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1 #Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut
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2 gyrA gyrA 83 AGT S R,I,N,L,Y Nalidixic acid, Ciprofloxacin 12373497,9527801 Target modification Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
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3 gyrA gyrA 87 GAG E K,G,L Nalidixic acid, Ciprofloxacin 12373497,12373497,12373497 Target modification Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
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4 gyrA gyrA 97 AGT S N Nalidixic acid, Ciprofloxacin 10508034 Target modification Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
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5 parC parC 80 AGC S R,I Nalidixic acid, Ciprofloxacin 12373497,12373497 Target modification
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6 parC parC 84 GAA E A,K,T Nalidixic acid, Ciprofloxacin 12373497,9527801 Target modification
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7 pbp5 pbp5 24 GTA V A Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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8 pbp5 pbp5 27 AGT S G Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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9 pbp5 pbp5 34 CGG R Q Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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10 pbp5 pbp5 66 GGA G E Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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11 pbp5 pbp5 68 GCA A T Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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12 pbp5 pbp5 85 GAA E D Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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13 pbp5 pbp5 100 GAG E Q Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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14 pbp5 pbp5 144 AAA K Q Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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15 pbp5 pbp5 172 ACA T A Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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16 pbp5 pbp5 177 TTA L I Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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17 pbp5 pbp5 204 GAC D G Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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18 pbp5 pbp5 216 GCA A S Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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19 pbp5 pbp5 324 ACA T A Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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20 pbp5 pbp5 485 ATG M A,T Ampicillin 25182648,25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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21 pbp5 pbp5 496 AAT N K Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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22 pbp5 pbp5 499 GCA A T,I Ampicillin 25182648,25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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23 pbp5 pbp5 525 GAG E D Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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24 pbp5 pbp5 586 GTA V L Ampicillin 25182648 Target modification Not essential for resistance phenotype
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25 pbp5 pbp5 629 GAA E V Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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26 pbp5 pbp5 667 CCC P S Ampicillin 25182648 Target modification The nineteen pbp5 mutations must be present simultaneously for resistance phenotype
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27 # Indels
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28 pbp5 pbp5 466 - ins S,D Ampicillin 25182648,25182648 Target modification Not essential for resistance phenotype
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