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"planemo upload commit fe7295ad48151648562b06d5b075a68d77747326"
| author | guerler |
|---|---|
| date | Thu, 08 Apr 2021 18:20:04 +0000 |
| parents | ad4b7db26523 |
| children |
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Query NP_000836.2 Match_columns 908 No_of_seqs 3628 out of 54127 Neff 10.7604 Searched_HMMs 7012 Date Sun Jul 26 14:02:06 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000836.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000836.2.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 6N4X_A Metabotropic glutamate 100.0 2.5E-77 1.8E-81 724.0 0.0 801 35-855 30-845 (877) 2 6N52_B Metabotropic glutamate 100.0 1.2E-76 8.4E-81 718.1 0.0 803 34-856 29-846 (871) 3 6N51_B Metabotropic glutamate 100.0 6.7E-76 4.8E-80 706.5 0.0 786 37-842 4-804 (804) 4 6W2Y_A Gamma-aminobutyric acid 100.0 3.8E-66 2.8E-70 620.7 0.0 685 36-853 22-734 (829) 5 6W2X_B Gamma-aminobutyric acid 100.0 8.6E-65 6.2E-69 611.4 0.0 678 36-852 13-725 (908) 6 6UO8_A Gamma-aminobutyric acid 100.0 9.3E-65 6.7E-69 605.5 0.0 682 42-856 3-712 (762) 7 6UO8_B Gamma-aminobutyric acid 100.0 2.2E-64 1.6E-68 602.9 0.0 675 39-852 9-718 (779) 8 7C7Q_A Gamma-aminobutyric acid 100.0 3.4E-62 2.5E-66 592.4 0.0 685 40-855 166-876 (879) 9 2E4U_A Metabotropic glutamate 100.0 1.2E-43 8.6E-48 406.8 0.0 535 40-584 9-553 (555) 10 2E4X_B Metabotropic glutamate 100.0 1.2E-43 8.6E-48 406.8 0.0 535 40-584 9-553 (555) 11 6N50_A Metabotropic glutamate 100.0 4.1E-43 3E-47 405.6 0.0 536 36-576 42-589 (596) 12 6N4Y_C Metabotropic glutamate 100.0 4.4E-43 3.2E-47 405.3 0.0 536 36-576 42-589 (596) 13 5K5S_B Extracellular calcium-s 100.0 1.3E-42 9.6E-47 402.9 0.0 534 39-580 25-609 (615) 14 5KZQ_A Metabotropic glutamate 100.0 1.7E-42 1.2E-46 398.2 0.0 529 38-580 24-564 (570) 15 5K5T_A Extracellular calcium-s 100.0 2.4E-42 1.8E-46 400.9 0.0 534 39-580 25-609 (615) 16 6FFH_A Metabotropic glutamate 100.0 9.6E-38 6.9E-42 309.0 0.0 266 573-852 4-431 (444) 17 6FFI_A Metabotropic glutamate 100.0 9.6E-38 6.9E-42 309.0 0.0 266 573-852 4-431 (444) 18 4OR2_B Chimera of Soluble cyto 100.0 1.8E-37 1.3E-41 330.2 0.0 271 570-854 108-380 (389) 19 6BT5_B Metabotropic glutamate 99.9 2.3E-27 1.7E-31 265.1 0.0 468 40-507 4-471 (479) 20 6BSZ_A Metabotropic glutamate 99.9 3.3E-27 2.4E-31 263.8 0.0 468 40-507 4-471 (479) 21 3KS9_B Metabotropic glutamate 99.8 1.4E-26 1E-30 259.8 0.0 465 37-506 9-489 (496) 22 4XAR_A Metabotropic glutamate 99.8 1.6E-26 1.2E-30 260.6 0.0 462 37-506 32-503 (517) 23 6B7H_A Metabotropic glutamate 99.8 1.6E-26 1.2E-30 260.6 0.0 462 37-506 32-503 (517) 24 1EWK_B METABOTROPIC GLUTAMATE 99.8 1.8E-26 1.3E-30 258.4 0.0 464 38-506 5-484 (490) 25 1EWT_A METABOTROPIC GLUTAMATE 99.8 1.8E-26 1.3E-30 258.4 0.0 464 38-506 5-484 (490) 26 5C5C_A Metabotropic glutamate 99.8 2E-26 1.4E-30 257.7 0.0 468 38-505 9-480 (481) 27 3SM9_A Metabotropic glutamate 99.8 2.4E-26 1.7E-30 256.8 0.0 459 40-506 8-476 (479) 28 4XAQ_A Metabotropic glutamate 99.8 9.3E-26 6.8E-30 253.4 0.0 453 40-506 28-491 (503) 29 5CNI_A Metabotropic glutamate 99.8 9.3E-26 6.8E-30 253.4 0.0 453 40-506 28-491 (503) 30 5CNJ_A Metabotropic glutamate 99.8 1.1E-25 7.8E-30 252.8 0.0 454 39-506 27-491 (503) 31 5FBK_A Extracellular calcium-s 99.8 3.8E-25 2.8E-29 252.0 0.0 460 40-507 53-560 (568) 32 5FBK_B Extracellular calcium-s 99.8 4.7E-25 3.4E-29 251.3 0.0 460 40-507 53-560 (568) 33 1DP4_A ATRIAL NATRIURETIC PEPT 99.8 2.8E-24 2E-28 236.6 0.0 369 44-494 1-397 (435) 34 1DP4_C ATRIAL NATRIURETIC PEPT 99.8 2.8E-24 2E-28 236.6 0.0 369 44-494 1-397 (435) 35 5X2M_A Taste receptor, type 1, 99.8 4.3E-24 3.1E-28 237.0 0.0 419 35-494 4-432 (461) 36 5X2N_C Taste receptor, type 1, 99.8 4.3E-24 3.1E-28 237.0 0.0 419 35-494 4-432 (461) 37 5X2M_B Taste receptor, type 1, 99.8 1.5E-23 1.1E-27 233.8 0.0 440 39-512 12-470 (478) 38 5X2N_B Taste receptor, type 1, 99.8 1.5E-23 1.1E-27 233.8 0.0 440 39-512 12-470 (478) 39 5X2N_D Taste receptor, type 1, 99.8 1.5E-23 1.1E-27 233.8 0.0 440 39-512 12-470 (478) 40 1JDN_A ATRIAL NATRIURETIC PEPT 99.8 2E-23 1.4E-27 230.1 0.0 372 41-494 5-395 (441) 41 1JDP_A ATRIAL NATRIURETIC PEPT 99.8 2E-23 1.4E-27 230.1 0.0 372 41-494 5-395 (441) 42 4F11_A Gamma-aminobutyric acid 99.7 2E-22 1.4E-26 221.5 0.0 391 39-506 8-419 (433) 43 4MS4_B Gamma-aminobutyric acid 99.7 2E-22 1.4E-26 221.5 0.0 391 39-506 8-419 (433) 44 4MQE_A Gamma-aminobutyric acid 99.7 2E-21 1.4E-25 212.4 0.0 376 43-494 3-392 (420) 45 4MS4_A Gamma-aminobutyric acid 99.7 2E-21 1.4E-25 212.4 0.0 376 43-494 3-392 (420) 46 3Q41_C Glutamate [NMDA] recept 99.7 4.8E-21 3.4E-25 206.5 0.0 348 42-507 3-364 (384) 47 5KC8_A Glutamate receptor iono 99.6 9.9E-21 7.1E-25 207.4 0.0 378 42-495 3-403 (429) 48 3OM0_A Glutamate receptor, ion 99.6 2.1E-20 1.5E-24 201.9 0.0 370 43-495 2-376 (393) 49 3QLU_B Glutamate receptor, ion 99.6 2.1E-20 1.5E-24 201.9 0.0 370 43-495 2-376 (393) 50 5FWY_B GLUTAMATE RECEPTOR 2, G 99.6 2.4E-20 1.7E-24 201.4 0.0 372 43-505 3-385 (390) 51 6FPJ_A Glutamate receptor 3; l 99.6 2.4E-20 1.7E-24 201.4 0.0 372 43-505 3-385 (390) 52 3H5L_A putative Branched-chain 99.6 2.8E-20 2.1E-24 203.0 0.0 363 40-493 9-385 (419) 53 3H5L_B putative Branched-chain 99.6 2.8E-20 2.1E-24 203.0 0.0 363 40-493 9-385 (419) 54 5KCA_A Cerebellin-1,Cerebellin 99.6 4.6E-20 3.3E-24 221.1 0.0 382 40-496 452-855 (878) 55 4XFK_A BrovA.17370.a; transpor 99.6 5.4E-20 3.9E-24 199.1 0.0 355 43-493 9-374 (399) 56 5KC9_A Glutamate receptor iono 99.6 5.6E-20 4.1E-24 201.2 0.0 372 42-495 3-402 (428) 57 6JFY_A Glutamate receptor iono 99.6 1.1E-19 7.8E-24 216.7 0.0 373 43-494 2-380 (809) 58 4GPA_A Glutamate receptor 4; P 99.6 1.1E-19 7.9E-24 196.1 0.0 361 43-496 3-374 (389) 59 5EWM_A NMDA glutamate receptor 99.6 1.2E-19 8.4E-24 195.9 0.0 351 43-507 2-383 (390) 60 3H6G_A Glutamate receptor, ion 99.6 1.2E-19 8.7E-24 196.1 0.0 373 43-495 2-378 (395) 61 3H6G_B Glutamate receptor, ion 99.6 1.2E-19 8.7E-24 196.1 0.0 373 43-495 2-378 (395) 62 6JFY_B Glutamate receptor iono 99.6 1.2E-19 8.9E-24 216.1 0.0 373 43-494 2-380 (809) 63 5L2E_B Cerebellin-1; Synapse P 99.6 1.3E-19 9.3E-24 211.8 0.0 379 42-495 2-402 (688) 64 3QEK_B NMDA glutamate receptor 99.6 1.3E-19 9.4E-24 195.1 0.0 349 43-505 3-382 (384) 65 6LU9_D Glutamate receptor iono 99.6 1.3E-19 9.6E-24 218.0 0.0 374 44-494 2-399 (877) 66 1USG_A LEUCINE-SPECIFIC BINDIN 99.6 2.1E-19 1.5E-23 190.1 0.0 335 44-477 1-337 (346) 67 3IP6_A ABC transporter, substr 99.6 2.6E-19 1.9E-23 190.4 0.0 349 44-493 1-351 (356) 68 3IPC_A ABC transporter, substr 99.6 2.7E-19 2E-23 190.1 0.0 348 45-493 2-351 (356) 69 4EYG_B Twin-arginine transloca 99.5 3.1E-19 2.3E-23 190.7 0.0 356 42-494 3-360 (368) 70 4EYK_A Twin-arginine transloca 99.5 3.1E-19 2.3E-23 190.7 0.0 356 42-494 3-360 (368) 71 3HUT_A putative branched-chain 99.5 4E-19 2.9E-23 189.0 0.0 350 43-493 2-353 (358) 72 5KUH_C Glutamate receptor iono 99.5 4.1E-19 3E-23 210.0 0.0 372 43-495 2-378 (757) 73 4EVQ_A Putative ABC transporte 99.5 4.1E-19 3E-23 190.4 0.0 352 39-491 10-361 (375) 74 4EVQ_B Putative ABC transporte 99.5 4.1E-19 3E-23 190.4 0.0 352 39-491 10-361 (375) 75 4N0Q_B Leu/Ile/Val-binding pro 99.5 4.2E-19 3E-23 188.6 0.0 336 43-477 8-346 (354) 76 4N0Q_C Leu/Ile/Val-binding pro 99.5 4.2E-19 3E-23 188.6 0.0 336 43-477 8-346 (354) 77 3SAJ_C Glutamate receptor 1; R 99.5 4.5E-19 3.3E-23 190.7 0.0 357 41-495 6-372 (384) 78 6E7R_B Glutamate receptor iono 99.5 6E-19 4.4E-23 188.1 0.0 348 44-505 2-361 (363) 79 6E7S_D Glutamate receptor iono 99.5 6E-19 4.4E-23 188.1 0.0 348 44-505 2-361 (363) 80 3HSY_B Glutamate receptor 2; G 99.5 6.1E-19 4.5E-23 188.9 0.0 357 44-495 1-369 (376) 81 3SAJ_B Glutamate receptor 1; R 99.5 6.5E-19 4.7E-23 189.5 0.0 357 41-495 6-372 (384) 82 3N6V_D Glutamate receptor 2; A 99.5 6.9E-19 5E-23 188.4 0.0 355 46-495 1-367 (374) 83 4GNR_A ABC transporter substra 99.5 7E-19 5.1E-23 186.7 0.0 347 41-492 3-352 (353) 84 3N0X_A Possible substrate bind 99.5 7.4E-19 5.3E-23 188.3 0.0 348 43-494 2-355 (374) 85 6KSP_B Glutamate receptor iono 99.5 7.5E-19 5.4E-23 210.7 0.0 372 44-494 2-398 (856) 86 3N6V_B Glutamate receptor 2; A 99.5 8.3E-19 6E-23 187.8 0.0 355 46-495 1-367 (374) 87 1Z17_A Leu/Ile/Val-binding pro 99.5 8.4E-19 6.1E-23 185.2 0.0 333 45-478 2-336 (344) 88 4RU0_B Putative branched-chain 99.5 1E-18 7.4E-23 192.3 0.0 370 40-494 28-416 (447) 89 5EWM_D NMDA glutamate receptor 99.5 1E-18 7.5E-23 186.3 0.0 349 43-505 2-362 (364) 90 4MLC_A Extracellular ligand-bi 99.5 1.1E-18 7.8E-23 185.4 0.0 346 40-489 5-355 (356) 91 4Q6B_A Extracellular ligand-bi 99.5 1.1E-18 7.8E-23 185.4 0.0 346 40-489 5-355 (356) 92 3TD9_A Branched chain amino ac 99.5 1.1E-18 8.1E-23 186.2 0.0 347 43-494 14-363 (366) 93 3N0W_B ABC branched chain amin 99.5 1.7E-18 1.2E-22 185.8 0.0 350 42-493 3-354 (379) 94 1PEA_A AMIDASE OPERON, ACETAMI 99.5 1.8E-18 1.3E-22 186.1 0.0 354 42-493 4-359 (385) 95 1QO0_B AMIC, AMIR; BINDING PRO 99.5 1.8E-18 1.3E-22 186.1 0.0 354 42-493 4-359 (385) 96 4KV7_A Probable leucine/isoleu 99.5 1.9E-18 1.4E-22 185.5 0.0 349 38-477 10-366 (381) 97 4OBB_B Amino acid/amide ABC tr 99.5 2E-18 1.5E-22 186.4 0.0 362 39-492 27-392 (395) 98 4RV5_B Amino acid/amide ABC tr 99.5 2E-18 1.5E-22 186.4 0.0 362 39-492 27-392 (395) 99 3I45_A Twin-arginine transloca 99.5 2.3E-18 1.6E-22 185.4 0.0 355 43-494 3-360 (387) 100 4F06_A Extracellular ligand-bi 99.5 2.9E-18 2.1E-22 183.2 0.0 356 42-492 2-361 (371) 101 4N03_A ABC-type branched-chain 99.5 4.8E-18 3.5E-22 184.1 0.0 356 40-494 28-392 (405) 102 4M88_A Extracellular ligand-bi 99.5 4.9E-18 3.5E-22 180.4 0.0 343 43-477 2-350 (357) 103 3I09_B Periplasmic branched-ch 99.5 6.2E-18 4.5E-22 181.0 0.0 347 43-492 2-349 (375) 104 5TQ0_B NMDA glutamate receptor 99.4 6.5E-18 4.7E-22 179.7 0.0 343 46-505 1-358 (360) 105 5TPW_B NMDA glutamate receptor 99.4 6.5E-18 4.7E-22 179.7 0.0 343 46-505 1-358 (360) 106 4MAA_A Putative branched-chain 99.4 9.1E-18 6.6E-22 181.7 0.0 352 40-494 29-383 (403) 107 5L1B_D Glutamate receptor 2; T 99.4 1.1E-17 8.2E-22 198.8 0.0 356 44-494 1-368 (803) 108 4TLL_D GluN1/GluN2B; Neurotran 99.4 1.3E-17 9.1E-22 199.0 0.0 340 40-494 5-358 (824) 109 4TLM_D GluN1/GluN2B; neurotran 99.4 1.3E-17 9.1E-22 199.0 0.0 340 40-494 5-358 (824) 110 4EYQ_A Extracellular ligand-bi 99.4 1.8E-17 1.3E-21 176.2 0.0 348 41-477 3-354 (362) 111 3LKB_B Probable branched-chain 99.4 1.9E-17 1.4E-21 178.4 0.0 360 42-494 4-375 (392) 112 4F8J_A Putative branched-chain 99.4 2.8E-17 2E-21 174.7 0.0 348 41-477 3-354 (362) 113 4U4G_D GluA2*; Ionotropic glut 99.4 2.9E-17 2.1E-21 195.8 0.0 356 44-494 1-368 (822) 114 6PEQ_D Glutamate receptor 2, P 99.4 3.4E-17 2.4E-21 196.9 0.0 360 40-494 21-392 (889) 115 3UK0_A Extracellular ligand-bi 99.4 3.5E-17 2.6E-21 173.9 0.0 348 41-477 3-354 (362) 116 4TLL_C GluN1/GluN2B; Neurotran 99.4 3.6E-17 2.6E-21 194.8 0.0 349 43-507 3-363 (823) 117 4TLM_C GluN1/GluN2B; neurotran 99.4 3.6E-17 2.6E-21 194.8 0.0 349 43-507 3-363 (823) 118 4MPT_B Putative leu/ile/val-bi 99.4 3.6E-17 2.6E-21 175.3 0.0 354 42-477 3-367 (380) 119 4ZPJ_A Extracellular ligand-bi 99.4 5.1E-17 3.7E-21 177.0 0.0 346 39-476 48-399 (423) 120 6DLZ_B Glutamate receptor 2,Vo 99.4 5.2E-17 3.7E-21 198.5 0.0 356 44-494 1-368 (1031) 121 3EAF_A ABC transporter, substr 99.4 6.6E-17 4.8E-21 174.0 0.0 362 43-494 2-372 (391) 122 5UOW_C N-methyl-D-aspartate re 99.4 6.8E-17 4.9E-21 192.2 0.0 336 43-494 2-348 (814) 123 3LOP_A Substrate binding perip 99.4 7.1E-17 5.1E-21 171.9 0.0 352 43-492 3-360 (364) 124 5IOV_B GluN1, GLY-GLY-GLU-GLU; 99.4 7.4E-17 5.4E-21 192.2 0.0 341 39-494 23-377 (825) 125 5WEO_A Glutamate receptor 2,Vo 99.3 1.3E-16 9.5E-21 195.0 0.0 356 44-494 1-368 (1034) 126 4DQD_A Extracellular ligand-bi 99.3 1.9E-16 1.4E-20 168.3 0.0 348 43-477 2-355 (363) 127 3SG0_A Extracellular ligand-bi 99.3 3.9E-16 2.8E-20 167.4 0.0 350 41-477 23-378 (386) 128 5ERE_A Extracellular ligand-bi 99.3 4.6E-16 3.3E-20 176.6 0.0 327 45-494 1-327 (568) 129 3CKM_A Uncharacterized protein 99.2 3.7E-15 2.7E-19 155.6 0.0 322 44-493 1-324 (327) 130 5VBG_A Penicillin-binding prot 98.9 1.6E-13 1.2E-17 154.3 0.0 215 40-311 219-434 (543) 131 5KCN_A Penicillin-binding prot 98.9 1.6E-13 1.2E-17 154.2 0.0 215 40-311 219-434 (543) 132 4PYR_A Putative branched-chain 98.9 1.7E-13 1.2E-17 141.2 0.0 204 45-311 1-205 (305) 133 4YLE_A Simple sugar transport 97.8 1.5E-08 1.1E-12 103.5 0.0 224 40-308 27-256 (316) 134 4RK1_B Ribose transcriptional 97.7 2.9E-08 2.1E-12 99.2 0.0 204 42-300 4-209 (280) 135 4RK1_D Ribose transcriptional 97.7 2.9E-08 2.1E-12 99.2 0.0 204 42-300 4-209 (280) 136 3BRQ_A HTH-type transcriptiona 97.6 3.8E-08 2.7E-12 99.3 0.0 208 41-300 15-225 (296) 137 3BRQ_B HTH-type transcriptiona 97.6 3.8E-08 2.7E-12 99.3 0.0 208 41-300 15-225 (296) 138 5DTE_B Monosaccharide-transpor 97.6 5.2E-08 3.8E-12 99.3 0.0 222 41-308 22-249 (311) 139 3KSM_B ABC-type sugar transpor 97.6 5.5E-08 4E-12 96.9 0.0 212 46-308 1-220 (276) 140 3KSM_A ABC-type sugar transpor 97.6 5.5E-08 4E-12 96.9 0.0 212 46-308 1-220 (276) 141 4RSM_A Periplasmic binding pro 97.6 5.6E-08 4.1E-12 99.9 0.0 213 40-308 7-226 (327) 142 6HBD_B ABC transporter peripla 97.6 5.7E-08 4.1E-12 99.4 0.0 211 39-300 11-230 (320) 143 4JOQ_A ABC ribose transporter, 97.6 6.4E-08 4.6E-12 97.7 0.0 218 42-308 4-226 (297) 144 4JOQ_B ABC ribose transporter, 97.6 6.4E-08 4.6E-12 97.7 0.0 218 42-308 4-226 (297) 145 5HSG_A Putative ABC transporte 97.5 7E-08 5.1E-12 98.2 0.0 214 41-308 21-243 (310) 146 2O20_B Catabolite control prot 97.5 8.3E-08 6E-12 98.8 0.0 203 42-300 60-264 (332) 147 2O20_F Catabolite control prot 97.5 8.3E-08 6E-12 98.8 0.0 203 42-300 60-264 (332) 148 4YO7_A Sugar ABC transporter ( 97.5 8.5E-08 6.2E-12 98.4 0.0 216 40-308 40-261 (326) 149 6GQ0_A Putative sugar binding 97.5 9.5E-08 6.9E-12 97.6 0.0 220 35-308 20-246 (318) 150 6GT9_C Putative sugar binding 97.5 9.5E-08 6.9E-12 97.6 0.0 220 35-308 20-246 (318) 151 1GUB_A D-ALLOSE-BINDING PERIPL 97.5 1E-07 7.3E-12 95.6 0.0 218 45-308 1-226 (288) 152 1GUD_B D-ALLOSE-BINDING PERIPL 97.5 1E-07 7.3E-12 95.6 0.0 218 45-308 1-226 (288) 153 1DBQ_B PURINE REPRESSOR; TRANS 97.5 1.1E-07 7.8E-12 95.4 0.0 205 42-300 4-212 (289) 154 4RK0_D LacI family sugar-bindi 97.5 1.2E-07 8.7E-12 94.2 0.0 198 42-300 4-203 (274) 155 3DBI_A SUGAR-BINDING TRANSCRIP 97.4 1.3E-07 9.1E-12 97.6 0.0 207 42-300 58-267 (338) 156 3DBI_C SUGAR-BINDING TRANSCRIP 97.4 1.3E-07 9.1E-12 97.6 0.0 207 42-300 58-267 (338) 157 3EGC_F putative ribose operon 97.4 1.5E-07 1.1E-11 94.6 0.0 205 41-300 4-211 (291) 158 4KZK_A L-arabinose-binding pro 97.4 1.6E-07 1.1E-11 96.8 0.0 218 40-308 31-265 (337) 159 3O1I_C Sensor protein TorS (E. 97.4 1.6E-07 1.1E-11 95.1 0.0 216 43-308 3-226 (304) 160 3O1I_D Sensor protein TorS (E. 97.4 1.6E-07 1.1E-11 95.1 0.0 216 43-308 3-226 (304) 161 3O1J_C Sensor protein TorS (E. 97.4 1.6E-07 1.1E-11 95.1 0.0 216 43-308 3-226 (304) 162 4YHS_A ABC TRANSPORTER SOLUTE 97.4 1.6E-07 1.1E-11 97.7 0.0 215 40-308 53-276 (354) 163 3CLK_B Transcription regulator 97.4 1.6E-07 1.2E-11 94.3 0.0 205 41-300 4-210 (290) 164 2RGY_A Transcriptional regulat 97.4 1.6E-07 1.2E-11 94.2 0.0 208 41-300 4-214 (290) 165 6HB0_A ABC transporter peripla 97.4 1.8E-07 1.3E-11 95.7 0.0 211 39-300 13-232 (322) 166 1SXG_D Glucose-resistance amyl 97.4 1.8E-07 1.3E-11 93.2 0.0 204 42-300 5-212 (280) 167 2NZV_G Catabolite control prot 97.4 1.8E-07 1.3E-11 93.2 0.0 204 42-300 5-212 (280) 168 4RS3_A ABC transporter, carboh 97.4 1.9E-07 1.4E-11 95.7 0.0 213 40-308 7-226 (327) 169 5OCP_A Periplasmic binding pro 97.4 2E-07 1.5E-11 94.3 0.0 203 47-300 2-212 (302) 170 3BIL_A Probable LacI-family tr 97.4 2.1E-07 1.5E-11 96.4 0.0 202 42-300 63-266 (348) 171 3O74_A Fructose transport syst 97.3 2.3E-07 1.6E-11 91.9 0.0 200 45-300 2-205 (272) 172 3O74_B Fructose transport syst 97.3 2.3E-07 1.6E-11 91.9 0.0 200 45-300 2-205 (272) 173 4Z0N_A Periplasmic Solute Bind 97.3 2.3E-07 1.7E-11 95.6 0.0 222 40-309 26-265 (337) 174 4PE6_B solute binding protein; 97.3 2.3E-07 1.7E-11 95.8 0.0 210 40-299 13-228 (341) 175 2X7X_A SENSOR PROTEIN (E.C.2.7 97.3 2.4E-07 1.7E-11 95.0 0.0 213 42-308 3-221 (325) 176 2X7X_B SENSOR PROTEIN (E.C.2.7 97.3 2.4E-07 1.7E-11 95.0 0.0 213 42-308 3-221 (325) 177 4RXM_A Possible sugar ABC supe 97.3 2.4E-07 1.8E-11 92.9 0.0 205 43-300 2-213 (292) 178 2HSG_A Glucose-resistance amyl 97.3 2.5E-07 1.8E-11 95.1 0.0 204 42-300 57-264 (332) 179 1ZHH_A Autoinducer 2-binding p 97.3 2.5E-07 1.8E-11 95.7 0.0 220 42-308 42-268 (344) 180 5ULB_A Putative sugar ABC tran 97.3 2.6E-07 1.9E-11 95.1 0.0 217 38-308 12-237 (337) 181 2FEP_A Catabolite control prot 97.3 2.7E-07 1.9E-11 92.6 0.0 206 40-300 11-220 (289) 182 2IKS_A DNA-binding transcripti 97.3 2.7E-07 2E-11 92.6 0.0 204 41-300 16-222 (293) 183 3D8U_A PurR transcriptional re 97.3 2.7E-07 2E-11 91.5 0.0 202 44-300 2-206 (275) 184 3D8U_B PurR transcriptional re 97.3 2.7E-07 2E-11 91.5 0.0 202 44-300 2-206 (275) 185 1JHZ_B PURINE NUCLEOTIDE SYNTH 97.3 2.7E-07 2E-11 92.4 0.0 206 41-300 3-212 (289) 186 2P9H_A Lactose operon represso 97.3 2.8E-07 2.1E-11 91.0 0.0 199 46-300 1-202 (269) 187 2PAF_B Lactose operon represso 97.3 2.8E-07 2.1E-11 91.0 0.0 199 46-300 1-202 (269) 188 3K4H_A putative transcriptiona 97.3 2.9E-07 2.1E-11 92.4 0.0 210 42-300 5-217 (292) 189 4RXT_A Sugar ABC transporter; 97.3 3E-07 2.1E-11 92.8 0.0 213 43-308 2-226 (299) 190 4ZJP_A solute binding protein; 97.3 3E-07 2.2E-11 92.3 0.0 206 38-299 17-229 (292) 191 2VK2_A ABC TRANSPORTER PERIPLA 97.3 3.2E-07 2.3E-11 92.9 0.0 205 45-300 2-216 (306) 192 1JFT_A PURINE NUCLEOTIDE SYNTH 97.3 3.2E-07 2.3E-11 94.5 0.0 206 41-300 54-263 (340) 193 3BRS_B Periplasmic binding pro 97.3 3.3E-07 2.4E-11 91.8 0.0 215 43-308 3-223 (289) 194 4RK4_A Transcriptional regulat 97.3 3.4E-07 2.4E-11 91.3 0.0 205 41-300 5-216 (283) 195 4RK5_A Transcriptional regulat 97.3 3.4E-07 2.4E-11 91.3 0.0 205 41-300 5-216 (283) 196 2QU7_B Putative transcriptiona 97.3 3.6E-07 2.6E-11 91.5 0.0 200 42-300 5-212 (288) 197 4IRX_B Sugar ABC transporter, 97.3 3.7E-07 2.7E-11 91.8 0.0 208 41-300 4-219 (296) 198 4RY9_A Periplasmic binding pro 97.2 3.9E-07 2.8E-11 91.9 0.0 205 42-300 4-223 (302) 199 3G1W_A Sugar ABC transporter; 97.2 4E-07 2.9E-11 92.1 0.0 213 43-308 2-220 (305) 200 3G1W_B Sugar ABC transporter; 97.2 4E-07 2.9E-11 92.1 0.0 213 43-308 2-220 (305) 201 5XSD_B Periplasmic binding pro 97.2 4.3E-07 3.1E-11 91.9 0.0 217 40-309 13-235 (306) 202 5DKV_A ABC transporter substra 97.2 4.3E-07 3.1E-11 92.8 0.0 219 42-308 24-253 (324) 203 1ZVV_B Glucose-resistance amyl 97.2 4.3E-07 3.2E-11 93.1 0.0 204 42-300 57-264 (332) 204 4KQ9_A Ribose ABC transporter, 97.2 4.6E-07 3.3E-11 91.2 0.0 205 42-299 4-214 (299) 205 5XSS_A Periplasmic binding pro 97.2 4.8E-07 3.5E-11 92.1 0.0 217 39-308 22-244 (316) 206 4YR7_A LuxP; PROTEIN-LIGAND CO 97.2 5.1E-07 3.7E-11 93.2 0.0 222 42-308 43-269 (345) 207 2IOY_A Periplasmic sugar-bindi 97.2 5.3E-07 3.8E-11 90.0 0.0 208 46-308 2-215 (283) 208 1TLF_C TRYPTIC CORE FRAGMENT O 97.2 5.3E-07 3.8E-11 91.0 0.0 200 45-300 2-204 (301) 209 3OQO_C Catabolite control prot 97.2 5.3E-07 3.8E-11 92.8 0.0 204 42-300 57-264 (339) 210 4RK6_A Glucose-resistance amyl 97.2 5.4E-07 3.9E-11 90.0 0.0 205 40-300 5-214 (287) 211 4RK7_B Glucose-resistance amyl 97.2 5.4E-07 3.9E-11 90.0 0.0 205 40-300 5-214 (287) 212 4RWE_A Sugar-binding transport 97.2 6E-07 4.3E-11 90.0 0.0 213 43-308 3-220 (292) 213 3GV0_A Transcriptional regulat 97.2 6.1E-07 4.4E-11 89.8 0.0 207 41-300 4-213 (288) 214 5HKO_A ABC transporter, carboh 97.2 6.3E-07 4.6E-11 92.7 0.0 214 40-309 28-248 (348) 215 4RXU_A Periplasmic sugar-bindi 97.2 6.5E-07 4.7E-11 93.4 0.0 153 39-241 24-182 (367) 216 4KMR_A Transcriptional regulat 97.1 6.7E-07 4.9E-11 88.9 0.0 201 44-300 2-208 (280) 217 3L6U_A ABC-TYPE SUGAR TRANSPOR 97.1 6.8E-07 4.9E-11 89.7 0.0 205 42-300 5-220 (293) 218 2DRI_A D-RIBOSE-BINDING PROTEI 97.1 6.8E-07 4.9E-11 88.2 0.0 207 46-308 2-214 (271) 219 3D02_A Putative LACI-type tran 97.1 6.9E-07 5E-11 90.1 0.0 214 43-308 2-222 (303) 220 4WZZ_A ABC TRANSPORTER SOLUTE 97.1 7.2E-07 5.2E-11 93.2 0.0 215 41-308 50-273 (371) 221 1JX6_A LUXP PROTEIN; PROTEIN-L 97.1 7.2E-07 5.2E-11 91.9 0.0 222 42-308 40-266 (342) 222 4WT7_A ABC TRANSPORTER SOLUTE 97.1 7.7E-07 5.5E-11 90.8 0.0 202 42-299 29-242 (321) 223 2RJO_A Twin-arginine transloca 97.1 8.7E-07 6.3E-11 90.9 0.0 217 43-307 3-229 (332) 224 4Y9T_A ABC TRANSPORTER SOLUTE 97.1 8.9E-07 6.5E-11 91.4 0.0 205 42-300 24-239 (346) 225 4RU1_A Monosaccharide ABC tran 97.1 9.1E-07 6.6E-11 89.3 0.0 206 39-299 14-223 (304) 226 4YV7_A ABC TRANSPORTER SOLUTE 97.1 9.4E-07 6.8E-11 90.2 0.0 215 39-309 34-255 (326) 227 2FN9_B ribose ABC transporter, 97.1 1E-06 7.3E-11 88.2 0.0 202 45-299 2-215 (290) 228 4XXH_B PROTEIN (TREHALOSE OPER 97.1 1E-06 7.4E-11 86.1 0.0 192 45-299 2-196 (255) 229 5IX8_B Putative sugar ABC tran 97.0 1.1E-06 8.2E-11 89.4 0.0 208 40-299 10-224 (321) 230 4WUT_A ABC TRANSPORTER SOLUTE 97.0 1.1E-06 8.2E-11 89.0 0.0 222 39-308 17-244 (313) 231 3HCW_A Maltose operon transcri 97.0 1.2E-06 8.5E-11 88.0 0.0 207 42-299 4-216 (295) 232 1JYE_A Lactose Operon Represso 97.0 1.2E-06 9E-11 90.4 0.0 203 42-300 58-263 (349) 233 2PE5_B Lactose operon represso 97.0 1.3E-06 9.2E-11 89.4 0.0 203 42-300 57-262 (330) 234 3C3K_B Alanine racemase (E.C.5 97.0 1.3E-06 9.5E-11 87.1 0.0 203 41-300 4-209 (285) 235 8ABP_A L-ARABINOSE-BINDING PRO 97.0 1.3E-06 9.6E-11 88.1 0.0 214 45-308 2-231 (306) 236 5ABP_A L-ARABINOSE-BINDING PRO 97.0 1.3E-06 9.7E-11 88.1 0.0 214 45-308 2-231 (306) 237 4KVF_A Rhamnose ABC transporte 97.0 1.5E-06 1.1E-10 89.5 0.0 217 39-307 33-257 (342) 238 3EDC_D Lactose operon represso 97.0 1.5E-06 1.1E-10 90.2 0.0 204 41-300 57-263 (360) 239 3KJX_D Transcriptional regulat 97.0 1.6E-06 1.1E-10 89.4 0.0 204 42-300 65-272 (344) 240 3KJX_C Transcriptional regulat 97.0 1.6E-06 1.1E-10 89.4 0.0 204 42-300 65-272 (344) 241 1GLG_A GALACTOSE/GLUCOSE-BINDI 97.0 1.6E-06 1.1E-10 87.7 0.0 217 45-309 2-236 (309) 242 2FVY_A D-galactose-binding per 97.0 1.6E-06 1.1E-10 87.7 0.0 217 45-309 2-236 (309) 243 3M9W_A D-xylose-binding peripl 97.0 1.6E-06 1.2E-10 87.9 0.0 211 45-308 2-221 (313) 244 3MA0_A D-xylose-binding peripl 97.0 1.6E-06 1.2E-10 87.9 0.0 211 45-308 2-221 (313) 245 3MA0_C D-xylose-binding peripl 97.0 1.6E-06 1.2E-10 87.9 0.0 211 45-308 2-221 (313) 246 5IBQ_A Probable ribose ABC tra 97.0 1.6E-06 1.2E-10 87.8 0.0 217 38-308 17-239 (310) 247 3K9C_B Transcriptional regulat 97.0 1.7E-06 1.2E-10 86.5 0.0 201 41-300 8-210 (289) 248 4RY8_B Periplasmic binding pro 97.0 1.7E-06 1.3E-10 88.4 0.0 215 40-308 10-230 (329) 249 4RY8_C Periplasmic binding pro 97.0 1.7E-06 1.3E-10 88.4 0.0 215 40-308 10-230 (329) 250 3ROT_A ABC sugar transporter, 96.9 1.9E-06 1.4E-10 86.6 0.0 205 44-299 2-212 (297) 251 3ROT_B ABC sugar transporter, 96.9 1.9E-06 1.4E-10 86.6 0.0 205 44-299 2-212 (297) 252 5BRA_A Putative periplasmic bi 96.9 1.9E-06 1.4E-10 89.0 0.0 220 37-308 36-262 (350) 253 2H3H_A Sugar ABC transporter, 96.9 1.9E-06 1.4E-10 87.3 0.0 209 45-308 1-215 (313) 254 2H3H_B Sugar ABC transporter, 96.9 1.9E-06 1.4E-10 87.3 0.0 209 45-308 1-215 (313) 255 3GBV_A Putative LacI-family tr 96.9 1.9E-06 1.4E-10 86.8 0.0 155 42-242 5-168 (304) 256 3HUU_A Transcription regulator 96.9 2.3E-06 1.7E-10 86.2 0.0 205 41-299 18-226 (305) 257 3HUU_C Transcription regulator 96.9 2.3E-06 1.7E-10 86.2 0.0 205 41-299 18-226 (305) 258 3KKE_C LacI family Transcripti 96.9 2.5E-06 1.8E-10 85.9 0.0 205 40-300 10-222 (303) 259 3KKE_B LacI family Transcripti 96.9 2.5E-06 1.8E-10 85.9 0.0 205 40-300 10-222 (303) 260 3BBL_A Regulatory protein of L 96.9 2.6E-06 1.9E-10 84.9 0.0 146 145-300 63-213 (287) 261 4PZ0_A sugar ABC transporter, 96.9 2.8E-06 2E-10 86.6 0.0 213 41-307 6-227 (324) 262 4YS6_A ABC TRANSPORTER SOLUTE 96.8 2.8E-06 2E-10 88.1 0.0 217 40-307 31-270 (360) 263 3L49_C ABC sugar (Ribose) tran 96.8 2.9E-06 2.1E-10 84.7 0.0 203 43-299 3-215 (291) 264 3JY6_A Transcriptional regulat 96.8 3E-06 2.1E-10 84.0 0.0 199 42-300 4-206 (276) 265 3JY6_D Transcriptional regulat 96.8 3E-06 2.1E-10 84.0 0.0 199 42-300 4-206 (276) 266 5HQJ_A Periplasmic binding pro 96.8 3E-06 2.2E-10 85.7 0.0 204 40-297 23-232 (311) 267 3EJW_A SmLsrB; Periplasmic bin 96.8 3.3E-06 2.4E-10 85.6 0.0 211 45-308 1-220 (315) 268 3QK7_C Transcriptional regulat 96.8 3.3E-06 2.4E-10 84.5 0.0 207 42-300 3-212 (294) 269 3E3M_D Transcriptional regulat 96.8 3.3E-06 2.4E-10 87.3 0.0 204 42-300 67-275 (355) 270 2WRZ_A L-ARABINOSE-BINDING PER 96.8 3.5E-06 2.5E-10 84.9 0.0 206 45-300 2-222 (306) 271 5BQ3_A Rhamnose ABC transporte 96.8 3.7E-06 2.7E-10 85.9 0.0 218 39-308 21-248 (332) 272 4RY0_A Probable ribose ABC tra 96.8 3.9E-06 2.8E-10 83.6 0.0 211 44-308 2-218 (289) 273 3TB6_A Arabinose metabolism tr 96.7 4.4E-06 3.2E-10 83.7 0.0 206 41-300 11-226 (298) 274 3GYB_A Transcriptional regulat 96.7 5.4E-06 3.9E-10 82.2 0.0 198 43-300 3-201 (280) 275 3GYB_B Transcriptional regulat 96.7 5.4E-06 3.9E-10 82.2 0.0 198 43-300 3-201 (280) 276 5UFH_A LacI-type transcription 96.7 5.9E-06 4.3E-10 85.0 0.0 202 43-300 63-278 (347) 277 3CTP_A Periplasmic binding pro 96.7 6E-06 4.3E-10 84.3 0.0 198 42-300 57-256 (330) 278 3G85_A Transcriptional regulat 96.7 6E-06 4.3E-10 82.3 0.0 204 41-300 7-213 (289) 279 3H5O_B Transcriptional regulat 96.7 6.1E-06 4.4E-10 84.6 0.0 203 42-300 59-264 (339) 280 5YSZ_A Transcriptional regulat 96.6 7.5E-06 5.4E-10 84.8 0.0 148 145-300 143-293 (360) 281 3MIZ_A Putative transcriptiona 96.6 8.6E-06 6.2E-10 81.7 0.0 206 41-300 9-222 (301) 282 1TJY_A sugar transport protein 96.6 9.4E-06 6.8E-10 82.2 0.0 210 44-308 2-221 (316) 283 4O5A_A LacI family transcripti 96.5 9.7E-06 7E-10 83.2 0.0 207 42-300 65-274 (345) 284 3UUG_B Multiple sugar-binding 96.5 1.2E-05 8.5E-10 82.0 0.0 206 44-300 2-229 (330) 285 3LKV_A uncharacterized CONSERV 96.5 1.3E-05 9.7E-10 80.1 0.0 215 41-308 4-226 (302) 286 4KQC_A Periplasmic binding pro 96.4 1.8E-05 1.3E-09 80.1 0.0 209 43-299 2-229 (319) 287 4WWH_A ABC TRANSPORTER SOLUTE 96.4 1.8E-05 1.3E-09 81.9 0.0 210 40-300 30-261 (362) 288 3CS3_A Sugar-binding transcrip 96.4 1.8E-05 1.3E-09 78.0 0.0 194 42-300 5-202 (277) 289 2H0A_A Transcriptional regulat 96.3 2.4E-05 1.7E-09 77.0 0.0 144 145-300 54-205 (276) 290 3E61_B Putative transcriptiona 96.3 2.5E-05 1.8E-09 77.0 0.0 197 41-300 4-202 (277) 291 3E61_A Putative transcriptiona 96.3 2.5E-05 1.8E-09 77.0 0.0 197 41-300 4-202 (277) 292 6HNI_A ABC-type transport syst 96.2 3.4E-05 2.4E-09 77.9 0.0 218 39-307 17-240 (319) 293 6HNJ_A ABC-type transport syst 96.2 3.4E-05 2.4E-09 77.9 0.0 218 39-307 17-240 (319) 294 3H75_A Periplasmic sugar-bindi 96.2 3.8E-05 2.7E-09 78.9 0.0 212 44-300 2-230 (350) 295 4RKQ_A Transcriptional regulat 96.1 4.6E-05 3.3E-09 75.8 0.0 199 40-300 10-216 (294) 296 4RKQ_B Transcriptional regulat 96.1 4.6E-05 3.3E-09 75.8 0.0 199 40-300 10-216 (294) 297 3LFT_A uncharacterized protein 96.0 5.4E-05 3.9E-09 75.1 0.0 202 45-298 2-209 (295) 298 3LFT_B uncharacterized protein 96.0 5.4E-05 3.9E-09 75.1 0.0 202 45-298 2-209 (295) 299 3HS3_B Ribose operon repressor 95.7 0.00012 8.5E-09 72.0 0.0 195 41-300 6-203 (277) 300 3JVD_A Transcriptional regulat 95.7 0.00012 8.9E-09 74.1 0.0 192 43-299 62-255 (333) 301 3JVD_B Transcriptional regulat 95.7 0.00012 8.9E-09 74.1 0.0 192 43-299 62-255 (333) 302 3S99_A Basic membrane lipoprot 95.7 0.00014 9.8E-09 74.7 0.0 216 27-298 9-229 (356) 303 6DSP_B Autoinducer 2-binding p 95.3 0.00028 2E-08 71.9 0.0 221 38-308 14-250 (347) 304 2FQW_A Membrane lipoprotein tm 95.3 0.0003 2.2E-08 70.6 0.0 146 145-300 61-213 (318) 305 2FQX_A Membrane lipoprotein tm 95.3 0.0003 2.2E-08 70.6 0.0 146 145-300 61-213 (318) 306 2FQY_A Membrane lipoprotein tm 95.3 0.0003 2.2E-08 70.6 0.0 146 145-300 61-213 (318) 307 3H5T_A Transcriptional regulat 95.0 0.00053 3.8E-08 70.4 0.0 146 145-300 127-293 (366) 308 6NDI_A Hypothetical Protein CD 94.9 0.00064 4.6E-08 68.6 0.0 144 145-299 119-269 (334) 309 6NDI_B Hypothetical Protein CD 94.9 0.00064 4.6E-08 68.6 0.0 144 145-299 119-269 (334) 310 4IIL_A Membrane lipoprotein Tp 94.8 0.00072 5.2E-08 68.7 0.0 212 40-299 27-252 (346) 311 6PI6_C Atrazine periplasmic bi 94.8 0.00074 5.3E-08 68.9 0.0 206 38-298 17-227 (355) 312 6PII_A Atrazine periplasmic bi 94.8 0.00074 5.3E-08 68.9 0.0 206 38-298 17-227 (355) 313 6RQG_A 46 kDa surface antigen; 94.7 0.00085 6.1E-08 69.0 0.0 92 145-241 76-195 (387) 314 6RUX_C Surface antigen P46; im 94.7 0.00085 6.1E-08 69.0 0.0 92 145-241 76-195 (387) 315 6S3T_T 46 kDa surface antigen, 94.7 0.00085 6.1E-08 69.0 0.0 92 145-241 76-195 (387) 316 4FE4_A Xylose operon regulator 94.6 0.00092 6.7E-08 69.2 0.0 148 145-300 55-208 (392) 317 4FE7_A Xylose operon regulator 94.4 0.0012 8.7E-08 68.9 0.0 205 38-300 18-228 (412) 318 2HQB_A Transcriptional activat 93.5 0.0031 2.3E-07 62.0 0.0 140 145-298 62-204 (296) 319 6SHU_A Basic membrane protein 93.3 0.0039 2.8E-07 63.5 0.0 205 41-298 43-252 (361) 320 4P98_A Basic membrane lipoprot 91.8 0.01 7.4E-07 58.8 0.0 133 145-283 74-210 (317) 321 4PEV_C solute binding protein; 90.2 0.022 1.6E-06 58.9 0.0 145 145-299 110-271 (422) 322 5ER3_A Sugar ABC transporter, 89.0 0.032 2.3E-06 55.7 0.0 91 145-242 237-332 (341) 323 3QI7_A Putative transcriptiona 87.1 0.055 4E-06 54.7 0.0 152 145-300 86-250 (371) 324 6U1N_R Muscarinic acetylcholin 78.8 0.23 1.6E-05 52.2 0.0 34 644-677 99-133 (509) 325 2Z73_A Rhodopsin; Visual pigme 72.8 0.44 3.2E-05 48.8 0.0 33 645-677 105-138 (448) 326 3AYN_A Rhodopsin; transmembran 72.8 0.44 3.2E-05 48.8 0.0 33 645-677 105-138 (448) 327 6P9X_R Guanine nucleotide-bind 69.6 0.58 4.2E-05 47.7 0.0 27 644-670 177-203 (427) 328 5X33_A LTB4 receptor,Lysozyme, 69.1 0.61 4.4E-05 49.0 0.0 18 644-661 87-104 (523) 329 5XSZ_A Lysophosphatidic acid r 67.4 0.7 5E-05 47.6 0.0 34 644-677 96-130 (477) 330 4PXZ_A P2Y purinoceptor 12, So 67.2 0.71 5.1E-05 47.3 0.0 34 644-677 102-136 (466) 331 6IGK_A Endothelin receptor typ 65.7 0.8 5.8E-05 47.5 0.0 34 644-677 108-142 (498) 332 3ODU_A C-X-C chemokine recepto 65.5 0.8 5.8E-05 47.6 0.0 34 644-677 115-149 (502) 333 5T04_A Neurotensin receptor ty 65.0 0.84 6.1E-05 47.6 0.0 16 645-660 107-122 (513) 334 3ODU_B C-X-C chemokine recepto 65.0 0.84 6.1E-05 47.4 0.0 35 644-678 115-150 (502) 335 3OE0_A C-X-C chemokine recepto 61.9 1 7.6E-05 46.5 0.0 34 644-677 115-149 (499) 336 5T1A_A C-C chemokine receptor 60.9 1.1 8.2E-05 46.5 0.0 34 644-677 119-153 (508) 337 6K41_R Guanine nucleotide-bind 60.4 1.2 8.4E-05 46.6 0.0 34 644-677 280-314 (512) 338 6K42_R Guanine nucleotide-bind 60.4 1.2 8.4E-05 46.6 0.0 34 644-677 280-314 (512) 339 5YC8_A Muscarinic acetylcholin 60.1 1.2 8.6E-05 44.6 0.0 18 644-661 94-111 (421) 340 6N4B_R Guanine nucleotide-bind 59.8 1.2 8.8E-05 46.2 0.0 18 587-604 138-155 (495) 341 3VW7_A Chimera of Proteinase-a 59.5 1.2 9E-05 45.6 0.0 34 644-677 89-123 (484) 342 6GPS_A C-C chemokine receptor 59.5 1.2 9E-05 44.6 0.0 23 644-666 108-130 (429) 343 6ME8_A Soluble cytochrome b562 59.0 1.3 9.3E-05 45.2 0.0 26 644-669 185-210 (460) 344 6ME6_A Soluble cytochrome b562 58.3 1.3 9.7E-05 45.1 0.0 34 644-677 185-219 (460) 345 4GRV_A Neurotensin receptor ty 58.1 1.4 9.8E-05 45.8 0.0 33 645-677 107-140 (510) 346 6WWZ_R Guanine nucleotide-bind 57.9 1.4 0.0001 46.3 0.0 33 644-676 259-292 (529) 347 5ZKC_A Muscarinic acetylcholin 57.5 1.4 0.0001 44.0 0.0 34 644-677 94-128 (421) 348 5IU7_A Adenosine receptor A2a, 57.2 1.4 0.0001 44.2 0.0 17 644-660 82-98 (433) 349 5NM4_A Lysozyme C (E.C.3.2.1.1 57.1 1.4 0.0001 44.2 0.0 17 644-660 82-98 (433) 350 5WIU_A D(4) dopamine receptor, 56.4 1.5 0.00011 43.9 0.0 22 644-665 108-129 (422) 351 5WIV_A D(4) dopamine receptor, 56.4 1.5 0.00011 43.9 0.0 22 644-665 108-129 (422) 352 5NDD_A Lysozyme,Proteinase-act 56.3 1.5 0.00011 46.9 0.0 34 644-677 273-307 (619) 353 4IB4_A Human 5-HT2B receptor_B 56.2 1.5 0.00011 43.9 0.0 34 644-677 99-133 (430) 354 6AK3_A Prostaglandin E2 recept 55.3 1.6 0.00012 43.5 0.0 19 644-662 88-106 (418) 355 6AK3_B Prostaglandin E2 recept 55.3 1.6 0.00012 43.5 0.0 19 644-662 88-106 (418) 356 6M9T_A Prostaglandin E2 recept 54.9 1.7 0.00012 45.6 0.0 17 645-661 139-155 (537) 357 5ZKP_A Platelet-activating fac 54.8 1.7 0.00012 44.2 0.0 34 644-677 88-122 (466) 358 5ZKQ_A Platelet-activating fac 54.6 1.7 0.00012 43.7 0.0 18 644-661 88-105 (438) 359 5W0P_C T4 lysozyme-human rhodo 54.4 1.7 0.00012 49.2 0.0 21 644-664 266-286 (906) 360 5W0P_B T4 lysozyme-human rhodo 54.0 1.8 0.00013 49.1 0.0 23 644-666 266-288 (906) 361 6OSA_R Neurotensin receptor ty 53.5 1.8 0.00013 43.5 0.0 16 645-660 158-173 (435) 362 4U14_A Muscarinic acetylcholin 52.9 1.9 0.00014 43.9 0.0 22 644-665 81-102 (460) 363 5TUD_A Chimera protein of 5-hy 52.5 1.9 0.00014 43.7 0.0 34 644-677 115-149 (457) 364 6C1R_B C5a anaphylatoxin chemo 52.2 2 0.00014 43.1 0.0 34 644-677 191-225 (422) 365 6OL9_A Muscarinic acetylcholin 52.1 2 0.00014 44.0 0.0 16 644-659 81-96 (480) 366 6LI0_A G-protein coupled recep 52.1 2 0.00014 43.8 0.0 34 644-677 95-129 (468) 367 4XES_A neurotensin receptor su 51.2 2.1 0.00015 44.6 0.0 33 645-677 107-140 (541) 368 6C1Q_B C5a anaphylatoxin chemo 51.0 2.1 0.00015 42.9 0.0 34 644-677 191-225 (422) 369 3V2Y_A Sphingosine 1-phosphate 50.5 2.2 0.00016 44.4 0.0 33 645-677 132-165 (520) 370 5UIW_A C-C chemokine receptor 50.3 2.2 0.00016 42.2 0.0 19 644-662 99-117 (411) 371 5OLZ_A Adenosine receptor A2a, 50.0 2.3 0.00016 42.6 0.0 16 645-660 84-99 (434) 372 6P9Y_R Guanine nucleotide-bind 49.7 2.3 0.00017 43.8 0.0 30 645-674 219-248 (483) 373 6MXT_A Fusion protein of Lysoz 49.3 2.4 0.00017 43.4 0.0 34 644-677 237-271 (472) 374 6KUX_A alpha2A adrenergic rece 48.9 2.4 0.00017 41.7 0.0 18 644-661 83-100 (395) 375 4U15_B M3-mT4L, Tiotropium; GP 48.4 2.5 0.00018 42.1 0.0 18 644-661 81-98 (418) 376 3EML_A Human Adenosine A2A rec 48.3 2.5 0.00018 43.3 0.0 15 644-658 88-102 (488) 377 6ORV_RP Guanine nucleotide-bin 48.2 2.5 0.00018 43.6 0.0 34 644-677 231-264 (491) 378 3PBL_A D(3) dopamine receptor; 47.8 2.6 0.00019 43.1 0.0 33 645-677 109-142 (481) 379 6CMO_R Soluble cytochrome b562 47.5 2.6 0.00019 42.9 0.0 34 644-677 246-280 (463) 380 6B3J_R Guanine nucleotide-bind 46.4 2.8 0.0002 43.2 0.0 34 644-677 231-264 (491) 381 4LDE_A Lysozyme, Beta-2 adrene 45.1 3 0.00022 42.4 0.0 33 644-676 251-284 (469) 382 5WF5_A Human A2a adenosine rec 44.9 3.1 0.00022 43.0 0.0 13 645-657 105-117 (504) 383 2R4R_A Beta-2 adrenergic recep 44.8 3.1 0.00022 40.1 0.0 17 644-660 102-118 (365) 384 5TGZ_A Cannabinoid receptor 1, 44.8 3.1 0.00022 42.0 0.0 20 585-604 27-46 (452) 385 3RZE_A Histamine H1 receptor/L 44.7 3.1 0.00022 42.0 0.0 18 644-661 77-94 (452) 386 6MEO_B Envelope glycoprotein g 44.7 3.1 0.00023 39.0 0.0 18 644-661 97-114 (313) 387 4ZUD_A Chimera protein of Solu 44.5 3.1 0.00023 41.1 0.0 22 644-665 192-213 (410) 388 4IAR_A Chimera protein of huma 44.4 3.2 0.00023 40.9 0.0 17 644-660 89-105 (401) 389 6D26_A Prostaglandin D2 recept 44.1 3.2 0.00023 42.0 0.0 33 645-677 102-135 (470) 390 6D27_A Prostaglandin D2 recept 44.1 3.2 0.00023 42.0 0.0 33 645-677 102-135 (470) 391 6A93_A 5-hydroxytryptamine rec 43.8 3.3 0.00024 40.2 0.0 18 644-661 78-95 (376) 392 6A94_A 5-hydroxytryptamine rec 43.8 3.3 0.00024 40.2 0.0 18 644-661 78-95 (376) 393 4IAQ_A 5-hydroxytryptamine rec 43.2 3.4 0.00025 40.6 0.0 18 644-661 89-106 (403) 394 6KPG_R Guanine nucleotide-bind 42.9 3.5 0.00025 41.9 0.0 18 586-603 166-183 (469) 395 4MQS_A Muscarinic acetylcholin 42.4 3.5 0.00026 39.4 0.0 18 644-661 109-126 (351) 396 4DJH_B Kappa-type opioid recep 42.3 3.6 0.00026 41.8 0.0 19 644-662 90-108 (480) 397 6OS0_A Type-1 angiotensin II r 42.3 3.6 0.00026 40.8 0.0 34 644-677 104-138 (425) 398 6OS1_A Type-1 angiotensin II r 42.3 3.6 0.00026 40.8 0.0 34 644-677 104-138 (425) 399 6OS2_A Type-1 angiotensin II r 42.3 3.6 0.00026 40.8 0.0 34 644-677 104-138 (425) 400 4YAY_A human Angiotensin Recep 41.9 3.7 0.00027 40.6 0.0 25 644-668 192-216 (414) 401 4N6H_A Soluble cytochrome b562 41.6 3.7 0.00027 40.6 0.0 34 644-677 193-227 (414) 402 6AKX_B Neuropeptide Y receptor 41.4 3.8 0.00027 39.8 0.0 22 644-665 99-120 (381) 403 6D9H_R Guanine nucleotide-bind 40.8 3.9 0.00028 40.0 0.0 16 645-660 132-147 (389) 404 6RZ4_A Cysteinyl leukotriene r 39.9 4.1 0.0003 40.3 0.0 35 644-678 95-130 (423) 405 6RZ5_B Cysteinyl leukotriene r 39.9 4.1 0.0003 40.3 0.0 35 644-678 95-130 (423) 406 5TVN_A 5-hydroxytryptamine rec 39.9 4.1 0.0003 39.9 0.0 34 644-677 84-118 (402) 407 5UZ7_R Guanine nucleotide-bind 39.5 4.3 0.00031 41.9 0.0 27 645-671 224-250 (501) 408 6I9K_A Kumopsin1; Rhodopsin, G 39.0 4.4 0.00032 39.3 0.0 17 645-661 120-136 (380) 409 4XNV_A P2Y purinoceptor 1, Rub 38.7 4.5 0.00032 40.0 0.0 33 645-677 120-153 (421) 410 4XNW_C P2Y purinoceptor 1, Rub 38.7 4.5 0.00032 40.0 0.0 33 645-677 120-153 (421) 411 5WB1_A Envelope protein US28,n 38.1 4.6 0.00033 40.6 0.0 34 644-677 108-142 (458) 412 6LI1_A G-protein coupled recep 38.1 4.6 0.00033 40.5 0.0 34 644-677 95-129 (449) 413 5UNG_B Soluble cytochrome b562 38.1 4.6 0.00033 39.7 0.0 33 644-676 189-222 (411) 414 5UNF_A Soluble cytochrome b562 37.9 4.7 0.00034 39.7 0.0 25 644-668 189-213 (411) 415 6J21_A Substance-P receptor (E 37.8 4.7 0.00034 40.1 0.0 34 644-677 100-134 (441) 416 5ZHP_A Muscarinic acetylcholin 37.7 4.7 0.00034 39.8 0.0 17 644-660 81-97 (418) 417 5NJ6_A Lysozyme,Proteinase-act 37.6 4.7 0.00034 40.1 0.0 34 644-677 91-125 (437) 418 5DSG_B Muscarinic acetylcholin 37.3 4.8 0.00035 39.8 0.0 17 644-660 82-98 (422) 419 4Z36_A Lysophosphatidic Acid R 37.2 4.9 0.00035 40.6 0.0 34 645-678 136-170 (459) 420 6PT0_R Cannabinoid receptor 2, 37.0 4.9 0.00036 38.7 0.0 12 645-656 103-114 (369) 421 6OIJ_R Guanine nucleotide-bind 36.5 5.1 0.00037 38.4 0.0 34 644-677 103-137 (363) 422 4Z35_A Lysophosphatidic Acid R 36.4 5.1 0.00037 40.5 0.0 14 645-658 136-149 (464) 423 6KR8_A beta 2 adrenergic recep 36.4 5.1 0.00037 37.8 0.0 34 644-677 79-113 (336) 424 6IIU_A Soluble cytochrome b562 36.2 5.2 0.00037 40.6 0.0 24 585-608 136-159 (484) 425 6IIV_A Soluble cytochrome b562 36.2 5.2 0.00037 40.6 0.0 24 585-608 136-159 (484) 426 6E3Y_R Calcitonin gene-related 36.1 5.2 0.00038 41.0 0.0 25 644-668 218-242 (490) 427 6UUN_R Guanine nucleotide-bind 36.1 5.2 0.00038 41.0 0.0 25 644-668 218-242 (490) 428 6M1I_A Ribonuclease 3 (E.C.3.1 35.5 5.4 0.00039 39.5 0.0 28 644-671 184-211 (406) 429 4XT1_A US28, CX3CL1, nanobody 35.4 5.4 0.00039 38.3 0.0 35 644-678 108-143 (362) 430 6LW5_A N-formyl peptide recept 35.2 5.5 0.0004 39.6 0.0 18 645-662 200-217 (427) 431 5VBL_B agonist peptide,Rubredo 34.9 5.6 0.00041 39.0 0.0 34 644-677 116-150 (407) 432 5V54_B OB-1 fused 5-HT1b recep 34.7 5.7 0.00041 38.7 0.0 34 644-677 82-116 (395) 433 5WB2_A Envelope protein US28,n 34.2 5.8 0.00042 39.8 0.0 34 644-677 107-141 (460) 434 6IBB_A Succinate receptor 1, N 33.2 6.2 0.00045 37.3 0.0 34 644-677 94-128 (342) 435 4GBR_A Beta-2 adrenergic recep 33.0 6.3 0.00046 36.4 0.0 17 644-660 74-90 (309) 436 6NBF_R Parathyroid hormone/par 32.2 6.7 0.00048 40.0 0.0 29 646-674 253-281 (478) 437 6NBH_R Parathyroid hormone/par 32.2 6.7 0.00048 40.0 0.0 29 646-674 253-281 (478) 438 6LML_R Guanine nucleotide-bind 31.9 6.8 0.00049 39.1 0.0 34 645-678 195-228 (422) 439 6WHC_R Guanine nucleotide-bind 31.8 6.8 0.00049 39.9 0.0 34 645-678 221-254 (477) 440 6LI2_A G-protein coupled recep 31.7 6.8 0.0005 37.6 0.0 34 644-677 95-129 (372) 441 4L6R_A Soluble cytochrome b562 31.2 7.1 0.00051 39.0 0.0 34 645-678 205-238 (425) 442 6KUW_A Alpha-2C adrenergic rec 31.1 7.1 0.00052 39.7 0.0 17 644-660 92-108 (496) 443 4WW3_A BOG; Animals, Decapodif 30.8 7.2 0.00052 36.9 0.0 17 644-660 96-112 (350) 444 6J20_A Substance-P receptor,En 30.6 7.3 0.00053 38.6 0.0 34 644-677 100-134 (441) 445 5YWY_A Prostaglandin E2 recept 30.6 7.3 0.00053 36.5 0.0 34 644-677 88-122 (332) 446 4JKV_A Soluble cytochrome b562 30.3 7.5 0.00054 39.5 0.0 34 644-677 230-263 (475) 447 4N4W_A Smoothened homolog; Hum 30.3 7.5 0.00054 39.5 0.0 34 644-677 230-263 (475) 448 6FJ3_A Parathyroid hormone/par 30.2 7.5 0.00054 41.0 0.0 33 646-678 214-246 (602) 449 5ZBH_A Neuropeptide Y receptor 29.8 7.7 0.00056 39.8 0.0 17 644-660 118-134 (527) 450 6NIY_R Adenosine receptor A1,S 29.6 7.9 0.00057 39.3 0.0 27 645-671 216-242 (474) 451 5XJM_A Type-2 angiotensin II r 29.0 8.1 0.00059 37.9 0.0 34 644-677 80-114 (422) 452 6VMS_R Guanine nucleotide-bind 28.9 8.2 0.00059 38.6 0.0 16 645-660 245-260 (450) 453 6PS2_A Fusion protein of Beta- 28.3 8.5 0.00062 39.4 0.0 34 644-677 126-160 (506) 454 6PB0_R Corticotropin-releasing 28.3 8.6 0.00062 37.3 0.0 28 644-671 161-188 (375) 455 3PDS_A Fusion protein Beta-2 a 28.1 8.7 0.00063 38.5 0.0 33 645-677 79-112 (458) 456 5UEN_B Adenosine receptor A1,S 27.5 9 0.00065 37.5 0.0 16 645-660 78-93 (416) 457 5ZBQ_A Neuropeptide Y Y1 recep 27.3 9.1 0.00066 39.2 0.0 20 644-663 108-127 (525) 458 6RNK_A Succinate receptor 1, N 27.3 9.1 0.00066 36.0 0.0 34 644-677 94-128 (342) 459 5UEN_A Adenosine receptor A1,S 27.1 9.2 0.00067 37.4 0.0 16 645-660 78-93 (416) 460 6PB1_P Corticotropin-releasing 26.9 9.4 0.00068 37.3 0.0 33 644-676 179-211 (387) 461 6OMM_R N-formyl peptide recept 26.6 9.6 0.0007 36.2 0.0 16 645-660 116-131 (363) 462 5N2S_A Adenosine receptor A2a, 26.3 9.8 0.00071 37.6 0.0 15 645-659 184-198 (436) 463 5LWE_A C-C chemokine receptor 25.1 11 0.00077 35.3 0.0 20 644-663 93-112 (331) 464 5ZTY_A G protein coupled recep 24.4 11 0.00081 38.3 0.0 20 585-604 37-56 (500) 465 2KSA_A Substance-P receptor, S 23.6 12 0.00086 35.5 0.0 16 645-660 102-117 (364) 466 5LWE_B C-C chemokine receptor 23.4 12 0.00087 34.9 0.0 18 644-661 93-110 (331) 467 5DHG_B Nociceptin receptor-Cyt 23.4 12 0.00087 36.7 0.0 34 644-677 193-227 (424) 468 5DHH_B GPCR-BRIL Chimera; Noci 23.4 12 0.00087 36.7 0.0 34 644-677 193-227 (424) 469 4DKL_A Mu-type opioid receptor 20.3 15 0.0011 36.5 0.0 17 644-660 85-101 (464) 470 5NX2_A Glucagon-like peptide 1 20.1 16 0.0011 36.1 0.0 33 645-677 204-236 (422) 471 6LN2_A Glucagon-like peptide 1 20.1 16 0.0011 36.9 0.0 35 644-678 199-233 (469) No 1 >6N4X_A Metabotropic glutamate receptor 5; Cell Surface Receptor, MEMBRANE PROTEIN; HET: NAG; 4.0A {Homo sapiens} Probab=100.00 E-value=2.5e-77 Score=724.04 Aligned_cols=801 Identities=44% Similarity=0.813 Sum_probs=331.4 Template_Neff=10.300 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDT 110 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~ 110 (908) ........+++++||+++|.++... ....|+......+....+|+++|++++|+++++++|+++++.+.|+++++. T Consensus 30 ~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~C~~~~~~~g~~~~~a~~~Av~~iN~~~~~lp~~~l~~~i~Dt~~~~~ 109 (877) T 6N4X_A 30 ERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSA 109 (877) T ss_dssp CCCCCEEECCSEEEEEEECCBCCCCSGGGTTTCCCSBCCCCCCCHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTSHH T ss_pred CceEEEEeCCCEEEEEEEecccCCCcccccccCccchhhccCHHHHHHHHHHHHHHhcCCCCCCCCeeeeEEecCCCCHH Confidence 3444567889999999999987421 124566444445677899999999999998888889999999999998866 Q NP_000836.2 111 YALEQSLTFVQALIEK---DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNT 187 (908) Q Consensus 111 ~a~~~~~~~~~~l~~~---~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~ 187 (908) .+.+.+.+++.+.... ......|...++.+....+++++++|+.++..+..++.++...++|++++.++++.++++. T Consensus 110 ~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~a~~~~~~~ip~is~~~~s~~ls~~~ 189 (877) T 6N4X_A 110 VALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKT 189 (877) T ss_dssp HHHHHHHHHHHHHHHC--------------------CCCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTT T ss_pred HHHHHHHHHHHhhcCCccccccceeccCCCCcccCCCCCeEEEECCCCcHHHHHHHHHHHHhCCCeEeecCCCcccCCcc Confidence 5555544443321000 0000000000000001124788999998888878888899999999999988877776655 Q NP_000836.2 188 RYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 188 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .+++++++.|++..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....+..+....++...++ T Consensus 190 ~~p~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-gi~i~~~~~~~~~~~~~~~~~~l~ 268 (877) T 6N4X_A 190 LFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLK 268 (877) T ss_dssp TSTTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEECTTTTHHHHHHHHHHHHHHH-TCEEEEEEECCSSCCSSHHHHHHH T ss_pred ccCccccCCCCHHHHHHHHHHHHHHcCCcEEEEEEeCCcchHHHHHHHHHHHHHc-CcEEEEEEEecccCChHHHHHHHH Confidence 6899999999999999999999999999999999987788888888888888775 466543322221112234556666 Q NP_000836.2 268 RLLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFR 346 (908) Q Consensus 268 ~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~ 346 (908) ++++ ..++++|++......+..+++++++.|+.+++.|++.+.|...............+.+.+.......+.|..++. T Consensus 269 ~l~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~~ 348 (877) T 6N4X_A 269 KLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYL 348 (877) T ss_dssp HHHTTTTTCCEEEEECCHHHHHHHHHHHHHTTCSSCSEEEECGGGSSCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHT T ss_pred HHHhcCCCceEEEEECChhhHHHHHHHHHHhCCCCcEEEEEecccccCccccCCcccccccceeeeeeCCCCCcHHHHHH Confidence 6653 126677777766667888999998888754456777665543221100011122333333322222333433332 Q NP_000836.2 347 SRTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 347 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ...+.....+.++.++|++.+++........ ..+...|+....... ......++.++|||++++++|++++....+. T Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDAv~~~a~al~~~~~~~~~ 426 (877) T 6N4X_A 349 KLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCP 426 (877) T ss_dssp TCCTTTCCSSTTHHHHHHHHTTCCCTTSTTCCSSCCSCCCTTCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHSS T ss_pred hcCcccCCCChHHHHHHHHHcCCcCCCCCccccCCccccCCcceecc--cccccchHHHHHHHHHHHHHHHHHHHhccCC Confidence 2211112234566777776655432110000 001112322211100 0112346778999999999999998764332 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDM 502 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i 502 (908) .....|......++..+.+.+++.+|+|.+| + ++||++|++...+.+.+++..+ +...++.||.|+... .++ ..+ T Consensus 427 ~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~Fd~~G~~~~~~~I~~~~~~~~~~~~~~~Vg~~~~~~l~~~-~~~ 504 (877) T 6N4X_A 427 GYAGLCDAMKPIDGRKLLESLMKTNFTGVSG-DTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDE 504 (877) T ss_dssp SCSSCCSSSSSCCHHHHHHHHHHCEEECTTS-CEEECCTTSCCCCEEEEEEEEECSSSCEEEEEEEEEETTEEEEC-HHH T ss_pred CCCCCccccCCCCHHHHHHHHhcCeeecCCC-CEEEeCCCCCCCceeEEEEEEEeCCCeEEEEEEEEEeCCceEec-ccc Confidence 2112232212234556778888889999988 6 9999999998889999987532 123578999998652 121 246 Q NP_000836.2 503 QWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHS 581 (908) Q Consensus 503 ~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~ 581 (908) .|.+ +...|.+.|+++|++|+++...++ +.|||.|.+|+.++++++..+|..||.+.||+++++.|...+..+..++. T Consensus 505 ~w~~-~~~~p~s~c~~~C~~G~~~~~~~~~~~cc~~c~~C~~~~~~~~~~~c~~c~~~~~~~~~~~~c~~~~~~~~~~~~ 583 (877) T 6N4X_A 505 VWSK-KSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGD 583 (877) T ss_dssp HSSS-SSSSCCCCSSCCCCSSSCCCCCCSSCSSCCCCCCCCSSSCCCSSSCC---------------------------- T ss_pred cccc-CCCcceeecCCCCCCCeeEeeeCCcceeceeEecCCCCeEeCCCcccccCCCCeeeCCCCCCCeeccceeccCCC Confidence 7865 346689999999999998877666 68999999999999998889999999999999999999887788888999 Q NP_000836.2 582 PWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCF 661 (908) Q Consensus 582 ~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~~~~~~gf~l 661 (908) ++.+++.++++++++++++++++++++|+++.+|++++.|+.++|+|++++|++++++++.|+...|.+|.|++++||++ T Consensus 584 ~~~i~~~~~~~~~i~~~~~~~~~~~~~r~~~~ik~~~~~~~~~~l~g~~l~~~~~~~~~~~~~~~~C~~~~~~~~l~f~l 663 (877) T 6N4X_A 584 PEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAM 663 (877) T ss_dssp -------------------------------------------------------------------------------- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHccCCchhhcCCHHHHHHHHHHHHHHHHHHHHHccCcchhhHHHHHhHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 662 SYAALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGV 739 (908) Q Consensus 662 ~~~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~ 739 (908) +||+|++|+||++++|.+++.++ ++.++++++.+++++++++++++++++.|+.++|+........ ..... T Consensus 664 ~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~-------~~~~~ 736 (877) T 6N4X_A 664 SYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS-------IREVY 736 (877) T ss_dssp -------------------------------------------------------------------------------- T ss_pred HHHHHHHHHHHHHHHHhcCCCCCCCCCCccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCcccCCCc-------CceEE Confidence 99999999999999998765421 1123567777888888899999999999999999876543211 12345 Q NP_000836.2 740 LKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLT 819 (908) Q Consensus 740 ~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 819 (908) ..|.+.+.+++++++|+++|++++++|||++|++|++|||+|+|++++|+++++|++++++++..... +.+.+ T Consensus 737 ~~C~~~~~~~~~~~~y~~~ll~~~~~la~~~R~~~~~~ne~~~i~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~~ 809 (877) T 6N4X_A 737 LICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK-------IITMC 809 (877) T ss_dssp -------------------------------------------------------------------------------- T ss_pred EEccCCCHHhHHHHHHHHHHHHHHHHHHHHhcCCCccccHHHHHHHHHHHHHHHHHHHHHHHHcCCch-------HHHHH Confidence 78998766677899999999999999999999999999999999999999999999999998654322 23666 Q NP_000836.2 820 VSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRS 855 (908) Q Consensus 820 ~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 855 (908) ++++++++++|+++|+||+|.++++|+++.+.+.+. T Consensus 810 ~~~~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 845 (877) T 6N4X_A 810 FSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTT 845 (877) T ss_dssp ------------------------------------ T ss_pred HHHHHHHHHHHHHHHhhhhhHHHhCcccchhhhhee Confidence 788899999999999999999999999988765333 No 2 >6N52_B Metabotropic glutamate receptor 5; Cell Surface Receptor, MEMBRANE PROTEIN; HET: NAG; 4.0A {Homo sapiens} Probab=100.00 E-value=1.2e-76 Score=718.13 Aligned_cols=803 Identities=44% Similarity=0.810 Sum_probs=569.0 Template_Neff=10.400 Q NP_000836.2 34 QEYAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 34 ~~~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) ++.......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++.+.|+++++ T Consensus 29 ~~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~C~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~i~Dt~~~~ 108 (871) T 6N52_B 29 SERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHS 108 (871) T ss_dssp ---CCCEEECCSEEEEEEECCBCCCCGGGTTTTCCCSBCCCCCCHHHHHHHHHHHHHHSCTTSSTTCCEEEEEEECTTSH T ss_pred CCceEEEEeCCCEEEEEEEeeccCCCcccccccccccccccccHHHHHHHHHHHHHHhcCCCCCCCCeeccEEecCCCCH Confidence 34445578899999999999987521 13467654444567788999999999999888888999999999999886 Q NP_000836.2 110 TYALEQSLTFVQALIEK---DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~---~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) ..+.+.+.+++.+.... ......|...++.+....+++++++|+.++..+.+++.++...++|++++.++++.++++ T Consensus 109 ~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~a~~~~~~~ip~is~~~~s~~l~~~ 188 (871) T 6N52_B 109 AVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDK 188 (871) T ss_dssp HHHHHHHHHHHHHHHHHHHC-------------CCCCCCCEEEEECCSCHHHHHHHHHHHGGGTCCEEESSCCCGGGGCT T ss_pred HHHHHHHHHHHHhccCCCcccccceeccCCCcccccCCCCeEEEECCCCcHHHHHHHHHHHHhCCCEEeeccCCcccCCc Confidence 65555544443321000 000000000000000112478899999888877788889999999999998877777665 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.|++..+++++++++++++|+++++++++++++....+.+++.+++. ++++.....+..+.+..++...+ T Consensus 189 ~~~p~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-gi~i~~~~~~~~~~~~~~~~~~~ 267 (871) T 6N52_B 189 TLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLL 267 (871) T ss_dssp TTCTTEEESSCCSHHHHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHTTT-TCEECCCCEECTTCCHHHHHHHH T ss_pred cccCcccCCCCCHHHHHHHHHHHHHHcCCcEEEEEEeCCcchHHHHHHHHHHHHHc-CcEEEEEEEEccCCChHHHHHHH Confidence 56899999999999999999999999999999999987778888888888888775 46654332222111223455666 Q NP_000836.2 267 KRLLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++++ ..+.+++++......+..+++++++.|+.+++.|++.+.|...............+.+.+.......+.|..++ T Consensus 268 ~~l~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~f~~~~ 347 (871) T 6N52_B 268 KKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYY 347 (871) T ss_dssp HHHHTTTTTCCEEEEESCHHHHHHHHHHHHHHTCTTTCEEEECGGGSSCTTTTTTCTTTSTTCEEEEECCCCCHHHHHHH T ss_pred HHHHhcCCCceEEEEECChhhHHHHHHHHHHhCCCCcEEEEEecccccCccccCCchhhcccceeeeecCCCCCcHHHHH Confidence 66652 12667777766666778899999888876445677766554322110001112233333332222233333333 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ....+...+.+.++.++|++.+++........ ..+...|+..+.... ......++.++|||++++++|++++....+ T Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDAv~~~a~al~~~~~~~~ 425 (871) T 6N52_B 348 LKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLC 425 (871) T ss_dssp HTCCTTTCCSSTTHHHHHHHHSCEECTTSTTCCTTCCEECCTTCCSCT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHS T ss_pred HhcCcccCCCChHHHHHHHHHcCCCCCCCCcccccCcccCCCcccccc--ccccchhHHHHHHHHHHHHHHHHHHHhhcC Confidence 22211122334566777776655432110000 001122332221110 012234677899999999999999876443 Q NP_000836.2 425 PGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVED 501 (908) Q Consensus 425 ~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~ 501 (908) ......|......++..+.+.+++.+|.|.+| + ++||++|++...+.+.+++..+ +...++.||.|+... .++ .. T Consensus 426 ~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~l~~~-~~ 503 (871) T 6N52_B 426 PGYAGLCDAMKPIDGRKLLESLMKTNFTGVSG-DTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DD 503 (871) T ss_dssp TTCSSCCGGGSSCCSHHHHHHHHTCEEECTTC-CEEECCTTCBCCCEEEEEEEECCSSSCCEEEEEEEEETTEEEEC-TT T ss_pred CCCCCCCcccCCCCHHHHHHHHhcCceecCCC-CEEEeCCCCCCCcceEEEEEEEeCCCeEEEEEEEEEeCCceEec-cc Confidence 22112232222234556778888889999988 6 9999999998889999887532 123578999998652 122 24 Q NP_000836.2 502 MQWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 502 i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +.|.+ +...|.+.|+.+|++|+++...++ +.|||.|.+|+.++++++..+|..||.+.||+++++.|...+..+..++ T Consensus 504 ~~w~~-~~~~p~s~cs~~C~~G~~~~~~~~~~~cc~~c~~C~~~~~~~~~~~c~~c~~~~~~~~~~~~c~~~~~~~~~~~ 582 (871) T 6N52_B 504 EVWSK-KSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWG 582 (871) T ss_dssp TSSSS-SCCSCCCCSSCCCCTTTEECCBCSSCSSCBCCEECCTTEEECSSSCEEECCTTEECCTTSSSCEECCCCCCCSS T ss_pred hhccc-CCCCceeeecCCCCCCeeEeccCCCCeeccCcccCCCCeEeCCCcccccCCCCeecCCCCCCceecceeeccCC Confidence 67865 346689999999999999887767 6899999999999999988999999999999999999988777888889 Q NP_000836.2 581 SPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC 660 (908) Q Consensus 581 ~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~~~~~~gf~ 660 (908) .++.+++.++++++++++++++++++++|+++++|++++.+++++|+|++++|++++++++.|+...|.+|.|++++||+ T Consensus 583 ~~~~i~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~~~~~~~~~~l~g~~~~~~~~~~~~~~~~~~~C~~~~~~~~~gf~ 662 (871) T 6N52_B 583 DPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPA 662 (871) T ss_dssp CHHHHHHHHHHHHHHHHHHHHTTTTTTTTTCHHHHSSCTTHHHHHHHHHHHHHHHHHHHSSCCCTTHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHccCCCcccCCCHHHHHHHHHHHHHHHHHHHHHccCcchhHHHHHHhHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 661 FSYAALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARG 738 (908) Q Consensus 661 l~~~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~~~~~~~~~ 738 (908) ++||+|++|+||++++|++.+.++ +..++++.+.+++++++++++++++++.|+.++|+........ .... T Consensus 663 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~i~~~~~~~~p~~~~~~~~~-------~~~~ 735 (871) T 6N52_B 663 MSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS-------IREV 735 (871) T ss_dssp HHHHHHHHHHHTCC--------------------CCHHHHHHHHHHHHHHHHHHHHHHSCCCEECCCSS-------SSCC T ss_pred HHHHHHHHHHHHHHHHHHcCCCCCCCCCCccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCcccCCCC-------CceE Confidence 999999999999999998765421 1123566777888888899999999999999999876533211 1234 Q NP_000836.2 739 VLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTL 818 (908) Q Consensus 739 ~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 818 (908) ...|.+.+.+++++++|.++|++++++|||++|++|++|||+|+|++++|+++++|++++++++..... +.+. T Consensus 736 ~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nE~k~i~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~ 808 (871) T 6N52_B 736 YLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK-------IITM 808 (871) T ss_dssp CCEECCCHHHHHHHHHHHHHHHHHHHHHHHHSTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCT-------THHH T ss_pred EEEccCCcHHhHHHHHHHHHHHHHHHHHHHHhcCCCccccHHHHHHHHHHHHHHHHHHHHHHHhCCCch-------HHHH Confidence 678998766677899999999999999999999999999999999999999999999999998755322 2366 Q NP_000836.2 819 TVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF 856 (908) Q Consensus 819 ~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~~ 856 (908) ++.++++++++|+++|+||+|.++++|+++.+++.+.+ T Consensus 809 ~~~~~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~~ 846 (871) T 6N52_B 809 CFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS 846 (871) T ss_dssp HHHHHHHHHHHHHTTTTTTSCCCCCSGGGC-------- T ss_pred HHHHHHHHHHHHHHHHhhhhhhhhhCcccchhhhheec Confidence 67888999999999999999999999998887664443 No 3 >6N51_B Metabotropic glutamate receptor 5, Nanobody; Cell Surface Receptor, MEMBRANE PROTEIN; HET: NAG, QUS; 4.0A {Homo sapiens} Probab=100.00 E-value=6.7e-76 Score=706.52 Aligned_cols=786 Identities=44% Similarity=0.821 Sum_probs=571.7 Template_Neff=10.700 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYA 112 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a 112 (908) ......+++++||+++|.|+... ....|+......+.+...|+++|++++|+++++++|+++++++.|+++++..+ T Consensus 4 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~c~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~Dt~~~~~~a 83 (804) T 6N51_B 4 RVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVA 83 (804) T ss_pred cceeEecCCEEEEeEeeccCCCCCCCCCCCCcccccCcccHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEeCCCCHHHH Confidence 34467788999999999987532 13467754445667789999999999999888888999999999998876555 Q NP_000836.2 113 LEQSLTFVQALIEK---DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 113 ~~~~~~~~~~l~~~---~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) .+.+.+++.+.... ......+...++.+...++++++++|+.++..+..++.+++..++|++++.+.++.++++..+ T Consensus 84 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~a~~~~~~~ip~is~~~~~~~l~~~~~~ 163 (804) T 6N51_B 84 LEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLF 163 (804) T ss_pred HHHHHHHHccCCCCCcccCCceecCCCCccccccCCCceEEEcCCChHHHHHHHHHHHHhCCCccccccCCcccCCcccC Confidence 44444443210000 000000000000000112578899999888877788889999999999998877776655568 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) ++++++.|++..++.++++++++++|+++++++++++++....+.+++.+++. ++++.....+..+.+..++.+.++++ T Consensus 164 ~~~~r~~ps~~~~~~al~~~l~~~~w~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~~~~~~~~~~~~~~l 242 (804) T 6N51_B 164 KYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLKKL 242 (804) T ss_pred CcccccCCCHHHHHHHHHHHHHHhCCcEEEEEEecChhhHHHHHHHHHHHHHc-CcEEEEEEEeCCCCCccchHHHHHHH Confidence 99999999999999999999988999999999988788888888888888775 46654332222111223455666666 Q NP_000836.2 270 LE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSR 348 (908) Q Consensus 270 ~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~ 348 (908) ++ ..+.+++++......+..+++++++.|+.+++.|++.+.|...............+.+.+.........|..++... T Consensus 243 ~~~~~~~~vvv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~~~~ 322 (804) T 6N51_B 243 TSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKL 322 (804) T ss_pred HhcCCCcEEEEEECCHHHHHHHHHHHHHhCCCCCeEEEEeccccCCCCccccchhhhceEEEEeccCCCCCCHHHHHHhC Confidence 53 12567777666666778899999988876445677665544321110001112223333322222222333332221 Q NP_000836.2 349 TLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY 427 (908) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~ 427 (908) .+.....+.++.++|++.+++........ ..+...|+..+.... ......++.++|||++++++|++++..+.+... T Consensus 323 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDAv~~~a~al~~~~~~~~~~~ 400 (804) T 6N51_B 323 RPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGY 400 (804) T ss_pred CCCCCCCChHHHHHHHHHcCCCCCCCCCCCCcCCccCCCCccccc--CCCcchhHHHHHHHHHHHHHHHHHHHhccCCCC Confidence 11112234566677766655432110000 001123332221110 012334677899999999999999876443221 Q NP_000836.2 428 IGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDMQW 504 (908) Q Consensus 428 ~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i~w 504 (908) ...|......++..+.+.+++.+|.|.+| . +.||++|++...+.+.+++..+ +...++.||.|+... .++ ..+.| T Consensus 401 ~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~l~~~-~~~~w 478 (804) T 6N51_B 401 AGLCDAMKPIDGRKLLESLMKTNFTGVSG-DTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDEVW 478 (804) T ss_pred CCCCcccCCCCHHHHHHHHhheeeecCCC-CEEEECCCCCcCCeeEEEEEEECCCCcEEEEEEEEEcCCceEEe-ceeec Confidence 12222212234556778888889999988 6 9999999998889999988532 223578999998652 222 24678 Q NP_000836.2 505 AHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPW 583 (908) Q Consensus 505 ~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~ 583 (908) ..+ ...|.+.|+.+|++|+++...++ +.|||.|.+|+.++++++..+|..||.+++|+++++.|...+..+..+++++ T Consensus 479 ~~~-~~~p~s~cs~~C~~g~~~~~~~~~~~cc~~c~~C~~~~~~~~~~~c~~c~~~~~~~~~~t~c~~~~~~~~~~~~~~ 557 (804) T 6N51_B 479 SKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPE 557 (804) T ss_pred CCC-CCCCCccccCCCCCCceecCCCCCCccceeeeeCCCCcccCCCcceecCCCCCcCCCCCCceeeccchhcCCCcHH Confidence 652 46689999999999998877666 7899999999999999888999999999999999999988888888999999 Q NP_000836.2 584 AVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSY 663 (908) Q Consensus 584 ~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~~~~~~gf~l~~ 663 (908) .+++.++++++++++++++++++++|+++.+|++++.+++++|+|++++|++++++++.|+...|.+|.|++++||+++| T Consensus 558 ~i~~~~~~~~~i~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~l~g~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~l~~ 637 (804) T 6N51_B 558 PIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSY 637 (804) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHCCCCcccccCCHHHHHHHHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 664 AALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLK 741 (908) Q Consensus 664 ~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~~ 741 (908) |+|++|+||++++|++++.++ +..++++.+.+++++++++++|+++++.|+.++|+........ ....+.. T Consensus 638 ~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~-------~~~~~~~ 710 (804) T 6N51_B 638 SALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS-------IREVYLI 710 (804) T ss_pred HHHHHHHHHHHHHHhcCCCCCCCCccccCCHHHHHHHHHHHHHHHHHHHHHHHHhCCCCCCCCCCC-------CCcEEEE Confidence 999999999999998765321 1123456677777888889999999999999999876543211 1234668 Q NP_000836.2 742 CDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVS 821 (908) Q Consensus 742 C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 821 (908) |...+.+++++++|.++|++++++|||++|++|++|||+|+|++++|+++++|++++++++..... +.+.+++ T Consensus 711 C~~~~~~~~~~~~~~~~ll~~~~~la~~~r~~~~~~~e~~~i~~~~~~~~~~~~~~~~~~~~~~~~-------~~~~~~~ 783 (804) T 6N51_B 711 CNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK-------IITMCFS 783 (804) T ss_pred cCCCcHHHHHHHHHHHHHHHHHHHHHHHhCCCCccccHHHHHHHHHHHHHHHHHHHHHHHhCCCch-------HHHHHHH Confidence 998766677899999999999999999999999999999999999999999999999998765322 2366788 Q NP_000836.2 822 MSLSASVSLGMLYMPKVYIII 842 (908) Q Consensus 822 i~~~~~~~l~~~f~PK~~~i~ 842 (908) ++++++++|+++|+||+|.|+ T Consensus 784 ~~~~~~~~l~~~f~Pk~~~i~ 804 (804) T 6N51_B 784 VSLSATVALGCMFVPKVYIIL 804 (804) T ss_pred HHHHHHHHHHHHHHhhhhhcC Confidence 899999999999999999874 No 4 >6W2Y_A Gamma-aminobutyric acid type B receptor; Inhibitor, Homodimer, GPCR, SIGNALING PROTEIN; HET: SGG, L9Q, NAG; 3.2A {Homo sapiens} Probab=100.00 E-value=3.8e-66 Score=620.75 Aligned_cols=685 Identities=21% Similarity=0.299 Sum_probs=472.4 Template_Neff=10.100 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQ 115 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~ 115 (908) .......+++++||+++|.++.. ..+.....|+++|++++|+++++++|+++++.+.|+++++..+.+. T Consensus 22 ~~~~~~~~~~i~IG~l~p~~~~~-----------~~g~~~~~a~~~Av~~iN~~~~il~g~~l~l~~~Dt~~~~~~a~~~ 90 (829) T 6W2Y_A 22 PPHPSSERRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKY 90 (829) T ss_dssp ------CCEEEEEEEEECSSSSC-----------CCSTTTHHHHHHHHHHHHHCTTTSTTEEEEEEEEECTTCHHHHHHH T ss_pred CCCCCCCCceEEEEEEEecCCCC-----------CCcchHHHHHHHHHHHHHhCCCCCCCcEEEEEEecCCCCHHHHHHH Confidence 34455677899999999998642 1356778999999999999888888999999999998876544433 Q NP_000836.2 116 SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 116 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) +.+++. .+++++++|+.++..+..++.+++.+++|+|+++++++.++++..+++++|+ T Consensus 91 ~~~l~~----------------------~~~v~~viG~~~s~~~~~va~~~~~~~ip~is~~a~s~~ls~~~~~p~~frt 148 (829) T 6W2Y_A 91 LYELLY----------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRT 148 (829) T ss_dssp HHHTTS----------------------SSSCEEEEEECSHHHHHHHHHTTTTTTCEEEESSCCCGGGGCTTTCTTEEES T ss_pred HHHHHh----------------------cCCcEEEEECCChHHHHHHHHHHHHcCCEEEecccCChhHhccccCCceEEc Confidence 333322 1478899999888888888899999999999999888887776678999999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) .|++..++.++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++ T Consensus 149 ~ps~~~~~~a~~~ll~~~~w~~vaii~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~-----~d~~~~~~~l~~-~~~ 221 (829) T 6W2Y_A 149 HPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDA 221 (829) T ss_dssp SCCSGGGHHHHHHHHHHHCCCEEEEEECCSTTHHHHHHHHHHHHHTT-TCEEEEEEECS-----SCCHHHHHHHHH-TTC T ss_pred CCChhhccHHHHHHHHHhCCeEEEEEEeCCcccchhHHHHHHHHHHc-CCEEEEEEccc-----CCchHHHHHHhh-CCC Confidence 99999999999999999999999999988888888888888888775 47765443332 134455667763 578 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSD----SWGSKIAPV-----YQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~----~~~~~~~~~-----~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++|++......+..+++++++.|+.+ ++.|+..+ .|....... .......+|.+....... T Consensus 222 riIv~~~~~~~~~~~l~~a~~~g~~~~~~vwi~~~~~~~~w~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~--------- 292 (829) T 6W2Y_A 222 RIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVML--------- 292 (829) T ss_dssp SEEEEECCHHHHHHHHHHHTTTTCCSTTCEEEEESCSCSSCTTSCCTTCCSCHHHHHTTTTTCEEEEECCS--------- T ss_pred EEEEEeCCHHHHHHHHHHHHHccccCCCeEEEEeccccccchhccCCCCCCCHHHHHHHHcccEEEEEecc--------- Confidence 99988877777888999998888764 56777653 222110000 001112233322211000 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ... ......+.++.++++++..+ .... + . ......++..+|||++++++|++++....+. T Consensus 293 ~~~-~~~~~~~~~~~~f~~~~~~~-~~~~---~----~-----------~~~~~~~a~~~YDAv~~~a~Al~~~~~~~~~ 352 (829) T 6W2Y_A 293 NPA-NTRSISNMTSQEFVEKLTKR-LKRH---P----E-----------ETGGFQEAPLAYDAIWALALALNKTSGGGGR 352 (829) T ss_dssp CCS-CCCCTTSCCHHHHHHHHHTT-CSSC---T----T-----------TSTTSSSHHHHHHHHHHHHHHHHHHC----- T ss_pred CCC-CCCCcCCCCHHHHHHHHHHH-HhcC---C----c-----------cCCCCccccHHHHHHHHHHHHHHHHhhcCcc Confidence 000 00000122233333322111 1000 0 0 0112345778999999999999998754321 Q NP_000836.2 426 GYIGLCPR----MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVED 501 (908) Q Consensus 426 ~~~~~~~~----~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~ 501 (908) . +.+.. .....++.+.++|++.+|.|.+| ++.||++|++...+.+.+++ ++.++.||.|+.... . T Consensus 353 ~--~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~tG-~v~fd~~G~r~~~~~i~~~~----~~~~~~vg~~~~~~~----~ 421 (829) T 6W2Y_A 353 S--GVRLEDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDSTKD----D 421 (829) T ss_dssp -----CCTTCCTTCTTHHHHHHHHHHTCEEEETTE-EEEBCTTSCBCCEEEEEEES----SSSEEEEEEEETTTC----C T ss_pred C--CCCHHHcCCCChHHHHHHHHHHHcCcccccee-eEEeCCCCCccceEEEEEee----CCeEEEEEEEECCCC----C Confidence 1 10100 01123446778888889999988 89999999998888888887 357899999986531 2 Q NP_000836.2 502 MQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHS 581 (908) Q Consensus 502 i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~ 581 (908) +.|... ..|+.|. +|.| ++.| ...+..++. T Consensus 422 l~~~~~----------~~w~~g~-------------------------------~p~d------~~~~---~~~~~~~s~ 451 (829) T 6W2Y_A 422 LSWSKT----------DKWIGGS-------------------------------PPAD------QTLV---IKTFRFLSQ 451 (829) T ss_dssp CBCCSC----------CCCSSSS-------------------------------CCCS------SCCE---EEEECCCCS T ss_pred ceecCC----------CccCCCC-------------------------------CCCC------Ccee---ceeecccCH Confidence 344221 1222221 2434 4444 334455667 Q NP_000836.2 582 PWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFL------MIAAP-DTIICSFRRVF 654 (908) Q Consensus 582 ~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~------~~~~~-~~~~C~~~~~~ 654 (908) ++.+++.++++++++++++++++++++|+++.+|+++|.+++++|+|++++|+++++ ++..+ +...|.+|.|+ T Consensus 452 ~~~i~~~~~~~~gi~~~~~~~~~~~~~r~~~~ik~s~~~l~~~~l~G~~l~~~~~~~~~~~~~~i~~~~~~~~C~~~~~~ 531 (829) T 6W2Y_A 452 KLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWL 531 (829) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHSCSSSHHHHHSCHHHHHHHHHHHHHHHHTTTTTTCSSSSCCTTTHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHcccChhhhCCCHHHHHHHHHHHHHHHHHHHHhcCCccCCCcccccHHHHHHHHH Confidence 788888999999999999999999999999999999999999999999999999986 34444 68999999999 Q NP_000836.2 655 LGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT---- 730 (908) Q Consensus 655 ~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~---- 730 (908) +++||+++||+|++|+||++++|++++.++.+++.++++.++.++++++++|++++++|++++|+..........+ T Consensus 532 ~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~l~~i~~iil~~w~~~~p~~~~~~~~~~~~~~~~ 611 (829) T 6W2Y_A 532 LGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKED 611 (829) T ss_dssp HHHHHHHHHHHHHHHHHHHHHTC---------------CCHHHHHHHHHHHHHHHHHHHHHHSCCCEEEEECCCCCC--- T ss_pred HHHHHHHHHHHhhhhceEEEEEeecccccchhhccCCHHHHHHHHHHHHHHHHHHHHHHHHHCcccceeeecccCCCCcc Confidence 9999999999999999999999997765322245678899999999999999999999999999986543211000 Q NP_000836.2 731 LDPEKARGVLKCDISD--LSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807 (908) Q Consensus 731 ~~~~~~~~~~~C~~~~--~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~ 807 (908) .+....+..+.|.+.+ .|++++++|+++|+++|++|||++|+++ ++|||+|+|++++|+++++|+++++++++.... T Consensus 612 ~~~~~~~~~~~C~~~~~~~~~~~~~~y~~lll~~~~~la~~tR~~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~ 691 (829) T 6W2Y_A 612 IDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQ 691 (829) T ss_dssp -CCEEEEEEEEECCSSHHHHHHHHHHHHHHHHHHHHHHHHHTCC------CCCSTHHHHHHHHHHHHHHHHHHHHHGGGC T ss_pred CCceeeceEEeecCCCcHHHHHHHHHHHHHHHHHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHHHHHHHHHHHhcCc Confidence 0000123367999864 7888999999999999999999999999 899999999999999999999999998766543 Q NP_000836.2 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRK 853 (908) Q Consensus 808 ~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~ 853 (908) + ...+.+.+++++++++++|+++|+||+|.++++++.+.+... T Consensus 692 ~---~~~~~~~~~~i~~~~~~~l~~~f~PK~~~~~~~~~~~~~~~~ 734 (829) T 6W2Y_A 692 Q---DAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQD 734 (829) T ss_dssp T---TTHHHHHHHHHHHHHHHHHHHHTHHHHHHHC----------- T ss_pred h---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccchhhhh Confidence 2 355678889999999999999999999999998887765543 No 5 >6W2X_B Gamma-aminobutyric acid type B receptor; Inhibitor, Heterodimer, GPCR, SIGNALING PROTEIN; HET: SGG, L9Q, NAG; 3.6A {Homo sapiens} Probab=100.00 E-value=8.6e-65 Score=611.36 Aligned_cols=678 Identities=20% Similarity=0.302 Sum_probs=482.9 Template_Neff=9.500 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQ 115 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~ 115 (908) ........++++||+++|.++.... ...+.....|+++|++++|+++ .++|+++++.+.|+++++..+.+. T Consensus 13 ~~~~~~~~~~i~IG~l~p~s~~~~~--------~~~g~~~~~a~~~Av~~IN~~~-~l~~~~l~l~~~Dt~~~~~~a~~~ 83 (908) T 6W2X_B 13 APRPPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNES-LLRPYFLDLRLYDTECDNAKGLKA 83 (908) T ss_dssp -------CCEEEEEEECCCCSSSTT--------THHHHSSHHHHHHHHHHHHHHT-CSSSCEEEEEEECCTTCHHHHHHH T ss_pred CCCCCCCCCCEEEEEEEeCCccccC--------CcccccHHHHHHHHHHHHHhcC-CCCCeEEEEEEecCCCChHHHHHH Confidence 3445567889999999999874310 0246678899999999999875 466899999999998876544443 Q NP_000836.2 116 SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 116 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) +.+++. . .+++++++|+.++..+.+++.+++.+++|+|+++++++.++++..+++++|+ T Consensus 84 ~~~ll~----~-----------------~~~v~aviG~~~S~~~~~va~~~~~~~ip~Is~~ats~~Ls~~~~yp~ffrt 142 (908) T 6W2X_B 84 FYDAIK----Y-----------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRT 142 (908) T ss_dssp HHHHHH----T-----------------SCCCCCEEECCSHHHHHHHTTSCTTTTCCEEESSCCCSGGGCTTTCSSEEES T ss_pred HHHHHH----h-----------------CCCeEEEEecCCHHHHHHHHHHhcccCCEEEEcccCChhHcCcccCCceeec Confidence 333332 1 1368899999988888888999999999999999988888776678999999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) .|++..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++ T Consensus 143 ~ps~~~~~~al~~ll~~~~W~~Vaii~~d~~~g~~~~~~~~~~~~~~-gi~i~~~~~~~-----~d~~~~l~~lk~-~~a 215 (908) T 6W2X_B 143 VPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDV 215 (908) T ss_dssp SCCTTSSHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHTTTS-SCEEEEEEEES-----SCCHHHHHHHHH-HTC T ss_pred CCCHHhhcHHHHHHHHHcCCcEEEEEEeccHHHHHHHHHHHHHHhcC-CCEEeeEeeec-----CChhHHHHHHhc-CCc Confidence 99999999999999999999999999988888888888888877775 46765443332 234556677763 578 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGF 341 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~ 341 (908) ++|++......+..+++++.+.|+.+ ++.|+..+ |........ ......+|.+.+.........+ T Consensus 216 riIv~~~~~~~~~~~l~~a~~~g~~~~~~vwI~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~i~~~~~~~~~~~~ 294 (908) T 6W2X_B 216 RIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQI 294 (908) T ss_dssp CEEECCCCHHHHHHHHHHHHHHTCCSTTCEEECCC-CCCTTTTC------------CHHHHHHHSSEEEEEECSSCCCCC T ss_pred EEEEEeCCHHHHHHHHHHHHHcCCCCCCeEEEeec-CCCcchHHhccccccCCcchHHHHHHHHCCceEEEecCCCcCcc Confidence 99888877777888999998888764 57788764 322110000 0111223333222111000000 Q NP_000836.2 342 DRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHK 421 (908) Q Consensus 342 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~ 421 (908) ..+ ......++. +.+.+... ...+..++.++|||++++|+|++++.. T Consensus 295 ~~~----------~~~~~~~~~-~~~~~~~~----------------------~~~~~~~~~~aYDAv~~lA~Al~~~~~ 341 (908) T 6W2X_B 295 KTI----------SGKTPQQYE-REYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAME 341 (908) T ss_dssp CCT----------TSCCHHHHH-HHHHHHCS----------------------SSCCCTTHHHHHHHHHHHHHHHHHHHH T ss_pred ccc----------CCCCHHHHH-HHHHhhcC----------------------CCCCccchHHHHHHHHHHHHHHHHHHH Confidence 000 000011111 11211100 012345678899999999999999876 Q NP_000836.2 422 DLCPGY----IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLH- 496 (908) Q Consensus 422 ~~~~~~----~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~- 496 (908) ..+... ...+.......+..+.++|++.+|.|.+| ++.|| +|++...+.+.+++ ++.++.||.|+.... T Consensus 342 ~~~~~~~~~~l~~~~~~~~~~g~~l~~~l~~~~F~G~tG-~v~Fd-~Gdr~~~~~I~~~~----~~~~~~VG~~~~~~~~ 415 (908) T 6W2X_B 342 TLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADT 415 (908) T ss_dssp HHHTC-----CCSCCTTCHHHHHHHHHHHTSCCCEETTE-ECCBS-SSSBCCEEEEEEEC----SSSEEEEEEEETTTTE T ss_pred HHHhcCCCCcHHhcCCCChHHHHHHHHHHHcCceecCce-eEEEe-CCceeceEEEEEEe----CCeEEEEEEEECCCCe Confidence 432110 00010111224556778888889999988 89999 89998889999988 257899999986421 Q NP_000836.2 497 --LKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPI 574 (908) Q Consensus 497 --~~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~ 574 (908) +....+.|.+ |. +|.+ ++.| .. T Consensus 416 l~~~~~~i~w~g----------------~~-------------------------------~P~d------~~~~---~~ 439 (908) T 6W2X_B 416 LEIINDTIRFQG----------------SE-------------------------------PPKD------KTII---LE 439 (908) T ss_dssp EECCTTTCCCSS----------------SS-------------------------------CCCS------SCCE---EC T ss_pred EEEEccccccCC----------------CC-------------------------------CCCC------ccch---hh Confidence 1111223321 10 2333 3333 23 Q NP_000836.2 575 IKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPD-------TII 647 (908) Q Consensus 575 ~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~-------~~~ 647 (908) ....++.++.+++.++++++++++++++++++++|+++.+|++++.+++++|+|++++|++++++++.++ ... T Consensus 440 ~~~~~~~~~~~~~~~~~~~gi~~~~~~l~~~~~~r~~~~ik~s~~~l~~~il~G~~l~~~~~~~~~~~~~~~~~~~~~~~ 519 (908) T 6W2X_B 440 QLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETL 519 (908) T ss_dssp CCCCCCSSSHHHHHHHHHHHHHHHHHHHHHHHHTTTSHHHHHSCSSHHHHHHHHHHHHHHHHHHHHCCSSSSCHHHHHHH T ss_pred HHhcCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcchhHHhCCHHHHHHHHHHHHHHHHHHHHHhcCCCCCChhHHHHH Confidence 3336677788888899999999999888899999999999999999999999999999999999888776 789 Q NP_000836.2 648 CSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGE 727 (908) Q Consensus 648 C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~ 727 (908) |.+|.|++++||+++||+|++|+||++++|++++.+ ++.++++.++.+++++++++++++++|++++|+........ T Consensus 520 C~~~~w~~~lgf~l~~g~l~~K~~Ri~~if~~~~~~---~~~~~~~~l~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~ 596 (908) T 6W2X_B 520 CTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYS 596 (908) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC----------CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC T ss_pred HHHHHHHHHHHHHHHHHHHHHhHHHHHHHHcCcccc---ccccCHHHHHHHHHHHHHHHHHHHHHHHHhCccchhhhccc Confidence 999999999999999999999999999999876543 34678889999999999999999999999999876532110 Q NP_000836.2 728 QRT----LDPEKARGVLKCDIS--DLSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPI 800 (908) Q Consensus 728 ~~~----~~~~~~~~~~~C~~~--~~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~ 800 (908) ... .+.........|.+. ..|++++++|+++|+++|++|||++|++| ++|||+|+|++++|+++++|++++++ T Consensus 597 ~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~y~~llll~~~~la~~tR~v~~~~~nEsk~i~~a~~~~~~~~~~~~~~ 676 (908) T 6W2X_B 597 MEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAV 676 (908) T ss_dssp CBCC-----CEECCEEEEEECSSCHHHHHHHHHHHHHHHHHHHHHHHHTSSCCCSSCCCHHHHHHHHHHHHHHHHHHHHH T ss_pred CCCCCCCCCceeeceEEeecCCccHHHHHHHHHHHHHHHHHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHHHHHHHH Confidence 000 000012445789885 37888999999999999999999999999 99999999999999999999999999 Q NP_000836.2 801 FFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 801 ~~~~~~~~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) +++....+ .+.+++.+++++++++++|+++|+||+|.++++|+++.... T Consensus 677 ~~~~~~~~---~~~~~~~~~~i~~~~~~~l~~if~PK~~~i~~~~~~~~~~~ 725 (908) T 6W2X_B 677 SFLTRDQP---NVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNR 725 (908) T ss_dssp HHHCSSSH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred HHHhcCCh---hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCcchhcccc Confidence 88765432 35667888999999999999999999999999988765543 No 6 >6UO8_A Gamma-aminobutyric acid type B receptor; G protein-coupled receptor, GABA, GABAB; HET: BMA, QDA, NAG;{Homo sapiens} Probab=100.00 E-value=9.3e-65 Score=605.48 Aligned_cols=682 Identities=21% Similarity=0.300 Sum_probs=482.9 Template_Neff=10.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++++||+++|.+++. ..+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.+++. T Consensus 3 ~~~~i~Ig~l~p~s~~~-----------~~~~~~~~a~~~Av~~iN~~~~il~g~~l~~~~~D~~~~~~~a~~~~~~l~~ 71 (762) T 6UO8_A 3 ERRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLY 71 (762) T ss_dssp CCEEEEEEEEECCSSSC-----------CCHHHHHHHHHHHHHHHTTCTTTCSSEEEEEEEEECTTCHHHHHHHHHHHHT T ss_pred CceeEEEEEEEecCCCC-----------CCcccHHHHHHHHHHHHHcCCCCCCCcEEEEEEccCCCCHHHHHHHHHHHHh Confidence 45789999999998753 1356678999999999999888888999999999998875544333333322 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++++++++|+.++..+..++.+++.+++|++++.++++.++++..+|+++|+.|++.. T Consensus 72 ----------------------~~~v~~viG~~~s~~~~~va~~~~~~~ip~is~~a~s~~ls~~~~~p~~fr~~ps~~~ 129 (762) T 6UO8_A 72 ----------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATL 129 (762) T ss_dssp ----------------------SSSCEEEEECCSHHHHHHHHHHGGGTTCEEEESSCCCGGGGCTTTCTTEEECSCCGGG T ss_pred ----------------------cCCcEEEEECCCHHHHHHHHHHHHHcCCEEEecccCChhhhccccCCceeecCCChhh Confidence 1478899999888888888889999999999999888877766678999999999999 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) +++++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++|+|++. T Consensus 130 ~~~a~~~~l~~~~w~~vaii~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~-----~~~~~~l~~l~~-~~~~vIv~~ 202 (762) T 6UO8_A 130 HNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIVGL 202 (762) T ss_dssp SHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHTGGG-SCEEEECCEES-----SCCHHHHHHHHH-HTCSEEEEE T ss_pred ccHHHHHHHHHhCCcEEEEEEeCCccchhHHHHHHHHHHHc-CcEEEEEeccc-----CCchHHHHHHHh-CCCEEEEEe Confidence 99999999999999999999988888888888888887775 46665443332 134445666763 578988888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSD----SWGSKIAP-----VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~----~~~~~~~~-----~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .....+..+++++++.|+.+ ++.|+..+ .|...... ........+|.+...... .... .. T Consensus 203 ~~~~~~~~~l~~a~~~g~~~~~~v~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~---------~~~~-~~ 272 (762) T 6UO8_A 203 FYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVM---------LNPA-NT 272 (762) T ss_dssp CCSHHHHHHHHHHGGGTCCSSSCEEEEESCSCTTTTSSCCTTCCCCTHHHHTTSCSEEEEEECC---------SCCS-CC T ss_pred CCHHHHHHHHHHHHHcCcCCCCeEEEEEcccccchhhhcCCCCCCCHHHHHHHHCCcEEEEeec---------cCCC-CC Confidence 77777888999998888754 56777653 22211000 000111222322211100 0000 00 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLC 431 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~ 431 (908) ....+.++.++++++... .... + . ......++..+|||++++++|+++.....+.. +.+ T Consensus 273 ~~~~~~~~~~f~~~~~~~-~~~~---~----~-----------~~~~~~~~~~~yDav~~~a~al~~~~~~~~~~--~~~ 331 (762) T 6UO8_A 273 RSISNMTSQEFVEKLTKR-LKRH---P----E-----------ETGGFQEAPLAYDAIWALALALNKTSGGGGRS--GVR 331 (762) T ss_dssp CCTTSCCTTHHHHHHHHH-CSSC---T----T-----------TSTTCTTHHHHHHHHHHHHHHHHHHC----------C T ss_pred cCcCCCCHHHHHHHHHHH-HhcC---C----c-----------cCCCCccccHHHHHHHHHHHHHHHHhhcCccC--CCC Confidence 001122333433322111 1000 0 0 01123457789999999999999986543211 000 Q NP_000836.2 432 PR----MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 432 ~~----~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) .. .....++.+.+.|++.+|.|.+| ++.||++|++...+.+.+++ ++.++.||.|+.... .+.|... T Consensus 332 ~~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~v~fd~~G~r~~~~~i~~~~----~~~~~~vg~~~~~~~----~~~~~~~ 402 (762) T 6UO8_A 332 LEDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDSTKD----DLSWSKT 402 (762) T ss_dssp TTCCCSSCCTTHHHHHHHHHTCCCBCSSS-BCCCSSSSCCCCCEEEEEEE----TTEEEEEEEECSSSC----CCCCCCC T ss_pred HHHcCCCCHHHHHHHHHHHHcCcccccce-eeEeCCCCCccceEEEEEEe----CCeEEEEEEEECCCC----ceeecCC Confidence 00 01123446777888889999988 89999999998888888887 357899999986521 2344211 Q NP_000836.2 508 EHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVP 587 (908) Q Consensus 508 ~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~~~~ 587 (908) ..|+.|. +|.| ++.| +..+..++.++.+++ T Consensus 403 ----------~~~~~g~-------------------------------~p~d------~~~~---~~~~~~~~~~~~~~~ 432 (762) T 6UO8_A 403 ----------DKWIGGS-------------------------------PPAD------QTLV---IKTFRFLSQKLFISV 432 (762) T ss_dssp ----------CCCGGGS-------------------------------CCCC------CCCE---EEECCCCTTHHHHHH T ss_pred ----------CccCCCC-------------------------------CCCC------ccee---hhccchhCHHHHHHH Confidence 1222221 2333 4444 333445567778888 Q NP_000836.2 588 VFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFL------MIAAP-DTIICSFRRVFLGLGMC 660 (908) Q Consensus 588 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~------~~~~~-~~~~C~~~~~~~~~gf~ 660 (908) .++++++++++++++++++++|+++.+|+++|.+++++|+|++++|+++++ ++..+ +...|.+|.|++++||+ T Consensus 433 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~l~~~~l~g~~l~~~~~~~~~~~~~~i~~~~~~~~C~~~~~~~~~gf~ 512 (762) T 6UO8_A 433 SVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFS 512 (762) T ss_dssp HHHHHHHHHHHHHHHHHHHHSCCSHHHHSSCTHHHHHHHHHHHHHHTTSHHHHCCTTTTTTTCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHccCChhHhccCHHHHHHHHHHHHHHHHhHHhhCCCCCCCCccchHHHHHHHHHHHHHhHH Confidence 899999999999999999999999999999999999999999999999986 34445 68999999999999999 Q NP_000836.2 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT----LDPEKA 736 (908) Q Consensus 661 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~----~~~~~~ 736 (908) ++||++++|+||++++|++++.++..++.++++.++.+++++++++++++++|+.++|+..........+ .+.... T Consensus 513 l~~~~l~~k~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~ 592 (762) T 6UO8_A 513 LGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSIL 592 (762) T ss_dssp HHHHHHHHHHHHHHHTTSCCSSCTTCSSCSSTHHHHHHHHHHHHHHHHHHHHHHHSSCCCCEEEECCCCCCCSSSSCCEE T ss_pred HHHhhhhhcceEEEEEeecccccchhhcccCHHHHHHHHHHHHHHHHHHHHHHHHhCcccceeeecccCCCCccCCceEe Confidence 9999999999999999997654322244678899999999999999999999999999976543211000 000012 Q NP_000836.2 737 RGVLKCDISD--LSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813 (908) Q Consensus 737 ~~~~~C~~~~--~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 813 (908) .....|.+.+ .|++++++|+++|++++++|||++|++| ++|||+|+|++++|+++++|++++++++.....+ .. T Consensus 593 ~~~~~C~~~~~~~~~~~~~~~~~~ll~~~~~la~~tr~~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~---~~ 669 (762) T 6UO8_A 593 PQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQ---DA 669 (762) T ss_dssp EEEEECCCSCCTTHHHHHHHHHHHHHHHHHHHHHSCCSCCSSCSSHHHHHHHHHHHHHHHHHHHHHHHTTCCCTT---TS T ss_pred ceeeeeecCCchHHHHHHHHHHHHHHHHHHHHHHHhcCCCChhhccHHHHHHHHHHHHHHHHHHHHHHHHhcCCh---hH Confidence 2356999864 7888999999999999999999999999 9999999999999999999999999987665432 35 Q NP_000836.2 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF 856 (908) Q Consensus 814 ~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~~ 856 (908) .+.+.+++++++++++|+++|+||+|.++++++.+......++ T Consensus 670 ~~~~~~~~i~~~~~~~l~~~f~Pk~~~~~~~~~~~~~~~~~~~ 712 (762) T 6UO8_A 670 AFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMK 712 (762) T ss_dssp HHHHHHHHHHHHHHHHHHHHHSHHHHHHHC------------- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccchhhhhcc Confidence 6678889999999999999999999999999988776554443 No 7 >6UO8_B Gamma-aminobutyric acid type B receptor; G protein-coupled receptor, GABA, GABAB; HET: BMA, QDA, NAG;{Homo sapiens} Probab=100.00 E-value=2.2e-64 Score=602.93 Aligned_cols=675 Identities=21% Similarity=0.307 Sum_probs=484.0 Template_Neff=10.500 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....+++++||+++|.++.... ...+.....|+++|++++|+++ .++|+++++.+.|+++++..+.+.+.+ T Consensus 9 ~~~~~~~i~Ig~l~p~~~~~~~--------~~~g~~~~~a~~~Av~~iN~~~-~l~~~~l~~~~~D~~~~~~~a~~~~~~ 79 (779) T 6UO8_B 9 PPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNES-LLRPYFLDLRLYDTECDNAKGLKAFYD 79 (779) T ss_dssp ----CCEEEEEEECCCCSSSSS--------SHHHHHHHHHHHHHHHHHHTTC-SSTTSEEEEEEECCTTCHHHHHHHHHH T ss_pred CCCCCCCeEEEEEEEcCccccC--------CcccccHHHHHHHHHHHHHhcc-CCCCcEEEEEEecCCCChHHHHHHHHH Confidence 4566789999999999875310 0245678899999999999875 456899999999998876544433333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++.. .+++++++|+.++..+.+++.+++.+++|+|+++++++.++++..+++++|+.|+ T Consensus 80 l~~~---------------------~~~v~~viG~~~s~~~~~va~~~~~~~ip~is~~ats~~ls~~~~~p~~~rt~ps 138 (779) T 6UO8_B 80 AIKY---------------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 138 (779) T ss_dssp HHHT---------------------SCCEEEEEECCSTTHHHHHHTTCTTTTCCEEESSCCCGGGGCTTSCTTEEESSCC T ss_pred HHHh---------------------CCCEEEEEecCChHHHHHHHHHcCccCCEEEecccCChhHcCcccCCCceecCCC Confidence 3221 1368899999988888888999999999999999988888876678999999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) +..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....++ .+..+.++++++ .++++| T Consensus 139 ~~~~~~a~~~~l~~~~W~~v~ii~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~-----~d~~~~l~~l~~-~~~~iI 211 (779) T 6UO8_B 139 DNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDVRII 211 (779) T ss_dssp TTSSHHHHHHHHTTTTCCCEEEEECSSSHHHHHHHHHHHHTSSS-SCCEEEEEECS-----SCGGGTHHHHHH-TTCCEE T ss_pred HhhhcHHHHHHHHHcCCCEEEEEEecchhHHHHHHHHHHHHHhC-CcEEEeeeeec-----CChhHHHHHHhh-CCcEEE Confidence 99999999999999999999999988888888888888877765 46665443332 234556777763 588998 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++......+..+++++++.|+.+ +++|+..+ |........ ......+|.+.+.........+..+ T Consensus 212 v~~~~~~~~~~~l~~a~~~g~~~~~~~wi~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 290 (779) T 6UO8_B 212 LGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTI 290 (779) T ss_dssp EEECCHHHHHHHHHHHHHTTCCSTTCEEEEEC-CCCTTTTTTSCSSSCCTTSCSHHHHTTSCSCEEEEECSSCSSCCCCS T ss_pred EEeCCHHHHHHHHHHHHHcCCCCCcEEEEeec-CCCcchhHhhcccccCCCccHHHHHHHHCCceeeEecCCCCCCcccc Confidence 88877777888999998888754 57788764 322110000 0111223333222111000000000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ......+ |.+.+.+... ...+..++.++|||++++++|++++....+ T Consensus 291 ----------~~~~~~~-~~~~~~~~~~----------------------~~~~~~~~~~~yDAv~~~a~al~~~~~~~~ 337 (779) T 6UO8_B 291 ----------SGKTPQQ-YEREYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAMETLH 337 (779) T ss_dssp ----------SSSCHHH-HHHHHHHHSS----------------------SCCCCSCSSTTHHHHHHHHHHHHHHHSSSC T ss_pred ----------CCCCHHH-HHHHHHhhcC----------------------CCCccccchHHHHHHHHHHHHHHHHHHHHH Confidence 0000111 1111211000 012345678899999999999999875432 Q NP_000836.2 425 PGY----IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLH---L 497 (908) Q Consensus 425 ~~~----~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~---~ 497 (908) ... ...+.......+..+.+++++.+|.|.+| ++.|| +|++...+.+.+++ ++.++.||.|+.... + T Consensus 338 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~sG-~v~f~-~g~r~~~~~i~~~~----~~~~~~vg~~~~~~~~l~~ 411 (779) T 6UO8_B 338 ASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADTLEI 411 (779) T ss_dssp SHHHHHTTSCCCSCCHHHHHHHHHHHHCCCCBCSSS-BCEEE-TTEEECEEEEEEEC----SSSEEEEEEEESSSCCEEE T ss_pred hcCCCCCHHHcCCCCHHHHHHHHHHHHcCCccccce-eEEEe-CCceecEEEEEEEe----CCeEEEEEEEECCCCeEEE Confidence 110 00010111224556778888889999988 89999 89998889999988 257899999986521 1 Q NP_000836.2 498 KVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKL 577 (908) Q Consensus 498 ~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~ 577 (908) +...+.|.+ |. +|.+ ++.| ..... T Consensus 412 ~~~~~~~~~----------------~~-------------------------------~P~d------~~~~---~~~~~ 435 (779) T 6UO8_B 412 INDTIRFQG----------------SE-------------------------------PPKD------KTII---LEQLR 435 (779) T ss_dssp CTTTCCCSS----------------SS-------------------------------CCCS------SCCE---EEEEC T ss_pred ecccceeCC----------------CC-------------------------------CCCC------Ccee---eeecc Confidence 111223321 10 2333 3333 23333 Q NP_000836.2 578 EWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPD-------TIICSF 650 (908) Q Consensus 578 ~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~-------~~~C~~ 650 (908) .++.++.+++.+++++|++++++++++++++|+++.+|++++.+++++|+|++++|++++++++.++ ...|.+ T Consensus 436 ~~~~~~~~~~~~~~~~gi~~~~~~~~~~~~~r~~~~ik~s~~~~~~~il~g~~l~~~~~~~~~~~~~~~~~~~~~~~C~~ 515 (779) T 6UO8_B 436 KISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTV 515 (779) T ss_dssp CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTSTTCTTCCHHHHHHHHHHHHHHHHHHHHHCCCTTTTTTTSHHHHHHH T ss_pred cCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCChhHhcCCHHHHHHHHHHHHHHHHHHHHhcCCCCCCChhHHHHHHHh Confidence 5677788888899999999999888999999999999999999999999999999999999887775 689999 Q NP_000836.2 651 RRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT 730 (908) Q Consensus 651 ~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~ 730 (908) |.|++++||+++||+|++|+||++++|++.+.+ ++.++++.++.+++++++++++++++|++++|+........... T Consensus 516 ~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~---~~~~~~~~l~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~~~~ 592 (779) T 6UO8_B 516 RTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEP 592 (779) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTSCCC-----CCCSCSSHHHHHHHHHHHHHHHHHHTTTTTCCCCCCCEECCCCC T ss_pred HHHHHHHHHHHHHHHhHHHHHhHHhHhcccccc---CcccCHHHHHHHHHHHHHHHHHHHHHHHHhCcccceeeeeecCC Confidence 999999999999999999999999999876543 34678888999999999999999999999999876532110000 Q NP_000836.2 731 ----LDPEKARGVLKCDIS--DLSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFG 803 (908) Q Consensus 731 ----~~~~~~~~~~~C~~~--~~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~ 803 (908) .+.........|.+. ..|++++++|+++|+++|++|||++|++| ++|||+|+|++++|+++++|+++++++++ T Consensus 593 ~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~y~~~ll~~~~~la~~~r~~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~ 672 (779) T 6UO8_B 593 DPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFL 672 (779) T ss_dssp CCSSCCCEEEEEECCCCCTTTTSSSHHHHHHHHHHHHHHHHHHHHHHTSCCCTTSCSSHHHHHHHHHHHHHHHHHHHHTT T ss_pred CCCCCCceEeeeEeeecCCChHHHHHHHHHHHHHHHHHHHHHHHHhcCCCChhhcchhHHHHHHHHHHHHHHHHHHHHHH Confidence 000012345799885 37888999999999999999999999999 99999999999999999999999999876 Q NP_000836.2 804 TAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 804 ~~~~~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) ....+ ...+.+.+++++++++++|+++|+||+|.++++|+.+...+ T Consensus 673 ~~~~~---~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 718 (779) T 6UO8_B 673 TRDQP---NVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNR 718 (779) T ss_dssp CCSCT---TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred hcCCc---hHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccCcchhhhcc Confidence 65432 35567888999999999999999999999999998876644 No 8 >7C7Q_A Gamma-aminobutyric acid type B receptor; GABAB, Cryo-EM, GPCR, active, PAM; HET: FN0, 2C0, NAG;{Homo sapiens} Probab=100.00 E-value=3.4e-62 Score=592.43 Aligned_cols=685 Identities=20% Similarity=0.285 Sum_probs=475.7 Template_Neff=10.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+++. ..+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.+ T Consensus 166 ~~~~~~i~Ig~l~p~~~~~-----------~~~~~~~~a~~~Av~~iN~~~~il~~~~l~l~~~D~~~~~~~a~~~~~~- 233 (879) T 7C7Q_A 166 HSERRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYE- 233 (879) T ss_dssp --CCEEEEEEEECCCSSSC-----------CTHHHHHHHHHHHHHHHHHCTTTCSSEEEEEEEECCTTCHHHHHHHHHH- T ss_pred CccCCceEEEeEecCCCCC-----------CCccchHHHHHHHHHHHHhCCCCCCCCEEEEEEcCCCCChHHHHHHHHH- Confidence 3456889999999998743 1356678999999999999888888999999999998876544333333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++. ++++++++|+.++..+..++.+++..++|+|++.++++.++++..+++++|+.|++ T Consensus 234 ---l~~------------------~~~v~~viG~~~s~~~~~~a~~~~~~~ip~is~~a~s~~ls~~~~~~~~~r~~ps~ 292 (879) T 7C7Q_A 234 ---LLY------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSA 292 (879) T ss_dssp ---HHT------------------SSSCEEEEEECSHHHHHHHHHHGGGTTCEEEESSCCCGGGGCTTTSTTEEESSCCG T ss_pred ---HHh------------------CCCeEEEEEcCChHHHHHHHHHHHhcCCEEEecccCChhhhccccCCceEEcCCCh Confidence 322 15788999998888777888899999999999998877777666789999999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ..+++++++++++++|++|++++++++++....+.+++.+++. ++++.....+. .+....++++++ .++|+|+ T Consensus 293 ~~~~~a~~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-gi~v~~~~~~~-----~~~~~~l~~l~~-~~~~vIv 365 (879) T 7C7Q_A 293 TLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIV 365 (879) T ss_dssp GGHHHHHHHHHHHTTCCEEEEEEESCHHHHHHHHHHHHHHHHH-TCEEEEEEEES-----SCCHHHHHHHHH-TTCCEEE T ss_pred hhccHHHHHHHHHhCCCEEEEEEECCCcchHHHHHHHHHHHHc-CcEEEEEeccc-----CCchHHHHHHHh-CCCEEEE Confidence 9999999999989999999999988888888888888888775 46765443332 133455666763 5889998 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSG-HFLWIGSD----SWGSKIAP-----VYQQEEIAEGAVTILPKRASIDGFDRYFRSRT 349 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~----~~~~~~~~-----~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~ 349 (908) +......+..+++++++.|+.+ ++.|+..+ .|...... ........+|.+....... ... T Consensus 366 ~~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~---------~~~- 435 (879) T 7C7Q_A 366 GLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVML---------NPA- 435 (879) T ss_dssp EECCHHHHHHHHHHHHHHTCCSSSCEEEEETTSCTTTTTSCCTTCCSCHHHHHHHSSSCEEEEECCS---------CCS- T ss_pred EecCHHHHHHHHHHHHHcccCCCCEEEEEecccccccccccCCCCCCCHHHHHHHHcCcEEEEeecc---------CCC- Confidence 8877777888999998888754 46777653 22211000 0000112223222111000 000 Q NP_000836.2 350 LANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYI- 428 (908) Q Consensus 350 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~- 428 (908) ......+.++.++++++... .... + . ......++..+|||++++++|++++....+.... T Consensus 436 ~~~~~~~~~~~~f~~~~~~~-~~~~---~----~-----------~~~~~~~~~~~yDAv~~~a~Al~~~~~~~~~~~~~ 496 (879) T 7C7Q_A 436 NTRSISNMTSQEFVEKLTKR-LKRH---P----E-----------ETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVR 496 (879) T ss_dssp CCCCTTSCCHHHHHHHHHHH-SSSC---G----G-----------GSTTTTSHHHHHHHHHHHHHHHHHTC--------C T ss_pred CCcccCCCCHHHHHHHHHHH-HhcC---C----c-----------cCCCCcccchHHHHHHHHHHHHHHHhcccccCCCC Confidence 00000122333333322111 1000 0 0 0112345778999999999999998754321100 Q NP_000836.2 429 GLCPR-MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 429 ~~~~~-~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) ..+.. .....++.+.++|++.+|.|.+| ++.||++|++...+.+.+++ ++.++.+|.|+.... .+.|... T Consensus 497 ~~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~v~fd~~G~r~~~~~i~~~~----~~~~~~vg~~~~~~~----~~~~~~~ 567 (879) T 7C7Q_A 497 LEDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDSTKD----DLSWSKT 567 (879) T ss_dssp CTTCCTTCCHHHHHHHHHHHTCEEEETTE-EEECCSSCCCCCEEEEEEEC----SSSEEEEEEEETTTT----EEEECSC T ss_pred HHHCCCCCHHHHHHHHHHHHcCcccccee-eEEeCCCCCccceEEEEEEe----CCEEEEEEEEECCCC----ceeeccC Confidence 00000 01123456778888889999988 89999999998888888887 357899999986521 2344211 Q NP_000836.2 508 EHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVP 587 (908) Q Consensus 508 ~~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~~~~ 587 (908) ..|+.|. +|.+ .+.| ...+..++..+.+++ T Consensus 568 ----------~~w~~g~-------------------------------~p~~------~~~~---~~~~~~~~~~~~i~~ 597 (879) T 7C7Q_A 568 ----------DKWIGGS-------------------------------PPAD------QTLV---IKTFRFLSQKLFISV 597 (879) T ss_dssp ----------CCCTTSS-------------------------------CCCS------SCCE---EEEECCCCHHHHHHH T ss_pred ----------CccCCCC-------------------------------CCcc------ccee---eeecchhCHHHHHHH Confidence 1222221 2333 3333 233445556777888 Q NP_000836.2 588 VFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFL------MIAAP-DTIICSFRRVFLGLGMC 660 (908) Q Consensus 588 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~------~~~~~-~~~~C~~~~~~~~~gf~ 660 (908) .++++++++++++++++++++|+++.+|++++.+++++|+|++++|+++++ ++..| +...|.+|.|++++||+ T Consensus 598 ~~~~~~~i~~~~~~~~~~~~~r~~~~i~~~~~~l~~~il~g~~l~~~~~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~f~ 677 (879) T 7C7Q_A 598 SVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFS 677 (879) T ss_dssp HHHHHHHHHHHHHHHHHHHHTSSSSGGGGSCHHHHHHHHHHHHHHHHTHHHHHCCTTTSCSTTTHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHcccChhHhccCHHHHHHHHHHHHHHHHHHHHhcCCccCCCccchhHHHHHHHHHHHHhHH Confidence 888999998888888889999999999999999999999999999999986 34445 68899999999999999 Q NP_000836.2 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT----LDPEKA 736 (908) Q Consensus 661 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~----~~~~~~ 736 (908) ++||+|++|+||++++|++++.++.+++.++++.++.++++++++|++++++|++++|+..........+ .+.... T Consensus 678 l~~~~l~~K~~ri~~if~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~il~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~ 757 (879) T 7C7Q_A 678 LGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSIL 757 (879) T ss_dssp HHHSTTTHHHHHHHHHCC-----------CCTTHHHHHHHHHHHHHHHHHHHHHHHSCCEEEEEECCCCCCTTSSSCEEE T ss_pred HHHHHHhccceEEEEEeecccccchhhccCCHHHHHHHHHHHHHHHHHHHHHHHHhCcccceeeecccCCCCcCCCeeEe Confidence 9999999999999999997654322234678888999999999999999999999999976543211000 000012 Q NP_000836.2 737 RGVLKCDISD--LSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813 (908) Q Consensus 737 ~~~~~C~~~~--~~~~~~~~~~~~ll~~~~~la~~~R~~~-~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 813 (908) .....|.+.+ .+++++++|+++|++++++|||++|++| ++|||+|+|++++|+++++|+++++++++..... .. T Consensus 758 ~~~~~C~~~~~~~~~~~~~~~~~~ll~~~~~la~~tR~~~~~~~nesk~i~~~~~~~~~~~~~~~~~~~~~~~~~---~~ 834 (879) T 7C7Q_A 758 PQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQ---DA 834 (879) T ss_dssp EEEEEEECSSCSSHHHHHHHHHHHHHHHHHHHHHHTSSCCCSSSSCHHHHHHHHHHHHHHHHHHHHHHHHSTTCH---HH T ss_pred ceEeEeecCCchHHHHHHHHHHHHHHHHHHHHHHHhcCCCchhhccHHHHHHHHHHHHHHHHHHHHHHHHhcCCh---HH Confidence 2367999864 6778899999999999999999999999 9999999999999999999999999987665432 24 Q NP_000836.2 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRS 855 (908) Q Consensus 814 ~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 855 (908) .+.+.+++++++++++|+++|+||+|.++++++++..++... T Consensus 835 ~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~~ 876 (879) T 7C7Q_A 835 AFAFASLAIVFSSYITLVVLFVPKMRRLITEVLFQGPHHHHH 876 (879) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC------------ T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccCCCCCCCC Confidence 566888999999999999999999999999998887665443 No 9 >2E4U_A Metabotropic glutamate receptor 3; G-protein-coupled receptor, neuron, central nerve; HET: GLU, NAG; 2.35A {Rattus norvegicus} Probab=100.00 E-value=1.2e-43 Score=406.76 Aligned_cols=535 Identities=46% Similarity=0.875 Sum_probs=346.7 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|++++...+.+.+.++ T Consensus 9 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~D~~~~~~~a~~~~~~~ 88 (555) T 2E4U_A 9 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEF 88 (555) T ss_dssp EEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHHHCTTSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred eEecCCEEEEeeecceecCCCCCCccccccccCHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEeeCCCCHHHHHHHHHHH Confidence 45578999999999987543233455333345677889999999999999888889999999999988765544444443 Q NP_000836.2 120 VQALIEK-DASDVKCANGDPPIFTK-PDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 120 ~~~l~~~-~~~~~~~~~~~~~~~~~-~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +...... ......|....+.+... ..+++++||+.++..+..++.++..+++|+|++++.++.++++..+++++++.| T Consensus 89 ~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~l~~~~~~~~~~r~~p 168 (555) T 2E4U_A 89 VRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVP 168 (555) T ss_dssp HHTTC--------------------CCCCEEEEEECSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESSC T ss_pred HHHhccCcccccccCCCCCcccccCCCCcEEEEEcCCChHHHHHHHHHhHhhCCCEEecCcCCcccCCCCcCCCccccCC Confidence 3210000 00000000000000000 035789999988888888889999999999999887777766556899999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|++|++|+.+++++....+.+.+.+++. ++++.....++......++...++++++..