccaaacagt 23341 ttggatttgt ttcatctact tcaactttag acactgaaca ctatatcact ctttcagaca 23401 cgttaacaga acaaggtgag gatggtattc cagaatctga tgatttgctt ggatcttcca 23461 agggtcttgg aactggatat ggacaatcta agtgggcagc tgaatacata attcgccgtg 23521 ccttcgagag aggtttaaga ggtgccatta ttcgtccagg gtatgttacg ggccactcta 23581 ggactggtgc ttgtaacaca gatgacttct tgttacgtat gttgaaagga tgtgccgaac 23641 ttggaaagtt acccaacatt tctaacacgg ttaacatggt cccagttgat cacgttgctt 23701 tagttgttac tgcatcttct cttcacccta ctgcagaaga aggtcattgt gtggtacagg 23761 tgacagggca tccaagaatc cgcttcaacg agtttttgaa cgctttgaat gactatggtt 23821 atgaagtaaa gttaactgat tatgttgagt ggaaacgtga cttggaaaga tttgttgtgg 23881 atcaatccaa ggacagtgca ttgtatccat tgctccattt cgtgttggac aatcttccac 23941 aagacactaa agctccggaa ctagatgaca aaaatgcaaa agatattctt agcggagaca 24001 ccagatggac aggatacgat ggttccaagg gtagaggggt agattctgcc caaacaggta 24061 tctacattgc ctacttaata aagacaggtt tccttccccc tccgtctaag gaaggcaaga 24121 aaccgttacc agaaattgag atttccgaag aatccttgaa attgattaag gaaggcgccg 24181 gagctcgtac cagtgctgcc tagttctata tgtaagtgat attaaactca gttcataaac 24241 aaaaattgta ggtctgaagg tgtcaatctg ctgatagcag catcatcttg gttaatggtc 24301 gcatgaatca tatttgcctt tttatcttgc aactcgatga ttctggactc aatgctatct 24361 tctatacaaa atctggtaat cttcacaggc ctatgttggc caattcgatg aacacggtca 24421 ccagattgcc attcaaccga aggattccac caagggtcaa gaatgaatac ttgtgaagct 24481 tcacataagt taagtgccac acctccagct ttcaaagaca ccaaaaacac ctctacggac 24541 ggagtttcca taaagtgctt gatagtactt tctctttgga gaggagacat tgaaccttgc 24601 aatttaacag tttcaaaccc tgctcttttc aaacgccatt ctaccaggtc caacatactg 24661 gtaaattgag agaaaacaat cgatttgata gtgacacggt cacttctaag atgaaacaac 24721 tcctccacca aggcttcaat cttggttgaa gacctccatt cacctcccat tctaatacga 24781 ttcacaatgc ttcccttttt aataagttcg aggtccactt ctattgctgg accttctaag 24841 tctatgctta atgccaagtg acatactggg cactccagtt tgtttgggtc tccgttgaaa 24901 ccttccacat attcggaaac acacaagcga cagaatttgt ggtgacattt actttcaata 24961 ggctcttcag cctcatcatc acacaattgg catacaatga ctccttctgg cataccagaa 25021 ctatcgatgc tgttggtacc aactcttctg agtaccagat caggatggtc tgcaagttga 25081 cgcatccgag taatcagtgt aaagatgttg gcatagttgt tcagaacaac cccctccgca 25141 acatagtcat tgaactttct cttactgtcg gaatacaagc ttgcatacaa gtccttttcc 25201 tcctcattga atctatcacg gcggatctcg acaattctgg gaggaagacc caagtcgtca 25261 gcccgctgaa ctttggttct tctcagcatt atatttttca ataataatct gatattcttg 25321 aagctctcca acccgaggcc ttctaccccg tacttctgaa tatttttcaa catgaaatgg 25381 ttgaaaaaat tggtgtgtaa catgggagta tgtccacatg tgtcacaaca tttccaatta 25441 gtgaatttcc actccgtgga tcggcaatca cacttagtgc agaaatactc acagaatggg 25501 tacagtttca taaaacgaat tagagaatac atttctccaa ttctattctg tagcggagta 25561 cctgacaagc accatctctt ctctgtgtct agagaatttg cagctttggc tgtcccgctt 25621 tgtctgtcct taatattgtg ggcttcgtct aaaatgaccc tataaaaatg cgtattgtgc 25681 aaaggactgg gttctttcac cagtccacgt tttcgtttga atccatagtt ttgcttccta 25741 taaaccgatt caagaaccga ataagttgtc agtatcacat catattcctt taactcttcg 25801 gcactctttc ctctattttg accatgaaag accccgacct tcagtatccc attggtatga 25861 agttctatct cacttttcca ctgcattagt gccaccgtgg gtgcaataac cagattgggg 25921 gacttagttc tgtcatgcat