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18
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1 hmmpfam - search one or more sequences against HMM database
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2 HMMER 2.3.2 (Oct 2003)
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3 Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
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4 Freely distributed under the GNU General Public License (GPL)
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5 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
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6 HMM file: myhmms
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7 Sequence file: 7LES_DROME
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8 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
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9
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10 Query sequence: 7LES_DROME
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11 Accession: P13368
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12 Description: SEVENLESS PROTEIN (EC 2.7.1.112).
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13
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14 Scores for sequence family classification (score includes all domains):
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15 Model Description Score E-value N
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16 -------- ----------- ----- ------- ---
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17 pkinase Protein kinase domain 314.6 6e-95 1
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18 fn3 Fibronectin type III domain 176.6 2e-53 6
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19 rrm -40.4 0.72 1
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20
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21 Parsed for domains:
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22 Model Domain seq-f seq-t hmm-f hmm-t score E-value
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23 -------- ------- ----- ----- ----- ----- ----- -------
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24 fn3 1/6 437 522 .. 1 84 [] 48.3 8.8e-15
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25 fn3 2/6 825 914 .. 1 84 [] 13.4 2.2e-06
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26 fn3 3/6 1292 1389 .. 1 84 [] 15.9 1.2e-06
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27 fn3 4/6 1799 1891 .. 1 84 [] 63.5 2.3e-19
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28 fn3 5/6 1899 1978 .. 1 84 [] 15.2 1.5e-06
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29 fn3 6/6 1993 2107 .. 1 84 [] 20.3 4.3e-07
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30 pkinase 1/1 2209 2483 .. 1 294 [] 314.6 6e-95
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31 rrm 1/1 2223 2284 .. 1 77 [] -40.4 0.72
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32
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33 Alignments of top-scoring domains:
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34 fn3: domain 1 of 6, from 437 to 522: score 48.3, E = 8.8e-15
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35 CS C CCCCEEEEEECCTTCCEEEEECCC CCCCCCCEEEEE.ECCCCCC
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36 *->P.saPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge
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37 P saP + +++ ++ l ++W p + ngpi+gY++++ +++ g+
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38 7LES_DROME 437 PiSAPVIEHLMGLDDSHLAVHWHPGRfTNGPIEGYRLRL-SSSEGNA 482
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39
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40 CS CCCCEEECCCCCECECCEEEEECCCCEEEEEECCC CCCC
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41 wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-*
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42 + e+ vp sy+++ L++gt+Y++ + +n +G+Gp
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43 7LES_DROME 483 TSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGeGPVA 522
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44
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45 fn3: domain 2 of 6, from 825 to 914: score 13.4, E = 2.2e-06
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46 CS CCCCCEEEEEECCTTCCEEEEECCC CCCCCCCEEEEE.EC
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47 *->PsaPtnltvtdvtstsltlsWsppt.......gngpitgYevtyRqp
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48 ++P l++ ++ + +sW+ p++++ ++ + + +Ye+++ +
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49 7LES_DROME 825 GGKPHSLKALL-GAQAAKISWKEPErnpyqsaDAARSWSYELEV-LD 869
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50
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51 CS CCCCCCCCCE EECCCCCECECCEEEEECCCCEEEEEECCC CCCC
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52 knggewnelt.vpgtttsytltgLkPgteYevrVqAvnggG..GpeS<-*
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53 + +++ ++++++ g+ + l+ L+P+ Y++rV+A+n +G++G+++
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54 7LES_DROME 870 VASQSAFSIRnIRGPI--FGLQRLQPDNLYQLRVRAINVDGepGEWT 914
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55
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56 fn3: domain 3 of 6, from 1292 to 1389: score 15.9, E = 1.2e-06
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57 CS CCCCCEEEE EEC CTTCCEEEEECCC CCCCCCCEEE
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58 *->PsaPtnltv......tdv..tstsltlsWsppt....gngpitgYev
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59 Ps+P++l+v ++ t++++ s++l+W++p+++++ Y +
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60 7LES_DROME 1292 PSQPRRLRVfverlaTALqeANVSAVLRWDAPEqgqeAPMQALEYHI 1338
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61
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62 CS EE.ECCCCCCCCCCEEECCCC CECECCEEEEECCCCEEEEEECCC
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63 tyRqpknggewneltvpgttt.sytltgLkPgteYevrVqAvnggG....
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64 ++ + g e +e +++ ++ ++ L+P+ +Y+++V A+ ++++
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65 7LES_DROME 1339 SC-W--VGSELHEELRLNQSAlEARVEHLQPDQTYHFQVEARVAATgaaa 1385
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66
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67 CS CCCC
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68 GpeS<-*
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69 G++S
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70 7LES_DROME 1386 GAAS 1389
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71
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72 fn3: domain 4 of 6, from 1799 to 1891: score 63.5, E = 2.3e-19
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73 CS CCCCCEEEEEECCTTCCEEEEECCC CCCCCCCEEEEE.ECCCCCC
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74 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge.