++++ T Consensus 169 ~~~~~~~~l~~~l~~~~w~~v~~i~~~~~~g~~~~~~~~~~~~~~-~i~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v 247 (555) T 2E4U_A 169 PDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NICIATAEKVGRSNIRKSYDSVIRELLQKPNARV 247 (555) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHTT-TCEEEEEEEECTTCCHHHHHHHHHHHHTCTTCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEEcCcchHHHHHHHHHHHHHC-CCEEEEEEEeccccccccHHHHHHHHHhCCCccE Confidence 999999999999999999999999988888888888888887765 4666543333211112345555666632247888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) |++.+....+..+++++.+.|+ ++.|++.+.|...............+.+.+.......++|..|+....+...+.+. T Consensus 248 vv~~~~~~~~~~~~~~~~~~~~--~~~~i~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~fl~~~~~~~~~~~~ 325 (555) T 2E4U_A 248 VVLFMRSDDSRELIAAANRVNA--SFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP 325 (555) T ss_dssp EEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCGGGTTTCHHHHTTCEEEEECCCCCHHHHHHHHTCCTTTCTTCT T ss_pred EEEECCHHHHHHHHHHHHHcCC--CeEEEEeCcccccchhhcCCcceeceEEEEEEcCCCCccHHHHHHhCCCCcCCCCH Confidence 8888777778888888887776 36788876665432110001123344444443333334455444332222223455 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) ++.++|++.++|..... ......|+..+..... ......++.++||||+++|+||+++....+......|...... T Consensus 326 ~~~~~~~~~~~c~~~~~---~~~~~~c~~~~~~~~~-~~~~~~~~~~~ydAv~~~a~aL~~~~~~~~~~~~~~c~~~~~~ 401 (555) T 2E4U_A 326 WFRDFWEQKFQCSLQNK---RNHRQVCDKHLAIDSS-NYEQESKIMFVVNAVYAMAHALHKMQRTLCPQTTKLCDAMKIL 401 (555) T ss_dssp THHHHHHHHTTCCCC---------CCCCTTCCCCTT-TCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGGTSC T ss_pred HHHHHHHHHcCCccCCc---cCCCcccCCCcccCCC-CccchhhHHHHHHHHHHHHHHHHHHHhccCCCCCCCchhhccc Confidence 67777777666532110 0011123322111100 0122345678999999999999998764332111122211111 Q NP_000836.2 438 DGKE-LLGYIRAVNFN-------GSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREH 509 (908) Q Consensus 438 ~~~~-l~~~l~~~~f~-------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~~~ 509 (908) ++.. +.+.|++..|. |.+| .+.||++|++...|.|++++..++...++.||.|+....++...+.|.++ T Consensus 402 ~~~~~~~~~l~~~~f~~~~~~~~g~~g-~v~fd~~G~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~i~W~~~-- 478 (555) T 2E4U_A 402 DGKKLYKEYLLKIQFTAPFNPNKGADS-IVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRN-- 478 (555) T ss_dssp CHHHHHHHHTTCEEECCSSSCCSSSCC-EEECCTTSCCCCCEEEEEEECTTSSCEEEEEEEESSSEECCGGGCCCTTS-- T ss_pred ChhHHHHHHHHhCcccCCCCCCCCCCC-eeEeCCCCCCCceEEEEEEEeeCCeEEEEEEEEeCCcEEEecccccccCC-- Confidence 2232 44677777773 6677 89999999998889999887432223688999998654344346889753 Q NP_000836.2 510 THPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWA 584 (908) Q Consensus 510 ~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~ 584 (908) ..|.++|+.+|++|++|...+++.|||+|..|++++++++.++|.+||.++|||.+++.|.+++..|+.|.+++. T Consensus 479 ~~P~s~Cs~~C~~G~~k~~~~~~~Cc~~C~~C~~~~~~~~~~~C~~Cp~~~~~n~~~~~C~~~~~~~L~~~~~~~ 553 (555) T 2E4U_A 479 SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDALV 553 (555) T ss_dssp SCCCCCSSCCCCTTTEEEECCSSSSCCEEEECCTTEEEEETTEEEECCTTEEECTTSSSEEECCC---------- T ss_pred CCCcceeeCCCCCCceeecCCCCcccceeeecccceeecCceeecCCCCCcccCCCCCCeEeccccccCcccCCC Confidence 568999999999999988766678999999999999998789999999999999999999999999999887653 No 10 >2E4X_B Metabotropic glutamate receptor 3; G-protein-coupled receptor, neuron, central nerve; HET: C5B, NAG; 2.75A {Rattus norvegicus} Probab=100.00 E-value=1.2e-43 Score=406.76 Aligned_cols=535 Identities=46% Similarity=0.875 Sum_probs=347.2 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|++++...+.+.+.++ T Consensus 9 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~D~~~~~~~a~~~~~~~ 88 (555) T 2E4X_B 9 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEF 88 (555) T ss_dssp EEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHTTCSSSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred eEecCCEEEEeeecceecCCCCCCccccccccCHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEeeCCCCHHHHHHHHHHH Confidence 45578999999999987543233455333345677889999999999999888889999999999988765544444443 Q NP_000836.2 120 VQALIEK-DASDVKCANGDPPIFTK-PDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 120 ~~~l~~~-~~~~~~~~~~~~~~~~~-~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +...... ......|....+.+... ..+++++||+.++..+..++.++..+++|+|++++.++.++++..+++++++.| T Consensus 89 ~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~l~~~~~~~~~~r~~p 168 (555) T 2E4X_B 89 VRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVP 168 (555) T ss_dssp HHHTC--------------------CCCCEEEEEECSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESSC T ss_pred HHHhccCcccccccCCCCCcccccCCCCcEEEEEcCCChHHHHHHHHHhHhhCCCEEecCcCCcccCCCCcCCCccccCC Confidence 3210000 00000000000000000 035789999988888888889999999999999887777766556899999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|++|++|+.+++++....+.+.+.+++. ++++.....++......++...++++++..++++ T Consensus 169 ~~~~~~~~l~~~l~~~~w~~v~~i~~~~~~g~~~~~~~~~~~~~~-~i~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v 247 (555) T 2E4X_B 169 PDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NICIATAEKVGRSNIRKSYDSVIRELLQKPNARV 247 (555) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHHHHTCTTCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEEcCcchHHHHHHHHHHHHHC-CCEEEEEEEeccccccccHHHHHHHHHhCCCccE Confidence 999999999999999999999999988888888888888887765 4666543333211112345555666632247888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) |++.+....+..+++++.+.|+ ++.|++.+.|...............+.+.+.......++|..|+....+...+.+. T Consensus 248 vv~~~~~~~~~~~~~~~~~~~~--~~~~i~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~fl~~~~~~~~~~~~ 325 (555) T 2E4X_B 248 VVLFMRSDDSRELIAAANRVNA--SFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP 325 (555) T ss_dssp EEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCSTTTTTCTTTSTTCEEEEECCCCCHHHHHHHHTCCTTTCTTCT T ss_pred EEEECCHHHHHHHHHHHHHcCC--CeEEEEeCcccccchhhcCCcceeceEEEEEEcCCCCccHHHHHHhCCCCcCCCCH Confidence 8888777778888888887776 36788876665432110001123344444443333334455444332222223455 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) ++.++|++.++|..... ......|+..+..... ......++.++||||+++|+||+++....+......|...... T Consensus 326 ~~~~~~~~~~~c~~~~~---~~~~~~c~~~~~~~~~-~~~~~~~~~~~ydAv~~~a~aL~~~~~~~~~~~~~~c~~~~~~ 401 (555) T 2E4X_B 326 WFRDFWEQKFQCSLQNK---RNHRQVCDKHLAIDSS-NYEQESKIMFVVNAVYAMAHALHKMQRTLCPQTTKLCDAMKIL 401 (555) T ss_dssp THHHHHHHHTTCCSSSS---SSCCCCCCTTCCCCTT-TCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCGGGSSC T ss_pred HHHHHHHHHcCCccCCc---cCCCcccCCCcccCCC-CccchhhHHHHHHHHHHHHHHHHHHHhccCCCCCCCchhhccc Confidence 67777777666532110 0011123322111100 0122345678999999999999998764332111122211111 Q NP_000836.2 438 DGKE-LLGYIRAVNFN-------GSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREH 509 (908) Q Consensus 438 ~~~~-l~~~l~~~~f~-------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~~~ 509 (908) ++.. +.+.|++..|. |.+| .+.||++|++...|.|++++..++...++.||.|+....++...+.|.++ T Consensus 402 ~~~~~~~~~l~~~~f~~~~~~~~g~~g-~v~fd~~G~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~i~W~~~-- 478 (555) T 2E4X_B 402 DGKKLYKEYLLKIQFTAPFNPNKGADS-IVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRN-- 478 (555) T ss_dssp CHHHHHHHHTTCCEECTTTSCCSSSCC-EECCCSSSCCCCCEEEEEEECTTSSCEEEEEEEESSSEECCGGGCCCGGG-- T ss_pred ChhHHHHHHHHhCcccCCCCCCCCCCC-eeEeCCCCCCCceEEEEEEEeeCCeEEEEEEEEeCCcEEEecccccccCC-- Confidence 2232 44677777773 6677 89999999998889999887432223688999998654344346889753 Q NP_000836.2 510 THPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWA 584 (908) Q Consensus 510 ~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s~~~~ 584 (908) ..|.++|+.+|++|++|...+++.|||+|..|++++++++.++|.+||.++|||.+++.|.+++..|+.|.+++. T Consensus 479 ~~P~s~Cs~~C~~G~~k~~~~~~~Cc~~C~~C~~~~~~~~~~~C~~Cp~~~~~n~~~~~C~~~~~~~L~~~~~~~ 553 (555) T 2E4X_B 479 SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDALV 553 (555) T ss_dssp SCCCCCSSCCCCSSSCEEECCSSSSCCEEECCCTTEEEEETTEEEECCTTEEECTTSSSEEECCC---------- T ss_pred CCCcceeeCCCCCCceeecCCCCcccceeeecccceeecCceeecCCCCCcccCCCCCCeEeccccccCcccCCC Confidence 568999999999999988766678999999999999998789999999999999999999999999999887653 No 11 >6N50_A Metabotropic glutamate receptor 5, Nanobody; Cell Surface Receptor, SIGNALING PROTEIN; HET: NAG, QUS; 3.751A {Homo sapiens} Probab=100.00 E-value=4.1e-43 Score=405.56 Aligned_cols=536 Identities=41% Similarity=0.786 Sum_probs=353.0 Template_Neff=10.900 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTY 111 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~ 111 (908) .......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++++.|+++++.. T Consensus 42 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~cg~~~~~~g~~~~~a~~~Ai~~iN~~~~~l~~~~l~~~i~D~~~~~~~ 121 (596) T 6N50_A 42 RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAV 121 (596) T ss_pred cceeeEcCCCEEEEEEeecccCCCCCCCCcCCcccccccccHHHHHHHHHHHHHHHcCCCCCCCCeeEEEEEeCCCCHHH Confidence 334456789999999999985311 1234553222356778899999999999998888899999999999887655 Q NP_000836.2 112 ALEQSLTFVQALIEKD---ASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 112 a~~~~~~~~~~l~~~~---~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) +.+.+.+++....... .....|.+.++.+....++++++||+.++..+..++.++...++|+|++++.++.++++.. T Consensus 122 a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~ls~~~~ 201 (596) T 6N50_A 122 ALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTL 201 (596) T ss_pred HHHHHHHHHhcCCCCccccccceecCCCCccccccCCCeeEEECCCChHHHHHHHHHHHHhCCCeeeccCCChhhCCCCC Confidence 5444444432100000 0000000000000011257889999988877778888899999999999887777666556 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++|+.+++++....+.+++.+++. ++++.....+.......++...+++ T Consensus 202 ~~~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~ 280 (596) T 6N50_A 202 FKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLKK 280 (596) T ss_pred CCcccccCCCHHHHHHHHHHHHHHhCCCEEEEEEecCccchHHHHHHHHHHHHC-CcEEEEEEEeCCCCCccchHHHHHH Confidence 899999999999999999999998999999999988788888888888888775 4666543322211122345566676 Q NP_000836.2 269 LLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) +++ ..+.++|++......+..+++++.+.|+.+++.|++.+.|...............+.+.+.......++|..|+.. T Consensus 281 i~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~I~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~f~~~ 360 (596) T 6N50_A 281 LTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLK 360 (596) T ss_pred HHHcCCCcEEEEEECCHHHHHHHHHHHHHcCCCCCEEEEEecCccccccccCCCccccccccccCCCCCCCCCHHHHHHh Confidence 653 1244555655556667788888888887544667777655432211000111233434443333334445555443 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) ..+...+.+.++.++|++.++|........ ..+...|+....... ......++.++||||+++|+|++++....+.. T Consensus 361 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~ydAV~~~a~al~~~~~~~~~~ 438 (596) T 6N50_A 361 LRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPG 438 (596) T ss_pred cCCCCCCCCHHHHHHHHHHcCCCCCCCccccccCCCCCCCCccccc--CCCCccchHHHHHHHHHHHHHHHHHHhccCCC Confidence 322223345677788877766532210000 001112332211110 01123456789999999999999987543321 Q NP_000836.2 427 YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDMQW 504 (908) Q Consensus 427 ~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i~w 504 (908) ....|......++..+.++|++.+|.|.+|..+.||++|++...|.|++++..+ +...++.||.|+... .++ ..+.| T Consensus 439 ~~~~c~~~~~~~~~~l~~~l~~~~f~g~~G~~v~fd~~G~~~~~y~i~~~~~~~~~~~~~~~VG~~~~~~l~~~-~~i~W 517 (596) T 6N50_A 439 YAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDEVW 517 (596) T ss_pred CCCCCccCCCCCHHHHHHHHhcCceecCCCCeEEeCCCCCCCCCEEEEEEEEcCCCcEEEEEEEEEcCCceEEe-cceec Confidence 111222112235566778899899999888349999999998899999998532 223689999998652 122 13689 Q NP_000836.2 505 AHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIK 576 (908) Q Consensus 505 ~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~ 576 (908) .++ ...|.++|+++|++|++|...++ +.|||+|.+|++++++++.++|.+||.++|||++++.|.+++... T Consensus 518 ~~~-~~~P~s~Cs~~C~~G~~~~~~~~~~~CC~~C~~C~~~~~s~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~ 589 (596) T 6N50_A 518 SKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQH 589 (596) T ss_pred CCC-CCCCCceecCCCCCCceeCCCCCCCCCCcceecCCCCceeCCCCceecCCCCcCCCCCCCCEEEccCCc Confidence 753 36699999999999999988777 789999999999999987799999999999999999998776543 No 12 >6N4Y_C Metabotropic glutamate receptor 5, Nanobody; Cell Surface Receptor Nanobody, MEMBRANE; HET: FUC, MAN, NAG, BMA; 3.262A {Homo sapiens} Probab=100.00 E-value=4.4e-43 Score=405.35 Aligned_cols=536 Identities=41% Similarity=0.786 Sum_probs=309.2 Template_Neff=10.900 Q NP_000836.2 36 YAHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTY 111 (908) Q Consensus 36 ~~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~ 111 (908) .......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++++.|++++... T Consensus 42 ~~~~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~cg~~~~~~g~~~~~a~~~Av~~iN~~~~~l~~~~l~~~i~D~~~~~~~ 121 (596) T 6N4Y_C 42 RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAV 121 (596) T ss_dssp -CCCEEECCSEEEEEEECCBCCCCTTTTTTTCCCSBCCCCCCHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHH T ss_pred CeEEEEecCCEEEEeeeecccCCCccccccCCccccccccCHHHHHHHHHHHHHHhcCCCCCCCCeeeeEEeeCCCCHHH Confidence 334456789999999999985210 1234553222456778899999999999998888899999999999887655 Q NP_000836.2 112 ALEQSLTFVQALIEKD---ASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 112 a~~~~~~~~~~l~~~~---~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) +.+.+.+++....... .....|.+.++.+....++++++||+.++..+..++.++...++|+|++++.++.++++.. T Consensus 122 a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~aviG~~~s~~~~~~~~~~~~~~ip~is~~~~~~~l~~~~~ 201 (596) T 6N4Y_C 122 ALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTL 201 (596) T ss_dssp HHHHHHHHHTGGGC-------------------CCCCCEEEEECCSSHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTTT T ss_pred HHHHHHHHHHHhcCCcccccceeeccCCCcccccCCCCeEEEECCCCcHHHHHHHHHHHHhCCCEEeccCCCcccCCccc Confidence 5444444432100000 0000000000000001257889999988877778888899999999999887777766556 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+.......++...+++ T Consensus 202 ~~~~~r~~p~~~~~~~al~~~l~~~~w~~v~ii~~~~~~g~~~~~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~ 280 (596) T 6N4Y_C 202 FKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKE-GICIAHSYKIYSNAGEQSFDKLLKK 280 (596) T ss_dssp CTTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECTTSHHHHHHHHHHH T ss_pred CCcccccCCCHHHHHHHHHHHHHHcCCCEEEEEEeCCcchHHHHHHHHHHHHHc-CceEEEEEEecccCChHHHHHHHHH Confidence 899999999999999999999988999999999988788888888888888775 4666543322211122345566666 Q NP_000836.2 269 LLE-TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) +++ ..+.++|++......+..+++++.+.|+..++.|++.+.|...............+.+.+.......+.|..|+.. T Consensus 281 i~~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~I~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~fl~~ 360 (596) T 6N4Y_C 281 LTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLK 360 (596) T ss_dssp HHHHTTTCCEEEEECCHHHHHHHHHHHHHTTCTTSCEEEECGGGSSCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHTT T ss_pred HHhcCCCeeEEEEECChHHHHHHHHHHHHhCCCCCEEEEEecccccccccccccccccccceeeeccCCCCccHHHHHHh Confidence 653 1244555655556667788998888887544667777655432211000111223334333333333445555433 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) ..+...+.+.++.++|++.++|........ ......|+....... ......++.++||||+++|+|++++....+.. T Consensus 361 l~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~ydAV~~~a~al~~~~~~~~~~ 438 (596) T 6N4Y_C 361 LRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKT--HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPG 438 (596) T ss_dssp CCTTTCCSCTTHHHHHHHHTTEECTTCTTCCTTCSEECCTTCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHSTT T ss_pred cCcccCCCCHHHHHHHHHHcCCCCCCCCcccccccccCCCcceecc--cccccccHHHHHHHHHHHHHHHHHHHhhhCCC Confidence 322223345677788877666532110000 001112332211110 01123456679999999999999987543321 Q NP_000836.2 427 YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVEDMQW 504 (908) Q Consensus 427 ~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~i~w 504 (908) ....|......++..+.++|++.+|.|.+|..+.||++|++...|.|.+++..+ +...++.||.|+... .++ ..+.| T Consensus 439 ~~~~c~~~~~~~~~~l~~~l~~~~f~g~~G~~v~fd~~G~~~~~y~i~~~~~~~~~~~~~~~VG~~~~~~l~~~-~~i~W 517 (596) T 6N4Y_C 439 YAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD-DDEVW 517 (596) T ss_dssp CSSCCGGGSSCCHHHHHHHHHTCEEECTTSCEEECCTTSCCCCEEEEEEEEEEETTEEEEEEEEEEETTEEEEC-TTC-- T ss_pred CCCCccccCCCCHHHHHHHHhcCeeecCCCCEEEeCCCCCCCcceEEEEEEEcCCCeeEEEEEEEEeCCceEEc-ccccc Confidence 112222112234566778899899999888349999999998899999998532 223689999998652 122 13689 Q NP_000836.2 505 AHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIK 576 (908) Q Consensus 505 ~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~ 576 (908) .++ ...|.++|+.+|++|++|...++ +.|||+|.+|++++++++.++|.+||.++|||++++.|.+++... T Consensus 518 ~~~-~~~P~s~Cs~~C~~G~~k~~~~~~~~CC~~C~~C~~~~~s~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~ 589 (596) T 6N4Y_C 518 SKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQH 589 (596) T ss_dssp -------CCCCSSCCC----CEEECCSSCTTCCEEEC------------------------------------ T ss_pred ccC-CCCcceeecCCCCCCeEEeeeCCCCccccceeecCCCeEecCCceeccCCCCcccCccCCCeEEccCCc Confidence 763 36699999999999999988777 789999999999999987799999999999999999998776543 No 13 >5K5S_B Extracellular calcium-sensing receptor; Venus Flytrap module, cysteine-rich domain; HET: TRP, PO4, NAG; 2.6A {Homo sapiens} Probab=100.00 E-value=1.3e-42 Score=402.94 Aligned_cols=534 Identities=32% Similarity=0.555 Sum_probs=352.3 Template_Neff=10.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGER----------GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSR 108 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~----------~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~ 108 (908) .....++++||+++|.++.... ...|+... ..+.+...|+.+|++++|+++++++|+++++.+.|++++ T Consensus 25 ~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~Av~~iN~~~~~l~~~~l~~~~~D~~~~ 103 (615) T 5K5S_B 25 RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNT 103 (615) T ss_dssp EEEECCSEEEEEEECSBSCBCCCCCCCSSCCCCCCBCSBC-HHHHHHHHHHHHHHHHHHHCSSSCSSCCEEEEEEECTTC T ss_pred ceEecCCEEEEeeeeceecccCCCCCcccCCCcccceeec-cccHHHHHHHHHHHHHHhcCCCCCCCCceeEEEEcCCCC Confidence 3567789999999999874321 12343211 245678899999999999998888999999999999887 Q NP_000836.2 109 DTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 109 ~~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) ...+.+.+.+++... .....+....+.+....+++.++||+.++..+..++.++...++|+|++.+.++.++++.. T Consensus 104 ~~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~iP~is~~~~~~~l~~~~~ 179 (615) T 5K5S_B 104 VSKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179 (615) T ss_dssp HHHHHHHHHHHTTTT----GGGC-------------CCEEEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTT T ss_pred HHHHHHHHHHHHhcC----CccCCCccccccCCCCCCCeEEEEcCCChHHHHHHHHHHcccCCCeEeccccCcccCCccc Confidence 655544444443211 0000000000011111135678999988877778889999999999999887777766557 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+....+..+....+++ T Consensus 180 ~~~~~r~~p~~~~~~~al~~~l~~~~w~~v~iv~~~~~~g~~~~~~l~~~~~~~-gi~i~~~~~~~~~~~~~~~~~~~~~ 258 (615) T 5K5S_B 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEV 258 (615) T ss_dssp CTTEEESSCCTHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHH T ss_pred CCCccccCCChHHHHHHHHHHHHHcCCcEEEEEEEcCccchHHHHHHHHHHHHC-CcEEEEEEeecCCCCHHHHHHHHHH Confidence 899999999999999999999999999999999988788888888888888775 4676543333211122345556666 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++++|++.+....+..+++++.+.|+.+ ..|+..+.|....... ........|.+.+.......++|..|+.. T Consensus 259 l~~-~~~~vvi~~~~~~~~~~~l~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~f~~~ 336 (615) T 5K5S_B 259 IQN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKK 336 (615) T ss_dssp HHT-CCCCEEEEECCHHHHHHHHHHHHHTTCCC-CEEEECTTTTTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHT T ss_pred HHh-CCCeEEEEeCCchhHHHHHHHHHHcCCCC-CEEEEehhHhcchhccCccccceeceEEEEEeecccCccHHHHHHH Confidence 653 57899888877777888888888888753 5788776664432100 00112334555555444455566666544 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR----------------------NSHIKKCTGLERIARD----SSYEQEGK 401 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~c~~~~~~~~~----~~~~~~~~ 401 (908) ..+.....+.++.++|++.+.|........ ..+...|++.+.+... .......+ T Consensus 337 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~~~~~~~~ 416 (615) T 5K5S_B 337 VHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSQSSTAFRPLCTGDENINSVETPYIDYTHLRI 416 (615) T ss_dssp CCTTTCSSBTTHHHHHHHHTTCBC-------------------------------CCBCCTTCCSTTSCCTTTCCSCBSH T ss_pred hCcccCCCChHHHHHHHHHhCCcCCCCCCCCCCchhhccCCcccCCcccCCCCCCCCCCCCCCCcccCCCCccccccccc Confidence 332223345567777777666542210000 0011123322211000 00112245 Q NP_000836.2 402 VQFVIDAVYSMAYALHNMHKDLCPGY---IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQI 478 (908) Q Consensus 402 ~~~~yDAv~~la~Al~~~~~~~~~~~---~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~ 478 (908) +.++||||+++|+||+++..+.+... ...|.......++.+.+.|++.+|.|.+|+.|.||++|++...|.|++++. T Consensus 417 ~~~~ydAV~~~A~aL~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~g~~gg~v~fd~~G~~~~~y~I~~~~~ 496 (615) T 5K5S_B 417 SYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLQFTNNMGEQVTFDECGDLVGNYSIINWHL 496 (615) T ss_dssp HHHHHHHHHHHHHHHHHHHTCCTTSCCBTTTBCCCTTSCCHHHHHHHHHTCEEECTTSCEEECCTTSCCCCCEEEEEEEE T ss_pred hhHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCcccccccChHHHHHHHhcCeeeCCCCCEEEECCCCCCCceEEEEEEEe Confidence 67899999999999999976543210 122221112234457788888899987644899999999988999999874 Q NP_000836.2 479 TN--KSTEYKVIGHWTNQL------HLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQV- 548 (908) Q Consensus 479 ~~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~- 548 (908) .+ +...++.||.|+... .++...+.|.++...+|.++|+.+|++|+++...++ +.|||+|.+|+++++++ T Consensus 497 ~~~~~~~~~~~Vg~~~~~~~~~~~l~~~~~~i~W~~~~~~~P~s~Cs~~C~~G~~~~~~~~~~~CC~~C~~C~~~~~s~~ 576 (615) T 5K5S_B 497 SPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDE 576 (615) T ss_dssp CTTTCSEEEEEEEEECSSSCTTSSEEECGGGCCBTTTBCSCCCCCSSCCCCTTEEEEECSSSCTTCEEEEECCTTEECCS T ss_pred CCCCCCEEEEEEEEEEeecCCCCeEEEehhheecCCCCCCCCeeeecCCCCcCceecccCCCCcccceeeeCCCCcEECC Confidence 31 123588999998532 123335789864456699999999999999877666 68999999999999997 Q NP_000836.2 549 -DELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 549 -~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +.++|.+||.++|||++++.|.+++..|+.|. T Consensus 577 ~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~l~~~ 609 (615) T 5K5S_B 577 TDASACNKCPDDFWSNENHTSCIAKEIEFLSDY 609 (615) T ss_dssp TTCSSCEECCTTEEECTTSSSEEETC------- T ss_pred CCcccccCCCCCceecCCCCcEEecEEEeeccC Confidence 57999999999999999999999988888776 No 14 >5KZQ_A Metabotropic glutamate receptor 2; mGluR2, antagonist, antidepressent, SIGNALING PROTEIN; HET: NAG, 6YS; 2.8A {Homo sapiens} Probab=100.00 E-value=1.7e-42 Score=398.18 Aligned_cols=529 Identities=44% Similarity=0.837 Sum_probs=347.9 Template_Neff=11.000 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....+++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++++.|++++...+.+.+. T Consensus 24 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~Ai~~iN~~~~~l~~~~l~~~~~D~~~~~~~a~~~~~ 103 (570) T 5KZQ_A 24 KVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQAL 103 (570) T ss_pred cceEecCCEEEEEeeehhccCCCccccccccCCccHHHHHHHHHHHHHHhcCCCCCCCCeeEEEEEeCCCCHHHHHHHHH Confidence 34677889999999999832211224443222345678899999999999988888999999999999877554444444 Q NP_000836.2 118 TFVQALIEKD--ASDVKCANGDPPIFTK-PDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 118 ~~~~~l~~~~--~~~~~~~~~~~~~~~~-~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) +++....... .....|...++.+... .++++++||+.++..+..++.++..+++|+|++.+.++.++++..++++++ T Consensus 104 ~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~a~~~~~~~ip~is~~~~~~~ls~~~~~~~~~r 183 (570) T 5KZQ_A 104 DFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183 (570) T ss_pred HHHhcccCCCCCCCceecCCCCcccCCCCCCCceEEECCCChHHHHHHHHHhhhhCCCeeecCCCChhhCCcccCCccee Confidence 4432100000 0000000000000000 136889999988877778888999999999999887777766556899999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.|++..+++++++++++++|++|++|++++.++....+.+++.+++. ++++.....++......++...+++++...+ T Consensus 184 ~~p~~~~~~~al~~~l~~~~w~~v~il~~~~~~g~~~~~~~~~~~~~~-~i~i~~~~~~~~~~~~~~~~~~~~~l~~~~~ 262 (570) T 5KZQ_A 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NICVATSEKVGRAMSRAAFEGVVRALLQKPS 262 (570) T ss_pred cCCChHHHHHHHHHHHHHhCCcEEEEEEecChhhHHHHHHHHHHHHHc-CcEEEEEEEcCCCCCCcccHHHHHHHHHhCC Confidence 999999999999999999999999999988788888888888887775 4666543333211122345555666642247 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) +++|++......+..+++++++.|+ ++.|++.+.|...............|.+.+.......++|..|+....+...+ T Consensus 263 ~~viv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~~~~~~~~~~~~ 340 (570) T 5KZQ_A 263 ARVAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNS 340 (570) T ss_pred cEEEEEECCHHHHHHHHHHHHHhCC--CeEEEEeCcccCChhHHhcchhHhceEEEEecCCCCCCcHHHHHHhcCCCCCC Confidence 8888887776677888888888776 46788776554322110001123344444433333333444443322222223 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) .+.++.++|++.+.|.... ..|+.. ..... ......++.++||||+++++|++++....+......|... T Consensus 341 ~~~~~~~~~~~~~~c~~~~--------~~c~~~-~~~~~-~~~~~~~~~~~ydAv~~~a~al~~~~~~~~~~~~~~c~~~ 410 (570) T 5KZQ_A 341 RNPWFREFWEQRFRCSFRQ--------RDCAAH-SLRAV-PFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAM 410 (570) T ss_pred CCHHHHHHHHHHcCCCCCC--------CCCCCC-CcccC-CCCCCcchHHHHHHHHHHHHHHHHHHhccCCCCCCCcccc Confidence 4556777777666553210 011110 00000 0112345678999999999999998764332211223221 Q NP_000836.2 435 STIDGKEL-LGYIRAVNFNG------SAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 435 ~~~~~~~l-~~~l~~~~f~G------~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) ...++.++ .+.+++..|.+ .+| .+.||++|++...|.|++++..+ +...++.||.|+....++...+.|++ T Consensus 411 ~~~~~~~l~~~~l~~~~f~~~~~~~~~~g-~v~fd~~G~~~~~y~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~i~W~~ 489 (570) T 5KZQ_A 411 RPVNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 489 (570) T ss_pred CcCChhHHHHhhhhceeecCCCCCCCCCC-EEEeCCCCCCCccEEEEEEEEcCCCCeeEEEEEEECCCCccccccccCCC Confidence 11234443 35577777763 566 89999999998889998887432 12368899999865444434678976 Q NP_000836.2 507 RE-HTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 507 ~~-~~~p~s~Cs~~c~~G~~k~~~~~~~Cc~~c~~C~~~~~~~~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +. .+.|.++|++.|++|+++...+++.|||+|.+|++|+++++.++|.+||.++|||++++.|.+++..|+.+. T Consensus 490 ~~~~~~~~s~C~~~C~~g~~~~~~~~~~CC~~C~~C~~g~~~~~~~~C~~Cp~~~~~n~~~~~C~~~~~~~l~~~ 564 (570) T 5KZQ_A 490 PSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIREG 564 (570) T ss_pred CCCCCCCceeecCCCCCCceeCCCCCCccccccccCCCCeeecCccccccCCCccccCCCCCCeEecceehhccC Confidence 42 345889999999999998766567899999999999999988999999999999999999999888887664 No 15 >5K5T_A Extracellular calcium-sensing receptor; Venus Flytrap module, cysteine rich; HET: NAG, SO4; 3.1A {Homo sapiens} Probab=100.00 E-value=2.4e-42 Score=400.86 Aligned_cols=534 Identities=32% Similarity=0.559 Sum_probs=355.1 Template_Neff=11.000 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGER----------GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSR 108 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~----------~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~ 108 (908) ....+++++||+++|.++.... ...|+.. ...+.....|+++|++++|+++++++|+++++.+.|++++ T Consensus 25 ~~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~-~~~~~~~~~a~~~Av~~iN~~~~llp~~~l~~~~~D~~~~ 103 (615) T 5K5T_A 25 RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRY-NFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNT 103 (615) T ss_dssp CEEECCSEEEEEEECSBSCBCCCCCCCSSCCCCCCBCSB-CHHHHHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTC T ss_pred ceEecCCEEEEeeeeeeecccCCCCCcccCCCcccceee-ccccHHHHHHHHHHHHHHhcCCCCCCCCceeEEEEcCCCC Confidence 4567789999999999864321 1234321 1245678899999999999998888999999999999887 Q NP_000836.2 109 DTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188 (908) Q Consensus 109 ~~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~ 188 (908) ...+.+.+.+++... .....+....+.+.....++.++||+.++..+..++.++..+++|+|++.+.++.++++.. T Consensus 104 ~~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~a~~~~~~~ip~is~~~~~~~l~~~~~ 179 (615) T 5K5T_A 104 VSKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179 (615) T ss_dssp HHHHHHHHHHHHCCC----CCHHHSGGGGCC-----CCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTT T ss_pred HHHHHHHHHHHHhcC----CccCCCccccccCCCCCCCeEEEEcCCChHHHHHHHHHhcccCCCeEeccccCcccCCccc Confidence 655444444443210 0000000000011111135678999988877778888999999999999887777766556 Q NP_000836.2 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 189 ~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) +++++++.|++..++.++++++++++|++|++++.+++++....+.|++.+++. ++++.....+....+..++...+++ T Consensus 180 ~~~~~~~~p~~~~~~~al~~~l~~~~w~~v~vl~~~~~~g~~~~~~~~~~~~~~-gi~v~~~~~~~~~~~~~~~~~~~~~ 258 (615) T 5K5T_A 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEV 258 (615) T ss_dssp CTTEEESSCCTTHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHH T ss_pred CCcccccCCChHHHHHHHHHHHHHcCCcEEEEEEecCcccchHHHHHHHHHHHC-CcEEEEEEeecCCCCHHHHHHHHHH Confidence 899999999999999999999999999999999988888888888888888775 4776544333211122345556666 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++++|++......+..+++++.+.++.+ ..|+..+.|....... ........|.+.+.......++|..|+.. T Consensus 259 i~~-~~~~viv~~~~~~~~~~~l~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~l~~~~~~~~~~~f~~f~~~ 336 (615) T 5K5T_A 259 IQN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKK 336 (615) T ss_dssp HHH-CCCCEEEEECCHHHHHHHHHHHHHHTCCC-CEEEECHHHHTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHT T ss_pred HHh-CCCeEEEEeCCchhHHHHHHHHHHcCCCC-CEEEEehhHhcchhccCccccceeceEEEEEeccccCccHHHHHHH Confidence 663 57899988877777888888888888753 5788777665432110 00112344555555444445566666544 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKR----------------------NSHIKKCTGLERIARD----SSYEQEGK 401 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~c~~~~~~~~~----~~~~~~~~ 401 (908) ..+.....+.++.++|+..+.|........ ..+...|++.+.+... .......+ T Consensus 337 l~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~C~~~~~~~~~~~~~~~~~~~~~ 416 (615) T 5K5T_A 337 VHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSQSSTAFRPLCTGDENINSVETPYIDYTHLRI 416 (615) T ss_dssp CCTTTCSSBTHHHHHHHHHHTSEECSSCCSCCCSCTTGGGGGSTTCCSSSGGGTCCCEECSCCCTTTSCCTTTCCSCBSH T ss_pred hCcccCCCChHHHHHHHHHhCCcCCCCCCCCCCchhhccCCcccCCcccCCCCCCCCCCCCCCCcccCCCCccccccccc Confidence 332223344566777777666542210000 0011123322211100 00112345 Q NP_000836.2 402 VQFVIDAVYSMAYALHNMHKDLCPG---YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQI 478 (908) Q Consensus 402 ~~~~yDAv~~la~Al~~~~~~~~~~---~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~ 478 (908) +.++||||+++|+||+++..+.+.. ....|.......++.+.+.|++.+|.|.+|+.|.||++|++...|.|++++. T Consensus 417 ~~~~ydAV~~~A~aL~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~g~~G~~v~fd~~Gd~~~~y~I~~~~~ 496 (615) T 5K5T_A 417 SYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHL 496 (615) T ss_dssp HHHHHHHHHHHHHHHHHHHHCCTTSBTBTTBBCCCSTTCCHHHHHHHHHSCEEECTTSCEEEBCSSSBBCCEEEEEEEEE T ss_pred hhHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCCccccccCHHHHHHHHhhCeEECCCCCEEEeCCCCCCCceEEEEEEEe Confidence 6789999999999999987654321 0122222112334557788888899988776799999999988999999874 Q NP_000836.2 479 TN--KSTEYKVIGHWTNQL------HLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQV- 548 (908) Q Consensus 479 ~~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~~~~~p~s~Cs~~c~~G~~k~~~~~-~~Cc~~c~~C~~~~~~~- 548 (908) .. +...++.||.|+... .++...+.|.++...+|.++|+.+|++|+++...++ +.|||+|.+|+++++++ T Consensus 497 ~~~~~~~~~~~Vg~~~~~~~~~~~l~~~~~~i~W~~~~~~~P~s~Cs~~C~~G~~~~~~~~~~~Cc~~C~~C~~~~~s~~ 576 (615) T 5K5T_A 497 SPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDE 576 (615) T ss_dssp CTTTCSEEEEEEEEEESSSCTTSSEEECGGGCCBTTTBCSCCCCCSSCCCCTTEEEEECSSSCTTCEEEEECCTTEECCS T ss_pred CCCCCCEEEEEEEEEEeecCCCCeEEEeccceecCCCCCCCCeeeecCCCCcCceecccCCCCcccceeeeCCCCcEECC Confidence 31 123588999998542 123335789764446699999999999999877666 68999999999999997 Q NP_000836.2 549 -DELSCELCPLDQRPNMNRTGCQLIPIIKLEWH 580 (908) Q Consensus 549 -~~~~C~~cp~~~~~~~~~~~c~~~~~~~~~~s 580 (908) +.++|.+||.++|||++++.|.+++..|+.|+ T Consensus 577 ~~~~~C~~Cp~~~~~n~~~t~C~~~~~~~l~~~ 609 (615) T 5K5T_A 577 TDASACNKCPDDFWSNENHTSCIAKEIEFLSDY 609 (615) T ss_dssp SSCSSCEECCTTEEECTTSSSEEECCC------ T ss_pred CCcccccCCCCCceecCCCCcEEecEEEeecCC Confidence 57999999999999999999999988888776 No 16 >6FFH_A Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate; 7TM, RECEPTOR, GPCR, MEMBRANE-PROTEIN, SIGNALING; HET: D7W, OLC, YCM, MES, OLA; 2.65A {Homo sapiens} Probab=100.00 E-value=9.6e-38 Score=308.98 Aligned_cols=266 Identities=48% Similarity=0.851 Sum_probs=223.2 Template_Neff=4.100 Q NP_000836.2 573 PIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRR 652 (908) Q Consensus 573 ~~~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~ 652 (908) +.++..+++++.+++.+++++|++++++++++++++|+++++|.+++.+++++|+|+.++|+++++++..|+...|.+|. T Consensus 4 PveyLs~S~~~~i~llaLSaIGILitLiiLIIfI~~RsTPvIk~ssp~L~~~iLLG~~l~~~~~~~~~~~p~~~~C~lR~ 83 (444) T 6FFH_A 4 PVQYLRWGDPAPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFXLIAKPKQIYCYLQR 83 (444) T ss_dssp HHHHHHTTCCHHHHHHHHHHHHHHHHHHHHHHHHHTTTSHHHHHSCHHHHHHHHHHHHHHHHTHHHHBSCSCHHHHHHHH T ss_pred cceeccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCchhhcCCHHHHHHHHHHHHHHHHHHHHhccCCchhHHHHHH Confidence 45677889999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 653 VFLGLGMCFSYAALLTKTNRIHRIFEQGKKSV---------TAP------------------------------------ 687 (908) Q Consensus 653 ~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~---------~~~------------------------------------ 687 (908) |++++||+++||++++|+||++++|..++++. .++ T Consensus 84 ~~l~lgfsl~~~~l~vKt~RI~~if~~~~~~~~~~~~~~~~~~~~~i~d~~l~~~v~~~~l~~~~~~~~~~~~~~d~~~~ 163 (444) T 6FFH_A 84 IGIGLSPAMSYSALVTKTYRAARILAMSKKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG 163 (444) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHTCCEEEEEECTTSCEEEETTEEEESSSCHHHHHHHHHHHHS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhccccChhhhhhcccccceeeecCcchhhhhhhhHHhcCCcccchhhhhhhhhcc Confidence 99999999999999999999999998664320 000 Q NP_000836.2 688 -------------------------------------------------------------------------------- 687 (908) Q Consensus 688 -------------------------------------------------------------------------------- 687 (908) T Consensus 164 ~~~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 243 (444) T 6FFH_A 164 RNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAV 243 (444) T ss_dssp SCCTTBCCHHHHHHHHHHHHHHHHHHHHTCTTTHHHHHHSCHHHHHHHHHHHHHHCHHHHTTCHHHHHHHHTTCHHHHHH T ss_pred cCCCCccchhHHHHHhcCchhHHHHHhHhccCCCccccchhHHHHHHHHHhhhccCcccccccchhHHHHHHhchhHHHH Confidence Q NP_000836.2 688 -------------------------------------KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT 730 (908) Q Consensus 688 -------------------------------------~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~ 730 (908) ++.+.+.++.++++++.+|+++++.|...+|+........ T Consensus 244 ~~~~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~iq~~i~~~~~~~~pp~~~~~~~~--- 320 (444) T 6FFH_A 244 NLAKSRWYNQTPNRAKRVITTFRTGTWDAYKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS--- 320 (444) T ss_dssp HHTTSHHHHHSHHHHHHHHHHHHHSSSTTSCC--------CHHHHHHHHHHHHHHHHHHHHHHHHHSCCCBSSSCC---- T ss_pred hhhhcccccCCCCccceeeeeeecCCccchhhccCCcccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCccCCcc--- Confidence 0112233455566677899999999999998876543211 Q NP_000836.2 731 LDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEK 810 (908) Q Consensus 731 ~~~~~~~~~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 810 (908) .......|...+.++++.++|+++|+++|+++|+++|++|++|||+|+|++++|+.+++|+++.|+++..... T Consensus 321 ----~~~~~~~C~~~~~~~~~~l~y~~iLll~~~~~A~~tR~vp~~fnEak~I~~~~y~~~ii~~~~~p~~~~~~~~--- 393 (444) T 6FFH_A 321 ----IREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--- 393 (444) T ss_dssp ------CCBCCBCCCHHHHHHHHHHHHHHHHHHHHHHHHTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCSCH--- T ss_pred ----cceEEEeecCCChHHHHHHHHHHHHHHHHHHHHHHhcCCchhhhHHHHHHHHHHHHHHHHHHHHHHHHcCCcH--- Confidence 2345679998777778899999999999999999999999999999999999999999999999998876533 Q NP_000836.2 811 MYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 811 ~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) +.+.++++++++++.++++|+||+|.++++||++.+.. T Consensus 394 ----~~~~~~~i~l~~t~~l~~iF~PK~~~I~~~p~~n~~~~ 431 (444) T 6FFH_A 394 ----IITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSA 431 (444) T ss_dssp ----HHHHHHHHHHHHHHHHHHHTHHHHHHHHHCTTTC---- T ss_pred ----HHHHHHHHHHHHHHHHHHHHHHHHHHHHcCcccchHHH Confidence 23677899999999999999999999999999887653 No 17 >6FFI_A Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate; 7TM, RECEPTOR, GPCR, MEMBRANE-PROTEIN, SIGNALING; HET: YCM, MES, OLA, D8B; 2.2A {Homo sapiens} Probab=100.00 E-value=9.6e-38 Score=308.98 Aligned_cols=266 Identities=48% Similarity=0.851 Sum_probs=222.1 Template_Neff=4.100 Q NP_000836.2 573 PIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRR 652 (908) Q Consensus 573 ~~~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~~~~ 652 (908) +.++..+++++.+++.+++++|++++++++++++++|+++++|.+++.+++++|+|+.++|+++++++..|+...|.+|. T Consensus 4 PveyLs~S~~~~i~llaLSaIGILitLiiLIIfI~~RsTPvIk~ssp~L~~~iLLG~~l~~~~~~~~~~~p~~~~C~lR~ 83 (444) T 6FFI_A 4 PVQYLRWGDPAPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFXLIAKPKQIYCYLQR 83 (444) T ss_dssp HHHHHHTTCCHHHHHHHHHHHHHHHHHHHHHHHHHGGGSHHHHSSCHHHHHHHHHHHHHHHHTHHHHBCCSCHHHHHHHH T ss_pred cceeccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCchhhcCCHHHHHHHHHHHHHHHHHHHHhccCCchhHHHHHH Confidence 45677889999999999999999999999999999999999999999999999999999999999999999999999999 Q NP_000836.2 653 VFLGLGMCFSYAALLTKTNRIHRIFEQGKKSV---------TAP------------------------------------ 687 (908) Q Consensus 653 ~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~---------~~~------------------------------------ 687 (908) |++++||+++||++++|+||++++|..++++. .++ T Consensus 84 ~~l~lgfsl~~~~l~vKt~RI~~if~~~~~~~~~~~~~~~~~~~~~i~d~~l~~~v~~~~l~~~~~~~~~~~~~~d~~~~ 163 (444) T 6FFI_A 84 IGIGLSPAMSYSALVTKTYRAARILAMSKKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG 163 (444) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCEEEEEECTTCCEEEETTEECCCSSCHHHHHHHHHHHHS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhccccChhhhhhcccccceeeecCcchhhhhhhhHHhcCCcccchhhhhhhhhcc Confidence 99999999999999999999999998664320 000 Q NP_000836.2 688 -------------------------------------------------------------------------------- 687 (908) Q Consensus 688 -------------------------------------------------------------------------------- 687 (908) T Consensus 164 ~~~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 243 (444) T 6FFI_A 164 RNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAV 243 (444) T ss_dssp SCCTTBCCHHHHHHHHHHHHHHHHHHHHTCTTTHHHHHHSCHHHHHHHHHHHHHHHHHHHTTCHHHHHHHHTTCHHHHHH T ss_pred cCCCCccchhHHHHHhcCchhHHHHHhHhccCCCccccchhHHHHHHHHHhhhccCcccccccchhHHHHHHhchhHHHH Confidence Q NP_000836.2 688 -------------------------------------KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRT 730 (908) Q Consensus 688 -------------------------------------~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~~~~ 730 (908) ++.+.+.++.++++++.+|+++++.|...+|+........ T Consensus 244 ~~~~~~w~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~iq~~i~~~~~~~~pp~~~~~~~~--- 320 (444) T 6FFI_A 244 NLAKSRWYNQTPNRAKRVITTFRTGTWDAYKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPS--- 320 (444) T ss_dssp HHTTSHHHHHSHHHHHHHHHHHHHSSSTTSCC--------CHHHHHHHHHHHHHHHHHHHHHHHHHSCCCBC-------- T ss_pred hhhhcccccCCCCccceeeeeeecCCccchhhccCCcccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCccCCcc--- Confidence 0112233455566677899999999999998876543211 Q NP_000836.2 731 LDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEK 810 (908) Q Consensus 731 ~~~~~~~~~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 810 (908) .......|...+.++++.++|+++|+++|+++|+++|++|++|||+|+|++++|+.+++|+++.|+++..... T Consensus 321 ----~~~~~~~C~~~~~~~~~~l~y~~iLll~~~~~A~~tR~vp~~fnEak~I~~~~y~~~ii~~~~~p~~~~~~~~--- 393 (444) T 6FFI_A 321 ----IREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--- 393 (444) T ss_dssp ------CCBCCBCCCHHHHHHHHHHHHHHHHHHHHHHHHTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCSCH--- T ss_pred ----cceEEEeecCCChHHHHHHHHHHHHHHHHHHHHHHhcCCchhhhHHHHHHHHHHHHHHHHHHHHHHHHcCCcH--- Confidence 2345679998777778899999999999999999999999999999999999999999999999998876533 Q NP_000836.2 811 MYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKR 852 (908) Q Consensus 811 ~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~ 852 (908) +.+.++++++++++.++++|+||+|.++++||++.+.. T Consensus 394 ----~~~~~~~i~l~~t~~l~~iF~PK~~~I~~~p~~n~~~~ 431 (444) T 6FFI_A 394 ----IITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSA 431 (444) T ss_dssp ----HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCTTTC---- T ss_pred ----HHHHHHHHHHHHHHHHHHHHHHHHHHHHcCcccchHHH Confidence 23677899999999999999999999999999887653 No 18 >4OR2_B Chimera of Soluble cytochrome b562; Human metabotropic glutamate receptor 1; HET: PO4, OLC, OLA, CLR, FM9; 2.8A {Escherichia coli, Homo sapiens} Probab=100.00 E-value=1.8e-37 Score=330.24 Aligned_cols=271 Identities=46% Similarity=0.820 Sum_probs=228.1 Template_Neff=8.400 Q NP_000836.2 570 QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICS 649 (908) Q Consensus 570 ~~~~~~~~~~s~~~~~~~~~~~~~~i~~~~~~~~~~~~~r~~~~i~~s~~~~~~~~l~G~~l~~~~~~~~~~~~~~~~C~ 649 (908) .+.+..+.+++++..+++.+++++|++++++++++++++|+++.+|+++|.++.++++|++++|++++++..+|++..|. T Consensus 108 ~~~p~~~l~~~~~~~i~~~~l~~lgil~~l~~~~~~~~~R~~~vIk~ss~~l~~liL~G~~l~~~s~~~~~~~ps~~~C~ 187 (389) T 4OR2_B 108 YLIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCY 187 (389) T ss_dssp GTSCCBCCCTTSHHHHHHHHHHHHHHHHHHHHHHHHHHTSSSHHHHTSCHHHHHHHHHHHHHHHHHHHHHHSCCCHHHHH T ss_pred ccCcccccCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHcCCChhhhcCCHHHHHHHHHHHHHHHHHHHHhcCCCchhcHh Confidence 33355677888999999999999999999988999999999999999999999999999999999999999899999999 Q NP_000836.2 650 FRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSV--TAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGE 727 (908) Q Consensus 650 ~~~~~~~~gf~l~~~~l~~K~~ri~~if~~~~~~~--~~~~~~~~~~l~~~~~~~~~i~~~i~~~w~~~~p~~~~~~~~~ 727 (908) +|.|++++||+++||++++|+||++++|++++++. +.++..+++.++..++++++++++++++|+..+|+.+...... T Consensus 188 ~r~~~~~lgf~l~~g~l~~Kt~Ri~~iF~~~~~~~~~~~~~~~~~~~~~~~~~~l~~i~~iil~~w~~~~p~~~~~~~~~ 267 (389) T 4OR2_B 188 LQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPS 267 (389) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC-----CCCCCSSCSHHHHHHHHHHHHHHHHHHHHHHHHHSCCCEEEECCS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCcCCCcccCCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCeecCCC Confidence 99999999999999999999999999998765421 1234566777777788888999999999999999887543211 Q NP_000836.2 728 QRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807 (908) Q Consensus 728 ~~~~~~~~~~~~~~C~~~~~~~~~~~~~~~~ll~~~~~la~~~R~~~~~~nes~~i~~~~~~~~~~~~~~~~~~~~~~~~ 807 (908) .......|++.+.++.+.++|+++|++++++|||++|++|++|||+|+|++++|+++++|+++.|+++..+. T Consensus 268 -------~~~~~~~C~~~~~~~~~~~~y~~lLl~~~~~LA~~tR~~~~~~nEsk~i~~~iy~~~~~~~i~~p~~~~~~~- 339 (389) T 4OR2_B 268 -------IKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNY- 339 (389) T ss_dssp -------SSCCEEEECCCSHHHHHHHHHHHHHHHHHHHHHHHTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSC- T ss_pred -------CceEEEecCCCcHHHHHHHHHHHHHHHHHHHHHHHhcCCCcccCHHHHHHHHHHHHHHHHHHHHHHHhCCCH- Confidence 123456899876667788999999999999999999999999999999999999999999999999875432 Q NP_000836.2 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKR 854 (908) Q Consensus 808 ~~~~~~~~~~~~~~i~~~~~~~l~~~f~PK~~~i~~~~~~~~~~~~~ 854 (908) .+.+.+++++++++++++++|+||++.++++|+++.+++.+ T Consensus 340 ------~~~~~~~~il~~~~~~l~~lF~PK~~~i~~~~~~~~~~~~~ 380 (389) T 4OR2_B 340 ------KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFT 380 (389) T ss_dssp ------HHHHHHHHHHHHHHHHCCCCCHHHHHHHHTCHHHHC----- T ss_pred ------HHHHHHHHHHHHHHHHHHHHHccceeEEeeCcccchhhhhh Confidence 23467788899999999999999999999999998876544 No 19 >6BT5_B Metabotropic glutamate receptor 8; mGluR8, GRM8, L-AP4, GENE ID:; HET: NAG, E7P; 2.92A {Homo sapiens} Probab=99.87 E-value=2.3e-27 Score=265.12 Aligned_cols=468 Identities=100% Similarity=1.505 Sum_probs=271.7 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|+++.......|+......+.....|+++|++++|+++++++|.++++.+.|++.++..+.+.+... T Consensus 4 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~iN~~~~~~~~~~l~~~~~d~~~~~~~~~~~~~~~ 83 (479) T 6BT5_B 4 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 83 (479) T ss_dssp EEECCSEEEEEEECCEEECSSSCSEEEECCCCCCCHHHHHHHHHHHHHHCSSTTTTCCEEEEEEECTTCHHHHHHHHGGG T ss_pred eeeCCCEEEEEEEeccccCCCCCCCCcccccccHHHHHHHHHHHHHHhcCCCcCCCCeEeeEEecCCCCHHHHHHHHHHH Confidence 35567899999999987543223454432235677889999999999998887778899999999877643323333444 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++.+...+..|...........++++++||+.++..+..++.++...++|+|++.+..+.+.+...+++++++.++. T Consensus 84 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~~~ 163 (479) T 6BT5_B 84 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 163 (479) T ss_dssp CC------------------------CEEEEECCSSHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTTTCTTEEESSCCH T ss_pred HHHHHhccccccccCCCCCCccCCCCceEEEEcCCCchHHHHHHHHHHHhCCCEEecCCCCcccCCcccccceeecCCCh Confidence 44433210000000000000000013788999998887777888999999999999887666554433578899999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...+.++++++.+++|+++++++.++.++....+.+++.+++.+++++.....+.......++...++++++..++++|+ T Consensus 164 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~iv 243 (479) T 6BT5_B 164 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 243 (479) T ss_dssp HHHHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHHHCSSCEEEEEEEECSSCCTTHHHHHHHHHTTSTTCCEEE T ss_pred HHHHHHHHHHHHHhCCCEEEEEEEcCcchHHHHHHHHHHHHHhCCeEEEEEEecCCCCCcchHHHHHHHHHhCCCCcEEE Confidence 88999999999888999999999777778777888887776642244443222221112234556666665224788888 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) +......+..+++++++.|+..++.|++.+.|...............+.+.+.+.......+..++........+...++ T Consensus 244 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~f 323 (479) T 6BT5_B 244 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 323 (479) T ss_dssp EECCHHHHHHHHHHHHHTTCTTTCEEEECTTTTTCSTTTTTCTTTTTTCEEEEESCCCCHHHHHHHHTCCTTTCCSCTTH T ss_pred EeCCHHHHHHHHHHHHHhCCCCCeEEEEeccccCCCcchhcccchhceeEEEeccccCCCcHHHHHHcCCcccCCCCHHH Confidence 87777778889999998887534567766544322110000111223333222211111122222111100111223445 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 439 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~ 439 (908) .++|++.+++..............|+..+............++..+|||+++++.|++++....+......|......++ T Consensus 324 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDav~~l~~al~~~~~~~~~~~~~~c~~~~~~~~ 403 (479) T 6BT5_B 324 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 403 (479) T ss_dssp HHHHHHHHTCCC-----------CCCSCCCBTTTBCCCCCTTHHHHHHHHHHHHHHHHHHHHHHSSSCSSCCGGGSSCCH T ss_pred HHHHHHHhCCcccCCCccccccccccccchhcCCccccccccHHHHHHHHHHHHHHHHHHHHhhCCCCCCCChhhccCCH Confidence 56666555432110000000011222211100000011234677899999999999998865432211122322122345 Q NP_000836.2 440 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 440 ~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) ..+.+.|++..|.|.+|.+++||++|++...+.+++++..+....++.||.|+....+....+.|+++ T Consensus 404 ~~l~~~l~~~~f~G~tG~~~~f~~~g~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~~ 471 (479) T 6BT5_B 404 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 471 (479) T ss_dssp HHHHHHHHTCEEECTTSSEEECCSSSCCCCEEEEEEEEEETTEEEEEEEEEEESSEEECGGGCCC--- T ss_pred HHHHHHHHhCceecCCCCeeEeCCCCCCCCcEEEEEEEEeCCceeEEEEEEEecceeecHHheeeccc Confidence 56778888889999877469999999988888888887432123578899999765554456788754 No 20 >6BSZ_A Metabotropic glutamate receptor 8; mGluR8, GRM8, glutamate, GENE ID:; HET: GGL, NAG, SO4; 2.65A {Homo sapiens} Probab=99.86 E-value=3.3e-27 Score=263.84 Aligned_cols=468 Identities=100% Similarity=1.503 Sum_probs=273.7 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|++++++++.++++.+.|++.+...+.+.+.+. T Consensus 4 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~iN~~~~~~~~~~l~~~~~d~~~~~~~~~~~~~~~ 83 (479) T 6BSZ_A 4 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 83 (479) T ss_dssp EEECCSEEEEEEECCEEECSTTCSEEEECCCCCCCHHHHHHHHHHHHHHCSSTTTTCCEEEEEEECTTCHHHHHHHHGGG T ss_pred eeeCCCEEEEEeeeceecCCCCCCCCcccccccHHHHHHHHHHHHHHhcCCCcCCCceEeeEEecCCCCHHHHHHHHHHH Confidence 34567999999999987543223455433335677889999999999998877778899999999877653323333334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++.+......|...........++++++||+.++.....++.++...++|+|++.+..+.+.+...+++++++.++. T Consensus 84 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~~~ 163 (479) T 6BSZ_A 84 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 163 (479) T ss_dssp CCC-----------------------CEEEEECCSSHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTTTCTTEEESSCCH T ss_pred HHHHHhccccccccCCCCCCccCCCCceEEEEcCCCchHHHHHHHHHHHhCCCeEecCCCCccccCcccccceeecCCCh Confidence 44333210000000000000000013788999998887777888899999999999887666554434578899999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...+.++++++++++|+++++++.++.++....+.+.+.+++.+++++.....+....+..++...++++++..++++|+ T Consensus 164 ~~~~~a~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~iv 243 (479) T 6BSZ_A 164 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 243 (479) T ss_dssp HHHHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHHHSSSCEEEEEEEECSSCCTTHHHHHHHHHTTSTTCCEEE T ss_pred HHHHHHHHHHHHHhCCCEEEEEEecCcccHHHHHHHHHHHHHhCCeEEEEEEecCCCCCcchHHHHHHHHHhCCCCcEEE Confidence 98999999999889999999999877778878888887776542244443222211112234556666665224788888 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) +......+..+++++.+.++.+++.|+..+.|...............+.+.+.+.......+..++........+...++ T Consensus 244 ~~~~~~~~~~~l~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 323 (479) T 6BSZ_A 244 MFANEDDIRRILEAAKKLQQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 323 (479) T ss_dssp EECCHHHHHHHHHHHHHTTCTTTCEEEECTTTTTCSTTTTTCTTTTTTCEEEEESCCCCHHHHHHHHTCCTTTCCSCTTH T ss_pred EeCCHHHHHHHHHHHHHhccCCCeEEEEeccccCCccchhcccchheeeEEEeccccCCCcHHHHHHcCCcccCCCCHHH Confidence 87776778888999888876534667766544322110000111223333322221111122211111000011223345 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 439 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~ 439 (908) .++|++.+++..............|...+............++..+|||+++++.|+++.....+......|......++ T Consensus 324 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDav~~~~~al~~~~~~~~~~~~~~c~~~~~~~~ 403 (479) T 6BSZ_A 324 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 403 (479) T ss_dssp HHHHHHHHTCCC-----------CCCSCCCTTTTSCCCCCTTHHHHHHHHHHHHHHHHHHHHHHSSSCSSCCGGGSSCCH T ss_pred HHHHHHHhCCcccCCCCcccccccccCcccccCCccccccccHHHHHHHHHHHHHHHHHHHHhhCCCCCCCCchhccCCH Confidence 56666554432110000000011122111000000011234677899999999999998865432211122322122345 Q NP_000836.2 440 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 507 (908) Q Consensus 440 ~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~~ 507 (908) ..+.+.|++.+|.|.+|+.+.||++|++...+.+++++..+....+..||.|+....++...+.|+++ T Consensus 404 ~~l~~~l~~~~f~G~tG~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~~ 471 (479) T 6BSZ_A 404 KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHR 471 (479) T ss_dssp HHHHHHHHHCCEECTTSCEECCCTTSCCCCEEEEEEEEECSSCEEEEEEEEEESSEEECGGGCCCCCC T ss_pred HHHHHHHHhCceecCCCCceEeCCCCCCCCcEEEEEEEEeCCceeeEEEEEEecceeeeHhhceeccc Confidence 56778888889999877469999999988788888887422123578899999765555556888764 No 21 >3KS9_B Metabotropic glutamate receptor 1; Glutamate Receptors, mGluR1, Dimerization, Glutamic; HET: Z99, NAG; 1.9A {Homo sapiens} Probab=99.85 E-value=1.4e-26 Score=259.76 Aligned_cols=465 Identities=41% Similarity=0.750 Sum_probs=274.0 Template_Neff=11.100 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYA 112 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a 112 (908) ......+++++||+++|.++... ....|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+ T Consensus 9 ~~~~~~~~~~~Ig~l~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~ 88 (496) T 3KS9_B 9 RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVA 88 (496) T ss_dssp CCCEEECCSEEEEEEECSBCCCCGGGGGGTCCCCBCCCCCCHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHHH T ss_pred cceEEecCCEEEEEEEEeccCCCCCCCCCCCCccccccccHHHHHHHHHHHHHHhcCCCCCCCceEeeEEEeCCCCHHHH Confidence 34456778999999999987531 12356543334567788999999999999877777899999999988876544 Q NP_000836.2 113 LEQSLTFVQALIE----KDASDVKCANGDP--PIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 113 ~~~~~~~~~~l~~----~~~~~~~~~~~~~--~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) .+.+.+++..... +......|...+. .....+++++++||+.++.....++.++...++|+|++.+..+.+.+. T Consensus 89 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~ 168 (496) T 3KS9_B 89 LEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK 168 (496) T ss_dssp HHHHHHHHHTTC--------------------------CCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCT T ss_pred HHHHHHHHHHccccccCCCCcccccCCCCCCCCCCCCCCCeEEEEcCCCcHHHHHHHHHHHHhCCCEEEeccCchhcCCc Confidence 4443333321000 0000000000000 000001578899998887777778888999999999988766655443 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+.......++...+ T Consensus 169 ~~~~~~~~~~~~~~~~~~a~~~~l~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~l 247 (496) T 3KS9_B 169 TLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE-GLSIAHSDKIYSNAGEKSFDRLL 247 (496) T ss_dssp TTCTTEEESSCCTHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHTTT-TCEEEEEEEECTTCCHHHHHHHH T ss_pred cccCcceecCCCHHHHHHHHHHHHHHcCCCEEEEEEeCCcchhHHHHHHHHHHHHc-CCeEEEEEEecccCChhHHHHHH Confidence 34688999999999999999999988899999999987777877778888877765 35554322121111234556667 Q NP_000836.2 267 KRLLETP--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 267 ~~l~~~~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++++. . +.++|++......+..+++++++.|+..++.|++.+.|...............+.+.+.........+..+ T Consensus 248 ~~l~~-~~~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 326 (496) T 3KS9_B 248 RKLRE-RLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDY 326 (496) T ss_dssp HHHHH-TTTTCCEEEEECCHHHHHHHHHHHHHHTCCSCCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHH T ss_pred HHHHH-hCCCCeEEEEEcCHHHHHHHHHHHHHcCCCCceEEEeeccccCCchhhccccchhcceEEEEecCCCCcCHHHH Confidence 77653 3 55788777666677788888888887544567766544332110000111122333322222222223222 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGK-RNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDL 423 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~ 423 (908) +........+...++.++|++.+.+....... ...+...|.+++.... ......+++++|||++++++|++++.... T Consensus 327 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~ydav~~~a~al~~~~~~~ 404 (496) T 3KS9_B 327 FLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEE--NYVQDSKMGFVINAIYAMAHGLQNMHHAL 404 (496) T ss_dssp HTTCCTTTCCSCTTHHHHHHHHTTCBCC-------CCSSBCCSCCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHhCCCCCCCCCCcHHHHHHHHcCccCCcccCCCCCcCccCCCCccccc--cccccchHHHHHHHHHHHHHHHHHHHHHh Confidence 21111111122345666666655542110000 0001112322111100 01234567789999999999999887543 Q NP_000836.2 424 CPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVE 500 (908) Q Consensus 424 ~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~ 500 (908) +......|......++..+.+.|++..|.|.+| . ++||++|++...+.|++++..+ +...++.||.|+... .++.. T Consensus 405 ~~~~~~~c~~~~~~~~~~l~~~l~~~~f~g~tG-~~v~fd~~G~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~l~~~~~ 483 (496) T 3KS9_B 405 CPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSG-EEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDY 483 (496) T ss_dssp STTCSSCCGGGSSCCHHHHHHHHHTCEEECTTS-CEEECCTTSCCCCEEEEEEEEECSSSCEEEEEEEEEETTEEEECC- T ss_pred CCCCCCCchhcCCCCHHHHHHHHhcCceecCCC-CEEEeCCCCCCCCeEEEEEEEeCCCCceEEEEEEEEECCEEEEccc Confidence 322112232222245667888898889999988 7 9999999998888888887432 123689999999762 33334 Q NP_000836.2 501 DMQWAH 506 (908) Q Consensus 501 ~i~w~~ 506 (908) .+.|++ T Consensus 484 ~i~w~~ 489 (496) T 3KS9_B 484 KIQMNK 489 (496) T ss_dssp ------ T ss_pred eeeecC Confidence 677865 No 22 >4XAR_A Metabotropic glutamate receptor 3; mGluR2 mGluR3 ECD, SIGNALING PROTEIN; HET: 40F; 2.26A {Homo sapiens} Probab=99.85 E-value=1.6e-26 Score=260.59 Aligned_cols=462 Identities=47% Similarity=0.846 Sum_probs=277.1 Template_Neff=10.800 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ......+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+ T Consensus 32 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~A~~~iN~~~~~~~g~~l~l~~~d~~~~~~~a~~~~ 111 (517) T 4XAR_A 32 RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQS 111 (517) T ss_dssp CCCEEECCSEEEEEEECCEEECSTTCSEEEECCCCCCHHHHHHHHHHHHHTTCSSSSTTCCEEEEEEECTTCHHHHHHHH T ss_pred hcceeecCCEEEEEEeeceecCCCCCCCccccccccHHHHHHHHHHHHHHhcCCCCCCCCeEeEEEEeCCCCHHHHHHHH Confidence 34456688999999999987543233454332235677889999999999998888888999999999887755444333 Q NP_000836.2 117 LTFVQALIEK-DASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 117 ~~~~~~l~~~-~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) .+++.+.... +.....|........ ....++++++|+.++.....++.++...++|+|++.+..+.+.+...++++++ T Consensus 112 ~~l~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~ 191 (517) T 4XAR_A 112 LEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 191 (517) T ss_dssp GGGTGGGC----------------------CCCSEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEE T ss_pred HHHHHhcccccchhhhcCCCCChhhhcCCCcceEEEEcCCCcHHHHHHHHHHHHhCCCeeecccCCcccCCccccCceee Confidence 3333210000 000000000000000 00025788999888877778888899999999998876665554445789999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.|+....+.++++++.+++|++++++++++.++....+.+++.+++. ++++.....++......++...+++++...+ T Consensus 192 ~~p~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~l~~i~~~~~ 270 (517) T 4XAR_A 192 TVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NISIATAEKVGRSNIRKSYDSVIRELLQKPN 270 (517) T ss_dssp SSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSTTCCCHHHHHHHHHTCTT T ss_pred eCCCcHHHHHHHHHHHHHcCCcEEEEEEecCcchHHHHHHHHHHHHHC-CCEEEEEEecCcccccccHHHHHHHHHcCCC Confidence 999999999999999988999999999987778888888888887765 3555433222211122345556666631247 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) +|+|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.........+..++....+.... T Consensus 271 ~~~vvl~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 348 (517) T 4XAR_A 271 ARVVVLFMRSDDSRELIAAASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNH 348 (517) T ss_dssp CCEEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCTTTSTTCEEEEECCCCCHHHHHHHHTCCTTTCC T ss_pred ceEEEEECChHHHHHHHHHHHHcCC--CEEEEEecchhccchhhcCCcceecceEEEEEcccCCccHHHHHHhCCCCCCC Confidence 8888887777778889998888876 35677665544321110001122333333322222222333332221111122 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ...++.++|++.+.+..... ......|...+.... .......++.++|||++++++|++++....+......|... T Consensus 349 ~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~~~~~~~-~~~~~~~~~~~~ydav~~~a~al~~~~~~~~~~~~~~c~~~ 424 (517) T 4XAR_A 349 RNPWFRDFWEQKFQCSLQNK---RNHRRVCDKHLAIDS-SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAM 424 (517) T ss_dssp SCTTHHHHHHHHTTSBC----------CBCCTTCCCCT-TTCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGG T ss_pred CChHHHHHHHHHcCCccCCc---ccCCcccccccccCC-CccccccchhHHHHHHHHHHHHHHHHHHhhCCCCCCcchhh Confidence 33456666666554421100 000011211110000 00123456788999999999999998764432211223211 Q NP_000836.2 435 ST-IDGKELLGYIRAVNFNG-------SAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 435 ~~-~~~~~l~~~l~~~~f~G-------~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .. ..+..+.+.+++..|.| .+| ++.||.+|++...+.|++++..++...++.||.|+....++...+.|++ T Consensus 425 ~~~~~~~~l~~~l~~~~f~g~~~~~~~~tG-~v~fd~~G~r~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 503 (517) T 4XAR_A 425 KILDGKKLYKDYLLKINFTAPFNPNKDADS-IVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR 503 (517) T ss_dssp SSCCHHHCCCCCCSCEEECCC-----CCCC-EEECCTTSCCCCEEEEEEEEESSSCEEEEEEEEEESSEEECGGGCCCSC T ss_pred cccchHHHHHHHHhcCcccCCCCCCCCCCc-eeEeCCCCCCCCcEEEEEEEEeCCEEEEEEEEEEeeeEEeccccEEecC Confidence 11 12234667788888998 778 8999999999888999998743212368899999976444444677864 No 23 >6B7H_A Metabotropic glutamate receptor 3; mGluR3 Glutamate, MEMBRANE PROTEIN-AGONIST complex; HET: NAG, CWY; 2.82A {Homo sapiens} Probab=99.85 E-value=1.6e-26 Score=260.59 Aligned_cols=462 Identities=47% Similarity=0.846 Sum_probs=275.1 Template_Neff=10.800 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ......+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+ T Consensus 32 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~~~~~A~~~iN~~~~~~~g~~l~l~~~d~~~~~~~a~~~~ 111 (517) T 6B7H_A 32 RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQS 111 (517) T ss_dssp CCCEEC-CCEEEEEEECCEEC----CCCCEECCCCCCCHHHHHHHHHHHHTTCSSSSTTCCEEEEEEECTTCHHHHHHHH T ss_pred hcceeecCCEEEEEEeeceecCCCCCCCccccccccHHHHHHHHHHHHHHhcCCCCCCCCeEeEEEEeCCCCHHHHHHHH Confidence 34456688999999999987543233454332235677889999999999998888888999999999887755444333 Q NP_000836.2 117 LTFVQALIEK-DASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 117 ~~~~~~l~~~-~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) .+++.+.... +.....|........ ....++++++|+.++.....++.++...++|+|++.+..+.+.+...++++++ T Consensus 112 ~~l~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~ 191 (517) T 6B7H_A 112 LEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 191 (517) T ss_dssp GGGTSTTC---------------------CCCEEEEECCSSHHHHHHHHHHHHTTTCCEEESSCCCGGGGCTTTCTTEEE T ss_pred HHHHHhcccccchhhhcCCCCChhhhcCCCcceEEEEcCCCcHHHHHHHHHHHHhCCCeeecccCCcccCCccccCceee Confidence 3333210000 000000000000000 00025788999888877778888899999999998876665554445789999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.|+....+.++++++.+++|++++++++++.++....+.+++.+++. ++++.....++......++...+++++...+ T Consensus 192 ~~p~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~l~~i~~~~~ 270 (517) T 6B7H_A 192 TVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NISIATAEKVGRSNIRKSYDSVIRELLQKPN 270 (517) T ss_dssp SSCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEESSSTTSCCHHHHHHHHHTCTT T ss_pred eCCCcHHHHHHHHHHHHHcCCcEEEEEEecCcchHHHHHHHHHHHHHC-CCEEEEEEecCcccccccHHHHHHHHHcCCC Confidence 999999999999999988999999999987778888888888887765 3555433222211122345556666631247 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) +|+|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.........+..++....+.... T Consensus 271 ~~~vvl~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 348 (517) T 6B7H_A 271 ARVVVLFMRSDDSRELIAAASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNH 348 (517) T ss_dssp CCEEEEECCHHHHHHHHHHHHTTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHHHCCTTTCC T ss_pred ceEEEEECChHHHHHHHHHHHHcCC--CEEEEEecchhccchhhcCCcceecceEEEEEcccCCccHHHHHHhCCCCCCC Confidence 8888887777778889998888876 35677665544321110001122333333322222222333332221111122 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ...++.++|++.+.+..... ......|...+.... .......++.++|||++++++|++++....+......|... T Consensus 349 ~~~~~~~~~~~~~~~~~~~~---~~~~~~~~~~~~~~~-~~~~~~~~~~~~ydav~~~a~al~~~~~~~~~~~~~~c~~~ 424 (517) T 6B7H_A 349 RNPWFRDFWEQKFQCSLQNK---RNHRRVCDKHLAIDS-SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAM 424 (517) T ss_dssp SCTTHHHHHHHHTTCBC----------CBCCTTCCCCT-TTCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGG T ss_pred CChHHHHHHHHHcCCccCCc---ccCCcccccccccCC-CccccccchhHHHHHHHHHHHHHHHHHHhhCCCCCCcchhh Confidence 33456666666554421100 000011211110000 00123456788999999999999998764432211223211 Q NP_000836.2 435 ST-IDGKELLGYIRAVNFNG-------SAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 435 ~~-~~~~~l~~~l~~~~f~G-------~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .. ..+..+.+.+++..|.| .+| ++.||.+|++...+.|++++..++...++.||.|+....++...+.|++ T Consensus 425 ~~~~~~~~l~~~l~~~~f~g~~~~~~~~tG-~v~fd~~G~r~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 503 (517) T 6B7H_A 425 KILDGKKLYKDYLLKINFTAPFNPNKDADS-IVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR 503 (517) T ss_dssp SSCCHHHCCCCCCSCEEECCC-----CCTT-EEECCTTSCCCCCEEEEEEEESSSSEEEEEEEEESSSEEECGGGCCCSC T ss_pred cccchHHHHHHHHhcCcccCCCCCCCCCCc-eeEeCCCCCCCCcEEEEEEEEeCCEEEEEEEEEEeeeEEeccccEEecC Confidence 11 12234667788888998 778 8999999999888999998743212368899999976444444677864 No 24 >1EWK_B METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1; SIGNAL TRANSDUCTION, NEUROTRANSMITTER, CNS, NEURON; HET: EPE, NAG, GLU; 2.2A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.85 E-value=1.8e-26 Score=258.44 Aligned_cols=464 Identities=42% Similarity=0.763 Sum_probs=275.1 Template_Neff=11.000 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYAL 113 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~ 113 (908) .....+++++||+++|+++... ....|+......+.+...|+++|++++|+++++++++++++.+.|+++++..+. T Consensus 5 ~~~~~~~~~~ig~l~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~ 84 (490) T 1EWK_B 5 SVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVAL 84 (490) T ss_dssp CCEEECCSEEEEEEECSBCCCCGGGTTTTCCCSBCCCCCCHHHHHHHHHHHHHHTCSSSSTTCCEEEEEEECTTSHHHHH T ss_pred ceeEecCCEEEEEEEEeccCCCCCCCCCCCcccccccccHHHHHHHHHHHHHHhcCCCCCCCceEeeEEEecCCCHHHHH Confidence 3456778999999999987532 134676544445677889999999999998877788999999999988765444 Q NP_000836.2 114 EQSLTFVQALIE----KDASDVKCANGDP--PIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNT 187 (908) Q Consensus 114 ~~~~~~~~~l~~----~~~~~~~~~~~~~--~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~ 187 (908) +.+.+++..... +......|...+. ......+++++++|+.++.....++.++...++|+|++.+..+.+.+.. T Consensus 85 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~ 164 (490) T 1EWK_B 85 EQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKT 164 (490) T ss_dssp HHHHHHHC-----------------------------CCEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTT T ss_pred HHHHHHHHHccccccCCcccccccCCCCCCCCCCCCCCCeEEEEcCCCchHHHHHHHHhhhhCCCEEEeccCchhhcCcc Confidence 443333321000 0000000000000 0000015788999988877777778888999999999877665554433 Q NP_000836.2 188 RYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 188 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .+++++++.++....+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++ T Consensus 165 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~vl~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~~~~~~~~~~~~~ 243 (490) T 1EWK_B 165 LYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE-GLCIAHSDKIYSNAGEKSFDRLLR 243 (490) T ss_dssp TCTTEEESSCCTHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHH T ss_pred cccceeecCCChHHHHHHHHHHHHHcCCCEEEEEEeCCccchhhHHHHHHHHHHc-CceEEEeeEeccccchHHHHHHHH Confidence 4689999999988889999999988899999999987778887888888877765 355543321211112335566677 Q NP_000836.2 268 RLLETP--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 268 ~l~~~~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++. . +.++|++......+..+++++++.|+.+++.|++.+.|...............+.+.+.........+..++ T Consensus 244 ~l~~-~~~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 322 (490) T 1EWK_B 244 KLRE-RLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYF 322 (490) T ss_dssp HHHH-TTTTCCEEEEECCHHHHHHHHHHHHHHTCCSCCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHH T ss_pred HHHH-hCCCCeEEEEEcChHHHHHHHHHHHHcCCCCeeEEEecccccCchhhhhccccccceeEEEEecCCCCCCHHHHH Confidence 7753 3 457787776666778899999888875445677665443321100001111223222221111112222222 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGK-RNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ........+...++.++|++.+.+....... .......|++++.... ......+++.+|||++++++|++++....+ T Consensus 323 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDav~~~a~al~~~~~~~~ 400 (490) T 1EWK_B 323 LKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEE--NYVQDSKMGFVINAIYAMAHGLQNMHHALC 400 (490) T ss_dssp TTCCTTTCCSCTTHHHHHHHHTTCBCTTCTTCCTTCCSBCCSCCCTTT--TCCCCTTHHHHHHHHHHHHHHHHHHHHHHS T ss_pred HhCCCCCCCCCCcHHHHHHHHcCccCCcccCCCCccCccCCCCccccc--ccccccchHHHHHHHHHHHHHHHHHHHHhC Confidence 1111111123345666666665542210000 0000112322111100 011345677899999999999998865433 Q NP_000836.2 425 PGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVED 501 (908) Q Consensus 425 ~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~ 501 (908) ......|......++..+.+.|++..|.|.+| . +.||++|++...+.|.+++..+ +...++.||.|+... .++... T Consensus 401 ~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~ 479 (490) T 1EWK_B 401 PGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSG-EEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYK 479 (490) T ss_dssp TTCSSCCGGGSSCCHHHHHHHHHTCCEECTTS-CEECCCTTSCCCCEEEEEEEEECSSSCEEEEEEEEEETTEEEECTTT T ss_pred CCCCCCchhcCCCCHHHHHHHHhcCceecCCC-CeEEECCCCCCCCeEEEEEEEEccCCeeEEEEEEEEECCEEEEccce Confidence 21112232222235667888898889999998 7 9999999988888888887432 223689999999762 233346 Q NP_000836.2 502 MQWAH 506 (908) Q Consensus 502 i~w~~ 506 (908) +.|++ T Consensus 480 ~~w~~ 484 (490) T 1EWK_B 480 IQMNK 484 (490) T ss_dssp C---- T ss_pred eeecC Confidence 78865 No 25 >1EWT_A METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1; SIGNAL TRANSDUCTION, NEUROTRANSMITTER, CNS, NEURON; HET: SO4, NAG; 3.7A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.85 E-value=1.8e-26 Score=258.44 Aligned_cols=464 Identities=42% Similarity=0.763 Sum_probs=275.4 Template_Neff=11.000 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGE----RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYAL 113 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~----~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~ 113 (908) .....+++++||+++|+++... ....|+......+.+...|+++|++++|+++++++++++++.+.|+++++..+. T Consensus 5 ~~~~~~~~~~ig~l~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~ 84 (490) T 1EWT_A 5 SVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVAL 84 (490) T ss_dssp CEEEECCSEEEEEEECCBCCCCGGGTTTTCCCSBCCCCCCCHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHHHH T ss_pred ceeEecCCEEEEEEEEeccCCCCCCCCCCCcccccccccHHHHHHHHHHHHHHhcCCCCCCCceEeeEEEecCCCHHHHH Confidence 3456778999999999987532 134676544445677889999999999998877788999999999988765444 Q NP_000836.2 114 EQSLTFVQALIE----KDASDVKCANGDP--PIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNT 187 (908) Q Consensus 114 ~~~~~~~~~l~~----~~~~~~~~~~~~~--~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~ 187 (908) +.+.+++..... +......|...+. ......+++++++|+.++.....++.++...++|+|++.+..+.+.+.. T Consensus 85 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~ 164 (490) T 1EWT_A 85 EQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKT 164 (490) T ss_dssp HHHHHHHHHHHHTTC----------------------CCEEEEECCSCHHHHHHHHHHHTTTTCCEEESSCCCGGGGCTT T ss_pred HHHHHHHHHccccccCCcccccccCCCCCCCCCCCCCCCeEEEEcCCCchHHHHHHHHhhhhCCCEEEeccCchhhcCcc Confidence 443333321000 0000000000000 0000015788999988877777778888999999999877665554433 Q NP_000836.2 188 RYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 188 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .+++++++.++....+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++ T Consensus 165 ~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~vl~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~~~~~~~~~~~~~ 243 (490) T 1EWT_A 165 LYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE-GLCIAHSDKIYSNAGEKSFDRLLR 243 (490) T ss_dssp TCTTEEESSBCSHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-CCEEEEEEEECTTCCHHHHHHHHH T ss_pred cccceeecCCChHHHHHHHHHHHHHcCCCEEEEEEeCCccchhhHHHHHHHHHHc-CceEEEeeEeccccchHHHHHHHH Confidence 4689999999988889999999988899999999987778887888888877765 355543321211112335566677 Q NP_000836.2 268 RLLETP--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 268 ~l~~~~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++. . +.++|++......+..+++++++.|+.+++.|++.+.|...............+.+.+.........+..++ T Consensus 244 ~l~~-~~~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 322 (490) T 1EWT_A 244 KLRE-RLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYF 322 (490) T ss_dssp HHHH-TTTTTTEEEEECCHHHHHHHHHHHHHTTCCSSCEEEECTTTTTCTTTSSSTTTTTTTCEEEEECCCCCHHHHHHH T ss_pred HHHH-hCCCCeEEEEEcChHHHHHHHHHHHHcCCCCeeEEEecccccCchhhhhccccccceeEEEEecCCCCCCHHHHH Confidence 7753 3 457787776666778899999888875445677665443321100001111223222221111112222222 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGK-RNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ........+...++.++|++.+.+....... .......|++++.... ......+++.+|||++++++|++++....+ T Consensus 323 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~--~~~~~~~~~~~yDav~~~a~al~~~~~~~~ 400 (490) T 1EWT_A 323 LKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEE--NYVQDSKMGFVINAIYAMAHGLQNMHHALC 400 (490) T ss_dssp HSCCTTTCCSCTTHHHHHHHHHTCBCSSCSSCCTTCSSBCCSCCCTTT--TCCCCSTHHHHHHHHHHHHHHHHHHHHHHS T ss_pred HhCCCCCCCCCCcHHHHHHHHcCccCCcccCCCCccCccCCCCccccc--ccccccchHHHHHHHHHHHHHHHHHHHHhC Confidence 1111111123345666666665542210000 0000112322111100 011345677899999999999998865433 Q NP_000836.2 425 PGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTP-VTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQL-HLKVED 501 (908) Q Consensus 425 ~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~-v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~-~~~~~~ 501 (908) ......|......++..+.+.|++..|.|.+| . +.||++|++...+.|.+++..+ +...++.||.|+... .++... T Consensus 401 ~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG-~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~ 479 (490) T 1EWT_A 401 PGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSG-EEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYK 479 (490) T ss_dssp SSCSSCCGGGSSCCHHHHHHHHHTCEEECTTS-CEEECCTTSCBCCEEEEEEEEECSSSCEEEEEEEEEETTEEEECGGG T ss_pred CCCCCCchhcCCCCHHHHHHHHhcCceecCCC-CeEEECCCCCCCCeEEEEEEEEccCCeeEEEEEEEEECCEEEEccce Confidence 21112232222235667888898889999998 7 9999999988888888887432 223689999999762 233346 Q NP_000836.2 502 MQWAH 506 (908) Q Consensus 502 i~w~~ 506 (908) +.|++ T Consensus 480 ~~w~~ 484 (490) T 1EWT_A 480 IQMNK 484 (490) T ss_dssp C---- T ss_pred eeecC Confidence 78865 No 26 >5C5C_A Metabotropic glutamate receptor 7; GLUTAMATE RECEPTORS, GLUTAMIC ACID BINDING; HET: NAG, UNX; 1.862A {Homo sapiens} Probab=99.85 E-value=2e-26 Score=257.70 Aligned_cols=468 Identities=73% Similarity=1.247 Sum_probs=271.6 Template_Neff=11.400 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++++.|++++.....+.+. T Consensus 9 ~~~~~~~~i~ig~~~p~~~~~~~~~~~~~~~~~~g~~~~~~~~~A~~~in~~~~~~~g~~i~~~~~d~~~~~~~~~~~~~ 88 (481) T 5C5C_A 9 HSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL 88 (481) T ss_dssp CEEEECCSEEEEEEECCEEECSSSCSEEEECCCCCCCHHHHHHHHHHHHHTCTTSSTTCCEEEEEEECTTCHHHHHHHHG T ss_pred ceeEeCCCEEEEEEeeeeecCCCCCCCCcccccccHHHHHHHHHHHHHHcCCCCCCCCceeeeEEEcCCCCHHHHHHHHH Confidence 34566789999999999875332234543333356778899999999999988887789999999988765333233333 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.+++++........|...........++++++||+.++.....++.++...++|+|++.+..+.+.+...+++++++.+ T Consensus 89 ~~~~~l~~~~~~~~~c~~~~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 168 (481) T 5C5C_A 89 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVP 168 (481) T ss_dssp GGGTTTC------------------CCCCEEEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTCTTEEESSC T ss_pred HHHHHHHccCCCCcccCCCCCCCccccccEEEEEcCCCcHHHHHHHHHHHHhCCCEEecCCCCcccCCCcccccccccCC Confidence 33333321000000000000000001257889999988877777888899999999998876655544335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~ 275 (908) +...+++++++++++++|+++++++.++.++....+.+++.+++.+++++.....+... ....++...+++++...++ T Consensus 169 ~~~~~~~~l~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~g~~v~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~ 248 (481) T 5C5C_A 169 PDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLSIAQSVRIPQERKDRTIDFDRIIKQLLDTPNS 248 (481) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHHSSCEEEEEEEECCCCTTCCCCHHHHHHHHHTSSSC T ss_pred CCHHHHHHHHHHHHHhCCCEEEEEEeCCchhHHHHHHHHHHHHHcCCceEEEEEEcCCccCCchhcHHHHHHHHHcCCCc Confidence 99889999999998899999999998777888888888877765423444433222210 0123455566666521368 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) |+|++......+..+++++++.++..++.|++.+.|...............+.+.+.+.......|..++....+..... T Consensus 249 ~~vv~~~~~~~~~~~l~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 328 (481) T 5C5C_A 249 RAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 328 (481) T ss_dssp CEEEEEECHHHHHHHHHHHHHSSSCCCEEEEESSCC---------CCCCCTTCEEEEECCCCCHHHHHHHHTCCTTTCTT T ss_pred eEEEEEcCHHHHHHHHHHHHHhccCCCEEEEEeccccCCCcccccccceecceEEEEeccccCccHHHHHhcCCCccCCC Confidence 88888777777888999998887653456776654432210000011122333332221111122222211100011123 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKR-NSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~-~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ..+|.++|++.+++........ ..+...|................+++++|||+++++.++++.....+....+.|... T Consensus 329 ~~~f~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~ 408 (481) T 5C5C_A 329 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEM 408 (481) T ss_dssp STTHHHHHHHHTTCBC----------CCBCCSCCCTTTTSCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCHHH T ss_pred ChHHHHHHHHHcCCcCcCCCCCcccCCCCCCCCccccCcccccccccHHHHHHHHHHHHHHHHHHHHhhcCCCCCCChHH Confidence 3455666665554321100000 000111211100000000122346788999999999999998754332111223221 Q NP_000836.2 435 STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.+.|++.+|.|.+|..++||++|++...+.+++++..+ +...++.||.|+....+....+.|. T Consensus 409 ~~~~~~~l~~~l~~~~f~G~tG~~v~fd~~g~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~ 480 (481) T 5C5C_A 409 EQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWG 480 (481) T ss_dssp HHHHHHHHHHHHHTCCEECTTSSEECCCTTSBCCCCEEEEEEECCC---CEEEEEEEESSSEEECGGGSCC- T ss_pred HhhcHHHHHHHHhcCceecCCCCeEEeCCCCCCCCeEEEEEEEecCCCCCceEEeEEEccceeEehhhceec Confidence 1224456778888889999887459999999988788888887432 1245789999997654544467773 No 27 >3SM9_A Metabotropic glutamate receptor 3; Structural Genomics, Structural Genomics Consortium; HET: SO4, Z99; 2.26A {Homo sapiens} Probab=99.84 E-value=2.4e-26 Score=256.80 Aligned_cols=459 Identities=47% Similarity=0.859 Sum_probs=274.8 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||+++|.++.......|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.++ T Consensus 8 ~~~~~~i~ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~a~~~iN~~~~~~~g~~l~l~~~D~~~~~~~~~~~~~~l 87 (479) T 3SM9_A 8 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEF 87 (479) T ss_dssp EEECCSEEEEEEECCEEECC-CCSEEEECCCCCCCHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred eEecCCEEEEeeeeceecCCCCCCCCcccccccHHHHHHHHHHHHHHhcCCCCCCCCeEEEEEeeCCCCHHHHHHHHHHH Confidence 45678999999999987543234565433345677889999999999998888788999999999887655444333333 Q NP_000836.2 120 VQALIEK-DASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 120 ~~~l~~~-~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.+.... +.....|........ ....++++++|+.++.....++.++...++|+|++....+.+.+...+++++++.+ T Consensus 88 ~~~~~~~~~~~~~~c~~~~~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~ 167 (479) T 3SM9_A 88 VRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVP 167 (479) T ss_dssp HHTCC-----------------------CEEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTTTTEEESSC T ss_pred HHhcccCccchhhcCCCCChhhhcCCCcceEEEEcCCChHHHHHHHHHHHHhCCCEEecCccChhhcCcccCCceeeeCC Confidence 3210000 000000000000000 00025789999988877778888889999999998776655544335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) +....+.++++++.+++|+++++++.++.++....+.+++.+++. ++++.....++......++...++++....++|+ T Consensus 168 ~~~~~~~a~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~ 246 (479) T 3SM9_A 168 PDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLR-NISIATAEKVGRSNIRKSYDSVIRELLQKPNARV 246 (479) T ss_dssp CTHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHTT-TCEEEEEEEECC--CHHHHHHHHHHHHTCTTCCE T ss_pred ChHHHHHHHHHHHHHcCCcEEEEEEecCchhHHHHHHHHHHHHHC-CcEEEEEEEeCcccccccHHHHHHHHHhCCCccE Confidence 998899999999988999999999987778888888888887775 4555443323211112345556666621247888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) |++......+..+++++++.|+ ++.|++.+.|...............|.+.+.........|..++....+...+.++ T Consensus 247 vvl~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 324 (479) T 3SM9_A 247 VVLFMRSDDSRELIAAASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNP 324 (479) T ss_dssp EEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCTTTTTTCEEEEECCCCCHHHHHHHHTCCTTTCTTCT T ss_pred EEEEcChHHHHHHHHHHHHcCC--CEEEEEeCcccccchhHcCCcceeceeEEEEEccccChhHHHHHHhCCCCCCCCCH Confidence 8887777778889999888876 35677665444321110001122334333332222222333333222111223345 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) ++.++|++.+.+..... ......|...+..... ....+.++.++|||++++++|++++....+......|...... T Consensus 325 ~~~~~~~~~~~~~~~~~---~~~~~~c~~~~~~~~~-~~~~~~~~~~~ydav~~~a~al~~~~~~~~~~~~~~c~~~~~~ 400 (479) T 3SM9_A 325 WFRDFWEQKFQCSLQNK---RNHRRVCDKHLAIDSS-NYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKIL 400 (479) T ss_dssp THHHHHHHHHTCBCCC------CSCBCCTTCCCCTT-TCCCCTTHHHHHHHHHHHHHHHHHHHHHHSTTCSSCCHHHHSC T ss_pred HHHHHHHHHcCCccCCc---cCCCCccCccccccCc-cccccccchHHHHHHHHHHHHHHHHHHhhCCCCCCCchhhccc Confidence 66777776665432110 0001122211111000 0113456778999999999999998764332211223211111 Q NP_000836.2 438 D-GKELLGYIRAVNFNG-------SAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 438 ~-~~~l~~~l~~~~f~G-------~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) + +..+.+.|++..|.| .+| .|.|+++|++...+.+++++..++...++.||.|+....++...+.|++ T Consensus 401 ~~~~~l~~~l~~~~f~g~~~~~~~~~G-~v~f~~~g~r~~~~~i~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 476 (479) T 3SM9_A 401 DGKKLYKDYLLKINFTAPFNPNKDADS-IVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR 476 (479) T ss_dssp CHHHCCCCCGGGCCEECTTC-----CC-EECCCTTCBCCCCEEEEEEEESSSCEEEEEEEEESSSEEECGGGCCCC- T ss_pred ChHHHHHHHHhcCcccCCCCCCCCCCC-eeEeCCCCCCCCcEEEEEEEEeCCeEEEEEEEEEeeeeEecccceeecc Confidence 1 224667788888988 777 8999999999888899988743212358899999876444434577754 No 28 >4XAQ_A Metabotropic glutamate receptor 2; mGluR2 mGluR3, SIGNALING PROTEIN; HET: 40F, SO4; 2.21A {Homo sapiens} Probab=99.83 E-value=9.3e-26 Score=253.40 Aligned_cols=453 Identities=45% Similarity=0.841 Sum_probs=270.3 Template_Neff=10.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.++ T Consensus 28 ~~~~~~i~Ig~~~p~~~~~g~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~~~l 107 (503) T 4XAQ_A 28 LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDF 107 (503) T ss_dssp EEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHHHCTTSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred EEeCCCEEEEEEeeceeCCCCcccCCcccccccHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEEeCCCCHHHHHHHHHHH Confidence 46778999999999972211122354332235667889999999999998777778999999999887655443333333 Q NP_000836.2 120 VQALIEK--DASDVKCANGDPPIFT-KPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 120 ~~~l~~~--~~~~~~~~~~~~~~~~-~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +...... ......|...++.|.. ..+++++++|+.++.....++.+++..++|+|++.+..+.+.++..+++++++. T Consensus 108 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 187 (503) T 4XAQ_A 108 VRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 187 (503) T ss_dssp HTTTC-----------------------CCCCEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESS T ss_pred HHHHhccCCCCCceeCCCCccccCCCCCCceEEEEcCCCcHHHHHHHHHHHHhCCCEEecCCCCccccCccccCceeeeC Confidence 3210000 0000000000000000 013688999988887777888889999999999877666555444578899999 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR 276 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 276 (908) ++....+.++++++++++|+++++++.+++++....+.+++.+++. ++++.....++......++...++++....+++ T Consensus 188 ~~~~~~~~~l~~~l~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~ 266 (503) T 4XAQ_A 188 PPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NISVATSEKVGRAMSRAAFEGVVRALLQKPSAR 266 (503) T ss_dssp CCHHHHHHHHHHHHHHHTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHHHHTCTTCC T ss_pred CChHHHHHHHHHHHHHcCCcEEEEEEeCCcchhHHHHHHHHHHHHC-CcEEEeEEecccccCHHHHHHHHHHHHcCCCce Confidence 9998889999999988999999999987778888888888877765 355543332321012234556666664224788 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.......+.|..++....+...+.. T Consensus 267 ~iv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 344 (503) T 4XAQ_A 267 VAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRN 344 (503) T ss_dssp EEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEESCCCCTTHHHHHHTCCTTTCCSC T ss_pred EEEEEcChHHHHHHHHHHHHhCC--CEEEEEeCCcccchHHHhcCcccccceEEEEeccccCccHHHHHHcCCcCCCCCC Confidence 88887777778888988888877 3567766544332110000112233444333222222233322221111111233 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) .++.++|++.+.+.... ..|..... .. ....+..++..+|||+++++.|+++.....+......|..... T Consensus 345 ~~~~~~~~~~~~~~~~~--------~~~~~~~~-~~-~~~~~~~~a~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~~~ 414 (503) T 4XAQ_A 345 PWFREFWEQRFRCSFRQ--------RDCAAHSL-RA-VPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRP 414 (503) T ss_dssp TTHHHHHHHHTTCCSSS--------CCCSSCCT-TT-SCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCGGGSS T ss_pred HHHHHHHHHHhCCccCC--------CCCCCccc-cc-CCcccccchhHHHHHHHHHHHHHHHHHHHHCCCCCCCchhcCC Confidence 45666666655542110 01211100 00 0012334577899999999999999875433221122322112 Q NP_000836.2 437 IDGKE-LLGYIRAVNFN------GSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 437 ~~~~~-l~~~l~~~~f~------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .++.. +.+.|++..|. |.+| .++||++|++...+.+++++..+ +...++.||.|++...++...+.|++ T Consensus 415 ~~~~~~~~~~l~~~~f~~~~~~~G~~G-~v~fd~~g~~~~~~~v~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 491 (503) T 4XAQ_A 415 VNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 491 (503) T ss_dssp CCHHHCCCCCGGGCCEECTTCCSSCCC-EECCCTTSCCCCCEEEEEEEECTTSCEEEEEEEEESSSEEECGGGSCC-- T ss_pred cCHHHHHHHHHHhCeecCCCCCCCCCC-cEEeCCCCCCCCeEEEEEEEEcCCCceEEEEEEEEcCCcEEccceeeecC Confidence 23334 33567777787 7888 89999999998888888887431 12258899999976544444678865 No 29 >5CNI_A Metabotropic glutamate receptor 2; receptor, glutamate, metabotropic, SIGNALING PROTEIN; HET: GGL, NAG; 2.69A {Homo sapiens} Probab=99.83 E-value=9.3e-26 Score=253.40 Aligned_cols=453 Identities=45% Similarity=0.841 Sum_probs=270.0 Template_Neff=10.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.++ T Consensus 28 ~~~~~~i~Ig~~~p~~~~~g~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~~~l 107 (503) T 5CNI_A 28 LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDF 107 (503) T ss_dssp EEECCSEEEEEEECCEEECCSSCSEEEECCCCCCCHHHHHHHHHHHHTTCTTSSTTCCEEEEEEECTTCHHHHHHHHHHH T ss_pred EEeCCCEEEEEEeeceeCCCCcccCCcccccccHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEEeCCCCHHHHHHHHHHH Confidence 46778999999999972211122354332235667889999999999998777778999999999887655443333333 Q NP_000836.2 120 VQALIEK--DASDVKCANGDPPIFT-KPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 120 ~~~l~~~--~~~~~~~~~~~~~~~~-~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +...... ......|...++.|.. ..+++++++|+.++.....++.+++..++|+|++.+..+.+.++..+++++++. T Consensus 108 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 187 (503) T 5CNI_A 108 VRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 187 (503) T ss_dssp HSCC------------------------CCCCEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTCTTEEESS T ss_pred HHHHhccCCCCCceeCCCCccccCCCCCCceEEEEcCCCcHHHHHHHHHHHHhCCCEEecCCCCccccCccccCceeeeC Confidence 3210000 0000000000000000 013688999988887777888889999999999877666555444578899999 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR 276 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 276 (908) ++....+.++++++++++|+++++++.+++++....+.+++.+++. ++++.....++......++...++++....+++ T Consensus 188 ~~~~~~~~~l~~~l~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~i~~~~~~~ 266 (503) T 5CNI_A 188 PPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NISVATSEKVGRAMSRAAFEGVVRALLQKPSAR 266 (503) T ss_dssp CCTHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHTT-TCEEEEEEEECSSCCHHHHHHHHHHHHTCTTCC T ss_pred CChHHHHHHHHHHHHHcCCcEEEEEEeCCcchhHHHHHHHHHHHHC-CcEEEeEEecccccCHHHHHHHHHHHHcCCCce Confidence 9998889999999988999999999987778888888888877765 355543332321012234556666664224788 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +|++......+..+++++++.|+ ++.|++.+.|...............+.+.+.......+.|..++....+...+.. T Consensus 267 ~iv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 344 (503) T 5CNI_A 267 VAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRN 344 (503) T ss_dssp EEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHHTCCTTTCCSC T ss_pred EEEEEcChHHHHHHHHHHHHhCC--CEEEEEeCCcccchHHHhcCcccccceEEEEeccccCccHHHHHHcCCcCCCCCC Confidence 88887777778888988888877 3567766544332110000112233444333222222233322221111111233 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) .++.++|++.+.+.... ..|..... .. ....+..++..+|||+++++.|+++.....+......|..... T Consensus 345 ~~~~~~~~~~~~~~~~~--------~~~~~~~~-~~-~~~~~~~~a~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~~~ 414 (503) T 5CNI_A 345 PWFREFWEQRFRCSFRQ--------RDCAAHSL-RA-VPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRP 414 (503) T ss_dssp TTHHHHHHHHHTCCCC---------CCSTTCCT-TT-SCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCTTCSSCCGGGSS T ss_pred HHHHHHHHHHhCCccCC--------CCCCCccc-cc-CCcccccchhHHHHHHHHHHHHHHHHHHHHCCCCCCCchhcCC Confidence 45666666655542110 01211100 00 0012334577899999999999999875433221122322112 Q NP_000836.2 437 IDGKE-LLGYIRAVNFN------GSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 437 ~~~~~-l~~~l~~~~f~------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) .++.. +.+.|++..|. |.+| .++||++|++...+.+++++..+ +...++.||.|++...++...+.|++ T Consensus 415 ~~~~~~~~~~l~~~~f~~~~~~~G~~G-~v~fd~~g~~~~~~~v~~~~~~~~~~~~~~~vg~~~~~~~~~~~~~~w~~ 491 (503) T 5CNI_A 415 VNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 491 (503) T ss_dssp CCHHHCCCCCGGGCCEECTTCCTTCCC-EECCCTTSCCCCEEEEEEEEECC--CEEEEEEEEEESSEEECTTSSCC-- T ss_pred cCHHHHHHHHHHhCeecCCCCCCCCCC-cEEeCCCCCCCCeEEEEEEEEcCCCceEEEEEEEEcCCcEEccceeeecC Confidence 23334 33567777787 7888 89999999998888888887431 12258899999976544444678865 No 30 >5CNJ_A Metabotropic glutamate receptor 2; glutamate receptor analog, SIGNALING PROTEIN; HET: 52Q, NAG; 2.65A {Homo sapiens} Probab=99.83 E-value=1.1e-25 Score=252.80 Aligned_cols=454 Identities=45% Similarity=0.841 Sum_probs=271.0 Template_Neff=10.800 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.+........|+......+.....|+++|++++|+++++++|+++++.+.|+++++..+.+.+.+ T Consensus 27 ~~~~~~~i~Ig~~~p~~~~~g~~~~c~~~~~~~~~~~~~~~~~a~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~~~ 106 (503) T 5CNJ_A 27 VLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALD 106 (503) T ss_dssp CEEECCSEEEEEEECCEEECCTTCSEEEECCCCCCCHHHHHHHHHHHHTTCSSSSSSCCEEEEEEECTTCHHHHHHHGGG T ss_pred eEEeCCCEEEEEeeecccCCCCCCCCCCccccccHHHHHHHHHHHHHHhcCCCCCCCCeeeEEEEcCCCCHHHHHHHHHH Confidence 35677899999999997321112235433223456788999999999999877777899999999988775544433333 Q NP_000836.2 119 FVQALIE--KDASDVKCANGDPPIF-TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 119 ~~~~l~~--~~~~~~~~~~~~~~~~-~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) ++..... .......|...++.+. ...++++++||+.++.....++.++...++|+|++.+..+.+.++..+++++++ T Consensus 107 l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~ 186 (503) T 5CNJ_A 107 FVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFART 186 (503) T ss_dssp GTTTTC----------------------CCCEEEEEECSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTCTTEEES T ss_pred HHHHHhccCCCCCceeCCCCccccCCCCCCceEEEEcCCCcHHHHHHHHHHHHhCCCEEecCcCCccccCCccCCceeee Confidence 3321000 0000000000000000 001468899998887777778888899999999988766655443357889999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) .++....+.++++++++++|++|++++.+++++....+.+++.+++. ++++.....++......++...++++.+..++ T Consensus 187 ~p~~~~~~~a~~~~l~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 265 (503) T 5CNJ_A 187 VPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARAR-NISVATSEKVGRAMSRAAFEGVVRALLQKPSA 265 (503) T ss_dssp SCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECSSCCHHHHHHHHHHHHTSSSC T ss_pred CCChHHHHHHHHHHHHHcCCcEEEEEEeCCcchhHHHHHHHHHHHHC-CcEEEEEEecccccCHHHHHHHHHHHHcCCCc Confidence 99998889999999988899999999987778888888888887765 35554332232101223455666666422478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) |+|++......+..+++++++.|+ ++.|++.+.|...............|.+.+.......+.|..++....+...+. T Consensus 266 ~~iv~~~~~~~~~~~l~~~~~~g~--~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 343 (503) T 5CNJ_A 266 RVAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSR 343 (503) T ss_dssp CEEEEECCHHHHHHHHHHHHHTTC--CCEEEECTTTTTCHHHHTTCHHHHTTCEEEEECCCCCHHHHHHHHTCCTTTCTT T ss_pred eEEEEEcChHHHHHHHHHHHHhCC--CEEEEEeCccccchhHHccCcccccceEEEEeccccCccHHHHHhcCCCCCCCC Confidence 888887766677888888888776 356776654433211000011233344433322222222322222111111123 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS 435 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~ 435 (908) ..++.++|++.+.+.... ..|.... ... .......++..+|||++++++|+++.....+......|.... T Consensus 344 ~~~f~~~~~~~~~~~~~~--------~~~~~~~-~~~-~~~~~~~~~~~~yDav~~~a~al~~~~~~~~~~~~~~c~~~~ 413 (503) T 5CNJ_A 344 NPWFREFWEQRFRCSFRQ--------RDCAAHS-LRA-VPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMR 413 (503) T ss_dssp CTTHHHHHHHHTTCCGGG--------TCSTTCC-TTT-SCCCCCTTHHHHHHHHHHHHHHHHHHHHHHCCSCSSCCGGGS T ss_pred CHHHHHHHHHHhCCccCc--------ccCCCcc-ccc-CCccccccchHHHHHHHHHHHHHHHHHHHhCCCCCCcchhcC Confidence 345666666655442110 0111100 000 001123456789999999999999886543221112232211 Q NP_000836.2 436 TIDGKE-LLGYIRAVNFN------GSAGTPVTFNENGDAPGRYDIFQYQITN-KSTEYKVIGHWTNQLHLKVEDMQWAH 506 (908) Q Consensus 436 ~~~~~~-l~~~l~~~~f~------G~~G~~v~Fd~~G~~~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~~~~~~i~w~~ 506 (908) ..++.. +.+.|++.+|. |.+| .++||++|++...+.+++++..+ +...+++||.|+....++...+.|++ T Consensus 414 ~~~~~~~l~~~l~~~~f~~~~~~~g~tG-~i~fd~~g~r~~~~~i~~~~~~~~~~~~~~~vg~w~~~~~~~~~~~~w~~ 491 (503) T 5CNJ_A 414 PVNGRRLYKDFVLNVKFDAPFRPADTHN-EVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAS 491 (503) T ss_dssp SCCHHHCCCCCGGGCEEECTTCCTTCCC-EEECCTTSCCCCEEEEEEEEECTTSCEEEEEEEEEESSEEECGGGSTTC- T ss_pred ccCHHHHHHHHHHhCeecCCCCCCCCCC-cEEeCCCCCCCCeEEEEEEEEcCCCceEEEEEEEEccCcEEccccceecC Confidence 123333 44667777887 5788 89999999998888888887432 12358999999976555445678875 No 31 >5FBK_A Extracellular calcium-sensing receptor; membrane protein, G-protein coupled receptor; HET: NAG, CSO, TCR; 2.1A {Homo sapiens} Probab=99.81 E-value=3.8e-25 Score=252.03 Aligned_cols=460 Identities=32% Similarity=0.552 Sum_probs=275.6 Template_Neff=10.500 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGE----------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~----------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) ...+++++||+++|.++... ....|+... ..+.....|++.|++++|+++++++|+++++++.|+++++ T Consensus 53 ~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~~~~~a~~~in~~~~~~~g~~i~~~~~D~~~~~ 131 (568) T 5FBK_A 53 AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTV 131 (568) T ss_dssp EEECCSEEEEEEECSEEEECCCCCCCSSCCCCCCEEEEC-HHHHHHHHHHHHHHHHHHTCSSSSSSCCEEEEEEECTTCH T ss_pred eeecCCEEEEEeeeeeecccccCCCccCCCCcccceecc-cccHHHHHHHHHHHHHHhcCCCCCCCCEEeeEEEeCCCCH Confidence 45678999999999986431 123455422 2456788999999999999888888899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+- ..+.....+.+.+....++++++||+.++..+..++.++...++|+|++.+..+.+.+...+ T Consensus 132 ~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 207 (568) T 5FBK_A 132 SKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 207 (568) T ss_dssp HHHHHHHHHHTHHH----HHHHHTHHHHSCCCSCCCCEEEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTC T ss_pred HHHHHHHHHHHHhc----CcccCCccccccCCCCCCCeEEEEcCCCcHHHHHHHHHHhhhCCcEeccccCCcccCCcccC Confidence 54443333333210 00000000000011111357899998888777788888899999999988766555443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) ++++++.+++...+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++++ T Consensus 208 ~~~~~~~~~~~~~~~a~~~~~~~~~~~~v~vi~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~~~~~~~~~~~~~~~l 286 (568) T 5FBK_A 208 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEVI 286 (568) T ss_dssp TTEEESSCCTHHHHHHHHHHHHHTTCCSEEEEEESSTTHHHHHHHHHHHHHHT-TCCEEEEEEECTTCCHHHHHHHHHHH T ss_pred CceeecCCCchHHHHHHHHHHHHcCCcEEEEEEecCccchhHHHHHHHHHHHC-CeEEEEEEeecCCCCHHHHHHHHHHH Confidence 88999999998889999999988999999999977778888888888888775 46665433222101223455667777 Q NP_000836.2 270 LETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRSR 348 (908) Q Consensus 270 ~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~ 348 (908) +. .++|+|++.+....+..+++++++.|+.. ..|++.+.|....... ........+.+.+.........|..|.... T Consensus 287 ~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~f~~~~~~~ 364 (568) T 5FBK_A 287 QN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKV 364 (568) T ss_dssp HH-CCCCEEEEECCHHHHHHHHHHHHHTTCCS-CEEEECHHHHTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHTC T ss_pred Hh-CCCeEEEEEcCchhHHHHHHHHHHcCCCC-CEEEEehhhcccccccCccceeeeceEEEEEeccccCccHHHHHHhc Confidence 63 57899888877777888999988888753 4566665443321100 000111223333332222233333333221 Q NP_000836.2 349 TLANNRRNVWFAEFWEENFGCKLGSHGK----------------------RNSHIKKCTGLERIAR----DSSYEQEGKV 402 (908) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~~c~~~~~~~~----~~~~~~~~~~ 402 (908) .+.......++.++|++.+.|....... ...+...|+..+.... ........++ T Consensus 365 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~a 444 (568) T 5FBK_A 365 HPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 444 (568) T ss_dssp CTTTCSSBTTHHHHHHHHHTCBC-------------------------------CCBCCSCCCGGGSCCTTTCCSCBSHH T ss_pred CCccCCCChhHHHHHHHHhCCccCCCCCCCCCchhcccCccccCCccCCCCcCCCCCCCCCCCcccCCCCcccccccchH Confidence 1111112223445555544442210000 0001112322111000 0001123567 Q NP_000836.2 403 QFVIDAVYSMAYALHNMHKDLCPG---YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQIT 479 (908) Q Consensus 403 ~~~yDAv~~la~Al~~~~~~~~~~---~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~ 479 (908) .++||||+++++|++++....+.. ....|.......+..+.+.|++.+|.|.+|+.|+||++|+|...+.|++++.. T Consensus 445 ~~~yDaV~~~a~al~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG~~v~fd~~g~r~~~~~I~~~~~~ 524 (568) T 5FBK_A 445 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLS 524 (568) T ss_dssp HHHHHHHHHHHHHHHHHHTCCTTSSSSGGGCCCCGGGCCHHHHHHHHHTCEEECTTSCEEECCTTSCCCCCEEEEEEEEC T ss_pred HHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCcccccccCHHHHHHHHhcCeeecCCCCEEEeCCCCCCCccEEEEEEEEc Confidence 899999999999999987543321 01223221122344577888888999988657999999999888999888743 Q NP_000836.2 480 N--KSTEYKVIGHWTNQL------HLKVEDMQWAHR 507 (908) Q Consensus 480 ~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~ 507 (908) . +...++.||.|+... .++...+.|.++ T Consensus 525 ~~~~~~~~~~vg~~~~~~~~~~~l~~~~~~i~w~~g 560 (568) T 5FBK_A 525 PEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGF 560 (568) T ss_dssp TTTCSEEEEEEEEECTTSCTTSSEEECGGGCCBTTT T ss_pred CCCCcEEEEEEEEEEccccCCCeEEEeccceeecCC Confidence 1 112588999998652 122335777654 No 32 >5FBK_B Extracellular calcium-sensing receptor; membrane protein, G-protein coupled receptor; HET: TCR, NAG, CSO; 2.1A {Homo sapiens} Probab=99.81 E-value=4.7e-25 Score=251.32 Aligned_cols=460 Identities=32% Similarity=0.552 Sum_probs=272.9 Template_Neff=10.500 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGE----------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~----------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) ....++++||+++|.++... ....|+... ..+.....|++.|++++|+++++++|+++++++.|+++++ T Consensus 53 ~~~~~~i~Ig~l~p~~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~~~~~a~~~in~~~~~~~g~~i~~~~~D~~~~~ 131 (568) T 5FBK_B 53 AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTV 131 (568) T ss_dssp EEECCSEEEEEEECSEEEECCCCCCCSSCCCCCCEEEEC-HHHHHHHHHHHHHHHHHHTCSSSSSSCCEEEEEEECTTCH T ss_pred eeecCCEEEEEEeeeeecccccCCCccCCCCcccceecc-cchHHHHHHHHHHHHHHhcCCCCCCCCEEeEEEEeCCCCH Confidence 45678999999999986431 123455422 2456788999999999999888888899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+- +.+.....+.+.+....++++++||+.++..+..++.++...++|+|++.+..+.+.+...+ T Consensus 132 ~~a~~~~~~l~~~~----~~~~~~~~~~~~~~~~~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 207 (568) T 5FBK_B 132 SKALEATLSFVAQN----KIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 207 (568) T ss_dssp HHHHHHHHHHTHHH----HHCC---------------EEEEECCSSHHHHHHHHHHHGGGTCCEEESSCCCGGGGCTTTC T ss_pred HHHHHHHHHHHHhc----CcccCCccccccCCCCCCCeEEEEcCCCcHHHHHHHHHHhhhCCcEeccccCCcccCCcccC Confidence 54443333333210 00000000000011111357899998888777788888999999999988766555443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) ++++++.+++...+.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+.......++...++++ T Consensus 208 ~~~~~~~~~~~~~~~a~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-gi~v~~~~~~~~~~~~~~~~~~~~~l 286 (568) T 5FBK_B 208 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER-DICIDFSELISQYSDEEEIQHVVEVI 286 (568) T ss_dssp TTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHT-TCEEEEEEEECTTCCHHHHHHHHHHH T ss_pred CceeecCCCcHHHHHHHHHHHHHcCCeEEEEEEeCCccchhHHHHHHHHHHHC-CeEEEEEEeecCCCCHHHHHHHHHHH Confidence 88999999998889999999988999999999977778888888888888775 46665433222101223455667777 Q NP_000836.2 270 LETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPV-YQQEEIAEGAVTILPKRASIDGFDRYFRSR 348 (908) Q Consensus 270 ~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~ 348 (908) +. .++|+|++.+....+..+++++++.|+.. ..|+..+.|....... ........+.+.+.........|..|.... T Consensus 287 ~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~i~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~f~~~~~~~ 364 (568) T 5FBK_B 287 QN-STAKVIVVFSSGPDLEPLIKEIVRRNITG-KIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKV 364 (568) T ss_dssp HH-CCCCEEEEECCHHHHHHHHHHHHHTTCCC-CEEEECHHHHTCTTTCCGGGHHHHTTCEEEEECCBCCTTHHHHHHTC T ss_pred Hh-CCCeEEEEecCchhHHHHHHHHHHcCCCC-CEEEEechhcccccccCccceeeeccEEEEEecCCcCchHHHHHHhc Confidence 63 57899888877777888999988888753 4566655443321100 000111223333322222233333332221 Q NP_000836.2 349 TLANNRRNVWFAEFWEENFGCKLGSHGK----------------------RNSHIKKCTGLERIAR----DSSYEQEGKV 402 (908) Q Consensus 349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------------------~~~~~~~c~~~~~~~~----~~~~~~~~~~ 402 (908) .