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planemo upload for repository https://github.com/phac-nml/mykrobe-parser commit 97945a3ad655f1a0f99f577d0d423124460d900a
author nml
date Tue, 24 Oct 2023 21:28:06 +0000
parents 8e7e5a660942
children
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{
    "ERR3335753_L1": {
        "susceptibility": {
            "Ofloxacin": {
                "predict": "S"
            },
            "Moxifloxacin": {
                "predict": "S"
            },
            "Isoniazid": {
                "predict": "S"
            },
            "Kanamycin": {
                "predict": "S"
            },
            "Ethambutol": {
                "predict": "S"
            },
            "Streptomycin": {
                "predict": "S"
            },
            "Ciprofloxacin": {
                "predict": "S"
            },
            "Pyrazinamide": {
                "predict": "r",
                "called_by": {
                    "pncA_T389TG-A2288853CA": {
                        "variant": null,
                        "genotype": [
                            0,
                            1
                        ],
                        "genotype_likelihoods": [
                            -1707.2912821258215,
                            -685.0256738025864,
                            -10049.785656880731
                        ],
                        "info": {
                            "coverage": {
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                                    "percent_coverage": 100.0,
                                    "median_depth": 131,
                                    "min_non_zero_depth": 128,
                                    "kmer_count": 2768,
                                    "klen": 21
                                },
                                "alternate": {
                                    "percent_coverage": 100.0,
                                    "median_depth": 43,
                                    "min_non_zero_depth": 41,
                                    "kmer_count": 779,
                                    "klen": 19
                                }
                            },
                            "expected_depths": [
                                236.0
                            ],
                            "contamination_depths": [],
                            "filter": [],
                            "conf": 1022
                        },
                        "_cls": "Call.VariantCall"
                    },
                    "pncA_G390GG-C2288852CC": {
                        "variant": null,
                        "genotype": [
                            0,
                            1
                        ],
                        "genotype_likelihoods": [
                            -1736.2599622230955,
                            -680.8401734761619,
                            -9873.233821297094
                        ],
                        "info": {
                            "coverage": {
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                                    "percent_coverage": 100.0,
                                    "median_depth": 130,
                                    "min_non_zero_depth": 128,
                                    "kmer_count": 2719,
                                    "klen": 21
                                },
                                "alternate": {
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                                    "median_depth": 43,
                                    "min_non_zero_depth": 41,
                                    "kmer_count": 779,
                                    "klen": 19
                                }
                            },
                            "expected_depths": [
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                            ],
                            "contamination_depths": [],
                            "filter": [],
                            "conf": 1055
                        },
                        "_cls": "Call.VariantCall"
                    },
                    "pncA_G391GG-C2288851CC": {
                        "variant": null,
                        "genotype": [
                            0,
                            1
                        ],
                        "genotype_likelihoods": [
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                            -680.5372646726655,
                            -9858.860191248112
                        ],
                        "info": {
                            "coverage": {
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                                    "percent_coverage": 100.0,
                                    "median_depth": 130,
                                    "min_non_zero_depth": 128,
                                    "kmer_count": 2715,
                                    "klen": 21
                                },
                                "alternate": {
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                                    "median_depth": 43,
                                    "min_non_zero_depth": 41,
                                    "kmer_count": 779,
                                    "klen": 19
                                }
                            },
                            "expected_depths": [
                                236.0
                            ],
                            "contamination_depths": [],
                            "filter": [],
                            "conf": 1058
                        },
                        "_cls": "Call.VariantCall"
                    }
                }
            },
            "Rifampicin": {
                "predict": "R",
                "called_by": {
                    "rpoB_L430P-CTG761094CCG": {
                        "variant": null,
                        "genotype": [
                            1,
                            1
                        ],
                        "genotype_likelihoods": [
                            -14797.71027662235,
                            -2370.6712704022216,
                            -210.1929350878079
                        ],
                        "info": {
                            "coverage": {
                                "reference": {
                                    "percent_coverage": 100.0,
                                    "median_depth": 5,
                                    "min_non_zero_depth": 3,
                                    "kmer_count": 101,
                                    "klen": 21
                                },
                                "alternate": {
                                    "percent_coverage": 100.0,
                                    "median_depth": 190,
                                    "min_non_zero_depth": 188,
                                    "kmer_count": 3622,
                                    "klen": 20
                                }
                            },
                            "expected_depths": [
                                236.0
                            ],
                            "contamination_depths": [],
                            "filter": [],
                            "conf": 14588
                        },
                        "_cls": "Call.VariantCall"
                    }
                }
            },
            "Amikacin": {
                "predict": "S"
            },
            "Capreomycin": {
                "predict": "S"
            }
        },
        "phylogenetics": {
