Mercurial > repos > bimib > cobraxy
changeset 305:59d2ada8d1a6 draft
Uploaded
| author | francesco_lapi |
|---|---|
| date | Tue, 20 May 2025 14:53:37 +0000 |
| parents | 4f5c45de5936 |
| children | 81497dd6e4a0 |
| files | COBRAxy/.gitignore COBRAxy/local/svg metabolic maps/ENGRO2_map.svg COBRAxy/local/svg metabolic maps/ENGRO2_no_legend_map.svg flux_to_map.xml |
| diffstat | 4 files changed, 5522 insertions(+), 11967 deletions(-) [+] |
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--- a/COBRAxy/.gitignore Tue May 20 14:50:20 2025 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,6 +0,0 @@ -__pycache__/ -cobraxy.egg-info/ -.venv/ -.vscode/ -outputs/ -build/ \ No newline at end of file
--- a/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Tue May 20 14:50:20 2025 +0000 +++ b/COBRAxy/local/svg metabolic maps/ENGRO2_map.svg Tue May 20 14:53:37 2025 +0000 @@ -6,30 +6,63 @@ fill="none" version="1.1" id="svg1344" - sodipodi:docname="mappaENGRO2.svg" - inkscape:version="1.4 (86a8ad7, 2024-10-11)" + sodipodi:docname="ENGRO2_map.svg" + inkscape:version="1.3 (0e150ed6c4, 2023-07-21)" + xml:space="preserve" xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape" xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd" + xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" - xmlns:svg="http://www.w3.org/2000/svg"> - <defs - id="defs1344"> - <inkscape:perspective + xmlns:svg="http://www.w3.org/2000/svg"><defs + id="defs1344"><pattern + inkscape:collect="always" + xlink:href="#invert grid" + preserveAspectRatio="xMidYMid" + id="pattern17" + patternTransform="matrix(2,0,0,2,-20.576263,-22.634197)" + x="5" + y="2" /><pattern + patternUnits="userSpaceOnUse" + width="12" + height="12" + preserveAspectRatio="xMidYMid" + id="invert grid" + x="0" + y="0" + style="fill:#9d9d9d" + inkscape:label="Griglia invertita" + inkscape:collect="always" + inkscape:isstock="true"><rect + style="stroke:none;paint-order:markers fill stroke" + id="rect2-0" + width="10" + height="10" + x="0" + y="0" /></pattern><linearGradient + id="linearGradient10" + inkscape:collect="always"><stop + style="stop-color:#000000;stop-opacity:1;" + offset="0" + id="stop11" /><stop + style="stop-color:#000000;stop-opacity:0;" + offset="1" + id="stop12" /></linearGradient><linearGradient + id="swatch10" + inkscape:swatch="solid"><stop + style="stop-color:#8e9999;stop-opacity:0.34076436;" + offset="0" + id="stop10" /></linearGradient><inkscape:perspective sodipodi:type="inkscape:persp3d" inkscape:vp_x="0 : 1344 : 1" inkscape:vp_y="0 : 1000 : 0" inkscape:vp_z="2632 : 1344 : 1" inkscape:persp3d-origin="1316 : 942 : 1" - id="perspective1" /> - <linearGradient + id="perspective1" /><linearGradient id="swatch2" - inkscape:swatch="solid"> - <stop + inkscape:swatch="solid"><stop style="stop-color:#000000;stop-opacity:1;" offset="0" - id="stop2" /> - </linearGradient> - <inkscape:path-effect + id="stop2" /></linearGradient><inkscape:path-effect effect="bspline" id="path-effect1" is_visible="true" @@ -40,66 +73,62 @@ apply_no_weight="true" apply_with_weight="true" only_selected="false" - uniform="false" /> - <mask + uniform="false" /><mask id="path-133-outside-1_498_2" maskUnits="userSpaceOnUse" x="75" y="49" width="2514" height="2192" - fill="#000000"> - <rect + fill="#000000"><rect fill="#ffffff" x="75" y="49" width="2514" height="2192" - id="rect285" /> - <path + id="rect285" /><path d="m 81,67 c 0,-6.6274 5.3726,-12 12,-12 h 2478 c 6.63,0 12,5.3726 12,12 v 2156 c 0,6.63 -5.37,12 -12,12 H 93 c -6.6275,0 -12,-5.37 -12,-12 z" - id="path287" /> - </mask> - <mask + id="path287" /></mask><mask id="path-133-outside-1_498_2-1" maskUnits="userSpaceOnUse" x="75" y="49" width="2514" height="2192" - 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inkscape:zoom="0.87681241" - inkscape:cx="628.98289" - inkscape:cy="2327.1797" - inkscape:window-width="2560" - inkscape:window-height="1494" - inkscape:window-x="-11" - inkscape:window-y="-11" + inkscape:zoom="0.43840621" + inkscape:cx="900.9909" + inkscape:cy="2409.8655" + inkscape:window-width="1920" + inkscape:window-height="1009" + inkscape:window-x="-8" + inkscape:window-y="-8" inkscape:window-maximized="1" inkscape:current-layer="Legend body" - showgrid="true"> - <inkscape:grid + showgrid="true"><inkscape:grid id="grid1" units="px" originx="0" @@ -131,17 +159,13 @@ opacity="0.14901961" empspacing="5" enabled="true" - visible="true" /> - </sodipodi:namedview> - <g + visible="true" /></sodipodi:namedview><g id="ENGRO2_2" transform="translate(-8.072989,-1.5474262)" - style="display:inline"> - <g + style="display:inline"><g id="Legend" inkscape:label="Legend" - transform="translate(-44.507011,31.2884)"> - <text + transform="translate(-44.507011,31.2884)"><text id="text39" fill="#000000" xml:space="preserve" @@ -152,10 +176,8 @@ letter-spacing="0em"><tspan x="98.234398" y="2289.5901" - id="tspan1">Legend:</tspan></text> - <g - id="Legend body"> - <text + id="tspan1">Legend:</tspan></text><g + id="Legend body"><text id="text35" fill="#000000" xml:space="preserve" @@ -164,11 +186,11 @@ font-size="24px" font-weight="bold" letter-spacing="0em" - y="-2.2556152"><tspan - x="220.246" - y="2348.0645" - id="tspan2">= Up-regulated in dataset1</tspan></text> - <text + y="-2.8258626" + x="-61.58672"><tspan + x="158.65929" + y="2347.4941" + id="tspan2">Up-regulated in dataset1</tspan></text><text id="text35-8" fill="#000000" xml:space="preserve" @@ -177,12 +199,11 @@ font-size="24px" font-weight="bold" letter-spacing="0em" - x="-1.001358e-05" - y="37.593956"><tspan - x="220.246" - y="2387.9141" - id="tspan2-8">= Down-regulated in dataset 2</tspan></text> - <text + x="-59.875988" + y="42.726181"><tspan + x="160.37003" + y="2393.0464" + id="tspan2-8">Down-regulated in dataset2</tspan></text><text id="text_first_condition" fill="#000000" xml:space="preserve" @@ -191,12 +212,11 @@ font-size="24px" font-weight="bold" letter-spacing="0em" - x="-6.4373016e-06" - y="77.747986"><tspan - x="220.246" - y="2428.0681" - id="tspan2-8-4">= Flux-inversion: the flux is in the same direction of the arrow in dataset1, in the opposite direction in dataset2.</tspan></text> - <text + x="432.39621" + y="1.334836"><tspan + x="652.64221" + y="2351.655" + id="tspan2-8-4">Flux-inversion: same direction of the arrow in dataset1, opposite direction in dataset2.</tspan></text><text id="text35-8-2-7" fill="#000000" xml:space="preserve" @@ -205,12 +225,11 @@ font-size="24px" font-weight="bold" letter-spacing="0em" - x="532.15442" - y="37.59375"><tspan - x="752.40045" - y="2387.9141" - id="tspan2-8-4-1">= Fold change under threshold</tspan></text> - <text + x="432.39624" + y="95.966736"><tspan + x="652.64221" + y="2446.2871" + id="tspan2-8-4-1">Fold change under threshold</tspan></text><text id="text35-8-2-7-2" fill="#000000" xml:space="preserve" @@ -219,12 +238,11 @@ font-size="24px" font-weight="bold" letter-spacing="0em" - x="1036.3861" - y="0.27544641"><tspan - x="1256.6321" - y="2350.5957" - id="tspan2-8-4-1-3">= Not classified</tspan></text> - <text + x="-59.179775" + y="152.82613"><tspan + x="161.06625" + y="2503.1462" + id="tspan2-8-4-1-3">Not classified</tspan></text><text id="text35-8-2-7-7" fill="#000000" xml:space="preserve" @@ -233,12 +251,11 @@ font-size="24px" font-weight="bold" letter-spacing="0em" - x="529.78455" - y="-2.1092134"><tspan - x="750.03052" - y="2348.2109" - id="tspan2-8-4-1-6">= Not significant</tspan></text> - <text + x="-55.995022" + y="96.259903"><tspan + x="164.25095" + y="2446.5801" + id="tspan2-8-4-1-6">Not significant</tspan></text><text id="text_second_condition" fill="#000000" xml:space="preserve" @@ -247,84 +264,61 @@ font-size="24px" font-weight="bold" letter-spacing="0em" - x="-6.6757202e-06" - y="117.59757"><tspan - x="220.246" - y="2467.9177" - id="tspan2-8-4-5">= Flux-inversion: the flux is in the same direction of the arrow in dataset2, in the opposite direction in dataset1.</tspan></text> - <path + x="432.39621" + y="43.46542"><tspan + x="652.64221" + y="2393.7856" + id="tspan2-8-4-5">Flux-inversion: same direction of the arrow in dataset2, opposite direction in dataset1.</tspan></text><path id="path6613-8-6" - 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stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text2692_2" transform="translate(351,2195)" fill="#000000" @@ -1922,10 +1680,8 @@ letter-spacing="0em"><tspan x="0.48828101" y="11.1602" - id="tspan652">NADPH</tspan></text> - <g - id="text2696_2"> - <text + id="tspan652">NADPH</tspan></text><g + id="text2696_2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -1935,8 +1691,7 @@ id="text657"><tspan x="301.22198" y="2206.1599" - id="tspan655">NADP</tspan></text> - <text + id="tspan655">NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -1946,17 +1701,12 @@ id="text661"><tspan x="334.573" y="2206.1599" - id="tspan659">⁺</tspan></text> - </g> - </g> - <g - id="Group 125"> - <path + id="tspan659">⁺</tspan></text></g></g><g + id="Group 125"><path id="F_MTHFR3" d="m 157.001,2159.44 c 1.375,-9.44 1.375,-9.44 1.375,-9.44 l 2.865,9.05 -2.306,-2.12 z m -4.606,10.98 c -9.41,-1.56 -9.41,-1.56 -9.41,-1.56 l 9.109,-2.69 -2.165,2.27 z" stroke="#000000" - 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id="tspan431">ADP</tspan></text> - <path + id="tspan431">ADP</tspan></text><path id="R_CRTNsyn_cho" d="m 228,1681 c 0,14.5 -20.25,14.5 -20.25,14.5 -20.25,0 -20.25,-14.5 -20.25,-14.5 m 40.5,14.5 h -40.5" stroke="#000000" - stroke-width="2.30969" /> - <path + stroke-width="2.30969" /><path id="F_CRTNsyn_cho" fill-rule="evenodd" clip-rule="evenodd" d="m 185.672,1682.86 c 1.828,-9.36 1.828,-9.36 1.828,-9.36 l 2.426,9.18 -2.201,-2.23 z m 3.178,15.33 c -9.621,-3.23 -9.621,-3.23 -9.621,-3.23 l 9.833,-2.52 -2.538,2.78 z" stroke="#000000" - stroke-width="2.30969" /> - <text + stroke-width="2.30969" /><text id="text5458" fill="#000000" xml:space="preserve" @@ -2296,10 +2003,8 @@ letter-spacing="0em"><tspan x="96.343597" y="1699.55" - id="tspan436">Creatinine</tspan></text> - <g - id="text5464"> - <text + id="tspan436">Creatinine</tspan></text><g + id="text5464"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2309,8 +2014,7 @@ id="text441"><tspan x="224.062" y="1679.16" - id="tspan439">H</tspan></text> - 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stroke-width="2.49462" /> - <path + stroke-width="2.49462" /><path id="F_CRTNtr" fill-rule="evenodd" clip-rule="evenodd" d="m 55.2892,1693.93 3.0311,2.98 -12.296,-3.06 12.4107,-2.85 z" stroke="#000000" - stroke-width="2.62587" /> - <path + stroke-width="2.62587" /><path id="R_GUDACtr2" d="M 57,1780.5 H 381.5" stroke="#000000" - stroke-width="2.53856" /> - <path + stroke-width="2.53856" /><path id="F_GUDACtr2" fill-rule="evenodd" clip-rule="evenodd" d="m 58.2887,1780.93 3.0231,2.98 -12.2874,-3.05 12.4178,-2.86 z" stroke="#000000" - stroke-width="2.62587" /> - </g> - <g + stroke-width="2.62587" /></g><g id="path_glutathione" - transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"><g id="g34" - inkscape:label="box_glutathione"> - <path + inkscape:label="box_glutathione"><path id="Rectangle 3_9" d="m 2571,2212 v -108 c 0,-6.63 -5.37,-12 -12,-12 H 2522.77 2109 c -6.63,0 -12,5.37 -12,12 v 108 c 0,6.63 5.37,12 12,12 h 450 c 6.63,0 12,-5.37 12,-12 z" fill="#aeaeae" - fill-opacity="0.1" /> - <path + fill-opacity="0.1" /><path id="Rectangle 2_9" d="M 2350.2145,2079 H 2546.5 c 6.63,0 12,5.37 12,12 v 109 c 0,6.63 -5.37,12 -12,12 H 2097 c -6.63,0 -12,-5.37 -12,-12 v -109 c 0,-6.63 5.37,-12 12,-12 h 8.5" stroke="#aeaeae" stroke-width="4" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_9" fill="#000000" xml:space="preserve" @@ -2400,17 +2090,13 @@ letter-spacing="0em"><tspan x="2114" y="2085.4299" - id="tspan763">Glutathione synthesis</tspan></text> - <circle + id="tspan763">Glutathione synthesis</tspan></text><circle id="Ellipse 1_9" cx="2350.0625" cy="2079" r="6" - fill="#aeaeae" /> - </g> - <g - id="Group 135"> - <text + fill="#aeaeae" /></g><g + id="Group 135"><text id="text3860-8" fill="#000000" xml:space="preserve" @@ -2421,8 +2107,7 @@ letter-spacing="0em"><tspan x="2112.3799" y="2139.55" - id="tspan788">GSSG</tspan></text> - <text + id="tspan788">GSSG</tspan></text><text id="text3860-8-1" fill="#000000" xml:space="preserve" @@ -2435,10 +2120,8 @@ y="141.89951"><tspan x="2103.3118" y="2281.4497" - id="tspan788-2">GSSG</tspan></text> - <g - id="Group 130"> - <text + id="tspan788-2">GSSG</tspan></text><g + id="Group 130"><text id="text7967-0-3-9-1-8-0-3" fill="#000000" xml:space="preserve" @@ -2449,8 +2132,7 @@ letter-spacing="0em"><tspan x="2267.1599" y="2138.55" - id="tspan791">GSH</tspan></text> - <text + id="tspan791">GSH</tspan></text><text id="text7967-0-3-9-1-8-0-3-6" fill="#000000" xml:space="preserve" @@ -2463,15 +2145,12 @@ y="147.07513"><tspan x="2271.7202" y="2285.6252" - id="tspan791-2">GSH</tspan></text> - <path + id="tspan791-2">GSH</tspan></text><path id="F_GTHPi" d="m 2172.55,2133.74 c -9.67,-3.1 -9.67,-3.1 -9.67,-3.1 l 9.8,-2.65 -2.5,2.82 z m 9.08,-11.56 c 2.85,-6.57 2.85,-6.57 2.85,-6.57 l 2.67,6.61 -2.74,-1.67 z" stroke="#000000" - stroke-width="1.90098" /> - <g - id="text3878-1"> - <text + stroke-width="1.90098" /><g + id="text3878-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2481,8 +2160,7 @@ id="text797"><tspan x="2191.0601" y="2154.1599" - id="tspan795">H</tspan></text> - <text + id="tspan795">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2492,9 +2170,7 @@ id="text801"><tspan x="2199.73" y="2154.1599" - id="tspan799">⁺</tspan></text> - </g> - <text + id="tspan799">⁺</tspan></text></g><text id="text3878-1_2" fill="#000000" xml:space="preserve" @@ -2504,10 +2180,8 @@ letter-spacing="0em"><tspan x="2147.49" y="2154.1599" - id="tspan804">NADH</tspan></text> - <g - id="text3882-4"> - <text + id="tspan804">NADH</tspan></text><g + id="text3882-4"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2517,8 +2191,7 @@ id="text809"><tspan x="2207.22" y="2160.1599" - id="tspan807">NAD</tspan></text> - <text + id="tspan807">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2528,11 +2201,8 @@ id="text813"><tspan x="2232.5701" y="2160.1599" - id="tspan811">⁺</tspan></text> - </g> - <g - id="text3902-2"> - <text + id="tspan811">⁺</tspan></text></g><g + id="text3902-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2545,8 +2215,7 @@ id="tspan816">H</tspan><tspan x="2224.27" y="2117.1599" - id="tspan818">O</tspan></text> - <text + id="tspan818">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2559,9 +2228,7 @@ id="tspan822">₂</tspan><tspan x="2233.6101" y="2117.1599" - id="tspan824">₂</tspan></text> - </g> - <text + id="tspan824">₂</tspan></text></g><text id="text3910-9" fill="#000000" xml:space="preserve" @@ -2571,15 +2238,12 @@ letter-spacing="0em"><tspan x="2243.49" y="2117.1599" - id="tspan829">GSH</tspan></text> - <path + id="tspan829">GSH</tspan></text><path id="R_GTHPi" d="m 2205.5,2130.96 c 17,0.09 17,-9.96 17,-9.96 m 36.6,10.22 -89.59,-0.43 m 69.49,0.34 c 16,0.07 16,-10.13 16,-10.13 m -70.5,0 c 0,9.86 21.41,9.96 21.41,9.96" stroke="#000000" - stroke-width="2.38381" /> - <g - id="text3929-9"> - <text + stroke-width="2.38381" /><g + id="text3929-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2592,8 +2256,7 @@ id="tspan833">2 H</tspan><tspan x="2191.29" y="2112.1599" - id="tspan835">O</tspan></text> - <text + id="tspan835">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2603,9 +2266,7 @@ id="text841"><tspan x="2187.0601" y="2112.1599" - id="tspan839">₂</tspan></text> - </g> - <text + id="tspan839">₂</tspan></text></g><text id="text3964-2" fill="#000000" xml:space="preserve" @@ -2615,21 +2276,16 @@ letter-spacing="0em"><tspan x="2241.49" y="2160.1599" - id="tspan844">GSH</tspan></text> - <path + id="tspan844">GSH</tspan></text><path id="R_GDR" d="m 2213.5,2137.98 c 10,0 10,5.02 10,5.02 m -60.5,-5.02 c 0,0 9.45,0 15.5,0 m 78,0 c 0,0 -47.54,0 -78,0 m 61,0 c 10.5,0 10.5,5.02 10.5,5.02 m -45,-5.02 c -9.5,0 -9.5,5.02 -9.5,5.02 m -17,-5.02 c -15.5,0 -15.5,5.02 -15.5,5.02" stroke="#000000" - stroke-width="1.39417" /> - <path + stroke-width="1.39417" /><path id="F_GDR" d="m 2220.22,2141.87 c 2.85,6.57 2.85,6.57 2.85,6.57 l 2.67,-6.61 -2.74,1.67 z m 27,0.5 c 2.85,6.57 2.85,6.57 2.85,6.57 l 2.67,-6.61 -2.74,1.67 z m 7.53,-1.29 c 9.66,-3.1 9.66,-3.1 9.66,-3.1 l -9.79,-2.65 2.5,2.82 z" stroke="#000000" - stroke-width="1.90098" /> - </g> - <g - id="text3999-9"> - <text + stroke-width="1.90098" /></g><g + id="text3999-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2639,8 +2295,7 @@ id="text852"><tspan x="2221.22" y="2198.1599" - 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inkscape:label="F_DmGSSG" /> - </g> - <g - id="Group 132"> - <path + inkscape:label="F_DmGSSG" /></g><g + id="Group 132"><path id="R_GTHRDt2" d="M 2296.25,2152.65 V 2266.5" stroke="#000000" - stroke-width="2.50699" /> - <path + stroke-width="2.50699" /><path id="F_GTHRDt2" fill-rule="evenodd" clip-rule="evenodd" d="m 2296.01,2150.26 -3.01,3.01 3.17,-12.27 2.74,12.44 z" stroke="#000000" - stroke-width="2.62587" /> - </g> - <text + stroke-width="2.62587" /></g><text id="text7967-0-3-9-1-5-9" fill="#000000" xml:space="preserve" @@ -2751,8 +2388,7 @@ letter-spacing="0em"><tspan x="2395.49" y="2138.55" - id="tspan882">GC</tspan></text> - <text + id="tspan882">GC</tspan></text><text id="text5921" fill="#000000" xml:space="preserve" @@ -2763,10 +2399,8 @@ letter-spacing="0em"><tspan x="2515.3101" y="2138.55" - id="tspan885">Cys</tspan></text> - <g - id="Group 133"> - <text + id="tspan885">Cys</tspan></text><g + id="Group 133"><text id="text7967-0-3-7-5-8-7-2-7" fill="#000000" xml:space="preserve" @@ -2776,18 +2410,15 @@ letter-spacing="0em"><tspan x="2383.27" y="2123.1599" - id="tspan888">ATP</tspan></text> - <path + id="tspan888">ATP</tspan></text><path id="R_GTHS" d="m 2317,2134.06 h 42.5 m 33,0 h -33 m -10,-9.06 c 0,9.06 10,9.06 10,9.06 m 0,0 c 0,0 9,0 9,-9.06 m -36,9.06 c -9.5,0 -9.5,-9.06 -9.5,-9.06 m 69.5,0 c 0,9.06 -9,9.06 -9,9.06" stroke="#000000" - stroke-width="1.68137" /> - <path + stroke-width="1.68137" /><path id="F_GTHS" d="m 2320.65,2126.2 c 2.35,-9.24 2.35,-9.24 2.35,-9.24 l 1.9,9.3 -2.07,-2.35 z m -1.86,10.75 c -3.26,-0.89 -6.53,-1.78 -9.79,-2.68 3.22,-1.02 6.45,-2.04 9.67,-3.07 -0.79,0.98 -1.58,1.95 -2.37,2.93 0.83,0.94 1.66,1.88 2.49,2.82 z" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-3-7-5-8-7-2-7-8" fill="#000000" xml:space="preserve" @@ -2797,8 +2428,7 @@ letter-spacing="0em"><tspan x="2360.49" y="2123.1599" - id="tspan893">Gly</tspan></text> - <text + id="tspan893">Gly</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7" fill="#000000" xml:space="preserve" @@ -2808,8 +2438,7 @@ letter-spacing="0em"><tspan x="2343.1599" y="2116.1599" - id="tspan896">Pi</tspan></text> - <text + id="tspan896">Pi</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7_2" fill="#000000" xml:space="preserve" @@ -2819,11 +2448,8 @@ letter-spacing="0em"><tspan x="2312.1599" y="2114.1599" - id="tspan899">ADP</tspan></text> - </g> - <g - id="Group 134"> - <text + id="tspan899">ADP</tspan></text></g><g + id="Group 134"><text id="text7967-0-3-7-5-8-7-2-7_2" fill="#000000" xml:space="preserve" @@ -2833,18 +2459,15 @@ letter-spacing="0em"><tspan x="2501.27" y="2123.1599" - id="tspan903">ATP</tspan></text> - <path + id="tspan903">ATP</tspan></text><path id="R_GLUCYS" d="m 2435,2134.06 h 42.5 m 33,0 h -33 m -10,-9.06 c 0,9.06 10,9.06 10,9.06 m 0,0 c 0,0 9,0 9,-9.06 m -36,9.06 c -9.5,0 -9.5,-9.06 -9.5,-9.06 m 69.5,0 c 0,9.06 -9,9.06 -9,9.06" stroke="#000000" - stroke-width="1.68137" /> - <path + stroke-width="1.68137" /><path id="F_GLUCYS" d="m 2438.65,2126.2 c 2.35,-9.24 2.35,-9.24 2.35,-9.24 l 1.9,9.3 -2.07,-2.35 z m -1.86,10.75 c -3.26,-0.89 -6.53,-1.78 -9.79,-2.68 3.22,-1.02 6.45,-2.04 9.67,-3.07 -0.79,0.98 -1.58,1.95 -2.37,2.93 0.83,0.94 1.66,1.88 2.49,2.82 z" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-3-7-5-8-7-2-7-8_2" fill="#000000" xml:space="preserve" @@ -2854,8 +2477,7 @@ letter-spacing="0em"><tspan x="2478.1499" y="2123.1599" - id="tspan908">Glu</tspan></text> - <text + id="tspan908">Glu</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7_3" fill="#000000" xml:space="preserve" @@ -2865,8 +2487,7 @@ letter-spacing="0em"><tspan x="2461.1599" y="2116.1599" - id="tspan911">Pi</tspan></text> - <text + id="tspan911">Pi</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7_4" fill="#000000" xml:space="preserve" @@ -2876,30 +2497,22 @@ letter-spacing="0em"><tspan x="2430.1599" y="2114.1599" - id="tspan914">ADP</tspan></text> - </g> - </g> - </g> - <g + id="tspan914">ADP</tspan></text></g></g></g><g id="path_biomass" - transform="matrix(0.99609327,0,0,0.99818223,7.6974935,404.18463)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,7.6974935,404.18463)"><g id="g33" - inkscape:label="box_biomass"> - <path + inkscape:label="box_biomass"><path id="Rectangle 3_7" d="m 2548.5663,1564.9748 v -542 c 0,-6.63 -5.2478,-12 -11.727,-12 h -42.6572 -468.4472 c -6.4792,0 -11.7271,5.37 -11.7271,12 v 542 c 0,6.63 5.2479,12 11.7271,12 h 511.1044 c 6.4792,0 11.727,-5.37 11.727,-12 z" fill="#f018ce" fill-opacity="0.1" - style="stroke-width:0.988562" /> - <path + style="stroke-width:0.988562" /><path id="Rectangle 2_7" d="m 2145.7441,1011.9698 h 389.6473 c 6.4304,0 11.6388,5.3706 11.6388,12.0013 v 543.0578 c 0,6.6307 -5.2084,12.0013 -11.6388,12.0013 H 2028.132 c -6.4305,0 -11.6389,-5.3706 -11.6389,-12.0013 v -543.0578 c 0,-6.6307 5.2084,-12.0013 11.6389,-12.0013 h 8.2442" stroke="#f018ce" stroke-width="3.93956" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_7" fill="#000000" xml:space="preserve" @@ -2912,17 +2525,13 @@ y="-0.51527369"><tspan x="2039.8434" y="1017.9147" - id="tspan749">Biomass</tspan></text> - <circle + id="tspan749">Biomass</tspan></text><circle id="Ellipse 1_7" cx="2133.0391" cy="1012" r="6" - fill="#f018ce" /> - </g> - <g - id="Group 32"> - <text + fill="#f018ce" /></g><g + id="Group 32"><text id="text5640-6" fill="#2b0000" xml:space="preserve" @@ -2933,8 +2542,7 @@ x="2034.53" y="1290.37" id="tspan4670" - style="fill:#000000">0.01 dTTP</tspan></text> - <text + style="fill:#000000">0.01 dTTP</tspan></text><text id="text5562-2" fill="#2b0000" xml:space="preserve" @@ -2945,8 +2553,7 @@ x="2033.84" y="1209.63" id="tspan4673" - style="fill:#000000">0.01 dATP</tspan></text> - <text + style="fill:#000000">0.01 dATP</tspan></text><text id="text5543-5" fill="#2b0000" xml:space="preserve" @@ -2957,8 +2564,7 @@ x="2031.09" y="1263.46" id="tspan4676" - style="fill:#000000">0.01 dGTP</tspan></text> - <text + style="fill:#000000">0.01 dGTP</tspan></text><text id="text7967-0-3-6-2-0-0" fill="#2b0000" xml:space="preserve" @@ -2969,8 +2575,7 @@ x="2042.22" y="1182.1899" id="tspan4679" - style="fill:#000000">0.05 UTP</tspan></text> - <text + style="fill:#000000">0.05 UTP</tspan></text><text id="text5590-1" fill="#2b0000" xml:space="preserve" @@ -2981,8 +2586,7 @@ x="2032.47" y="1236.55" id="tspan4682" - style="fill:#000000">0.01 dCTP</tspan></text> - <text + style="fill:#000000">0.01 dCTP</tspan></text><text id="text7967-0-3-6-2-7-4-6" fill="#2b0000" xml:space="preserve" @@ -2993,8 +2597,7 @@ x="2048.21" y="1155.49" id="tspan4685" - style="fill:#000000">0.04CTP</tspan></text> - <text + style="fill:#000000">0.04CTP</tspan></text><text id="text7967-0-5-1-1" fill="#2b0000" xml:space="preserve" @@ -3005,8 +2608,7 @@ x="2034.42" y="1331.8199" id="tspan4688" - style="fill:#000000">0.27 Palm</tspan></text> - <text + style="fill:#000000">0.27 Palm</tspan></text><text id="text7967-0-8" fill="#2b0000" xml:space="preserve" @@ -3017,10 +2619,8 @@ x="2037.84" y="1357.36" id="tspan4691" - style="fill:#000000">0.20 Chol</tspan></text> - <g - id="a14389-3"> - <text + style="fill:#000000">0.20 Chol</tspan></text><g + id="a14389-3"><text id="text6883-6" fill="#2b0000" xml:space="preserve" @@ -3031,11 +2631,8 @@ x="2041.97" y="1394.83" id="tspan4694" - style="fill:#000000">0.28 G6P</tspan></text> - </g> - <g - id="a14389-3-9"> - <text + style="fill:#000000">0.28 G6P</tspan></text></g><g + id="a14389-3-9"><text id="text6883-6-8" fill="#2b0000" xml:space="preserve" @@ -3046,8 +2643,7 @@ x="2031" y="1419.7" id="tspan4698" - style="fill:#000000">20.65 H20</tspan></text> - <text + style="fill:#000000">20.65 H20</tspan></text><text id="text6883-6-8-0" fill="#2b0000" xml:space="preserve" @@ -3058,9 +2654,7 @@ x="2032.34" y="1443.1899" id="tspan4701" - style="fill:#000000">20.70 ATP</tspan></text> - </g> - <text + style="fill:#000000">20.70 ATP</tspan></text></g><text id="text4694-5" fill="#2b0000" xml:space="preserve" @@ -3071,8 +2665,7 @@ x="2043.4" y="1128.58" id="tspan4705" - style="fill:#000000">0.04 GTP</tspan></text> - <text + style="fill:#000000">0.04 GTP</tspan></text><text id="text5640-6-2" fill="#2b0000" xml:space="preserve" @@ -3083,8 +2676,7 @@ x="2448.8" y="1177.9" id="tspan4708" - style="fill:#000000">0.36 Arg</tspan></text> - <text + style="fill:#000000">0.36 Arg</tspan></text><text id="text5562-2-6" fill="#2b0000" xml:space="preserve" @@ -3095,8 +2687,7 @@ x="2448.1001" y="1248.71" id="tspan4711" - style="fill:#000000">0.05 Cys</tspan></text> - <text + style="fill:#000000">0.05 Cys</tspan></text><text id="text5543-5-4" fill="#2b0000" xml:space="preserve" @@ -3107,8 +2698,7 @@ x="2448.1001" y="1319.61" id="tspan4714" - style="fill:#000000">0.39 Glu</tspan></text> - <text + style="fill:#000000">0.39 Glu</tspan></text><text id="text7967-0-3-6-2-0-0-7" fill="#2b0000" xml:space="preserve" @@ -3119,8 +2709,7 @@ x="2448.8" y="1224.96" id="tspan4717" - style="fill:#000000">0.35 Asp</tspan></text> - <text + style="fill:#000000">0.35 Asp</tspan></text><text id="text5590-1-2" fill="#2b0000" xml:space="preserve" @@ -3131,8 +2720,7 @@ x="2448.1001" y="1296.08" id="tspan4720" - style="fill:#000000">0.33 Gln</tspan></text> - <text + style="fill:#000000">0.33 Gln</tspan></text><text id="text7967-0-3-6-2-7-4-6-0" fill="#2b0000" xml:space="preserve" @@ -3143,8 +2731,7 @@ x="2448.8" y="1201.4301" id="tspan4723" - style="fill:#000000">0.28 Asn</tspan></text> - <text + style="fill:#000000">0.28 Asn</tspan></text><text id="text7967-0-5-1-1-1" fill="#2b0000" xml:space="preserve" @@ -3155,8 +2742,7 @@ x="2097.46" y="1489.5699" id="tspan4726" - style="fill:#000000">0.29 Ile</tspan></text> - <text + style="fill:#000000">0.29 Ile</tspan></text><text id="text7967-0-8-1" fill="#2b0000" xml:space="preserve" @@ -3167,8 +2753,7 @@ x="2096.72" y="1466.76" id="tspan4729" - style="fill:#000000">0.12 His</tspan></text> - <text + style="fill:#000000">0.12 His</tspan></text><text id="text6883-6-0" fill="#2b0000" xml:space="preserve" @@ -3179,8 +2764,7 @@ x="2448.1001" y="1272.55" id="tspan4732" - style="fill:#000000">0.54 Gly</tspan></text> - <text + style="fill:#000000">0.54 Gly</tspan></text><text id="text5640-6-2-3" fill="#2b0000" xml:space="preserve" @@ -3191,8 +2775,7 @@ x="2172.45" y="1546.84" id="tspan4735" - style="fill:#000000">0.59Lys</tspan></text> - <text + style="fill:#000000">0.59Lys</tspan></text><text id="text7967-0-3-6-2-0-0-7-5" fill="#2b0000" xml:space="preserve" @@ -3203,8 +2786,7 @@ x="2447.4299" y="1342.62" id="tspan4738" - style="fill:#000000">0.41 Pro</tspan></text> - <text + style="fill:#000000">0.41 Pro</tspan></text><text id="text7967-0-3-6-2-0-0-7-5-7" fill="#2b0000" xml:space="preserve" @@ -3215,8 +2797,7 @@ x="2389.76" y="1489.92" id="tspan4741" - style="fill:#000000">0.26 Phe</tspan></text> - <text + style="fill:#000000">0.26 Phe</tspan></text><text id="text7967-0-3-6-2-7-4-6-0-8" fill="#2b0000" xml:space="preserve" @@ -3227,8 +2808,7 @@ x="2389.77" y="1471.21" id="tspan4744" - style="fill:#000000">0.15 Met</tspan></text> - <text + style="fill:#000000">0.15 Met</tspan></text><text id="text4694-5-1-8" fill="#2b0000" xml:space="preserve" @@ -3239,8 +2819,7 @@ x="2097.05" y="1508.79" id="tspan4747" - style="fill:#000000">0.55 Leu</tspan></text> - <text + style="fill:#000000">0.55 Leu</tspan></text><text id="text5640-6-2-3-7" fill="#2b0000" xml:space="preserve" @@ -3251,8 +2830,7 @@ x="2326.96" y="1547.46" id="tspan4750" - style="fill:#000000">0.01 Trp</tspan></text> - <text + style="fill:#000000">0.01 Trp</tspan></text><text id="text7967-0-3-6-2-0-0-7-5-4" fill="#2b0000" xml:space="preserve" @@ -3263,8 +2841,7 @@ x="2391.01" y="1510.1" id="tspan4753" - style="fill:#000000">0.31Thr</tspan></text> - <text + style="fill:#000000">0.31Thr</tspan></text><text id="text7967-0-3-6-2-7-4-6-0-8-0" fill="#2b0000" xml:space="preserve" @@ -3275,8 +2852,7 @@ x="2449.01" y="1389.6801" id="tspan4756" - style="fill:#000000">0.16 Tyr</tspan></text> - <text + style="fill:#000000">0.16 Tyr</tspan></text><text id="text7967-0-3-6-2-7-4-6-0-8-0-4" fill="#2b0000" xml:space="preserve" @@ -3287,8 +2863,7 @@ x="2252.9199" y="1548.21" id="tspan4759" - style="fill:#000000">0.35Val</tspan></text> - <text + style="fill:#000000">0.35Val</tspan></text><text id="text4694-5-1-8-1" fill="#2b0000" xml:space="preserve" @@ -3299,8 +2874,7 @@ x="2447.95" y="1366.36" id="tspan4762" - style="fill:#000000">0.39 Ser</tspan></text> - <text + style="fill:#000000">0.39 Ser</tspan></text><text id="text4694-5-1" fill="#2b0000" xml:space="preserve" @@ -3311,8 +2885,7 @@ x="2448.8" y="1154.9" id="tspan4765" - style="fill:#000000">0.51 Ala</tspan></text> - <text + style="fill:#000000">0.51 Ala</tspan></text><text id="text11603-4-6" fill="#000000" xml:space="preserve" @@ -3323,8 +2896,7 @@ letter-spacing="0em"><tspan x="2232.73" y="1058.27" - id="tspan4768">Biomass</tspan></text> - <text + id="tspan4768">Biomass</tspan></text><text id="text11603-4-6-6" fill="#000000" xml:space="preserve" @@ -3334,8 +2906,7 @@ letter-spacing="0em"><tspan x="2390.53" y="1080.3101" - id="tspan4771">20.65 Pi</tspan></text> - <text + id="tspan4771">20.65 Pi</tspan></text><text id="text11603-4-6-6-0" fill="#000000" xml:space="preserve" @@ -3345,8 +2916,7 @@ letter-spacing="0em"><tspan x="2098.0601" y="1099.96" - 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inkscape:label="R_Biomass" /> - <path + inkscape:label="R_Biomass" /><path id="F_Biomass" d="m 2278.69,1068.05 -3.15,9.65 2.95,-2.35 2.8,2.51 z m 96.17,5.2 2.35,2.94 -2.52,2.81 9.81,-2.6 z m -180.3,20.63 -9.81,2.6 9.65,3.15 -2.35,-2.95 z m 182.25,8.74 2.35,2.95 -2.52,2.8 9.82,-2.6 z" stroke="#000000" - stroke-width="2.66667" /> - </g> - </g> - <g + stroke-width="2.66667" /></g></g><g id="path_cholesterol_synthesis" - transform="matrix(0.99609327,0,0,0.99818223,-21.287566,49.704866)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,-21.287566,49.704866)"><g id="g38" - inkscape:label="box_cholesterol_synthesis"> - <path + inkscape:label="box_cholesterol_synthesis"><path id="Rectangle 3_4" d="m 2357.9532,963.97816 v -246 c 0,-6.627 -5.37,-12 -12,-12 h -75.4 -759.6 c -6.63,0 -12,5.373 -12,12 v 246 c 0,6.627 5.37,12 12,12 h 835 c 6.63,0 12,-5.373 12,-12 z" fill="#cbe048" - fill-opacity="0.1" /> - <path + fill-opacity="0.1" /><path id="Rectangle 2_4" d="M 1884.8015,705 H 2345.5 c 6.63,0 12,5.373 12,12 v 246.5 c 0,6.627 -5.37,12 -12,12 H 1511 c -6.63,0 -12,-5.373 -12,-12 V 717 c 0,-6.627 5.37,-12 12,-12 h 8.5" stroke="#cbe048" stroke-width="4" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_4" fill="#000000" xml:space="preserve" @@ -3401,17 +2962,13 @@ letter-spacing="0em"><tspan x="1528" y="711.43402" - id="tspan728">Fatty acids / Cholesterol synthesis</tspan></text> - <circle + id="tspan728">Fatty acids / Cholesterol synthesis</tspan></text><circle id="Ellipse 1_4" cx="1885.0625" cy="705" r="6" - fill="#cbe048" /> - </g> - <g - id="Group 25"> - <text + fill="#cbe048" /></g><g + id="Group 25"><text id="text6997-5-1-8-3-7-8" fill="#000000" xml:space="preserve" @@ -3421,10 +2978,8 @@ letter-spacing="0em"><tspan x="1691.27" y="881.15997" - id="tspan2277">ATP</tspan></text> - <g - id="text6997-5-1-8-3-71-4"> - <text + id="tspan2277">ATP</tspan></text><g + id="text6997-5-1-8-3-71-4"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3434,8 +2989,7 @@ id="text2282"><tspan x="1747.35" y="881.15997" - id="tspan2280">HCO</tspan></text> - <text + id="tspan2280">HCO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3445,8 +2999,7 @@ id="text2286"><tspan x="1778.25" y="881.15997" - id="tspan2284">⁻</tspan></text> - <text + id="tspan2284">⁻</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3456,11 +3009,8 @@ id="text2290"><tspan x="1774.03" y="881.15997" - id="tspan2288">₃</tspan></text> - </g> - <g - id="text6997-5-1-8-3-71-2-9"> - <text + id="tspan2288">₃</tspan></text></g><g + id="text6997-5-1-8-3-71-2-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3470,8 +3020,7 @@ id="text2295"><tspan x="1725.0601" y="881.15997" - id="tspan2293">H</tspan></text> - <text + id="tspan2293">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3481,9 +3030,7 @@ id="text2299"><tspan x="1733.73" y="881.15997" - id="tspan2297">⁺</tspan></text> - </g> - <text + id="tspan2297">⁺</tspan></text></g><text id="text6997-5-1-8-3-71-5-72" fill="#000000" xml:space="preserve" @@ -3493,8 +3040,7 @@ letter-spacing="0em"><tspan x="1718.16" y="845.15997" - id="tspan2302">ADP</tspan></text> - <text + id="tspan2302">ADP</tspan></text><text id="text6997-5-1-8-3-71-5-7-37" fill="#000000" xml:space="preserve" @@ -3504,20 +3050,16 @@ letter-spacing="0em"><tspan x="1750.16" y="845.15997" - id="tspan2305">Pi</tspan></text> - <path + id="tspan2305">Pi</tspan></text><path id="R_ACCOAC" d="m 1707.68,858.5 c -5.18,0 -5.18,11.5 -5.18,11.5 m 25.5,-9.981 c 5,0 4.22,-6.671 4.22,-6.671 m 20.53,6.671 c 4.25,0 1.75,-6.667 1.75,-6.667 m -17.5,6.667 c 0,0 -18.51,0.241 -20.5,0 -55,-6.667 -232,-10.519 -232,-10.519 m 252.5,10.519 h 31.5 m -31.5,0 c -6.5,0 -6.5,9.981 -6.5,9.981 m 31.5,-9.981 c -5,0 -5,9.981 -5,9.981" stroke="#000000" - stroke-width="2.097" /> - <path + stroke-width="2.097" /><path id="F_ACCOAC" d="m 1767.2,861.406 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z m -33.74,-7.811 C 1732,848 1732,848 1732,848 l -1.12,5.649 1.25,-1.432 z m 21.87,0.783 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 L 1754,853 Z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="Group 75"> - <text + stroke-width="2.23952" /><g + id="Group 75"><text id="text6997-5-1-8-3-7-7-3-7-2-2" fill="#000000" xml:space="preserve" @@ -3527,8 +3069,7 @@ letter-spacing="0em"><tspan x="1779.3199" y="797.15997" - id="tspan2310">CoA</tspan></text> - <text + id="tspan2310">CoA</tspan></text><text id="text7967-8-1-7" fill="#000000" xml:space="preserve" @@ -3539,8 +3080,7 @@ letter-spacing="0em"><tspan x="1814.37" y="817.547" - id="tspan2313">AcACP</tspan></text> - <text + id="tspan2313">AcACP</tspan></text><text id="text6997-5-1-8-3-71-2-5-43-4-1-0" fill="#000000" xml:space="preserve" @@ -3550,23 +3090,17 @@ letter-spacing="0em"><tspan x="1769.16" y="832.15997" - id="tspan2316">ACP</tspan></text> - <path + id="tspan2316">ACP</tspan></text><path id="R_FASN" d="m 1785.42,813.498 c -3.74,0.857 -3.42,7.211 -3.42,7.211 m 7.32,-7.328 c 3.69,-0.812 2.75,-7.672 2.75,-7.672 M 1484.5,845 c 220,-35 321.5,-31.618 321.5,-31.618" stroke="#000000" - stroke-width="1.84837" /> - <path + stroke-width="1.84837" /><path id="F_FASN" d="m 1804.19,814.63 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z m -10.69,-8.13 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 74"> - <g - id="text6997-5-1-8-3-7-7-3-7"> - <text + stroke-width="2.23952" /></g><g + id="Group 74"><g + id="text6997-5-1-8-3-7-7-3-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3576,8 +3110,7 @@ id="text2324"><tspan x="1906.49" y="797.15997" - id="tspan2322">CO</tspan></text> - <text + id="tspan2322">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3587,14 +3120,11 @@ id="text2328"><tspan x="1924.5" y="797.15997" - id="tspan2326">₂</tspan></text> - </g> - <path + id="tspan2326">₂</tspan></text></g><path id="R_AcetoacetylACPsynthesis" d="m 1884.51,812.903 c 5.06,-0.402 5.93,-7.502 5.93,-7.502 M 1896.5,852 c 1.5,-35 11.36,-39.231 24,-39.408 m -47.5,0.251 53.28,-0.282 m -18.42,0.208 c 5.03,-0.525 5.3,-7.639 5.3,-7.639" stroke="#000000" - stroke-width="1.9665" /> - <text + stroke-width="1.9665" /><text id="text6997-5-1-8-3-7-7-3-7-7" fill="#000000" xml:space="preserve" @@ -3604,16 +3134,12 @@ letter-spacing="0em"><tspan x="1876.16" y="797.15997" - id="tspan2332">ACP</tspan></text> - <path + id="tspan2332">ACP</tspan></text><path id="F_AcetoacetylACPsynthesis" d="m 1925.33,814.458 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z m -33.93,-8.263 c -1.47,-5.595 -1.47,-5.595 -1.47,-5.595 l -1.11,5.65 1.24,-1.433 z m 23.04,0 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 73"> - <text + stroke-width="2.23952" /></g><g + id="Group 73"><text id="text6997-5-1-8-3-71-2-5-49" fill="#000000" xml:space="preserve" @@ -3624,13 +3150,11 @@ letter-spacing="0em"><tspan x="1777.2" y="865.32098" - id="tspan2337">MalCoA</tspan></text> - <path + id="tspan2337">MalCoA</tspan></text><path id="R_MCAT" d="m 1839.09,860.31 23.43,0.238 m -13,0.003 c 5.06,-0.384 6.22,-8.47 6.22,-8.47 m -10.11,8.511 c -4.92,1.031 -4.5,8.67 -4.5,8.67" stroke="#000000" - stroke-width="1.86971" /> - <text + stroke-width="1.86971" /><text id="text6997-5-1-8-3-7-7-3-7-2" fill="#000000" xml:space="preserve" @@ -3640,8 +3164,7 @@ letter-spacing="0em"><tspan x="1845.02" y="844.15997" - id="tspan2341">CoA</tspan></text> - <text + id="tspan2341">CoA</tspan></text><text id="text7967-8-1" fill="#000000" xml:space="preserve" @@ -3652,8 +3175,7 @@ letter-spacing="0em"><tspan x="1870.99" y="867.72498" - id="tspan2344">MalACP</tspan></text> - <text + id="tspan2344">MalACP</tspan></text><text id="text6997-5-1-8-3-71-2-5-43-4-1" fill="#000000" xml:space="preserve" @@ -3663,16 +3185,12 @@ letter-spacing="0em"><tspan x="1829.86" y="881.15997" - id="tspan2347">ACP</tspan></text> - <path + id="tspan2347">ACP</tspan></text><path id="F_MCAT" d="m 1861.27,862.358 c 5.84,-1.962 5.84,-1.962 5.84,-1.962 l -5.97,-1.524 1.54,1.688 z m -4.4,-9.457 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 79"> - <text + stroke-width="2.23952" /></g><g + id="Group 79"><text id="text7047" fill="#000000" xml:space="preserve" @@ -3682,10 +3200,8 @@ letter-spacing="0em"><tspan x="1645.3199" y="955.15997" - id="tspan2352">AcCoA</tspan></text> - <g - id="text7052"> - <text + id="tspan2352">AcCoA</tspan></text><g + id="text7052"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3698,8 +3214,7 @@ id="tspan2355">H</tspan><tspan x="1617.28" y="955.15997" - id="tspan2357">O</tspan></text> - <text + id="tspan2357">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3709,9 +3224,7 @@ id="text2363"><tspan x="1613.05" y="955.15997" - id="tspan2361">₂</tspan></text> - </g> - <text + id="tspan2361">₂</tspan></text></g><text id="text7078" fill="#000000" xml:space="preserve" @@ -3721,8 +3234,7 @@ letter-spacing="0em"><tspan x="1607.3199" y="920.15997" - id="tspan2366">CoA</tspan></text> - <text + id="tspan2366">CoA</tspan></text><text id="text7164" fill="#000000" xml:space="preserve" @@ -3733,21 +3245,16 @@ letter-spacing="0em"><tspan x="1529.08" y="940.64801" - id="tspan2369">AcAcCoA</tspan></text> - <path + id="tspan2369">AcAcCoA</tspan></text><path id="F_HMGCOAS" d="m 1619.32,928.248 -1.47,-5.596 -1.11,5.65 1.24,-1.433 z m 87.44,8.733 5.84,-1.962 -5.97,-1.524 1.54,1.688 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_HMGCOAS" d="m 1607,935.475 h 100.5 m -93.23,8.722 c 0,0 -2.66,-7.719 2.23,-8.722 5.05,-0.886 1.34,-7.755 1.34,-7.755 m 49.1,7.755 c -4.89,1.003 -4.47,8.43 -4.47,8.43" stroke="#000000" - stroke-width="1.77188" /> - </g> - <g - id="Group 72"> - <text + stroke-width="1.77188" /></g><g + id="Group 72"><text id="PalmCoA" fill="#000000" xml:space="preserve" @@ -3758,8 +3265,7 @@ letter-spacing="0em"><tspan x="2195.4099" y="739.547" - id="tspan2375">PalmCoA</tspan></text> - <text + id="tspan2375">PalmCoA</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-1-2" fill="#000000" xml:space="preserve" @@ -3769,8 +3275,7 @@ letter-spacing="0em"><tspan x="2242.3201" y="802.15997" - id="tspan2378">CoA</tspan></text> - <text + id="tspan2378">CoA</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-8-7" fill="#000000" xml:space="preserve" @@ -3780,8 +3285,7 @@ letter-spacing="0em"><tspan x="2247.5" y="761.15997" - id="tspan2381">AMP</tspan></text> - <text + id="tspan2381">AMP</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-2-5" transform="rotate(0.250513,-173384.82,514314.31)" fill="#000000" @@ -3792,8 +3296,7 @@ letter-spacing="0em"><tspan x="0" y="11.1602" - id="tspan2384">PPi</tspan></text> - <text + id="tspan2384">PPi</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-1-2-4" fill="#000000" xml:space="preserve" @@ -3803,18 +3306,15 @@ letter-spacing="0em"><tspan x="2242.27" y="788.15997" - id="tspan2387">ATP</tspan></text> - <path + id="tspan2387">ATP</tspan></text><path id="F_palmitateActivation" d="m 2238.71,758.266 c 5.73,-0.74 5.73,-0.74 5.73,-0.74 l -5.46,-1.827 1.26,1.419 z m 0.79,13.234 c 1.79,-0.5 3.5,-1.5 3.5,-1.5 l -4.29,-1.764 1.29,1.764 z m -6.33,-19.396 C 2231.34,747 2231.34,747 2231.34,747 l -1.34,5.247 1.52,-1.365 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_palmitateActivation" d="m 2239.79,757.019 c -5.7,-1.617 -8.64,3.967 -8.64,3.967 m 9.02,21.514 c 0,0 -8.71,0.811 -8.71,-5 0,0 0,-7.5 8.71,-7.5 m -8.71,25 c 1.17,4.019 8.71,2.811 8.71,2.811 m -8.71,5.189 v -52.878" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-5-1" fill="#000000" xml:space="preserve" @@ -3825,11 +3325,8 @@ letter-spacing="0em"><tspan x="2210.3701" y="817.547" - id="tspan2392">Palm</tspan></text> - </g> - <g - id="Group 76"> - <text + id="tspan2392">Palm</tspan></text></g><g + id="Group 76"><text id="text7967-8" fill="#000000" xml:space="preserve" @@ -3840,8 +3337,7 @@ letter-spacing="0em"><tspan x="1936.13" y="817.547" - id="tspan2396">AcAcACP</tspan></text> - <text + id="tspan2396">AcAcACP</tspan></text><text id="text6997-5-1-8-3-7-4-7" fill="#000000" xml:space="preserve" @@ -3851,10 +3347,8 @@ letter-spacing="0em"><tspan x="2096.1399" y="833.15997" - id="tspan2399">14 NADPH</tspan></text> - <g - id="text6997-5-1-8-3-7-7-9-3"> - <text + id="tspan2399">14 NADPH</tspan></text><g + id="text6997-5-1-8-3-7-7-9-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3864,8 +3358,7 @@ id="text2404"><tspan x="2022.37" y="794.15997" - id="tspan2402">14 NADP</tspan></text> - <text + id="tspan2402">14 NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3875,11 +3368,8 @@ id="text2408"><tspan x="2072.4199" y="794.15997" - id="tspan2406">⁺</tspan></text> - </g> - <g - id="text6997-5-1-8-3-71-5-6-17"> - <text + id="tspan2406">⁺</tspan></text></g><g + id="text6997-5-1-8-3-71-5-6-17"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3892,8 +3382,7 @@ id="tspan2411">6 H</tspan><tspan x="2201.29" y="794.15997" - id="tspan2413">O</tspan></text> - <text + id="tspan2413">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3903,11 +3392,8 @@ id="text2419"><tspan x="2197.0601" y="794.15997" - id="tspan2417">₂</tspan></text> - </g> - <g - id="text6997-5-1-8-3-71-5-7-3-5-8"> - <text + id="tspan2417">₂</tspan></text></g><g + id="text6997-5-1-8-3-71-5-7-3-5-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3917,8 +3403,7 @@ id="text2424"><tspan x="2134.48" y="794.15997" - id="tspan2422">6 CO</tspan></text> - <text + id="tspan2422">6 CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3928,9 +3413,7 @@ id="text2428"><tspan x="2162.51" y="794.15997" - id="tspan2426">₂</tspan></text> - </g> - <text + id="tspan2426">₂</tspan></text></g><text id="text7967-5-3" fill="#000000" xml:space="preserve" @@ -3940,8 +3423,7 @@ letter-spacing="0em"><tspan x="2033.48" y="833.15997" - id="tspan2431">6 MalACP</tspan></text> - <text + id="tspan2431">6 MalACP</tspan></text><text id="text6997-5-1-8-3-71-5-6-1-4" fill="#000000" xml:space="preserve" @@ -3951,15 +3433,12 @@ letter-spacing="0em"><tspan x="2088.48" y="794.15997" - id="tspan2434">7 ACP</tspan></text> - <path + id="tspan2434">7 ACP</tspan></text><path id="F_FA160ACPH" d="M 2194.58,804.595 C 2193.12,799 2193.12,799 2193.12,799 l -1.12,5.65 1.25,-1.433 z m -43.12,-0.5 C 2150,798.5 2150,798.5 2150,798.5 l -1.12,5.649 1.25,-1.432 z m -43.96,-0.878 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z m -52.5,0 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z m 145.46,10.961 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="text3083"> - <text + stroke-width="2.23952" /><g + id="text3083"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3969,8 +3448,7 @@ id="text2440"><tspan x="2171.21" y="833.15997" - id="tspan2438">14 H</tspan></text> - <text + id="tspan2438">14 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3980,17 +3458,12 @@ id="text2444"><tspan x="2196.5801" y="833.15997" - id="tspan2442">⁺</tspan></text> - </g> - <path + id="tspan2442">⁺</tspan></text></g><path id="R_FA160ACPH" d="m 2184,821.778 c 0,0 0.2,-8.126 5.05,-9.197 4.84,-0.867 3.61,-8.201 3.61,-8.201 m -177.16,8.073 c 0,0 37.79,0 62,0 m 123.44,0 c 0,0 -43.54,0 -71.44,0 m -27.5,0 c 4.8,-0.954 4.08,-9.019 4.08,-9.019 m -56.08,9.019 c 4.8,-0.954 3.58,-9.019 3.58,-9.019 m 92.66,8.832 c 4.84,-0.868 3.61,-8.201 3.61,-8.201 m -72.35,8.388 c -11.5,-0.187 -11.5,9.325 -11.5,9.325 m 11.5,-9.325 c 20.31,0 31.69,0 52,0 m 0,0 c -8.5,-0.187 -8.5,9.325 -8.5,9.325" stroke="#000000" - stroke-width="2.08132" /> - </g> - <g - id="Group 78"> - <text + stroke-width="2.08132" /></g><g + id="Group 78"><text id="text7122" fill="#000000" xml:space="preserve" @@ -4001,8 +3474,7 @@ letter-spacing="0em"><tspan x="1718.38" y="939.547" - id="tspan2449">HMGCoA</tspan></text> - <text + id="tspan2449">HMGCoA</tspan></text><text id="text7188" fill="#000000" xml:space="preserve" @@ -4012,8 +3484,7 @@ letter-spacing="0em"><tspan x="1883.1" y="954.15997" - id="tspan2452">3 ATP</tspan></text> - <text + id="tspan2452">3 ATP</tspan></text><text id="text7192" fill="#000000" xml:space="preserve" @@ -4023,8 +3494,7 @@ letter-spacing="0em"><tspan x="1792.3199" y="919.15997" - id="tspan2455">CoA</tspan></text> - <text + id="tspan2455">CoA</tspan></text><text id="text7214" fill="#000000" xml:space="preserve" @@ -4034,10 +3504,8 @@ letter-spacing="0em"><tspan x="1772.48" y="954.15997" - id="tspan2458">2 NADPH</tspan></text> - <g - id="text7222"> - <text + id="tspan2458">2 NADPH</tspan></text><g + id="text7222"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4047,8 +3515,7 @@ id="text2463"><tspan x="1823.21" y="919.15997" - id="tspan2461">2 NADP</tspan></text> - <text + id="tspan2461">2 NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4058,9 +3525,7 @@ id="text2467"><tspan x="1866.58" y="919.15997" - id="tspan2465">⁺</tspan></text> - </g> - <text + id="tspan2465">⁺</tspan></text></g><text id="text7230" fill="#000000" xml:space="preserve" @@ -4070,10 +3535,8 @@ letter-spacing="0em"><tspan x="1902.48" y="919.15997" - id="tspan2470">3 ADP</tspan></text> - <g - id="text7238"> - <text + id="tspan2470">3 ADP</tspan></text><g + id="text7238"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4083,8 +3546,7 @@ id="text2475"><tspan x="1940.49" y="919.15997" - id="tspan2473">CO</tspan></text> - <text + id="tspan2473">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4094,9 +3556,7 @@ id="text2479"><tspan x="1958.5" y="919.15997" - id="tspan2477">₂</tspan></text> - </g> - <text + id="tspan2477">₂</tspan></text></g><text id="text7246" fill="#000000" xml:space="preserve" @@ -4106,21 +3566,16 @@ letter-spacing="0em"><tspan x="1881.16" y="919.15997" - id="tspan2482">Pi</tspan></text> - <path + id="tspan2482">Pi</tspan></text><path id="F_DPMVD" d="m 1946.9,927.988 c -1.47,-5.596 -1.47,-5.596 -1.47,-5.596 l -1.11,5.65 1.24,-1.433 z m -23.44,-0.001 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z m -35.96,0 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z m -83,0.055 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 41.33,-0.054 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 104.44,9.104 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_DPMVD" d="m 1792,935.602 160,-0.176 m -96.86,0.205 c -7.95,0.876 -7.27,7.369 -7.27,7.369 m 58.88,-7.444 c -7.95,0.876 -7.27,7.369 -7.27,7.369 m -102.4,-7.434 c 8.33,-0.779 6.21,-7.369 6.21,-7.369 m 2.08,7.509 c -7.94,0.876 -7.26,7.369 -7.26,7.369 m 40.34,-7.618 c 7.87,-0.782 5.87,-7.382 5.87,-7.382 m 35.82,7.382 c 7.87,-0.782 5.87,-7.382 5.87,-7.382 m 30.31,7.382 c 7.86,-0.782 5.86,-7.382 5.86,-7.382 m 17.54,7.382 c 7.87,-0.782 5.87,-7.382 5.87,-7.382" stroke="#000000" - stroke-width="2.13327" /> - </g> - <g - id="Group 77"> - <text + stroke-width="2.13327" /></g><g + id="Group 77"><text id="text6997-5-1-8-3-7-7-3" fill="#000000" xml:space="preserve" @@ -4130,8 +3585,7 @@ letter-spacing="0em"><tspan x="2007.15" y="919.15997" - id="tspan2488">2 PPi</tspan></text> - <text + id="tspan2488">2 PPi</tspan></text><text id="text7967" fill="#000000" xml:space="preserve" @@ -4142,8 +3596,7 @@ letter-spacing="0em"><tspan x="2044.16" y="941.547" - id="tspan2491">fPP</tspan></text> - <text + id="tspan2491">fPP</tspan></text><text id="text6997-5-1-8-3-71-2-5-43" fill="#000000" xml:space="preserve" @@ -4153,8 +3606,7 @@ letter-spacing="0em"><tspan x="1995.47" y="955.15997" - id="tspan2494">2 ippPP</tspan></text> - <text + id="tspan2494">2 ippPP</tspan></text><text id="text7208" fill="#000000" xml:space="preserve" @@ -4165,21 +3617,16 @@ letter-spacing="0em"><tspan x="1959.3199" y="941.547" - id="tspan2497">ippPP</tspan></text> - <path + id="tspan2497">ippPP</tspan></text><path id="R_DMATT" d="m 2006.5,935.135 h 28.82 m -15.61,0.486 c -4.93,1.002 -4.33,8.145 -4.33,8.145 m 3.24,-8.618 c 4.94,-0.758 3.5,-6.89 3.5,-6.89" stroke="#000000" - stroke-width="1.73438" /> - <path + stroke-width="1.73438" /><path id="F_DMATT" d="m 2033.85,936.926 c 5.83,-1.963 5.83,-1.963 5.83,-1.963 l -5.96,-1.523 1.54,1.688 z m -10.54,-8.025 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 82"> - <text + stroke-width="2.23952" /></g><g + id="Group 82"><text id="text6997-5-1-8-3-7-4" fill="#000000" xml:space="preserve" @@ -4189,10 +3636,8 @@ letter-spacing="0em"><tspan x="2188.1399" y="957.15997" - id="tspan2503">13 NADPH</tspan></text> - <g - id="text6997-5-1-8-3-71-2-7"> - <text + id="tspan2503">13 NADPH</tspan></text><g + id="text6997-5-1-8-3-71-2-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4202,8 +3647,7 @@ id="text2508"><tspan x="2171.1799" y="957.15997" - id="tspan2506">2</tspan></text> - <text + id="tspan2506">2</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4213,11 +3657,8 @@ id="text2512"><tspan x="2145.1399" y="957.15997" - id="tspan2510">10 O</tspan></text> - </g> - <g - id="text6997-5-1-8-3-7-7-9"> - <text + id="tspan2510">10 O</tspan></text></g><g + id="text6997-5-1-8-3-7-7-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4227,8 +3668,7 @@ id="text2517"><tspan x="2267.3701" y="917.15997" - id="tspan2515">13 NADP</tspan></text> - <text + id="tspan2515">13 NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4238,9 +3678,7 @@ id="text2521"><tspan x="2317.4199" y="917.15997" - id="tspan2519">⁺</tspan></text> - </g> - <text + id="tspan2519">⁺</tspan></text></g><text id="text6997-5-1-8-3-71-5-6" fill="#000000" xml:space="preserve" @@ -4250,8 +3688,7 @@ letter-spacing="0em"><tspan x="2077.1499" y="917.15997" - id="tspan2524">2 PPi</tspan></text> - <text + id="tspan2524">2 PPi</tspan></text><text id="text6997-5-1-8-3-71-5-7-36" fill="#000000" xml:space="preserve" @@ -4261,10 +3698,8 @@ letter-spacing="0em"><tspan x="2118.1399" y="917.15997" - id="tspan2527">formate</tspan></text> - <g - id="text6997-5-1-8-3-71-5-7-3-5"> - <text + id="tspan2527">formate</tspan></text><g + id="text6997-5-1-8-3-71-5-7-3-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4274,8 +3709,7 @@ id="text2532"><tspan x="2171.48" y="917.15997" - id="tspan2530">2 CO</tspan></text> - <text + id="tspan2530">2 CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4285,9 +3719,7 @@ id="text2536"><tspan x="2199.51" y="917.15997" - id="tspan2534">₂</tspan></text> - </g> - <text + id="tspan2534">₂</tspan></text></g><text id="text7967-0" fill="#000000" xml:space="preserve" @@ -4298,8 +3730,7 @@ letter-spacing="0em"><tspan x="2306.21" y="940.547" - id="tspan2539">Chol</tspan></text> - <text + id="tspan2539">Chol</tspan></text><text id="text7967-5" fill="#000000" xml:space="preserve" @@ -4309,10 +3740,8 @@ letter-spacing="0em"><tspan x="2255.3301" y="957.15997" - id="tspan2542">fPP</tspan></text> - <g - id="text6997-5-1-8-3-71-5-6-1"> - <text + id="tspan2542">fPP</tspan></text><g + id="text6997-5-1-8-3-71-5-6-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4325,8 +3754,7 @@ id="tspan2545">15 H</tspan><tspan x="2245.6299" y="917.15997" - id="tspan2547">O</tspan></text> - <text + id="tspan2547">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4336,21 +3764,16 @@ id="text2554"><tspan x="2241.3999" y="917.15997" - id="tspan2551">₂</tspan></text> - </g> - <path + id="tspan2551">₂</tspan></text></g><path id="F_DSMSTOLR" d="m 2296.59,937.274 c 5.84,-1.962 5.84,-1.962 5.84,-1.962 l -5.97,-1.524 1.54,1.689 z m -199.01,-11.328 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 L 2095,926 l 1.25,-1.433 z m 46.25,0.528 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 46.13,0 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 48.87,0 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 50.67,0.026 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_DSMSTOLR" d="m 2132.5,935.635 c 11,-0.017 10,-9.468 10,-9.468 m -55.5,9.327 c 9.5,0 9.5,-9.328 9.5,-9.328 m 186.35,9.428 c 7.4,-0.998 5.52,-9.427 5.52,-9.427 m -20,9.327 c -7.48,1.119 -6.84,9.411 -6.84,9.411 m -31.03,-9.338 c 7.4,-0.998 7,-9.4 7,-9.4 m -60.3,9.4 c 11.3,-0.018 11.3,-9.4 11.3,-9.4 m -21.8,9.327 c -7.48,1.119 -6.84,9.411 -6.84,9.411 m -35.72,-9.316 c -7.47,1.119 -6.83,9.411 -6.83,9.411 m -43.81,-9.506 h 151.27 m 74.23,0.015 -74.23,-0.015 m 0,0 c -6.84,0 -6.84,9.411 -6.84,9.411" stroke="#000000" - stroke-width="2.08645" /> - <g - id="text3145"> - <text + stroke-width="2.08645" /><g + id="text3145"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4360,8 +3783,7 @@ id="text2561"><tspan x="2103.21" y="957.15997" - id="tspan2559">16 H</tspan></text> - <text + id="tspan2559">16 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4371,10 +3793,7 @@ id="text2565"><tspan x="2128.5801" y="957.15997" - id="tspan2563">⁺</tspan></text> - </g> - </g> - <text + id="tspan2563">⁺</tspan></text></g></g><text id="text6997-5-1-8" fill="#000000" xml:space="preserve" @@ -4385,10 +3804,8 @@ letter-spacing="0em"><tspan x="1429" y="854.203" - id="tspan2569">AcCoA</tspan></text> - <g - id="Group 80"> - <text + id="tspan2569">AcCoA</tspan></text><g + id="Group 80"><text id="text7122_2" fill="#000000" xml:space="preserve" @@ -4399,29 +3816,23 @@ letter-spacing="0em"><tspan x="1716.38" y="1068.55" - id="tspan2572">HMGCoA</tspan></text> - <path + id="tspan2572">HMGCoA</tspan></text><path id="F_HMGCOAtm" d="M 1746.49,951.86 C 1744.6,946 1744.6,946 1744.6,946 l -1.6,5.942 1.71,-1.516 z" stroke="#000000" - stroke-width="2.66667" /> - <path + stroke-width="2.66667" /><path id="R_HMGCOAtm" d="M 1745,1047 V 951" stroke="#000000" - stroke-width="1.40903" /> - <path + stroke-width="1.40903" /><path id="B_HMGCOAtm" d="m 1743,1047.15 c 2.45,3.85 2.45,3.85 2.45,3.85 l 1.55,-4 -1.89,1.06 z" stroke="#000000" - stroke-width="2.66667" /> - </g> - <g + stroke-width="2.66667" /></g><g id="Group 80-3" transform="translate(-286.84663,-79.989336)" inkscape:transform-center-x="-114.47137" - inkscape:transform-center-y="-3.5938632"> - <text + inkscape:transform-center-y="-3.5938632"><text id="text7122_2-6" fill="#000000" xml:space="preserve" @@ -4438,8 +3849,7 @@ y="1054.1113"><tspan x="1721.1489" y="1054.1113" - id="tspan2572-7">aCarn</tspan></tspan></text> - <text + id="tspan2572-7">aCarn</tspan></tspan></text><text id="text7122_2-6-2" fill="#000000" xml:space="preserve" @@ -4456,29 +3866,22 @@ y="1146.1766"><tspan x="1722.4319" y="1146.1766" - id="tspan2572-7-0">aCarn</tspan></tspan></text> - <path + id="tspan2572-7-0">aCarn</tspan></tspan></text><path style="opacity:0;fill:#1a1a1a;fill-opacity:0.891118;stroke:#e60000;stroke-width:0.999862" d="m 1784.874,1123.0143 14.9467,12.9971 21.8875,-0.1614 10.0512,-16.4468" - 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</g> - <g - id="Group 81"> - <text + id="path5" /></g><g + id="Group 81"><text id="text7096" fill="#000000" xml:space="preserve" @@ -4488,8 +3891,7 @@ letter-spacing="0em"><tspan x="1543.3199" y="867.15997" - id="tspan2579">AcCoA</tspan></text> - <text + id="tspan2579">AcCoA</tspan></text><text id="text7126" fill="#000000" xml:space="preserve" @@ -4499,40 +3901,30 @@ letter-spacing="0em"><tspan x="1524.3199" y="903.15997" - id="tspan2582">CoA</tspan></text> - <path + id="tspan2582">CoA</tspan></text><path id="F_ACACT1r" d="m 1544.57,885.774 c -4.71,3.345 -4.71,3.345 -4.71,3.345 l 2.77,-5.046 0.04,1.9 z m 41.93,33.726 c 1.5,2.797 1.5,6.5 1.5,6.5 l -3.99,-3.703 2.16,-0.551 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_ACACT1r" d="m 1543.25,885.667 c 0,0 6.79,-3.904 4.26,-7.167 -2.54,-3.263 4.42,-9 4.42,-9 m -66.93,-16 c 0,0 68,8.5 100.5,68" stroke="#000000" - stroke-width="1.91333" /> - </g> - </g> - </g> - <g + stroke-width="1.91333" /></g></g></g><g id="path_ammonia" - transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"><g id="g30" inkscape:label="box_ammonia" - transform="translate(14.054909,10.018211)"> - <path + transform="translate(14.054909,10.018211)"><path id="Rectangle 3_6" d="m 1858,1185 v -63 c 0,-6.63 -5.37,-12 -12,-12 H 1819.24 1489 c -6.63,0 -12,5.37 -12,12 v 63 c 0,6.63 5.37,12 12,12 h 357 c 6.63,0 12,-5.37 12,-12 z" fill="#c19c91" - fill-opacity="0.1" /> - <path + fill-opacity="0.1" /><path id="Rectangle 2_6" d="m 1674.6136,1096.2271 h 161.9529 c 6.63,0 9.4335,6.1429 9.4335,12.7729 v 63.5 c 0,6.63 -5.37,12 -12,12 h -357 c -6.63,0 -12,-5.37 -12,-12 V 1109 c 0,-6.63 5.37,-12 12,-12 h 12.5" stroke="#c19c91" stroke-width="4" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_6" fill="#000000" xml:space="preserve" @@ -4543,21 +3935,15 @@ letter-spacing="0em"><tspan x="1497" y="1103.4301" - id="tspan742">Ammonia detox </tspan></text> - <circle + id="tspan742">Ammonia detox </tspan></text><circle id="Ellipse 1_6" cx="1675.0625" cy="1097" r="6" - fill="#c19c91" /> - </g> - <g - id="Group 26"> - <g - id="Group 157"> - <g - id="text6979-5-4-1-7-9-30-5-8-5-57-7-5-3"> - <text + fill="#c19c91" /></g><g + id="Group 26"><g + id="Group 157"><g + id="text6979-5-4-1-7-9-30-5-8-5-57-7-5-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4570,8 +3956,7 @@ y="9.3660402"><tspan x="1409.2559" y="992.91302" - id="tspan2589">3</tspan></text> - <text + id="tspan2589">3</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4584,31 +3969,25 @@ y="9.3660402"><tspan x="1386.1259" y="992.91302" - id="tspan2593">NH</tspan></text> - </g> - <path + id="tspan2593">NH</tspan></text></g><path id="B_NH4tm" fill-rule="evenodd" clip-rule="evenodd" d="m 1403.2217,1003.3926 -1.64,-5.36703 -1.76,5.32803 1.71,-1.317 z" stroke="#000000" stroke-width="2.61244" - 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stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-3-65-5-3-5-8-9-7-6-6-6-7-7" transform="rotate(0.813633,-137520.66,71342.096)" fill="#000000" @@ -7121,10 +6161,8 @@ letter-spacing="0em"><tspan x="0.48828101" y="11.1602" - id="tspan3012">NADPH</tspan></text> - <g - id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-2-8"> - <text + id="tspan3012">NADPH</tspan></text><g + id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-2-8"><text transform="rotate(0.777998,-143424.05,71247.391)" fill="#000000" xml:space="preserve" @@ -7135,8 +6173,7 @@ id="text3017"><tspan x="0.221874" y="11.1602" - id="tspan3015">NADP</tspan></text> - <text + id="tspan3015">NADP</tspan></text><text transform="rotate(0.777998,-143424.05,71247.391)" fill="#000000" xml:space="preserve" @@ -7147,11 +6184,8 @@ id="text3021"><tspan x="33.573399" y="11.1602" - id="tspan3019">⁺</tspan></text> - </g> - <g - id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-5-5-1-8"> - <text + id="tspan3019">⁺</tspan></text></g><g + id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-5-5-1-8"><text transform="rotate(0.0309296,-3633941.1,2153828.2)" fill="#000000" xml:space="preserve" @@ -7162,8 +6196,7 @@ id="text3026"><tspan x="0.0617189" y="11.1602" - id="tspan3024">H</tspan></text> - <text + id="tspan3024">H</tspan></text><text transform="rotate(0.0309296,-3633941.1,2153828.2)" fill="#000000" xml:space="preserve" @@ -7174,9 +6207,7 @@ id="text3030"><tspan x="8.7335901" y="11.1602" - id="tspan3028">⁺</tspan></text> - </g> - <text + id="tspan3028">⁺</tspan></text></g><text id="text7967-0-3-65-5-3-5-8-9-7-3" fill="#000000" xml:space="preserve" @@ -7186,10 +6217,8 @@ letter-spacing="0em"><tspan x="873.35901" y="1896.21" - id="tspan3033">THF</tspan></text> - <g - id="text7967-0-3-65-1-2-4-9-6-3-1"> - <text + id="tspan3033">THF</tspan></text><g + id="text7967-0-3-65-1-2-4-9-6-3-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7202,8 +6231,7 @@ id="tspan3036">H</tspan><tspan x="887.35498" y="1919.3" - id="tspan3038">O</tspan></text> - <text + id="tspan3038">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7213,11 +6241,8 @@ id="text3044"><tspan x="883.13098" y="1919.3" - id="tspan3042">₂</tspan></text> - </g> - <g - id="text6979-5-4-1-7-9-30-5-8-5-5"> - <text + id="tspan3042">₂</tspan></text></g><g + id="text6979-5-4-1-7-9-30-5-8-5-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7228,8 +6253,7 @@ id="text3049"><tspan x="1911.3199" y="2093.55" - id="tspan3047">CO</tspan></text> - <text + id="tspan3047">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7240,11 +6264,8 @@ id="text3053"><tspan x="1935.34" y="2093.55" - id="tspan3051">₂</tspan></text> - </g> - <g - id="text6979-5-4-1-7-9-30-93-0-9-3"> - <text + id="tspan3051">₂</tspan></text></g><g + id="text6979-5-4-1-7-9-30-93-0-9-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7255,8 +6276,7 @@ id="text3058"><tspan x="1801.3199" y="2093.55" - id="tspan3056">CO</tspan></text> - <text + id="tspan3056">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7267,30 +6287,24 @@ id="text3062"><tspan x="1825.34" y="2093.55" - id="tspan3060">₂</tspan></text> - </g> - <path + id="tspan3060">₂</tspan></text></g><path id="B_CO2tm" fill-rule="evenodd" clip-rule="evenodd" d="m 1897.02,2091.7 c 9.22,-2.82 9.22,-2.82 9.22,-2.82 l -9.15,-3.02 2.26,2.95 z" stroke="#000000" - stroke-width="2.61244" /> - <path + stroke-width="2.61244" /><path id="R_CO2tm" d="m 1841.89,2089.37 h 58.85" stroke="#000000" - stroke-width="1.77153" /> - <path + stroke-width="1.77153" /><path id="F_CO2tm" fill-rule="evenodd" clip-rule="evenodd" d="m 1845.36,2085.75 c -8.78,3.96 -8.78,3.96 -8.78,3.96 l 9.46,1.85 -2.62,-2.64 z" stroke="#000000" - stroke-width="2.61244" /> - <g - id="Group 53"> - <text + stroke-width="2.61244" /><g + id="Group 53"><text id="text7967-0-3-6-2-7-4-34-0-4-2-9-11" transform="translate(1682.06,1623.15)" fill="#000000" @@ -7302,8 +6316,7 @@ letter-spacing="0em"><tspan x="0.375" y="14.5469" - id="tspan3068">NADH</tspan></text> - <text + id="tspan3068">NADH</tspan></text><text id="text7967-0-3-6-2-7-4-34-0-4-2-9-62" transform="translate(1916.06,1623.18)" fill="#000000" @@ -7315,10 +6328,8 @@ letter-spacing="0em"><tspan x="0.0390625" y="14.5469" - id="tspan3071">NADPH</tspan></text> - <g - id="text7009-4-5"> - <text + id="tspan3071">NADPH</tspan></text><g + id="text7009-4-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7329,8 +6340,7 @@ id="text3076"><tspan x="1723.02" y="1614.55" - id="tspan3074">NADP</tspan></text> - <text + id="tspan3074">NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7341,11 +6351,8 @@ id="text3080"><tspan x="1768.38" y="1614.55" - id="tspan3078">⁺</tspan></text> - </g> - <g - id="text7009-4-5-0"> - <text + id="tspan3078">⁺</tspan></text></g><g + id="text7009-4-5-0"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7356,8 +6363,7 @@ id="text3085"><tspan x="1791.35" y="1608.55" - id="tspan3083">NAD</tspan></text> - <text + id="tspan3083">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7368,16 +6374,12 @@ id="text3089"><tspan x="1826.04" y="1608.55" - id="tspan3087">⁺</tspan></text> - </g> - <path + id="tspan3087">⁺</tspan></text></g><path id="F_THD1m" d="m 1902.98,1635.71 c 9.66,-3.1 9.66,-3.1 9.66,-3.1 l -9.8,-2.65 2.5,2.82 z m -89.98,-18.21 -3,-4.5 -0.5,5.5 2,-1.5 z m 38,0 -2,-4 -2,5 2.5,-1.5 z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="text7009-4-5-0-8"> - <text + stroke-width="2.23952" /><g + id="text7009-4-5-0-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7388,8 +6390,7 @@ id="text3095"><tspan x="1843.42" y="1608.55" - id="tspan3093">H</tspan></text> - <text + id="tspan3093">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7400,16 +6401,12 @@ id="text3099"><tspan x="1854.98" y="1608.55" - id="tspan3097">⁺</tspan></text> - </g> - <path + id="tspan3097">⁺</tspan></text></g><path id="R_THD1m" d="M 1905.5,1632.5 H 1732 m 72,0 c 12,0 7.5,-14.74 7.5,-14.74 m -66.5,0 c -5.5,14.74 11,14.74 11,14.74 m 82,0 c 13.5,0 11,-14.74 11,-14.74 m 37,14.74 c -5,15 14,22 14,22" stroke="#000000" - stroke-width="2.02293" /> - <g - id="text7009-4-5-0-8-2"> - <text + stroke-width="2.02293" /><g + id="text7009-4-5-0-8-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7419,8 +6416,7 @@ id="text3105"><tspan x="1904.0601" y="1661.16" - id="tspan3103">H</tspan></text> - <text + id="tspan3103">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7430,14 +6426,9 @@ id="text3109"><tspan x="1912.73" y="1661.16" - id="tspan3107">⁺</tspan></text> - </g> - </g> - <g - id="Group 51"> - <g - id="text7967-0-3-9-1-34"> - <text + id="tspan3107">⁺</tspan></text></g></g><g + id="Group 51"><g + id="text7967-0-3-9-1-34"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7451,8 +6442,7 @@ id="tspan3113">H</tspan><tspan x="1556.2" y="1312.55" - id="tspan3115">O</tspan></text> - <text + id="tspan3115">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7466,11 +6456,8 @@ id="tspan3119">₂</tspan><tspan x="1568.65" y="1312.55" - id="tspan3121">₂</tspan></text> - </g> - <g - id="text7967-0-3-9-1-8-46"> - <text + id="tspan3121">₂</tspan></text></g><g + id="text7967-0-3-9-1-8-46"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7484,8 +6471,7 @@ id="tspan3126">2 H</tspan><tspan x="1804.05" y="1312.55" - id="tspan3128">O</tspan></text> - <text + id="tspan3128">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7496,9 +6482,7 @@ id="text3134"><tspan x="1798.42" y="1312.55" - id="tspan3132">₂</tspan></text> - </g> - <text + id="tspan3132">₂</tspan></text></g><text id="text7967-0-3-2-6-6-4-4-3-5" fill="#000000" xml:space="preserve" @@ -7509,10 +6493,8 @@ letter-spacing="0em"><tspan x="1584.48" y="1289.55" - id="tspan3137">2 GSH</tspan></text> - <g - id="text7967-0-3-0-0-3"> - <text + id="tspan3137">2 GSH</tspan></text><g + id="text7967-0-3-0-0-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7523,8 +6505,7 @@ id="text3142"><tspan x="1407.36" y="1309.55" - id="tspan3140">O</tspan></text> - <text + id="tspan3140">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7535,8 +6516,7 @@ id="text3146"><tspan x="1419.8101" y="1309.55" - id="tspan3144">₂</tspan></text> - <text + id="tspan3144">₂</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7547,11 +6527,8 @@ id="text3150"><tspan x="1425.4399" y="1309.55" - id="tspan3148">⁻</tspan></text> - </g> - <g - id="text7967-0-3-0-1-1"> - <text + id="tspan3148">⁻</tspan></text></g><g + id="text7967-0-3-0-1-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7561,8 +6538,7 @@ id="text3155"><tspan x="1437.15" y="1283.16" - id="tspan3153">O</tspan></text> - <text + id="tspan3153">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7572,8 +6548,7 @@ id="text3159"><tspan x="1446.49" y="1283.16" - id="tspan3157">₂</tspan></text> - <text + id="tspan3157">₂</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7583,11 +6558,8 @@ id="text3163"><tspan x="1450.72" y="1283.16" - id="tspan3161">⁻</tspan></text> - </g> - <g - id="text7967-0-3-9-1-7-4"> - <text + id="tspan3161">⁻</tspan></text></g><g + id="text7967-0-3-9-1-7-4"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7597,8 +6569,7 @@ id="text3168"><tspan x="1467.1899" y="1286.16" - id="tspan3166">2 H</tspan></text> - <text + id="tspan3166">2 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7608,11 +6579,8 @@ id="text3172"><tspan x="1485.88" y="1286.16" - id="tspan3170">⁺</tspan></text> - </g> - <g - id="text7967-0-3-9-1-2-15"> - <text + id="tspan3170">⁺</tspan></text></g><g + id="text7967-0-3-9-1-2-15"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7622,8 +6590,7 @@ id="text3177"><tspan x="1508.46" y="1278.16" - id="tspan3175">O</tspan></text> - <text + id="tspan3175">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7633,19 +6600,15 @@ id="text3181"><tspan x="1517.8" y="1278.16" - id="tspan3179">₂</tspan></text> - </g> - <path + id="tspan3179">₂</tspan></text></g><path id="R_SPODMm" d="m 1504.5,1307.26 c 7.98,-2.18 7.31,-18.44 7.31,-18.44 m 14.76,18.37 -95.57,-0.33 m 45.18,-18.57 c -2.88,10.71 5.2,19.62 5.2,19.62 m -38.17,-20.71 c -4.05,7.37 3.39,20.62 3.39,20.62" stroke="#000000" - stroke-width="2.32897" /> - <path + stroke-width="2.32897" /><path id="R_GTHPm" d="M 1761.5,1306.86 H 1577 m 138,0 c 26,0 26,-13.36 26,-13.36 m -133,0 c 0,13.36 19.5,13.36 19.5,13.36" stroke="#000000" - stroke-width="2.59831" /> - <text + stroke-width="2.59831" /><text id="text7967-0-3-2-6-6-4-4-3-8-2" fill="#000000" xml:space="preserve" @@ -7656,25 +6619,20 @@ letter-spacing="0em"><tspan x="1717.38" y="1284.55" - id="tspan3186">GSSG</tspan></text> - <path + id="tspan3186">GSSG</tspan></text><path id="F_GTHPm" d="m 1759.94,1309.76 c 9.66,-3.1 9.66,-3.1 9.66,-3.1 l -9.8,-2.65 2.5,2.82 z m -16.61,-14.76 -3,-6.5 -1.5,6.5 1.67,-1 z" stroke="#000000" - stroke-width="1.90098" /> - <g - id="Group 158"> - <path + stroke-width="1.90098" /><g + id="Group 158"><path id="R_GDRm" d="M 1619.5,1274.5 V 1254 c 0,0 26.1,0.03 34.5,0 m 84.37,17 v -17 c 0,0 -46.34,-0.12 -84.37,0 m 52.5,-0.05 c 14.5,0.02 14.5,9.05 14.5,9.05 m -28,0 c 0,-9.06 -17.5,-9.05 -17.5,-9.05 M 1654,1254 c -16.5,0.01 -16.5,9.5 -16.5,9.5" stroke="#000000" - stroke-width="2.22804" /> - <path + stroke-width="2.22804" /><path id="R_GTHOm" d="m 1609,1270.5 v -24.25 c 0,0 65.58,0.23 100.5,0 m 37.5,24.25 v -24.25 c 0,0 -28.63,-0.06 -37.5,0 m -28.5,-0.22 c 17,-0.11 17,-9.53 17,-9.53 m -73,0 c 0,9.7 23.06,9.75 23.06,9.75 m 61.44,0 c 21.5,0.17 21.5,-9.75 21.5,-9.75" stroke="#000000" - stroke-width="2.53679" /> - <text + stroke-width="2.53679" /><text id="text7967-0-3-2-6-6-4-4-3-8-7-4" fill="#000000" xml:space="preserve" @@ -7684,10 +6642,8 @@ letter-spacing="0em"><tspan x="1674.49" y="1273.16" - id="tspan3192">NADH</tspan></text> - <g - id="text7967-0-3-2-6-6-4-4-3-8-7-4_2"> - <text + id="tspan3192">NADH</tspan></text><g + id="text7967-0-3-2-6-6-4-4-3-8-7-4_2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7697,8 +6653,7 @@ id="text3197"><tspan x="1717.0601" y="1273.16" - id="tspan3195">H</tspan></text> - <text + id="tspan3195">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7708,11 +6663,8 @@ id="text3201"><tspan x="1725.73" y="1273.16" - 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id="tspan3555">H</tspan></text> - <text + id="tspan3555">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -8905,9 +7679,7 @@ id="text3561"><tspan x="745.41302" y="1993.55" - id="tspan3559">⁺</tspan></text> - </g> - <text + id="tspan3559">⁺</tspan></text></g><text id="text7967-0-3-9-1-2-1-3-75" fill="#000000" xml:space="preserve" @@ -8917,10 +7689,8 @@ letter-spacing="0em"><tspan x="1223.33" y="1009.16" - id="tspan3564">Mal</tspan></text> - <g - id="text3174"> - <text + id="tspan3564">Mal</tspan></text><g + id="text3174"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -8930,8 +7700,7 @@ id="text3569"><tspan x="1279.0601" y="1009.16" - id="tspan3567">H</tspan></text> - <text + id="tspan3567">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -8941,11 +7710,8 @@ id="text3573"><tspan x="1287.73" y="1009.16" - id="tspan3571">⁺</tspan></text> - </g> - <g - id="Group 60"> - <text + id="tspan3571">⁺</tspan></text></g><g + id="Group 60"><text id="text6991" fill="#000000" xml:space="preserve" @@ -8956,8 +7722,7 @@ letter-spacing="0em"><tspan x="1079.27" y="1435.09" - id="tspan3576">OAA</tspan></text> - <text + id="tspan3576">OAA</tspan></text><text id="text7039" fill="#000000" xml:space="preserve" @@ -8968,8 +7733,7 @@ letter-spacing="0em"><tspan x="1152.33" y="1362.55" - id="tspan3579">Cit</tspan></text> - <text + id="tspan3579">Cit</tspan></text><text id="text7069" fill="#000000" xml:space="preserve" @@ -8982,8 +7746,7 @@ y="-3.5572813"><tspan x="1266.6304" y="1335.9928" - id="tspan3582">Iso</tspan></text> - <text + id="tspan3582">Iso</tspan></text><text id="AKG" fill="#000000" xml:space="preserve" @@ -8994,10 +7757,8 @@ letter-spacing="0em"><tspan x="1423.21" y="1445.55" - id="tspan3585">AKG</tspan></text> - <g - id="text6973-9"> - <text + id="tspan3585">AKG</tspan></text><g + id="text6973-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9007,8 +7768,7 @@ id="text3590"><tspan x="1320.22" y="1298.16" - id="tspan3588">NADP</tspan></text> - <text + id="tspan3588">NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9018,9 +7778,7 @@ id="text3594"><tspan x="1353.5699" y="1298.16" - id="tspan3592">⁺</tspan></text> - </g> - <text + id="tspan3592">⁺</tspan></text></g><text id="AKG-2" fill="#000000" xml:space="preserve" @@ -9031,8 +7789,7 @@ letter-spacing="0em"><tspan x="1373.3199" y="1598.55" - id="tspan3597">SuCoA</tspan></text> - <text + id="tspan3597">SuCoA</tspan></text><text id="AKG-2-0" fill="#000000" xml:space="preserve" @@ -9043,8 +7800,7 @@ letter-spacing="0em"><tspan x="1257.37" y="1655.55" - id="tspan3600">Succ</tspan></text> - <text + id="tspan3600">Succ</tspan></text><text id="AKG-2-0-6-0" fill="#000000" xml:space="preserve" @@ -9055,8 +7811,7 @@ letter-spacing="0em"><tspan x="1128.72" y="1625.23" - id="tspan3603">Fum</tspan></text> - <text + id="tspan3603">Fum</tspan></text><text id="AKG-2-0-6-5" fill="#000000" xml:space="preserve" @@ -9067,13 +7822,11 @@ letter-spacing="0em"><tspan x="1083.16" y="1545.55" - id="tspan3606">Mal</tspan></text> - <path + id="tspan3606">Mal</tspan></text><path id="R_ICDHym" d="m 1310,1331 c 9.9,0.42 19.05,1.64 27.54,3.5 m 103.46,85 c -7.8,-11.9 -18.26,-29.85 -34.57,-46.5 m 46.49,23.96 c -4.63,2.79 -10.28,3.88 -15.79,3.06 -5.51,-0.82 -10.46,-3.5 -13.81,-7.47 M 1327.5,1309 c 0,0 -6,22.88 10.04,25.5 m 0,0 c 20.92,4.59 37.75,13.09 51.46,23.25 m 17.43,15.25 c 12.68,14.5 32.07,3 32.07,3 m -32.07,-3 c -5.18,-5.29 -10.96,-10.46 -17.43,-15.25 m 0,0 c 15.5,13.31 32,-4.75 32,-4.75" stroke="#000000" - stroke-width="2.00254" /> - <text + stroke-width="2.00254" /><text id="text14326" fill="#000000" xml:space="preserve" @@ -9083,10 +7836,8 @@ letter-spacing="0em"><tspan x="1210.33" y="1685.16" - id="tspan3610">FAD</tspan></text> - <g - id="text14330"> - <text + id="tspan3610">FAD</tspan></text><g + id="text14330"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9096,8 +7847,7 @@ id="text3615"><tspan x="1162.49" y="1675.16" - id="tspan3613">FADH</tspan></text> - <text + id="tspan3613">FADH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9107,11 +7857,8 @@ id="text3619"><tspan x="1194.5" y="1675.16" - id="tspan3617">₂</tspan></text> - </g> - <g - id="text6973-9-0-3-2"> - <text + id="tspan3617">₂</tspan></text></g><g + id="text6973-9-0-3-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9121,8 +7868,7 @@ id="text3624"><tspan x="1109.22" y="1506.16" - id="tspan3622">NAD</tspan></text> - <text + id="tspan3622">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9132,16 +7878,12 @@ id="text3628"><tspan x="1134.5699" y="1506.16" - id="tspan3626">⁺</tspan></text> - </g> - <path + id="tspan3626">⁺</tspan></text></g><path id="R_CSm" d="m 1073.5,1360 18,6.5 c 0,0 3.52,-3.89 7,-3 4.15,1.06 7,9 7,9 l 23.56,9.41 m -19.32,29.36 c 7.05,-16.22 17.97,-31.01 32.01,-43.34 m -12.95,38.85 c -2.27,-1.33 -4.07,-3.28 -5.18,-5.65 -1.12,-2.36 -1.51,-5.05 -1.13,-7.74 0.39,-2.7 1.52,-5.3 3.29,-7.52 1.76,-2.22 4.08,-3.96 6.69,-5.04 2.62,-1.07 5.43,-1.43 8.11,-1.04 2.68,0.4 5.14,1.53 7.08,3.27" stroke="#000000" - stroke-width="2.25" /> - <g - id="text6997-5-9-4-3"> - <text + stroke-width="2.25" /><g + id="text6997-5-9-4-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9154,8 +7896,7 @@ id="tspan3632">H</tspan><tspan x="1142.76" y="1415.59" - id="tspan3634">O</tspan></text> - <text + id="tspan3634">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9165,13 +7906,10 @@ id="text3640"><tspan x="1138.54" y="1415.59" - id="tspan3638">₂</tspan></text> - </g> - <g + id="tspan3638">₂</tspan></text></g><g id="text6997-5-9-4-3-2" style="display:inline" - transform="translate(-244.27793,292.80999)"> - <text + transform="translate(-244.27793,292.80999)"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9184,8 +7922,7 @@ id="tspan3632-9">H</tspan><tspan x="1142.76" y="1415.59" - id="tspan3634-7">O</tspan></text> - <text + id="tspan3634-7">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9195,13 +7932,10 @@ id="text3640-3"><tspan x="1138.54" y="1415.59" - id="tspan3638-6">₂</tspan></text> - </g> - <g + id="tspan3638-6">₂</tspan></text></g><g id="text6997-5-9-4-3-2-2" style="display:inline" - transform="translate(-178.80515,232.63306)"> - <text + transform="translate(-178.80515,232.63306)"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9214,8 +7948,7 @@ id="tspan3632-9-6">H</tspan><tspan x="1142.76" y="1415.59" - id="tspan3634-7-1">O</tspan></text> - <text + id="tspan3634-7-1">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9225,13 +7958,10 @@ id="text3640-3-5"><tspan x="1138.54" y="1415.59" - id="tspan3638-6-5">₂</tspan></text> - </g> - <g + id="tspan3638-6-5">₂</tspan></text></g><g id="text6997-5-9-4-3-2-2-4" style="display:inline" - transform="translate(-240.27576,233.49328)"> - <text + transform="translate(-240.27576,233.49328)"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9244,8 +7974,7 @@ id="tspan3632-9-6-6">H</tspan><tspan x="1142.76" y="1415.59" - id="tspan3634-7-1-5">O</tspan></text> - <text + id="tspan3634-7-1-5">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9255,8 +7984,7 @@ id="text3640-3-5-6"><tspan x="1138.54" y="1415.59" - id="tspan3638-6-5-9">₂</tspan></text> - <text + id="tspan3638-6-5-9">₂</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre;display:inline" @@ -9268,9 +7996,7 @@ y="-0.11870071"><tspan x="1151.4916" y="1415.4713" - id="tspan3638-6-5-9-7">₂</tspan></text> - </g> - <text + id="tspan3638-6-5-9-7">₂</tspan></text></g><text id="text6997-5-9-4-3-6" fill="#000000" xml:space="preserve" @@ -9280,27 +8006,22 @@ letter-spacing="0em"><tspan x="1153.8199" y="1388.08" - id="tspan3643">CoA</tspan></text> - <path + id="tspan3643">CoA</tspan></text><path id="F_ACONTm" fill-rule="evenodd" clip-rule="evenodd" d="m 1243.73,1336.25 10.55,-0.9 -9.32,-4.94 1.87,3.42 z" stroke="#000000" - stroke-width="2.77105" /> - <path + stroke-width="2.77105" /><path id="R_ACONTm" d="m 1185.58,1345.25 c 17.14,-8.47 40.14,-14.47 62.64,-11.47" stroke="#000000" - stroke-width="2.77105" /> - <path + stroke-width="2.77105" /><path id="R_SUCD1m" d="m 1240,1651.5 c -25,0 -55,-9.5 -69,-17.5 m 10.87,23.01 c -0.49,-2.88 -1.37,-14.01 19.13,-11.23 21.5,4.39 20.36,15.65 19.52,18.28" stroke="#000000" - stroke-width="2.40733" /> - <g - id="text6997-5-9-4-3-3"> - <text + stroke-width="2.40733" /><g + id="text6997-5-9-4-3-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9313,8 +8034,7 @@ id="tspan3649">H</tspan><tspan x="1090.28" y="1614.3" - id="tspan3651">O</tspan></text> - <text + id="tspan3651">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9324,39 +8044,31 @@ id="text3657"><tspan x="1086.05" y="1614.3" - id="tspan3655">₂</tspan></text> - </g> - <path + id="tspan3655">₂</tspan></text></g><path id="F_FUMm" d="m 1104.8,1561.16 c -7.2,-7.16 -7.2,-7.16 -7.2,-7.16 l 2.15,9.92 1.36,-3.52 z" stroke="#000000" - stroke-width="2.36402" /> - <path + stroke-width="2.36402" /><path id="R_MDHm" d="m 1093.96,1522.36 c -1.96,-7.1 -3.86,-16.09 -4.99,-24.86 m 4.99,-49 c -2.95,9.55 -5.41,20.81 -5.96,30.5 m 0,0 c 2.6,-12.5 11.5,-13.5 11.5,-13.5 M 1088,1479 c -0.16,2.92 -0.12,6.13 0.09,9.5 m 0.88,9 c 1.78,11 11.53,8.5 11.53,8.5 m -11.53,-8.5 c -0.4,-3.06 -0.7,-6.09 -0.88,-9 m 0,0 c 5.87,-11 12.41,-9.5 12.41,-9.5" stroke="#000000" - stroke-width="2.03667" /> - <path + stroke-width="2.03667" /><path id="F_SUCD1m" d="m 1179.39,1655.18 c 1.95,8.73 1.95,8.73 1.95,8.73 l 3.75,-8.55 -3.08,2.07 z M 1173,1633 l -6,-2 2.5,4.5 1,-1.5 z" stroke="#000000" - stroke-width="2.36402" /> - <path + stroke-width="2.36402" /><path id="B_SUCD1m" d="m 1217.18,1662.86 c 2.97,9.7 2.97,9.7 2.97,9.7 l 2.79,-9.76 -2.86,2.46 z m 20.82,-9.36 6,-2 -4.5,-1.5 v 1 z" stroke="#000000" - stroke-width="2.36402" /> - <path + stroke-width="2.36402" /><path id="F_ICDHym" d="m 1436.78,1417.55 c 6.92,7.42 6.92,7.42 6.92,7.42 l -1.78,-9.99 -1.48,3.46 z m 14.5,-17.37 c 7.24,-6.22 7.24,-6.22 7.24,-6.22 l -9.19,2.43 3.03,0.81 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="F_MDHm" d="m 1099.5,1466.5 3,-2.5 h -4.5 l 1.5,1.5 z m -2.54,-16.35 c -1.84,-8.75 -1.84,-8.75 -1.84,-8.75 l -3.85,8.5 3.1,-2.03 z" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text3668" fill="#000000" xml:space="preserve" @@ -9366,10 +8078,8 @@ letter-spacing="0em"><tspan x="1108.49" y="1482.16" - id="tspan3666">NADH</tspan></text> - <g - id="text2536_2"> - <text + id="tspan3666">NADH</tspan></text><g + id="text2536_2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9379,8 +8089,7 @@ id="text3672"><tspan x="1107.0601" y="1464.16" - id="tspan3670">H</tspan></text> - <text + id="tspan3670">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -9390,13 +8099,10 @@ id="text3676"><tspan x="1115.73" y="1464.16" - 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id="tspan4389">Leu, 4mop</tspan></text> - <text + id="tspan4389">Leu, 4mop</tspan></text><text id="text14626-4-3" transform="translate(1620.02,2006.1)" fill="#000000" @@ -11982,13 +10286,11 @@ letter-spacing="0em"><tspan x="0.125" y="14.5469" - id="tspan4392">Lys, 2oxoadp</tspan></text> - <path + id="tspan4392">Lys, 2oxoadp</tspan></text><path id="F_HMGCOASm" d="m 1458.03,1929 -2.49,9.84 2.77,-2.55 2.97,2.33 z m -13.03,13 -4,2 4.5,1.5 -0.5,-2 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="AcCoA" fill="#000000" xml:space="preserve" @@ -11998,10 +10300,8 @@ letter-spacing="0em"><tspan x="1405.3199" y="2000.16" - id="tspan4396">AcCoA</tspan></text> - <g - id="H2O_3"> - <text + id="tspan4396">AcCoA</tspan></text><g + id="H2O_3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12014,8 +10314,7 @@ id="tspan4399">H</tspan><tspan x="1432.28" y="2024.16" - id="tspan4401">O</tspan></text> - <text + id="tspan4401">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12025,9 +10324,7 @@ id="text4407"><tspan x="1428.05" y="2024.16" - 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inkscape:label="3SALATAm f" /> - <path + inkscape:label="3SALATAm f" /><path d="m 804.85852,1122.4828 c -2.79275,-10.8348 5.29287,-17.2115 5.29287,-17.2115 m -20.1208,-0.021 65.83006,-0.6776 m -28.71369,0.9186 c 6.54309,1.8415 5.15148,17.1709 5.15148,17.1709" id="R_3SALATAim" style="fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:1.48763;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:4;stroke-dasharray:none;stroke-opacity:1" inkscape:connector-curvature="0" - inkscape:label="3SALATAm" /> - <text + inkscape:label="3SALATAm" /><text id="text5381" style="font-style:normal;font-weight:normal;font-size:8.02297px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1.06973px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="matrix(1.0010463,-0.00184929,0.00185317,0.99895137,0,0)" @@ -12283,8 +10548,7 @@ style="font-size:8.02297px;stroke-width:1.06973px" x="821.88116" y="1138.7268" - sodipodi:role="line">Glu</tspan></text> - <text + sodipodi:role="line">Glu</tspan></text><text id="text5385" style="font-style:normal;font-weight:normal;font-size:8.02297px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1.06973px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="matrix(1.0010408,0.00378594,-0.00379389,0.99894594,0,0)" @@ -12295,8 +10559,7 @@ style="font-size:8.02297px;stroke-width:1.06973px" x="791.85028" y="1131.0659" - sodipodi:role="line">H+AKG</tspan></text> - <text + sodipodi:role="line">H+AKG</tspan></text><text id="text5323-2-5-9-8-5-3" transform="rotate(0.11511016)" fill="#000000" @@ -12310,19 +10573,16 @@ y="1097.8229"><tspan x="488.01974" y="1112.3698" - id="tspan4189-3-6-0-5">3sPyr</tspan></text> - <path + id="tspan4189-3-6-0-5">3sPyr</tspan></text><path d="m 574.27531,1108.0122 c -6.54311,1.8415 -5.15143,17.1709 -5.15143,17.1709 m 102.19841,-18.5671 -124.55561,0.4953 m 49.71265,23.6811 c 2.71169,-14.4316 -5.13927,-22.9252 -5.13927,-22.9252" id="R_3SALATAi" style="fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:1.48763;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:4;stroke-dasharray:none;stroke-opacity:1" - 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id="tspan4521">7 FAD</tspan></text> - <g - id="text7967-0-3-65-5-3-5-1-2-8-1-2-56"> - <text + id="tspan4521">7 FAD</tspan></text><g + id="text7967-0-3-65-5-3-5-1-2-8-1-2-56"><text transform="rotate(0.250513,-404529.67,344198.59)" fill="#000000" xml:space="preserve" @@ -12909,8 +11087,7 @@ id="text4526"><tspan x="0.21406201" y="11.1602" - id="tspan4524">7 NAD</tspan></text> - <text + id="tspan4524">7 NAD</tspan></text><text transform="rotate(0.250513,-404529.67,344198.59)" fill="#000000" xml:space="preserve" @@ -12921,9 +11098,7 @@ id="text4530"><tspan x="35.5812" y="11.1602" - id="tspan4528">⁺</tspan></text> - </g> - <text + id="tspan4528">⁺</tspan></text></g><text id="text7967-0-3-65-5-3-5-1-2-8-1-2-8" transform="rotate(0.250513,-404553.17,333449.05)" fill="#000000" @@ -12934,10 +11109,8 @@ letter-spacing="0em"><tspan x="0.3125" y="11.1602" - id="tspan4533">7 CoA</tspan></text> - <g - id="text7967-0-3-65-5-3-5-1-2-8-1-2-6"> - <text + id="tspan4533">7 CoA</tspan></text><g + id="text7967-0-3-65-5-3-5-1-2-8-1-2-6"><text transform="rotate(0.250513,-404577.17,322470.81)" fill="#000000" xml:space="preserve" @@ -12951,8 +11124,7 @@ id="tspan4536">7 H</tspan><tspan x="23.287701" y="11.1602" - 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fill="#25ca25" /> - </g> - <g + fill="#25ca25" /></g><g id="g36" inkscape:label="aa_synthesis" - transform="matrix(1.0039221,0,0,1.0018211,-10.330425,-14.030774)"> - <g + transform="matrix(1.0039221,0,0,1.0018211,-10.330425,-14.030774)"><g id="Group 91" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text id="text1172" fill="#000000" xml:space="preserve" @@ -13179,13 +11321,11 @@ letter-spacing="0em"><tspan x="740.09399" y="545.547" - id="tspan5022">CySS</tspan></text> - <path + id="tspan5022">CySS</tspan></text><path id="R_CYSGLTH" d="m 804.5,528.5 c 0,11.852 21.595,12.314 21.595,12.314 25.405,0 25.405,-12.314 25.405,-12.314 m -67,12.314 h 83.191" stroke="#000000" - stroke-width="1.489" /> - <text + stroke-width="1.489" /><text id="text1178" fill="#000000" xml:space="preserve" @@ -13195,8 +11335,7 @@ letter-spacing="0em"><tspan x="782.48199" y="524.15997" - id="tspan5026">2 GSH</tspan></text> - 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stroke-width="2.66667" /> - <g - id="text1260"> - <text + stroke-width="2.66667" /><g + id="text1260"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13354,8 +11473,7 @@ id="tspan5070">H</tspan><tspan x="725.27802" y="575.15997" - id="tspan5072">O</tspan></text> - <text + id="tspan5072">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13365,11 +11483,8 @@ id="text5078"><tspan x="721.05402" y="575.15997" - id="tspan5076">₂</tspan></text> - </g> - <g - id="text1264"> - <text + id="tspan5076">₂</tspan></text></g><g + id="text1264"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13379,8 +11494,7 @@ id="text5083"><tspan x="684.32397" y="575.15997" - id="tspan5081">NH</tspan></text> - <text + id="tspan5081">NH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13390,19 +11504,15 @@ id="text5088"><tspan x="701.66803" y="575.15997" - id="tspan5085">₃</tspan></text> - </g> - <path + id="tspan5085">₃</tspan></text></g><path id="F_CystinePyruvate" d="m 692.073,556.576 c 2.216,6.889 2.216,6.889 2.216,6.889 l 2.325,-6.86 -2.284,1.704 z M 676.762,538 C 667,540.779 667,540.779 667,540.779 l 9.705,2.973 -2.405,-2.9 z" stroke="#000000" - 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transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text id="text7967-0-3-6-2-7-4-34-22" fill="#000000" xml:space="preserve" @@ -13444,8 +11548,7 @@ letter-spacing="0em"><tspan x="591.375" y="515.547" - id="tspan5100">Asn</tspan></text> - <text + id="tspan5100">Asn</tspan></text><text id="AMP" transform="rotate(0.638475,-49528.266,49826.63)" fill="#000000" @@ -13456,8 +11559,7 @@ letter-spacing="0em"><tspan x="0.49804699" y="11.1602" - id="tspan5103">AMP</tspan></text> - <text + id="tspan5103">AMP</tspan></text><text id="Glu" transform="rotate(0.638475,-47370.565,50532.531)" fill="#000000" @@ -13468,8 +11570,7 @@ letter-spacing="0em"><tspan x="0.15429699" y="11.1602" - id="tspan5106">Glu</tspan></text> - <text + id="tspan5106">Glu</tspan></text><text id="PPi" transform="rotate(0.638475,-51947.18,50558.031)" fill="#000000" @@ -13480,8 +11581,7 @@ letter-spacing="0em"><tspan x="0.160156" y="11.1602" - id="tspan5109">PPi</tspan></text> - <text + id="tspan5109">PPi</tspan></text><text id="ATP" transform="rotate(0.638475,-57150.458,50856.244)" fill="#000000" @@ -13492,8 +11592,7 @@ letter-spacing="0em"><tspan x="0.27343801" y="11.1602" - id="tspan5112">ATP</tspan></text> - <text + id="tspan5112">ATP</tspan></text><text id="Gln" transform="rotate(0.638475,-59032.947,51225.694)" fill="#000000" @@ -13504,10 +11603,8 @@ letter-spacing="0em"><tspan x="0.15429699" y="11.1602" - id="tspan5115">Gln</tspan></text> - <g - id="H2O_4"> - <text + id="tspan5115">Gln</tspan></text><g + id="H2O_4"><text transform="rotate(0.638475,-54817.282,50843.244)" fill="#000000" xml:space="preserve" @@ -13521,8 +11618,7 @@ id="tspan5118">H</tspan><tspan x="13.2779" y="11.1602" - id="tspan5120">O</tspan></text> - <text + id="tspan5120">O</tspan></text><text transform="rotate(0.638475,-54817.282,50843.244)" fill="#000000" xml:space="preserve" @@ -13533,16 +11629,12 @@ id="text5126"><tspan x="9.0541096" y="11.1602" - id="tspan5124">₂</tspan></text> - </g> - <path + id="tspan5124">₂</tspan></text></g><path id="R_ASNS1" d="M 603.542,529.162 V 677 m 10e-4,-43.5 c -10e-4,13 -14.736,13 -14.736,13 m 0,-81.5 c 15.76,0 14.735,16.5 14.735,16.5 m -14.735,39 c 0,0 14.735,0 14.735,-13 0,0 1.025,-16.5 -14.734,-16.5 m 14.734,65.5 c 0,13 -14.735,13 -14.735,13 m 0,-130.5 c 15.76,0 14.735,16.5 14.735,16.5" stroke="#000000" - stroke-width="2.99247" /> - <g - id="text7967-0-3-65-1-3-2-82-8-2"> - <text + stroke-width="2.99247" /><g + id="text7967-0-3-65-1-3-2-82-8-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13555,8 +11647,7 @@ id="tspan5130">H</tspan><tspan x="643.27802" y="607.15997" - id="tspan5132">O</tspan></text> - <text + id="tspan5132">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13566,11 +11657,8 @@ id="text5138"><tspan x="639.05402" y="607.15997" - id="tspan5136">₂</tspan></text> - </g> - <g - id="text7967-0-3-65-1-3-2-82-8-3"> - <text + id="tspan5136">₂</tspan></text></g><g + id="text7967-0-3-65-1-3-2-82-8-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13580,8 +11668,7 @@ id="text5143"><tspan x="637.32397" y="639.15997" - id="tspan5141">NH</tspan></text> - <text + id="tspan5141">NH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13591,24 +11678,19 @@ id="text5147"><tspan x="654.66803" y="639.15997" - id="tspan5145">₃</tspan></text> - </g> - <path + id="tspan5145">₃</tspan></text></g><path id="F_ASNS1" d="M 600.73,529.586 C 603.236,521 603.236,521 603.236,521 l 2.732,8.503 -2.647,-2.095 z m -9.363,7.54 C 582,538.924 582,538.924 582,538.924 l 9.174,2.456 -2.221,-2.209 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_ASNN" d="m 612.765,521 -0.019,146.604 M 626.645,602 c 0,0 -13.89,0 -13.893,17.5 0,0 -0.002,16 13.893,16" stroke="#000000" - stroke-width="2.99066" /> - <path + stroke-width="2.99066" /><path id="F_ASNN" d="m 615.377,666.402 c -2.943,8.447 -2.943,8.447 -2.943,8.447 l -2.292,-8.632 2.536,2.227 z m 9.799,-28.893 C 634.5,635.5 634.5,635.5 634.5,635.5 l -9.228,-2.248 2.271,2.159 z" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-3-0-8-9-3" fill="#000000" xml:space="preserve" @@ -13619,12 +11701,9 @@ letter-spacing="0em"><tspan x="591.375" y="690.547" - id="tspan5153">Asp</tspan></text> - </g> - <g + id="tspan5153">Asp</tspan></text></g><g id="Group 116" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text id="text7967-0-3-6-2-7-4-34-4-6-2-4" fill="#000000" xml:space="preserve" @@ -13635,8 +11714,7 @@ letter-spacing="0em"><tspan x="1257.4301" y="599.547" - id="tspan5157">P5C</tspan></text> - <text + id="tspan5157">P5C</tspan></text><text id="text7967-0-3-6-2-7-4-34-4-6-2-4-5" fill="#000000" xml:space="preserve" @@ -13647,30 +11725,24 @@ letter-spacing="0em"><tspan x="1262.16" y="686.547" - id="tspan5160">Pro</tspan></text> - <path + id="tspan5160">Pro</tspan></text><path id="R_PRO1x" d="m 1253.35,651.139 c 9.4,2.665 14.25,-6.543 14.25,-6.543 M 1255.5,610.5 c 0,0 11.42,-3.5 11.48,9 0.06,12.5 -11.48,12.5 -11.48,12.5 m 11.4,-29.036 0.3,61.548" stroke="#000000" - stroke-width="1.90151" /> - <path + stroke-width="1.90151" /><path id="F_PRO1x" d="m 1255.13,649.081 c -9.46,1.221 -9.46,1.221 -9.46,1.221 l 9.01,3.013 -2.08,-2.341 z m 9.13,14.162 c 3.02,8.418 3.02,8.418 3.02,8.418 l 2.21,-8.654 -2.51,2.252 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_P5CR" d="m 1291.5,651 c -9.89,0 -9.89,-10.5 -9.89,-34 m 0,0 c 0,-8 9.89,-7.5 9.89,-7.5 m -9.89,7.5 c 0,13.5 9.89,13.5 9.89,13.5 m -9.89,-27.5 v 61.512" stroke="#000000" - stroke-width="1.90151" /> - <path + stroke-width="1.90151" /><path id="F_P5CR" d="m 1289.54,648.548 c 9.46,1.221 9.46,1.221 9.46,1.221 l -9.01,3.012 2.09,-2.341 z m -4.99,14.695 c -3.03,8.418 -3.03,8.418 -3.03,8.418 l -2.21,-8.654 2.52,2.252 z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="text3908"> - <text + stroke-width="2.23952" /><g + id="text3908"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13680,8 +11752,7 @@ id="text5169"><tspan x="1241.0601" y="635.15997" - id="tspan5167">H</tspan></text> - <text + id="tspan5167">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13691,9 +11762,7 @@ id="text5173"><tspan x="1249.73" y="635.15997" - id="tspan5171">⁺</tspan></text> - </g> - <text + id="tspan5171">⁺</tspan></text></g><text id="text3908_2" fill="#000000" xml:space="preserve" @@ -13703,10 +11772,8 @@ letter-spacing="0em"><tspan x="1220.49" y="614.15997" - id="tspan5176">NADH</tspan></text> - <g - id="text3920"> - <text + id="tspan5176">NADH</tspan></text><g + id="text3920"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13716,8 +11783,7 @@ id="text5181"><tspan x="1293.0601" y="635.15997" - id="tspan5179">H</tspan></text> - <text + id="tspan5179">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13727,9 +11793,7 @@ id="text5185"><tspan x="1301.73" y="635.15997" - id="tspan5183">⁺</tspan></text> - </g> - <text + id="tspan5183">⁺</tspan></text></g><text id="text3920_2" fill="#000000" xml:space="preserve" @@ -13739,10 +11803,8 @@ letter-spacing="0em"><tspan x="1292.49" y="614.15997" - id="tspan5188">NADPH</tspan></text> - <g - id="text3932"> - <text + id="tspan5188">NADPH</tspan></text><g + id="text3932"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13752,8 +11814,7 @@ id="text5193"><tspan x="1215.22" y="653.15997" - id="tspan5191">NAD</tspan></text> - <text + id="tspan5191">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13763,11 +11824,8 @@ id="text5197"><tspan x="1240.5699" y="653.15997" - id="tspan5195">⁺</tspan></text> - </g> - <g - id="text3938"> - <text + id="tspan5195">⁺</tspan></text></g><g + id="text3938"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13777,8 +11835,7 @@ id="text5202"><tspan x="1301.22" y="653.15997" - id="tspan5200">NADP</tspan></text> - <text + id="tspan5200">NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13788,11 +11845,8 @@ id="text5206"><tspan x="1334.5699" y="653.15997" - id="tspan5204">⁺</tspan></text> - </g> - <g - id="Group 100"> - <text + id="tspan5204">⁺</tspan></text></g><g + id="Group 100"><text id="text7967-0-3-6-2-7-4-34-4-6-2" fill="#000000" xml:space="preserve" @@ -13803,10 +11857,8 @@ letter-spacing="0em"><tspan x="1168.04" y="598.547" - id="tspan5209">GluSA</tspan></text> - <g - id="text7967-0-3-65-1-2-4-9-8-0-9-2"> - <text + id="tspan5209">GluSA</tspan></text><g + id="text7967-0-3-65-1-2-4-9-8-0-9-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13819,8 +11871,7 @@ id="tspan5212">H</tspan><tspan x="1231.28" y="569.15997" - id="tspan5214">O</tspan></text> - <text + id="tspan5214">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13830,37 +11881,27 @@ id="text5220"><tspan x="1227.05" y="569.15997" - id="tspan5218">₂</tspan></text> - </g> - <path + id="tspan5218">₂</tspan></text></g><path id="R_G5SADs" d="m 1247.5,593.5 h -29 c 0,0 11.5,0 11.5,-11" stroke="#000000" - stroke-width="2.32025" /> - <path + stroke-width="2.32025" /><path id="F_G5SADs" d="m 1246.53,591.078 c 8.42,3.024 8.42,3.024 8.42,3.024 l -8.65,2.209 2.25,-2.514 z m -18.42,-6.592 c 1.22,-9.46 1.22,-9.46 1.22,-9.46 l 3.01,9.007 -2.34,-2.082 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - </g> - <g + stroke-width="2.23952" /></g></g><g id="Group 99" transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)" - inkscape:label="Group 99"> - <path + inkscape:label="Group 99"><path id="R_GLUN" d="m 1382,616 c 16.09,0 16.09,17 16.09,17 0,18.5 -16.09,18.5 -16.09,18.5 m 16.09,-60.5 v 103.661" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="F_GLUN" d="m 1400.85,692.537 c -3.44,9.547 -3.44,9.547 -3.44,9.547 l -2.3,-9.887 2.73,2.6 z m -16.49,-38.932 c -9.32,-2.036 -9.32,-2.036 -9.32,-2.036 l 9.24,-2.22 -2.28,2.151 z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="text3504-6"> - <text + stroke-width="2.23952" /><g + id="text3504-6"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13870,8 +11911,7 @@ id="text5231"><tspan x="1355.3199" y="657.15997" - id="tspan5229">NH</tspan></text> - <text + id="tspan5229">NH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13881,9 +11921,7 @@ id="text5235"><tspan x="1372.67" y="657.15997" - id="tspan5233">₃</tspan></text> - </g> - <text + id="tspan5233">₃</tspan></text></g><text id="text3514-0" fill="#000000" xml:space="preserve" @@ -13894,10 +11932,8 @@ letter-spacing="0em"><tspan x="1390.16" y="587.547" - id="tspan5238">Gln</tspan></text> - <g - id="text3565-0"> - <text + id="tspan5238">Gln</tspan></text><g + id="text3565-0"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13910,8 +11946,7 @@ id="tspan5241">H</tspan><tspan x="1369.28" y="620.15997" - id="tspan5243">O</tspan></text> - <text + id="tspan5243">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13921,11 +11956,8 @@ id="text5249"><tspan x="1365.05" y="620.15997" - id="tspan5247">₂</tspan></text> - </g> - <g - id="text3687-9"> - <text + id="tspan5247">₂</tspan></text></g><g + id="text3687-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13935,8 +11967,7 @@ id="text5254"><tspan x="1433.13" y="667.422" - id="tspan5252">NH</tspan></text> - <text + id="tspan5252">NH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13946,9 +11977,7 @@ id="text5259"><tspan x="1450.47" y="667.422" - id="tspan5256">₃</tspan></text> - </g> - <text + id="tspan5256">₃</tspan></text></g><text id="text3691-0" fill="#000000" xml:space="preserve" @@ -13958,18 +11987,15 @@ letter-spacing="0em"><tspan x="1432.08" y="649.422" - id="tspan5262">ATP</tspan></text> - <path + id="tspan5262">ATP</tspan></text><path id="F_GLNS" d="m 1424.66,611.109 c 9.32,-2.036 9.32,-2.036 9.32,-2.036 l -9.23,-2.221 2.27,2.152 z m 0,16 c 9.32,-2.036 9.32,-2.036 9.32,-2.036 l -9.23,-2.221 2.27,2.152 z m -13.51,-25.047 c -3.32,-9.591 -3.32,-9.591 -3.32,-9.591 l -2.43,9.856 2.76,-2.564 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_GLNS" d="m 1429.87,609.926 c -12.99,-3.437 -21.18,4.973 -21.18,4.973 m 0.41,42.437 c 1.99,7.051 21.59,6.235 21.59,6.235 m -0.82,-37.645 c -12.99,-3.437 -21.18,4.973 -21.18,4.973 m 0.41,8.437 c 1.99,7.051 21.59,6.235 21.59,6.235 M 1408.78,601.213 1408.69,704" stroke="#000000" - 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id="tspan781">Glu</tspan></text> - <path + id="tspan781">Glu</tspan></text><path id="F_ALATA_L" fill-rule="evenodd" clip-rule="evenodd" d="m 655,831.5 -4.5,-5 -3,5 3.296,-2.868 z m 68.492,-58.067 -3.492,-7.234 -2.261,7.234 2.877,-2.433 1.438,1.217 z" stroke="#000000" - stroke-width="2.32759" /> - <path + stroke-width="2.32759" /><path id="R_ALATA_L" d="m 624.5,837.591 c 0,0 3,15.012 18,9.72 15,-5.291 8,-18.22 8,-18.22 M 292.5,967 l 233,-81 c 0,0 0,-10.481 13,-15.5 15,-5.791 21,3.5 21,3.5 l 160.161,-51.5 v -54" stroke="#000000" - stroke-width="2.22" /> - <path + stroke-width="2.22" /><path id="B_ALATA_L" d="m 626,838 -2.5,-3.5 v 5 l 1.296,-1.868 z m -332.5,126.501 -7.5,5.5 9,-1 -3,-1 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - </g> - </g> - <g + stroke-width="2.23952" /></g></g></g><g id="path_nucleotide_synthesis" - transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"><g id="g40" - inkscape:label="box_nucleotide_synthesis"> - 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id="Group 24"> - <text + fill="#29bc90" /></g><g + id="Group 24"><text id="text5630" transform="rotate(0.808348,-28675.529,115046.02)" fill="#2b0000" @@ -15903,8 +13622,7 @@ x="0.160156" y="11.1602" id="tspan1722" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text5634" transform="rotate(-0.829907,29539.626,-109837.75)" fill="#2b0000" @@ -15916,8 +13634,7 @@ x="0.27343801" y="11.1602" id="tspan1725" - style="fill:#000000">ATP</tspan></text> - <text + style="fill:#000000">ATP</tspan></text><text id="text5640" fill="#000000" xml:space="preserve" @@ -15928,8 +13645,7 @@ letter-spacing="0em"><tspan x="1641.49" y="406.547" - id="tspan1728">dTTP</tspan></text> - <path + id="tspan1728">dTTP</tspan></text><path id="B_NDPK4" fill-rule="evenodd" clip-rule="evenodd" @@ -15937,8 +13653,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_NDPK4" fill-rule="evenodd" clip-rule="evenodd" @@ -15946,19 +13661,16 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - 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stroke-width="2.20342" /> - <text + stroke-width="2.20342" /><text id="text7967-4" fill="#000000" xml:space="preserve" @@ -15969,8 +13681,7 @@ letter-spacing="0em"><tspan x="922" y="288.31201" - id="tspan1739">PRPP</tspan></text> - <text + id="tspan1739">PRPP</tspan></text><text id="text6997-5-1-8-3-7-4-9" fill="#000000" xml:space="preserve" @@ -15980,8 +13691,7 @@ letter-spacing="0em"><tspan x="988.49402" y="305.16" - id="tspan1742">Gly</tspan></text> - <text + id="tspan1742">Gly</tspan></text><text id="text6997-5-1-8-3-71-2-7-5" fill="#000000" xml:space="preserve" @@ -15991,8 +13701,7 @@ letter-spacing="0em"><tspan x="1041.47" y="305.16" - id="tspan1745">2 10fTHF</tspan></text> - <text + id="tspan1745">2 10fTHF</tspan></text><text id="text6997-5-1-8-3-7-7-9-1" fill="#000000" xml:space="preserve" @@ -16002,8 +13711,7 @@ letter-spacing="0em"><tspan x="959.42999" y="260.16" - id="tspan1748">2 THF</tspan></text> - <text + id="tspan1748">2 THF</tspan></text><text id="text6997-5-1-8-3-71-5-6-19" fill="#000000" xml:space="preserve" @@ -16013,8 +13721,7 @@ letter-spacing="0em"><tspan x="1066.16" y="261.16" - id="tspan1751">PPi</tspan></text> - <text + id="tspan1751">PPi</tspan></text><text id="text6997-5-1-8-3-71-5-7-36-5" fill="#000000" xml:space="preserve" @@ -16024,8 +13731,7 @@ letter-spacing="0em"><tspan x="1125.48" y="261.16" - id="tspan1754">4 ADP</tspan></text> - <text + id="tspan1754">4 ADP</tspan></text><text id="text6997-5-1-8-3-71-5-7-3-5-0" fill="#000000" xml:space="preserve" @@ -16035,8 +13741,7 @@ letter-spacing="0em"><tspan x="1033.49" y="260.16" - id="tspan1757">Fum</tspan></text> - <text + id="tspan1757">Fum</tspan></text><text id="text7967-5-8" fill="#000000" xml:space="preserve" @@ -16046,8 +13751,7 @@ letter-spacing="0em"><tspan x="957.14502" y="305.16" - id="tspan1760">2 Gln</tspan></text> - <text + id="tspan1760">2 Gln</tspan></text><text id="text6997-5-1-8-3-71-5-6-1-3" fill="#000000" xml:space="preserve" @@ -16057,8 +13761,7 @@ letter-spacing="0em"><tspan x="999.14502" y="260.16" - id="tspan1763">2 Glu</tspan></text> - <text + id="tspan1763">2 Glu</tspan></text><text id="text6997-5-1-8-3-7-4-9-6" fill="#000000" xml:space="preserve" @@ -16068,8 +13771,7 @@ letter-spacing="0em"><tspan x="1132.1" y="305.16" - id="tspan1766">4 ATP</tspan></text> - <text + id="tspan1766">4 ATP</tspan></text><text id="text6997-5-1-8-3-7-4-9-2" fill="#000000" xml:space="preserve" @@ -16079,10 +13781,8 @@ letter-spacing="0em"><tspan x="1010.16" y="304.16" - id="tspan1769">Asp</tspan></text> - <g - id="text6997-5-1-8-3-7-4-9-7"> - <text + id="tspan1769">Asp</tspan></text><g + id="text6997-5-1-8-3-7-4-9-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16095,8 +13795,7 @@ id="tspan1772">H</tspan><tspan x="1114.28" y="305.16" - id="tspan1774">O</tspan></text> - <text + id="tspan1774">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16106,11 +13805,8 @@ id="text1780"><tspan x="1110.05" y="305.16" - id="tspan1778">₂</tspan></text> - </g> - <g - id="text7967-5-8-5"> - <text + id="tspan1778">₂</tspan></text></g><g + id="text7967-5-8-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16120,8 +13816,7 @@ id="text1785"><tspan x="1169.49" y="305.16" - id="tspan1783">CO</tspan></text> - <text + id="tspan1783">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16131,9 +13826,7 @@ id="text1789"><tspan x="1187.5" y="305.16" - id="tspan1787">₂</tspan></text> - </g> - <text + id="tspan1787">₂</tspan></text></g><text id="text6997-5-1-8-3-7-4-9-4" fill="#000000" xml:space="preserve" @@ -16143,8 +13836,7 @@ letter-spacing="0em"><tspan x="1012.16" y="377.16" - id="tspan1792">Asp</tspan></text> - <text + id="tspan1792">Asp</tspan></text><text id="text6997-5-1-8-3-71-2-7-5-2" fill="#000000" xml:space="preserve" @@ -16154,10 +13846,8 @@ letter-spacing="0em"><tspan x="928.09802" y="377.16" - id="tspan1795">2 ATP</tspan></text> - <g - id="text6997-5-1-8-3-7-7-9-1-8"> - <text + id="tspan1795">2 ATP</tspan></text><g + id="text6997-5-1-8-3-7-7-9-1-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16167,8 +13857,7 @@ id="text1800"><tspan x="965.48999" y="328.16" - id="tspan1798">QH</tspan></text> - <text + id="tspan1798">QH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16178,9 +13867,7 @@ id="text1804"><tspan x="983.50201" y="328.16" - id="tspan1802">₂</tspan></text> - </g> - <text + id="tspan1802">₂</tspan></text></g><text id="text6997-5-1-8-3-71-5-7-36-5-3" fill="#000000" xml:space="preserve" @@ -16190,8 +13877,7 @@ letter-spacing="0em"><tspan x="1017.48" y="330.16" - id="tspan1807">2 ADP</tspan></text> - <text + id="tspan1807">2 ADP</tspan></text><text id="text7967-5-8-3" fill="#000000" xml:space="preserve" @@ -16201,8 +13887,7 @@ letter-spacing="0em"><tspan x="968.15399" y="377.16" - id="tspan1810">Gln</tspan></text> - <text + id="tspan1810">Gln</tspan></text><text id="text6997-5-1-8-3-71-5-6-1-3-1" fill="#000000" xml:space="preserve" @@ -16212,10 +13897,8 @@ letter-spacing="0em"><tspan x="993.15399" y="330.16" - id="tspan1813">Glu</tspan></text> - <g - id="text6997-5-1-8-3-7-4-9-6-3"> - <text + id="tspan1813">Glu</tspan></text><g + id="text6997-5-1-8-3-7-4-9-6-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16225,8 +13908,7 @@ id="text1818"><tspan x="1064.35" y="377.16" - id="tspan1816">HCO</tspan></text> - <text + id="tspan1816">HCO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16236,8 +13918,7 @@ id="text1822"><tspan x="1091.03" y="377.16" - id="tspan1820">₃</tspan></text> - <text + id="tspan1820">₃</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16247,9 +13928,7 @@ id="text1826"><tspan x="1095.25" y="377.16" - id="tspan1824">⁻</tspan></text> - </g> - <text + id="tspan1824">⁻</tspan></text></g><text id="text6997-5-1-8-3-7-4-9-2-2" fill="#000000" xml:space="preserve" @@ -16259,10 +13938,8 @@ letter-spacing="0em"><tspan x="995.33002" y="377.16" - id="tspan1829">Q</tspan></text> - <g - id="text6997-5-1-8-3-7-4-9-7-7"> - <text + id="tspan1829">Q</tspan></text><g + id="text6997-5-1-8-3-7-4-9-7-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16272,8 +13949,7 @@ id="text1834"><tspan x="1048.0601" y="377.16" - id="tspan1832">H</tspan></text> - <text + id="tspan1832">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16283,9 +13959,7 @@ id="text1838"><tspan x="1056.73" y="377.16" - id="tspan1836">⁺</tspan></text> - </g> - <text + id="tspan1836">⁺</tspan></text></g><text id="text6997-5-1-8-3-71-5-7-36-5-8-7" fill="#000000" xml:space="preserve" @@ -16295,10 +13969,8 @@ letter-spacing="0em"><tspan x="1083.84" y="331.27802" - id="tspan1841">PPi</tspan></text> - <g - id="text6997-5-1-8-3-71-5-7-36-5-8-9"> - <text + id="tspan1841">PPi</tspan></text><g + id="text6997-5-1-8-3-71-5-7-36-5-8-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16308,8 +13980,7 @@ id="text1846"><tspan x="1107.49" y="331.16" - id="tspan1844">CO</tspan></text> - <text + id="tspan1844">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16319,9 +13990,7 @@ id="text1850"><tspan x="1125.5" y="331.16" - id="tspan1848">₂</tspan></text> - </g> - <text + id="tspan1848">₂</tspan></text></g><text id="text7967-0-3-6-2-78" fill="#000000" xml:space="preserve" @@ -16332,8 +14001,7 @@ letter-spacing="0em"><tspan x="1221.1" y="358.547" - id="tspan1853">UDP</tspan></text> - <text + id="tspan1853">UDP</tspan></text><text id="text7967-0-3-65-5-4" fill="#000000" xml:space="preserve" @@ -16343,8 +14011,7 @@ letter-spacing="0em"><tspan x="1171.27" y="336.16" - id="tspan1856">ATP</tspan></text> - <text + id="tspan1856">ATP</tspan></text><text id="text7967-0-3-65-1-8" fill="#000000" xml:space="preserve" @@ -16354,8 +14021,7 @@ letter-spacing="0em"><tspan x="1196.16" y="336.16" - id="tspan1859">ADP</tspan></text> - <text + id="tspan1859">ADP</tspan></text><text id="text7967-0-3-6-2-7-6" fill="#000000" xml:space="preserve" @@ -16366,10 +14032,8 @@ letter-spacing="0em"><tspan x="1212.21" y="406.547" - id="tspan1862">dUDP</tspan></text> - <g - id="text7967-0-3-65-1-3-5"> - <text + id="tspan1862">dUDP</tspan></text><g + id="text7967-0-3-65-1-3-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16382,8 +14046,7 @@ id="tspan1865">H</tspan><tspan x="1268.28" y="378.16" - id="tspan1867">O</tspan></text> - <text + id="tspan1867">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16393,19 +14056,15 @@ id="text1873"><tspan x="1264.05" y="378.16" - id="tspan1871">₂</tspan></text> - </g> - <path + id="tspan1871">₂</tspan></text></g><path id="B_UMPK" d="m 1189.5,344.52 -1.5,-3.5 -1.5,3.5 1.68,-0.617 z m -8,7 -6.5,2.355 6.51,2.296 -1.82,-2.296 z" stroke="#000000" - stroke-width="2.66667" /> - <path + stroke-width="2.66667" /><path id="F_UMPK" d="M 1202.51,344.933 C 1200.82,340 1200.82,340 1200.82,340 l -2.49,4.771 2.19,-1.132 z m 7.08,11.614 c 7.49,-2.521 7.49,-2.521 7.49,-2.521 l -7.66,-1.958 1.98,2.169 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text7967-0-3-6-2-2-7" transform="rotate(-0.392185,57966.048,-190163.26)" fill="#2b0000" @@ -16418,8 +14077,7 @@ x="0.328125" y="14.5469" id="tspan1878" - style="fill:#000000">dUMP</tspan></text> - <text + style="fill:#000000">dUMP</tspan></text><text id="text7967-0-3-2-3" transform="rotate(0.808348,-28857.529,89246.093)" fill="#000000" @@ -16430,8 +14088,7 @@ letter-spacing="0em"><tspan x="0.160156" y="11.1602" - id="tspan1881">ADP</tspan></text> - <text + id="tspan1881">ADP</tspan></text><text id="text7967-0-3-1-6" transform="rotate(-0.829907,29385.126,-88505.134)" fill="#2b0000" @@ -16443,8 +14100,7 @@ x="0.27343801" y="11.1602" id="tspan1884" - style="fill:#000000">ATP</tspan></text> - <text + style="fill:#000000">ATP</tspan></text><text id="text7967-0-3-6-2-2-4" fill="#2b0000" xml:space="preserve" @@ -16456,8 +14112,7 @@ x="1458.22" y="405.547" id="tspan1887" - style="fill:#000000">dTMP</tspan></text> - <text + style="fill:#000000">dTMP</tspan></text><text id="text7967-0-3-2-4" transform="rotate(-0.416974,57898.223,-184605.41)" fill="#2b0000" @@ -16469,8 +14124,7 @@ x="0.30078101" y="11.1602" id="tspan1890" - style="fill:#000000">5,10meTHF</tspan></text> - <text + style="fill:#000000">5,10meTHF</tspan></text><text id="text7967-0-3-1-5" transform="rotate(0.26617,-88834.504,307398.67)" fill="#2b0000" @@ -16482,8 +14136,7 @@ x="0.160156" y="11.1602" id="tspan1893" - style="fill:#000000">DHF</tspan></text> - <text + style="fill:#000000">DHF</tspan></text><text id="text7967-0-3-6-2-0" fill="#000000" xml:space="preserve" @@ -16494,8 +14147,7 @@ letter-spacing="0em"><tspan x="1302.49" y="358.547" - id="tspan1896">UTP</tspan></text> - <text + id="tspan1896">UTP</tspan></text><text id="text7967-0-3-6-2-7-4" fill="#000000" xml:space="preserve" @@ -16506,8 +14158,7 @@ letter-spacing="0em"><tspan x="1440.49" y="358.547" - id="tspan1899">CTP</tspan></text> - <text + id="tspan1899">CTP</tspan></text><text id="text7967-0-3-65-1-3-2" fill="#2b0000" xml:space="preserve" @@ -16518,8 +14169,7 @@ x="1409.16" y="337.16" id="tspan1902" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text7967-0-3-65-1-3-2_2" fill="#2b0000" xml:space="preserve" @@ -16530,8 +14180,7 @@ x="1393.16" y="337.16" id="tspan1905" - style="fill:#000000">Pi</tspan></text> - <text + style="fill:#000000">Pi</tspan></text><text id="text7967-0-3-65-1-3-2-5" fill="#2b0000" xml:space="preserve" @@ -16542,11 +14191,9 @@ x="1336.27" y="337.16" id="tspan1908" - style="fill:#000000">ATP</tspan></text> - <g + style="fill:#000000">ATP</tspan></text><g id="text7967-0-3-65-1-3-2-5_2" - 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id="tspan1981">O</tspan></text> - </g> - <text + id="tspan1981">O</tspan></text></g><text id="text7967-0-3-0" fill="#000000" xml:space="preserve" @@ -16800,8 +14420,7 @@ letter-spacing="0em"><tspan x="1193.22" y="208.547" - id="tspan1986">AMP</tspan></text> - <text + id="tspan1986">AMP</tspan></text><text id="text7967-0-3-2-0" fill="#000000" xml:space="preserve" @@ -16811,8 +14430,7 @@ letter-spacing="0em"><tspan x="1166.16" y="166.16" - id="tspan1989">ADP</tspan></text> - <text + id="tspan1989">ADP</tspan></text><text id="text7967-0-3-9" fill="#000000" xml:space="preserve" @@ -16823,8 +14441,7 @@ letter-spacing="0em"><tspan x="1194.1" y="138.547" - id="tspan1992">ADP</tspan></text> - <text + id="tspan1992">ADP</tspan></text><text id="text7967-0-3-7" fill="#000000" xml:space="preserve" @@ -16834,10 +14451,8 @@ letter-spacing="0em"><tspan x="1166.27" y="180.16" - id="tspan1995">ATP</tspan></text> - <g - id="text7967-0-3-2-2"> - <text + id="tspan1995">ATP</tspan></text><g + id="text7967-0-3-2-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16850,8 +14465,7 @@ id="tspan1998">H</tspan><tspan x="1244.28" y="161.644" - 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id="tspan2059">2 Pi</tspan></text> - <path + id="tspan2059">2 Pi</tspan></text><path id="F_OMPDC" d="m 1111.62,340.747 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.6,-1.841 z m -20.26,0 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.61,-1.841 z m -24.93,0 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.61,-1.841 z m -37.4,0 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.43,7.259 1.6,-1.841 z M 1121,357 l 8,-3.5 -8,-3.5 2,3.5 z M 980.316,339.189 C 978.436,332 978.436,332 978.436,332 l -1.436,7.258 1.603,-1.84 z m 26.904,1.558 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.61,-1.841 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path d="m 1364.19,400.415 80.81,-0.108 m -74.72,9.809 c -2.83,-5.901 3.18,-9.765 3.18,-9.765 m 57.54,-0.026 c 8,1.175 9.5,9.175 9.5,9.175" stroke="#000000" stroke-width="1.95125" id="R_TMDS" - inkscape:label="R_TMDS" /> - <path + inkscape:label="R_TMDS" /><path id="B_TMDS" fill-rule="evenodd" clip-rule="evenodd" @@ -17106,8 +14691,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_TMDS" fill-rule="evenodd" clip-rule="evenodd" @@ -17115,8 +14699,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4125" transform="rotate(0.808348,-28686.836,108559.65)" fill="#2b0000" @@ -17128,8 +14711,7 @@ x="0.160156" y="11.1602" id="tspan2070" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text4129" transform="rotate(-0.829907,29494.126,-103555.33)" fill="#2b0000" @@ -17141,14 +14723,12 @@ x="0.27343801" y="11.1602" id="tspan2073" - style="fill:#000000">ATP</tspan></text> - <path + style="fill:#000000">ATP</tspan></text><path d="m 1516.45,400.415 24.35,0.11 m -18.27,9.747 c -2.82,-5.901 3.19,-9.765 3.19,-9.765 m 3.28,-0.045 c 5.26,0.759 5.04,9.322 5.04,9.322" stroke="#000000" stroke-width="1.95125" id="R_DTMPK" - inkscape:label="R_DTMPK" /> - <path + inkscape:label="R_DTMPK" /><path id="B_DTMPK" fill-rule="evenodd" clip-rule="evenodd" @@ -17156,8 +14736,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_DTMPK" fill-rule="evenodd" clip-rule="evenodd" @@ -17165,8 +14744,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4162" transform="rotate(0.808348,-22394.837,91002.335)" fill="#2b0000" @@ -17178,8 +14756,7 @@ x="0.160156" y="11.1602" id="tspan2083" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text4166" transform="rotate(-0.829907,23131.44,-86617.272)" fill="#000000" @@ -17190,21 +14767,18 @@ letter-spacing="0em"><tspan x="0.27343801" y="11.1602" - id="tspan2086">ATP</tspan></text> - <path + id="tspan2086">ATP</tspan></text><path d="m 1268.26,352.978 24.35,-0.111 m -18.27,-9.746 c -2.82,5.9 3.19,9.764 3.19,9.764 m 3.28,0.045 c 5.26,-0.759 5.04,-9.322 5.04,-9.322" stroke="#000000" stroke-width="1.95125" id="R_NDPK2" - inkscape:label="R_NDPK2" /> - <path + inkscape:label="R_NDPK2" /><path id="B_NDPK2" fill-rule="evenodd" clip-rule="evenodd" d="m 1275.62,344.538 c -1.83,-5.7 -1.83,-5.7 -1.83,-5.7 l -1.28,5.879 1.48,-1.537 z m -7.01,6.153 c -7.54,2.358 -7.54,2.358 -7.54,2.358 l 7.61,2.123 -1.93,-2.211 z" stroke="#000000" - stroke-width="1.95125" /> - <path + stroke-width="1.95125" /><path id="F_NDPK2" fill-rule="evenodd" clip-rule="evenodd" @@ -17212,8 +14786,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4194" transform="rotate(0.808348,-22319.07,105490.88)" fill="#2b0000" @@ -17225,8 +14798,7 @@ x="0.160156" y="11.1602" id="tspan2096" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text4198" transform="rotate(-0.829907,23236.989,-104251.01)" fill="#2b0000" @@ -17238,14 +14810,12 @@ x="0.27343801" y="11.1602" id="tspan2099" - style="fill:#000000">ATP</tspan></text> - <path + style="fill:#000000">ATP</tspan></text><path d="m 1485.19,352.976 41.17,-0.068 m -25.74,-9.768 c -2.82,5.901 3.19,9.765 3.19,9.765 m 6.39,0.044 c 5.27,-0.758 5.05,-9.321 5.05,-9.321" stroke="#000000" stroke-width="2.00453" id="R_NDPK3" - inkscape:label="R_NDPK3" /> - <path + inkscape:label="R_NDPK3" /><path id="B_NDPK3" fill-rule="evenodd" clip-rule="evenodd" @@ -17253,8 +14823,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_NDPK3" fill-rule="evenodd" clip-rule="evenodd" @@ -17262,14 +14831,12 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path d="m 1574,353.5 20,-0.095 m -12,0.057 c 7,-1.462 3.5,-9.462 3.5,-9.462" stroke="#000000" stroke-width="1.97845" id="R_RNDR3" - inkscape:label="R_RNDR3" /> - <path + inkscape:label="R_RNDR3" /><path id="F_RNDR3" fill-rule="evenodd" clip-rule="evenodd" @@ -17277,8 +14844,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4284" fill="#000000" xml:space="preserve" @@ -17288,8 +14854,7 @@ letter-spacing="0em"><tspan x="1174.16" y="262.16" - id="tspan2115">GTP</tspan></text> - <text + id="tspan2115">GTP</tspan></text><text id="text4288" fill="#000000" xml:space="preserve" @@ -17299,8 +14864,7 @@ letter-spacing="0em"><tspan x="1180.16" y="243.16" - id="tspan2118">Asp</tspan></text> - 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style="fill:#000000">⁺</tspan></text> - </g> - <g - id="text4339"> - <text + style="fill:#000000">⁺</tspan></text></g><g + id="text4339"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17377,8 +14933,7 @@ x="1293.28" y="265.16" id="tspan2141" - style="fill:#000000">O</tspan></text> - <text + style="fill:#000000">O</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17390,9 +14945,7 @@ x="1288.046" y="265.16" id="tspan2145" - style="fill:#000000">₂</tspan></text> - </g> - <text + style="fill:#000000">₂</tspan></text></g><text id="text4343" fill="#2b0000" xml:space="preserve" @@ -17403,10 +14956,8 @@ x="1311.27" y="265.16" id="tspan2150" - style="fill:#000000">ATP</tspan></text> - <g - id="text4347"> - <text + style="fill:#000000">ATP</tspan></text><g + id="text4347"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17417,8 +14968,7 @@ x="1343.3199" y="265.16" id="tspan2153" - style="fill:#000000">NH</tspan></text> - <text + style="fill:#000000">NH</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17429,9 +14979,7 @@ x="1360.67" y="265.16" id="tspan2157" - style="fill:#000000">₃</tspan></text> - </g> - <text + style="fill:#000000">₃</tspan></text></g><text id="text4371" fill="#2b0000" xml:space="preserve" @@ -17442,10 +14990,8 @@ x="1476.49" y="262.16" id="tspan2162" - style="fill:#000000">NADH</tspan></text> - <g - id="text4385"> - <text + style="fill:#000000">NADH</tspan></text><g + id="text4385"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17456,8 +15002,7 @@ x="1412.0601" y="262.16" id="tspan2165" - style="fill:#000000">H</tspan></text> - <text + style="fill:#000000">H</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17468,9 +15013,7 @@ x="1420.73" y="262.16" id="tspan2169" - style="fill:#000000">⁺</tspan></text> - </g> - <text + style="fill:#000000">⁺</tspan></text></g><text id="text4389" fill="#2b0000" xml:space="preserve" @@ -17481,8 +15024,7 @@ x="1439.5" y="262.16" id="tspan2174" - style="fill:#000000">AMP</tspan></text> - <text + style="fill:#000000">AMP</tspan></text><text id="text4393" fill="#2b0000" xml:space="preserve" @@ -17493,18 +15035,15 @@ x="1378.16" y="262.16" id="tspan2177" - style="fill:#000000">PPi</tspan></text> - <path + style="fill:#000000">PPi</tspan></text><path id="F_GMPS" fill-rule="evenodd" clip-rule="evenodd" d="m 1494.55,282.319 c 2.5,-0.838 5,-1.677 7.5,-2.515 -2.55,-0.655 -5.11,-1.309 -7.66,-1.964 0.66,0.724 1.32,1.447 1.98,2.171 -0.61,0.769 -1.21,1.538 -1.82,2.308 z M 1387.5,268 l -2.5,-3.5 -1.5,4 2,-1 z m 33,-0.5 -3,-3 -1,4.5 2,-1.5 z m 36,0.5 -3,-2.5 -1,4 1.5,-1.5 z m 31.02,4.737 c 1.06,-5.737 1.06,-5.737 1.06,-5.737 l -4.37,3.866 2.33,-0.265 z" fill="#2b0000" stroke="#000000" - stroke-width="1.95125" /> - <g - id="text4436"> - <text + stroke-width="1.95125" /><g + id="text4436"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17515,8 +15054,7 @@ x="1248.22" y="309.16" id="tspan2181" - style="fill:#000000">NADP</tspan></text> - 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inkscape:label="F_Transport_4abut_c_e" /> - <path + inkscape:label="F_Transport_4abut_c_e" /><path id="R_Transport_4abut_c_e" d="M 132,1078.06 H 59.7835" stroke="#000000" - stroke-width="1.72627" /> - <text + stroke-width="1.72627" /><text id="text7967-0-3-6-2-7-4-34-4-71-2-2-8-1-2-7-8-6" fill="#000000" xml:space="preserve" @@ -21841,9 +18761,7 @@ transform="scale(-1,1)"><tspan x="-188.37024" y="1082.55" - id="tspan353">4abut</tspan></text> - </g> - <text + id="tspan353">4abut</tspan></text></g><text id="text6041-8-4" fill="#000000" xml:space="preserve" @@ -21858,14 +18776,12 @@ x="69.488106" y="1181.1871" id="tspan1390-7-8" - style="stroke-width:0.997137">Lact/Glc</tspan></text> - <path + style="stroke-width:0.997137">Lact/Glc</tspan></text><path id="R_LactGlc" d="M 29.529936,1195.2341 H 108.5799" stroke="#000000" stroke-width="2.37931" - inkscape:label="R_LactGlc" /> - <text + inkscape:label="R_LactGlc" /><text id="text6041-8-3-8" fill="#000000" xml:space="preserve" @@ -21880,14 +18796,12 @@ x="70.885933" y="1254.2217" id="tspan1390-7-7-8" - style="stroke-width:0.997137">Lact/Gln</tspan></text> - <path + style="stroke-width:0.997137">Lact/Gln</tspan></text><path id="R_LactGln" d="M 30.926286,1268.3449 H 109.97625" stroke="#000000" stroke-width="2.37931" - inkscape:label="R_LactGln" /> - <text + inkscape:label="R_LactGln" /><text id="text6041-8-3-9-0" fill="#000000" xml:space="preserve" @@ -21902,14 +18816,12 @@ x="72.974266" y="1319.7736" id="tspan1390-7-7-7-6" - style="stroke-width:0.997137">Glu/Gln</tspan></text> - <path + style="stroke-width:0.997137">Glu/Gln</tspan></text><path id="R_GluGln" d="M 33.012426,1333.9653 H 112.06239" stroke="#000000" stroke-width="2.37931" - inkscape:label="R_GluGln" /> - <text + inkscape:label="R_GluGln" /><text id="text6041-8-3-9-2" fill="#000000" xml:space="preserve" @@ -21926,12 +18838,9 @@ id="tspan1390-7-7-7-9" style="stroke-width:0.997137">Lact/O<tspan style="font-size:65%;baseline-shift:sub" - id="tspan1-6">2</tspan></tspan></text> - <path + id="tspan1-6">2</tspan></tspan></text><path id="R_LactO2" d="M 32.716026,1399.7687 H 111.76598" stroke="#000000" stroke-width="2.37931" - 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inkscape:label="R_GACMTRc" /> - <path + inkscape:label="R_GACMTRc" /><path id="B_GACMTRc" d="m 379.969,1745.95 c -9.327,1.99 -9.327,1.99 -9.327,1.99 l 9.224,2.27 -2.268,-2.17 z m 13.455,13.24 c 3.277,9.61 3.277,9.61 3.277,9.61 l 2.47,-9.85 -2.773,2.55 z" fill="#2b0000" stroke="#000000" stroke-width="2.23952" - style="fill:none" /> - <text + style="fill:none" /><text id="text5420" fill="#000000" xml:space="preserve" @@ -2196,8 +1916,7 @@ letter-spacing="0em"><tspan x="361.461" y="1699.55" - id="tspan412">Creatine</tspan></text> - <text + id="tspan412">Creatine</tspan></text><text id="text5424" fill="#2b0000" xml:space="preserve" @@ -2208,8 +1927,7 @@ x="340.49799" y="1752.85" id="tspan415" - style="fill:#000000">SAM</tspan></text> - <text + style="fill:#000000">SAM</tspan></text><text id="text5428" fill="#2b0000" xml:space="preserve" @@ -2220,26 +1938,20 @@ x="341.16" y="1734.85" id="tspan418" - style="fill:#000000">SAH</tspan></text> - <g - id="Group 137"> - <path + style="fill:#000000">SAH</tspan></text><g + id="Group 137"><path id="F_CKc_cho" d="m 347.436,1699.13 c 9.563,-3.41 9.563,-3.41 9.563,-3.41 l -9.877,-2.34 2.587,2.74 z m 3.943,-13.53 c -1.994,-9.32 -1.994,-9.32 -1.994,-9.32 l -2.263,9.22 2.162,-2.27 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_CKc_cho" d="m 314,1696.35 35.572,-0.01 m 0,-12.34 c 0,0 0,12.34 -17.786,12.34 0,0 -17.786,0.01 -17.786,-12.34" stroke="#000000" - stroke-width="2.30969" /> - <path + stroke-width="2.30969" /><path id="B_CKc_cho" d="m 315.837,1693.82 c -9.607,3.27 -9.607,3.27 -9.607,3.27 l 9.845,2.47 -2.551,-2.77 z m 0.238,-8.82 c -1.994,-9.33 -1.994,-9.33 -1.994,-9.33 l -2.262,9.23 2.161,-2.27 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <text + stroke-width="2.23952" /></g><text id="text5438" fill="#000000" xml:space="preserve" @@ -2250,8 +1962,7 @@ letter-spacing="0em"><tspan x="231.125" y="1699.55" - id="tspan425">CreatineP</tspan></text> - <text + id="tspan425">CreatineP</tspan></text><text id="text5442" fill="#000000" xml:space="preserve" @@ -2261,8 +1972,7 @@ letter-spacing="0em"><tspan x="338.27301" y="1673.16" - id="tspan428">ATP</tspan></text> - <text + id="tspan428">ATP</tspan></text><text id="text5446" fill="#000000" xml:space="preserve" @@ -2272,20 +1982,17 @@ letter-spacing="0em"><tspan x="302.16" y="1673.16" - id="tspan431">ADP</tspan></text> - <path + id="tspan431">ADP</tspan></text><path id="R_CRTNsyn_cho" d="m 228,1681 c 0,14.5 -20.25,14.5 -20.25,14.5 -20.25,0 -20.25,-14.5 -20.25,-14.5 m 40.5,14.5 h -40.5" stroke="#000000" - stroke-width="2.30969" /> - <path + stroke-width="2.30969" /><path id="F_CRTNsyn_cho" fill-rule="evenodd" clip-rule="evenodd" d="m 185.672,1682.86 c 1.828,-9.36 1.828,-9.36 1.828,-9.36 l 2.426,9.18 -2.201,-2.23 z m 3.178,15.33 c -9.621,-3.23 -9.621,-3.23 -9.621,-3.23 l 9.833,-2.52 -2.538,2.78 z" stroke="#000000" - stroke-width="2.30969" /> - <text + stroke-width="2.30969" /><text id="text5458" fill="#000000" xml:space="preserve" @@ -2296,10 +2003,8 @@ letter-spacing="0em"><tspan x="96.343597" y="1699.55" - id="tspan436">Creatinine</tspan></text> - <g - id="text5464"> - <text + id="tspan436">Creatinine</tspan></text><g + id="text5464"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2309,8 +2014,7 @@ id="text441"><tspan x="224.062" y="1679.16" - id="tspan439">H</tspan></text> - 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stroke-width="2.49462" /> - <path + stroke-width="2.49462" /><path id="F_CRTNtr" fill-rule="evenodd" clip-rule="evenodd" d="m 55.2892,1693.93 3.0311,2.98 -12.296,-3.06 12.4107,-2.85 z" stroke="#000000" - stroke-width="2.62587" /> - <path + stroke-width="2.62587" /><path id="R_GUDACtr2" d="M 57,1780.5 H 381.5" stroke="#000000" - stroke-width="2.53856" /> - <path + stroke-width="2.53856" /><path id="F_GUDACtr2" fill-rule="evenodd" clip-rule="evenodd" d="m 58.2887,1780.93 3.0231,2.98 -12.2874,-3.05 12.4178,-2.86 z" stroke="#000000" - stroke-width="2.62587" /> - </g> - <g + stroke-width="2.62587" /></g><g id="path_glutathione" - transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"><g id="g34" - inkscape:label="box_glutathione"> - <path + inkscape:label="box_glutathione"><path id="Rectangle 3_9" d="m 2571,2212 v -108 c 0,-6.63 -5.37,-12 -12,-12 H 2522.77 2109 c -6.63,0 -12,5.37 -12,12 v 108 c 0,6.63 5.37,12 12,12 h 450 c 6.63,0 12,-5.37 12,-12 z" fill="#aeaeae" - fill-opacity="0.1" /> - <path + fill-opacity="0.1" /><path id="Rectangle 2_9" d="M 2350.2145,2079 H 2546.5 c 6.63,0 12,5.37 12,12 v 109 c 0,6.63 -5.37,12 -12,12 H 2097 c -6.63,0 -12,-5.37 -12,-12 v -109 c 0,-6.63 5.37,-12 12,-12 h 8.5" stroke="#aeaeae" stroke-width="4" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_9" fill="#000000" xml:space="preserve" @@ -2400,17 +2090,13 @@ letter-spacing="0em"><tspan x="2114" y="2085.4299" - id="tspan763">Glutathione synthesis</tspan></text> - <circle + id="tspan763">Glutathione synthesis</tspan></text><circle id="Ellipse 1_9" cx="2350.0625" cy="2079" r="6" - fill="#aeaeae" /> - </g> - <g - id="Group 135"> - <text + fill="#aeaeae" /></g><g + id="Group 135"><text id="text3860-8" fill="#000000" xml:space="preserve" @@ -2421,8 +2107,7 @@ letter-spacing="0em"><tspan x="2112.3799" y="2139.55" - id="tspan788">GSSG</tspan></text> - <text + id="tspan788">GSSG</tspan></text><text id="text3860-8-1" fill="#000000" xml:space="preserve" @@ -2435,10 +2120,8 @@ y="141.89951"><tspan x="2103.3118" y="2281.4497" - id="tspan788-2">GSSG</tspan></text> - <g - id="Group 130"> - <text + id="tspan788-2">GSSG</tspan></text><g + id="Group 130"><text id="text7967-0-3-9-1-8-0-3" fill="#000000" xml:space="preserve" @@ -2449,8 +2132,7 @@ letter-spacing="0em"><tspan x="2267.1599" y="2138.55" - id="tspan791">GSH</tspan></text> - <text + id="tspan791">GSH</tspan></text><text id="text7967-0-3-9-1-8-0-3-6" fill="#000000" xml:space="preserve" @@ -2463,15 +2145,12 @@ y="147.07513"><tspan x="2271.7202" y="2285.6252" - id="tspan791-2">GSH</tspan></text> - <path + id="tspan791-2">GSH</tspan></text><path id="F_GTHPi" d="m 2172.55,2133.74 c -9.67,-3.1 -9.67,-3.1 -9.67,-3.1 l 9.8,-2.65 -2.5,2.82 z m 9.08,-11.56 c 2.85,-6.57 2.85,-6.57 2.85,-6.57 l 2.67,6.61 -2.74,-1.67 z" stroke="#000000" - stroke-width="1.90098" /> - <g - id="text3878-1"> - <text + stroke-width="1.90098" /><g + id="text3878-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2481,8 +2160,7 @@ id="text797"><tspan x="2191.0601" y="2154.1599" - id="tspan795">H</tspan></text> - <text + id="tspan795">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2492,9 +2170,7 @@ id="text801"><tspan x="2199.73" y="2154.1599" - id="tspan799">⁺</tspan></text> - </g> - <text + id="tspan799">⁺</tspan></text></g><text id="text3878-1_2" fill="#000000" xml:space="preserve" @@ -2504,10 +2180,8 @@ letter-spacing="0em"><tspan x="2147.49" y="2154.1599" - id="tspan804">NADH</tspan></text> - <g - id="text3882-4"> - <text + id="tspan804">NADH</tspan></text><g + id="text3882-4"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2517,8 +2191,7 @@ id="text809"><tspan x="2207.22" y="2160.1599" - id="tspan807">NAD</tspan></text> - <text + id="tspan807">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2528,11 +2201,8 @@ id="text813"><tspan x="2232.5701" y="2160.1599" - id="tspan811">⁺</tspan></text> - </g> - <g - id="text3902-2"> - <text + id="tspan811">⁺</tspan></text></g><g + id="text3902-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2545,8 +2215,7 @@ id="tspan816">H</tspan><tspan x="2224.27" y="2117.1599" - id="tspan818">O</tspan></text> - <text + id="tspan818">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2559,9 +2228,7 @@ id="tspan822">₂</tspan><tspan x="2233.6101" y="2117.1599" - id="tspan824">₂</tspan></text> - </g> - <text + id="tspan824">₂</tspan></text></g><text id="text3910-9" fill="#000000" xml:space="preserve" @@ -2571,15 +2238,12 @@ letter-spacing="0em"><tspan x="2243.49" y="2117.1599" - id="tspan829">GSH</tspan></text> - <path + id="tspan829">GSH</tspan></text><path id="R_GTHPi" d="m 2205.5,2130.96 c 17,0.09 17,-9.96 17,-9.96 m 36.6,10.22 -89.59,-0.43 m 69.49,0.34 c 16,0.07 16,-10.13 16,-10.13 m -70.5,0 c 0,9.86 21.41,9.96 21.41,9.96" stroke="#000000" - stroke-width="2.38381" /> - <g - id="text3929-9"> - <text + stroke-width="2.38381" /><g + id="text3929-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2592,8 +2256,7 @@ id="tspan833">2 H</tspan><tspan x="2191.29" y="2112.1599" - id="tspan835">O</tspan></text> - <text + id="tspan835">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2603,9 +2266,7 @@ id="text841"><tspan x="2187.0601" y="2112.1599" - id="tspan839">₂</tspan></text> - </g> - <text + id="tspan839">₂</tspan></text></g><text id="text3964-2" fill="#000000" xml:space="preserve" @@ -2615,21 +2276,16 @@ letter-spacing="0em"><tspan x="2241.49" y="2160.1599" - id="tspan844">GSH</tspan></text> - <path + id="tspan844">GSH</tspan></text><path id="R_GDR" d="m 2213.5,2137.98 c 10,0 10,5.02 10,5.02 m -60.5,-5.02 c 0,0 9.45,0 15.5,0 m 78,0 c 0,0 -47.54,0 -78,0 m 61,0 c 10.5,0 10.5,5.02 10.5,5.02 m -45,-5.02 c -9.5,0 -9.5,5.02 -9.5,5.02 m -17,-5.02 c -15.5,0 -15.5,5.02 -15.5,5.02" stroke="#000000" - stroke-width="1.39417" /> - <path + stroke-width="1.39417" /><path id="F_GDR" d="m 2220.22,2141.87 c 2.85,6.57 2.85,6.57 2.85,6.57 l 2.67,-6.61 -2.74,1.67 z m 27,0.5 c 2.85,6.57 2.85,6.57 2.85,6.57 l 2.67,-6.61 -2.74,1.67 z m 7.53,-1.29 c 9.66,-3.1 9.66,-3.1 9.66,-3.1 l -9.79,-2.65 2.5,2.82 