aaacaacgca atagtctgga tggtcttccc cattcccatc 25981 tcatctgcca gtacaccccc accaaactcg ctctcctcct gcttgacgag ccagttaaga 26041 ccttcaagtt gaaacggcaa gagagtacaa gtcattcctt cgggctgagt ggcttttttc 26101 acttcgattt gttcgtgctg gtctaaattc ggaaagacat ctttcaaaga aggatgaatg 26161 ttgtagagtt tttcagttac tctagtgaaa taaggtactc ttggtttctt cggttttgct 26221 ggtgtcttcc gtttcttttt gggtctagga gcctcagcct cctcaactac ttccaggtcg 26281 agttcctcta attcctctgg tatatcaata ttctgttcca aatcgctcag atcactgaga 26341 tctgaaagac taattgcgtt aacaatactg gcaccattag gtctgtttct gccggtgcta 26401 gtccctctaa taacaatagc atcttcttct tcatcgtctt cgggtttaat atcgtcaacc 26461 ttgtctgttc caagcgactc ctggtactcc tcatcttcag attcgtcctt taccttcctc 26521 ttcctagaag atttagagga tgaggtaccg tttggaggaa gctcatcgtc cgtctcaacg 26581 taggagacag ctttcttcgc agctcttctt ctcctggcgg gtttcttgta gtctgggtcg 26641 tccactatga atccgcctgc ttcgcttgct ttggtcatca gtggcaaggt tcttcttaac 26701 ggctatctgc gaaagtagaa agagcaatat tggggtatcc aaatccggtt ttcctaatga 26761 ttaggtctct ctcgtaaatg gctccacttc gtaaaaactg cgtctgttaa caacaatttt 26821 cagggatgac tgtagcctgc cgcaacaaaa aaagttgtta ggaactctgg atcatctcag 26881 gcaaatatca aggtctagag acgcacctcg tgaaaattta cgcgaaagta gtagaaagtg 26941 tatagcataa ttgctaaacg cgattacaaa ttgctcagat gaaaaaaata attctataac 27001 ataaatgtaa taatgaacta taatccataa tgcttactta aggcgataaa tggtctgttg 27061 caaaaagttc ttccgcgtag tcaaagtccc ataacgagtt ctgcaacttg ttctctagtt 27121 tagctttctt actgggttcc tcgtcggcgt cggatgatct cttcaaaact tcattttctt 27181 caggaggggt aggcaacatt ccaaacgata gcgtcttgct gattgccgaa acatctctga 27241 acactgcatt gattgcagct ggcgtaacct tgctagacca ctcgttggca tttttactgg 27301 tagacggaga gtccaagggt cgggacgagc ctggggtctt gataaaagat agtggagtct 27361 gcaagattgc ggacggagtt ataccctttt gagatatagt atctttcttg acagaattgc 27421 tttccttgga gtctagtagt tgagtctcct catctttgag gtccaacgag cgagataaca 27481 tgcagaggaa ataagaagca gggtcatcaa gtcccaattc ttttattctc atccgagaag 27541 tattaatagc ggcactctct gcttcttcct ttgcttggat ctcgttctgt tctttcgtag 27601 ctacaagatt ctctggtgac tgaacgctgc taggagttgc catcactaca gggcttgatt 27661 tagccgcagc gttggtagca gccatcctat taccttgcac tttggcttgt ttaccgggtg 27721 cgccagtaga aggtcccgat acggatgatt tgacttttct tttagcttgc tgaacttgct 27781 gtataggtac ctgttgttgt agctgctgac gttgctgtgg ttgttgcagc atctgctgcg 27841 gtacttgctg ttctaatgaa gcttgatagg gttgttgtga atgttgtggt tggggcatat 27901 tattaggcag ttgttgcata tactgctgag gtttagcatt gggggaagtt tgaacttgct 27961 gagccaaccg ttgctgagga agagcgcgtt gctgttgccg atgctgctgt tgttggggtg 28021 gaaactgctg gatttggtta ggcatcaagg agttttgatt gagcataggt gtctgcatca 28081 agggagacga gtttaattgc tgtcccgaag ctggggtgac tctctgttgc tgactgaatg 28141 cagcagtatt gttcagagaa gggtcttgaa tccctaaacc tgaaaacatg ttgttagcat 28201 ttgatccacc catgagcgag tcaggatttg tctgcgacgt gtagagcata ttatttggca 28261 gctgcttatt tccctggccc atctggggga cttgctggag attagaagtc tgctgctgtt 28321 gttgctgttg ttgttgcaga gactgaacat tttgtaattg ttgaaacttg cgctgctgga 28381 gttctttcaa gtaagtaatg tacttgtgaa tctgagtttg aactctttgt aaaatgtttg 28441 gagtcgccaa atactcattt cgcttcagac tttctaaaac ttccttcagc atgaacttga 28501 tttgaatcag ccttcttgta ccctcaacat tctttgtggc aataaaaaag