            "phylo_group": {
                "Mycobacterium_tuberculosis_complex": {
                    "percent_coverage": 99.69,
                    "median_depth": 236.0
                }
            },
            "sub_complex": {
                "Unknown": {
                    "percent_coverage": -1,
                    "median_depth": -1
                }
            },
            "species": {
                "Mycobacterium_tuberculosis": {
                    "percent_coverage": 98.335,
                    "median_depth": 220
                }
            },
            "lineage": {
                "lineage": [
                    "lineage1.1.2"
                ],
                "calls_summary": {
                    "lineage1.1.2": {
                        "good_nodes": 3,
                        "tree_depth": 3,
                        "genotypes": {
                            "lineage1": 1,
                            "lineage1.1": 1,
                            "lineage1.1.2": 1
                        }
                    }
                },
                "calls": {
                    "lineage1.1.2": {
                        "lineage1": {
                            "G615938A": {
                                "variant": "ref-G615938A?var_name=G615938A&num_alts=1&ref=NC_000962.3&enum=0&gene=NA&mut=G615938A",
                                "genotype": [
                                    1,
                                    1
                                ],
                                "genotype_likelihoods": [
                                    -21093.01908042143,
                                    -3131.7111098608775,
                                    -36.41722114142065
                                ],
                                "info": {
                                    "coverage": {
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                                            "percent_coverage": 100.0,
                                            "median_depth": 7,
                                            "min_non_zero_depth": 7,
                                            "kmer_count": 140,
                                            "klen": 21
                                        },
                                        "alternate": {
                                            "percent_coverage": 100.0,
                                            "median_depth": 266,
                                            "min_non_zero_depth": 253,
                                            "kmer_count": 5283,
                                            "klen": 21
                                        }
                                    },
                                    "expected_depths": [
                                        236.0
                                    ],
                                    "contamination_depths": [],
                                    "filter": [],
                                    "conf": 21057
                                },
                                "_cls": "Call.VariantCall"
                            }
                        },
                        "lineage1.1": {
                            "G4404247A": {
                                "variant": "ref-G4404247A?var_name=G4404247A&num_alts=2&ref=NC_000962.3&enum=0&gene=NA&mut=G4404247A",
                                "genotype": [
                                    1,
                                    1
                                ],
                                "genotype_likelihoods": [
                                    -18797.627911556006,
                                    -2876.301552830875,
                                    -17.415442468427592
                                ],
                                "info": {
                                    "coverage": {
                                        "reference": {
                                            "percent_coverage": 100.0,
                                            "median_depth": 3,
                                            "min_non_zero_depth": 3,
                                            "kmer_count": 89,
                                            "klen": 21
                                        },
                                        "alternate": {
                                            "percent_coverage": 100.0,
                                            "median_depth": 233,
                                            "min_non_zero_depth": 222,
                                            "kmer_count": 4676,
                                            "klen": 21
                                        }
                                    },
                                    "expected_depths": [
                                        236.0
                                    ],
                                    "contamination_depths": [],
                                    "filter": [],
                                    "conf": 18780
                                },
                                "_cls": "Call.VariantCall"
                            }
                        },
                        "lineage1.1.2": {
                            "G2622402A": {
                                "variant": "ref-G2622402A?var_name=G2622402A&num_alts=1&ref=NC_000962.3&enum=0&gene=NA&mut=G2622402A",
                                "genotype": [
                                    1,
                                    1
                                ],
                                "genotype_likelihoods": [
                                    -20293.11207308055,
                                    -3214.134387325289,
                                    -14.413062967015499
                                ],
                                "info": {
                                    "coverage": {
                                        "reference": {
                                            "percent_coverage": 100.0,
                                            "median_depth": 3,
                                            "min_non_zero_depth": 2,
                                            "kmer_count": 55,
                                            "klen": 21
                                        },
                                        "alternate": {
                                            "percent_coverage": 100.0,
                                            "median_depth": 247,
                                            "min_non_zero_depth": 241,
                                            "kmer_count": 5008,
                                            "klen": 21
                                        }
                                    },
                                    "expected_depths": [
                                        236.0
                                    ],
                                    "contamination_depths": [],
                                    "filter": [],
                                    "conf": 20279
                                },
                                "_cls": "Call.VariantCall"
                            }
                        }
                    }
                }
            }
        },
        "kmer": 21,
        "probe_sets": [
            "tb-species-170421.fasta.gz",
            "tb-hunt-probe-set-jan-03-2019.fasta.gz",
            "tb.lineage.20200930.probes.fa.gz"
        ],
        "files": [
            "ERR3335753_1.fastq",
            "ERR3335753_2.fastq"
        ],
        "version": {
            "mykrobe-predictor": "v0.10.0",
            "mykrobe-atlas": "v0.10.0"
        },
        "genotype_model": "kmer_count"
    }
}