+.......++.++|++.+.|....... ...+...|+..+.... ........++ T Consensus 365 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~a 444 (568) T 5FBK_B 365 HPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 444 (568) T ss_dssp CTTTCSSBTTHHHHHHHHHTCBCC-----------------------------CCCBCCSCCCGGGSCCTTTCCSCBSHH T ss_pred CCccCCCChhHHHHHHHHhCCccCCCCCCCCCchhcccCCcccCCccCCCCCCCCCCCCCCCCcccCCCCcccccccchH Confidence 1111112223445555544442210000 0001112322111000 0001123567 Q NP_000836.2 403 QFVIDAVYSMAYALHNMHKDLCPG---YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQIT 479 (908) Q Consensus 403 ~~~yDAv~~la~Al~~~~~~~~~~---~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~ 479 (908) .++||||+++++|++++....+.. ....|.......+..+.+.|++.+|.|.+|+.|+||++|+|...+.|++++.. T Consensus 445 ~~~yDaV~~~a~al~~~~~~~~~~~~~~~~~c~~~~~~~~~~l~~~l~~~~f~G~tG~~v~f~~~G~r~~~~~I~~~~~~ 524 (568) T 5FBK_B 445 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLS 524 (568) T ss_dssp HHHHHHHHHHHHHHHHHHTCCTTSSSSGGGCCCCGGGCCHHHHHHHHHTCCEECTTSCEECCCTTSCCCCCEEEEEEEEC T ss_pred HHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCcccccccCHHHHHHHHhhCeeecCCCCEEEeCCCCCCCCcEEEEEEEEc Confidence 899999999999999987543321 01223221122344577888888999988757999999999888999888743 Q NP_000836.2 480 N--KSTEYKVIGHWTNQL------HLKVEDMQWAHR 507 (908) Q Consensus 480 ~--~~~~~~~Vg~~~~~~------~~~~~~i~w~~~ 507 (908) . +...++.||.|+... .++...+.|.++ T Consensus 525 ~~~~~~~~~~vg~~~~~~~~~~~l~~~~~~i~W~~g 560 (568) T 5FBK_B 525 PEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGF 560 (568) T ss_dssp TTTSSEEEEEEEEECTTSCTTSSEEECGGGCCCC-- T ss_pred CCCCcEEEEEEEEEEeeccCCCeEEEeccceeccCC Confidence 1 112588999998652 122335778654 No 33 >1DP4_A ATRIAL NATRIURETIC PEPTIDE RECEPTOR A; periplasmic binding protein fold, dimer; HET: SO4, NAG; 2.0A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.79 E-value=2.8e-24 Score=236.57 Aligned_cols=369 Identities=15% Similarity=0.224 Sum_probs=238.8 Template_Neff=11.700 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-----SRDTYALEQSLT 118 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-----~~~~~a~~~~~~ 118 (908) ++++||+++|.++... ...+.....|+++|++++|+++++++|+++++++.|+. +++..+.+.+ T Consensus 1 ~~i~ig~~~p~~~~~~---------~~~~~~~~~~~~~A~~~in~~~~~~~~~~i~l~~~d~~~~~~~~~~~~~~~~~-- 69 (435) T 1DP4_A 1 SDLTVAVVLPLTNTSY---------PWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAA-- 69 (435) T ss_dssp CEEEEEEEECSSCCCS---------TTCHHHHHHHHHHHHHHHHTCTTSSTTCEEEEEEEECBCTTSSBCTTHHHHHH-- T ss_pred CCeEEEEEcccCCCCC---------CcchhhhHHHHHHHHHHHHcCCCCCCCcEEEEEEcCCccccccccccchHHHH-- Confidence 3689999999987431 01266788999999999999887777899999988875 4433322222 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++. .++++++||+.++..+..++.++...++|+|++.+.++.+.++..+++++++.|+ T Consensus 70 --~~~~~------------------~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~p~ 129 (435) T 1DP4_A 70 --VDLKW------------------EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPS 129 (435) T ss_dssp --HHHHH------------------HHCCSEEECCCSHHHHHHHHHHHHHHTCCEEESCCCCGGGGCTTTSTTEEECSCC T ss_pred --HHHHH------------------hcCCCEEECCCCcccchhHHHHHhhcCCCEEecCCchhccCccceeeeeeeeCCC Confidence 22222 1578899999888777888899999999999988877666544457899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGES-----GVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~-----~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ....+.++++++++++|+++++|+.++.++.. ..+.+.+.+++ . ++++.....+. .+..++...+++++. T Consensus 130 ~~~~~~a~~~~~~~~~~~~v~ii~~~~~~g~~~~~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~~~~- 205 (435) T 1DP4_A 130 HVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERL-NITVNHQEFVE--GDPDHYPKLLRAVRR- 205 (435) T ss_dssp HHHHHHHHHHHHHHHTCCSEEEEEEECCSSSCCHHHHHHHHHHHHHHHHH-CCEEEEEEECT--TCGGGHHHHHHHHHH- T ss_pred HHHHHHHHHHHHHHHCCeEEEEEEEcCCCCCCceehHHHHHHHHHHHHHc-CCeeceeeecC--CCcchHHHHHHHHHh- Confidence 99899999999988999999999876665533 45666666654 3 35554332222 122345566666652 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAP----------V------YQQEEIAEGAVTILPKR 335 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~----------~------~~~~~~~~g~~~~~~~~ 335 (908) ++++|++......+..+++++++.|+.. .+.|+..+.+...... . ........+.+.+.... T Consensus 206 -~~~~iv~~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 284 (435) T 1DP4_A 206 -KGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKE 284 (435) T ss_dssp -HCSEEEEESCHHHHHHHHHHHHHTTCCTTTCEEEEECTTCTTSCSSCTTSCBCTTCCSSSCHHHHHHHGGGEEEEEECC T ss_pred -cccEEEEeCCHHHHHHHHHHHHHCCCCCCCEEEEEEEcCCcccccccCCCCCCCCcCCCCCCHHHHHHHHhceecccCC Confidence 5788888877778889999999888853 4677765533221000 0 00000111111110000 Q NP_000836.2 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYA 415 (908) Q Consensus 336 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~A 415 (908) ...+....|.+.+++.+...+ .|... ...+..++..+|||+++++.| T Consensus 285 ---------------~~~~~~~~f~~~~~~~~~~~~-----------~~~~~-------~~~~~~~~~~~yda~~~~~~a 331 (435) T 1DP4_A 285 ---------------PDNPEYLEFLKQLKLLADKKF-----------NFTVE-------DGLKNIIPASFHDGLLLYVQA 331 (435) T ss_dssp ---------------CCSHHHHHHHHHHHHHHHHHH-----------CCCCC-------CSGGGHHHHHHHHHHHHHHHH T ss_pred ---------------CCCHHHHHHHHHHHHHhhcCC-----------CCCcc-------cccccccHHHHHHHHHHHHHH Confidence 000111112222222111000 01000 012345678899999999999 Q NP_000836.2 416 LHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 416 l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++++....+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+.+++.. .+.++.||.|+.. T Consensus 332 l~~~~~~~~~----------~~~~~~l~~~l~~~~f~g~~G-~~~f~~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~ 397 (435) T 1DP4_A 332 VTETLAQGGT----------VTDGENITQRMWNRSFQGVTG-YLKIDRNGDRDTDFSLWDMDPE--TGAFRVVLNYNGT 397 (435) T ss_dssp HHHHHHTTCC----------TTCHHHHHHTTTTEEEEETTE-EEEECTTSBBCCCEEEEEECTT--TCCEEEEEEECTT T ss_pred HHHHHHcCCC----------CCCHHHHHHHHhcceEeecCe-eEEECCCCCccccEEEEEEcCC--CCeEEEEEEEecC Confidence 9988643210 124456778888889999999 8999999998877888888742 2468899999865 No 34 >1DP4_C ATRIAL NATRIURETIC PEPTIDE RECEPTOR A; periplasmic binding protein fold, dimer; HET: NAG, SO4; 2.0A {Rattus norvegicus} SCOP: c.93.1.1 Probab=99.79 E-value=2.8e-24 Score=236.57 Aligned_cols=369 Identities=15% Similarity=0.224 Sum_probs=238.8 Template_Neff=11.700 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-----SRDTYALEQSLT 118 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-----~~~~~a~~~~~~ 118 (908) ++++||+++|.++... ...+.....|+++|++++|+++++++|+++++++.|+. +++..+.+.+ T Consensus 1 ~~i~ig~~~p~~~~~~---------~~~~~~~~~~~~~A~~~in~~~~~~~~~~i~l~~~d~~~~~~~~~~~~~~~~~-- 69 (435) T 1DP4_C 1 SDLTVAVVLPLTNTSY---------PWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAA-- 69 (435) T ss_dssp CEEEEEEEECSSCCCS---------TTCHHHHHHHHHHHHHHHHTCTTSSTTCEEEEEEEECBCTTSSBCTTHHHHHH-- T ss_pred CCeEEEEEcccCCCCC---------CcchhhhHHHHHHHHHHHHcCCCCCCCcEEEEEEcCCccccccccccchHHHH-- Confidence 3689999999987431 01266788999999999999887777899999988875 4433322222 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++. .++++++||+.++..+..++.++...++|+|++.+.++.+.++..+++++++.|+ T Consensus 70 --~~~~~------------------~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~p~ 129 (435) T 1DP4_C 70 --VDLKW------------------EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPS 129 (435) T ss_dssp --HHHHH------------------HHCCSEEECCCSHHHHHHHHHHHHHHTCCEEESCCCCGGGGCTTTSTTEEECSCC T ss_pred --HHHHH------------------hcCCCEEECCCCcccchhHHHHHhhcCCCEEecCCchhccCccceeeeeeeeCCC Confidence 22222 1578899999888777888899999999999988877666544457899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGES-----GVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~-----~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ....+.++++++++++|+++++|+.++.++.. ..+.+.+.+++ . ++++.....+. .+..++...+++++. T Consensus 130 ~~~~~~a~~~~~~~~~~~~v~ii~~~~~~g~~~~~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~~~~- 205 (435) T 1DP4_C 130 HVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERL-NITVNHQEFVE--GDPDHYPKLLRAVRR- 205 (435) T ss_dssp HHHHHHHHHHHHHHHTCCSEEEEEEECCSSSCCHHHHHHHHHHHHHHHHH-CCEEEEEEECT--TCGGGHHHHHHHHHH- T ss_pred HHHHHHHHHHHHHHHCCeEEEEEEEcCCCCCCceehHHHHHHHHHHHHHc-CCeeceeeecC--CCcchHHHHHHHHHh- Confidence 99899999999988999999999876665533 45666666654 3 35554332222 122345566666652 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAP----------V------YQQEEIAEGAVTILPKR 335 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~----------~------~~~~~~~~g~~~~~~~~ 335 (908) ++++|++......+..+++++++.|+.. .+.|+..+.+...... . ........+.+.+.... T Consensus 206 -~~~~iv~~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 284 (435) T 1DP4_C 206 -KGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKE 284 (435) T ss_dssp -HCSEEEEESCHHHHHHHHHHHHHTTCCTTTCEEEEECTTCTTSCSSCTTSCBCTTCCSSSCHHHHHHHGGGEEEEEECC T ss_pred -cccEEEEeCCHHHHHHHHHHHHHCCCCCCCEEEEEEEcCCcccccccCCCCCCCCcCCCCCCHHHHHHHHhceecccCC Confidence 5788888877778889999999888853 4677765533221000 0 00000111111110000 Q NP_000836.2 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYA 415 (908) Q Consensus 336 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~A 415 (908) ...+....|.+.+++.+...+ .|... ...+..++..+|||+++++.| T Consensus 285 ---------------~~~~~~~~f~~~~~~~~~~~~-----------~~~~~-------~~~~~~~~~~~yda~~~~~~a 331 (435) T 1DP4_C 285 ---------------PDNPEYLEFLKQLKLLADKKF-----------NFTVE-------DGLKNIIPASFHDGLLLYVQA 331 (435) T ss_dssp ---------------CCSHHHHHHHHHHHHHHHHHH-----------CCCCC-------CSGGGHHHHHHHHHHHHHHHH T ss_pred ---------------CCCHHHHHHHHHHHHHhhcCC-----------CCCcc-------cccccccHHHHHHHHHHHHHH Confidence 000111112222222111000 01000 012345678899999999999 Q NP_000836.2 416 LHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 416 l~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++++....+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+.+++.. .+.++.||.|+.. T Consensus 332 l~~~~~~~~~----------~~~~~~l~~~l~~~~f~g~~G-~~~f~~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~ 397 (435) T 1DP4_C 332 VTETLAQGGT----------VTDGENITQRMWNRSFQGVTG-YLKIDRNGDRDTDFSLWDMDPE--TGAFRVVLNYNGT 397 (435) T ss_dssp HHHHHHTTCC----------TTCHHHHHHTTTTEEEEETTE-EEEECTTSBBCCCEEEEEECTT--TCCEEEEEEECTT T ss_pred HHHHHHcCCC----------CCCHHHHHHHHhcceEeecCe-eEEECCCCCccccEEEEEEcCC--CCeEEEEEEEecC Confidence 9988643210 124456778888889999999 8999999998877888888742 2468899999865 No 35 >5X2M_A Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: GLN, NAG; 2.206A {Oryzias latipes} Probab=99.78 E-value=4.3e-24 Score=237.04 Aligned_cols=419 Identities=24% Similarity=0.397 Sum_probs=256.0 Template_Neff=11.300 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGE------RGVPCGE-LKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS 107 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~------~~~~c~~-~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~ 107 (908) ..+.....+++++||+++|+++... ....|+. .....+.....|+++|++++|+++++++|+++++.+.|++. T Consensus 4 ~~~~~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~c~~~~~~~~g~~~~~a~~~A~~~iN~~~~~~~~~~i~~~~~d~~~ 83 (461) T 5X2M_A 4 DQTSEFHLRGDYLIGGLFNIHYVAAANFQRPQAIDCSSKLFILPNYRRFQMMRFSVEEINNSSSLLPNVSLGYQMFDHCS 83 (461) T ss_dssp --CBTTEECCSEEEEEEECCEECCCCCCSSCBCCCGGGSEECHHHHHHHHHHHHHHHHHHTCSSSSTTCCEEEEEEECSC T ss_pred ccceeeEecCCEEEEeEEEeeecccccCCCCCCcccccceecchhHHHHHHHHHHHHHHHcCCCCCCCCcceEEEEcCCC Confidence 3455678889999999999997632 1234553 11235667889999999999998878788999999999876 Q NP_000836.2 108 RDTYALEQ-SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 108 ~~~~a~~~-~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) +...+... .....++++.. ...+....++++++||+.++.....++.++...++|+|++.+..+.+.+. T Consensus 84 ~~~~~~~~~~~~~~~~l~~~----------~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~ 153 (461) T 5X2M_A 84 DIHSFPGIFKLLSVNDLIRP----------WEDASTGLPNAIGVVGPFTSTHALSIAPIFMTNLFPMVSYGCSGSVFSKE 153 (461) T ss_dssp STTCHHHHHHHHCSSSEECT----------TCC----CCSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCT T ss_pred CcchHHHHHHHHhcCCcCCc----------ccccCCCCCCeeEEECCCCcHHHHHHHHHHhhcCCCeecceecCcccCCc Confidence 54321110 01111222110 00000001478899999888777788888999999999988766555443 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....++ . ..++...+ T Consensus 154 ~~~~~~~~~~~~~~~~~~a~~~~l~~~~~~~v~vi~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~ 229 (461) T 5X2M_A 154 NLYPSFLRTVHSNKDVINAIVGIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIEDS-EICLAFYKAIN--V-NTDYLQVF 229 (461) T ss_dssp TTSTTEEESSCCHHHHHHHHHHHHHHSSBCEEEEEEESSHHHHHHHHHHHHHHTTS-SCEEEEEEEEC--T-TCCHHHHH T ss_pred ccCCceeeecCCCHHHHHHHHHHHHHcCCcEEEEEEeCChhhHHHHHHHHHHHHhc-CcEEEEEEeeC--C-CccHHHHH Confidence 35788999999999999999999988999999999987778888888888887775 46665433332 1 23466677 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVY-QQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~-~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++......+..+++++++.|+. .+.|+..+.|........ .......+.+.+.......+.+..++ T Consensus 230 ~~i~~-~~~~~iv~~~~~~~~~~~l~~~~~~g~~-~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 307 (461) T 5X2M_A 230 KQIEE-QNIKVIVVFAPKVYAEAVVESAVQLNVT-NKVWIADDGWSLNKKLPSMNGIQNIGTVLGVAQPVVTIPGFTDFI 307 (461) T ss_dssp HHHHH-TTCCEEEEECCHHHHHHHHHHHHHTTCC-SEEEEECTTTTTCSSGGGSTTGGGGEEEEEEECCCCCCTTHHHHH T ss_pred HHHHh-CCCeEEEEECChHHHHHHHHHHHHcCCC-CcEEEEechhhcCCccccCCccceeccEEEEeccceeCCCHHHHH Confidence 77763 5789988887777788999999988875 356666554432211000 00011122222211111111122111 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ............+..++++..+.|. .... .. .......++..+|||++++++|++++..+.. T Consensus 308 ~~~~~~~~~~~~~~~~~~~~~~~~~---------------~~~~-~~-~~~~~~~~~~~~yDav~~~a~a~~~~~~~~~- 369 (461) T 5X2M_A 308 YSAISQTDGGDTEQKMFCNQKCNCS---------------NLSV-KS-LLNADPSFSFPVYAAVYAIAHALHNTLRCGS- 369 (461) T ss_dssp HHHHTC---------CCTTCCCCCT---------------TCCH-HH-HHTSCCTTHHHHHHHHHHHHHHHHHHHTCCS- T ss_pred HhcccccCCCChhHHHHhcccCCCC---------------cccc-hh-hccCCCccHHHHHHHHHHHHHHHHHHhhcCC- Confidence 1000000000111111111111110 0000 00 0011234678899999999999998864321 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..|......++..+.+.|++..|.|.+| .+.|+++|++. ..+.+++++. ++.++.||.|+.. T Consensus 370 ---~~~~~~~~~~~~~l~~~l~~~~f~g~~G-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~~~~~ 432 (461) T 5X2M_A 370 ---DRCPKNITVHPHMILEELKKSNFTLLNQ-TVQFDENGDPKFGSLSVVFWNS---SGNAEEVGSYHFQ 432 (461) T ss_dssp ---SCCCCSCCCCHHHHHHHHHTCCEEETTE-EECBCTTSCBSCCCEEEEEECT---TSCEEEEEEECSS T ss_pred ---CCCCccCCCCHHHHHHHHhcCcEEeCCc-eEEECCCCCCCCccEEEEEEeC---CCCEEEEEEEEcC Confidence 1121111234556778888889999988 89999999886 6788888873 2478899999865 No 36 >5X2N_C Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: ALA, NAG; 2.2A {Oryzias latipes} Probab=99.78 E-value=4.3e-24 Score=237.04 Aligned_cols=419 Identities=24% Similarity=0.397 Sum_probs=256.5 Template_Neff=11.300 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGE------RGVPCGE-LKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS 107 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~------~~~~c~~-~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~ 107 (908) ..+.....+++++||+++|+++... ....|+. .....+.....|+++|++++|+++++++|+++++.+.|++. T Consensus 4 ~~~~~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~c~~~~~~~~g~~~~~a~~~A~~~iN~~~~~~~~~~i~~~~~d~~~ 83 (461) T 5X2N_C 4 DQTSEFHLRGDYLIGGLFNIHYVAAANFQRPQAIDCSSKLFILPNYRRFQMMRFSVEEINNSSSLLPNVSLGYQMFDHCS 83 (461) T ss_dssp --CCTTEECCSEEEEEEECCEECCCCCCSSSBCCCGGGSEECHHHHHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEECSC T ss_pred ccceeeEecCCEEEEeEEEeeecccccCCCCCCcccccceecchhHHHHHHHHHHHHHHHcCCCCCCCCcceEEEEcCCC Confidence 3455678889999999999997632 1234553 11235667889999999999998878788999999999876 Q NP_000836.2 108 RDTYALEQ-SLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186 (908) Q Consensus 108 ~~~~a~~~-~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~ 186 (908) +...+... .....++++.. ...+....++++++||+.++.....++.++...++|+|++.+..+.+.+. T Consensus 84 ~~~~~~~~~~~~~~~~l~~~----------~~~~~~~~~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~ 153 (461) T 5X2N_C 84 DIHSFPGIFKLLSVNDLIRP----------WEDASTGLPNAIGVVGPFTSTHALSIAPIFMTNLFPMVSYGCSGSVFSKE 153 (461) T ss_dssp GGGCHHHHHHHHCBTTEECT----------TCC-CCCCCSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCT T ss_pred CcchHHHHHHHHhcCCcCCc----------ccccCCCCCCeeEEECCCCcHHHHHHHHHHhhcCCCeecceecCcccCCc Confidence 54321110 01111222110 00000001478899999888777788888999999999988766555443 Q NP_000836.2 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 187 ~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) ..+++++++.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....++ . ..++...+ T Consensus 154 ~~~~~~~~~~~~~~~~~~a~~~~l~~~~~~~v~vi~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~ 229 (461) T 5X2N_C 154 NLYPSFLRTVHSNKDVINAIVGIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIEDS-EICLAFYKAIN--V-NTDYLQVF 229 (461) T ss_dssp TTCTTEEESSCCHHHHHHHHHHHHHTSSBCEEEEEEESSHHHHHHHHHHHHHHTTS-SCEEEEEEEEC--T-TCCHHHHH T ss_pred ccCCceeeecCCCHHHHHHHHHHHHHcCCcEEEEEEeCChhhHHHHHHHHHHHHhc-CcEEEEEEeeC--C-CccHHHHH Confidence 35788999999999999999999988999999999987778888888888887775 46665433332 1 23466677 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVY-QQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~-~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++......+..+++++++.|+. .+.|+..+.|........ .......+.+.+.......+.+..++ T Consensus 230 ~~i~~-~~~~~iv~~~~~~~~~~~l~~~~~~g~~-~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 307 (461) T 5X2N_C 230 KQIEE-QNIKVIVVFAPKVYAEAVVESAVQLNVT-NKVWIADDGWSLNKKLPSMNGIQNIGTVLGVAQPVVTIPGFTDFI 307 (461) T ss_dssp HHHHH-TTCCEEEEECCHHHHHHHHHHHHHTTCC-SEEEEECTTTTTCSSGGGSTTGGGGEEEEEEECCCCCCTTHHHHH T ss_pred HHHHh-CCCeEEEEECChHHHHHHHHHHHHcCCC-CcEEEEechhhcCCccccCCccceeccEEEEeccceeCCCHHHHH Confidence 77763 5789988887777788999999988875 356666554432211000 00011122222211111111122111 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) ............+..++++..+.|. .... .. .......++..+|||++++++|++++..+.. T Consensus 308 ~~~~~~~~~~~~~~~~~~~~~~~~~---------------~~~~-~~-~~~~~~~~~~~~yDav~~~a~a~~~~~~~~~- 369 (461) T 5X2N_C 308 YSAISQTDGGDTEQKMFCNQKCNCS---------------NLSV-KS-LLNADPSFSFPVYAAVYAIAHALHNTLRCGS- 369 (461) T ss_dssp HHHHCC-------CCCCTTCCCCCC---------------SCCH-HH-HHTSCCTTHHHHHHHHHHHHHHHHHHTTCCS- T ss_pred HhcccccCCCChhHHHHhcccCCCC---------------cccc-hh-hccCCCccHHHHHHHHHHHHHHHHHHhhcCC- Confidence 1000000000111111111111110 0000 00 0011234678899999999999998864321 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..|......++..+.+.|++..|.|.+| .+.|+++|++. ..+.+++++. ++.++.||.|+.. T Consensus 370 ---~~~~~~~~~~~~~l~~~l~~~~f~g~~G-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~~~~~ 432 (461) T 5X2N_C 370 ---DRCPKNITVHPHMILEELKKSNFTLLNQ-TVQFDENGDPKFGSLSVVFWNS---SGNAEEVGSYHFQ 432 (461) T ss_dssp ---SCCCSSCCCCHHHHHHHHHTCCEEETTE-EECBCTTSCBSCCCEEEEEECT---TSCEEEEEEECSS T ss_pred ---CCCCccCCCCHHHHHHHHhcCcEEeCCc-eEEECCCCCCCCccEEEEEEeC---CCCEEEEEEEEcC Confidence 1121111234556778888889999988 89999999886 6788888873 2478899999865 No 37 >5X2M_B Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: GLN, NAG; 2.206A {Oryzias latipes} Probab=99.76 E-value=1.5e-23 Score=233.83 Aligned_cols=440 Identities=23% Similarity=0.419 Sum_probs=263.9 Template_Neff=11.200 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGE---------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~---------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) .....++++||+++|.++... ....|+... ..+.....|+++|++++|+++++++|+++++++.|+++++ T Consensus 12 ~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~ 90 (478) T 5X2M_B 12 LFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLN-KDGLGRALVMKYAVEEINANSQLLPGVKLGYKIYNTCRHS 90 (478) T ss_dssp SSEECCSEEEEEEECCEECC------------CCCCEEC-HHHHHHHHHHHHHHHHHHHCTTTSTTCCEEEEEEECTTCH T ss_pred ccccCCCEEEEEEEeccccCCcccccccccCCCcccccc-chhHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEccCCCH Confidence 356678999999999987532 123465432 3467788999999999999888877899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+.... .... .+.....+++++++||+.++.....++.++...++|+|++....+.+.+...+ T Consensus 91 ~~~~~~~~~l~~~~~~~-~~~~-----~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 164 (478) T 5X2M_B 91 AVIVRPALSFLTEKSNG-TLSV-----ECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSDSLVY 164 (478) T ss_dssp HHHHHHHHHTTSBTTTS-SEEC-----CSBCTTCCBSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTS T ss_pred HHHHHHHHHHHhhccCC-cccc-----ccCCCCCCCCeEEEEcCCCHHHHHHHHHHHHhhCCcEeecCCCCcccCCCccc Confidence 54433333333210000 0000 00000001578899998888777778888899999999988766655443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKR 268 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~ 268 (908) ++++++.++....+.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+... ....++...+++ T Consensus 165 ~~~~~~~~~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~ 243 (478) T 5X2M_B 165 PSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDM-GVCVAYQGLIPIYDDPKPAIQTIINN 243 (478) T ss_dssp TTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSSCCHHHHHHHHHH T ss_pred cceeecCCCcHHHHHHHHHHHHHcCCeEEEEEecCCHHHHHHHHHHHHHHHHc-CcEEEEEeeecCCCCChHHHHHHHHH Confidence 89999999998899999999988999999999987778888888888888765 4555433222210 112345566677 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQ-QEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~-~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++|+|++......+..+++++++.|+. ..|++.+.|......... ......+.+.+.........+ T Consensus 244 l~~-~~~~~ivl~~~~~~~~~~l~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 314 (478) T 5X2M_B 244 IQT-TEVKVVVVFSLVSPAVSFFEEVIKKNLT--GVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELL------ 314 (478) T ss_dssp HHH-HTCSEEEEECCHHHHHHHHHHHHHTTCC--EEEEECTTTTTCHHHHTSTTGGGSEEEEEEEECCCCCTTH------ T ss_pred Hhc-CCCeEEEEEccChhHHHHHHHHHHcCCc--eeEEEecchhcccchhcCCCcccccceEEEEecccccccc------ Confidence 763 5788888877677788889999888874 356666544332110000 011112222211110000000 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARD-----SSYEQEGKVQFVIDAVYSMAYALHNMHKD 422 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~-----~~~~~~~~~~~~yDAv~~la~Al~~~~~~ 422 (908) .+....|.+.+.+.+...... .....|......... .......++..+|||++++++|+++.... T Consensus 315 -----~~~~~~f~~~~~~~~~~~~~~-----~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ydav~~~a~al~~~~~~ 384 (478) T 5X2M_B 315 -----SPFTEVLFKKIHEASPTEKPE-----DPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLEC 384 (478) T ss_dssp -----HHHHHHHHHHHHHTTTC-----------CCSCGGGGGCCGGGGHHHHSHHHHTTHHHHHHHHHHHHHHHHHHTTC T ss_pred -----cHHHHHHHHHHHHcCCCCCCC-----CCCCCCCCccccCCCCcccccccccchHHHHHHHHHHHHHHHHHHHhcC Confidence 000111111111111100000 000011110000000 00123456778999999999999988753 Q NP_000836.2 423 LCPGYIGLCPRM--STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL-HLKV 499 (908) Q Consensus 423 ~~~~~~~~~~~~--~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~-~~~~ 499 (908) .+. .|... ...+++.+.+.|++.+|.|.+| .+.||++|++...+.+++++.. ++.++.||.|+... .++. T Consensus 385 ~~~----~c~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~fd~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~~l~~~~ 457 (478) T 5X2M_B 385 NSA----ACKWSSSTRLYPWKLLEVLKEFSVNISNT-SLKFDQNGNPNIGYSVIQRIWE--NQSLSSVGSYRSANLSINE 457 (478) T ss_dssp CSS----CCSCCTTCCCCHHHHHHHHTTCEEEETTE-EEEBCTTSCBSCCEEEEEEETT--TTEEEEEEEEETTEEEECG T ss_pred CCC----cCCcccccCCCHHHHHHHHHhCeEecCCC-eEEECCCCCCCCceEEEEEEeC--CCeeEEEEEEecccceEec Confidence 321 12110 1134556778888888999888 8999999998888888887642 25789999998652 3333 Q NP_000836.2 500 EDMQWAHREHTHP 512 (908) Q Consensus 500 ~~i~w~~~~~~~p 512 (908) ..+.|.++...+| T Consensus 458 ~~~~w~~~~~~~p 470 (478) T 5X2M_B 458 TLFKWYTNNSEKP 470 (478) T ss_dssp GGCCCCSTTSSCC T ss_pred cceeeecCCCCCC Confidence 4577875433344 No 38 >5X2N_B Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: ALA, NAG; 2.2A {Oryzias latipes} Probab=99.76 E-value=1.5e-23 Score=233.83 Aligned_cols=440 Identities=23% Similarity=0.419 Sum_probs=264.3 Template_Neff=11.200 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGE---------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~---------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) .....++++||+++|.++... ....|+... ..+.....|+++|++++|+++++++|+++++++.|+++++ T Consensus 12 ~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~ 90 (478) T 5X2N_B 12 LFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLN-KDGLGRALVMKYAVEEINANSQLLPGVKLGYKIYNTCRHS 90 (478) T ss_dssp SSEECCSEEEEEEECCEECCC-----------CCCCEEC-HHHHHHHHHHHHHHHHHHHCTTTSTTCCEEEEEEECTTCH T ss_pred ccccCCCEEEEEEEeccccCCcccccccccCCCcccccc-chhHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEccCCCH Confidence 356678999999999987532 123465432 3467788999999999999888877899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+.... .... .+.....+++++++||+.++.....++.++...++|+|++....+.+.+...+ T Consensus 91 ~~~~~~~~~l~~~~~~~-~~~~-----~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 164 (478) T 5X2N_B 91 AVIVRPALSFLTEKSNG-TLSV-----ECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSDSLVY 164 (478) T ss_dssp HHHHHHHHHTTSBTTTS-SEEC-----CSBCTTCCBSCSEEECCSSHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTS T ss_pred HHHHHHHHHHHhhccCC-cccc-----ccCCCCCCCCeEEEEcCCCHHHHHHHHHHHHhhCCcEeecCCCCcccCCCccc Confidence 54433333333210000 0000 00000001578899998888777778888899999999988766655443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKR 268 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~ 268 (908) ++++++.++....+.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+... ....++...+++ T Consensus 165 ~~~~~~~~~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~ 243 (478) T 5X2N_B 165 PSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDM-GVCVAYQGLIPIYDDPKPAIQTIINN 243 (478) T ss_dssp TTEEESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSSCCHHHHHHHHHH T ss_pred cceeecCCCcHHHHHHHHHHHHHcCCeEEEEEecCCHHHHHHHHHHHHHHHHc-CcEEEEEeeecCCCCChHHHHHHHHH Confidence 89999999998899999999988999999999987778888888888888765 4555433222210 112345566677 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQ-QEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~-~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++|+|++......+..+++++++.|+. ..|++.+.|......... ......+.+.+.........+ T Consensus 244 l~~-~~~~~ivl~~~~~~~~~~l~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 314 (478) T 5X2N_B 244 IQT-TEVKVVVVFSLVSPAVSFFEEVIKKNLT--GVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELL------ 314 (478) T ss_dssp HHH-HTCSEEEEECCHHHHHHHHHHHHHTTCC--EEEEECTTTTTCHHHHTSTTGGGSEEEEEEEECCCCCTTH------ T ss_pred Hhc-CCCeEEEEEccChhHHHHHHHHHHcCCc--eeEEEecchhcccchhcCCCcccccceEEEEecccccccc------ Confidence 763 5788888877677788889999888874 356666544332110000 011112222211110000000 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARD-----SSYEQEGKVQFVIDAVYSMAYALHNMHKD 422 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~-----~~~~~~~~~~~~yDAv~~la~Al~~~~~~ 422 (908) .+....|.+.+.+.+...... .....|......... .......++..+|||++++++|+++.... T Consensus 315 -----~~~~~~f~~~~~~~~~~~~~~-----~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ydav~~~a~al~~~~~~ 384 (478) T 5X2N_B 315 -----SPFTEVLFKKIHEASPTEKPE-----DPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLEC 384 (478) T ss_dssp -----HHHHHHHHHHHHHHTTSCCC------CTTCSCGGGGGCCGGGTHHHHSHHHHTTHHHHHHHHHHHHHHHHHHTTC T ss_pred -----cHHHHHHHHHHHHcCCCCCCC-----CCCCCCCCccccCCCCcccccccccchHHHHHHHHHHHHHHHHHHHhcC Confidence 000111111111111100000 000011110000000 00123456778999999999999988753 Q NP_000836.2 423 LCPGYIGLCPRM--STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL-HLKV 499 (908) Q Consensus 423 ~~~~~~~~~~~~--~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~-~~~~ 499 (908) .+. .|... ...+++.+.+.|++.+|.|.+| .+.||++|++...+.+++++.. ++.++.||.|+... .++. T Consensus 385 ~~~----~c~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~fd~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~~l~~~~ 457 (478) T 5X2N_B 385 NSA----ACKWSSSTRLYPWKLLEVLKEFSVNISNT-SLKFDQNGNPNIGYSVIQRIWE--NQSLSSVGSYRSANLSINE 457 (478) T ss_dssp CSS----CCSCCTTCCCCHHHHHHHHTTCEEEETTE-EEEBCTTSCBSCCEEEEEEETT--TTEEEEEEEEETTEEEECG T ss_pred CCC----cCCcccccCCCHHHHHHHHHhCeEecCCC-eEEECCCCCCCCceEEEEEEeC--CCeeEEEEEEecccceEec Confidence 321 12110 1134556778888888999888 8999999998888888887642 25789999998652 3333 Q NP_000836.2 500 EDMQWAHREHTHP 512 (908) Q Consensus 500 ~~i~w~~~~~~~p 512 (908) ..+.|.++...+| T Consensus 458 ~~~~w~~~~~~~p 470 (478) T 5X2N_B 458 TLFKWYTNNSEKP 470 (478) T ss_dssp GGCCCCSTTSCCC T ss_pred cceeeecCCCCCC Confidence 4577875433344 No 39 >5X2N_D Taste receptor, type 1, member; receptor, ligand binding, amino acid; HET: NAG, ALA; 2.2A {Oryzias latipes} Probab=99.76 E-value=1.5e-23 Score=233.83 Aligned_cols=440 Identities=23% Similarity=0.419 Sum_probs=260.0 Template_Neff=11.200 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGE---------RGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD 109 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~---------~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~ 109 (908) .....++++||+++|.++... ....|+... ..+.....|+++|++++|+++++++|+++++++.|+++++ T Consensus 12 ~~~~~~~i~ig~l~p~~~~~~~~~~~~~~~~~~~c~~~~-~~~~~~~~a~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~ 90 (478) T 5X2N_D 12 LFSMPGDIKLGGLFPIKEQSNEVSNDLTKLNSVSCDSLN-KDGLGRALVMKYAVEEINANSQLLPGVKLGYKIYNTCRHS 90 (478) T ss_dssp SSEECCSEEEEEEECCEECCC---------CCCCCCEEC-HHHHHHHHHHHHHHHHHHHCTTSSTTCCEEEEEEECTTCH T ss_pred ccccCCCEEEEEEEeccccCCcccccccccCCCcccccc-chhHHHHHHHHHHHHHHHcCCCCCCCCeeeEEEEccCCCH Confidence 356678999999999987532 123465432 3467788999999999999888877899999999988775 Q NP_000836.2 110 TYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189 (908) Q Consensus 110 ~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~ 189 (908) ..+.+.+.+++.+.... .... .+.....+++++++||+.++.....++.++...++|+|++....+.+.+...+ T Consensus 91 ~~~~~~~~~l~~~~~~~-~~~~-----~~~~~~~~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~ 164 (478) T 5X2N_D 91 AVIVRPALSFLTEKSNG-TLSV-----ECNYTDYETDMVAVIGPQSSEMVTVIGKLLGFFLMPQISFGATSDKFSDSLVY 164 (478) T ss_dssp HHHHHHHHHTTSBTTTS-SEEC-----CSBCTTCCBSCSEEECCSCHHHHHHHHHHHHHTTCCEEESSCCCGGGGCTTTS T ss_pred HHHHHHHHHHHhhccCC-cccc-----ccCCCCCCCCeEEEEcCCCHHHHHHHHHHHHhhCCcEeecCCCCcccCCCccc Confidence 54433333333210000 0000 00000001578899998888777778888899999999988766655443357 Q NP_000836.2 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKR 268 (908) Q Consensus 190 ~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~ 268 (908) ++++++.++....+.++++++++++|++|++|+.++.++....+.+++.+++. ++++.....+... ....++...+++ T Consensus 165 ~~~~~~~~~~~~~~~al~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~ 243 (478) T 5X2N_D 165 PSFFRTVPSDIRQVDAMVQLIKKFNWNWVAVVGSEEEYGQQGVQQFSKKAEDM-GVCVAYQGLIPIYDDPKPAIQTIINN 243 (478) T ss_dssp TTEEESSCCHHHHHHHHHHHHTTTTCCCEEEEEESSHHHHHHHHHHHHHHTTT-TCCEEEEEEECSSSCCHHHHHHHHHH T ss_pred cceeecCCCcHHHHHHHHHHHHHcCCeEEEEEecCCHHHHHHHHHHHHHHHHc-CcEEEEEeeecCCCCChHHHHHHHHH Confidence 89999999998899999999988999999999987778888888888888765 4555433222210 112345566677 Q NP_000836.2 269 LLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQ-QEEIAEGAVTILPKRASIDGFDRYFRS 347 (908) Q Consensus 269 l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~-~~~~~~g~~~~~~~~~~~~~~~~~~~~ 347 (908) ++. .++|+|++......+..+++++++.|+. ..|++.+.|......... ......+.+.+.........+ T Consensus 244 l~~-~~~~~ivl~~~~~~~~~~l~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 314 (478) T 5X2N_D 244 IQT-TEVKVVVVFSLVSPAVSFFEEVIKKNLT--GVWIASSSWAISDKVYSLPNIDSIGTVIGFIDETETLELL------ 314 (478) T ss_dssp HHC-----CEEEECCHHHHHHHHHHHHHTTCC--EEEEECHHHHTCHHHHTSTTGGGGEEEEEEEECCCCCTTH------ T ss_pred Hhc-CCCeEEEEEccChhHHHHHHHHHHcCCc--eeEEEecchhcccchhcCCCcccccceEEEEecccccccc------ Confidence 763 5788888877677788889999888874 356666544332110000 011112222211110000000 Q NP_000836.2 348 RTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARD-----SSYEQEGKVQFVIDAVYSMAYALHNMHKD 422 (908) Q Consensus 348 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~-----~~~~~~~~~~~~yDAv~~la~Al~~~~~~ 422 (908) .+....|.+.+.+.+...... .....|......... .......++..+|||++++++|+++.... T Consensus 315 -----~~~~~~f~~~~~~~~~~~~~~-----~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ydav~~~a~al~~~~~~ 384 (478) T 5X2N_D 315 -----SPFTEVLFKKIHEASPTEKPE-----DPYNPCPECWSLSPANVSLVKEESVQRTAFSVYAAVYTVAHALHKLLEC 384 (478) T ss_dssp -----HHHHHHHHHHHHTC------------CTTCSCGGGGGCCGGGTHHHHSHHHHTTHHHHHHHHHHHHHHHHHHTTC T ss_pred -----cHHHHHHHHHHHHcCCCCCCC-----CCCCCCCCccccCCCCcccccccccchHHHHHHHHHHHHHHHHHHHhcC Confidence 000111111111111100000 000011110000000 00123456778999999999999988753 Q NP_000836.2 423 LCPGYIGLCPRM--STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL-HLKV 499 (908) Q Consensus 423 ~~~~~~~~~~~~--~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~-~~~~ 499 (908) .+. .|... ...+++.+.+.|++.+|.|.+| .+.||++|++...+.+++++.. ++.++.||.|+... .++. T Consensus 385 ~~~----~c~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~fd~~g~~~~~~~i~~~~~~--~~~~~~vg~~~~~~l~~~~ 457 (478) T 5X2N_D 385 NSA----ACKWSSSTRLYPWKLLEVLKEFSVNISNT-SLKFDQNGNPNIGYSVIQRIWE--NQSLSSVGSYRSANLSINE 457 (478) T ss_dssp CSS----CCSCCTTCCCCHHHHHHHHTTCEEEETTE-EEEBCTTSCBSCCEEEEEEETT--TTEEEEEEEEETTEEEECG T ss_pred CCC----cCCcccccCCCHHHHHHHHHhCeEecCCC-eEEECCCCCCCCceEEEEEEeC--CCeeEEEEEEecccceEec Confidence 321 12110 1134556778888888999888 8999999998888888887642 25789999998652 3333 Q NP_000836.2 500 EDMQWAHREHTHP 512 (908) Q Consensus 500 ~~i~w~~~~~~~p 512 (908) ..+.|.++...+| T Consensus 458 ~~~~w~~~~~~~p 470 (478) T 5X2N_D 458 TLFKWYTNNSEKP 470 (478) T ss_dssp GGCCCTTSCC--- T ss_pred cceeeecCCCCCC Confidence 4577875433344 No 40 >1JDN_A ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR; Natriuretic peptide receptor, dimer, allosteric; HET: NDG, BMA, FUC, MAN, NAG; 2.9A {Homo sapiens} SCOP: c.93.1.1 Probab=99.76 E-value=2e-23 Score=230.14 Aligned_cols=372 Identities=17% Similarity=0.238 Sum_probs=238.1 Template_Neff=11.600 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD----LLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~----il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ...++++||+++|.++... ..+.....|++.|++++|++++ +++|.++++.+.|+++++.. + T Consensus 5 ~~~~~i~Igv~~p~~~~~~----------~~~~~~~~~~~~a~~~~n~~~g~~~~~~~~~~i~~~~~d~~~~~~~----~ 70 (441) T 1JDN_A 5 LPPQKIEVLVLLPQDDSYL----------FSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRA----L 70 (441) T ss_dssp --CCCEEEEEEECSCTTST----------TCHHHHHHHHHHHHHHHTC-------CCSSCCEEEEEEECTTSHHH----H T ss_pred CCCCeEEEEEEccCCCCCC----------CcHHHHHHHHHHHHHHHhccCCCCcCCCCCCEEEEEEecCCCChHH----H Confidence 4567899999999987531 2456788999999999998764 35688899998888776432 2 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN-TRYDFFSRV 195 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~-~~~~~~~~~ 195 (908) .+.++++... ..++++++||+.++..+..++.++...++|+|++.+..+.+... ..+++++++ T Consensus 71 ~~~~~~l~~~----------------~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 134 (441) T 1JDN_A 71 FSLVDRVAAA----------------RGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRV 134 (441) T ss_dssp HHHHHHHHHT----------------TTCCCSEEECCCSHHHHHHHHHHHHHTTCCEEESCCCSGGGGCCSSTTTTEEEC T ss_pred HHHHHHHHHH----------------hCCCCCEEECCCCHHhHHHHHHHHhhcCCcEEEecccchhhccchhhcccceee Confidence 2233322210 01578999998888777788888999999999988766655443 346889999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESG---VEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~---~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) .++....++++++++++++|+++++++.++.++... .+.+++.+++. ++++... .+.. .+..++...+++++. T Consensus 135 ~~~~~~~~~~~~~~l~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~~-~~~~~~~~~~~~i~~- 210 (441) T 1JDN_A 135 APAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEE-GLHTSIY-SFDE-TKDLDLEDIVRNIQA- 210 (441) T ss_dssp SCCTHHHHHHHHHHHHHTTCCEEEEEEECCSSSCHHHHHHHHHHHHHHHH-TCEEEEE-EECT-TSCCCHHHHHHHHHT- T ss_pred ccCHHHHHHHHHHHHHHcCCeEEEEEEeCCcccceeeEEhhHHHHHHHHc-CCeeEEE-eccC-CCCCCHHHHHHHHHh- Confidence 999999999999999888999999999877766655 67777777765 4665532 2211 123456667777763 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSK-----IAPV-----YQQEEIAEGAVTILPKRASIDGF 341 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~-----~~~~-----~~~~~~~~g~~~~~~~~~~~~~~ 341 (908) . +++|++......+..+++++++.|+.. .+.|+..+..... .... ........+.+...... T Consensus 211 ~-~~~vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 283 (441) T 1JDN_A 211 S-ERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLR------ 283 (441) T ss_dssp T-CSEEEEECCHHHHHHHHHHHHHTTCTTSSSEEEEECGGGCGGGCCSCCCCSSTTHHHHHHHGGGEEEEEECC------ T ss_pred c-CcEEEEEcCHHHHHHHHHHHHHCCCCCCCEEEEEEeccCccccCCCCccCCCcCcHHHHHHHHHcchhcccC------ Confidence 3 788888777777888899998888754 3667665421110 0000 00000111111111000 Q NP_000836.2 342 DRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHK 421 (908) Q Consensus 342 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~ 421 (908) ...+....|.+.+++.+... . ..| ...+..++..+|||++++++|+++... T Consensus 284 ---------~~~~~~~~f~~~~~~~~~~~-~---------~~~----------~~~~~~~~~~~yDav~~~~~a~~~~~~ 334 (441) T 1JDN_A 284 ---------TVKPEFEKFSMEVKSSVEKQ-G---------LNM----------EDYVNMFVEGFHDAILLYVLALHEVLR 334 (441) T ss_dssp ---------CCCHHHHHHHHHHHHHHHHT-T---------CCC----------SCSCCHHHHHHHHHHHHHHHHHHHHHT T ss_pred ---------CCChhHHHHHHHHHHHHHhc-C---------CCc----------cccchhHHHHHHHHHHHHHHHHHHHHH Confidence 00011111222222111100 0 000 012345678899999999999999865 Q NP_000836.2 422 DLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 422 ~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+++++..+ ++.++.||.|+.. T Consensus 335 ~~~~----------~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~~~~-~g~~~~vg~~~~~ 395 (441) T 1JDN_A 335 AGYS----------KKDGGKIIQQTWNRTFEGIAG-QVSIDANGDRYGDFSVIAMTDVE-AGTQEVIGDYFGK 395 (441) T ss_dssp TTCC----------TTCHHHHHHHHSSEEEEETTE-EEEECTTSBBCCEEEEEEEEETT-TTEEEEEEEEETT T ss_pred cCCC----------CCCHHHHHHHhhcCeEeecce-eEEECCCCCccceEEEEEeecCC-CCeEEEEEEEECC Confidence 3211 123456777888889999998 89999999887778888876321 3578899999864 No 41 >1JDP_A ATRIAL NATRIURETIC PEPTIDE CLEARANCE RECEPTOR; hormone-receptor complex, natriuretic peptide receptor; HET: NAG, NDG; 2.0A {Homo sapiens} SCOP: c.93.1.1 Probab=99.76 E-value=2e-23 Score=230.14 Aligned_cols=372 Identities=17% Similarity=0.238 Sum_probs=239.1 Template_Neff=11.600 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD----LLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~----il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) ...++++||+++|.++... ..+.....|++.|++++|++++ +++|.++++.+.|+++++.. + T Consensus 5 ~~~~~i~Igv~~p~~~~~~----------~~~~~~~~~~~~a~~~~n~~~g~~~~~~~~~~i~~~~~d~~~~~~~----~ 70 (441) T 1JDP_A 5 LPPQKIEVLVLLPQDDSYL----------FSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRA----L 70 (441) T ss_dssp CCCCEEEEEEEECSSTTST----------TCHHHHHHHHHHHHHHHCC-----CCSCTTCEEEEEEEECTTSTHH----H T ss_pred CCCCeEEEEEEccCCCCCC----------CcHHHHHHHHHHHHHHHhccCCCCcCCCCCCEEEEEEecCCCChHH----H Confidence 4567899999999987531 2456788999999999998764 35688899998888776432 2 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN-TRYDFFSRV 195 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~-~~~~~~~~~ 195 (908) .+.++++... ..++++++||+.++..+..++.++...++|+|++.+..+.+... ..+++++++ T Consensus 71 ~~~~~~l~~~----------------~~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~ 134 (441) T 1JDP_A 71 FSLVDRVAAA----------------RGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRV 134 (441) T ss_dssp HHHHHHHHHT----------------TTCCCSEEECCCSHHHHHHHHHHHHHHTCCEEESCCCSGGGGCTTTTTTTEEEC T ss_pred HHHHHHHHHH----------------hCCCCCEEECCCCHHhHHHHHHHHhhcCCcEEEecccchhhccchhhcccceee Confidence 2233322210 01578999998888777788888999999999988766655443 346889999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESG---VEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~---~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) .++....++++++++++++|+++++++.++.++... .+.+++.+++. ++++... .+.. .+..++...+++++. T Consensus 135 ~~~~~~~~~~~~~~l~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~~-~~~~~~~~~~~~i~~- 210 (441) T 1JDP_A 135 APAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEE-GLHTSIY-SFDE-TKDLDLEDIVRNIQA- 210 (441) T ss_dssp SCCHHHHHHHHHHHHHHHTCCEEEEEEECCSSSCHHHHHHHHHHHHHHHH-TCEEEEE-EECT-TSCCCHHHHHHHHHH- T ss_pred ccCHHHHHHHHHHHHHHcCCeEEEEEEeCCcccceeeEEhhHHHHHHHHc-CCeeEEE-eccC-CCCCCHHHHHHHHHh- Confidence 999999999999999888999999999877766655 67777777765 4665532 2211 123456667777763 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSK-----IAPV-----YQQEEIAEGAVTILPKRASIDGF 341 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~-----~~~~-----~~~~~~~~g~~~~~~~~~~~~~~ 341 (908) . +++|++......+..+++++++.|+.. .+.|+..+..... .... ........+.+...... T Consensus 211 ~-~~~vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~------ 283 (441) T 1JDP_A 211 S-ERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLR------ 283 (441) T ss_dssp H-CSEEEEESCHHHHHHHHHHHHHTTCTTTTCEEEEECSSCCCSTTTCTTCCSSTTHHHHHHHGGGEEEEEECC------ T ss_pred c-CcEEEEEcCHHHHHHHHHHHHHCCCCCCCEEEEEEeccCccccCCCCccCCCcCcHHHHHHHHHcchhcccC------ Confidence 3 788888777777888899998888754 3667665421110 0000 00000111111111000 Q NP_000836.2 342 DRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHK 421 (908) Q Consensus 342 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~ 421 (908) ...+....|.+.+++.+... . ..| ...+..++..+|||++++++|+++... T Consensus 284 ---------~~~~~~~~f~~~~~~~~~~~-~---------~~~----------~~~~~~~~~~~yDav~~~~~a~~~~~~ 334 (441) T 1JDP_A 284 ---------TVKPEFEKFSMEVKSSVEKQ-G---------LNM----------EDYVNMFVEGFHDAILLYVLALHEVLR 334 (441) T ss_dssp ---------CCCHHHHHHHHHHHHHHHTT-T---------CCC----------CSSCCHHHHHHHHHHHHHHHHHHHHHH T ss_pred ---------CCChhHHHHHHHHHHHHHhc-C---------CCc----------cccchhHHHHHHHHHHHHHHHHHHHHH Confidence 00011111222222111100 0 000 012345678899999999999999865 Q NP_000836.2 422 DLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 422 ~~~~~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..+. ..++..+.+.|++..|.|.+| .+.|+++|++...+.+++++..+ ++.++.||.|+.. T Consensus 335 ~~~~----------~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~~~~-~g~~~~vg~~~~~ 395 (441) T 1JDP_A 335 AGYS----------KKDGGKIIQQTWNRTFEGIAG-QVSIDANGDRYGDFSVIAMTDVE-AGTQEVIGDYFGK 395 (441) T ss_dssp TTCC----------TTCHHHHHHHHSSEEEEETTE-EEEECTTSBBCCEEEEEEEEETT-TTEEEEEEEEETT T ss_pred cCCC----------CCCHHHHHHHhhcCeEeecce-eEEECCCCCccceEEEEEeecCC-CCeEEEEEEEECC Confidence 3211 123456777888889999998 89999999887778888876321 3578899999864 No 42 >4F11_A Gamma-aminobutyric acid type B receptor; Venus flytrap module, G-protein coupled; 2.38A {Homo sapiens} Probab=99.72 E-value=2e-22 Score=221.47 Aligned_cols=391 Identities=19% Similarity=0.262 Sum_probs=245.4 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++.... ...+.....|++.|++++|+.++ ++|+++++++.|+++++..+.+ T Consensus 8 ~~~~~~~i~ig~~~~~~~~~~~--------~~~~~~~~~~~~~a~~~~n~~~~-~~~~~i~l~~~d~~~~~~~~~~---- 74 (433) T 4F11_A 8 PPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNESL-LRPYFLDLRLYDTECDNAKGLK---- 74 (433) T ss_dssp ---CCCEEEEEEEECCCTTSTT--------HHHHHHHHHHHHHHHHHHHHTTT-TTTCEEEEEEEECTTCHHHHHH---- T ss_pred CCCCCCCeEEEEEEecCCcccC--------CcccccHHHHHHHHHHHHHhccC-CCCceEEEEEEcCCCChhHHHH---- Confidence 3456789999999999864310 02456788999999999998764 5578899999998876544333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+.+++.. .++++++||+.++..+..++.++...++|+|++.+..+.+.+...+++++++.++ T Consensus 75 ~~~~l~~~-----------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 137 (433) T 4F11_A 75 AFYDAIKY-----------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 137 (433) T ss_dssp HHHHHHHH-----------------SCCCSEEEECCSHHHHHHHHHTHHHHTCEEEESSCCCGGGGCTTTCTTEEESSCC T ss_pred HHHHHHHh-----------------CCCeEEEEcCCChhHHHHHHHHccccCCeEEEeccCCHHHcCCCCCCceeeeCCC Confidence 33333320 0368899998888777778888889999999988766655443357889999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ...++.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+. .++...+++++. .++++| T Consensus 138 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~~~~~~~~~~~~-~~~~~v 210 (433) T 4F11_A 138 DNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDVRII 210 (433) T ss_dssp GGGHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHSSSS-SCEEEEEEEES-----SCCHHHHHHHHH-TTCCEE T ss_pred hhhhhHHHHHHHHHcCCCEEEEEEecchhhHHHHHHHHHHHhcC-CeEEEeeeeec-----CChhHHHHHHhc-CCcEEE Confidence 98889999999988899999999987777777778888877765 46654332221 235556667763 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++.........+++++++.|+.. ++.|+..+ +........ .......+.+.+.........+..+ T Consensus 211 ~~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 289 (433) T 4F11_A 211 LGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTI 289 (433) T ss_dssp EEECCHHHHHHHHHHHHHTTCCSTTCEEEEES-CSCTTTTTCC------CCSCHHHHHHHHTTCEEEEECSSCCCCCCCT T ss_pred EEeCCHHHHHHHHHHHHHcCCcCCCeEEEccC-CcCcchhHHhhccccCCCccHHHHHHHHccceeeEeecCCCCCcccc Confidence 77766667788899988888753 45666654 221110000 0011122222221110000000000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ......+ +.+.+.+... ...+..++..+|||++++++|++++....+ T Consensus 290 ----------~~~~~~~-~~~~~~~~~~----------------------~~~~~~~~~~~ydav~~~~~al~~~~~~~~ 336 (433) T 4F11_A 290 ----------SGKTPQQ-YEREYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAMETLH 336 (433) T ss_dssp ----------TSCCHHH-HHHHHHHHHT----------------------TSCCCTTHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ----------CCCCHHH-HHHHHHHhcc----------------------CCChhhcchHHHHHHHHHHHHHHHHHHHHH Confidence 0000111 1111111000 012345678899999999999999875422 Q NP_000836.2 425 PGY---IGLCP-RMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL---HL 497 (908) Q Consensus 425 ~~~---~~~~~-~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~---~~ 497 (908) ... ...|. .....++..+.++|++..|.|.+| .+.|+ +|++...+.+++++ ++.++.||.|+... .+ T Consensus 337 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~i~f~-~g~~~~~~~i~~~~----~g~~~~v~~~~~~~~~~~~ 410 (433) T 4F11_A 337 ASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADTLEI 410 (433) T ss_dssp HSSSCCCGGGCSSCCHHHHHHHHHHHHTCEEEETTE-EEEEE-TTEEECEEEEEEEE----TTEEEEEEEEETTTTEEEE T ss_pred hcCCCCchhhcCCCChHHHHHHHHHHHcCcEEeece-eEEee-CCceeeEEEEEEEE----CCcEEEEEEEECCCCeEEE Confidence 100 00000 001124556778888889999999 89999 89987788888887 35789999998642 12 Q NP_000836.2 498 KVEDMQWAH 506 (908) Q Consensus 498 ~~~~i~w~~ 506 (908) ....+.|.+ T Consensus 411 ~~~~~~w~g 419 (433) T 4F11_A 411 INDTIRFQG 419 (433) T ss_dssp CTTTCCCSS T ss_pred ecCcccCCC Confidence 223466754 No 43 >4MS4_B Gamma-aminobutyric acid type B receptor; heterodimeric protein complex, Venus Flytrap; HET: NAG, 2C0; 1.9A {Homo sapiens} Probab=99.72 E-value=2e-22 Score=221.47 Aligned_cols=391 Identities=19% Similarity=0.262 Sum_probs=246.4 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++.... ...+.....|++.|++++|+.++ ++|+++++++.|+++++..+.+ T Consensus 8 ~~~~~~~i~ig~~~~~~~~~~~--------~~~~~~~~~~~~~a~~~~n~~~~-~~~~~i~l~~~d~~~~~~~~~~---- 74 (433) T 4MS4_B 8 PPPSSPPLSIMGLMPLTKEVAK--------GSIGRGVLPAVELAIEQIRNESL-LRPYFLDLRLYDTECDNAKGLK---- 74 (433) T ss_dssp -CTTCCEEEEEEEECCCTTSTT--------HHHHHHHHHHHHHHHHHHHHTTT-TTTCEEEEEEEECTTCHHHHHH---- T ss_pred CCCCCCCeEEEEEEecCCcccC--------CcccccHHHHHHHHHHHHHhccC-CCCceEEEEEEcCCCChhHHHH---- Confidence 3456789999999999864310 02456788999999999998764 5578899999998876544333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+.+++.. .++++++||+.++..+..++.++...++|+|++.+..+.+.+...+++++++.++ T Consensus 75 ~~~~l~~~-----------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 137 (433) T 4MS4_B 75 AFYDAIKY-----------------GPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 137 (433) T ss_dssp HHHHHHHH-----------------SCCCSEEEECCSHHHHHHHHHHGGGGTCEEEESSCCCGGGGCTTTCTTEEESSCC T ss_pred HHHHHHHh-----------------CCCeEEEEcCCChhHHHHHHHHccccCCeEEEeccCCHHHcCCCCCCceeeeCCC Confidence 33333320 0368899998888777778888889999999988766655443357889999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ...++.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+. .++...+++++. .++++| T Consensus 138 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~~~~~~~~~~~~-~~~~~v 210 (433) T 4MS4_B 138 DNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE-DIEISDTESFS-----NDPCTSVKKLKG-NDVRII 210 (433) T ss_dssp GGGHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHTTT-TCEEEEEEEES-----SCTHHHHHHHHH-TTCCEE T ss_pred hhhhhHHHHHHHHHcCCCEEEEEEecchhhHHHHHHHHHHHhcC-CeEEEeeeeec-----CChhHHHHHHhc-CCcEEE Confidence 98889999999988899999999987777777778888877765 46654332221 235556667763 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVY-------------QQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~-------------~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) ++.........+++++++.|+.. ++.|+..+ +........ .......+.+.+.........+..+ T Consensus 211 ~~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 289 (433) T 4MS4_B 211 LGQFDQNMAAKVFCCAYEENMYGSKYQWIIPG-WYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTI 289 (433) T ss_dssp EEECCHHHHHHHHHHHHHTTCCSTTCEEEEES-CSCTTTTC----------CCHHHHHHHHTTCEEEEECSSCCCCCCCT T ss_pred EEeCCHHHHHHHHHHHHHcCCcCCCeEEEccC-CcCcchhHHhhccccCCCccHHHHHHHHccceeeEeecCCCCCcccc Confidence 77766667788899988888753 45666654 221110000 0011122222221110000000000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) ......+ +.+.+.+... ...+..++..+|||++++++|++++....+ T Consensus 290 ----------~~~~~~~-~~~~~~~~~~----------------------~~~~~~~~~~~ydav~~~~~al~~~~~~~~ 336 (433) T 4MS4_B 290 ----------SGKTPQQ-YEREYNNKRS----------------------GVGPSKFHGYAYDGIWVIAKTLQRAMETLH 336 (433) T ss_dssp ----------TSSCHHH-HHHHHHHHCC----------------------SSCCCTTHHHHHHHHHHHHHHHHHHTCSSC T ss_pred ----------CCCCHHH-HHHHHHHhcc----------------------CCChhhcchHHHHHHHHHHHHHHHHHHHHH Confidence 0000111 1111111000 012345678899999999999999875422 Q NP_000836.2 425 PGY---IGLCP-RMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL---HL 497 (908) Q Consensus 425 ~~~---~~~~~-~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~---~~ 497 (908) ... ...|. .....++..+.++|++..|.|.+| .+.|+ +|++...+.+++++ ++.++.||.|+... .+ T Consensus 337 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~i~f~-~g~~~~~~~i~~~~----~g~~~~v~~~~~~~~~~~~ 410 (433) T 4MS4_B 337 ASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTG-QVVFR-NGERMGTIKFTQFQ----DSREVKVGEYNAVADTLEI 410 (433) T ss_dssp HHHHHHHHHHCCSCCHHHHHHHHHHHHTCEEEETTE-EEEEE-TTEEECEEEEEEEC----SSCEEEEEEEETTTTEEEE T ss_pred hcCCCCchhhcCCCChHHHHHHHHHHHcCcEEeece-eEEee-CCceeeEEEEEEEE----CCcEEEEEEEECCCCeEEE Confidence 100 00000 001124556778888889999999 89999 89987788888887 35789999998642 12 Q NP_000836.2 498 KVEDMQWAH 506 (908) Q Consensus 498 ~~~~i~w~~ 506 (908) ....+.|.+ T Consensus 411 ~~~~~~w~g 419 (433) T 4MS4_B 411 INDTIRFQG 419 (433) T ss_dssp CTTTCCCSS T ss_pred ecCcccCCC Confidence 223466754 No 44 >4MQE_A Gamma-aminobutyric acid type B receptor; heterodimeric protein complex, Venus Flytrap; HET: MAN, NAG, FUC; 2.35A {Homo sapiens} Probab=99.67 E-value=2e-21 Score=212.36 Aligned_cols=376 Identities=21% Similarity=0.283 Sum_probs=233.6 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++.. ..+.....|++.|++++|+.+++++|+++++.+.|+++++..+ .+.+.+ T Consensus 3 ~~~i~Ig~i~p~~~~~-----------~~~~~~~~~~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~~~~----~~~~~~ 67 (420) T 4MQE_A 3 RRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQA----TKYLYE 67 (420) T ss_dssp CEEEEEEEEECSSSSC-----------CTHHHHHHHHHHHHHHHHHCTTTCSSEEEEEEEEECTTCHHHH----HHHHHH T ss_pred CceeEEEEEEecCCCC-----------CccccHHHHHHHHHHHHHcCCCCCCCcEEEEEEecCCCChHHH----HHHHHH Confidence 4689999999997642 2456788999999999999877666889999999887664432 333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++||+.++.....++..+...++|+|++.+..+.+++...+++++++.++.... T Consensus 68 l~~------------------~~~v~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (420) T 4MQE_A 68 LLY------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLH 129 (420) T ss_dssp HHS------------------SSSCCSEEECCSHHHHHHHHHHGGGGTCEEEESSCCCGGGCCTTTCTTEEESSCCGGGH T ss_pred HHh------------------CCCeEEEEEcCchHHHHHHHHHHhhcCCEEEechhcChhhcCCCCCCceEecCCChhhc Confidence 332 14788999988777777777888899999999877665554333468899999998888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+. .+....+++++. .++|+|++.. T Consensus 130 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~d~~~~~~~~~~-~~~~~ii~~~ 202 (420) T 4MQE_A 130 NPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIVGLF 202 (420) T ss_dssp HHHHHHHHHHHTCCEEEEEEESCHHHHHHHHHHHHHHHHT-TCEEEEEEEES-----SCCHHHHHHHHH-TTCCEEEEEC T ss_pred hHHHHHHHHHhCCcEEEEEEeCCcchhhHHHHHHHHHHHC-CcEEEEEeccc-----CCCchHHHHHHh-CCCEEEEEEC Confidence 8889998888899999999977777777778888887765 45554332221 234455666663 5788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDS----WGSKIAPV-----YQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-- 350 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~----~~~~~~~~-----~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-- 350 (908) .......+++++++.|+.. .+.|+..+. |....... ........|.+...... +..... T Consensus 203 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~---------~~~~~~~~ 273 (420) T 4MQE_A 203 YETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVM---------LNPANTRS 273 (420) T ss_dssp CHHHHHHHHHHHHHTTCCSTTCEEEEESCSCTTGGGSCCTTCCSCHHHHHHHHTTCEEEEECC---------SCSSCCCC T ss_pred CHHHHHHHHHHHHHcCccCCCeEEEeecccccchhhhcCCCCCCCHHHHHHHHhcceeEEEec---------cCCCCCCc Confidence 6656778888888887643 345665431 11000000 00001122222111000 000000 Q NP_000836.2 351 ANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IG 429 (908) Q Consensus 351 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~ 429 (908) ...+....|.+.+.+.++.. +.......++..+|||++++++|++++........ .. T Consensus 274 ~~~~~~~~f~~~~~~~~~~~----------------------p~~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~ 331 (420) T 4MQE_A 274 ISNMTSQEFVEKLTKRLKRH----------------------PEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRL 331 (420) T ss_dssp TTSCCHHHHHHHHHHHCSSC----------------------TTTSTTTTTHHHHHHHHHHHHHHHHHHC--------CG T ss_pred ccCCCHHHHHHHHHHHHhcC----------------------CccCCCCcchHHHHHHHHHHHHHHHHHhccCccCCCCH Confidence 00011111222222211100 00001124567899999999999998864321100 00 Q NP_000836.2 430 LCPR-MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~-~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|.. .....+..+.+.+++..|.|.+| .+.||++|++...+.+.+++ ++.++.+|.|+.. T Consensus 332 ~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~~~f~~~g~~~~~~~v~~~~----~~~~~~v~~~~~~ 392 (420) T 4MQE_A 332 EDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDST 392 (420) T ss_dssp GGCCTTCHHHHHHHHHHHHTCCEEETTE-EECBCTTSBBCCEEEEEEEC----SSSEEEEEEEETT T ss_pred HHcCCCChHHHHHHHHHHhcCceecccc-eEEEcCCCCcceeEEEEEee----CCceEEEEEEEcC Confidence 0000 00123445667777788999988 89999999987777788876 3578899999865 No 45 >4MS4_A Gamma-aminobutyric acid type B receptor; heterodimeric protein complex, Venus Flytrap; HET: 2C0, NAG; 1.9A {Homo sapiens} Probab=99.67 E-value=2e-21 Score=212.36 Aligned_cols=376 Identities=21% Similarity=0.283 Sum_probs=233.6 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++.. ..+.....|++.|++++|+.+++++|+++++.+.|+++++..+ .+.+.+ T Consensus 3 ~~~i~Ig~i~p~~~~~-----------~~~~~~~~~~~~a~~~~n~~~~~~~g~~i~~~~~d~~~~~~~~----~~~~~~ 67 (420) T 4MS4_A 3 RRAVYIGALFPMSGGW-----------PGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQA----TKYLYE 67 (420) T ss_dssp CEEEEEEEEECSSSSC-----------CTHHHHHHHHHHHHHHHHTCTTTCTTEEEEEEEEECTTCHHHH----HHHHHH T ss_pred CceeEEEEEEecCCCC-----------CccccHHHHHHHHHHHHHcCCCCCCCcEEEEEEecCCCChHHH----HHHHHH Confidence 4689999999997642 2456788999999999999877666889999999887664432 333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++||+.++.....++..+...++|+|++.+..+.+++...+++++++.++.... T Consensus 68 l~~------------------~~~v~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (420) T 4MS4_A 68 LLY------------------NDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLH 129 (420) T ss_dssp HHS------------------SSSCCSEEECCSHHHHHHHHHHGGGGTCEEEESSCCCGGGGCTTTSTTEEESSCCGGGH T ss_pred HHh------------------CCCeEEEEEcCchHHHHHHHHHHhhcCCEEEechhcChhhcCCCCCCceEecCCChhhc Confidence 332 14788999988777777777888899999999877665554333468899999998888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.++++++++++|++|++++.++.++....+.+++.+++. ++++.....+. .+....+++++. .++|+|++.. T Consensus 130 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~-----~d~~~~~~~~~~-~~~~~ii~~~ 202 (420) T 4MS4_A 130 NPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEA-GIEITFRQSFF-----SDPAVPVKNLKR-QDARIIVGLF 202 (420) T ss_dssp HHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEES-----SCCHHHHHHHHH-TTCCEEEEEC T ss_pred hHHHHHHHHHhCCcEEEEEEeCCcchhhHHHHHHHHHHHC-CcEEEEEeccc-----CCCchHHHHHHh-CCCEEEEEEC Confidence 8889998888899999999977777777778888887765 45554332221 234455666663 5788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDS----WGSKIAPV-----YQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-- 350 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~----~~~~~~~~-----~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-- 350 (908) .......+++++++.|+.. .+.|+..+. |....... ........|.+...... +..... T Consensus 203 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~---------~~~~~~~~ 273 (420) T 4MS4_A 203 YETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVM---------LNPANTRS 273 (420) T ss_dssp CHHHHHHHHHHHHHHTCCSTTCEEEEETTSCTTGGGSCCTTCCCCHHHHHHHHTTCEEEEECC---------SCSSCCCC T ss_pred CHHHHHHHHHHHHHcCccCCCeEEEeecccccchhhhcCCCCCCCHHHHHHHHhcceeEEEec---------cCCCCCCc Confidence 6656778888888887643 345665431 11000000 00001122222111000 000000 Q NP_000836.2 351 ANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IG 429 (908) Q Consensus 351 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~ 429 (908) ...+....|.+.+.+.++.. +.......++..+|||++++++|++++........ .. T Consensus 274 ~~~~~~~~f~~~~~~~~~~~----------------------p~~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~ 331 (420) T 4MS4_A 274 ISNMTSQEFVEKLTKRLKRH----------------------PEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRL 331 (420) T ss_dssp TTSCCHHHHHHHHHHHCSSC----------------------GGGSTTTTTHHHHHHHHHHHHHHHHHHC--------CG T ss_pred ccCCCHHHHHHHHHHHHhcC----------------------CccCCCCcchHHHHHHHHHHHHHHHHHhccCccCCCCH Confidence 00011111222222211100 00001124567899999999999998864321100 00 Q NP_000836.2 430 LCPR-MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~-~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|.. .....+..+.+.+++..|.|.+| .+.||++|++...+.+.+++ ++.++.+|.|+.. T Consensus 332 ~~~~~~~~~~~~~l~~~l~~~~~~G~~G-~~~f~~~g~~~~~~~v~~~~----~~~~~~v~~~~~~ 392 (420) T 4MS4_A 332 EDFNYNNQTITDQIYRAMNSSSFEGVSG-HVVFDASGSRMAWTLIEQLQ----GGSYKKIGYYDST 392 (420) T ss_dssp GGCCTTCSHHHHHHHHHHHTCEEEETTE-EEECCTTTCSCCEEEEEEEE----TTEEEEEEEEETT T ss_pred HHcCCCChHHHHHHHHHHhcCceecccc-eEEEcCCCCcceeEEEEEee----CCceEEEEEEEcC Confidence 0000 00123445667777788999988 89999999987777788876 3578899999865 No 46 >3Q41_C Glutamate [NMDA] receptor subunit zeta-1; NTD, NMDA, GluN1, ion channel; HET: NAG; 3.4A {Rattus norvegicus} Probab=99.66 E-value=4.8e-21 Score=206.51 Aligned_cols=348 Identities=19% Similarity=0.271 Sum_probs=226.6 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI--LDTCSRDTYALEQSLTF 119 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~--~d~~~~~~~a~~~~~~~ 119 (908) ..++++||+++|.+ ....|++.|++++|++++ +.++++.. .|++.++.. .+.+. T Consensus 3 ~~~~i~Ig~i~~~~------------------~~~~~~~~a~~~~n~~~~---~~~i~l~~~~~d~~~~~~~---~~~~~ 58 (384) T 3Q41_C 3 DPKIVNIGAVLSTR------------------KHEQMFREAVNQANKRHG---SWKIQLNATSVTHKPNAIQ---MALSV 58 (384) T ss_dssp -CCCBEEEEEESSH------------------HHHHHHHHHHHTTTTTSC---TTTSCBCCEEEECCSSSSH---HHHHC T ss_pred CCceeEEEeeechH------------------HHHHHHHHHHHHHHhcCC---CcceEEEEEEecCCCCHHH---HHHHH Confidence 35789999999874 245789999999998754 34566655 776654322 12222 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-----SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSR 194 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-----~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~ 194 (908) .+.+.. +++++++|+..+ .....++.++...++|+|++.+..+.+.+...++++++ T Consensus 59 ~~~l~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~ 119 (384) T 3Q41_C 59 CEDLIS-------------------SQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLR 119 (384) T ss_dssp CCCCGG-------------------GCEEEEEECCCCSTTTTTTHHHHHHHHHTTTCCEEESSCCCGGGTCTTSCTTEEE T ss_pred HHHHHh-------------------cCceEEEEcCCCCCCCCCChhHHHHHhHhcCCCEEecccCChhHcCCcccccEee Confidence 222221 478899997665 24456677888899999998876665554434688999 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.++....+.++++++++++|+++++++.++.++....+.+++.+++. ++++.....+. ....+....+++++. .+ T Consensus 120 ~~~~~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~l~~-~~ 195 (384) T 3Q41_C 120 TVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEER-ESKAEKVLQFD--PGTKNVTALLMEARE-LE 195 (384) T ss_dssp SSCCSGGGHHHHHHHHHTTTCCCCEEEEESSHHHHHHHHHHHHHHHTS-SCCCSEEEEEC--SSCSCCHHHHHHHHT-SS T ss_pred cCCCHHHHHHHHHHHHHHcCCcEEEEEEecCcChhHHHHHHHHHHHhc-CceeEEEEeeC--CCChhHHHHHHHHHh-CC Confidence 999998889999999988899999999987777777777888777765 35554332222 122345566777763 57 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) +++|++.........+++++++.|+.. ++.|+..+.|..... ......+.+. T Consensus 196 ~~~ii~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~----~~~~~~~~~~----------------------- 248 (384) T 3Q41_C 196 ARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNA----LRYAPDGIIG----------------------- 248 (384) T ss_dssp CCEEEEECCHHHHHHHHHHHHTTTCSSTTCEEEECSSTTSTHH----HHHCCTTCEE----------------------- T ss_pred CeEEEEECCHHHHHHHHHHHHHcCCcCCCeEEEEecccCCcch----HhhCCCcEEE----------------------- Confidence 888888777777788888888888753 456766543321100 0000000000 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG-YIGLCP 432 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~-~~~~~~ 432 (908) + . . ..+..++..+|||++++++|++++....+.. ....|. T Consensus 249 -----~----~-~-----------------------------~~~~~~~~~~yDa~~~~~~al~~~~~~~~~~~~~~~c~ 289 (384) T 3Q41_C 249 -----L----Q-L-----------------------------INGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCV 289 (384) T ss_dssp -----E----E-E-----------------------------TTTTCHHHHHHHHHHHHHHHHHHHTTSSSCCCCCSCCT T ss_pred -----E----E-e-----------------------------cCCCcchhHHHHHHHHHHHHHHHHHHccCCCCCCCCcc Confidence 0 0 0 0112456789999999999999887543211 011222 Q NP_000836.2 433 RM--STIDGKELLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLH-LKVEDMQWAHR 507 (908) Q Consensus 433 ~~--~~~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~-~~~~~i~w~~~ 507 (908) .. ....+..+.+.|++ ..|.|.+| .+.||++|++. ..+.+++++ ++.++.||.|+.... +....+.|.++ T Consensus 290 ~~~~~~~~~~~l~~~l~~~~~~~g~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~vg~~~~~~~~~~~~~~~w~~~ 364 (384) T 3Q41_C 290 GNTNIWKTGPLFKRVLMSSKYADGVTG-RVEFNEDGDRKFANYSIMNLQ----NRKLVQVGIYNGTHVIPNDRKIIWPGG 364 (384) T ss_dssp TCCCCCTHHHHHHHHHHSCEECSCSSS-CEECCSSSCCCCCCEEEEEEE----TTEEEEEEEEETTEEEECSSCCCBTTT T ss_pred CCCchhccHHHHHHHHhcCCcccCCCc-cEEECCCCCccceEEEEEEee----CCcEEEEEEEeCCCcccCCCCccCCCC Confidence 11 11234456677765 46899988 89999999985 788888887 357899999986531 22235778653 No 47 >5KC8_A Glutamate receptor ionotropic, delta-2; ionotropic glutamate receptor (iGluR), neurotransmission; HET: EDO; 1.751A {Homo sapiens} Probab=99.64 E-value=9.9e-21 Score=207.43 Aligned_cols=378 Identities=16% Similarity=0.219 Sum_probs=229.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~ 120 (908) .+++++||+++|.++. ....|+++|++++|+++++++|.++++.+.| +++++..+.+. + T Consensus 3 ~~~~i~Ig~i~p~sg~----------------~~~~a~~~A~~~in~~~~~~~~~~i~~~~~d~~~~~~~~~~~~----~ 62 (429) T 5KC8_A 3 GDSIIHIGAIFDESAK----------------KDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQE----A 62 (429) T ss_dssp -CCCEEEEEEEETTCH----------------HHHHHHHHHHHHHHHCTTSSTTCCEEEEEEEECTTCHHHHHHH----H T ss_pred CCceeeeEEEeeCCCh----------------hHHHHHHHHHHHHHhCCCccCCCeEEEEEEecCCCCHHHHHHH----H Confidence 4578999999998752 4668999999999998777778899999888 66654433332 3 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELS--------DNTRYDFF 192 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~--------~~~~~~~~ 192 (908) .+++. ++++++||+.++..+..++.++...+||+|++.+.++.+. ....++++ T Consensus 63 ~~l~~-------------------~~v~avig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 123 (429) T 5KC8_A 63 CELMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 123 (429) T ss_dssp HHHHH-------------------HCCSCEEEEECHHHHHHHHHHHHHHTCCEEEEECCSTTCCCCCCCCCCCCSSCCCE T ss_pred HHHHh-------------------cCceEEEcCCChHHHHHHHHHHHhcCCCEEEeecCCCCCCCCcCCccccCCCCcce Confidence 33322 4788999998887777788888999999999877654211 11246889 Q NP_000836.2 193 SRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIP------REPRPGEFEKII 266 (908) Q Consensus 193 ~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~------~~~~~~~~~~~~ 266 (908) +++.|+. .+++++++++++++|++|++++.+ +++....+.+.+.+++. ++++......+ ......++...+ T Consensus 124 ~~~~p~~-~~~~a~~~~l~~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~l 200 (429) T 5KC8_A 124 LSVRPPV-YLHDVILRVVTEYAWQKFIIFYDS-EYDIRGIQEFLDKVSQQ-GMDVALQKVENNINKMITTLFDTMRIEEL 200 (429) T ss_dssp EECSCCC-CHHHHHHHHHHHTTCCEEEEEECT-TCCGGGGHHHHHHHHHT-TCEEEEEECCSCHHHHHHHHHHHCCHHHH T ss_pred eecCCCh-hHHHHHHHHHHHcCCCEEEEEeCC-hHHHHHHHHHHHHHHhc-CceEEEEeecccccccchhhhhhhHHHHH Confidence 9999987 788899999988999999999975 67777777788777665 35554321110 001123455666 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .+ +.|++......+..+++++++.|+.. .+.|+..+.+...............+...+.... T Consensus 201 ~~~~~-~~-~~vv~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---------- 268 (429) T 5KC8_A 201 NRYRD-TL-RRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTF---------- 268 (429) T ss_dssp HHHHH-HT-TEEEEESCHHHHHHHHHHHHHTTSSCTTCEEEEECSCCCHHHHHHHHHHCCSEEEEEEEEC---------- T ss_pred HHHhh-cC-CEEEEEcCHHHHHHHHHHHHHcCCCcCCeEEEEecCCccccchHHHHHHHhcceEEEEeec---------- Confidence 66653 34 44445555667788999999888764 4567766533221110000000111111111000 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) .. .......+|.+.+++.+.. |...... ...+..++..+|||++++++|++++....+. T Consensus 269 ~~---~~~~~~~~f~~~~~~~~~~--------------~~~~~~~----~~~~~~~~~~~yDav~~~~~al~~~~~~~~~ 327 (429) T 5KC8_A 269 PV---PQNISQRCFRGNHRISSTL--------------CDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLEDRKW 327 (429) T ss_dssp CC---CCSHHHHSEETTEECCHHH--------------HCTTSHH----HHTCCHHHHHHHHHHHHHHHHHHHHHHTTCC T ss_pred CC---ChhhchhhHhhcccccccC--------------CCCCCcc----ccccChHHHHHHHHHHHHHHHHHHHHHcccc Confidence 00 0000111122222222110 0000000 0123456788999999999999988754321 Q NP_000836.2 426 G--YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTNQL 495 (908) Q Consensus 426 ~--~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~~~ 495 (908) . ....|... ...++..+.+.|++..|.|.+| ++.|+++|++. ..+.|++++... .++.++.||.|+... T Consensus 328 ~~~~~~~c~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~i~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~vg~w~~~~ 403 (429) T 5KC8_A 328 HSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTG-ELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVT 403 (429) T ss_dssp CCCCCCCSSSTTCCCCTTHHHHHHHHHTCEEEETTE-EEECCTTSBCCCCEEEEEEC--------CCEEEEEEETTT T ss_pred cCCCCCccccccCCccccHHHHHHHHHhCceeecce-eEEeCCCCCcCcceEEEEeeecccccCCCeEEEEEEeCCC Confidence 0 01122211 0114556778888889999999 89999999886 577888887310 124689999998753 No 48 >3OM0_A Glutamate receptor, ionotropic kainate 5; Membrane Protein, Ion channel; HET: BMA, GOL, NAG; 1.401A {Rattus norvegicus} Probab=99.62 E-value=2.1e-20 Score=201.91 Aligned_cols=370 Identities=15% Similarity=0.164 Sum_probs=229.1 Template_Neff=12.200 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++. .+.....|+++|++++|+++++++|+++++++.|++++... .+.+.+++ T Consensus 2 ~~~i~ig~~~~~~~~-------------~g~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~---~~~~~~~~ 65 (393) T 3OM0_A 2 LSSLRMAAILDDQTV-------------CGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQY---ETTDTMCQ 65 (393) T ss_dssp CCEEEEEEEECCCCS-------------SCCCHHHHHHHHHHHHHHSCCSSCCCEEEEEEEECCSSCHH---HHHHHHHH T ss_pred CccceeeeeecCCCC-------------CcHHHHHHHHHHHHHHHccCCCCCCCEEEEEEEEcCCCChH---HHHHHHHH Confidence 468999999998763 45678899999999999988777788999999887654321 12222333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. ++++++||+.++. ....++.++...++|+|++.+.++.+... .+++++++.|++.. T Consensus 66 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~ 125 (393) T 3OM0_A 66 ILP-------------------KGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQY-LRFASVSLYPSNED 125 (393) T ss_dssp HGG-------------------GCCSCEECCSSCHHHHHHHHHHHHHHTCCEEECSCCCCC-----CCSCCEESSCCHHH T ss_pred hcc-------------------cCceEEECCCCCHHhHHHHHHHHhhcCCCEEEecCCCCccccc-ceeeEEEcCCCHHH Confidence 322 5789999998875 56777888899999999988765544322 35678899999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+.++++++++++|+++++++.+++++....+ +.+.+++. +..+ ....+. ...++...+++++. .++++|++. T Consensus 126 ~~~~l~~~l~~~~~~~v~ii~~~~~~~~~~~~-~~~~~~~~-~~~~-~~~~~~---~~~~~~~~~~~l~~-~~~~~i~~~ 198 (393) T 3OM0_A 126 VSLAVSRILKSFNYPSASLICAKAECLLRLEE-LVRGFLIS-KETL-SVRMLD---DSRDPTPLLKEIRD-DKVSTIIID 198 (393) T ss_dssp HHHHHHHHHHHTTSCCEEEEESSTTHHHHTHH-HHHHHHHS-SSCE-EEEECC----CCCSHHHHHHHHH-HTCSEEEEE T ss_pred HHHHHHHHHHHcCCCeEEEEEechhHHHHHHH-HHHhhccC-CCee-EEEecC---CCCCcHHHHHHHhc-CCCcEEEEE Confidence 89999999988899999999977766654444 44444432 2111 111111 22345566777763 578999888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|. T Consensus 199 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~ 262 (393) T 3OM0_A 199 ANASISHLVLRKASELGMTSAFYKYILTTMDFPILHL-DGIVEDSSNILGFSMF-----------N----TSHPFYPEFV 262 (393) T ss_dssp SCHHHHHHHHHHHHHTTTTSTTCEEEECCTTGGGCCC-TTTCCSSCSEEEEECC-----------C----TTSTTHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCCCCceEEEcCCCcccCCH-HHhcccCceEEEEEEe-----------c----CCCccHHHHH Confidence 77777888999998888753 3456654321111000 0001111111111100 0 0011111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG-YIGLCPRMS-TID 438 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~-~~~~~~~~~-~~~ 438 (908) +.+.+.+.. .|... ....+..++..+|||+++++++++++....+.. ....|.... ..+ T Consensus 263 ~~~~~~~~~-------------~~~~~------~~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~~~~~~c~~~~~~~~ 323 (393) T 3OM0_A 263 RSLNMSWRE-------------NCEAS------TYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPH 323 (393) T ss_dssp HHHHHHHTT-------------TSCGG------GCCSCCHHHHHHHHHHHHHHHHHHHHTTTSCCCCCCCCTTCCCCCTT T ss_pred HHHHHhchh-------------ccccC------CCCCCChhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCCcccchh Confidence 222222211 01000 001234567789999999999999986532110 112232111 124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ .+.+..||.|.... T Consensus 324 ~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 376 (393) T 3OM0_A 324 GTSLMNYLRMVEYDGLTG-RVEFNSKGQRTNYTLRILEKS----RQGHREIGVWYSNR 376 (393) T ss_dssp HHHHHHHHTTCCEEETTE-EECBCTTSCBCSCEEEEEEEE----TTEEEEEEEEECC- T ss_pred HHHHHHHHhcCccccccc-eeeeCCCCCcCceEEEEEEec----ccceEEEEEEecCC Confidence 556778888889999988 899999998875 77787776 25688999998764 No 49 >3QLU_B Glutamate receptor, ionotropic kainate 5; Membrane protein, Glycosylation; HET: NAG, GOL; 2.906A {Rattus norvegicus} Probab=99.62 E-value=2.1e-20 Score=201.91 Aligned_cols=370 Identities=15% Similarity=0.164 Sum_probs=231.0 Template_Neff=12.200 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++. .+.....|+++|++++|+++++++|+++++++.|++++... .+.+.+++ T Consensus 2 ~~~i~ig~~~~~~~~-------------~g~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~---~~~~~~~~ 65 (393) T 3QLU_B 2 LSSLRMAAILDDQTV-------------CGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQY---ETTDTMCQ 65 (393) T ss_dssp CCCEEEEEEECCCSS-------------SCCSHHHHHHHHHHHHHHSCCSSCCCCEEEEEEECSSSCHH---HHHHHHHH T ss_pred CccceeeeeecCCCC-------------CcHHHHHHHHHHHHHHHccCCCCCCCEEEEEEEEcCCCChH---HHHHHHHH Confidence 468999999998763 45678899999999999988777788999999887654321 12222333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. ++++++||+.++. ....++.++...++|+|++.+.++.+... .+++++++.|++.. T Consensus 66 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~ 125 (393) T 3QLU_B 66 ILP-------------------KGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQY-LRFASVSLYPSNED 125 (393) T ss_dssp HGG-------------------GCCSCEECCSSCHHHHHHHHHHHHHHTCCEEECSCCSCCCCTT-SCCCEEESSCCHHH T ss_pred hcc-------------------cCceEEECCCCCHHhHHHHHHHHhhcCCCEEEecCCCCccccc-ceeeEEEcCCCHHH Confidence 322 5789999998875 56777888899999999988765544322 35678899999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+.++++++++++|+++++++.+++++....+ +.+.+++. +..+ ....+. ...++...+++++. .++++|++. T Consensus 126 ~~~~l~~~l~~~~~~~v~ii~~~~~~~~~~~~-~~~~~~~~-~~~~-~~~~~~---~~~~~~~~~~~l~~-~~~~~i~~~ 198 (393) T 3QLU_B 126 VSLAVSRILKSFNYPSASLICAKAECLLRLEE-LVRGFLIS-KETL-SVRMLD---DSRDPTPLLKEIRD-DKVSTIIID 198 (393) T ss_dssp HHHHHHHHHHHTTSCCEEEEESSTTHHHHTHH-HHTTSCBB-TTTE-EEEECC---SSCCCHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCeEEEEEechhHHHHHHH-HHHhhccC-CCee-EEEecC---CCCCcHHHHHHHhc-CCCcEEEEE Confidence 89999999988899999999977766654444 44444432 2111 111111 22345566777763 578999888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|. T Consensus 199 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~ 262 (393) T 3QLU_B 199 ANASISHLVLRKASELGMTSAFYKYILTTMDFPILHL-DGIVEDSSNILGFSMF-----------N----TSHPFYPEFV 262 (393) T ss_dssp SCHHHHHHHHHHHHHTTTTSSSCEEEECCSCCTTCCC-TTTCCSSCEEEEEECC-----------C----TTSTTHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCCCCceEEEcCCCcccCCH-HHhcccCceEEEEEEe-----------c----CCCccHHHHH Confidence 77777888999998888753 3456654321111000 0001111111111100 0 0011111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG-YIGLCPRMS-TID 438 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~-~~~~~~~~~-~~~ 438 (908) +.+.+.+.. .|... ....+..++..+|||+++++++++++....+.. ....|.... ..+ T Consensus 263 ~~~~~~~~~-------------~~~~~------~~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~~~~~~c~~~~~~~~ 323 (393) T 3QLU_B 263 RSLNMSWRE-------------NCEAS------TYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPH 323 (393) T ss_dssp HHHHHHHHH-------------HCSSS------CCCCCCHHHHHHHHHHHHHHHHHHHHHTTSCCCCCCCCTTSCCCCTT T ss_pred HHHHHhchh-------------ccccC------CCCCCChhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCCcccchh Confidence 222222211 01000 001234567789999999999999986532110 112232111 124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ .+.+..||.|.... T Consensus 324 ~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 376 (393) T 3QLU_B 324 GTSLMNYLRMVEYDGLTG-RVEFNSKGQRTNYTLRILEKS----RQGHREIGVWYSNR 376 (393) T ss_dssp HHHHHHHHHTCCEEETTE-EECBCTTSCBCSCEEEEEECC----SSSCCEEEEEESSS T ss_pred HHHHHHHHhcCccccccc-eeeeCCCCCcCceEEEEEEec----ccceEEEEEEecCC Confidence 556778888889999988 899999998875 77787776 25688999998764 No 50 >5FWY_B GLUTAMATE RECEPTOR 2, GLUTAMATE RECEPTOR; TRANSPORT PROTEIN; HET: SO4, NAG; 2.12A {RATTUS NORVEGICUS} Probab=99.62 E-value=2.4e-20 Score=201.38 Aligned_cols=372 Identities=13% Similarity=0.153 Sum_probs=227.7 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDL-LSNITLGVRILD-TCSRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~i-l~g~~l~~~~~d-~~~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. ....|++.|++++|+++++ ++|+++++++.| +.+++.. ..+.+ T Consensus 3 ~~~i~Ig~~~~~~~~----------------~~~~~~~~a~~~~n~~g~~~~~g~~l~~~~~d~~~~~~~~----~~~~~ 62 (390) T 5FWY_B 3 PNTISIGGLFMRNTV----------------QEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFS----VTNAF 62 (390) T ss_dssp CSEEEEEEEECTTCH----------------HHHHHHHHHHHHHHTCCCTTTCSSEEEEEEEECSSCCHHH----HHHHH T ss_pred CceeEEEEeecCCCH----------------HHHHHHHHHHHHHHcCCCCCCCCceEEEEEEecCCCChHH----HHHHH Confidence 568999999998752 4668999999999998765 357888888876 4444332 22233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. +++++++|+.++..+..++..+...++|+|++..... ..+++++++.|+ T Consensus 63 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~p~-- 116 (390) T 5FWY_B 63 CSQFS-------------------RGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTD-----ADVQFVIQMRPA-- 116 (390) T ss_dssp HHHHH-------------------HCCSCEEECCCTTTHHHHHHHHHHHTCCEEECSCCCS-----SCCSSEEECSCC-- T ss_pred HHHhh-------------------CCeeEEEcCCCchhHHHHHHHHHhcCCceeeCCCCCC-----CCCCcEEEeecc-- Confidence 33322 5788999998887777788888999999998775432 246788998887 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +++++++++++++|+++++++++ .++....+.+++.+++. ++++......+. .+..++...+++++. .++++|++ T Consensus 117 -~~~~~~~~~~~~~~~~v~vl~~~-~~~~~~~~~~~~~~~~~-~~~v~~~~~~~~-~~~~~~~~~~~~l~~-~~~~~vv~ 191 (390) T 5FWY_B 117 -LKGAILSLLSYYKWEKFVYLYDT-ERGFSVLQAIMEAAVQN-NWQVTARSVGNI-KDVQEFRRIIEEMDR-RQEKRYLI 191 (390) T ss_dssp -CHHHHHHHHHHTTCCEEEEEECS-TTCSHHHHHHHHHHHHH-TCEEEEEECTTC-CSHHHHHHHHHHHHH-TTCCEEEE T ss_pred -HHHHHHHHHHHcCCcEEEEEEeC-cccHHHHHHHHHHHHhC-CCeEEEEEeCCC-CCHHHHHHHHHHHhh-cCCcEEEE Confidence 46788888888899999999954 67777777777777664 345433211110 122456667777763 57898888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|+..+.+...... ........+...+.... ...+....| T Consensus 192 ~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~---------------~~~~~~~~f 255 (390) T 5FWY_B 192 DCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILL-ERVMHGGANITGFQIVN---------------NENPMVQQF 255 (390) T ss_dssp ESCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGSCC-HHHHHHTCEEEEEESCC---------------TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCccCCeeEEEecCCcchhcH-HHHhcCCccEEEEEEec---------------CCCHHHHHH Confidence 776677788899998888753 3556665433221100 00001111111111000 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.+...... .+ ...+..++..+||+++++++|++++...... .....|... T Consensus 256 ~~~~~~~~~~~~~~---------~~----------~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 316 (390) T 5FWY_B 256 IQRWVRLDEREFPE---------AK----------NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANP 316 (390) T ss_dssp HHHHTTSCTTTSTT---------CT----------TSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCSSSCCSCTTCSS T ss_pred HHHHHhcCcccCCC---------CC----------CCCCChHHHHHHHHHHHHHHHHHHHHHcCCCcccCCCCCcccCCC Confidence 23232222110000 00 0123456778999999999999988653210 001122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.+.|++..|.|.+| ++.||++|++. ..+.+++++. +.++.+|.|.....++.....|+ T Consensus 317 ~~~~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~vg~w~~~~~~~~~~~~~~ 385 (390) T 5FWY_B 317 AVPWSQGIDIERALKMVQVQGMTG-NIQFDTYGRRTNYTIDVYEMKV----SGSRKAGYWNEYERFVPFSGTKH 385 (390) T ss_dssp CCCCTTHHHHHHHHHTCCEEETTE-EEEECTTSCEESCCEEEEEEC------CEEEEEEEETTTEEEECCC--- T ss_pred CCcchhHHHHHHHHhcCCccCCCc-eEEECCCCceeeeEEEEEEeee----cCcEEEEEEcCCCccccCCCCCC Confidence 0114556778888889999998 89999988886 4778888762 46889999987654444445564 No 51 >6FPJ_A Glutamate receptor 3; ligand-gated ion channel, membrane protein; HET: DMS, NAG, PO4; 1.96A {Rattus norvegicus} Probab=99.62 E-value=2.4e-20 Score=201.38 Aligned_cols=372 Identities=13% Similarity=0.153 Sum_probs=227.2 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDL-LSNITLGVRILD-TCSRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~i-l~g~~l~~~~~d-~~~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. ....|++.|++++|+++++ ++|+++++++.| +.+++.. ..+.+ T Consensus 3 ~~~i~Ig~~~~~~~~----------------~~~~~~~~a~~~~n~~g~~~~~g~~l~~~~~d~~~~~~~~----~~~~~ 62 (390) T 6FPJ_A 3 PNTISIGGLFMRNTV----------------QEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFS----VTNAF 62 (390) T ss_dssp CSEEEEEEEEETTCH----------------HHHHHHHHHHHHHHTCCCTTTCSSEEEEEEEEESCSSHHH----HHHHH T ss_pred CceeEEEEeecCCCH----------------HHHHHHHHHHHHHHcCCCCCCCCceEEEEEEecCCCChHH----HHHHH Confidence 568999999998752 4668999999999998765 357888888876 4444332 22233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. +++++++|+.++..+..++..+...++|+|++..... ..+++++++.|+ T Consensus 63 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~p~-- 116 (390) T 6FPJ_A 63 CSQFS-------------------RGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTD-----ADVQFVIQMRPA-- 116 (390) T ss_dssp HHHHH-------------------HCCSCEEECCCTTTHHHHHHHHHHTTCCEEECSCCCS-----SCCSSEEECSCC-- T ss_pred HHHhh-------------------CCeeEEEcCCCchhHHHHHHHHHhcCCceeeCCCCCC-----CCCCcEEEeecc-- Confidence 33322 5788999998887777788888999999998775432 246788998887 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +++++++++++++|+++++++++ .++....+.+++.+++. ++++......+. .+..++...+++++. .++++|++ T Consensus 117 -~~~~~~~~~~~~~~~~v~vl~~~-~~~~~~~~~~~~~~~~~-~~~v~~~~~~~~-~~~~~~~~~~~~l~~-~~~~~vv~ 191 (390) T 6FPJ_A 117 -LKGAILSLLSYYKWEKFVYLYDT-ERGFSVLQAIMEAAVQN-NWQVTARSVGNI-KDVQEFRRIIEEMDR-RQEKRYLI 191 (390) T ss_dssp -CHHHHHHHHHHTTCCEEEEEECS-TTCSHHHHHHHHHHHHH-TCEEEEEECTTC-CSHHHHHHHHHHHHH-TTCCEEEE T ss_pred -HHHHHHHHHHHcCCcEEEEEEeC-cccHHHHHHHHHHHHhC-CCeEEEEEeCCC-CCHHHHHHHHHHHhh-cCCcEEEE Confidence 46788888888899999999954 67777777777777664 345433211110 122456667777763 57898888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|+..+.+...... ........+...+.... ...+....| T Consensus 192 ~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~---------------~~~~~~~~f 255 (390) T 6FPJ_A 192 DCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILL-ERVMHGGANITGFQIVN---------------NENPMVQQF 255 (390) T ss_dssp ESCHHHHHHHHHHHHHHCSSSTTCEEEECCTTGGGCCC-HHHHHTTCEEEEEESCC---------------TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCccCCeeEEEecCCcchhcH-HHHhcCCccEEEEEEec---------------CCCHHHHHH Confidence 776677788899998888753 3556665433221100 00001111111111000 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.+...... .+ ...+..++..+||+++++++|++++...... .....|... T Consensus 256 ~~~~~~~~~~~~~~---------~~----------~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 316 (390) T 6FPJ_A 256 IQRWVRLDEREFPE---------AK----------NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANP 316 (390) T ss_dssp HHHHTTSCTTTSTT---------SS----------SSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCC-----CCC-- T ss_pred HHHHHhcCcccCCC---------CC----------CCCCChHHHHHHHHHHHHHHHHHHHHHcCCCcccCCCCCcccCCC Confidence 23232222110000 00 0123456778999999999999988653210 001122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.+.|++..|.|.+| ++.||++|++. ..+.+++++. +.++.+|.|.....++.....|+ T Consensus 317 ~~~~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~vg~w~~~~~~~~~~~~~~ 385 (390) T 6FPJ_A 317 AVPWSQGIDIERALKMVQVQGMTG-NIQFDTYGRRTNYTIDVYEMKV----SGSRKAGYWNEYERFVPFSGTKH 385 (390) T ss_dssp CCCCTTHHHHHHHHHTCCEEETTE-EEEECTTSBEESCCEEEEEEET----TEEEEEEEEETTTEEEECC---- T ss_pred CCcchhHHHHHHHHhcCCccCCCc-eEEECCCCceeeeEEEEEEeee----cCcEEEEEEcCCCccccCCCCCC Confidence 0114556778888889999998 89999988886 4778888762 46889999987654444445564 No 52 >3H5L_A putative Branched-chain amino acid ABC; STRUCTURAL GENOMICS, TRANSPORTER, PSI-2, Protein; 1.7A {Ruegeria pomeroyi} Probab=99.61 E-value=2.8e-20 Score=202.99 Aligned_cols=363 Identities=13% Similarity=0.140 Sum_probs=230.2 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD-TYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~-~~a~~~~~~ 118 (908) ....++++||++.|.++... ..+.....|++.|++++|+++++. |+++++.+.|+++++ .. +.+ T Consensus 9 ~~~~~~i~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~~----~~~ 73 (419) T 3H5L_A 9 AQSSDPVVIGCPAPLTGIVA----------ADGIEFQRGIQMAADEINAVGGIL-GRPIELVFADTQSKGVDV----VIQ 73 (419) T ss_dssp ----CCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHTTTSBT-TBCEEEEEEECTTCCHHH----HHH T ss_pred cCCCCCEEEEEeecCCCCch----------hccHHHHHHHHHHHHHHHHcCCcC-CcceEEEEEeCCCCCHHH----HHH Confidence 45678999999999876431 245678899999999999987654 788999888877653 22 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA--PELS--DNTRYDFFSR 194 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~--~~l~--~~~~~~~~~~ 194 (908) .+++++. .++++++||+.++.....++..+.+.++|+|++.... +.+. +...++++++ T Consensus 74 ~~~~l~~------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 135 (419) T 3H5L_A 74 SAQRLID------------------RDNASALIAGYNLENGTALHDVAADAGVIAMHANTVAVHDEMVKSDPDRYWGTFQ 135 (419) T ss_dssp HHHHHHH------------------TTCCSEEECSCCSSCSCHHHHHHHHHTCEEEECCCCHHHHHHHHHCTTTCTTEEE T ss_pred HHHHHHH------------------hcCCCEEEecccccchHHHHHHHHHcCCcEEeCCCchhcHHHHhcCccccCceee Confidence 3343332 1578999999888777788888899999999876422 2222 1123567889 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTA--------LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~--------~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) +.++....+.++++++.+ .+|+++++++.++.++....+.+++.+++. ++++.....+. ....++...+ T Consensus 136 ~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~ 212 (419) T 3H5L_A 136 YDPPETLYGGGFLKFLKDIEDNGEFSRPNNKIAIITGPGIYSVNIANAIRDGAGEY-GYDVSLFETVA--IPVSDWGPTL 212 (419) T ss_dssp SSCCTHHHHHHHHHHHHHHHHTTSCCCSSSEEEEEECSSHHHHHHHHHHHHHGGGG-TCEEEEEEECC--SSCSCCHHHH T ss_pred cCCChhHhHHHHHHHHHHHHhCCCCCCCCCeEEEEECCCHHHHHHHHHHHHHHHHc-CCEEEEEEeeC--CCCCCcHHHH Confidence 999888888888888866 689999999977777888888888888765 45554332222 2234566677 Q NP_000836.2 267 KRLLETPNARAVIMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++.+ .+..+..+++++++.|+.. .|++...+...... ........+.+.... + T Consensus 213 ~~i~~-~~~~vv~~~~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~-~~~~~~~~g~~~~~~-----------~ 277 (419) T 3H5L_A 213 AKLRA-DPPAVIVVTHFYPQDQALFMNQFMTDPTNS--LVYLQYGASLAAFR-DIAGDNSVGVTYATV-----------L 277 (419) T ss_dssp HHHHH-SCCSEEEECCCCHHHHHHHHHHHTTSCCSC--EEEECSGGGSHHHH-HHHGGGGTTCEEEES-----------S T ss_pred HHHHh-CCCCEEEEEeCChHHHHHHHHHHhhCCcCc--EEEEechhhhHHHH-HHHcccceeeEEEec-----------c Confidence 77764 5788888775 4566778889988887742 34443322211100 000111222211110 0 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) . ....+....|.+.+++.++. .....++..+|||+++++.+++....... T Consensus 278 ~---~~~~~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~- 327 (419) T 3H5L_A 278 G---TLQDEMGDAFAKAYKERYGD--------------------------LSSTASGCQTYSALYAYSIAAALAGGPGA- 327 (419) T ss_dssp C---CCSSHHHHHHHHHHHHHHCT--------------------------TSCHHHHHHHHHHHHHHHHHHHHTTSCCC- T ss_pred C---cCCCHHHHHHHHHHHHHHCC--------------------------CCCCcCcchHHHHHHHHHHHHHHcCCCCC- Confidence 0 00011122233333322211 01123466799999999999876543210 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) + ....++..+.++|++..|.|.+| ++.||++|++...+.+..++.. ...+..|+.|.. T Consensus 328 -----~--~~~~~~~~l~~~l~~~~f~g~~G-~v~f~~~g~~~~~~~~~~~~~~--~~~~~~v~q~~~ 385 (419) T 3H5L_A 328 -----P--YDDVQNKAVADRLRSLIFRGPVG-TMRFHADTQSAWSYPTETNDPS--LGMPHIFSQIFD 385 (419) T ss_dssp -----T--TCHHHHHHHHHHHHHCEEEETTE-EEEBCTTTCBBCEETTTCSCTT--SSEECEEEECCC T ss_pred -----C--CCcccHHHHHHHHHhCCcccCCe-eEEeCCCCcccCCCCCcCCCcc--cccceEEEEeec Confidence 0 01234567888899889999999 8999999988777777776632 245778888886 No 53 >3H5L_B putative Branched-chain amino acid ABC; STRUCTURAL GENOMICS, TRANSPORTER, PSI-2, Protein; 1.7A {Ruegeria pomeroyi} Probab=99.61 E-value=2.8e-20 Score=202.99 Aligned_cols=363 Identities=13% Similarity=0.140 Sum_probs=232.5 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRD-TYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~-~~a~~~~~~ 118 (908) ....++++||++.|.++... ..+.....|++.|++++|+++++. |+++++.+.|+++++ .. +.+ T Consensus 9 ~~~~~~i~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~~----~~~ 73 (419) T 3H5L_B 9 AQSSDPVVIGCPAPLTGIVA----------ADGIEFQRGIQMAADEINAVGGIL-GRPIELVFADTQSKGVDV----VIQ 73 (419) T ss_dssp CCCSSCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCCHHH----HHH T ss_pred cCCCCCEEEEEeecCCCCch----------hccHHHHHHHHHHHHHHHHcCCcC-CcceEEEEEeCCCCCHHH----HHH Confidence 45678999999999876431 245678899999999999987654 788999888877653 22 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA--PELS--DNTRYDFFSR 194 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~--~~l~--~~~~~~~~~~ 194 (908) .+++++. .++++++||+.++.....++..+.+.++|+|++.... +.+. +...++++++ T Consensus 74 ~~~~l~~------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 135 (419) T 3H5L_B 74 SAQRLID------------------RDNASALIAGYNLENGTALHDVAADAGVIAMHANTVAVHDEMVKSDPDRYWGTFQ 135 (419) T ss_dssp HHHHHHH------------------TTCCSEEECSCCSSCSCHHHHHHHHHTCEEEECCCCHHHHHHHHHCTTTCTTEEE T ss_pred HHHHHHH------------------hcCCCEEEecccccchHHHHHHHHHcCCcEEeCCCchhcHHHHhcCccccCceee Confidence 3343332 1578999999888777788888899999999876422 2222 1123567889 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTA--------LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~--------~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~ 266 (908) +.++....+.++++++.+ .+|+++++++.++.++....+.+++.+++. ++++.....+. ....++...+ T Consensus 136 ~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~ 212 (419) T 3H5L_B 136 YDPPETLYGGGFLKFLKDIEDNGEFSRPNNKIAIITGPGIYSVNIANAIRDGAGEY-GYDVSLFETVA--IPVSDWGPTL 212 (419) T ss_dssp SSCCTHHHHHHHHHHHHHHHHTTSCCCSSSEEEEEECSSHHHHHHHHHHHHHGGGG-TCEEEEEEECC--SSCSCCHHHH T ss_pred cCCChhHhHHHHHHHHHHHHhCCCCCCCCCeEEEEECCCHHHHHHHHHHHHHHHHc-CCEEEEEEeeC--CCCCCcHHHH Confidence 999888888888888866 689999999977777888888888888765 45554332222 2234566677 Q NP_000836.2 267 KRLLETPNARAVIMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) ++++. .++++|++.+ .+..+..+++++++.|+.. .|++...+...... ........+.+.... + T Consensus 213 ~~i~~-~~~~vv~~~~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~-~~~~~~~~g~~~~~~-----------~ 277 (419) T 3H5L_B 213 AKLRA-DPPAVIVVTHFYPQDQALFMNQFMTDPTNS--LVYLQYGASLAAFR-DIAGDNSVGVTYATV-----------L 277 (419) T ss_dssp HHHHH-SCCSEEEECCCCHHHHHHHHHHHTTSCCSC--EEEECSGGGSHHHH-HHHGGGGTTCEEEES-----------S T ss_pred HHHHh-CCCCEEEEEeCChHHHHHHHHHHhhCCcCc--EEEEechhhhHHHH-HHHcccceeeEEEec-----------c Confidence 77764 5788888775 4566778889988887742 34443322211100 000111222211110 0 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) . ....+....|.+.+++.++. .....++..+|||+++++.+++....... T Consensus 278 ~---~~~~~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~- 327 (419) T 3H5L_B 278 G---TLQDEMGDAFAKAYKERYGD--------------------------LSSTASGCQTYSALYAYSIAAALAGGPGA- 327 (419) T ss_dssp C---CCSSHHHHHHHHHHHHHHCT--------------------------TSCHHHHHHHHHHHHHHHHHHHHTTSCCC- T ss_pred C---cCCCHHHHHHHHHHHHHHCC--------------------------CCCCcCcchHHHHHHHHHHHHHHcCCCCC- Confidence 0 00011122233333322211 01123466799999999999876543210 Q NP_000836.2 426 GYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 426 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) + ....++..+.++|++..|.|.+| ++.||++|++...+.+..++.. ...+..|+.|.. T Consensus 328 -----~--~~~~~~~~l~~~l~~~~f~g~~G-~v~f~~~g~~~~~~~~~~~~~~--~~~~~~v~q~~~ 385 (419) T 3H5L_B 328 -----P--YDDVQNKAVADRLRSLIFRGPVG-TMRFHADTQSAWSYPTETNDPS--LGMPHIFSQIFD 385 (419) T ss_dssp -----T--TCHHHHHHHHHHHHHCEEEETTE-EEEBCTTTCBBCEETTTCSCTT--SSEECEEEECSC T ss_pred -----C--CCcccHHHHHHHHHhCCcccCCe-eEEeCCCCcccCCCCCcCCCcc--cccceEEEEeec Confidence 0 01234567888899889999999 8999999988777777776632 245778888886 No 54 >5KCA_A Cerebellin-1,Cerebellin-1,Cerebellin-1,Glutamate receptor ionotropic, delta-2; Cerebellin, ionotropic glutamate receptor (iGluR); 3.1A {Homo sapiens} Probab=99.60 E-value=4.6e-20 Score=221.09 Aligned_cols=382 Identities=16% Similarity=0.223 Sum_probs=236.7 Template_Neff=10.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~ 118 (908) .....+++||+++|.++ .....|+++|++++|+++++++++++++++ .|++.++..+.+ T Consensus 452 ~~~~~~i~IG~i~~~sg----------------~~~~~a~~~A~~~iN~~~~~~~g~~l~~~~~~D~~~~~~~a~~---- 511 (878) T 5KCA_A 452 GGSDSIIHIGAIFDESA----------------KKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQ---- 511 (878) T ss_pred CCCCCCeEEEEEeCCCh----------------HHHHHHHHHHHHHHHhCCCCCCCCeEEEEEEEeCCCCHHHHHH---- Confidence 34467889999998764 246689999999999987777788899888 888776543333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAP-------ELSDNTRYDF 191 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~-------~l~~~~~~~~ 191 (908) .+++++. ++++++||+.++.....++.+++..++|+|++....+ .+++...+++ T Consensus 512 ~~~~l~~-------------------~~v~aviG~~~s~~~~~v~~~~~~~~ip~is~~~~~~~~~~~~~~l~~~~~~~~ 572 (878) T 5KCA_A 512 EACELMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDD 572 (878) T ss_pred HHHHHHH-------------------cCCCEEECCCCChhHHHHHHHHHHhCCCEEccCCCCCCCCCCCcccCCCCCCCc Confidence 3333332 4788999998887777888889999999999876554 3443345788 Q NP_000836.2 192 FSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL- 270 (908) Q Consensus 192 ~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~- 270 (908) +++..+++..+++++++++++++|+++++++ +++++....+.+++.+++. ++++.....++ ....++...+++++ T Consensus 573 ~~~~~~~~~~~~~al~~~l~~~~w~~v~Iv~-d~~~g~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~ 648 (878) T 5KCA_A 573 YTLSVRPPVYLHDVILRVVTEYAWQKFIIFY-DSEYDIRGIQEFLDKVSQQ-GMDVALQKVEN--NINKMITTLFDTMRI 648 (878) T ss_pred eeecCCCHHHHHHHHHHHHHHhCCCEEEEEe-cChhhHHHHHHHHHHHHHc-CCEEEEeeecC--CCCCCChHHHHHHHH Confidence 9999998888899999999889999999777 4567777778888777765 45554332222 11122222222221 Q NP_000836.2 271 ---E--TPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRY 344 (908) Q Consensus 271 ---~--~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~ 344 (908) + ..++++|++......+..+++++++.++.. ++.|+..+.+...............+......... T Consensus 649 ~~l~~~~~~~~vIil~~~~~~~~~~l~~a~~~g~~~~~~~~i~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~-------- 720 (878) T 5KCA_A 649 EELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFP-------- 720 (878) T ss_pred HHHHhhccCCcEEEEeCCHHHHHHHHHHHHHcCCCCCCcEEEEeccccCCcchhHHHHHhccceeeecCCCC-------- Confidence 0 136788888777777888999999888753 46777765443221100000000111111100000 Q NP_000836.2 345 FRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLC 424 (908) Q Consensus 345 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~ 424 (908) .........+.+.+.+.+. .|...... ...+..++..+|||++++++|++++....+ T Consensus 721 -----~~~~~~~~~~~~~~~~~~~--------------~~~~~~~~----~~~~~~~~~~~yDAv~l~a~al~~~~~~~~ 777 (878) T 5KCA_A 721 -----VPQNISQRCFRGNHRISST--------------LCDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLEDRK 777 (878) T ss_pred -----CCCChhHHhhhhhhccCCC--------------CCCCCCCC----CCCccchHHHHHHHHHHHHHHHHHHHhcCC Confidence 0000001111111111110 11100000 012345677899999999999999875432 Q NP_000836.2 425 PGY--IGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTNQLH 496 (908) Q Consensus 425 ~~~--~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~~~~ 496 (908) ... ...|... ...++..+.+.|++..|.|.+| .+.||++|++. ..+.|++++... +...+++||.|..... T Consensus 778 ~~~~~~~~c~~~~~~~~~~~~~l~~~l~~~~f~G~~G-~i~fd~~g~r~~~~~~I~~~~~~~~~~~~~~~Vg~w~~~~g 855 (878) T 5KCA_A 778 WHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTG-ELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTG 855 (878) T ss_pred CCCCCCCccCCCCCCCCcCHHHHHHHHhcCeeecCCc-cEEecCCCCcCCCeEEEEEEecCCCCCCceEEEEEEeCCCC Confidence 110 1122110 1124556788888889999998 89999999964 578888887411 1257899999997643 No 55 >4XFK_A BrovA.17370.a; transport protein, Structural Genomics, Seattle; 1.3A {Brucella ovis} Probab=99.60 E-value=5.4e-20 Score=199.14 Aligned_cols=355 Identities=14% Similarity=0.144 Sum_probs=229.2 Template_Neff=11.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ...++||++.|++++.. ..+..+..|+++|++++|+.+++. |+++++.+.|+++++..+ .+.+++ T Consensus 9 ~~~~~ig~~~plsG~~~----------~~g~~~~~g~~~a~~~iN~~gg~~-g~~i~~~~~d~~~~~~~~----~~~~~~ 73 (399) T 4XFK_A 9 AEPLKIALVETLSGPQA----------STGLLYRAAVLYQLGKINEAGGFN-GEKIQILEYDNQGGPVGA----ADRVKA 73 (399) T ss_dssp CCCCEEEEEECCSSTTC----------HHHHHHHHHHHHHHHHHHHTTCBT-TBCCEEEEEECCSHHHHH----HHHHHH T ss_pred CCCceEEEEcCCCCCch----------HHHHHHHHHHHHHHHHHHHcCCcC-CeeEEEEEEeCCCChHHH----HHHHHH Confidence 45789999999998642 356788999999999999887653 788999999987764432 233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-------FKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-------~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) ++. ++++++||+.++.....++..++. .++|+|++.+..+.+.+...+++++++ T Consensus 74 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~ 134 (399) T 4XFK_A 74 AIA-------------------DGAQIIVQGSSSAVAGQITEDVRKYNLRNKGKEVLYLNLGAEALELTGSKCHFYHFRF 134 (399) T ss_dssp HHH-------------------TTCSEEEECSCHHHHHHHHHHHHHHHHHSTTSCCEEEESSCCCGGGGTTTCCTTEEEC T ss_pred HHH-------------------cCCCEEEEcCChHHHHHHHHHHHHhccccCCCceeEEeccccchHhcCCCCCceEEEc Confidence 332 478899998877766666666665 589999877655544332246788999 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGW--NYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETP 273 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~--~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~ 273 (908) .++....+.++++++.+.+| +++++++.+++++....+.+++.+++. ++++.....+.. ....++...+++++. . T Consensus 135 ~~~~~~~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~-~~~~~~~~~~~~i~~-~ 211 (399) T 4XFK_A 135 SPNAAIRFKTVAQGMKDKGILGERAYSINQNYSWGVDVENTVVANAKEI-GYEVVDKTLHEV-NKIQDFSPYVAKIQA-A 211 (399) T ss_dssp SCCHHHHHHHHHHHHHHHTCCCSEEEEEEESSHHHHHHHHHHHHHCCCC-CCEEEEEEEECS-SCCSCCHHHHHHHHH-T T ss_pred CCcHHHHHHHHHHHHHHcCCCCceEEEEeeCChhhhhHHHHHHHHHHHc-CCEEeeeeeccc-ccCcccHHHHHHHHH-C Confidence 99988888899999888888 899999977778888888888887765 355543322221 123456667777764 5 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) ++|+|++...+..+..+++++++.|+.. .|+. . +...............+.+...... .. ... T Consensus 212 ~~~~iv~~~~~~~~~~~~~~~~~~g~~~--~~~~-~-~~~~~~~~~~~~~~~~~~~~~~~~~----------~~---~~~ 274 (399) T 4XFK_A 212 NVDTVFTGNWSNDLLLLMKAASGAGLKA--KFAT-S-FLDQPGNIGNAGAIAEGHIVSTPFN----------PE---ANG 274 (399) T ss_dssp TCSEEEECCCTHHHHHHHHHHHHHTCCS--EEEE-S-STTSTTHHHHHGGGCTTCEEEESCC----------TT---TTH T ss_pred CCCEEEEecCCHHHHHHHHHHHHcCCcc--cccc-c-cccCcchHHhchHhhcCcEEecCCC----------cc---cCC Confidence 8899988877777888999998888753 3443 2 2111100000111122322211100 00 001 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPR 433 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~ 433 (908) +....|.+.+.+.++ ..++.++..+|||+++++++++++.... T Consensus 275 ~~~~~f~~~~~~~~~---------------------------~~p~~~~~~~yda~~~l~~al~~~~~~~---------- 317 (399) T 4XFK_A 275 EASMAFAEDYKKVTG---------------------------HYPSYVEPAAVFGLQLFGEALKNVKPGE---------- 317 (399) T ss_dssp HHHHHHHHHHHHHHS---------------------------SCCCTTHHHHHHHHHHHHHHHHHSCCCS---------- T ss_pred HHHHHHHHHHHHHHC---------------------------CCCCchHHHHHHHHHHHHHHHHhcCCCC---------- Confidence 111222222222211 1123467789999999999998875311 Q NP_000836.2 434 MSTIDGKELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIG-HWTN 493 (908) Q Consensus 434 ~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg-~~~~ 493 (908) ...+++.+.++|++..|.|.+| .+.|+. ++++...+.+.+++.. +....+| .|.. T Consensus 318 -~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~~~---~~~~~~g~~~~~ 374 (399) T 4XFK_A 318 -GKINTTDIALAIENASVKTPMG-DYSMRSDDHQAKFPMVVQEVSKK---ARIKADGTEYGF 374 (399) T ss_dssp -SCCCHHHHHHHHHHCEEEETTE-EEEECTTTCBEECCEEEEEEETT---CSSBSTTSSCEE T ss_pred -CCCCHHHHHHHHHhCceecCce-eeEeCCCCCeeeecEEEEEEcCc---ccccCCCCccee Confidence 0124567788888888999988 899997 5555567788888732 3455667 6653 No 56 >5KC9_A Glutamate receptor ionotropic, delta-1; ionotropic glutamate receptor (iGluR), neurotransmission; HET: BU1, CL, NAG, EDO, PG4; 2.3A {Mus musculus} Probab=99.60 E-value=5.6e-20 Score=201.24 Aligned_cols=372 Identities=16% Similarity=0.202 Sum_probs=224.4 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~ 120 (908) .+.+++||+++|.++. ....|+++|++++|+++++++++++++.+.|++ +++..+. +.+ T Consensus 3 ~~~~i~Ig~l~p~~g~----------------~~~~~~~~A~~~in~~~~~~~~~~l~~~~~d~~~~~~~~~~----~~~ 62 (428) T 5KC9_A 3 GDSIIHIGAIFEENAA----------------KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAV----QEA 62 (428) T ss_dssp --CEEEEEEEEESSCH----------------HHHHHHHHHHHHHHHHCSSSTTCEEEEEEEEECTTCHHHHH----HHH T ss_pred CCceeEEEEeecCCCh----------------HHHHHHHHHHHHHhcCCccCCCceEEEEEEEecCCCHHHHH----HHH Confidence 4578999999998752 466899999999999877766788998888864 4433222 233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. ++++++||+.++..+..++.++...++|+|++.. ++.+. ..+++++++.++.. T Consensus 63 ~~l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~-~~~~~--~~~~~~~~~~~~~~ 120 (428) T 5KC9_A 63 CDLMT-------------------QGILALVTSTGCASANALQSLTDAMHIPHLFVQR-NPGGS--PRTACHLNPSPDGE 120 (428) T ss_dssp HHHHH-------------------TCCSCEEEECCHHHHHHHHHHHHHHTCCEEECCC-CSTTS--CCCCCCCCCCCTTC T ss_pred HHHHh-------------------cCeeEEEcCCChHHHHHHHHHHHhcCCCEeeeec-CCCCC--CCcccceecCCCCC Confidence 33332 5789999998887777888889999999999854 33332 23456666555544 Q NP_000836.2 201 ----------YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFE------- 263 (908) Q Consensus 201 ----------~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~------- 263 (908) ..+.++++++++++|+++++++.+ +++....+.+.+.+++. ++++....... .+..++. T Consensus 121 ~~~~~~~p~~~~~~a~~~~l~~~~~~~v~il~~~-~~g~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~ 196 (428) T 5KC9_A 121 AYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDS-EYDIRGLQSFLDQASRL-GLDVSLQKVDK--NISHVFTSLFTTMK 196 (428) T ss_dssp CCEEECSCCCCHHHHHHHHHHHTTCSEEEEEECT-TCCGGGGHHHHHHHHHT-TCEEEEEECCS--CHHHHHHHHHHHSC T ss_pred cceeccCCChhHHHHHHHHHHHcCCcEEEEEEcC-hHHHHHHHHHHHHHHhh-CCcEEEEEcCC--CcccccHHHHHHhh Confidence 578888998888899999999954 46777777777777665 35554322111 1111222 Q NP_000836.2 264 -KIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEG-AVTILPKRASIDG 340 (908) Q Consensus 264 -~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g-~~~~~~~~~~~~~ 340 (908) ..+++++. .+++|++......+..+++++++.|+.. .+.|+..+.+...... ........+ ...+.. T Consensus 197 ~~~l~~l~~--~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~------- 266 (428) T 5KC9_A 197 TEELNRYRD--TLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEI-LDLVHSALGRMTVVRQ------- 266 (428) T ss_dssp HHHHHHHHH--HTTEEEEESCHHHHHHHHHHHHHTTCCCTTCEEEEECSCCCHHHH-HHHHHHCSSEEEEEEE------- T ss_pred HHHHHHHhh--cccEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEEecCCcCCccH-HHHHhccCcceEEEEe------- Confidence 44555542 3788877777777888999998888754 3566665432211100 000000111 111100 Q NP_000836.2 341 FDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420 (908) Q Consensus 341 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~ 420 (908) + . ...+....|.+.+.+.+.. .|..... ....+..++..+|||++++++|++++. T Consensus 267 ---~-~----~~~~~~~~f~~~~~~~~~~-------------~~~~~~~----~~~~~~~~~~~~yda~~~~~~al~~~~ 321 (428) T 5KC9_A 267 ---I-F----PSAKDNQKCMRNNHRISSL-------------LCDPQEG----YLQMLQISNLYLYDSVLMLANAFHRKL 321 (428) T ss_dssp ---C-C----CCCCCTTTTEETTEECCST-------------TTSCCTT----TGGGSCHHHHHHHHHHHHHHHHHHHHH T ss_pred ---c-C----CCchHHHHHHHHHHHchhh-------------hcCCCCC----cchhcccHHHHHHHHHHHHHHHHHHHH Confidence 0 0 0011112222223222210 0100000 001234567889999999999999886 Q NP_000836.2 421 KDLCPG--YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTN 493 (908) Q Consensus 421 ~~~~~~--~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~ 493 (908) ...