ttcggaatca 28561 aattctctgt tgtgatagag agctggatca tagtcttagc ctgatccagc acagctcgtt 28621 tctgatcagg tgtgatttcg tttgtcacat tttttagctt tattggtagt tgcaaagcct 28681 ctgcgtacac ttttcttaaa ttagtccaat cctcttctgt agcttggata ccaggtaaaa 28741 gctttatagg ttgcttttgc tgctgctgat gcatattagg cacaggttgt tgtgcatttg 28801 gaagtgcacc gaacatagaa tttgatggta cagattgttg aggttgtttc tgttgctgag 28861 gtttttgcat aggccttgca ttgttgaatg ttgtaggcaa agtttggttc atcaggggag 28921 acgtattgac aaatttctgt gcctgttgta gtggcacaga ttgaccagga aagcctggaa 28981 ccgcttgagg aaccgagttt tgattgttcg cttgttggct tgaaggattt gcagtagcat 29041 ttttgttttg tagaactcgt ggtaggtaat gtcgttgaat gaacgttttg atgaaagatt 29101 gttgctgggc cggcgccaat gtttggggca agtcgccagt ttgtttcagc ctctcaatca 29161 aattcaatgc ttgcgtagta ccttccctaa gcatttcttg tgttatttga agttgtggct 29221 gctgagtagc agattgttgt ggtggctgct gtggttgttg ctgctgctga ccttgaacca 29281 atttggaatt gaattgagga ttctgagctt gttgttgaat gtgctgttgg ttgttagcca 29341 tacgattctg ttgcataaac atctgatctc tttgtggctg gggttgtgtt tggggttggg 29401 tctgtacctg gggttgctgg ggtggtttct gcatggcatc ttgatgactt cttgcttgta 29461 acagttgcga gtggaccgtg taaacctgtt taatggtgtt catcagctga ggatttattt 29521 gcccattctg caacatctgg gttatttgag cccaggtatt gacgccaact ggaagcccag 29581 gaatacgttt caaaagagcc tcaggtattg gggcagtttt aagattgact ctttggtcat 29641 tggagaaatt attcatcatg ggacgctgcg gttgctgttg ttgctgttgt tgttgcggtt 29701 gctgttgctg attatttttc atatactggt tttgctgttg atgttgctgc atttgtggtt 29761 gaacgggaat attctgttga cccatgctct gcattccgtt cagagtagct gcagggtcag 29821 gggcattagc ggccatggag gaacgaccgt taaccgcagc ctgcttgatg ctggatactt 29881 tgtttctcaa catgtcaacg tactccttct ttgatctagc attgctgaac gcccattttt 29941 caaagtcttc agccaactgt ttggtcttag cgttattaaa ggaattattg ccctgtattt 30001 ggaagactga ctgtacaata atgtttatga agccctgtcg ttccttcggg ttgagttccg 30061 agtgccatgg ctgttgtggt aacccgttca tggcaagaca aagggcgatt tgggaatggt 30121 ggggatgatg gggaaggaaa taaagagagg gaatgaggag agggaatctg agcgatttga 30181 gactgaacta atgcggatga tgatgcgatt cgagacaaga acgaggggga tagattagac 30241 aaaatatcat gatatattta catgcaaaat cattgggggt agtgaacctt gcagatctga 30301 ggtaattgtg gtccacagtc tggaaggcga tctgaaagga gcgtattgta tcatagcgga 30361 tatagtacga cctgcttctg acgtattgtc aacgagctgc accaggggcc taagattata 30421 aatcaggatc tcaaaggggg agcatgtagt gaaagccaca cggagaaatg gagtcagaaa 30481 cctacttaaa gagagtttgt gagtgaagaa tgaatttgtt gcagattata tcgtgtacgt 30541 gggatccaca gctcagctga gttgaccggt tagagcttca ctgagcaggg ttgtttgcta 30601 ggatgccaaa ttgggaattt ttcaaatgca agctggatga cagagaatta gtaacagccc 30661 aatccgcctt ttcttttttg tctttggatt ctcttgttgt catgatatgc gactgtacgc 30721 tctttactaa aggaagatgt tcagactcac gcatcgattg gcgactagct ggcgactagc 30781 tggcgactag ctggcgacta gctggcgact agctggcgat gagtgatact cactcgccct 30841 tggtgcttat cgccccatac aaaaatgact cttgcgtagg aagttttggt aggggcgcca 30901 ggtttagtcc cacttggtcg tgtcaatcac ccgctggatt taccagacgt tccttttgct 30961 ttcttctcca atcaacagat ccctcttcaa ggcagttggc atccttctcc tcaagatggg 31021 tgcttgggta atggatgttt ttcatgacca cacctcactt gacttcttgg ataatttact 31081 aaagtcacaa gatcaggtta aatttgttgt ggattcgttg gctgctccgg taccacaaac 31141 tcttgaggat ggcgagattg