z" stroke="#000000" - stroke-width="1.90098" /> - </g> - <g - id="text3999-9"> - <text + stroke-width="1.90098" /></g><g + id="text3999-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2639,8 +2295,7 @@ id="text852"><tspan x="2221.22" y="2198.1599" - id="tspan850">NADP</tspan></text> - <text + id="tspan850">NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2650,9 +2305,7 @@ id="text856"><tspan x="2254.5701" y="2198.1599" - id="tspan854">⁺</tspan></text> - </g> - <text + id="tspan854">⁺</tspan></text></g><text id="text4005-9" fill="#000000" xml:space="preserve" @@ -2662,15 +2315,12 @@ letter-spacing="0em"><tspan x="2264.49" y="2198.1599" - id="tspan859">GSH</tspan></text> - <path + id="tspan859">GSH</tspan></text><path id="R_GTHOr" d="m 2235.5,2173 c 5.9,0.99 5.5,8.99 5.5,8.99 m 33.48,-8.99 c 5.9,0.99 5.52,8.99 5.52,8.99 M 2135.5,2143.5 V 2173 H 2282 v -28 m -83,28 c -7.95,1.72 -7,8.99 -7,8.99 m -39,-8.99 c -7.95,1.72 -7,8.99 -7,8.99" stroke="#000000" - stroke-width="1.39417" /> - <g - id="text4017-2"> - <text + stroke-width="1.39417" /><g + id="text4017-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2680,8 +2330,7 @@ id="text865"><tspan x="2141.0601" y="2193.1599" - id="tspan863">H</tspan></text> - <text + id="tspan863">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -2691,9 +2340,7 @@ id="text869"><tspan x="2149.73" y="2193.1599" - id="tspan867">⁺</tspan></text> - </g> - <text + id="tspan867">⁺</tspan></text></g><text id="text4017-2_2" fill="#000000" xml:space="preserve" @@ -2703,44 +2350,34 @@ letter-spacing="0em"><tspan x="2169.49" y="2193.1599" - id="tspan872">NADPH</tspan></text> - <path + id="tspan872">NADPH</tspan></text><path id="F_GTHOr" d="m 2284.93,2152.37 c -3.1,-9.67 -3.1,-9.67 -3.1,-9.67 l -2.65,9.8 2.82,-2.5 z m -46.95,28.17 c 2.85,6.57 2.85,6.57 2.85,6.57 l 2.67,-6.61 -2.74,1.67 z m 39.24,-1.17 c 2.85,6.57 2.85,6.57 2.85,6.57 l 2.67,-6.61 -2.74,1.67 z" stroke="#000000" - stroke-width="1.90098" /> - <g - id="Group 131"> - <path + stroke-width="1.90098" /><g + id="Group 131"><path id="R_DmGSSG" d="M 2128,2256.5 V 2143" stroke="#000000" - stroke-width="2.50699" /> - <path + stroke-width="2.50699" /><path id="F_DmGSSG" fill-rule="evenodd" clip-rule="evenodd" d="m 2128.01,2255.67 -3.01,-3 3.17,12.27 2.74,-12.44 z" stroke="#000000" stroke-width="2.62587" - inkscape:label="F_DmGSSG" /> - </g> - <g - id="Group 132"> - <path + inkscape:label="F_DmGSSG" /></g><g + id="Group 132"><path id="R_GTHRDt2" d="M 2296.25,2152.65 V 2266.5" stroke="#000000" - stroke-width="2.50699" /> - <path + stroke-width="2.50699" /><path id="F_GTHRDt2" fill-rule="evenodd" clip-rule="evenodd" d="m 2296.01,2150.26 -3.01,3.01 3.17,-12.27 2.74,12.44 z" stroke="#000000" - stroke-width="2.62587" /> - </g> - <text + stroke-width="2.62587" /></g><text id="text7967-0-3-9-1-5-9" fill="#000000" xml:space="preserve" @@ -2751,8 +2388,7 @@ letter-spacing="0em"><tspan x="2395.49" y="2138.55" - id="tspan882">GC</tspan></text> - <text + id="tspan882">GC</tspan></text><text id="text5921" fill="#000000" xml:space="preserve" @@ -2763,10 +2399,8 @@ letter-spacing="0em"><tspan x="2515.3101" y="2138.55" - id="tspan885">Cys</tspan></text> - <g - id="Group 133"> - <text + id="tspan885">Cys</tspan></text><g + id="Group 133"><text id="text7967-0-3-7-5-8-7-2-7" fill="#000000" xml:space="preserve" @@ -2776,18 +2410,15 @@ letter-spacing="0em"><tspan x="2383.27" y="2123.1599" - id="tspan888">ATP</tspan></text> - <path + id="tspan888">ATP</tspan></text><path id="R_GTHS" d="m 2317,2134.06 h 42.5 m 33,0 h -33 m -10,-9.06 c 0,9.06 10,9.06 10,9.06 m 0,0 c 0,0 9,0 9,-9.06 m -36,9.06 c -9.5,0 -9.5,-9.06 -9.5,-9.06 m 69.5,0 c 0,9.06 -9,9.06 -9,9.06" stroke="#000000" - stroke-width="1.68137" /> - <path + stroke-width="1.68137" /><path id="F_GTHS" d="m 2320.65,2126.2 c 2.35,-9.24 2.35,-9.24 2.35,-9.24 l 1.9,9.3 -2.07,-2.35 z m -1.86,10.75 c -3.26,-0.89 -6.53,-1.78 -9.79,-2.68 3.22,-1.02 6.45,-2.04 9.67,-3.07 -0.79,0.98 -1.58,1.95 -2.37,2.93 0.83,0.94 1.66,1.88 2.49,2.82 z" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-3-7-5-8-7-2-7-8" fill="#000000" xml:space="preserve" @@ -2797,8 +2428,7 @@ letter-spacing="0em"><tspan x="2360.49" y="2123.1599" - id="tspan893">Gly</tspan></text> - <text + id="tspan893">Gly</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7" fill="#000000" xml:space="preserve" @@ -2808,8 +2438,7 @@ letter-spacing="0em"><tspan x="2343.1599" y="2116.1599" - id="tspan896">Pi</tspan></text> - <text + id="tspan896">Pi</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7_2" fill="#000000" xml:space="preserve" @@ -2819,11 +2448,8 @@ letter-spacing="0em"><tspan x="2312.1599" y="2114.1599" - id="tspan899">ADP</tspan></text> - </g> - <g - id="Group 134"> - <text + id="tspan899">ADP</tspan></text></g><g + id="Group 134"><text id="text7967-0-3-7-5-8-7-2-7_2" fill="#000000" xml:space="preserve" @@ -2833,18 +2459,15 @@ letter-spacing="0em"><tspan x="2501.27" y="2123.1599" - id="tspan903">ATP</tspan></text> - <path + id="tspan903">ATP</tspan></text><path id="R_GLUCYS" d="m 2435,2134.06 h 42.5 m 33,0 h -33 m -10,-9.06 c 0,9.06 10,9.06 10,9.06 m 0,0 c 0,0 9,0 9,-9.06 m -36,9.06 c -9.5,0 -9.5,-9.06 -9.5,-9.06 m 69.5,0 c 0,9.06 -9,9.06 -9,9.06" stroke="#000000" - stroke-width="1.68137" /> - <path + stroke-width="1.68137" /><path id="F_GLUCYS" d="m 2438.65,2126.2 c 2.35,-9.24 2.35,-9.24 2.35,-9.24 l 1.9,9.3 -2.07,-2.35 z m -1.86,10.75 c -3.26,-0.89 -6.53,-1.78 -9.79,-2.68 3.22,-1.02 6.45,-2.04 9.67,-3.07 -0.79,0.98 -1.58,1.95 -2.37,2.93 0.83,0.94 1.66,1.88 2.49,2.82 z" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-3-7-5-8-7-2-7-8_2" fill="#000000" xml:space="preserve" @@ -2854,8 +2477,7 @@ letter-spacing="0em"><tspan x="2478.1499" y="2123.1599" - id="tspan908">Glu</tspan></text> - <text + id="tspan908">Glu</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7_3" fill="#000000" xml:space="preserve" @@ -2865,8 +2487,7 @@ letter-spacing="0em"><tspan x="2461.1599" y="2116.1599" - id="tspan911">Pi</tspan></text> - <text + id="tspan911">Pi</tspan></text><text id="text7967-0-3-7-5-8-7-2-7-7_4" fill="#000000" xml:space="preserve" @@ -2876,30 +2497,22 @@ letter-spacing="0em"><tspan x="2430.1599" y="2114.1599" - id="tspan914">ADP</tspan></text> - </g> - </g> - </g> - <g + id="tspan914">ADP</tspan></text></g></g></g><g id="path_biomass" - transform="matrix(0.99609327,0,0,0.99818223,7.6974935,404.18463)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,7.6974935,404.18463)"><g id="g33" - inkscape:label="box_biomass"> - <path + inkscape:label="box_biomass"><path id="Rectangle 3_7" d="m 2548.5663,1564.9748 v -542 c 0,-6.63 -5.2478,-12 -11.727,-12 h -42.6572 -468.4472 c -6.4792,0 -11.7271,5.37 -11.7271,12 v 542 c 0,6.63 5.2479,12 11.7271,12 h 511.1044 c 6.4792,0 11.727,-5.37 11.727,-12 z" fill="#f018ce" fill-opacity="0.1" - style="stroke-width:0.988562" /> - <path + style="stroke-width:0.988562" /><path id="Rectangle 2_7" d="m 2145.7441,1011.9698 h 389.6473 c 6.4304,0 11.6388,5.3706 11.6388,12.0013 v 543.0578 c 0,6.6307 -5.2084,12.0013 -11.6388,12.0013 H 2028.132 c -6.4305,0 -11.6389,-5.3706 -11.6389,-12.0013 v -543.0578 c 0,-6.6307 5.2084,-12.0013 11.6389,-12.0013 h 8.2442" stroke="#f018ce" stroke-width="3.93956" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_7" fill="#000000" xml:space="preserve" @@ -2912,17 +2525,13 @@ y="-0.51527369"><tspan x="2039.8434" y="1017.9147" - id="tspan749">Biomass</tspan></text> - <circle + id="tspan749">Biomass</tspan></text><circle id="Ellipse 1_7" cx="2133.0391" cy="1012" r="6" - fill="#f018ce" /> - </g> - <g - id="Group 32"> - <text + fill="#f018ce" /></g><g + id="Group 32"><text id="text5640-6" fill="#2b0000" xml:space="preserve" @@ -2933,8 +2542,7 @@ x="2034.53" y="1290.37" id="tspan4670" - style="fill:#000000">0.01 dTTP</tspan></text> - <text + style="fill:#000000">0.01 dTTP</tspan></text><text id="text5562-2" fill="#2b0000" xml:space="preserve" @@ -2945,8 +2553,7 @@ x="2033.84" y="1209.63" id="tspan4673" - style="fill:#000000">0.01 dATP</tspan></text> - <text + style="fill:#000000">0.01 dATP</tspan></text><text id="text5543-5" fill="#2b0000" xml:space="preserve" @@ -2957,8 +2564,7 @@ x="2031.09" y="1263.46" id="tspan4676" - style="fill:#000000">0.01 dGTP</tspan></text> - <text + style="fill:#000000">0.01 dGTP</tspan></text><text id="text7967-0-3-6-2-0-0" fill="#2b0000" xml:space="preserve" @@ -2969,8 +2575,7 @@ x="2042.22" y="1182.1899" id="tspan4679" - style="fill:#000000">0.05 UTP</tspan></text> - <text + style="fill:#000000">0.05 UTP</tspan></text><text id="text5590-1" fill="#2b0000" xml:space="preserve" @@ -2981,8 +2586,7 @@ x="2032.47" y="1236.55" id="tspan4682" - style="fill:#000000">0.01 dCTP</tspan></text> - <text + style="fill:#000000">0.01 dCTP</tspan></text><text id="text7967-0-3-6-2-7-4-6" fill="#2b0000" xml:space="preserve" @@ -2993,8 +2597,7 @@ x="2048.21" y="1155.49" id="tspan4685" - style="fill:#000000">0.04CTP</tspan></text> - <text + style="fill:#000000">0.04CTP</tspan></text><text id="text7967-0-5-1-1" fill="#2b0000" xml:space="preserve" @@ -3005,8 +2608,7 @@ x="2034.42" y="1331.8199" id="tspan4688" - style="fill:#000000">0.27 Palm</tspan></text> - <text + style="fill:#000000">0.27 Palm</tspan></text><text id="text7967-0-8" fill="#2b0000" xml:space="preserve" @@ -3017,10 +2619,8 @@ x="2037.84" y="1357.36" id="tspan4691" - style="fill:#000000">0.20 Chol</tspan></text> - <g - id="a14389-3"> - <text + style="fill:#000000">0.20 Chol</tspan></text><g + id="a14389-3"><text id="text6883-6" fill="#2b0000" xml:space="preserve" @@ -3031,11 +2631,8 @@ x="2041.97" y="1394.83" id="tspan4694" - style="fill:#000000">0.28 G6P</tspan></text> - </g> - <g - id="a14389-3-9"> - <text + style="fill:#000000">0.28 G6P</tspan></text></g><g + id="a14389-3-9"><text id="text6883-6-8" fill="#2b0000" xml:space="preserve" @@ -3046,8 +2643,7 @@ x="2031" y="1419.7" id="tspan4698" - style="fill:#000000">20.65 H20</tspan></text> - <text + style="fill:#000000">20.65 H20</tspan></text><text id="text6883-6-8-0" fill="#2b0000" xml:space="preserve" @@ -3058,9 +2654,7 @@ x="2032.34" y="1443.1899" id="tspan4701" - style="fill:#000000">20.70 ATP</tspan></text> - </g> - <text + style="fill:#000000">20.70 ATP</tspan></text></g><text id="text4694-5" fill="#2b0000" xml:space="preserve" @@ -3071,8 +2665,7 @@ x="2043.4" y="1128.58" id="tspan4705" - style="fill:#000000">0.04 GTP</tspan></text> - <text + style="fill:#000000">0.04 GTP</tspan></text><text id="text5640-6-2" fill="#2b0000" xml:space="preserve" @@ -3083,8 +2676,7 @@ x="2448.8" y="1177.9" id="tspan4708" - style="fill:#000000">0.36 Arg</tspan></text> - <text + style="fill:#000000">0.36 Arg</tspan></text><text id="text5562-2-6" fill="#2b0000" xml:space="preserve" @@ -3095,8 +2687,7 @@ x="2448.1001" y="1248.71" id="tspan4711" - style="fill:#000000">0.05 Cys</tspan></text> - <text + style="fill:#000000">0.05 Cys</tspan></text><text id="text5543-5-4" fill="#2b0000" xml:space="preserve" @@ -3107,8 +2698,7 @@ x="2448.1001" y="1319.61" id="tspan4714" - style="fill:#000000">0.39 Glu</tspan></text> - <text + style="fill:#000000">0.39 Glu</tspan></text><text id="text7967-0-3-6-2-0-0-7" fill="#2b0000" xml:space="preserve" @@ -3119,8 +2709,7 @@ x="2448.8" y="1224.96" id="tspan4717" - style="fill:#000000">0.35 Asp</tspan></text> - <text + style="fill:#000000">0.35 Asp</tspan></text><text id="text5590-1-2" fill="#2b0000" xml:space="preserve" @@ -3131,8 +2720,7 @@ x="2448.1001" y="1296.08" id="tspan4720" - style="fill:#000000">0.33 Gln</tspan></text> - <text + style="fill:#000000">0.33 Gln</tspan></text><text id="text7967-0-3-6-2-7-4-6-0" fill="#2b0000" xml:space="preserve" @@ -3143,8 +2731,7 @@ x="2448.8" y="1201.4301" id="tspan4723" - style="fill:#000000">0.28 Asn</tspan></text> - <text + style="fill:#000000">0.28 Asn</tspan></text><text id="text7967-0-5-1-1-1" fill="#2b0000" xml:space="preserve" @@ -3155,8 +2742,7 @@ x="2097.46" y="1489.5699" id="tspan4726" - style="fill:#000000">0.29 Ile</tspan></text> - <text + style="fill:#000000">0.29 Ile</tspan></text><text id="text7967-0-8-1" fill="#2b0000" xml:space="preserve" @@ -3167,8 +2753,7 @@ x="2096.72" y="1466.76" id="tspan4729" - style="fill:#000000">0.12 His</tspan></text> - <text + style="fill:#000000">0.12 His</tspan></text><text id="text6883-6-0" fill="#2b0000" xml:space="preserve" @@ -3179,8 +2764,7 @@ x="2448.1001" y="1272.55" id="tspan4732" - style="fill:#000000">0.54 Gly</tspan></text> - <text + style="fill:#000000">0.54 Gly</tspan></text><text id="text5640-6-2-3" fill="#2b0000" xml:space="preserve" @@ -3191,8 +2775,7 @@ x="2172.45" y="1546.84" id="tspan4735" - style="fill:#000000">0.59Lys</tspan></text> - <text + style="fill:#000000">0.59Lys</tspan></text><text id="text7967-0-3-6-2-0-0-7-5" fill="#2b0000" xml:space="preserve" @@ -3203,8 +2786,7 @@ x="2447.4299" y="1342.62" id="tspan4738" - style="fill:#000000">0.41 Pro</tspan></text> - <text + style="fill:#000000">0.41 Pro</tspan></text><text id="text7967-0-3-6-2-0-0-7-5-7" fill="#2b0000" xml:space="preserve" @@ -3215,8 +2797,7 @@ x="2389.76" y="1489.92" id="tspan4741" - style="fill:#000000">0.26 Phe</tspan></text> - <text + style="fill:#000000">0.26 Phe</tspan></text><text id="text7967-0-3-6-2-7-4-6-0-8" fill="#2b0000" xml:space="preserve" @@ -3227,8 +2808,7 @@ x="2389.77" y="1471.21" id="tspan4744" - style="fill:#000000">0.15 Met</tspan></text> - <text + style="fill:#000000">0.15 Met</tspan></text><text id="text4694-5-1-8" fill="#2b0000" xml:space="preserve" @@ -3239,8 +2819,7 @@ x="2097.05" y="1508.79" id="tspan4747" - style="fill:#000000">0.55 Leu</tspan></text> - <text + style="fill:#000000">0.55 Leu</tspan></text><text id="text5640-6-2-3-7" fill="#2b0000" xml:space="preserve" @@ -3251,8 +2830,7 @@ x="2326.96" y="1547.46" id="tspan4750" - style="fill:#000000">0.01 Trp</tspan></text> - <text + style="fill:#000000">0.01 Trp</tspan></text><text id="text7967-0-3-6-2-0-0-7-5-4" fill="#2b0000" xml:space="preserve" @@ -3263,8 +2841,7 @@ x="2391.01" y="1510.1" id="tspan4753" - style="fill:#000000">0.31Thr</tspan></text> - <text + style="fill:#000000">0.31Thr</tspan></text><text id="text7967-0-3-6-2-7-4-6-0-8-0" fill="#2b0000" xml:space="preserve" @@ -3275,8 +2852,7 @@ x="2449.01" y="1389.6801" id="tspan4756" - style="fill:#000000">0.16 Tyr</tspan></text> - <text + style="fill:#000000">0.16 Tyr</tspan></text><text id="text7967-0-3-6-2-7-4-6-0-8-0-4" fill="#2b0000" xml:space="preserve" @@ -3287,8 +2863,7 @@ x="2252.9199" y="1548.21" id="tspan4759" - style="fill:#000000">0.35Val</tspan></text> - <text + style="fill:#000000">0.35Val</tspan></text><text id="text4694-5-1-8-1" fill="#2b0000" xml:space="preserve" @@ -3299,8 +2874,7 @@ x="2447.95" y="1366.36" id="tspan4762" - style="fill:#000000">0.39 Ser</tspan></text> - <text + style="fill:#000000">0.39 Ser</tspan></text><text id="text4694-5-1" fill="#2b0000" xml:space="preserve" @@ -3311,8 +2885,7 @@ x="2448.8" y="1154.9" id="tspan4765" - style="fill:#000000">0.51 Ala</tspan></text> - <text + style="fill:#000000">0.51 Ala</tspan></text><text id="text11603-4-6" fill="#000000" xml:space="preserve" @@ -3323,8 +2896,7 @@ letter-spacing="0em"><tspan x="2232.73" y="1058.27" - id="tspan4768">Biomass</tspan></text> - <text + id="tspan4768">Biomass</tspan></text><text id="text11603-4-6-6" fill="#000000" xml:space="preserve" @@ -3334,8 +2906,7 @@ letter-spacing="0em"><tspan x="2390.53" y="1080.3101" - id="tspan4771">20.65 Pi</tspan></text> - <text + id="tspan4771">20.65 Pi</tspan></text><text id="text11603-4-6-6-0" fill="#000000" xml:space="preserve" @@ -3345,8 +2916,7 @@ letter-spacing="0em"><tspan x="2098.0601" y="1099.96" - 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inkscape:label="R_Biomass" /> - <path + inkscape:label="R_Biomass" /><path id="F_Biomass" d="m 2278.69,1068.05 -3.15,9.65 2.95,-2.35 2.8,2.51 z m 96.17,5.2 2.35,2.94 -2.52,2.81 9.81,-2.6 z m -180.3,20.63 -9.81,2.6 9.65,3.15 -2.35,-2.95 z m 182.25,8.74 2.35,2.95 -2.52,2.8 9.82,-2.6 z" stroke="#000000" - stroke-width="2.66667" /> - </g> - </g> - <g + stroke-width="2.66667" /></g></g><g id="path_cholesterol_synthesis" - transform="matrix(0.99609327,0,0,0.99818223,-21.287566,49.704866)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,-21.287566,49.704866)"><g id="g38" - inkscape:label="box_cholesterol_synthesis"> - <path + inkscape:label="box_cholesterol_synthesis"><path id="Rectangle 3_4" d="m 2357.9532,963.97816 v -246 c 0,-6.627 -5.37,-12 -12,-12 h -75.4 -759.6 c -6.63,0 -12,5.373 -12,12 v 246 c 0,6.627 5.37,12 12,12 h 835 c 6.63,0 12,-5.373 12,-12 z" fill="#cbe048" - fill-opacity="0.1" /> - <path + fill-opacity="0.1" /><path id="Rectangle 2_4" d="M 1884.8015,705 H 2345.5 c 6.63,0 12,5.373 12,12 v 246.5 c 0,6.627 -5.37,12 -12,12 H 1511 c -6.63,0 -12,-5.373 -12,-12 V 717 c 0,-6.627 5.37,-12 12,-12 h 8.5" stroke="#cbe048" stroke-width="4" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_4" fill="#000000" xml:space="preserve" @@ -3401,17 +2962,13 @@ letter-spacing="0em"><tspan x="1528" y="711.43402" - id="tspan728">Fatty acids / Cholesterol synthesis</tspan></text> - <circle + id="tspan728">Fatty acids / Cholesterol synthesis</tspan></text><circle id="Ellipse 1_4" cx="1885.0625" cy="705" r="6" - fill="#cbe048" /> - </g> - <g - id="Group 25"> - <text + fill="#cbe048" /></g><g + id="Group 25"><text id="text6997-5-1-8-3-7-8" fill="#000000" xml:space="preserve" @@ -3421,10 +2978,8 @@ letter-spacing="0em"><tspan x="1691.27" y="881.15997" - id="tspan2277">ATP</tspan></text> - <g - id="text6997-5-1-8-3-71-4"> - <text + id="tspan2277">ATP</tspan></text><g + id="text6997-5-1-8-3-71-4"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3434,8 +2989,7 @@ id="text2282"><tspan x="1747.35" y="881.15997" - id="tspan2280">HCO</tspan></text> - <text + id="tspan2280">HCO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3445,8 +2999,7 @@ id="text2286"><tspan x="1778.25" y="881.15997" - id="tspan2284">⁻</tspan></text> - <text + id="tspan2284">⁻</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3456,11 +3009,8 @@ id="text2290"><tspan x="1774.03" y="881.15997" - id="tspan2288">₃</tspan></text> - </g> - <g - id="text6997-5-1-8-3-71-2-9"> - <text + id="tspan2288">₃</tspan></text></g><g + id="text6997-5-1-8-3-71-2-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3470,8 +3020,7 @@ id="text2295"><tspan x="1725.0601" y="881.15997" - id="tspan2293">H</tspan></text> - <text + id="tspan2293">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3481,9 +3030,7 @@ id="text2299"><tspan x="1733.73" y="881.15997" - id="tspan2297">⁺</tspan></text> - </g> - <text + id="tspan2297">⁺</tspan></text></g><text id="text6997-5-1-8-3-71-5-72" fill="#000000" xml:space="preserve" @@ -3493,8 +3040,7 @@ letter-spacing="0em"><tspan x="1718.16" y="845.15997" - id="tspan2302">ADP</tspan></text> - <text + id="tspan2302">ADP</tspan></text><text id="text6997-5-1-8-3-71-5-7-37" fill="#000000" xml:space="preserve" @@ -3504,20 +3050,16 @@ letter-spacing="0em"><tspan x="1750.16" y="845.15997" - id="tspan2305">Pi</tspan></text> - <path + id="tspan2305">Pi</tspan></text><path id="R_ACCOAC" d="m 1707.68,858.5 c -5.18,0 -5.18,11.5 -5.18,11.5 m 25.5,-9.981 c 5,0 4.22,-6.671 4.22,-6.671 m 20.53,6.671 c 4.25,0 1.75,-6.667 1.75,-6.667 m -17.5,6.667 c 0,0 -18.51,0.241 -20.5,0 -55,-6.667 -232,-10.519 -232,-10.519 m 252.5,10.519 h 31.5 m -31.5,0 c -6.5,0 -6.5,9.981 -6.5,9.981 m 31.5,-9.981 c -5,0 -5,9.981 -5,9.981" stroke="#000000" - stroke-width="2.097" /> - <path + stroke-width="2.097" /><path id="F_ACCOAC" d="m 1767.2,861.406 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z m -33.74,-7.811 C 1732,848 1732,848 1732,848 l -1.12,5.649 1.25,-1.432 z m 21.87,0.783 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 L 1754,853 Z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="Group 75"> - <text + stroke-width="2.23952" /><g + id="Group 75"><text id="text6997-5-1-8-3-7-7-3-7-2-2" fill="#000000" xml:space="preserve" @@ -3527,8 +3069,7 @@ letter-spacing="0em"><tspan x="1779.3199" y="797.15997" - id="tspan2310">CoA</tspan></text> - <text + id="tspan2310">CoA</tspan></text><text id="text7967-8-1-7" fill="#000000" xml:space="preserve" @@ -3539,8 +3080,7 @@ letter-spacing="0em"><tspan x="1814.37" y="817.547" - id="tspan2313">AcACP</tspan></text> - <text + id="tspan2313">AcACP</tspan></text><text id="text6997-5-1-8-3-71-2-5-43-4-1-0" fill="#000000" xml:space="preserve" @@ -3550,23 +3090,17 @@ letter-spacing="0em"><tspan x="1769.16" y="832.15997" - id="tspan2316">ACP</tspan></text> - <path + id="tspan2316">ACP</tspan></text><path id="R_FASN" d="m 1785.42,813.498 c -3.74,0.857 -3.42,7.211 -3.42,7.211 m 7.32,-7.328 c 3.69,-0.812 2.75,-7.672 2.75,-7.672 M 1484.5,845 c 220,-35 321.5,-31.618 321.5,-31.618" stroke="#000000" - stroke-width="1.84837" /> - <path + stroke-width="1.84837" /><path id="F_FASN" d="m 1804.19,814.63 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z m -10.69,-8.13 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 74"> - <g - id="text6997-5-1-8-3-7-7-3-7"> - <text + stroke-width="2.23952" /></g><g + id="Group 74"><g + id="text6997-5-1-8-3-7-7-3-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3576,8 +3110,7 @@ id="text2324"><tspan x="1906.49" y="797.15997" - id="tspan2322">CO</tspan></text> - <text + id="tspan2322">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3587,14 +3120,11 @@ id="text2328"><tspan x="1924.5" y="797.15997" - id="tspan2326">₂</tspan></text> - </g> - <path + id="tspan2326">₂</tspan></text></g><path id="R_AcetoacetylACPsynthesis" d="m 1884.51,812.903 c 5.06,-0.402 5.93,-7.502 5.93,-7.502 M 1896.5,852 c 1.5,-35 11.36,-39.231 24,-39.408 m -47.5,0.251 53.28,-0.282 m -18.42,0.208 c 5.03,-0.525 5.3,-7.639 5.3,-7.639" stroke="#000000" - stroke-width="1.9665" /> - <text + stroke-width="1.9665" /><text id="text6997-5-1-8-3-7-7-3-7-7" fill="#000000" xml:space="preserve" @@ -3604,16 +3134,12 @@ letter-spacing="0em"><tspan x="1876.16" y="797.15997" - id="tspan2332">ACP</tspan></text> - <path + id="tspan2332">ACP</tspan></text><path id="F_AcetoacetylACPsynthesis" d="m 1925.33,814.458 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z m -33.93,-8.263 c -1.47,-5.595 -1.47,-5.595 -1.47,-5.595 l -1.11,5.65 1.24,-1.433 z m 23.04,0 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 73"> - <text + stroke-width="2.23952" /></g><g + id="Group 73"><text id="text6997-5-1-8-3-71-2-5-49" fill="#000000" xml:space="preserve" @@ -3624,13 +3150,11 @@ letter-spacing="0em"><tspan x="1777.2" y="865.32098" - id="tspan2337">MalCoA</tspan></text> - <path + id="tspan2337">MalCoA</tspan></text><path id="R_MCAT" d="m 1839.09,860.31 23.43,0.238 m -13,0.003 c 5.06,-0.384 6.22,-8.47 6.22,-8.47 m -10.11,8.511 c -4.92,1.031 -4.5,8.67 -4.5,8.67" stroke="#000000" - stroke-width="1.86971" /> - <text + stroke-width="1.86971" /><text id="text6997-5-1-8-3-7-7-3-7-2" fill="#000000" xml:space="preserve" @@ -3640,8 +3164,7 @@ letter-spacing="0em"><tspan x="1845.02" y="844.15997" - id="tspan2341">CoA</tspan></text> - <text + id="tspan2341">CoA</tspan></text><text id="text7967-8-1" fill="#000000" xml:space="preserve" @@ -3652,8 +3175,7 @@ letter-spacing="0em"><tspan x="1870.99" y="867.72498" - id="tspan2344">MalACP</tspan></text> - <text + id="tspan2344">MalACP</tspan></text><text id="text6997-5-1-8-3-71-2-5-43-4-1" fill="#000000" xml:space="preserve" @@ -3663,16 +3185,12 @@ letter-spacing="0em"><tspan x="1829.86" y="881.15997" - id="tspan2347">ACP</tspan></text> - <path + id="tspan2347">ACP</tspan></text><path id="F_MCAT" d="m 1861.27,862.358 c 5.84,-1.962 5.84,-1.962 5.84,-1.962 l -5.97,-1.524 1.54,1.688 z m -4.4,-9.457 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 79"> - <text + stroke-width="2.23952" /></g><g + id="Group 79"><text id="text7047" fill="#000000" xml:space="preserve" @@ -3682,10 +3200,8 @@ letter-spacing="0em"><tspan x="1645.3199" y="955.15997" - id="tspan2352">AcCoA</tspan></text> - <g - id="text7052"> - <text + id="tspan2352">AcCoA</tspan></text><g + id="text7052"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3698,8 +3214,7 @@ id="tspan2355">H</tspan><tspan x="1617.28" y="955.15997" - id="tspan2357">O</tspan></text> - <text + id="tspan2357">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3709,9 +3224,7 @@ id="text2363"><tspan x="1613.05" y="955.15997" - id="tspan2361">₂</tspan></text> - </g> - <text + id="tspan2361">₂</tspan></text></g><text id="text7078" fill="#000000" xml:space="preserve" @@ -3721,8 +3234,7 @@ letter-spacing="0em"><tspan x="1607.3199" y="920.15997" - id="tspan2366">CoA</tspan></text> - <text + id="tspan2366">CoA</tspan></text><text id="text7164" fill="#000000" xml:space="preserve" @@ -3733,21 +3245,16 @@ letter-spacing="0em"><tspan x="1529.08" y="940.64801" - id="tspan2369">AcAcCoA</tspan></text> - <path + id="tspan2369">AcAcCoA</tspan></text><path id="F_HMGCOAS" d="m 1619.32,928.248 -1.47,-5.596 -1.11,5.65 1.24,-1.433 z m 87.44,8.733 5.84,-1.962 -5.97,-1.524 1.54,1.688 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_HMGCOAS" d="m 1607,935.475 h 100.5 m -93.23,8.722 c 0,0 -2.66,-7.719 2.23,-8.722 5.05,-0.886 1.34,-7.755 1.34,-7.755 m 49.1,7.755 c -4.89,1.003 -4.47,8.43 -4.47,8.43" stroke="#000000" - stroke-width="1.77188" /> - </g> - <g - id="Group 72"> - <text + stroke-width="1.77188" /></g><g + id="Group 72"><text id="PalmCoA" fill="#000000" xml:space="preserve" @@ -3758,8 +3265,7 @@ letter-spacing="0em"><tspan x="2195.4099" y="739.547" - id="tspan2375">PalmCoA</tspan></text> - <text + id="tspan2375">PalmCoA</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-1-2" fill="#000000" xml:space="preserve" @@ -3769,8 +3275,7 @@ letter-spacing="0em"><tspan x="2242.3201" y="802.15997" - id="tspan2378">CoA</tspan></text> - <text + id="tspan2378">CoA</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-8-7" fill="#000000" xml:space="preserve" @@ -3780,8 +3285,7 @@ letter-spacing="0em"><tspan x="2247.5" y="761.15997" - id="tspan2381">AMP</tspan></text> - <text + id="tspan2381">AMP</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-2-5" transform="rotate(0.250513,-173384.82,514314.31)" fill="#000000" @@ -3792,8 +3296,7 @@ letter-spacing="0em"><tspan x="0" y="11.1602" - id="tspan2384">PPi</tspan></text> - <text + id="tspan2384">PPi</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-1-2-4" fill="#000000" xml:space="preserve" @@ -3803,18 +3306,15 @@ letter-spacing="0em"><tspan x="2242.27" y="788.15997" - id="tspan2387">ATP</tspan></text> - <path + id="tspan2387">ATP</tspan></text><path id="F_palmitateActivation" d="m 2238.71,758.266 c 5.73,-0.74 5.73,-0.74 5.73,-0.74 l -5.46,-1.827 1.26,1.419 z m 0.79,13.234 c 1.79,-0.5 3.5,-1.5 3.5,-1.5 l -4.29,-1.764 1.29,1.764 z m -6.33,-19.396 C 2231.34,747 2231.34,747 2231.34,747 l -1.34,5.247 1.52,-1.365 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_palmitateActivation" d="m 2239.79,757.019 c -5.7,-1.617 -8.64,3.967 -8.64,3.967 m 9.02,21.514 c 0,0 -8.71,0.811 -8.71,-5 0,0 0,-7.5 8.71,-7.5 m -8.71,25 c 1.17,4.019 8.71,2.811 8.71,2.811 m -8.71,5.189 v -52.878" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-5-1" fill="#000000" xml:space="preserve" @@ -3825,11 +3325,8 @@ letter-spacing="0em"><tspan x="2210.3701" y="817.547" - id="tspan2392">Palm</tspan></text> - </g> - <g - id="Group 76"> - <text + id="tspan2392">Palm</tspan></text></g><g + id="Group 76"><text id="text7967-8" fill="#000000" xml:space="preserve" @@ -3840,8 +3337,7 @@ letter-spacing="0em"><tspan x="1936.13" y="817.547" - id="tspan2396">AcAcACP</tspan></text> - <text + id="tspan2396">AcAcACP</tspan></text><text id="text6997-5-1-8-3-7-4-7" fill="#000000" xml:space="preserve" @@ -3851,10 +3347,8 @@ letter-spacing="0em"><tspan x="2096.1399" y="833.15997" - id="tspan2399">14 NADPH</tspan></text> - <g - id="text6997-5-1-8-3-7-7-9-3"> - <text + id="tspan2399">14 NADPH</tspan></text><g + id="text6997-5-1-8-3-7-7-9-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3864,8 +3358,7 @@ id="text2404"><tspan x="2022.37" y="794.15997" - id="tspan2402">14 NADP</tspan></text> - <text + id="tspan2402">14 NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3875,11 +3368,8 @@ id="text2408"><tspan x="2072.4199" y="794.15997" - id="tspan2406">⁺</tspan></text> - </g> - <g - id="text6997-5-1-8-3-71-5-6-17"> - <text + id="tspan2406">⁺</tspan></text></g><g + id="text6997-5-1-8-3-71-5-6-17"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3892,8 +3382,7 @@ id="tspan2411">6 H</tspan><tspan x="2201.29" y="794.15997" - id="tspan2413">O</tspan></text> - <text + id="tspan2413">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3903,11 +3392,8 @@ id="text2419"><tspan x="2197.0601" y="794.15997" - id="tspan2417">₂</tspan></text> - </g> - <g - id="text6997-5-1-8-3-71-5-7-3-5-8"> - <text + id="tspan2417">₂</tspan></text></g><g + id="text6997-5-1-8-3-71-5-7-3-5-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3917,8 +3403,7 @@ id="text2424"><tspan x="2134.48" y="794.15997" - id="tspan2422">6 CO</tspan></text> - <text + id="tspan2422">6 CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3928,9 +3413,7 @@ id="text2428"><tspan x="2162.51" y="794.15997" - id="tspan2426">₂</tspan></text> - </g> - <text + id="tspan2426">₂</tspan></text></g><text id="text7967-5-3" fill="#000000" xml:space="preserve" @@ -3940,8 +3423,7 @@ letter-spacing="0em"><tspan x="2033.48" y="833.15997" - id="tspan2431">6 MalACP</tspan></text> - <text + id="tspan2431">6 MalACP</tspan></text><text id="text6997-5-1-8-3-71-5-6-1-4" fill="#000000" xml:space="preserve" @@ -3951,15 +3433,12 @@ letter-spacing="0em"><tspan x="2088.48" y="794.15997" - id="tspan2434">7 ACP</tspan></text> - <path + id="tspan2434">7 ACP</tspan></text><path id="F_FA160ACPH" d="M 2194.58,804.595 C 2193.12,799 2193.12,799 2193.12,799 l -1.12,5.65 1.25,-1.433 z m -43.12,-0.5 C 2150,798.5 2150,798.5 2150,798.5 l -1.12,5.649 1.25,-1.432 z m -43.96,-0.878 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z m -52.5,0 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z m 145.46,10.961 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="text3083"> - <text + stroke-width="2.23952" /><g + id="text3083"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3969,8 +3448,7 @@ id="text2440"><tspan x="2171.21" y="833.15997" - id="tspan2438">14 H</tspan></text> - <text + id="tspan2438">14 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -3980,17 +3458,12 @@ id="text2444"><tspan x="2196.5801" y="833.15997" - id="tspan2442">⁺</tspan></text> - </g> - <path + id="tspan2442">⁺</tspan></text></g><path id="R_FA160ACPH" d="m 2184,821.778 c 0,0 0.2,-8.126 5.05,-9.197 4.84,-0.867 3.61,-8.201 3.61,-8.201 m -177.16,8.073 c 0,0 37.79,0 62,0 m 123.44,0 c 0,0 -43.54,0 -71.44,0 m -27.5,0 c 4.8,-0.954 4.08,-9.019 4.08,-9.019 m -56.08,9.019 c 4.8,-0.954 3.58,-9.019 3.58,-9.019 m 92.66,8.832 c 4.84,-0.868 3.61,-8.201 3.61,-8.201 m -72.35,8.388 c -11.5,-0.187 -11.5,9.325 -11.5,9.325 m 11.5,-9.325 c 20.31,0 31.69,0 52,0 m 0,0 c -8.5,-0.187 -8.5,9.325 -8.5,9.325" stroke="#000000" - stroke-width="2.08132" /> - </g> - <g - id="Group 78"> - <text + stroke-width="2.08132" /></g><g + id="Group 78"><text id="text7122" fill="#000000" xml:space="preserve" @@ -4001,8 +3474,7 @@ letter-spacing="0em"><tspan x="1718.38" y="939.547" - id="tspan2449">HMGCoA</tspan></text> - <text + id="tspan2449">HMGCoA</tspan></text><text id="text7188" fill="#000000" xml:space="preserve" @@ -4012,8 +3484,7 @@ letter-spacing="0em"><tspan x="1883.1" y="954.15997" - id="tspan2452">3 ATP</tspan></text> - <text + id="tspan2452">3 ATP</tspan></text><text id="text7192" fill="#000000" xml:space="preserve" @@ -4023,8 +3494,7 @@ letter-spacing="0em"><tspan x="1792.3199" y="919.15997" - id="tspan2455">CoA</tspan></text> - <text + id="tspan2455">CoA</tspan></text><text id="text7214" fill="#000000" xml:space="preserve" @@ -4034,10 +3504,8 @@ letter-spacing="0em"><tspan x="1772.48" y="954.15997" - id="tspan2458">2 NADPH</tspan></text> - <g - id="text7222"> - <text + id="tspan2458">2 NADPH</tspan></text><g + id="text7222"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4047,8 +3515,7 @@ id="text2463"><tspan x="1823.21" y="919.15997" - id="tspan2461">2 NADP</tspan></text> - <text + id="tspan2461">2 NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4058,9 +3525,7 @@ id="text2467"><tspan x="1866.58" y="919.15997" - id="tspan2465">⁺</tspan></text> - </g> - <text + id="tspan2465">⁺</tspan></text></g><text id="text7230" fill="#000000" xml:space="preserve" @@ -4070,10 +3535,8 @@ letter-spacing="0em"><tspan x="1902.48" y="919.15997" - id="tspan2470">3 ADP</tspan></text> - <g - id="text7238"> - <text + id="tspan2470">3 ADP</tspan></text><g + id="text7238"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4083,8 +3546,7 @@ id="text2475"><tspan x="1940.49" y="919.15997" - id="tspan2473">CO</tspan></text> - <text + id="tspan2473">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4094,9 +3556,7 @@ id="text2479"><tspan x="1958.5" y="919.15997" - id="tspan2477">₂</tspan></text> - </g> - <text + id="tspan2477">₂</tspan></text></g><text id="text7246" fill="#000000" xml:space="preserve" @@ -4106,21 +3566,16 @@ letter-spacing="0em"><tspan x="1881.16" y="919.15997" - id="tspan2482">Pi</tspan></text> - <path + id="tspan2482">Pi</tspan></text><path id="F_DPMVD" d="m 1946.9,927.988 c -1.47,-5.596 -1.47,-5.596 -1.47,-5.596 l -1.11,5.65 1.24,-1.433 z m -23.44,-0.001 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z m -35.96,0 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.65 1.25,-1.433 z m -83,0.055 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 41.33,-0.054 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 104.44,9.104 c 5.83,-1.962 5.83,-1.962 5.83,-1.962 l -5.96,-1.524 1.54,1.688 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_DPMVD" d="m 1792,935.602 160,-0.176 