+.. ....|... ...++..+.+.|++..|.|.+| .+.|+++|++. ..+.+++++... +...++.||.|+. T Consensus 322 ~~~~~~~~~~~~c~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~vg~w~~ 400 (428) T 5KC9_A 322 EDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTG-VMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDS 400 (428) T ss_dssp HTTCCCCCCCCCSSSTTCCCCTTHHHHHHHHHTCEEEETTE-EEECCTTSBCCCCEEEEEEEEEETTTEEEEEEEEEEET T ss_pred HcCCCCCcCCCcccCCCCCCCcchHHHHHHHHcCeeecccc-eEEECCCCCCCeEEEEEEeceeeccCCCCeEEEEEEeC Confidence 532110 01122110 1124556778888888999999 89999999886 578888877421 1256899999997 Q NP_000836.2 494 QL 495 (908) Q Consensus 494 ~~ 495 (908) .. T Consensus 401 ~~ 402 (428) T 5KC9_A 401 EK 402 (428) T ss_dssp TT T ss_pred CC Confidence 64 No 57 >6JFY_A Glutamate receptor ionotropic, kainate 3; Glutamate receptor, Kainate, SYM, MEMBRANE; 7.4A {Rattus norvegicus} Probab=99.58 E-value=1.1e-19 Score=216.68 Aligned_cols=373 Identities=15% Similarity=0.201 Sum_probs=238.9 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAK-GERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~-~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. .. ..+.....|+++|++++|+.+++++|+++++++.|++ +++..+ .+.+ T Consensus 2 ~~~i~ig~~~~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~~~g~~l~l~~~d~~~~~~~~~----~~~~ 67 (809) T 6JFY_A 2 PHVIRIGGIFEYADGPNA----------QVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEA----TKKA 67 (809) T ss_dssp -CEEECCBCEEESSGGGC----------SSCCHHHHHHHHHHHHHHHCTTSCSSCEEECCCCEEESSCHHHH----HHHH T ss_pred CceeEEEEeeecCCCCcc----------ccccHHHHHHHHHHHHHhcCCccCCCceeEEeeEecCCCChHHH----HHHH Confidence 468999999999864 21 3567889999999999999887777889999999977 453322 2233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++++++|+.++..+.++++.++..++|++++.++++.+.+ ..++++++.|++. T Consensus 68 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 126 (809) T 6JFY_A 68 CDQLA-------------------LGVVAIFGPSQGSTTNAVQSICNALEVPHIQLRWKHHPLDN--KDTFYVNLYPDYA 126 (809) T ss_dssp HHHHH-------------------HCCSCCBCCSCTTTHHHHHHHHHHTTCCCBCCSCCCCCSSC--CCSSCCCCCCCHH T ss_pred HHHHh-------------------cCccEEECCCCchHHHHHHHHHHHhCCCEEEEEecCCCCCC--CCeEEEEeeCCHH Confidence 33322 47899999888877778888889999999998876665443 2577899999999 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++++++++++++|+++++++ +++++....+.+++.+++. ++++.... +. .+..++...++++++ .++|+|++ T Consensus 127 ~~~~~~~~~l~~~~~~~v~iv~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~-~~--~~~~~~~~~~~~l~~-~~~~~vv~ 200 (809) T 6JFY_A 127 SLSHAILDLVQSLKWRSATVVY-DDSTGLIRLQELIMAPSRY-NIRLKIRQ-LP--IDSDDSRPLLKEMKR-GREFRIIF 200 (809) T ss_dssp HHHHHHHHHHHHHTCSCCCEEE-CSTHHHHHHHHHHTGGGTS-CCCCCEEE-CC--SSSCCCHHHHHHHHH-TTCCEEEE T ss_pred HHHHHHHHHHHHcCCCEEEEEE-cCCchHHHHHHHhhCcccc-CeeEEEEe-CC--CCCcccHHHHHHHHh-CCceEEEE Confidence 9999999999888999999999 6778888888888888775 46665433 22 223456677777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..++++++++|+.. .+.|+..+.+...... ........+...... + . ...+....| T Consensus 201 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~----------~-~----~~~~~~~~f 264 (809) T 6JFY_A 201 DCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDL-EPYRYSGVNLTGFRI----------L-N----VDNPHVSAI 264 (809) T ss_dssp CSCHHHHHHHHHHHHHTTCCCTTCEEECCSSCTTSSCC-HHHHTTCCEEECCBC----------S-C----TTCHHHHHH T ss_pred ECCHHHHHHHHHHHHHccCcCCCeEEEEeeCCcccCCC-cccccCCceeEEEEE----------e-e----CCCchHHHH Confidence 877777888999999888754 3456654432211100 000000011110000 0 0 001111122 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) .+.+++.+..... ..|... ....++.++..+|||++++++|++++....+.. ..|... ...+ T Consensus 265 ~~~~~~~~~~~~~---------~~~~~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 327 (809) T 6JFY_A 265 VEKWSMERLQAAP---------RAESGL------LDGVMMTDAALLYDAVHIVSVTYQRAPQMTVNS--LQCHRHKAWRF 327 (809) T ss_dssp HHHHHHHCCC--------------------------CCCCHHHHHHHHHHHHHHHHHHSSCCCCCCC--CCSSSCCCCHH T ss_pred HHHhhHHHHhhCC---------cccCCc------CCCCcchHHHHHHHHHHHHHHHHHhCcCCCCcc--ccccccccccc Confidence 2222222110000 000000 001234567889999999999999987532111 111111 1124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDA-P-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++.+.++|++..|.|.+| ++.||++|++ . ..+.+.+++ ++.++.+|.|.+. T Consensus 328 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~i~~~~----~~~~~~v~~~~~~ 380 (809) T 6JFY_A 328 GGRFMNFIKEAQWEGLTG-RIVFNKTSGLRTDFDLDIISLK----EDGLEKVGVWSPA 380 (809) T ss_dssp HHHHHHHHHTCCEEETTE-EECCBTTTTBCCCCCEEEEEEE----TTEEEEEEEEETT T ss_pred hhHHHHHHHHhccCCCcc-cEEEecCCCceeeeEEEEEEec----ccCceEeEEEeCC Confidence 567888888889999988 8999986443 3 266777776 2568888988764 No 58 >4GPA_A Glutamate receptor 4; PBP fold, GLUTAMATE RECEPTOR, LIGAND-GATED; HET: NAG; 2.25A {Rattus norvegicus} Probab=99.58 E-value=1.1e-19 Score=196.06 Aligned_cols=361 Identities=14% Similarity=0.180 Sum_probs=224.0 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLL-SNITLGVRI-LDTCSRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il-~g~~l~~~~-~d~~~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. ....|+++|++++|+++++. +++++++.+ .|+.+++.. ..+.+ T Consensus 3 ~~~i~ig~~~~~~~~----------------~~~~~~~~a~~~~n~~~~~~~~~~~l~~~~~~~~~~~~~~----~~~~~ 62 (389) T 4GPA_A 3 PSSVQIGGLFIRNTD----------------QEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFA----VTNAF 62 (389) T ss_dssp CSEEEEEEEECTTCH----------------HHHHHHHHHHHHHHTCSCTTTCSSEEEEEEEECSSCCHHH----HHHHH T ss_pred CCceeeeeEEecCCH----------------HHHHHHHHHHHHHhcCCCcCCCCceeeeeeeecCCCCHHH----HHHHH Confidence 568999999998752 56789999999999876542 346777664 344444332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. +++++|||+.++.....++.++...+||+|++.+..+ ..+++++++.++ T Consensus 63 ~~~~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~-- 116 (389) T 4GPA_A 63 CSQYS-------------------RGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTE-----GESQFVLQLRPS-- 116 (389) T ss_dssp HHHHH-------------------TTCSEEEECCCTTTHHHHHHHHHHTTCEEEECSCCCS-----SCCSSEEECSCC-- T ss_pred HHHHh-------------------hCeeEEEeCCCchHHHHHHHHHHHcCCcEEeCCCCCC-----CCcccEEEeecc-- Confidence 33332 4788999988777777788888999999999876543 236788888887 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+.++++++++++|+++++++.++ ++....+.+++.+++. ++++....... .+..++...+++++. .++++|++ T Consensus 117 -~~~~~~~~~~~~~~~~v~il~~~~-~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~i~~-~~~~~vv~ 190 (389) T 4GPA_A 117 -LRGALLSLLDHYEWNCFVFLYDTD-RGYSILQAIMEKAGQN-GWHVSAICVEN--FNDVSYRQLLEELDR-RQEKKFVI 190 (389) T ss_dssp -CHHHHHHHHHHTTCCEEEEEECST-TCSHHHHHHHHHHHTT-TCEEEEEECTT--CCHHHHHHHHHHHHH-HTCCEEEE T ss_pred -hHHHHHHHHHHcCCcEEEEEEcCh-hHHHHHHHHHHHHhhc-CCeEEEEEeeC--CCCccHHHHHHHHHh-cCCcEEEE Confidence 567788888888999999999655 7777778888877765 35554321111 122345566777763 57898888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..+++++++.|+.. .+.|+..+.+...... ........+...... .. ...+....| T Consensus 191 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~-----------~~----~~~~~~~~f 254 (389) T 4GPA_A 191 DCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISL-ERFIHGGANVTGFQL-----------VD----FNTPMVTKL 254 (389) T ss_dssp ECCHHHHHHHHHHHHHHTCSBTTCEEEECSSBGGGSCC-HHHHHHBCEEEEEEC-----------SC----TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHcCCCCCCeEEEEEcCCccccCh-HHhccCCeeEEEEEE-----------ec----CCCHHHHHH Confidence 776667788999998888753 3556665432211100 000000111111100 00 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.|++.++.. |... ...+..++..+||++++++++++++....+. .....|... T Consensus 255 ~~~~~~~~~~~-------------~~~~-------~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 314 (389) T 4GPA_A 255 MDRWKKLDQRE-------------YPGS-------ETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANP 314 (389) T ss_dssp HHHHTTSCTTT-------------STTT-------TSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCTTCCCCTTCSS T ss_pred HHHHHHhcccc-------------CCCC-------CCCCCcHHHHHHHHHHHHHHHHHHHHhCCCCcccCCCCCccccCC Confidence 33333322210 0000 0113456778999999999999987643211 001122210 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQLH 496 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~~ 496 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ ++.++.||.|+.... T Consensus 315 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~g 374 (389) T 4GPA_A 315 AAPWGQGIDMERTLKQVRIQGLTG-NVQFDHYGRRVNYTMDVFELK----STGPRKVGYWNDMDK 374 (389) T ss_dssp CCCCTTHHHHHHHHHTCEEEETTE-EEEBCTTSCBCSCEEEEEEEE----TTEEEEEEEEETTTE T ss_pred CCcccchHHHHHHHhcCCcccCCe-eeEECCCCceeeeeEEEEEcc----cCCCEEeEEEeCCcc Confidence 1124556778888888999988 899999898875 78888887 246889999987643 No 59 >5EWM_A NMDA glutamate receptor subunit, Glutamate; Glutamate receptor, allosteric modulator, GluN2B; HET: MAN, 5SM, NAG, BMA; 2.76A {Xenopus laevis} Probab=99.58 E-value=1.2e-19 Score=195.95 Aligned_cols=351 Identities=18% Similarity=0.242 Sum_probs=221.3 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.+ ....|+++|++++|+.++ +.++++++...|+..++..+. +.+.+ T Consensus 2 ~~~i~Ig~~~~~~------------------~~~~~~~~a~~~~n~~~~-~~~~~l~~~~~d~~~~~~~~~----~~~~~ 58 (390) T 5EWM_A 2 PKIVNIGAVLSTK------------------KHEQIFREAVNQANKRHF-TRKIQLQATSVTHRPNAIQMA----LSVCE 58 (390) T ss_dssp CEEEEEEEEESSH------------------HHHHHHHHHHHHHHHHSC-CSSEEEEEEEEECCSSHHHHH----HHCCC T ss_pred CcceEEEEEeCch------------------hHHHHHHHHHHHHhhhcC-CCCceEEEEEecCCCCHHHHH----HHHHH Confidence 4678999999875 245789999999998753 356778877666555433222 22222 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAA-----ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-----~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) ++. .+++++++|+. ++..+..++.++...++|+|++.+..+.+++...+++++++.+ T Consensus 59 ~~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 120 (390) T 5EWM_A 59 DLI------------------SSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 120 (390) T ss_dssp CCG------------------GGTEEEEEECCCC-----CCSHHHHHHHHHTTCCEEESSCCCGGGGCTTTSTTEEESSC T ss_pred HHh------------------hcCcEEEEECCCCCCCCCCCchHHHHHHHhcCCCEEEccCCCcccccccccceEEecCC Confidence 221 15788999873 3344455677888899999998887766654445788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQS-------QKIP------------REPR 258 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~-------~~~~------------~~~~ 258 (908) +...++.++++++++++|+++++++.++.++....+.+++.+++. ++++... ..+. ...+ T Consensus 121 ~~~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 199 (390) T 5EWM_A 121 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGK-ESKSKKRNYENLDQLSYDNKRGPKADKVLQFEPG 199 (390) T ss_dssp CGGGGHHHHHHHHHHHTCCEEEEEEESSHHHHHHHHHHHHHHCC------------------------CEEEEEEEECTT T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEecCCcchHHHHHHHHHHhcC-CccccccccccccccccccCCCCCcccceecCCC Confidence 998889999999988999999999987778888888888877765 3443210 0000 0011 Q NP_000836.2 259 PGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRAS 337 (908) Q Consensus 259 ~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~ 337 (908) ..++...+++++. .++|+|++.........+++++++.++.. ++.|+..+.+..... ......+.+. T Consensus 200 ~~~~~~~~~~l~~-~~~~~ii~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~----~~~~~~~~~~------- 267 (390) T 5EWM_A 200 TKNLTALLLEAKE-LEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSA----LRYAPDGIIG------- 267 (390) T ss_dssp CSCCHHHHHHHHH-SSCCEEEEECCHHHHHHHHHHHHHTTCSSTTCEEECCSGGGSHHH----HHHCCTTCEE------- T ss_pred chhHHHHHHHHHh-CCCeEEEEECCHHHHHHHHHHHHHcCCCCCCEEEEEecccCCcch----hhcCCCeEEE------- Confidence 2345556666663 57899888776667778888888877743 456776543321100 0000000000 Q NP_000836.2 338 IDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALH 417 (908) Q Consensus 338 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~ 417 (908) + . . ..+..++..+|||++++++|++ T Consensus 268 ---------------------~-~----~-----------------------------~~~~~~~~~~ydav~~~~~al~ 292 (390) T 5EWM_A 268 ---------------------L-Q----L-----------------------------INGKNESAHISDAVAVVAQAIH 292 (390) T ss_dssp ---------------------E-E----E-----------------------------TTTTCHHHHHHHHHHHHHHHHH T ss_pred ---------------------E-E----E-----------------------------cCCCchHHHHHHHHHHHHHHHH Confidence 0 0 0 0112356789999999999999 Q NP_000836.2 418 NMHKDLCPG-YIGLCPRMS--TIDGKELLGYIRA-VNFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 418 ~~~~~~~~~-~~~~~~~~~--~~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) +.....+.. ....|.... ...+..+.+.+++ ..|.|.+| .+.||++|++ ...+.+++++ .+.++.+|.|+ T Consensus 293 ~~~~~~~~~~~~~~c~~~~~~~~~~~~l~~~l~~~~~~~g~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~vg~~~ 367 (390) T 5EWM_A 293 ELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFN 367 (390) T ss_dssp HHTTSSSCCCCCSSSTTCCSCCTTHHHHHHHHHTCCEEEETTE-EEEECTTSCEESCCEEEEEEE----TTEEEEEEEEC T ss_pred HHHhccCCCCCCCccCCCCchhccHHHHHHHHHcCCCCCCCcc-cEEECCCCCcccceEEEEEcC----CCeEEEEEEEe Confidence 987543211 011222110 1134456667765 46888888 8999999998 4788888887 35789999998 Q NP_000836.2 493 NQLH-LKVEDMQWAHR 507 (908) Q Consensus 493 ~~~~-~~~~~i~w~~~ 507 (908) .... .+...+.|+++ T Consensus 368 ~~~~~~~~~~~~w~~~ 383 (390) T 5EWM_A 368 GSYIIQNDRKIIWPGG 383 (390) T ss_dssp SSCEEECSSCCCCSSS T ss_pred CceeeecCCcccCCCC Confidence 6522 22224678653 No 60 >3H6G_A Glutamate receptor, ionotropic kainate 2; MEMBRANE PROTEIN GLYCOPROTEIN, Cell junction; HET: TLA, NAG; 2.697A {Rattus norvegicus} Probab=99.57 E-value=1.2e-19 Score=196.12 Aligned_cols=373 Identities=17% Similarity=0.207 Sum_probs=225.6 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~~ 121 (908) .++++||+++|.++.. .+.....|+++|++++|+++++++++++++...|+.. +...+ .+.+. T Consensus 2 ~~~i~ig~~~~~~g~~------------~~~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~~~----~~~~~ 65 (395) T 3H6G_A 2 THVLRFGGIFEYVESG------------PMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA----SKKAC 65 (395) T ss_dssp CEEEEEEEEEEESSSC------------SCCHHHHHHHHHHHHHHHCSSSSSSEEEEEEEEEEETTCHHHH----HHHHH T ss_pred CCeEEEEEEeccCCCC------------CCcHHHHHHHHHHHHHhcCcccCCCCEEEEEEEecCcchhHHH----HHHHH Confidence 4679999999998742 3567889999999999998877767888887777654 32211 11111 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. .++++++||+.++.....++.++...++|+|++.+..+.+.. .+++++++.++... T Consensus 66 ~~~-------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 124 (395) T 3H6G_A 66 DQL-------------------SLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--KDSFYVSLYPDFSS 124 (395) T ss_dssp HHH-------------------HHCCSCEECCSSHHHHHHHHHHHHHTTCCEEECSCCCCCTTC--CCCSEEEEEECHHH T ss_pred HHH-------------------hcCceEEECCCCHHHHHHHHHHHHHhCCCEEEeecCccccCC--CCceeEEcCCCHHH Confidence 111 147889999988877777888888999999998775544332 35788999999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++++++++++++|+++++++.+ .++....+.+.+.+++. ++++... .+. ....++...+++++. .+++++++. T Consensus 125 ~~~~~~~~~~~~~~~~v~il~~~-~~~~~~~~~~~~~~~~~-~~~v~~~-~~~--~~~~~~~~~~~~l~~-~~~~~iv~~ 198 (395) T 3H6G_A 125 LSRAILDLVQFFKWKTVTVVYDD-STGLIRLQELIKAPSRY-NLRLKIR-QLP--ADTKDAKPLLKEMKR-GKEFHVIFD 198 (395) T ss_dssp HHHHHHHHHHHTTCSEEEEEESS-THHHHHTHHHHTGGGTS-SCEEEEE-ECC--SSGGGGHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCEEEEEEeC-CccHHHHHHHHHCcCcc-CceEEEE-ECC--CCCCCcHHHHHHHHh-CCCeEEEEE Confidence 88999999888899999999954 37766677777776664 3554432 222 223355666777753 477888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+........... . .....+... ..+..+ . ...+....+. T Consensus 199 ~~~~~~~~~l~~~~~~g~~~~~~~~~~~~~~~~~~~~-~--~~~~~~~~~--------~~~~~~-~----~~~~~~~~~~ 262 (395) T 3H6G_A 199 CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV-E--PYRYSGVNM--------TGFRIL-N----TENTQVSSII 262 (395) T ss_dssp SCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGBCC-T--TTTTSCCEE--------EEEECS-C----TTSHHHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCcCCeEEEEeeCCcccCcc-h--hhccCCeee--------EEEEEe-c----CCCcchHHHH Confidence 76677788899998888753 2345543211100000 0 000001000 000000 0 0001111222 Q NP_000836.2 361 EFWEENF-GCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 361 ~~~~~~~-~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) +.|.+.+ .+.. .+... .....+..++..+|||+++++++++++....+.. ..|... ...+ T Consensus 263 ~~~~~~~~~~~~-----------~~~~~-----~~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 324 (395) T 3H6G_A 263 EKWSMERLQAPP-----------KPDSG-----LLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSS--LQCNRHKPWRF 324 (395) T ss_dssp HHHHHC-----------------CCSSC-----BCTTCCCHHHHHHHHHHHHHHHHHHTCTTCCCCC--CCTTSCCCCTT T ss_pred HHHHHHhhcCCC-----------CCCCC-----ccCcCCChHHHHHHHHHHHHHHHHHhccccCCCC--CCCCCCCCccc Confidence 2222211 1100 00000 0001134567889999999999999986543211 112111 1123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++...+.+..++.. ++.++.||.|.... T Consensus 325 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~~~~~~--~~~~~~vg~~~~~~ 378 (395) T 3H6G_A 325 GTRFMSLIKEAHWEGLTG-RITFNKTNGLRTDFDLDVISLK--EEGLEKIGTWDPAS 378 (395) T ss_dssp HHHHHHHHHHCEEEETTE-EEECCTTTSEECCCCEEEEEEE--TTEEEEEEEEETTT T ss_pred cHHHHHHHHhccccCCcc-eEEEcCCCCcccceEEEEEEee--ccccEEEEEEeCCC Confidence 456777888888999988 8999987666554444333321 35789999998764 No 61 >3H6G_B Glutamate receptor, ionotropic kainate 2; MEMBRANE PROTEIN GLYCOPROTEIN, Cell junction; HET: NAG, TLA; 2.697A {Rattus norvegicus} Probab=99.57 E-value=1.2e-19 Score=196.12 Aligned_cols=373 Identities=17% Similarity=0.207 Sum_probs=226.1 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~~ 121 (908) .++++||+++|.++.. .+.....|+++|++++|+++++++++++++...|+.. +...+ .+.+. T Consensus 2 ~~~i~ig~~~~~~g~~------------~~~~~~~~~~~a~~~~n~~~~~~~~~~l~~~~~d~~~~~~~~~----~~~~~ 65 (395) T 3H6G_B 2 THVLRFGGIFEYVESG------------PMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA----SKKAC 65 (395) T ss_dssp CEEEEEEEEEEESSSC------------SCCHHHHHHHHHHHHHHHCSSSSSSEEEEEEEEEEETTCHHHH----HHHHH T ss_pred CCeEEEEEEeccCCCC------------CCcHHHHHHHHHHHHHhcCcccCCCCEEEEEEEecCcchhHHH----HHHHH Confidence 4679999999998742 3567889999999999998877767888887777654 32211 11111 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. .++++++||+.++.....++.++...++|+|++.+..+.+.. .+++++++.++... T Consensus 66 ~~~-------------------~~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 124 (395) T 3H6G_B 66 DQL-------------------SLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--KDSFYVSLYPDFSS 124 (395) T ss_dssp HHH-------------------HHCCSCEECCSSHHHHHHHHHHHHHTTCCEEECSCCCCCTTC--CCCSEEEEEECHHH T ss_pred HHH-------------------hcCceEEECCCCHHHHHHHHHHHHHhCCCEEEeecCccccCC--CCceeEEcCCCHHH Confidence 111 147889999988877777888888999999998775544332 35788999999888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++++++++++++|+++++++.+ .++....+.+.+.+++. ++++... .+. ....++...+++++. .+++++++. T Consensus 125 ~~~~~~~~~~~~~~~~v~il~~~-~~~~~~~~~~~~~~~~~-~~~v~~~-~~~--~~~~~~~~~~~~l~~-~~~~~iv~~ 198 (395) T 3H6G_B 125 LSRAILDLVQFFKWKTVTVVYDD-STGLIRLQELIKAPSRY-NLRLKIR-QLP--ADTKDAKPLLKEMKR-GKEFHVIFD 198 (395) T ss_dssp HHHHHHHHHHHTTCSEEEEEESS-THHHHHTHHHHTGGGTS-SCEEEEE-ECC--SSGGGCHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCEEEEEEeC-CccHHHHHHHHHCcCcc-CceEEEE-ECC--CCCCCcHHHHHHHHh-CCCeEEEEE Confidence 88999999888899999999954 37766677777776664 3554432 222 223355666777753 477888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ........+++++++.|+.. .+.|+........... . .....+... ..+..+ . ...+....+. T Consensus 199 ~~~~~~~~~l~~~~~~g~~~~~~~~~~~~~~~~~~~~-~--~~~~~~~~~--------~~~~~~-~----~~~~~~~~~~ 262 (395) T 3H6G_B 199 CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV-E--PYRYSGVNM--------TGFRIL-N----TENTQVSSII 262 (395) T ss_dssp SCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGBCC-T--TTTTSCCEE--------EEEECS-C----TTSHHHHHHH T ss_pred CCHHHHHHHHHHHHHcCCCcCCeEEEEeeCCcccCcc-h--hhccCCeee--------EEEEEe-c----CCCcchHHHH Confidence 76677788899998888753 2345543211100000 0 000001000 000000 0 0001111222 Q NP_000836.2 361 EFWEENF-GCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 361 ~~~~~~~-~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) +.|.+.+ .+.. .+... .....+..++..+|||+++++++++++....+.. ..|... ...+ T Consensus 263 ~~~~~~~~~~~~-----------~~~~~-----~~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 324 (395) T 3H6G_B 263 EKWSMERLQAPP-----------KPDSG-----LLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSS--LQCNRHKPWRF 324 (395) T ss_dssp HHHHHHHTTSCC-----------CSSSC-----BCTTCCCHHHHHHHHHHHHHHHHHHTCTTCCCCC--CCTTSCCCCTT T ss_pred HHHHHHhhcCCC-----------CCCCC-----ccCcCCChHHHHHHHHHHHHHHHHHhccccCCCC--CCCCCCCCccc Confidence 2222211 1100 00000 0001134567889999999999999986543211 112111 1123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) +..+.+.|++..|.|.+| ++.||++|++...+.+..++.. ++.++.||.|.... T Consensus 325 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~~~~~~--~~~~~~vg~~~~~~ 378 (395) T 3H6G_B 325 GTRFMSLIKEAHWEGLTG-RITFNKTNGLRTDFDLDVISLK--EEGLEKIGTWDPAS 378 (395) T ss_dssp HHHHHHHHHTCEEEETTE-EEECCTTTSEECCCCEEEEEEE--TTEEEEEEEEETTT T ss_pred cHHHHHHHHhccccCCcc-eEEEcCCCCcccceEEEEEEee--ccccEEEEEEeCCC Confidence 456777888888999988 8999987666554444333321 35789999998764 No 62 >6JFY_B Glutamate receptor ionotropic, kainate 3; Glutamate receptor, Kainate, SYM, MEMBRANE; 7.4A {Rattus norvegicus} Probab=99.57 E-value=1.2e-19 Score=216.12 Aligned_cols=373 Identities=15% Similarity=0.201 Sum_probs=239.8 Template_Neff=11.300 Q NP_000836.2 43 DGDIILGGLFPVHAK-GERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFV 120 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~-~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~ 120 (908) +++++||+++|.++. .. ..+.....|+++|++++|+.+++++|+++++++.|++ +++..+ .+.+ T Consensus 2 ~~~i~ig~~~~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~~~g~~l~l~~~d~~~~~~~~~----~~~~ 67 (809) T 6JFY_B 2 PHVIRIGGIFEYADGPNA----------QVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEA----TKKA 67 (809) T ss_pred CCceEEEEEEeCCCCchh----------HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEeCCCCCHHHH----HHHH Confidence 468999999999864 21 3567889999999999999887777889999999977 453332 2233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++++++|+.++..+.+++..++..++|++++.++++.+.+ ..++++++.|++. T Consensus 68 ~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 126 (809) T 6JFY_B 68 CDQLA-------------------LGVVAIFGPSQGSTTNAVQSICNALEVPHIQLRWKHHPLDN--KDTFYVNLYPDYA 126 (809) T ss_pred HHHHH-------------------cCCCEEEcCCCcHHHHHHHHHHHHHCCCEEeCCCCCcccCC--CCCCeeecCCCHH Confidence 33322 47899999888877778888889999999998876665443 2577999999999 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+++++++++++++|+++++++ +++++....+.+++.+++. ++++.... +. .+..++...++++++ .++|+|++ T Consensus 127 ~~~~~~~~~l~~~~~~~v~iv~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~-~~--~~~~~~~~~~~~l~~-~~~~~vv~ 200 (809) T 6JFY_B 127 SLSHAILDLVQSLKWRSATVVY-DDSTGLIRLQELIMAPSRY-NIRLKIRQ-LP--IDSDDSRPLLKEMKR-GREFRIIF 200 (809) T ss_pred HHHHHHHHHHHHhCCCEEEEEE-eChhhHHHHHHHHHHHHHC-CCEEEeee-cC--CCCCCcHHHHHHHHH-hCCCEEEE Confidence 9999999999888999999999 6778888888888888775 46665433 22 223456677777763 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..++++++++|+.. .+.|+..+.+...... ........+...... + . ...+....| T Consensus 201 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~----------~-~----~~~~~~~~f 264 (809) T 6JFY_B 201 DCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDL-EPYRYSGVNLTGFRI----------L-N----VDNPHVSAI 264 (809) T ss_pred eCCHHHHHHHHHHHHHcCCCCCCeeEEEecCCCCCCch-HhhcCCceeEEEEec----------C-C----CCChHHHHH Confidence 877777888999999888754 2456654432211100 000000011110000 0 0 001111122 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STID 438 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~ 438 (908) .+.+++.+..... ..|... ....++.++..+|||++++++|++++....+.. ..|... ...+ T Consensus 265 ~~~~~~~~~~~~~---------~~~~~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~--~~~~~~~~~~~ 327 (809) T 6JFY_B 265 VEKWSMERLQAAP---------RAESGL------LDGVMMTDAALLYDAVHIVSVTYQRAPQMTVNS--LQCHRHKAWRF 327 (809) T ss_pred HHHHHHHHCCCCC---------CCCCCC------CCCCCCHHHHHHHHHHHHHHHHHHHhcCCCCCc--cccccCCCccc Confidence 2222222110000 000000 001234567889999999999999987532111 111111 1124 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDA-P-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++.+.++|++..|.|.+| ++.||++|++ . ..+.+.+++ ++.++.+|.|.+. T Consensus 328 ~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~~i~~~~----~~~~~~v~~~~~~ 380 (809) T 6JFY_B 328 GGRFMNFIKEAQWEGLTG-RIVFNKTSGLRTDFDLDIISLK----EDGLEKVGVWSPA 380 (809) T ss_pred HHHHHHHHHhcCcCCCCC-cEEecCCCCccceeEEEEEecc----CCceEEeEEEeCC Confidence 567788888889999988 8999986443 3 266777776 2568888988764 No 63 >5L2E_B Cerebellin-1; Synapse Protein, Cell Surface Protein; 4.152A {Rattus norvegicus} Probab=99.57 E-value=1.3e-19 Score=211.78 Aligned_cols=379 Identities=16% Similarity=0.219 Sum_probs=233.2 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~ 120 (908) .+++++||+++|.++ .....|++.|++++|+++++++|+++++++ .|+++++..+.+.+ T Consensus 2 ~~~~i~Ig~~~~~~~----------------~~~~~~~~~a~~~iN~~~~~~~g~~i~~~~~~d~~~~~~~a~~~~---- 61 (688) T 5L2E_B 2 SDSIIHIGAIFDESA----------------KKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEA---- 61 (688) T ss_dssp -CCCEEEEEEEETTC----------------HHHHHHHHHHHHHHHHCSSSSTTCCEEEEEEEECTTCHHHHHHHH---- T ss_pred CCceeeeEEEecCCC----------------chhHHHHHHHHHHHhcCcccccCcceEEEEEEeCCCCHHHHHHHH---- Confidence 357899999999875 245689999999999988777789999998 88887754433333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAP-------ELSDNTRYDFFS 193 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~-------~l~~~~~~~~~~ 193 (908) .+++. ++++++||+.++..+..++.++...++|+|++.+..+ .+++...+++++ T Consensus 62 ~~l~~-------------------~~v~~viG~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~l~~~~~~~~~~ 122 (688) T 5L2E_B 62 CELMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 122 (688) T ss_dssp HHHHH-------------------HCCSCEEEEECHHHHHHHHHHHHHHTCCEEEEECCGGGCCCCCCCCCCCTTSCCCE T ss_pred HHHHH-------------------cCeeEEEecCCcchHHHHHHHHHHcCCCEEEeecCCCCCCCCCcccccCCCCCceE Confidence 33322 4788999998887777788888999999999876554 333334578899 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE------PRPGEFEKIIK 267 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~------~~~~~~~~~~~ 267 (908) ++.+++..++.++++++++++|+++++++++ +++....+.+.+.+++. ++++.....++.. ....+....++ T Consensus 123 ~~~~~~~~~~~~l~~~~~~~~~~~v~i~~~~-~~g~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~l~ 200 (688) T 5L2E_B 123 LSVRPPVYLNEVILRVVTEYAWQKFIIFYDS-EYDIRGIQEFLDKVSQQ-GMDVALQKVENNINKMITTLFDTMRIEELN 200 (688) T ss_dssp EECSCCCCHHHHHHHHHHHTTCCEEEEEECT-TCCGGGGHHHHHHHHHT-TCEEEEEECCSCHHHHHHHHHHHSCHHHHH T ss_pred EEecCChhHHHHHHHHHHHhCCcEEEEEEcC-ccchHHHHHHHHHHHhc-CcchHHHHhhchhHHhHHhhhccccHHHHH Confidence 9999988889999999988899999988754 47777777888777765 4665443222110 00122334445 Q NP_000836.2 268 RLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFR 346 (908) Q Consensus 268 ~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~ 346 (908) ++. ..+++|++......+..+++++++.|+.. ++.|+..+.+...............+........ . T Consensus 201 ~~~--~~~~~ii~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~ 268 (688) T 5L2E_B 201 RYR--DTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTF----------P 268 (688) T ss_dssp HHH--HHTTEEEEESCHHHHHHHHHHHHHTTSSCTTCEEEEECSCCCHHHHHHHHHHCCSEEEEEEECC----------C T ss_pred HHH--HhccEEEEEcCHHHHHHHHHHHHHccCcCCCeEEEEecCCcccCChHHHHhhccceEEEEEecC----------C Confidence 443 25777777766667788999998888753 4567766543322110000001111111111000 0 Q NP_000836.2 347 SRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 347 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) .........+.+.+++.+. .|...... ...+..++..+|||++++++|++++....+.. T Consensus 269 ---~~~~~~~~~~~~~~~~~~~--------------~~~~~~~~----~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~ 327 (688) T 5L2E_B 269 ---VPQNISQRCFRGNHRISST--------------LCDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLQDRKWH 327 (688) T ss_dssp ---CCCSSGGGSEETTEECCHH--------------HHCTTSHH----HHTCCHHHHHHHHHHHHHHHHHHHHHHTTCCC T ss_pred ---CCchhhhhccccCcccCCC--------------cCCCCCCc----cccccchHHHHHHHHHHHHHHHHHHHHcCCCC Confidence 0000111112222222111 11000000 01234567789999999999999986543210 Q NP_000836.2 427 --YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITN-KSTEYKVIGHWTNQL 495 (908) Q Consensus 427 --~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~-~~~~~~~Vg~~~~~~ 495 (908) ....|... ...++..+.++|++.+|.|.+| .+.|+++|++ ...+.+++++... +...++.||.|.... T Consensus 328 ~~~~~~c~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~vg~~~~~~ 402 (688) T 5L2E_B 328 SMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTG-DLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVT 402 (688) T ss_dssp CCCCCCSSSTTCCCCTTHHHHHHHHHTCEEECSSS-EEECCTTSBCCCCCEEEEEC--------CCEEEEEEETTT T ss_pred CCCCcccccCCCCCCccchHHHHHHHhCccccccc-eEEecCCCccceeEEEEEecCCCcccCCcEEEEEEEeCCC Confidence 01122111 0114556778888889999988 8999999985 4678888887421 235789999998764 No 64 >3QEK_B NMDA glutamate receptor subunit; amino terminal domain, ion channel; HET: MSE, NAG, BMA; 2.001A {Xenopus laevis} Probab=99.57 E-value=1.3e-19 Score=195.07 Aligned_cols=349 Identities=18% Similarity=0.255 Sum_probs=220.0 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.+ ....|+++|++++|+.+ .++++++++...|+..++..+ .+.+.+ T Consensus 3 ~~~i~Ig~~~~~~------------------~~~~~~~~a~~~~n~~~-~~~~~~l~~~~~~~~~~~~~~----~~~~~~ 59 (384) T 3QEK_B 3 PKIVNIGAVLSTK------------------KHEQIFREAVNQANKRH-FTRKIQLQATSVTHRPNAIQM----ALSVCE 59 (384) T ss_dssp CCEEEEEEEESSH------------------HHHHHHHHHHHHHHHHC-----CEEEEEEEECCSSHHHH----HHHCCC T ss_pred CcceEEEEEechH------------------HHHHHHHHHHHHHhHhh-cCCCeeEEEEEecCCcCHHHH----HHHHHH Confidence 4689999999875 24578999999999864 345777777665544443222 222222 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAA-----ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-----~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) ++. .+++++++|+. ++..+..++.++...++|+|++.+..+.+.+...+++++++.| T Consensus 60 ~~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 121 (384) T 3QEK_B 60 DLI------------------SSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 121 (384) T ss_dssp CCG------------------GGTEEEEEECCC-------CCHHHHHHHHTTTCCEEESSCCCGGGGCSSSCTTEEESSC T ss_pred HHH------------------hcCcEEEEECCCCCCCCcCChHHHHHHHHhhCCCEEEccCCCccccCccccceEeecCC Confidence 221 15788999953 3344456677888899999998877666554335688999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQS-------QKIP------------REPR 258 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~-------~~~~------------~~~~ 258 (908) +....+.++++++.+++|+++++++.++.++....+.+++.+++. ++++... ..+. .... T Consensus 122 ~~~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 200 (384) T 3QEK_B 122 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGK-ESKSKKRNYENLDQLSYDNKRGPKADKVLQFEPG 200 (384) T ss_dssp CGGGGHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-HHHHHHHTC-------------CEEEEEEEECTT T ss_pred CHHHHHHHHHHHHHHcCCcEEEEEEecCcchhHHHHHHHHHHhcC-CCccccccccccccccccCCCCCCccceeecCCC Confidence 998889999999988899999999987778887778888777765 3442110 0000 0011 Q NP_000836.2 259 PGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRAS 337 (908) Q Consensus 259 ~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~ 337 (908) ..++...+++++. .++|+|++.........+++++++.|+.+ ++.|+..+.+..... ......+. T Consensus 201 ~~~~~~~~~~i~~-~~~~~ii~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~----~~~~~~~~--------- 266 (384) T 3QEK_B 201 TKNLTALLLEAKE-LEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSA----LRYAPDGI--------- 266 (384) T ss_dssp CCCCHHHHHHHHT-SSCCEEEEECCHHHHHHHHHHHHHTTCSSTTCEEEECSGGGSHHH----HHHCCTTC--------- T ss_pred chhHHHHHHHHHh-CCCeEEEEECCHHHHHHHHHHHHHcCCCCCCEEEEEeccccCCch----hhcCCCcE--------- Confidence 2345566777763 57899888877777788889888887753 456665543221100 00000000 Q NP_000836.2 338 IDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALH 417 (908) Q Consensus 338 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~ 417 (908) +... ...+..++..+|||+++++++++ T Consensus 267 -----------------------------~~~~------------------------~~~~~~~~~~~ydav~~~~~al~ 293 (384) T 3QEK_B 267 -----------------------------IGLQ------------------------LINGKNESAHISDAVAVVAQAIH 293 (384) T ss_dssp -----------------------------EEEE------------------------ETTTTCHHHHHHHHHHHHHHHHH T ss_pred -----------------------------EEEE------------------------ecCCCcchhHHHHHHHHHHHHHH Confidence 0000 00112356789999999999999 Q NP_000836.2 418 NMHKDLCPG-YIGLCPRM--STIDGKELLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 418 ~~~~~~~~~-~~~~~~~~--~~~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ++....+.. ....|... ....+..+.+.|++ ..|.|.+| ++.||++|++. ..+.+++++ ++.++.+|.|+ T Consensus 294 ~~~~~~~~~~~~~~c~~~~~~~~~~~~l~~~l~~~~~~~g~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~vg~~~ 368 (384) T 3QEK_B 294 ELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFN 368 (384) T ss_dssp HHTTSSCCCCCCSCCTTCCCCCTTHHHHHHHHHTCCEEEETTE-EECBCTTSCBCSCCEEEEEEE----TTEEEEEEEEC T ss_pred HHHhcCCCCCCCCCcCCCcchhccHHHHHHHHhcCCCCCCCCC-CEEECCCCCcCceEEEEEEcc----CCeEEEEEEEe Confidence 986532110 01122111 11234556677765 56889888 89999999986 688888887 35799999998 Q NP_000836.2 493 NQL-HLKVEDMQWA 505 (908) Q Consensus 493 ~~~-~~~~~~i~w~ 505 (908) ... .++...+.|+ T Consensus 369 ~~~~~~~~~~~~w~ 382 (384) T 3QEK_B 369 GSYIIQNDRKIIWP 382 (384) T ss_dssp SSSEEECSSCCCCT T ss_pred CCccccCCCcccCC Confidence 652 2233457774 No 65 >6LU9_D Glutamate receptor ionotropic, delta-2; Membrane protein;{Rattus norvegicus} Probab=99.57 E-value=1.3e-19 Score=217.96 Aligned_cols=374 Identities=16% Similarity=0.230 Sum_probs=233.0 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++ .....|+++|++++|+++++++|+++++.+ .|+++++..+.+. +.+ T Consensus 2 ~~i~IG~~~p~~g----------------~~~~~~~~~Ai~~in~~~~~~~g~~i~~~~~~d~~~~~~~~~~~----~~~ 61 (877) T 6LU9_D 2 SIIHIGAIFDESA----------------KKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQE----ACE 61 (877) T ss_dssp CSSEEEEEECTTT----------------HHHHHHHHHHHHHHHTCCSSCSSCCCEEEEEECCTTCHHHHHHH----HHH T ss_pred CeEEEEEEeccCc----------------cchHHHHHHHHHHHHccccccccccceeEEEEcCCCCHHHHHHH----HHH Confidence 5789999999864 246789999999999988777789999988 8887765443333 333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAP-------ELSDNTRYDFFSRV 195 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~-------~l~~~~~~~~~~~~ 195 (908) ++. +++++++|+.++..+..++..+...++|++++.++.+ .+++...++++++. T Consensus 62 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~l~~~~~~~~~~~~ 122 (877) T 6LU9_D 62 LMN-------------------QGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLS 122 (877) T ss_dssp HHH-------------------HCCSCEEEEECHHHHHHHHHHHHHHTCCEEEEECCGGGCCCCCCSCCSCTTSCCCEEE T ss_pred HHH-------------------cCeeEEEecCChhhHHHHHHHHHHcCCCEEEeecCCCCCCCCCCCcccCCCCCCeEEE Confidence 332 5789999998887777888889999999999877655 34333456788888 Q NP_000836.2 196 VPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEF--------EKIIK 267 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~--------~~~~~ 267 (908) .+++..+++++++++++++|+++++++ +++++....+.+.+.+++. ++++.....++. +..++ ...++ T Consensus 123 ~~~~~~~~~~l~~~l~~~~~~~v~il~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~--~~~~~~~~~~~~~~~~l~ 198 (877) T 6LU9_D 123 VRPPVYLNEVILRVVTEYAWQKFIIFY-DSEYDIRGIQEFLDKVSQQ-GMDVALQKVENN--INKMITTLFDTMRIEELN 198 (877) T ss_dssp CSCCCCHHHHHHHHHHHTTCSEEEEEE-CTTSCGGGSHHHHHHHHHT-TCEEEEEECCSS--HHHHHHHHHHHSCHHHHH T ss_pred ecCChhHHHHHHHHHHHhCCcEEEEEE-cCcccHHHHHHHHHHHHhc-CCceeEeecccc--hhHhHHHHHhhhcHHHHH Confidence 888777888999998888999999999 7778877778888877765 355543322221 11111 12233 Q NP_000836.2 268 RLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFR 346 (908) Q Consensus 268 ~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~ 346 (908) ++. .++|+|++......+..+++++++.|+.. .+.|+..+.+...............+........ . T Consensus 199 ~~~--~~~~~ii~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~ 266 (877) T 6LU9_D 199 RYR--DTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTF----------P 266 (877) T ss_dssp HHH--HHTTEEEEESCHHHHHHHHHHHHHTTSSCSSCEEEEECSCCCHHHHHHHHHHCSSEEEEEEEEC----------C T ss_pred HhH--HhCCeEEEEcCHHHHHHHHHHHHHcCCccCceEEEEEeCCcccccHHHHhhhhcccEEEEEecc----------C Confidence 332 36788887777777888999999888753 4567766543321110000000111111110000 0 Q NP_000836.2 347 SRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 426 (908) Q Consensus 347 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~ 426 (908) .........+.+.+++.+. .|...+.. ...+..++..+|||++++++|++++....+.. T Consensus 267 ---~~~~~~~~~f~~~~~~~~~--------------~~~~~~~~----~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~ 325 (877) T 6LU9_D 267 ---VPQNISQRCFRGNHRISST--------------LCDPKDPF----AQNMEISNLYIYDTVLLLANAFHKKLQDRKWH 325 (877) T ss_dssp ---CCSSHHHHHEETTEECCTT--------------TSCTTSHH----HHTCCHHHHHHHHHHHHHHHHHHHHHHTTCCC T ss_pred ---CCcccccccccccccccCC--------------cCCCCCCc----ccccchhHHHHHHHHHHHHHHHHHHHHcCCcc Confidence 0000011112222221111 01000000 01234567889999999999999886532110 Q NP_000836.2 427 --YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITN-KSTEYKVIGHWTNQ 494 (908) Q Consensus 427 --~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~-~~~~~~~Vg~~~~~ 494 (908) ....|... ...++..+.+++++..|.|.+| .+.||++|++ ...+.+++++..+ ..+.+..||.|... T Consensus 326 ~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~v~~~~~~ 399 (877) T 6LU9_D 326 SMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTG-DLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPV 399 (877) T ss_dssp CCCCCCSSSTTCCCCHHHHHHHHHHHTCEEECSSS-EEECCTTSBCCCCEEEEEEEEEEETTEEEEEEEEEEETT T ss_pred ccccccccCCCCCccccchHHHHHHHhcccCceee-eEEcCCCCCcccEEEEEEecccccccCCcEEEEEEEeCC Confidence 00112110 1124566888888889999998 8999999998 4688888887421 12468888988754 No 66 >1USG_A LEUCINE-SPECIFIC BINDING PROTEIN; LEUCINE-BINDING PROTEIN, PROTEIN STRUCTURE, ABC; 1.53A {ESCHERICHIA COLI} SCOP: c.93.1.1 Probab=99.56 E-value=2.1e-19 Score=190.09 Aligned_cols=335 Identities=20% Similarity=0.239 Sum_probs=214.3 Template_Neff=12.300 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++.. ..+.++++ T Consensus 1 ~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~~~~~-g~~i~~~~~~~~~~~~~----~~~~~~~l 65 (346) T 1USG_A 1 DDIKVAVVGAMSGPIA----------QWGDMEFNGARQAIKDINAKGGIK-GDKLVGVEYDDACDPKQ----AVAVANKI 65 (346) T ss_dssp CCEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHHH----HHHHHHHH T ss_pred CCeEEEEEecCCCCch----------hhhHHHHHHHHHHHHHHHHCCCCC-CceEEEEEEcCCCCHHH----HHHHHHHH Confidence 3689999999775321 255678899999999999876543 67788888776655332 23334433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++...+ T Consensus 66 ~~-------------------~~v~~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~-~~~~~~~~~~~~~~~~ 125 (346) T 1USG_A 66 VN-------------------DGIKYVIGHLCSSSTQPASDIYEDEGILMISPGATNPELTQR-GYQHIMRTAGLDSSQG 125 (346) T ss_dssp HH-------------------TTCCEEECCSSHHHHHHHHHHHHHHTCEEEECCCCCGGGGSS-CCSSEEECSCCGGGHH T ss_pred Hh-------------------CCCCEEEcCCCchhhHHHHHHHHHhCCEEEecCCCCHHHHhc-CCCceEEecCChhhhH Confidence 32 478889988776665566677788899999987665544322 3567888888888888 Q NP_000836.2 204 QAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 204 ~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.+++++ ++.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++.. T Consensus 126 ~~~~~~l~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~~ 201 (346) T 1USG_A 126 PTAAKYILETVKPQRIAIIHDKQQYGEGLARSVQDGLKAA-NANVVFFDGIT--AGEKDFSALIARLKK-ENIDFVYYGG 201 (346) T ss_dssp HHHHHHCCCCCCCSSEEEEECSSHHHHHHHHHHHHHHHHT-TCCEEEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEES T ss_pred HHHHHHHHHhhCCCEEEEEEcCCccchhHHHHHHHHHHHC-CCeEeEEeccC--CCCCChHHHHHHHHH-CCCCEEEEec Confidence 8889887 45689999999976667778888888888775 35554322222 122345556666653 5788888776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEF 362 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 362 (908) .+..+..+++++++.|+ ++.|++.+.+...... ........+.+...+.. +...+....|.+. T Consensus 202 ~~~~~~~~~~~~~~~g~--~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~--------------~~~~~~~~~f~~~ 264 (346) T 1USG_A 202 YYPEMGQMLRQARSVGL--KTQFMGPEGVGNASLS-NIAGDAAEGMLVTMPKR--------------YDQDPANQGIVDA 264 (346) T ss_dssp CHHHHHHHHHHHHHTTC--CCEEEECGGGCCTTHH-HHHGGGGTTCEEEECCC--------------GGGSGGGHHHHHH T ss_pred ChHHHHHHHHHHHHcCC--CCeEEcCcccccHHHH-HHHchhhcCcEEEcCCC--------------cCCChhHHHHHHH Confidence 55567788888888877 3567766543322110 00011122222111100 0001111222222 Q NP_000836.2 363 WEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKEL 442 (908) Q Consensus 363 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l 442 (908) +++.+. ..+..++..+|||++++++++++.... +++.+ T Consensus 265 ~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~---------------~~~~i 302 (346) T 1USG_A 265 LKADKK---------------------------DPSGPYVWITYAAVQSLATALERTGSD---------------EPLAL 302 (346) T ss_dssp HHHTTC---------------------------CCCCHHHHHHHHHHHHHHHHHHHHCCC---------------CHHHH T ss_pred HHHhhC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC---------------CHHHH Confidence 222111 112345778999999999999886531 34467 Q NP_000836.2 443 LGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 443 ~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) .+.|++..|.|.+| ++.||++|++. ..+.+++++ T Consensus 303 ~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~ 337 (346) T 1USG_A 303 VKDLKANGANTVIG-PLNWDEKGDLKGFDFGVFQWH 337 (346) T ss_dssp HHHHHHHCEEETTE-EECBCTTSSBSSCCCEEEEEC T ss_pred HHHHHhCCCCccCc-ceeeCCCCCcCcccEEEEEEe Confidence 78888888999999 89999988876 467777776 No 67 >3IP6_A ABC transporter, substrate binding protein; VENUS FLYTRAP DOMAIN, TRANSPORT PROTEIN; 1.4A {Agrobacterium tumefaciens} Probab=99.55 E-value=2.6e-19 Score=190.40 Aligned_cols=349 Identities=15% Similarity=0.188 Sum_probs=218.3 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.++.. ...+.....+++.|++++|+.+++. |+++++.+.|+..++. ...+.++++ T Consensus 1 ~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~~~~~~~~----~~~~~~~~l 65 (356) T 3IP6_A 1 MDVVIAVGAPLTGPN----------AAFGAQIQKGAEQAAKDINAAGGIN-GEQIKIVLGDDVSDPK----QGISVANKF 65 (356) T ss_dssp CCEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHTTCBT-TBCEEEEEEECTTCHH----HHHHHHHHH T ss_pred CcEEEEEEecCCCCC----------hHHHHHHHHHHHHHHHHHHHcCCcC-CceeEEEEecCCCCHH----HHHHHHHHH Confidence 368999999976532 1256678899999999999876543 6778887777655433 223334443 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. ++++++|++.++.....+...+...++|+|.+....+.+... ..++++++.++....+ T Consensus 66 ~~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~~ 125 (356) T 3IP6_A 66 VA-------------------DGVKFVVGHFNSGVSIPASEVYAENGILEITPAATNPVFTER-GLWNTFRTCGRDDQQG 125 (356) T ss_dssp HH-------------------TTCCEEEECSSHHHHHHHHHHHHTTTCEEEESSCCCGGGGSS-CCTTEEESSCCHHHHH T ss_pred HH-------------------CCCCEEEecCCchhhHHHHHHHHHcCCEEEccCCCChhhhcc-CCcCeEEecCChhHHH Confidence 32 478889987766655566677788899999988765543322 2356788888888888 Q NP_000836.2 204 QAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 204 ~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) +.+++++ ++++|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....++++++ .+++++++.. T Consensus 126 ~~~~~~l~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~~ 201 (356) T 3IP6_A 126 GIAGKYLADHFKDAKVAIIHDKTPYGQGLADETKKAANAA-GVTEVMYEGVN--VGDKDFSALISKMKE-AGVSIIYWGG 201 (356) T ss_dssp HHHHHHHHHHCTTCCEEEEECSSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEES T ss_pred HHHHHHHHHhcCCCeEEEEeCCChhhHHHHHHHHHHHHHC-CCeeeEeeccC--CCCCChHHHHHHHHH-hCCCEEEEeC Confidence 8888888 45699999999976667777888888888775 35543322222 122344555666653 4778877776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEF 362 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 362 (908) .+..+..+++++++.|+. ..|++.+.+...... ........+.+..... . +...+....|.+. T Consensus 202 ~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~~~~~~~~~f~~~ 264 (356) T 3IP6_A 202 LHTEAGLIIRQAADQGLK--AKLVSGDGIVSNELA-SIAGDAVEGTLNTFGP-----------D---PTLRPENKELVEK 264 (356) T ss_dssp CHHHHHHHHHHHHHHTCC--CEEEECTTCCSHHHH-HHHGGGGTTCEEEECC-----------C---GGGCGGGHHHHHH T ss_pred chHHHHHHHHHHHHCCCC--CeEEEcccccCHHHH-HHHhHHhcCceeecCC-----------C---cccChhHHHHHHH Confidence 566778888988888774 356665543221110 0001112222211100 0 0001111222222 Q NP_000836.2 363 WEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKEL 442 (908) Q Consensus 363 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l 442 (908) +++ +. ..+..++..+|||++++++++++... .++..+ T Consensus 265 ~~~-~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~~~~~l 301 (356) T 3IP6_A 265 FKA-AG---------------------------FNPEAYTLYSYAAMQAIAGAAKAAGS---------------VEPEKV 301 (356) T ss_dssp HHH-TT---------------------------CCCCTTHHHHHHHHHHHHHHHHHHTC---------------CCHHHH T ss_pred HHH-hC---------------------------CCCChHHHHHHHHHHHHHHHHHHcCC---------------CCHHHH Confidence 221 10 11234567899999999999987642 134567 Q NP_000836.2 443 LGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 443 ~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.|++..|.|.+| .+.||++|++. ..+.+.+++... ++.|+.++.|.. T Consensus 302 ~~~l~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~~~~-~g~~~~~~~~~~ 351 (356) T 3IP6_A 302 AEALKKGSFPTALG-EISFDEKGDPKLPGYVMYEWKKGP-DGKFTYIQQGSH 351 (356) T ss_dssp HHHHTTCCBCCTTS-SBCBCTTSCBCCCCCEEEEEEECT-TSSEEEEEC--- T ss_pred HHHHHcCCCCcCce-eEEECCCCCccCCeEEEEEEEeCC-CCcEEEEecCCC Confidence 78888888999888 89999989875 467787876321 357888887753 No 68 >3IPC_A ABC transporter, substrate binding protein; VENUS FLYTRAP DOMAIN, TRANSPORT PROTEIN; 1.3A {Agrobacterium tumefaciens} Probab=99.55 E-value=2.7e-19 Score=190.15 Aligned_cols=348 Identities=16% Similarity=0.198 Sum_probs=218.0 Template_Neff=12.100 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.++.. ...+.....+++.|++++|+.+++. |+++++.+.|+..++. ...+.+++++ T Consensus 2 ~~~Ig~~~~~~~~~----------~~~~~~~~~~~~~a~~~~n~~~~~~-g~~i~~~~~~~~~~~~----~~~~~~~~l~ 66 (356) T 3IPC_A 2 DVVIAVGAPLTGPN----------AAFGAQIQKGAEQAAKDINAAGGIN-GEQIKIVLGDDVSDPK----QGISVANKFV 66 (356) T ss_dssp CEEEEEEECCSSTT----------HHHHHHHHHHHHHHHHHHHHTTCBT-TBCEEEEEEECTTCHH----HHHHHHHHHH T ss_pred CeEEEEEeCCCCCc----------hHHHHHHHHHHHHHHHHHHHCCCcC-CceeEEEEecCCCCHH----HHHHHHHHHH Confidence 67899999977532 1356778899999999999876543 6778887777655533 2233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|++.++.....+...+...++|+|.+.+..+.+... ..++++++.++....++ T Consensus 67 ~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~ 126 (356) T 3IPC_A 67 A-------------------DGVKFVVGHANSGVSIPASEVYAENGILEITPAATNPVFTER-GLWNTFRTCGRDDQQGG 126 (356) T ss_dssp H-------------------TTCCEEEECSSHHHHHHHHHHHHTTTCEEEESSCCCGGGGSS-CCTTEEESSCCHHHHHH T ss_pred h-------------------CCCCEEEccCCchhhHHHHHHHHHcCCEEEecCCCChhhhcc-CCCCeEEecCChhHHHH Confidence 2 478899988766655566677788899999987655543321 24567888888888888 Q NP_000836.2 205 AMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 205 ~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) .+++++ ++++|++|++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .+++++++... T Consensus 127 ~~~~~l~~~~~~~~v~~l~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~~ 202 (356) T 3IPC_A 127 IAGKYLADHFKDAKVAIIHDKTPYGQGLADETKKAANAA-GVTEVMYEGVN--VGDKDFSALISKMKE-AGVSIIYWGGL 202 (356) T ss_dssp HHHHHHHHHCTTCCEEEEECSSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEESC T ss_pred HHHHHHHHhcCCCEEEEEECCChhhHhHHHHHHHHHHHC-CCeEeEEEccC--CCCcCHHHHHHHHHH-cCCCEEEEeCc Confidence 888887 45699999999966667777888888887765 35544322222 122344556666653 47888777765 Q NP_000836.2 284 EDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFW 363 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (908) +..+..+++++++.|+. ..|++.+.+...... ........+.+..... . +...+....|.+.+ T Consensus 203 ~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~~~~~~~~~f~~~~ 265 (356) T 3IPC_A 203 HTEAGLIIRQAADQGLK--AKLVSGDGIVSNELA-SIAGDAVEGTLNTFGP-----------D---PTLRPENKELVEKF 265 (356) T ss_dssp HHHHHHHHHHHHHHTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEESC-----------C---GGGCGGGHHHHHHH T ss_pred hHHHHHHHHHHHHCCCC--CeEEechhhcCHHHH-HHhhHHhcCceeecCC-----------C---CCCChhHHHHHHHH Confidence 66677889998888874 356665533221110 0001112222211100 0 00001111122222 Q NP_000836.2 364 EENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL 443 (908) Q Consensus 364 ~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l~ 443 (908) ++. . ..+..++..+|||++++++++++... .++..+. T Consensus 266 ~~~-~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~~~~~l~ 302 (356) T 3IPC_A 266 KAA-G---------------------------FNPEAYTLYSYAAMQAIAGAAKAAGS---------------VEPEKVA 302 (356) T ss_dssp HHT-T---------------------------CCCCTTHHHHHHHHHHHHHHHHHHTC---------------CCHHHHH T ss_pred HHc-C---------------------------CCCchHHHHHHHHHHHHHHHHHHcCC---------------CCHHHHH Confidence 110 0 01234567899999999999987642 1345677 Q NP_000836.2 444 GYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 444 ~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) ++|++..|.|.+| ++.||++|++. ..+.+.+++..+ ++.++.++.|+. T Consensus 303 ~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~~~-~g~~~~~~~~~~ 351 (356) T 3IPC_A 303 EALKKGSFPTALG-EISFDEKGDPKLPGYVMYEWKKGP-DGKFTYIQQGSH 351 (356) T ss_dssp HHHTTCCBCCTTS-SBCBCTTSCBCCCCCEEEEEEECT-TSSEEEEEC--- T ss_pred HHHHcCCCCccce-EEEECCCCCccCCeEEEEEEEECC-CccEEEEecCCC Confidence 8888888999888 89999989875 467787886321 357888887764 No 69 >4EYG_B Twin-arginine translocation pathway signal; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: VNL, MSE; 1.86A {Rhodopseudomonas palustris} Probab=99.55 E-value=3.1e-19 Score=190.67 Aligned_cols=356 Identities=16% Similarity=0.187 Sum_probs=222.9 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|.. ..|+++++.+.|+.+++. ...+.++ T Consensus 3 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~---~~g~~v~~~~~d~~~~~~----~~~~~~~ 65 (368) T 4EYG_B 3 AEDTFKVGLIVPMTGGQA----------STGKQIDNAIKLYIKKHGDT---VAGKKIEVILKDDAAIPD----NTKRLAQ 65 (368) T ss_dssp -CCEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHCSE---ETTEEEEEEEEECTTCHH----HHHHHHH T ss_pred CCCcEEEEEEEcCCCCCh----------HHHHHHHHHHHHHHHHhCCc---cCCEEEEEEEEcCCCCch----HHHHHHH Confidence 457899999999876421 25567888999999998851 235677877777655533 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++..+.....+...+...++|+|.+....+.+.. .+++++++.+++.. T Consensus 66 ~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 125 (368) T 4EYG_B 66 ELIV------------------NDKVNVIAGFGITPAALAAAPLATQAKVPEIVMAAGTSIITE--RSPYIVRTSFTLAQ 125 (368) T ss_dssp HHHH------------------TSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCGGGGG--GCTTEEESSCCHHH T ss_pred HHHh------------------cCCcCEEEecCChHHHHHHHHHHHHcCCCEEEcCCCCccccC--CCCcEEEcCCChhh Confidence 4332 157889998876666566667778899999988765543322 24678888898888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 126 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~ 201 (368) T 4EYG_B 126 SSIIIGDWAAKNGIKKVATLTSDYAPGNDALAFFKERFTAG-GGEIVEEIKVP--LANPDFAPFLQRMKD-AKPDAMFVF 201 (368) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--SSSCCCHHHHHHHHH-HCCSEEEEE T ss_pred hHHHHHHHHHHCCCCEEEEEecCChhhHHHHHHHHHHHHhC-CCeeceEEecC--CCCCCcHHHHHHHHH-hCCCEEEEE Confidence 88899999877899999999966667777888888888765 35543322222 122344556666653 578888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) .....+..+++++++.|+.. ++.|++.+.+...... ........+.+...... . ....+....|. T Consensus 202 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 267 (368) T 4EYG_B 202 VPAGQGGNFMKQFAERGLDKSGIKVIGPGDVMDDDLL-NSMGDAALGVVTAHMYS----------A---AHPSAMNKEFV 267 (368) T ss_dssp CCTTCHHHHHHHHHHTTGGGTTCEEEEEGGGGCTTTG-GGCCGGGTTCEEEESCC----------T---TCCCHHHHHHH T ss_pred eccchHHHHHHHHHHcCCCcCCCEEEccccccCHHHH-HHchhhhCCcEEEeccc----------C---CCCCHHHHHHH Confidence 65466778888888888753 3566665533221110 00111122222211100 0 00001111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..+..++..+|||++++++++++.... .+++ T Consensus 268 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~ 306 (368) T 4EYG_B 268 AAYKKEFG---------------------------QRPGFMAVGGYDGIHLVFEALKKTGGK--------------ADGD 306 (368) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC--------------CSHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHH Confidence 22222111 112345778999999999999886421 2345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNEN-GDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~-G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++.+|.|.+| ++.|+++ |++...+.+.+++..++...++.+|.|... T Consensus 307 ~v~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~~~~g~~~~~~vg~~~~~ 360 (368) T 4EYG_B 307 SLIAAMKGMKWESPRG-PISIDPETRDIVQNIYIRKVEKVDGELYNIEFAKFDAV 360 (368) T ss_dssp HHHHHHTTCEEEETTE-EEEECTTTCCEEEEEEEEEEEEETTEEEEEEEEEEEEE T ss_pred HHHHHHhCCCccCCCc-ceEeCCCCCcccceEEEEEEEeeCCeEEEeEEEEecCC Confidence 6778888778999888 8999975 566667888888732223457888888754 No 70 >4EYK_A Twin-arginine translocation pathway signal; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: DHB; 1.9A {Rhodopseudomonas palustris} Probab=99.55 E-value=3.1e-19 Score=190.67 Aligned_cols=356 Identities=16% Similarity=0.187 Sum_probs=222.9 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|.. ..|+++++.+.|+.+++. ...+.++ T Consensus 3 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~---~~g~~v~~~~~d~~~~~~----~~~~~~~ 65 (368) T 4EYK_A 3 AEDTFKVGLIVPMTGGQA----------STGKQIDNAIKLYIKKHGDT---VAGKKIEVILKDDAAIPD----NTKRLAQ 65 (368) T ss_dssp -CCEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHCSE---ETTEEEEEEEEECTTCHH----HHHHHHH T ss_pred CCCcEEEEEEEcCCCCCh----------HHHHHHHHHHHHHHHHhCCc---cCCEEEEEEEEcCCCCch----HHHHHHH Confidence 457899999999876421 25567888999999998851 235677877777655533 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++..+.....+...+...++|+|.+....+.+.. .+++++++.+++.. T Consensus 66 ~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 125 (368) T 4EYK_A 66 ELIV------------------NDKVNVIAGFGITPAALAAAPLATQAKVPEIVMAAGTSIITE--RSPYIVRTSFTLAQ 125 (368) T ss_dssp CCCC------------------CSCCSEEEECCSHHHHHHHHHHHHHHTCCEEESSCCCGGGGG--GCTTEEESSCCHHH T ss_pred HHHh------------------cCCcCEEEecCChHHHHHHHHHHHHcCCCEEEcCCCCccccC--CCCcEEEcCCChhh Confidence 4332 157889998876666566667778899999988765543322 24678888898888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 126 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~ 201 (368) T 4EYK_A 126 SSIIIGDWAAKNGIKKVATLTSDYAPGNDALAFFKERFTAG-GGEIVEEIKVP--LANPDFAPFLQRMKD-AKPDAMFVF 201 (368) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--SSSCCCHHHHHHHHH-HCCSEEEEE T ss_pred hHHHHHHHHHHCCCCEEEEEecCChhhHHHHHHHHHHHHhC-CCeeceEEecC--CCCCCcHHHHHHHHH-hCCCEEEEE Confidence 88899999877899999999966667777888888888765 35543322222 122344556666653 578888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) .....+..+++++++.|+.. ++.|++.+.+...... ........+.+...... . ....+....|. T Consensus 202 ~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 267 (368) T 4EYK_A 202 VPAGQGGNFMKQFAERGLDKSGIKVIGPGDVMDDDLL-NSMGDAALGVVTAHMYS----------A---AHPSAMNKEFV 267 (368) T ss_dssp CCTTCHHHHHHHHHHTTGGGTTCEEEEEGGGGCHHHH-TTCCGGGTTCEEEESCC----------T---TCCCHHHHHHH T ss_pred eccchHHHHHHHHHHcCCCcCCCEEEccccccCHHHH-HHchhhhCCcEEEeccc----------C---CCCCHHHHHHH Confidence 65466778888888888753 3566665533221110 00111122222211100 0 00001111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..+..++..+|||++++++++++.... .+++ T Consensus 268 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~ 306 (368) T 4EYK_A 268 AAYKKEFG---------------------------QRPGFMAVGGYDGIHLVFEALKKTGGK--------------ADGD 306 (368) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC--------------CSHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHH Confidence 22222111 112345778999999999999886421 2345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNEN-GDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~-G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++.+|.|.+| ++.|+++ |++...+.+.+++..++...++.+|.|... T Consensus 307 ~v~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~~~~g~~~~~~vg~~~~~ 360 (368) T 4EYK_A 307 SLIAAMKGMKWESPRG-PISIDPETRDIVQNIYIRKVEKVDGELYNIEFAKFDAV 360 (368) T ss_dssp HHHHHHTTCEEEETTE-EEEECTTTCCEEEEEEEEEEEEETTEEEEEEEEEEEEE T ss_pred HHHHHHhCCCccCCCc-ceEeCCCCCcccceEEEEEEEeeCCeEEEeEEEEecCC Confidence 6778888778999888 8999975 566667888888732223457888888754 No 71 >3HUT_A putative branched-chain amino acid ABC; Extracellular ligand-binding receptor,Transport protein,Receptor or; 1.93A {Rhodospirillum rubrum ATCC 11170} Probab=99.54 E-value=4e-19 Score=189.00 Aligned_cols=350 Identities=17% Similarity=0.219 Sum_probs=215.6 Template_Neff=12.100 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|.++.. ...+.....+++.|++++|+.+++ .|.++++...|+.+++.. ..+.+++ T Consensus 2 ~~~~~Ig~i~~~~~~~----------~~~~~~~~~~~~~a~~~~n~~~~~-~g~~v~~~~~d~~~~~~~----~~~~~~~ 66 (358) T 3HUT_A 2 SLALLLGYELPLTGAN----------AAYGRVFQEAARLQLDRFNAAGGV-GGRPVDILYADSRDDADQ----ARTIARA 66 (358) T ss_dssp -CCEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHTTTB-TTBCEEEEEEECTTCHHH----HHHHHHH T ss_pred CcceEEEEEecCCCCc----------HHHHHHHHHHHHHHHHHHHHcCCC-CCeeeEEEEecCCCCHHH----HHHHHHH Confidence 4678999999976532 124567889999999999987654 367788877776555332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ..+++++|++.++.....+...+...++|+|.++...+.+. ...++++++.++.... T Consensus 67 ~~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~--~~~~~~~~~~~~~~~~ 126 (358) T 3HUT_A 67 FVD------------------DPRVVGVLGDFSSTVSMAAGSIYGKEGMPQLSPTAAHPDYI--KISPWQFRAITTPAFE 126 (358) T ss_dssp HHH------------------CTTEEEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCGGGT--TSCTTEEESSCCGGGH T ss_pred Hhh------------------CCCEEEEEcCCCcHHHHHHHHHHHHhCCCEEccCCCCcchh--ccCCCeeEecCCccch Confidence 332 14788899887766555666777888999998876554332 1246788999998888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .+++++++.. T Consensus 127 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~ 202 (358) T 3HUT_A 127 GPNNAAWMIGDGFTSVAVIGVTTDWGLSSAQAFRKAFELR-GGAVVVNEEVP--PGNRRFDDVIDEIED-EAPQAIYLAM 202 (358) T ss_dssp HHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSEEEEES T ss_pred HHHHHHHHHhCCCCEEEEEEeCChhhHHHHHHHHHHHHHc-CCeEeeEEEeC--CCCCCHHHHHHHHHh-hCCCEEEEeC Confidence 8899999887899999999976667778888888888775 35543322222 122345556666653 4788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEF 362 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 362 (908) .+..+..+++++++.|+. ..+++.+.+...... ........+.+...... . ....+....|.+. T Consensus 203 ~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~~~ 266 (358) T 3HUT_A 203 AYEDAAPFLRALRARGSA--LPVYGSSALYSPKFI-DLGGPAVEGVRLATAFV----------L---GASDPVVVEFVSA 266 (358) T ss_dssp CHHHHHHHHHHHHHTTCC--CCEEECGGGCSHHHH-HHHGGGGTTCEEEESCC----------T---TCCSHHHHHHHHH T ss_pred CHHHHHHHHHHHHHCCCC--CCEEecchhcCHHHH-HhhcHHhCCeEEEEccc----------C---CCCCHHHHHHHHH Confidence 566677888888887773 345554433221110 00011122222111000 0 0000111122222 Q NP_000836.2 363 WEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKEL 442 (908) Q Consensus 363 ~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l 442 (908) +++.++ ..++.++..+|||+++++.++++.... .++..+ T Consensus 267 ~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~~~ 305 (358) T 3HUT_A 267 YETLYG---------------------------AIPTLFAAHGYDAVGIMLAAVGRAGPE--------------VTRESL 305 (358) T ss_dssp HHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHCTT--------------CCHHHH T ss_pred HHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC--------------CCHHHH Confidence 221111 112345678999999999999876431 134567 Q NP_000836.2 443 LGYIRAV-NFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 443 ~~~l~~~-~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.|++. .|.|.+| ++.|++++++ ...+.+++++ +++++.+|.|.. T Consensus 306 ~~~l~~~~~~~g~~G-~~~f~~~~~~~~~~~~~~~~~----~~~~~~~~~~~~ 353 (358) T 3HUT_A 306 RDALAATDRYAGVTG-ITRFDPETRETTKILTRLVVR----EGDFRVIDREGH 353 (358) T ss_dssp HHHHHTCCSEEETTE-EEEECTTTCCEEECCEEEEEE----TTEEEEC----- T ss_pred HHHHHcCCCccCCCe-eEEECCCCCccceeEEEEEEE----CCEEEEecCCCC Confidence 7778765 6899988 8999986543 4566777776 367888888864 No 72 >5KUH_C Glutamate receptor ionotropic, kainate 2; GluK2EM with LY466195, SIGNALING PROTEIN; HET: LY5; 11.6A {Rattus norvegicus} Probab=99.54 E-value=4.1e-19 Score=209.95 Aligned_cols=372 Identities=16% Similarity=0.193 Sum_probs=231.8 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~~ 121 (908) +++++||+++|.++.. .+.....|+++|++++|++++++++..+.+...|+.+ +...+ .+.+. T Consensus 2 ~~~i~Ig~~~p~sg~~------------~g~~~~~~~~~A~~~in~~~g~~~~~~~~~~~~~~~~~~~~~~----~~~~~ 65 (757) T 5KUH_C 2 THVLRFGGIFEYVESG------------PMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA----SKKAC 65 (757) T ss_dssp CEEEEEEEEEEESSSC------------SCCHHHHHHHHHHHHHHHCSSSSSSEEEEEEEEEEETTCHHHH----HHHHH T ss_pred CceEEeEEEeecCCCC------------CCcHHHHHHHHHHHHHHcCcccCCCCeeeeeeEecCCCChHHH----HHHHH Confidence 4689999999998742 3567889999999999998877777888887777654 32211 11111 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. .++++++||+.++..+..++.+++..++|+|++.+.++.+.+ .+++++++.+++.. T Consensus 66 ~~~-------------------~~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~ 124 (757) T 5KUH_C 66 DQL-------------------SLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--KDSFYVSLYPDFSS 124 (757) T ss_dssp HHH-------------------HHCCSCEECCSSHHHHHHHHHHHHHTTCCEEECSCCCCCTTC--CCCSEEEEEECHHH T ss_pred HHH-------------------HcCccEEEcCCChHHHHHHHHHHHHHCCCEEEeecCCCCCCC--CCceEEEccCCHHH Confidence 111 147899999998888888888999999999998876665443 36889999999988 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+.++++++.+++|+++++++ ++.++....+.+.+.+.+. ++++... .++ .+..++...+++++. .++++|++. T Consensus 125 ~~~~l~~~~~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~--~~~~~~~~~l~~l~~-~~~~~vv~~ 198 (757) T 5KUH_C 125 LSRAILDLVQFFKWKTVTVVY-DDSTGLIRLQELIKAPSRY-NLRLKIR-QLP--ADTKDAKPLLKEMKR-GKEFHVIFD 198 (757) T ss_dssp HHHHHHHHHHHTTCSEEEEEE-SSTHHHHHTHHHHTGGGTS-SCEEEEE-ECC--SSGGGCHHHHHHHHH-TTCCEEEEE T ss_pred HHHHHHHHHHHcCCCEEEEEE-eCchHHHHHHHHHhCcccc-CceEEEE-EcC--CCccccHHHHHHHHh-CCCEEEEEE Confidence 899999999888999999999 5556766677777766664 3555432 232 223456667777763 578999888 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) .....+..+++++++.|+.. .+.|+........... . .....+..... +.. .. ...+....+. T Consensus 199 ~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~--~~~~~~~~~~~--------~~~-~~----~~~~~~~~f~ 262 (757) T 5KUH_C 199 CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV-E--PYRYSGVNMTG--------FRI-LN----TENTQVSSII 262 (757) T ss_dssp SCHHHHHHHHHHHHHTTCCSTTCEEEECCTTGGGBCC-T--TTTTSCCEEEE--------EEC-SC----TTSHHHHHHH T ss_pred CCHHHHHHHHHHHHHcCCcCCCeEEEEeccCcccCCc-h--hhcccCcceEE--------EEE-ee----CCChHHHHHH Confidence 77777888999998888754 2345543211110000 0 00001100000 000 00 0011122233 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM-STIDG 439 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~-~~~~~ 439 (908) +.|++.+..... .+... .....+..++..+|||++++++|++++....+.. ..|... ...++ T Consensus 263 ~~~~~~~~~~~~----------~~~~~-----~~~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~--~~~~~~~~~~~~ 325 (757) T 5KUH_C 263 EKWSMERLQAPP----------KPDSG-----LLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSS--LQCNRHKPWRFG 325 (757) T ss_dssp HHHHHHHTTSCC----------CSSSC-----BCTTCCCHHHHHHHHHHHHHHHHHHTCTTCCCCC--CCTTSCCCCTTH T ss_pred HHHHHhhcCCCC----------CCCCC-----CCCCCccHHHHHHHHHHHHHHHHHHhccccCCCc--cccCCCCcchhH Confidence 333322210000 00000 0001234567889999999999999876543211 112111 11244 Q NP_000836.2 440 KELLGYIRAVNFNGSAGTPVTFNENGDAPGR--YDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 440 ~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~--~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ..+.+.|++..|.|.+| ++.||++|++... +.++++. ++.++.||.|.... T Consensus 326 ~~l~~~l~~~~~~g~~G-~i~f~~~~~~~~~~~~~~~~~~----~~~~~~vg~~~~~~ 378 (757) T 5KUH_C 326 TRFMSLIKEAHWEGLTG-RITFNKTNGLRTDFDLDVISLK----EEGLEKIGTWDPAS 378 (757) T ss_dssp HHHHHHHHTCEEEETTE-EEECCTTTSEECCCCEEEEEEE----TTEEEEEEEEETTT T ss_pred HHHHHHHHhcccCCccc-eeEecccCCeeeeeEEEEEEcc----cccceeeEEEECCC Confidence 56778888889999988 8999987777654 4444444 35789999998653 No 73 >4EVQ_A Putative ABC transporter subunit, substrate-binding; Structural Genomics, PSI-Biology, Midwest Center; HET: PHB, MSE, SO4, GOL; 1.4A {Rhodopseudomonas palustris} Probab=99.54 E-value=4.1e-19 Score=190.38 Aligned_cols=352 Identities=16% Similarity=0.137 Sum_probs=219.3 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|..+... ..+.....+++.+++++|. ...|+++++...|+.+++.. ..+ T Consensus 10 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~---~~~g~~v~~~~~d~~~~~~~----~~~ 72 (375) T 4EVQ_A 10 SYAQAGALKVGLLLPYSGTYA----------PLGEAITRGLELYVQSQGG---KLGGRSISFVKVDDESAPPK----ATE 72 (375) T ss_dssp -----CCEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHTTT---EETTEEEEEEEEECTTCHHH----HHH T ss_pred cccCCCcEEEEEEeCCCCCch----------hhhHHHHHHHHHHHHhcCC---CcCCEEEEEEEecCCCChHH----HHH Confidence 446678999999999876421 2456788899999998753 22367788777776554322 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++. .++++++|++.++.....+...+...++|+|.+....+.+......++++++.++ T Consensus 73 ~~~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 134 (375) T 4EVQ_A 73 LTTKLIQ------------------SEKADVLIGTVHSGVAMAMVKIAREDGIPTIVPNAGADIITRAMCAPNVFRTSFA 134 (375) T ss_dssp HHHCCCC------------------CSCCSEEEECSSHHHHHHHHHHHHHHCCCEEESSCCCGGGGTTTCCTTEEESSCC T ss_pred HHHHHHH------------------cCCCCEEEEecCHHHHHHHHHHHHHhCCCEEEcCCCChhhcccccCCCEEEeecC Confidence 3333332 1578999987766655666677788899999887665443322235678888898 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) +...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|++ T Consensus 135 ~~~~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 210 (375) T 4EVQ_A 135 NGQIGRATGDAMIKAGLKKAVTVTWKYAAGEEMVSGFKKSFTAG-KGEVVKDITIA--FPDVEFQSALAEIAS-LKPDCV 210 (375) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSEE T ss_pred hhHHHHHHHHHHHHcCCCeEEEEeeCChHhHHHHHHHHHHHHhC-CCeEeeEEEec--CCCcchHHHHHHHHh-hCCCEE Confidence 88888899999887899999999866667777888888888765 35443322222 122345566677763 478888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) ++...+..+..+++++++.|+. ..+++.+.|..... ........+.+..... .. ....+.... T Consensus 211 i~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~ 273 (375) T 4EVQ_A 211 YAFFSGGGALKFIKDYAAANLG--IPLWGPGFLTDGVE--AAAGPAGDGIKTVLHY----------VS---DLDNAENQA 273 (375) T ss_dssp EEECCTHHHHHHHHHHHHTTCC--CCEEEEGGGTTTTH--HHHGGGGTTCEEEESC----------CT---TCCSHHHHH T ss_pred EEEeecchHHHHHHHHHHCCCC--CCEEeccccchhHH--HHHccccCCcEEEEec----------CC---CCCCHHHHH Confidence 8776566677888988888874 34554432221100 0001112222211110 00 000011112 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+++.++ ..++.++..+||++++++.|++++... ..+ T Consensus 274 f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~-------------~~~ 313 (375) T 4EVQ_A 274 FVKSFEAAYK---------------------------IPPDVFAVQGWDAGQLLDAGVKAVGGD-------------VAK 313 (375) T ss_dssp HHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC-------------TTC T ss_pred HHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC-------------ccc Confidence 2222222111 112356778999999999999987531 123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHW 491 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~ 491 (908) ++.+.+.|++..|.|.+| ++.||++|++...+.+.+++ ++.++.+|.+ T Consensus 314 ~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~----~~~~~~~~~~ 361 (375) T 4EVQ_A 314 RKELNAAMAAASFASPRG-PFKLSAAHNPVQNFYLRELK----GGKSVNLGLA 361 (375) T ss_dssp HHHHHHHHHTCEEEETTE-EEEBCTTSCBCCCEEEEEEE----TTEEEEEEEE T ss_pred HHHHHHHHHcCCCCCCCc-ceEeCCCCCeeeeEEEEEEE----CCeEEEeEEe Confidence 456778888888999999 89999888877778888887 3567777766 No 74 >4EVQ_B Putative ABC transporter subunit, substrate-binding; Structural Genomics, PSI-Biology, Midwest Center; HET: GOL, PHB, SO4; 1.4A {Rhodopseudomonas palustris} Probab=99.54 E-value=4.1e-19 Score=190.38 Aligned_cols=352 Identities=16% Similarity=0.137 Sum_probs=222.2 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|..+... ..+.....+++.+++++|. ...|+++++...|+.+++.. ..+ T Consensus 10 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~---~~~g~~v~~~~~d~~~~~~~----~~~ 72 (375) T 4EVQ_B 10 SYAQAGALKVGLLLPYSGTYA----------PLGEAITRGLELYVQSQGG---KLGGRSISFVKVDDESAPPK----ATE 72 (375) T ss_dssp CHHHHCCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHTTT---EETTEEEEEEEEECTTCHHH----HHH T ss_pred cccCCCcEEEEEEeCCCCCch----------hhhHHHHHHHHHHHHhcCC---CcCCEEEEEEEecCCCChHH----HHH Confidence 446678999999999876421 2456788899999998753 22367788777776554322 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++. .++++++|++.++.....+...+...++|+|.+....+.+......++++++.++ T Consensus 73 ~~~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 134 (375) T 4EVQ_B 73 LTTKLIQ------------------SEKADVLIGTVHSGVAMAMVKIAREDGIPTIVPNAGADIITRAMCAPNVFRTSFA 134 (375) T ss_dssp HHHCCCC------------------CSCCSEEEECSSHHHHHHHHHHHHHHCCCEEESSCCCGGGGTTTCCTTEEESSCC T ss_pred HHHHHHH------------------cCCCCEEEEecCHHHHHHHHHHHHHhCCCEEEcCCCChhhcccccCCCEEEeecC Confidence 3333332 1578999987766655666677788899999887665443322235678888898 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) +...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|++ T Consensus 135 ~~~~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 210 (375) T 4EVQ_B 135 NGQIGRATGDAMIKAGLKKAVTVTWKYAAGEEMVSGFKKSFTAG-KGEVVKDITIA--FPDVEFQSALAEIAS-LKPDCV 210 (375) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSEE T ss_pred hhHHHHHHHHHHHHcCCCeEEEEeeCChHhHHHHHHHHHHHHhC-CCeEeeEEEec--CCCcchHHHHHHHHh-hCCCEE Confidence 88888899999887899999999866667777888888888765 35443322222 122345566677763 478888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) ++...+..+..+++++++.|+. ..+++.+.|..... ........+.+..... .. ....+.... T Consensus 211 i~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~ 273 (375) T 4EVQ_B 211 YAFFSGGGALKFIKDYAAANLG--IPLWGPGFLTDGVE--AAAGPAGDGIKTVLHY----------VS---DLDNAENQA 273 (375) T ss_dssp EEECCTHHHHHHHHHHHHTTCC--CCEEEEGGGTTTTH--HHHGGGGTTCEEEESC----------CT---TCCSHHHHH T ss_pred EEEeecchHHHHHHHHHHCCCC--CCEEeccccchhHH--HHHccccCCcEEEEec----------CC---CCCCHHHHH Confidence 8776566677888988888874 34554432221100 0001112222211110 00 000011112 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+++.++ ..++.++..+||++++++.|++++... ..+ T Consensus 274 f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~-------------~~~ 313 (375) T 4EVQ_B 274 FVKSFEAAYK---------------------------IPPDVFAVQGWDAGQLLDAGVKAVGGD-------------VAK 313 (375) T ss_dssp HHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHTTTC-------------TTC T ss_pred HHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCCC-------------ccc Confidence 2222222111 112356778999999999999987531 123 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHW 491 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~ 491 (908) ++.+.+.|++..|.|.+| ++.||++|++...+.+.+++ ++.++.+|.+ T Consensus 314 ~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~i~~~~----~~~~~~~~~~ 361 (375) T 4EVQ_B 314 RKELNAAMAAASFASPRG-PFKLSAAHNPVQNFYLRELK----GGKSVNLGLA 361 (375) T ss_dssp HHHHHHHHHTCEEEETTE-EEEBCTTSCBCCCEEEEEEE----TTEEEEEEEE T ss_pred HHHHHHHHHcCCCCCCCc-ceEeCCCCCeeeeEEEEEEE----CCeEEEeEEe Confidence 456778888888999999 89999888877778888887 3567777766 No 75 >4N0Q_B Leu/Ile/Val-binding protein homolog 3; structural genomics, NIAID, National Institute; HET: LEU; 2.3A {Brucella melitensis} Probab=99.54 E-value=4.2e-19 Score=188.61 Aligned_cols=336 Identities=17% Similarity=0.229 Sum_probs=214.3 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ..+++||++.|+++... ..+.....+++.|++++|+.+++. |.++++.+.|+.+++.. ..+.+++ T Consensus 8 ~~~~~ig~~~p~sg~~~----------~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~~----~~~~~~~ 72 (354) T 4N0Q_B 8 HADITIGVIAPLTGPVA----------AFGDQVKKGAETAVEVINKAGGIK-GEKVVLKFADDAGEPKQ----GVSAANQ 72 (354) T ss_dssp -CCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHHH----HHHHHHH T ss_pred ccCeEEEEEEcCCCCcH----------HHHHHHHHHHHHHHHHHHHccCCC-CeeEEEEEecCCCCHHH----HHHHHHH Confidence 35789999999987642 366788999999999999876543 67888888887665432 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++... T Consensus 73 l~~-------------------~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~ 132 (354) T 4N0Q_B 73 IVG-------------------DGIKFVVGLVTTGVAVPVSDVLSENGVLMVTPTATGPDLTAR-GLENVFRTCGRDGQQ 132 (354) T ss_dssp HHH-------------------TTCCEEEECCSHHHHHHHHHHHHHTTCEEEESSCCCGGGGSS-CCSSEEESSCCHHHH T ss_pred HHh-------------------CCCCEEEEcCCcccHHHHHHHHHHcCCEEEecccCCcchhhc-CCCceeecCCChHHH Confidence 332 478899987766655566677788899999987655443321 256788999998888 Q NP_000836.2 203 AQAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) ++.+++++ ++++|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 133 ~~~~~~~l~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~vi~~ 208 (354) T 4N0Q_B 133 AEVMADYVLKNMKDKKVAVIHDKGAYGKGLADAFKAAINKG-GITEVHYDSVT--PGDKDFSALVTKLKS-AGAEVVYFG 208 (354) T ss_dssp HHHHHHHHHHHCTTSCEEEEECSSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCSEEEEE T ss_pred HHHHHHHHHHhcCCCEEEEEECCCHhhHHHHHHHHHHHHhC-CCeeeEEEeeC--CCCCChHHHHHHHHH-CCCCEEEEe Confidence 99999988 45689999999976667777888888888775 45544322222 122344555666653 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ..+..+..+++++++.|+. +.|++.+.|...... ........+....... . . ...+.+.+ T Consensus 209 ~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~---~~~~~~~~ 268 (354) T 4N0Q_B 209 GYHAEGGLLSRQLHDAGMQ--ALVLGGEGLSNTEYW-AIGGTNAQGTLFTNAK-----------D---A---TKNPAAKD 268 (354) T ss_dssp SCHHHHHHHHHHHHHTTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEEEC-----------C---G---GGSGGGHH T ss_pred cCchhHHHHHHHHHHcCCC--cEEEeccccCCHHHH-HhhcccccCcEEecCC-----------c---c---CCCHHHHH Confidence 6566677888888888773 466665544322110 0001111222111100 0 0 01111222 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) +.++ +.. .. ..++.++..+|||++++++|++++... .+++. T Consensus 269 f~~~-~~~-~~-----------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~~ 309 (354) T 4N0Q_B 269 AIQA-LKA-KN-----------------------IPAEAFTMNAYAAVEVIKAGIERAGST--------------DDSAA 309 (354) T ss_dssp HHHH-HHH-TT-----------------------CCCCHHHHHHHHHHHHHHHHHHHHTCS--------------SCHHH T ss_pred HHHH-HHH-cC-----------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHHH Confidence 2221 110 00 112356778999999999999886431 13445 Q NP_000836.2 442 LLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 442 l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) +.++|++ ..|.|.+| .+.|+++|++. ..+.+++++ T Consensus 310 ~~~~l~~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~ 346 (354) T 4N0Q_B 310 VAKALHDGKPIETAIG-TLTYSETGDLSSPSFDIFKWD 346 (354) T ss_dssp HHHHHTSSCCEEETTE-EECBCTTSCBSSCCEEEEEEE T ss_pred HHHHHhcCCCCcccee-EEEeCCCCCCCCCeeEEEEEE Confidence 7777865 57899988 89999888875 356777776 No 76 >4N0Q_C Leu/Ile/Val-binding protein homolog 3; structural genomics, NIAID, National Institute; HET: LEU; 2.3A {Brucella melitensis} Probab=99.54 E-value=4.2e-19 Score=188.61 Aligned_cols=336 Identities=17% Similarity=0.229 Sum_probs=213.8 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ..+++||++.|+++... ..+.....+++.|++++|+.+++. |.++++.+.|+.+++.. ..+.+++ T Consensus 8 ~~~~~ig~~~p~sg~~~----------~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~~----~~~~~~~ 72 (354) T 4N0Q_C 8 HADITIGVIAPLTGPVA----------AFGDQVKKGAETAVEVINKAGGIK-GEKVVLKFADDAGEPKQ----GVSAANQ 72 (354) T ss_dssp --CEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCSS-SCCEEEEEEECTTCHHH----HHHHHHH T ss_pred ccCeEEEEEEcCCCCcH----------HHHHHHHHHHHHHHHHHHHccCCC-CeeEEEEEecCCCCHHH----HHHHHHH Confidence 35789999999987642 366788999999999999876543 67888888887665432 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++... T Consensus 73 l~~-------------------~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~ 132 (354) T 4N0Q_C 73 IVG-------------------DGIKFVVGLVTTGVAVPVSDVLSENGVLMVTPTATGPDLTAR-GLENVFRTCGRDGQQ 132 (354) T ss_dssp HHH-------------------TTCCEEEECCSHHHHHHHHHHHHHTTCEEEESSCCCGGGSSS-CCSSEEESSCCHHHH T ss_pred HHh-------------------CCCCEEEEcCCcccHHHHHHHHHHcCCEEEecccCCcchhhc-CCCceeecCCChHHH Confidence 332 478899987766655566677788899999987655443321 256788999998888 Q NP_000836.2 203 AQAMVDIV-TALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l-~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) ++.+++++ ++++|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++. T Consensus 133 ~~~~~~~l~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~vi~~ 208 (354) T 4N0Q_C 133 AEVMADYVLKNMKDKKVAVIHDKGAYGKGLADAFKAAINKG-GITEVHYDSVT--PGDKDFSALVTKLKS-AGAEVVYFG 208 (354) T ss_dssp HHHHHHHHHHHCTTSCEEEEECSSHHHHHHHHHHHHHHHHH-TCCCSEEEECC--TTCCCCHHHHHHHHH-TTCSEEEEE T ss_pred HHHHHHHHHHhcCCCEEEEEECCCHhhHHHHHHHHHHHHhC-CCeeeEEEeeC--CCCCChHHHHHHHHH-CCCCEEEEe Confidence 99999988 45689999999976667777888888888775 45544322222 122344555666653 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ..+..+..+++++++.|+. +.|++.+.|...... ........+....... . . ...+.+.+ T Consensus 209 ~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~---~---~~~~~~~~ 268 (354) T 4N0Q_C 209 GYHAEGGLLSRQLHDAGMQ--ALVLGGEGLSNTEYW-AIGGTNAQGTLFTNAK-----------D---A---TKNPAAKD 268 (354) T ss_dssp SCHHHHHHHHHHHHHTTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEEEC-----------C---S---TTSGGGHH T ss_pred cCchhHHHHHHHHHHcCCC--cEEEeccccCCHHHH-HhhcccccCcEEecCC-----------c---c---CCCHHHHH Confidence 6566677888888888773 466665544322110 0001111222111100 0 0 01111222 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) +.++ +.. .. ..++.++..+|||++++++|++++... .+++. T Consensus 269 f~~~-~~~-~~-----------------------~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~~~ 309 (354) T 4N0Q_C 269 AIQA-LKA-KN-----------------------IPAEAFTMNAYAAVEVIKAGIERAGST--------------DDSAA 309 (354) T ss_dssp HHHH-HHH-TT-----------------------CCCCHHHHHHHHHHHHHHHHHHHHTCS--------------SCHHH T ss_pred HHHH-HHH-cC-----------------------CCCChHHHHHHHHHHHHHHHHHHhCCC--------------CCHHH Confidence 2221 110 00 112356778999999999999886431 13445 Q NP_000836.2 442 LLGYIRA-VNFNGSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 442 l~~~l~~-~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) +.++|++ ..|.|.+| .+.|+++|++. ..+.+++++ T Consensus 310 ~~~~l~~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~ 346 (354) T 4N0Q_C 310 VAKALHDGKPIETAIG-TLTYSETGDLSSPSFDIFKWD 346 (354) T ss_dssp HHHHHHSCCCEEETTE-EECBCTTSCBSSCCEEEEEEE T ss_pred HHHHHhcCCCCcccee-EEEeCCCCCCCCCeeEEEEEE Confidence 7777865 57899988 89999888875 356777776 No 77 >3SAJ_C Glutamate receptor 1; Rossmann fold, ion channel, membrane; HET: BMA, MAN, NAG; 2.5A {Rattus norvegicus} Probab=99.54 E-value=4.5e-19 Score=190.74 Aligned_cols=357 Identities=17% Similarity=0.268 Sum_probs=218.4 Template_Neff=11.900 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++ .....|+++|++++|+++++++++++ +...|+.. ..+.+ T Consensus 6 ~~~~~i~Ig~~~~~~~----------------~~~~~~~~~a~~~~n~~~~~~~~~~~-~~~~d~~~--------~~~~~ 60 (384) T 3SAJ_C 6 AMPNNIQIGGLFPNQQ----------------SQEHAAFRFALSQLTEPPKLLPQIDI-VNISDSFE--------MTYRF 60 (384) T ss_pred cCCCCEEEEEEcCCCc----------------HHHHHHHHHHHHHHHHcCCCCCCEEE-EEEcCcHH--------HHHHH Confidence 4567899999999875 24668999999999987766555555 44444321 11122 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. ++++++||+.++..+..++..+...++|+|++.+.... ..++++. .+++ T Consensus 61 ~~~~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~-----~~~~~~~-~~~~- 114 (384) T 3SAJ_C 61 CSQFS-------------------KGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDT-----SNQFVLQ-LRPE- 114 (384) T ss_pred HHHHh-------------------cCCCEEECCCCHHHHHHHHHHHHHhCCCEEeCCCCCCC-----CCCccee-cCHH- Confidence 22221 47889999888877777788889999999998754321 1233333 4333 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+.++++++++++|++|++++ ++.++....+.+++.+++. ++++.....++ .+..++...+++++. .++|+|++ T Consensus 115 -~~~~~~~~~~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 188 (384) T 3SAJ_C 115 -LQEALISIIDHYKWQTFVYIY-DADRGLSVLQRVLDTAAEK-NWQVTAVNILT--TTEEGYRMLFQDLEK-KKERLVVV 188 (384) T ss_pred -HHHHHHHHHHHhCCCEEEEEe-cChhhHHHHHHHHHHHHHc-CCeEEEEEecC--CCCCCcHHHHHHHHH-hCCCEEEE Confidence 678888888888999999999 6677877788888887775 35554433332 122456666777763 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSD-SWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~-~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) .........+++++++.|+.. .+.|+..+ .|..... ........+...... + . ...+.... T Consensus 189 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~~~~~----------~-~----~~~~~~~~ 251 (384) T 3SAJ_C 189 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDL--NKFKESGANVTGFQL----------V-N----YTDTIPAR 251 (384) T ss_pred eCCHHHHHHHHHHHHHCCCCCCCeEEEEeCCCcCCCch--HHhhhcccccceeEe----------e-C----CCCcccHH Confidence 877777788999998888753 46677654 2322110 000000111111000 0 0 00111122 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM 434 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~ 434 (908) +.+.|++.+.. .|.... ...+..++..+|||++++++++++.....+.. ....|... T Consensus 252 f~~~~~~~~~~-------------~~~~~~------~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~~~c~~~ 312 (384) T 3SAJ_C 252 IMQQWRTSDSR-------------DHTRVD------WKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLAN 312 (384) T ss_pred HHHHHHHHHCC-------------CCCCCC------CCCCChHHHHHHHHHHHHHHHHHHHHhcCCCCCCCCCCCccCCC Confidence 33333333221 010000 01234567889999999999999987543210 01122211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ ++.++.||.|+... T Consensus 313 ~~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 372 (384) T 3SAJ_C 313 PAVPWGQGIDIQRALQQVRFEGLTG-NVQFNEKGRRTNYTLHVIEMK----HDGIRKIGYWNEDD 372 (384) T ss_pred CCCCccCHHHHHHHHhcCCcccCCc-cEEEcCCCCCCCeeEEEEEee----CCcEEEeEEEeCCC Confidence 0114456778888889999998 899999998753 56666665 35789999998653 No 78 >6E7R_B Glutamate receptor ionotropic, NMDA 1; NMDA Receptor, Ion channel, Allosteric; HET: HYS, CL, MAN, NAG, BMA; 2.1A {Xenopus laevis} Probab=99.53 E-value=6e-19 Score=188.06 Aligned_cols=348 Identities=15% Similarity=0.202 Sum_probs=223.3 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.. ....|++.|++++|+.++++ |.++++... +.+++.. ..+.+.++ T Consensus 2 ~~i~ig~~~~~~------------------~~~~~~~~a~~~in~~~~~~-g~~i~l~~~-~~~~~~~----~~~~~~~l 57 (363) T 6E7R_B 2 PSIGIAVILVGT------------------SDEVAIKDAHEKDDFHHLSV-VPRVELVAM-NETDPKS----IITRICDL 57 (363) T ss_dssp CEEEEEEEEESS------------------CCHHHHHHHTTGGGGCCSSS-EEEEEEEEE-CCCSHHH----HHHHHHHH T ss_pred CceeEEEEEeCC------------------chhHHHHHHHHhcCCCCCcc-CCcEEEEEc-CCCCHHH----HHHHHHHH Confidence 578999998621 35678999999999877654 567777666 4444332 22333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVI--GAAASSV-SIMVANILRLFKIPQISYASTA-PELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vI--g~~~s~~-~~~va~~~~~~~iP~Is~~~~~-~~l~~~~~~~~~~~~~~~~ 199 (908) +. .++++++| |+.++.. +..+...+...++|+|++.+.. ..+++...+++++++.+++ T Consensus 58 ~~------------------~~~v~~vi~~g~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 119 (363) T 6E7R_B 58 MS------------------DRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSI 119 (363) T ss_dssp HH------------------HSCEEEEEEEESSCCTHHHHHHHHHHHHHTCCEEEEEGGGGSCCCSCCTTCCEEESSCCH T ss_pred Hh------------------hCCceEEEEcCCCCHHHHHHHHHHHHHhhCCCEEEecCCCcccccCCCccceeEEcCCCH Confidence 32 14789999 8877753 6677778888999999887643 2333333578999999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~vi 278 (908) ...++++++++.+++|+++++++.+++++....+.+++.+++. ++++.....++.... ..++...+++++. .++++| T Consensus 120 ~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~~v 197 (363) T 6E7R_B 120 EQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS-FVGWELEEVLLLDMSLDDGDSKIQNQLKK-LQSPII 197 (363) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSTTHHHHHHHHHHHHHTS-SSCCEEEEEEECCTTSCCTTCHHHHHHTT-CCCSEE T ss_pred HHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHhhc-CCCeEEEEEEEecCCCCCchHHHHHHHHh-CCCCEE Confidence 9899999999988899999999987778887888888877765 355543222211011 2245566777763 578988 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++......+..+++++++.|+.. ++.|+..+.+...... . ......+.+.+ T Consensus 198 v~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~-~~~~~~g~~~~-------------------------- 249 (363) T 6E7R_B 198 LLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDT-V-PSEFPTGLISV-------------------------- 249 (363) T ss_dssp EEESCHHHHHHHHHHHHHTTCSSTTCEEEECHHHHCSTTC-C-CTTSCTTCEEE-------------------------- T ss_pred EEeCCHHHHHHHHHHHHHcCCCCCCeEEEeecCCCCCCCC-C-CccCCCceEEE-------------------------- Confidence 88877777788899888888753 4567665422211000 0 00000110000 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIGLCPRM- 434 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~~~~~~- 434 (908) .+ . .+ ...++..+|||++++++|++++....+.. ....|... T Consensus 250 ~~----~-~~------------------------------~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~c~~~~ 294 (363) T 6E7R_B 250 SY----D-EW------------------------------DYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTH 294 (363) T ss_dssp EC----S-SS------------------------------SSCHHHHHHHHHHHHHHHHHHHHHHHSCCCCCCSCSTTTT T ss_pred ee----c-cc------------------------------ccChhHHHHHHHHHHHHHHHHHHhhcCCCCCCCccccCCC Confidence 00 0 00 01235678999999999999987532110 01122211 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.++|++..|.| | ++.|+++|++. ..+.|++++. ...++.||.|+... ++...+.|+ T Consensus 295 ~~~~~~~~~l~~~l~~~~~~g--g-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 361 (363) T 6E7R_B 295 EKRIYQSNMLNRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNK---ERKWERVGKWKDKS-LQMKYYVWP 361 (363) T ss_dssp GGGGGCCCTTHHHHTSCEETT--E-ECCBCTTSBBSSCCEEEEEECT---TSCEEEEEEEETTE-EEESCSSCC T ss_pred cccchhhHHHHHHHcceEecC--e-eeeeCCCCccccceEEEEEeeC---CCceEEEEEEECCe-eEeeceecC Confidence 1124556778888888987 7 89999999875 5788888873 25688999998762 333346663 No 79 >6E7S_D Glutamate receptor ionotropic, NMDA 1; NMDA Receptor, Ion channel, Allosteric; HET: MAN, HZ4, NAG, BMA; 2.72A {Xenopus laevis} Probab=99.53 E-value=6e-19 Score=188.06 Aligned_cols=348 Identities=15% Similarity=0.202 Sum_probs=223.3 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.. ....|++.|++++|+.++++ |.++++... +.+++.. ..+.+.++ T Consensus 2 ~~i~ig~~~~~~------------------~~~~~~~~a~~~in~~~~~~-g~~i~l~~~-~~~~~~~----~~~~~~~l 57 (363) T 6E7S_D 2 PSIGIAVILVGT------------------SDEVAIKDAHEKDDFHHLSV-VPRVELVAM-NETDPKS----IITRICDL 57 (363) T ss_dssp CEEEEEEEEESS------------------CCHHHHHHHHTTTTTCCSSC-EEEEEEEEE-SCCSHHH----HHHHHHHH T ss_pred CceeEEEEEeCC------------------chhHHHHHHHHhcCCCCCcc-CCcEEEEEc-CCCCHHH----HHHHHHHH Confidence 578999998621 35678999999999877654 567777666 4444332 22333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVI--GAAASSV-SIMVANILRLFKIPQISYASTA-PELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vI--g~~~s~~-~~~va~~~~~~~iP~Is~~~~~-~~l~~~~~~~~~~~~~~~~ 199 (908) +. .++++++| |+.++.. +..+...+...++|+|++.+.. ..+++...+++++++.+++ T Consensus 58 ~~------------------~~~v~~vi~~g~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 119 (363) T 6E7S_D 58 MS------------------DRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSI 119 (363) T ss_dssp HH------------------HSCEEEEEEECSSCCTHHHHHHHHHHHHHTCCEEEEEGGGGSCCCSCCTTCCEEESSCCH T ss_pred Hh------------------hCCceEEEEcCCCCHHHHHHHHHHHHHhhCCCEEEecCCCcccccCCCccceeEEcCCCH Confidence 32 14789999 8877753 6677778888999999887643 2333333578999999999 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~vi 278 (908) ...++++++++.+++|+++++++.+++++....+.+++.+++. ++++.....++.... ..++...+++++. .++++| T Consensus 120 ~~~~~~~~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~~v 197 (363) T 6E7S_D 120 EQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS-FVGWELEEVLLLDMSLDDGDSKIQNQLKK-LQSPII 197 (363) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSTTHHHHHHHHHHHHHSC-SSCCEEEEEEECCTTSCCTTCHHHHHHTT-CCCSEE T ss_pred HHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHhhc-CCCeEEEEEEEecCCCCCchHHHHHHHHh-CCCCEE Confidence 9899999999988899999999987778887888888877765 355543222211011 2245566777763 578988 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++......+..+++++++.|+.. ++.|+..+.+...... . ......+.+.+ T Consensus 198 v~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~-~~~~~~g~~~~-------------------------- 249 (363) T 6E7S_D 198 LLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDT-V-PSEFPTGLISV-------------------------- 249 (363) T ss_dssp EEESCHHHHHHHHHHHHHTTCSSTTCEEEECHHHHCSTTC-C-CTTSCTTCEEE-------------------------- T ss_pred EEeCCHHHHHHHHHHHHHcCCCCCCeEEEeecCCCCCCCC-C-CccCCCceEEE-------------------------- Confidence 88877777788899888888753 4567665422211000 0 00000110000 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIGLCPRM- 434 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~~~~~~- 434 (908) .+ . .+ ...++..+|||++++++|++++....+.. ....|... T Consensus 250 ~~----~-~~------------------------------~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~c~~~~ 294 (363) T 6E7S_D 250 SY----D-EW------------------------------DYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTH 294 (363) T ss_dssp EC----T-TS------------------------------SSCHHHHHHHHHHHHHHHHHHHHHHHSCCCCCCSCSTTTT T ss_pred ee----c-cc------------------------------ccChhHHHHHHHHHHHHHHHHHHhhcCCCCCCCccccCCC Confidence 00 0 00 01235678999999999999987532110 01122211 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.++|++..|.| | ++.|+++|++. ..+.|++++. ...++.||.|+... ++...+.|+ T Consensus 295 ~~~~~~~~~l~~~l~~~~~~g--g-~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 361 (363) T 6E7S_D 295 EKRIYQSNMLNRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNK---ERKWERVGKWKDKS-LQMKYYVWP 361 (363) T ss_dssp TTTTTCCSTTHHHHTSCEETT--E-ECCBCTTSBBSSCCEEEEEECT---TSCEEEEEEEETTE-EEESCSSCC T ss_pred cccchhhHHHHHHHcceEecC--e-eeeeCCCCccccceEEEEEeeC---CCceEEEEEEECCe-eEeeceecC Confidence 1124556778888888987 7 89999999875 5788888873 25688999998762 333346663 No 80 >3HSY_B Glutamate receptor 2; GLUTAMATE RECEPTOR, LIGAND-GATED ION CHANNEL; HET: BMA, NAG, SO4; 1.75A {Rattus norvegicus} Probab=99.53 E-value=6.1e-19 Score=188.94 Aligned_cols=357 Identities=15% Similarity=0.172 Sum_probs=218.5 Template_Neff=12.200 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|+++|++++|+. |+++++.+ .|+.+++.. +.+.+.+ T Consensus 1 ~~i~Ig~~~~~~~~----------------~~~~~~~~a~~~~n~~-----g~~i~~~~~~~~~~~~~~----~~~~~~~ 55 (376) T 3HSY_B 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCS 55 (376) T ss_dssp CEEEEEEEEETTCH----------------HHHHHHHHHHHHHCCS-----SCEEEEEEEEECTTCHHH----HHHHHHH T ss_pred CceeEEEEecCCCh----------------HHHHHHHHHHHHhcCC-----CceeceeEEecCCCChHH----HHHHHHH Confidence 36899999998752 4678999999999975 35677765 344444332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. ++++++||+.++.....++.+++..++|+|++..... ..+++++++.|+ . T Consensus 56 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~p~---~ 108 (376) T 3HSY_B 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---L 108 (376) T ss_dssp HHH-------------------HTCSEEEECCCTTTHHHHHHHHHHHTCEEEECSCCCS-----SCCTTEEECSCC---C T ss_pred HHh-------------------cCeeEEEecCChHHHHHHHHHHhhcCCeEEecCCCCC-----CCCCcEEEecCC---H Confidence 332 4788999998887777888889999999998764332 246889999887 3 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++++++++.+++|+++++++.++ ++....+.+.+.+++. ++++......+.. .+..++...+++++. .++++|++ T Consensus 109 ~~~~~~~l~~~~~~~v~il~~~~-~~~~~~~~~~~~~~~~-~~~v~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vv~ 185 (376) T 3HSY_B 109 KGALLSLIEYYQWDKFAYLYDSD-RGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (376) T ss_dssp HHHHHHHHHHTTCCEEEEEECTT-TCSHHHHHHHHHHHHH-TCEEEEEEGGGTTSTTHHHHHHHHHCCCCC-SCCCEEEE T ss_pred HHHHHHHHHHhCCCEEEEEEeCc-chHHHHHHHHHHHhhc-CceEEEEEeecCCCCCCccchHHHHHHccc-cCCcEEEE Confidence 67778888888999999999665 7777777777777664 3555432221100 112345666777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+.......+++++++.|+.. .+.|+..+........ ........+...+... . ...+....| T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f 249 (376) T 3HSY_B 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV-----------D----YDDSLVSKF 249 (376) T ss_dssp CSCGGGHHHHHHHHHHHSSSGGGCEEEECSSBGGGSCC-CTTTTTTCEEEEEESS-----------C----TTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCCcCCeEEEEecCCCCcccH-HHhccCCeeEEEEEEe-----------c----CCChHHHHH Confidence 877777888999998888753 3456655321111000 0000001111111000 0 001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~- 434 (908) .+.+++.+..... .. ....+..++..+|||++++++|++++....+.. ....|... T Consensus 250 ~~~~~~~~~~~~~----------~~---------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~ 310 (376) T 3HSY_B 250 IERWSTLEEKEYP----------GA---------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (376) T ss_dssp HHHHTTSCTTTST----------TC---------SSSCCCHHHHHHHHHHHHHHHHHTTSCCCCCCCCCCCCTTHHHHSC T ss_pred HHHHHccChhhCC----------CC---------CCCCCChHHHHHHHHHHHHHHHHHHHHhcccccccCCCCCccCCCC Confidence 3333322211000 00 001234567889999999999999876432110 00122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ .+.++.+|.|.... T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 369 (376) T 3HSY_B 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEVD 369 (376) T ss_dssp CCCHHHHHHHHHHHHTCCEEETTE-EECBCTTSCBCSCEEEEEEEE----TTEEEEEEEEETTT T ss_pred CCCchhhHHHHHHHhcCCcccCCe-eEEECCCCceeeeEEEEEEee----cCCcEEEEEEeCCC Confidence 0124556778888889999988 899999898875 88888887 25688999998653 No 81 >3SAJ_B Glutamate receptor 1; Rossmann fold, ion channel, membrane; HET: MAN, BMA, NAG; 2.5A {Rattus norvegicus} Probab=99.53 E-value=6.5e-19 Score=189.48 Aligned_cols=357 Identities=17% Similarity=0.268 Sum_probs=217.5 Template_Neff=11.900 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++ .....|+++|++++|+++++++++++ +...|+.. ..+.+ T Consensus 6 ~~~~~i~ig~~~p~~~----------------~~~~~~~~~a~~~~n~~~~~~~~~~~-~~~~d~~~--------~~~~~ 60 (384) T 3SAJ_B 6 AMPNNIQIGGLFPNQQ----------------SQEHAAFRFALSQLTEPPKLLPQIDI-VNISDSFE--------MTYRF 60 (384) T ss_dssp CCCSEEEEEEEESSSS----------------CHHHHHHHHHHHTCCSSSEEEEEEEE-CCTTCHHH--------HHHHH T ss_pred CCCCceeEEEEeCCCC----------------hHHHHHHHHHHHHccCCCccCCccEE-ecCCcHHH--------HHHHH Confidence 4567899999999875 24668999999999987766655555 44444321 11122 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+++. ++++++||+.++..+..++..+...++|+|++.+.... ..++++. .+++ T Consensus 61 ~~~~~-------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~-----~~~~~~~-~~~~- 114 (384) T 3SAJ_B 61 CSQFS-------------------KGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDT-----SNQFVLQ-LRPE- 114 (384) T ss_dssp HHHHH-------------------HTCSCEEECCCTTTHHHHHHHHHHHTCCEEECSCCCSS-----CCTTEEE-CSCC- T ss_pred HHhhh-------------------cCeEEEEecCCHHHHHHHHHHHhhcCCcEEeCCCCCCC-----CCceEEE-echh- Confidence 22221 47889999888877777788889999999998754321 1233333 3333 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .+.++++++++++|++|++++ ++.++....+.+++.+++. ++++.....++ .+..++...+++++. .++|+|++ T Consensus 115 -~~~~~~~~~~~~~~~~v~vi~-~~~~~~~~~~~~~~~~~~~-~~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~iv~ 188 (384) T 3SAJ_B 115 -LQEALISIIDHYKWQTFVYIY-DADRGLSVLQRVLDTAAEK-NWQVTAVNILT--TTEEGYRMLFQDLEK-KKERLVVV 188 (384) T ss_dssp -CHHHHHHHHHHHTCCEEEEEE-CHHHHTTHHHHHHHHHHHH-TCEEEEEETTT--CCHHHHHHHHHHHHH-SSSCEEEE T ss_pred -HHHHHHHHHHHcCCCEEEEEE-cCccchHHHHHHHHHHHhc-CCceEEEEecc--CCccchHHHHHHHhh-cCCcEEEE Confidence 678888888888999999999 6677877788888877765 35554433232 122355666777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSD-SWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~-~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) .........+++++++.|+.. .+.|+..+ .|..... ........+...... + . ...+.... T Consensus 189 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~~~~~----------~-~----~~~~~~~~ 251 (384) T 3SAJ_B 189 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDL--NKFKESGANVTGFQL----------V-N----YTDTIPAR 251 (384) T ss_dssp ECCHHHHHHHHHHHHHTTCSSTTCEEEEECSBTTSSCC--SSSTTTSCEEEEEEC----------C-C----TTSHHHHH T ss_pred ECCHHHHHHHHHHHHHhccccCCeEEEEeeCCccccCH--HHHhccCCceEEEEE----------E-c----CCCchHHH Confidence 877777788999998888753 46677654 2322110 000000111111000 0 0 00111222 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM 434 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~ 434 (908) +.+.|++.+.. .|.... ...+..++..+|||++++++++++.....+.. ....|... T Consensus 252 f~~~~~~~~~~-------------~~~~~~------~~~~~~~~~~~ydav~~~~~al~~~~~~~~~~~~~~~~~~c~~~ 312 (384) T 3SAJ_B 252 IMQQWRTSDSR-------------DHTRVD------WKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLAN 312 (384) T ss_dssp HHHHHHHHHHH-------------C------------CCCCHHHHHHHHHHHHHHHHHHHHHHHTCCCCCCCSCCCSCCB T ss_pred HHHHHHccCcc-------------CCCCCC------CCCCcchHHHHHHHHHHHHHHHHHHHHCCCCchhcCCCCCcccC Confidence 33333333221 010000 01234567789999999999999887543210 01122211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.||++|++.. .+.+++++ ++.++.||.|+... T Consensus 313 ~~~~~~~~~~l~~~l~~~~f~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 372 (384) T 3SAJ_B 313 PAVPWGQGIDIQRALQQVRFEGLTG-NVQFNEKGRRTNYTLHVIEMK----HDGIRKIGYWNEDD 372 (384) T ss_dssp SCCCCTTHHHHHHHHHTCEEEETTE-EEEBCTTSBBCSCCEEEEEEE----TTEEEEEEEEETTT T ss_pred CCCCcccHHHHHHHHhcCCccCCcc-eEEECCCCCeeeeEEEEEEee----eCceEEeEEEcCCC Confidence 0114456778888888999988 899999888753 56666665 35789999998653 No 82 >3N6V_D Glutamate receptor 2; AMPA, assembly, NTD, GluR2, GluA2; 3.2A {Rattus norvegicus} Probab=99.52 E-value=6.9e-19 Score=188.37 Aligned_cols=355 Identities=15% Similarity=0.178 Sum_probs=216.7 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ++||+++|.++. ....|+++|++++|+. |.++++.+ .|+.+++.. ..+.+++++ T Consensus 1 i~ig~~~~~~g~----------------~~~~~~~~a~~~in~~-----g~~l~~~~~~~~~~~~~~----~~~~~~~l~ 55 (374) T 3N6V_D 1 IQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCSQF 55 (374) T ss_dssp CEEEEEEETTCH----------------HHHHHHHHHHHHHCCS-----SCCCEEEEEEECTTCHHH----HHHHHHHHH T ss_pred CceeeeeCCCCH----------------HHHHHHHHHHHHhhCC-----CceeceeEEecCCCChHH----HHHHHHHHH Confidence 578999988752 4678999999999975 35667665 455444332 222333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++||+.++.....++.++...+||+|++..... ..+++++++.|+ .+. T Consensus 56 ~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~~~ 108 (374) T 3N6V_D 56 S-------------------RGVYAIFGFYDKKSVNAITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---LKG 108 (374) T ss_dssp H-------------------HTCSEEEECCCTTTHHHHHHHHHHHTCEEEECSCCCS-----SCCSSEEECSCC---HHH T ss_pred h-------------------cCeeEEEecCChHHHHHHHHHHHhcCCceeeCCCCCC-----CCCCcEEEecCC---HHH Confidence 2 4788999998887777778889999999998764321 246889999887 367 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++++++.+++|+++++++.++ ++....+.+.+.+++. ++++......+.. .+..++...+++++. .++++|++.+ T Consensus 109 ~~~~~~~~~~~~~v~iv~~~~-~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vv~~~ 185 (374) T 3N6V_D 109 ALLSLIEYYQWDKFAYLYDSD-RGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVILDC 185 (374) T ss_dssp HHHHHHHHTTCCEEEEEECGG-GCSHHHHHHHHHHHHT-TCEEEEEECTTCCSTTHHHHHHTTSTTTTT-TTCCEEEEES T ss_pred HHHHHHHHhCCcEEEEEEeCC-cchhhHHHHHHHHHhc-CCeEEEEEeccCCCCCCccchHHHHHHHcc-cCCcEEEEEC Confidence 778888788999999999655 7777777777777664 3555432221100 112356666777763 5789988887 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ....+..+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|.+ T Consensus 186 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~~ 249 (374) T 3N6V_D 186 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV-----------D----YDDSLVSKFIE 249 (374) T ss_dssp CHHHHHHHHHHHHHTTCSSTTCEEEECSSBSSSSCC-GGGTTTSCEEEEEESS-----------C----TTSHHHHHHHH T ss_pred CHHHHHHHHHHHHHcCCccCceEEEEecCCCCcccH-hHhhcCCeeEEEEEEE-----------c----CCChHHHHHHH Confidence 7777888999998888753 3456655321111000 0000011111111100 0 00111122333 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM--- 434 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~--- 434 (908) .|++.+..... .. ....+..++..+||+++++++|++++....+.. ....|... T Consensus 250 ~~~~~~~~~~~-------------~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~~~ 310 (374) T 3N6V_D 250 RWSTLEEKEYP-------------GA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAV 310 (374) T ss_dssp HHTTSCTTTST-------------TC------SSSCCCHHHHHHHHHHHHHHHHHHTTTTTTCCCCC----CCTTCSSCC T ss_pred HHHcCChhhCC-------------CC------CCCccchhHHHHHHHHHHHHHHHHHHHhcccccccCCCCCCccCCCCC Confidence 33322211000 00 001234567789999999999999886432110 00122110 Q NP_000836.2 435 STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ .+.++.+|.|+... T Consensus 311 ~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 367 (374) T 3N6V_D 311 PWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEVD 367 (374) T ss_dssp CCTTHHHHHHHHHTCEEEETTE-EEEBCTTSCBCSCEEEEEEEC----SSCEEEEEEEETTT T ss_pred CccchHHHHHHHhcCccccCCe-eEEECCCCCeeeeEEEEEEee----cCCcEEEEEEeCCC Confidence 0124556778888888999988 899999998875 78888887 24788999998653 No 83 >4GNR_A ABC transporter substrate-binding protein-branched chain; amino acid-binding protein, surface-exposed protein; 1.0A {Streptococcus pneumoniae} Probab=99.52 E-value=7e-19 Score=186.67 Aligned_cols=347 Identities=15% Similarity=0.192 Sum_probs=213.1 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++... ..+.....+++.|++++|+.+++ .++++++...|+.+++.. ..+.+ T Consensus 3 ~~~~~~~Ig~~~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~~~~-~~~~~~~~~~d~~~~~~~----~~~~~ 67 (353) T 4GNR_A 3 VEEKTIKIGFNFEESGSLA----------AYGTAEQKGAQLAVDEINAAGGI-DGKQIEVVDKDNKSETAE----AASVT 67 (353) T ss_dssp ---CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCB-TTBEEEEEEEECTTCHHH----HHHHH T ss_pred ccCceEEEEEEecCCCCch----------HHcHHHHHHHHHHHHHHHHCCCC-CCcceEEEEecCCCChHH----HHHHH Confidence 3457899999999876421 35667888999999999987654 357788877777655432 33333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++++++||+.++.....+...+...++|+|.+....+.+.. ..++++++.++.. T Consensus 68 ~~l~~------------------~~~v~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 127 (353) T 4GNR_A 68 TNLVT------------------QSKVSAVVGPATSGATAAAVANATKAGVPLISPSATQDGLTK--GQDYLFIGTFQDS 127 (353) T ss_dssp HHHHH------------------TSCCSEEECCCSHHHHHHHHHHHHHTTCCEEESSCCCTTTTT--TCTTEEECSCCHH T ss_pred HHHHh------------------cCCeeEEECCCChHHHHHHHHHHHHhCCCEEecCCCCCcCcC--CCCceeEecCChH Confidence 33332 147899998877766667777888899999998765544332 2467788888888 Q NP_000836.2 201 YQAQAMVDIVT-ALGWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~-~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++++++++. +++|+++++++.+ +.++....+.+.+... ..+.....+. .+..+....++++++ .+++++ T Consensus 128 ~~~~~~~~~l~~~~~~~~v~i~~~~~~~~~~~~~~~~~~~~~----~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 200 (353) T 4GNR_A 128 FQGKIISNYVSEKLNAKKVVLYTDNASDYAKGIAKSFRESYK----GEIVADETFV--AGDTDFQAALTKMKG-KDFDAI 200 (353) T ss_dssp HHHHHHHHHHHHTSCCSEEEEEEETTCHHHHHHHHHHHHHCC----SEEEEEEEEC--TTCCCCHHHHHHHHT-SCCSEE T ss_pred HHHHHHHHHHHHHcCCCEEEEEEcCcchHHHHHHHHHHHHcC----CceeeEEEec--CCCCCHHHHHHHhhc-CCCCEE Confidence 88888898885 5789999998855 4555555555554322 2222211121 122345566777763 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) ++......+..+++++++.|+. ..|++.+.+...............+.+...... .. ....