attgcagtga atcctttcaa aagttgatgt ctgccatttt 31201 tcttgcaatt tggctggact tcgatacaaa gattccctta gccaaagcga agtactctgg 31261 ccacatcact gatggtatcg aagaaaccta tgacaaagtt aaggattccc cagatttcca 31321 ggaactcgaa aagcagggac aatttttcaa aaatcaagcg aaacaatggc ttaaatcttt 31381 atctgaaaac cctgaattat cggagctctg tgaattatgg ataaaggatc cagaaaacta 31441 caaaaagtgg aaggaaaaca tagattgggt aattgacttt gtctcctgaa gaaaaagggt 31501 ctacttgtgt cagtcgtatc attttattct ggtgccttta gagcttgaac tcctcctagg 31561 atcagatact ttaggatacc gtttatctct gtctttgtaa ttgctctata gcttctttta 31621 tcaacaaaga aagatctccg cctgcatctc caccgctttc tatagcacat aaattatttt 31681 gcaacgtctc gagagtaggt aacattgaca gttctgtagt ctctttaaag atcacgataa 31741 cattatccaa cacacctcca aagtaagcgc agacctgaac aaaaatctcc ttcttttccg 31801 cattcgatga ggagttattt gatgtcagtg ttgacgccaa tggagacact ctggagattg 31861 tttccttaat ttcggtttgc gtccacttga ggtcattttg caccatcgta tcatccttca 31921 ccgcatcttg ctgaagagtt ttggaaatgt aatcatccaa gagcctcgcc aaaactaaca 31981 atccatggaa attacgtagt tgagagttct cctggtccat acttggtagt caaccaattg 32041 cttacagaaa atgctcccaa ttaagtaaaa ttgagagttg aaaaatacaa ttccaaattc 32101 gtttcacgga atttttccaa acatcaaata attcgaattt attcacttaa ataatacgcc 32161 tattttatac atatgaatag atcaaatctt tccggcttcc atttcaatat ccagcagctc 32221 cagggacgtt ttccttcccc ttcaaagata acaaaatctc cttaaatcta gtcttgtccg 32281 cttcatcagc accaaaagaa ctgttcttct tcaacttcag cagctctact gttctatccc 32341 acacacttcc ctggtcgaag aaactgtccc tcttggcaat gaacttctcc tcgtcctcct 32401 tggtggcctt tagagatttc tccttcttgt cgttatagtt gacataaaag tcatccacat 32461 ccttctcagc ctgttttttg atctcttcgt gtttcttggc agcaacctca tctctcttgg 32521 agatctccaa ttcagtacgc tctttccact cttgaattgg cttgctctcc ttcaagtcca 32581 aattatcaaa agtgctgtgc agtggagtat gtgcctcttc ttcgggagca tcttctactg 32641 gaatactctc ctcttgatca gcatctactt tgggaaagtt gctctcaaat tcgtcgaact 32701 cgtccacgtt gtcgtcagcc aactcttggt ctctctcggt tgtgaattca tcgcccaaaa 32761 gttccttttc tctacttaaa aagtcacctt gcgaaggaga ttcaccggaa gatgcgccgg 32821 tgtcgacgtc tttcaactct ggaaacttgt cagccattgt gaagaaatta tgcggcaagg 32881 taaacagggg aggtagtgag agaagacgat ctggaggttt gggggcccca cctaccaatg 32941 aaggtttcga gggtcctaac tcccgttgga cttccctcta gtttgccatt cctccccttc 33001 gaggctgaac gctctcgtat ttctccacca acaaccaaac cattgatact tactccagac 33061 catgtcttac tcaaaggata tagttttgga aaagcttgct agtttggaag aaacccaaat 33121 tagcattcaa tccatcggac aatggtgtct atttcaccat agacatgctc ccgaaaccgt 33181 cgccatttgg agtgaatttg taggttccac ccaaaccaag aagcttgcgg ggctctatct 33241 ggccaatgaa attattcagc aatcgagagc taaacgaaag actacatttc tagatgagtt 33301 tgccaaggtg ctaccatcta ctttagagca aatctatccg agtatgatct ctactcacca 33361 ggcgaaactg aagcgaatta tagatgtctg gagtcaacgt aagatatttg actcaaacct 33421 gattcataga ctttatcaga gcatacagga tcaaaaagct tataacggtt tatcctcgtc 33481 tagttcaaat tctccaccaa tcaattctgg ggatttggct cctgagattt cctctctatc 33541 aacgctgttc aacaaaatct caacattgaa gtcttcaacg tctctggtcg ttaatcagat 33601 aaatgaacaa tactcaagtc tattcgactc tgaaacatta ccaggaactg atatttattt 33661 aaaacaactt ggagatctat caaccttaat cacctcagcc agatcaaagt cacaggagac 33721 ccaagaatta cgagagtcca taataaatga gctgaagaaa ctgattcaag