m -96.86,0.205 c -7.95,0.876 -7.27,7.369 -7.27,7.369 m 58.88,-7.444 c -7.95,0.876 -7.27,7.369 -7.27,7.369 m -102.4,-7.434 c 8.33,-0.779 6.21,-7.369 6.21,-7.369 m 2.08,7.509 c -7.94,0.876 -7.26,7.369 -7.26,7.369 m 40.34,-7.618 c 7.87,-0.782 5.87,-7.382 5.87,-7.382 m 35.82,7.382 c 7.87,-0.782 5.87,-7.382 5.87,-7.382 m 30.31,7.382 c 7.86,-0.782 5.86,-7.382 5.86,-7.382 m 17.54,7.382 c 7.87,-0.782 5.87,-7.382 5.87,-7.382" stroke="#000000" - stroke-width="2.13327" /> - </g> - <g - id="Group 77"> - <text + stroke-width="2.13327" /></g><g + id="Group 77"><text id="text6997-5-1-8-3-7-7-3" fill="#000000" xml:space="preserve" @@ -4130,8 +3585,7 @@ letter-spacing="0em"><tspan x="2007.15" y="919.15997" - id="tspan2488">2 PPi</tspan></text> - <text + id="tspan2488">2 PPi</tspan></text><text id="text7967" fill="#000000" xml:space="preserve" @@ -4142,8 +3596,7 @@ letter-spacing="0em"><tspan x="2044.16" y="941.547" - id="tspan2491">fPP</tspan></text> - <text + id="tspan2491">fPP</tspan></text><text id="text6997-5-1-8-3-71-2-5-43" fill="#000000" xml:space="preserve" @@ -4153,8 +3606,7 @@ letter-spacing="0em"><tspan x="1995.47" y="955.15997" - id="tspan2494">2 ippPP</tspan></text> - <text + id="tspan2494">2 ippPP</tspan></text><text id="text7208" fill="#000000" xml:space="preserve" @@ -4165,21 +3617,16 @@ letter-spacing="0em"><tspan x="1959.3199" y="941.547" - id="tspan2497">ippPP</tspan></text> - <path + id="tspan2497">ippPP</tspan></text><path id="R_DMATT" d="m 2006.5,935.135 h 28.82 m -15.61,0.486 c -4.93,1.002 -4.33,8.145 -4.33,8.145 m 3.24,-8.618 c 4.94,-0.758 3.5,-6.89 3.5,-6.89" stroke="#000000" - stroke-width="1.73438" /> - <path + stroke-width="1.73438" /><path id="F_DMATT" d="m 2033.85,936.926 c 5.83,-1.963 5.83,-1.963 5.83,-1.963 l -5.96,-1.523 1.54,1.688 z m -10.54,-8.025 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - </g> - <g - id="Group 82"> - <text + stroke-width="2.23952" /></g><g + id="Group 82"><text id="text6997-5-1-8-3-7-4" fill="#000000" xml:space="preserve" @@ -4189,10 +3636,8 @@ letter-spacing="0em"><tspan x="2188.1399" y="957.15997" - id="tspan2503">13 NADPH</tspan></text> - <g - id="text6997-5-1-8-3-71-2-7"> - <text + id="tspan2503">13 NADPH</tspan></text><g + id="text6997-5-1-8-3-71-2-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4202,8 +3647,7 @@ id="text2508"><tspan x="2171.1799" y="957.15997" - id="tspan2506">2</tspan></text> - <text + id="tspan2506">2</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4213,11 +3657,8 @@ id="text2512"><tspan x="2145.1399" y="957.15997" - id="tspan2510">10 O</tspan></text> - </g> - <g - id="text6997-5-1-8-3-7-7-9"> - <text + id="tspan2510">10 O</tspan></text></g><g + id="text6997-5-1-8-3-7-7-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4227,8 +3668,7 @@ id="text2517"><tspan x="2267.3701" y="917.15997" - id="tspan2515">13 NADP</tspan></text> - <text + id="tspan2515">13 NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4238,9 +3678,7 @@ id="text2521"><tspan x="2317.4199" y="917.15997" - id="tspan2519">⁺</tspan></text> - </g> - <text + id="tspan2519">⁺</tspan></text></g><text id="text6997-5-1-8-3-71-5-6" fill="#000000" xml:space="preserve" @@ -4250,8 +3688,7 @@ letter-spacing="0em"><tspan x="2077.1499" y="917.15997" - id="tspan2524">2 PPi</tspan></text> - <text + id="tspan2524">2 PPi</tspan></text><text id="text6997-5-1-8-3-71-5-7-36" fill="#000000" xml:space="preserve" @@ -4261,10 +3698,8 @@ letter-spacing="0em"><tspan x="2118.1399" y="917.15997" - id="tspan2527">formate</tspan></text> - <g - id="text6997-5-1-8-3-71-5-7-3-5"> - <text + id="tspan2527">formate</tspan></text><g + id="text6997-5-1-8-3-71-5-7-3-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4274,8 +3709,7 @@ id="text2532"><tspan x="2171.48" y="917.15997" - id="tspan2530">2 CO</tspan></text> - <text + id="tspan2530">2 CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4285,9 +3719,7 @@ id="text2536"><tspan x="2199.51" y="917.15997" - id="tspan2534">₂</tspan></text> - </g> - <text + id="tspan2534">₂</tspan></text></g><text id="text7967-0" fill="#000000" xml:space="preserve" @@ -4298,8 +3730,7 @@ letter-spacing="0em"><tspan x="2306.21" y="940.547" - id="tspan2539">Chol</tspan></text> - <text + id="tspan2539">Chol</tspan></text><text id="text7967-5" fill="#000000" xml:space="preserve" @@ -4309,10 +3740,8 @@ letter-spacing="0em"><tspan x="2255.3301" y="957.15997" - id="tspan2542">fPP</tspan></text> - <g - id="text6997-5-1-8-3-71-5-6-1"> - <text + id="tspan2542">fPP</tspan></text><g + id="text6997-5-1-8-3-71-5-6-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4325,8 +3754,7 @@ id="tspan2545">15 H</tspan><tspan x="2245.6299" y="917.15997" - id="tspan2547">O</tspan></text> - <text + id="tspan2547">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4336,21 +3764,16 @@ id="text2554"><tspan x="2241.3999" y="917.15997" - id="tspan2551">₂</tspan></text> - </g> - <path + id="tspan2551">₂</tspan></text></g><path id="F_DSMSTOLR" d="m 2296.59,937.274 c 5.84,-1.962 5.84,-1.962 5.84,-1.962 l -5.97,-1.524 1.54,1.689 z m -199.01,-11.328 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 L 2095,926 l 1.25,-1.433 z m 46.25,0.528 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 46.13,0 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 48.87,0 c -1.46,-5.596 -1.46,-5.596 -1.46,-5.596 l -1.12,5.65 1.25,-1.433 z m 50.67,0.026 c -1.46,-5.595 -1.46,-5.595 -1.46,-5.595 l -1.12,5.649 1.25,-1.433 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_DSMSTOLR" d="m 2132.5,935.635 c 11,-0.017 10,-9.468 10,-9.468 m -55.5,9.327 c 9.5,0 9.5,-9.328 9.5,-9.328 m 186.35,9.428 c 7.4,-0.998 5.52,-9.427 5.52,-9.427 m -20,9.327 c -7.48,1.119 -6.84,9.411 -6.84,9.411 m -31.03,-9.338 c 7.4,-0.998 7,-9.4 7,-9.4 m -60.3,9.4 c 11.3,-0.018 11.3,-9.4 11.3,-9.4 m -21.8,9.327 c -7.48,1.119 -6.84,9.411 -6.84,9.411 m -35.72,-9.316 c -7.47,1.119 -6.83,9.411 -6.83,9.411 m -43.81,-9.506 h 151.27 m 74.23,0.015 -74.23,-0.015 m 0,0 c -6.84,0 -6.84,9.411 -6.84,9.411" stroke="#000000" - stroke-width="2.08645" /> - <g - id="text3145"> - <text + stroke-width="2.08645" /><g + id="text3145"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4360,8 +3783,7 @@ id="text2561"><tspan x="2103.21" y="957.15997" - id="tspan2559">16 H</tspan></text> - <text + id="tspan2559">16 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -4371,10 +3793,7 @@ id="text2565"><tspan x="2128.5801" y="957.15997" - id="tspan2563">⁺</tspan></text> - </g> - </g> - <text + id="tspan2563">⁺</tspan></text></g></g><text id="text6997-5-1-8" fill="#000000" xml:space="preserve" @@ -4385,10 +3804,8 @@ letter-spacing="0em"><tspan x="1429" y="854.203" - id="tspan2569">AcCoA</tspan></text> - <g - id="Group 80"> - <text + id="tspan2569">AcCoA</tspan></text><g + id="Group 80"><text id="text7122_2" fill="#000000" xml:space="preserve" @@ -4399,29 +3816,23 @@ letter-spacing="0em"><tspan x="1716.38" y="1068.55" - id="tspan2572">HMGCoA</tspan></text> - <path + id="tspan2572">HMGCoA</tspan></text><path id="F_HMGCOAtm" d="M 1746.49,951.86 C 1744.6,946 1744.6,946 1744.6,946 l -1.6,5.942 1.71,-1.516 z" stroke="#000000" - stroke-width="2.66667" /> - <path + stroke-width="2.66667" /><path id="R_HMGCOAtm" d="M 1745,1047 V 951" stroke="#000000" - stroke-width="1.40903" /> - <path + stroke-width="1.40903" /><path id="B_HMGCOAtm" d="m 1743,1047.15 c 2.45,3.85 2.45,3.85 2.45,3.85 l 1.55,-4 -1.89,1.06 z" stroke="#000000" - stroke-width="2.66667" /> - </g> - <g + stroke-width="2.66667" /></g><g id="Group 80-3" transform="translate(-286.84663,-79.989336)" inkscape:transform-center-x="-114.47137" - inkscape:transform-center-y="-3.5938632"> - <text + inkscape:transform-center-y="-3.5938632"><text id="text7122_2-6" fill="#000000" xml:space="preserve" @@ -4438,8 +3849,7 @@ y="1054.1113"><tspan x="1721.1489" y="1054.1113" - id="tspan2572-7">aCarn</tspan></tspan></text> - <text + id="tspan2572-7">aCarn</tspan></tspan></text><text id="text7122_2-6-2" fill="#000000" xml:space="preserve" @@ -4456,29 +3866,22 @@ y="1146.1766"><tspan x="1722.4319" y="1146.1766" - id="tspan2572-7-0">aCarn</tspan></tspan></text> - <path + id="tspan2572-7-0">aCarn</tspan></tspan></text><path style="opacity:0;fill:#1a1a1a;fill-opacity:0.891118;stroke:#e60000;stroke-width:0.999862" d="m 1784.874,1123.0143 14.9467,12.9971 21.8875,-0.1614 10.0512,-16.4468" - 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id="tspan2733">GDP</tspan></text> - <path + id="tspan2733">GDP</tspan></text><path id="F_r0801" fill-rule="evenodd" clip-rule="evenodd" d="m 1830.2,1948.63 c -8.79,3.97 -8.79,3.97 -8.79,3.97 l 9.47,1.84 -2.62,-2.64 z m 77.01,-13.86 c -3.17,-7.54 -3.17,-7.54 -3.17,-7.54 l -2.64,7.77 2.84,-2.03 z" stroke="#000000" - stroke-width="2.37958" /> - <path + stroke-width="2.37958" /><path id="F_H2Otm" fill-rule="evenodd" clip-rule="evenodd" d="m 1842.74,2052.54 c -9.22,2.83 -9.22,2.83 -9.22,2.83 l 9.15,3.02 -2.26,-2.95 z" stroke="#000000" - stroke-width="2.61244" /> - <path + stroke-width="2.61244" /><path id="R_H2Otm" d="m 1836.17,2055.67 h 67.25" stroke="#000000" - stroke-width="1.89358" /> - <g - id="text6979-5-4-1-7-9-30-5-8"> - <text + stroke-width="1.89358" /><g + id="text6979-5-4-1-7-9-30-5-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6259,8 +5418,7 @@ id="tspan2739">H</tspan><tspan x="1929.37" y="2060.55" - id="tspan2741">O</tspan></text> - <text + id="tspan2741">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6271,11 +5429,8 @@ id="text2747"><tspan x="1923.74" y="2060.55" - id="tspan2745">₂</tspan></text> - </g> - <g - id="text6979-5-4-1-7-9-30-93-0"> - <text + id="tspan2745">₂</tspan></text></g><g + id="text6979-5-4-1-7-9-30-93-0"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6289,8 +5444,7 @@ id="tspan2750">H</tspan><tspan x="1814.37" y="2060.55" - id="tspan2752">O</tspan></text> - <text + id="tspan2752">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6301,14 +5455,10 @@ id="text2758"><tspan x="1808.74" y="2060.55" - id="tspan2756">₂</tspan></text> - </g> - <g - id="Group 42"> - <g + id="tspan2756">₂</tspan></text></g><g + id="Group 42"><g id="text6979-5-4-1-7-9-30-5-8-5" - transform="translate(1.7572453,727.15309)"> - <text + transform="translate(1.7572453,727.15309)"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6319,8 +5469,7 @@ id="text2763"><tspan x="771.10199" y="1272.55" - id="tspan2761">O</tspan></text> - <text + id="tspan2761">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6331,12 +5480,9 @@ id="text2767"><tspan x="783.55499" y="1272.55" - id="tspan2765">₂</tspan></text> - </g> - <g + id="tspan2765">₂</tspan></text></g><g id="text6979-5-4-1-7-9-30-93-0-9" - transform="translate(1.7572453,727.15309)"> - <text + transform="translate(1.7572453,727.15309)"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6347,8 +5493,7 @@ id="text2772"><tspan x="662.10199" y="1272.55" - id="tspan2770">O</tspan></text> - <text + id="tspan2770">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6359,22 +5504,17 @@ id="text2776"><tspan x="674.55499" y="1272.55" - id="tspan2774">₂</tspan></text> - </g> - <path + id="tspan2774">₂</tspan></text></g><path id="F_O2tm" fill-rule="evenodd" clip-rule="evenodd" d="m 756.96325,1997.0531 c 9.221,-2.82 9.221,-2.82 9.221,-2.82 l -9.155,-3.03 2.264,2.95 z" stroke="#000000" - stroke-width="2.61244" /> - <path + stroke-width="2.61244" /><path id="R_O2tm" d="m 686.49325,1994.7131 h 75.546" stroke="#000000" - stroke-width="2.00699" /> - </g> - <text + stroke-width="2.00699" /></g><text id="text6979-5-4" fill="#000000" xml:space="preserve" @@ -6384,10 +5524,8 @@ letter-spacing="0em"><tspan x="738.48999" y="2131.21" - id="tspan2782">NADH</tspan></text> - <g - id="text7051-9-3"> - <text + id="tspan2782">NADH</tspan></text><g + id="text7051-9-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6397,8 +5535,7 @@ id="text2787"><tspan x="986.224" y="2131.1599" - id="tspan2785">NAD</tspan></text> - <text + id="tspan2785">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6408,11 +5545,8 @@ id="text2791"><tspan x="1011.57" y="2131.1599" - id="tspan2789">⁺</tspan></text> - </g> - <g - id="text7009-5-6"> - <text + id="tspan2789">⁺</tspan></text></g><g + id="text7009-5-6"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6422,8 +5556,7 @@ id="text2796"><tspan x="1038.13" y="2131.1599" - id="tspan2794">0.95 QH</tspan></text> - <text + id="tspan2794">0.95 QH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6433,11 +5566,8 @@ id="text2800"><tspan x="1082.86" y="2131.1599" - id="tspan2798">₂</tspan></text> - </g> - <g - id="text6985-0-7"> - <text + id="tspan2798">₂</tspan></text></g><g + id="text6985-0-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6447,8 +5577,7 @@ id="text2805"><tspan x="862.20203" y="2131.1599" - id="tspan2803">4.75 H</tspan></text> - <text + id="tspan2803">4.75 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6458,9 +5587,7 @@ id="text2809"><tspan x="897.59302" y="2131.1599" - id="tspan2807">⁺</tspan></text> - </g> - <text + id="tspan2807">⁺</tspan></text></g><text id="text6312-9" fill="#000000" xml:space="preserve" @@ -6470,10 +5597,8 @@ letter-spacing="0em"><tspan x="927.47101" y="2131.1599" - id="tspan2812">0.95 Q</tspan></text> - <g - id="text6985-0-7-1"> - <text + id="tspan2812">0.95 Q</tspan></text><g + id="text6985-0-7-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6483,8 +5608,7 @@ id="text2817"><tspan x="931.04199" y="2217.1599" - id="tspan2815">3.8 H</tspan></text> - <text + id="tspan2815">3.8 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6494,11 +5618,8 @@ id="text2821"><tspan x="959.75299" y="2217.1599" - id="tspan2819">⁺</tspan></text> - </g> - <g - id="text6979-5-4-0"> - <text + id="tspan2819">⁺</tspan></text></g><g + id="text6979-5-4-0"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6508,8 +5629,7 @@ id="text2826"><tspan x="1022.49" y="2080.1599" - id="tspan2824">FADH</tspan></text> - <text + id="tspan2824">FADH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6519,9 +5639,7 @@ id="text2830"><tspan x="1054.5" y="2080.1599" - id="tspan2828">₂</tspan></text> - </g> - <text + id="tspan2828">₂</tspan></text></g><text id="text7051-9-3-8" fill="#000000" xml:space="preserve" @@ -6531,10 +5649,8 @@ letter-spacing="0em"><tspan x="1089.33" y="2080.1599" - id="tspan2833">FAD</tspan></text> - <g - id="text7009-5-6-6"> - <text + id="tspan2833">FAD</tspan></text><g + id="text7009-5-6-6"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6544,8 +5660,7 @@ id="text2838"><tspan x="1130.49" y="2080.1599" - id="tspan2836">QH</tspan></text> - <text + id="tspan2836">QH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6555,9 +5670,7 @@ id="text2842"><tspan x="1148.5" y="2080.1599" - id="tspan2840">₂</tspan></text> - </g> - <text + id="tspan2840">₂</tspan></text></g><text id="text6312-9-6" fill="#000000" xml:space="preserve" @@ -6567,13 +5680,11 @@ letter-spacing="0em"><tspan x="1068.33" y="2080.1599" - id="tspan2845">Q</tspan></text> - <path + id="tspan2845">Q</tspan></text><path id="R_FADH2ETC" d="m 1042.46,2086.72 v 21.18 h 99.93 v -21.18 m -69.37,0.23 v 20.1 m 28.66,0 v -19.47" stroke="#000000" - stroke-width="1.23699" /> - <text + stroke-width="1.23699" /><text id="text6979-5-4-1" fill="#000000" xml:space="preserve" @@ -6583,8 +5694,7 @@ letter-spacing="0em"><tspan x="1174.15" y="2131.1599" - id="tspan2849">2 Cytc-ox</tspan></text> - <text + id="tspan2849">2 Cytc-ox</tspan></text><text id="text7051-9-3-6" fill="#000000" xml:space="preserve" @@ -6594,8 +5704,7 @@ letter-spacing="0em"><tspan x="1323.3101" y="2131.1599" - id="tspan2852">2 Cytc-red</tspan></text> - <text + id="tspan2852">2 Cytc-red</tspan></text><text id="text7009-5-6-63" fill="#000000" xml:space="preserve" @@ -6605,10 +5714,8 @@ letter-spacing="0em"><tspan x="1395.33" y="2131.1599" - id="tspan2855">Q</tspan></text> - <g - id="text6985-0-7-7"> - <text + id="tspan2855">Q</tspan></text><g + id="text6985-0-7-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6618,8 +5725,7 @@ id="text2860"><tspan x="1238.05" y="2131.1599" - id="tspan2858">2 H</tspan></text> - <text + id="tspan2858">2 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6629,11 +5735,8 @@ id="text2864"><tspan x="1256.74" y="2131.1599" - id="tspan2862">⁺</tspan></text> - </g> - <g - id="text6312-9-5"> - <text + id="tspan2862">⁺</tspan></text></g><g + id="text6312-9-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6643,8 +5746,7 @@ id="text2869"><tspan x="1274.49" y="2131.1599" - id="tspan2867">QH</tspan></text> - 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stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text7967-0-3-9-1-2-4" fill="#000000" xml:space="preserve" @@ -6840,8 +5915,7 @@ letter-spacing="0em"><tspan x="1896.4399" y="1988.55" - id="tspan2932">Pi</tspan></text> - <text + id="tspan2932">Pi</tspan></text><text id="text7967-0-3-9-1-2-1" fill="#000000" xml:space="preserve" @@ -6852,20 +5926,16 @@ letter-spacing="0em"><tspan x="1845.4399" y="1988.55" - id="tspan2935">Pi</tspan></text> - <g - id="Group 46"> - <path + id="tspan2935">Pi</tspan></text><g + id="Group 46"><path id="R_GLYtm" d="m 752.209,1936.85 -64.786,-0.29" stroke="#000000" - stroke-width="2.65716" /> - <path + stroke-width="2.65716" /><path id="F_GLYtm" d="m 751.762,1939.44 c 9.665,-3.1 9.665,-3.1 9.665,-3.1 l -9.798,-2.65 2.499,2.82 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text7967-0-3-0-0-89" fill="#000000" xml:space="preserve" @@ -6876,8 +5946,7 @@ letter-spacing="0em"><tspan x="658.09399" y="1939.55" - id="tspan2940">Gly</tspan></text> - <text + id="tspan2940">Gly</tspan></text><text id="text7967-0-3-0-2-8-6" fill="#000000" xml:space="preserve" @@ -6888,9 +5957,7 @@ letter-spacing="0em"><tspan x="766.09399" y="1940.55" - id="tspan2943">Gly</tspan></text> - </g> - <text + id="tspan2943">Gly</tspan></text></g><text id="text7967-0-3-0-2-6-3-7" fill="#000000" xml:space="preserve" @@ -6901,8 +5968,7 @@ letter-spacing="0em"><tspan x="783.15601" y="1548.85" - id="tspan2947">Mal</tspan></text> - <text + id="tspan2947">Mal</tspan></text><text id="text7967-0-3-9-1-2-1-3-4-0" fill="#000000" xml:space="preserve" @@ -6913,8 +5979,7 @@ letter-spacing="0em"><tspan x="680.15002" y="1513.55" - id="tspan2950">AKG</tspan></text> - <text + id="tspan2950">AKG</tspan></text><text id="text7967-0-3-9-1-2-1-3-4-8-7" fill="#000000" xml:space="preserve" @@ -6925,23 +5990,19 @@ letter-spacing="0em"><tspan x="734.31201" y="1513.91" - id="tspan2953">AKG</tspan></text> - <path + id="tspan2953">AKG</tspan></text><path id="R_AKGMALtm" d="m 745.745,1543.38 c 7.197,-1.54 5.369,-14.54 5.369,-14.54 m -43.653,0.3 c -5.127,3.9 4.567,14.88 4.567,14.88 m 53.51,-0.92 -82.33,-0.33" stroke="#000000" - stroke-width="2.11767" /> - <path + stroke-width="2.11767" /><path id="F_AKGMALtm" d="m 753.439,1530.28 c -0.986,-3.24 -1.972,-6.47 -2.958,-9.71 -0.932,3.25 -1.863,6.51 -2.794,9.76 1.642,-1.71 3.285,-3.26 4.963,-0.71 0.263,0.22 0.526,0.44 0.789,0.66 z m -69.505,9.83 c -3.229,1.01 -6.458,2.02 -9.687,3.03 3.26,0.9 6.52,1.81 9.779,2.72 -1.718,-1.63 -3.282,-3.26 -0.742,-4.96 0.217,-0.26 0.433,-0.53 0.65,-0.79 z" stroke="#000000" - stroke-width="2.66667" /> - <path + stroke-width="2.66667" /><path id="R_ATPS4mi" d="m 1810.34,2159.61 -0.02,-18.89 m -93.65,19.15 -0.3,43.6 m 51.22,-44.06 -0.03,-18.51 m -34.03,-3.31 v 21.85 m -33.03,-22.36 -0.03,22.56 150.92,0.49 0.04,-22.55" stroke="#000000" - stroke-width="1.26667" /> - <text + stroke-width="1.26667" /><text id="text7009-5-6-63-1-9" fill="#000000" xml:space="preserve" @@ -6951,8 +6012,7 @@ letter-spacing="0em"><tspan x="1689.16" y="2131.1599" - id="tspan2959">ADP</tspan></text> - <text + id="tspan2959">ADP</tspan></text><text id="text7009-5-6-63-1-5" fill="#000000" xml:space="preserve" @@ -6962,8 +6022,7 @@ letter-spacing="0em"><tspan x="1728.16" y="2131.1599" - id="tspan2962">Pi</tspan></text> - <text + id="tspan2962">Pi</tspan></text><text id="text7009-5-6-63-1-9-0" fill="#000000" xml:space="preserve" @@ -6973,10 +6032,8 @@ letter-spacing="0em"><tspan x="1756.27" y="2131.1599" - id="tspan2965">ATP</tspan></text> - <g - id="text7051-9-3-6-2-1"> - <text + id="tspan2965">ATP</tspan></text><g + id="text7051-9-3-6-2-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -6989,8 +6046,7 @@ id="tspan2968">H</tspan><tspan x="1810.28" y="2131.1599" - id="tspan2970">O</tspan></text> - <text + id="tspan2970">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7000,11 +6056,8 @@ id="text2976"><tspan x="1806.05" y="2131.1599" - id="tspan2974">₂</tspan></text> - </g> - <g - id="text7051-9-3-6-2-6"> - <text + id="tspan2974">₂</tspan></text></g><g + id="text7051-9-3-6-2-6"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7014,8 +6067,7 @@ id="text2981"><tspan x="1840.05" y="2131.1599" - id="tspan2979">4 H</tspan></text> - <text + id="tspan2979">4 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7025,9 +6077,7 @@ id="text2985"><tspan x="1858.74" y="2131.1599" - id="tspan2983">⁺</tspan></text> - </g> - <text + id="tspan2983">⁺</tspan></text></g><text id="text7967-0-3-6-2-7-4-34-0-5-2-1-4-5" transform="translate(1183.09,1923.51)" fill="#000000" @@ -7039,8 +6089,7 @@ letter-spacing="0em"><tspan x="0" y="14.5469" - id="tspan2988">10-formylTHF</tspan></text> - <text + id="tspan2988">10-formylTHF</tspan></text><text id="text7967-0-3-6-2-7-4-34-0-5-2-1-4-2-9" fill="#000000" xml:space="preserve" @@ -7051,10 +6100,8 @@ letter-spacing="0em"><tspan x="1039.04" y="1937.71" - id="tspan2991">5,10mTHF</tspan></text> - <g - id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-5-5-1"> - <text + id="tspan2991">5,10mTHF</tspan></text><g + id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-5-5-1"><text transform="rotate(0.0309296,-3633961.1,2079729.9)" fill="#000000" xml:space="preserve" @@ -7068,8 +6115,7 @@ id="tspan2994">H</tspan><tspan x="13.2779" y="11.1602" - id="tspan2996">O</tspan></text> - <text + id="tspan2996">O</tspan></text><text transform="rotate(0.0309296,-3633961.1,2079729.9)" fill="#000000" xml:space="preserve" @@ -7080,9 +6126,7 @@ id="text3003"><tspan x="9.0541096" y="11.1602" - id="tspan3001">₂</tspan></text> - </g> - <text + id="tspan3001">₂</tspan></text></g><text id="text7967-0-3-6-2-7-4-34-0-5-2-7-4" transform="translate(873.06,1923.29)" fill="#000000" @@ -7094,23 +6138,19 @@ letter-spacing="0em"><tspan x="0" y="14.5469" - id="tspan3006">5,10meTHF</tspan></text> - <path + id="tspan3006">5,10meTHF</tspan></text><path id="R_MTHFDm" d="M 1026.5,1933.32 H 970.072 M 1017,1951 c 3.47,-12.99 -8,-17.68 -8,-17.68 m -23.297,0.87 c -7.014,2.08 -9.203,14.31 -9.203,14.31" stroke="#000000" - stroke-width="2.45082" /> - <path + stroke-width="2.45082" /><path id="F_MTHFDm" d="m 972.46,1930.36 c -8.43,2.99 -8.43,2.99 -8.43,2.99 l 8.645,2.24 -2.242,-2.52 z m 1.04,15.64 2,7 5,-5 -3.681,1 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="B_MTHFDm" d="m 1015.6,1949.68 c 2.01,9.32 2.01,9.32 2.01,9.32 l 2.24,-9.23 -2.15,2.27 z m 8.88,-13.98 c 9.8,-2.64 9.8,-2.64 9.8,-2.64 l -9.66,-3.11 2.36,2.94 z" stroke="#000000" - stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text7967-0-3-65-5-3-5-8-9-7-6-6-6-7-7" transform="rotate(0.813633,-137520.66,71342.096)" fill="#000000" @@ -7121,10 +6161,8 @@ letter-spacing="0em"><tspan x="0.48828101" y="11.1602" - id="tspan3012">NADPH</tspan></text> - <g - id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-2-8"> - <text + id="tspan3012">NADPH</tspan></text><g + id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-2-8"><text transform="rotate(0.777998,-143424.05,71247.391)" fill="#000000" xml:space="preserve" @@ -7135,8 +6173,7 @@ id="text3017"><tspan x="0.221874" y="11.1602" - id="tspan3015">NADP</tspan></text> - <text + id="tspan3015">NADP</tspan></text><text transform="rotate(0.777998,-143424.05,71247.391)" fill="#000000" xml:space="preserve" @@ -7147,11 +6184,8 @@ id="text3021"><tspan x="33.573399" y="11.1602" - id="tspan3019">⁺</tspan></text> - </g> - <g - id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-5-5-1-8"> - <text + id="tspan3019">⁺</tspan></text></g><g + id="text7967-0-3-65-1-2-4-9-6-3-3-1-0-5-5-1-8"><text transform="rotate(0.0309296,-3633941.1,2153828.2)" fill="#000000" xml:space="preserve" @@ -7162,8 +6196,7 @@ id="text3026"><tspan x="0.0617189" y="11.1602" - id="tspan3024">H</tspan></text> - <text + id="tspan3024">H</tspan></text><text transform="rotate(0.0309296,-3633941.1,2153828.2)" fill="#000000" xml:space="preserve" @@ -7174,9 +6207,7 @@ id="text3030"><tspan x="8.7335901" y="11.1602" - id="tspan3028">⁺</tspan></text> - </g> - <text + id="tspan3028">⁺</tspan></text></g><text id="text7967-0-3-65-5-3-5-8-9-7-3" fill="#000000" xml:space="preserve" @@ -7186,10 +6217,8 @@ letter-spacing="0em"><tspan x="873.35901" y="1896.21" - id="tspan3033">THF</tspan></text> - <g - id="text7967-0-3-65-1-2-4-9-6-3-1"> - <text + id="tspan3033">THF</tspan></text><g + id="text7967-0-3-65-1-2-4-9-6-3-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7202,8 +6231,7 @@ id="tspan3036">H</tspan><tspan x="887.35498" y="1919.3" - id="tspan3038">O</tspan></text> - <text + id="tspan3038">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7213,11 +6241,8 @@ id="text3044"><tspan x="883.13098" y="1919.3" - id="tspan3042">₂</tspan></text> - </g> - <g - id="text6979-5-4-1-7-9-30-5-8-5-5"> - <text + id="tspan3042">₂</tspan></text></g><g + id="text6979-5-4-1-7-9-30-5-8-5-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7228,8 +6253,7 @@ id="text3049"><tspan x="1911.3199" y="2093.55" - id="tspan3047">CO</tspan></text> - <text + id="tspan3047">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7240,11 +6264,8 @@ id="text3053"><tspan x="1935.34" y="2093.55" - id="tspan3051">₂</tspan></text> - </g> - <g - id="text6979-5-4-1-7-9-30-93-0-9-3"> - <text + id="tspan3051">₂</tspan></text></g><g + id="text6979-5-4-1-7-9-30-93-0-9-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7255,8 +6276,7 @@ id="text3058"><tspan x="1801.3199" y="2093.55" - id="tspan3056">CO</tspan></text> - <text + id="tspan3056">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7267,30 +6287,24 @@ id="text3062"><tspan x="1825.34" y="2093.55" - id="tspan3060">₂</tspan></text> - </g> - <path + id="tspan3060">₂</tspan></text></g><path id="B_CO2tm" fill-rule="evenodd" clip-rule="evenodd" d="m 1897.02,2091.7 c 9.22,-2.82 9.22,-2.82 9.22,-2.82 l -9.15,-3.02 2.26,2.95 z" stroke="#000000" - stroke-width="2.61244" /> - <path + stroke-width="2.61244" /><path id="R_CO2tm" d="m 1841.89,2089.37 h 58.85" stroke="#000000" - stroke-width="1.77153" /> - <path + stroke-width="1.77153" /><path id="F_CO2tm" fill-rule="evenodd" clip-rule="evenodd" d="m 1845.36,2085.75 c -8.78,3.96 -8.78,3.96 -8.78,3.96 l 9.46,1.85 -2.62,-2.64 z" stroke="#000000" - stroke-width="2.61244" /> - <g - id="Group 53"> - <text + stroke-width="2.61244" /><g + id="Group 53"><text id="text7967-0-3-6-2-7-4-34-0-4-2-9-11" transform="translate(1682.06,1623.15)" fill="#000000" @@ -7302,8 +6316,7 @@ letter-spacing="0em"><tspan x="0.375" y="14.5469" - id="tspan3068">NADH</tspan></text> - <text + id="tspan3068">NADH</tspan></text><text id="text7967-0-3-6-2-7-4-34-0-4-2-9-62" transform="translate(1916.06,1623.18)" fill="#000000" @@ -7315,10 +6328,8 @@ letter-spacing="0em"><tspan x="0.0390625" y="14.5469" - id="tspan3071">NADPH</tspan></text> - <g - id="text7009-4-5"> - <text + id="tspan3071">NADPH</tspan></text><g + id="text7009-4-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7329,8 +6340,7 @@ id="text3076"><tspan x="1723.02" y="1614.55" - id="tspan3074">NADP</tspan></text> - <text + id="tspan3074">NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7341,11 +6351,8 @@ id="text3080"><tspan x="1768.38" y="1614.55" - id="tspan3078">⁺</tspan></text> - </g> - <g - id="text7009-4-5-0"> - <text + id="tspan3078">⁺</tspan></text></g><g + id="text7009-4-5-0"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7356,8 +6363,7 @@ id="text3085"><tspan x="1791.35" y="1608.55" - id="tspan3083">NAD</tspan></text> - <text + id="tspan3083">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7368,16 +6374,12 @@ id="text3089"><tspan x="1826.04" y="1608.55" - id="tspan3087">⁺</tspan></text> - </g> - <path + id="tspan3087">⁺</tspan></text></g><path id="F_THD1m" d="m 1902.98,1635.71 c 9.66,-3.1 9.66,-3.1 9.66,-3.1 l -9.8,-2.65 2.5,2.82 z m -89.98,-18.21 -3,-4.5 -0.5,5.5 2,-1.5 z m 38,0 -2,-4 -2,5 2.5,-1.5 z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="text7009-4-5-0-8"> - <text + stroke-width="2.23952" /><g + id="text7009-4-5-0-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7388,8 +6390,7 @@ id="text3095"><tspan x="1843.42" y="1608.55" - id="tspan3093">H</tspan></text> - <text + id="tspan3093">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7400,16 +6401,12 @@ id="text3099"><tspan x="1854.98" y="1608.55" - id="tspan3097">⁺</tspan></text> - </g> - <path + id="tspan3097">⁺</tspan></text></g><path id="R_THD1m" d="M 1905.5,1632.5 H 1732 m 72,0 c 12,0 7.5,-14.74 7.5,-14.74 m -66.5,0 c -5.5,14.74 11,14.74 11,14.74 m 82,0 c 13.5,0 11,-14.74 11,-14.74 m 37,14.74 c -5,15 14,22 14,22" stroke="#000000" - stroke-width="2.02293" /> - <g - id="text7009-4-5-0-8-2"> - <text + stroke-width="2.02293" /><g + id="text7009-4-5-0-8-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7419,8 +6416,7 @@ id="text3105"><tspan x="1904.0601" y="1661.16" - id="tspan3103">H</tspan></text> - <text + id="tspan3103">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7430,14 +6426,9 @@ id="text3109"><tspan x="1912.73" y="1661.16" - id="tspan3107">⁺</tspan></text> - </g> - </g> - <g - id="Group 51"> - <g - id="text7967-0-3-9-1-34"> - <text + id="tspan3107">⁺</tspan></text></g></g><g + id="Group 51"><g + id="text7967-0-3-9-1-34"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7451,8 +6442,7 @@ id="tspan3113">H</tspan><tspan x="1556.2" y="1312.55" - id="tspan3115">O</tspan></text> - <text + id="tspan3115">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7466,11 +6456,8 @@ id="tspan3119">₂</tspan><tspan x="1568.65" y="1312.55" - id="tspan3121">₂</tspan></text> - </g> - <g - id="text7967-0-3-9-1-8-46"> - <text + id="tspan3121">₂</tspan></text></g><g + id="text7967-0-3-9-1-8-46"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7484,8 +6471,7 @@ id="tspan3126">2 H</tspan><tspan x="1804.05" y="1312.55" - id="tspan3128">O</tspan></text> - <text + id="tspan3128">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7496,9 +6482,7 @@ id="text3134"><tspan x="1798.42" y="1312.55" - id="tspan3132">₂</tspan></text> - </g> - <text + id="tspan3132">₂</tspan></text></g><text id="text7967-0-3-2-6-6-4-4-3-5" fill="#000000" xml:space="preserve" @@ -7509,10 +6493,8 @@ letter-spacing="0em"><tspan x="1584.48" y="1289.55" - id="tspan3137">2 GSH</tspan></text> - <g - id="text7967-0-3-0-0-3"> - <text + id="tspan3137">2 GSH</tspan></text><g + id="text7967-0-3-0-0-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7523,8 +6505,7 @@ id="text3142"><tspan x="1407.36" y="1309.55" - id="tspan3140">O</tspan></text> - <text + id="tspan3140">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7535,8 +6516,7 @@ id="text3146"><tspan x="1419.8101" y="1309.55" - id="tspan3144">₂</tspan></text> - <text + id="tspan3144">₂</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7547,11 +6527,8 @@ id="text3150"><tspan x="1425.4399" y="1309.55" - id="tspan3148">⁻</tspan></text> - </g> - <g - id="text7967-0-3-0-1-1"> - <text + id="tspan3148">⁻</tspan></text></g><g + id="text7967-0-3-0-1-1"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7561,8 +6538,7 @@ id="text3155"><tspan x="1437.15" y="1283.16" - id="tspan3153">O</tspan></text> - <text + id="tspan3153">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7572,8 +6548,7 @@ id="text3159"><tspan x="1446.49" y="1283.16" - id="tspan3157">₂</tspan></text> - <text + id="tspan3157">₂</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7583,11 +6558,8 @@ id="text3163"><tspan x="1450.72" y="1283.16" - id="tspan3161">⁻</tspan></text> - </g> - <g - id="text7967-0-3-9-1-7-4"> - <text + id="tspan3161">⁻</tspan></text></g><g + id="text7967-0-3-9-1-7-4"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7597,8 +6569,7 @@ id="text3168"><tspan x="1467.1899" y="1286.16" - id="tspan3166">2 H</tspan></text> - <text + id="tspan3166">2 H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7608,11 +6579,8 @@ id="text3172"><tspan x="1485.88" y="1286.16" - id="tspan3170">⁺</tspan></text> - </g> - <g - id="text7967-0-3-9-1-2-15"> - <text + id="tspan3170">⁺</tspan></text></g><g + id="text7967-0-3-9-1-2-15"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7622,8 +6590,7 @@ id="text3177"><tspan x="1508.46" y="1278.16" - id="tspan3175">O</tspan></text> - <text + id="tspan3175">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -7633,19 +6600,15 @@ id="text3181"><tspan x="1517.8" y="1278.16" - id="tspan3179">₂</tspan></text> - 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id="tspan4307">⁺</tspan></text> - </g> - <g - id="text7967-0-3-9-1-2-1-3-8-9-5-0"> - <text + id="tspan4307">⁺</tspan></text></g><g + id="text7967-0-3-9-1-2-1-3-8-9-5-0"><text transform="translate(1061,993)" fill="#000000" xml:space="preserve" @@ -11716,8 +10069,7 @@ id="text4314"><tspan x="0.41562501" y="14.5469" - id="tspan4312">H</tspan></text> - <text + id="tspan4312">H</tspan></text><text transform="translate(1061,993)" fill="#000000" xml:space="preserve" @@ -11729,9 +10081,7 @@ id="text4318"><tspan x="11.9781" y="14.5469" - id="tspan4316">⁺</tspan></text> - </g> - <text + id="tspan4316">⁺</tspan></text></g><text id="text7967-0-3-9-1-2-1-3-4-8-3-9" transform="translate(1049,1058)" fill="#000000" @@ -11743,21 +10093,16 @@ letter-spacing="0em"><tspan x="0.156251" y="14.5469" - id="tspan4321">Glu</tspan></text> - <path + id="tspan4321">Glu</tspan></text><path