+.... T Consensus 201 i~~~~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~--~~~~~~~~~ 266 (353) T 4GNR_A 201 VVPGYYNEAGKIVNQARGMGID--KPIVGGDGFNGEEFVQQATAEKASNIYFISGFS----------TT--VEVSAKAKA 266 (353) T ss_dssp ECCSCHHHHHHHHHHHHHTTCC--SCEEECGGGCSHHHHHHHCTTTCCSEEEEESCC----------SS--SSCCHHHHH T ss_pred EEcCCHHHHHHHHHHHHHCCCC--CCEEeccccccHHHHHHhchhhhcCEEEEeccc----------CC--cccCHHHHH Confidence 7776666778888888888773 456665543321110000001111211111000 00 000011112 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+.+.++ ..++.++..+||+++++++++++... T Consensus 267 f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~----------------- 302 (353) T 4GNR_A 267 FLDAYRAKYN---------------------------EEPSTFAALAYDSVHLVANAAKGAKN----------------- 302 (353) T ss_dssp HHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHTTCSS----------------- T ss_pred HHHHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHhcCCC----------------- Confidence 2222222111 11235678899999999999987531 Q NP_000836.2 439 GKELLGYIRA-VNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 439 ~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ++.+.+.|++ ..|.|.+| ++.|+++|++...+.+.+++ ++.++.+|.|+ T Consensus 303 ~~~~~~~l~~~~~~~g~~G-~~~f~~~~~~~~~~~v~~~~----~~~~~~~~~~~ 352 (353) T 4GNR_A 303 SGEIKDNLAKTKDFEGVTG-QTSFDADHNTVKTAYMMTMN----NGKVEAAEVVK 352 (353) T ss_dssp HHHHHHHHHTCCCEEETTE-EECCCTTSCCCCCEEEEEEE----TTEEEEEEEEC T ss_pred hHHHHHHHhcCCCCCCCcc-eeEEcCCCCccceEEEEEEE----CCEEEEeeeeC Confidence 2346677766 47889988 89999988887778888776 35788888885 No 84 >3N0X_A Possible substrate binding protein of; Receptor family ligand binding region; HET: GOL; 1.5A {Rhodopseudomonas palustris} Probab=99.52 E-value=7.4e-19 Score=188.33 Aligned_cols=348 Identities=14% Similarity=0.174 Sum_probs=214.4 Template_Neff=11.600 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++... ..+.....|++.|++++|+.++.++|.++++.+.|+++++..+ .+.+++ T Consensus 2 ~~~i~Ig~~~~~~g~~~----------~~~~~~~~g~~~a~~~~n~~g~~~~g~~i~~~~~d~~~~~~~~----~~~~~~ 67 (374) T 3N0X_A 2 ADDLKIALIYGKTGPLE----------AYAKQTETGLMMGLEYATKGTMTLDGRKIVVITKDDQSKPDLS----KAALAE 67 (374) T ss_dssp --CEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHTTTCCEETTEEEEEEEEECTTCHHHH----HHHHHH T ss_pred CCceEEEEEeCCCCCch----------HHHHHHHHHHHHHHHHhhcCCCccCCeEEEEEEecCCCChHHH----HHHHHH Confidence 46799999999887431 3566788999999999998554355788999988887765433 333344 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++.+ +++++++|+.++.....++..+...++|++...+.++.+.+...+++++++.++.... T Consensus 68 l~~~------------------~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (374) T 3N0X_A 68 AYQD------------------DGADIAIGTSSSAAALADLPVAEENKKILIVEPAVADQITGEKWNRYIFRTGRNSSQD 129 (374) T ss_dssp HHHT------------------SCCSEEEECSSHHHHHHHHHHHHHHTCCEEECSCCCGGGGTTTCCTTEEECSCCHHHH T ss_pred HHhh------------------cCCCEEEecCCcHHHHhHHHHHHHcCCEEEeCCCCchHHhCCCCCccEEEccCCchhH Confidence 3321 5788999988777777788888889999998776555443322467889999988888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET----PNARAV 278 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~----~~~~vi 278 (908) +.++++++.+ .|++|++++.++.++....+.+++.+++. ++++.....+. .+..++...+++++.. .++++| T Consensus 130 ~~~~~~~~~~-~~~~v~iv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~i~~~~~~~~~~~~v 205 (374) T 3N0X_A 130 AISNAVAIGK-QGVTIATLAQDYAFGRDGVAAFKEALAKT-GATLATEEYVP--TTTTDFTAVGQRLFDALKDKPGKKII 205 (374) T ss_dssp HHHHHHHHCC-TTEEEEEEEESSHHHHHHHHHHHHHHTTT-TCEEEEEEEEC--TTCCCCHHHHHHHHHHHTTCSSEEEE T ss_pred HHHHHHHHHh-cCCEEEEEecCcHHHHHHHHHHHHHHHHc-CCeeceeeecC--CCCCChHHHHHHHHHHhcCCCCCCeE Confidence 8888887765 67899999977778888888888888765 45654433332 2233455566666521 145666 Q NP_000836.2 279 IMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++.. .......++++++..++. ..|+..+.+.... ... ....+........ .. ....+... T Consensus 206 ~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~---~~~-~~~~~~~~~~~~~---------~~---~~~~~~~~ 267 (374) T 3N0X_A 206 WVIWAGGGDPLTKLQDMDPKRYG--IELSTGGNILPAL---AAY-KRLPGMEGATYYY---------YD---IPKNPINE 267 (374) T ss_dssp EECCCSSSCHHHHHHHTCGGGGT--EEEEECCCCTTGG---GGG-GGSTTCEEEESCC---------TT---SCCSHHHH T ss_pred EEEEecCCcHHHHHHhccccccC--ceeccccchHHHH---HHH-hhCCCceeeeecc---------cc---CCCChhhH Confidence 5533 344455666666665542 2344332221100 000 0011111100000 00 00011122 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) .|.+.+++.++ ..++.++..+|||+++++.|++++.. . T Consensus 268 ~f~~~~~~~~~---------------------------~~p~~~~~~~yda~~~~~~al~~~~~---------------~ 305 (374) T 3N0X_A 268 WLVTEHQKRFN---------------------------APPDFFTAGGFSAAMAVVTAVQKAKS---------------T 305 (374) T ss_dssp HHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------C T ss_pred HHHHHHHHHHC---------------------------CCCChhHHHHHHHHHHHHHHHHHcCC---------------C Confidence 23332322221 11235678899999999999988642 1 Q NP_000836.2 438 DGKELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 438 ~~~~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++..+.++|++..|+|.+| ++.|++ ++++...+.+++++.. + +|.|+.. T Consensus 306 ~~~~i~~~l~~~~~~g~~G-~i~f~~~~~~~~~~~~i~~~~~~---~----~~~w~~~ 355 (374) T 3N0X_A 306 DTEKLIAAMEGMEFDTPKG-KMVFRKEDHQALQSMYHFKVKVD---P----AVAWAVL 355 (374) T ss_dssp CHHHHHHHHTTCEEEETTE-EEEECTTTCBEECCEEEEEEECC---T----TSSSCEE T ss_pred CHHHHHHHHcCCceecCCe-eEEeCCCCCeeeeeeEEEEEcCC---h----hhhcccc Confidence 3456778888888999888 899987 5555567777776621 1 5677654 No 85 >6KSP_B Glutamate receptor ionotropic, delta-1; complex, membrane protein; 8.1A {Rattus norvegicus} Probab=99.52 E-value=7.5e-19 Score=210.74 Aligned_cols=372 Identities=15% Similarity=0.185 Sum_probs=225.3 Template_Neff=11.500 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|+++|++++|+++++++|+++++++.| +++++..+ .+.+++ T Consensus 2 ~~i~Ig~l~p~sg~----------------~~~~g~~~a~~~in~~~g~~~~~~i~~~~~d~~~~~~~~~----~~~~~~ 61 (856) T 6KSP_B 2 SIIHIGAIFEENAA----------------KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQA----VQEACD 61 (856) T ss_dssp CCCBCCEEECSCCH----------------HHHHHHHHHHHHHHSSCSSSTTCCCBCCEEECCSSCCHHH----HHHHHH T ss_pred ceeeeeeeeccccc----------------CchHHHHHHHHHHhcCcccccccceeEEeEeccCCCHHHH----HHHHHH Confidence 57999999998752 5678999999999998877767899999888 55554332 233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS-- 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~-- 200 (908) ++. ++++++||+.++..+.+++..+...++|+|++ +..+.+.. .++++++..+++. T Consensus 62 l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~-~~~~~~~~--~~~~~~~~~~~~~~~ 119 (856) T 6KSP_B 62 LMT-------------------QGILALVTSTGCASANALQSLTDAMHIPHLFV-QRNPGGSP--RTACHLNPSPDGEAY 119 (856) T ss_dssp HTT-------------------TCCSCCCCBCCSTTSHHHHHHHHTTTCCEEEC-CCCTTSCC--CCCCCCCSCCTTTCC T ss_pred Hhh-------------------cCeeEEecCCCchhHHHHHHHHHhcCCCEEEe-ecCCCCCC--CcccccccCCCCCce Confidence 332 57899999988887778888899999999998 44443332 3455666655554 Q NP_000836.2 201 --------YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR---E---PRPGEFEKII 266 (908) Q Consensus 201 --------~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~---~---~~~~~~~~~~ 266 (908) .++.++++++++++|+++++++ +++++....+.+.+.+++. ++++.....++. + ....+....+ T Consensus 120 ~~~~~p~~~~~~~l~~~~~~~~~~~v~il~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~l 197 (856) T 6KSP_B 120 TLASRPPVRLNDVMLRLVTELRWQKFVMFY-DSEYDIRGLQSFLDQASRL-GLDVSLQKVDKNISHVFTSLFTTMKTEEL 197 (856) T ss_dssp EEECSCCCCHHHHHHHHHHHHTCCSCEEEE-CTTCCGGGGTTHHHHHHHT-TCCCEEEECCSCHHHHHHHHHHHCCHHHH T ss_pred eeecCCCccHHHHHHHHHHHcCCcEEEEEE-eCCchHHHHHHHHHHHHhh-CCeEEEEEccCChhHhcHHHHhhhcHHHH Confidence 7788888888888999999999 6667777777777777664 355433222110 0 0122334556 Q NP_000836.2 267 KRLLETPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYF 345 (908) Q Consensus 267 ~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~ 345 (908) +++++ . .+.+++.+....+..+++++++.|+.. .+.|+..+.+...............+....... T Consensus 198 ~~~~~-~-~~~vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------- 264 (856) T 6KSP_B 198 NRYRD-T-LRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQI----------- 264 (856) T ss_dssp HHHHH-H-HTEEEECSCHHHHHHHHHHHHHTTCCCTTCEEEECCSCCCHHHHHHHHHHCSSBCEEEECC----------- T ss_pred Hhchh-h-cceEEEEcChHHHHHHHHHHHHcCCCCCCceEEEEcCCCCChhHHHHHhhhcccceEEehh----------- Confidence 66653 3 344444455667888899998888753 356666543322111000000011111111000 Q NP_000836.2 346 RSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP 425 (908) Q Consensus 346 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~ 425 (908) . ...+....|.+.+++.+.+. |..... ....+..++..+|||++++++|++++....+. T Consensus 265 ~----~~~~~~~~f~~~~~~~~~~~-------------~~~~~~----~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~ 323 (856) T 6KSP_B 265 F----PSAKDNQKCMRNNHRISSLL-------------CDPQEG----YLQMLQISNLYLYDSVLMLANAFHRKLEDRKW 323 (856) T ss_dssp C----CCSCCSSTTBCSSCBCCSST-------------TTTCTT----TSTTCCHHHHHHHHHHHHHHHHHHHHHTTTCC T ss_pred c----CCcchhHHHHhhcccccccc-------------cCCCcc----ccccccHHHHHHHHHHHHHHHHHHHHHHcCCc Confidence 0 00111222333333332210 000000 00123456788999999999999987643211 Q NP_000836.2 426 G--YIGLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITN-KSTEYKVIGHWTNQ 494 (908) Q Consensus 426 ~--~~~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~-~~~~~~~Vg~~~~~ 494 (908) . ....|... ...++..+.++|++..|.|.+| ++.||++|++. ..+.+++++..+ ....+..||.|... T Consensus 324 ~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~~~~~~~~~~~~v~~~~~~ 398 (856) T 6KSP_B 324 HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTG-VMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSE 398 (856) T ss_dssp CCCCSCCSSSSCCCCCSTTHHHHHHHHTCCCCSSSS-CCCCCTTCBCCCCEEEEEECCCBTTTBCCCCCCEEEETT T ss_pred ccccccccccCCCCCccCchhHHHHHHhCceeeeee-eEEecCCCCCceEEEEEEeeccCCcCCcceEEEEEEeCC Confidence 0 01112110 1124567888888889999998 89999999875 578888887431 12367889999864 No 86 >3N6V_B Glutamate receptor 2; AMPA, assembly, NTD, GluR2, GluA2; 3.2A {Rattus norvegicus} Probab=99.52 E-value=8.3e-19 Score=187.76 Aligned_cols=355 Identities=15% Similarity=0.178 Sum_probs=216.6 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI-LDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~-~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ++||+++|.++. ....|+++|++++|+. |.++++.+ .|+.+++.. ..+.+++++ T Consensus 1 i~ig~~~~~~g~----------------~~~~~~~~a~~~in~~-----g~~l~~~~~~~~~~~~~~----~~~~~~~l~ 55 (374) T 3N6V_B 1 IQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCSQF 55 (374) T ss_pred CeEEEEccCCCH----------------HHHHHHHHHHHHHHHC-----CCEEEEEEEeCCCCCHHH----HHHHHHHHH Confidence 578999988752 4678999999999975 35667665 455444332 222333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++||+.++.....++.++...+||+|++..... ..+++++++.|+ .+. T Consensus 56 ~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~~~ 108 (374) T 3N6V_B 56 S-------------------RGVYAIFGFYDKKSVNAITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---LKG 108 (374) T ss_pred h-------------------cCCCEEECCCChHHHHHHHHHHHhhCCCEECCCcCCC-----ccCCceeecCHH---HHH Confidence 2 4788999998887777778888999999998764321 246889999887 367 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~--~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++++++.+++|++++++++++ ++....+.+.+.+++. ++++......+.. .+..++...+++++. .++++|++.+ T Consensus 109 ~~~~~~~~~~~~~v~iv~~~~-~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vv~~~ 185 (374) T 3N6V_B 109 ALLSLIEYYQWDKFAYLYDSD-RGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVILDC 185 (374) T ss_pred HHHHHHHHhCCCeEEEEEeCc-hhHHHHHHHHHHHHHC-CCEEEEEEeeCCCCCCCCCCHHHHHHHHHH-cCCCEEEEeC Confidence 778888788999999999655 7777777777777664 3555432221100 122356666777763 5789988887 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ....+..+++++++.|+.. .+.|+..+........ ........+...+... . ...+....|.+ T Consensus 186 ~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~-----------~----~~~~~~~~f~~ 249 (374) T 3N6V_B 186 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV-----------D----YDDSLVSKFIE 249 (374) T ss_pred CHHHHHHHHHHHHHcCCCCCCcEEEEecCCCCCCch-HHhhccccceeeeeec-----------C----CCCHHHHHHHH Confidence 7777888999998888753 3456655321111000 0000011111111100 0 00111122333 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG----YIGLCPRM--- 434 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~----~~~~~~~~--- 434 (908) .|++.+..... .. ....+..++..+||+++++++|++++....+.. ....|... T Consensus 250 ~~~~~~~~~~~-------------~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~c~~~~~~ 310 (374) T 3N6V_B 250 RWSTLEEKEYP-------------GA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAV 310 (374) T ss_pred HHHHHhCCCCC-------------CC------CCCCCccHHHHHHHHHHHHHHHHHHHhhcCCcccCCCCCCccCCCCCC Confidence 33322211000 00 001234567789999999999999886432110 00122110 Q NP_000836.2 435 STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQL 495 (908) Q Consensus 435 ~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~~ 495 (908) ...++..+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ .+.++.+|.|.... T Consensus 311 ~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~vg~w~~~~ 367 (374) T 3N6V_B 311 PWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEVD 367 (374) T ss_pred CCCCHHHHHHHHHcCcccCCCc-ceEeCCCCCcCCCeEEEEEEe----CCceEEeEEEeCCC Confidence 0124556778888889999988 899999998875 78888887 24788999998653 No 87 >1Z17_A Leu/Ile/Val-binding protein; periplasmic binding proteins, alpha-beta fold; 1.96A {Escherichia coli} Probab=99.52 E-value=8.4e-19 Score=185.21 Aligned_cols=333 Identities=20% Similarity=0.234 Sum_probs=211.1 Template_Neff=12.300 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++. ...+.+++++ T Consensus 2 ~~~Ig~~~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~----~~~~~~~~l~ 66 (344) T 1Z17_A 2 DIKVAVVGAMSGPVA----------QYGDQEFTGAEQAVADINAKGGIK-GNKLQIVKYDDACDPK----QAVAVANKVV 66 (344) T ss_dssp CEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHH----HHHHHHHHHH T ss_pred CeEEEEEecCCCchH----------HhhHHHHHHHHHHHHHHHHCCCcC-CceEEEEEEcCCCCHH----HHHHHHHHHH Confidence 689999999875321 245678899999999999876543 6778888777665532 2223333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|++.++.....+...+...++|+|.+....+.+... .+++++++.+++...+. T Consensus 67 ~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~ 126 (344) T 1Z17_A 67 N-------------------DGIKYVIGHLCSSSTQPASDIYEDEGILMITPAATAPELTAR-GYQLILRTTGLDSDQGP 126 (344) T ss_dssp H-------------------TTCCEEEECCSHHHHHHHHHHHHHHTCEEEESSCCCGGGGSS-CCSSEEESSCCHHHHHH T ss_pred h-------------------cCCCEEEcCCCCcchHHHHHHHHHHCCeEEecCCCCHHHHhc-CCCeEEEecCCcccchH Confidence 2 478899988766655566677788899999987655443221 24677888888888888 Q NP_000836.2 205 AMVDIVT-ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 205 ~~~~~l~-~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) .+++++. +.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .+++++++... T Consensus 127 ~~~~~l~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~~ 202 (344) T 1Z17_A 127 TAAKYILEKVKPQRIAIVHDKQQYGEGLARAVQDGLKKG-NANVVFFDGIT--AGEKDFSTLVARLKK-ENIDFVYYGGY 202 (344) T ss_dssp HHHHHCCCCCCCSSEEEEECSSHHHHHHHHHHHHHHHHT-TCCEEEEEECC--TTCCCCHHHHHHHHH-TTCCEEEEESC T ss_pred HHHHHHHHHcCCCEEEEEEcCCchhHHHHHHHHHHHHhC-CCEEeEEeccC--CCCCChHHHHHHHHH-CCCCEEEEecC Confidence 8888884 4589999999976667777788888887765 35543322222 122345556666653 47888877765 Q NP_000836.2 284 EDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFW 363 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (908) +..+..+++++++.|+ ++.|++.+.+...... ........+.+...+.. ....+....|.+.+ T Consensus 203 ~~~~~~~~~~~~~~g~--~~~~i~~~~~~~~~~~-~~~~~~~~g~~~~~~~~--------------~~~~~~~~~f~~~~ 265 (344) T 1Z17_A 203 HPEMGQILRQARAAGL--KTQFMGPEGVANVSLS-NIAGESAEGLLVTKPKN--------------YDQVPANKPIVDAI 265 (344) T ss_dssp HHHHHHHHHHHHHTTC--CCEEEECGGGCSHHHH-HHHGGGGTTCEEEECCC--------------GGGSGGGHHHHHHH T ss_pred chHHHHHHHHHHHcCC--CcEEEcCCcccCHHHH-HHhhhhcCCeEEEcCCC--------------CCCCcchHHHHHHH Confidence 6667788899888887 3567766543322110 00111122322211100 00001111222222 Q NP_000836.2 364 EENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL 443 (908) Q Consensus 364 ~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l~ 443 (908) ++.++ ..++.++..+|||++++++++++.. ++..+. T Consensus 266 ~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~-----------------~~~~l~ 301 (344) T 1Z17_A 266 KAKKQ---------------------------DPSGAFVWTTYAALQSLQAGLNQSD-----------------DPAEIA 301 (344) T ss_dssp HTTTC---------------------------CCCSHHHHHHHHHHHHHHHHHTTCS-----------------CHHHHH T ss_pred HHHHC---------------------------CCCChHHHHHHHHHHHHHHHHhcCC-----------------CHHHHH Confidence 22111 1123457789999999999987631 234577 Q NP_000836.2 444 GYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQI 478 (908) Q Consensus 444 ~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~ 478 (908) ++|++..|.|.+| ++.|+++|++. ..+.+.+++. T Consensus 302 ~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~ 336 (344) T 1Z17_A 302 KYLKANSVDTVMG-PLTWDEKGDLKGFEFGVFDWHA 336 (344) T ss_dssp HHHHHSCEEETTE-EECBCTTSCBTTCCCEEEEECT T ss_pred HHHHhCCCCcCce-eeEeCCCCCcCcceEEEEEEec Confidence 7788888999998 89999989876 5777887773 No 88 >4RU0_B Putative branched-chain amino acid ABC; ABC transporter permease, Structural Genomics; HET: MSE, GOL, P3G; 2.442A {Pseudomonas protegens Pf-5} Probab=99.51 E-value=1e-18 Score=192.27 Aligned_cols=370 Identities=12% Similarity=0.111 Sum_probs=225.6 Template_Neff=11.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINK-DPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~-~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++++||++.|.++... ..+.....|++.|++++|+ .+++. |+++++.+.|+++++.. ..+ T Consensus 28 ~~~~~~~~ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~g~~~-g~~v~~~~~d~~~~~~~----~~~ 92 (447) T 4RU0_B 28 QAGPDQQFFPLATYRVGAYA----------SSGVQVWAGMIDYLNYINQVEGGIN-GVKLVWQECETEWTAEK----GIE 92 (447) T ss_dssp --CTTSEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCSBT-TBCEEEEEEECTTCHHH----HHH T ss_pred hcCCCceEEEEeeccCCCcc----------ccchhHHHHHHHHHHHHHHhcCCcC-CeEeEEEEEcCCCCHHH----HHH Confidence 34567899999999875421 2566788999999999997 55443 67788887777655332 333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++.+ ..+.+++++++.++.....+...+...++|+|.+.+..+.+.+....++++++.++ T Consensus 93 ~~~~l~~~----------------~~~~~~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 156 (447) T 4RU0_B 93 CYERFKNG----------------LDGAPVAVYQPNGAPAAYALSERAEVDKIPLITLGYGRTEATDGTVFPYNFPVMLT 156 (447) T ss_dssp HHHHHTTC----------------BTTBCBSCBCCCSHHHHHHHHHHHHHTTCCEECTTCSCGGGGCTTTCTTEECCSCC T ss_pred HHHHHHhc----------------CCCCCEEEEcCCCcHHHHHHHHHHHHcCCCEEEcCCCchhhcCCCCCCccccccCC Confidence 34443320 00367788888777666677778888999999987765543321235678899999 Q NP_000836.2 199 DSYQAQAMVDIVTA-------LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 199 ~~~~~~~~~~~l~~-------~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) +...++.+++++.+ .+|++|++++.++.++..+.+.+++.+++. ++++... .+. ....+....+++++. T Consensus 157 ~~~~~~~~~~~~~~~~~~~~~~~~~~i~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~-~~~--~~~~~~~~~~~~~~~ 232 (447) T 4RU0_B 157 FYSEASTLVNYIAQREGGFDRLKGKKIATLYHDSAYGRETLGPLKLLAEKY-GFENIQI-PVA--DPGNEQSAQWRQIRQ 232 (447) T ss_dssp HHHHHHHHHHHHHHHHTSGGGGTTCEEEEEEESSHHHHTTHHHHHHHHHHH-CCEEEEE-EEC--TTCCCCHHHHHHHHH T ss_pred hHHHHHHHHHHHHHhcCCccccCCCEEEEEecCChHhHhcHHHHHHHHHHh-CCEEEEE-EeC--CCCCchHHHHHHHHH Confidence 88888899998865 689999999966667777888888888775 4555431 121 122345566666663 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .++|++++...+..+..+++++++.|+.. .++..+.|...............+.+...... .. . T Consensus 233 -~~~~~i~~~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~---~ 296 (447) T 4RU0_B 233 -QNPDWVFLRTWGVSTPVAVKTAARFGFPV--DHIIGDIWASSSEDVLPAGAAAKGYLALTPYP----------AG---S 296 (447) T ss_dssp -HCCSEEEEECCTTHHHHHHHHHHHTTCCG--GGEEECGGGCSGGGTGGGGGGGTTCEEEESSC----------CC---S T ss_pred -hCCCEEEEEcCCccHHHHHHHHHHcCCCC--cEEEeeccCCCchhhHhhHHhhCCeEEeecCC----------CC---C Confidence 57888887765666778889988888753 23333323221100000111122222211100 00 0 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLC 431 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~ 431 (908) ..+....|.+.+++.+...+.. ....++.++..+|||+++++++++++...... T Consensus 297 ~~~~~~~f~~~~~~~~~~~~~~--------------------~~~~~~~~~~~~yda~~~~~~al~~~~~~~g~------ 350 (447) T 4RU0_B 297 DFEIHKRLKQYILDTGKSDLKD--------------------LKNFGSVYYNSGLVNAAVAVEAIRTAQGKFGK------ 350 (447) T ss_dssp CSTTHHHHCCCCCTTTCCSCSC--------------------GGGTTSHHHHHHHHHHHHHHHHHHHHHHHHCS------ T ss_pred CCHHHHHHHHHHHHhCCCcccc--------------------ccccCChhHHHHHHHHHHHHHHHHHHHHhcCC------ Confidence 0011112222222211100000 00112456788999999999999987532100 Q NP_000836.2 432 PRMSTIDGKELLGYIRAVNF----------NGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 432 ~~~~~~~~~~l~~~l~~~~f----------~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...++..+.+.|++..+ .|.+| ++.|+++|++. ..+.+++++ ++.++.++.|... T Consensus 351 ---~~~~~~~l~~~l~~~~~~~~~~~~~~~~G~~G-~i~f~~~~~~~~~~~~i~~~~----~g~~~~v~~~~~~ 416 (447) T 4RU0_B 351 ---RPLNGEEGRWGLEHLNIDDARLKDMGYLGLMQ-NLKLSCRDHEGGGAARVQQWD----GANWTLISEWIAA 416 (447) T ss_dssp ---SCCCHHHHHHHHHTCEECHHHHHHHTCTTTSC-CEECCSSCSCCCCEEEEEEEC----SSCEEECCCCEEC T ss_pred ---CCCChHHHHHHHHhccCCchHHhccCcccccc-CeeecCCCCcccceEEEEEEe----CCeEEEcceeEec Confidence 01245567777777666 67888 89999888764 467788886 3578899988754 No 89 >5EWM_D NMDA glutamate receptor subunit, Glutamate; Glutamate receptor, allosteric modulator, GluN2B; HET: MAN, 5SM, NAG, BMA; 2.76A {Xenopus laevis} Probab=99.51 E-value=1e-18 Score=186.31 Aligned_cols=349 Identities=15% Similarity=0.211 Sum_probs=214.9 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++ ...|+++|++++|+.++.. +.++++... ++.++.. ..+.+.+ T Consensus 2 ~~~i~Ig~~~~~~~------------------~~~~~~~a~~~in~~~~~~-~~~i~l~~~-~~~~~~~----~~~~~~~ 57 (364) T 5EWM_D 2 PPSIGIAVILVGTS------------------DEVAIKDAHEKDDFHHLSV-VPRVELVAM-NETDPKS----IITRICD 57 (364) T ss_dssp CCEEEEEEEEESSC------------------CHHHHHC------CCCSSS-EEEEEEEEE-CCCSHHH----HHHHHHH T ss_pred CCeeeEEEEEeCCC------------------chHHHHHHHHhcCCCcCcc-CCceEEEee-CCCCHHH----HHHHHHH Confidence 46789999998652 4578999999999875432 455666655 3444322 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVI--GAAASS-VSIMVANILRLFKIPQISYASTAP-ELSDNTRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vI--g~~~s~-~~~~va~~~~~~~iP~Is~~~~~~-~l~~~~~~~~~~~~~~~ 198 (908) ++. .+++++++ |+.++. .+..+..++...++|+|++.+..+ .+.+...+++++++.|+ T Consensus 58 l~~------------------~~~v~~vi~~g~~~s~~~~~~~~~~~~~~~iP~i~~~~~~~~~~~~~~~~~~~~~~~~~ 119 (364) T 5EWM_D 58 LMS------------------DRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPS 119 (364) T ss_dssp HHH------------------HSCEEEEEEECSSCCTHHHHHHHHHHHHHTCCEEEEEGGGSSCCCSCCTTCCEEESSCC T ss_pred HHh------------------cCCceEEEEcCCCChHHHHHHHHHHHHhhCCCEEeecCCCcccccCcccCcceeecCCC Confidence 332 14789999 887775 466777788889999999876542 33333357899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~v 277 (908) +...++++++++++++|+++++++.++.++....+.+++.+++. ++++.....+..... ..++...+++++. .++++ T Consensus 120 ~~~~~~~~~~~~~~~~~~~i~il~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~~ 197 (364) T 5EWM_D 120 IEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS-FVGWELEEVLLLDMSLDDGDSKIQNQLKK-LQSPI 197 (364) T ss_dssp HHHHHHHHHHHHHHHTCCEEEEEEESSTTHHHHHHHHHHHHHSC-CSSCEEEEEEEECCSSCCTTCHHHHHHTT-CCCSE T ss_pred HHHHHHHHHHHHHHcCCeEEEEEEEcCCchHHHHHHHHHHHHhh-CCcEEEEEEEecCCCCCcchHHHHHHHHh-CCCCE Confidence 98889999999988899999999987777777778888877765 355443222210011 2345566666753 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+....+..+++++++.|+.. .+.|+..+.+...... .......+.+.+ . T Consensus 198 v~~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~~---------------------~--- 251 (364) T 5EWM_D 198 ILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDT--VPAEFPTGLISV---------------------S--- 251 (364) T ss_dssp EEEESCHHHHHHHHHHHHHTTCSSTTCEEEECHHHHCSTTC--CCTTSCTTCEEE---------------------E--- T ss_pred EEEeCCHHHHHHHHHHHHHcCCCCCcEEEEeecCCCCCCCC--CCccCCCcEEEE---------------------e--- Confidence 888877777788899998888753 3566665422111000 000000010000 0 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIGLCPRM 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~~~~~~ 434 (908) . ..+ ...++..+|||++++++|++++....+.. ....|... T Consensus 252 --~-----~~~------------------------------~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~c~~~ 294 (364) T 5EWM_D 252 --Y-----DEW------------------------------DYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNT 294 (364) T ss_dssp --E-----CTT------------------------------TSCHHHHHHHHHHHHHHHHHHHHHHHSCCCCCCSCSSCS T ss_pred --e-----cCc------------------------------ccCccHHHHHHHHHHHHHHHHHHhhCCCCCCCCCccccC Confidence 0 000 01235679999999999999886532110 01223211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ...++..+.++|++..|.| | .+.|+++|++. ..+.|++++. +..++.||.|+... +....+.|+ T Consensus 295 ~~~~~~~~~~l~~~l~~~~~~g--g-~~~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 362 (364) T 5EWM_D 295 HEKRIYQSNMLNRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNK---ERKWERVGKWKDKS-LQMKYYVWP 362 (364) T ss_dssp GGGGGGCCCTTHHHHTSCCCC-----CCCBCTTSBBSSCCEEEEEECT---TSCEEEEEEECSSC-EEESCSSCC T ss_pred ccceeehHHHHHHHheeeEecC--e-eeeeCCCCccccceEEEEEecC---CccEEEeEEEECCe-eeeeceecC Confidence 1124566778888888988 7 89999999886 5788888873 24688999998762 322345563 No 90 >4MLC_A Extracellular ligand-binding receptor; Structural Genomics, PSI-Biology, Midwest Center; HET: MSE, SO4; 2.705A {Desulfitobacterium hafniense} Probab=99.51 E-value=1.1e-18 Score=185.42 Aligned_cols=346 Identities=20% Similarity=0.252 Sum_probs=211.0 Template_Neff=12.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+. .+.....+++.|++++|+.+++ .|.++++.+.|+.+++.. ..+. T Consensus 5 ~~~~~~~~Ig~~~~~~~--------------~~~~~~~~~~~a~~~~n~~~~~-~g~~~~~~~~d~~~~~~~----~~~~ 65 (356) T 4MLC_A 5 VNPSEEIFIGVAWPFAS--------------LDDLFAEGLELAVQEINEQGGV-QGRKLSLVKADDEAELEK----GLAI 65 (356) T ss_dssp ----CEEEEEEEECCTT--------------CCSSHHHHHHHHHHHHHTTTTB-TTBEEEEEEEECTTCHHH----HHHH T ss_pred cCCCCcEEEEEEcCCCC--------------ccHHHHHHHHHHHHHHHHcCCc-CCeeEEEEEEcCcccHHH----HHHH Confidence 34567899999999642 3456788999999999987654 367788888887665432 2333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. .++++++|++.++.....+...+...++|+|++....+.+... .+++++++.+++ T Consensus 66 ~~~l~~------------------~~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~ 126 (356) T 4MLC_A 66 AQAFAD------------------NAGIQAVIGHRNSFISIPAASIYDQAGLVMLSPASTSPDLTDH-GYIHVFRNIPSD 126 (356) T ss_dssp HHHHHT------------------CTTEEEEECCSSHHHHHHHHHHHHHHTCEEEESSCCCGGGGSS-CCSSEEESSCCH T ss_pred HHHHHH------------------cCCccEEEcCCCchhhHHHHHHHHHhCCeEEEcCcCCcccccC-CCCCeEECCCCH Confidence 333332 1478999988776666666777888999999887655443221 356788899988 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++++++ T Consensus 127 ~~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~v~ 202 (356) T 4MLC_A 127 QEIARQLAIYLAEQGHERMVIYYTDDSYGNGLANAFEDYARAQ-GITIVDRFNYY--GNLKDLERLYDKWQA-FGMDGIF 202 (356) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSHHHHHHHHHHHHHHHHT-TCEEEEEESCC--CSHHHHHHHHHHHHH-HTCCEEE T ss_pred HHHHHHHHHHHHHcCCCEEEEEEcCCcchhHHHHHHHHHHHHC-CCeEeEEEecC--CCCccHHHHHHHHHH-cCCCEEE Confidence 8888999999888899999999966667777888888888775 45554322221 122345556666653 4778887 Q NP_000836.2 280 MFANE-DDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAP--VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 280 ~~~~~-~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~--~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +.... ..+..+++++++.|+. .+|++.+.|...... .........+.+..... ... ...+.. T Consensus 203 ~~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~~---~~~~~~ 267 (356) T 4MLC_A 203 IAKTATGGGTEFLVDAKSVGIE--VPLIAGNSWDALSLTEDIENIGMTAEGLLVGSFF----------NPQ---RPDSRT 267 (356) T ss_dssp EESCCCCCCHHHHHHHHHHTCC--SCEEECGGGCC----------CGGGTTCEEEEEC----------CTT---CSSHHH T ss_pred EEecCccchHHHHHHHHHcCCC--CCEEecCccchhchHHHHHHhhhhhcCeEEEecC----------CCC---CCChhH Confidence 76543 3567788888887773 456655544321100 00000111121111100 000 000111 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) ..|.+.+++.++ ..++.++..+|||++++++|+++... T Consensus 268 ~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~--------------- 305 (356) T 4MLC_A 268 QDFVEAFRREYG---------------------------QPPTSYAAAGYDAVILLAEALEKSDL--------------- 305 (356) T ss_dssp HHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHTTSCS--------------- T ss_pred HHHHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHhCCC--------------- Confidence 122222222111 11235677899999999999987642 Q NP_000836.2 437 IDGKELLGYIRA-VNFNGSAGTPVTFNENGDAPGRYD-IFQYQITNKSTEYKVIG 489 (908) Q Consensus 437 ~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~~~~~-i~~~~~~~~~~~~~~Vg 489 (908) .+++.+.+.|++ ..|.|.+| .+.|+++|++...+. +.++. ++.++.+| T Consensus 306 ~~~~~~~~~l~~~~~~~g~~G-~~~f~~~g~~~~~~~~~~~~~----~g~~~~~~ 355 (356) T 4MLC_A 306 THPATLAQGLRDLGPWEGVMG-MHRFDGRGDDIGDLVVLKKMK----DGRFEYLG 355 (356) T ss_dssp SSTTHHHHHHHHHCSEEETTE-EECBCTTCCBCSSCEEEEEEE----TTEEEEC- T ss_pred CCHHHHHHHHHhhCCCCCcce-eEEECCCCCcccceEEEEEEE----CCEEEEcC Confidence 134457777877 47899988 899999888765433 44443 24555554 No 91 >4Q6B_A Extracellular ligand-binding receptor; Structural Genomics, PSI-Biology, Midwest Center; 1.667A {Desulfitobacterium hafniense} Probab=99.51 E-value=1.1e-18 Score=185.42 Aligned_cols=346 Identities=20% Similarity=0.252 Sum_probs=211.0 Template_Neff=12.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.+. .+.....+++.|++++|+.+++ .|.++++.+.|+.+++.. ..+. T Consensus 5 ~~~~~~~~Ig~~~~~~~--------------~~~~~~~~~~~a~~~~n~~~~~-~g~~~~~~~~d~~~~~~~----~~~~ 65 (356) T 4Q6B_A 5 VNPSEEIFIGVAWPFAS--------------LDDLFAEGLELAVQEINEQGGV-QGRKLSLVKADDEAELEK----GLAI 65 (356) T ss_dssp ----CEEEEEEEECTTT--------------CCSSHHHHHHHHHHHHHHTTCB-TTBEEEEEEEECTTCHHH----HHHH T ss_pred cCCCCcEEEEEEcCCCC--------------ccHHHHHHHHHHHHHHHHcCCc-CCeeEEEEEEcCcccHHH----HHHH Confidence 34567899999999642 3456788999999999987654 367788888887665432 2333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. .++++++|++.++.....+...+...++|+|++....+.+... .+++++++.+++ T Consensus 66 ~~~l~~------------------~~~v~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~-~~~~~~~~~~~~ 126 (356) T 4Q6B_A 66 AQAFAD------------------NAGIQAVIGHRNSFISIPAASIYDQAGLVMLSPASTSPDLTDH-GYIHVFRNIPSD 126 (356) T ss_dssp HHHHHT------------------CTTEEEEECCSSHHHHHHHHHHHHHHTCCEEESSCCCGGGGSS-CCSSEEESSCCH T ss_pred HHHHHH------------------cCCccEEEcCCCchhhHHHHHHHHHhCCeEEEcCcCCcccccC-CCCCeEECCCCH Confidence 333332 1478999988776666666777888999999887655443221 356788899988 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++++++ T Consensus 127 ~~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~v~ 202 (356) T 4Q6B_A 127 QEIARQLAIYLAEQGHERMVIYYTDDSYGNGLANAFEDYARAQ-GITIVDRFNYY--GNLKDLERLYDKWQA-FGMDGIF 202 (356) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEECSSHHHHHHHHHHHHHHHHT-TCEEEEEESCC--CSHHHHHHHHHHHHH-TTCCEEE T ss_pred HHHHHHHHHHHHHcCCCEEEEEEcCCcchhHHHHHHHHHHHHC-CCeEeEEEecC--CCCccHHHHHHHHHH-cCCCEEE Confidence 8888999999888899999999966667777888888888775 45554322221 122345556666653 4778887 Q NP_000836.2 280 MFANE-DDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAP--VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 280 ~~~~~-~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~--~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +.... ..+..+++++++.|+. .+|++.+.|...... .........+.+..... ... ...+.. T Consensus 203 ~~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----------~~~---~~~~~~ 267 (356) T 4Q6B_A 203 IAKTATGGGTEFLVDAKSVGIE--VPLIAGNSWDALSLTEDIENIGMTAEGLLVGSFF----------NPQ---RPDSRT 267 (356) T ss_dssp EESCCCCCCHHHHHHHHHHTCC--SCEEECGGGTCC-----------TTTTCEEEEEC----------CTT---CCCHHH T ss_pred EEecCccchHHHHHHHHHcCCC--CCEEecCccchhchHHHHHHhhhhhcCeEEEecC----------CCC---CCChhH Confidence 76543 3567788888887773 456655544321100 00000111121111100 000 000111 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) ..|.+.+++.++ ..++.++..+|||++++++|+++... T Consensus 268 ~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~--------------- 305 (356) T 4Q6B_A 268 QDFVEAFRREYG---------------------------QPPTSYAAAGYDAVILLAEALEKSDL--------------- 305 (356) T ss_dssp HHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHTSCT--------------- T ss_pred HHHHHHHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHhCCC--------------- Confidence 122222222111 11235677899999999999987642 Q NP_000836.2 437 IDGKELLGYIRA-VNFNGSAGTPVTFNENGDAPGRYD-IFQYQITNKSTEYKVIG 489 (908) Q Consensus 437 ~~~~~l~~~l~~-~~f~G~~G~~v~Fd~~G~~~~~~~-i~~~~~~~~~~~~~~Vg 489 (908) .+++.+.+.|++ ..|.|.+| .+.|+++|++...+. +.++. ++.++.+| T Consensus 306 ~~~~~~~~~l~~~~~~~g~~G-~~~f~~~g~~~~~~~~~~~~~----~g~~~~~~ 355 (356) T 4Q6B_A 306 THPATLAQGLRDLGPWEGVMG-MHRFDGRGDDIGDLVVLKKMK----DGRFEYLG 355 (356) T ss_dssp TCGGGHHHHHHHTCSEEETTE-EECBCTTSCBCSSCEEEEEEE----TTEEEEC- T ss_pred CCHHHHHHHHHhhCCCCCcce-eEEECCCCCcccceEEEEEEE----CCEEEEcC Confidence 134457777877 47899988 899999888765433 44443 24555554 No 92 >3TD9_A Branched chain amino acid ABC; leucine binding, Structural Genomics, Joint; HET: EDO, PHE; 1.9A {Thermotoga maritima} Probab=99.51 E-value=1.1e-18 Score=186.24 Aligned_cols=347 Identities=22% Similarity=0.238 Sum_probs=217.8 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) -++++||++.|.++... ..+.....|++.|++++|.. .|+++++.+.|+.+++.. ..+.+++ T Consensus 14 ~~~i~ig~~~p~sg~~~----------~~~~~~~~g~~~a~~~~~~~----~g~~v~l~~~d~~~~~~~----~~~~~~~ 75 (366) T 3TD9_A 14 RKVVKIAVILPMTGGIS----------AFGRMVWEGIQIAHEEKPTV----LGEEVELVLLDTRSEKTE----AANAAAR 75 (366) T ss_dssp --CEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHCCEE----TTEEEEEEEEECTTCHHH----HHHHHHH T ss_pred CCceEEEEEEccCCCch----------HHHHHHHHHHHHHHHhCCCC----CCeEEEEEEEcCCCCHHH----HHHHHHH Confidence 46799999999987532 35677889999999988642 367788888887655332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .+++++++++.++.....+...+...++|+|.+.+..+.+.. ..++++++.+++... T Consensus 76 l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~~~ 135 (366) T 3TD9_A 76 AID------------------KEKVLAIIGEVASAHSLAIAPIAEENKVPMVTPASTNPLVTQ--GRKFVSRVCFIDPFQ 135 (366) T ss_dssp HHH------------------TSCCSEEEECSSHHHHHHHHHHHHHTTCCEEESSCCCGGGTT--TCSSEEESSCCHHHH T ss_pred HHH------------------hcCccEEEccCCchHHHHHHHHHHHcCCCEEccCCCCccccC--CCceeeEecCCcHHH Confidence 332 147889999877766666777788899999998776544322 246778888888888 Q NP_000836.2 203 AQAMVDIV-TALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l-~~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++.+++++ ++.+|+++++++. ++.++..+.+.+++.+++. ++++.. ..+. ....+....+++++. .+++++++ T Consensus 136 ~~~~~~~l~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~~-g~~~~~-~~~~--~~~~~~~~~~~~~~~-~~~~~iv~ 210 (366) T 3TD9_A 136 GAAMAVFAYKNLGAKRVVVFTDVEQDYSVGLSNFFINKFTEL-GGQVKR-VFFR--SGDQDFSAQLSVAMS-FNPDAIYI 210 (366) T ss_dssp HHHHHHCCCCCSCCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEE-EEEC--TTCCCCHHHHHHHHH-TCCSEEEE T ss_pred HHHHHHHHHHhcCCCEEEEEEeCCChhhHHHHHHHHHHHHHC-CCeEEE-EEEC--CCCCChHHHHHHHHh-hCCCEEEE Confidence 88888888 5578999999984 4556667778888877765 355432 1222 122345566666663 57888877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ...+..+..+++++++.|+.. .+++.+.+...... ........+.+...... .. ....+....|. T Consensus 211 ~~~~~~~~~~~~~~~~~g~~~--~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~~--~~~~~~~~~f~ 275 (366) T 3TD9_A 211 TGYYPEIALISRQARQLGFTG--YILAGDGADAPELI-EIGGEAVEGLLFTTHYH----------PK--AASNPVAKKFV 275 (366) T ss_dssp CSCHHHHHHHHHHHHHTTCCS--EEEECGGGCSTHHH-HHHGGGGTTCEEEESCC----------GG--GCCSHHHHHHH T ss_pred cCCHHHHHHHHHHHHHcCCCc--EEEecCccCcHHHH-HHhhHHhCceEEEecCC----------cc--cCCCHHHHHHH Confidence 765566777888888888742 33433322211100 00011122322211100 00 00001111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..++.++..+|||+++++++++++.. .+++ T Consensus 276 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~~~~ 313 (366) T 3TD9_A 276 EVYKEKYG---------------------------KEPAALNALGYDAYMVLLDAIERAGS---------------FDRE 313 (366) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHHHC---------------------------CCCcHHHHHHHHHHHHHHHHHHHcCC---------------CCHH Confidence 22222111 11234677899999999999988642 1345 Q NP_000836.2 441 ELLGYIRAV-NFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++. .|.|.+| ++.|+++|++...+.+.+++ ++.++.+|.|++. T Consensus 314 ~l~~~l~~~~~~~g~~G-~~~f~~~g~~~~~~~i~~~~----~~~~~~~~~w~~~ 363 (366) T 3TD9_A 314 KIAEEIRKTRNFNGASG-IINIDENGDAIKSVVVNIVK----NGSVDFEAVINPD 363 (366) T ss_dssp HHHHHHTTCCSEEETTE-EECBCTTSCBCCCEEEEEEE----TTEEEEEEEECGG T ss_pred HHHHHHHcCCCcccccE-EEEECCCCCccceEEEEEEE----CCEEEEeEEeCcc Confidence 677777765 7889888 89999988887788888886 3578888888753 No 93 >3N0W_B ABC branched chain amino acid; Receptor family ligand binding region; HET: MSE; 1.88A {Burkholderia xenovorans} Probab=99.50 E-value=1.7e-18 Score=185.85 Aligned_cols=350 Identities=13% Similarity=0.170 Sum_probs=216.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||+++|.++... ...+.....|++.|++++|. + ..|+++++.+.|+.+++.. ..+.++ T Consensus 3 ~~~~~~Ig~i~~~~~~~~---------~~~~~~~~~g~~~a~~~~~~--~-~~g~~i~~~~~d~~~~~~~----~~~~~~ 66 (379) T 3N0W_B 3 STGQVTLGVLTDMSSVYA---------DSAGKGSVAAVQLAIEDVGG--K-ALGQPVKLVSADYQMKTDV----ALSIAR 66 (379) T ss_dssp ---CCEEEEEECSSSTTT---------TTSHHHHHHHHHHHHHTTTT--E-ETTEECEEEEEECTTCHHH----HHHHHH T ss_pred CCccEEEEEEecCCCcch---------hhcCHHHHHHHHHHHHHhCC--c-cCCeeEEEEEEcCCCCHHH----HHHHHH Confidence 456899999999876421 01456788999999999972 2 2467788888887655432 333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .+++++++++.++.....+...+...++|+|.+....+.+.....+++++++.++... T Consensus 67 ~l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 128 (379) T 3N0W_B 67 EWFD------------------RDGVDAIFDVVNSGTALAINNLVKDKKKLAFITAAAADQIGGTECNGYGIGFLYNFTS 128 (379) T ss_dssp HHHH------------------TSCCCEEEECCSHHHHHHHHHHHHHHTCEEEECSCCCTTTTTTTCCSSEEECSCCHHH T ss_pred HHHH------------------HhCCCEEEeCCCHHHHHHHHHHHHhcCCeEEEcCccccccCCCccCCceeEcccCHHH Confidence 4332 1478899998777666666777888899999887655443322235678888888888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++++++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..++...+++++. .++|++++. T Consensus 129 ~~~~~~~~l~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~iv~~ 204 (379) T 3N0W_B 129 IVKTVVQAQLAKGYKTWFLMLPDAAYGDLMNAAIRRELTAG-GGQIVGSVRFP--FETQDFSSYLLQAKA-SGAQLIVST 204 (379) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-TTCSEEEEC T ss_pred HHHHHHHHHHHcCCCEEEEEccccHHHHHHHHHHHHHHHHC-CCEEEEEEEeC--CCCCChHHHHHHHHH-cCCCEEEEE Confidence 88888888877899999999976677888888888888775 35554332222 122345566677663 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+..++.+++.. +...... .... ....+.+.... +.. ...+....|. T Consensus 205 ~~~~~~~~~~~~~~~~g~~~~~~~~~~~-~~~~~~~-~~~~~~~~~g~~~~~~----------~~~----~~~~~~~~f~ 268 (379) T 3N0W_B 205 SGGAANINIMKQAREFGLPSKTQKVGGM-IDILTDV-KSAGLRVMQGQEYATS----------FYW----NMDDRTRAFA 268 (379) T ss_dssp CCHHHHHHHHHHHHTTTCSCSSCEEECC-BCCHHHH-HHHCHHHHTTCEEEES----------CCT----TSSHHHHHHH T ss_pred cChHHHHHHHHHHHHcCCCccceeeech-hhHHHHH-HHhchhhhcCCceecc----------ccc----CCCHHHHHHH Confidence 6666778888898888775333333321 1110000 0000 11112111100 000 0011112222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ..++.++..+|||+++++.|++++.. .+++ T Consensus 269 ~~~~~~~~---------------------------~~p~~~~~~~yda~~~~~~al~~~~~---------------~~~~ 306 (379) T 3N0W_B 269 KRFYAKMG---------------------------KMPTNNQAGGYSAALQYLKAVNAIGS---------------KDPQ 306 (379) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTC---------------CCHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHHCC---------------CCHH Confidence 22222211 11234567899999999999988642 2355 Q NP_000836.2 441 ELLGYIRAVNFN-GSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 441 ~l~~~l~~~~f~-G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.++|++..|. |.+| .+.|+++|++...+.+.+++. .. ..+|.|.. T Consensus 307 ~l~~~l~~~~~~~g~~g-~~~f~~~~~~~~~~~i~~~~~----~~-~~~~~w~~ 354 (379) T 3N0W_B 307 KVFAYLKTIKFDDAVTR-HGTLRPGGRLVRDMYLVRAKK----PE-DQKGDWDY 354 (379) T ss_dssp HHHHHHTTCCBCSSSCC-SBEECTTSBEECCEEEEEECC----GG-GCCSTTCC T ss_pred HHHHHHhcCccccCCCC-ceeeCCCCcEEEeEEEEEEcC----Cc-cCCCChhh Confidence 677888877786 7788 899998887777788888873 12 45677764 No 94 >1PEA_A AMIDASE OPERON, ACETAMIDE; GENE REGULATOR, RECEPTOR, BINDING PROTEIN; 2.1A {Pseudomonas aeruginosa} SCOP: c.93.1.1 Probab=99.49 E-value=1.8e-18 Score=186.08 Aligned_cols=354 Identities=11% Similarity=0.073 Sum_probs=219.0 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++.. ..+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~----~~~~~~ 68 (385) T 1PEA_A 4 HQERPLIGLLFSETGVTA----------DIERSQRYGALLAVEQLNREGGVG-GRPIETLSQDPGGDPDR----YRLCAE 68 (385) T ss_dssp ----CEEEEECCSSSTTH----------HHHHHHHHHHHHHHHHHHTTTTBT-TBCCEEEEECCTTCHHH----HHHHHH T ss_pred CCCCCEEEEEEcCCCCcc----------hHHHHHHHHHHHHHHHHHHcCCcC-CeeeEEEEECCCCCHHH----HHHHHH Confidence 457899999999876421 256678899999999999876543 67888888887665432 233334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++.++.....+...+...++|+|++....+. ...++++++.++... T Consensus 69 ~l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~~~~ 126 (385) T 1PEA_A 69 DFIR------------------NRGVRFLVGCYMSHTRKAVMPVVERADALLCYPTPYEGF----EYSPNIVYGGPAPNQ 126 (385) T ss_dssp HHHH------------------TTCCCEEEECCSHHHHHHHHHHHHHTTCEEEECSCCCCC----CCCTTEEECSCCGGG T ss_pred HHHH------------------hcCceEEEeccccHHHHhhHHHHhhcCCEEEecCCCCCC----CCCCcEEEecCChhh Confidence 3332 147889999887766667777888899999988764321 124678888888888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+.......++...+++++. .++|++++. T Consensus 127 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~ii~~ 204 (385) T 1PEA_A 127 NSAPLAAYLIRHYGERVVFIGSDYIYPRESNHVMRHLYRQH-GGTVLEEIYIPLYPSDDDLQRAVERIYQ-ARADVVFST 204 (385) T ss_dssp THHHHHHHHHTTTCSEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSCCHHHHHHHHHHHHH-HTCSEEEEE T ss_pred hhHHHHHHHHHHhCCcEEEEecCCcchHHHHHHHHHHHHHC-CCeEEEEEEeCCCCCchhHHHHHHHHHH-cCCCEEEEE Confidence 88889999887899999999976677778888888888765 3555432211110112345566666663 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+.. .+.|+..+ ...... .........+.+...+.. . ....+....|. T Consensus 205 ~~~~~~~~~~~~~~~~g~~~~~~~~~~~~-~~~~~~-~~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 269 (385) T 1PEA_A 205 VVGTGTAELYRAIARRYGDGRRPPIASLT-TSEAEV-AKMESDVAEGQVVVAPYF----------S---SIDTPASRAFV 269 (385) T ss_dssp CCTHHHHHHHHHHHHHHCSSCCCCEEESS-CCHHHH-TTSCHHHHTTCEEEESCC----------T---TCSSHHHHHHH T ss_pred ccchHHHHHHHHHHHHhCCCCCCCeeEee-CCHHHH-HhcccchhcCCEEEeccc----------c---CCCCHHHHHHH Confidence 66667778888888877542 33444332 111000 000011122222111100 0 00011112222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++. ...+..++..+||++++++.++++... .+++ T Consensus 270 ~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~---------------~~~~ 309 (385) T 1PEA_A 270 QACHGFFPE-------------------------NATITAWAEAAYWQTLLLGRAAQAAGN---------------WRVE 309 (385) T ss_dssp HHHHTTSCT-------------------------TCCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHhCCC-------------------------CCCCCHHHHHHHHHHHHHHHHHHHhCC---------------CCHH Confidence 222221110 011234677899999999999987642 1345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.+.|++..|.|.+| ++.|+++|++. ..+.+.+++. ++.++.++.++. T Consensus 310 ~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~---~g~~~~~~~~~~ 359 (385) T 1PEA_A 310 DVQRHLYDIDIDAPQG-PVRVERQNNHSRLSSRIAEIDA---RGVFQVRWQSPE 359 (385) T ss_dssp HHHHHHTTCCEEETTE-EEEECTTTSCEEBCCEEEEECT---TSCEEEEEECSS T ss_pred HHHHHHhcCCcccCCc-eEEEeCCCCeeeeeeEEEEEcC---CCCEeEEEeCCC Confidence 6778888888999988 89999766653 4667777752 246777776654 No 95 >1QO0_B AMIC, AMIR; BINDING PROTEIN, GENE REGULATOR, RECEPTOR; HET: BMD; 2.25A {PSEUDOMONAS AERUGINOSA} SCOP: c.93.1.1 Probab=99.49 E-value=1.8e-18 Score=186.08 Aligned_cols=354 Identities=11% Similarity=0.073 Sum_probs=219.8 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+.+++.. ..+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~----~~~~~~ 68 (385) T 1QO0_B 4 HQERPLIGLLFSETGVTA----------DIERSQRYGALLAVEQLNREGGVG-GRPIETLSQDPGGDPDR----YRLCAE 68 (385) T ss_dssp ---CCEEEEECCSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCCEEEECCCTTCHHH----HHHHHH T ss_pred CCCCCEEEEEEcCCCCcc----------hHHHHHHHHHHHHHHHHHHcCCcC-CeeeEEEEECCCCCHHH----HHHHHH Confidence 457899999999876421 256678899999999999876543 67888888887665432 233334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++++++|++.++.....+...+...++|+|++....+. ...++++++.++... T Consensus 69 ~l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~~~~ 126 (385) T 1QO0_B 69 DFIR------------------NRGVRFLVGCYMSHTRKAVMPVVERADALLCYPTPYEGF----EYSPNIVYGGPAPNQ 126 (385) T ss_dssp HHHH------------------HSCCCEEEECCSHHHHHHHHHHHHHHTCEEEECSCCCCC----CCCTTEEECSCCGGG T ss_pred HHHH------------------hcCceEEEeccccHHHHhhHHHHhhcCCEEEecCCCCCC----CCCCcEEEecCChhh Confidence 3332 147889999887766667777888899999988764321 124678888888888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+.......++...+++++. .++|++++. T Consensus 127 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~ii~~ 204 (385) T 1QO0_B 127 NSAPLAAYLIRHYGERVVFIGSDYIYPRESNHVMRHLYRQH-GGTVLEEIYIPLYPSDDDLQRAVERIYQ-ARADVVFST 204 (385) T ss_dssp THHHHHHHHHHHSCSEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEECSSCCHHHHHHHHHHHHH-HTCSEEEEE T ss_pred hhHHHHHHHHHHhCCcEEEEecCCcchHHHHHHHHHHHHHC-CCeEEEEEEeCCCCCchhHHHHHHHHHH-cCCCEEEEE Confidence 88889999887899999999976677778888888888765 3555432211110112345566666663 578888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+.. .+.|+..+ ...... .........+.+...+.. . ....+....|. T Consensus 205 ~~~~~~~~~~~~~~~~g~~~~~~~~~~~~-~~~~~~-~~~~~~~~~~~~~~~~~~----------~---~~~~~~~~~f~ 269 (385) T 1QO0_B 205 VVGTGTAELYRAIARRYGDGRRPPIASLT-TSEAEV-AKMESDVAEGQVVVAPYF----------S---SIDTPASRAFV 269 (385) T ss_dssp CCSTTHHHHHHHHHHHSCSSSCCCEEESS-CCHHHH-TTSCHHHHTTCEEEESCC----------T---TCCSHHHHHHH T ss_pred ccchHHHHHHHHHHHHhCCCCCCCeeEee-CCHHHH-HhcccchhcCCEEEeccc----------c---CCCCHHHHHHH Confidence 66667778888888877542 33444332 111000 000011122222111100 0 00011112222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++. ...+..++..+||++++++.++++... .+++ T Consensus 270 ~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~---------------~~~~ 309 (385) T 1QO0_B 270 QACHGFFPE-------------------------NATITAWAEAAYWQTLLLGRAAQAAGN---------------WRVE 309 (385) T ss_dssp HHHHTTSCT-------------------------TCCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHhCCC-------------------------CCCCCHHHHHHHHHHHHHHHHHHHhCC---------------CCHH Confidence 222221110 011234677899999999999987642 1345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.+.|++..|.|.+| ++.|+++|++. ..+.+.+++. ++.++.++.++. T Consensus 310 ~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~---~g~~~~~~~~~~ 359 (385) T 1QO0_B 310 DVQRHLYDIDIDAPQG-PVRVERQNNHSRLSSRIAEIDA---RGVFQVRWQSPE 359 (385) T ss_dssp HHHHTTTTCCEEETTE-EEEECTTTSBEEBCCEEEEECT---TSCEEEEEECSS T ss_pred HHHHHHhcCCcccCCc-eEEEeCCCCeeeeeeEEEEEcC---CCCEeEEEeCCC Confidence 6778888888999988 89999766653 4667777752 246777776654 No 96 >4KV7_A Probable leucine/isoleucine/valine-binding protein; structural genomics, PSI-Biology, Protein Structure; 1.2A {Rhodopirellula baltica} Probab=99.49 E-value=1.9e-18 Score=185.53 Aligned_cols=349 Identities=15% Similarity=0.149 Sum_probs=214.2 Template_Neff=11.900 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......++++||+++|.++... ..+.....+++.|++++|+.+++. |+++++.+.|+++++.. .. T Consensus 10 ~~~~~~~~~~Ig~~~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~~-g~~i~~~~~d~~~~~~~----~~ 74 (381) T 4KV7_A 10 ATPVDAQLLKFGMSTALSGPAA----------ELGINMRHGILAAFDEAKAKNHLP-SKTLKLIALDDGYEPAR----TA 74 (381) T ss_dssp CCCCCCEEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTSST-TEEEEEEEEECTTCHHH----HH T ss_pred CCCCCcceEEEEEEeCCCCccH----------HHHHHHHHHHHHHHHHHHHhCCCC-CceeEEEEEcCCCCHhh----HH Confidence 3455678999999999876421 256678899999999999876543 67888888887766433 33 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.+++++. .++++++|++.++.....+...+...+||+|.+....+.+.....+++++++.+ T Consensus 75 ~~~~~l~~------------------~~~~~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 136 (381) T 4KV7_A 75 PNMHRLTD------------------EHEVLAVVGNVGTPTAITAIPIAQQTKTPFFGAFTGASALRKTESVEFVINYRA 136 (381) T ss_dssp HHHHHHHT------------------TTCCSCEECCBCHHHHHHHHHHHHHTTCCEESCBCCCGGGCC---CTTEEBCSC T ss_pred HHHHHHHh------------------hCCeeEEEeCCCcHHHHHHHHHHHhhCCCEEeeecCchHhcCCCCCceEEECCc Confidence 33444332 147889999887776677778888999999998776554432224677888989 Q NP_000836.2 198 PDSYQAQAMVDIVTA--LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQ--KIPREPRPGEFEKIIKRLLE-T 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~--~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~~~~~~~~~~~~~~~l~~-~ 272 (908) +....+.++++++.+ .+|++|++++.++.++....+.+.+.+++..++++.... .+. .+..++...+++++. . T Consensus 137 ~~~~~~~~~~~~l~~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~g~~v~~~~~~~~~--~~~~~~~~~~~~~~~~~ 214 (381) T 4KV7_A 137 SYAEETAAMVDALVAKGIKPEEIGFFTQNDSYGDDGFFGGLAAIRRHQSVKVSSLPHGRYR--RNTSQVEDGLADLLMHQ 214 (381) T ss_dssp CHHHHHHHHHHHHHHTTCCGGGEEEEEESSHHHHHHHHHHHHHHHHHSCCCGGGSCEEEEC--TTCCCCHHHHHHHHTCS T ss_pred CHHHHHHHHHHHHHHCCCCccEEEEEEeCCcchHhhHHHHHHHHHHcCCCcceecCCCCCC--CCCccHHHHHHHHHhcC Confidence 888888889988854 578999999976667777777888777652134443211 111 112344555666541 2 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLAN 352 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~ 352 (908) .++|+|++...+..+..+++++++.|+. ..|++.+.+...... ........+.+....... . ... T Consensus 215 ~~~~~i~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~--------~----~~~ 279 (381) T 4KV7_A 215 PLPKAVIMVGTYEPCSKLIRMARMNNFN--PQFLAVSFVGADALQ-RSLGDLANGIVATQVVPH--------F----DSD 279 (381) T ss_dssp SCCSEEEEESCHHHHHHHHHHHHHTTCC--CEEEECGGGCHHHHH-HHHGGGGTTCEEEESSCC--------T----TCC T ss_pred CCCCEEEEECChHHHHHHHHHHHhCCCC--CcEEEEeccCHHHHH-HHHHHhcccEEEEEeeCC--------C----CCC Confidence 4688887776666677888888887764 345554433221110 000111222221110000 0 000 Q NP_000836.2 353 NRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCP 432 (908) Q Consensus 353 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~ 432 (908) .+....|.+.+++.+.. .....++..+|||++++++++++.... T Consensus 280 ~~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~al~~~~~~---------- 323 (381) T 4KV7_A 280 LPLVREYRDAMRDYDPE--------------------------LPLSFVSLEGYIVGRILVKAVTSIKGE---------- 323 (381) T ss_dssp SHHHHHHHHHHHHHCTT--------------------------SCCCHHHHHHHHHHHHHHHHHHHCCSC---------- T ss_pred CHHHHHHHHHHHHhCCC--------------------------CCCChhhHHHHHHHHHHHHHHHhcCCC---------- Confidence 01111222222211110 112345778999999999999876421 Q NP_000836.2 433 RMSTIDGKELLGYIRAV-NFN-GSAGTPVTFNENGDAP-GRYDIFQYQ 477 (908) Q Consensus 433 ~~~~~~~~~l~~~l~~~-~f~-G~~G~~v~Fd~~G~~~-~~~~i~~~~ 477 (908) .+++.+.+.|++. .|. |.+| ++.|+++|++. ..+.+++++ T Consensus 324 ----~~~~~l~~~l~~~~~~~~g~~g-~i~f~~~~~~~~~~~~i~~~~ 366 (381) T 4KV7_A 324 ----ISRSSIAAALEQLGQFDIGLGA-PLTLGPNDHQASSKVWPVLIG 366 (381) T ss_dssp ----CCHHHHHHHHHHTEEECSSSSS-CEEEBTTBCBCCCCCEEEEEC T ss_pred ----CCHHHHHHHHHHcCCCcCCCCC-CcccCCCCCcccccEEEEEEc Confidence 2345677788766 787 7777 89999876543 456666665 No 97 >4OBB_B Amino acid/amide ABC transporter substrate-binding; STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER; HET: 1QQ, MSE; 1.526A {Anabaena variabilis} Probab=99.49 E-value=2e-18 Score=186.37 Aligned_cols=362 Identities=16% Similarity=0.184 Sum_probs=213.9 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++... ..+.....+++.|++++|+.+++ .|+++++.+.|+.+++.. ..+ T Consensus 27 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~-~g~~i~~~~~d~~~~~~~----~~~ 91 (395) T 4OBB_B 27 TTSDKNTIPIGIALAQTSNVA----------LLGQEQVAGAKIAEKYFNDKGGV-NGTPIKLIFQDTAGDEAG----TIN 91 (395) T ss_dssp -----CCEEEEECCCCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTB-TTBCEEEEECCCTTSHHH----HHH T ss_pred CCccCCcEEEEEEECCCCCcH----------HHHHHHHHHHHHHHHHHHHcCCC-CCeeeEEEEEcCCCCHHH----HHH Confidence 345678999999999875321 24567889999999999987654 367788887776655332 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++.+ .+++++|++.++.....+...+...+||+|.+....+.+.. .+++++++.++ T Consensus 92 ~~~~l~~~------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~ 151 (395) T 4OBB_B 92 AFQTLINK------------------DKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPE--IGDYVARVSAP 151 (395) T ss_dssp HHHCCCCC------------------SCCSCEECCSCHHHHHHHHHHHHHHTCCEEESSCCSTTSGG--GCTTEEESSCC T ss_pred HHHHHHhc------------------CCccEEECCCChhHHHHHHHHHHHhCCCEEcCCcCCCcCCC--CCCeEEEecCC Confidence 33433321 46788888876665566677788899999998765543321 24677888888 Q NP_000836.2 199 DSYQAQAMVDIVT--ALGWNYVSTLA-SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 199 ~~~~~~~~~~~l~--~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) +...+..+++.+. ..+|+++++++ .++.++..+.+.|++.+++. ++++.....+. ....+....+++++. .++ T Consensus 152 ~~~~~~~~~~~l~~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~ 227 (395) T 4OBB_B 152 VSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQ-GLELVTVQKFQ--TTDTDFQSQATNAIN-LKP 227 (395) T ss_dssp HHHHTHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHH-TCEEEEEEEEC--TTCCCCHHHHHHHHT-TCC T ss_pred hHHhchHHHHHHHHhCCCCCEEEEEEecCChHhHHHHHHHHHHHHHC-CCeEEEEEEeC--CCCCCHHHHHHHHHh-hCC Confidence 8777777776543 56899999998 45556777788888887765 35544322222 122344555666653 478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) ++|++...+..+..+++++++.|+. ..|++.+.+...... ........+.+...... . ....+. T Consensus 228 ~~i~~~~~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~ 291 (395) T 4OBB_B 228 DLVIISGLAADGGNLVRQLRELGYQ--GAIIGGNGLNTSNVF-AVCKALCDGVLIAQAYS----------P---EYTGEI 291 (395) T ss_dssp SEEEEESCHHHHHHHHHHHHHTTCC--SEEEECGGGCSGGGH-HHHGGGGTTCEEEESCC----------T---TCCCHH T ss_pred CEEEEECChhhHHHHHHHHHHcCCC--ceEEecCccCCHHHH-HHhHHHhCCeEEeecCC----------c---ccCCHH Confidence 8887776566677888888888774 356655433221100 00011122222111100 0 000011 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS 435 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~ 435 (908) ...|.+.+.+.++ ..+..++..+|||++++++++++....... .+. .. T Consensus 292 ~~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~~~~----~~~-~~ 339 (395) T 4OBB_B 292 NKAFRQAYVDQYK---------------------------KEPPQFSAQAFAAVQVYVESLKALDTKNKV----SKI-QL 339 (395) T ss_dssp HHHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHHHHSCG----GGS-CH T ss_pred HHHHHHHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHccccCCC----ccc-cH Confidence 1122222222111 112356788999999999999887642100 000 00 Q NP_000836.2 436 TIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 436 ~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ....+.+.+.+++..|.|.+| ++.||++|++. ..+.+++++. ..+..+|.|. T Consensus 340 ~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~~~~~~ 392 (395) T 4OBB_B 340 PELRTELNKQLLTGKYNTPLG-EISFTPIGEVVQKDFYVAQIKM----EKDGSQGKFT 392 (395) T ss_dssp HHHHHHHHHHHHHCEEEETTE-EEEECTTSCEECCCCEEEEEEE----CTTSSCEEEE T ss_pred HHHHHHHHHHHhhCCCcCCcE-EEEECCCCCccCccEEEEEEEc----cccCCcceEE Confidence 011223444455568999988 89999988875 6788888763 2344556554 No 98 >4RV5_B Amino acid/amide ABC transporter substrate-binding; Structural Genomics, PSI-Biology, Protein Structure; HET: PYR, MSE, FMT; 1.04A {Anabaena variabilis ATCC 29413} Probab=99.49 E-value=2e-18 Score=186.37 Aligned_cols=362 Identities=16% Similarity=0.184 Sum_probs=213.9 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||+++|.++... ..+.....+++.|++++|+.+++ .|+++++.+.|+.+++.. ..+ T Consensus 27 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~~~~-~g~~i~~~~~d~~~~~~~----~~~ 91 (395) T 4RV5_B 27 TTSDKNTIPIGIALAQTSNVA----------LLGQEQVAGAKIAEKYFNDKGGV-NGTPIKLIFQDTAGDEAG----TIN 91 (395) T ss_dssp -----CCEEEEECCCCSSTTH----------HHHHHHHHHHHHHHHHHHHTTTB-TTBCEEEEECCCTTSHHH----HHH T ss_pred CCccCCcEEEEEEECCCCCcH----------HHHHHHHHHHHHHHHHHHHcCCC-CCeeeEEEEEcCCCCHHH----HHH Confidence 345678999999999875321 24567889999999999987654 367788887776655332 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++.+ .+++++|++.++.....+...+...+||+|.+....+.+.. .+++++++.++ T Consensus 92 ~~~~l~~~------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~ 151 (395) T 4RV5_B 92 AFQTLINK------------------DKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPE--IGDYVARVSAP 151 (395) T ss_dssp HHHHHHHT------------------SCCSCEECCSCHHHHHHHHHHHHHHTCCEEESSCCSTTSGG--GCTTEEESSCC T ss_pred HHHHHHhc------------------CCccEEECCCChhHHHHHHHHHHHhCCCEEcCCcCCCcCCC--CCCeEEEecCC Confidence 33433321 46788888876665566677788899999998765543321 24677888888 Q NP_000836.2 199 DSYQAQAMVDIVT--ALGWNYVSTLA-SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 199 ~~~~~~~~~~~l~--~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) +...+..+++.+. ..+|+++++++ .++.++..+.+.|++.+++. ++++.....+. ....+....+++++. .++ T Consensus 152 ~~~~~~~~~~~l~~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~ 227 (395) T 4RV5_B 152 VSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQ-GLELVTVQKFQ--TTDTDFQSQATNAIN-LKP 227 (395) T ss_dssp HHHHHHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHT-TCC T ss_pred hHHhchHHHHHHHHhCCCCCEEEEEEecCChHhHHHHHHHHHHHHHC-CCeEEEEEEeC--CCCCCHHHHHHHHHh-hCC Confidence 8777777776543 56899999998 45556777788888887765 35544322222 122344555666653 478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) ++|++...+..+..+++++++.|+. ..|++.+.+...... ........+.+...... . ....+. T Consensus 228 ~~i~~~~~~~~~~~~~~~~~~~g~~--~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~~~ 291 (395) T 4RV5_B 228 DLVIISGLAADGGNLVRQLRELGYQ--GAIIGGNGLNTSNVF-AVCKALCDGVLIAQAYS----------P---EYTGEI 291 (395) T ss_dssp SEEEEESCHHHHHHHHHHHHHTTCC--SEEEECGGGCSGGGH-HHHGGGGTTCEEEESCC----------T---TCCCHH T ss_pred CEEEEECChhhHHHHHHHHHHcCCC--ceEEecCccCCHHHH-HHhHHHhCCeEEeecCC----------c---ccCCHH Confidence 8887776566677888888888774 356655433221100 00011122222111100 0 000011 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS 435 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~ 435 (908) ...|.+.+.+.++ ..+..++..+|||++++++++++....... .+. .. T Consensus 292 ~~~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~~~~~----~~~-~~ 339 (395) T 4RV5_B 292 NKAFRQAYVDQYK---------------------------KEPPQFSAQAFAAVQVYVESLKALDTKNKV----SKI-QL 339 (395) T ss_dssp HHHHHHHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHHHHSCG----GGS-CH T ss_pred HHHHHHHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHccccCCC----ccc-cH Confidence 1122222222111 112356788999999999999887642100 000 00 Q NP_000836.2 436 TIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 436 ~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ....+.+.+.+++..|.|.+| ++.||++|++. ..+.+++++. ..+..+|.|. T Consensus 340 ~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~~----~~~~~~~~~~ 392 (395) T 4RV5_B 340 PELRTELNKQLLTGKYNTPLG-EISFTPIGEVVQKDFYVAQIKM----EKDGSQGKFT 392 (395) T ss_dssp HHHHHHHHHHHHHCEEEETTE-EEEECTTSCEECCCCEEEEEEE----CTTSSCEEEE T ss_pred HHHHHHHHHHHhhCCCcCCcE-EEEECCCCCccCccEEEEEEEc----cccCCcceEE Confidence 011223444455568999988 89999988875 6788888763 2344556554 No 99 >3I45_A Twin-arginine translocation pathway signal protein; STRUCTURAL GENOMICS, CRYSTAL STRUCTURE,PROTEIN STRUCTURE; 1.36A {Rhodospirillum rubrum} Probab=99.49 E-value=2.3e-18 Score=185.44 Aligned_cols=355 Identities=15% Similarity=0.137 Sum_probs=214.7 Template_Neff=11.600 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++.. ..+.....|++.|++++|+.+++++|+++++...|+.+++.. ..+.+++ T Consensus 3 ~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~a~~~~n~~~g~~~g~~v~~~~~d~~~~~~~----~~~~~~~ 67 (387) T 3I45_A 3 LEAIRIGEINSYSQIP-----------AFTLPYRNGWQLAVEQINAAGGLLGGRPLEVISRDDGGDPGK----AVTAAQE 67 (387) T ss_dssp CCCEEEEEEECTTTCH-----------HHHHHHHHHHHHHHHHHHHTTCBTTTBCEEEEEEECTTCHHH----HHHHHHH T ss_pred CCcEEEEEecCCCCCc-----------ccCHHHHHHHHHHHHHHHHCCCccCCceeEEEEecCCCCHHH----HHHHHHH Confidence 4689999999987532 245678899999999999987776678888888877655332 2333444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++|++.++.....+...+...++|+|.+....+.+.+...+++++++.+++... T Consensus 68 l~~------------------~~~v~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (387) T 3I45_A 68 LLT------------------RHGVHALAGTFLSHVGLAVSDFARQRKVLFMASEPLTDALTWEKGNRYTYRLRPSTYMQ 129 (387) T ss_dssp HHH------------------HHCCSEEEECCSHHHHHHHHHHHHHHTCCEEECSCCCGGGTTTTCCTTEEECSCCHHHH T ss_pred HHH------------------HhCCCEEEEcCChHHHHHHHHHHHHcCCEEEEcCCCChhHhhcCCCCcEEEeCCCHHHH Confidence 332 14789999987776666667778888999998776554433222357788999988888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQ-KIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~-~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) +..+++++.+.+|+++++++.++.++..+.+.+++.+++. +..+.... .+.. ....+....+++++. .++|++++. T Consensus 130 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~-~~~~~~~~~~~~~~~-~~~~~ii~~ 206 (387) T 3I45_A 130 AAMLAAEAAKLPITRWATIAPNYEYGQSAVARFKELLLAA-RPEVTFVAEQWPA-LYKLDAGPTVQALQQ-AEPEGLFNV 206 (387) T ss_dssp HHHHHHHHTTSSCCEEEEECCSSHHHHHHHHHHHHHHHHH-CTTCEEEEEECCC-TTCCCHHHHHHHHHH-TCCSEEEEC T ss_pred HHHHHHHHhcCCCCEEEEEccCcHHhHHHHHHHHHHHHHh-CCCcEEEeeeccc-ccCCCcHHHHHHHHh-cCCCeEEEE Confidence 8899999888899999999976667777888888877764 22221111 1110 112344555666653 478888777 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ..+..+..+++++++.|+.....++ .......... .... ....+.+..... +. ....+....|. T Consensus 207 ~~~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~f~ 271 (387) T 3I45_A 207 LFGADLPKFVREGRVRGLFAGRQVV-SMLTGEPEYL-NPLKDEAPEGWIVTGYP----------WY---DIDTAPHRAFV 271 (387) T ss_dssp CCTTHHHHHHHHHHHHTSSTTCEEE-EEEEESHHHH-GGGGGGCCSSCEEEECC----------GG---GCCCHHHHHHH T ss_pred cccccHHHHHHHHHHcCccCCCeEE-EEecCCHHHH-HhhcCCCCCCeEEecCC----------cc---cCCCHHHHHHH Confidence 5566677888888888775311111 1111111000 0000 111222111000 00 00011111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+.+.+. ..+..++..+||++++++.|++++.. .+++ T Consensus 272 ~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~a~~~~~~---------------~~~~ 309 (387) T 3I45_A 272 EAYRARWK---------------------------EDPFVGSLVGYNTLTAMAVAFEKAGG---------------TESE 309 (387) T ss_dssp HHHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHH T ss_pred HHHHHHHC---------------------------CCCChHHHHHHHHHHHHHHHHHHhCC---------------CCHH Confidence 22222111 11234567899999999999988642 1345 Q NP_000836.2 441 ELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.++|++..|.|.+| ++.|++ +++....+.+.+++..+ +.+ .++.|... T Consensus 310 ~i~~~l~~~~~~g~~G-~i~f~~~~~~~~~~~~i~~~~~~~--g~~-~~~~w~~~ 360 (387) T 3I45_A 310 TLVETLKDMAFSTPMG-PLSFRASDHQSTMGAWVGRTALRD--GKG-VMVDWRYV 360 (387) T ss_dssp HHHHHTTTCEEEETTE-EEEBCTTTCBBCCCEEEEEEEEET--TEE-EEEEEEEE T ss_pred HHHHHHhhCcccCCCe-eEEEcCCCCcccccEEEEEEEeeC--Cce-eEeeeEEE Confidence 6778888778999988 899987 34444566776665321 233 34466543 No 100 >4F06_A Extracellular ligand-binding receptor; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: PHB, SO4, GOL; 1.3A {Rhodopseudomonas palustris} Probab=99.48 E-value=2.9e-18 Score=183.24 Aligned_cols=356 Identities=12% Similarity=0.097 Sum_probs=217.6 Template_Neff=12.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCS-RDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~-~~~~a~~~~~~~~ 120 (908) ..++++||++.|.++... ..+.....|++.|++++|. + ..|+++++.+.|+.+ ++.. ..+.+ T Consensus 2 ~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~--~-~~g~~~~~~~~d~~~~~~~~----~~~~~ 64 (371) T 4F06_A 2 NADTIKVGVIGTMSGPYA----------LFGKNYKMGIDAWVAEHGN--K-VAGHTVEFVYRDEVSPNPAQ----SKALA 64 (371) T ss_dssp --CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHCS--E-ETTEEEEEEEEECCSSCHHH----HHHHH T ss_pred cCCceEEEEEEcCCCChh----------HhHHHHHHHHHHHHHHcCC--c-cCCEEEEEEEecCCCCCHHH----HHHHH Confidence 356899999999875421 2556788899999999883 1 246778888877664 4332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++++++|++.++.....+...+...++|+|.+....+.+.. ..++++++.++.. T Consensus 65 ~~l~~------------------~~~~~~vi~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~--~~~~~~~~~~~~~ 124 (371) T 4F06_A 65 QELIV------------------KEKVQYLAGLYFTPNAMAVAPLLQEAKVPMVVMNAATSSITE--KSPYIVRTSFTMF 124 (371) T ss_dssp HHHHH------------------TSCCSEEEECCSHHHHHHHGGGHHHHTCCEEESSCCCGGGGG--GCTTEEESSCCHH T ss_pred HHHHH------------------hcCCCEEEeCCCCHHHHHHHHHHHHcCCCEEEecCCCchhcc--CCCCEEEecCchh Confidence 44332 157899999776666666677788899999998765543322 2567888888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..+..+++++.+.+|++|++++.++.++..+.+.+.+.+++. ++++.....+. ....+....+++++. .++|++++ T Consensus 125 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~ 200 (371) T 4F06_A 125 QNTVPAAKVAKQKGATKVAIAVSDYGPGIDAETAFKKTFEAE-GGKVVEAVRMP--LSTTDFGPIMQRIKN-SGADMIFT 200 (371) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HTCSEEEE T ss_pred hcHHHHHHHHHHhCCCEEEEEEeCCcccHHHHHHHHHHHHHC-CCEEcEEEEcC--CCCCChHHHHHHHHH-cCCCEEEE Confidence 888888888888899999999966667777788888887765 35544322222 122344556666653 47888877 Q NP_000836.2 281 FA-NEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW 358 (908) Q Consensus 281 ~~-~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 358 (908) .+ ++..+..+++++++.|+.. ++.|++.+.+...... ........+.+..... .. ....+.... T Consensus 201 ~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~----------~~---~~~~~~~~~ 266 (371) T 4F06_A 201 FLPAGPPTLGFVKAYIDNGLKAGGVKLMSTGDVVTEPDL-PNIGEAGLGILSTYHY----------AV---SHDSPENKA 266 (371) T ss_dssp ECCTTHHHHHHHHHHHHTTTTTTTCEEEEEGGGGCGGGH-HHHCGGGTTCEEEESC----------CT---TCCSHHHHH T ss_pred eCCCChhHHHHHHHHHHCCcccCCceEEEeCCCCCCcch-hhhhhhcceeEEEecc----------cc---cCCCHHHHH Confidence 65 4556778888988888753 3566665433221110 0011111222211100 00 000111122 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+++.+.. ...+..++..+||++++++++++++... .+ T Consensus 267 f~~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~al~~~~~~--------------~~ 307 (371) T 4F06_A 267 FLALLQKGGAK-------------------------LDEVTMTSVAAYDGARLIYKMIEATSGK--------------SD 307 (371) T ss_dssp HHHHHHHTTCC-------------------------GGGCCHHHHHHHHHHHHHHHHHHHTTTS--------------CC T ss_pred HHHHHHHcCCC-------------------------CCCCChHHHHHHHHHHHHHHHHHHcCCC--------------CC Confidence 33323221100 0012346778999999999999876421 23 Q NP_000836.2 439 GKELLGYIRAVNFNGSAGTPVTFNEN-GDAPGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 439 ~~~l~~~l~~~~f~G~~G~~v~Fd~~-G~~~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) ++.+.+.|++.+|.|.+| ++.|+++ +++...+.+.+++..++...++.++.|. T Consensus 308 ~~~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~ 361 (371) T 4F06_A 308 PDKAIAAVKGMKWVSPRG-EVSIDPETRHITQNVYLREVEKVDGKLINRELETFK 361 (371) T ss_dssp HHHHHHHHTTCEEEETTE-EEEECTTTCBEEEEEEEEEEEEETTEEEEEEEEEEE T ss_pred HHHHHHHHcCCCeecCCe-eEEEcccCCceeeeEEEEEEEeeCCEEEeeeeeecc Confidence 456778888888999888 8999974 4445677787776321123455555553 No 101 >4N03_A ABC-type branched-chain amino acid transport; structural genomics, fatty acid, PSI-Biology; HET: PLM; 1.15A {Thermomonospora curvata} Probab=99.46 E-value=4.8e-18 Score=184.10 Aligned_cols=356 Identities=14% Similarity=0.094 Sum_probs=221.3 Template_Neff=11.800 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||++.|.++... ..+.....+++.|++++|+.+++ .|+++++.+.|+.+++.. ..+. T Consensus 28 ~~~~~~i~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~g~~-~g~~i~~~~~d~~~~~~~----~~~~ 92 (405) T 4N03_A 28 GVTDKTIKLGIATDLTGVYA----------PLGKSITQAQQLYYEEVNQRGGV-CGRTIEAVVRDHGYDPQK----AVSI 92 (405) T ss_dssp TBCSSEEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTCB-TTBEEEEEEEECTTCHHH----HHHH T ss_pred CcCCCeEEEEEEeCCCCCCc----------chhHHHHHHHHHHHHHHHHcCCc-CCEeEEEEEEeCCCCHHH----HHHH Confidence 45678999999999875321 24567889999999999987654 367888888887655332 2233 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++ ++++++|++.++.....+...+...++|+|....... .. ..++++++.+++ T Consensus 93 ~~~l~--------------------~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~-~~---~~~~~~~~~~~~ 148 (405) T 4N03_A 93 YTELN--------------------NNVLAIPHFLGSPMVSAVKQRIESDKMFTIPSAWTTA-LL---GSKYIQVTGTTY 148 (405) T ss_dssp HHHHT--------------------TTCSCEEEEECHHHHHHHHHHHHHHTCCEEEECCCGG-GC---SCTTBCCCSCCH T ss_pred HHHHH--------------------hhccEEeeccCChhHHHHHHHHHhcCCceecccccHH-Hc---CCCccccCCCCH Confidence 33322 2678888877666666666777888999986543322 11 246778888888 Q NP_000836.2 200 SYQAQAMVDIVTAL----GWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNA 275 (908) Q Consensus 200 ~~~~~~~~~~l~~~----~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 275 (908) ...+..+++++.+. +|++|++++.++.++..+.+.|++.+++. ++++.. ..+. ....++...+++++. .++ T Consensus 149 ~~~~~~~~~~l~~~~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~-~~~~--~~~~~~~~~~~~~~~-~~~ 223 (405) T 4N03_A 149 DVDMINGVQWLMDKKLIKKGDKLGHVYFEGDYGGSALRGTKYAAEQL-GLEVFE-LPIK--PTDRDMKSQVAALAK-EKV 223 (405) T ss_dssp HHHHHHHHHHHHHTTSSCTTCEEEEEEETTHHHHHHHHHHHHHHHHH-TCEEEE-EEEC--TTCCCCHHHHHHHHH-TTC T ss_pred HHHHHHHHHHHHHccccCCCCEEEEEEecCcchhhHHHHHHHHHHHh-CCEEEE-eeeC--CCCCCHHHHHHHHHH-CCC Confidence 88888888887543 89999999976667777788888888765 355432 2221 122345566677763 578 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE--EIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~--~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) |+|++...+..+..+++++++.|+. ..|++.+.+...... .... ....+.+....... . .... T Consensus 224 ~~vv~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~g~~~~~~~~~---------~---~~~~ 288 (405) T 4N03_A 224 DAILLSAGPQQAASLAGIARSQGMK--QPILGSNSAYSPQLL-ATPAKPALVEGFFIATAGAP---------M---SADL 288 (405) T ss_dssp SEEEEESCHHHHHHHHHHHHHTTCC--CCEEECTTSCCGGGG-GSTTHHHHSSSEEEEESSCC---------T---TSSC T ss_pred CEEEEecCHHHHHHHHHHHHHcCCC--CCEEEecccCCHHHh-cCCCchhhcCCEEEEecCCC---------C---CCCC Confidence 8887776666677888888887773 456665533221110 0000 11222221111000 0 0001 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPR 433 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~ 433 (908) +....|.+.+++.+.. .....++..+||++++++++++++.... T Consensus 289 ~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~al~~~~~~~---------- 332 (405) T 4N03_A 289 PAIKKLAEAYSKKYPK--------------------------DPLDSGVVNGYGGASIVVSALEKACANK---------- 332 (405) T ss_dssp HHHHHHHHHHHHHCTT--------------------------SCCCHHHHHHHHHHHHHHHHHHHHHHTT---------- T ss_pred HHHHHHHHHHHHHCCC--------------------------CCCChHHHHHHHHHHHHHHHHHHHHHCC---------- Confidence 1112222222222110 0113457789999999999999875311 Q NP_000836.2 434 MSTIDGKELLGYIRAV-NF-NGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 434 ~~~~~~~~l~~~l~~~-~f-~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..+++.+.+.|++. .| .|.+| ++.|+.+|++ ...+.|++++..+ ...++.||.|... T Consensus 333 --~~~~~~l~~~l~~~~~~~~g~~g-~i~f~~~g~~~~~~~~i~~~~~~~-~~~~~~v~~~~~~ 392 (405) T 4N03_A 333 --DLTREGLINAHRSEANADDGLGT-PMNFTYFDKPATRKTYIIKPDEKA-TGGAVIVEQAFES 392 (405) T ss_dssp --EESHHHHHHHHTTCSCBCCSSSC-CBCCSCCSSCSCCCEEEEEECTTS-GGGEEEEEEEECC T ss_pred --CCCHHHHHHHHhcccCCCCCCCC-ccccccCCCCCcccEEEEEeCCCC-CCceEEEeeeecc Confidence 12455677788765 57 68888 8999988876 4578888886432 3468899999765 No 102 >4M88_A Extracellular ligand-binding receptor; STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER; HET: GOL; 1.762A {Verminephrobacter eiseniae} Probab=99.46 E-value=4.9e-18 Score=180.42 Aligned_cols=343 Identities=14% Similarity=0.064 Sum_probs=212.0 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.++... ..+.....|++.|++++|+.+++. |+++++.+.|+.+++.. ..+.+++ T Consensus 2 ~~~i~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~i~~~~~d~~~~~~~----~~~~~~~ 66 (357) T 4M88_A 2 NAQIVLGQIGPFTGPLA----------ADAAGLNQGIKAYLAQANKAGGIR-GQKLTLFEADDRFSGEG----FAEQFPK 66 (357) T ss_dssp -CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHHTTCBT-TBEEEEEEEECTTSHHH----HHHHHHH T ss_pred CCeEEEeEEecCCCCCh----------HHhHHHHHHHHHHHHHHHHcCCCC-CEEeEEEEEcCCCCHHH----HHHHHHH Confidence 46789999999876421 245678899999999999876654 77888888887665432 3333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVAN--ILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~--~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++. ++++++|++.++.....+.. .+...++|+|++....+.+.. ..+++++++.++.. T Consensus 67 ~~~-------------------~~v~~iig~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~-~~~~~~~~~~~~~~ 126 (357) T 4M88_A 67 AME-------------------KKPLALISPMGSAAIKRMLDDKLLDTAPVVVVNGVPGAESLRT-PGHPKFFHVRAGDK 126 (357) T ss_dssp HHT-------------------TCCSEEECCBCHHHHHHHHHTTTTSSCSCEEECCBSCCHHHHS-SCCTTEEBCSCCHH T ss_pred HHh-------------------hCCCEEEeCCCcHHHHHHcchhHHhcCCcEEEECCCCchhhcC-CCCCCeEEccCCcH Confidence 332 47889998877666555555 678889999988765544332 23577899999998 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISRE-IGGVCIAQ-SQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~-~~~i~v~~-~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+|+++++++.++.++..+.+.|++.+++ . ++.+.. ...+. .+..+....+++++. .++|+| T Consensus 127 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~-g~~i~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i 202 (357) T 4M88_A 127 QEIEEIVSHAQMLGMSKLATLYQDLPTGTSGMAVVQEAVKTVP-GGKIELNGVKSG--PDAAALAAAARQIAA-LGAQGV 202 (357) T ss_dssp HHHHHHHHHHHHTTCSEEEEEEESSHHHHHHHHHHHHHHHTCT-TCCCEEEEEEEC--SSHHHHHHHHHHHHT-TTCSEE T ss_pred HHHHHHHHHHHHhCCCEEEEEEeCChhcHHHHHHHHHHHHcCC-CCceEEEEeecC--CCHHHHHHHHHHHHH-cCCCEE Confidence 88999999988889999999997667787888888888776 4 344431 11111 122345556666663 578888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) ++...+..+..+++++++.|+. ..|++.+.+...... .... ....+.+....... .. ....+... T Consensus 203 i~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~--------~~---~~~~~~~~ 268 (357) T 4M88_A 203 LVIGPPPFIVAGIAALRKADVT--QPLFVLSYVSAAQIV-KVVGVAGARGVGIVQAFPD--------PN---DKMLPVQR 268 (357) T ss_dssp EEESSHHHHHHHHHHHHHTTCC--SCEEECTTCCHHHHH-HHHHHHHHTTEEEEESSSC--------TT---CCSSHHHH T ss_pred EEECCHHHHHHHHHHHHhCCCC--CCEEEeecCCHHHHH-HHHcccCcceEEEEEEeCC--------cc---cCCCHHHH Confidence 7777666677888998888874 345554433221110 0000 11122221110000 00 00011122 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) .|.+.+++.++. ...+..++..+||+++++++|++++... .. T Consensus 269 ~f~~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~al~~~~~~-------------~~ 310 (357) T 4M88_A 269 EFQAAMKEAFPQ-------------------------MQEYTEFQLEGYLSARTVGEALKHPKNT-------------GL 310 (357) T ss_dssp HHHHHHHHHCTT-------------------------CCSCCHHHHHHHHHHHHHHHHHHSTTCC-------------CS T ss_pred HHHHHHHHHccc-------------------------cCCCChHHHHHHHHHHHHHHHHhccCCC-------------CC Confidence 233333322210 0112346788999999999999886421 12 Q NP_000836.2 438 DGKELLGYIRAV-NFNGSAGTPVTFNENGDAPGRYDIFQYQ 477 (908) Q Consensus 438 ~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~~~~~i~~~~ 477 (908) +++.+.++|++. .|. .+|.++.|+++|++...+.+.++. T Consensus 311 ~~~~l~~~l~~~~~~~-~~G~~~~f~~~~~~~~~~~i~~~~ 350 (357) T 4M88_A 311 SAANLAATLSTMGEID-IGGFHLDFSKGNAGSRYVNIGVIG 350 (357) T ss_dssp SHHHHHHHHHHSCCEE-ETTEEECCSSSSBCCCCCEEEEEC T ss_pred CHHHHHHHHHcCCCcc-cCcEEeecCCCCCccCcEEEEEEc Confidence 455677778765 465 334268999877766677777774 No 103 >3I09_B Periplasmic branched-chain amino acid-binding protein; TYPE I PERIPLASMIC BINDING PROTEIN; HET: MSE, CIT, EDO, AAE; 1.8A {Burkholderia mallei} Probab=99.45 E-value=6.2e-18 Score=181.03 Aligned_cols=347 Identities=10% Similarity=0.101 Sum_probs=213.9 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++... ...+.....+++.|++++|. + +.|+++++.+.|+.+++. ...+.+++ T Consensus 2 ~~~~~Ig~i~~~~~~~~---------~~~~~~~~~g~~~a~~~~~~--~-~~g~~i~~~~~d~~~~~~----~~~~~~~~ 65 (375) T 3I09_B 2 ADSVKIGFITDMSGLYA---------DIDGQGGLEAIKMAVADFGG--K-VNGKPIEVVYADHQNKAD----IAASKARE 65 (375) T ss_dssp CSSEEEEEEECSSSTTT---------TTSHHHHHHHHHHHHHHHTS--E-ETTEEEEEEEEECTTCHH----HHHHHHHH T ss_pred CCeeEEEEEeCCCCcch---------hhcchhHHHHHHHHHHHhCC--c-cCCEEEEEEEecCCCCHH----HHHHHHHH Confidence 46789999999875421 01356778899999999872 2 346778888888765533 22333444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++++++|++.++.....+...+...++|+|.+....+.+.....+++++++.+++... T Consensus 66 l~~------------------~~~v~~vi~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 127 (375) T 3I09_B 66 WMD------------------RGGLDLLVGGTNSATALSMNQVAAEKKKVYINIGAGADTLTNEQCTPYTVHYAYDTMAL 127 (375) T ss_dssp HHH------------------HSCEEEEEECSCHHHHHHHHHHHHHHTCEEEECSCCCGGGGTTTCCTTEEECSCCHHHH T ss_pred HHH------------------hCCCCEEEecCChHHHHHHHHHHHHcCCEEEEccCCccccCCCcCCCceeEecCCHhHH Confidence 332 15788999977766666667778889999999876655433222346778888888888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++.+++++.+.+|+++++++.++.++..+.+.+.+.+++. ++++.....+. .+..++...++++.. .++|++++.. T Consensus 128 ~~~~~~~l~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~~~ 203 (375) T 3I09_B 128 AKGTGSAVVKQGGKTWFFLTADYAFGKALEKNTADVVKAN-GGKVLGEVRHP--LSASDFSSFLLQAQS-SKAQILGLAN 203 (375) T ss_dssp CCCCCHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-TTCSEEEEEC T ss_pred HHHHHHHHHHcCCCEEEEEEeCcHHHHHHHHHHHHHHHHC-CCEEEEEEeCC--CCccchHHHHHHHHh-cCCCEEEEEe Confidence 8899998877899999999976667778888888888775 35544322222 122345556666653 4788887776 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQ-EEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~-~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) .+..+..+++++++.|+...+ ++.......... ... .....+.+.... +.. ...+....|.+ T Consensus 204 ~~~~~~~~~~~l~~~g~~~~~-~~~~~~~~~~~~--~~~~~~~~~~~~~~~~----------~~~----~~~~~~~~f~~ 266 (375) T 3I09_B 204 AGGDTVNAIKAAKEFGITKTM-KLAALLMFINDV--HALGLETTQGLVLTDS----------WYW----NRDQASRQWAQ 266 (375) T ss_dssp CHHHHHHHHHHHHHTTGGGTC-EEEESSCCHHHH--HHHCHHHHTTCEEEES----------CCT----TSSHHHHHHHH T ss_pred cchHHHHHHHHHHHcCCCCCe-eEeeccccHHHH--HHcCHhHHcCceEeec----------ccc----CCCHHHHHHHH Confidence 666778899999888875322 232211111000 000 011122211110 000 00111122333 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) .+++.++ ..++.++..+|||++++++|++++.. .++.. T Consensus 267 ~~~~~~~---------------------------~~p~~~~~~~yda~~~~~~al~~~~~---------------~~~~~ 304 (375) T 3I09_B 267 RYFAKMK---------------------------KMPSSLQAADYSSVTTYLKAVQAAGS---------------TDSDK 304 (375) T ss_dssp HHHHHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTS---------------CCHHH T ss_pred HHHHHHC---------------------------CCCCHHHHHHHHHHHHHHHHHHHhCC---------------CCHHH Confidence 2322221 11235677899999999999988642 13456 Q NP_000836.2 442 LLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 442 l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) +.++|++..|.|.+| .+.|+.+|++...+.+.+++.+ . ..+|.|. T Consensus 305 ~~~~l~~~~~~~~~~-~~~~~~~g~~~~~~~i~~~~~~----~-~~~~~~~ 349 (375) T 3I09_B 305 VMAQLKKMKIDDFYA-KGYIRTDGSMIHDMYLMEVKKP----S-ESKEPWD 349 (375) T ss_dssp HHHHHTTSCEESSSC-EEEECTTSBEECCEEEEEECCG----G-GCCSTTC T ss_pred HHHHHhcCCccccCC-ceEEecCCCeEeeEEEEEEeCC----C-CCCCCcc Confidence 778888777877555 6777777877777888887631 1 4555565 No 104 >5TQ0_B NMDA glutamate receptor subunit, Glutamate; ION CHANNEL, NMDA RECEPTOR, ALLOSTERIC; HET: GOL, NAG, SO4; 2.7A {Mus musculus} Probab=99.45 E-value=6.5e-18 Score=179.74 Aligned_cols=343 Identities=16% Similarity=0.212 Sum_probs=207.3 Template_Neff=11.700 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR---ILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~---~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++||+++|.++.. +.+.|++++|+. .++|+++++. +.|+.+++..+. +.+++ T Consensus 1 i~ig~i~~~sg~~-------------------~~~~~~~~~n~~--~~~~~~v~l~~~~~~d~~~~~~~~~----~~~~~ 55 (360) T 5TQ0_B 1 LNIAVLLGHSHDV-------------------TERELRNLWGPE--QATGLPLDVNVVALLMNRTDPKSLI----THVCD 55 (360) T ss_dssp CEEEEEECSSSCC-------------------CCCCC--------------CSCCEEEEEECSCCSHHHHH----HHHHH T ss_pred CeEEEEecCCCCh-------------------hHHHHHHccCcc--ccCCCCcEEEEEEeecCCCCHHHHH----HHHHH Confidence 5799999987631 235577788864 2457777774 477766644333 33333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKI-SGVIGAAASSVS--IMVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v-~~vIg~~~s~~~--~~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~ 198 (908) ++.. +++ ++++|+.++..+ ..++.++...++|+|++.+..+.+.. ...+++++++.|+ T Consensus 56 l~~~------------------~~v~~~vig~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (360) T 5TQ0_B 56 LMSG------------------ARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGAS 117 (360) T ss_dssp HHHT------------------TCCSEEEEECCSCCTHHHHHHHHHHHHHCCCEEEEEGGGGCCCSCCCTTCCEEESCCC T ss_pred HHcC------------------CCceEEEEcCCCChHHHHHHHHHHHhhcCCCEEEecCCCcccccCCCCCCceEeecCC Confidence 3321 456 678898877665 67788889999999998876654432 2247899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ...+++++++++.+++|+++++++.++.++....+.+++.+++.+ ++++.....++ ....++. .+++++. .++++ T Consensus 118 ~~~~~~~l~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~-~~~~i~~-~~~~~ 193 (360) T 5TQ0_B 118 IQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLD--TSFEDAK-TQVQLKK-IHSSV 193 (360) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHSSSCCEECCCEEES--CSSCTHH-HHHHHTT-CCCSE T ss_pred HHHHHHHHHHHHHHcCCeEEEEEEecCCchHHHHHHHHHHHhcCCCcceeEEEEEec--CCcccHH-HHHHHhc-CCCeE Confidence 988899999999888999999999887788877788887776542 13443322232 1223455 6666663 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.........+++++++.|+.. .+.|+..+.+...... .......+.+. T Consensus 194 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~-------------------------- 245 (360) T 5TQ0_B 194 ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTEL--IPKEFPSGLIS-------------------------- 245 (360) T ss_dssp EEEECCHHHHHHHHHHHHHTTCSSTTSEEEECHHHHCSTTC--CCTTSCTTCEE-------------------------- T ss_pred EEEEcCHHHHHHHHHHHHHcCCCCCCEEEEeecccCCCCcC--CCccCCCceEE-------------------------- Confidence 888777777888999988888753 3567765433221100 00000001000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP--GYIGLCPRM 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~--~~~~~~~~~ 434 (908) + . +. .+ ...++..+|||++++++|++++....+. .....|... T Consensus 246 --~-~-~~-~~------------------------------~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~c~~~ 290 (360) T 5TQ0_B 246 --V-S-YD-DW------------------------------DYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCYGQ 290 (360) T ss_dssp --E-E-SC-CS------------------------------SSCHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCSCSSCC T ss_pred --E-E-ec-Cc------------------------------cccHHHHHHHHHHHHHHHHHHHHHhcCCCCccccccccc Confidence 0 0 00 00 0124567999999999999987543210 001223211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ....+..+.+.|++..|.|. .+.||++|++. ..+.+++++. ...++.||.|+... +....+.|+ T Consensus 291 ~~~~~~~~~~l~~~l~~~~~~G~---~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 358 (360) T 5TQ0_B 291 AEKPETPLHTLHQFMVNVTWDGK---DLSFTEEGYQVHPRLVVIVLNK---DREWEKVGKWENQT-LSLRHAVWP 358 (360) T ss_dssp -----CCSCCSTTTSSSCEETTE---ECCBCTTSSBSSCCCEEEEECT---TSCEEEEEECTTTT-CCBCCC--- T ss_pred CCCCCChHHHHHHHHcceeEcCe---eeEECCCCceeceEEEEEEeeC---CCceEEEEEEECCe-eEecceecC Confidence 11245567788888888875 69999999885 6788888873 15789999998762 322335563 No 105 >5TPW_B NMDA glutamate receptor subunit, Glutamate; ION CHANNEL, NMDA RECEPTOR, ALLOSTERIC; HET: NAG, GOL, SO4; 2.909A {Mus musculus} Probab=99.45 E-value=6.5e-18 Score=179.74 Aligned_cols=343 Identities=16% Similarity=0.212 Sum_probs=203.3 Template_Neff=11.700 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR---ILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~---~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++||+++|.++.. +.+.|++++|+. .++|+++++. +.|+.+++..+. +.+++ T Consensus 1 i~ig~i~~~sg~~-------------------~~~~~~~~~n~~--~~~~~~v~l~~~~~~d~~~~~~~~~----~~~~~ 55 (360) T 5TPW_B 1 LNIAVLLGHSHDV-------------------TERELRNLWGPE--QATGLPLDVNVVALLMNRTDPKSLI----THVCD 55 (360) T ss_dssp CEEEEEECSTTCC-------------------CC-------------------CCEEEEEECCCCSHHHHH----HHHHH T ss_pred CeEEEEecCCCCh-------------------hHHHHHHccCcc--ccCCCCcEEEEEEeecCCCCHHHHH----HHHHH Confidence 5799999987631 235577788864 2457777774 477766644333 33333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKI-SGVIGAAASSVS--IMVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v-~~vIg~~~s~~~--~~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~ 198 (908) ++.. +++ ++++|+.++..+ ..++.++...++|+|++.+..+.+.. ...+++++++.|+ T Consensus 56 l~~~------------------~~v~~~vig~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (360) T 5TPW_B 56 LMSG------------------ARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGAS 117 (360) T ss_dssp HHTT------------------SCCSEEEEECSSCCTHHHHHHHHHHHHHCCCEEEEEGGGGCCCSCCCTTCCEEESCCC T ss_pred HHcC------------------CCceEEEEcCCCChHHHHHHHHHHHhhcCCCEEEecCCCcccccCCCCCCceEeecCC Confidence 3321 456 678898877665 67788889999999998876654432 2247899999999 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ...+++++++++.+++|+++++++.++.++....+.+++.+++.+ ++++.....++ ....++. .+++++. .++++ T Consensus 118 ~~~~~~~l~~~~~~~~~~~v~iv~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~-~~~~i~~-~~~~~ 193 (360) T 5TPW_B 118 IQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLD--TSFEDAK-TQVQLKK-IHSSV 193 (360) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEECSSTTHHHHHHHHHHHHHTSTTCSEECCCEECC--TTSCHHH-HHHHHTT-CCCSE T ss_pred HHHHHHHHHHHHHHcCCeEEEEEEecCCchHHHHHHHHHHHhcCCCcceeEEEEEec--CCcccHH-HHHHHhc-CCCeE Confidence 988899999999888999999999887788877788887776542 13443322232 1223455 6666663 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.........+++++++.|+.. .+.|+..+.+...... .......+.+. T Consensus 194 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~~-------------------------- 245 (360) T 5TPW_B 194 ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTEL--IPKEFPSGLIS-------------------------- 245 (360) T ss_dssp EEEESCHHHHHHHHHHHHHTTCSSTTSEEEECHHHHCCSSC--CCTTSCTTCEE-------------------------- T ss_pred EEEEcCHHHHHHHHHHHHHcCCCCCCEEEEeecccCCCCcC--CCccCCCceEE-------------------------- Confidence 888777777888999988888753 3567765433221100 00000001000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP--GYIGLCPRM 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~--~~~~~~~~~ 434 (908) + . +. .+ ...++..+|||++++++|++++....+. .....|... T Consensus 246 --~-~-~~-~~------------------------------~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~c~~~ 290 (360) T 5TPW_B 246 --V-S-YD-DW------------------------------DYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCYGQ 290 (360) T ss_dssp --E-E-SC-CT------------------------------TSCHHHHHHHHHHHHHHHHHHTTTSSSSCCCCCSCSCC- T ss_pred --E-E-ec-Cc------------------------------cccHHHHHHHHHHHHHHHHHHHHHhcCCCCccccccccc Confidence 0 0 00 00 0124567999999999999987543210 001223211 Q NP_000836.2 435 ---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWA 505 (908) Q Consensus 435 ---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~~~~~~i~w~ 505 (908) ....+..+.+.|++..|.|. .+.||++|++. ..+.+++++. ...++.||.|+... +....+.|+ T Consensus 291 ~~~~~~~~~~l~~~l~~~~~~G~---~i~f~~~g~~~~~~~~i~~~~~---~~~~~~vg~w~~~~-l~~~~~~w~ 358 (360) T 5TPW_B 291 AEKPETPLHTLHQFMVNVTWDGK---DLSFTEEGYQVHPRLVVIVLNK---DREWEKVGKWENQT-LSLRHAVWP 358 (360) T ss_dssp -----CCSCCSSTTTSSCEETTE---ECCBCTTSSBSSCCCEEEEEET---TTEEEEEEECTTTT-CCCCC---- T ss_pred CCCCCChHHHHHHHHcceeEcCe---eeEECCCCceeceEEEEEEeeC---CCceEEEEEEECCe-eEecceecC Confidence 11245567788888888875 69999999885 6788888873 15789999998762 322335563 No 106 >4MAA_A Putative branched-chain amino acid ABC; Psi-Biology, MCSG, Midwest Center For; HET: GOL; 2.0A {Pseudomonas protegens} Probab=99.44 E-value=9.1e-18 Score=181.66 Aligned_cols=352 Identities=13% Similarity=0.078 Sum_probs=215.8 Template_Neff=12.000 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.++... ..+.....|++.|++++|.. .|.++++.+.|+.+++.. ..+. T Consensus 29 ~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~~~----~g~~i~~~~~d~~~~~~~----~~~~ 90 (403) T 4MAA_A 29 AFAAEPFTFYGLKSMSGAFA----------SYGKFADMGSRLAVEQYPTL----LGRPLHYKVIDTEGNAGK----AVRR 90 (403) T ss_dssp -CCCCCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHTCSEE----TTEEEEEEEEECTTCHHH----HHHH T ss_pred hhhCCCEEEEEEecCCCCch----------hhhHHHHHHHHHHHHhcCcc----CCeeeEEEEEeCCCCHHH----HHHH Confidence 45678999999999875321 25667889999999999842 366788888887655432 3333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV-PP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~-~~ 198 (908) +++++. .++++++|++.++.....+...+...++|+|.+.. .+.+.....+++++++. ++ T Consensus 91 ~~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~-~~~~~~~~~~~~~~~~~~~~ 151 (403) T 4MAA_A 91 VQEAIA------------------QDGARFFQGCTLSSSALAVAKEVGKVGGVFMTPVG-ADEITGKDCNASTFRWSVPT 151 (403) T ss_dssp HHHHHH------------------HHCCCEEEECSSHHHHHHHHHHHHHHTCEEEECCC-CGGGGTTTCCTTEEECSCCH T ss_pred HHHHHH------------------hcCCCEEEecCCcHHHHHHHHHHHhhCCEEEccCC-ccccCCCCCCCceeEeeCCc Confidence 444332 15788999987776666777778889999998875 33222211256777875 66 Q NP_000836.2 199 DSYQAQAMVDIVTA-LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 199 ~~~~~~~~~~~l~~-~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ....++.+++++.+ .+|++|++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|+ T Consensus 152 ~~~~~~~~~~~l~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~d~ 227 (403) T 4MAA_A 152 YGAIRETMVPLIKLLPEAKRWYTITPQYVFGEALLEGAKQVCAEH-GIEHIGNSYHS--LQEQEFSGYLTNAIA-ARPDV 227 (403) T ss_dssp HHHHHHHHHHHHHHCTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-TCEEEEEEEEC--TTCCCCHHHHHHHHH-HCCSE T ss_pred HHHHHHhhHHHHHhCCCCCEEEEEEeCCHHHHHHHHHHHHHHHHC-CCEEEEEEEec--CCCCChHHHHHHHHH-hCCCE Confidence 66677788888866 589999999976677778888888888765 35544332222 122345556666653 57888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 357 (908) +++...+..+..+++++++.|+..++.+++.+....... .........+.+..... +.. ...+... T Consensus 228 v~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~~~---~~~~~~~ 293 (403) T 4MAA_A 228 LVLLNFGSQSSNALRQAVNFGIKERMKVLLVWSAGLDQF-QELGSDVLEGVYLGAQY----------WHQ---VDTPLNR 293 (403) T ss_dssp EEECCCHHHHHHHHHHHHHHTHHHHSEEEESSCCTHHHH-HHHHHHHHBTCEEEESC----------CTT---CCCHHHH T ss_pred EEEECCchHHHHHHHHHHHCCCccCcEEEEeccccHHHH-HHHchhhhcCcEEEecc----------ccc---CCCHHHH Confidence 877765566778888888888753333444322111100 00000112222211100 000 0011112 Q NP_000836.2 358 WFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTI 437 (908) Q Consensus 358 ~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~ 437 (908) .|.+.+++.++ ..++.++..+||++++++++++++.. . T Consensus 294 ~f~~~~~~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~---------------~ 331 (403) T 4MAA_A 294 ELVKLTQAKYG---------------------------INPTYPLAADYIGSKIILDTIAATGS---------------F 331 (403) T ss_dssp HHHHHHHHHTS---------------------------SCCCHHHHHHHHHHHHHHHHHHHHTC---------------C T ss_pred HHHHHHHHHHC---------------------------CCCChhHHHHHHHHHHHHHHHHHHCC---------------C Confidence 23333322221 11234567899999999999988642 2 Q NP_000836.2 438 DGKELLGYIRAVNFNGSAGTPVTFNE-NGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 438 ~~~~l~~~l~~~~f~G~~G~~v~Fd~-~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ++..+.++|++..|.|.+| .+.||+ +++....+.+++++. .. ..+|.|+.. T Consensus 332 ~~~~l~~~l~~~~~~g~~g-~~~f~~~~~~~~~~~~i~~~~~----~~-~~~~~w~~~ 383 (403) T 4MAA_A 332 DGATVAKAMQGLTYQGPTG-EESIRAGDHQVIKDYYLLVGKA----AA-TMRDKDDLA 383 (403) T ss_dssp CHHHHHHHHTTCEEEETTE-EEEECTTTCBEECCEEEEEECC----GG-GCSSTTCCE T ss_pred CHHHHHHHHcCCceecCCe-eEEeCCCCCeeeeeEEEEEeec----cc-ccCCHhHHH Confidence 3456778888888999988 899997 334445677777762 22 567888755 No 107 >5L1B_D Glutamate receptor 2; Transporter, fusion protein, MEMBRANE PROTEIN; HET: NAG; 4.0A {Rattus norvegicus} Probab=99.43 E-value=1.1e-17 Score=198.82 Aligned_cols=356 Identities=15% Similarity=0.203 Sum_probs=224.6 Template_Neff=11.600 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||++.|.++. ....|++.|++++|++ |+++++.+.|+. +++. .+.+.+++ T Consensus 1 ~~i~Ig~~~~~~~~----------------~~~~g~~~a~~~in~~-----g~~i~~~~~d~~~~~~~----~~~~~~~~ 55 (803) T 5L1B_D 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSF----AVTNAFCS 55 (803) T ss_dssp CEEEEEEEEESSCS----------------HHHHHHHHHHHHTCCS-----SCEEEEEEEEECTTCHH----HHHHHHHH T ss_pred CceeeEeeeCCCCh----------------HHHHHHHHHHHhhcCC-----CceeeeeeEecCCCCHH----HHHHHHHH Confidence 36889999998752 4668999999999975 467888888865 3332 22233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +.. +++++++|+.++..+..++.++...++|++++..+++ ..+++++++.++ . T Consensus 56 l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~ 108 (803) T 5L1B_D 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---L 108 (803) T ss_dssp HHH-------------------TTCSEEECCCCTTTHHHHHHHHHHSCCEEEECSCCCS-----SCCSSEEECSCC---C T ss_pred HHh-------------------cCeeEEEecCChHHHHHHHHHHcccCCcEEeCCCCCC-----CCCCeEEEecCC---h Confidence 332 5789999998887777888888899999998876443 247889999988 5 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++++++++++++|+++++++ +++++....+.+.+.+++. ++++.....++. +.+..++...++++++ .++++|++ T Consensus 109 ~~~~~~~l~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-~~~i~~~~~~~~~~~~~~~d~~~~~~~i~~-~~~~~i~~ 185 (803) T 5L1B_D 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (803) T ss_dssp HHHHHHHHHHTTCSEEEEEE-CSTTCSHHHHHHHHHHHHH-TCEEEEEECSCCCSSSHHHHHHHHHHHHGG-GTCCCEEE T ss_pred HHHHHHHHHHhCCCEEEEEE-eCcchHHHHHHHHHHHhhc-CCeEEEEEccCCCCCCCcchhHHHHHHHHh-cCCeEEEE Confidence 77888888888999999999 5567777777777777664 355544322210 0122456677777763 57899888 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..+++++++.|+.. .+.|++.+.+...... ........+...... .. ...+....+ T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~-----------~~----~~~~~~~~f 249 (803) T 5L1B_D 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQI-----------VD----YDDSLVSKF 249 (803) T ss_dssp ESCHHHHHHHHHHHHHTTCCBTTCEEEECSSBTTTSCC-SSSSSSBCEEEEEEC-----------SC----SSSHHHHHH T ss_pred ECCHHHHHHHHHHHHHcCCCCCCcEEEEEeCCCCccch-hhcccCCeeEEEEEE-----------Ee----CCchHHHHH Confidence 877777888999999888754 3567765432211100 000000111111100 00 011112233 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.+++. +... ....+..++..+|||++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~-------------~~~~------~~~~~~~~~~~~yda~~~~a~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (803) T 5L1B_D 250 IERWSTLEEKE-------------YPGA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (803) T ss_dssp HHHHTTSCTTT-------------STTC------SSSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCSSCCCCTTCSS T ss_pred HHHHHhcchhh-------------CCCc------ccCCCchHHHHHHHHHHHHHHHHHHHHHhccccccCCCCCCcccCC Confidence 33343332210 0000 00123456788999999999999988653210 000122110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.+.|++..|.|.+| ++.|+++|++.. .+.+++++ ++.++.+|.|+.. T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~i~f~~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~ 368 (803) T 5L1B_D 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (803) T ss_dssp CCCCTHHHHHHHHHTTCCCEETTE-ECEECSSCCEESCCEEEEEEC----SSSEEEEEEEETT T ss_pred CCCccccHHHHHHHHhcCccCCCc-cEEECCCCcEEEEEEEEEEec----cCCceEEEEEecC Confidence 1124567888888889999988 899999898764 78888887 2467888888854 No 108 >4TLL_D GluN1/GluN2B; Neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: QEM, JEG, NAG; 3.59A {Xenopus laevis} Probab=99.42 E-value=1.3e-17 Score=198.99 Aligned_cols=340 Identities=15% Similarity=0.200 Sum_probs=214.1 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD--LLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~--il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ...+++++||+++|.++ . ++|++++|++++ ++++..+.+...|+.+++..+.+. T Consensus 5 ~~~~~~i~Ig~~~p~sg--------------~--------~~a~~~~n~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~-- 60 (824) T 4TLL_D 5 AQKHPNMDIAVILVGTT--------------E--------EVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITR-- 60 (824) T ss_dssp ---CCEEEEEEEEECCS--------------S--------CCCTTC-------CCCSSEEEEEEEEESCCCHHHHHHH-- T ss_pred cccCCCceEEEEEcCCC--------------h--------HHhhhccccCCCcccCCCCceeEEEeCCCCCHHHHHHH-- Confidence 45567899999999763 1 889999998876 455665667777777665443333 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASS--VSIMVANILRLFKIPQISYASTAPE-LSDNTRYDFFS 193 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~--~~~~va~~~~~~~iP~Is~~~~~~~-l~~~~~~~~~~ 193 (908) +.+++. ++++++++ |+.++. ....++..+...++|++++....+. +++...+++++ T Consensus 61 --~~~l~~------------------~~~v~~vv~G~~~s~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~ 120 (824) T 4TLL_D 61 --ICDLMS------------------DKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFF 120 (824) T ss_dssp --HHHHHT------------------TTCEEEEEEECCCCCTHHHHHHHHHHHHHTCCEEECSGGGGSCCSCCCTTCCEE T ss_pred --HHHHhc------------------cCCCEEEEEcCCCChHHHHHHHHHHHHhhCCCEEEecCCCccccccccccceEE Confidence 333332 15789987 988776 4456677778899999986554432 22233578999 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) ++.+++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.......... ...+....++++++ T Consensus 121 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~- 198 (824) T 4TLL_D 121 QFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENS-FVGWELEEVIHLDMSLDDIDSKIQNQLCK- 198 (824) T ss_dssp ESSBCHHHHHHHHHHHHHHTTCCEEEEEEESSTTHHHHHHHHHHHHHHC-CBCCEEEEEEEECTTSCCSSCHHHHHHTT- T ss_pred ecCCCHHHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHHhc-cCCcEEEEEEEecCChhhhhHHHHHHHHh- Confidence 9999999999999999988899999999988888888888888877764 34433221111101 11223444555653 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .++|+|++......+..+++++++.|+.+ .+.|+..+.|...... .......+.+ T Consensus 199 ~~~~~iv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~---------------------- 254 (824) T 4TLL_D 199 LQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDT--VPDEFPTGLI---------------------- 254 (824) T ss_dssp CCSSEEEEECCHHHHHHHHHHHHHHTTTSTTCEEECCTTTCCCSSC--CCTTSCTTCE---------------------- T ss_pred cCCCEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEeeccCCCCCCC--CCCcCCCCee---------------------- Confidence 57899888877777888999999888754 4567765533221100 0000000000 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIG 429 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~ 429 (908) ...+. ..+..+++.+|||++++++|+++.....+.. ... T Consensus 255 ------------~~~~~---------------------------~~~~~~~~~~Ydav~ll~~a~~~~~~~~~~~~~~~~ 295 (824) T 4TLL_D 255 ------------SVSYD---------------------------EWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKS 295 (824) T ss_dssp ------------EEEEC---------------------------SSSSCHHHHHHHHHHHHHHHHHHHHHHSCC---CCC T ss_pred ------------EEEee---------------------------cCCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 00000 0112356789999999999999886542210 011 Q NP_000836.2 430 LCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|... ...++..+.+++++.+|.| | ++.||++|++ ...+.+++++. ++.++.+|.|+.. T Consensus 296 ~~~~~~~~~~~~~~~l~~~l~~~~f~g--G-~~~f~~~g~~~~~~~~i~~~~~---~g~~~~v~~~~~~ 358 (824) T 4TLL_D 296 SCNNIQESRVYEAHMLKRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNQ---ERKWERVGKYKDR 358 (824) T ss_dssp CSSCCTTCCHHHHHHHHHHHHCCEETT--E-ECCBCTTSSBSSCCEEEEEECT---TSCEEEEEEECSS T ss_pred cccccccccceeHHHHHHHHhcCccCC--c-eeeeCCCCccceeeEEEEEecC---CcceEEEEEEECc Confidence 22211 1124567888888889988 7 8999999987 46788888873 3578899998764 No 109 >4TLM_D GluN1/GluN2B; neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: NAG, QEM, JEG; 3.77A {Xenopus laevis} Probab=99.42 E-value=1.3e-17 Score=198.99 Aligned_cols=340 Identities=15% Similarity=0.200 Sum_probs=216.8 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD--LLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~--il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ...+++++||+++|.++ . ++|++++|++++ ++++..+.+...|+.+++..+.+. T Consensus 5 ~~~~~~i~Ig~~~p~sg--------------~--------~~a~~~~n~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~-- 60 (824) T 4TLM_D 5 AQKHPNMDIAVILVGTT--------------E--------EVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIITR-- 60 (824) T ss_dssp ------CEEEEEEECTT--------------C--------CCTHHHHHHTTTTTTSSSCCEEEEEEESSCCHHHHHHH-- T ss_pred cccCCCceEEEEEcCCC--------------h--------HHhhhccccCCCcccCCCCceeEEEeCCCCCHHHHHHH-- Confidence 45567899999999763 1 889999998876 455665667777777665443333 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASS--VSIMVANILRLFKIPQISYASTAPE-LSDNTRYDFFS 193 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~--~~~~va~~~~~~~iP~Is~~~~~~~-l~~~~~~~~~~ 193 (908) +.+++. ++++++++ |+.++. ....++..+...++|++++....+. +++...+++++ T Consensus 61 --~~~l~~------------------~~~v~~vv~G~~~s~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~ 120 (824) T 4TLM_D 61 --ICDLMS------------------DKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFF 120 (824) T ss_dssp --HHHHHH------------------HHCCSEEEEEESCCCSHHHHHHHHHHHHHCCCEEECSHHHHSCCSCCCSSSCEE T ss_pred --HHHHhc------------------cCCCEEEEEcCCCChHHHHHHHHHHHHhhCCCEEEecCCCccccccccccceEE Confidence 333332 15789987 988776 4456677778899999986554432 22233578999 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) ++.+++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.......... ...+....++++++ T Consensus 121 ~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~- 198 (824) T 4TLM_D 121 QFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENS-FVGWELEEVIHLDMSLDDIDSKIQNQLCK- 198 (824) T ss_dssp ESSCCHHHHHHHHHHHHHHTTCCEEEEEEESSTTTTHHHHHHHHHHHHS-SSCCEEEEEEEECSSSCCSSCHHHHHHTT- T ss_pred ecCCCHHHHHHHHHHHHHHcCCeEEEEEEEcCCChHHHHHHHHHHHHhc-cCCcEEEEEEEecCChhhhhHHHHHHHHh- Confidence 9999999999999999988899999999988888888888888877764 34433221111101 11223444555653 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~ 351 (908) .++|+|++......+..+++++++.|+.+ .+.|+..+.|...... .......+.+ T Consensus 199 ~~~~~iv~~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~---------------------- 254 (824) T 4TLM_D 199 LQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDT--VPDEFPTGLI---------------------- 254 (824) T ss_dssp CCCSEEEEESCHHHHHHHHHHHHHHTTTSTTCEEEECHHHHTTSSC--CCTTSCTTCE---------------------- T ss_pred cCCCEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEeeccCCCCCCC--CCCcCCCCee---------------------- Confidence 57899888877777888999999888754 4567765533221100 0000000000 Q NP_000836.2 352 NNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YIG 429 (908) Q Consensus 352 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~~ 429 (908) ...+. ..+..+++.+|||++++++|+++.....+.. ... T Consensus 255 ------------~~~~~---------------------------~~~~~~~~~~Ydav~ll~~a~~~~~~~~~~~~~~~~ 295 (824) T 4TLM_D 255 ------------SVSYD---------------------------EWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKS 295 (824) T ss_dssp ------------EEECC---------------------------TTTCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC T ss_pred ------------EEEee---------------------------cCCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 00000 0112356789999999999999886542210 011 Q NP_000836.2 430 LCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDA-PGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 430 ~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~-~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .|... ...++..+.+++++.+|.| | ++.||++|++ ...+.+++++. ++.++.+|.|+.. T Consensus 296 ~~~~~~~~~~~~~~~l~~~l~~~~f~g--G-~~~f~~~g~~~~~~~~i~~~~~---~g~~~~v~~~~~~ 358 (824) T 4TLM_D 296 SCNNIQESRVYEAHMLKRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNQ---ERKWERVGKYKDR 358 (824) T ss_dssp CSSSCCCTTCTTHHHHHHHHTSCEETT--E-ECCBCTTSBBSCCCEEEEEECS---TTCEEEEEEEETT T ss_pred cccccccccceeHHHHHHHHhcCccCC--c-eeeeCCCCccceeeEEEEEecC---CcceEEEEEEECc Confidence 22211 1124567888888889988 7 8999999987 46788888873 3578899998764 No 110 >4EYQ_A Extracellular ligand-binding receptor; PSI-BIOLOGY, MCSG, MIDWEST CENTER FOR; HET: DHC, MSE, ENO; 1.96A {Rhodopseudomonas palustris} Probab=99.41 E-value=1.8e-17 Score=176.21 Aligned_cols=348 Identities=13% Similarity=0.160 Sum_probs=206.9 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|..