tccaagagtc 33781 gtggattacg aaagatgcag agtcttcggg ttctctggat gagaaacttg ccacagttca 33841 gcagaaagaa tcagagttga aagaattcat aaacgatgta gaagaagaag atggtgtacc 33901 tcaatatgcc gcttcaagtg atgaagaagg cgacgaaaat gtgtcaaaaa agagaaaaat 33961 ggagagccca ccaactgaaa cagttgattc tggcgaacag ccaactaacc cagtccaccc 34021 tcagctttcc tccatcttag agagtctatc tagaacaact ggactaacac cagaacctgc 34081 ttctacttcg gacgagtcag caacagcaac gcagaagcaa gatgaaacac ctgtttcttc 34141 atctataaat cctgctctag ccagtttgct gtccaaactt aacggttaat tcttaatgtc 34201 ttccccaatc acttgagtac gaactatgta ttatataatc aggcatcttt tctttttttc 34261 tttttttttt gtctctcgct tggatcccaa caccatattt cagatctcct gatgactgac 34321 tcactgataa taaaaatacg gcttcagaat ttctcaagac tacactcact gtccgacttc 34381 aagtatgaca tttcccttgc tacctgcata cgcaagtgtt gcagagtttg ataattcctt 34441 gagtttggta ggaaaagccg tgtttcccta tgctgctgac cagctgcaca acctgatcaa 34501 gttcactcaa tcgactgagc ttcaagttaa tgtgcaagtt gagtcatccg ttacagagga 34561 ccaatttgag gagctgatcg acaacttgct caagttgtac aataatggta tcaatgaagt 34621 gattttggac ctagatttgg cagaaagagt tgtccaaagg atcccaggcg ctagggttat 34681 ctataggacc ctggttgata aagttgcatc cttgcccgct aatgctagta tcgctgtgcc 34741 tttttcttct ccactgggcg atttgaaaag tttcactaat ggcggtagta gaactgttta 34801 tgctttttct gagaccgcaa agttggtaga tgtgacttcc actgttgctt ctggtataat 34861 ccccattatt gatgctcggc aattgactac tgaatacgaa ctttctgaag atgtcaaaaa 34921 gttccctgtc agtgaaattt tgttggcgtc tttgactact gaccgccccg atggtctatt 34981 cactactttg gtggctgact cttctaatta ctcgttgggc ctggtgtact cgtccaaaaa 35041 gtctattccg gaggctataa ggacacaaac tggagtctac caatctcgtc gtcacggttt 35101 gtggtataaa ggtgctacat ctggagcaac tcaaaagttg ctgggtatcg aattggattg 35161 tgatggagac tgcttgaaat ttgtggttga acaaacaggt gttggtttct gtcacttgga 35221 acgcacttcc tgttttggcc aatcaaaggg tcttagagcc atggaagcca ccttgtggga 35281 tcgtaagagc aatgctccag aaggttctta taccaaacgg ttatttgacg acgaagtttt 35341 gttgaacgct aaaattaggg aggaagctga tgaacttgca gaagctaaat ccaaggaaga 35401 tatagcctgg gaatgtgctg acttatttta ttttgcatta gttagatgtg ccaagtacgg 35461 tgtgacgttg gacgaggtgg agagaaacct ggatatgaag tccctaaagg tcactagaag 35521 gaaaggagat gccaagccag gatacaccaa ggaacaacct aaagaagaat ccaaacctaa 35581 agaagtccct tctgaaggtc gtattgaatt gtgcaaaatt gacgtttcta aggcctcctc 35641 acaagaaatt gaagatgccc ttcgtcgtcc tatccagaaa acggaacaga ttatggaatt 35701 agtcaaacca attgtcgaca atgttcgtca aaatggtgac aaagcccttt tagaactaac 35761 tgccaagttt gatggagtcg ctttgaagac acctgtgtta gaagctcctt tcccagagga 35821 acttatgcaa ttgccagata acgttaagag agccattgat ctctctatag ataacgtcag 35881 gaaattccat gaagctcaac taacggagac gttgcaagtt gagacttgcc ctggtgtagt 35941 ctgctctcgt tttgcaagac ctattgagaa agttggcctc tatattcctg gtggaaccgc 36001 aattctgcct tccacttccc tgatgctggg tgttcctgcc aaagttgctg gtcgcaaaga 36061 aattgttttt gcatctccac ctaagaagga tggtaccctt accccagaag tcatctacgt 36121 tgcccacaag gttggtgcta agtgtatcgt gctagcagga ggcgcccagg cagtagctgc 36181 tatggcttac ggaacagaaa ctgttcctaa gtgtgacaaa atatttggtc caggaaacca 36241 gttcgttact gctgccaaga tgatggttca aaatgacaca tcagccctgt gtagtattga 36301 catgcctgct gggccttctg aagttctagt tattgctgat aaatacgctg atccagattt 36361 cgttgcctca