id="R_ASPGLUm" d="m 1100.62,1117 0.15,-153 m 0,97.62 c -1.61,10.83 -15.26,8.08 -15.26,8.08 m -3.51,-68.2 c 18.62,0 18.62,13 18.62,13 M 1082,973 c 18.62,0 18.62,19 18.62,19 m 0.15,46.19 c -1.61,10.83 -15.26,8.08 -15.26,8.08" stroke="#000000" - stroke-width="2.81982" /> - <path + stroke-width="2.81982" /><path id="F_ASPGLUm" d="m 1104.5,966 -4,-2.5 -3.5,2.5 3.5,-8 z m -12.4,106.14 -13.23,-2.73 13.17,-2.89 -3.27,2.83 z m -3.28,-22.8 -13.24,-2.73 13.18,-2.89 -3.27,2.83 z" stroke="#000000" - stroke-width="2.57925" /> - </g> - <g - id="Group 52"> - <text + stroke-width="2.57925" /></g><g + id="Group 52"><text id="text4191" fill="#000000" xml:space="preserve" @@ -11768,18 +10113,15 @@ letter-spacing="0em"><tspan x="1404.08" y="2045.55" - id="tspan4327">AcAcCoA</tspan></text> - <path + id="tspan4327">AcAcCoA</tspan></text><path id="F_ACACT1m" d="m 1367.52,2039.22 c -9.22,2.82 -9.22,2.82 -9.22,2.82 l 9.15,3.03 -2.26,-2.95 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path id="R_ACACT1m" d="m 1367.32,2041.75 h 33.25 m -22.08,0.15 c 7.09,-1.89 6.27,-20.61 6.27,-20.61" stroke="#000000" - stroke-width="1.57473" /> - <text + stroke-width="1.57473" /><text id="text4203" fill="#000000" xml:space="preserve" @@ -11789,8 +10131,7 @@ letter-spacing="0em"><tspan x="1373.3199" y="2018.16" - id="tspan4332">CoA</tspan></text> - <text + id="tspan4332">CoA</tspan></text><text id="text4207" fill="#000000" xml:space="preserve" @@ -11801,23 +10142,19 @@ letter-spacing="0em"><tspan x="1288.4301" y="2045.55" - id="tspan4335">2 AcCoA</tspan></text> - <path + id="tspan4335">2 AcCoA</tspan></text><path id="F_HACD1m" d="m 1492.61,2036.41 c -9.61,3.25 -9.61,3.25 -9.61,3.25 l 9.84,2.5 -2.54,-2.78 z m 10.89,-10.91 -1.5,-4.5 -1.5,4.5 1.5,-0.5 z" stroke="#000000" - stroke-width="2.66667" /> - <path + stroke-width="2.66667" /><path id="R_HACD1m" d="M 1579.5,2039.24 C 1595,2039.18 1595,2026 1595,2026 m -103.17,13.58 c 0,0 12.6,-0.05 20.67,-0.08 m 107.34,-0.42 c 0,0 -65.42,0.25 -107.34,0.42 M 1539,2026 c 0,13.39 12,13.35 12,13.35 m -38.5,0.15 C 1500,2039.54 1502,2026 1502,2026" stroke="#000000" - stroke-width="1.54275" /> - <path + stroke-width="1.54275" /><path id="B_HACD1m" d="m 1596,2022 -2.5,4.5 2,-0.5 1.5,1 z m 20.54,13.45 2.55,2.78 -2.32,2.97 9.61,-3.25 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text5606-3" fill="#000000" xml:space="preserve" @@ -11827,10 +10164,8 @@ letter-spacing="0em"><tspan x="1486.49" y="2015.16" - id="tspan4341">NADH</tspan></text> - <g - id="text5606-3_2"> - <text + id="tspan4341">NADH</tspan></text><g + id="text5606-3_2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -11840,8 +10175,7 @@ id="text4346"><tspan x="1582.22" y="2015.16" - id="tspan4344">NAD</tspan></text> - <text + id="tspan4344">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -11851,11 +10185,8 @@ id="text4350"><tspan x="1607.5699" y="2015.16" - id="tspan4348">⁺</tspan></text> - </g> - <g - id="text5606-3_3"> - <text + id="tspan4348">⁺</tspan></text></g><g + id="text5606-3_3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -11865,8 +10196,7 @@ id="text4355"><tspan x="1532.0601" y="2024.16" - id="tspan4353">H</tspan></text> - <text + id="tspan4353">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -11876,75 +10206,51 @@ id="text4359"><tspan x="1540.73" y="2024.16" - id="tspan4357">⁺</tspan></text> - </g> - <g - id="use1272-2"> - <path + id="tspan4357">⁺</tspan></text></g><g + id="use1272-2"><path id="circle77227-5" d="m 1647.38,2048.76 c 6.29,0 11.38,-5.09 11.38,-11.38 0,-6.28 -5.09,-11.38 -11.38,-11.38 -6.28,0 -11.38,5.1 -11.38,11.38 0,6.29 5.1,11.38 11.38,11.38 z" fill="#aaccee" stroke="#000000" - stroke-width="1.1381" /> - <g - id="path77229-7"> - <path + stroke-width="1.1381" /><g + id="path77229-7"><path d="m 1639.41,2029.41 15.94,15.94 z" fill="#aaccee" - id="path4363" /> - <path + id="path4363" /><path d="m 1639.41,2029.41 15.94,15.94" stroke="#000000" stroke-width="1.1381" - id="path4365" /> - </g> - <g - id="path77231-8"> - <path + id="path4365" /></g><g + id="path77231-8"><path d="m 1639.41,2045.35 15.94,-15.94 z" fill="#aaccee" - id="path4368" /> - <path + id="path4368" /><path d="m 1639.41,2045.35 15.94,-15.94" stroke="#000000" stroke-width="1.1381" - id="path4370" /> - </g> - </g> - <g - id="use1272-2-48"> - <path + id="path4370" /></g></g><g + id="use1272-2-48"><path id="circle77227-5-9" d="m 1561.38,1925.76 c 6.29,0 11.38,-5.09 11.38,-11.38 0,-6.28 -5.09,-11.38 -11.38,-11.38 -6.28,0 -11.38,5.1 -11.38,11.38 0,6.29 5.1,11.38 11.38,11.38 z" fill="#aaccee" stroke="#000000" - stroke-width="1.1381" /> - <g - id="path77229-7-3"> - <path + stroke-width="1.1381" /><g + id="path77229-7-3"><path d="m 1553.41,1906.41 15.94,15.94 z" fill="#aaccee" - id="path4375" /> - <path + id="path4375" /><path d="m 1553.41,1906.41 15.94,15.94" stroke="#000000" stroke-width="1.1381" - id="path4377" /> - </g> - <g - id="path77231-8-4"> - <path + id="path4377" /></g><g + id="path77231-8-4"><path d="m 1553.41,1922.35 15.94,-15.94 z" fill="#aaccee" - id="path4380" /> - <path + id="path4380" /><path d="m 1553.41,1922.35 15.94,-15.94" stroke="#000000" stroke-width="1.1381" - id="path4382" /> - </g> - </g> - <text + id="path4382" /></g></g><text id="text14626" transform="translate(1421.02,1905.07)" fill="#000000" @@ -11956,8 +10262,7 @@ letter-spacing="0em"><tspan x="0.375" y="14.5469" - id="tspan4386">HMGCoA</tspan></text> - <text + id="tspan4386">HMGCoA</tspan></text><text id="text14626-4" transform="translate(1579.62,1906.11)" fill="#000000" @@ -11969,8 +10274,7 @@ letter-spacing="0em"><tspan x="0.46093801" y="14.5469" - id="tspan4389">Leu, 4mop</tspan></text> - <text + id="tspan4389">Leu, 4mop</tspan></text><text id="text14626-4-3" transform="translate(1620.02,2006.1)" fill="#000000" @@ -11982,13 +10286,11 @@ letter-spacing="0em"><tspan x="0.125" y="14.5469" - id="tspan4392">Lys, 2oxoadp</tspan></text> - <path + id="tspan4392">Lys, 2oxoadp</tspan></text><path id="F_HMGCOASm" d="m 1458.03,1929 -2.49,9.84 2.77,-2.55 2.97,2.33 z m -13.03,13 -4,2 4.5,1.5 -0.5,-2 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="AcCoA" fill="#000000" xml:space="preserve" @@ -11998,10 +10300,8 @@ letter-spacing="0em"><tspan x="1405.3199" y="2000.16" - id="tspan4396">AcCoA</tspan></text> - <g - id="H2O_3"> - <text + id="tspan4396">AcCoA</tspan></text><g + id="H2O_3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12014,8 +10314,7 @@ id="tspan4399">H</tspan><tspan x="1432.28" y="2024.16" - id="tspan4401">O</tspan></text> - <text + id="tspan4401">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12025,9 +10324,7 @@ id="text4407"><tspan x="1428.05" y="2024.16" - id="tspan4405">₂</tspan></text> - </g> - <text + id="tspan4405">₂</tspan></text></g><text id="text5643" fill="#000000" xml:space="preserve" @@ -12037,10 +10334,8 @@ letter-spacing="0em"><tspan x="1413.3199" y="1948.16" - id="tspan4410">CoA</tspan></text> - <g - id="text5643_2"> - <text + id="tspan4410">CoA</tspan></text><g + id="text5643_2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12050,8 +10345,7 @@ id="text4415"><tspan x="1424.0601" y="1969.16" - id="tspan4413">H</tspan></text> - <text + id="tspan4413">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12061,16 +10355,12 @@ id="text4419"><tspan x="1432.73" y="1969.16" - id="tspan4417">⁺</tspan></text> - </g> - <path + id="tspan4417">⁺</tspan></text></g><path id="R_HMGCOASm" d="m 1445.26,1997.26 c 10.86,2.59 13.33,-9 13.33,-9 m 0,-51.5 c 0,0 0,23.95 0,38 m 0,55.74 c 0,0 0,-10.29 0,-22.5 m 0,-55.24 c -3.33,-10.58 -13.33,-9 -13.33,-9 m 13.33,31 c -4.83,-13.5 -13.33,-11 -13.33,-11 m 13.33,11 c 0,7.87 0,21.45 0,33.24 m 0,0 c 0,13 -13.33,13 -13.33,13" stroke="#000000" - stroke-width="1.67988" /> - <g - id="text14606"> - <text + stroke-width="1.67988" /><g + id="text14606"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12083,8 +10373,7 @@ id="tspan4423">H</tspan><tspan x="1525.4399" y="1936.45" - id="tspan4425">O</tspan></text> - <text + id="tspan4425">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12094,34 +10383,26 @@ id="text4431"><tspan x="1521.22" y="1936.45" - id="tspan4429">₂</tspan></text> - </g> - <path + id="tspan4429">₂</tspan></text></g><path id="F_MGCHrm" d="m 1504.42,1917.46 c -9.67,-3.1 -9.67,-3.1 -9.67,-3.1 l 9.8,-2.65 -2.5,2.82 z" stroke="#000000" - stroke-width="2.66667" /> - <path + stroke-width="2.66667" /><path id="R_MGCHrm" d="M 1544.78,1913.83 H 1502 m 17,0 c 6.36,2.33 5.5,11.17 5.5,11.17" stroke="#000000" - stroke-width="1.40903" /> - </g> - <g + stroke-width="1.40903" /></g><g id="Group 44-2" - transform="matrix(-1,0,0,1,1184.0089,-318.46971)"> - <path + transform="matrix(-1,0,0,1,1184.0089,-318.46971)"><path id="R_3SALAASPm" d="m 472.61681,1393.7212 c 6.57,1.84 5.173,17.14 5.173,17.14 m -373.46727,37.0235 82.09608,-0.3524 -0.48103,-55.3491 315.51322,0.628 m -53.367,17.87 c -2.805,-10.81 5.315,-17.18 5.315,-17.18" stroke="#000000" stroke-width="1.48938" - sodipodi:nodetypes="cccccccc" /> - <path + sodipodi:nodetypes="cccccccc" /><path id="F_3SALAASPm" d="m 494.94532,1391.6435 c 9.762,2.78 9.762,2.78 9.762,2.78 l -9.705,2.97 2.405,-2.9 z m -45.178,18.58 c -2.216,6.88 -2.216,6.88 -2.216,6.88 l -2.325,-6.86 2.284,1.71 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text5323-2-5-9" transform="matrix(-0.99999798,0.00200905,0.00200905,0.99999798,0,0)" fill="#000000" @@ -12135,8 +10416,7 @@ y="1385.1702"><tspan x="-535.98669" y="1399.717" - id="tspan4189-3">asp</tspan></text> - <text + id="tspan4189-3">asp</tspan></text><text id="text5323-2-5-9-8-5" transform="matrix(-0.99999798,0.00200905,0.00200905,0.99999798,0,0)" fill="#000000" @@ -12150,8 +10430,7 @@ y="1416.9109"><tspan x="-502.79907" y="1431.4578" - id="tspan4189-3-6-0">3sala</tspan></text> - <text + id="tspan4189-3-6-0">3sala</tspan></text><text id="text5323-2-5-9-8-5-2" transform="matrix(-0.99999798,0.00200905,0.00200905,0.99999798,0,0)" fill="#000000" @@ -12167,8 +10446,7 @@ inkscape:transform-center-y="6.5900721"><tspan x="-442.40088" y="1431.573" - id="tspan4189-3-6-0-8">3sala</tspan></text> - <text + id="tspan4189-3-6-0-8">3sala</tspan></text><text id="text5397" style="font-style:normal;font-weight:normal;font-size:13.3716px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1.06973px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="matrix(-1.0010463,-0.00184929,-0.00185317,0.99895137,0,0)" @@ -12179,8 +10457,7 @@ style="font-size:13.3716px;stroke-width:1.06973px" x="-247.01941" y="1514.3774" - sodipodi:role="line">H</tspan></text> - <text + sodipodi:role="line">H</tspan></text><text id="text5401" style="font-style:normal;font-weight:normal;font-size:13.3716px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1.06973px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" transform="matrix(-1.0010408,0.00378594,0.00379389,0.99894593,0,0)" @@ -12193,26 +10470,22 @@ y="1461.7429" sodipodi:role="line">H<tspan id="tspan5405-6" - 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stroke-width="2.32327" /> - </g> - </g> - <g - id="Group 145"> - <path + stroke-width="2.32327" /></g></g><g + id="Group 145"><path id="F_NH4t" fill-rule="evenodd" clip-rule="evenodd" d="m 1807.89,-20.861278 -2.95,-9.2406 -2.94,9.2406 2.94,-2.3101 z" stroke="#000000" - stroke-width="3.3745" /> - <path + stroke-width="3.3745" /><path id="R_NH4t" d="M 1805.39,531.5 V -20.663962" stroke="#000000" - stroke-width="2.39359" /> - <g - id="M_Glc-8-6-7-8"> - <text + stroke-width="2.39359" /><g + id="M_Glc-8-6-7-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12639,8 +10853,7 @@ id="text4482"><tspan x="1820.61" y="547.547" - id="tspan4480">3</tspan></text> - <text + id="tspan4480">3</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -12651,30 +10864,21 @@ id="text4486"><tspan x="1797.48" y="547.547" - id="tspan4484">NH</tspan></text> - </g> - </g> - </g> - </g> - <g + id="tspan4484">NH</tspan></text></g></g></g></g><g id="path_fattyacids_betaox" - transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"> - <g + transform="matrix(0.99609327,0,0,0.99818223,-21.178407,43.370327)"><g id="g29" - inkscape:label="box_fattyacids_betaox"> - <path + inkscape:label="box_fattyacids_betaox"><path id="Rectangle 3_8" d="m 1859,1846 v -84 c 0,-6.63 -5.37,-12 -12,-12 H 1804.06 1331 c -6.63,0 -12,5.37 -12,12 v 84 c 0,6.63 5.37,12 12,12 h 516 c 6.63,0 12,-5.37 12,-12 z" fill="#cbe048" - fill-opacity="0.1" /> - <path + fill-opacity="0.1" /><path id="Rectangle 2_8" d="M 1580.0627,1737 H 1835 c 6.63,0 12,5.37 12,12 v 84.5 c 0,6.63 -5.37,12 -12,12 h -516 c -6.63,0 -12,-5.37 -12,-12 V 1749 c 0,-6.63 5.37,-12 12,-12 h 8.5" stroke="#cbe048" stroke-width="4" stroke-linecap="round" - sodipodi:nodetypes="cssssssssc" /> - <text + sodipodi:nodetypes="cssssssssc" /><text id="Title_8" fill="#000000" xml:space="preserve" @@ -12685,18 +10889,14 @@ letter-spacing="0em"><tspan x="1336" y="1743.4301" - id="tspan756">Fatty acids β-oxidation </tspan></text> - 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id="tspan4512-7">Carn</tspan></text> - <text + id="tspan4512-7">Carn</tspan></text><text id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-8-54-0-2-2-5-6" transform="translate(1684,1759)" fill="#000000" @@ -12858,8 +11041,7 @@ letter-spacing="0em"><tspan x="0.32226601" y="11.1602" - id="tspan4515">CoA</tspan></text> - <text + id="tspan4515">CoA</tspan></text><text id="text7967-0-3-65-1-2-4-9-6-3-3-1-3-8-54-0-2-2-5-6-5" fill="#000000" xml:space="preserve" @@ -12871,8 +11053,7 @@ y="1751.2466"><tspan x="1915.3201" y="1762.4067" - id="tspan4515-9">CoA</tspan></text> - <text + id="tspan4515-9">CoA</tspan></text><text id="text7967-0-3-9-14-8-1-9-3-4-5" fill="#000000" xml:space="preserve" @@ -12883,8 +11064,7 @@ letter-spacing="0em"><tspan x="1324.4301" y="1803.55" - id="tspan4518">8 AcCoA</tspan></text> - <text + id="tspan4518">8 AcCoA</tspan></text><text id="text7967-0-3-65-5-3-5-1-2-8-1-2-5" transform="rotate(0.250513,-404506.17,354948.12)" fill="#000000" @@ -12895,10 +11075,8 @@ letter-spacing="0em"><tspan x="0.31835899" y="11.1602" - id="tspan4521">7 FAD</tspan></text> - <g - id="text7967-0-3-65-5-3-5-1-2-8-1-2-56"> - <text + id="tspan4521">7 FAD</tspan></text><g + id="text7967-0-3-65-5-3-5-1-2-8-1-2-56"><text transform="rotate(0.250513,-404529.67,344198.59)" fill="#000000" xml:space="preserve" @@ -12909,8 +11087,7 @@ id="text4526"><tspan x="0.21406201" y="11.1602" - id="tspan4524">7 NAD</tspan></text> - <text + id="tspan4524">7 NAD</tspan></text><text transform="rotate(0.250513,-404529.67,344198.59)" fill="#000000" xml:space="preserve" @@ -12921,9 +11098,7 @@ id="text4530"><tspan x="35.5812" y="11.1602" - id="tspan4528">⁺</tspan></text> - </g> - <text + id="tspan4528">⁺</tspan></text></g><text id="text7967-0-3-65-5-3-5-1-2-8-1-2-8" transform="rotate(0.250513,-404553.17,333449.05)" fill="#000000" @@ -12934,10 +11109,8 @@ letter-spacing="0em"><tspan x="0.3125" y="11.1602" - id="tspan4533">7 CoA</tspan></text> - <g - id="text7967-0-3-65-5-3-5-1-2-8-1-2-6"> - <text + id="tspan4533">7 CoA</tspan></text><g + id="text7967-0-3-65-5-3-5-1-2-8-1-2-6"><text transform="rotate(0.250513,-404577.17,322470.81)" fill="#000000" xml:space="preserve" @@ -12951,8 +11124,7 @@ id="tspan4536">7 H</tspan><tspan x="23.287701" y="11.1602" - 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fill="#25ca25" /> - </g> - <g + fill="#25ca25" /></g><g id="g36" inkscape:label="aa_synthesis" - transform="matrix(1.0039221,0,0,1.0018211,-10.330425,-14.030774)"> - <g + transform="matrix(1.0039221,0,0,1.0018211,-10.330425,-14.030774)"><g id="Group 91" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text id="text1172" fill="#000000" xml:space="preserve" @@ -13179,13 +11321,11 @@ letter-spacing="0em"><tspan x="740.09399" y="545.547" - id="tspan5022">CySS</tspan></text> - <path + id="tspan5022">CySS</tspan></text><path id="R_CYSGLTH" d="m 804.5,528.5 c 0,11.852 21.595,12.314 21.595,12.314 25.405,0 25.405,-12.314 25.405,-12.314 m -67,12.314 h 83.191" stroke="#000000" - stroke-width="1.489" /> - <text + stroke-width="1.489" /><text id="text1178" fill="#000000" xml:space="preserve" @@ -13195,8 +11335,7 @@ letter-spacing="0em"><tspan x="782.48199" y="524.15997" - id="tspan5026">2 GSH</tspan></text> - 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stroke-width="2.66667" /> - <g - id="text1260"> - <text + stroke-width="2.66667" /><g + id="text1260"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13354,8 +11473,7 @@ id="tspan5070">H</tspan><tspan x="725.27802" y="575.15997" - id="tspan5072">O</tspan></text> - <text + id="tspan5072">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13365,11 +11483,8 @@ id="text5078"><tspan x="721.05402" y="575.15997" - id="tspan5076">₂</tspan></text> - </g> - <g - id="text1264"> - <text + id="tspan5076">₂</tspan></text></g><g + id="text1264"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13379,8 +11494,7 @@ id="text5083"><tspan x="684.32397" y="575.15997" - id="tspan5081">NH</tspan></text> - <text + id="tspan5081">NH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13390,19 +11504,15 @@ id="text5088"><tspan x="701.66803" y="575.15997" - id="tspan5085">₃</tspan></text> - </g> - <path + id="tspan5085">₃</tspan></text></g><path id="F_CystinePyruvate" d="m 692.073,556.576 c 2.216,6.889 2.216,6.889 2.216,6.889 l 2.325,-6.86 -2.284,1.704 z M 676.762,538 C 667,540.779 667,540.779 667,540.779 l 9.705,2.973 -2.405,-2.9 z" stroke="#000000" - 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id="tspan5109">PPi</tspan></text> - <text + id="tspan5109">PPi</tspan></text><text id="ATP" transform="rotate(0.638475,-57150.458,50856.244)" fill="#000000" @@ -13492,8 +11592,7 @@ letter-spacing="0em"><tspan x="0.27343801" y="11.1602" - id="tspan5112">ATP</tspan></text> - <text + id="tspan5112">ATP</tspan></text><text id="Gln" transform="rotate(0.638475,-59032.947,51225.694)" fill="#000000" @@ -13504,10 +11603,8 @@ letter-spacing="0em"><tspan x="0.15429699" y="11.1602" - id="tspan5115">Gln</tspan></text> - <g - id="H2O_4"> - <text + id="tspan5115">Gln</tspan></text><g + id="H2O_4"><text transform="rotate(0.638475,-54817.282,50843.244)" fill="#000000" xml:space="preserve" @@ -13521,8 +11618,7 @@ id="tspan5118">H</tspan><tspan x="13.2779" y="11.1602" - id="tspan5120">O</tspan></text> - <text + id="tspan5120">O</tspan></text><text transform="rotate(0.638475,-54817.282,50843.244)" fill="#000000" xml:space="preserve" @@ -13533,16 +11629,12 @@ id="text5126"><tspan x="9.0541096" y="11.1602" - id="tspan5124">₂</tspan></text> - </g> - <path + id="tspan5124">₂</tspan></text></g><path id="R_ASNS1" d="M 603.542,529.162 V 677 m 10e-4,-43.5 c -10e-4,13 -14.736,13 -14.736,13 m 0,-81.5 c 15.76,0 14.735,16.5 14.735,16.5 m -14.735,39 c 0,0 14.735,0 14.735,-13 0,0 1.025,-16.5 -14.734,-16.5 m 14.734,65.5 c 0,13 -14.735,13 -14.735,13 m 0,-130.5 c 15.76,0 14.735,16.5 14.735,16.5" stroke="#000000" - stroke-width="2.99247" /> - <g - id="text7967-0-3-65-1-3-2-82-8-2"> - <text + stroke-width="2.99247" /><g + id="text7967-0-3-65-1-3-2-82-8-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13555,8 +11647,7 @@ id="tspan5130">H</tspan><tspan x="643.27802" y="607.15997" - id="tspan5132">O</tspan></text> - <text + id="tspan5132">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13566,11 +11657,8 @@ id="text5138"><tspan x="639.05402" y="607.15997" - id="tspan5136">₂</tspan></text> - </g> - <g - id="text7967-0-3-65-1-3-2-82-8-3"> - <text + id="tspan5136">₂</tspan></text></g><g + id="text7967-0-3-65-1-3-2-82-8-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13580,8 +11668,7 @@ id="text5143"><tspan x="637.32397" y="639.15997" - 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id="tspan5188">NADPH</tspan></text> - <g - id="text3932"> - <text + id="tspan5188">NADPH</tspan></text><g + id="text3932"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13752,8 +11814,7 @@ id="text5193"><tspan x="1215.22" y="653.15997" - id="tspan5191">NAD</tspan></text> - <text + id="tspan5191">NAD</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13763,11 +11824,8 @@ id="text5197"><tspan x="1240.5699" y="653.15997" - id="tspan5195">⁺</tspan></text> - </g> - <g - id="text3938"> - <text + id="tspan5195">⁺</tspan></text></g><g + id="text3938"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13777,8 +11835,7 @@ id="text5202"><tspan x="1301.22" y="653.15997" - id="tspan5200">NADP</tspan></text> - <text + id="tspan5200">NADP</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13788,11 +11845,8 @@ id="text5206"><tspan x="1334.5699" y="653.15997" - id="tspan5204">⁺</tspan></text> - </g> - 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id="tspan5233">₃</tspan></text> - </g> - <text + id="tspan5233">₃</tspan></text></g><text id="text3514-0" fill="#000000" xml:space="preserve" @@ -13894,10 +11932,8 @@ letter-spacing="0em"><tspan x="1390.16" y="587.547" - id="tspan5238">Gln</tspan></text> - <g - id="text3565-0"> - <text + id="tspan5238">Gln</tspan></text><g + id="text3565-0"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13910,8 +11946,7 @@ id="tspan5241">H</tspan><tspan x="1369.28" y="620.15997" - id="tspan5243">O</tspan></text> - <text + id="tspan5243">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13921,11 +11956,8 @@ id="text5249"><tspan x="1365.05" y="620.15997" - id="tspan5247">₂</tspan></text> - </g> - <g - id="text3687-9"> - <text + id="tspan5247">₂</tspan></text></g><g + id="text3687-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -13935,8 +11967,7 @@ id="text5254"><tspan x="1433.13" y="667.422" - id="tspan5252">NH</tspan></text> - 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style="stroke-width:0.997137">propCoA</tspan></text> - <text + style="stroke-width:0.997137">propCoA</tspan></text><text id="NADH_4" transform="matrix(0.99593228,0.01794569,-0.01790813,0.9980209,1351.2809,746.67107)" fill="#000000" @@ -15004,11 +12868,9 @@ inkscape:label="NADH"><tspan x="0.49023399" y="11.1602" - id="tspan5585">NADH</tspan></text> - <g + id="tspan5585">NADH</tspan></text><g id="CO2_7" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text transform="rotate(1.03014,-40164.423,73685.313)" fill="#000000" xml:space="preserve" @@ -15019,8 +12881,7 @@ id="text5592"><tspan x="0.49023399" y="11.1602" - id="tspan5588">CO</tspan></text> - <text + id="tspan5588">CO</tspan></text><text transform="rotate(1.03014,-40164.423,73685.313)" fill="#000000" xml:space="preserve" @@ -15031,9 +12892,7 @@ id="text5596"><tspan x="18.502001" y="11.1602" - id="tspan5594">₂</tspan></text> - </g> - <text + id="tspan5594">₂</tspan></text></g><text id="text4799" transform="matrix(0.99609327,0,0,0.99818223,1295.2504,752.66012)" fill="#000000" @@ -15045,8 +12904,7 @@ inkscape:label="CoA"><tspan x="0.32226601" y="11.1602" - 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transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)" /> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)" /><text id="text7967-0-3-6-2-7-4-34-4-71-2-2-8-6-1" fill="#000000" xml:space="preserve" @@ -15087,12 +12942,10 @@ x="1237.9861" y="780.33734" id="tspan5572" - style="stroke-width:0.997137">2obut</tspan></text> - <g + style="stroke-width:0.997137">2obut</tspan></text><g id="text7967-0-3-65-1-3-2-82-8-1-7-8-1-8-6" inkscape:label="NH3" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -15102,8 +12955,7 @@ id="text5550"><tspan x="1199.8199" y="746.15997" - id="tspan5548">NH</tspan></text> - <text + id="tspan5548">NH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -15113,21 +12965,17 @@ id="text5554"><tspan x="1217.17" y="746.15997" - id="tspan5552">₃</tspan></text> - </g> - <path + id="tspan5552">₃</tspan></text></g><path id="F_THRD_L" d="m 1220.28,768.501 c 8.44,-2.947 8.44,-2.947 8.44,-2.947 l -8.63,-2.288 2.23,2.535 z m -9.88,-10.369 c -1.93,-9.34 -1.93,-9.34 -1.93,-9.34 l -2.33,9.208 2.18,-2.252 z" stroke="#000000" stroke-width="2.23952" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)" /> - <path + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)" /><path id="R_THRD_L" d="M 1221.14,766.679 H 1194 c 14.5,0 14.5,-10.679 14.5,-10.679" stroke="#000000" stroke-width="1.91264" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)" /> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)" /><text id="Thr" fill="#000000" xml:space="preserve" @@ -15142,12 +12990,9 @@ x="1174.0597" y="780.33734" id="tspan5545" - style="stroke-width:0.997137">Thr</tspan></text> - </g> - <g + style="stroke-width:0.997137">Thr</tspan></text></g><g id="Group 109" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - 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stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text4606" transform="translate(1107,579)" fill="#000000" @@ -15185,8 +13026,7 @@ letter-spacing="0em"><tspan x="0.32617199" y="11.1602" - id="tspan5607">AKG</tspan></text> - <text + id="tspan5607">AKG</tspan></text><text id="text4610" transform="translate(1080,579)" fill="#000000" @@ -15197,12 +13037,9 @@ letter-spacing="0em"><tspan x="0.15429699" y="11.1602" - id="tspan5610">Glu</tspan></text> - </g> - <g + id="tspan5610">Glu</tspan></text></g><g id="Group 117" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text id="text6724-4" transform="translate(1134,652.331)" fill="#000000" @@ -15214,13 +13051,11 @@ letter-spacing="0em"><tspan x="0.14843801" y="14.5469" - id="tspan5614">3mob</tspan></text> - <path + id="tspan5614">3mob</tspan></text><path id="F_VALTA" d="m 1110.54,653.029 c -2.22,-6.889 -2.22,-6.889 -2.22,-6.889 l -2.32,6.86 2.28,-1.704 z m 11.12,11.784 c 9.67,-3.081 9.67,-3.081 9.67,-3.081 l -9.79,-2.67 2.49,2.824 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text6736" transform="translate(1022,652)" fill="#000000" @@ -15232,13 +13067,11 @@ letter-spacing="0em"><tspan x="0.42968801" y="14.5469" - id="tspan5618">Val</tspan></text> - <path + id="tspan5618">Val</tspan></text><path id="R_VALTA" d="m 1073,651.5 c 0,11.5 17.09,10.771 17.09,10.771 18.41,0 18.41,-10.771 18.41,-10.771 m -51,10.771 h 65.17" stroke="#000000" - stroke-width="1.48337" /> - <text + stroke-width="1.48337" /><text id="text6742" transform="translate(1099,632)" fill="#000000" @@ -15249,8 +13082,7 @@ letter-spacing="0em"><tspan x="0.15429699" y="11.1602" - id="tspan5622">Glu</tspan></text> - <text + id="tspan5622">Glu</tspan></text><text id="text6746" fill="#000000" xml:space="preserve" @@ -15260,51 +13092,36 @@ letter-spacing="0em"><tspan x="1060.33" y="643.15997" - id="tspan5625">AKG</tspan></text> - <path + id="tspan5625">AKG</tspan></text><path id="B_VALTA" d="m 1058.67,659.061 c -9.67,3.081 -9.67,3.081 -9.67,3.081 l 9.79,2.671 -2.49,-2.825 z m 16.65,-5.915 c -2.22,-6.889 -2.22,-6.889 -2.22,-6.889 l -2.32,6.86 2.28,-1.704 z" stroke="#000000" - 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stroke-width="1.90151" /> - <path + stroke-width="1.90151" /><path id="F_CYSTS" d="m 688.992,685.79 c 0.893,-3.263 1.787,-6.527 2.68,-9.79 1.024,3.225 2.048,6.449 3.071,9.674 -0.974,-0.792 -1.949,-1.583 -2.924,-2.375 -0.943,0.83 -1.885,1.661 -2.827,2.491 z m -9.014,12.506 C 671,695.077 671,695.077 671,695.077 l 9.443,-1.013 -2.535,1.84 z" stroke="#000000" - stroke-width="2.23952" /> - <g - id="text7967-0-3-65-1-3-2-82-8-1-2-8-9-6-9-4"> - <text + stroke-width="2.23952" /><g + id="text7967-0-3-65-1-3-2-82-8-1-2-8-9-6-9-4"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -15534,8 +13313,7 @@ id="tspan5704">H</tspan><tspan x="658.27802" y="699.15997" - id="tspan5706">O</tspan></text> - <text + id="tspan5706">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -15545,9 +13323,7 @@ id="text5712"><tspan x="654.05402" y="699.15997" - id="tspan5710">₂</tspan></text> - </g> - <text + id="tspan5710">₂</tspan></text></g><text id="text5868-0" transform="translate(646,710)" fill="#000000" @@ -15558,12 +13334,9 @@ letter-spacing="0em"><tspan x="0.16406199" y="11.1602" - id="tspan5715">Hcys</tspan></text> - </g> - <g + id="tspan5715">Hcys</tspan></text></g><g id="Group 85" - transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"> - <text + transform="matrix(0.99609327,0,0,0.99818223,10.290067,14.005269)"><text id="text7967-0-3-6-2-7-4-34-0-4" transform="translate(823.03,724)" fill="#000000" @@ -15575,8 +13348,7 @@ letter-spacing="0em"><tspan x="0.09375" y="14.5469" - id="tspan5719">Gly</tspan></text> - <text + id="tspan5719">Gly</tspan></text><text id="text7967-0-3-65-5-3-5-8-9-7" fill="#000000" xml:space="preserve" @@ -15586,10 +13358,8 @@ letter-spacing="0em"><tspan x="713.18799" y="715.86401" - id="tspan5722">THF</tspan></text> - <g - id="text7967-0-3-65-1-2-4-9-6-3"> - <text + id="tspan5722">THF</tspan></text><g + id="text7967-0-3-65-1-2-4-9-6-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -15602,8 +13372,7 @@ id="tspan5725">H</tspan><tspan x="756.396" y="708.86401" - id="tspan5727">O</tspan></text> - <text + id="tspan5727">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -15613,9 +13382,7 @@ id="text5733"><tspan x="751.34601" y="708.86401" - 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stroke-width="2.20342" /> - <text + stroke-width="2.20342" /><text id="text7967-4" fill="#000000" xml:space="preserve" @@ -15969,8 +13681,7 @@ letter-spacing="0em"><tspan x="922" y="288.31201" - id="tspan1739">PRPP</tspan></text> - <text + id="tspan1739">PRPP</tspan></text><text id="text6997-5-1-8-3-7-4-9" fill="#000000" xml:space="preserve" @@ -15980,8 +13691,7 @@ letter-spacing="0em"><tspan x="988.49402" y="305.16" - id="tspan1742">Gly</tspan></text> - <text + id="tspan1742">Gly</tspan></text><text id="text6997-5-1-8-3-71-2-7-5" fill="#000000" xml:space="preserve" @@ -15991,8 +13701,7 @@ letter-spacing="0em"><tspan x="1041.47" y="305.16" - id="tspan1745">2 10fTHF</tspan></text> - <text + id="tspan1745">2 10fTHF</tspan></text><text id="text6997-5-1-8-3-7-7-9-1" fill="#000000" xml:space="preserve" @@ -16002,8 +13711,7 @@ letter-spacing="0em"><tspan x="959.42999" y="260.16" - id="tspan1748">2 THF</tspan></text> - <text + id="tspan1748">2 THF</tspan></text><text id="text6997-5-1-8-3-71-5-6-19" fill="#000000" xml:space="preserve" @@ -16013,8 +13721,7 @@ letter-spacing="0em"><tspan x="1066.16" y="261.16" - id="tspan1751">PPi</tspan></text> - <text + id="tspan1751">PPi</tspan></text><text id="text6997-5-1-8-3-71-5-7-36-5" fill="#000000" xml:space="preserve" @@ -16024,8 +13731,7 @@ letter-spacing="0em"><tspan x="1125.48" y="261.16" - id="tspan1754">4 ADP</tspan></text> - <text + id="tspan1754">4 ADP</tspan></text><text id="text6997-5-1-8-3-71-5-7-3-5-0" fill="#000000" xml:space="preserve" @@ -16035,8 +13741,7 @@ letter-spacing="0em"><tspan x="1033.49" y="260.16" - id="tspan1757">Fum</tspan></text> - <text + id="tspan1757">Fum</tspan></text><text id="text7967-5-8" fill="#000000" xml:space="preserve" @@ -16046,8 +13751,7 @@ letter-spacing="0em"><tspan x="957.14502" y="305.16" - id="tspan1760">2 Gln</tspan></text> - <text + id="tspan1760">2 Gln</tspan></text><text id="text6997-5-1-8-3-71-5-6-1-3" fill="#000000" xml:space="preserve" @@ -16057,8 +13761,7 @@ letter-spacing="0em"><tspan x="999.14502" y="260.16" - id="tspan1763">2 Glu</tspan></text> - <text + id="tspan1763">2 Glu</tspan></text><text id="text6997-5-1-8-3-7-4-9-6" fill="#000000" xml:space="preserve" @@ -16068,8 +13771,7 @@ letter-spacing="0em"><tspan x="1132.1" y="305.16" - 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id="tspan1783">CO</tspan></text> - <text + id="tspan1783">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16131,9 +13826,7 @@ id="text1789"><tspan x="1187.5" y="305.16" - id="tspan1787">₂</tspan></text> - </g> - <text + id="tspan1787">₂</tspan></text></g><text id="text6997-5-1-8-3-7-4-9-4" fill="#000000" xml:space="preserve" @@ -16143,8 +13836,7 @@ letter-spacing="0em"><tspan x="1012.16" y="377.16" - id="tspan1792">Asp</tspan></text> - <text + id="tspan1792">Asp</tspan></text><text id="text6997-5-1-8-3-71-2-7-5-2" fill="#000000" xml:space="preserve" @@ -16154,10 +13846,8 @@ letter-spacing="0em"><tspan x="928.09802" y="377.16" - id="tspan1795">2 ATP</tspan></text> - <g - id="text6997-5-1-8-3-7-7-9-1-8"> - <text + id="tspan1795">2 ATP</tspan></text><g + id="text6997-5-1-8-3-7-7-9-1-8"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16167,8 +13857,7 @@ id="text1800"><tspan x="965.48999" y="328.16" - id="tspan1798">QH</tspan></text> - <text + id="tspan1798">QH</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16178,9 +13867,7 @@ id="text1804"><tspan x="983.50201" y="328.16" - id="tspan1802">₂</tspan></text> - </g> - <text + id="tspan1802">₂</tspan></text></g><text id="text6997-5-1-8-3-71-5-7-36-5-3" fill="#000000" xml:space="preserve" @@ -16190,8 +13877,7 @@ letter-spacing="0em"><tspan x="1017.48" y="330.16" - id="tspan1807">2 ADP</tspan></text> - <text + id="tspan1807">2 ADP</tspan></text><text id="text7967-5-8-3" fill="#000000" xml:space="preserve" @@ -16201,8 +13887,7 @@ letter-spacing="0em"><tspan x="968.15399" y="377.16" - id="tspan1810">Gln</tspan></text> - <text + id="tspan1810">Gln</tspan></text><text id="text6997-5-1-8-3-71-5-6-1-3-1" fill="#000000" xml:space="preserve" @@ -16212,10 +13897,8 @@ letter-spacing="0em"><tspan x="993.15399" y="330.16" - id="tspan1813">Glu</tspan></text> - <g - id="text6997-5-1-8-3-7-4-9-6-3"> - <text + id="tspan1813">Glu</tspan></text><g + id="text6997-5-1-8-3-7-4-9-6-3"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16225,8 +13908,7 @@ id="text1818"><tspan x="1064.35" y="377.16" - id="tspan1816">HCO</tspan></text> - <text + id="tspan1816">HCO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16236,8 +13918,7 @@ id="text1822"><tspan x="1091.03" y="377.16" - id="tspan1820">₃</tspan></text> - <text + id="tspan1820">₃</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16247,9 +13928,7 @@ id="text1826"><tspan