+... ..+.....+++.|++++| |+++++.+.|+.+++.. ..+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~~-------g~~i~~~~~d~~~~~~~----~~~~~ 61 (362) T 4EYQ_A 3 AETNEITVGITVTTTGPAA----------ALGIPERNALEFVAKEIG-------GHPIKMIVLDDGGDPTA----ATTNA 61 (362) T ss_dssp CCCSSEEEEEEECCSSTTH----------HHHHHHHHHGGGSCSEET-------TEEEEEEEEECTTCHHH----HHHHH T ss_pred ccCCcEEEEEEEeCCCccH----------HhCccHHHHHHHHHHHhC-------CEEEEEEEEeCCCCHHH----HHHHH Confidence 3456899999999875321 245677888999998875 35567777776655332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++||++.++.....+...+...++|+|.+...... ....++++++.+++. T Consensus 62 ~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~---~~~~~~~~~~~~~~~ 120 (362) T 4EYQ_A 62 RRFVT------------------ESKADVIMGSSVTPPTVAVSNVANEAQVPHIALAPLPVT---PERAKWSVVMPQPIP 120 (362) T ss_dssp HHHHH------------------TSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCCC---HHHHTTEEECSCCHH T ss_pred HHHHH------------------hCCCCEEEecCCChhHHHHHHHHHHhCCCEEEecCCCCC---CcccceeEEcCCCHH Confidence 43332 157889998876665556667788899999987654321 112466778888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. .+..+....+++++. .++|++++ T Consensus 121 ~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~ 196 (362) T 4EYQ_A 121 IMGKVLYEHMKKNNIKTVGYIGYSDSYGDLWFNDLKKQGEAM-GLKIVAEERFA--RPDTSVAGQVLKLVA-ANPDAILV 196 (362) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHCCCCCHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-HCCSEEEE T ss_pred HHHHHHHHHHHhCCCcEEEEEeecChhHHHHHHHHHHHHHHc-CCeEeeeeeeC--CCCCCHHHHHHHHHH-cCCCEEEE Confidence 888899999888899999999866667777888888888765 35544322222 122345566666663 57898877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) +..+..+..+++++++.|+. ..|++.+.+...... ........+.+........... .............|. T Consensus 197 ~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~-----~~~~~~~~~~~~~f~ 268 (362) T 4EYQ_A 197 GASGTAAALPQTALRERGYN--GLIYQTHGAASMDFI-RIAGKSAEGVLMASGPVMDPEG-----QNDSALTKKPGLELN 268 (362) T ss_dssp ECCGGGGHHHHHHHHHTTCC--SEEEECGGGCSHHHH-HHHGGGGTTCEEEECGGGCTTT-----SCTTCTTHHHHHHHH T ss_pred eCChhHhHHHHHHHHHCCCC--ceEEeccccCcHHHH-HHhhhhhcCeEEeecccCCccc-----CCChhhcCCCChHHH Confidence 66666677888888888874 356655433221110 0011122232221110000000 000000000111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+.+.++. ..+..++..+||++++++++++++....... ...+++ T Consensus 269 ~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~--------~~~~~~ 314 (362) T 4EYQ_A 269 TAYETKYGP--------------------------NSRSQFAGHSFDAFKVLERVIPVALKTAKPG--------TQEFRE 314 (362) T ss_dssp HHHHHHHCT--------------------------TCCCHHHHHHHHHHHHHHHHHHHHTTTCCTT--------SHHHHH T ss_pred HHHHHHHCC--------------------------CCCCccccchhHHHHHHHHHHHHHHHhCCCC--------ChHHHH Confidence 222221110 0123567789999999999998875432100 012456 Q NP_000836.2 441 ELLGYIRA-VNFNGSAGTPVTFNENGD---APGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~-~~f~G~~G~~v~Fd~~G~---~~~~~~i~~~~ 477 (908) .+.++|++ ..|.|.+| ++.|+++++ +...+.+++++ T Consensus 315 ~l~~~l~~~~~~~g~~g-~~~f~~~~~~~~~~~~~~i~~~~ 354 (362) T 4EYQ_A 315 AIRKALLTEKDIAASQG-VYSFTETDRYGLDDRSRILLTVK 354 (362) T ss_dssp HHHHHHHHCCCEEETTE-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHhcCCccccce-EEEecCCCCCCCCCCCcEEEEEE Confidence 77888877 68999988 899987654 22355666665 No 111 >3LKB_B Probable branched-chain amino acid ABC; branched amino acid, ABC transporter; HET: VAL; 2.4A {Thermus thermophilus} Probab=99.41 E-value=1.9e-17 Score=178.40 Aligned_cols=360 Identities=13% Similarity=0.146 Sum_probs=216.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+.+++||+++|.++.. ...+.....+++.|++++|+.+++ +|+++++.+.|+.+++.. ..+.++ T Consensus 4 ~~~~~~Ig~~~~~~~~~----------~~~~~~~~~g~~~a~~~~n~~g~~-~g~~~~~~~~d~~~~~~~----~~~~~~ 68 (392) T 3LKB_B 4 GQQQVTLFWSGAITGPT----------SDAGAPYGAAVEDYCKWANERKLV-PGVVFNCVVRDDQYNNAN----TQRFFE 68 (392) T ss_dssp CCEEEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHHTSS-TTEEEEEEEEECTTCHHH----HHHHHH T ss_pred ccCcEEEEEEecCCCCc----------cccchhhHHHHHHHHHHHHHCCCC-CCEEEEEEEEeCCCChHH----HHHHHH Confidence 45689999999986532 125567889999999999987654 477888888887665432 233333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++.+ +++++++++ ++.....+...+...++|+|......+. .....+++++++.+++.. T Consensus 69 ~l~~~------------------~~~~~ii~~-~~~~~~~~~~~~~~~~ip~i~~~~~~~~-~~~~~~~~~~~~~~~~~~ 128 (392) T 3LKB_B 69 EAVDR------------------FKIPVFLSY-ATGANLQLKPLIQELRIPTIPASMHIEL-IDPPNNDYIFLPTTSYSE 128 (392) T ss_dssp HHHHH------------------HCCSCEEEC-CHHHHHHHHHHHHHHTCCEEESCCCGGG-TSSSSCTTBCEEECCHHH T ss_pred HHHHc------------------cCCCEEEec-ccHHHHhHHHHHHHhCCCeeccccChHH-cCCCCCCceeecCCCHHH Confidence 33321 467888854 4544556667778889999987654322 111235678888999888 Q NP_000836.2 202 QAQAMVDIVT-ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 202 ~~~~~~~~l~-~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) .++.+++++. +++|+++++++.++.++..+.+.+.+.+++. ++++.....+. ....+....+++++. .+++++++ T Consensus 129 ~~~~~~~~l~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 204 (392) T 3LKB_B 129 QVVALLEYIAREKKGAKVALVVHPSPFGRAPVEDARKAAREL-GLQIVDVQEVG--SGNLDNTALLKRFEQ-AGVEYVVH 204 (392) T ss_dssp HHHHHHHHHHHHSTTCEEEEEECSSHHHHTTHHHHHHHHHHH-TCEEEEEEECC--TTCCCCHHHHHHHHH-TTCCEEEE T ss_pred HHHHHHHHHHHhcCCCeEEEEECCCHhhcccHHHHHHHHHHc-CCeEEEEEecC--CCCCCHHHHHHHHHH-cCCCEEEE Confidence 8999999984 6799999999976667777888888888775 35554322222 122345556666663 57888877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) ...+..+..+++++++.|+. ..+++.+.+...... ........+.+...... .. ........+. T Consensus 205 ~~~~~~~~~~~~~~~~~g~~--~~i~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~----------~~---~~~~~~~~~~ 268 (392) T 3LKB_B 205 QNVAGPVANILKDAKRLGLK--MRHLGAHYTGGPDLI-ALAGDAAEGFLWATSFY----------MA---HEDTPGIRLQ 268 (392) T ss_dssp ESCHHHHHHHHHHHHHTTCC--CEEEECGGGCSHHHH-HHHGGGGTTCEEEESBC----------CT---TSCCHHHHHH T ss_pred eCCChhHHHHHHHHHHcCCC--CcEEEccccCCHHHH-HHHHHHhCCEEEEeccC----------CC---CCCCHHHHHH Confidence 76566677889999888874 345554432221110 00111122222111100 00 0000111122 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+.+.++... ..........+||++++++.|++++.... ...+++ T Consensus 269 ~~~~~~~~~~~-----------------------~~~~~~~~~~~yda~~~l~~al~~~~~~~-----------~~~~~~ 314 (392) T 3LKB_B 269 KEIGRKYGRPE-----------------------NFIESVNYTNGMLAAAIAVEAIRRAQERF-----------KRITNE 314 (392) T ss_dssp HHHHHHTTCCH-----------------------HHHTCHHHHHHHHHHHHHHHHHHHHHHHH-----------SCCSHH T ss_pred HHHHHHHCCCc-----------------------hhhcchHHHHHHHHHHHHHHHHHHHHHHh-----------CCCCHH Confidence 22222221100 00000112268999999999998875421 012455 Q NP_000836.2 441 ELLGYIRAVN----------FNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 441 ~l~~~l~~~~----------f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+.+.|++.. |.|.+|.++.|+++|++. ..+.+++++ ++.++.|+.|... T Consensus 315 ~l~~~l~~~~~~~~~~~~~~~~g~~G~~i~f~~~~~~~~~~~~i~~~~----~g~~~~v~~~~~~ 375 (392) T 3LKB_B 315 TVYQAIVGMNGPNAFKPGFAVSTKQGVEIDFTKSEHTGAEGLRILEAK----GGRFVPVTEPFTS 375 (392) T ss_dssp HHHHHHHTCSGGGCBCCSSBCCCSSSCSBCCCSSCCEEECCBEEEEEE----TTEEEECSCCBCC T ss_pred HHHHHHHhccCCCCCCCccccccCCcceeeeccCCCCCCccEEEEEEc----CCEEEECCCCcCH Confidence 6667776553 556665369999887765 567787776 3578999999865 No 112 >4F8J_A Putative branched-chain amino acid transport; lignin degratation, Structural Genomics, PSI-Biology; HET: GOL, EPE, SO4, HC4; 1.6A {Rhodopseudomonas palustris} Probab=99.39 E-value=2.8e-17 Score=174.67 Aligned_cols=348 Identities=14% Similarity=0.158 Sum_probs=206.1 Template_Neff=12.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|..+... ..+.....+++.+++++| |+++++.+.|+.+++. ...+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~-------g~~~~~~~~d~~~~~~----~~~~~~ 61 (362) T 4F8J_A 3 AETNEITIGITVTTTGPAA----------ALGIPERNALEFVAKEIG-------GHPLKVIVLDDGGDPT----AATTNA 61 (362) T ss_dssp -CCSSEEEEEEECCSSTTH----------HHHHHHHHGGGGSCSEET-------TEEEEEEEEECTTCHH----HHHHHH T ss_pred ccCCceEEEEEEcCCCchH----------HhCchHHHHHHHHHHHhC-------CEEEEEEEEeCCCCHH----HHHHHH Confidence 3456899999999875321 245677888888888875 4567777777655532 222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++++++|++.++.....+...+...++|+|..+..... ....++++++.+++. T Consensus 62 ~~~~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~---~~~~~~~~~~~~~~~ 120 (362) T 4F8J_A 62 RRFVT------------------ESKADVIMGSSVTPPTVAVSNVANEAQVPHIALAPLPIT---PERAKWSVAMPQPIP 120 (362) T ss_dssp HCCCC------------------CSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCCC---TTTTTTEEECSCCHH T ss_pred HHHHh------------------hcCCCEEEecCCChHHHHHHHHHHHhCCCEEEcCCCCCC---ccccceeeecCCChH Confidence 33332 157899998876665556677788899999987653221 113467788888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .+++++++ T Consensus 121 ~~~~~~~~~l~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 196 (362) T 4F8J_A 121 IMGKVLYEHMKKNNIKTVGYIGYSDSYGDLWFNDLKKQGEAM-GLKIVAEERFA--RPDTSVAGQVLKLVA-ANPDAILV 196 (362) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHCCCCCHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-HCCSEEEE T ss_pred HHHHHHHHHHHhCCCeEEEEEEecCcchHHHHHHHHHHHHHc-CCEEEeeeeeC--CCCCChHHHHHHHHH-cCCCEEEE Confidence 888899999888899999999966667777788888887765 35554322222 122345556666653 57888877 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) +.++..+..+++++++.|+. ..|++.+.+...... ........+.+........... . ... .........|. T Consensus 197 ~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~---~-~~~-~~~~~~~~~f~ 268 (362) T 4F8J_A 197 GASGTAAALPQTSLRERGYK--GLIYQTHGAASMDFI-RIAGKSAEGVLMASGPVMDPEG---Q-DDS-ALTKKPGLELN 268 (362) T ss_dssp ECCHHHHHHHHHHHHHTTCC--SEEEECGGGCBTHHH-HHHGGGGTTCEEEECGGGCGGG---S-CTT-CTTHHHHHHHH T ss_pred eCCHHHchHHHHHHHHCCCC--ceEEeecccCCHHHH-HHccccccCeEEecccccCcCC---C-Cch-hhcCCcchHHH Confidence 76666677888998888874 355555433221110 0011122232221110000000 0 000 00000111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++. ..++.++..+||+++++++|++++....... ...+++ T Consensus 269 ~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~--------~~~~~~ 314 (362) T 4F8J_A 269 TAYEAKYGP--------------------------NSRSQFAAHSFDAFKVLERVVPVALKTAKPG--------TQEFRE 314 (362) T ss_dssp HHHHHHHCT--------------------------TCCBHHHHHHHHHHHHHHHHHHHHHTTCCTT--------SHHHHH T ss_pred HHHHHHHCC--------------------------CCCCccccchhHHHHHHHHHHHHHHHhCCCC--------CHHHHH Confidence 222221110 0123567889999999999998665432100 013456 Q NP_000836.2 441 ELLGYIRA-VNFNGSAGTPVTFNENGDA---PGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~-~~f~G~~G~~v~Fd~~G~~---~~~~~i~~~~ 477 (908) .+.+.|++ ..|.|.+| ++.|+++++. ...+.+++++ T Consensus 315 ~l~~~l~~~~~~~g~~g-~i~f~~~~~~~~~~~~~~i~~~~ 354 (362) T 4F8J_A 315 AIRKALVSEKDIAASQG-VYSFTETDRYGLDDRSRILLTVK 354 (362) T ss_dssp HHHHHHHHSCCEECSSC-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHhccCccccce-eEEecCCCCCCcCcCCcEEEEEE Confidence 78888887 58999988 8999986542 2356677765 No 113 >4U4G_D GluA2*; Ionotropic glutamate receptor, AMPA receptor; HET: NAG, ZK1, BMA; 4.49A {Rattus norvegicus} Probab=99.39 E-value=2.9e-17 Score=195.81 Aligned_cols=356 Identities=15% Similarity=0.188 Sum_probs=224.1 Template_Neff=11.500 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||++.|.++. ....|++.|++++|++ |+++++.+.|+. +++. .+.+.+++ T Consensus 1 ~~i~Ig~~~~~~g~----------------~~~~g~~~a~~~in~~-----g~~l~~~~~d~~~~~~~----~~~~~~~~ 55 (822) T 4U4G_D 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSF----AVTNAFCS 55 (822) T ss_dssp CEEEEEEEEETTCH----------------HHHHHHHHHHHHHCCS-----SCEEEEEEEEECTTCHH----HHHHHHHH T ss_pred CceeEEEecCCCCh----------------HHHHHHHHHHhhccCC-----CceeeeeEEecCCCCHH----HHHHHHHH Confidence 36899999988742 4678999999999975 467888888865 3322 22233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +.. +++++++|+.++..+.++++.+...++|+++++.+++ ..+++++++.++ . T Consensus 56 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~---~ 108 (822) T 4U4G_D 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD---L 108 (822) T ss_dssp HHH-------------------HCCSCEEECCCTTTHHHHHHHHHHHCCCEEESSCCCS-----SCCSSEEECSCC---C T ss_pred HHh-------------------hCeeEEEecCChhHHHHHHHHHhccCCeEEeCCCCCC-----CCCCeEEEecCC---H Confidence 332 5789999998887777888888899999998876543 246889999887 4 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ++.+++++++++|+++++++ +++++....+.+++.+++. ++++.....++. +.+..++...++++++ .++|+|++ T Consensus 109 ~~~~~~~l~~~~~~~v~iv~-~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~i~~ 185 (822) T 4U4G_D 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (822) T ss_dssp HHHHHHHHHHTTCCEEEEEE-CGGGCTHHHHHHHHHHHHH-TCEEEEEECSSCCSSSCSTTTTTHHHHTTS-SCCCEEEE T ss_pred HHHHHHHHHHcCCCEEEEEE-cCcchHHHHHHHHHHHHhc-CCeEEEEEccCCCCCCCcchhHHHHHHHHh-cCCcEEEE Confidence 67788888888999999999 5667777777787777764 455544332210 0122456667777763 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) .+....+..+++++++.|+.. .+.|++.+.+...... ........+....... ....+....| T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~~~~f 249 (822) T 4U4G_D 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQIV---------------DYDDSLVSKF 249 (822) T ss_dssp ESCHHHHHHHHHHHHHHTCSSTTCEEEECSSBTTTSCC-TTTTTSSCEEEEEESS---------------CTTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCCCCCeEEEEeeCCCCCCch-HhcccCCeeEEEEEEe---------------eCCchHHHHH Confidence 877767788899998888753 3566665422211100 0000001111111000 0011122233 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.++.... + . ....++.++..+|||++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~~~-----------~--~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (822) T 4U4G_D 250 IERWSTLEEKEYP-----------G--A------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (822) T ss_dssp HHHHTTSCTTTST-----------T--C------CSSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCSSCCCCTTCSS T ss_pred HHHHHhcchhcCC-----------C--C------CCCCCchhHHHHHHHHHHHHHHHHHHHHhccccccCCCCCCCccCC Confidence 3434333321000 0 0 00123456788999999999999998653210 001122211 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.++|++..|.|.+| ++.|+++|++.. .+.+++++ ++.++.+|.|... T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~v~~~~~~ 368 (822) T 4U4G_D 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (822) T ss_dssp CCCCTTHHHHHHHHHHCCEEETTE-EECBCTTCCBCSCCEEEEEEE----TTEEEEEEEEETT T ss_pred CCCccchHHHHHHHHhccccCCCc-cEEECCCCcEEEeEEEEEEec----CCCceeeEEeeCC Confidence 1124567888888889999988 899999888764 78888887 3568888888753 No 114 >6PEQ_D Glutamate receptor 2, Protein cornichon; ionotropic glutamate receptor, AMPA receptor; HET: CLR, OLC, PAM, ZK1; 2.97A {Rattus norvegicus} Probab=99.39 E-value=3.4e-17 Score=196.89 Aligned_cols=360 Identities=15% Similarity=0.192 Sum_probs=225.1 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~ 118 (908) ...+++++||++.|.++. ....|++.|++++|++ |.++++.+.| +++++.. +.+ T Consensus 21 ~~~~~~i~Ig~~~~~~g~----------------~~~~g~~~a~~~in~~-----g~~l~~~~~d~~~~~~~~----~~~ 75 (889) T 6PEQ_D 21 GVSSNSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTN 75 (889) T ss_pred hccCCeEEEeEeeCCCCh----------------HHHHHHHHHHHhcccc-----CceeccceeecCccCHHH----HHH Confidence 456689999999998652 4678999999999975 4678888888 4444322 223 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) .+++++. +++++++|+.++..+.+++..+...++|++++...++ ..+++++++.++ T Consensus 76 ~~~~l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~ 131 (889) T 6PEQ_D 76 AFCSQFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPD 131 (889) T ss_pred HHHHHHh-------------------cCeeEEEEcCChHHHHHHHHHHhccCCcEEEcCCCCC-----CCCCcEEEeecC Confidence 3333332 5789999998887777888888999999998876443 247889999887 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNAR 276 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ 276 (908) .++++++++++++|+++++++ +++++....+.+++.+++. ++++......+. ..+..++...++++++ .++| T Consensus 132 ---~~~~~~~~~~~~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~i~~-~~~~ 205 (889) T 6PEQ_D 132 ---LKGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKER 205 (889) T ss_pred ---hHHHHHHHHHHhCCCEEEEEE-eCcchhHHHHHHHHHHHhh-CCeEEEEEccCCCCCCCchhhHHHHHHhcc-CCCe Confidence 577888888888999999999 5567777777787777765 355543322210 0112355667777763 5789 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRR 355 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 355 (908) +|++...+..+..+++++++.|+.. .+.|++.+.+...... ........+....... ....+. T Consensus 206 ~vi~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~ 269 (889) T 6PEQ_D 206 RVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGANVSGFQIV---------------DYDDSL 269 (889) T ss_pred EEEEECCHHHHHHHHHHHHHhCCCCCCeEEEEEeCCCCcccH-HHhccCCcceEEEEEe---------------eCCcHH Confidence 9988877777888999998888753 4567765532221100 0000001111110000 000111 Q NP_000836.2 356 NVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLC 431 (908) Q Consensus 356 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~ 431 (908) ...|.+.+.+.++.. +... ....++.++..+|||+++++.|++++...... .....| T Consensus 270 ~~~f~~~~~~~~~~~-------------~~~~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~ 330 (889) T 6PEQ_D 270 VSKFIERWSTLEEKE-------------YPGA------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDC 330 (889) T ss_pred HHHHHHHHHhccccc-------------CCCC------CCCCCChHHHHHHHHHHHHHHHHHHHHHhhhccccCCCCCCC Confidence 222333333332210 0000 00123456788999999999999988643210 000122 Q NP_000836.2 432 PRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 432 ~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ... ...++..+.+.|++..|.|.+| ++.||++|++.. .+.+.+++ ++.++.++.|... T Consensus 331 ~~~~~~~~~~~~~i~~~l~~~~~~g~~G-~v~f~~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~ 392 (889) T 6PEQ_D 331 LANPAVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 392 (889) T ss_pred CCCCCCCccchHHHHHHHHhcCccCCCc-cEEECCCCcEeeeEEEEEEec----cCCceEEEEEeCC Confidence 110 1124566778888889999988 899999888754 78888887 2457777878754 No 115 >3UK0_A Extracellular ligand-binding receptor; STRUCTURAL GENOMICS, PSI-BIOLOGY, MIDWEST CENTER; HET: ENO, MSE, SO4; 1.49A {Rhodopseudomonas palustris} Probab=99.38 E-value=3.5e-17 Score=173.93 Aligned_cols=348 Identities=14% Similarity=0.163 Sum_probs=203.7 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++... ..+.....+++.+++++| |.++++.+.|+.+++.. ..+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~~~~~a~~~~~-------g~~~~~~~~~~~~~~~~----~~~~~ 61 (362) T 3UK0_A 3 AETNEITVGISVTTTGPAA----------ALGIPERNALEFVVKEIS-------GHPIKIIVLDDGGDPTA----ATTNA 61 (362) T ss_dssp -CCCCEEEEEEECCSSTTH----------HHHHHHHHGGGGSCSEET-------TEEEEEEEEECTTCHHH----HHHHH T ss_pred ccCCcEEEEEEEecCCCcH----------HhCCCHHHHHHHHHHHhc-------CeEEEEEEEeCCCCHHH----HHHHH Confidence 3456899999999865321 245677889999999987 34566667776555332 22333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++||++.++.....+...+...++|+|........ ....++++++.+++. T Consensus 62 ~~l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~---~~~~~~~~~~~~~~~ 120 (362) T 3UK0_A 62 RRFVT------------------ESKADVIMGSSVTPPSVAISNVANEAQIPHIALAPLPIT---PERAKWSVVMPQPIP 120 (362) T ss_dssp HHHHH------------------TSCCSEEEECSSHHHHHHHHHHHHHHTCCEEESSCCCCC---TTTTTTEEECSCCHH T ss_pred HHHHH------------------hcCCCEEEecCCChHHHHHHHHHHHcCCCEEEccCCCCC---CcccCceeecCCCHH Confidence 33332 157889998776655556667778889999987654221 112466788888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .+++++++ T Consensus 121 ~~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 196 (362) T 3UK0_A 121 IMGKVLYEHMKKNNVKTVGYIGYSDSYGDLWFNDLKKQGEAM-GLKIVGEERFA--RPDTSVAGQALKLVA-ANPDAILV 196 (362) T ss_dssp HHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHCCCCCHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHH-HCCSEEEE T ss_pred HHHHHHHHHHHHCCCCEEEEEEecCcchHHHHHHHHHHHHHc-CCEEeeEEEeC--CCCCChHHHHHHHHH-cCCCEEEE Confidence 888889998887899999999966667777888888888765 35544322222 112334455666653 47888867 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 360 (908) +..+..+..+++++++.|+. ..+++.+.+...... ........+.+........... .............|. T Consensus 197 ~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~g~~~~~~~~~~~~~-----~~~~~~~~~~~~~f~ 268 (362) T 3UK0_A 197 GASGTAAALPQTTLRERGYN--GLIYQTHGAASMDFI-RIAGKSAEGVLMASGPVMDPEG-----QDDTALTKKPGMALV 268 (362) T ss_dssp ECCHHHHHHHHHHHHHTTCC--SEEEECGGGCSHHHH-HHHGGGGTTCEEEECGGGCSTT-----SCTTCTTHHHHHHHH T ss_pred eCCHHHchhHHHHHHHcCCc--ceEEEcCcccCHHHH-HHhhhhhcCcEEeecCCCCCCC-----CCchhccCcchHHHH Confidence 66666677888998888874 355555433221110 0011122333221110000000 000000000111222 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.|++.++. ..++.++..+||+++++++++++++...... ....++ T Consensus 269 ~~~~~~~~~--------------------------~~~~~~~~~~yda~~~~~~a~~~a~~~~~~~--------~~~~~~ 314 (362) T 3UK0_A 269 KVYEEKYGP--------------------------SSRSQFAGHSYDAFKVLERVVPVALKKAKPG--------TQEFRE 314 (362) T ss_dssp HHHHHHHCT--------------------------TCCCHHHHHHHHHHHHHHHHHHHHHTTCCTT--------SHHHHH T ss_pred HHHHHHHCC--------------------------CCCCcccccchhHHHHHHHHHHHHHHhcCCC--------CHHHHH Confidence 222221110 0123567789999999999877665432100 112455 Q NP_000836.2 441 ELLGYIRA-VNFNGSAGTPVTFNENGD---APGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~-~~f~G~~G~~v~Fd~~G~---~~~~~~i~~~~ 477 (908) .+.++|++ ..|+|.+| ++.|+++++ +...+.+++++ T Consensus 315 ~l~~~l~~~~~~~g~~g-~i~f~~~~~~~~~~~~~~i~~~~ 354 (362) T 3UK0_A 315 ALREAFLTEKDIAASQG-VYNFTETDRYGLDDRSRILLTVK 354 (362) T ss_dssp HHHHHHHHCCCEECSSC-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHcCCccccccc-eEEeCCCCccccCccceEEEEEE Confidence 67777775 57899888 899987643 22355666665 No 116 >4TLL_C GluN1/GluN2B; Neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: JEG, QEM, NAG; 3.59A {Xenopus laevis} Probab=99.38 E-value=3.6e-17 Score=194.78 Aligned_cols=349 Identities=18% Similarity=0.271 Sum_probs=228.5 Template_Neff=11.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++ ...|++.|++++|+.+ .|.++++...|+.+++.. .+...+.+++ T Consensus 3 ~~~i~IG~i~~~~~------------------~~~~~~~a~~~~n~~g---~g~~i~l~~~d~~~~~~~-~~~~~~~~~~ 60 (823) T 4TLL_C 3 PKIVNIGAVLSTKK------------------HEQIFREAVNQANFFH---FTRKIQLNATSVTHRPNA-IQMALSVCED 60 (823) T ss_dssp CEEEEEEEEESSHH------------------HHHHHHHHHHHHHHSS---CTTTEEEEECCEECCSSH-HHHHHHCCCC T ss_pred CceeeeeEEecCch------------------HHHHHHHHHHHHhhcc---CCCceeccccccCCCCCH-HHHHHHHHHH Confidence 47899999998752 4578999999999865 267788888887655332 0113333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-----IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-----~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.. +++++++|+.++..+ ..++..+...++|+|++.+..+.+.++..+++++++.+ T Consensus 61 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 121 (823) T 4TLL_C 61 LIS-------------------SQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 121 (823) T ss_dssp CGG-------------------GCCSCEEECCCSSCCTTCTTHHHHHHHHHTTCCEEESSCCCGGGSCTTTCSSEEESSC T ss_pred HHh-------------------cCceEEEEcCCCCCCCcCCchHHHHhhccccCCEEEeecCCcccCCCCcccceeecCC Confidence 332 478999998887776 55666888899999998876665554335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.....+. .+..+....++++++ .++|+ T Consensus 122 ~~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ 197 (823) T 4TLL_C 122 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEK-ESKADKVLQFE--PGTKNLTALLLEAKE-LEARV 197 (823) T ss_dssp CSGGGHHHHHHHHHHHTCCCCEEEEESSHHHHHHHHHHHHHHTSS-TTCCCEEEEEC--TTCSCCHHHHHHHHH-SSCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEecCcchHHHHHHHHHHHHhc-cccccEEeccC--CCCccHHHHHHHHHh-CCceE Confidence 999999999999988899999999987788888888888888775 45554333232 122345666777763 57899 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+.+..+..+++++++.|+.. .+.|++.+.+.... .......+.+. T Consensus 198 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~----~~~~~~~~~~~-------------------------- 247 (823) T 4TLL_C 198 IILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGS----ALRYAPDGIIG-------------------------- 247 (823) T ss_dssp EEEECCHHHHHHHHHHHHHTTTTSTTCEEEECTTTSSTH----HHHSCCTTCEE-------------------------- T ss_pred EEEECCHHHHHHHHHHHHhcCccCCCeEEEEecCCCCch----hhhcCCCceEE-------------------------- Confidence 888877777888999998888753 34455543221110 00000000000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IGLCPRM- 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~~~~~~- 434 (908) ... ..+..++..+|||++.++.|+++......... ...|... T Consensus 248 ---~~~---------------------------------~~~~~~~~~~ydav~~~~~a~~~~~~~~~~~~~~~~~~~~~ 291 (823) T 4TLL_C 248 ---LQL---------------------------------INGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNT 291 (823) T ss_dssp ---EEE---------------------------------TTSSCSHHHHHHHHHHHHHHHHHHTTSSSCCCCCSCSTTCC T ss_pred ---EEE---------------------------------cCCCCccchHHHHHHHHHHHHHHHHhcCCCCCCCCCcCCCC Confidence 000 00122456789999999999988764321110 0111110 Q NP_000836.2 435 -STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLH-LKVEDMQWAHR 507 (908) Q Consensus 435 -~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~-~~~~~i~w~~~ 507 (908) ...+++.+.+.|++. .|.|.+| .+.||++|++. ..+.+.+++ ++.++.++.|+.... .....+.|+.+ T Consensus 292 ~~~~~~~~l~~~l~~~~~~~G~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (823) T 4TLL_C 292 NIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFDGSYIIQNDRKIIWPGG 363 (823) T ss_dssp SCCTTHHHHHHHHHTCCCTTCTTS-CCEECTTSCEESCCEEEEEEC----SSSEEEEEEECSSSCEECSSCCCCTTS T ss_pred CccccHHHHHHHHHcCCCCCCccc-cEEECCCCCEEeeEEEEEEcc----CCceEEEEEeeCCceeecCCceeCCCC Confidence 012345677777754 6889888 89999988874 677788876 357899999986532 12224667653 No 117 >4TLM_C GluN1/GluN2B; neurotransmitter receptor, NMDA receptor, GluN1/GluN2B; HET: NAG, QEM, JEG; 3.77A {Xenopus laevis} Probab=99.38 E-value=3.6e-17 Score=194.78 Aligned_cols=349 Identities=18% Similarity=0.271 Sum_probs=228.5 Template_Neff=11.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++ ...|++.|++++|+.+ .|.++++...|+.+++.. .+...+.+++ T Consensus 3 ~~~i~IG~i~~~~~------------------~~~~~~~a~~~~n~~g---~g~~i~l~~~d~~~~~~~-~~~~~~~~~~ 60 (823) T 4TLM_C 3 PKIVNIGAVLSTKK------------------HEQIFREAVNQANFFH---FTRKIQLNATSVTHRPNA-IQMALSVCED 60 (823) T ss_dssp CCEEEEEEEESCHH------------------HHHHHHHHHHHHHHTS---CTTTCEEEEEEEECCSSH-HHHHHHCCCC T ss_pred CceeeeeEEecCch------------------HHHHHHHHHHHHhhcc---CCCceeccccccCCCCCH-HHHHHHHHHH Confidence 47899999998752 4578999999999865 267788888887655332 0113333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-----IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-----~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.. +++++++|+.++..+ ..++..+...++|+|++.+..+.+.++..+++++++.+ T Consensus 61 l~~-------------------~~v~~vig~~~s~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~ 121 (823) T 4TLM_C 61 LIS-------------------SQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 121 (823) T ss_dssp CGG-------------------GTCSCEEECCCSSCCSSCTTSHHHHHHHHHTCCEEESSCCCGGGSCTTTCSSEEESSC T ss_pred HHh-------------------cCceEEEEcCCCCCCCcCCchHHHHhhccccCCEEEeecCCcccCCCCcccceeecCC Confidence 332 478999998887776 55666888899999998876665554335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++..+++++++++++++|+++++++.+++++....+.+++.+++. ++++.....+. .+..+....++++++ .++|+ T Consensus 122 ~~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ 197 (823) T 4TLM_C 122 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEK-ESKADKVLQFE--PGTKNLTALLLEAKE-LEARV 197 (823) T ss_dssp CTTTHHHHHHHHHHHHTCCCCEEEEESSHHHHHHHHHHHHHHHHS-SCCCSCEEEEC--TTCSCCHHHHHHHHH-SSCCE T ss_pred CHHHHHHHHHHHHHHcCCCEEEEEEecCcchHHHHHHHHHHHHhc-cccccEEeccC--CCCccHHHHHHHHHh-CCceE Confidence 999999999999988899999999987788888888888888775 45554333232 122345666777763 57899 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+.+..+..+++++++.|+.. .+.|++.+.+.... .......+.+. T Consensus 198 vv~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~----~~~~~~~~~~~-------------------------- 247 (823) T 4TLM_C 198 IILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGS----ALRYAPDGIIG-------------------------- 247 (823) T ss_dssp EEEECCHHHHHHHHHHHHHTTTTSTTCEEEECHHHHSTH----HHHHCCTTCEE-------------------------- T ss_pred EEEECCHHHHHHHHHHHHhcCccCCCeEEEEecCCCCch----hhhcCCCceEE-------------------------- Confidence 888877777888999998888753 34455543221110 00000000000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IGLCPRM- 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~~~~~~- 434 (908) ... ..+..++..+|||++.++.|+++......... ...|... T Consensus 248 ---~~~---------------------------------~~~~~~~~~~ydav~~~~~a~~~~~~~~~~~~~~~~~~~~~ 291 (823) T 4TLM_C 248 ---LQL---------------------------------INGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNT 291 (823) T ss_dssp ---EEE---------------------------------TTSSCHHHHHHHHHHHHHHHHHHHTTSSCCCCCCSSSTTCC T ss_pred ---EEE---------------------------------cCCCCccchHHHHHHHHHHHHHHHHhcCCCCCCCCCcCCCC Confidence 000 00122456789999999999988764321110 0111110 Q NP_000836.2 435 -STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQLH-LKVEDMQWAHR 507 (908) Q Consensus 435 -~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~~~-~~~~~i~w~~~ 507 (908) ...+++.+.+.|++. .|.|.+| .+.||++|++. ..+.+.+++ ++.++.++.|+.... .....+.|+.+ T Consensus 292 ~~~~~~~~l~~~l~~~~~~~G~~G-~i~fd~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~~~~~~~~~~~~~~~ 363 (823) T 4TLM_C 292 NIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFDGSYIIQNDRKIIWPGG 363 (823) T ss_dssp SCCTHHHHHHHHHHTCCCCCCSSC-CCCBCTTSCBCSCCEEEEECG----GGSCEEEEEEETTEEEECSSCCCCSSS T ss_pred CccccHHHHHHHHHcCCCCCCccc-cEEECCCCCEEeeEEEEEEcc----CCceEEEEEeeCCceeecCCceeCCCC Confidence 012345677777754 6889888 89999988874 677788876 357899999986532 12224667653 No 118 >4MPT_B Putative leu/ile/val-binding protein; Structural Genomics, PSI-Biology, Midwest Center; HET: ACY, MSE; 1.75A {Bordetella pertussis Tohama I} Probab=99.38 E-value=3.6e-17 Score=175.27 Aligned_cols=354 Identities=16% Similarity=0.200 Sum_probs=209.4 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR-ILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~-~~d~~~~~~~a~~~~~~~~ 120 (908) .+++++||+++|.++... ..+.....|++.|++++|+.+++. |+++++. +.|+.+++.. ..+.+ T Consensus 3 ~~~~~~Ig~~~~~~~~~~----------~~~~~~~~~~~~a~~~~n~~~g~~-g~~v~l~~~~d~~~~~~~----~~~~~ 67 (380) T 4MPT_B 3 AADTIKIGMTSALTGPYN----------EFGEGNRRAVELAVEQWNAKGGIN-GKKIEIAMLLDDQLNPDR----AVQNI 67 (380) T ss_dssp --CEEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHHTTTSBT-TBEEEEEEEEECTTCHHH----HHHHH T ss_pred cCCceEEEEEecCCCCch----------HHhHHHHHHHHHHHHHHHHCCCCC-CeEEEEEEEEcCCCCHHH----HHHHH Confidence 457899999999875421 245678899999999999876543 6778877 6776655432 33344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSD------NTRYDFFSR 194 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~------~~~~~~~~~ 194 (908) ++++.+ ++++++||+.++.....+...+...++|+|......+.+.. ...++++++ T Consensus 68 ~~l~~~------------------~~~~~vig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 129 (380) T 4MPT_B 68 RAILDN------------------KDIVGIIGPAGSGPMLAVIDMVQADGRPYMNPIAQTPVVTYPGEKTGEKPRPNVFS 129 (380) T ss_dssp HHHHTC------------------TTCCCEECCSSHHHHHHHHHHHHHHCSCEEECSCCCGGGTCTTSSTTSSCCTTEEE T ss_pred HHHHhc------------------CCEEEEECCCCCHHHHHHHHHHHHhCCcEEcccCCCCcccCCCCcCCCCCCCceEE Confidence 444321 47889999887766667778888899999988766554321 113577899 Q NP_000836.2 195 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 195 ~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) +.+++...+..+++++.+ +|++|++++.++.++..+.+.+++.+++..++++.....+. .+..++...+++++. .+ T Consensus 130 ~~~~~~~~~~~~~~~l~~-~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~~~~~~~~~-~~ 205 (380) T 4MPT_B 130 FALQNDIEAVAMGEYLAK-KFKRVGIIHESTAYGVTGVDYLAASIAKNGGAKPVATDSYN--QGAQDMTAQVARMKR-AN 205 (380) T ss_dssp CSCCHHHHHHHHHHHHHH-HCSSEEEEEESSHHHHHHHHHHHHHHHHTTCCCCSEEEEEC--TTCSCCHHHHHHHHT-TT T ss_pred EecCchHHHHHHHHHHHh-hCCeEEEEecCChhhhhHHHHHHHHHHHcCCCeeeEEEeec--CCCCchHHHHHHHHH-CC Confidence 999988888888888876 89999999966667777888888777653224443322222 122345566666663 57 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNR 354 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~ 354 (908) ++++++...+..+..+++++++.|+. ..+++.+.+...... ........+.+...... +.. ...+ T Consensus 206 ~~~i~~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~---------~~~---~~~~ 270 (380) T 4MPT_B 206 VDAIAAIGLGKDLAVLRRTMARLNVN--VPLAASNGALGQPYQ-EGAGELTLGTLGTMIGA---------FGN---PMRA 270 (380) T ss_dssp CSEEEEESCHHHHHHHHHHHHHTTCC--CCEEECGGGGSHHHH-HHHGGGGTTCEEEEECT---------TSS---SCCH T ss_pred CCEEEEEcCchHHHHHHHHHHHcCCC--CCEEEcchhcCHHHH-HHhhHhhCCeeEEeecc---------cCC---CCCh Confidence 88887776666677888888887764 345554432211100 00011112221111000 000 0001 Q NP_000836.2 355 RNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRM 434 (908) Q Consensus 355 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~ 434 (908) ....|.+.+.+.++...... . .. .........++..+|||+++++++++++.. T Consensus 271 ~~~~f~~~~~~~~~~~~~~~---~----~~-------~~~~~~~~~~~~~~yda~~~~~~a~~~~~~------------- 323 (380) T 4MPT_B 271 PAADFAKAYKAKYGTDRWWG---N----DP-------ENPQLFMAISVSNGYDAANILFEGIRLANS------------- 323 (380) T ss_dssp HHHHHHHHHHHHHCSCTTTC---S----CT-------TSCCTTHCCCCCHHHHHHHHHHHHHHHHTS------------- T ss_pred HHHHHHHHHHHHHCCCccCC---C----CC-------CCchhhhhHHHHHHHHHHHHHHHHHHHcCC------------- Confidence 11223333332221100000 0 00 000000012367899999999999987642 Q NP_000836.2 435 STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDA---PGRYDIFQYQ 477 (908) Q Consensus 435 ~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~---~~~~~i~~~~ 477 (908) .++..+.++|++. .|.|.+| ++.|+++|++ ...+.++++. T Consensus 324 --~~~~~i~~~l~~~~~~~g~~g-~~~f~~~~~~~~~~~~~~v~~~~ 367 (380) T 4MPT_B 324 --TDPKAVIAAIESIKDYQGVNT-AYTFSKERHHGIETDGVKVFEYV 367 (380) T ss_dssp --CCHHHHHHHHTTCCSEECSSC-EECCCSSCCBCCCGGGEEEEEEE T ss_pred --CCHHHHHHHHHcCCCcccccc-eEEeecCcccccccceeEEEEEE Confidence 1345677788765 7899888 8999986543 2356666665 No 119 >4ZPJ_A Extracellular ligand-binding receptor; ABC transporter, substrate-binding protein, DUF3597; HET: ZN, MSE; 2.24A {Sphaerobacter thermophilus (strain DSM 20745 / S 6022)} Probab=99.37 E-value=5.1e-17 Score=177.05 Aligned_cols=346 Identities=19% Similarity=0.206 Sum_probs=206.4 Template_Neff=11.500 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||++.|.++... ..+.....+++.|++++|+. ..|+++++.+.|+.+++.. ..+ T Consensus 48 ~~~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~---~~g~~~~l~~~d~~~~~~~----~~~ 110 (423) T 4ZPJ_A 48 SSASGEPIRIGVLLTLSGPQG----------VNGEGNLRGLTLALDQAGMQ---FGGRPVELIIEDSAGQPEQ----AIT 110 (423) T ss_dssp -----CCEEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHTTTE---ETTEEEEEEEEECTTCHHH----HHH T ss_pred cccCCCCEEEEEEECCCCCch----------hHhHHHHHHHHHHHHHhccc---cCCEEEEEEEEcCCCCHHH----HHH Confidence 345677899999999875421 24567889999999999864 2367788888776655332 233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN--TRYDFFSRVV 196 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~--~~~~~~~~~~ 196 (908) .+++++.+ +++++++++.++.....+...+...+||+|.+....+.+... ..+++++++. T Consensus 111 ~~~~l~~~------------------~~~~~iig~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~ 172 (423) T 4ZPJ_A 111 KTRQLIER------------------DRVHLIAGITLSNEAAAVRDILVQAEMPTIVTNAGLQALTRDPAMRSPYLFRVS 172 (423) T ss_dssp HHHHHHHT------------------SCCSEEEECCCHHHHHHHHHHHHHTTCCEEESSCCCTHHHHSTTTCCTTEEESS T ss_pred HHHHHHHh------------------cCCcEEEecCCcHHHHHHHHHHHHCCCCEEEccCCcHHHcCCcccCCCceEEee Confidence 33433321 468888888766555566777888999999987655433211 1256788888 Q NP_000836.2 197 PPDSYQAQAMVDIVT-ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PN 274 (908) Q Consensus 197 ~~~~~~~~~~~~~l~-~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~ 274 (908) ++....++.+++++. +++|+++++++.++.++..+.+.|++.+++. ++++.....+. ....+....+++++.. .+ T Consensus 173 ~~~~~~~~~~~~~l~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~~~~~~~~~~~~~~~~~~~ 249 (423) T 4ZPJ_A 173 FANGQYDAPAADYAYETLGYRRMVLHAADYAAGHEEMAAFRSRFEQA-GGEIVDEVVAP--IGTQDFGPYLQRIEQAAAE 249 (423) T ss_dssp CCTTTTTHHHHHHHHHTTCCCEEEEEEESSHHHHHHHHHHHHHHHHT-TCEEEEEEEEC--TTCSCCHHHHHHHHHHGGG T ss_pred cCcccchHHHHHHHHHHhCCCEEEEEEeCcHHHHHHHHHHHHHHHHc-CCEEceEEecC--CCCCChHHHHHHHHHHHcC Confidence 888888888888884 4589999999866667777788888888775 35544322222 1123344556666521 26 Q NP_000836.2 275 ARAVIMFA-NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANN 353 (908) Q Consensus 275 ~~viv~~~-~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~ 353 (908) +++|++.. .+..+..+++++++.|+..++.+++.+.+...... ........+.+...... . .... T Consensus 250 ~~~ii~~~~~~~~~~~~~~~~~~~g~~~~~~ii~~~~~~~~~~~-~~~~~~~~~~~~~~~~~----------~---~~~~ 315 (423) T 4ZPJ_A 250 ADAVFAFHGTSTDAIRFLVQYQEFGLKDSIPLIPSGADVDQSIL-PEIGDAALGLVSGTLYT----------A---YNDT 315 (423) T ss_dssp CSEEEEECCSSHHHHHHHHHHHHTTCTTTSCEEECGGGGCTTTH-HHHGGGGTTCEEEESCC----------T---TCCS T ss_pred CCEEEEEcCChHHHHHHHHHHHHcCCCCCCcEecCCcccChhHH-HHHHHhhcceeEeeccc----------c---CCCC Confidence 78887664 35567788888888887533455555433221100 00111122222111100 0 0001 Q NP_000836.2 354 RRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPR 433 (908) Q Consensus 354 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~ 433 (908) +....|.+.|++.+.. ..+..++..+||+++++++|+++.... T Consensus 316 ~~~~~f~~~~~~~~~~--------------------------~~~~~~~~~~yda~~~l~~al~~~~~~----------- 358 (423) T 4ZPJ_A 316 PESQEFVEAFTARHEG--------------------------ILPGLVDYAGYIGGRVIAEALTAIDGE----------- 358 (423) T ss_dssp HHHHHHHHHHHHHTTT--------------------------CCCCHHHHHHHHHHHHHHHHHHHTTTC----------- T ss_pred HHHHHHHHHHHHHhCC--------------------------CCCChhhHHHHHHHHHHHHHHHHcCCC----------- Confidence 1112232222222110 012345678999999999999886431 Q NP_000836.2 434 MSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQY 476 (908) Q Consensus 434 ~~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~ 476 (908) ..+++.+.+.|++..|.|.+| ++.|+++|++. ..+.++++ T Consensus 359 --~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~~~~~ 399 (423) T 4ZPJ_A 359 --VENKEALLEALKAVEFTGPAG-NFRFHPESQGPVTTILLCRV 399 (423) T ss_dssp --TTCHHHHHHHHHHCEEEETTE-EEEECTTTCSEEEEEEEEEE T ss_pred --CCCHHHHHHHHHcCCcccCCe-eEEECCCCCCceeeEEEEEE Confidence 124556778888888999988 89999887653 33444433 No 120 >6DLZ_B Glutamate receptor 2,Voltage-dependent calcium channel; Ion channel, TRANSPORT PROTEIN; HET: GLU, CYZ; 3.9A {Rattus norvegicus} Probab=99.37 E-value=5.2e-17 Score=198.52 Aligned_cols=356 Identities=15% Similarity=0.186 Sum_probs=226.0 Template_Neff=11.100 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|++.|++++|++ |+++++...|+. +++.. +.+.+++ T Consensus 1 ~~i~IG~~~~~~~~----------------~~~~g~~~A~~~iN~~-----g~~i~l~~~d~~~~~~~~----a~~~~~~ 55 (1031) T 6DLZ_B 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCS 55 (1031) T ss_dssp CCEEEEEEECTTCH----------------HHHHHHHHHHHHSCCS-----SCCEEEEEEECCSSCHHH----HHHHHHH T ss_pred CceeeeeeeCCCCh----------------HHHHHHHHHHHHhhcC-----CceeccceEecCCCCHHH----HHHHHHH Confidence 36899999998642 4678999999999985 477888888876 44322 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. +++++++|+.++....+++..+...++|++++..++. ..+++++++.|+. T Consensus 56 l~~-------------------~~v~aviG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~~--- 108 (1031) T 6DLZ_B 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPDL--- 108 (1031) T ss_dssp HHH-------------------HTCSCEEECCCTTTHHHHHHHHHHHCCCEEECSSCCS-----SCCTTEEECSCCC--- T ss_pred HHh-------------------cCeeEEEecCChHHHHHHHHHHhccCCcEEEcCCCCC-----CCCCeEEEeeccH--- Confidence 332 5799999998887777888889999999998875433 2478899998873 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +.++++++++++|+++++++ +++++....+.+.+.+++. ++++.....+.. +.+..++.+.++++++ .++|+|++ T Consensus 109 ~~~~~~~l~~~~~~~v~ii~-~~~~g~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~d~~~~~~~i~~-~~~~~vv~ 185 (1031) T 6DLZ_B 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (1031) T ss_dssp HHHHHHHHHHHTCSEEEEEE-CGGGCSHHHHHHHHHHHHT-TCEEEEEECTTCCSTTTTTHHHHHHHHHTT-TTCCEEEE T ss_pred HHHHHHHHHHhCCCEEEEEE-eCcchHHHHHHHHHHHhhc-CCeEEEEEecCCCCCCCcchhHHHHHHHcc-cCceEEEE Confidence 67778888888999999999 6678887788888877765 455543332210 0123456677777764 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|+..+........ ........+....... ....+....+ T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~~~~f 249 (1031) T 6DLZ_B 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQIV---------------DYDDSLVSKF 249 (1031) T ss_dssp ECCHHHHHHHHHHHHHHTCCSTTCEEEECSSBTTTSCC-SSSSSSSCEEEEEESC---------------CTTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHhCCccCCcEEEEEeCCCCcCcH-HHhccCCceEEEEEEe---------------eCCcHHHHHH Confidence 877777888999999988854 3566665422211100 0000111111111000 0001112223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.++..... . ....++.++..+||+++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~~~~-------------~------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (1031) T 6DLZ_B 250 IERWSTLEEKEYPG-------------A------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (1031) T ss_dssp HHHHHTSCTTTSTT-------------C------SSSCCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCCSCCCCTTCTT T ss_pred HHHHHhcccccCCC-------------C------CcCCCcHHHHHHHHHHHHHHHHHHHHHHcccccccCCCCCCCccCC Confidence 33333322210000 0 00123456788999999999999998653210 000112110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.++|++..|.|..| ++.|+++|++.. .+.+++++ ++.+..+|.|+.. T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~g~~~~~~~~i~~~~----~~~~~~~~~~~~~ 368 (1031) T 6DLZ_B 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (1031) T ss_dssp CCCCTHHHHHHHHHTTCCCEETTE-ECEECSSSCEESCEEEEEEEC----SSCEEEEEEEESS T ss_pred CCCcccHHHHHHHHHhcCccCCCc-cEEeCCCCcEEeeEEEEEEec----cCCcEEEEEEeCC Confidence 1224667888888888999888 899999888764 78888887 3568888888754 No 121 >3EAF_A ABC transporter, substrate binding protein; 11229a2, PSI2, NYSGXRC, ABC transporter; 2.0A {Aeropyrum pernix} Probab=99.36 E-value=6.6e-17 Score=173.99 Aligned_cols=362 Identities=14% Similarity=0.105 Sum_probs=213.9 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLL-SNI--TLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il-~g~--~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) .++++||+++|.++.. ...+.....|++.|++++|..++++ +|+ ++++.+.|+.+++. ...+. T Consensus 2 ~~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~a~~~~n~~g~~~~~g~~~~v~~~~~d~~~~~~----~~~~~ 67 (391) T 3EAF_A 2 SLTINVGLLVDETGPT----------SDVGKGYSLGAELAFKYFNEKGIYTKDGVRVNINYIKRDYAYNPT----TAEEY 67 (391) T ss_dssp CEEEEEEEEECSSSTT----------HHHHHHHHHHHHHHHHHHHHHCEECTTCCEEEEEEEEEECTTCHH----HHHHH T ss_pred CCeEEEEEEecCCCCc----------chhchhhHHHHHHHHHHHHhcCceeeCCceeEEEEEEecCCCCHH----HHHHH Confidence 4578999999976532 1356678899999999999765432 344 56666677655432 22333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. +.++++||++ ++.....+...+...++|+|.+....+.+ .+++++++.+++ T Consensus 68 ~~~l~~------------------~~~v~~ii~~-~~~~~~~~~~~~~~~~ip~i~~~~~~~~~----~~~~~~~~~~~~ 124 (391) T 3EAF_A 68 YREFRD------------------RYGVIAIIGW-GTADTEKLSDQVDTDKITYISASYSAKLL----VKPFNFYPAPDY 124 (391) T ss_dssp HHCCCC------------------CTCCSEEEEC-CHHHHHHHHHHHHHHTCEEEESCCCGGGT----TSTTEECSSCCH T ss_pred HHHHHH------------------hcCceEEEec-ccHHHHHHHHHHHHcCCeEEEcCcchhhc----CCCceeecCCCH Confidence 333332 1478999986 55555566677888999999987654322 246778888888 Q NP_000836.2 200 SYQAQAMVDIV-TALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 200 ~~~~~~~~~~l-~~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ...+..+++++ ++++|+++++++. ++.++..+.+.|++.+++. ++++.....+.......+....+++++. .++++ T Consensus 125 ~~~~~~~~~~l~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~ 202 (391) T 3EAF_A 125 STQACSGLAFLASEFGQGKLALAYDSKVAYSRSPIGAIKKAAPSL-GLQVVGDYDLPLRATEADAERIAREMLA-ADPDY 202 (391) T ss_dssp HHHHHHHHHHHHHHHCSEEEEEEECTTCHHHHTTHHHHHHHTGGG-TEEEEEEEECCTTCCHHHHHHHHHHHHT-TCCSE T ss_pred HHHHHHHHHHHHHHhCCCeEEEEEcCCCccccCHHHHHHHHHHHc-CCEEEEeeecCCCCCcccHHHHHHHHHH-cCCCE Confidence 88888888887 5679999999985 5566777788888887765 3554332111110112334555666653 47888 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTI-LPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) +++...+..+..+++++++.|+. .+|+..+ |...............+.+.. ... .........+.. T Consensus 203 vi~~~~~~~~~~~~~~~~~~g~~--~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~ 269 (391) T 3EAF_A 203 VWCGNTISSCSLLGRAMAKVGLD--AFLLTNV-WGFDERSPQLIGEGGYGKVFGISPF----------IYPMFGQDVEGI 269 (391) T ss_dssp EEECSCHHHHHHHHHHHHHHTCC--CEEEECG-GGCSTTHHHHHCGGGTTSEEEEESB----------CCGGGCTTCHHH T ss_pred EEECCCHHHHHHHHHHHHHcCCC--cEEEecc-ccCCccchHHhccccccceeeeecc----------ccccCCcCCHHH Confidence 87765666777889999888874 3455443 221110000001111221110 000 000000001111 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST 436 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~ 436 (908) ..|.+.+++ +... ...+..++..+||+++++++|++++..... .. T Consensus 270 ~~f~~~~~~-~~~~------------------------~~~~~~~~~~~yda~~~~~~al~~~~~~~~----------~~ 314 (391) T 3EAF_A 270 QTIFEAARM-NGVS------------------------EDQINLRVVQGFVNVWLLIKAIESVTSQDL----------QE 314 (391) T ss_dssp HHHHHHHHH-TTCC------------------------GGGCCHHHHHHHHHHHHHHHHHTTSCHHHH----------HH T ss_pred HHHHHHHHH-cCCC------------------------cccCChhHHHHHHHHHHHHHHHHHhccccc----------cc Confidence 122222222 1100 011235677899999999999998753210 01 Q NP_000836.2 437 IDGKELLGYIRAVNFN--GSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 437 ~~~~~l~~~l~~~~f~--G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) .+++.+.++|++..|. |.+|+++.|+++|++. ..+.+.+++. ++.++.++.|... T Consensus 315 ~~~~~l~~~l~~~~~~~~G~~g~~i~f~~~~~~~~~~~~i~~~~~---~~~~~~v~~~~~~ 372 (391) T 3EAF_A 315 RGGEALKEALEANTFDLGGITADTIDYEPGFHLAYRKVFIIKLGE---NGELQLMGKFEAP 372 (391) T ss_dssp HTHHHHHHHHHHCCBCSTTCBSSCBCCBTTBCCCCCCEEEEEECT---TSSEEEEEEECCC T ss_pred cChHHHHHHHHhCCCCCCCccccceEecCCCccccceEEEEEECC---CCeEEeCcceeCc Confidence 2456778888877787 7765469999877653 4566666652 2467888888754 No 122 >5UOW_C N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate; membrane protein; HET: NAG, GLU, BMK; 4.5A {Xenopus laevis} Probab=99.36 E-value=6.8e-17 Score=192.22 Aligned_cols=336 Identities=18% Similarity=0.285 Sum_probs=221.7 Template_Neff=11.300 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.+ ....|++.|++++|+++ .+.++++.+.|+..++.. ...+.+.+++ T Consensus 2 ~~~i~Ig~~~p~~------------------~~~~~~~~a~~~~n~~g---~~~~i~l~~~d~~~~~~~-~~~~~~~~~~ 59 (814) T 5UOW_C 2 PKIVNIGAVLSTK------------------KHEQIFREAVNQANKRH---FTRKIQLNATSVTHRPNA-IQMALSVCED 59 (814) T ss_dssp CSCEEEEEEESCH------------------HHHHHHHHHHHHHHHHS---CTTTCCEEEEEEECCSSH-HHHHHCCCCC T ss_pred CCccceEEEecCc------------------hHHHHHHHHHHHHHHhc---cCCCeeeeceeecCCCCH-HHHHHHHHHH Confidence 4678999999865 24578999999999865 246677777776544322 1112333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-----IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-----~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) +.. +++++++|+.++..+ ..++..+...++|++++.+..+.+.+...+++++++.+ T Consensus 60 l~~-------------------~~v~~iig~~~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~l~~~~~~~~~~~~~~ 120 (814) T 5UOW_C 60 LIS-------------------SQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVP 120 (814) T ss_dssp TTT-------------------TCCSCEEECCCSSCCSSCTTSHHHHHHHHHTCCEEESSCCCGGGCCTTTCSSEEESSC T ss_pred HHh-------------------cCceEEEEcCCCCCCCCCCCchhHHhhhhcCCCEEEccCCCccccCCccCchhhcCCC Confidence 322 478899998877766 56667888899999998876665544335788999999 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v 277 (908) ++...++++++++++++|+++++++.+++++....+.+++.+++. ++++.....+. .+..++...++++++ .++|+ T Consensus 121 ~~~~~~~~~~~~~~~~~~~~i~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~l~~-~~~~~ 196 (814) T 5UOW_C 121 PYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEK-ESKADKVLQFE--PGTKNLTALLLEAKE-LEARV 196 (814) T ss_dssp CTTTHHHHHHHHHHHHTCCCCEEEEESSHHHHHHHHHHHHHHHHS-SCCCSCEEEEC--SSCSCCHHHHHHHHH-SSCCE T ss_pred CHHHHHHHHHHHHHHcCCcEEEEEEecCcchHHHHHHHHHHHHhc-ccccceeeccC--CCCccHHHHHHHHHh-cCCeE Confidence 999999999999988899999999987788888888888888775 45554333232 223456667777763 57899 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRN 356 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 356 (908) |++.+.......+++++++.|+.. .+.|++.+.+.... .......+.+.. T Consensus 197 vv~~~~~~~~~~~l~~~~~~g~~~~~~~~~~~~~~~~~~----~~~~~~~~~~~~------------------------- 247 (814) T 5UOW_C 197 IILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGS----ALRYAPDGIIGL------------------------- 247 (814) T ss_dssp EEEECCHHHHHHHHHHHHHTTTTSTTCEEEECHHHHSTH----HHHTCCTTCEEE------------------------- T ss_pred EEEeCCHHHHHHHHHHHHhcCCCCCCeEEEEecCCCCCc----hhhcCCCceEEE------------------------- Confidence 888877777788899988888753 34555543221110 000000000000 Q NP_000836.2 357 VWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY-IGLCPRM- 434 (908) Q Consensus 357 ~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~-~~~~~~~- 434 (908) . . ..+..++..+|||++++++++++.....+... ...|... T Consensus 248 ----~----~-----------------------------~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~~~~~~~~~~~ 290 (814) T 5UOW_C 248 ----Q----L-----------------------------INGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNT 290 (814) T ss_dssp ----E----E-----------------------------SSSSCHHHHHHHHHHHHHHHHHHHTTSCCCCCCCSSSTTCC T ss_pred ----E----e-----------------------------cCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCCCCcCCCC Confidence 0 0 00123456789999999999998765422110 0112111 Q NP_000836.2 435 -STIDGKELLGYIRAV-NFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 -~~~~~~~l~~~l~~~-~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...++..+.+.+++. .|+|.+| ++.||++|++. ..+.+.+++ ++.+..+|.|+.. T Consensus 291 ~~~~~~~~l~~~l~~~~~~~G~~g-~~~fd~~g~~~~~~~~i~~~~----~~~~~~v~~~~~~ 348 (814) T 5UOW_C 291 NIWKTGPLFKRVLMSSKYPDGVTG-RIEFNEDGDRKFAQYSIMNLQ----NRKLVQVGIFDGS 348 (814) T ss_dssp SCCSSSHHHHHHHHTCCCCCCSSC-CCCBCTTSCBCCCCEEEEECC----TTSCEEEEEECSS T ss_pred ccccchHHHHHHHHhcCCCCCccc-ceEECCCCceeeeEEEEEEcc----CCceEEEEEEeCC Confidence 012445677777754 6788888 89999999875 678888886 3578999999864 No 123 >3LOP_A Substrate binding periplasmic protein; Substrate-binding, Protein Structure Initiative II(PSI; HET: EDO; 1.55A {Ralstonia solanacearum} Probab=99.36 E-value=7.1e-17 Score=171.86 Aligned_cols=352 Identities=11% Similarity=0.091 Sum_probs=207.6 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||+++|.++... ..+.....+++.|++++|+++++. |+++++...|+.+++. ...+.+++ T Consensus 3 ~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~n~~g~~~-g~~v~~~~~d~~~~~~----~~~~~~~~ 67 (364) T 3LOP_A 3 LADISVIQSLPLSGSQA----------VTGRALNAGARLYFDWLNLNGGIN-GETIRLVARDDEQKIE----QTVRNVRD 67 (364) T ss_dssp --CEEEEEEECSSSTTH----------HHHHHHHHHHHHHHHHHHHTTTBT-TBCEEEEEEECTTCHH----HHHHHHHH T ss_pred cccEEEEEecCCCCCch----------HHhHHHHHHHHHHHHHHHHcCCcC-CEEEEEEEecCCCCHH----HHHHHHHH Confidence 46789999999865321 245678899999999999876543 6778887777655532 22333333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVA--NILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va--~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++. ..++++++++.++....... ..+...++|+|.++...+.+. ..++++++.++.. T Consensus 68 l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~---~~~~~~~~~~~~~ 126 (364) T 3LOP_A 68 MAR------------------VDNPVALLTVVGTANVEALMREGVLAEARLPLVGPATGASSMT---TDPLVFPIKASYQ 126 (364) T ss_dssp HHH------------------HSCEEEEECCCCHHHHHHHHHTTHHHHHTCCEESCSCCCGGGG---SCTTEECCSCCHH T ss_pred HHh------------------hcCceEEEEecCCHHHHHHHhhhhHHhcCCCEEeccCCCcccC---CCCceEEccCCHH Confidence 332 14788888876655444443 567788999998876554332 1467788888888 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) ..++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++++|++ T Consensus 127 ~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii~ 202 (364) T 3LOP_A 127 QEIDKMITALVTIGVTRIGVLYQEDALGKEAITGVERTLKAH-ALAITAMASYP--RNTANVGPAVDKLLA-ADVQAIFL 202 (364) T ss_dssp HHHHHHHHHHHHTTCCCEEEEEETTHHHHHHHHHHHHHHHTT-TCCCSEEEEEC--TTSCCCHHHHHHHHH-SCCSEEEE T ss_pred HHHHHHHHHHHHhCCCEEEEEEecCchhHHHHHHHHHHHHHC-CCceeEEeeeC--CCCCChHHHHHHHHh-CCCCEEEE Confidence 888889998877899999999966667777888888888775 35544322221 122344555666653 47888777 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE-EIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~-~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ...+..+..+++++++.|+. ..+++.+.+...... .... ....+....... ........+....| T Consensus 203 ~~~~~~~~~~~~~~~~~g~~--~~ii~~~~~~~~~~~-~~~~~~~~~~~~~~~~~-----------~~~~~~~~~~~~~f 268 (364) T 3LOP_A 203 GATAEPAAQFVRQYRARGGE--AQLLGLSSIDPGILQ-KVAGLDAVRGYSLALVM-----------PNPGKSVNPVIREF 268 (364) T ss_dssp ESCHHHHHHHHHHHHHTTCC--CEEEECTTSCHHHHH-HHHCHHHHTTCEEEECS-----------CCTTCTTSHHHHHH T ss_pred ECCHHHHHHHHHHHHHCCCC--ceEEEecCCChHHHH-HHhCccccccEEEEEEe-----------cCCCcCCCHHHHHH Confidence 76566677888888887773 456665543321110 0000 011221110000 00000001111223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDG 439 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~ 439 (908) .+.+++.+.. ...++.++..+||++++++.|+++.... .++ T Consensus 269 ~~~~~~~~~~-------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~~--------------~~~ 309 (364) T 3LOP_A 269 NRARAAVGAK-------------------------DVDLSFRAVEGFVAAKVLAEAIRRAGPK--------------PTR 309 (364) T ss_dssp HHHHHHHTCT-------------------------TCCCCHHHHHHHHHHHHHHHHHHHHCSS--------------CCH T ss_pred HHHHHHhCCC-------------------------CCCCCHHHHHHHHHHHHHHHHHHHHCCC--------------CCH Confidence 3222221110 0112345778999999999999886421 234 Q NP_000836.2 440 KELLGYIRAV-NFNGS-AGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWT 492 (908) Q Consensus 440 ~~l~~~l~~~-~f~G~-~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~ 492 (908) +.+.++|++. .|... .+ ++.|++++++. ..+.+++++ .+.++.++.|+ T Consensus 310 ~~~~~~l~~~~~~~~~g~~-~~~f~~~~~~~~~~~~~~~~~----~~~~~~~~~~~ 360 (364) T 3LOP_A 310 EQVRHALTELRDYDVGGGF-TVDFTDRSRPGSHYIELGVVG----PNGLVIQEGHH 360 (364) T ss_dssp HHHHHHHHTCEEEESSTTC-EEECSSTTSCSCCCCEEEEEC----TTSCEEEC--- T ss_pred HHHHHHHHhCCCCcCCCCe-eeecCCCCCcccCeEEEEEEC----CCceEeecCCC Confidence 5677777664 46421 23 68888766543 456666666 24566677665 No 124 >5IOV_B GluN1, GLY-GLY-GLU-GLU; ligand-gated ion channel, synaptic transmission; HET: QEM, GLU, GLY; 7.5A {Xenopus laevis} Probab=99.35 E-value=7.4e-17 Score=192.20 Aligned_cols=341 Identities=15% Similarity=0.193 Sum_probs=215.4 Template_Neff=11.300 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPD--LLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~--il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) .....++++||+++|.++ . ++|++++|++++ .+++..+.+.+.|+.+++..+.+ T Consensus 23 ~~~~~~~i~Ig~~~~~~g-------------~---------~~A~~~iN~~~g~~~~~~~~~~~~~~d~~~~~~~~~~-- 78 (825) T 5IOV_B 23 YAQKHPNMDIAVILVGTT-------------E---------EVAIKDVHEKDDFHHLPVTPRVELVTMQESDPKSIIT-- 78 (825) T ss_pred HHhhCCCCcEEEEEecCc-------------e---------eeeecccccCCCcccCCCCceeeEecCCCCCHHHHHH-- Confidence 356678999999999763 1 889999998876 44454455555666655443333 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASS--VSIMVANILRLFKIPQISYASTAPE-LSDNTRYDFF 192 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~--~~~~va~~~~~~~iP~Is~~~~~~~-l~~~~~~~~~ 192 (908) .+++++. .+++++++ |+.++. .+..++..+...++|+|++.+..+. +++...++++ T Consensus 79 --~~~~l~~------------------~~~v~avi~G~~~s~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~ 138 (825) T 5IOV_B 79 --RICDLMS------------------DKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMF 138 (825) T ss_pred --HHHHhcc------------------cCCcEEEEEcCCCChHHHHHHHHHHHHhhCCCEEEecCCCccccccccCCeeE Confidence 3333332 14788876 987765 4456667777899999996544332 2222357889 Q NP_000836.2 193 SRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLE 271 (908) Q Consensus 193 ~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~ 271 (908) +++.|++...+.++++++.+++|+++++++.+++++....+.+++.+++. +.++.....+..+. ...+....++++++ T Consensus 139 ~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 217 (825) T 5IOV_B 139 FQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRSTIENS-FVGWELEEVIHLDMSLDDIDSKIQNQLKK 217 (825) T ss_pred EEcCCCHHHHHHHHHHHHHHcCCeEEEEEEEcCCCchhHHHHHHHHHHhc-cCceEEEEEEEccCChhhHHHHHHHHHHh Confidence 99999998889999999988899999999987778888888888877764 34443222221100 12234455555653 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTL 350 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~ 350 (908) .++|+|++.+....+..+++++++.|+.. ++.|+..+.+...... .......+.. T Consensus 218 -~~~~~iv~~~~~~~~~~~l~~~~~~g~~~~~~~~i~~~~~~~~~~~--~~~~~~~~~~--------------------- 273 (825) T 5IOV_B 218 -LQSPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDT--VPDEFPTGLI--------------------- 273 (825) T ss_pred -cCCCEEEEECCHHHHHHHHHHHHHcCCCCCCeEEEeeecCCCCCCC--CCCcCCCCeE--------------------- Confidence 47899888777777888999998888753 3456654432211000 0000000000 Q NP_000836.2 351 ANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG--YI 428 (908) Q Consensus 351 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~--~~ 428 (908) .. .+. ..+..++..+|||++++++|++++....+.. .. T Consensus 274 --------~~-----~~~---------------------------~~~~~~~~~~yDav~~~a~al~~~~~~~~~~~~~~ 313 (825) T 5IOV_B 274 --------SV-----SYD---------------------------EWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSK 313 (825) T ss_pred --------EE-----Eee---------------------------cCCCCcchhHHHHHHHHHHHHHHHHHhcCCCCCCC Confidence 00 000 0012346789999999999999986542110 00 Q NP_000836.2 429 GLCPRM---STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAP-GRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 429 ~~~~~~---~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~-~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ..|... ...++..+.+.|++.+|.| | ++.|+++|++. ..+.+++++. ++.+..+|.|... T Consensus 314 ~~~~~~~~~~~~~~~~l~~~l~~~~f~G--G-~~~f~~~g~~~~~~~~i~~~~~---~~~~~~~~~~~~~ 377 (825) T 5IOV_B 314 SSCNNIQESRVYEAHMLKRYLINVTFEG--R-DLSFSEDGYQMHPKLVIILLNQ---ERKWERVGKYKDR 377 (825) T ss_pred cccccCCcchhHhHHHHHHHHhcccccC--c-ceeeCCCCccceeeEEEEEeCC---CCceEEEEEEeCC Confidence 122211 1124567888888889988 7 89999999884 5778888863 2568888888654 No 125 >5WEO_A Glutamate receptor 2,Voltage-dependent calcium channel; Ion channel, TRANSPORT PROTEIN; HET: CYZ, GLU;{Rattus norvegicus} Probab=99.33 E-value=1.3e-16 Score=194.97 Aligned_cols=356 Identities=15% Similarity=0.187 Sum_probs=224.0 Template_Neff=11.100 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~~~~ 122 (908) ++++||+++|.++. ....|++.|++++|++ |+++++...|+. +++.. +.+.+++ T Consensus 1 ~~i~Ig~~~~~sg~----------------~~~~~~~~a~~~iN~~-----g~~l~~~~~d~~~~~~~~----a~~~~~~ 55 (1034) T 5WEO_A 1 NSIQIGGLFPRGAD----------------QEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFA----VTNAFCS 55 (1034) T ss_dssp CEEEEEEEECTTCH----------------HHHHHHHHHHHHHCCS-----SSEEEEEEEECCSSCHHH----HHHHHHH T ss_pred CceeeeeeecCCCh----------------HHHHHHHHHHHhhhcC-----CceeeeeeEecCCCCHHH----HHHHHHH Confidence 36899999998752 5678999999999985 477888888876 44332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +++ +++++++|+.++....+++..+.+.++|++++...++ ..+++++++.|+. T Consensus 56 l~~-------------------~~v~~viG~~~s~~~~~~~~~~~~~~ip~i~~~~~~~-----~~~~~~~~~~~~~--- 108 (1034) T 5WEO_A 56 QFS-------------------RGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-----GTHPFVIQMRPDL--- 108 (1034) T ss_dssp HHH-------------------HTCSEEEECCCTTTHHHHHHHHHHHCCCEEECSSCCS-----SCCTTEEECCCCC--- T ss_pred HHH-------------------cCeeEEEecCChHHHHHHHHHHcccCCeEEeCCCCCC-----CCCCeEEEecCch--- Confidence 332 5789999998887777888888899999998875433 2468899998873 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPR--EPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +.++++++++++|+++++++ +++++....+.+.+.+++. ++++.....+.. +.+..++.+.++++++ .++|+|++ T Consensus 109 ~~~~~~~l~~~~~~~v~iv~-~~~~g~~~~~~~~~~~~~~-g~~v~~~~~~~~~~~~~~~d~~~~~~~i~~-~~~~~vv~ 185 (1034) T 5WEO_A 109 KGALLSLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEK-KWQVTAINVGNINNDKKDETYRSLFQDLEL-KKERRVIL 185 (1034) T ss_dssp HHHHHHHHHHHTCSEEEEEE-CGGGCSHHHHHHHHHHHHT-TCEEEEEECTTSCGGGTTHHHHHHHHHHTT-TTCCEEEE T ss_pred HHHHHHHHHHhCCCEEEEEE-eCCchHHHHHHHHHHHhhc-CCeEEEEEecCCCCCCCccchHHHHHHHhh-cCCcEEEE Confidence 56777888788999999999 6677777777788777764 455543322210 0122456677777764 57899988 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF 359 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~~-~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 359 (908) ......+..+++++++.|+.. .+.|++.+.+...... ........+....... ....+....+ T Consensus 186 ~~~~~~~~~~~~~~~~~g~~~~~~~~i~~~~~~~~~~~-~~~~~~~~~~~~~~~~---------------~~~~~~~~~f 249 (1034) T 5WEO_A 186 DCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL-LKIQFGGAEVSGFQIV---------------DYDDSLVSKF 249 (1034) T ss_dssp ESCHHHHHHHHHHHHHHTTTSTTCEEEECSSBTTSSCC-STTTTSSSEEEEEESS---------------CTTSHHHHHH T ss_pred eCCHHHHHHHHHHHHHhCCCcCCeEEEEEeCCCCCCch-HhcccCCceEEEEEEe---------------eCCcHHHHHH Confidence 877777888999999988854 3556665422211100 0000001111111000 0011122223 Q NP_000836.2 360 AEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCP----GYIGLCPRM- 434 (908) Q Consensus 360 ~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~----~~~~~~~~~- 434 (908) .+.+++.++..... . ....++.++..+|||++++++|++++...... .....|... T Consensus 250 ~~~~~~~~~~~~~~---------~----------~~~~~~~~~~~~yda~~~~~~al~~~~~~~~~~~~~~~~~~~~~~~ 310 (1034) T 5WEO_A 250 IERWSTLEEKEYPG---------A----------HTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANP 310 (1034) T ss_dssp HHHHHTSCTTTSTT---------C----------SSSSCCHHHHHHHHHHHHHHHHHHHHHHTTCCCCCCSCCCCTTCTT T ss_pred HHHHHhcccccCCC---------c----------CCCCCchHHHHHHHHHHHHHHHHHHHHHhccccccCCCCCCCccCC Confidence 33333332210000 0 00123456788999999999999998643210 000112110 Q NP_000836.2 435 --STIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPG-RYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 435 --~~~~~~~l~~~l~~~~f~G~~G~~v~Fd~~G~~~~-~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) ...+++.+.+++++..|.|..| ++.|+++|++.. .+.+.+++ ++.+..+|.|... T Consensus 311 ~~~~~~~~~l~~~l~~~~~~g~~G-~~~f~~~~~~~~~~~~i~~~~----~~~~~~~~~~~~~ 368 (1034) T 5WEO_A 311 AVPWGQGVEIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELK----TNGPRKIGYWSEV 368 (1034) T ss_dssp CCCCTHHHHHHHHHTTCCCEETTE-ECEECTTSCEESCEEEEEEEC----SSSEEEEEEEESS T ss_pred CCCcccHHHHHHHHHhcCcCCCCC-ceEeCCCCcEEeeEEEEEEec----cCCceEEEEEeCC Confidence 1224667888888888999888 899998888754 67888887 3567888888753 No 126 >4DQD_A Extracellular ligand-binding receptor; structural genomics, PSI-Biology, protein structure; HET: PPY, PG4, GOL; 1.601A {Rhodopseudomonas palustris} Probab=99.31 E-value=1.9e-16 Score=168.26 Aligned_cols=348 Identities=14% Similarity=0.130 Sum_probs=203.5 Template_Neff=12.200 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||+++|.++... ..+.....+++.+++++| |.++++.+.|+..++.. ..+.+++ T Consensus 2 ~~~~~Ig~~~~~~~~~~----------~~~~~~~~g~~~a~~~~~-------g~~~~~~~~~~~~~~~~----~~~~~~~ 60 (363) T 4DQD_A 2 NAEIKIGITMSASGPGA----------ALGQPQSKTVAALPKEIG-------GEKVTYFALDDESDPTK----AAQNARK 60 (363) T ss_dssp -CCEEEEEEECCSSTTH----------HHHHHHHHHGGGSCSEET-------TEEEEEEEEECTTCHHH----HHHHHHH T ss_pred CcceEEEEEEcCCCCch----------hcChhhHHHHHHchHhhC-------CEEEEEEEEcCCCCHHH----HHHHHHH Confidence 35789999999865321 245667888888888875 35577777776555332 2233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELS-DNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~-~~~~~~~~~~~~~~~~~ 201 (908) ++. .++++++|++.++.....+...+...++|+|......+.+. .....++++++.++... T Consensus 61 l~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 122 (363) T 4DQD_A 61 LLS------------------EEKVDVLIGSSLTPVSLPLIDIAAEAKTPLMTMAAAAILVAPMDERRKWVYKVVPNDDI 122 (363) T ss_dssp HHH------------------TSCCSEEECCSSHHHHHHHHHHHHHTTCCEEECCCCGGGTCSCCTTGGGEEECSCCHHH T ss_pred HHh------------------hcCCCEEEecCCchhHHHHHHHHHHcCCCEEEccCccccccCcccccCceeEecCCHHH Confidence 332 14789999877665555666777888999998876554322 11134677888898888 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .++.+++++.+.+|+++++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|++++. T Consensus 123 ~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~i~~~ 198 (363) T 4DQD_A 123 MAEAIGKYIAKTGAKKVGYIGFSDAYGEGYYKVLAAAAPKL-GFELTTHEVYA--RSDASVTGQVLKIIA-TKPDAVFIA 198 (363) T ss_dssp HHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-TCEECCCEEEC--TTCSCCHHHHHHHHH-TCCSEEEEE T ss_pred HHHHHHHHHHHhCCCeEEEEEecCcchHHHHHHHHHHHHHc-CcEEeeeeeeC--CCCCccHHHHHHHHh-hCCCEEEEe Confidence 88899999877799999999966667778888888888775 35544322222 112334555666653 578888877 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-ANNRRNVWFA 360 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~ 360 (908) .....+..+++++++.|+. .+|++.+.+...... ........+.+..... +......... ...+....|. T Consensus 199 ~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~------~~~~~~~~~~~~~~~~~~~f~ 269 (363) T 4DQD_A 199 SAGTPAVLPQKALRERGFK--GAIYQTHGVATEEFI-KLGGKDVEGAIFAGEA------FSGAEDMPADSPFRKVKARFV 269 (363) T ss_dssp CCSGGGHHHHHHHHHTTCC--SEEECCGGGCSHHHH-HHHGGGGTTCEEEECH------HHHGGGSCTTCHHHHHHHHHH T ss_pred cCCccchHHHHHHHHcCCC--ceEEecccccCHHHH-HhhcccccccEEeccc------ccCCCCCCCCCchhHHHHHHH Confidence 6555577888888888874 355555433322110 0001112232211100 0000000000 0000111122 Q NP_000836.2 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGK 440 (908) Q Consensus 361 ~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~ 440 (908) +.+++.++ ...++.++..+||++++++.+++++....... ...++. T Consensus 270 ~~~~~~~~--------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~~--------~~~~~~ 315 (363) T 4DQD_A 270 DAYKAANG--------------------------GAAPTIFGVHLWDSMTLVENAIPAALKAAKPG--------TPEFRA 315 (363) T ss_dssp HHHHHHTT--------------------------TCCCCTHHHHHHHHHHHHHHHHHHHHHHCCTT--------SHHHHH T ss_pred HHHHHHcC--------------------------CCCCCCccccHHHHHHHHHHHHHHHHHhcCCC--------CHHHHH Confidence 22221110 01234567889999999999998875431100 112455 Q NP_000836.2 441 ELLGYIRAV-NFNGSAGTPVTFNENG---DAPGRYDIFQYQ 477 (908) Q Consensus 441 ~l~~~l~~~-~f~G~~G~~v~Fd~~G---~~~~~~~i~~~~ 477 (908) .+.+.|++. .|.|.+| .+.|+..+ .+...+.+++++ T Consensus 316 ~l~~~l~~~~~~~g~~g-~~~~~~~~~~~~~~~~~~i~~~~ 355 (363) T 4DQD_A 316 AIRDQIEKSKDLALNNG-LSNMTPDNHNGYDERSAFLIEIR 355 (363) T ss_dssp HHHHHHTTCCSEEETTE-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHhcccccccCC-ccccCCCCCCCCCccceEEEEEE Confidence 677888876 7888877 89997542 222356666665 No 127 >3SG0_A Extracellular ligand-binding receptor; structural genomics, PSI-Biology, protein structure; HET: 173, MSE; 1.201A {Rhodopseudomonas palustris} Probab=99.28 E-value=3.9e-16 Score=167.41 Aligned_cols=350 Identities=14% Similarity=0.122 Sum_probs=203.1 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||+++|.++... ..+.....+++.+++++| |+++++.+.|+.+++. ...+.+ T Consensus 23 ~~~~~~~Ig~i~~~~~~~~----------~~~~~~~~g~~~a~~~~~-------g~~~~~~~~~~~~~~~----~~~~~~ 81 (386) T 3SG0_A 23 AAQAEIKIGITMSASGPGA----------ALGQPQSKTVAALPKEIG-------GEKVTYFALDDESDPT----KAAQNA 81 (386) T ss_dssp --CCCEEEEEEECCSSTTH----------HHHHHHHHHGGGSCSEET-------TEEEEEEEEECTTCHH----HHHHHH T ss_pred ccCCceEEEEEEcCCCCcc----------ccchhHHHHHHHcchhhC-------CEEEEEEEEcCCCCHH----HHHHHH Confidence 4567899999999875321 245567788888888765 3456666667654432 223333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELS-DNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~-~~~~~~~~~~~~~~~ 199 (908) ++++. .++++++|++.++.....+...+...++|+|.+....+.+. .....++++++.+++ T Consensus 82 ~~~~~------------------~~~~~~ii~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~~~~~~~~~~~~~~~~~~~ 143 (386) T 3SG0_A 82 RKLLS------------------EEKVDVLIGSSLTPVSLPLIDIAAEAKTPLMTMAAAAILVAPMDERRKWVYKVVPND 143 (386) T ss_dssp HHHHH------------------TSCCSEEECCSSHHHHHHHHHHHHHTTCCEEECCCCGGGTCSCCTTGGGEEECSCCH T ss_pred HHHHh------------------cCCCCEEEccCCchhHHHHHHHHHHcCCCEEEcCCcccccCCcccccCceeEecCCH Confidence 43332 14788999877665555666777888999998876554322 111346788888888 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) ...++.+++++.+.+|++|++++.++.++..+.+.+++.+++. ++++.....+. ....+....+++++. .++|+++ T Consensus 144 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~ii 219 (386) T 3SG0_A 144 DIMAEAIGKYIAKTGAKKVGYIGFSDAYGEGYYKVLAAAAPKL-GFELTTHEVYA--RSDASVTGQVLKIIA-TKPDAVF 219 (386) T ss_dssp HHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-TCEECCCEEEC--TTCSCCHHHHHHHHH-TCCSEEE T ss_pred HHHHHHHHHHHHHhCCCEEEEEeecCccchhHHHHHHHHHHHc-CCEEeeeEeeC--CCCCChHHHHHHHHh-hCCCEEE Confidence 8888899999877799999999966667778888888888775 35543322221 122345556666663 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTL-ANNRRNVW 358 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~ 358 (908) +......+..+++++++.|+. ..|++.+.+...... ........+.+..... +......... ...+.... T Consensus 220 ~~~~~~~~~~~~~~~~~~g~~--~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~------~~~~~~~~~~~~~~~~~~~ 290 (386) T 3SG0_A 220 IASAGTPAVLPQKALRERGFK--GAIYQTHGVATEEFI-KLGGKDVEGAIFAGEA------FSGAEDMPADSPFRKVKAR 290 (386) T ss_dssp EECCSGGGHHHHHHHHHTTCC--SEEECCGGGCSHHHH-HHHGGGGTTCEEEECH------HHHGGGSCTTCHHHHHHHH T ss_pred EecCCccchHHHHHHHHcCCC--ceEEeccccCCHHHH-HhhccccCccEEeecc------cCCCCCCCCCCchhHHHHH Confidence 776555577888888888874 355555433221110 0001112222211100 0000000000 00001111 Q NP_000836.2 359 FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTID 438 (908) Q Consensus 359 ~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~ 438 (908) |.+.+.+.+. ...+..++..+||++++++++++++...... ....+ T Consensus 291 f~~~~~~~~~--------------------------~~~~~~~~~~~yda~~~~~~a~~~~~~~~~~--------~~~~~ 336 (386) T 3SG0_A 291 FVDAYKAANG--------------------------GAAPTIFGVHLWDSMTLVENAIPAALKAAKP--------GTPEF 336 (386) T ss_dssp HHHHHHHHTT--------------------------TCCCCHHHHHHHHHHHHHHHHHHHHHHHCCT--------TSHHH T ss_pred HHHHHHHHhC--------------------------CCCCCCcchhHHHHHHHHHHHHHHHHHhcCC--------CCHHH Confidence 2221211110 0113356788999999999999887542110 01124 Q NP_000836.2 439 GKELLGYIRAV-NFNGSAGTPVTFNENG---DAPGRYDIFQYQ 477 (908) Q Consensus 439 ~~~l~~~l~~~-~f~G~~G~~v~Fd~~G---~~~~~~~i~~~~ 477 (908) ++.+.++|++. .|.|.+| .+.|+..+ .+...+.+.+++ T Consensus 337 ~~~l~~~l~~~~~~~g~~g-~~~~~~~~~~~~~~~~~~v~~~~ 378 (386) T 3SG0_A 337 RAAIRDQIEKSKDLALNNG-LSNMTPDNHNGYDERSAFLIEIR 378 (386) T ss_dssp HHHHHHHHTTCCSEEETTE-EECCCSSCSSCCCGGGCEEEEEE T ss_pred HHHHHHHHHhCcCccCCCC-ccccCCCCCCCccccceEEEEEe Confidence 56677888876 7888877 89997542 222355666665 No 128 >5ERE_A Extracellular ligand-binding receptor; Solute Binding Protein, Tandem PAS; HET: MSE; 2.0A {Desulfohalobium retbaense DSM 5692} Probab=99.27 E-value=4.6e-16 Score=176.57 Aligned_cols=327 Identities=15% Similarity=0.220 Sum_probs=209.8 Template_Neff=12.000 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) .++||+++|.++... ..+.....|++.|++++| .++++.+.|+++++..+. +.+++++ T Consensus 1 ~i~ig~~~p~~g~~~----------~~~~~~~~g~~~a~~~~g--------~~v~~~~~d~~~~~~~~~----~~~~~l~ 58 (568) T 5ERE_A 1 KPVVGVILPFSSAFE----------DIAVEQQRAVELALAESG--------SAFEIVFKDGGADVDTAV----QAFQDLV 58 (568) T ss_dssp CCEEEEEECCSSTTH----------HHHHHHHHHHHHHHHHHT--------CSSEEEEEECCSSHHHHH----HHHHHHH T ss_pred CCEEEEEeCCCCCcH----------HHHHHHHHHHHHHHHHcC--------CcEEEEEEcCCCCHHHHH----HHHHHHH Confidence 378999999987531 356778899999999874 457778888877654332 3333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) .+ +++++++++ .++..+..++..+...++|+|.+.+..+.+.+ .++++++.++....+. T Consensus 59 ~~-----------------~~~~~~i~~-~~s~~~~~~~~~~~~~~ip~i~~~~~~~~~~~---~~~~~~~~~~~~~~~~ 117 (568) T 5ERE_A 59 RS-----------------QENLAAVVS-CSSWASSAIHPLAAEKDIFHVAIGSAALKRTE---PGHTIRLTVGVQQEQE 117 (568) T ss_dssp HH-----------------CTTEEEEEE-ESHHHHHHHHHHHHHTTCEEEEESCTTCCCCS---TTCCEECSCCHHHHHH T ss_pred hc-----------------CCCcEEEEe-CCcHHHHhHHHHHHhCCCEEEEecCCCccccC---CCCeEEccCChHHHHH Confidence 21 025666665 56666667778888999999998776554432 3778999998888888 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANE 284 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~~ 284 (908) ++++++. +|+++++++.++.++....+.+++.++.. +.....+. .+..++...+++++. .++|+|++.+ . T Consensus 118 ~~~~~~~--~~~~v~i~~~~~~~~~~~~~~~~~~~~~~----~~~~~~~~--~~~~~~~~~~~~~~~-~~~~~v~~~~-~ 187 (568) T 5ERE_A 118 QLAAYLT--DFERIAVLAMDNNLGSSWIRMLEDRFPKQ----VVAAQEYN--PQQMDIAAQLATIKA-RDSEALVLIS-A 187 (568) T ss_dssp HHHHHHT--TCSSEEEEEESSHHHHHHHHHHHHHCTTT----EEEEEEEC--TTTCCCHHHHHHHHT-TTCSEEEEEC-S T ss_pred HHHHHHc--CCCEEEEEEecChhHHHHHHHHHHHcCCc----eeEEeeeC--ccCCCHHHHHHHHHh-CCCCEEEEEc-h Confidence 8888886 89999999977777777777776665431 11112222 123356666777763 5788887776 4 Q NP_000836.2 285 DDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWE 364 (908) Q Consensus 285 ~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 364 (908) ..+..+++++++.|+. +.|++.+.+...... .......+.+...+ . .+....|.+.++ T Consensus 188 ~~~~~~l~~~~~~g~~--~~~~~~~~~~~~~~~--~~~~~~~g~~~~~~-----------------~-~~~~~~~~~~~~ 245 (568) T 5ERE_A 188 GEAATIAKQARQAGIK--AQLVGTRPIQRAEVL--AASAFTNGLVYTYP-----------------S-YNQDHPFMSAFT 245 (568) T ss_dssp TTHHHHHHHHHHTTCC--CEEEECGGGCCHHHH--HTHHHHTTCEEEEE-----------------C-CCTTSHHHHHHH T ss_pred HHHHHHHHHHHHCCCC--CEEEeCChhcCHHHH--HhhhhcCeeEEEcC-----------------C-CcCCcHHHHHHH Confidence 5677888888888773 456665433221110 00111122111100 0 001111222222 Q NP_000836.2 365 ENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLG 444 (908) Q Consensus 365 ~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 444 (908) +.++ ..++.++..+|||++++++|+++... +++.+.+ T Consensus 246 ~~~~---------------------------~~~~~~~~~~yda~~~~~~al~~~~~----------------~~~~~~~ 282 (568) T 5ERE_A 246 DRYG---------------------------LEPGFFGVEAYDLCTTLSRALEQGRQ----------------TPKALFE 282 (568) T ss_dssp HHHS---------------------------SCCCHHHHHHHHHHHHHHHHHHTTCC----------------SHHHHHH T ss_pred HHHC---------------------------CCCChHHHHHHHHHHHHHHHHHhcCC----------------CHHHHHH Confidence 2221 11235678899999999999987531 3446777 Q NP_000836.2 445 YIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQ 494 (908) Q Consensus 445 ~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~~ 494 (908) +|++..|.|.+| ++.|+++|++...+.+.+++ ++.++.++.|... T Consensus 283 ~l~~~~~~g~~g-~~~~~~~g~~~~~~~i~~~~----~~~~~~~~~~~~~ 327 (568) T 5ERE_A 283 WYAGNTFTGALG-KVTFANDGDASYPYIFKKVT----ESGFRVAEFQFPM 327 (568) T ss_dssp HHTTCEEEETTE-EEEECTTSBEECCEEEEEEE----TTEEEECTTHHHH T ss_pred HHhcCCcccccE-EEEECCCCCccccEEEEEEE----CCeEEEEEEEcch Confidence 888888999988 89999888887778888887 3578889988764 No 129 >3CKM_A Uncharacterized protein HI1655; YraM, periplasmic-binding protein, lipoprotein, unliganded; 1.35A {Haemophilus influenzae} SCOP: c.93.1.1 Probab=99.17 E-value=3.7e-15 Score=155.57 Aligned_cols=322 Identities=12% Similarity=0.097 Sum_probs=193.4 Template_Neff=11.900 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||+++|.++... ..+.....|++.|++ |+++++.+.|+.++ . ..+.++++ T Consensus 1 ~~i~ig~~~p~~~~~~----------~~~~~~~~g~~~a~~----------g~~i~~~~~d~~~~--~----~~~~~~~l 54 (327) T 3CKM_A 1 MVSQIGLLLPLSGDGQ----------ILGTTIQSGFNDAKG----------NSTIPVQVFDTSMN--S----VQDIIAQA 54 (327) T ss_pred CCeEEEEEecCCCCCh----------hHhHHHHHHHHHHHc----------CeeEEEEEEcCCcH--H----HHHHHHHH Confidence 3689999999876421 245677788888875 34577777776553 1 22333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANI-LRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~-~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) .. ++++++||+.++.....+... +...++|+|.+.+..+. ...++.+++.+++... T Consensus 55 ~~-------------------~~v~~iig~~~~~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~~~~~ 111 (327) T 3CKM_A 55 KQ-------------------AGIKTLVGPLLKQNLDVILADPAQIQGMDVLALNATPNS----RAIPQLCYYGLSPEDE 111 (327) T ss_pred HH-------------------cCCCEEEcCCCcHHHHhHHHHHHHHhCCCEEeCCCCCcc----cCCCCEEEecCCHHHH Confidence 32 478899998777666666665 78889999988765432 1246678888888888 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFA 282 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~ 282 (908) ++.+++++.+.+|+++++++.++.++....+.+++.+++. ++++.....+. . ..++...++++. .++|+|++.. T Consensus 112 ~~~~~~~l~~~~~~~v~vv~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~~~~~--~~~~~v~~~~ 185 (327) T 3CKM_A 112 AESAANKMWNDGVRNPLVAMPQNDLGQRVGNAFNVRWQQL-AGTDANIRYYN--L-PADVTYFVQENN--SNTTALYAVA 185 (327) T ss_pred HHHHHHHHHHcCCCEEEEEEcCCHHHHHHHHHHHHHHHHc-CCeEeEEeecC--C-CCCcHHHHHHHh--cCCCEEEEeC Confidence 8888998877899999999977778888888888888775 35554332222 1 124445555553 4789888777 Q NP_000836.2 283 NEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAP-VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAE 361 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~~~~~~i~~~~~~~~~~~-~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 361 (908) ....+..+++++++.+. +..+++.+.|...... .........+.+.... .+.. . ...+...+ T Consensus 186 ~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---------~~~~----~--~~~~~~~~ 248 (327) T 3CKM_A 186 SPTELAEMKGYLTNIVP--NLAIYASSRASASATNTNTDFIAQMNGVQFSDI---------PFFK----D--TNSPQYQK 248 (327) T ss_pred CHHHHHHHHHHHHHcCC--CCCEEeccCcCChhhhcHHhhhhhhccEEEEec---------CCCC----C--CCCHHHHH Confidence 65556777777776544 3456655433321110 0000111222221110 0000 0 00011111 Q NP_000836.2 362 FWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKE 441 (908) Q Consensus 362 ~~~~~~~~~~~~~~~~~~~~~~c~~~~~~~~~~~~~~~~~~~~~yDAv~~la~Al~~~~~~~~~~~~~~~~~~~~~~~~~ 441 (908) +.+.+... ..++.++..+||+++++++. +. T Consensus 249 -f~~~~~~~-------------------------~~~~~~~~~~yda~~~~~~~-~~----------------------- 278 (327) T 3CKM_A 249 -LAKSTGGE-------------------------YQLMRLYAMGADAWLLINQF-NE----------------------- 278 (327) T ss_pred -HHHHhCCC-------------------------CCCCHHHHHHHHHHHHHHHH-HH----------------------- Confidence 11111110 01234577899999998872 11 Q NP_000836.2 442 LLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTN 493 (908) Q Consensus 442 l~~~l~~~~f~G~~G~~v~Fd~~G~~~~~~~i~~~~~~~~~~~~~~Vg~~~~ 493 (908) .+.+++..|.|.+| ++.|+++|++...+.+.+++ ++.+..++.|.. T Consensus 279 -l~~~~~~~~~g~~g-~~~f~~~g~~~~~~~v~~~~----~g~~~~~~~~~~ 324 (327) T 3CKM_A 279 -LRQVPGYRLSGLTG-ILSADTNCNVERDMTWYQYQ----DGAIVPVVDHHH 324 (327) T ss_pred -HHHhcCCcccccce-eEEeCCCCCccCCEEEEEEE----CCEEEECCCccc Confidence 12233456888888 89999888776677777776 356777777654 No 130 >5VBG_A Penicillin-binding protein activator LpoA; Gram-negative bacteria, Outer membrane lipoprotein; HET: MSE; 2.8A {Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)} Probab=98.94 E-value=1.6e-13 Score=154.27 Aligned_cols=215 Identities=12% Similarity=0.095 Sum_probs=144.9 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.++... ..+.....|++.|++ |.++++.+.|+.++. .... T Consensus 219 ~~~~~~i~Ig~~~p~sg~~~----------~~~~~~~~g~~~a~~----------g~~i~~~~~d~~~~~------~~~~ 272 (543) T 5VBG_A 219 FQQTNVSQIGLLLPLSGDGQ----------ILGTTIQSGFNDAKG----------NSTIPVQVFDTSMNS------VQDI 272 (543) T ss_dssp CCCCCCCCEEEEECCSSTTH----------HHHHHHHHHHHHHHT----------TCCCCEEEEETTTSC------HHHH T ss_pred hccCCCcEEEEEecCCCCch----------HHHHHHHHHHHHHcc----------CCCCCEEEEeCCCCC------HHHH Confidence 45678899999999987531 345677788888873 345777777876542 1222 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVAN-ILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~-~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. +++++|||+.++.....++. ++...+||+|++.+..+. ..+++.+++.++ T Consensus 273 ~~~l~~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~ 329 (543) T 5VBG_A 273 IAQAKQ-------------------AGIKTLVGPLLKQNLDVILADPAQIQGMDVLALNATPNS----RAIPQLCYYGLS 329 (543) T ss_dssp HHHHHH-------------------TTCCEEECCCSHHHHHHHHHCGGGGTTCEEEESCCCTTC----CCCTTEEECCCC T ss_pred HHHHHH-------------------CCCCEEECCCCHHHHHHHHcCchhhcCCeEEEecCCCCc----ccCCCceEeeCC Confidence 233222 57899999877766655544 467899999988765543 124677888888 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ....+..+++++.+.+|++|++++.++.++....+.+++.+++. ++++.....+. . ..++...++++. .++|+| T Consensus 330 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~d~~~~~~~~~--~~~d~i 403 (543) T 5VBG_A 330 PEDEAESAANKMWNDGVRNPLVAMPQNDLGQRVGNAFNVRWQQL-AGTDANIRYYN--L-PADVTYFVQENN--SNTTAL 403 (543) T ss_dssp HHHHHHHHHHHHHHTTCCEEEEEEESSHHHHHHHHHHHHHHHHH-HSSCCEEEEES--S-TTHHHHHHHHHC--CTTEEE T ss_pred hHHHHHHHHHHHHHcCCCCcEEEcCCCHHHHHHHHHHHHHHHHh-hCCcCeeEEeC--C-ccchhHhhhccc--CCCCEE Confidence 88888888998887899999999977778877888888877765 45554332222 1 234445555553 378888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW 311 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~ 311 (908) ++.+.+..+..+++++++.+. ++.|++.+.| T Consensus 404 ~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~ 434 (543) T 5VBG_A 404 YAVASPTELAEMKGYLTNIVP--NLAIYASSRA 434 (543) T ss_dssp EECCCHHHHHHHHHHTTTTCT--TCEEEECGGG T ss_pred EEecCHHHHHHHHHHHhhccC--CCcEEEcchh Confidence 777666667777777776443 3456655433 No 131 >5KCN_A Penicillin-binding protein activator LpoA; Outer membrane lipoprotein, PBP1A, transpeptidase.; 1.965A {Haemophilus influenzae} Probab=98.94 E-value=1.6e-13 Score=154.22 Aligned_cols=215 Identities=12% Similarity=0.095 Sum_probs=144.4 Template_Neff=11.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++++||+++|.++... ..+.....|++.|++ |.++++.+.|+.++. .... T Consensus 219 ~~~~~~i~Ig~~~p~sg~~~----------~~~~~~~~g~~~a~~----------g~~i~~~~~d~~~~~------~~~~ 272 (543) T 5KCN_A 219 FQQTNVSQIGLLLPLSGDGQ----------ILGTTIQSGFNDAKG----------NSTIPVQVFDTSMNS------VQDI 272 (543) T ss_pred ccCCCCeEEEEEEeCCCCCh----------HHHHHHHHHHHHHHC----------CeeEEEEEEcCCCCH------HHHH Confidence 45678899999999986531 345677888888873 345777777776542 1222 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVAN-ILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~-~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. ++++++||+.++.....++. ++...+||+|++.+..+. ...++.+++.++ T Consensus 273 ~~~l~~-------------------~~v~~iig~~~s~~~~~~~~~~~~~~~ip~i~~~~~~~~----~~~~~~~~~~~~ 329 (543) T 5KCN_A 273 IAQAKQ-------------------AGIKTLVGPLLKQNLDVILADPAQIQGMDVLALNATPNS----RAIPQLCYYGLS 329 (543) T ss_pred HHHHHh-------------------CCCCEEECCCChHHHHHHHHHHHHHhCCCEEeCCCCCcc----cCCCCeeEecCC Confidence 233222 57899999887766655544 468899999988765542 124677888888 Q NP_000836.2 199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ....+..+++++.+.+|+++++++.++.++....+.+++.+++. ++++.....+. . ..++...++++. .++|+| T Consensus 330 ~~~~~~~~~~~~~~~~~~~v~il~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~--~-~~~~~~~~~~~~--~~~d~i 403 (543) T 5KCN_A 330 PEDEAESAANKMWNDGVRNPLVAMPQNDLGQRVGNAFNVRWQQL-AGTDANIRYYN--L-PADVTYFVQENN--SNTTAL 403 (543) T ss_pred HHHHHHHHHHHHHHcCCCEEEEEeCCCHHHHHHHHHHHHHHHHc-CCeEeEEEeCC--C-CCCcHHHHHHhh--cCCCEE Confidence 88888888988888899999999977778887888888877765 45554332232 1 224444555553 378888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW 311 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~~~ 311 (908) ++.+.+.....+++++++.+. ++.|++.+.| T Consensus 404 ~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~ 434 (543) T 5KCN_A 404 YAVASPTELAEMKGYLTNIVP--NLAIYASSRA 434 (543) T ss_pred EEcCCHHHHHHHHHHHHHhCC--CCCEEecccc Confidence 777666566777777775443 3455655433 No 132 >4PYR_A Putative branched-chain amino acid ABC; Structural Genomics, PSI-Biology, Midwest Center; HET: GSH; 1.45A {Chromobacterium violaceum} Probab=98.94 E-value=1.7e-13 Score=141.16 Aligned_cols=204 Identities=12% Similarity=0.096 Sum_probs=132.6 Template_Neff=11.700 Q NP_000836.2 45 DIILGGLFPVH-AKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 45 ~i~Ig~l~p~~-~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +++||++.|.+ +... ..+....+|+++|+++ | .++++.+.|+++ .. ..+.++++ T Consensus 1 ~i~ig~~~~~s~g~~~----------~~~~~~~~g~~~a~~~-n--------~~i~l~~~d~~~--~~----~~~~~~~l 55 (305) T 4PYR_A 1 KVRIGVILPAESSALG----------EAAAVVRSGVEAAAQV-D--------QSAELYSVDATG--DN----VVERYRAA 55 (305) T ss_dssp CEEEEEEECCTTSTTH----------HHHHHHHHHHHHHHHH-H--------CCEEEEEEECCG--GG----HHHHHHHH T ss_pred CeeEEEEecCCCccch----------HHHHHHHHHHHHHHhc-C--------CCCeEEEEeCCC--cc----HHHHHHHH Confidence 47899999988 6431 3567788999999998 6 246677777654 21 22233333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. ++++++||+.++.....++. ..++|+|.+.+..+. . ...++.+++.++...++ T Consensus 56 ~~-------------------~~v~~iig~~~s~~~~~~~~---~~~ip~i~~~~~~~~-~--~~~~~~~~~~~~~~~~~ 110 (305) T 4PYR_A 56 VA-------------------DGVNVVIGPLSRDSIVKLAP---SVTVPTLALNSVGRE-A--AANPKLYSLSLIVEGEA 110 (305) T ss_dssp HH-------------------TTCCEEECCCSHHHHHHHGG---GCCSCEEESSCCCTT-S--CCCTTEEECCCCHHHHH T ss_pred HH-------------------CCCCEEECCCCHHHHHHHhh---cCCCCEEEecCCChh-h--ccCCCeEEEecChHHHH Confidence 32 47889999877665544433 689999987765443 1 13567788888888888 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) ..+++++.+.+|+++++++.+++++....+.+++.+++. ++++.....+.. .++...+. + ..++|+|++... T Consensus 111 ~~~~~~~~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-g~~v~~~~~~~~----~d~~~~~~--~-~~~~d~v~~~~~ 182 (305) T 4PYR_A 111 RQLARLMRDDSRAAPLLVVGGDALSQRLGKAFADEWRAA-AGKPVRQMAFDA----NDMAPLLQ--A-AGQADAVALALD 182 (305) T ss_dssp HHHHHHHHHTTCSSEEEEECSSHHHHHHHHHHHHHHHHH-HSSCCEEEECCT----TCCHHHHH--H-HHTCSEEEEESC T ss_pred HHHHHHHHHCCCCceEEEEcCCHHHHHHHHHHHHHHHHC-CCcccEEEEeCh----hhhHHHHH--h-hcCCCEEEEeCC Confidence 899999887899999999977778888888888877765 455543322221 13333332 2 247898877765 Q NP_000836.2 284 EDDIRRILEAAKKLNQSGHFLWIGSDSW 311 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~~~~~~i~~~~~ 311 (908) .... .++.++.+. +..|++.+.| T Consensus 183 ~~~~-~~l~~~~~~----~~~~~~~~~~ 205 (305) T 4PYR_A 183 VAQA-ARLKSALTP----DVPVYGTSQL 205 (305) T ss_dssp HHHH-HHHHHHSCT----TSCEEECGGG T ss_pred HHHH-HHHHHHcCC----CCCEEeeccc Confidence 4444 555554431 2456665433 No 133 >4YLE_A Simple sugar transport system substrate-binding; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE; 1.7A {Burkholderia multivorans} Probab=97.77 E-value=1.5e-08 Score=103.45 Aligned_cols=224 Identities=12% Similarity=0.071 Sum_probs=130.6 Template_Neff=12.200 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. ..+.....+++.++++.|. ++++.+...|+..++ +...+. T Consensus 27 ~~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~a~~~~~~------~~~~~~~~~d~~~~~----~~~~~~ 84 (316) T 4YLE_A 27 AQAAGKPKVALVMKSLAN------------EFFLTMENGAKEYQKHNAS------QFDLITNGIKDETDT----ANQIRI 84 (316) T ss_dssp ---CCCCEEEEEEEETTS------------HHHHHHHHHHHHHHHHTTT------TCEEEEEEESSTTCH----HHHHHH T ss_pred hhhcCCCEEEEEecCCCC------------hHHHHHHHHHHHHHHhcCC------ccEEEEcccCCCCCH----HHHHHH Confidence 355678999999997542 2556778888888888653 233443333433332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. ++++++|+...+.... .....+...++|+|..+...+........++++++.++ T Consensus 85 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~v~~~ 145 (316) T 4YLE_A 85 VEQMIV-------------------SKVDAIVLAPADSKALVPVVKKAVDAGIIVVNIDNRLDPDVLKSKNLNVPFVGPD 145 (316) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCHHHHHTTTCCCCEEEEC T ss_pred HHHHHh-------------------cCCCEEEEcCCCccchHHHHHHHHHCCCEEEEEeCCCChHHHhhcCCCCcEeccC Confidence 444332 4788888754443322 44456677899999887654321111113567788888 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~ 273 (908) +...++.+++++.+. +.+++++++. ++.++..+.+++++.+++. ++.+....... .+..+....++++++ .. T Consensus 146 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 222 (316) T 4YLE_A 146 NRKGARKVGDYLAKKLKAGDQVGIVEGVSTTTNAQQRTAGFQDAMKAG-GMKVVSVQSGE--WEIDKGNAVASAMLNEYP 222 (316) T ss_dssp HHHHHHHHHHHHHHHSCTTCEEEEEESCTTSHHHHHHHHHHHHHHHHH-TCEEEEEEECT--TCHHHHHHHHHHHHHHCT T ss_pred hHHHHHHHHHHHHHHccCCCeEEEEEcCCCChhHHHHHHHHHHHHHhC-CCeEEEEeecC--CCHHHHHHHHHHHHHHCC Confidence 888888888887654 4678999885 4456677788888888775 35443221111 112233444555542 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|++.. +..+..+++++++.|+..++.+++. T Consensus 223 ~~~~i~~~~-~~~~~~~~~~l~~~g~~~~~~i~~~ 256 (316) T 4YLE_A 223 NLKALLCGN-DNMAIGAVSAVRAAGKQGKVYVVGY 256 (316) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHTTCTTTSEEECS T ss_pred CeeEEEECC-hHHHHHHHHHHHHcCCCCCeEEEEe Confidence 566776654 4456677888888776333444444 No 134 >4RK1_B Ribose transcriptional regulator; sugar binding, transcription regulation, Enzyme; HET: CL, MSE, RIB; 1.9A {Enterococcus faecium DO} Probab=97.68 E-value=2.9e-08 Score=99.18 Aligned_cols=204 Identities=13% Similarity=0.094 Sum_probs=120.4 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (280) T 4RK1_B 4 TKETKTIGVLVPDITN------------PFFSTLMRGIEDILYKQN----------FVTILCNADSDHQ----KEIEYLA 57 (280) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHGGGT----------CEEEEEECCC---------CCHHH T ss_pred ccCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHH Confidence 4567899999987542 245667788888877642 3344455443322 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++.. ++++++|+...+.........+...++|+|..+...+ .++.+++.+++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~~~~~ 111 (280) T 4RK1_B 58 ELTR-------------------RGVDGFIIATSAVSTDAINENLKKQGRPFIVLDQKKS-------EGFSDAVRTDDFR 111 (280) T ss_dssp HHHH-------------------TTCCEEEECCTTSCHHHCCCCCCTTTCCEEEETTSCC-------CTTCEEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCCCCChHHHHHHHHHcCCCEEEECCCCC-------CCCCceEEECcHH Confidence 3332 4788888755443333445566778999988765432 1356677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+++++++++. +..++..+.++|++.+++. ++.+..........+..+....++++++ .++|+|+ T Consensus 112 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 189 (280) T 4RK1_B 112 GGYLAGMHLLSLGHQTIALVYPENPPENVHARIEGFKSALDVY-QIPHDQLILLPTQFSKQGGYQITAELLD-SAATGVF 189 (280) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESSCCHHHHHHHHHHHHHHHHT-TCCGGGEEEEEECSSHHHHHHTHHHHHH-SCCCEEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCCCCChHHHHHHHHHHHHHHHc-CCCccceEEeCCCcccccHHHHHHHHhh-CCCCEEE Confidence 7888888887678889999985 3345666778888887764 3333211111100112234455566653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 190 ~~~-~~~~~~~~~~l~~~g~~ 209 (280) T 4RK1_B 190 ALN-DELAFGLYRGLEEAGKS 209 (280) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHcCCC Confidence 765 33467788888887764 No 135 >4RK1_D Ribose transcriptional regulator; sugar binding, transcription regulation, Enzyme; HET: RIB, CL; 1.9A {Enterococcus faecium DO} Probab=97.68 E-value=2.9e-08 Score=99.18 Aligned_cols=204 Identities=13% Similarity=0.094 Sum_probs=120.7 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (280) T 4RK1_D 4 TKETKTIGVLVPDITN------------PFFSTLMRGIEDILYKQN----------FVTILCNADSDHQ----KEIEYLA 57 (280) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT----------CEEEEEECCC--------CCCHHH T ss_pred ccCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHH Confidence 4567899999987542 245667788888877642 3344455443322 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++.. ++++++|+...+.........+...++|+|..+...+ .++.+++.+++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~~~~~ 111 (280) T 4RK1_D 58 ELTR-------------------RGVDGFIIATSAVSTDAINENLKKQGRPFIVLDQKKS-------EGFSDAVRTDDFR 111 (280) T ss_dssp HHHH-------------------TTCCEEEECCTTSCHHHCCCCCCTTTCCEEEETTSCC-------CTTCEEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCCCCChHHHHHHHHHcCCCEEEECCCCC-------CCCCceEEECcHH Confidence 3332 4788888755443333445566778999988765432 1356677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+++++++++. +..++..+.++|++.+++. ++.+..........+..+....++++++ .++|+|+ T Consensus 112 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 189 (280) T 4RK1_D 112 GGYLAGMHLLSLGHQTIALVYPENPPENVHARIEGFKSALDVY-QIPHDQLILLPTQFSKQGGYQITAELLD-SAATGVF 189 (280) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESSCCHHHHHHHHHHHHHHHHT-TCCGGGEEEEEECSSHHHHHHTHHHHHT-SCCSEEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCCCCChHHHHHHHHHHHHHHHc-CCCccceEEeCCCcccccHHHHHHHHhh-CCCCEEE Confidence 7888888887678889999985 3345666778888887764 3333211111100112234455566653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 190 ~~~-~~~~~~~~~~l~~~g~~ 209 (280) T 4RK1_D 190 ALN-DELAFGLYRGLEEAGKS 209 (280) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHcCCC Confidence 765 33467788888887764 No 136 >3BRQ_A HTH-type transcriptional regulator ascG; transcriptional repressor structure Escherichia coli; HET: MSE, SO4, FRU; 2.0A {Escherichia coli} Probab=97.64 E-value=3.8e-08 Score=99.33 Aligned_cols=208 Identities=10% Similarity=0.021 Sum_probs=121.6 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++. ...+.+ T Consensus 15 ~~~~~~~I~~i~~~~~~~----------~~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~ 70 (296) T 3BRQ_A 15 SAKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSAE----EERQAI 70 (296) T ss_dssp ----CCEEEEEECGGGCC------------CHHHHHHHHHHHHHHTT----------CEEEEECCTTSHH----HHHHHH T ss_pred ccCCCCEEEEEecCcccC----------CccHHHHHHHHHHHHHHcC----------CeEEEEeCCCCHH----HHHHHH Confidence 345689999999976421 1245567778877777642 3444555544422 233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++|+...+.....+...++..++|+|..+...+. +.++++..++. T Consensus 71 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~ 124 (296) T 3BRQ_A 71 QYLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHK 124 (296) T ss_dssp HHHHH-------------------TTCSEEEEECSSSCHHHHHHHHHTCSSCEEEESCCCSS-------SGGGEECCCHH T ss_pred HHHHh-------------------cCCCEEEEeCCCCChhhHHHHHHHcCCCEEEeCCCCCC-------CCCcEEEeCcH Confidence 44332 47888887655443334445566789999987764331 34566667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..++.+++++.+.++++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+....++++++. .++|+ T Consensus 125 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 203 (296) T 3BRQ_A 125 QTSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSA 203 (296) T ss_dssp HHHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHTT-TCCCCGGGEECCCSSHHHHHHHHHHHHTC--CCSE T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCChhHHHHHHHHHHHHHHC-CCCCCccceecCCCChhhHHHHHHHHHHcCCCCCE Confidence 77777788876668899999985433 5666778888888775 34433221111101122344455555431 23777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 204 v~~~~-~~~~~~~~~~~~~~g~~ 225 (296) T 3BRQ_A 204 LVASN-DDMAIGAMKALHERGVA 225 (296) T ss_dssp EEESS-HHHHHHHHHHHHHHTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888887764 No 137 >3BRQ_B HTH-type transcriptional regulator ascG; transcriptional repressor structure Escherichia coli; HET: SO4, FRU; 2.0A {Escherichia coli} Probab=97.64 E-value=3.8e-08 Score=99.33 Aligned_cols=208 Identities=10% Similarity=0.021 Sum_probs=122.3 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++. ...+.+ T Consensus 15 ~~~~~~~I~~i~~~~~~~----------~~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~ 70 (296) T 3BRQ_B 15 SAKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSAE----EERQAI 70 (296) T ss_dssp ----CCEEEEEEECCSCC----------SSCHHHHHHHHHHHHHHTT----------CEEEEEEEETSHH----HHHHHH T ss_pred ccCCCCEEEEEecCcccC----------CccHHHHHHHHHHHHHHcC----------CeEEEEeCCCCHH----HHHHHH Confidence 345689999999976421 1245567778877777642 3444555544422 233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++|+...+.....+...++..++|+|..+...+. +.++++..++. T Consensus 71 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~ 124 (296) T 3BRQ_B 71 QYLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHK 124 (296) T ss_dssp HHHHH-------------------TTCSEEEEECSSSCHHHHHHHHHTCSSCEEEESSCCSS-------CGGGEECBCHH T ss_pred HHHHh-------------------cCCCEEEEeCCCCChhhHHHHHHHcCCCEEEeCCCCCC-------CCCcEEEeCcH Confidence 44332 47888887655443334445566789999987764331 34566667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..++.+++++.+.++++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+....++++++. .++|+ T Consensus 125 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 203 (296) T 3BRQ_B 125 QTSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSA 203 (296) T ss_dssp HHHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHHHHCCCCSE T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCChhHHHHHHHHHHHHHHC-CCCCCccceecCCCChhhHHHHHHHHHHcCCCCCE Confidence 77777788876668899999985433 5666778888888775 34433221111101122344455555431 23777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 204 v~~~~-~~~~~~~~~~~~~~g~~ 225 (296) T 3BRQ_B 204 LVASN-DDMAIGAMKALHERGVA 225 (296) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888887764 No 138 >5DTE_B Monosaccharide-transporting ATPase (E.C.3.6.3.17); Solute Binding Protein, ENZYME FUNCTION; HET: ALL; 2.7A {Actinobacillus succinogenes (strain ATCC 55618 / 130Z)} Probab=97.59 E-value=5.2e-08 Score=99.26 Aligned_cols=222 Identities=16% Similarity=0.113 Sum_probs=126.5 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|..+. .++.....+++.++++. |+++.+...|+..++ +...+.+ T Consensus 22 ~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~v~~~~~~~~~~~----~~~~~~~ 77 (311) T 5DTE_B 22 SMADKPQIALLMKTLSN------------EYFISMRQGAEETAKQK--------DIDLIVQVAEKEDST----EQLVGLV 77 (311) T ss_dssp ---CCCEEEEEESCSSS------------HHHHHHHHHHHHHHHHT--------TCEECCEECSSTTCH----HHHHHHH T ss_pred ccCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHc--------CCEEEEEccCCCCcH----HHHHHHH Confidence 34468999999997542 25567788888888775 345655555543332 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++. ++++++|+...+... ......+.+.++|+|..+...+........++.+.+.+++ T Consensus 78 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~v~~d~ 138 (311) T 5DTE_B 78 ENMIA-------------------KKVDAIIVTPNDSIAFIPAFQKAEKAGIPIIDLDVRLDAKAAEAAGLKFNYVGVDN 138 (311) T ss_dssp HHHHH-------------------TTCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCCHHHHHHTTCCCEEEECCH T ss_pred HHHHh-------------------CCCCEEEECCCCccchHHHHHHHHHCCCCEEEEcCCCCHHHHHHhcCceEEEEeCh Confidence 43332 467877764433322 2444566778999998876543211100124567777888 Q NP_000836.2 200 SYQAQAMVDIVTAL-GW-NYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPN 274 (908) Q Consensus 200 ~~~~~~~~~~l~~~-~~-~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~ 274 (908) ...++.+++++.+. +. ++++++... ..++..+.++|++.+++.+++++....... .+..+....++++++ ..+ T Consensus 139 ~~~~~~~~~~l~~~~g~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~ 216 (311) T 5DTE_B 139 FNGGYLEAKNLAEAIGKKGNVAILEGIPGVDNGEQRKGGALKAFAEYPDIKIVASQSAN--WETEQALNVTTNILTANPN 216 (311) T ss_dssp HHHHHHHHHHHHHHTTSEEEEEEEECCSSCHHHHHHHHHHHHHHTTCTEEEEEEEEECT--TCHHHHHHHHHHHTTTSTT T ss_pred HHHHHHHHHHHHHHhCCCeEEEEEECCCCChhHHHHHHHHHHHHHhCCCeEEEEeccCC--CCHHHHHHHHHHHHHHCCC Confidence 77888888887654 76 889999743 235667788888887764223332211111 112234444555542 135 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|+|++.. +..+..+++++++.|+..++.+++. T Consensus 217 ~d~i~~~~-~~~a~~~~~~l~~~g~~~~i~vi~~ 249 (311) T 5DTE_B 217 INGIFAAN-DNMAIGAVTAVENAGLAGKVLVSGY 249 (311) T ss_dssp CCEEEESS-HHHHHHHHHHHHHTTCBTTBEEECC T ss_pred cCEEEECC-hhhHHHHHHHHHHCCCCCCeEEEEe Confidence 66676553 4456677888887776323344443 No 139 >3KSM_B ABC-type sugar transport system, periplasmic; ABC-type sugar transport system, periplasmic; HET: MSE, BDR; 1.9A {Hahella chejuensis} Probab=97.58 E-value=5.5e-08 Score=96.87 Aligned_cols=212 Identities=15% Similarity=0.056 Sum_probs=121.5 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++. |+++.+...|+..++. ...+.+++++. T Consensus 1 i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~~~~ 56 (276) T 3KSM_B 1 PKLLLVLKGDSN------------AYWRQVYLGAQKAADEA--------GVTLLHRSTKDDGDIA----GQIQILSYHLS 56 (276) T ss_dssp -CEEEECSCSSS------------THHHHHHHHHHHHHHHH--------TCCEEECCCSSTTCHH----HHHHHHHHHHH T ss_pred CeEEEEcCCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEecCCCCCCHH----HHHHHHHHHHH Confidence 478999887542 25567778888888775 3456555545433322 22333333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) .+++|++|+...+.... .....+...++|+|..+...+. .++++++.+++...++ T Consensus 57 ------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 112 (276) T 3KSM_B 57 ------------------QAPPDALILAPNSAEDLTPSVAQYRARNIPVLVVDSDLAG------DAHQGLVATDNYAAGQ 112 (276) T ss_dssp ------------------CCC-CEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCSS------SSSSEEEECCHHHHHH T ss_pred ------------------hCCCCEEEEcCCCHHhcHHHHHHHHHCCCCEEEEcCCCCC------CccceEEEcCHHHHHH Confidence 14788887654443322 3345567789999987654321 2456777777777777 Q NP_000836.2 205 AMVDIVTAL----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 205 ~~~~~l~~~----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .+++++.+. +.++++++.. ++.++..+.++|++.+++.+ ........+.. .+..+....+++++.. .++++ T Consensus 113 ~~~~~l~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 190 (276) T 3KSM_B 113 LAARALLATLDLSKERNIALLRLRAGNASTDQREQGFLDVLRKHD-KIRIIAAPYAG-DDRGAARSEMLRLLKETPTIDG 190 (276) T ss_dssp HHHHHHHHHSCTTSCEEEEECBCCTTCHHHHHHHHHHHHHHTTCT-TEEEEECCBCC-SCHHHHHHHHHHHHHHCSCCCE T ss_pred HHHHHHHHHcCcCCCceEEEEECCCCChhHHHHHHHHHHHHhhcC-CeEEEECCcCC-CCHHHHHHHHHHHHHHCCCCCE Confidence 888877554 7889999985 34556667788888877643 22111111110 1112333445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|+..++.+++. T Consensus 191 i~~~~-~~~~~~~~~~l~~~g~~~~~~i~~~ 220 (276) T 3KSM_B 191 LFTPN-ESTTIGALVAIRQSGMSKQFGFIGF 220 (276) T ss_dssp EECCS-HHHHHHHHHHHHHTTCTTSSEEEEE T ss_pred EEeCC-hHHHHHHHHHHHHcCCCCceEEEee Confidence 76654 4456678888888776433444443 No 140 >3KSM_A ABC-type sugar transport system, periplasmic; ABC-type sugar transport system, periplasmic; HET: BDR; 1.9A {Hahella chejuensis} Probab=97.58 E-value=5.5e-08 Score=96.87 Aligned_cols=212 Identities=15% Similarity=0.056 Sum_probs=122.8 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++. |+++.+...|+..++. ...+.+++++. T Consensus 1 i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~~~~ 56 (276) T 3KSM_A 1 PKLLLVLKGDSN------------AYWRQVYLGAQKAADEA--------GVTLLHRSTKDDGDIA----GQIQILSYHLS 56 (276) T ss_dssp CEEEEECSCSSS------------THHHHHHHHHHHHHHHH--------TCEEEECCCSSTTCHH----HHHHHHHHHHH T ss_pred CeEEEEcCCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEecCCCCCCHH----HHHHHHHHHHH Confidence 478999887542 25567778888888775 3456555545433322 22333333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) .+++|++|+...+.... .....+...++|+|..+...+. .++++++.+++...++ T Consensus 57 ------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 112 (276) T 3KSM_A 57 ------------------QAPPDALILAPNSAEDLTPSVAQYRARNIPVLVVDSDLAG------DAHQGLVATDNYAAGQ 112 (276) T ss_dssp ------------------HSCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCSSEEEECCHHHHHH T ss_pred ------------------hCCCCEEEEcCCCHHhcHHHHHHHHHCCCCEEEEcCCCCC------CccceEEEcCHHHHHH Confidence 14788887654443322 3345567789999987654321 2456777777777777 Q NP_000836.2 205 AMVDIVTAL----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 205 ~~~~~l~~~----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .+++++.+. +.++++++.. ++.++..+.++|++.+++.+ ........+.. .+..+....+++++.. .++++ T Consensus 113 ~~~~~l~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 190 (276) T 3KSM_A 113 LAARALLATLDLSKERNIALLRLRAGNASTDQREQGFLDVLRKHD-KIRIIAAPYAG-DDRGAARSEMLRLLKETPTIDG 190 (276) T ss_dssp HHHHHHHHHSCTTSCEEEEECBCCTTCHHHHHHHHHHHHHHTTCT-TEEEEECCBCC-SSHHHHHHHHHHHHHHCSCCCE T ss_pred HHHHHHHHHcCcCCCceEEEEECCCCChhHHHHHHHHHHHHhhcC-CeEEEECCcCC-CCHHHHHHHHHHHHHHCCCCCE Confidence 888877554 7889999985 34556667788888877643 22111111110 1112333445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|+..++.+++. T Consensus 191 i~~~~-~~~~~~~~~~l~~~g~~~~~~i~~~ 220 (276) T 3KSM_A 191 LFTPN-ESTTIGALVAIRQSGMSKQFGFIGF 220 (276) T ss_dssp EECCS-HHHHHHHHHHHHHTTCTTSSEEEEE T ss_pred EEeCC-hHHHHHHHHHHHHcCCCCceEEEee Confidence 76654 4456678888888776433444443 No 141 >4RSM_A Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: 3VB; 1.6A {Mycobacterium smegmatis} Probab=97.58 E-value=5.6e-08 Score=99.91 Aligned_cols=213 Identities=12% Similarity=0.053 Sum_probs=123.2 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...+++++||++.|.++ .++.....+++.++++.| +++.+.|...+. ....