gaccttctgt ctcaagctga acatggtatt gattcccagg tgattctgtt 36421 ggctgtcgat atgacagaca aggagcttgc cagaattgaa gatgctgttc acaaccaagc 36481 tgtgcagttg ccaagggttg aaattgtacg caagtgtatt gcacactcta caaccctatc 36541 ggttgcaacc tacgagcagg ctttggaaat gtccaatcag tacgctcctg aacacttgat 36601 cctgcaaatc gagaatgctt cttcttatgt tgatcaagta caacacgctg gatctgtgtt 36661 tgttggtgcc tactctccag agagttgtgg agattactcc tccggtacca accacacttt 36721 gccaacgtac ggatatgccc gtcaatacag cggagttaac actgcaacct tccagaagtt 36781 catcacttca caagacgtaa ctcctgaggg actgaaacat attggccaag cagtgatgga 36841 tctggctgct gttgaaggtc tagatgctca ccgcaatgct gttaaggttc gtatggagaa 36901 actgggactt atttaattat ttagagattt taacttacat ttagattcga tagatctaac 36961 cggcatctaa catccagtgt ttctaatcta gtgaatcgag atcaagtctc actctgaaca 37021 taataaataa ggtctaaccc catggaatta catgtcccct tgggttctga gattgtctta 37081 cccggtgggg aaagagccat actcaagttc gtaggaaatg tggagtcaaa gtctgggatt 37141 tttgctggtg ttgaactgat tggtcaaatg agtggaaaag gaaagaattc tggagagttt 37201 aagaacgtgc agtactttac caccaaagtc cctaattcag gcatattttt gccctatcaa 37261 agacttctgg agacaagtaa catgcaacga cttcaagcag agacaccaac gaagacaaaa 37321 cgaaatgttt atgtatctcg ctcaccatta gctgtttcca atcaacaagg gttgaaacga 37381 tcatcaaagg agagtagccc gagcactgtt gcaggcaatg aaggacaatt gcacagtttg 37441 aagactgaaa atacccatct ttcacagaaa tgtttgaagt tagaaacaca gttacaagag 37501 tgcacggaag ttctcgagtc tatggagaag gtcattaaag accattacga accagccttc 37561 aaccaaatgg agaaagattt gtctgagaag aatgaaaaaa tttccaagct aaaggtttca 37621 ttcgacgaac agaagaccga actgctggat attattgatt cccttgaaaa acaagcgtca 37681 gaaactgaac agctctacac taaagaattg aaaaggttga gggaggaatg tgctgcttat 37741 aaaaacaagg atactgcaaa ggaaacgaac gaactccaac gtcagctgaa agtcaaggaa 37801 aaaatgtgtc aagattggga gttgaaatat actcaactta aggattcaaa aagtaaagag 37861 gaaaacgata taattcaagg ataccagcgt gaaatcgatg atttgaaagc aaaattatca 37921 agctctcaga aagctcaacc tgaaaaaaac acggaaatag aagagcaatt acaacgattg 37981 aaagcagaaa atcgatctct gcaacaacag cttgagaccg ccagagagaa ggaaaaaata 38041 caaccattga cctcaacaac cacagagcaa tcaaccttgc tggatgagaa cgggaacttg 38101 caaatatttg ttccaaaaaa ctctgatccc gcaaatggaa gaaaaaaatg gtgtggtctt 38161 tgtgaaaggg aaggacatga tagcgttcaa tgcccttttg agaatgatat gttttaaagg 38221 ataatgattt tctcgttctt ttattagaaa agaagaacaa attcccaatg aattctccta 38281 atattatgca gattaaacta cctagcagct acaagactct tggttgttcg tagatggtcg 38341 gttcaaatcg atgttgcgac gtctcttggt agctgaattc agtttctctt caactggtaa 38401 cttggaggca atcgaatgga aaacatcctt tattccttcg cctgttttag cacttatttc 38461 cttgaaaatg agccccaatt catccgcgta ctccttggcc tccttggttg aaaccttacg 38521 ttcggcttcc aaatccagct tatttcccac caaggccacg acgatgtcag cgctagcctg 38581 tttctgtagt tcctgaatcc aggatttagc tctatccaag gaagattctt gtgttatgtc 38641 gtaagcaaca agtgcacagt tggcatttct atagtacatt ggggccaaag acttgtatct 38701 ctcctggcca gcggtatccc aaatctcaaa tttgattgtg gtcctttcat ctagctgaat 38761 agtttgggtt aaaaatgcgg ctcctattgt tgactctctc aaatcgtcaa aggagtcggt 38821 gacgaaacga tgtacgatag aggactttcc aacagcactt tccccttaaa gaatgttagt 38881 cagatggcaa accacgaata tggaacagcg acgtctaaag aaatacttac ccaataaaac 38941 aagcttgaac tgggcaaatc tgggctcttg tgtaactaaa tcagccatga