x="1095.25" y="377.16" - id="tspan1824">⁻</tspan></text> - </g> - <text + id="tspan1824">⁻</tspan></text></g><text id="text6997-5-1-8-3-7-4-9-2-2" fill="#000000" xml:space="preserve" @@ -16259,10 +13938,8 @@ letter-spacing="0em"><tspan x="995.33002" y="377.16" - id="tspan1829">Q</tspan></text> - <g - id="text6997-5-1-8-3-7-4-9-7-7"> - <text + id="tspan1829">Q</tspan></text><g + id="text6997-5-1-8-3-7-4-9-7-7"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16272,8 +13949,7 @@ id="text1834"><tspan x="1048.0601" y="377.16" - id="tspan1832">H</tspan></text> - <text + id="tspan1832">H</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16283,9 +13959,7 @@ id="text1838"><tspan x="1056.73" y="377.16" - id="tspan1836">⁺</tspan></text> - </g> - <text + id="tspan1836">⁺</tspan></text></g><text id="text6997-5-1-8-3-71-5-7-36-5-8-7" fill="#000000" xml:space="preserve" @@ -16295,10 +13969,8 @@ letter-spacing="0em"><tspan x="1083.84" y="331.27802" - id="tspan1841">PPi</tspan></text> - <g - id="text6997-5-1-8-3-71-5-7-36-5-8-9"> - <text + id="tspan1841">PPi</tspan></text><g + id="text6997-5-1-8-3-71-5-7-36-5-8-9"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16308,8 +13980,7 @@ id="text1846"><tspan x="1107.49" y="331.16" - id="tspan1844">CO</tspan></text> - <text + id="tspan1844">CO</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16319,9 +13990,7 @@ id="text1850"><tspan x="1125.5" y="331.16" - id="tspan1848">₂</tspan></text> - </g> - <text + id="tspan1848">₂</tspan></text></g><text id="text7967-0-3-6-2-78" fill="#000000" xml:space="preserve" @@ -16332,8 +14001,7 @@ letter-spacing="0em"><tspan x="1221.1" y="358.547" - id="tspan1853">UDP</tspan></text> - <text + id="tspan1853">UDP</tspan></text><text id="text7967-0-3-65-5-4" fill="#000000" xml:space="preserve" @@ -16343,8 +14011,7 @@ letter-spacing="0em"><tspan x="1171.27" y="336.16" - id="tspan1856">ATP</tspan></text> - <text + id="tspan1856">ATP</tspan></text><text id="text7967-0-3-65-1-8" fill="#000000" xml:space="preserve" @@ -16354,8 +14021,7 @@ letter-spacing="0em"><tspan x="1196.16" y="336.16" - id="tspan1859">ADP</tspan></text> - <text + id="tspan1859">ADP</tspan></text><text id="text7967-0-3-6-2-7-6" fill="#000000" xml:space="preserve" @@ -16366,10 +14032,8 @@ letter-spacing="0em"><tspan x="1212.21" y="406.547" - id="tspan1862">dUDP</tspan></text> - <g - id="text7967-0-3-65-1-3-5"> - <text + id="tspan1862">dUDP</tspan></text><g + id="text7967-0-3-65-1-3-5"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16382,8 +14046,7 @@ id="tspan1865">H</tspan><tspan x="1268.28" y="378.16" - id="tspan1867">O</tspan></text> - <text + id="tspan1867">O</tspan></text><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16393,19 +14056,15 @@ id="text1873"><tspan x="1264.05" y="378.16" - id="tspan1871">₂</tspan></text> - </g> - <path + id="tspan1871">₂</tspan></text></g><path id="B_UMPK" d="m 1189.5,344.52 -1.5,-3.5 -1.5,3.5 1.68,-0.617 z m -8,7 -6.5,2.355 6.51,2.296 -1.82,-2.296 z" stroke="#000000" - stroke-width="2.66667" /> - <path + stroke-width="2.66667" /><path id="F_UMPK" d="M 1202.51,344.933 C 1200.82,340 1200.82,340 1200.82,340 l -2.49,4.771 2.19,-1.132 z m 7.08,11.614 c 7.49,-2.521 7.49,-2.521 7.49,-2.521 l -7.66,-1.958 1.98,2.169 z" stroke="#000000" - stroke-width="2.66667" /> - <text + stroke-width="2.66667" /><text id="text7967-0-3-6-2-2-7" transform="rotate(-0.392185,57966.048,-190163.26)" fill="#2b0000" @@ -16418,8 +14077,7 @@ x="0.328125" y="14.5469" id="tspan1878" - style="fill:#000000">dUMP</tspan></text> - <text + style="fill:#000000">dUMP</tspan></text><text id="text7967-0-3-2-3" transform="rotate(0.808348,-28857.529,89246.093)" fill="#000000" @@ -16430,8 +14088,7 @@ letter-spacing="0em"><tspan x="0.160156" y="11.1602" - id="tspan1881">ADP</tspan></text> - <text + id="tspan1881">ADP</tspan></text><text id="text7967-0-3-1-6" transform="rotate(-0.829907,29385.126,-88505.134)" fill="#2b0000" @@ -16443,8 +14100,7 @@ x="0.27343801" y="11.1602" id="tspan1884" - style="fill:#000000">ATP</tspan></text> - <text + style="fill:#000000">ATP</tspan></text><text id="text7967-0-3-6-2-2-4" fill="#2b0000" xml:space="preserve" @@ -16456,8 +14112,7 @@ x="1458.22" y="405.547" id="tspan1887" - style="fill:#000000">dTMP</tspan></text> - <text + style="fill:#000000">dTMP</tspan></text><text id="text7967-0-3-2-4" transform="rotate(-0.416974,57898.223,-184605.41)" fill="#2b0000" @@ -16469,8 +14124,7 @@ x="0.30078101" y="11.1602" id="tspan1890" - style="fill:#000000">5,10meTHF</tspan></text> - <text + style="fill:#000000">5,10meTHF</tspan></text><text id="text7967-0-3-1-5" transform="rotate(0.26617,-88834.504,307398.67)" fill="#2b0000" @@ -16482,8 +14136,7 @@ x="0.160156" y="11.1602" id="tspan1893" - style="fill:#000000">DHF</tspan></text> - <text + style="fill:#000000">DHF</tspan></text><text id="text7967-0-3-6-2-0" fill="#000000" xml:space="preserve" @@ -16494,8 +14147,7 @@ letter-spacing="0em"><tspan x="1302.49" y="358.547" - id="tspan1896">UTP</tspan></text> - <text + id="tspan1896">UTP</tspan></text><text id="text7967-0-3-6-2-7-4" fill="#000000" xml:space="preserve" @@ -16506,8 +14158,7 @@ letter-spacing="0em"><tspan x="1440.49" y="358.547" - id="tspan1899">CTP</tspan></text> - <text + id="tspan1899">CTP</tspan></text><text id="text7967-0-3-65-1-3-2" fill="#2b0000" xml:space="preserve" @@ -16518,8 +14169,7 @@ x="1409.16" y="337.16" id="tspan1902" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text7967-0-3-65-1-3-2_2" fill="#2b0000" xml:space="preserve" @@ -16530,8 +14180,7 @@ x="1393.16" y="337.16" id="tspan1905" - style="fill:#000000">Pi</tspan></text> - <text + style="fill:#000000">Pi</tspan></text><text id="text7967-0-3-65-1-3-2-5" fill="#2b0000" xml:space="preserve" @@ -16542,11 +14191,9 @@ x="1336.27" y="337.16" id="tspan1908" - style="fill:#000000">ATP</tspan></text> - <g + style="fill:#000000">ATP</tspan></text><g id="text7967-0-3-65-1-3-2-5_2" - style="fill:#000000"> - <text + style="fill:#000000"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -16557,8 +14204,7 @@ x="1363.3199" y="337.16" id="tspan1911" - style="fill:#000000">NH</tspan></text> - <text + style="fill:#000000">NH</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -16569,9 +14215,7 @@ x="1380.67" y="337.16" id="tspan1915" - style="fill:#000000">₃</tspan></text> - </g> - <text + style="fill:#000000">₃</tspan></text></g><text id="text7967-0-3-6-2-7-4-3" fill="#2b0000" xml:space="preserve" @@ -16583,11 +14227,9 @@ x="1537.46" y="358.423" id="tspan1920" - style="fill:#000000">CDP</tspan></text> - <g + style="fill:#000000">CDP</tspan></text><g id="text7967-0-3-65-5-3-5-1" - style="fill:#000000"> - <text + style="fill:#000000"><text transform="rotate(0.250513,-73085.409,361085.02)" fill="#2b0000" xml:space="preserve" @@ -16603,8 +14245,7 @@ x="13.2779" y="11.1602" id="tspan1925" - style="fill:#000000">O</tspan></text> - <text + style="fill:#000000">O</tspan></text><text transform="rotate(0.250513,-73085.409,361085.02)" fill="#2b0000" xml:space="preserve" @@ -16616,9 +14257,7 @@ x="9.0541096" y="11.1602" id="tspan1929" - style="fill:#000000">₂</tspan></text> - </g> - <text + style="fill:#000000">₂</tspan></text></g><text id="text7967-0-3-6-2-7-4-3-9-7" fill="#2b0000" xml:space="preserve" @@ -16630,8 +14269,7 @@ x="1605.21" y="357.349" id="tspan1934" - style="fill:#000000">dCDP</tspan></text> - <text + style="fill:#000000">dCDP</tspan></text><text id="text7967-0-3-65-5-3-5-8" transform="rotate(0.250513,-72361.769,378237.03)" fill="#2b0000" @@ -16643,8 +14281,7 @@ x="0.27343801" y="11.1602" id="tspan1937" - style="fill:#000000">ATP</tspan></text> - <text + style="fill:#000000">ATP</tspan></text><text id="text7967-0-3-65-1-2-4-9" transform="rotate(-0.639009,29556.536,-150383.31)" fill="#2b0000" @@ -16656,46 +14293,39 @@ x="0.160156" y="11.1602" id="tspan1940" - style="fill:#000000">ADP</tspan></text> - <path + style="fill:#000000">ADP</tspan></text><path id="F_NDPK7" d="m 1684.65,340.48 c -1.45,-7.288 -1.45,-7.288 -1.45,-7.288 l -1.86,7.16 1.71,-1.742 z m 5.79,15.4 c 7.48,-2.544 7.48,-2.544 7.48,-2.544 l -7.66,-1.935 1.98,2.163 z" fill="#2b0000" stroke="#000000" stroke-width="2.23952" - style="fill:none" /> - <path + style="fill:none" /><path d="m 1670.46,337.15 c -2.87,10.073 3.56,16.573 3.56,16.573 m 3.45,-0.202 c 5.59,-1.26 5.2,-14.749 5.2,-14.749 m -24.28,14.67 33.74,0.294" stroke="#000000" stroke-width="2.23449" id="R_NDPK7" - inkscape:label="R_NDPK7" /> - <path + inkscape:label="R_NDPK7" /><path id="B_NDPK7" d="m 1671.3,341.229 c -1.44,-7.289 -1.44,-7.289 -1.44,-7.289 l -1.87,7.16 1.71,-1.742 z m -10.92,10.221 c -7.52,2.444 -7.52,2.444 -7.52,2.444 l 7.64,2.036 -1.96,-2.189 z" fill="#2b0000" stroke="#000000" stroke-width="2.23952" - style="fill:none" /> - <path + style="fill:none" /><path id="R_UMPK" d="m 1177,353.831 33.95,0.192 m -23.09,-10.669 c -1.46,6.58 4.5,10.071 4.5,10.071 m 5.17,0.629 c 4.5,-1.356 2.82,-10.457 2.82,-10.457" stroke="#000000" - stroke-width="1.95125" /> - <path + stroke-width="1.95125" /><path d="m 1269.09,401.009 24.35,0.11 m -18.26,9.747 c -2.83,-5.901 3.18,-9.765 3.18,-9.765 m 3.28,-0.044 c 5.26,0.758 5.05,9.321 5.05,9.321" stroke="#000000" stroke-width="1.95125" id="R_URIDK2r" - inkscape:label="R_URIDK2r" /> - <path + inkscape:label="R_URIDK2r" /><path id="B_URIDK2r" fill-rule="evenodd" clip-rule="evenodd" d="m 1276.45,409.448 c -1.83,5.701 -1.83,5.701 -1.83,5.701 l -1.28,-5.879 1.49,1.536 z m -7,-6.152 c -7.55,-2.358 -7.55,-2.358 -7.55,-2.358 l 7.62,-2.124 -1.93,2.212 z" stroke="#000000" - stroke-width="1.95125" /> - <path + stroke-width="1.95125" /><path id="F_URIDK2r" fill-rule="evenodd" clip-rule="evenodd" @@ -16703,14 +14333,12 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path d="m 1421,353 c 6.37,-0.976 0.5,-9 0.5,-9 m -51,0 c -5,5 3.5,9 3.5,9 m -35,0 c 0,0 4.55,0 12.5,0 m 79.5,0 c 0,0 -14.58,0 -29.5,0 m 0,0 c 7.34,-4.179 0,-9.5 0,-9.5 m 0,9.5 c -12.4,0 -38.55,0 -50,0 m 0,0 c 0,0 -6.39,-2.695 -2.72,-9" stroke="#000000" stroke-width="1.82832" id="R_CTPS1" - inkscape:label="R_CTPS1" /> - <text + inkscape:label="R_CTPS1" /><text id="text7967-0-3-8" fill="#000000" xml:space="preserve" @@ -16721,8 +14349,7 @@ letter-spacing="0em"><tspan x="1134.22" y="358.86801" - id="tspan1963">UMP</tspan></text> - <text + id="tspan1963">UMP</tspan></text><text id="text7967-0-3" fill="#2b0000" xml:space="preserve" @@ -16734,8 +14361,7 @@ x="1507.27" y="286.547" id="tspan1966" - style="fill:#000000">GMP</tspan></text> - <text + style="fill:#000000">GMP</tspan></text><text id="text7967-0-3-6-2" fill="#2b0000" xml:space="preserve" @@ -16747,8 +14373,7 @@ x="1508.16" y="215.547" id="tspan1969" - style="fill:#000000">GDP</tspan></text> - <text + style="fill:#000000">GDP</tspan></text><text id="text7967-0-3-6-2-7" fill="#2b0000" xml:space="preserve" @@ -16760,10 +14385,8 @@ x="1503.27" y="168.547" id="tspan1972" - style="fill:#000000">dGDP</tspan></text> - <g - id="text7967-0-3-65-1-3"> - <text + style="fill:#000000">dGDP</tspan></text><g + id="text7967-0-3-65-1-3"><text fill="#2b0000" xml:space="preserve" style="white-space:pre" @@ -16773,8 +14396,7 @@ id="text1977"><tspan x="1493.83" y="190.16" - id="tspan1975">2</tspan></text> - <text + id="tspan1975">2</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre" @@ -16787,9 +14409,7 @@ id="tspan1979">H</tspan><tspan x="1500.51" y="190.16" - id="tspan1981">O</tspan></text> - </g> - <text + id="tspan1981">O</tspan></text></g><text id="text7967-0-3-0" fill="#000000" xml:space="preserve" @@ -16800,8 +14420,7 @@ letter-spacing="0em"><tspan x="1193.22" y="208.547" - id="tspan1986">AMP</tspan></text> - <text + id="tspan1986">AMP</tspan></text><text id="text7967-0-3-2-0" fill="#000000" xml:space="preserve" @@ -16811,8 +14430,7 @@ letter-spacing="0em"><tspan x="1166.16" y="166.16" - id="tspan1989">ADP</tspan></text> - <text + id="tspan1989">ADP</tspan></text><text id="text7967-0-3-9" fill="#000000" xml:space="preserve" @@ -16823,8 +14441,7 @@ letter-spacing="0em"><tspan x="1194.1" y="138.547" - id="tspan1992">ADP</tspan></text> - <text + id="tspan1992">ADP</tspan></text><text id="text7967-0-3-7" fill="#000000" xml:space="preserve" @@ -16834,10 +14451,8 @@ letter-spacing="0em"><tspan x="1166.27" y="180.16" - id="tspan1995">ATP</tspan></text> - <g - id="text7967-0-3-2-2"> - <text + id="tspan1995">ATP</tspan></text><g + id="text7967-0-3-2-2"><text fill="#000000" xml:space="preserve" style="white-space:pre" @@ -16850,8 +14465,7 @@ id="tspan1998">H</tspan><tspan x="1244.28" y="161.644" - 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stroke-width="2.23952" /> - <text + stroke-width="2.23952" /><text id="text5529" fill="#2b0000" xml:space="preserve" @@ -16933,8 +14536,7 @@ x="1576.16" y="141.16" id="tspan2020" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text5537" fill="#2b0000" xml:space="preserve" @@ -16945,8 +14547,7 @@ x="1551.27" y="141.16" id="tspan2023" - style="fill:#000000">ATP</tspan></text> - <text + style="fill:#000000">ATP</tspan></text><text id="text5543" fill="#000000" xml:space="preserve" @@ -16957,8 +14558,7 @@ letter-spacing="0em"><tspan x="1606.16" y="168.547" - id="tspan2026">dGTP</tspan></text> - <text + id="tspan2026">dGTP</tspan></text><text id="text5547" fill="#2b0000" xml:space="preserve" @@ -16969,8 +14569,7 @@ x="1337.16" y="164.16" id="tspan2029" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text5555" fill="#2b0000" xml:space="preserve" @@ -16981,14 +14580,12 @@ x="1311.27" y="164.16" id="tspan2032" - style="fill:#000000">ATP</tspan></text> - <path + style="fill:#000000">ATP</tspan></text><path d="m 1347.03,131.741 -23.95,0.27 m 6.33,13.207 c -2.32,-8.385 3.86,-13.457 3.86,-13.457 m 3.22,0.114 c 5.1,1.34 4.24,13.279 4.24,13.279" stroke="#000000" stroke-width="1.95125" id="R_NDPK8" - inkscape:label="R_NDPK8" /> - <path + inkscape:label="R_NDPK8" /><path id="B_NDPK8" fill-rule="evenodd" clip-rule="evenodd" @@ -16996,8 +14593,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_NDPK8" fill-rule="evenodd" clip-rule="evenodd" @@ -17005,8 +14601,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text5562" fill="#000000" xml:space="preserve" @@ -17017,8 +14612,7 @@ letter-spacing="0em"><tspan x="1358.2" y="137.547" - id="tspan2042">dATP</tspan></text> - <text + id="tspan2042">dATP</tspan></text><text id="text5590" fill="#000000" xml:space="preserve" @@ -17029,8 +14623,7 @@ letter-spacing="0em"><tspan x="1702.1" y="357.547" - 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id="tspan2059">2 Pi</tspan></text> - <path + id="tspan2059">2 Pi</tspan></text><path id="F_OMPDC" d="m 1111.62,340.747 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.6,-1.841 z m -20.26,0 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.61,-1.841 z m -24.93,0 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.61,-1.841 z m -37.4,0 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.43,7.259 1.6,-1.841 z M 1121,357 l 8,-3.5 -8,-3.5 2,3.5 z M 980.316,339.189 C 978.436,332 978.436,332 978.436,332 l -1.436,7.258 1.603,-1.84 z m 26.904,1.558 c -1.88,-7.189 -1.88,-7.189 -1.88,-7.189 l -1.44,7.259 1.61,-1.841 z" stroke="#000000" - stroke-width="2.23952" /> - <path + stroke-width="2.23952" /><path d="m 1364.19,400.415 80.81,-0.108 m -74.72,9.809 c -2.83,-5.901 3.18,-9.765 3.18,-9.765 m 57.54,-0.026 c 8,1.175 9.5,9.175 9.5,9.175" stroke="#000000" stroke-width="1.95125" id="R_TMDS" - inkscape:label="R_TMDS" /> - <path + inkscape:label="R_TMDS" /><path id="B_TMDS" fill-rule="evenodd" clip-rule="evenodd" @@ -17106,8 +14691,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_TMDS" fill-rule="evenodd" clip-rule="evenodd" @@ -17115,8 +14699,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4125" transform="rotate(0.808348,-28686.836,108559.65)" fill="#2b0000" @@ -17128,8 +14711,7 @@ x="0.160156" y="11.1602" id="tspan2070" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text4129" transform="rotate(-0.829907,29494.126,-103555.33)" fill="#2b0000" @@ -17141,14 +14723,12 @@ x="0.27343801" y="11.1602" id="tspan2073" - style="fill:#000000">ATP</tspan></text> - <path + style="fill:#000000">ATP</tspan></text><path d="m 1516.45,400.415 24.35,0.11 m -18.27,9.747 c -2.82,-5.901 3.19,-9.765 3.19,-9.765 m 3.28,-0.045 c 5.26,0.759 5.04,9.322 5.04,9.322" stroke="#000000" stroke-width="1.95125" id="R_DTMPK" - inkscape:label="R_DTMPK" /> - <path + inkscape:label="R_DTMPK" /><path id="B_DTMPK" fill-rule="evenodd" clip-rule="evenodd" @@ -17156,8 +14736,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_DTMPK" fill-rule="evenodd" clip-rule="evenodd" @@ -17165,8 +14744,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4162" transform="rotate(0.808348,-22394.837,91002.335)" fill="#2b0000" @@ -17178,8 +14756,7 @@ x="0.160156" y="11.1602" id="tspan2083" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text4166" transform="rotate(-0.829907,23131.44,-86617.272)" fill="#000000" @@ -17190,21 +14767,18 @@ letter-spacing="0em"><tspan x="0.27343801" y="11.1602" - id="tspan2086">ATP</tspan></text> - <path + id="tspan2086">ATP</tspan></text><path d="m 1268.26,352.978 24.35,-0.111 m -18.27,-9.746 c -2.82,5.9 3.19,9.764 3.19,9.764 m 3.28,0.045 c 5.26,-0.759 5.04,-9.322 5.04,-9.322" stroke="#000000" stroke-width="1.95125" id="R_NDPK2" - inkscape:label="R_NDPK2" /> - <path + inkscape:label="R_NDPK2" /><path id="B_NDPK2" fill-rule="evenodd" clip-rule="evenodd" d="m 1275.62,344.538 c -1.83,-5.7 -1.83,-5.7 -1.83,-5.7 l -1.28,5.879 1.48,-1.537 z m -7.01,6.153 c -7.54,2.358 -7.54,2.358 -7.54,2.358 l 7.61,2.123 -1.93,-2.211 z" stroke="#000000" - stroke-width="1.95125" /> - <path + stroke-width="1.95125" /><path id="F_NDPK2" fill-rule="evenodd" clip-rule="evenodd" @@ -17212,8 +14786,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4194" transform="rotate(0.808348,-22319.07,105490.88)" fill="#2b0000" @@ -17225,8 +14798,7 @@ x="0.160156" y="11.1602" id="tspan2096" - style="fill:#000000">ADP</tspan></text> - <text + style="fill:#000000">ADP</tspan></text><text id="text4198" transform="rotate(-0.829907,23236.989,-104251.01)" fill="#2b0000" @@ -17238,14 +14810,12 @@ x="0.27343801" y="11.1602" id="tspan2099" - style="fill:#000000">ATP</tspan></text> - <path + style="fill:#000000">ATP</tspan></text><path d="m 1485.19,352.976 41.17,-0.068 m -25.74,-9.768 c -2.82,5.901 3.19,9.765 3.19,9.765 m 6.39,0.044 c 5.27,-0.758 5.05,-9.321 5.05,-9.321" stroke="#000000" stroke-width="2.00453" id="R_NDPK3" - inkscape:label="R_NDPK3" /> - <path + inkscape:label="R_NDPK3" /><path id="B_NDPK3" fill-rule="evenodd" clip-rule="evenodd" @@ -17253,8 +14823,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path id="F_NDPK3" fill-rule="evenodd" clip-rule="evenodd" @@ -17262,14 +14831,12 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <path + style="fill:none" /><path d="m 1574,353.5 20,-0.095 m -12,0.057 c 7,-1.462 3.5,-9.462 3.5,-9.462" stroke="#000000" stroke-width="1.97845" id="R_RNDR3" - inkscape:label="R_RNDR3" /> - <path + inkscape:label="R_RNDR3" /><path id="F_RNDR3" fill-rule="evenodd" clip-rule="evenodd" @@ -17277,8 +14844,7 @@ fill="#2b0000" stroke="#000000" stroke-width="1.95125" - style="fill:none" /> - <text + style="fill:none" /><text id="text4284" fill="#000000" xml:space="preserve" @@ -17288,8 +14854,7 @@ letter-spacing="0em"><tspan x="1174.16" y="262.16" - id="tspan2115">GTP</tspan></text> - <text + id="tspan2115">GTP</tspan></text><text id="text4288" fill="#000000" xml:space="preserve" @@ -17299,8 +14864,7 @@ letter-spacing="0em"><tspan x="1180.16" y="243.16" - id="tspan2118">Asp</tspan></text> - <text + id="tspan2118">Asp</tspan></text><text id="text4296" fill="#000000" xml:space="preserve" @@ -17310,8 +14874,7 @@ letter-spacing="0em"><tspan x="1228.49" y="244.16" - id="tspan2121">GDP</tspan></text> - <text + id="tspan2121">GDP</tspan></text><text id="text4300" fill="#000000" xml:space="preserve" @@ -17321,8 +14884,7 @@ letter-spacing="0em"><tspan x="1228.16" y="259.16" - id="tspan2124">Pi</tspan></text> - <text + id="tspan2124">Pi</tspan></text><text id="text4304" fill="#000000" xml:space="preserve" @@ -17332,10 +14894,8 @@ letter-spacing="0em"><tspan x="1228.49" y="229.16" - id="tspan2127">Fum</tspan></text> - <g - id="text4331"> - <text + id="tspan2127">Fum</tspan></text><g + id="text4331"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17346,8 +14906,7 @@ x="1244.22" y="265.16" id="tspan2130" - style="fill:#000000">NAD</tspan></text> - <text + style="fill:#000000">NAD</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17358,11 +14917,8 @@ x="1269.5699" y="265.16" id="tspan2134" - style="fill:#000000">⁺</tspan></text> - </g> - <g - id="text4339"> - <text + style="fill:#000000">⁺</tspan></text></g><g + id="text4339"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17377,8 +14933,7 @@ x="1293.28" y="265.16" id="tspan2141" - style="fill:#000000">O</tspan></text> - <text + style="fill:#000000">O</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17390,9 +14945,7 @@ x="1288.046" y="265.16" id="tspan2145" - style="fill:#000000">₂</tspan></text> - </g> - <text + style="fill:#000000">₂</tspan></text></g><text id="text4343" fill="#2b0000" xml:space="preserve" @@ -17403,10 +14956,8 @@ x="1311.27" y="265.16" id="tspan2150" - style="fill:#000000">ATP</tspan></text> - <g - id="text4347"> - <text + style="fill:#000000">ATP</tspan></text><g + id="text4347"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17417,8 +14968,7 @@ x="1343.3199" y="265.16" id="tspan2153" - style="fill:#000000">NH</tspan></text> - <text + style="fill:#000000">NH</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17429,9 +14979,7 @@ x="1360.67" y="265.16" id="tspan2157" - style="fill:#000000">₃</tspan></text> - </g> - <text + style="fill:#000000">₃</tspan></text></g><text id="text4371" fill="#2b0000" xml:space="preserve" @@ -17442,10 +14990,8 @@ x="1476.49" y="262.16" id="tspan2162" - style="fill:#000000">NADH</tspan></text> - <g - id="text4385"> - <text + style="fill:#000000">NADH</tspan></text><g + id="text4385"><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17456,8 +15002,7 @@ x="1412.0601" y="262.16" id="tspan2165" - style="fill:#000000">H</tspan></text> - <text + style="fill:#000000">H</tspan></text><text fill="#2b0000" xml:space="preserve" style="white-space:pre;fill:#000000" @@ -17468,9 +15013,7 @@ x="1420.73" y="262.16" id="tspan2169" - style="fill:#000000">⁺</tspan></text> - </g> - <text + style="fill:#000000">⁺</tspan></text></g><text id="text4389" fill="#2b0000" xml:space="preserve" @@ -17481,8 +15024,7 @@ x="1439.5" y="262.16" id="tspan2174" - 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--- a/flux_to_map.xml Tue May 20 14:50:20 2025 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,257 +0,0 @@ -<tool id="FluxToMap" name="Metabolic Flux Enrichment Analysis" version="2.0.0"> - <macros> - <import>marea_macros.xml</import> - </macros> - - <requirements> - <requirement type="package" version="1.24.4">numpy</requirement> - <requirement type="package" version="2.0.3">pandas</requirement> - <requirement type="package" version="0.13.0">seaborn</requirement> - <requirement type="package" version="1.10.1">scipy</requirement> - <requirement type="package" version="1.5.1">svglib</requirement> - <requirement type="package" version="2.2.3">pyvips</requirement> - <requirement type="package" version="2.7.1">cairosvg</requirement> - <requirement type="package" version="0.29.0">cobra</requirement> - <requirement type="package" version="5.2.2">lxml</requirement> - </requirements> - - <command detect_errors="exit_code"> - <![CDATA[ - python $__tool_directory__/flux_to_map.py - - --tool_dir $__tool_directory__ - --option $cond.type_selector - --out_log $log - --color_map $color_map - - #if $cond.type_selector == 'datasets': - - --input_datas_fluxes - #for $data in $cond.input_datasets_fluxes: - ${data.input_fluxes} - #end for - - --names_fluxes - #for $data in $cond.input_datasets_fluxes: - ${data.input_name_fluxes} - #end for - - #elif $cond.type_selector == 'dataset_class': - - --input_data_fluxes $input_data_fluxes - --input_class_fluxes $input_class_fluxes - - #end if - - --comparison ${comparis.comparison} - #if $comparis.comparison == 'onevsmany' - --control '${comparis.controlgroup}' - #end if - - --choice_map '${cond_choice_map.choice_map}' - #if $cond_choice_map.choice_map == 'Custom': - --custom_map ${cond_choice_map.custom_map} - #end if - - #if $advanced.choice == 'true': - --test ${advanced.test} - --pValue ${advanced.pValue} - --adjusted ${advanced.adjusted} - --fChange ${advanced.fChange} - --generate_svg ${advanced.generateSvg} - --generate_pdf ${advanced.generatePdf} - #else - --test 'ks' - --pValue 0.05 - --adjusted false - --fChange 1.2 - --generate_svg false - --generate_pdf true - #end if - ]]> - </command> - - <inputs> - - <conditional name="cond"> - <param name="type_selector" argument="--option" type="select" label="Input format:"> - <option value="datasets" selected="true">Fluxes of group 1 + Fluxes of group 2 + ... + Fluxes of group N</option> - <option value="dataset_class">All fluxes + sample group specification</option> - </param> - - <when value="datasets"> - <repeat name="input_datasets_fluxes" title="Fluxes dataset" min="2"> - <param name="input_fluxes" argument="--input_datas_fluxes" type="data" format="tabular, csv, tsv" label="add dataset" /> - <param name="input_name_fluxes" argument="--names_fluxes" type="text" label="Dataset's name:" value="Dataset" help="Default: Dataset" /> - </repeat> - </when> - - <when value="dataset_class"> - <param name="input_data_fluxes" argument="--input_data_fluxes" type="data" format="tabular, csv, tsv" label="All fluxes" /> - <param name="input_class_fluxes" argument="--input_class_fluxes" type="data" format="tabular, csv, tsv" label="Sample group specification" /> - </when> - </conditional> - - <conditional name="comparis"> - <param name="comparison" argument="--comparison" type="select" label="Groups comparison:"> - <option value="manyvsmany" selected="true">One vs One</option> - <option value="onevsrest">One vs All</option> - <option value="onevsmany">One vs Control</option> - </param> - <when value="onevsmany"> - <param name="controlgroup" argument="--controlgroup" type="text" label="Control group label:" value="0" help="Name of group label to be compared to others"/> - </when> - </conditional> - - <conditional name="cond_choice_map"> - <param name="choice_map" argument="--choice_map" type="select" label="Choose metabolic map:"> - <option value="ENGRO2" selected="true">ENGRO2</option> - <option value="HMRcore" >HMRcore</option> - <option value="Custom">Custom</option> - </param> - - <when value="Custom"> - <param name="custom_map" argument="--custom_map" type="data" format="xml, svg" label="custom-map.svg"/> - </when> - </conditional> - - <param name="color_map" argument="--color_map" type="select" label="Color map:"> - <option value="viridis" selected="true">Viridis</option> - <option value="jet">Jet</option> - </param> - - <conditional name="advanced"> - <param name="choice" type="boolean" checked="false" label="Use advanced options?" help="Use this options to choose custom parameters for evaluation: statistical test, pValue, Fold-Change threshold, how to solve (A and NaN) and specify output maps."> - <option value="true" selected="true">No</option> - <option value="false">Yes</option> - </param> - - <when value="true"> - <param name="test" argument="--test" type="select" label="Statistical test to use" help="Select the statistical test to use for the analysis based on your data and the amount of replicates. Paired T-test and Wilcoxon need the same number of replicates in each group."> - <option value="ks" selected="true">Kolmogorov-Smirnov</option> - <option value="ttest_p">T-test (paired)</option> - <option value="ttest_ind">T-test (unpaired)</option> - <option value="wilcoxon">Wilcoxon</option> - <option value="mw">Mann-Whitney</option> - </param> - <param name="pValue" argument="--pValue" type="float" size="20" value="0.05" max="1" min="0" label="P-value threshold:" help="min value 0" /> - <param name="adjusted" argument="--adjusted" type="boolean" checked="false" label="Use adjusted p-values" help="Should the program adjust the P-values based on the FDR (Benjamini-Hochberg) correction?" /> - <param name="fChange" argument="--fChange" type="float" size="20" value="1.2" min="1" label="Fold-Change threshold:" help="min value 1" /> - <param name="generateSvg" argument="--generateSvg" type="boolean" checked="false" label="Generate SVG map" help="should the program generate an editable svg map of the processes?" /> - <param name="generatePdf" argument="--generatePdf" type="boolean" checked="true" label="Generate PDF map" help="should the program return a non editable (but displayble) pdf map of the processes?" /> - </when> - </conditional> - </inputs> - - <outputs> - <data format="txt" name="log" label="FluxToMap - Log" /> - <collection name="results" type="list" label="FluxToMap - Results"> - <discover_datasets pattern="__name_and_ext__" directory="result"/> - </collection> - </outputs> - - <help> - <![CDATA[ - -What it does -------------- - -This tool analyzes and visualizes differences in reactions fluxes of groups of samples, returned by the Flux Simulation tool, of groups of samples. - -Accepted files are (Files must have different names): - - option 1) two or more fluxes datasets, each referring to samples in a given group. The user can specify a label for each group; - - option 2) one fluxes dataset and one group-file specifying the group each sample belongs to (e.g. the accepted group file is thought to be the one returned by the Clustering tool). - -Optional files: - - custom svg map. Graphical elements must have the same IDs of reactions. See HmrCore svg map for an example. - -The tool generates: - - A tab-separated file: reporting fold-change and p-values of fluxes between a pair of conditions/classes; - - A metabolic map file (downloadable as .svg and .png): visualizing up- and down-regulated reactions between a pair of conditions/classes; - - Two metabolic maps to visualize the mean and median fluxes normalized amongst all classes. The associated color map is also generated (absolute ranges); - - A log file (.txt). - -Output options: - - To calculate P-Values and Fold-Changes and to enrich maps, comparisons are performed for each possible pair of groups (default option ‘One vs One’). - -Alternative options are: - - comparison of each group vs. the rest of samples (option ‘One vs Rest’) - - comparison of each group vs. a control group (option ‘One vs Control). If this option is selected the user must indicate the control group label. - -Output files will be named as classA_vs_classB. Reactions will conventionally be reported as up-regulated (down-regulated) if they are significantly more (less) active in class having label "classA". - -Example input -------------- - -"Fluxes of group 1 + Fluxes of group 2 + ... + Fluxes of group N" option: - -Fluxes Dataset 1: - -+------------+----------------+----------------+----------------+ -| Reaction ID| TCGAA62670 | TCGAA62671 | TCGAA62672 | -+============+================+================+================+ -| r1642 | 0.523167 | 0.371355 | 0.925661 | -+------------+----------------+----------------+----------------+ -| r1643 | 0.568765 | 0.765567 | 0.456789 | -+------------+----------------+----------------+----------------+ -| r1640 | 0.876545 | 0.768933 | 0.987654 | -+------------+----------------+----------------+----------------+ -| r1641 | 0.456788 | 0.876543 | 0.876542 | -+------------+----------------+----------------+----------------+ -| r1646 | 0.876543 | 0.786543 | 0.897654 | -+------------+----------------+----------------+----------------+ - -Fluxes Dataset 2: - -+------------+----------------+----------------+----------------+ -| Reaction ID| TCGAA62670 | TCGAA62671 | TCGAA62672 | -+============+================+================+================+ -| r1642 | 0.523167 | 0.371355 | 0.925661 | -+------------+----------------+----------------+----------------+ -| r1643 | 0.568765 | 0.765567 | 0.456789 | -+------------+----------------+----------------+----------------+ -| r1640 | 0.876545 | 0.768933 | 0.987654 | -+------------+----------------+----------------+----------------+ -| r1641 | 0.456788 | 0.876543 | 0.876542 | -+------------+----------------+----------------+----------------+ -| r1646 | 0.876543 | 0.786543 | 0.897654 | -+------------+----------------+----------------+----------------+ - -"Fluxes of all samples + sample group specification" option: - -Fluxes Dataset: - -+------------+----------------+----------------+----------------+ -| Reaction ID| TCGAA62670 | TCGAA62671 | TCGAA62672 | -+============+================+================+================+ -| r1642 | 0.523167 | 0.371355 | 0.925661 | -+------------+----------------+----------------+----------------+ -| r1643 | 0.568765 | 0.765567 | 0.456789 | -+------------+----------------+----------------+----------------+ -| r1640 | 0.876545 | 0.768933 | 0.987654 | -+------------+----------------+----------------+----------------+ -| r1641 | 0.456788 | 0.876543 | 0.876542 | -+------------+----------------+----------------+----------------+ -| r1646 | 0.876543 | 0.786543 | 0.897654 | -+------------+----------------+----------------+----------------+ - -Group-file - -+---------------+-----------+ -| Patient ID | Class | -+===============+===========+ -| TCGAAA3529 | MSI | -+---------------+-----------+ -| TCGAA62671 | MSS | -+---------------+-----------+ -| TCGAA62672 | MSI | -+---------------+-----------+ - - -**TIP**: If your dataset is not split into classes, use MaREA cluster analysis. - - -]]> - </help> - <expand macro="citations" /> -</tool> \ No newline at end of file