+. T Consensus 7 ~~~~~~~~Ig~i~~~~~-------------~~~~~~~~g~~~~~~~~~----------~~l~~~~~~~~~----~~~~~~ 59 (327) T 4RSM_A 7 AANSDTTRIGVTVYDMS-------------SFITAGKEGMDAYAKDNN----------IELIWNSANLDV----STQASQ 59 (327) T ss_dssp ----CCEEEEEEESCCC-------------HHHHHHHHHHHHHHHHHT----------EEEEEEECTTCH----HHHHHH T ss_pred cccCCCeEEEEEECCcc-------------HHHHHHHHHHHHHHHhCC----------CEEEEecCCCCH----HHHHHH Confidence 45677899999998753 245667778888887653 344455544332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+. .++.+++.++ T Consensus 60 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 114 (327) T 4RSM_A 60 VDSMIN-------------------QGVDAIIVVPVQADSLAPQVASAKAKGIPLVPVNAALDS------KDIAGNVQPD 114 (327) T ss_dssp HHHHHH-------------------TTCSEEEEECSCSSCCHHHHHHHHHTTCCEEEBSSCCSC------SCSSCCBEEC T ss_pred HHHHHH-------------------cCCCEEEEeCCCccchHHHHHHHHHCCCCEEEECCCCCc------cCCceEEcCC Confidence 443332 46787775433322 224445566789999987764331 2456777788 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...+..+++++.+. +.++|+++.. ++.++..+.+++.+.+++.+++.+....... .+..+....+++++.. T Consensus 115 ~~~~~~~~~~~l~~~~~~~~~i~~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 192 (327) T 4RSM_A 115 DVAAGAQEMQMMADRLGGKGNIVILQGPLGQSGELDRSKGIEQVLAKYPDIKVLAKDTAN--WKRDEAVNKMKNWISGFG 192 (327) T ss_dssp HHHHHHHHHHHHHHHHTTCEEEEEEECSTTSHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred HHHHHHHHHHHHHHHhCCCcEEEEEECCCCChhHHHHHHHHHHHHHhCCCeEEEEEecCC--CCHHHHHHHHHHHHHhhc Confidence 777788888887654 6789999985 4445667778888877664223332211111 1112334445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++|+|++.. +..+..+++++++.|.. ++.+++. T Consensus 193 ~~~d~i~~~~-~~~a~~~~~al~~~g~~-~~~iig~ 226 (327) T 4RSM_A 193 PQIDGVVAQN-DDMGLGALQALKESGRT-GVPIVGI 226 (327) T ss_dssp GGCCEEEESS-HHHHHHHHHHHHHTTCC-CCCEECS T ss_pred CCCCEEEECC-hHHHHHHHHHHHHcCCC-CCCEEEe Confidence 3577777664 33566778888877763 2344444 No 142 >6HBD_B ABC transporter periplasmic-binding protein YtfQ; periplasmic binding protein, SUGAR BINDING; HET: GZL, ZN; 2.44A {Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)} Probab=97.57 E-value=5.7e-08 Score=99.43 Aligned_cols=211 Identities=12% Similarity=0.056 Sum_probs=122.7 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ...+ T Consensus 11 ~~~~~~~~~Igvi~~~~~~------------~~~~~~~~g~~~a~~~~~----------~~l~~~~~~~~~~----~~~~ 64 (320) T 6HBD_B 11 GSAPDGALTLGFAQVGAES------------GWRTANTESIKSAAEEAG----------VNLKFADANGEQE----KQIS 64 (320) T ss_dssp -----CCEEEEEECCCCCS------------HHHHHHHHHHHHHHHHHT----------EEEEEECCTTCHH----HHHH T ss_pred CCCCCCCcEEEEEecCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEECCCCCHH----HHHH Confidence 4566788999999987542 255667788888887653 3444555543322 2233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|....+. ........+...++|+|..+...+... ..++++++.+ T Consensus 65 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~ 122 (320) T 6HBD_B 65 AIRSFIQ-------------------QGVDVIAFSPVVRTGWDAVLQETKNAGIPVILTDRAVDTQD---TDVYKTFIGA 122 (320) T ss_dssp HHHHHHH-------------------HTCSEEEECCSSSSSCHHHHHHHHHHTCCEEEESCCCCCSS---SSSCSEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCCccCHHHHHHHHHHCCCCEEEeCCCCCCCC---CcchheEecC Confidence 3443332 4677766543332 223445566678999998776543211 1355677888 Q NP_000836.2 198 PDSYQAQAMVDIVTA-----LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL 270 (908) Q Consensus 198 ~~~~~~~~~~~~l~~-----~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~ 270 (908) ++...+..+++++.+ .+.++++++.. +..++..+.++|++.+++.+++.+....... .+..+....+++++ T Consensus 123 d~~~~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~ 200 (320) T 6HBD_B 123 DFIEEGRRAGQWVADQYASATGPVNIVQLEGTTGADPAIDRKTGFAEGISKNPNLKIVASQTGD--FTRSGGKQVMEAFL 200 (320) T ss_dssp CHHHHHHHHHHHHHHHSSSCSSCEEEEEEECSTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TSHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHhcCCCceEEEEEcCCCChHHHHHHHHHHHHHhhCCCeEEEEeecCC--CCHHHHHHHHHHHH Confidence 877777788877754 47789999985 3456667778888887764224443221111 11223444555554 Q NP_000836.2 271 E-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 271 ~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) + ..++|+|++.. +..+..+++++++.|+. T Consensus 201 ~~~~~~d~i~~~~-~~~a~~~~~~l~~~g~~ 230 (320) T 6HBD_B 201 KSTPQIDVVFAQN-DDMGLGAMEAIEAAGKK 230 (320) T ss_dssp HHCSCCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHCCCCCEEEECC-HHHHHHHHHHHHHcCCC Confidence 2 13567776654 34556788888887764 No 143 >4JOQ_A ABC ribose transporter, periplasmic solute-binding; structural genomics, ribose, ABC transporter; 1.9A {Rhodobacter sphaeroides} Probab=97.56 E-value=6.4e-08 Score=97.68 Aligned_cols=218 Identities=11% Similarity=0.018 Sum_probs=129.3 Template_Neff=12.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.+++++|+.+ ..+++.+.++ .++ ....+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~~~~-----~~~~~~~~~~-~~~----~~~~~~~~ 61 (297) T 4JOQ_A 4 QEKVGTIGIAIPSATH------------GFMGGLNFHAQDTIKRLQEVY-----PQLDFVLATA-GNA----GKMVNDIE 61 (297) T ss_dssp CCCCEEEEEEEECCSS------------HHHHHHHHHHHHHHHHHHHHC-----TTEEEEEEEE-SSH----HHHHHHHH T ss_pred cccceEEEEEeccCCC------------hhHHHHHHHHHHHHHHHHHHc-----ccccEEEEcC-CCH----HHHHHHHH Confidence 4578999999997642 256677889999999988643 1344444444 222 12223334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .++++++|+...+.... .....+...++|+|..+...+. ..++.+++.+++. T Consensus 62 ~l~~------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d~~ 118 (297) T 4JOQ_A 62 DMVA------------------TRNISALVVLPFESEPLTSPVQAVKEAGIWVTVVDRGLSV-----EGIEDLYVAGDNP 118 (297) T ss_dssp HHHH------------------HHCCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCSS-----SSCCSEEEEECHH T ss_pred HHHH------------------hCCCCEEEEcCCCCCCCcHHHHHHHHcCCEEEEEeCCCCC-----CCceeEEEEcCch Confidence 3332 14788888765444322 3445566789999987764431 1345677778887 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..++.+++++.+. +.++++++..+ ..++..+.+++++.+++. ++++....... .+..+....++++++. .+++ T Consensus 119 ~~~~~~~~~l~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (297) T 4JOQ_A 119 GFGRVAGEYFAQHLESGKKIVVLRGIPTTLDNERVEAFTAAIEGS-GIEVLDMQHGN--WNRDDAFNVMQDFLSKYPQID 195 (297) T ss_dssp HHHHHHHHHHHHHCCTTCEEEEEECSSSHHHHHHHHHHHHHTTTS-CCEEEEEEECT--TCHHHHHHHHHHHHHHCSCCC T ss_pred HHHHHHHHHHHHHccCCCEEEEEECCCCChHHHHHHHHHHHHhcC-CcEEeecccCC--CCHHHHHHHHHHHHHhCCCCC Confidence 7788888887554 67889988844 345566777888877765 35443221111 1122344455555421 2366 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~a~~~~~~l~~~g~~~~~~v~g~ 226 (297) T 4JOQ_A 196 AVWAAD-DDMAIGAMEAIAQAGRTEEMWVMGG 226 (297) T ss_dssp EEECCS-HHHHHHHHHHHHHTTCGGGCEEECC T ss_pred EEEECC-hHHHHHHHHHHHHCCCCCCcEEEec Confidence 666553 4446677788887776323444443 No 144 >4JOQ_B ABC ribose transporter, periplasmic solute-binding; structural genomics, ribose, ABC transporter; HET: MSE; 1.9A {Rhodobacter sphaeroides} Probab=97.56 E-value=6.4e-08 Score=97.68 Aligned_cols=218 Identities=11% Similarity=0.018 Sum_probs=129.3 Template_Neff=12.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.+++++|+.+ ..+++.+.++ .++ ....+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~~~~-----~~~~~~~~~~-~~~----~~~~~~~~ 61 (297) T 4JOQ_B 4 QEKVGTIGIAIPSATH------------GFMGGLNFHAQDTIKRLQEVY-----PQLDFVLATA-GNA----GKMVNDIE 61 (297) T ss_dssp CCCCEEEEEEEECCSS------------HHHHHHHHHHHHHHHHHHHHC-----TTEEEEEEEE-SSH----HHHHHHHH T ss_pred cccceEEEEEeccCCC------------hhHHHHHHHHHHHHHHHHHHc-----ccccEEEEcC-CCH----HHHHHHHH Confidence 4578999999997642 256677889999999988643 1344444444 222 12223334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .++++++|+...+.... .....+...++|+|..+...+. ..++.+++.+++. T Consensus 62 ~l~~------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d~~ 118 (297) T 4JOQ_B 62 DMVA------------------TRNISALVVLPFESEPLTSPVQAVKEAGIWVTVVDRGLSV-----EGIEDLYVAGDNP 118 (297) T ss_dssp HHHH------------------HHCCSEEEECCSSHHHHHHHHHHHHHTTCEEEEESSCCSS-----TTCCSEEEEECHH T ss_pred HHHH------------------hCCCCEEEEcCCCCCCCcHHHHHHHHcCCEEEEEeCCCCC-----CCceeEEEEcCch Confidence 3332 14788888765444322 3445566789999987764431 1345677778887 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..++.+++++.+. +.++++++..+ ..++..+.+++++.+++. ++++....... .+..+....++++++. .+++ T Consensus 119 ~~~~~~~~~l~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (297) T 4JOQ_B 119 GFGRVAGEYFAQHLESGKKIVVLRGIPTTLDNERVEAFTAAIEGS-GIEVLDMQHGN--WNRDDAFNVMQDFLSKYPQID 195 (297) T ss_dssp HHHHHHHHHHHHHCCTTCEEEEEECSSSHHHHHHHHHHHHHHTTS-CCEEEEEEECT--TCHHHHHHHHHHHHHHCSCCC T ss_pred HHHHHHHHHHHHHccCCCEEEEEECCCCChHHHHHHHHHHHHhcC-CcEEeecccCC--CCHHHHHHHHHHHHHhCCCCC Confidence 7788888887554 67889988844 345566777888877765 35443221111 1122344455555421 2366 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~a~~~~~~l~~~g~~~~~~v~g~ 226 (297) T 4JOQ_B 196 AVWAAD-DDMAIGAMEAIAQAGRTEEMWVMGG 226 (297) T ss_dssp EEECCS-HHHHHHHHHHHHHTTCGGGCEEECC T ss_pred EEEECC-hHHHHHHHHHHHHCCCCCCcEEEec Confidence 666553 4446677788887776323444443 No 145 >5HSG_A Putative ABC transporter, nucleotide binding/ATPase; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE; 1.3A {Klebsiella pneumoniae subsp. pneumoniae} Probab=97.54 E-value=7e-08 Score=98.22 Aligned_cols=214 Identities=10% Similarity=0.040 Sum_probs=121.8 Template_Neff=11.600 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ...+.+ T Consensus 21 ~~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~ 74 (310) T 5HSG_A 21 QSMAGPTYALVQINQQA------------LFFNLMNKGAQDAAKASG----------KDLVIFNSNDNPV----AQNDAI 74 (310) T ss_dssp ----CCSEEEEESCSSS------------HHHHHHHHHHHHHHHHTT----------CCEEEEECTTCHH----HHHHHH T ss_pred ccCCCCEEEEEEecCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHH Confidence 44578999999997642 255677788888887653 3344455443322 223344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++. .+++++|+...+... ......+...++|+|..+...+. .+..+++.+++ T Consensus 75 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~ 129 (310) T 5HSG_A 75 ENYIQ-------------------QGVKGILVAAIDVNGIMPAVKEAAAANIPVIAIDAVLPA------GPQAAQVGVDN 129 (310) T ss_dssp HHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCS------SSCSEEEECCH T ss_pred HHHHH-------------------cCCCEEEEeCCCccccHHHHHHHHHCCCCEEEEccCCCC------CCcceEEEcCh Confidence 44332 477877765443322 23445566789999987654331 24566777777 Q NP_000836.2 200 SYQAQAMVDIVTAL------GWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~------~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ...++.+++++.+. +.++++++.. ++.++..+.++|++.+++.+...+....... .+..+....+++++. T Consensus 130 ~~~~~~~~~~l~~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~ 207 (310) T 5HSG_A 130 IEGGRIIGQYFVDYVQKEMGGQARLGIVGALNSAIQNQRQKGFEETLKSNPKITIANVVDGQ--NVQDKAMTAAENLITG 207 (310) T ss_dssp HHHHHHHHHHHHHHHHHHSTTCEEEEEEECTTCHHHHHHHHHHHHHHTTCTTEEEC-CEECT--TCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCCceEEEEEecCCcHHHHHHHHHHHHHHHhCCCcEEeEeecCC--CCHHHHHHHHHHHHhh Confidence 77777777776544 7789999875 4455667778888887764213332211111 111233445555542 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ..++++|++.. +..+..+++++++.|...++.+++. T Consensus 208 ~~~~~~i~~~~-~~~a~~~~~~~~~~g~~~~i~v~~~ 243 (310) T 5HSG_A 208 NPDLTAIYATG-EPALLGAIAAVENQGRQKDIKVFGW 243 (310) T ss_dssp CTTCCEEEESS-HHHHHHHHHHHHHTTCTTTCEEEEE T ss_pred CCCcCEEEEcC-chHHHHHHHHHHHCCCCCCeEEEEe Confidence 12466666553 4456678888887776323444443 No 146 >2O20_B Catabolite control protein A; ccpa, transcriptional regulator, helix-turn-helix, TRANSCRIPTION; HET: SO4; 1.9A {Lactococcus lactis} Probab=97.51 E-value=8.3e-08 Score=98.76 Aligned_cols=203 Identities=9% Similarity=0.059 Sum_probs=122.1 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ +++.+.|...++ +...+.++ T Consensus 60 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (332) T 2O20_B 60 SKRTTTVGVILPTITS------------TYFAAITRGVDDIASMYK----------YNMILANSDNDV----EKEEKVLE 113 (332) T ss_dssp ---CCEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred hCCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHH Confidence 3568899999987542 255677788888777642 234444544332 22333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ++++++|+...+... .....+...++|+|..+...+ .++.+.+..++.. T Consensus 114 ~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 166 (332) T 2O20_B 114 TFLS-------------------KQVDGIVYMGSSLDE-KIRTSLKNSRTPVVLVGTIDG-------DKEIPSVNIDYHL 166 (332) T ss_dssp HHHH-------------------TTCSEEEEESSSCCH-HHHHHHHHHTCCEEEESCCCT-------TSCSCEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEeCHHH Confidence 3332 478888875544332 444556778999998765432 2345666777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+.++++++.. ++.++..+.++|++.+++. ++.+..........+..+....+++++. .++|+|+ T Consensus 167 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 244 (332) T 2O20_B 167 AAYQSTKKLIDSGNKKIAYIMGSLKDVENTERMVGYQEALLEA-NIEFDENLVFEGNYSYEQGKALAERLLE-RGATSAV 244 (332) T ss_dssp HHHHHHHHHHHTTCSSEEEECSCTTSHHHHHHHHHHHHHHHHH-TCCCCGGGEECSCCSHHHHHHHHHHHHH-TTCCEEE T ss_pred HHHHHHHHHHHcCCCcEEEEeCCCCcHHHHHHHHHHHHHHHHC-CCCCCHHHeeccCCCHHHHHHHHHHHHH-cCCCEEE Confidence 7778888876668889999985 3345667788888888765 3443321111101112234455666653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 245 ~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 2O20_B 245 VSH-DTVAVGLLSAMMDKGVK 264 (332) T ss_dssp ESC-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHCCCC Confidence 654 44566778888887764 No 147 >2O20_F Catabolite control protein A; ccpa, transcriptional regulator, helix-turn-helix, TRANSCRIPTION; HET: SO4; 1.9A {Lactococcus lactis} Probab=97.51 E-value=8.3e-08 Score=98.76 Aligned_cols=203 Identities=9% Similarity=0.059 Sum_probs=123.3 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ +++.+.|...++ +...+.++ T Consensus 60 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (332) T 2O20_F 60 SKRTTTVGVILPTITS------------TYFAAITRGVDDIASMYK----------YNMILANSDNDV----EKEEKVLE 113 (332) T ss_dssp -CCCCEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred hCCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHH Confidence 3568899999987542 255677788888777642 234444544332 22333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ++++++|+...+... .....+...++|+|..+...+ .++.+.+..++.. T Consensus 114 ~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 166 (332) T 2O20_F 114 TFLS-------------------KQVDGIVYMGSSLDE-KIRTSLKNSRTPVVLVGTIDG-------DKEIPSVNIDYHL 166 (332) T ss_dssp HHHH-------------------TTCSEEEECSSCCCH-HHHHHHHHHTCCEEEESCCCT-------TSCSCEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEeCHHH Confidence 3332 478888875544332 444556778999998765432 2345666777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+.++++++.. ++.++..+.++|++.+++. ++.+..........+..+....+++++. .++|+|+ T Consensus 167 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~ 244 (332) T 2O20_F 167 AAYQSTKKLIDSGNKKIAYIMGSLKDVENTERMVGYQEALLEA-NIEFDENLVFEGNYSYEQGKALAERLLE-RGATSAV 244 (332) T ss_dssp HHHHHHHHHHHTTCSSEEEECSCTTSHHHHHHHHHHHHHHHHT-TCCCCGGGEECSCCSHHHHHHHHHHHHH-TTCCEEE T ss_pred HHHHHHHHHHHcCCCcEEEEeCCCCcHHHHHHHHHHHHHHHHC-CCCCCHHHeeccCCCHHHHHHHHHHHHH-cCCCEEE Confidence 7778888876668889999985 3345667788888888765 3443321111101112234455666653 4788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 245 ~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 2O20_F 245 VSH-DTVAVGLLSAMMDKGVK 264 (332) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-hHHHHHHHHHHHHCCCC Confidence 654 44566778888887764 No 148 >4YO7_A Sugar ABC transporter (Sugar-binding protein); ENZYME FUNCTION INITIATIVE, EFI, Structural; HET: INS, MSE; 1.7A {Bacillus halodurans} Probab=97.51 E-value=8.5e-08 Score=98.37 Aligned_cols=216 Identities=14% Similarity=0.082 Sum_probs=126.6 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. ++....++++.++++.| + +++.+.|+..++. ...+. T Consensus 40 ~~~~~~~~Igv~~~~~~~-------------~~~~~~~~~~~~~~~~~-------~--~~~~~~~~~~~~~----~~~~~ 93 (326) T 4YO7_A 40 TGDSGQKVIGVSISNLDE-------------FLTYMQDAMKEEAANYP-------D--FEFIFSDAQNDST----QQMAQ 93 (326) T ss_dssp CCCCCCEEEEEEESCCCH-------------HHHHHHHHHHHHHTTCT-------T--EEEEEEECTTCHH----HHHHH T ss_pred cccCCCeEEEEEECCccH-------------HHHHHHHHHHHHHHhCC-------C--CEEEEecCCCCHH----HHHHH Confidence 456788999999987632 45567778888777754 2 3445555544422 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+... ......+...++|+|..+...+. ..++++++.++ T Consensus 94 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d 149 (326) T 4YO7_A 94 VENFIS-------------------RNVDAIIVNPVDTTSAVDIVNMVNDAGIPIIIANRTFDG-----VDQATAFVGSE 149 (326) T ss_dssp HHHHHH-------------------HTCSEEEECCSCHHHHHHHHHHHHHHTCCEEEESCCCTT-----GGGSSEEEECC T ss_pred HHHHHh-------------------CCCCEEEEcCCCcchhHHHHHHHHHCCCCEEEEccCCCC-----CccccEEEccc Confidence 443332 467877765443332 24445566789999987654331 13456777777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~ 273 (908) +...++.+++++.+ .+.++++++..+ ..++..+.+++++.+++.+++++....... .+..+....++++++ .. T Consensus 150 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 227 (326) T 4YO7_A 150 SIQSGLLQMEEVAKLLNNEGNIAIMDGELGHEAQIMRTEGNKQIIEEHDGLEVVLQGTAK--FDRSEGMRLMENWLNSGT 227 (326) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEEECSTTCHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHHHTTC T ss_pred hHHHHHHHHHHHHHHhCCCceEEEEECCCCCHHHHHHHHHHHHHHHhCCCeeEEEeccCC--CCHHHHHHHHHHHHHhCC Confidence 77777788887755 467899999853 235667777888877654223433211111 111233444555542 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|+|+... +..+..+++++++.|...++.+++. T Consensus 228 ~~d~i~~~~-~~~~~~~~~~l~~~g~~~~i~iv~~ 261 (326) T 4YO7_A 228 EIDAVVANN-DEMALGAILALEAVGKLDDVIVAGI 261 (326) T ss_dssp CCSEEEESS-HHHHHHHHHHHHHTTCGGGSEEECS T ss_pred CCCEEEECC-hHHHHHHHHHHHHCCCCCCeEEEEe Confidence 577776654 4456678888888776323444444 No 149 >6GQ0_A Putative sugar binding protein; Glucose-galactose binding protein, Gebacillus stearothermophilus; 1.94A {Geobacillus stearothermophilus} Probab=97.49 E-value=9.5e-08 Score=97.65 Aligned_cols=220 Identities=12% Similarity=0.077 Sum_probs=123.4 Template_Neff=11.400 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALE 114 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~ 114 (908) .........++++||++.|..+. .++.....+++.++++.+ +++.+...+. .++ + T Consensus 20 ~~~~~~~~~~~~~I~vv~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~ 74 (318) T 6GQ0_A 20 KERVPETTKEAYHFVLVPEELDN------------DYWRLVEKGAKAAAKELG--------VDLEYIGPRQ-ANI----D 74 (318) T ss_dssp --------CCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHHT--------CEEEECCCSS-CCH----H T ss_pred ccCCCCCCCCcEEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CEEEEECCCc-cCH----H Confidence 33444567788999999885432 245677788888887753 3444443322 221 1 Q NP_000836.2 115 QSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFS 193 (908) Q Consensus 115 ~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~ 193 (908) ...+.+++++. ++++++|+...+.... .....+...++|+|..+...+. .++++ T Consensus 75 ~~~~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~ 129 (318) T 6GQ0_A 75 EHLRILKKAAA-------------------AKVDGIITQGLTEAEFVPVINEITDKNIPVVTIDTDAPT------SRRVA 129 (318) T ss_dssp HHHHHHHHHHH-------------------TTCSEEEECCCBHHHHHHHHHHHHTTTCCEEEESSCCTT------SCCSE T ss_pred HHHHHHHHHHH-------------------CCCCEEEECCCCHHHhHHHHHHHHHCCCCEEEEeCCCCc------ccceE Confidence 22333443332 4788887654433221 3344566679999987654321 24567 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTA--LGWNYVSTLASEGN--YGESGVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~--~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) ++.+++...+..+++++.+ .+.++++++..+.. ++..+.+++++.+++ . ++.+....... .+..+....+.+ T Consensus 130 ~v~~~~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~ 206 (318) T 6GQ0_A 130 YVGTDNYYAGFLAGRALAEDTKGKATVAIITGSLTAAHQQLRVRGFEDAVRQEK-GIRIVAIEESH--ITRVQAAEKAYT 206 (318) T ss_dssp EEEECHHHHHHHHHHHHHHHTTTCEEEEEEESCSSBHHHHHHHHHHHHHHTTCT-TEEEEEEEECT--TCHHHHHHHHHH T ss_pred EEEcChHHHHHHHHHHHHHHcCCCcEEEEEECCCCcHHHHHHHHHHHHHHHhcC-CeEEEEEEecC--CCHHHHHHHHHH Confidence 7777777778888888765 57889999985433 455677777777765 3 34443211111 111223344455 Q NP_000836.2 269 LLET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 269 l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++. .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 207 ~l~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~i~i~~~ 246 (318) T 6GQ0_A 207 ILKKHPDVNAFYGTS-ALDAIGVAKVVEQFHREQKTYIIGF 246 (318) T ss_dssp HHHHCTTCCEEEECS-TTHHHHHHHHHHHTTCGGGCEEEEE T ss_pred HHHHCCCcCEEEEcC-cchHHHHHHHHHHcCCCCCeEEEEe Confidence 5421 2678876665 3556678888887776323444443 No 150 >6GT9_C Putative sugar binding protein; Glucose-galactose binding protein, Geobacillus stearothermophilus; HET: SO4, GAL; 1.894A {Geobacillus stearothermophilus} Probab=97.49 E-value=9.5e-08 Score=97.65 Aligned_cols=220 Identities=12% Similarity=0.077 Sum_probs=125.3 Template_Neff=11.400 Q NP_000836.2 35 EYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALE 114 (908) Q Consensus 35 ~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~ 114 (908) .........++++||++.|..+. .++.....+++.++++.+ +++.+...+. .++ + T Consensus 20 ~~~~~~~~~~~~~I~vv~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~ 74 (318) T 6GT9_C 20 KERVPETTKEAYHFVLVPEELDN------------DYWRLVEKGAKAAAKELG--------VDLEYIGPRQ-ANI----D 74 (318) T ss_dssp -----CCSTTSCEEEEECSSTTC------------HHHHHHHHHHHHHHHHHT--------CEEEECCCSS-CCH----H T ss_pred ccCCCCCCCCcEEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CEEEEECCCc-cCH----H Confidence 33444567788999999885432 245677788888887753 3444443322 221 1 Q NP_000836.2 115 QSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFS 193 (908) Q Consensus 115 ~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~ 193 (908) ...+.+++++. ++++++|+...+.... .....+...++|+|..+...+. .++++ T Consensus 75 ~~~~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~ 129 (318) T 6GT9_C 75 EHLRILKKAAA-------------------AKVDGIITQGLTEAEFVPVINEITDKNIPVVTIDTDAPT------SRRVA 129 (318) T ss_dssp HHHHHHHHHHH-------------------TTCSEEEECCCCHHHHHHHHHHHHHTTCCEEEESSCCTT------SCCSE T ss_pred HHHHHHHHHHH-------------------CCCCEEEECCCCHHHhHHHHHHHHHCCCCEEEEeCCCCc------ccceE Confidence 22333443332 4788887654433221 3344566679999987654321 24567 Q NP_000836.2 194 RVVPPDSYQAQAMVDIVTA--LGWNYVSTLASEGN--YGESGVEAFTQISRE-IGGVCIAQSQKIPREPRPGEFEKIIKR 268 (908) Q Consensus 194 ~~~~~~~~~~~~~~~~l~~--~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~-~~~i~v~~~~~~~~~~~~~~~~~~~~~ 268 (908) ++.+++...+..+++++.+ .+.++++++..+.. ++..+.+++++.+++ . ++.+....... .+..+....+.+ T Consensus 130 ~v~~~~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~ 206 (318) T 6GT9_C 130 YVGTDNYYAGFLAGRALAEDTKGKATVAIITGSLTAAHQQLRVRGFEDAVRQEK-GIRIVAIEESH--ITRVQAAEKAYT 206 (318) T ss_dssp EEECCHHHHHHHHHHHHHHHTTTEEEEEEEESCSSCHHHHHHHHHHHHHHTTCT-EEEEEEEEECT--TCHHHHHHHHHH T ss_pred EEEcChHHHHHHHHHHHHHHcCCCcEEEEEECCCCcHHHHHHHHHHHHHHHhcC-CeEEEEEEecC--CCHHHHHHHHHH Confidence 7777777778888888765 57889999985433 455677777777765 3 34443211111 111223344455 Q NP_000836.2 269 LLET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 269 l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++. .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 207 ~l~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~i~i~~~ 246 (318) T 6GT9_C 207 ILKKHPDVNAFYGTS-ALDAIGVAKVVEQFHREQKTYIIGF 246 (318) T ss_dssp HHHHCTTCCEEEECS-TTHHHHHHHHHHHHCCSSCCEEEEE T ss_pred HHHHCCCcCEEEEcC-cchHHHHHHHHHHcCCCCCeEEEEe Confidence 5421 2678876665 3556678888887776323444443 No 151 >1GUB_A D-ALLOSE-BINDING PERIPLASMIC PROTEIN; SUGAR-BINDING PROTEIN, PERIPLASMIC BINDING PROTEIN; 3.1A {ESCHERICHIA COLI} SCOP: c.93.1.1 Probab=97.48 E-value=1e-07 Score=95.59 Aligned_cols=218 Identities=11% Similarity=0.073 Sum_probs=124.4 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++. |+++.+...|+..++. ...+.++++. T Consensus 1 ~i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~l~ 56 (288) T 1GUB_A 1 AAEYAVVLKTLSN------------PFWVDMKKGIEDEAKTL--------GVSVDIFASPSEGDFQ----SQLQLFEDLS 56 (288) T ss_dssp CCSEEEEESCSSS------------HHHHHHHHHHHHHHHHH--------TCCEEEEECSSTTCHH----HHHHHHHHHH T ss_pred CceEEEEEccCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEEcCCCCCCHH----HHHHHHHHHH Confidence 4789999987542 25567778888888775 3455555554333321 2233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~~~~~ 202 (908) . ++++++|+...+.... .....+...++|+|..+...+.... ....++++++.+++... T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~~v~~~~~~~ 117 (288) T 1GUB_A 57 N-------------------KNYKGIAFAPLSSVNLVMPVARAWKKGIYLVNLDEKIDMDNLKKAGGNVEAFVTTDNVAV 117 (288) T ss_dssp T-------------------SCCSEEEECCSSTTTTHHHHHHHHHHTCEEEEESSCCCHHHHHHHTCCCSEEEECCHHHH T ss_pred c-------------------CCCCEEEEecCCcccchHHHHHHHHCCCeEEEECCCCChHHHhhcCCceEEEEecChHHH Confidence 2 4788777654433221 3345566789999987764431100 00135667788888777 Q NP_000836.2 203 AQAMVDIVTAL-GW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 203 ~~~~~~~l~~~-~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ++.+++++.+. +. +++++++. ++.++..+.+++++.+++.+.+.+....... .+..+....++++++. .+++ T Consensus 118 ~~~~~~~l~~~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (288) T 1GUB_A 118 GAKGASFIIDKLGAEGGEVAIIEGKAGNASGEARRNGATEAFKKASQIKLVASQPAD--WDRIKALDVATNVLQRNPNIK 195 (288) T ss_dssp HHHHHHHHHHHHTTTCEEEEEECCCSSCHHHHHHHHHHHHHHHHCTTEEEEEEECCC--SCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHhhCCceEEEEEcCCCCccHHHHHHHHHHHHHhcCCcEEeeccCCC--CcHHHHHHHHHHHHHHCCCcC Confidence 88888887553 66 88999985 3345667778888887764213332211111 1112334445555421 2466 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~~~~~~~~~~~~g~~~~~~i~~~ 226 (288) T 1GUB_A 196 AIYCAN-DTMAMGVAQAVANAGKTGKVLVVGT 226 (288) T ss_dssp EEEESS-HHHHHHHHHHHHHHTCBTTBEEEEE T ss_pred EEEECC-cccHHHHHHHHHHcCCCCCeEEEEe Confidence 676654 4456678888888776323444444 No 152 >1GUD_B D-ALLOSE-BINDING PERIPLASMIC PROTEIN; PERIPLASMIC BINDING PROTEIN, ALLOSE, HINGE; 1.71A {ESCHERICHIA COLI} SCOP: c.93.1.1 Probab=97.48 E-value=1e-07 Score=95.59 Aligned_cols=218 Identities=11% Similarity=0.073 Sum_probs=124.4 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++. |+++.+...|+..++. ...+.++++. T Consensus 1 ~i~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~~----~~~~~~~~l~ 56 (288) T 1GUD_B 1 AAEYAVVLKTLSN------------PFWVDMKKGIEDEAKTL--------GVSVDIFASPSEGDFQ----SQLQLFEDLS 56 (288) T ss_dssp CCEEEEECSCSSS------------HHHHHHHHHHHHHHHHH--------TCEEEEECCSSTTCHH----HHHHHHHHHH T ss_pred CceEEEEEccCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEEcCCCCCCHH----HHHHHHHHHH Confidence 4789999987542 25567778888888775 3455555554333321 2233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSD-NTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~-~~~~~~~~~~~~~~~~~ 202 (908) . ++++++|+...+.... .....+...++|+|..+...+.... ....++++++.+++... T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~~~~~~~~~~~v~~~~~~~ 117 (288) T 1GUD_B 57 N-------------------KNYKGIAFAPLSSVNLVMPVARAWKKGIYLVNLDEKIDMDNLKKAGGNVEAFVTTDNVAV 117 (288) T ss_dssp T-------------------TCCSEEEECCSSSSTTHHHHHHHHHTTCEEEEESSCCCHHHHHHTTCCCSEEEECCHHHH T ss_pred c-------------------CCCCEEEEecCCcccchHHHHHHHHCCCeEEEECCCCChHHHhhcCCceEEEEecChHHH Confidence 2 4788777654433221 3345566789999987764431100 00135667788888777 Q NP_000836.2 203 AQAMVDIVTAL-GW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 203 ~~~~~~~l~~~-~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ++.+++++.+. +. +++++++. ++.++..+.+++++.+++.+.+.+....... .+..+....++++++. .+++ T Consensus 118 ~~~~~~~l~~~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 195 (288) T 1GUD_B 118 GAKGASFIIDKLGAEGGEVAIIEGKAGNASGEARRNGATEAFKKASQIKLVASQPAD--WDRIKALDVATNVLQRNPNIK 195 (288) T ss_dssp HHHHHHHHHHHHTTTCEEEEEEECSTTCHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHhhCCceEEEEEcCCCCccHHHHHHHHHHHHHhcCCcEEeeccCCC--CcHHHHHHHHHHHHHHCCCcC Confidence 88888887553 66 88999985 3345667778888887764213332211111 1112334445555421 2466 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|+..++.+++. T Consensus 196 ~i~~~~-~~~~~~~~~~~~~~g~~~~~~i~~~ 226 (288) T 1GUD_B 196 AIYCAN-DTMAMGVAQAVANAGKTGKVLVVGT 226 (288) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCBTTBEEEEE T ss_pred EEEECC-cccHHHHHHHHHHcCCCCCeEEEEe Confidence 676654 4456678888888776323444444 No 153 >1DBQ_B PURINE REPRESSOR; TRANSCRIPTION REGULATION, DNA-BINDING REGULATORY PROTEIN; 2.2A {Escherichia coli} SCOP: c.93.1.1 Probab=97.47 E-value=1.1e-07 Score=95.41 Aligned_cols=205 Identities=14% Similarity=0.122 Sum_probs=114.3 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 4 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~~~ 57 (289) T 1DBQ_B 4 VNHTKSIGLLATSSEA------------AYFAEIIEAVEKNCFQKG----------YTLILGNAWNNL----EKQRAYLS 57 (289) T ss_dssp ----CEEEEEESCSSC------------TTTTHHHHHHHHHHHHTT----------CEEEEEECSSCT----THHHHHHH T ss_pred cCCccEEEEEcCCCcc------------hHHHHHHHHHHHHHHHhC----------CeEEEEecCCCH----HHHHHHHH Confidence 4567899999987542 245567777777776542 334445544332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .+++++|+...+... .....+. ..++|+|..+...+. .++.+++.+++. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~~~~ 111 (289) T 1DBQ_B 58 MMAQ-------------------KRVDGLLVMCSEYPE-PLLAMLEEYRHIPMVVMDWGEAK------ADFTDAVIDNAF 111 (289) T ss_dssp HHHH-------------------TTCSCCCEECSCCCH-HHHHHHHHTTTSCCCEEEESCCC------SSSCEEEECCHH T ss_pred HHHh-------------------cCCCEEEEecCCCCH-HHHHHHHHhCCCCEEEecCCCCC------CCCCcEEEeCHH Confidence 3332 478888875443322 2223333 479999987654321 234456667766 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..++.+++++.+.+.++++++.. +..++..+.++|.+.+++. ++.+........+.+..+....++++++. .++++ T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (289) T 1DBQ_B 112 EGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEA-MIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTA 190 (289) T ss_dssp HHHHHHHHHHHHTTCCSEEEECCC------CHHHHHHHHHHHHH-TCCCCGGGBCCCCSSHHHHHHHHHHHHSSSSCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEeCCCcccchHHHHHHHHHHHHHC-CCCCCHHHeeecCCChHHHHHHHHHHHcCCCCCCE Confidence 77788888887668889999985 3345667778888887765 34443211111001112334445555431 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 191 v~~~~-~~~a~~~~~~l~~~g~~ 212 (289) T 1DBQ_B 191 VFCGG-DIMAMGALCAADEMGLR 212 (289) T ss_dssp EEESC-HHHHHHHHHHHHHHTCC T ss_pred EEECC-HHHHHHHHHHHHHcCCC Confidence 76654 33566778888877764 No 154 >4RK0_D LacI family sugar-binding transcriptional regulator; sugar binding, transcription regulation, Enzyme; HET: RIB; 1.8A {Enterococcus faecalis V583} Probab=97.45 E-value=1.2e-07 Score=94.24 Aligned_cols=198 Identities=12% Similarity=0.122 Sum_probs=121.1 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++. | +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~--------~--~~~~~~~~~~~~~----~~~~~~~ 57 (274) T 4RK0_D 4 MKKSKTIGVIVPDITN------------PFFAQLIRGIESVLYKE--------N--FILILCNADQDVT----REHEYLT 57 (274) T ss_dssp --CCEEEEEEESCTTS------------HHHHHHHHHHHHHHTTT--------T--EEEEEEEGGGCCS----TTCHHHH T ss_pred CCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHC--------C--CEEEEEeCCCChH----HHHHHHH Confidence 4567899999987542 25667788888887764 2 3445555543322 2333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.....+...+...++|+|..+...+ .++.+++.+++.. T Consensus 58 ~~~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 111 (274) T 4RK0_D 58 ELIR-------------------RSVDGFVIASSEISNQTINETLRAKKIPFIVLDQKKA-------EGFSDAVLTDDYR 111 (274) T ss_dssp HHHT-------------------SCCSEEEECCTTSCHHHCCCCCCHHTCCEEEETTSCC-------CSSSEEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCcccCchHHHHHHHHCCCCEEEEcCCCC-------CCCCcEEEechHH Confidence 4332 4788888765544333444556778999998765432 1356677788877 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .++.+++++.+.+.++++++..+.. ++..+.++|++.+++. +..+.. .+. ..+....+++++. .++|+|+ T Consensus 112 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~--~~~----~~~~~~~~~~~~~-~~~~~i~ 183 (274) T 4RK0_D 112 GGQLAAKHLQEQRHEQVIVVMPPHAPVNIQQRLKGFCSVYTEK-VQLIET--ELS----KTGGYQAVPEILK-TESTGIF 183 (274) T ss_dssp HHHHHHHHHHHTTCCSEEEEECSSCCHHHHHHHHHHHTTCCSS-EEEEEC--CSS----HHHHHHHHHHHHT-SCCCEEE T ss_pred HHHHHHHHHHHCCCCeEEEeCCCCCchHHHHHHHHHHHHHHhc-cceecc--ccc----ccchhhHHHHHHh-cCCCEEE Confidence 8888888886666788999885433 5566777888777664 222111 111 1123344555553 3788887 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 184 ~~~-~~~~~~~~~~~~~~g~~ 203 (274) T 4RK0_D 184 AIN-DEIAFGLYRGLAEAGKK 203 (274) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred EcC-hHHHHHHHHHHHHcCCC Confidence 764 33466788888877764 No 155 >3DBI_A SUGAR-BINDING TRANSCRIPTIONAL REGULATOR, LACI FAMILY; STRUCTURAL GENOMICS, SUGAR-BINDING TRANSCRIPTIONAL REGULATOR; HET: MSE, PO4; 2.45A {Escherichia coli K12} Probab=97.45 E-value=1.3e-07 Score=97.60 Aligned_cols=207 Identities=10% Similarity=0.026 Sum_probs=121.5 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 58 ~~~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (338) T 3DBI_A 58 AKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSA----EEERQAIQ 113 (338) T ss_dssp --CCSEEEEEECTTTTS----------TTHHHHHHHHHHHHHHHTT----------CEEEEEECTTSH----HHHHHHHH T ss_pred cCCCCeEEEEecCcccc----------CccHHHHHHHHHHHHHHcC----------CEEEEEcCCCCH----HHHHHHHH Confidence 35688999999976421 1255667778887777642 344455554442 22333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .+++++|+...+.....+...++..++|+|.++...+. +..+.+..++.. T Consensus 114 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~~ 167 (338) T 3DBI_A 114 YLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHKQ 167 (338) T ss_dssp HHHH-------------------TTCSEEEECCSSSCHHHHHHHHHHCSSCEEEESSCCSS-------SGGGEECBCHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCChHHHHHHHHhcCCCEEEECCCCCC-------CCCcEEEeCCHH Confidence 4432 47888887654433334445566789999987754321 234555666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+..+.+++++. ..++|+| T Consensus 168 ~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~v 246 (338) T 3DBI_A 168 TSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSAL 246 (338) T ss_dssp HHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHHHTTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEecCCCCchHHHHHHHHHHHHHHC-CCCCCHHHeecCCCChHHHHHHHHHHHHCCCCCCEE Confidence 6777777776668889999986443 5667778888888765 3444321111100112233444555542 1247777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 247 ~~~~-~~~a~~~~~~l~~~g~~ 267 (338) T 3DBI_A 247 VASN-DDMAIGAMKALHERGVA 267 (338) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44567778888887764 No 156 >3DBI_C SUGAR-BINDING TRANSCRIPTIONAL REGULATOR, LACI FAMILY; STRUCTURAL GENOMICS, SUGAR-BINDING TRANSCRIPTIONAL REGULATOR; HET: MSE, PO4; 2.45A {Escherichia coli K12} Probab=97.45 E-value=1.3e-07 Score=97.60 Aligned_cols=207 Identities=10% Similarity=0.026 Sum_probs=121.5 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|..+.. ..++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 58 ~~~~~~Ig~i~~~~~~~----------~~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 113 (338) T 3DBI_C 58 AKSTQTLGLVVTNTLYH----------GIYFSELLFHAARMAEEKG----------RQLLLADGKHSA----EEERQAIQ 113 (338) T ss_dssp --CCSEEEEEECTTTTS----------SSHHHHHHHHHHHHHHHTT----------CEEEEEECTTSH----HHHHHHHH T ss_pred cCCCCeEEEEecCcccc----------CccHHHHHHHHHHHHHHcC----------CEEEEEcCCCCH----HHHHHHHH Confidence 35688999999976421 1255667778887777642 344455554442 22333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .+++++|+...+.....+...++..++|+|.++...+. +..+.+..++.. T Consensus 114 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~v~~~~~~ 167 (338) T 3DBI_C 114 YLLD-------------------LRCDAIMIYPRFLSVDEIDDIIDAHSQPIMVLNRRLRK-------NSSHSVWCDHKQ 167 (338) T ss_dssp HHHH-------------------TTCSEEEECCSSSCHHHHHHHHHHCSSCEEEESSCCSS-------SGGGEECBCHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCChHHHHHHHHhcCCCEEEECCCCCC-------CCCcEEEeCCHH Confidence 4432 47888887654433334445566789999987754321 234555666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+..+.+++++. ..++|+| T Consensus 168 ~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~v 246 (338) T 3DBI_C 168 TSFNAVAELINAGHQEIAFLTGSMDSPTSIERLAGYKDALAQH-GIALNEKLIANGKWTPASGAEGVEMLLERGAKFSAL 246 (338) T ss_dssp HHHHHHHHHHHTTCCSEEEECCCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHHHTTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEecCCCCchHHHHHHHHHHHHHHC-CCCCCHHHeecCCCChHHHHHHHHHHHHCCCCCCEE Confidence 6777777776668889999986443 5667778888888765 3444321111100112233444555542 1247777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 247 ~~~~-~~~a~~~~~~l~~~g~~ 267 (338) T 3DBI_C 247 VASN-DDMAIGAMKALHERGVA 267 (338) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44567778888887764 No 157 >3EGC_F putative ribose operon repressor; STRUCTURAL GENOMICS, UNKNOWN FUNCTION, DNA-binding; 2.35A {Burkholderia thailandensis} Probab=97.42 E-value=1.5e-07 Score=94.64 Aligned_cols=205 Identities=11% Similarity=0.054 Sum_probs=119.7 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|..+. .++.....+++.++++.+ +++.+.++..++. ...+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~ 57 (291) T 3EGC_F 4 RSKRSNVVGLIVSDIEN------------VFFAEVASGVESEARHKG----------YSVLLANTAEDIV----REREAV 57 (291) T ss_dssp ---CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHH T ss_pred cCCCCcEEEEEEcCccc------------HHHHHHHHHHHHHHHHcC----------CeEEEEECCCCHH----HHHHHH Confidence 34578999999987542 256677888888887753 2344445433321 223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .+++++|+...+.. ......+...++|+|..+...+ .++.+.+.++.. T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 110 (291) T 3EGC_F 58 GQFFE-------------------RRVDGLILAPSEGE-HDYLRTELPKTFPIVAVNRELR-------IPGCGAVLSENV 110 (291) T ss_dssp HHHHH-------------------TTCSEEEECCCSSC-CHHHHHSSCTTSCEEEESSCCC-------CTTCEEEEECHH T ss_pred HHHHH-------------------cCCCEEEEeCCCCC-hHHHHhhcCCCCCEEEECCCCC-------CCCCcEEEeCcH Confidence 43332 47888887654433 3344556678999998776433 134667777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++.. ++.....+.++|++.+++. ++++........+.+..+....+++++. ..++++ T Consensus 111 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 189 (291) T 3EGC_F 111 RGARTAVEYLIARGHTRIGAIVGSAGLMTSRERLKGFRAAMSAA-GLPVRQEWIAAGGVRADNGRDGAIKVLTGADRPTA 189 (291) T ss_dssp HHHHHHHHHHHHTTCCSEEEECSSTTSHHHHHHHHHHHHHHHHT-TCCCCGGGEEC------CCHHHHHHHHTSTTCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEeCCCCcccHHHHHHHHHHHHHHc-CCCCChheEeecCCchhhHHHHHHHHHhCCCCCCE Confidence 77778888876668889999985 3345566778888888765 3443321111100111122334444432 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 190 i~~~~-~~~a~~~~~~l~~~g~~ 211 (291) T 3EGC_F 190 LLTSS-HRITEGAMQALNVLGLR 211 (291) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHcCCC Confidence 77664 44466777888877764 No 158 >4KZK_A L-arabinose-binding protein; L-arabinose, BETA-D-GALACTOSE, ABC transporter, periplasmic; HET: GAL; 1.5A {Burkholderia thailandensis} Probab=97.41 E-value=1.6e-07 Score=96.80 Aligned_cols=218 Identities=11% Similarity=0.069 Sum_probs=122.1 Template_Neff=11.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++.....+++.++++.+ +++.+.|+ .++ +...+. T Consensus 31 ~~~~~~~~Ig~~~~~~~~------------~~~~~~~~~~~~a~~~~~----------~~~~~~~~-~~~----~~~~~~ 83 (337) T 4KZK_A 31 AQGAAPVKIGFVVKQPDD------------PWFQDEWRFAEQAAKDKH----------FTLVKIAA-PSG----EKVSTA 83 (337) T ss_dssp ------CEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEEC-CSH----HHHHHH T ss_pred hcCCCCeEEEEEECCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEeC-CCH----HHHHHH Confidence 455678999999985432 245667778888877652 33444454 332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|.++...+.... ...++++++.++ T Consensus 84 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d 143 (337) T 4KZK_A 84 LDSLAA-------------------QKAQGVIICAPDVKLGPGIAAKAKRYGMKLMSVDDQLVDGRG-APLADVPHMGIS 143 (337) T ss_dssp HHHHHH-------------------TTCSEEEEECSSGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCTTSCEEEEC T ss_pred HHHHHh-------------------cCCCEEEEcCCCCcccHHHHHHHHHcCCEEEEEecCCCCCCC-CCcccCcEEecC Confidence 443332 47787776544332 233445667789999988765432111 113567777788 Q NP_000836.2 199 DSYQAQAMVDIVTA----LGWN--YVSTLASE---GNYGESGVEAFTQISREIGGVC---IAQSQKIPREPRPGEFEKII 266 (908) Q Consensus 199 ~~~~~~~~~~~l~~----~~~~--~v~ii~~~---~~~~~~~~~~~~~~~~~~~~i~---v~~~~~~~~~~~~~~~~~~~ 266 (908) +...++.+++++.+ .+++ +++++..+ +.++..+.++|++.+++. +.. +....... .+..+....+ T Consensus 144 ~~~~~~~~~~~l~~~~~~~g~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~--~~~~~~~~~~ 220 (337) T 4KZK_A 144 AYRIGRQVGDAIAAEAKRRGWNPAEVGVLRLAYDQLPTARERTTGAVDALKAA-GFAAANVVDAPEMT--ADTEGAFNAA 220 (337) T ss_dssp HHHHHHHHHHHHHHHHHHTTCCGGGCEEEEEECTTSHHHHHHHHHHHHHHHHT-TCCGGGEEEEECSS--SSHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHcCCCCccEEEEEecCCCChHHHHHHHHHHHHHHHc-CCccceeeccccCC--CCHHHHHHHH Confidence 77778888887754 4666 89998754 456667788888888765 333 22111111 1122344555 Q NP_000836.2 267 KRLLETPNARA---VIMFANEDDIRRILEAAKKLNQSG-HFLWIGS 308 (908) Q Consensus 267 ~~l~~~~~~~v---iv~~~~~~~~~~~l~~~~~~g~~~-~~~~i~~ 308 (908) +++++ .+++. +++..++..+..+++++++.|+.. ++.+++. T Consensus 221 ~~~~~-~~~~~~~~~i~~~~~~~a~~~~~~l~~~g~~~~~i~i~g~ 265 (337) T 4KZK_A 221 NIAFT-KHRNFRHWVAFGSNDDTTVGAVRAGEGRGIGTDDMIAVGI 265 (337) T ss_dssp HHHHH-HCTTCSSEEEECSSHHHHHHHHHHHHHTTCCGGGEEEEEE T ss_pred HHHHH-hCCCCCeEEEEecChHHHHHHHHHHHHcCCCCCCeEEEEe Confidence 66653 34443 233334555677888888877631 3444443 No 159 >3O1I_C Sensor protein TorS (E.C.2.7.13.3), Periplasmic; Ligand free, Two component sensor; HET: PE4; 2.8A {Vibrio parahaemolyticus} Probab=97.41 E-value=1.6e-07 Score=95.14 Aligned_cols=216 Identities=7% Similarity=-0.002 Sum_probs=120.4 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.... ..+..+..+++.++++.+ +++.+...|...++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~~~~ 58 (304) T 3O1I_C 3 GSDEKICAIYPHLKD------------SYWLSVNYGMVSEAEKQG--------VNLRVLEAGGYPNKS----RQEQQLAL 58 (304) T ss_dssp --CCEEEEEESCSCS------------HHHHHHHHHHHHHHHHHT--------CEEEEEECSSTTCHH----HHHHHHHH T ss_pred CCCceEEEEEccCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEEcCCCCCCHH----HHHHHHHH Confidence 467899999987432 245677788888888753 455555444322321 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+. .++|+|..+...+... ....++.+++.++... T Consensus 59 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~~~-~~~~~~~~~v~~d~~~ 117 (304) T 3O1I_C 59 CTQ-------------------WGANAIILGTVDPHAYEHNLKSWV-GNTPVFATVNQLDLDE-EQSTLLKGEVGVDWYW 117 (304) T ss_dssp HHH-------------------HTCSEEEECCSSTTSSTTTHHHHT-TTSCEEECSSCCCCCT-TTGGGEEEECCCCHHH T ss_pred HHH-------------------hCCCEEEEcCCCHHhHHHHHHHHh-cCCCEEEEecCCCCCh-HHhhcceEEEEcChHH Confidence 332 47888877543322 223334455 6999988765433211 0113567788888877 Q NP_000836.2 202 QAQAMVDIVTAL-----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 202 ~~~~~~~~l~~~-----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. ++++....... ....+....++++++..+ T Consensus 118 ~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 194 (304) T 3O1I_C 118 MGYEAGKYLAERHPKGSGKTNIALLLGPRTRGGTKPVTTGFYEAIKNS-DIHIVDSFWAD--NDKELQRNLVQRVIDMGN 194 (304) T ss_dssp HHHHHHHHHHTTSBTTTCCEEEEEECCCC-----CHHHHHHHHTTTTB-TEEEEECCCCC--SCHHHHHHHHHHHHHHSC T ss_pred HHHHHHHHHHHHCCCCCCCeEEEEEeCCCCCCcchHHHHHHHHHHhcC-CcEEeeeeecC--CCHHHHHHHHHHHHHcCC Confidence 788888887554 6678999985 3335667788888888764 35443221111 111233344555542235 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++ .+..+++++++.|+..++.+++. T Consensus 195 ~~~i~~~-~~-~~~~~~~~~~~~g~~~~~~v~~~ 226 (304) T 3O1I_C 195 IDYIVGS-AV-AIEAAISELRSADKTHDIGLVSV 226 (304) T ss_dssp CSEEEEC-HH-HHHHHHHHHTTTTCGGGSEEBCS T ss_pred CCEEEEc-ch-HHHHHHHHHHHCCCCCCeEEEEE Confidence 6666554 33 56778888887776323444443 No 160 >3O1I_D Sensor protein TorS (E.C.2.7.13.3), Periplasmic; Ligand free, Two component sensor; HET: PE4; 2.8A {Vibrio parahaemolyticus} Probab=97.41 E-value=1.6e-07 Score=95.14 Aligned_cols=216 Identities=7% Similarity=-0.002 Sum_probs=122.7 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.... ..+..+..+++.++++.+ +++.+...|...++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~~~~ 58 (304) T 3O1I_D 3 GSDEKICAIYPHLKD------------SYWLSVNYGMVSEAEKQG--------VNLRVLEAGGYPNKS----RQEQQLAL 58 (304) T ss_dssp --CCEEEEEESCSCS------------HHHHHHHHHHHHHHHTTT--------CEEEEEECSSTTCHH----HHHHHHHH T ss_pred CCCceEEEEEccCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEEcCCCCCCHH----HHHHHHHH Confidence 467899999987432 245677788888888753 455555444322321 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+. .++|+|..+...+... ....++.+++.++... T Consensus 59 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~~~-~~~~~~~~~v~~d~~~ 117 (304) T 3O1I_D 59 CTQ-------------------WGANAIILGTVDPHAYEHNLKSWV-GNTPVFATVNQLDLDE-EQSTLLKGEVGVDWYW 117 (304) T ss_dssp HHH-------------------HTCSEEEECCSCGGGSTTTTHHHH-TTCCEEECSSCCCCCT-TGGGGEEEECCCCTHH T ss_pred HHH-------------------hCCCEEEEcCCCHHhHHHHHHHHh-cCCCEEEEecCCCCCh-HHhhcceEEEEcChHH Confidence 332 47888877543322 223334455 6999988765433211 0113567788888877 Q NP_000836.2 202 QAQAMVDIVTAL-----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 202 ~~~~~~~~l~~~-----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. ++++....... ....+....++++++..+ T Consensus 118 ~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 194 (304) T 3O1I_D 118 MGYEAGKYLAERHPKGSGKTNIALLLGPRTRGGTKPVTTGFYEAIKNS-DIHIVDSFWAD--NDKELQRNLVQRVIDMGN 194 (304) T ss_dssp HHHHHHHHHHTTSCTTSCCEEEEEECCSSSTTTSHHHHHHHHHHHHSS-SEEEEEECCCC--SCHHHHHHHHHHHHHHSC T ss_pred HHHHHHHHHHHHCCCCCCCeEEEEEeCCCCCCcchHHHHHHHHHHhcC-CcEEeeeeecC--CCHHHHHHHHHHHHHcCC Confidence 788888887554 6678999985 3335667788888888764 35443221111 111233344555542235 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++ .+..+++++++.|+..++.+++. T Consensus 195 ~~~i~~~-~~-~~~~~~~~~~~~g~~~~~~v~~~ 226 (304) T 3O1I_D 195 IDYIVGS-AV-AIEAAISELRSADKTHDIGLVSV 226 (304) T ss_dssp CSEEEEC-HH-HHHHHHHHHHHTTCTTTSEEEES T ss_pred CCEEEEc-ch-HHHHHHHHHHHCCCCCCeEEEEE Confidence 6666554 33 56778888887776323444443 No 161 >3O1J_C Sensor protein TorS (E.C.2.7.13.3), Periplasmic; Isopropanol bound, Two component sensor; 2.95A {Vibrio parahaemolyticus} Probab=97.41 E-value=1.6e-07 Score=95.14 Aligned_cols=216 Identities=7% Similarity=-0.002 Sum_probs=120.7 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|.... ..+..+..+++.++++.+ +++.+...|...++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~~~~ 58 (304) T 3O1J_C 3 GSDEKICAIYPHLKD------------SYWLSVNYGMVSEAEKQG--------VNLRVLEAGGYPNKS----RQEQQLAL 58 (304) T ss_dssp --CCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT--------CEEEEEECSSTTCHH----HHHHHHHH T ss_pred CCCceEEEEEccCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEEcCCCCCCHH----HHHHHHHH Confidence 467899999987432 245677788888888753 455555444322321 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+. .++|+|..+...+... ....++.+++.++... T Consensus 59 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~~~-~~~~~~~~~v~~d~~~ 117 (304) T 3O1J_C 59 CTQ-------------------WGANAIILGTVDPHAYEHNLKSWV-GNTPVFATVNQLDLDE-EQSTLLKGEVGVDWYW 117 (304) T ss_dssp HHH-------------------HTCSEEEECCSSSSTTSSCSTTTT-TTCCEEECSSCCCCCH-HHHTTEEEEECCCHHH T ss_pred HHH-------------------hCCCEEEEcCCCHHhHHHHHHHHh-cCCCEEEEecCCCCCh-HHhhcceEEEEcChHH Confidence 332 47888877543322 223334455 6999988765433211 0113567788888877 Q NP_000836.2 202 QAQAMVDIVTAL-----GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 202 ~~~~~~~~l~~~-----~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. ++++....... ....+....++++++..+ T Consensus 118 ~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 194 (304) T 3O1J_C 118 MGYEAGKYLAERHPKGSGKTNIALLLGPRTRGGTKPVTTGFYEAIKNS-DIHIVDSFWAD--NDKELQRNLVQRVIDMGN 194 (304) T ss_dssp HHHHHHHHHHHHSCTTSCCEEEEEEEECCC----THHHHHHHHHHSSS-SEEEEEEEECC--SCHHHHHHHHHHHHHTCC T ss_pred HHHHHHHHHHHHCCCCCCCeEEEEEeCCCCCCcchHHHHHHHHHHhcC-CcEEeeeeecC--CCHHHHHHHHHHHHHcCC Confidence 788888887554 6678999985 3335667788888888764 35443221111 111233344555542235 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++ .+..+++++++.|+..++.+++. T Consensus 195 ~~~i~~~-~~-~~~~~~~~~~~~g~~~~~~v~~~ 226 (304) T 3O1J_C 195 IDYIVGS-AV-AIEAAISELRSADKTHDIGLVSV 226 (304) T ss_dssp CSEEEEC-HH-HHHHHHHHHHHTTCTTTSEEEES T ss_pred CCEEEEc-ch-HHHHHHHHHHHCCCCCCeEEEEE Confidence 6666554 33 56778888887776323444443 No 162 >4YHS_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE, BTB; 1.8A {Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)} Probab=97.41 E-value=1.6e-07 Score=97.66 Aligned_cols=215 Identities=11% Similarity=0.036 Sum_probs=122.9 Template_Neff=10.800 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++..+..+++.++++. |+++.+...|+..++ ....+. T Consensus 53 ~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~l~~~~~~~~~~~----~~~~~~ 108 (354) T 4YHS_A 53 EKASKPWKLCVSFPHMKD------------AYWLGVDYGVAEESKRL--------GVKMNLVEAGGYTEL----NKQISQ 108 (354) T ss_dssp SCCSSCCEEEEEESCCCS------------HHHHHHHHHHHHHHHHH--------TCEEEEEECSSTTCH----HHHHHH T ss_pred ccCCCCeEEEEEeCCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEEecCCCCCH----HHHHHH Confidence 345678999999987542 24567778888888774 345655555432232 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+.. .+.........+.+.++|+|.++...+. .++.+++.++ T Consensus 109 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 163 (354) T 4YHS_A 109 IEDCVA-------------------SGTDAVIIGAISADGLNKVIGEIAKKKIPVIDLVNGISS------PDIAAKSLVS 163 (354) T ss_dssp HHHHHH-------------------HCCSEEEECCSSSSTTHHHHHHHHTTTCCEEEESSCCCC------TTCCEEECCC T ss_pred HHHHHH-------------------cCCCEEEEcCCCHHhhHHHHHHHHhcCCCEEEEcCCCCC------hhhceEeecC Confidence 444332 4677776543 3322334455667789999987654321 2445667777 Q NP_000836.2 199 DSYQAQAMVDIVTAL---GWNYVSTLA----SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 199 ~~~~~~~~~~~l~~~---~~~~v~ii~----~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) ....++.+++++.+. +.+++++++ .+..++..+.++|++.+++. ++.+....... .+..+....++++++ T Consensus 164 ~~~~~~~~~~~l~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~g~~~~~~~~-g~~~~~~~~~~--~~~~~~~~~~~~~l~ 240 (354) T 4YHS_A 164 FYTMGAETGSYLAKKHPAGTPEVVVGWFPGPAGAGWVEAANKGFMDAVKGS-AIKVLEPKYGD--TGKEVQAKLVEDALQ 240 (354) T ss_dssp HHHHHHHHHHHHHHHSCTTSCCEEEEEECSSTTCHHHHHHHHHHHHHHTTS-SEEECCCCCCC--SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHCCCCCCcEEEEEEcCCCCChHHHHHHHHHHHHHcCC-CcEEEccccCC--CCHHHHHHHHHHHHH Confidence 777777888887654 778888863 12334566778888877764 35443221111 111233344555542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) . .++++|+.. +..+..+++++++.|+..++.+++. T Consensus 241 ~~~~~~~i~~~--~~~a~~~~~~l~~~g~~~~v~i~g~ 276 (354) T 4YHS_A 241 AAPNIRYVAGT--AVTAEAAQGLIRERGLKGKVDLLAF 276 (354) T ss_dssp HCTTCCEEEEC--HHHHHHHHHHHHHTTCBTTBEEEES T ss_pred HCCCCCEEEEC--chHHHHHHHHHHHCCCCCCcEEEEE Confidence 1 245555443 3456777888887776323334443 No 163 >3CLK_B Transcription regulator; 11017j, PSI-II, NYSGXRC, dimer, Structural; 2.08A {Lactobacillus plantarum WCFS1} Probab=97.41 E-value=1.6e-07 Score=94.34 Aligned_cols=205 Identities=11% Similarity=0.084 Sum_probs=114.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|..+. .++.....+++.++++. |+++.+...+. .++ ....+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~-~~~----~~~~~~~ 58 (290) T 3CLK_B 4 VKKSSNVIAAVVSSVRT------------NFAQQILDGIQEEAHKN--------GYNLIIVYSGS-ADP----EEQKHAL 58 (290) T ss_dssp ------CEEEEEC----------------CHHHHHHHHHHHHHTTT--------TCCEEEEC-----------CHHHHHH T ss_pred ccCCCCEEEEEECCCCC------------hHHHHHHHHHHHHHHHc--------CCeEEEEeCCC-CCH----HHHHHHH Confidence 34568999999987542 25566778888887765 34454443332 221 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|+...+.. ......+...++|+|..+...+ +.++.+.+++. T Consensus 59 ~~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~ 110 (290) T 3CLK_B 59 LTAIE-------------------RPVMGILLLSIALT-DDNLQLLQSSDVPYCFLSMGFD--------DDRPFISSDDE 110 (290) T ss_dssp HHHHH-------------------SCCSEEEEESCCCC-HHHHHHHHHTTCCEEEESCCCS--------SSCCEEECCHH T ss_pred HHHHh-------------------CCCCEEEEecccCC-hHHHHHHHhCCCCEEEEccCCC--------CCCCEEeeCcH Confidence 33332 47888887654433 3444566778999998765432 24566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+.++++++..+.. ++..+.+++++.+++. ++.+........+.+..+....++++....++|+| T Consensus 111 ~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~i 189 (290) T 3CLK_B 111 DIGYQATNLLINEGHRQIGIAGIDQYPYTGRKRLAGYKKALKEA-NIAINQEWIKPGDYSYTSGEQAMKAFGKNTDLTGI 189 (290) T ss_dssp HHHHHHHHHHHTTTCCSEEEESCCCSSHHHHHHHHHHHHHHHHT-TCCCCGGGEECCCSSHHHHHHHHHHHCTTCCCSEE T ss_pred HHHHHHHHHHHHCCCCCEEEEcCCCCCccchHHHHHHHHHHHHC-CCCCChhhccCCCCChhhHHHHHHHHhhCCCCCEE Confidence 77888888887668889999985443 5566778888888765 34443211111001112233444444322467888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 190 ~~~~-~~~~~~~~~~l~~~g~~ 210 (290) T 3CLK_B 190 IAAS-DMTAIGILNQASSFGIE 210 (290) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 33466778888877764 No 164 >2RGY_A Transcriptional regulator, LacI family; 11011j, NYSGXRC, Transctiptional regulator, LacI; 2.05A {Burkholderia phymatum} Probab=97.40 E-value=1.6e-07 Score=94.18 Aligned_cols=208 Identities=13% Similarity=0.021 Sum_probs=118.5 Template_Neff=12.000 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..+++++||++.|..+. .++..+..+++.++++. |+++.+...++..+. .+...+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~---~~~~~~~~ 60 (290) T 2RGY_A 4 ATQQLGIIGLFVPTFFG------------SYYGTILKQTDLELRAV--------HRHVVVATGCGESTP---REQALEAV 60 (290) T ss_dssp ----CCEEEEECSCSCS------------HHHHHHHHHHHHHHHHT--------TCEEEEECCCSSSCH---HHHHHHHH T ss_pred ccCCCceEEEEecCCCC------------chHHHHHHHHHHHHHHC--------CCeEEEEeCCCCCCh---HHHHHHHH Confidence 44578999999997542 25566777877666653 344544433321111 11222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. .++|++|+...+... .....+.+.++|+|..+...+ .++.+++..++. T Consensus 61 ~~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~ 113 (290) T 2RGY_A 61 RFLIG-------------------RDCDGVVVISHDLHD-EDLDELHRMHPKMVFLNRAFD-------ALPDASFCPDHR 113 (290) T ss_dssp HHHHH-------------------TTCSEEEECCSSSCH-HHHHHHHHHCSSEEEESSCCT-------TSGGGEECCCHH T ss_pred HHHhh-------------------CCCCEEEEEcCCCCH-HHHHHHHHcCCcEEEECCCCC-------CCCCceeecChH Confidence 33322 478888875544332 444556678999988765432 134566667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNY--GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~--~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..+..+++++.+.+.++++++..+..+ +..+.+++++.+++. ++.+........+.+..+....+++++.. .++++ T Consensus 114 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 192 (290) T 2RGY_A 114 RGGELAAATLIEHGHRKLAVISGPFTASDNVERLDGFFDELARH-GIARDSVPLIESDFSPEGGYAATCQLLESKAPFTG 192 (290) T ss_dssp HHHHHHHHHHHHTTCCSEEEEESCTTCHHHHHHHHHHHHHHHTT-TCCGGGSCEEECCSSHHHHHHHHHHHHHHTCCCSE T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCCccHHHHHHHHHHHHHHC-CCCCCCCcEEEcCCChHHHHHHHHHHHhCCCCCCE Confidence 777788888766688899999865433 556777888877764 34332111111001122334445555421 24788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 193 i~~~~-~~~a~~~~~~l~~~g~~ 214 (290) T 2RGY_A 193 LFCAN-DTMAVSALARFQQLGIS 214 (290) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 87664 44567788888887764 No 165 >6HB0_A ABC transporter periplasmic-binding protein YtfQ; periplasmic binding protein, SUGAR BINDING; HET: ZN; 1.9A {Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)} Probab=97.39 E-value=1.8e-07 Score=95.75 Aligned_cols=211 Identities=12% Similarity=0.058 Sum_probs=120.2 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ...+ T Consensus 13 ~~~~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~ 66 (322) T 6HB0_A 13 GSAPDGALTLGFAQVGAES------------GWRTANTESIKSAAEEAG----------VNLKFADANGEQE----KQIS 66 (322) T ss_dssp -----CCCEEEEEECC---------------CCSCCCHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHH T ss_pred CCCCCCCeEEEEEeeCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEECCCCCHH----HHHH Confidence 4566789999999997642 255667788888887753 3344555443322 2233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. .+++++|....+ .........+...++|+|..+...+.. ...++.+++.+ T Consensus 67 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~ 124 (322) T 6HB0_A 67 AIRSFIQ-------------------QGVDVIAFSPVVRTGWDAVLQETKNAGIPVILTDRAVDTQ---DTDVYKTFIGA 124 (322) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSSSSCHHHHHHHHHTTCCEEEESSCCCCS---SSSSCSEEECC T ss_pred HHHHHHH-------------------cCCCEEEECCCCcccHHHHHHHHHHCCCCEEEECCCCCCC---CCchhceEEec Confidence 3443332 367766653332 222344455667899999877644321 11345677788 Q NP_000836.2 198 PDSYQAQAMVDIVTA-----LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL 270 (908) Q Consensus 198 ~~~~~~~~~~~~l~~-----~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~ 270 (908) ++...++.+++++.+ .+.++++++.. ++.++..+.++|++.+++.+++++....... .+..+....+++++ T Consensus 125 d~~~~~~~~~~~l~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~~~~~~~~ 202 (322) T 6HB0_A 125 DFIEEGRRAGQWVADQYASATGPVNIVQLEGTTGADPAIDRKTGFAEGISKNPNLKIVASQTGD--FTRSGGKQVMEAFL 202 (322) T ss_dssp CHHHHHHHHHHHHHHHTTTCSSCEEEEEEECSTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TSHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHhcCCCeEEEEEEcCCCCchHHHHHHHHHHHHhhCCCcEEEEeecCC--CCHHHHHHHHHHHH Confidence 877778888887754 47789999985 3456667788888887764224443221111 11123344555554 Q NP_000836.2 271 E-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 271 ~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) . ..++++|++.. +..+..+++++++.|+. T Consensus 203 ~~~~~~d~i~~~~-~~~a~~~~~~~~~~g~~ 232 (322) T 6HB0_A 203 KSTPQIDVVFAQN-DDMGLGAMEAIEAAGKK 232 (322) T ss_dssp HHCSCCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHCCCcCEEEECC-HHHHHHHHHHHHHcCCC Confidence 2 13567776654 34556778888877764 No 166 >1SXG_D Glucose-resistance amylase regulator; allosterism phosphoprotein transcription; HET: 171; 2.75A {Bacillus megaterium} SCOP: c.93.1.1 Probab=97.39 E-value=1.8e-07 Score=93.21 Aligned_cols=204 Identities=11% Similarity=0.116 Sum_probs=120.8 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++..+..+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 58 (280) T 1SXG_D 5 SKKTTTVGVIIPDISN------------IFYAELARGIEDIATMYK----------YNIILSNSDQNQ----DKELHLLN 58 (280) T ss_dssp -CCCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred CCCCCeEEEEeCCccc------------HHHHHHHHHHHHHHHHcC----------CeEEEeeCCCCH----HHHHHHHH Confidence 4568999999987542 245667778887776642 334445544332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+. .......+...++|+|..+...+ .++.+++.+++.. T Consensus 59 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 111 (280) T 1SXG_D 59 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 111 (280) T ss_dssp HHHH-------------------TCCSEEEECCSCC-CHHHHHHHHHCSSCEEEESCCCT-------TCCSCEEEECHHH T ss_pred HHHc-------------------CCCCEEEEeCCCC-CHHHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 4332 4788888755443 33444556678999998765322 2346677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+.....+..+.+..+....+++++.. .++++ T Consensus 112 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (280) T 1SXG_D 112 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 190 (280) T ss_dssp HHHHHHHHHHTTSCSCEEEEESCTTSHCCCCCCHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHTTSSSCCSE T ss_pred HHHHHHHHHHHCCCCeEEEEeCCCCCcccHHHHHHHHHHHHHHc-CCCCCHHHeeecCCChhhHHHHHHHHHHcCCCCCE Confidence 7888888876667889999985433 4556778888887765 34433221111001122334445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 191 v~~~~-~~~~~~~~~~l~~~g~~ 212 (280) T 1SXG_D 191 IFVGT-DEMALGVIHGAQDRGLN 212 (280) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 76654 34566777888877763 No 167 >2NZV_G Catabolite control protein, Phosphocarrier protein; CCpA, HPrser46-p, CCR, fructose-bis-phosphate, adjunct; HET: SEP, SO4, FBP; 3.0A {Bacillus megaterium} SCOP: c.93.1.1 Probab=97.39 E-value=1.8e-07 Score=93.21 Aligned_cols=204 Identities=11% Similarity=0.116 Sum_probs=120.8 Template_Neff=12.200 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++..+..+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 58 (280) T 2NZV_G 5 SKKTTTVGVIIPDISN------------IFYAELARGIEDIATMYK----------YNIILSNSDQNQ----DKELHLLN 58 (280) T ss_dssp -CCCSEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred CCCCCeEEEEeCCccc------------HHHHHHHHHHHHHHHHcC----------CeEEEeeCCCCH----HHHHHHHH Confidence 4568999999987542 245667778887776642 334445544332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+. .......+...++|+|..+...+ .++.+++.+++.. T Consensus 59 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 111 (280) T 2NZV_G 59 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 111 (280) T ss_dssp HHHH-------------------TCCSCEEECCSCC-CHHHHHHTTSCSSCEEEESCCCT-------TCCSCEEEECHHH T ss_pred HHHc-------------------CCCCEEEEeCCCC-CHHHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 4332 4788888755443 33444556678999998765322 2346677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+.....+..+.+..+....+++++.. .++++ T Consensus 112 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (280) T 2NZV_G 112 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 190 (280) T ss_dssp HHHHHHHHHHHHHCSCEEEECSCTTSHHCCCCCCHHHHHHHHTT-CCCCCTTSEECCCSSHHHHHHHHHHHHTSSSCCSE T ss_pred HHHHHHHHHHHCCCCeEEEEeCCCCCcccHHHHHHHHHHHHHHc-CCCCCHHHeeecCCChhhHHHHHHHHHHcCCCCCE Confidence 7888888876667889999985433 4556778888887765 34433221111001122334445555421 24677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 191 v~~~~-~~~~~~~~~~l~~~g~~ 212 (280) T 2NZV_G 191 IFVGT-DEMALGVIHGAQDRGLN 212 (280) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 76654 34566777888877763 No 168 >4RS3_A ABC transporter, carbohydrate uptake transporter-2; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: XYL, MSE, IMD, ACT, ZN, CL; 1.4A {Mycobacterium smegmatis str. MC2 155} Probab=97.37 E-value=1.9e-07 Score=95.69 Aligned_cols=213 Identities=13% Similarity=0.075 Sum_probs=120.1 Template_Neff=11.500 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. ++.....+++.++++.+ +++.+.|+..++. ...+. T Consensus 7 ~~~~~~~~Ig~v~~~~~~-------------~~~~~~~g~~~~~~~~~----------~~l~~~~~~~~~~----~~~~~ 59 (327) T 4RS3_A 7 AANSDTKRIGVTVYDMSS-------------FITEGKEGMDTYAKANN----------IELVWNSANNDVS----TQASQ 59 (327) T ss_dssp -----CEEEEEEESCCCH-------------HHHHHHHHHHHHHHHTT----------EEEEEEECTTCHH----HHHHH T ss_pred cccCCCcEEEEEECCccH-------------HHHHHHHHHHHHHHHCC----------cEEEEecCCCCHH----HHHHH Confidence 345678999999987532 44566777777776632 3445555543322 22333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+... ......+...++|+|.++...+. .++++++.++ T Consensus 60 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 114 (327) T 4RS3_A 60 VDSLIN-------------------QGVDAIIVVPVQADSLGPQVASAKSKGIPLLAVNAALET------PDLAGNVQPD 114 (327) T ss_dssp HHHHHH-------------------HTCSEEEEECSCSSCCHHHHHHHHHTTCCEEEESSCCCC------TTCSEEEEEC T ss_pred HHHHHh-------------------CCCCEEEEecCCccccHHHHHHHHHCCCCEEEEcCCCCC------CCcceEecCC Confidence 343332 467877765443322 23344556679999987654321 2345677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...+..+++++.+. +.++++++.. ++.++..+.++|++.+++.+++++....... .+..+....++++++. T Consensus 115 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 192 (327) T 4RS3_A 115 DVAAGAQEMQMMADRLGGKGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTAN--WKRDEAVNKMKNWISSFG 192 (327) T ss_dssp HHHHHHHHHHHHHHHHTTCEEEEEEECSTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred hHHHHHHHHHHHHHHhCCCcEEEEEECCCCChhHHHHHHHHHHHHHhCCCcEEEEeecCC--CCHHHHHHHHHHHHHHhc Confidence 777777888887654 7789999885 3445666777888777664223332211111 1122344445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++.. +..+..+++++++.|+. ++.+++. T Consensus 193 ~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~i~i~g~ 226 (327) T 4RS3_A 193 PQIDGVVAQN-DDMGLGALQALKEAGRT-GVPIVGI 226 (327) T ss_dssp GGCCEEEESS-HHHHHHHHHHHHHTTCC-CCCEECS T ss_pred CCCCEEEECC-hHHHHHHHHHHHHcCCC-CCCEEEe Confidence 2377776664 44566788888887763 2344443 No 169 >5OCP_A Periplasmic binding protein/LacI transcriptional regulator; ABC transporter, periplasmic, binding protein; HET: FUB, GOL, AHR; 1.7A {Shewanella sp. ANA-3} Probab=97.36 E-value=2e-07 Score=94.25 Aligned_cols=203 Identities=14% Similarity=0.084 Sum_probs=118.2 Template_Neff=11.600 Q NP_000836.2 47 ILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEK 126 (908) Q Consensus 47 ~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~~ 126 (908) +||+++|.... .++..+..+++.++++.+ +++.+.|+..++. ...+.+++++. T Consensus 2 ~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~l~~~~~~~~~~----~~~~~~~~l~~- 54 (302) T 5OCP_A 2 TVGFSQVGSES------------GWRTSFSEAVKAEAKQRG----------IDLKFADAQQKQE----NQIKAVRSFIA- 54 (302) T ss_dssp EEEEEECCCSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHHHHH- T ss_pred eEEEecCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEecCCCCHH----HHHHHHHHHHH- Confidence 67888764322 255677788888887642 3445555544322 22333443332 Q NP_000836.2 127 DASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQA 205 (908) Q Consensus 127 ~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~ 205 (908) ++++++|+...+... ......+...++|+|..+...+.. ...++++++.+++...++. T Consensus 55 ------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~---~~~~~~~~v~~d~~~~~~~ 113 (302) T 5OCP_A 55 ------------------QGVDAIIIAPVVETGWKPVLKEAKRAKIPVVIVDRNIKVD---DDSLFLTRIASDFSEEGRK 113 (302) T ss_dssp ------------------TTCSEEEECCSSSSSCHHHHHHHHHTTCCEEEESSCCCCS---CGGGCSEEEECCHHHHHHH T ss_pred ------------------cCCCEEEEcCCCcCChHHHHHHHHHCCCCEEEEcCCCCCC---ccccceEEEcCCchHHHHH Confidence 467877765443332 244556677899999887654321 1235677888888777888 Q NP_000836.2 206 MVDIVTAL--GWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET---PNARAV 278 (908) Q Consensus 206 ~~~~l~~~--~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~---~~~~vi 278 (908) +++++.+. +.++++++..+.. ++..+.++|++.+++.+...+....... .+..+....++++++. .++|+| T Consensus 114 ~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~d~i 191 (302) T 5OCP_A 114 IGQWLMDKTQGNCDIAELQGTVGATAAIDRAAGFNQVIANYPNAKIVRSQTGE--FTRAKGKEVMEGFLKAQNGQPLCAV 191 (302) T ss_dssp HHHHHHHHTTTCEEEEEEECCTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHTTCCCCEE T ss_pred HHHHHHHHcCCCeeEEEEEcCCCCHHHHHHHHHHHHHHHhCCCcEEEEeeeCC--CCHHHHHHHHHHHHHHcCCCCccEE Confidence 88887654 7889999985433 5667778888877764222222111111 1112333444554421 357787 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 192 ~~~~-~~~a~~~~~~l~~~g~~ 212 (302) T 5OCP_A 192 WSHN-DEMALGAVQAIKEAGLK 212 (302) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44566788888877764 No 170 >3BIL_A Probable LacI-family transcriptional regulator; STRUCTURAL GENOMICS, UNKNOWN FUNCTION, PSI-2; 2.5A {Corynebacterium glutamicum ATCC 13032} Probab=97.36 E-value=2.1e-07 Score=96.38 Aligned_cols=202 Identities=11% Similarity=0.033 Sum_probs=116.9 Template_Neff=11.400 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 63 ~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 116 (348) T 3BIL_A 63 SSRSNTIGVIVPSLIN------------HYFAAMVTEIQSTASKAG----------LATIITNSNEDA----TTMSGSLE 116 (348) T ss_dssp -----CEEEEESCSSS------------HHHHHHHHHHHHHHHHTT----------CCEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEEcCCCC------------hHHHHHHHHHHHHHHHCC----------CEEEEEcCCCCh----hhhhHHHH Confidence 4567899999987542 255667778887777642 334455544332 22233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. +++|++|+...+. .......+...++|+|..+...+. .++++.+..+... T Consensus 117 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~~~~ 170 (348) T 3BIL_A 117 FLTS-------------------HGVDGIICVPNEE-CANQLEDLQKQGMPVVLVDRELPG------DSTIPTATSNPQP 170 (348) T ss_dssp HHHH-------------------TTCSCEEECCCGG-GHHHHHHHHHC-CCEEEESSCCSC------C-CCCEEEEECHH T ss_pred HHHH-------------------cCCCEEEECCccc-cHHHHHHHHHcCCCEEEEcCCCCC------CCCCCEEEeCcHH Confidence 4332 4788888755443 334445566789999987764431 2345666666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .+..+++++.+.+.++++++..+. .++..+.++|++.+++. ++.+....... .+..+....+++++. .++|+|+ T Consensus 171 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~-~~~d~i~ 246 (348) T 3BIL_A 171 GIAAAVELLAHNNALPIGYLSGPMDTSTGRERLEDFKAACANS-KIGEQLVFLGG--YEQSVGFEGATKLLD-QGAKTLF 246 (348) T ss_dssp HHHHHHHHHHHTTCCSEEEECCCTTSHHHHHHHHHHHHHHHHT-TCCCCEEECCC--SSHHHHHHHHHHHHH-TTCSEEE T ss_pred HHHHHHHHHHhCCCCcEEEEeCCCCChhHHHHHHHHHHHHHhC-CCCcceEEecC--CChHhHHHHHHHHHh-cCCCEEE Confidence 677777777666788999998543 35667788888888764 34332211111 112233445556653 4688877 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|.. T Consensus 247 ~~~-d~~a~~~~~~l~~~g~~ 266 (348) T 3BIL_A 247 AGD-SMMTIGVIEACHKAGLV 266 (348) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred ECC-HHHHHHHHHHHHHCCCC Confidence 663 44566778888877763 No 171 >3O74_A Fructose transport system repressor FruR; Dual transcriptional regulator, DNA, Transcription; HET: MSE, GOL; 2.0A {Pseudomonas putida} Probab=97.35 E-value=2.3e-07 Score=91.89 Aligned_cols=200 Identities=8% Similarity=0.042 Sum_probs=117.4 Template_Neff=12.400 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ ++ +.+.+...+.. ...+..+.+. T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~--~~~~~~~~~~~----~~~~~~~~~~ 55 (272) T 3O74_A 2 TRTLGFILPDLEN------------PSYARIAKQLEQGARARG--------YQ--LLIASSDDQPD----SERQLQQLFR 55 (272) T ss_dssp CCEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT--------CE--EEEEECTTCHH----HHHHHHHHHH T ss_pred CceEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------cE--EEEEeCCCChh----HHHHHHHHHH Confidence 5789999987542 255677788888877652 33 33334322211 1112222221 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|+...+.........+...++|+|..+...+. +.++.+..++...+. T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~v~~d~~~~~~ 109 (272) T 3O74_A 56 A-------------------RRCDALFVASCLPPEDDSYRELQDKGLPVIAIDRRLDP-------AHFCSVISDDRDASR 109 (272) T ss_dssp H-------------------TTCSEEEECCCCCSSCCHHHHHHHTTCCEEEESSCCCT-------TTCEEEEECHHHHHH T ss_pred H-------------------cCCCEEEEecCCCCchHHHHHHHHCCCCEEEECCCCCC-------CCCcEEEeCcHHHHH Confidence 1 47888887654433334455667789999987764331 345667777777777 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET--PNARAVIM 280 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~~viv~ 280 (908) .+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+....... .+..+....++++++. .++|++++ T Consensus 110 ~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~d~v~~ 186 (272) T 3O74_A 110 QLAASLLSSAPRSIALIGARPELSVSQARAGGFDEALQGY-TGEVRRYQGEA--FSRECGQRLMQQLIDDLGGLPDALVT 186 (272) T ss_dssp HHHHHHHTTCCSEEEEEEECTTSHHHHHHHHHHHHHTTTC-CSEEEEEEESS--SSHHHHHHHHHHHHHHHTSCCSEEEE T ss_pred HHHHHHHHhCCCEEEEEEcCCCChHHHHHHHHHHHHHHhc-CCeeeEEeccc--CCHHHHHHHHHHHHHHhCCCCCEEEE Confidence 8888876668889999985433 5667788888888765 34433211111 1112334445555421 35778776 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 187 ~~-~~~a~~~~~~l~~~g~~ 205 (272) T 3O74_A 187 TS-YVLLQGVFDTLQARPVD 205 (272) T ss_dssp SS-HHHHHHHHHHHHTSCGG T ss_pred cC-HHHHHHHHHHHHhCCCC Confidence 64 33466777788777764 No 172 >3O74_B Fructose transport system repressor FruR; Dual transcriptional regulator, DNA, Transcription; HET: GOL; 2.0A {Pseudomonas putida} Probab=97.35 E-value=2.3e-07 Score=91.89 Aligned_cols=200 Identities=8% Similarity=0.042 Sum_probs=117.4 Template_Neff=12.400 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ ++ +.+.+...+.. ...+..+.+. T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~--~~~~~~~~~~~----~~~~~~~~~~ 55 (272) T 3O74_B 2 TRTLGFILPDLEN------------PSYARIAKQLEQGARARG--------YQ--LLIASSDDQPD----SERQLQQLFR 55 (272) T ss_dssp CSEEEEEESCTTC------------HHHHHHHHHHHHHHHHTT--------CE--EEEEECTTCHH----HHHHHHHHHH T ss_pred CceEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------cE--EEEEeCCCChh----HHHHHHHHHH Confidence 5789999987542 255677788888877652 33 33334322211 1112222221 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . ++++++|+...+.........+...++|+|..+...+. +.++.+..++...+. T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~v~~d~~~~~~ 109 (272) T 3O74_B 56 A-------------------RRCDALFVASCLPPEDDSYRELQDKGLPVIAIDRRLDP-------AHFCSVISDDRDASR 109 (272) T ss_dssp H-------------------TTCSEEEECCCSCTTCCHHHHHHHTTCCEEEESSCCCT-------TTCEEEEECHHHHHH T ss_pred H-------------------cCCCEEEEecCCCCchHHHHHHHHCCCCEEEECCCCCC-------CCCcEEEeCcHHHHH Confidence 1 47888887654433334455667789999987764331 345667777777777 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET--PNARAVIM 280 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~~viv~ 280 (908) .+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+....... .+..+....++++++. .++|++++ T Consensus 110 ~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~d~v~~ 186 (272) T 3O74_B 110 QLAASLLSSAPRSIALIGARPELSVSQARAGGFDEALQGY-TGEVRRYQGEA--FSRECGQRLMQQLIDDLGGLPDALVT 186 (272) T ss_dssp HHHHHHHTTCCSEEEEEEECTTSHHHHHHHHHHHHTTTTC-CSEEEEEEESS--SSHHHHHHHHHHHHHHHTSCCSEEEE T ss_pred HHHHHHHHhCCCEEEEEEcCCCChHHHHHHHHHHHHHHhc-CCeeeEEeccc--CCHHHHHHHHHHHHHHhCCCCCEEEE Confidence 8888876668889999985433 5667788888888765 34433211111 1112334445555421 35778776 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 187 ~~-~~~a~~~~~~l~~~g~~ 205 (272) T 3O74_B 187 TS-YVLLQGVFDTLQARPVD 205 (272) T ss_dssp SS-HHHHHHHHHHHHHSCTT T ss_pred cC-HHHHHHHHHHHHhCCCC Confidence 64 33466777788777764 No 173 >4Z0N_A Periplasmic Solute Binding Protein; Periplasmic solute binding Protein, ENZYME; HET: GAL, SO4, EDO, MSE; 1.26A {Streptobacillus moniliformis} Probab=97.34 E-value=2.3e-07 Score=95.62 Aligned_cols=222 Identities=13% Similarity=0.038 Sum_probs=123.0 Template_Neff=11.400 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++..+..+++.++++. |+++++...|+..++. ...+. T Consensus 26 ~~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~v~~~~~d~~~~~~----~~~~~ 81 (337) T 4Z0N_A 26 KKDTSKITLGVTYYKFDD------------NFLAGMRNDMIQIAKEK--------YPNIELLNNDSQNSQS----ILNDQ 81 (337) T ss_dssp -----CEEEEEEESCTTC------------HHHHHHHHHHHHHHHHH--------CTTEEEEEEECTTCHH----HHHHH T ss_pred CCCCCCeEEEEEEccCCC------------HHHHHHHHHHHHHHHHH--------CCCeEEEeCCCCCCHH----HHHHH Confidence 345568999999986542 25567778888887775 3445666555443322 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+... ......+...++|+|..+...+..... ..++++++.++ T Consensus 82 i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~-~~~~~~~v~~d 141 (337) T 4Z0N_A 82 IEVLIN-------------------KGVNVLVINLVDPTAGQSVIDKAKAANIPIILFNKDPGVDALN-SYDKAWYVGTT 141 (337) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTCHHHHHHHHHHHTCCEEEESSCCCHHHHT-TCTTEEEEECC T ss_pred HHHHHH-------------------cCCCEEEEecCCccchHHHHHHHHHCCCCEEEEccCCCCcccc-ccccceEEecC Confidence 444332 478887765433322 244556677899999887654321110 13456677777 Q NP_000836.2 199 DSYQAQAMVDIVTA------------LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEK 264 (908) Q Consensus 199 ~~~~~~~~~~~l~~------------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~ 264 (908) ....++.+++++.+ .+.++++++.. ++.+...+.+++++.+++. ++.+..........+..+... T Consensus 142 ~~~~~~~~~~~l~~~~~~~~~~~~~~~g~~~v~~l~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~~~~~~~~~~~~~~ 220 (337) T 4Z0N_A 142 PKDSGILQGQVIEKAWLANPAYDLNGDGVIQYVMLFGEPGQPDAEARTKYSIEYLNEK-GIKTEELHKDIANWDAAQAKD 220 (337) T ss_dssp HHHHHHHHHHHHHHHHHHCGGGCTTCSSSEEEEEEECCTTCHHHHHHHHHHHHHHHHT-TCCEEEEEEEECTTCHHHHHH T ss_pred chHHHHHHHHHHHHHHhcCCccccCCCCeeEEEEEECCCCCcCHHHHHHHHHHHHHhc-CCCceeecccccCCCHHHHHH Confidence 77777777776643 35678998875 3455667778888887764 343321100100011123344 Q NP_000836.2 265 IIKRLLET---PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 265 ~~~~l~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) .++++++. .++++|+... +..+..+++++++.|. ++.+++.+ T Consensus 221 ~~~~~l~~~~~~~~~~i~~~~-~~~a~~~~~~~~~~g~--~v~vi~~d 265 (337) T 4Z0N_A 221 KMDAWLSGPNANKIEVVIANN-DGMALGAVESIKAVKK--ELPVFGVD 265 (337) T ss_dssp HHHHHHHSTTGGGCCEEEESS-HHHHHHHHHHHHHTTC--CCCEECSB T ss_pred HHHHHHcCCCCCCccEEEECC-hHHHHHHHHHHHHcCC--CCCEEEec Confidence 55555431 2356666553 4455667777777663 34444443 No 174 >4PE6_B solute binding protein; Structural Genomics, PSI-Biology, Midwest Center; HET: MSE, LTH; 1.86A {Thermobispora bispora} Probab=97.34 E-value=2.3e-07 Score=95.76 Aligned_cols=210 Identities=10% Similarity=-0.060 Sum_probs=116.5 Template_Neff=10.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|.... .++.....+++.++++.|..++. +++.+...|+..++. ...+. T Consensus 13 ~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~~~~gg~---~~~~~~~~d~~~~~~----~~~~~ 73 (341) T 4PE6_B 13 QAEGDKPFIALSNGFIGN------------GWRQTMIAKFEEAAKQAQADGLI---GKYKVVNAPGNNSAT----EQVAQ 73 (341) T ss_dssp -----CCEEEEEESCCSS------------HHHHHHHHHHHHHHHHHHHTTSC---SEEEEEECCTTTCHH----HHHHH T ss_pred HHhCCCCEEEEEccccCC------------HHHHHHHHHHHHHHHHhcccCCc---ceEEEEeCCCCCCHH----HHHHH Confidence 455678999999986322 35677889999999998865432 345555555443322 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++++|+.. .+.........+...++|+|..+...+. ++.+....+ T Consensus 74 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-------~~~~~~~~~ 127 (341) T 4PE6_B 74 IKSLLL-------------------QKPDALLINPASPTALQPVIQQACDAGVKVVVFDSAIDA-------PCAYILQNS 127 (341) T ss_dssp HHHHHT-------------------TCCSEEEEECSSSSTTHHHHHHHHHTTCEEEEESSCCCC-------TTSEEEEEC T ss_pred HHHHHh-------------------cCCCEEEECCCChhhhHHHHHHHHHCCCEEEEeCCCCCC-------CCcEEeeCC Confidence 444332 4778777643 3322234445566789999987764331 233444444 Q NP_000836.2 199 DSYQAQAMVDIVTALG--WNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-P 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~--~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~ 273 (908) ....++.+++++.+.+ .++++++.. ++.++..+.++|++.+++..++++....... .+..+....++++++. . T Consensus 128 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 205 (341) T 4PE6_B 128 FVDWATYAAKPVLESIGGKGNVIVVRGVVGSQPEAEMYETTKKILAEYPQVKTVATVTGM--CDGATAQKAVLGVLPSVS 205 (341) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEEECSTTSHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHGGGSC T ss_pred HHHHHHHHHHHHHHHhCCCeeEEEEecCCCChHHHHHHHHHHHHHHhCCCceEEEEEeCC--CCHHHHHHHHHHhHhhCC Confidence 4455667777765443 678998885 3455667788888887753124443221111 1122344455555431 2 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++++|++.. + . ..+++++++.|. T Consensus 206 ~~~~i~~~~-d-~-~~~~~al~~~g~ 228 (341) T 4PE6_B 206 TVDAVIGCG-D-G-YGVAQAFATAGK 228 (341) T ss_dssp CCCEEECSS-C-H-HHHHHHHHHHTC T ss_pred CCCEEEEcC-c-H-HHHHHHHHHCCC Confidence 355555543 2 2 567777777765 No 175 >2X7X_A SENSOR PROTEIN (E.C.2.7.13.3); TRANSFERASE, SENSOR HISTIDINE KINASE; HET: PO4, FRU; 2.64A {BACTEROIDES THETAIOTAOMICRON} Probab=97.34 E-value=2.4e-07 Score=94.96 Aligned_cols=213 Identities=11% Similarity=0.088 Sum_probs=118.4 Template_Neff=11.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++++||++.|.+. .++.....+++.++.+.+ | +++.+.|+..++. ...+.++ T Consensus 3 ~~~~~~Ig~v~~~~~-------------~~~~~~~~g~~~~~~~~~-------g--i~l~~~~~~~~~~----~~~~~~~ 56 (325) T 2X7X_A 3 DTPHFRIGVAQCSDD-------------SWRHKMNDEILREAMFYN-------G--VSVEIRSAGDDNS----KQAEDVH 56 (325) T ss_dssp ---CCEEEEEESCCS-------------HHHHHHHHHHHHHHTTSS-------S--CEEEEEECTTCHH----HHHHHHH T ss_pred CCCCeEEEEEECCCC-------------HHHHHHHHHHHHHHHHhC-------C--eEEEEEECCCCHH----HHHHHHH Confidence 356789999998732 244455666665443321 2 3445555543322 2223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.+++. T Consensus 57 ~l~~-------------------~~vd~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 111 (325) T 2X7X_A 57 YFMD-------------------EGVDLLIISANEAAPMTPIVEEAYQKGIPVILVDRKILS------DKYTAYIGADNY 111 (325) T ss_dssp HHHH-------------------TTCSEEEECCSSHHHHHHHHHHHHHTTCCEEEESSCCSS------SCSSEEEEECHH T ss_pred HHHH-------------------cCCCEEEEcCCCCCCcHHHHHHHHHCCCCEEEECCCCCC------CCccEEEEcCHH Confidence 3332 478887765444332 23445566789999987654321 245677888877 Q NP_000836.2 201 YQAQAMVDIVTA--LGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 201 ~~~~~~~~~l~~--~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ..++.+++++.+ .+.++++++.... .++..+.+++++.+++.+++++....... .+..+....+++++. ..++ T Consensus 112 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~ 189 (325) T 2X7X_A 112 EIGRSVGNYIASSLKGKGNIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAA--WERGPAEIEMDSMLRRHPKI 189 (325) T ss_dssp HHHHHHHHHHHHHTTTEEEEEEEESCTTSHHHHHHHHHHHHHHHTCTEEEEEEEEECT--TSHHHHHHHHHHHHHHCSCC T ss_pred HHHHHHHHHHHHHcCCCeEEEEEEcCCCChHHHHHHHHHHHHHhcCCCcEEEEEeeCC--CCccHHHHHHHHHHHhCCCC Confidence 778888888765 5778999998533 35566777888777654223332211111 111233344455542 1256 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 ~~i~~~~-~~~a~~~~~al~~~g~~~~v~ii~~ 221 (325) T 2X7X_A 190 DAVYAHN-DRIAPGAYQAAKMAGREKEMIFVGI 221 (325) T ss_dssp CEEEESS-TTHHHHHHHHHHHTTCTTSSEEEEE T ss_pred CEEEECC-hhHHHHHHHHHHHcCCCCCCEEEEE Confidence 7776654 3456677788887776323444443 No 176 >2X7X_B SENSOR PROTEIN (E.C.2.7.13.3); TRANSFERASE, SENSOR HISTIDINE KINASE; HET: FRU, PO4; 2.64A {BACTEROIDES THETAIOTAOMICRON} Probab=97.34 E-value=2.4e-07 Score=94.96 Aligned_cols=213 Identities=11% Similarity=0.088 Sum_probs=118.4 Template_Neff=11.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++++||++.|.+. .++.....+++.++.+.+ | +++.+.|+..++. ...+.++ T Consensus 3 ~~~~~~Ig~v~~~~~-------------~~~~~~~~g~~~~~~~~~-------g--i~l~~~~~~~~~~----~~~~~~~ 56 (325) T 2X7X_B 3 DTPHFRIGVAQCSDD-------------SWRHKMNDEILREAMFYN-------G--VSVEIRSAGDDNS----KQAEDVH 56 (325) T ss_dssp ---CEEEEEEESCCS-------------HHHHHHHHHHHHHHTTST-------T--EEEEEEECTTCHH----HHHHHHH T ss_pred CCCCeEEEEEECCCC-------------HHHHHHHHHHHHHHHHhC-------C--eEEEEEECCCCHH----HHHHHHH Confidence 356789999998732 244455666665443321 2 3445555543322 2223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.+++. T Consensus 57 ~l~~-------------------~~vd~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 111 (325) T 2X7X_B 57 YFMD-------------------EGVDLLIISANEAAPMTPIVEEAYQKGIPVILVDRKILS------DKYTAYIGADNY 111 (325) T ss_dssp HHHH-------------------TTCSEEEECCSSHHHHHHHHHHHHHTTCCEEEESSCCSS------SCSSEEEEECHH T ss_pred HHHH-------------------cCCCEEEEcCCCCCCcHHHHHHHHHCCCCEEEECCCCCC------CCccEEEEcCHH Confidence 3332 478887765444332 23445566789999987654321 245677888877 Q NP_000836.2 201 YQAQAMVDIVTA--LGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 201 ~~~~~~~~~l~~--~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ..++.+++++.+ .+.++++++.... .++..+.+++++.+++.+++++....... .+..+....+++++. ..++ T Consensus 112 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~ 189 (325) T 2X7X_B 112 EIGRSVGNYIASSLKGKGNIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAA--WERGPAEIEMDSMLRRHPKI 189 (325) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEEESCTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TSHHHHHHHHHHHHHHCSCC T ss_pred HHHHHHHHHHHHHcCCCeEEEEEEcCCCChHHHHHHHHHHHHHhcCCCcEEEEEeeCC--CCccHHHHHHHHHHHhCCCC Confidence 778888888765 5778999998533 35566777888777654223332211111 111233344455542 1256 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 ~~i~~~~-~~~a~~~~~al~~~g~~~~v~ii~~ 221 (325) T 2X7X_B 190 DAVYAHN-DRIAPGAYQAAKMAGREKEMIFVGI 221 (325) T ss_dssp CEEEESS-TTHHHHHHHHHHHTTCGGGSEEEEE T ss_pred CEEEECC-hhHHHHHHHHHHHcCCCCCCEEEEE Confidence 7776654 3456677788887776323444443 No 177 >4RXM_A Possible sugar ABC superfamily ATP; TRANSPORTER, ABC-TYPE, ENZYME FUNCTION INITIATIVE; HET: BGC, INS; 1.75A {Mannheimia haemolytica} Probab=97.33 E-value=2.4e-07 Score=92.94 Aligned_cols=205 Identities=12% Similarity=0.043 Sum_probs=117.4 Template_Neff=12.100 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|..+. .++.....+++.++++.+ +++.+.|...++. ...+.+++ T Consensus 2 ~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~a~~~~~----------~~~~~~~~~~~~~----~~~~~~~~ 55 (292) T 4RXM_A 2 MKDELVVFSLPNLSS------------PFEVQLQKVAVETSKKLE----------IKLQVLDGQSSST----KQASDLEN 55 (292) T ss_dssp CCCCEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHH T ss_pred CcccEEEEecCCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEcCCCCHH----HHHHHHHH Confidence 357899999997542 255677788888877642 3445555543322 22233343 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+... ......+...++|+|..+...+. .++++++.+++.. T Consensus 56 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~ 110 (292) T 4RXM_A 56 AIT-------------------RGAKGIIISPNDVNAISGAVEEIIKEKIPAATLDRKVES------SKPVPHFGANNYT 110 (292) T ss_dssp HHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCC------SSCCCEEEECHHH T ss_pred HHh-------------------cCCCEEEEecCCHhhHHHHHHHHHHCCCCEEEeCCCCCC------CCCccEEecCchH Confidence 332 477877764433322 24445566789999987764321 2356677777777 Q NP_000836.2 202 QAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE--TPNA 275 (908) Q Consensus 202 ~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~--~~~~ 275 (908) .++.+++++.+. +.++++++.. +..++..+.+++++.+++. +..+........+.+..+....+.++++ ..++ T Consensus 111 ~~~~~~~~l~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 189 (292) T 4RXM_A 111 GGQEVAKAVKAKYPNGAKIILLTGQPGSTSNIERTKGIRDELAAG-GDKYKIVVDQTGNWLRSEGLRIIESVLPTLKEKP 189 (292) T ss_dssp HHHHHHHHHHHHSTTCEEEEEEECCTTCHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHGGGCSSCC T ss_pred HHHHHHHHHHHHCCCCCeEEEEECCCCChhHHHHHHHHHHHHHhC-CCceEEEEeecCCCCHHHHHHHHHHHHHHcCCCC Confidence 788888887543 5668888775 3445667788888888764 3332211111100111122233334331 1357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |+|++.. +..+..+++++++.|.. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~ 213 (292) T 4RXM_A 190 EVIISAN-DDMALGAIEALRSQGLK 213 (292) T ss_dssp SEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCC Confidence 8865543 44566778888877763 No 178 >2HSG_A Glucose-resistance amylase regulator; CCPA, TRANSCRIPTIONAL REGULATOR, TRANSCRIPTION REGULATOR; 2.5A {Bacillus megaterium} SCOP: a.35.1.5, c.93.1.1 Probab=97.33 E-value=2.5e-07 Score=95.08 Aligned_cols=204 Identities=11% Similarity=0.117 Sum_probs=120.7 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ +++.+.|...++ ....+.++ T Consensus 57 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 110 (332) T 2HSG_A 57 SKKTTTVGVIIPDISN------------IFYAELARGIEDIATMYK----------YNIILSNSDQNQ----DKELHLLN 110 (332) T ss_pred cCCCCEEEEEeCCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHHHHHH Confidence 4568899999987542 245667778888777642 233444543332 12233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. +++|++|+...+. .......+...++|+|.++...+ .+..+.+.+++.. T Consensus 111 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~~~~~ 163 (332) T 2HSG_A 111 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 163 (332) T ss_pred HHHH-------------------cCCCEEEECCCCC-CHHHHHHHHHcCCCEEEeCCCCC-------CCCCcEEEEChHH Confidence 4332 4788888754443 23444556678999998765322 2345566677767 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .+..+++++.+.+.++++++..+.. ++..+.++|++.+++. ++.+.....+..+.+..+....+++++. ..++|+ T Consensus 164 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 242 (332) T 2HSG_A 164 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 242 (332) T ss_pred HHHHHHHHHHHCCCCcEEEEeCCcccChhHHHHHHHHHHHHHHC-CCCCCHHHcccCCCCHHHHHHHHHHHHHcCCCCCE Confidence 7777888876668889999985433 4567788888888764 3443321111110112233444555542 136788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 243 i~~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 2HSG_A 243 IFVGT-DEMALGVIHGAQDRGLN 264 (332) T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 87664 44566778888887763 No 179 >1ZHH_A Autoinducer 2-binding periplasmic protein luxP; PERIPLASMIC BINDING PROTEIN, PER/ARNT/SIMPLE-MINDED (PAS); HET: NHE; 1.94A {Vibrio harveyi} SCOP: c.93.1.1 Probab=97.33 E-value=2.5e-07 Score=95.67 Aligned_cols=220 Identities=11% Similarity=0.031 Sum_probs=124.3 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGV--RILDTCSRDTYALEQSLTF 119 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~--~~~d~~~~~~~a~~~~~~~ 119 (908) ..+.++||++.|..+.. .+......+++.++++.+ +++++ .+.|+..++. ...+. T Consensus 42 ~~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~~~~~~g--------~~~~l~~~~~d~~~~~~----~~~~~ 98 (344) T 1ZHH_A 42 TQRPIKISVVYPGQQVS-----------DYWVRNIASFEKRLYKLN--------INYQLNQVFTRPNADIK----QQSLS 98 (344) T ss_dssp CSSCEEEEEEEESSCSS-----------CHHHHHHHHHHHHHHHTT--------CCEEEEEEEECTTSCHH----HHHHH T ss_pred CCCCeEEEEEeCCCCCC-----------HHHHHHHHHHHHHHHHcC--------CcEEEEEeecCCCCCHH----HHHHH Confidence 56789999999975321 233467788888888764 23333 4455444422 23333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.........+.. .++|+|..+...+.... ...++++++.++ T Consensus 99 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d 158 (344) T 1ZHH_A 99 LMEALK-------------------SKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREW-DKHQPFLYVGFD 158 (344) T ss_dssp THHHHH-------------------TTCSEEEECSCTTTTHHHHHHHHHHCSSEEEEESCCSCBGGG-TTSCCSEEEECC T ss_pred HHHHHh-------------------cCCCEEEEeCCchHhHHHHHHHHHhCCCeEEEEeCCCCchhh-ccCCCeEEEEec Confidence 444332 478888876543333333444444 79999987654432111 113567777788 Q NP_000836.2 199 DSYQAQAMVDIVTALGWN--YVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PN 274 (908) Q Consensus 199 ~~~~~~~~~~~l~~~~~~--~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~ 274 (908) +...++.+++++.+.+.+ +++++..+ +.++..+.++|++.+++.+++.+....... .+..+....++++++. .+ T Consensus 159 ~~~~~~~~~~~l~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~ 236 (344) T 1ZHH_A 159 HAEGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTK--ATKQSGYDAAKASLAKHPD 236 (344) T ss_dssp HHHHHHHHHHHHHHHSCTTCEEEEECCSTTHHCCCCCCHHHHHHHHHHCCEEEEEECCC--SSHHHHHHHHHHHHHHCCC T ss_pred cHHHHHHHHHHHHHhCCCCceEEEEEcCCCchHHHHHHHHHHHHHhCCCcEEEEeeecC--CCHHHHHHHHHHHHHHCCC Confidence 777788888887654443 48888754 456667778888877754224433211111 1222344555555431 23 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +++|+.. ++..+..+++++++.|. .++.+++. T Consensus 237 ~~~i~~~-~~~~a~~~~~~l~~~g~-~~~~v~~~ 268 (344) T 1ZHH_A 237 VDFIYAC-STDVALGAVDALAELGR-EDIMINGW 268 (344) T ss_dssp CSEEEES-SHHHHHHHHHHHHHHTC-TTSEEBCS T ss_pred ccEEEEC-ChHHHHHHHHHHHHcCC-CCcEEEEe Confidence 4555544 34455668888888776 23344443 No 180 >5ULB_A Putative sugar ABC transporter; ABC transporter, Methylthioribose-binding protein, Structural; HET: MSE, 8GG, 8GA; 1.28A {Yersinia enterocolitica subsp. enterocolitica 8081} Probab=97.32 E-value=2.6e-07 Score=95.13 Aligned_cols=217 Identities=12% Similarity=0.087 Sum_probs=123.7 Template_Neff=11.700 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+.++||++.|..+. .++..+..+++.++++.| +++.+.|+..+. +... T Consensus 12 ~~~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~ 65 (337) T 5ULB_A 12 AIAKHQGQIKIAVIRNLGSD------------DNTTQFLSGVLKEGKKLG----------FKVDTFLSNGDD----ARFQ 65 (337) T ss_dssp HHHTCSSCCEEEEEESSCSC------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHH T ss_pred HHHhccCCcEEEEEEeCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHH Confidence 34566788999999997653 245677788888887753 334445544332 1223 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAA-SSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~-s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .+++++|+... +.........+...++|+|..+...+. ..++++++. T Consensus 66 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~~~ 121 (337) T 5ULB_A 66 DFVNQAIS-------------------QKYDGIILSQGRDPYSTELVKRIVANGIAVSVFDTAIQG-----DIPGLTVTQ 121 (337) T ss_dssp HHHHHHHH-------------------TTCSEEEEESCCTTTHHHHHHHHHHTTCEEEEESCCCCS-----CCTTCEEEE T ss_pred HHHHHHHh-------------------CCCCEEEEcCCCCccCHHHHHHHHHCCCeEEEEccCCCC-----CCCCeEEEe Confidence 33444332 47888776543 222234445566789999987654331 124556666 Q NP_000836.2 197 PPDSYQAQAMVDIVTA--LGWNYVSTLA-SEGNYGESGVEAFTQISREIGGVCIAQSQK--IPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~--~~~~~v~ii~-~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~--~~~~~~~~~~~~~~~~l~~ 271 (908) +++...+..+++++.+ .+.++++++. .+..++..+.++|++.+++.+++.+..... +. ....+....+++++. T Consensus 122 ~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 199 (337) T 5ULB_A 122 QDDASLTNESFGQLVKDFNGKANIIKLWVAGFPPMERRQAAYQALLKQNPGITELESIGAVSS--DVQGDTANKVGAVLA 199 (337) T ss_dssp ECHHHHHHHHHHHHHHHTTTCEEEEEECCTTSHHHHHHHHHHHHHHHHCTTEEEEEEECCCCT--THHHHHHHHHHHHHH T ss_pred cCchHHHHHHHHHHHHhhCCCccEEEEEcCCChhHHHHHHHHHHHHHhCCCcEEEEEEccCCC--CCCcchHHHHHHHHH Confidence 6666566666666544 4678899884 334556677788888777642244332111 11 111123344555542 Q NP_000836.2 272 T-P--NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~-~--~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) . . ++++|++.. +..+..+++++++.|+. ++.+++. T Consensus 200 ~~~~~~~~~i~~~~-~~~a~~~~~al~~~g~~-~i~v~~~ 237 (337) T 5ULB_A 200 KYPKGKIDAIWGTW-DAFTQGAYKALQENGRT-EIKLYSI 237 (337) T ss_dssp HSCTTSCCEEEESS-HHHHHHHHHHHHHTTCT-TSEEEEE T ss_pred hCCCCCeeEEEECC-chHHHHHHHHHHHcCCC-CCEEEEE Confidence 1 1 347776664 44466788888887762 3444443 No 181 >2FEP_A Catabolite control protein A, Phosphocarrier; CcpA, HPr, transcriptional regulator, TRANSCRIPTION; HET: SO4; 2.45A {Bacillus subtilis} Probab=97.32 E-value=2.7e-07 Score=92.60 Aligned_cols=206 Identities=9% Similarity=0.056 Sum_probs=118.1 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+..+||++.|..+. .++.....+++.++++.+ +++ .+.+...++ ....+. T Consensus 11 ~~~~~~~~igvi~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~--~~~~~~~~~----~~~~~~ 64 (289) T 2FEP_A 11 GSSKKTTTVGVIIPDISS------------IFYSELARGIEDIATMYK--------YNI--ILSNSDQNM----EKELHL 64 (289) T ss_dssp -----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------CEE--EEEECTTCH----HHHHHH T ss_pred CCCCCccEEEEEeCCCCc------------HHHHHHHHHHHHHHHHcC--------CcE--EEEeCCCCH----HHHHHH Confidence 345678899999987542 255677788887777642 333 334433332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++++. ++++++|+...+.. ......+...++|+|..+...+ .+..+.+..++ T Consensus 65 ~~~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~ 117 (289) T 2FEP_A 65 LNTMLG-------------------KQVDGIVFMGGNIT-DEHVAEFKRSPVPIVLAASVEE-------QEETPSVAIDY 117 (289) T ss_dssp HHHHHH-------------------TTCSEEEECCSCCC-HHHHHHHHHSSSCEEEESCCCT-------TCCSCEEECCH T ss_pred HHHHhc-------------------CCCCEEEEeCCCCC-HHHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEeCH Confidence 443332 47888887554433 3444556678999998765432 13455666777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGNYG---ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~~~---~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ...++.+++++.+.+.++++++..+..++ ..+.+++++.+++. ++.+........+.+..+....++++++ ..++ T Consensus 118 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 196 (289) T 2FEP_A 118 EQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEA-NLPFNEQFVAEGDYTYDSGLEALQHLMSLDKKP 196 (289) T ss_dssp HHHHHHHHHHHHHTTCSSEEEEESCTTSHCCCCCCHHHHHHHHHHT-TCCCCGGGEEECCSCHHHHHHHHHHHTTSSSCC T ss_pred HHHHHHHHHHHHHCCCCcEEEEeCCCCCCccHHHHHHHHHHHHHHC-CCCCCHHHhccCCCCcchHHHHHHHHHhcCCCC Confidence 77777888887666888999998654433 56677888877764 2332211111100111233344555542 1367 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |+|++.. +..+..+++++++.|+. T Consensus 197 d~i~~~~-~~~~~~~~~~l~~~g~~ 220 (289) T 2FEP_A 197 TAILSAT-DEMALGIIHAAQDQGLS 220 (289) T ss_dssp SEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CEEEECC-cHHHHHHHHHHHHCCCC Confidence 8887664 44567778888877764 No 182 >2IKS_A DNA-binding transcriptional dual regulator; DNA-binding transcriptional dual regulator, Escherichia; 1.85A {Escherichia coli} Probab=97.31 E-value=2.7e-07 Score=92.64 Aligned_cols=204 Identities=11% Similarity=0.090 Sum_probs=117.9 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++.....+++.++++.+ +++.+.+...+. +...+.+ T Consensus 16 ~~~~~~~Ig~~~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 69 (293) T 2IKS_A 16 RAGRTRSIGLVIPDLEN------------TSYTRIANYLERQARQRG----------YQLLIACSEDQP----DNEMRCI 69 (293) T ss_dssp --CCCCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred hcCCCCEEEEEecCCCC------------hHHHHHHHHHHHHHHHcC----------CeEEEEeCCCCH----HHHHHHH Confidence 44578999999987542 245667778887777642 233344443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. ++++++|+...+.........+...++|+|..+...+. +..+.+..++. T Consensus 70 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~~~~~~~ 123 (293) T 2IKS_A 70 EHLLQ-------------------RQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDR-------EHFTSVVGADQ 123 (293) T ss_dssp HHHHH-------------------TTCSEEEECCSSCTTCHHHHTTTTSSSCEEEEESCCCT-------TTCEEEEECHH T ss_pred HHHHh-------------------CCCCEEEECCCCCCCchHHHHHHcCCCCEEEEcCCcCc-------ccCcEEEeCcH Confidence 43332 47888887554433333445566789999987764331 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..+..+++++.+.+.++++++.. +..+...+.++|++.+++. ++.+....... .+..+....++++++. .++|+ T Consensus 124 ~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~ 200 (293) T 2IKS_A 124 DDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDD-PREVHFLYANS--YEREAAAQLFEKWLETHPMPQA 200 (293) T ss_dssp HHHHHHHHHHHTSCCSSEEEEEECTTSHHHHHHHHHHHHHHTTC-CCCEEEEEESS--SCHHHHHHHHHHHTTTSCCCSE T ss_pred HHHHHHHHHHHhCCCcEEEEEeCCccchhHHHHHHHHHHHHHhC-CCceeeeecCC--CCHHHHHHHHHHHHHhCCCCCE Confidence 66777788776667889999985 3345666778888887764 34433211111 1112233445555421 24777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++.+.|.. T Consensus 201 i~~~~-~~~a~~~~~~~~~~~~~ 222 (293) T 2IKS_A 201 LFTTS-FALLQGVMDVTLRRDGK 222 (293) T ss_dssp EEESS-HHHHHHHHHHHHHHHSS T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77654 44456677777776653 No 183 >3D8U_A PurR transcriptional regulator; APC91343.1, PurR, transcriptional regulator, Vibrio; HET: MSE; 2.88A {Vibrio parahaemolyticus} Probab=97.31 E-value=2.7e-07 Score=91.46 Aligned_cols=202 Identities=12% Similarity=0.082 Sum_probs=116.7 Template_Neff=12.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||++.|.... .++..+..+++.++++.+ +++.+.++..++ +...+.++++ T Consensus 2 ~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~~ 55 (275) T 3D8U_A 2 NAYSIALIIPSLFE------------KACAHFLPSFQQALNKAG----------YQLLLGYSDYSI----EQEEKLLSTF 55 (275) T ss_dssp --CEEEEEESCSSC------------HHHHHHHHHHHHHHHHTS----------CEECCEECTTCH----HHHHHHHHHH T ss_pred CcceEEEEeCccCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHHHH Confidence 46889999987532 245667778887777642 233444443332 1223334433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. .+++++|+...+... .....+...++|+|..+...+ .++.+.+..+....+ T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~~~ 108 (275) T 3D8U_A 56 LE-------------------SRPAGVVLFGSEHSQ-RTHQLLEASNTPVLEIAELSS-------KASYLNIGVDHFEVG 108 (275) T ss_dssp HT-------------------SCCCCEEEESSCCCH-HHHHHHHHHTCCEEEESSSCS-------SSSSEEECBCHHHHH T ss_pred HH-------------------hCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCcEEEeCHHHHH Confidence 32 478888875544333 344556678999988765432 134566677777777 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVIM 280 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv~ 280 (908) +.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....++++++ ..++|+|++ T Consensus 109 ~~~~~~l~~~g~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~i~~ 187 (275) T 3D8U_A 109 KACTRHLIEQGFKNVGFIGARGNHSTLQRQLHGWQSAMIEN-YLTPDHFLTTHEAPSSQLGAEGLAKLLLRDSSLNALVC 187 (275) T ss_dssp HHHHHHHHTTTCCCEEEEECSCSSHHHHHHHHHHHHHHHHT-TCCCCCEEECSSCCCHHHHHHHHHHHHTTCTTCCEEEE T ss_pred HHHHHHHHHCCCCcEEEEecCCCchHHHHHHHHHHHHHHHC-CCCcceEEecCCCCchhhHHHHHHHHHhcCCCCCEEEE Confidence 78888876668889999985443 4556777888877764 3433211111100111223344555542 134788876 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 188 ~~-~~~~~~~~~~~~~~g~~ 206 (275) T 3D8U_A 188 SH-EEIAIGALFECHRRVLK 206 (275) T ss_dssp SS-HHHHHHHHHHHHHTTCC T ss_pred CC-HHHHHHHHHHHHHCCCC Confidence 64 35566778888877763 No 184 >3D8U_B PurR transcriptional regulator; APC91343.1, PurR, transcriptional regulator, Vibrio; 2.88A {Vibrio parahaemolyticus} Probab=97.31 E-value=2.7e-07 Score=91.46 Aligned_cols=202 Identities=12% Similarity=0.082 Sum_probs=116.7 Template_Neff=12.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ++++||++.|.... .++..+..+++.++++.+ +++.+.++..++ +...+.++++ T Consensus 2 ~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~~ 55 (275) T 3D8U_B 2 NAYSIALIIPSLFE------------KACAHFLPSFQQALNKAG----------YQLLLGYSDYSI----EQEEKLLSTF 55 (275) T ss_dssp --CCEEEEESCSSC------------HHHHHHHHHHHHHHHHHT----------CCEEEEECSSCH----HHHHHHHHHH T ss_pred CcceEEEEeCccCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHHHHH Confidence 46889999987532 245667778887777642 233444443332 1223334433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. .+++++|+...+... .....+...++|+|..+...+ .++.+.+..+....+ T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~~~ 108 (275) T 3D8U_B 56 LE-------------------SRPAGVVLFGSEHSQ-RTHQLLEASNTPVLEIAELSS-------KASYLNIGVDHFEVG 108 (275) T ss_dssp HT-------------------TCCSCEEEESSCCCH-HHHHHHHHTTCCEEEESSSCS-------SSSCEEECCCHHHHH T ss_pred HH-------------------hCCCEEEEeCCCCCH-HHHHHHHhCCCCEEEEcCCCC-------CCCCcEEEeCHHHHH Confidence 32 478888875544333 344556678999988765432 134566677777777 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVIM 280 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv~ 280 (908) +.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....++++++ ..++|+|++ T Consensus 109 ~~~~~~l~~~g~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~i~~ 187 (275) T 3D8U_B 109 KACTRHLIEQGFKNVGFIGARGNHSTLQRQLHGWQSAMIEN-YLTPDHFLTTHEAPSSQLGAEGLAKLLLRDSSLNALVC 187 (275) T ss_dssp HHHHHHHHHTTCCCEEEEEECTTSHHHHHHHHHHHHHHHHT-TCCCCCEEEESSCCCHHHHHHHHHHHHHHCTTCCEEEE T ss_pred HHHHHHHHHCCCCcEEEEecCCCchHHHHHHHHHHHHHHHC-CCCcceEEecCCCCchhhHHHHHHHHHhcCCCCCEEEE Confidence 78888876668889999985443 4556777888877764 3433211111100111223344555542 134788876 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +..+..+++++++.|+. T Consensus 188 ~~-~~~~~~~~~~~~~~g~~ 206 (275) T 3D8U_B 188 SH-EEIAIGALFECHRRVLK 206 (275) T ss_dssp SS-HHHHHHHHHHHHHHTCC T ss_pred CC-HHHHHHHHHHHHHCCCC Confidence 64 35566778888877763 No 185 >1JHZ_B PURINE NUCLEOTIDE SYNTHESIS REPRESSOR; corepressor binding domain, purine repressor; 2.4A {Escherichia coli} SCOP: c.93.1.1 Probab=97.31 E-value=2.7e-07 Score=92.37 Aligned_cols=206 Identities=14% Similarity=0.127 Sum_probs=112.9 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|..+. .++..+..+++.++++.| +++.+.++..++ +...+.+ T Consensus 3 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 56 (289) T 1JHZ_B 3 KVNHTKSIGLLATSSEA------------AYFAEIIEAVEKNCFQKG----------YTLILGNAWNNL----EKQRAYL 56 (289) T ss_dssp -----CEEEEEESCSSC------------HHHHHHHHHHHHHHHHTT----------CEEEEEECCSCH----HHHHHHH T ss_pred ccCCcceEEEEeCCCCC------------hhHHHHHHHHHHHHHHhC----------CeEEEEecCCCH----HHHHHHH Confidence 34567899999987542 245667778887777643 233444443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++.. .++|++|+...+... .....+. ..++|+|..+...+. .++.+.+..++ T Consensus 57 ~~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~~~ 110 (289) T 1JHZ_B 57 SMMAQ-------------------KRVDGLLVMCSEYPE-PLLAMLEEYRHIPMVVMDFGEAK------ADFTDAVIDNA 110 (289) T ss_dssp HHHHH-------------------TTCSCCCEECSCCCH-HHHHHHHHTTTSCCCEEEESSCC------TTSCCEEECCH T ss_pred HHHHh-------------------cCCCEEEEecCCCCH-HHHHHHHHhCCCCEEEeeCCCcc------ccCceEEEeCh Confidence 43332 478888875443222 2233333 479999987654321 23445566666 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ...++.+++++.+.+.++++++.. +..++..+.++|++.+++. ++.+..........+..+....++++++. .+++ T Consensus 111 ~~~~~~~~~~l~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 189 (289) T 1JHZ_B 111 FEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEA-MIKVPESWIVQGDFEPESGYRAMQQILSQPHRPT 189 (289) T ss_dssp HHHHHHHHHHHHHTTCCSEEEECCC------CHHHHHHHHHHHHT-TCCCCGGGBCCCCSSHHHHHHHHHHHHSSSSCCS T ss_pred HHHHHHHHHHHHHCCCCcEEEeeCCCCccChHHHHHHHHHHHHHc-CCCCCHHHeeecCCChHHHHHHHHHHHhCCCCCc Confidence 677778888886667889999985 3345667778888888765 34433211011001112333445555421 2467 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +|++.. +..+..+++++++.