tgacaggtta 39001 gatgtaaggt gtagatagtg gcagagtggg tttgcgataa aagccgtgtt gataggtgaa 39061 cgaccttgtt tcttttttat ttttctctca actgagacac tagaatcgag aacgaaaacc 39121 ttttcgcaga ggagatgagt tgagtaaggg tagggctgaa ttgattctga tattttgttt 39181 ctatttacat ggaatcaacc aataatttaa ttctcgatct tggcaagaat ctctctgtcg 39241 gagaacaaca gatactcttc atcgttgatc ttgactggag atccaccgaa cgagggaatc 39301 aacacattgt cgccggcttt gacgatagtt ggttccaatg atccattttg gtttggaaca 39361 cctggaccag tggcaatcac cgttgcctgg tgcaacttct ccacgttctt ctcgggaatg 39421 tagataccag aagcagtctt ggtggcggcc ttagctcttt gaacgagaac tctgttcagc 39481 aatggcttga gtgagttggc tgactttaaa agagtagact tgaactgtta gtaaccgttt 39541 gcctgctatt gaccaattgg gagtgacgac gacttaccat tgttgttaat gtgctgttaa 39601 tcgaaagatg gagagtgaaa gaaggaaaaa gggagagaat ccggtaccga ttttttatat 39661 tggaactttc gagaagttct ggaaatatcc tggggttgtc tggtagtgcc tatgctaata 39721 gggtccctaa tatgataata ctctatatct atgctacatc ttattcacat actagttgat 39781 ctgctgcgtg agagaagcta ttgactgttc taggaccttc ttttcaccga aaaccaaaat 39841 cgagatggcc agcttttgag aatctttggt taccctaatg gctttctcat agtcgttgct 39901 agtcagtccc ccatcttggt aggcggtaga tctttgcttg caccaattta gaatattctg 39961 atatgctgcc ttttcaggag attccagagt accgatcttt tccaggaaca gggttttatc 40021 gtctgcctct ctcagctctt gaaattcagc ctctgaaaga gacaatagtc ttgcgagagc 40081 ataagtagat tgggaaggcc ttccctccgc attgactctc aattcaactt gccatggtag 40141 atattctggt tgctcttcct cttcctcttc tccttcatcg ttaccaccat cacatgagtt 40201 acagcaggat cctggactgg cctgggagtc tccattgcat gattggcatt cggcgtcaga 40261 gtgatactga tcgtcacctt cctccccatt tttatggcct tccttttctt ctttgtcttc 40321 caccccttcg ttgtcgtact cctcttgatt taattgagct gtgtaatgca aataatcgtt 40381 gaacacttcg tatcccttgg aatcccacca gtctttacga tctgggaagt tcttgagctg 40441 gcttaaagcc tggtctccaa gactcacata atcattgggg ttgttgaggg acgtaaatcc 40501 atattttgtc aacagggacg tattgtttag atccccatag gtgttgagca attccttgtt 40561 ctttgggatt gacttgacaa tcttgatatc acagcaaaca tcgggtatca aaagactgtc 40621 ttcatcgata tcgctcatgt cactatcaga gttatcgtgc ccttcagctt cggaggcatc 40681 agattcctcg tcagacatgt cttcacgttc cagttctttt tccaacttgg taatatagtc 40741 ttccgtcacc tcaaatggtt cattattacc ttctttctta ttatcttcca ttccgtcctc 40801 ggtatccgcg tcatcgtgaa ctttgtcttc ctcgtcttcc tcgttatcac cctcttgctc 40861 caaatcgctt tctatctcac tgtcaggagc tccatgctct atatggccac actcgtcaca 40921 actggcacaa aatgggcaaa catctcccaa cgcttcgaaa tgtacatgct cccttccgta 40981 tgaatcatgg ttgaaaagat cggctcctgg aacaagggcc aattcatggt aattatcaac 41041 attgaacgac ctagaagcta ttgctaatgt tatagcagca aattccaaaa gtttttcttt 41101 ggcattgttt tcatcaacag ctaactcagt ggggactttg aggacagatt cgtattctct 41161 ggcaaacgat acgcaagact caaacagccc ttcagtctct tcttcaaaat tatccaagac 41221 tgaataaagc tcagttccta ttagcagatt tttcttctca tctggccata aatgaactgg 41281 aagtattaaa cccttagtat tcttaggttg aattgtttga agatatgcat accatggaga 41341 atcggagcct aaggacttct catacaaaaa cgccaagata agtcccaaat gactatcagc 41401 accacattca tggagcaaat tcgaaatgaa agagttcttg ccgcttaaaa tcgactgctt 41461 ggatactctc agaagaaggt tctcttcatc gtcctcttcg tcatgcccaa tcttttcttt 41521 agcaaagact cctactcctc caagaggaga ctctcttatg gcaaccaagt cttcattcca 41581 ataagccttg