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75 Ps+P+n++v+ +++ +l +sW pp++ +++ +Y++++ q++ +ge+
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76 7LES_DROME 1799 PSPPRNFSVRVLSPRELEVSWLPPEqLRSESVYYTLHW-QQELDGEn 1844
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77
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78 CS CCCCEEECCCCCECECCEEEEECCCCEEEEEECCC CCCC
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79 .......wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-*
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80 +++++ + + + t+ ++ ltg kPg+ Y+++VqA+ + +++ S
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81 7LES_DROME 1845 vqdrrewEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTkSNSS 1891
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82
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83 fn3: domain 5 of 6, from 1899 to 1978: score 15.2, E = 1.5e-06
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84 CS CCCCCEEEEEECCTTCCEEEEECCCCCCCCCCEEEEE.ECCCCCCCC
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85 *->PsaPtnltvtdvtstsltlsWspptgngpitgYevtyRqpknggewn
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86 + l+ +++++sl+l+W p+ + ++++R ++ e
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87 7LES_DROME 1899 FAELPELQLLELGPYSLSLTWAGT--PDPLGSLQLECR---SSAEQL 1940
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88
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89 CS CCEEECCCCCECECCEEEEECCCCEEEEEECCC CCCC
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90 eltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-*
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91 +++v g+ t ++++ L+P t+Y+ r+ ++++G++
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92 7LES_DROME 1941 RRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATpGAPL 1978
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93
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94 fn3: domain 6 of 6, from 1993 to 2107: score 20.3, E = 4.3e-07
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95 CS CCCCCEEEEEECCTTCCEEEEECCC CCCCCCCEEEEE.ECCCCCC
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96 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge.
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97 Ps+P+ ++ + + + ++++W++++++++pi Y+++ ++++ +
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98 7LES_DROME 1993 PSQPGKPQLEHIAEEVFRVTWTAARgNGAPIALYNLEA-LQARSDIr 2038
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99
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100 CS CCCCEEECCCC CECECCEEEEE
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101 ...........................wneltvpgttt.sytltgLkPgt
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102 +++++++++++++ ++ + +++ ++++l+ +tt s++++ L +
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103 7LES_DROME 2039 rrrrrrrrnsggsleqlpwaeepvvveDQWLDFCNTTElSCIVKSLHSSR 2088
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104
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105 CS CCCCEEEEEE CCC CCCC
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106 eYevrVqAvn.ggG.GpeS<-*
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107 +rV+A++ ++G Gp+S
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108 7LES_DROME 2089 LLLFRVRARSlEHGwGPYS 2107
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109
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110 pkinase: domain 1 of 1, from 2209 to 2483: score 314.6, E = 6e-95
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111 *->yelleklGeGsfGkVykakhkd...ktgkiVAvKilkkekesikekr
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112 ++ll+ lG+G+fG+Vy++++k+++++ ++VA+K l+k+++++ e
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113 7LES_DROME 2209 LKLLRFLGSGAFGEVYEGQLKTedsEEPQRVAIKSLRKGASEFAE-- 2253
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114
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115 flrEiqilkrLsHpNIvrligvfedtddhlylvmEymegGdLfdylrrng
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116 +l E+q++ +++H+NIvrl g++ + +++ l+mE+me GdL++ylr+ +
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117 7LES_DROME 2254 LLQEAQLMSNFKHENIVRLVGICF-DTESISLIMEHMEAGDLLSYLRAAR 2302
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118
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119 ..........gplsekeakkialQilrGleYLHsngivHRDLKpeNILld
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120 +++++++++ ls e++ ++ ++++G +YL+++++vHRDL+ +N+L++
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121 7LES_DROME 2303 atstqepqptAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVT 2352
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122
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123 en......dgtvKiaDFGLArlle..sssklttfvGTpwYmmAPEvileg
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124 e +++++++ tvKi+DFGLAr++++++++++ + + p+++m+PE l +
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125 7LES_DROME 2353 EStgstdrRRTVKIGDFGLARDIYksDYYRKEGEGLLPVRWMSPES-LVD 2401
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126
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127 rgysskvDvWSlGviLyElltggplfpgadlpaftggdevdqliifvlkl
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128 +++++DvW++Gv+++E+lt g ++
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129 7LES_DROME 2402 GLFTTQSDVWAFGVLCWEILTLG-------------------------QQ 2426
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130
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131 PfsdelpktridpleelfriikrpglrlplpsncSeelkdLlkkcLnkDP
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132 P+ ++ +e+++++k+ g+rl +p+ c e l++Ll c++ DP
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133 7LES_DROME 2427 PYAA-------RNNFEVLAHVKE-GGRLQQPPMCTEKLYSLLLLCWRTDP 2468
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134
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135 skRpGsatakeilnhpwf<-*
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136 ++Rp +++ + n +
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137 7LES_DROME 2469 WERP---SFRRCYNTLHA 2483
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138
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139 rrm: domain 1 of 1, from 2223 to 2284: score -40.4, E = 0.72
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140 *->lfVgNL.......ppdvteedLkdlFskfGpi.vsikivkDhkektk
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141 ++ g L+++++++p+ v + L++ s+f + +++++ +
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142 7LES_DROME 2223 VYEGQLktedseePQRVAIKSLRKGASEFAELlQEAQLMSN------ 2263
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143
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144 etgkskGfaFVeFeseedAekAlealnGkelggrklrv<-*
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145 F+ e+ ++ l G+ ++ +
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146 7LES_DROME 2264 ------------FKH----ENIVR-LVGICFDTESISL 2284
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147
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148 //
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