tttgacgggt ccctaaacca ttctatcagt tgttcagtca tgagtaaatg 41641 ttagacgtaa gatggtaaac gtgaaaaaaa aaattcatgc atagaacgtt cctgataaga 41701 acatccgaaa tccatcactt tacctacaac aaaatatact atcttttata taactacaaa 41761 actaaacttt aaagagttaa tctaccagtg gtaacacatt ggcttcgaag tatccctcgt 41821 tgacataatt tcctggtggt gagtagttgc ataccacgta ggctccgtaa tagtcattgc 41881 agtacttgaa agcgcagccg agctttgtgg tgcttttcca aactacttga gtgaaatgtc 41941 caacacctgg ggtataacct gggttattaa agtcataata ttcaatttca ctgtaccagg 42001 catcaacagt ccctctggtt gagtaaccat acgctaagtt ttctccgtac agactatttc 42061 cagagtgaac caaggttccg tcacaagtgt atgcgtcagc atatgcttgg gcggcagcat 42121 atacttcttc atcccactct aatccgtcaa ctccatgtag agctcttttt atgttgtgtt 42181 catcaagaat ttgatattta aaagcatcaa agtcggaact tgccgttgga cttatatcgt 42241 agggagtagt agtagaagaa cctgtctctg aggacgatgg ggttgggctt gttgactctt 42301 gtcctgtggt ttgtgtaatg gtggaagact ctgaactggt tatcgatgaa ctggttgcta 42361 gcgagctact accagttgat gattcagtgg cagatgtgga cccagatgtg gaccctgatg 42421 tctcacttga agattcggtg gtagcggaag tggcaacgct agattcaatt gtcgaactca 42481 cttctgagct gacagttgca cttccaccag ccagtgtgga agaagtctct tcactaacat 42541 ctcgagcata tactgtagta taccagactt cagtggtagt atgtgtgttg gtgtaacaac 42601 attcagcgtt ggccttggtc aatactgaga taattgatag caatgaaatg tgaagtaatc 42661 tcattatagt tcaaaggaat gtaaaaagtt ggagaactga aatctgatag tattgccctt 42721 caaaagtagg atatgtgttg tgctttctct tcagacaggt ttagaaatgt aatgtgatac 42781 aaatatgtta ctatgacccc cattatatat tcgctgcagg tactaagtta cttgaaatgg 42841 ttggtttcta attgaagata gccttttcaa acttaccata aagttgattc tgtaatgcgt 42901 atcaactatg taacagcatg tatgtcgcgc atagagaaca aggatggctg gtgaaatctg 42961 agtgagattt ctccatcggg aaatagtacc tgcactatta tcaaccgcat ataggtttag 43021 agacggtttt gttatgacga tttggaactt tgactaaacg ttgtagtggc gagttctttc 43081 atgctgatcg gccttgctac agagctagca ggggtattat gaaactctgg gttcacgtag 43141 gtggcctggt tctgaaattc cttggattta ggatcatcgt caacaaaaaa gttgatggaa 43201 ttggacgcag gtacctcttc gagatcagat tcccaatctg agtagttcgg ctgccaatta 43261 tcctcatgga aggagtcttt gcttagttcc atttgtgtag cactttgttg atcagtagac 43321 ttgtcagatt ttgatatccc aatgccgaca agcccggccc tctcttgagt tgggggagga 43381 gtttctattc ccatttctgc ttccagttct ccaacaaacg aggtcaggtc gtcgtcatcg 43441 tcgccattat cattattatc gttactatcg tcttgaaatt ctagtggtgt atttggtggt 43501 ctttttgaag caactttggg atgctcagct ttggacacta agatggacga aggcgtgtgc 43561 ggagtaaggt gcaccttcgg tatagaaacc tcttgcttct tcttatccac actttcggtt 43621 aaagaagagc tgtttttggg tttgctttcc ttcatatgta tatggaccct attttccaat 43681 ggttttgttg gtttcaactt tgtttcaagc ttgaaggggg ttacttttct taaagcggta 43741 tgattggcag tcgcaacata aggcctagag ccactagccg gagaatcctt tcccagtttc 43801 agcttttcaa acttcgtgag caatttgtca ggcgctctgg acttattcat ccgtagaacc 43861 ccgttgaaac gatccatctg gaagcgcttt gtgatatcat cgtaaatcaa taaataatca 43921 tgttgattag tctttccaag ggttccttca aaaactagag gctccttgcg aacattggga 43981 tctgactcgg ccttcagaat ataattggac gactcctgga ccaactccaa gggatagtcc 44041 atatcaattg aatcgggttt gaaattgtat ctaactccca agttgacaga atcgtcgcaa 44101 agcaaagacg aaatgtctaa atcgtactcc ccatccggaa tgtccaatac ttcactcatt 44161 tgccaacttc ggaataaatg tgcggcaaga gcagtgtgtg act //