|+. T Consensus 190 ~i~~~~-~~~~~~~~~~l~~~g~~ 212 (289) T 1JHZ_B 190 AVFCGG-DIMAMGALCAADEMGLR 212 (289) T ss_dssp EEEESC-HHHHHHHHHHHHHHTCC T ss_pred EEEECC-HHHHHHHHHHHHHCCCC Confidence 776654 44556778888877763 No 186 >2P9H_A Lactose operon repressor; Lac repressor, allosteric effectors, gene; HET: IPT; 2.0A {Escherichia coli} SCOP: c.93.1.1 Probab=97.30 E-value=2.8e-07 Score=91.05 Aligned_cols=199 Identities=12% Similarity=0.076 Sum_probs=116.1 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.+++++. T Consensus 1 ~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~~l~~ 55 (269) T 2P9H_A 1 LLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVHNLLA 55 (269) T ss_dssp CEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT--------CEEEEEECCS-SSH----HHHHHHHHHHHT T ss_pred CeEEEEeCcccc------------cchHHHHHHHHHHHHHcC--------CcEEEEEccC-CcH----HHHHHHHHHHHh Confidence 478999887542 255677788888887753 3344333222 111 122233443332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQA 205 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~ 205 (908) .+++++|+...+.........+...++|+|..+...+ ++++++.+++...++. T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~~~~~~ 108 (269) T 2P9H_A 56 -------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHEDGTRL 108 (269) T ss_dssp -------------------TTCSEEEEESCCCHHHHHHHHHHTTTSCEEESSSCTT--------SSSCEEEECHHHHHHH T ss_pred -------------------CCCCEEEEeCCCCChHHHHHHHHHcCCCEEEeeCCCC--------CCCCEEEECChHHHHH Confidence 4788888764443322222345678999998765432 2456667777777778 Q NP_000836.2 206 MVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMFA 282 (908) Q Consensus 206 ~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~~ 282 (908) +++++.+.+.++++++.. ++.++..+.+++++.+++. ++++....... .+..+....+++++.. .++|+|++.. T Consensus 109 ~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~i~~~~ 185 (269) T 2P9H_A 109 GVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAMLVAN 185 (269) T ss_dssp HHHHHHHHTCCCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSEEEESS T ss_pred HHHHHHHCCCCcEEEEeCCcCCHHHHHHHHHHHHHHHHC-CCCCceeecCC--CchhHHHHHHHHHHhcCCCCCEEEECC Confidence 888876667889999885 3345667778888888775 35443221111 1112233445555421 2477776664 Q NP_000836.2 283 NEDDIRRILEAAKKLNQS 300 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~ 300 (908) +..+..+++++++.|.. T Consensus 186 -~~~~~~~~~~l~~~~~~ 202 (269) T 2P9H_A 186 -DQMALGAMRAITESGLR 202 (269) T ss_dssp -HHHHHHHHHHHHHTTCC T ss_pred -HHHHHHHHHHHHHcCCC Confidence 34466777788777764 No 187 >2PAF_B Lactose operon repressor; Lac repressor, allosteric effectors, gene; HET: NPF; 3.5A {Escherichia coli} SCOP: c.93.1.1 Probab=97.30 E-value=2.8e-07 Score=91.05 Aligned_cols=199 Identities=12% Similarity=0.076 Sum_probs=116.1 Template_Neff=12.200 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) ++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.+++++. T Consensus 1 ~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~~l~~ 55 (269) T 2PAF_B 1 LLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVHNLLA 55 (269) T ss_dssp CEEEEEESCTTS------------HHHHHHHHHHHHHHGGGT--------CEEEEEECCS-SSH----HHHHHHHHHHHT T ss_pred CeEEEEeCcccc------------cchHHHHHHHHHHHHHcC--------CcEEEEEccC-CcH----HHHHHHHHHHHh Confidence 478999887542 255677788888887753 3344333222 111 122233443332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQA 205 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~ 205 (908) .+++++|+...+.........+...++|+|..+...+ ++++++.+++...++. T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~~~~~~ 108 (269) T 2PAF_B 56 -------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHEDGTRL 108 (269) T ss_dssp -------------------TTCSEEEEESCCCHHHHHHHHHHTCSSCEEESSSCTT--------SCSSEEEECHHHHHHH T ss_pred -------------------CCCCEEEEeCCCCChHHHHHHHHHcCCCEEEeeCCCC--------CCCCEEEECChHHHHH Confidence 4788888764443322222345678999998765432 2456667777777778 Q NP_000836.2 206 MVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMFA 282 (908) Q Consensus 206 ~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~~ 282 (908) +++++.+.+.++++++.. ++.++..+.+++++.+++. ++++....... .+..+....+++++.. .++|+|++.. T Consensus 109 ~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~i~~~~ 185 (269) T 2PAF_B 109 GVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAMLVAN 185 (269) T ss_dssp HHHHHHTTTCCCEEEEECCTTSHHHHHHHHHHHHHHHTT-TCCCSCEEECC--SCHHHHHHTHHHHGGGTCCCSEEEESS T ss_pred HHHHHHHCCCCcEEEEeCCcCCHHHHHHHHHHHHHHHHC-CCCCceeecCC--CchhHHHHHHHHHHhcCCCCCEEEECC Confidence 888876667889999885 3345667778888888775 35443221111 1112233445555421 2477776664 Q NP_000836.2 283 NEDDIRRILEAAKKLNQS 300 (908) Q Consensus 283 ~~~~~~~~l~~~~~~g~~ 300 (908) +..+..+++++++.|.. T Consensus 186 -~~~~~~~~~~l~~~~~~ 202 (269) T 2PAF_B 186 -DQMALGAMRAITESGLR 202 (269) T ss_dssp -HHHHHHHHHHHHHTTCC T ss_pred -HHHHHHHHHHHHHcCCC Confidence 34466777788777764 No 188 >3K4H_A putative transcriptional regulator; STRUCTURAL GENOMICS, CRYSTAL STRUCTURE,PROTEIN STRUCTURE; HET: MAL; 2.8A {Bacillus cytotoxicus NVH 391-98} Probab=97.30 E-value=2.9e-07 Score=92.38 Aligned_cols=210 Identities=10% Similarity=0.048 Sum_probs=120.5 Template_Neff=11.900 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|.++.... ...++..+..+++.++++.+ +++ .+.|...+. +...+.++ T Consensus 5 ~~~~~~Ig~v~~~~~~~~~-------~~~~~~~~~~~~~~~~~~~g--------~~~--~~~~~~~~~----~~~~~~~~ 63 (292) T 3K4H_A 5 NQTTKTLGLVMPSSASKAF-------QNPFFPEVIRGISSFAHVEG--------YAL--YMSTGETEE----EIFNGVVK 63 (292) T ss_dssp --CCCEEEEECSSCHHHHT-------TSTHHHHHHHHHHHHHHHTT--------CEE--EECCCCSHH----HHHHHHHH T ss_pred cCCCCEEEEEecCchhhhh-------cCCcHHHHHHHHHHHHHHcC--------cEE--EEECCCChH----HHHHHHHH Confidence 4568999999998641000 01355677788888877642 233 333432221 11222222 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. .+++++|+...+.. ......+...++|+|..+...+. .++++++.++... T Consensus 64 ~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~ 117 (292) T 3K4H_A 64 MVQG-------------------RQIGGIILLYSREN-DRIIQYLHEQNFPFVLIGKPYDR------KDEITYVDNDNYT 117 (292) T ss_dssp HHHT-------------------TCCCEEEESCCBTT-CHHHHHHHHTTCCEEEESCCSSC------TTTSCEEECCHHH T ss_pred HHHc-------------------CCCCEEEEecccCC-hHHHHHHHHCCCCEEEeCCCCCC------CCCccEEEcCHHH Confidence 2221 47888887654433 34445566789999987764431 2456777788877 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .++.+++++.+.+.++++++.. +...+..+.++|++.+++. ++.+........+.+..+....++++++ ..++|+| T Consensus 118 ~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~i 196 (292) T 3K4H_A 118 AAREVAEYLISLGHKQIAFIGGGSDLLVTRDRLAGMSDALKLA-DIVLPKEYILHFDFSRESGQQAVEELMGLQQPPTAI 196 (292) T ss_dssp HHHHHHHHHHHTTCCCEEEEESCTTBHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHTSSSCCSEE T ss_pred HHHHHHHHHHHCCCCeEEEEcCCcccHHHHHHHHHHHHHHHHc-CCCCChhheeccCCCHHHHHHHHHHHHhcCCCCCEE Confidence 8888888887668889999985 3345566778888887764 3444321111100111233344455442 1367787 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 197 ~~~~-~~~a~~~~~~~~~~g~~ 217 (292) T 3K4H_A 197 MATD-DLIGLGVLSALSKKGFV 217 (292) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-hHHHHHHHHHHHHcCCC Confidence 7664 44566778888877763 No 189 >4RXT_A Sugar ABC transporter; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: ARA; 1.35A {Agrobacterium radiobacter} Probab=97.30 E-value=3e-07 Score=92.78 Aligned_cols=213 Identities=11% Similarity=0.021 Sum_probs=120.7 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|.++. .++.....+++.++++. |+++.+...|+..+. +...+.+++ T Consensus 2 ~~~~~Igvi~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~~~~~~~~~~~----~~~~~~~~~ 57 (299) T 4RXT_A 2 MAEVTIPIIVKDTTS------------FYWQIVLAGARKAGKDL--------GVKVPELGAQAETDV----NGQISILEN 57 (299) T ss_dssp TTCCBCCEEESCTTS------------HHHHHHHHHHHHHHHHH--------TCBCCEEECSCTTCH----HHHHHHHHH T ss_pred CCCeEEEEEeccCCC------------hhHHHHHHHHHHHHHHh--------CCEEEEecCCcCCCH----HHHHHHHHH Confidence 357899999997542 25567778888888775 344555444432222 122333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +.. ++++++|+...+.... .....+ ..++|++..+...+. .++.+++.+++.. T Consensus 58 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~-~~~ipvv~~~~~~~~------~~~~~~v~~d~~~ 111 (299) T 4RXT_A 58 AVA-------------------GKPAAIVISPTEFKALGKPVDEA-AKSVPIIGIDSGADS------KAFKSFLTTDNTQ 111 (299) T ss_dssp HHH-------------------TCCSCEEECCSSTTTTHHHHHHH-HTTSCEEEESSCCSC------SCCSEEEECCHHH T ss_pred HHh-------------------CCCCEEEECCCChHhccHHHHHH-HhCCCEEEEccCCCc------ccccEEEecCHHH Confidence 332 4788887654443321 233334 579999987654321 2445677777777 Q NP_000836.2 202 QAQAMVDIVTA-------LGWNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 202 ~~~~~~~~l~~-------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) .++.+++++.+ .+.++++++.. +..++..+.++|++.+++.+ ++++....... .+..+....++++.+ T Consensus 112 ~~~~~~~~l~~~l~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~ 189 (299) T 4RXT_A 112 GGRIAADGLAAAIKAMTGKEEGDVVIITNTPGAGSLEQRRTGFLDQVKTKYPGLKVVADKYAD--GQATTGLNIMTDLIT 189 (299) T ss_dssp HHHHHHHHHHHHHHHHHSSSCEEEEEEESSTTCHHHHHHHHHHHHHHHHHCTTEEEEEEEECC--SCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHhhCCCCceEEEEEcCCCCchHHHHHHHHHHHHHHHCCCcEEeeeecCC--CCHHHHHHHHHHHHH Confidence 77777777654 36789999985 33456677788888776531 23332211111 111233444555542 Q NP_000836.2 272 -TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 -~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ..++++|++.. +..+..+++++++.|...++.+++. T Consensus 190 ~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~i~i~g~ 226 (299) T 4RXT_A 190 ANPKIVGVFASN-LIMAQGVGQAIAENKLSDKVKVIGF 226 (299) T ss_dssp HCTTEEEEEECS-HHHHHHHHHHHHHTTCTTTCEEEEE T ss_pred HCCCccEEEECC-hhhHHHHHHHHHHCCCCCCeEEEEE Confidence 12456665553 4456678888888776323444443 No 190 >4ZJP_A solute binding protein; Solute binding protein, ENZYME FUNCTION; HET: MSE, RIP, EDO; 1.63A {Actinobacillus succinogenes (strain ATCC 55618 / 130Z)} Probab=97.29 E-value=3e-07 Score=92.30 Aligned_cols=206 Identities=13% Similarity=0.068 Sum_probs=115.9 Template_Neff=11.800 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....++.++||++.|..+. .++.....+++.++++.| +++.+.|+..++. ... T Consensus 17 ~~~~~~~~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~----~~~ 70 (292) T 4ZJP_A 17 NLYFQSMQETIALTVSTLDN------------PFFVSLKDGAQKKATELG----------YKLVVLDSQNDPS----KEL 70 (292) T ss_dssp ------CCCEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHH T ss_pred ccccccCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHH Confidence 34566789999999997542 255677788888887753 3344455443322 222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.++++.. ++++++|. +..+.........+...++|+|..+...+. .++++++. T Consensus 71 ~~~~~l~~-------------------~~~~~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~ 125 (292) T 4ZJP_A 71 SNVEDLTV-------------------RGAKVLLINPTDSAAVSNAVAIANRNKIPVITLDRGAAK------GEVVSHIA 125 (292) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCCSEEEE T ss_pred HHHHHHHh-------------------CCCCEEEEcCCChhHHHHHHHHHHHCCCCEEEECCCCCC------CCceEEEE Confidence 33333332 35665554 333332224445566789999987654321 34677888 Q NP_000836.2 197 PPDSYQAQAMVDIVTAL---GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~---~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) +++...++.+++++.+. +.+ ++++.. ++.++..+.+++++.+++. ++.+....... .+..+....++++++ T Consensus 126 ~d~~~~~~~~~~~l~~~~~~~~~-~~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~ 201 (292) T 4ZJP_A 126 SDNVAGGKMAGDFIAQKLGDGAK-VIQLEGLAGTSAARERGEGFKQAIEAH-KFDVLASQPAD--FDRTKGLNVTENLLA 201 (292) T ss_dssp ECHHHHHHHHHHHHHHHHCTTCE-EEEEECCTTSHHHHHHHHHHHHHHHHH-TCEEEEEEECT--TCHHHHHHHHHHHHH T ss_pred cChHHHHHHHHHHHHHHhCCCcE-EEEEECCCCCHHHHHHHHHHHHHHHhc-CCeEEEeecCC--CCHHHHHHHHHHHHH Confidence 88888888888887543 344 555543 3456677788888888775 35443221111 112234445555542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) . .++++|++.. +..+..+++++++.|. T Consensus 202 ~~~~~~~i~~~~-~~~a~~~~~~~~~~g~ 229 (292) T 4ZJP_A 202 SKGSVQAIFAQN-DEMALGALRAISAAGK 229 (292) T ss_dssp HSTTCCEEEESS-HHHHHHHHHHHHHHTC T ss_pred hcCCCCEEEECC-hHHHHHHHHHHHHCCC Confidence 1 2456665543 4456678888887775 No 191 >2VK2_A ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ; TRANSPORT PROTEIN, ABC TRANSPORT, GALACTOFURANOSE; HET: GZL; 1.2A {ESCHERICHIA COLI} Probab=97.28 E-value=3.2e-07 Score=92.93 Aligned_cols=205 Identities=11% Similarity=0.090 Sum_probs=118.5 Template_Neff=11.600 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.+.. .++.....+++.++++.| +++.+.|...++ +...+.+++++ T Consensus 2 ~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~l~ 55 (306) T 2VK2_A 2 PLTVGFSQVGSES------------GWRAAETNVAKSEAEKRG----------ITLKIADGQQKQ----ENQIKAVRSFV 55 (306) T ss_dssp CCEEEEEECCCCS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHHHHHHHHH T ss_pred CcEEEEEecCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCH----HHHHHHHHHHH Confidence 5789999997632 245566677777777653 344455544332 22333444433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+.. ...++++++.+++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~d~~~~~ 113 (306) T 2VK2_A 56 A-------------------QGVDAIFIAPVVATGWEPVLKEAKDAEIPVFLLDRSIDVK---DKSLYMTTVTADNILEG 113 (306) T ss_dssp H-------------------HTCSEEEECCSSSSSCHHHHHHHHHTTCCEEEESSCCCCS---CGGGSSEEEECCHHHHH T ss_pred H-------------------cCCCEEEEcCCCccChHHHHHHHHHCCCCEEEECCCCCCC---CccceEEEEecChHHHH Confidence 2 46776665433322 2244455677899999877644321 01245677778887778 Q NP_000836.2 204 QAMVDIVTALGWN---YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET----PN 274 (908) Q Consensus 204 ~~~~~~l~~~~~~---~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~----~~ 274 (908) +.+++++.+.+.+ +++++.. ++.++..+.++|++.+++.+.+++....... .+..+....+++++.. .+ T Consensus 114 ~~~~~~l~~~~~~~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~ 191 (306) T 2VK2_A 114 KLIGDWLVKEVNGKPCNVVELQGTVGASVAIDRKKGFAEAIKNAPNIKIIRSQSGD--FTRSKGKEVMESFIKAENNGKN 191 (306) T ss_dssp HHHHHHHHHHHTTSCEEEEEEECSTTCHHHHHHHHHHHHHTTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHTTTTTT T ss_pred HHHHHHHHHHhCCCCceEEEEEcCCCCHHHHHHHHHHHHHHHhCCCeEEEeeecCC--CCHHHHHHHHHHHHHHhcCCCC Confidence 8888887554333 7888875 4456667788888887764213432211111 1112333445555421 35 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++|++.. +..+..+++++++.|+. T Consensus 192 ~d~i~~~~-~~~a~~~~~~l~~~g~~ 216 (306) T 2VK2_A 192 ICMVYAHN-DDMVIGAIQAIKEAGLK 216 (306) T ss_dssp CCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCEEEECC-HHHHHHHHHHHHHCCCC Confidence 77887664 44567788888887764 No 192 >1JFT_A PURINE NUCLEOTIDE SYNTHESIS REPRESSOR/DNA Complex; TRANSCRIPTION REGULATION, DNA-BINDING, REPRESSOR, PURINE; HET: HPA; 2.5A {Escherichia coli} SCOP: c.93.1.1, a.35.1.5 Probab=97.28 E-value=3.2e-07 Score=94.53 Aligned_cols=206 Identities=14% Similarity=0.133 Sum_probs=119.1 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++.....+++.++++.| +++.+.++..+. +...+.+ T Consensus 54 ~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~~ 107 (340) T 1JFT_A 54 KVNHTKSIGLLATSSEA------------AYFAEIIEAVEKNCFQKG----------YTLILGNAWNNL----EKQRAYL 107 (340) T ss_dssp HHTCCCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred ccCCCCEEEEEeCCCCc------------chHHHHHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHHH Confidence 34578899999987542 255677788888877653 233444443332 2223333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++.. .++|++|+....... .....+. ..++|+|..+...+. .++.+.+..++ T Consensus 108 ~~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~~ 161 (340) T 1JFT_A 108 SMMAQ-------------------KRVDGLLVMCSEYPE-PLLAMLEEYRHIPMVVMDAGEAK------ADFTDAVIDNA 161 (340) T ss_dssp HHHHH-------------------TTCSEEEECCSCCCH-HHHHHHHTTTTSCEEESSCSSCC------CSSSEEEECCH T ss_pred HHHHh-------------------cCCCEEEEeCCCCCH-HHHHHHHHhcCCCEEEEcCCccC------CCCCcEEEeCH Confidence 43332 478888875443222 2233333 479999987764431 23445666666 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNAR 276 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~ 276 (908) ...++.+++++.+.++++++++.. +..++..+.++|++.+++. ++.+........+.+..+....++++++ ..++| T Consensus 162 ~~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d 240 (340) T 1JFT_A 162 FEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEA-MIKVPESWIVQGDFEPESGYRAMQQILSQPHRPT 240 (340) T ss_dssp HHHHHHHHHHHHHHTCCCEEEECCCTTSCCCCCHHHHHHHHHHHH-TCCCCGGGBCCCCSSHHHHHHHHHHHHTSSSCCS T ss_pred HHHHHHHHHHHHHCCCCeEEEEeCCccccchHHHHHHHHHHHHHC-CCCCCHHHeeecCCChHHHHHHHHHHHcCCCCCC Confidence 667778888876668889999985 3345667788888888765 3444321111100111233344555542 12477 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +|++.. +..+..+++++++.|+. T Consensus 241 ~i~~~~-~~~~~~~~~~l~~~g~~ 263 (340) T 1JFT_A 241 AVFCGG-DIMAMGALCAADEMGLR 263 (340) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCC T ss_pred EEEECC-HHHHHHHHHHHHHcCCC Confidence 777664 34456777788777763 No 193 >3BRS_B Periplasmic binding protein/LacI transcriptional regulator; STRUCTURAL GENOMICS, PROTEIN STRUCTURE INITIATIVE; 2.0A {Clostridium phytofermentans} Probab=97.28 E-value=3.3e-07 Score=91.85 Aligned_cols=215 Identities=11% Similarity=-0.043 Sum_probs=121.6 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.+.++.. ..++.....+++.++++.+ +++.+...|...+. +...+.+++ T Consensus 3 ~~~~~i~~~~~~~g~~----------~~~~~~~~~g~~~a~~~~g--------~~~~~~~~~~~~~~----~~~~~~~~~ 60 (289) T 3BRS_B 3 LKQYYMICIPKVLDDS----------SDFWSVLVEGAQMAAKEYE--------IKLEFMAPEKEEDY----LVQNELIEE 60 (289) T ss_dssp --CCEEEEECSCCCSS----------CHHHHHHHHHHHHHHHHHT--------CEEEECCCSSTTCH----HHHHHHHHH T ss_pred CcceEEEEeecCCCCC----------ChHHHHHHHHHHHHHHHhC--------CEEEEECCCCCCCH----HHHHHHHHH Confidence 4578899988875432 1355677888888888763 44555544432222 122333444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. .+++++|+...+.. .......+...++|+|......+. .++.+++.++... T Consensus 61 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~ 115 (289) T 3BRS_B 61 AIK-------------------RKPDVILLAAADYEKTYDAAKEIKDAGIKLIVIDSGMKQ------DIADITVATDNIQ 115 (289) T ss_dssp HHH-------------------TCCSEEEECCSCTTTTHHHHTTSGGGTCEEEEESCCCSS------CCCSEEEECCHHH T ss_pred HHH-------------------hCCCEEEEcCCChHhhHHHHHHHHHCCCEEEEECCCCCc------ccccEEEEcCHHH Confidence 332 47887776544332 224445566789999987654321 2456677777777 Q NP_000836.2 202 QAQAMVDIVTALG--WNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNAR 276 (908) Q Consensus 202 ~~~~~~~~l~~~~--~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~ 276 (908) .++.+++++.+.+ .++++++... ..++..+.+++++.+++. ++.+....... .+..+....++++++ ..+++ T Consensus 116 ~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 192 (289) T 3BRS_B 116 AGIRIGAVTKNLVRKSGKIGVISFVKNSKTAMDREEGLKIGLSDD-SNKIEAIYYCD--SNYDKAYDGTVELLTKYPDIS 192 (289) T ss_dssp HHHHHHHHHHHHTSSSCEEEEEESCTTSHHHHHHHHHHHHHHGGG-GGGEEEEEECT--TCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHhcCCceEEEEEccCCChHHHHHHHHHHHHHhcC-CCcEEEEEecC--CCHHHHHHHHHHHHHHCCCce Confidence 7777877775544 6789988733 335666778888887764 34443211111 111223334455542 12467 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.|...++.+++. T Consensus 193 ~i~~~~-~~~a~~~~~~~~~~g~~~~~~i~~~ 223 (289) T 3BRS_B 193 VMVGLN-QYSATGAARAIKDMSLEAKVKLVCI 223 (289) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCTTTCEEEEE T ss_pred EEEECC-hhhHHHHHHHHHHCCCcCCeEEEEE Confidence 776553 4445667777777776323444443 No 194 >4RK4_A Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: GLC; 1.32A {Lactobacillus casei ATCC 334} Probab=97.27 E-value=3.4e-07 Score=91.30 Aligned_cols=205 Identities=15% Similarity=0.126 Sum_probs=115.7 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||+++|..+. .++..+..+++.++++.+ +++.+.+...+. +...+.+ T Consensus 5 ~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 58 (283) T 4RK4_A 5 RAQATGNIGVLVSRVTN------------PFFAGLFDAIERELHAHG----------YQVMITQTYDDP----EAEERFL 58 (283) T ss_dssp ----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred ccCCCCeEEEEEccCCC------------hhHHHHHHHHHHHHHHCC----------CEEEEEcCCCCH----HHHHHHH Confidence 34568999999997542 255667778877776542 334444443332 2233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++.. .++|++|+...+... .....++..++|++..+...+. +..+.+..++. T Consensus 59 ~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~pvv~~~~~~~~-------~~~~~v~~d~~ 111 (283) T 4RK4_A 59 KQLKS-------------------RELDGVILASVEAPD-RVMAVAKAFPGRVVVVNADVQI-------PGATSLVLPHY 111 (283) T ss_dssp HHHHT-------------------TSSSEEEESCCSCHH-HHHHHHHHSTTSEEEESSSCCC-------TTSEEECCCHH T ss_pred HHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEEcCCCCC-------CCCcEEEeChH Confidence 44332 478888875544333 3334556678998887654321 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN----YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE---TP 273 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~---~~ 273 (908) ..++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....+++++. .. T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (283) T 4RK4_A 112 QATRDALDYLFNQGHRRFAYVSGGTISGAHHGQSRTQAFLDFMQAH-QLLVAQDLLFGQIHTAKEGQAVGKQLASLAPNV 190 (283) T ss_dssp HHHHHHHHHHHHTTCCSEEEECSSCTTSSCTTHHHHHHHHHHHHHT-TCCCCGGGEECSCCSHHHHHHHHHHHHTSCTTT T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCCCCcchHHHHHHHHHHHHHC-CCccchhHccCCCCChhHHHHHHHHHHHhCccC Confidence 67777888877668889999885432 4556777888877764 3433221111100011122333344431 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++|+|++.. +..+..+++++++.|+. T Consensus 191 ~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (283) T 4RK4_A 191 RPDAVFTNS-DEVAVGVIDSLLAADVK 216 (283) T ss_dssp SCSEEECSC-HHHHHHHHHHHHHTTCC T ss_pred CCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 678887664 44566788888887764 No 195 >4RK5_A Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: SUC; 1.35A {Lactobacillus casei ATCC 334} Probab=97.27 E-value=3.4e-07 Score=91.30 Aligned_cols=205 Identities=15% Similarity=0.126 Sum_probs=115.7 Template_Neff=12.200 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||+++|..+. .++..+..+++.++++.+ +++.+.+...+. +...+.+ T Consensus 5 ~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 58 (283) T 4RK5_A 5 RAQATGNIGVLVSRVTN------------PFFAGLFDAIERELHAHG----------YQVMITQTYDDP----EAEERFL 58 (283) T ss_dssp ----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred ccCCCCeEEEEEccCCC------------hhHHHHHHHHHHHHHHCC----------CEEEEEcCCCCH----HHHHHHH Confidence 34568999999997542 255667778877776542 334444443332 2233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++.. .++|++|+...+... .....++..++|++..+...+. +..+.+..++. T Consensus 59 ~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~~pvv~~~~~~~~-------~~~~~v~~d~~ 111 (283) T 4RK5_A 59 KQLKS-------------------RELDGVILASVEAPD-RVMAVAKAFPGRVVVVNADVQI-------PGATSLVLPHY 111 (283) T ss_dssp HHHHT-------------------TSCSEEEESSCSCHH-HHHHHHHHSTTSEEEESSSCCC-------TTSEEECCCHH T ss_pred HHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEEcCCCCC-------CCCcEEEeChH Confidence 44332 478888875544333 3334556678998887654321 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN----YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE---TP 273 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~---~~ 273 (908) ..++.+++++.+.+.++++++..+.. .+..+.++|++.+++. ++.+..........+..+....+++++. .. T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 190 (283) T 4RK5_A 112 QATRDALDYLFNQGHRRFAYVSGGTISGAHHGQSRTQAFLDFMQAH-QLLVAQDLLFGQIHTAKEGQAVGKQLASLAPNV 190 (283) T ss_dssp HHHHHHHHHHHHTTCCSEEEECSSCTTSSCTTHHHHHHHHHHHHHT-TCCCCGGGEECSCCSHHHHHHHHHHHHTSCTTT T ss_pred HHHHHHHHHHHHCCCCeEEEEeCCCCCCCcchHHHHHHHHHHHHHC-CCccchhHccCCCCChhHHHHHHHHHHHhCccC Confidence 67777888877668889999885432 4556777888877764 3433221111100011122333344431 13 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++|+|++.. +..+..+++++++.|+. T Consensus 191 ~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (283) T 4RK5_A 191 RPDAVFTNS-DEVAVGVIDSLLAADVK 216 (283) T ss_dssp SCSEEECSC-HHHHHHHHHHHHHTTCC T ss_pred CCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 678887664 44566788888887764 No 196 >2QU7_B Putative transcriptional regulator; STRUCTURAL GENOMICS, TRANSCRIPTION, PSI-2, Protein; 2.3A {Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305} Probab=97.26 E-value=3.6e-07 Score=91.52 Aligned_cols=200 Identities=12% Similarity=0.073 Sum_probs=119.6 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|... .++.....+++.++++.| +++.+.++..++. ...+.++ T Consensus 5 ~~~~~~I~~~~~~~~-------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~~ 57 (288) T 2QU7_B 5 TGRSNIIAFIVPDQN-------------PFFTEVLTEISHECQKHH----------LHVAVASSEENED----KQQDLIE 57 (288) T ss_dssp --CEEEEEEEESSCC-------------HHHHHHHHHHHHHHGGGT----------CEEEEEECTTCHH----HHHHHHH T ss_pred CCCCCEEEEEecCCC-------------hHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHH Confidence 456889999999742 245677788888877653 2334444433321 2223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ++++++|+...+.... ..+...++|+|..+...+ .++.+++..++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~---~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~ 108 (288) T 2QU7_B 58 TFVS-------------------QNVSAIILVPVKSKFQ---MKREWLKIPIMTLDRELE-------STSLPSITVDNEE 108 (288) T ss_dssp HHHH-------------------TTEEEEEECCSSSSCC---CCGGGTTSCEEEESSCCT-------TCCCCEEEECHHH T ss_pred HHHH-------------------CCCCEEEEecCCcchh---hhHHhcCCCEEEeCCCCC-------CCCCCEEEeChHH Confidence 3332 4788888765443322 234677999988765432 1345677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPRE------PRPGEFEKIIKRLLETP 273 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~------~~~~~~~~~~~~l~~~~ 273 (908) .++.+++++.+.+.++++++..+. .++..+.+++++.+++. ++.+.....+... .+..+....+++++. . T Consensus 109 ~~~~~~~~l~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~ 186 (288) T 2QU7_B 109 AAYIATKRVLESTCKEVGLLLANPNISTTIGRKNGYNKAISEF-DLNVNPSLIHYSDQQLGTNAQIYSGYEATKTLLS-K 186 (288) T ss_dssp HHHHHHHHHHTTTCCSEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSCSHHHHHHHHHHHHHHHHH-T T ss_pred HHHHHHHHHHHcCCCcEEEEecCCCCcchHHHHHHHHHHHHHC-CCCCCcccEEeecCCCCCchhHHHHHHHHHHHHh-c Confidence 788888888777888999998543 35667788888888765 3433211111000 011223344555553 4 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++|+|++.. +..+..+++++++.|+. T Consensus 187 ~~d~i~~~~-~~~a~~~~~~l~~~g~~ 212 (288) T 2QU7_B 187 GIKGIVATN-HLLLLGALQAIKESEKE 212 (288) T ss_dssp TCCEEEECS-HHHHHHHHHHHHHSSCC T ss_pred CCCEEEEcC-cHHHHHHHHHHHHcCCC Confidence 788887764 44567788888877763 No 197 >4IRX_B Sugar ABC transporter, periplasmic sugar-binding; ABC transporter, periplasmic binding protein; HET: INS, MSE; 1.451A {Caulobacter crescentus} Probab=97.26 E-value=3.7e-07 Score=91.76 Aligned_cols=208 Identities=13% Similarity=0.057 Sum_probs=119.3 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|..+. .++.....+++.++++.+ +++.+.|+..++. ...+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~~~ 57 (296) T 4IRX_B 4 PRGSHMEVVVSFNDLSQ------------PFFVAMRRELEDEAAKLG----------VKVQVLDAQNNSS----KQISDL 57 (296) T ss_dssp CCCSSCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHH T ss_pred CCCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHH Confidence 45578999999986532 255677788888887753 3344555543322 223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++. +++++++. +..+.........+...++|+|..+...+. ..++++++.+++ T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~ 113 (296) T 4IRX_B 58 QAAAV-------------------QGAKVVIVAPTDSKALAGAADDLVEQGVAVISVDRNIAG-----GKTAVPHVGADN 113 (296) T ss_dssp HHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCS-----SSSCCCEEEECH T ss_pred HHHHH-------------------CCCCEEEEecCChhhHHHHHHHHHHCCCEEEEEcCCCCC-----CCceeeEEecCh Confidence 43332 46776654 333332224445566789999987764331 134567777887 Q NP_000836.2 200 SYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE---T 272 (908) Q Consensus 200 ~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~---~ 272 (908) ...++.+++++.+. +.++++++.. ++.++..+.+++++.+++. +..+..........+..+....+++++. . T Consensus 114 ~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~ 192 (296) T 4IRX_B 114 VAGGRAMADWVVKTYPAGARVVVITNDPGSSSSIERVKGVHDGLAAG-GPAFKIVTEQTANSKRDQALTVTQNILTSMRD 192 (296) T ss_dssp HHHHHHHHHHHHHHCTTCEEEEEEESCTTSHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHHHHTTT T ss_pred HHHHHHHHHHHHHHCCCCCEEEEEEcCCCCchHHHHHHHHHHHHHcc-CCCcEEEeeecCCCCHHHHHHHHHHHHHhCCC Confidence 77788888887654 5678998875 3345666777888877764 2332211111000111122233333331 1 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .++++|++.. +..+..+++++++.|+. T Consensus 193 ~~~~~i~~~~-~~~a~~~~~~l~~~g~~ 219 (296) T 4IRX_B 193 TPPDVILCLN-DDMAMGALEAVRAAGLD 219 (296) T ss_dssp SCCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCCCEEEEcC-ChhHHHHHHHHHHCCCC Confidence 3577776664 34466778888877763 No 198 >4RY9_A Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: GOL, TLZ; 1.4A {Verminephrobacter eiseniae EF01-2} Probab=97.25 E-value=3.9e-07 Score=91.91 Aligned_cols=205 Identities=13% Similarity=0.041 Sum_probs=116.9 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++..+..+++.++++.+ +++.+.++..++. ...+.++ T Consensus 4 ~~~~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (302) T 4RY9_A 4 QTGAFKIGVSMKTLSA------------PYFAAQMEAAKARGKELG----------YEVLATDAQGKLQ----KQISDVE 57 (302) T ss_dssp --CCCEEEEEESCCCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHH T ss_pred cCCCeEEEEEECCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHHH Confidence 3567899999987542 245567777777776632 3444555443321 2223334 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .+++++|+...+.... .....+...++|+|..+...+. ..++++++.+++. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~~~~ 113 (302) T 4RY9_A 58 DLVT-------------------RGVKLLIINPADSEGLVNAVNNASANGVKVVVIDSTLNP-----RANFVTQVQSSNS 113 (302) T ss_dssp HHHH-------------------TTEEEEEEECSCTTTTHHHHHHHHHTTCEEEEESSCCCT-----TSCCSEEEECCHH T ss_pred HHHH-------------------CCCCEEEEecCCcccHHHHHHHHHHCCCEEEEECCCCCC-----cccceEEEecChh Confidence 3332 4788777654443322 3445566789999987754331 1345667777777 Q NP_000836.2 201 YQAQAMVDIVTA-L--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVC--------IAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 201 ~~~~~~~~~l~~-~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~--------v~~~~~~~~~~~~~~~~~~~~ 267 (908) ..+..+++++.+ . +.++++++.. ++.++..+.+++++.+++. ++. +....... .+..+....++ T Consensus 114 ~~~~~~~~~l~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~ 190 (302) T 4RY9_A 114 INGALVGHWVIEEVGNKSLKIALLSGEKGNPVGQERRLGVLSGIIEA-QLRKFGKADLTVVGQGWGH--WNDEGGLKAME 190 (302) T ss_dssp HHHHHHHHHHHHHHTTCCCEEEEEECCTTCHHHHHHHHHHHHHHHHH-HHHHHSCCCCEEEEEEECT--TSHHHHHHHHH T ss_pred HhHHHHHHHHHHHhCCCccEEEEEEcCCCChHHHHHHHHHHHHHHHH-HHHHhCCCCEEEEeeeecC--CCHHHHHHHHH Confidence 777788887754 2 3578999985 3445666777788777664 232 21111111 11123444455 Q NP_000836.2 268 RLLET-PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 268 ~l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++.. .++++|++.. +..+..+++++++.|+. T Consensus 191 ~~~~~~~~~~~i~~~~-~~~a~~~~~~~~~~g~~ 223 (302) T 4RY9_A 191 DLLVANKDINMVLGEN-DSMVLGARRAIESAGRT 223 (302) T ss_dssp HHHHHCSCCCEEEESS-HHHHHHHHHHHHHHTCC T ss_pred HHHHhCCCCCEEEeCC-hHHHHHHHHHHHHcCCC Confidence 55421 2466666553 44566778888877764 No 199 >3G1W_A Sugar ABC transporter; Sugar ABC transporter, Sugar-binding protein; 2.02A {Bacillus halodurans C-125} Probab=97.24 E-value=4e-07 Score=92.08 Aligned_cols=213 Identities=14% Similarity=0.059 Sum_probs=117.4 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~~ 121 (908) .++++||++.|.... .++.....+++.++++.+ + ++.+.+ +..++ +...+.++ T Consensus 2 ~~~~~Igvl~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~~~~ 55 (305) T 3G1W_A 2 SLNETYMMITFQSGM------------DYWKRCLKGFEDAAQALN--------V--TVEYRGAAQYDI----QEQITVLE 55 (305) T ss_dssp ---CEEEEEESSTTS------------THHHHHHHHHHHHHHHHT--------C--EEEEEECSSSCH----HHHHHHHH T ss_pred CCCeEEEEEecCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEecccCCCH----HHHHHHHH Confidence 357899999997632 245567778887777642 3 333444 32222 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.++.. T Consensus 56 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 110 (305) T 3G1W_A 56 QAIA-------------------KNPAGIAISAIDPVELTDTINKAVDAGIPIVLFDSGAPD------SHAHSFLGTNNY 110 (305) T ss_dssp HHHH-------------------HCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHH T ss_pred HHHH-------------------cCCCEEEEeCCCHHHHHHHHHHHHHCCCCEEEEcCCCCC------ccccEEEeCCHH Confidence 3332 467877764433322 23445566779999987654321 245667777777 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..+..+++++.+. +.++++++.... .....+.+++++.+++. +..+..........+..+....++++++. .++| T Consensus 111 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d 189 (305) T 3G1W_A 111 NAGMNAAYKMAELLDGEGEVAVITLPNQLNHQERTTGFKETLEAE-FPAIEVIAVEDGRGDSLHSRRVAHQLLEDYPNLA 189 (305) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEEECTTCHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHHcCCCcEEEEEECCCcccHHHHHHHHHHHHHHH-CCCeEEEEEecCCCChHHHHHHHHHHHHHCCCcc Confidence 7777888887655 778999998532 45566777888877654 23222111111001112334445555421 2477 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.+...++.+++. T Consensus 190 ~i~~~~-~~~a~~~~~~l~~~~~~~~v~ii~~ 220 (305) T 3G1W_A 190 GIFATE-ANGGVGVGDAVRLESRAGEIQIISF 220 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCTTTSEEEEE T ss_pred EEEEec-CCcchHHHHHHHHccCCCCEEEEEE Confidence 787664 3455667777777664323444443 No 200 >3G1W_B Sugar ABC transporter; Sugar ABC transporter, Sugar-binding protein; HET: MSE; 2.02A {Bacillus halodurans C-125} Probab=97.24 E-value=4e-07 Score=92.08 Aligned_cols=213 Identities=14% Similarity=0.059 Sum_probs=118.2 Template_Neff=11.700 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTFVQ 121 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~~~ 121 (908) .++++||++.|.... .++.....+++.++++.+ + ++.+.+ +..++ +...+.++ T Consensus 2 ~~~~~Igvl~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~~~~ 55 (305) T 3G1W_B 2 SLNETYMMITFQSGM------------DYWKRCLKGFEDAAQALN--------V--TVEYRGAAQYDI----QEQITVLE 55 (305) T ss_dssp --CCEEEEEEESTTS------------THHHHHHHHHHHHHHHHT--------C--EEEEEEESSSCH----HHHHHHHH T ss_pred CCCeEEEEEecCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEecccCCCH----HHHHHHHH Confidence 357899999997632 245567778887777642 3 333444 32222 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+... ......+...++|+|..+...+. .++++++.++.. T Consensus 56 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 110 (305) T 3G1W_B 56 QAIA-------------------KNPAGIAISAIDPVELTDTINKAVDAGIPIVLFDSGAPD------SHAHSFLGTNNY 110 (305) T ss_dssp HHHH-------------------HCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHH T ss_pred HHHH-------------------cCCCEEEEeCCCHHHHHHHHHHHHHCCCCEEEEcCCCCC------ccccEEEeCCHH Confidence 3332 467877764433322 23445566779999987654321 245667777777 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..+..+++++.+. +.++++++.... .....+.+++++.+++. +..+..........+..+....++++++. .++| T Consensus 111 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d 189 (305) T 3G1W_B 111 NAGMNAAYKMAELLDGEGEVAVITLPNQLNHQERTTGFKETLEAE-FPAIEVIAVEDGRGDSLHSRRVAHQLLEDYPNLA 189 (305) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEEECTTCHHHHHHHHHHHHHHHHH-CTTEEEEEEEECTTCHHHHHHHHHHHHHHCTTEE T ss_pred HHHHHHHHHHHHHcCCCcEEEEEECCCcccHHHHHHHHHHHHHHH-CCCeEEEEEecCCCChHHHHHHHHHHHHHCCCcc Confidence 7777888887655 778999998532 45566777888877654 23222111111001112334445555421 2477 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++.. +..+..+++++++.+...++.+++. T Consensus 190 ~i~~~~-~~~a~~~~~~l~~~~~~~~v~ii~~ 220 (305) T 3G1W_B 190 GIFATE-ANGGVGVGDAVRLESRAGEIQIISF 220 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTCTTTSEEEEE T ss_pred EEEEec-CCcchHHHHHHHHccCCCCEEEEEE Confidence 787664 3455667777777664323444443 No 201 >5XSD_B Periplasmic binding protein/LacI transcriptional regulator; Two component system, histidine kinase; 2.5A {Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)} Probab=97.23 E-value=4.3e-07 Score=91.87 Aligned_cols=217 Identities=17% Similarity=0.071 Sum_probs=121.3 Template_Neff=11.900 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ......++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+. T Consensus 13 ~~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~ 67 (306) T 5XSD_B 13 EKEPIKPKIVLISHIKTN------------PYWLDIKAGAERAAKERG--------AVVEFLGPTT-AST----EDGLKL 67 (306) T ss_dssp ---CCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHHT--------CEEEEECCSS-CCH----HHHHHH T ss_pred cCCCCCCeEEEEecCCCC------------HHHHHHHHHHHHHHHHcC--------CEEEEeCCCC-CCH----HHHHHH Confidence 345578999999986542 255677888888887753 3444433222 221 122233 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) ++++.. .++|++| ++..+.........+...++|+|..+...+. .++++++.++ T Consensus 68 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 122 (306) T 5XSD_B 68 FDMATS-------------------AKVSGIITYVQEEGQYKKKINSAMEKGIPVVTIASDEED------SNRIAYVGTD 122 (306) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCS------SCCSEEEEEC T ss_pred HHHHHh-------------------CCCCEEEEeCCChhHHHHHHHHHHHCCCCEEEEcCCCCC------cCCeEEEecC Confidence 333332 4778777 4433332223445566789999987654321 2456677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL-GW-NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-P 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~~-~~-~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~ 273 (908) ....+..+++++.+. +. ++++++.. ++.++..+.++|++.+++.+.+.+....... .+..+....+++++.. . T Consensus 123 ~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 200 (306) T 5XSD_B 123 NVLAGQVAGKEMVKQIGTSGNVAIVMGGKNVKNQKERVEGFTQYIKSNSNLKIVDTDSSD--AMLLEAEIITRKILNRND 200 (306) T ss_dssp HHHHHHHHHHHHHHHHCSSSEEEEECSCTTCHHHHHHHHHHHHHHHHHCCCEEECCCCTT--TTTCCHHHHHHHHHHHCT T ss_pred HHHHHHHHHHHHHHHHCCCceEEEEECCCCcccHHHHHHHHHHHHHhcCCcEEeeeecCc--hhHHHHHHHHHHHHHhCC Confidence 777777888887654 65 88998875 3345667778888877764213332211111 1112233445555421 2 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ++++|++.. +..+..+++++++.|+..++.+++.+ T Consensus 201 ~~~~i~~~~-~~~a~~~~~~~~~~g~~~~~~vi~~~ 235 (306) T 5XSD_B 201 NINALFCTS-ALDGIGAARAVKDLNYKDRVKIICFD 235 (306) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHTTCBTTBEEEEES T ss_pred CCCEEEECC-cchHHHHHHHHHHcCCCCCeEEEEeC Confidence 467776654 44566777777777763234444443 No 202 >5DKV_A ABC transporter substrate binding protein; Solute Binding Protein, ENZYME FUNCTION; HET: T6T; 1.68A {Agrobacterium vitis (strain S4 / ATCC BAA-846)} Probab=97.23 E-value=4.3e-07 Score=92.85 Aligned_cols=219 Identities=10% Similarity=0.013 Sum_probs=124.2 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDT-CSRDTYALEQSLTFV 120 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~-~~~~~~a~~~~~~~~ 120 (908) .++.++||++.|..+. ..+.....+++.++++.| + ++.+.+. ..++ +...+.+ T Consensus 24 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~l~~~~~~~~~~----~~~~~~~ 77 (324) T 5DKV_A 24 ENKKFRIALIPGLTTD------------AFYITMHKGAEAAAAAIG--------A--QIIFQGAPDFNP----VTQVPVL 77 (324) T ss_dssp SSCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHHT--------C--EEEECCCSSSCH----HHHHHHH T ss_pred cCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------C--EEEEeCCCCCCH----HHHHHHH Confidence 3468999999887542 245677788888887753 2 3333433 2222 2233344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELS----DNTRYDFFSRV 195 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~----~~~~~~~~~~~ 195 (908) ++++. ++++++|+...+... ......+...++|+|..+...+... .....++++++ T Consensus 78 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~v 138 (324) T 5DKV_A 78 DAVIA-------------------KKPDAILIAPTDTTQLVQPLKKAADAGIPMITVDTFIGTGDYQTGAGDGDFPLSYI 138 (324) T ss_dssp HHHHT-------------------TCCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCSTTSCCSSSCSTTCCSSCEE T ss_pred HHHHH-------------------hCCCEEEECCCCchHhHHHHHHHHHCCCCEEEEcCCCCCCcccCCCCCCCCCcEEE Confidence 44332 467877764433322 2444556678999998775433100 00013456777 Q NP_000836.2 196 VPPDSYQAQAMVDIVT-ALGWNYVSTLAS---EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~-~~~~~~v~ii~~---~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) .++....++.+++++. +.+.++++++.. ++.++..+.++|++.+++..++.+....... .+..+....+++++. T Consensus 139 ~~d~~~~~~~~~~~l~~~~~~~~~~~i~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 216 (324) T 5DKV_A 139 ASDNVLGGEIAARSLALAIGDKGKVYVSNVKPGVSTTDQREQGFKSEMAKHPGITVLETQFND--NDANKAASQLQAVYA 216 (324) T ss_dssp EECHHHHHHHHHHHHHHHTTTCEEEEEEESCTTCHHHHHHHHHHHHHHTTCTTEEECCCEECT--TCHHHHHHHHHHHHH T ss_pred ecCHHHHHHHHHHHHHHHHCCCceEEEEEcCCCCChHHHHHHHHHHHHhhCCCcEEEEeeeCC--CCHHHHHHHHHHHHH Confidence 7887777888888874 667788888875 3345667778888877654124433221111 112234445555543 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) . .++++|++.. +..+..+++++++.|...++.+++. T Consensus 217 ~~~~~~~i~~~~-~~~a~~~~~al~~~g~~~~i~i~~~ 253 (324) T 5DKV_A 217 RNPDLAGVFGAN-LFSGLGSANGVQQAGQSGTIKVVAF 253 (324) T ss_dssp HCTTCCEEEECS-HHHHHHHHHHHHHTTCBTTBEEEEE T ss_pred HCCCccEEEEcC-cchhHHHHHHHHHcCCCCceEEEEe Confidence 1 2467776654 4456678888887776323444443 No 203 >1ZVV_B Glucose-resistance amylase regulator/HPr-like protein crh/DNA; ccpa crh dna; HET: SEP, IOD; 2.98A {Bacillus subtilis} SCOP: c.93.1.1, a.35.1.5 Probab=97.23 E-value=4.3e-07 Score=93.15 Aligned_cols=204 Identities=11% Similarity=0.116 Sum_probs=120.1 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 57 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 110 (332) T 1ZVV_B 57 SKKTTTVGVIIPDISN------------IFYAELARGIEDIASMYK--------Y--NIILSNSDQNQ----DKQLHLLN 110 (332) T ss_dssp HTCCSEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------C--eEEEEeCCCCH----HHHHHHHH Confidence 4568899999987542 245667778887777642 2 33444443332 12223344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+. .......+...++|+|..+...+ .+..+.+.++... T Consensus 111 ~l~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 163 (332) T 1ZVV_B 111 NMLG-------------------KQVDGIIFMSGNV-TEEHVEELKKSPVPVVLAASIES-------TNQIPSVTIDYEQ 163 (332) T ss_dssp HHHH-------------------HTCSEEEECCSCC-CHHHHHHHTTCSSCEEEESCCCT-------TCCSCEECCCHHH T ss_pred HHHh-------------------CCCCEEEEeCCCC-CHHHHHHHHhCCCCEEEECCCCC-------CCCCCEEEeCHHH Confidence 4332 4788888754443 23445556678999998765322 1345566667767 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .+..+++++.+.+.+++++++.+.. .+..+.+++++.+++. ++.+.....+..+.+..+....+++++. ..++|+ T Consensus 164 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 242 (332) T 1ZVV_B 164 AAFDAVQSLIDSGHKNIAFVSGTLEEPINHAKKVKGYKRALTES-GLPVRDSYIVEGDYTYDSGIEAVEKLLEEDEKPTA 242 (332) T ss_dssp HHHHHHHHHHHTTCCCEEEECSCTTSHHHHTTHHHHHHHHHHHH-TCCCCTTSCCCCCSSHHHHHHHHHHHHSSSSCCSE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCCCCcccHHHHHHHHHHHHHHc-CCCCCHHHeecCCCCHHHHHHHHHHHHhcCCCCCE Confidence 7777888876668889999985433 4567778888887764 3443221111111112234445555542 136788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 243 i~~~~-~~~a~~~~~~l~~~g~~ 264 (332) T 1ZVV_B 243 IFVGT-DEMALGVIHGAQDRGLN 264 (332) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 87664 44556777888877763 No 204 >4KQ9_A Ribose ABC transporter, substrate binding; ABC transporter, ribose binding, PSI-Biology; HET: GOL; 1.9A {Conexibacter woesei} Probab=97.22 E-value=4.6e-07 Score=91.20 Aligned_cols=205 Identities=13% Similarity=-0.005 Sum_probs=119.4 Template_Neff=12.100 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|.... .++.....+++.++++.+ +++.+.|+..++. ...+.++ T Consensus 4 ~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~ 57 (299) T 4KQ9_A 4 SAAGKKVVYSTFGAQI------------PFFNRIGEGAKAQATVRR----------LDFDISTSEIDPG----KQIDSID 57 (299) T ss_dssp CCTTCEEEEEEECTTC------------HHHHHHHHHHHHHHHHTT----------CEEEEEEECSSHH----HHHHHHH T ss_pred ccCceEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC----------CeEEEecCCCCHH----HHHHHHH Confidence 4568899999983221 355677788888777632 3444455444322 2233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI-MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~-~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. .+++++|+...+.... .....+...++|+|..+...+. ..++++++.+++. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~-----~~~~~~~v~~d~~ 113 (299) T 4KQ9_A 58 NAVA-------------------QQPDGLIVSPIDGSALVPTIKGAVEDGVPVILLADGLSE-----DVGQLSFVGSDFA 113 (299) T ss_dssp HHHH-------------------TCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS-----CCCCSEEEECCHH T ss_pred HHHH-------------------cCCCEEEECCCCccccHHHHHHHHHCCCcEEEECCCCCC-----cccceEEEEcCHH Confidence 3332 4778777644333221 3445566789999987654321 1345677778887 Q NP_000836.2 201 YQAQAMVDIVTAL-G-WNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 201 ~~~~~~~~~l~~~-~-~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ..++.+++++.+. + .++++++..+. .++..+.++|++.+++. ++.+........ .+..+....+.++++ ..++ T Consensus 114 ~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~ 191 (299) T 4KQ9_A 114 EIGRLKATYIADRLGDGGTVAMVNGTRGMSFVEEQGEAAREVFEER-GIEIVDDVYTKA-ITPDEGLTATQNILTRHSDV 191 (299) T ss_dssp HHHHHHHHHHHHHCCTTCEEEEECCSTTCHHHHHHHHHHHHHHHHH-TCEEEEEECCSS-SCHHHHHHHHHHHHHHCTTC T ss_pred HHHHHHHHHHHHHhCCCcEEEEEeCCCCChHHHHHHHHHHHHHHhc-CcEEecccccCC-CCHHHHHHHHHHHHHhCCCC Confidence 7788888887654 6 68999998533 35666778888887765 344432111110 111233344555542 1356 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++|++.. +..+..+++++++.|+ T Consensus 192 ~~i~~~~-~~~~~~~~~~l~~~g~ 214 (299) T 4KQ9_A 192 GAIYYSG-DDGALGGIRAIAARNI 214 (299) T ss_dssp CEEEESS-HHHHHHHHHHHHHTTC T ss_pred CEEEEcC-cchHHHHHHHHHHCCC Confidence 7776654 3455667788877776 No 205 >5XSS_A Periplasmic binding protein/LacI transcriptional regulator; Two component system, histidine kinase; HET: XYP; 2.093A {Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)} Probab=97.21 E-value=4.8e-07 Score=92.12 Aligned_cols=217 Identities=16% Similarity=0.063 Sum_probs=119.7 Template_Neff=11.400 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+ T Consensus 22 ~~~~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~a~~~~g--------~~~~~~~~~~-~~~----~~~~~ 76 (316) T 5XSS_A 22 VEKEPIKPKIVLISHIKTN------------PYWLDIKAGAERAAKERG--------AVVEFLGPTT-AST----EDGLK 76 (316) T ss_dssp ------CCEEEEECSSTTC------------HHHHHHHHHHHHHHHHHT--------CEEEEECCSS-CCH----HHHHH T ss_pred ccCCCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC--------CEEEEeCCCC-CCH----HHHHH Confidence 3456678999999986542 255677788888887753 3444433222 121 12223 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .++.+.. +++|++|. +............+...++|+|..+...+. .++++++.+ T Consensus 77 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~ 131 (316) T 5XSS_A 77 LFDMATS-------------------AKVSGIITYVQEEGQYKKKINSAMEKGIPVVTIDSDEED------SNRIAYVGT 131 (316) T ss_dssp HHHHHHH-------------------TTCSEEEECCCSTTSSHHHHHHHHHTTCCEEEESSCCCS------SCCSEEESB T ss_pred HHHHHHH-------------------cCCCEEEEccCCcchhHHHHHHHHHCCCCEEEEcCCCCC------CCCeEEEeC Confidence 3333332 47787774 333322223444566789999987654321 245677777 Q NP_000836.2 198 PDSYQAQAMVDIVTAL-GW-NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET- 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~-~~-~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~- 272 (908) +....+..+++++.+. +. ++++++.. ++.++..+.++|++.+++.+.+.+....... ....+....++++++. T Consensus 132 d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~ 209 (316) T 5XSS_A 132 DNVLAGQVAGKEMVKQIGTSGNVAIVMGGKNVKNQKERVEGFTQYIKSNSNLKIVDTDSSD--AMLLEAEIITRKILNRN 209 (316) T ss_dssp CHHHHHHHHHHHHHHHHCSSSEEEEEESCTTCHHHHHHHHHHHHHHHHHCCCEEEEEEECT--TCHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHHHCCCceEEEEECCCCchhHHHHHHHHHHHHHhcCCcEEeEEecCc--hHHHHHHHHHHHHHHhC Confidence 7777788888887654 65 88998875 3345667778888877764213332211111 1111233445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 210 ~~~~~i~~~~-~~~a~~~~~al~~~g~~~~~~iig~ 244 (316) T 5XSS_A 210 DNINALFCTS-ALDGIGAARAVKDLNYKDRVKIICF 244 (316) T ss_dssp SCCCEEEECS-HHHHHHHHHHHHHTTCTTTSEEEEE T ss_pred CCcCEEEECC-chhHHHHHHHHHHcCCCCCeEEEEe Confidence 2467776654 3446677778877776323444443 No 206 >4YR7_A LuxP; PROTEIN-LIGAND COMPLEX, QUORUM SENSING, signaling; HET: A1B; 2.533A {Vibrio harveyi} Probab=97.20 E-value=5.1e-07 Score=93.23 Aligned_cols=222 Identities=11% Similarity=0.029 Sum_probs=124.2 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|..+.. ........+++.++++.+. .+.+++.+.|+..++. ...+.++ T Consensus 43 ~~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~~~~~~g~------~~~l~~~~~d~~~~~~----~~~~~~~ 101 (345) T 4YR7_A 43 TQRPIKISVVYPGQQVS-----------DYWVRNIASFEKRLYKLNI------NYQLNQVFTRPNADIK----QQSLSLM 101 (345) T ss_dssp CSSCEEEEEEEECSCSC-----------CHHHHHHHHHHHHHHHTTC------CEEEEEEEECTTCCHH----HHHHHHH T ss_pred CCCCeEEEEEecCCCCC-----------HHHHHHHHHHHHHHHHcCC------cEEEEEeecCCCCCHH----HHHHHHH Confidence 56789999999975322 1334778888888888642 1222224455444322 2333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+.........+.. .++|+|..+...+.... ...++.+++.+++. T Consensus 102 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~ 161 (345) T 4YR7_A 102 EALK-------------------SKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREW-DKHQPFLYVGFDHA 161 (345) T ss_dssp HHHH-------------------TCCSEEEECCCTTTSHHHHHHHHTTCSSEEEEETCCSCBGGG-GGSCCSEEEECCHH T ss_pred HHHH-------------------cCCCEEEEeCCchhhHHHHHHHHHhCCCeEEEEcCCCCcchh-ccCCCeEEEEcChH Confidence 4332 478888876543333333444444 79999987654432111 11346677888888 Q NP_000836.2 201 YQAQAMVDIVTALGWN--YVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~--~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..++.+++++.+.+.+ +++++..+ +.++..+.++|++.+++.+++++....... .+..+....+++++.. .+++ T Consensus 162 ~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ 239 (345) T 4YR7_A 162 EGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTK--ATKQSGYDAAKASLAKHPDVD 239 (345) T ss_dssp HHHHHHHHHHHHHSCTTCEEEEECCSTTHHCCCCCCHHHHHHHHHHCCEEEEEECCC--SSHHHHHHHHHHHHHHCCCCS T ss_pred HHHHHHHHHHHHhCCCCCeEEEEEecCCchhHHHHHHHHHHHHhcCCceEeeccccC--CCHHHHHHHHHHHHHHCCCCc Confidence 8888888887654443 48888754 446667778888877653223333211111 1122344455555431 2345 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|++. ++..+..+++++++.|. .++.+++. T Consensus 240 ~i~~~-~~~~a~~~~~al~~~g~-~~i~i~g~ 269 (345) T 4YR7_A 240 FIYAC-STDVALGAVDALAELGR-EDIMINGW 269 (345) T ss_dssp EEEES-SHHHHHHHHHHHHHHTC-TTSEEBCS T ss_pred EEEEC-ChHHHHHHHHHHHHcCC-CCcEEEee Confidence 55544 34455667888887776 23344443 No 207 >2IOY_A Periplasmic sugar-binding proteins; Ribose binding protein, sugar binding; HET: RIP; 1.9A {Thermoanaerobacter tengcongensis} Probab=97.19 E-value=5.3e-07 Score=89.96 Aligned_cols=208 Identities=13% Similarity=0.145 Sum_probs=116.2 Template_Neff=11.900 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) .+||++.|..+. .++.....+++.++++.+ +++.+.++..++. ...+.++++.. T Consensus 2 ~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~l~~~~~~~~~~----~~~~~~~~l~~ 55 (283) T 2IOY_A 2 KTIGLVISTLNN------------PFFVTLKNGAEEKAKELG----------YKIIVEDSQNDSS----KELSNVEDLIQ 55 (283) T ss_dssp CEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHHHHH T ss_pred cEEEEEecCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEECCCCCHH----HHHHHHHHHHh Confidence 578999986542 245667778877777642 3344455433322 22233333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) ++++++|. +..+.........+...++|+|..+...+. .++.+++.++....++ T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 110 (283) T 2IOY_A 56 -------------------QKVDVLLINPVDSDAVVTAIKEANSKNIPVITIDRSANG------GDVVCHIASDNVKGGE 110 (283) T ss_dssp -------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCCSEEEEECHHHHHH T ss_pred -------------------CCCCEEEECCCChhHHHHHHHHHHHCCCCEEEEcCCCCC------CCeEEEEecChHHHHH Confidence 46776665 333322223344456689999987754321 2456677777777788 Q NP_000836.2 205 AMVDIVTA--LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVI 279 (908) Q Consensus 205 ~~~~~l~~--~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv 279 (908) .+++++.+ .+.++++++.. ++.++..+.++|++.+++.++..+....... .+..+....++++++ ..++|+|+ T Consensus 111 ~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~i~ 188 (283) T 2IOY_A 111 MAAEFIAKALKGKGNVVELEGIPGASAARDRGKGFDEAIAKYPDIKIVAKQAAD--FDRSKGLSVMENILQAQPKIDAVF 188 (283) T ss_dssp HHHHHHHHHTTTCEEEEEEECCTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCSCCCEEE T ss_pred HHHHHHHHHcCCCeEEEEEECCCCChhHHHHHHHHHHHHHhCCCeEEEEeecCC--CCHHHHHHHHHHHHHHCCCCCEEE Confidence 88888765 47789999974 3455667778888877664223332111111 111233344445432 13577776 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +.. +..+..+++++++.|.. ++.+++. T Consensus 189 ~~~-~~~a~~~~~~l~~~g~~-~~~iig~ 215 (283) T 2IOY_A 189 AQN-DEMALGAIKAIEAANRQ-GIIVVGF 215 (283) T ss_dssp ESS-HHHHHHHHHHHHHTTCC-CCEEEEE T ss_pred EcC-hhHHHHHHHHHHHcccC-CcEEEEe Confidence 654 34566677777776652 2344443 No 208 >1TLF_C TRYPTIC CORE FRAGMENT OF THE; TRANSCRIPTION REGULATION; HET: IPT, EMC; 2.6A {Escherichia coli} SCOP: c.93.1.1 Probab=97.19 E-value=5.3e-07 Score=91.01 Aligned_cols=200 Identities=12% Similarity=0.076 Sum_probs=116.5 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ +++.+...+. .+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~a~~~~g--------~~l~~~~~~~-~~~----~~~~~~~~~l~ 56 (301) T 1TLF_C 2 SLLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVHNLL 56 (301) T ss_dssp CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------CEEEEEECCS-SSH----HHHHHHHHHHH T ss_pred CceEEEEeCcccc------------chHHHHHHHHHHHHHHcC--------CEEEEEecCC-CcH----HHHHHHHHHHH Confidence 5789999997542 255677788888887753 3333332221 111 12233444433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . .+++++|+...+.........+...++|+|..+...+ +.++.+.++....+. T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~~~~ 109 (301) T 1TLF_C 57 A-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHEDGTR 109 (301) T ss_dssp T-------------------TTCSEEEEESCCCHHHHHHHHHHSTTSCEEESSSCTT--------SSSEEEEECHHHHHH T ss_pred h-------------------CCCCEEEEeCCCCchHHHHHHHHHcCCCEEEEeCCCC--------CCCCeEEeccHHHHH Confidence 2 4788888765443322222235678999988765332 234556666666677 Q NP_000836.2 205 AMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMF 281 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~ 281 (908) .+++++.+.+.++++++.. +..+...+.++|++.+++. ++++....... .+..+....+++++.. .++|+|++. T Consensus 110 ~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~daii~~ 186 (301) T 1TLF_C 110 LGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAMLVA 186 (301) T ss_dssp HHHHHHHHHTCCSEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSEEEES T ss_pred HHHHHHHHCCCCeEEEEeCCCCCHHHHHHHHHHHHHHHHC-CCCCeeeecCC--CChHHHHHHHHHHHHcCCCCCEEEEC Confidence 7788776668889999985 3345666778888888775 35443211111 1112233445555421 247788766 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~ 300 (908) . +..+..+++++++.|+. T Consensus 187 ~-~~~a~~~~~~l~~~g~~ 204 (301) T 1TLF_C 187 N-DQMALGAMRAITESGLR 204 (301) T ss_dssp S-HHHHHHHHHHHHHTTCC T ss_pred C-hHHHHHHHHHHHHcCCC Confidence 4 44567788888877764 No 209 >3OQO_C Catabolite control protein A, Phosphocarrier; pbp fold for ccpa, transcription; HET: SEP, SO4; 2.97A {Bacillus subtilis} Probab=97.19 E-value=5.3e-07 Score=92.84 Aligned_cols=204 Identities=9% Similarity=0.065 Sum_probs=119.3 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++.....+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 57 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 110 (339) T 3OQO_C 57 SKKTTTVGVIIPDISS------------IFYSELARGIEDIATMYK--------Y--NIILSNSDQNM----EKELHLLN 110 (339) T ss_dssp HTCCSEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 4578899999997542 255677788888877642 2 23334433332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.. ......+...++|+|..+...+ .+..+.+.+++.. T Consensus 111 ~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~~~~~ 163 (339) T 3OQO_C 111 TMLG-------------------KQVDGIVFMGGNIT-DEHVAEFKRSPVPIVLAASVEE-------QEETPSVAIDYEQ 163 (339) T ss_dssp HHHH-------------------TTCSEEEECCSCCC-HHHHHHHTTCSSCEEEESCCCT-------TCCSCEEECCHHH T ss_pred HHhc-------------------CCCCEEEEcCCCCC-HHHHHHHHhCCCCEEEEcCCCC-------CCCCCEEEcCHHH Confidence 3332 47888887544333 3444556678999998765432 1345566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNYG---ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~~---~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .++.+++++.+.+.++++++..+.... ..+.++|++.+++. ++.+........+.+..+....+++++. ..++|+ T Consensus 164 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~ 242 (339) T 3OQO_C 164 AIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEA-NLPFNEQFVAEGDYTYDSGLEALQHLMSLDKKPTA 242 (339) T ss_dssp HHHHHHHHHHTTSCSSEEEEECCTTSHHCCCCCCHHHHHHHHTT-TCCCCGGGEEECCSCHHHHHHHHHHHHHSSSCCSE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCCCCcccHHHHHHHHHHHHHHC-CCCcChhheecCCCChhHHHHHHHHHhhcCCCCCE Confidence 777888888767888999998544322 45677888877764 3443211111100112233344555542 146788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 243 i~~~~-~~~a~~~~~~l~~~g~~ 264 (339) T 3OQO_C 243 ILSAT-DEMALGIIHAAQDQGLS 264 (339) T ss_dssp EEESS-HHHHHHHHHHHHTTSCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 87664 44556677788777763 No 210 >4RK6_A Glucose-resistance amylase regulator; sugar binding, transcription regulation, Enzyme; HET: MSE, GLC; 1.76A {Weissella paramesenteroides ATCC 33313} Probab=97.19 E-value=5.4e-07 Score=90.02 Aligned_cols=205 Identities=10% Similarity=0.066 Sum_probs=115.0 Template_Neff=12.100 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.| +++.+.+...+. +...+. T Consensus 5 l~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~ 58 (287) T 4RK6_A 5 LSSKRSRVVGVVVPLIHT------------NFADEIIKGLYETTISSG----------YELLITYLDEDE----DHQYQV 58 (287) T ss_dssp ------CEEEEEEESSCC------------THHHHHHHHHHHHHHHHT----------CEEEEEEECSCH----HHHHHH T ss_pred hhcCCCCeEEEEecCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEECCCCH----HHHHHH Confidence 344578899999996542 255667778887776643 233444443332 223334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++.. ++++++|+...+... .....+...++|+|..+...+ +.++++.++. T Consensus 59 ~~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~ 110 (287) T 4RK6_A 59 FQTLLS-------------------RQVGAVFMLSLDIPS-WMIDKLLEEQISVISLTALLS--------EQISAVTSNE 110 (287) T ss_dssp HHHHHH-------------------TTCSEEEECCSCCCH-HHHHHHHHTTCEEEEESSCCC--------TTSEEEEECH T ss_pred HHHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEeCcccC--------CCCCEEEeCH Confidence 444332 478888875443332 344556677999988765332 2455666677 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPN 274 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~ 274 (908) ...++.+++++.+.+.++++++..+.. ++..+.++|++.+++. +..+..........+..+....+++++ ...+ T Consensus 111 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 189 (287) T 4RK6_A 111 FEMMNSIVDYLIDMGHKNIALVGDTKLTTNISSTRRTNFIKSMTDH-NLAYENIFLYGNDHSYETGYTSVTTGYDINQLP 189 (287) T ss_dssp HHHHHHHHHHHHHTTCCSEEEESBCCCCSSSCCHHHHHHHHHHHHT-TCCGGGEEEECBSSCHHHHHHCCCCCSCTTSCS T ss_pred HHHHHHHHHHHHHCCCCcEEEEcCCccCCcccHHHHHHHHHHHHHC-CCCcceeEecCCCCChhhhhHHHHhhhhhCCCC Confidence 777778888876667889999985432 5566778888877764 343221111110011122333344432 1236 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++|++.. +..+..+++++++.|+. T Consensus 190 ~~~i~~~~-~~~a~~~~~~l~~~g~~ 214 (287) T 4RK6_A 190 FTAAIATA-DMVGQGLINAMSDHGKT 214 (287) T ss_dssp CSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCEEEEcC-cHHHHHHHHHHHHcCCC Confidence 77776654 44566778888877764 No 211 >4RK7_B Glucose-resistance amylase regulator; sugar binding, transcription regulation, Enzyme; HET: MSE, SUC; 1.8A {Weissella paramesenteroides ATCC 33313} Probab=97.19 E-value=5.4e-07 Score=90.02 Aligned_cols=205 Identities=10% Similarity=0.066 Sum_probs=115.0 Template_Neff=12.100 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.| +++.+.+...+. +...+. T Consensus 5 l~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~ 58 (287) T 4RK7_B 5 LSSKRSRVVGVVVPLIHT------------NFADEIIKGLYETTISSG----------YELLITYLDEDE----DHQYQV 58 (287) T ss_dssp ------CEEEEEEESSCC------------THHHHHHHHHHHHHHHTT----------CEEEEEEECSCH----HHHHHH T ss_pred hhcCCCCeEEEEecCCCC------------hhHHHHHHHHHHHHHHcC----------CEEEEEECCCCH----HHHHHH Confidence 344578899999996542 255667778887776643 233444443332 223334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++++.. ++++++|+...+... .....+...++|+|..+...+ +.++++.++. T Consensus 59 ~~~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~ 110 (287) T 4RK7_B 59 FQTLLS-------------------RQVGAVFMLSLDIPS-WMIDKLLEEQISVISLTALLS--------EQISAVTSNE 110 (287) T ss_dssp HHHHHT-------------------TTCSEEEECCTTCCH-HHHHHHHHTTCEEEEESSCCC--------TTSEEEEECH T ss_pred HHHHHh-------------------CCCCEEEEecCCCCH-HHHHHHHhCCCcEEEeCcccC--------CCCCEEEeCH Confidence 444332 478888875443332 344556677999988765332 2455666677 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPN 274 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~ 274 (908) ...++.+++++.+.+.++++++..+.. ++..+.++|++.+++. +..+..........+..+....+++++ ...+ T Consensus 111 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~ 189 (287) T 4RK7_B 111 FEMMNSIVDYLIDMGHKNIALVGDTKLTTNISSTRRTNFIKSMTDH-NLAYENIFLYGNDHSYETGYTSVTTGYDINQLP 189 (287) T ss_dssp HHHHHHHHHHHHHTTCCSEEEESBCCCCSSSCCHHHHHHHHHHHHT-TCCGGGEEEECBSSCHHHHHHCCCCCSCTTSCS T ss_pred HHHHHHHHHHHHHCCCCcEEEEcCCccCCcccHHHHHHHHHHHHHC-CCCcceeEecCCCCChhhhhHHHHhhhhhCCCC Confidence 777778888876667889999985432 5566778888877764 343221111110011122333344432 1236 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++|++.. +..+..+++++++.|+. T Consensus 190 ~~~i~~~~-~~~a~~~~~~l~~~g~~ 214 (287) T 4RK7_B 190 FTAAIATA-DMVGQGLINAMSDHGKT 214 (287) T ss_dssp CSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCEEEEcC-cHHHHHHHHHHHHcCCC Confidence 77776654 44566778888877764 No 212 >4RWE_A Sugar-binding transport protein; structural genomics, The Center for; 1.65A {Yersinia pestis} Probab=97.17 E-value=6e-07 Score=89.98 Aligned_cols=213 Identities=12% Similarity=0.043 Sum_probs=120.4 Template_Neff=12.000 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .+.++||++.|..+. .++.....+++.++++.| |..+++.+.++..++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~-------g~~~~~~~~~~~~~~~----~~~~~~~~ 59 (292) T 4RWE_A 3 AELNSIGVTVGDLAN------------PFFVQITKGVELEARKLA-------GDKVKVTLVSSGYDLG----QQVAQIDN 59 (292) T ss_dssp -CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHH-------CTTCEEEEEECTTCHH----HHHHHHHH T ss_pred cccceEEEEecccCC------------HHHHHHHHHHHHHHHHHc-------CCceEEEEecCCCCHH----HHHHHHHH Confidence 467899999997542 256678888888888765 2345555556544322 22333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+...+.. .......+...++|+|..+...+ ++.+++.+++.. T Consensus 60 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 112 (292) T 4RWE_A 60 FIA-------------------AKVDMIILNAADSKGIGPAVKRAKDAGIVVVAVDVAAE--------GADATITSDNTQ 112 (292) T ss_dssp HHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCT--------TCSEEEEECHHH T ss_pred HHH-------------------CCCCEEEEeCCCccchHHHHHHHHHCCCEEEEEcCCCC--------CCceEEecCHHH Confidence 332 46787776443322 22334455667999998765432 135566677777 Q NP_000836.2 202 QAQAMVDIVTALG--WNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~--~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+ .++++++.. ...++..+.++|++.+++.+++.+....... ..+..+....++++++. .++++ T Consensus 113 ~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~ 191 (292) T 4RWE_A 113 AGAMACKYISDRLKEKGNVVIINGPPVSAIQNRVEGCESEFKKYPDIKVLSSNQNA-KGSREGGLEVMTSLLAVNPKIDG 191 (292) T ss_dssp HHHHHHHHHHHHTTTEEEEEEEBCCSSHHHHHHHHHHHHHHTTCTEEEEEECCCBC-TTSHHHHHHHHHHHHHHCSCCCE T ss_pred HHHHHHHHHHHHhCCCceEEEEeCCCChHHHHHHHHHHHHHHHCCCcEEEeeccCC-CCcHHHHHHHHHHHHHhCCCCCE Confidence 7778888775543 778998884 3345556677788777664223332211000 01112233445555421 24566 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|.. ++.+++. T Consensus 192 i~~~~-~~~a~~~~~~~~~~g~~-~~~i~~~ 220 (292) T 4RWE_A 192 VFAIN-DPTAIGADLAAKQAQRN-EFFIVGV 220 (292) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC-SSEEECS T ss_pred EEEcC-ChHHHHHHHHHHHcCCC-CeEEEEe Confidence 66553 44566777788777642 3344443 No 213 >3GV0_A Transcriptional regulator, LacI family; Transcription regulator, PSI-II, 11224e, Structural; 2.35A {Agrobacterium tumefaciens str.} Probab=97.16 E-value=6.1e-07 Score=89.81 Aligned_cols=207 Identities=8% Similarity=0.078 Sum_probs=116.3 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++.++||++.|.++.. ..++..+..+++.++++.+ ++ +.+.+...+.. .. ..+ T Consensus 4 ~~~~~~~Ig~~~~~~~~~----------~~~~~~~~~~~~~~~~~~g--------~~--~~~~~~~~~~~----~~-~~~ 58 (288) T 3GV0_A 4 RTGKTNVIALVLSVDEEL----------MGFTSQMVFGITEVLSTTQ--------YH--LVVTPHIHAKD----SM-VPI 58 (288) T ss_dssp ---CCCEEEEECBCCCCS----------SCHHHHHHHHHHHHHTTSS--------CE--EEECCBSSGGG----TT-HHH T ss_pred CCCCccEEEEEeecchHc----------ChHHHHHHHHHHHHHHhcC--------cE--EEEEecCCCcc----cc-hhH Confidence 345689999999975321 1245667788888877642 33 33344332211 11 112 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) .+.+. .+++|++|+...+... .....+...++|+|.++...+ .+..+.+..++. T Consensus 59 ~~~~~------------------~~~~d~ii~~~~~~~~-~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~ 112 (288) T 3GV0_A 59 RYILE------------------TGSADGVIISKIEPND-PRVRFMTERNMPFVTHGRSDM-------GIEHAFHDFDNE 112 (288) T ss_dssp HHHHH------------------HTCCSEEEEESCCTTC-HHHHHHHHTTCCEEEESCCCS-------SCCCEEEEECHH T ss_pred HHHHH------------------hCCCCEEEEeCCCCCC-HHHHHHHHcCCCEEEeCCCCC-------CCCCcEEecCcH Confidence 22111 1578888876544333 444556678999998776432 123455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGNY--GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~~--~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++..+..+ ...+.++|++.+++. ++.+........+.+..+....+++++. ..++|+ T Consensus 113 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~ 191 (288) T 3GV0_A 113 AYAYEAVERLAQCGRKRIAVIVPPSRFSFHDHARKGFNRGIRDF-GLTEFPIDAVTIETPLEKIRDFGQRLMQSSDRPDG 191 (288) T ss_dssp HHHHHHHHHHHHTTCCEEEEECCCTTSHHHHHHHHHHHHHHHHT-TCEECCCCSCCTTSCHHHHHHHHHHHTTSSSCCSE T ss_pred HHHHHHHHHHHHCCCCeEEEECCCCCCchHHHHHHHHHHHHHHc-CCCCCCceeEEeCCCHHHHHHHHHHHHccCCCCCE Confidence 677778888766788899999864433 445677888877764 3433221001100111233344555532 236788 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 192 i~~~~-~~~a~~~~~~l~~~g~~ 213 (288) T 3GV0_A 192 IVSIS-GSSTIALVAGFEAAGVK 213 (288) T ss_dssp EEESC-HHHHHHHHHHHHTTTCC T ss_pred EEEcC-HHHHHHHHHHHHHcCCC Confidence 77664 44566778888877764 No 214 >5HKO_A ABC transporter, carbohydrate uptake transporter-2; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: ACT, 62W, IMD, ZN; 1.2A {Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)} Probab=97.16 E-value=6.3e-07 Score=92.68 Aligned_cols=214 Identities=13% Similarity=0.076 Sum_probs=118.8 Template_Neff=10.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|... .++.....+++.++++.+ +++.+.|...+.. ...+. T Consensus 28 ~~~~~~~~Ig~v~~~~~-------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~ 80 (348) T 5HKO_A 28 AANSDTKRIGVTVYDMS-------------SFITEGKEGMDTYAKANN----------IELVWNSANNDVS----TQASQ 80 (348) T ss_dssp -----CEEEEEEESCCC-------------HHHHHHHHHHHHHHHHTT----------EEEEEEECTTCHH----HHHHH T ss_pred cccCCCcEEEEEECCCC-------------HHHHHHHHHHHHHHHHCC----------CEEEEecCCCCHH----HHHHH Confidence 45567899999998652 245566777777776642 3444555443321 22233 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++++|....+.. .......+...++|+|..+...+. .++++++.++ T Consensus 81 i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 135 (348) T 5HKO_A 81 VDSLIN-------------------QGVDAIIVVPVQADSLGPQVASAKSKGIPLLAVNAALET------PDLAGNVQPD 135 (348) T ss_dssp HHHHHH-------------------TTCSEEEEECSCSSCCHHHHHHHHHTTCCEEEESSCCCC------TTCSEEEEEC T ss_pred HHHHHH-------------------CCCCEEEEeCCCccccHHHHHHHHHCCCCEEEEcCCCCC------CCCceEEcCC Confidence 343332 46787776443322 223445566789999987654321 2345677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...++.+++++.+. +.++++++.. ++.+...+.++|++.+++.+++.+....... .+..+....+++++.. T Consensus 136 ~~~~g~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 213 (348) T 5HKO_A 136 DVAAGAQEMQMMADRLGGKGNIVILQGPLGGSGEINRGKGIDQVLAKYPDIKVLAKDTAN--WKRDEAVNKMKNWISSFG 213 (348) T ss_dssp HHHHHHHHHHHHHHHHTTCEEEEEEECSTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred HHHHHHHHHHHHHHHhCCCcEEEEEECCCCChHHHHHHHHHHHHHHhCCCcEEEEeecCC--CCHHHHHHHHHHHHHHhC Confidence 777777888877544 6788999885 3345566777888877663223332111111 1112333445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) .++|+|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 214 ~~~d~I~~~~-d~~a~~~~~al~~~g~~-~i~iig~d 248 (348) T 5HKO_A 214 PQIDGVVAQN-DDMGLGALQALKEAGRT-GVPIVGID 248 (348) T ss_dssp GGCCEEEESS-HHHHHHHHHHHHHTTCC-SCCEECSB T ss_pred CCCCEEEECC-hHHHHHHHHHHHHcCCC-CCCEEEec Confidence 2477777664 44566778888877763 33444443 No 215 >4RXU_A Periplasmic sugar-binding protein; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: BGC, CIT; 1.4A {Chloroflexus aurantiacus} Probab=97.15 E-value=6.5e-07 Score=93.42 Aligned_cols=153 Identities=17% Similarity=0.075 Sum_probs=91.9 Template_Neff=10.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. .++..+..+++.++++.| +++.+.|...+. +...+ T Consensus 24 ~~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~----~~~~~ 77 (367) T 4RXU_A 24 STGNTQQLAVGIVLPTKDE------------PRWIQDETRFREALQQAG----------YQVEILFSQGSS----AKEKE 77 (367) T ss_dssp ----CEEEEEEEEESCSSS------------THHHHHHHHHHHHHHHHT----------EEEEEEECTTCH----HHHHH T ss_pred CCCCCCCeEEEEEeCCCCC------------hHHHhHHHHHHHHHHHcC----------CEEEEEecCCCH----HHHHH Confidence 3456678999999997542 255677788888887753 344445544332 22333 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGA-AASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~-~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|.. ..+.........+...++|+|..+...+. ..++.+++.+ T Consensus 78 ~i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvi~~~~~~~~-----~~~~~~~v~~ 133 (367) T 4RXU_A 78 NVEALIA-------------------KGIKVLIICPHDGTAAAAAAEAARAAGVKVISYDRLIRE-----TDAVDYYVTF 133 (367) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCS-----CSCCCEEEEE T ss_pred HHHHHHH-------------------cCCCEEEEcCCChhHHHHHHHHHHHCCCEEEEecCCCCC-----CCCccEEEEc Confidence 3444332 467766643 33333334455567789999987764432 1244567777 Q NP_000836.2 198 PDSYQAQAMVDIVTAL--GWNYVSTLA---SEGNYGESGVEAFTQISRE 241 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~--~~~~v~ii~---~~~~~~~~~~~~~~~~~~~ 241 (908) ++...++.+++++.+. +.++++++. .++.+...+.++|++.+++ T Consensus 134 d~~~~g~~~~~~l~~~~~g~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~ 182 (367) T 4RXU_A 134 DSIAVGAQQAQYLVDHASGTGNPLYLYAGAASDNNAFLFFEGAWKVLQP 182 (367) T ss_dssp CHHHHHHHHHHHHHHTCCSSCEEEEECBCCTTSHHHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHccCCCCcEEEEecCCCChhHHHHHHHHHHHHHH Confidence 7777788888887654 778899886 2334555666677666654 No 216 >4KMR_A Transcriptional regulator, LacI family; Structural Genomics, PSI-Biology, Midwest Center; 1.45A {Sanguibacter keddieii} Probab=97.14 E-value=6.7e-07 Score=88.91 Aligned_cols=201 Identities=12% Similarity=0.072 Sum_probs=113.6 Template_Neff=12.100 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +..+||++.|..+. .++.....+++.++++.| +.+.+.|+..++. ...+.++++ T Consensus 2 ~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~~ 55 (280) T 4KMR_A 2 RSGVIGLAVPELGQ------------AFFAQLADEVIRVAAEQD----------LVVLVEQTGGLRE----RELEALRNP 55 (280) T ss_dssp CCSEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT----------CEEEEEECTTCHH----HHHHHHHCG T ss_pred CcceEEEEeCccch------------HHHHHHHHHHHHHHHHCC----------CEEEEEecCCchH----HHHHHHHhh Confidence 46789999987542 256678888888887763 2334445433321 222333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) +. +++|++|+...+..... ..+...++|+|..+...+ .++.+.+.+++...+ T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~~~--~~~~~~~ip~v~~~~~~~-------~~~~~~v~~d~~~~~ 107 (280) T 4KMR_A 56 RL-------------------SLTDGLLLAPLGLTQDD--VLPDPAGRPLVVLGEPLF-------PGPVDHVTMQHEAAA 107 (280) T ss_dssp GG-------------------TTCSCEEECCSSCC-CC--C------CCEEEESSSCC-------CSSCEEECCCHHHHH T ss_pred HH-------------------hcCCEEEEecCCCCCcc--cCcCcCCCcEEEECCCCC-------CCCCCEEEcCHHHHH Confidence 32 47888876544332221 234678999998776432 134566677777777 Q NP_000836.2 204 QAMVDIVTALGWNYVSTLASEG----NYGESGVEAFTQISREIGGVCIAQSQKIP-REPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 204 ~~~~~~l~~~~~~~v~ii~~~~----~~~~~~~~~~~~~~~~~~~i~v~~~~~~~-~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) +.+++++.+.+.++++++..+. .++..+.+++++.+++. ++.+.....+. ...+..+....++++++ ..++++ T Consensus 108 ~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 186 (280) T 4KMR_A 108 RAATEHLLGLGRRRVMLLGAHATERTGVAALRYAGYREALTAA-GLAVDDDLVVPVETWDRSSGAEAMARVLDAGVRMDA 186 (280) T ss_dssp HHHHHHHHHTTCCCEEEETSCSSCCCHHHHHHHHHHHHHHHHT-TCCCCGGGEECCSSCSHHHHHHHHHHHHHTTCCCSE T ss_pred HHHHHHHHHCCCCeEEEEecCcccCchhHHHHHHHHHHHHHHc-CCCCCCCeEeecCCCChhHHHHHHHHHHHcCCCCCE Confidence 7888888767889999998543 35566778888888765 34433211111 00111223344455442 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 187 i~~~~-~~~a~~~~~~~~~~g~~ 208 (280) T 4KMR_A 187 VFAMN-DDLALGALRSLQERGVA 208 (280) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888877764 No 217 >3L6U_A ABC-TYPE SUGAR TRANSPORT SYSTEM PERIPLASMIC; structural genomics, NYSGRC, target 11006s; HET: MSE, SO4; 1.9A {Exiguobacterium sibiricum} Probab=97.14 E-value=6.8e-07 Score=89.71 Aligned_cols=205 Identities=11% Similarity=0.062 Sum_probs=114.7 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|..+. .++.....+++.++++.+ +++.+.+...++. ...+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~~ 58 (293) T 3L6U_A 5 SPKRNIVGFTIVNDKH------------EFAQRLINAFKAEAKANK----------YEALVATSQNSRI----SEREQIL 58 (293) T ss_dssp ----CEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECSSCHH----HHHHHHH T ss_pred CCCCcEEEEEECCCCC------------HHHHHHHHHHHHHHHHCC----------CeEEEecCCCCHH----HHHHHHH Confidence 4567899999987542 245667788888877652 2344444433321 2223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. +++|++|+...+... ......+...++|+|..+...+. .++++++.+++. T Consensus 59 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 113 (293) T 3L6U_A 59 EFVH-------------------LKVDAIFITTLDDVYIGSAIEEAKKAGIPVFAIDRMIRS------DAVVSSITSNNQ 113 (293) T ss_dssp HHHH-------------------TTCSEEEEECSCTTTTHHHHHHHHHTTCCEEEESSCCCC------TTCSEEEEECHH T ss_pred HHHh-------------------cCCCEEEEecCCcchHHHHHHHHHHcCCCEEEEcCCCCC------CccceEEecChH Confidence 3332 478888765433322 24445566789999987654321 245667777777 Q NP_000836.2 201 YQAQAMVDIVTAL-------GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 201 ~~~~~~~~~l~~~-------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) ..++.+++++.+. +.++++++.. +..++..+.+++++.+++.+.+.+....... .+..+....++++++ T Consensus 114 ~~~~~~~~~l~~~~~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 191 (293) T 3L6U_A 114 MIGEQLASYIKNELIKQTGRSTGRIVEITGTANVYTTNERHRGFLKGIENEPTLSIVDSVSGN--YDPVTSERVMRQVID 191 (293) T ss_dssp HHHHHHHHHHHHHHHHHHSCSCEEEEEEECSTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHhCCCceEEEEEEcCCCChhHHHHHHHHHHHHHhCCCceEEeeeeCC--CCHHHHHHHHHHHHH Confidence 7777777776432 4578988875 3345666777888877664222332111111 111223344455542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) . .++++|++.. +..+..+++++++.|+. T Consensus 192 ~~~~~~~i~~~~-~~~a~~~~~al~~~g~~ 220 (293) T 3L6U_A 192 SGIPFDAVYCHN-DDIAMGVLEALKKAKIS 220 (293) T ss_dssp TTCCCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred hCCCCCEEEECC-hHHHHHHHHHHHHCCCC Confidence 1 2477777664 44566778888877764 No 218 >2DRI_A D-RIBOSE-BINDING PROTEIN COMPLEXED WITH BETA-D-RIBOSE; SUGAR TRANSPORT; HET: RIP; 1.6A {Escherichia coli} SCOP: c.93.1.1 Probab=97.14 E-value=6.8e-07 Score=88.20 Aligned_cols=207 Identities=14% Similarity=0.114 Sum_probs=116.2 Template_Neff=12.400 Q NP_000836.2 46 IILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIE 125 (908) Q Consensus 46 i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~~ 125 (908) .+||++.|..+. ..+.....+++.++++.| +++.+.|+..+.. ...+.++++.. T Consensus 2 ~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~~~~ 55 (271) T 2DRI_A 2 DTIALVVSTLNN------------PFFVSLKDGAQKEADKLG----------YNLVVLDSQNNPA----KELANVQDLTV 55 (271) T ss_dssp CEEEEEESCSSS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCHH----HHHHHHHHHTT T ss_pred CeEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHHHHHHH Confidence 478888887542 255677788888887753 3344455433321 22233333332 Q NP_000836.2 126 KDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 126 ~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) +++++++ ++..+.........+.+.++|+|..+...+. .++++++.+++...++ T Consensus 56 -------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~------~~~~~~v~~d~~~~~~ 110 (271) T 2DRI_A 56 -------------------RGTKILLINPTDSDAVGNAVKMANQANIPVITLDRQATK------GEVVSHIASDNVLGGK 110 (271) T ss_dssp -------------------TTEEEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCSS------SCCSEEEEECHHHHHH T ss_pred -------------------CCCCEEEEecCCcchHHHHHHHHHHCCCCEEEEcCCCCC------CceEEEEEeCcHHHHH Confidence 3566554 4433333334445567789999987754321 2456777777777788 Q NP_000836.2 205 AMVDIVTALGW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVI 279 (908) Q Consensus 205 ~~~~~l~~~~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv 279 (908) .+++++.+.+. .+++++.. +..++..+.+++++.+++. ++++....... .+..+....+++++.. .++++|+ T Consensus 111 ~~~~~l~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~~i~ 187 (271) T 2DRI_A 111 IAGDYIAKKAGEGAKVIELQGIAGTSAARERGEGFQQAVAAH-KFNVLASQPAD--FDRIKGLNVMQNLLTAHPDVQAVF 187 (271) T ss_dssp HHHHHHHHHHCTTCEEEEEECCTTCHHHHHHHHHHHHHHHHH-TCEEEEEEECT--TCHHHHHHHHHHHHHHCTTCCEEE T ss_pred HHHHHHHHHhCCCceEEEEEcCCCChhHHHHHHHHHHHHHhc-CceEEEeecCC--CcHHHHHHHHHHHHHHCCCCCEEE Confidence 88888755432 35666652 3445667778888888775 35543221111 1122344445555421 2477776 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +.. +..+..+++++++.|.. ++.+++. T Consensus 188 ~~~-~~~~~~~~~~~~~~g~~-~~~i~~~ 214 (271) T 2DRI_A 188 AQN-DEMALGALRALQTAGKS-DVMVVGF 214 (271) T ss_dssp ESS-HHHHHHHHHHHHHHTCC-SCEEEEE T ss_pred eCC-HHHHHHHHHHHHHcCCC-CcEEEEe Confidence 654 34466777888777652 3344443 No 219 >3D02_A Putative LACI-type transcriptional regulator; YP_001338366.1, periplasmic sugar-binding protein, Structural; HET: GOL; 1.3A {Klebsiella pneumoniae subsp. pneumoniae} Probab=97.14 E-value=6.9e-07 Score=90.14 Aligned_cols=214 Identities=13% Similarity=0.071 Sum_probs=117.2 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .++++||++.|..+. .++.....+++.++++++ +++.+. .+...++ ....+.+++ T Consensus 2 ~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~-~~~~~~~----~~~~~~~~~ 56 (303) T 3D02_A 2 AAEKTVVNISKVDGM------------PWFNRMGEGVVQAGKEFN--------LNASQV-GPSSTDA----PQQVKIIED 56 (303) T ss_dssp --CEEEEEECSCSSC------------HHHHHHHHHHHHHHHHTT--------EEEEEE-CCSSSCH----HHHHHHHHH T ss_pred CCceEEEEEeCCCCC------------hHHHHHHHHHHHHHHHcC--------CEEEEe-CCCCCCH----HHHHHHHHH Confidence 357899999997542 255677888888888763 344443 2332332 223334444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGA-AASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~-~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+. ..+.........+...++|+|......+. .++++++..+... T Consensus 57 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~~~~~~~~ 111 (303) T 3D02_A 57 LIA-------------------RKVDAITIVPNDANVLEPVFKKARDAGIVVLTNESPGQP------SANWDVEIIDNEK 111 (303) T ss_dssp HHH-------------------TTCSEEEECCSCHHHHHHHHHHHHHTTCEEEEESCTTCT------TCSEEEESSCHHH T ss_pred HHH-------------------CCCCEEEECCCCccchHHHHHHHHHCCCEEEEeCCCCCC------ccceeEeeeChHH Confidence 332 467877753 33333334455566789999987654321 2345556666666 Q NP_000836.2 202 QAQAMVDIVTA-LGW-NYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLET-PNA 275 (908) Q Consensus 202 ~~~~~~~~l~~-~~~-~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~ 275 (908) .+..+++++.+ .+. ++++++.. ++.++..+.++|++.+++.+ ++++.... .....+..+....+++++.. .++ T Consensus 112 ~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~ 190 (303) T 3D02_A 112 FAAEYVEHMAKRMGGKGGYVIYVGSLTVPQHNLWADLLVKYQKEHYPDMHEVTRR-MPVAESVDDSRRTTLDLMKTYPDL 190 (303) T ss_dssp HHHHHHHHHHHHTTTCEEEEEECSCSSCHHHHHHHHHHHHHHHHHCTTEEESSSC-BSCTTCHHHHHHHHHHHHHHCTTE T ss_pred HHHHHHHHHHHHhCCCeeEEEEECCCCChhHHHHHHHHHHHHHHHCCCceEeecc-CCCCCCHHHHHHHHHHHHHHCCCc Confidence 67777777654 366 68998875 33455667778877776531 23332211 01001112333445555421 245 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|...++.+++. T Consensus 191 ~~i~~~~-~~~a~~~~~a~~~~g~~~~~~v~~~ 222 (303) T 3D02_A 191 KAVVSFG-SNGPIGAGRAVKEKRAKNKVAVYGM 222 (303) T ss_dssp EEEEESS-TTHHHHHHHHHHHTTCTTTCEEEEC T ss_pred cEEEEeC-CCchHHHHHHHHHhccCCCeEEEEe Confidence 6665543 4455668888888776323444443 No 220 >4WZZ_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: RAM, EDO, MSE; 1.7A {Clostridium phytofermentans} Probab=97.13 E-value=7.2e-07 Score=93.23 Aligned_cols=215 Identities=11% Similarity=0.034 Sum_probs=119.6 Template_Neff=11.000 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC-SRDTYALEQSLTF 119 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~-~~~~~a~~~~~~~ 119 (908) ...++++||++.|..+. .++..+..+++.++++.+ + ++.+.+.. .+. +...+. T Consensus 50 ~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~l~~~~~~~~~~----~~~~~~ 103 (371) T 4WZZ_A 50 GYATTATYAIIVKSAGN------------PYNQKESEGYKQVIEANG--------G--KCVIQEPKSATA----EDQITC 103 (371) T ss_dssp -CCCCCEEEEECSCSSC------------HHHHHHHHHHHHHHHHTT--------C--EEEEECCSSSSH----HHHHHH T ss_pred CCCCCcEEEEEEcCCCC------------HHHHHHHHHHHHHHHHcC--------C--EEEEECCCCCCH----HHHHHH Confidence 35678999999987542 255677788888887752 3 33344433 232 233344 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGA-AASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~-~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. +++|++|+. ..+.........+...++|+|..+...+. ..++.+....+ T Consensus 104 ~~~li~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~v~~~~ 159 (371) T 4WZZ_A 104 INNAIS-------------------QGVDCIAIAANDTDALEPALTEAKNQGIHVLSLDSATNA-----NSRKVFVNQAG 159 (371) T ss_dssp HHHHHH-------------------HTCSEEEECCSSSSTTHHHHHHHHHTTCEEEEESSCCCG-----GGCSCEEESSC T ss_pred HHHHHH-------------------cCCCEEEEcCCCHHhHHHHHHHHHHCCCEEEEECCCCCc-----cccceEEeccC Confidence 444432 478888764 33333334455667789999987764432 12233444334 Q NP_000836.2 199 DSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREI--GGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~--~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ....++.+++++.+. +.++++++.. ++.+...+.++|++.+++. .++++....... .+..+....++++++. T Consensus 160 ~~~~~~~~~~~l~~~~~g~~~v~~l~~~~~~~~~~~r~~g~~~~~~~~~~~~~~v~~~~~~~--~~~~~~~~~~~~~l~~ 237 (371) T 4WZZ_A 160 TTQIAQALMDAILDISGGSGDWAVLSAASTATNQNAWIDGMKTVMQDSKYSKLNLIGVYYGD--DEYQASCDQTEAILAA 237 (371) T ss_dssp HHHHHHHHHHHHHHHTTSCEEEEEEESCTTCHHHHHHHHHHHHHTTSGGGTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHhCCCeeEEEEECCCCcHhHHHHHHHHHHHHhhccCCCcEEEEEecCC--CCHHHHHHHHHHHHHH Confidence 555677777777553 5678998873 3445667778888877642 124433221111 1122344455555431 Q NP_000836.2 273 -PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 -~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .+.++|+.. ++..+..+++++++.|+..++.+++. T Consensus 238 ~~~~~~i~~~-~~~~a~~~~~al~~~g~~~~v~v~~~ 273 (371) T 4WZZ_A 238 DPNIKVICAP-TTVGIMAAAKVLQDKGLSGKVKLTGL 273 (371) T ss_dssp CTTCCEEEEC-SHHHHHHHHHHHHHTTCTTTSEEEEB T ss_pred CCCCCEEEeC-CchHHHHHHHHHHHCCCCCCeEEEec Confidence 234555443 34456677888888776323444443 No 221 >1JX6_A LUXP PROTEIN; PROTEIN-LIGAND COMPLEX, SIGNALING PROTEIN; HET: AI2; 1.5A {Vibrio harveyi} SCOP: c.93.1.1 Probab=97.13 E-value=7.2e-07 Score=91.91 Aligned_cols=222 Identities=11% Similarity=0.029 Sum_probs=124.3 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+.. .+......+++.++++.+. .+.+++.+.|+..++. ...+.++ T Consensus 40 ~~~~~~Igvv~~~~~~~-----------~~~~~~~~g~~~~~~~~g~------~~~~~~~~~d~~~~~~----~~~~~~~ 98 (342) T 1JX6_A 40 TQRPIKISVVYPGQQVS-----------DYWVRNIASFEKRLYKLNI------NYQLNQVFTRPNADIK----QQSLSLM 98 (342) T ss_dssp CSSCEEEEEEECCCSSC-----------CHHHHHHHHHHHHHHHTTC------CEEEEEEECCTTCCHH----HHHHHHH T ss_pred CCCCEEEEEEecCCCCC-----------HHHHHHHHHHHHHHHHcCC------eEEEEEEecCCCCCHH----HHHHHHH Confidence 56789999999975321 1334778888888887642 1223334556544422 2333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|+...+.........+.. .++|+|..+...+.... ...++++++.+++. T Consensus 99 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d~~ 158 (342) T 1JX6_A 99 EALK-------------------SKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREW-DKHQPFLYVGFDHA 158 (342) T ss_dssp HHHH-------------------TTCSEEEECCSSSTTHHHHHHHHHHCSCEEEEETCCSCBGGG-TTSCCSEEEECCHH T ss_pred HHHh-------------------cCCCEEEEeCCchHHHHHHHHHHHhCCCeEEEEeCCCCcchh-cCCCCeEEEEcChH Confidence 4432 478888876533332333444443 78999987654432111 01356777888887 Q NP_000836.2 201 YQAQAMVDIVTALGWN--YVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~--~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~ 276 (908) ..+..+++++.+.+.+ +++++... +.++..+.+++++.+++.+++++....... .+..+....+++++.. .+++ T Consensus 159 ~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~~ 236 (342) T 1JX6_A 159 EGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTK--ATKQSGYDAAKASLAKHPDVD 236 (342) T ss_dssp HHHHHHHHHHHHHSCTTCEEEEECCSTTHHCCCCCCHHHHHHHHHHCCEEEEEECCC--SSHHHHHHHHHHHHHHCCCCS T ss_pred HHHHHHHHHHHHhcCCCCeEEEEEecCCcchHHHHHHHHHHHHhcCCceEEeeeccC--CCHHHHHHHHHHHHHHCCCCC Confidence 7888888887654443 48888754 445667777888877653223332211111 1122344455555421 2455 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +|+.. ++..+..+++++++.|. .++.+++. T Consensus 237 ~i~~~-~~~~a~~~~~~~~~~g~-~~~~v~~~ 266 (342) T 1JX6_A 237 FIYAC-STDVALGAVDALAELGR-EDIMINGW 266 (342) T ss_dssp EEEES-SHHHHHHHHHHHHHHTC-TTSEEBCS T ss_pred EEEEC-CHHHHHHHHHHHHHcCC-CCcEEEee Confidence 55554 34455667888887776 23344443 No 222 >4WT7_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; Enzyme Function Initiative, EFI, Structural; HET: X9X; 2.0A {Agrobacterium vitis S4} Probab=97.12 E-value=7.7e-07 Score=90.79 Aligned_cols=202 Identities=10% Similarity=-0.005 Sum_probs=116.3 Template_Neff=11.400 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..++++||++.|.++. .+......+++.++++. .+++.+.|+..++. ...+.++ T Consensus 29 ~~~~~~Ig~v~~~~~~------------~~~~~~~~~~~~a~~~~----------~~~l~~~~~~~~~~----~~~~~~~ 82 (321) T 4WT7_A 29 SLKGKRIGISTAGTDH------------FFDLQAYNAQIAEVKRL----------GGEPLAVDAGRSDG----KLVAQLQ 82 (321) T ss_dssp CCTTCEEEEEESCCSS------------HHHHHHHHHHHHHHHHT----------TCEEEEEECTTCHH----HHHHHHH T ss_pred hcCCcEEEEEcCCCCc------------HHHHHHHHHHHHHHHHc----------CCeEEEEeCCCCHH----HHHHHHH Confidence 4478999999997532 12334556666666543 24455556544322 2333444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. ++++++|... .+.........+.+.++|+|..+...+ ++++++.+++. T Consensus 83 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~ 135 (321) T 4WT7_A 83 TLIA-------------------QKPDAIVQLLGTLTVIDPWLKRARDAGIPVLTIDVGSS--------HSLNNSTSDNW 135 (321) T ss_dssp HHHH-------------------HCCSEEEEECCCHHHHHHHHHHHHHTTCCEEEESCCCT--------TCSCEEECCHH T ss_pred HHHH-------------------CCCCEEEEcCCChhhhHHHHHHHHHcCCCEEEECCCCC--------CcceeecCChH Confidence 4332 4677766543 333333445566778999998765432 34667777777 Q NP_000836.2 201 YQAQAMVDIVTA--LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQ--KIPREPRPGEFEKIIKRLLETPN 274 (908) Q Consensus 201 ~~~~~~~~~l~~--~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~~~~~~~~~~~~~~~l~~~~~ 274 (908) ..++.+++++.+ .+.++++++.. +..++..+.++|++.+++.+++++.... ... ..+..+....++++++ .+ T Consensus 136 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~-~~ 213 (321) T 4WT7_A 136 GIGKDLALQLVSDIGGEGNVVVFNGFYGVTPCAIRYDQLVNVIKYFPKVKIIQPELRDVI-PNTVQDAFAQVTAILN-KY 213 (321) T ss_dssp HHHHHHHHHHHHHTTTCEEEEEECCCTTSHHHHHHHHHHHHHHTTSTTEEECSSCBCCCS-SSHHHHHHHHHHHHHH-HS T ss_pred HHHHHHHHHHHHHhCCCceEEEEEcCCCCCcHHHHHHHHHHHHHHCCCcEEEcccccCCC-CCCHHHHHHHHHHHHH-HC Confidence 777777777755 47788999985 4456667788888877653213332210 010 0112234445555553 23 Q NP_000836.2 275 -----ARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 275 -----~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +++|++.. +..+..+++++++.|. T Consensus 214 ~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~ 242 (321) T 4WT7_A 214 PEKGSIKAIWSAW-DIPQLGATQALAAAGR 242 (321) T ss_dssp CSTTSCCEEEESS-HHHHHHHHHHHHHHTC T ss_pred CCcCCccEEEeCC-ChhHHHHHHHHHHCCC Confidence 56666553 4556678888887776 No 223 >2RJO_A Twin-arginine translocation pathway signal protein; PSI-2, NYSGXRC, twin arginine translocation; HET: SO4, GAL; 2.05A {Burkholderia phytofirmans} Probab=97.09 E-value=8.7e-07 Score=90.86 Aligned_cols=217 Identities=10% Similarity=0.034 Sum_probs=119.1 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|..+. .++..+..+++.++++.| +++.+.|+..++. ...+.+++ T Consensus 3 ~~~~~Igvv~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~ 56 (332) T 2RJO_A 3 LGQTTLACSFRSLTN------------PYYTAFNKGAQSFAKSVG----------LPYVPLTTEGSSE----KGIADIRA 56 (332) T ss_dssp CCCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CCEEEEECTTCHH----HHHHHHHH T ss_pred CCccEEEEEEcCCCC------------HHHHHHHHHHHHHHHHcC----------CCEEEeeCCCCHH----HHHHHHHH Confidence 467899999997542 255677788888887753 3344455443322 22333443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIG---AAASSVSIMVANILRLFKIPQISYASTAPELSDN-TRYDFFSRVVPP 198 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg---~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~-~~~~~~~~~~~~ 198 (908) ++. +++++++. +..+.........+...++|+|..+...+..... ...++++++..+ T Consensus 57 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~~~~~~~~~~v~~d 117 (332) T 2RJO_A 57 LLQ-------------------KTGGNLVLNVDPNDSADARVIVEACSKAGAYVTTIWNKPKDLHPWDYNPNYVAHLSYD 117 (332) T ss_dssp HHH-------------------HTTTCEEEEECCSSHHHHHHHHHHHHHHTCEEEEESCCCTTCCGGGGTTTEEEEEECC T ss_pred HHh-------------------cCCCEEEEEcCCCCcchHHHHHHHHHHcCCEEEEEcCCCCCCCcccCCCCceEEEecC Confidence 332 34565553 3222222334455667899999876544321100 012456677777 Q NP_000836.2 199 DSYQAQAMVDIVT-ALGWN-YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-- 272 (908) Q Consensus 199 ~~~~~~~~~~~l~-~~~~~-~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-- 272 (908) +...+..+++++. +.+.+ +++++.. +...+..+.++|++.+++..++.+....... .+..+....++++++. T Consensus 118 ~~~~~~~~~~~l~~~~g~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 195 (332) T 2RJO_A 118 GVAYGEETATQLFKSMGGKGGVVALGGIFSNVPAIERKAGLDAALKKFPGIQLLDFQVAD--WNSQKAFPIMQAWMTRFN 195 (332) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEEECCTTCHHHHHHHHHHHHHHHTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHHG T ss_pred hHHHHHHHHHHHHHHcCCCeEEEEEeCCCCCHHHHHHHHHHHHHHHhCCCcEEeeeEeCC--CCHHHHHHHHHHHHHHcc Confidence 7666777777764 45665 8998853 3345666777888877653124443211111 1112233445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++.. +..+..+++++++.|+..++.+++ T Consensus 196 ~~~d~i~~~~-~~~a~~~~~a~~~~g~~~~~~i~~ 229 (332) T 2RJO_A 196 SKIKGVWAAN-DDMALGAIEALRAEGLAGQIPVTG 229 (332) T ss_dssp GGEEEEEESS-HHHHHHHHHHHHHTTCBTTBCEEC T ss_pred CccCEEEECC-HHHHHHHHHHHHHCCCCCCCCEEc Confidence 2567776654 445567778888777632333333 No 224 >4Y9T_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE, PA1; 1.801A {Agrobacterium vitis} Probab=97.09 E-value=8.9e-07 Score=91.44 Aligned_cols=205 Identities=12% Similarity=0.072 Sum_probs=115.5 Template_Neff=11.000 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.| +++.+.|...+.. ...+.++ T Consensus 24 ~~~~~~Igvi~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~~~~ 77 (346) T 4Y9T_A 24 AQTKGMVYYLVPTLLD------------EFQTGSVNALSMFLGQVG----------YEMKTLNADNKTD----AQQSQMN 77 (346) T ss_dssp --CCCEEEEEESCCCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHH T ss_pred cCCCCEEEEEccCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCHH----HHHHHHH Confidence 3478999999987642 255677788888777653 3444555443322 2333344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. +++|++|+...+. ........+...++|+|..+...+. .++.+++.++.. T Consensus 78 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 132 (346) T 4Y9T_A 78 DVIA-------------------LKPAAIILAAVDFNALKPSIEAARAAGIPVVEFDRQITS------TPSDFTSVAGTV 132 (346) T ss_dssp HHHH-------------------HCCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCS------SCCSEEEEECHH T ss_pred HHHh-------------------cCCCEEEEcCCCccchHHHHHHHHHCCCCEEEeCCCCCC------CCCceEEEeChH Confidence 4332 4678777644332 2224445566789999987764331 134556666666 Q NP_000836.2 201 YQAQAMVDIVTALGW-------NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 201 ~~~~~~~~~l~~~~~-------~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) ..++.+++++.+.+. ++++++.. +..++..+.++|++.+++..++.+....... .+..+....++++++ T Consensus 133 ~~~~~~~~~l~~~~~~~~~~~~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~ 210 (346) T 4Y9T_A 133 EIGHIAGDHAISLLKGKNGDVKGKILQVPGDPGDPYTLDIQKGFEEKIKAFPGVKIISVPAVQ--WEASAAGTIVSDQML 210 (346) T ss_dssp HHHHHHHHHHHHHHBCTTSCBCEEEEEECCCTTCHHHHHHHHHHHHHHHTCTTEEEEECCCGG--GCHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHhcCCCCCceEEEEEecCCCCHHHHHHHHHHHHHHHhCCCcEEEEecCCC--CCHHHHHHHHHHHHH Confidence 667777777754333 78888875 3445667778888877653124433221111 111234445555542 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) . .++++|+.. .+..+..+++++++.|+. T Consensus 211 ~~~~~~~i~~~-~~~~a~~~~~al~~~g~~ 239 (346) T 4Y9T_A 211 ANPDIDLIFLH-AAHLSVAAVASLEAAGKK 239 (346) T ss_dssp HCTTCCEEEES-SHHHHHHHHHHHHHTTCC T ss_pred HCCCCCEEEEC-ChHHHHHHHHHHHHcCCC Confidence 1 245555544 344556677888877763 No 225 >4RU1_A Monosaccharide ABC transporter substrate-binding protein; SUGAR TRANSPORTER, ABC-TYPE, ENZYME FUNCTION; HET: INS, CIT; 1.5A {Acidothermus cellulolyticus} Probab=97.08 E-value=9.1e-07 Score=89.26 Aligned_cols=206 Identities=13% Similarity=0.059 Sum_probs=120.0 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....++++||++.|.++.. .....+..+++.++++.+ +++.+. + ..++ +...+ T Consensus 14 ~~~~~~~~~Ig~~~~~~~~~-----------~~~~~~~~~~~~~~~~~g--------~~~~~~--~-~~~~----~~~~~ 67 (304) T 4RU1_A 14 GKANTPHLTIAMITHQQPGD-----------TFWDIIRKGALAAAAKDN--------VTLKYS--N-DPDS----TKEAV 67 (304) T ss_dssp ---CCCCEEEEEEECCCTTC-----------THHHHHHHHHHHHHHHTT--------EEEEEE--E-CSSH----HHHHH T ss_pred cCCCCCCeEEEEEeCCCCCC-----------hHHHHHHHHHHHHHHHcC--------CEEEEe--C-CCCc----HHHHH Confidence 34567889999999974321 234567778888887753 333332 3 2222 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|+ +..+.........+...++|+|..+...+.. ...++++++.+ T Consensus 68 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~---~~~~~~~~v~~ 125 (304) T 4RU1_A 68 LIQDAVN-------------------AKVDGIAVTIPDPPALIPAIKQAVAAGIPVVAFNAGIDQW---KESGALMYFGQ 125 (304) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSHHHHHHHHHHHHHTTCCEEEESSCTTTH---HHHTCSEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCChHhhHHHHHHHHHCCCCEEEEeCCCccc---cccCCceEEec Confidence 3444432 47888887 4333333344456677899999877644321 11345677778 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLA--SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PN 274 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~--~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~ 274 (908) ++...+..+++++.+.+.++++++. .++.++..+.+++++.+++. +..+... . .+..+....++++++. .+ T Consensus 126 d~~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~---~--~~~~~~~~~~~~~l~~~~~ 199 (304) T 4RU1_A 126 DETVAGQAAGARATSEGFKHVLCVLQAQGQVQLESRCNGVQQTFKGQ-YTKLYVN---G--ADQPSVRTTIAAKLKQDPS 199 (304) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEEESSSSCHHHHHHHHHHHHHCCSE-EEEEECC---T--TCHHHHHHHHHHHHHHCTT T ss_pred CHHHHHHHHHHHHHHcCCceEEEEEcCCCcHHHHHHHHHHHHHHhcC-cceEEEc---C--CChHHHHHHHHHHHhhCCC Confidence 8777788888888777888999994 33445667777888877764 2333211 1 1112334445555431 23 Q NP_000836.2 275 ARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 275 ~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +++|++. ++..+..+++++++.|+ T Consensus 200 ~~~i~~~-~~~~~~~~~~~~~~~g~ 223 (304) T 4RU1_A 200 IDLVITL-GAPIAQLAIQAVKDAGS 223 (304) T ss_dssp CCEEEES-SHHHHHHHHHHHHHTTC T ss_pred CCEEEEC-ChhHHHHHHHHHHHcCC Confidence 6777644 34456677888887776 No 226 >4YV7_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE; 2.3A {Mycobacterium smegmatis} Probab=97.08 E-value=9.4e-07 Score=90.21 Aligned_cols=215 Identities=13% Similarity=0.046 Sum_probs=114.6 Template_Neff=11.900 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++.++||++.|..+. ..+.....+++.++++.+ +++.+.|+..++. ...+ T Consensus 34 ~~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~~----~~~~ 87 (326) T 4YV7_A 34 APVVDGALKIGFSQATQQS------------PFYVALTDAAKAEAQAQG----------DELFYADANGDIT----KQNN 87 (326) T ss_dssp -----CCCEEEEEESCCSS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHH T ss_pred CCccCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHcC----------CEEEEEcCCCCHH----HHHH Confidence 3456778999999997542 245667788888887753 3444555543322 2233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++++...+... ......+...++|+|..+...+ .++.+.+.+ T Consensus 88 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~~ 141 (326) T 4YV7_A 88 DVQDLIT-------------------RGINVLVINPVDPKGVTPSLAAAEAAGIKVVTVDRPVE-------SGAASFVGR 141 (326) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCS-------SCCSEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCCccccHHHHHHHHHCCCeEEEeCCCCC-------CCcceEEec Confidence 3443332 478877765443322 2344556678999998765432 134556666 Q NP_000836.2 198 PDSYQAQAMVDIVT----ALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 198 ~~~~~~~~~~~~l~----~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ++...++.+++++. +.+.+.+.++.. ++.++..+.+++++.+++.+++.+....... .+..+....++++++ T Consensus 142 d~~~~~~~~~~~~~~~l~~~g~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~ 219 (326) T 4YV7_A 142 DNKAMGELVGKAAVDTLGPDGGKIIEIQGDAGGAVARDRRDGFQAAVSGRPNITIVEGPYCD--YIRSKAVTAMQDLLQA 219 (326) T ss_dssp CHHHHHHHHHHHHHHHHGGGCEEEEEEECCTTCHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHCCCCcEEEEEEcCCCCHHHHHHHHHHHHHHhcCCCeEEeeccccc--CcHHHHHHHHHHHHHH Confidence 66655655444432 234444444432 3456667778888877664124433211111 111223344555542 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ..++|+|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 220 ~~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~~~i~~~~ 255 (326) T 4YV7_A 220 HPDLKGVYAQN-DDMALGAMQVLAENNRT-DVKVFGVD 255 (326) T ss_dssp CTTEEEEEESS-HHHHHHHHHHHHHTTCT-TSEEECSB T ss_pred CCCCcEEEeCC-hHHHHHHHHHHHHCCCC-CcEEEEec Confidence 13677776654 44456677888877762 34444443 No 227 >2FN9_B ribose ABC transporter, periplasmic ribose-binding; RBP, ribose binding protein, periplasmic; 1.4A {Thermotoga maritima} Probab=97.06 E-value=1e-06 Score=88.25 Aligned_cols=202 Identities=10% Similarity=0.046 Sum_probs=110.6 Template_Neff=11.700 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.| +++.+.++..+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~~~~ 55 (290) T 2FN9_B 2 KGKMAIVISTLNN------------PWFVVLAETAKQRAEQLG----------YEATIFDSQNDT----AKESAHFDAII 55 (290) T ss_dssp -CEEEEEESCSSS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHHHHH T ss_pred CceEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCH----HHHHHHHHHHH Confidence 5689999987542 255677788888887653 233444443332 12233334333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....+... ......+...++|+|..+...+. ..++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~~ 111 (290) T 2FN9_B 56 A-------------------AGYDAIIFNPTDADGSIANVKRAKEAGIPVFCVDRGINA-----RGLAVAQIYSDNYYGG 111 (290) T ss_dssp H-------------------HTCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCSC-----SSSSSEEEEECHHHHH T ss_pred H-------------------cCCCEEEEcCCCCcccHHHHHHHHHCCCCEEEECCCCCC-----CCCceEEEEeCchHHH Confidence 2 477877765433322 13344566789999987764431 1234566677776677 Q NP_000836.2 204 QAMVDIVTALG------WNYVSTLA----SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-T 272 (908) Q Consensus 204 ~~~~~~l~~~~------~~~v~ii~----~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~ 272 (908) +.+++++.+.+ .++++++. .+..+...+.+++++.+++.+...+....... .+..+....+++++. . T Consensus 112 ~~~~~~l~~~~~~~~~~~~~i~~i~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~ 189 (290) T 2FN9_B 112 VLAGEYFVKFLKEKYPDAKEIPYAELLGILSAQPTWDRSNGFHSVVDQYPEFKMVAQQSAE--FDRDTAYKVTEQILQAH 189 (290) T ss_dssp HHHHHHHHHHHHHHSTTCSCEEEEEEECCTTCHHHHHHHHHHHHHHTTSTTEEEEEEEECT--TCHHHHHHHHHHHHHHC T ss_pred HHHHHHHHHHHHHHCCCccccCEEEEEeeCCCchHHHHHHHHHHHHHhCCCcEEeeeecCC--CCHHHHHHHHHHHHHHC Confidence 77777765433 26777633 23344556777777777654212222111111 111223344455542 1 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) .++|+|++. ++..+..+++++++.|+ T Consensus 190 ~~~d~i~~~-~~~~a~~~~~~l~~~g~ 215 (290) T 2FN9_B 190 PEIKAIWCG-NDAMALGAMKACEAAGR 215 (290) T ss_dssp TTCCEEEES-SHHHHHHHHHHHHHHTC T ss_pred CCCCEEEEC-ChHHHHHHHHHHHHcCC Confidence 367888766 35556778888877776 No 228 >4XXH_B PROTEIN (TREHALOSE OPERON REPRESSOR); LACI FAMILY, PHOSPHATE BINDING, PROTEIN; HET: T6P; 2.4A {Escherichia coli K-12} Probab=97.06 E-value=1e-06 Score=86.09 Aligned_cols=192 Identities=11% Similarity=0.087 Sum_probs=114.8 Template_Neff=12.100 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ + ++.+.++..++. ...+.++++. T Consensus 2 ~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~~~~~~ 55 (255) T 4XXH_B 2 DKVVAIIVTRLDS------------LSENLAVQTMLPAFYEQG--------Y--DPIMMESQFSPQ----LVAEHLGVLK 55 (255) T ss_dssp CCEEEEEESCTTC------------HHHHHHHHHHHHHHHHHT--------C--EEEEEECTTCHH----HHHHHHHHHH T ss_pred CeEEEEEECCCCC------------hhHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999987542 255667778887777642 2 334444433321 2223333333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 204 (908) . .++|++|+...+... ...+...++|+|..+... +.++++.+++...++ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~---~~~~~~~~ip~v~~~~~~---------~~~~~v~~~~~~~~~ 104 (255) T 4XXH_B 56 R-------------------RNIDGVVLFGFTGIT---EEMLAHWQSSLVLLARDA---------KGFASVCYDDEGAIK 104 (255) T ss_dssp H-------------------TTCSEEEEECCTTCC---TGGGGGGTTSEEEESSCC---------TTSEEEEECHHHHHH T ss_pred h-------------------CCCCEEEEecCCCCc---HHHHHhcCCeEEEECCCC---------CCCCEEEeCHHHHHH Confidence 2 478888875544332 234566799988765422 245667777777788 Q NP_000836.2 205 AMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMF 281 (908) Q Consensus 205 ~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~ 281 (908) .+++++.+.+.++++++..+.. ++..+.+++++.+++. ++.+... ... .+..+....+++++. .++|+|++. T Consensus 105 ~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~~~-~~~dai~~~ 179 (255) T 4XXH_B 105 ILMQRLYDQGHRNISYLGVPHSDVTTGKRRHEAYLAFCKAH-KLHPVAA-LPG--LAMKQGYENVAKVIT-PETTALLCA 179 (255) T ss_dssp HHHHHHHHTTCCCEEEECCCTTSCCCCCCHHHHHHHHHHHT-TCCCCEE-CCC--SCHHHHHHHGGGGCC-TTCCEEEES T ss_pred HHHHHHHHCCCCcEEEEeCChhccccHHHHHHHHHHHHHHC-CCCCcee-cCC--CcchhHHHHHHHHhC-CCCCEEEEe Confidence 8888887678889999985433 4667778888887764 3433211 111 111123334555553 578888776 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~ 299 (908) . +..+..+++++++.|+ T Consensus 180 ~-~~~a~~~~~~~~~~g~ 196 (255) T 4XXH_B 180 T-DTLALGASKYLQEQRI 196 (255) T ss_dssp S-HHHHHHHHHHHHHTTC T ss_pred c-HHHHHHHHHHHHHCCC Confidence 4 4456677888877776 No 229 >5IX8_B Putative sugar ABC transport system; Structural Genomics, Midwest Center for; HET: EDO, SO4, MSE; 1.6A {Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)} Probab=97.04 E-value=1.1e-06 Score=89.41 Aligned_cols=208 Identities=14% Similarity=0.032 Sum_probs=120.9 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVR-ILDTCSRDTYALEQSLT 118 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~-~~d~~~~~~~a~~~~~~ 118 (908) ....+.++||++.|..+. .++.....+++.++++.+ +++.+. ..|+..+. ....+ T Consensus 10 ~~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~~----~~~~~ 65 (321) T 5IX8_B 10 IVARQPLKLGVTVVHLLD------------NFYKGIAYGIVDEARRSN--------VEVVQVAVAGAYGNV----QQQFA 65 (321) T ss_dssp CCCCSCCEEEEEESCSSS------------SHHHHHHHHHHHHHHHHT--------CEEEEEEECSSTTCH----HHHHH T ss_pred cccCCCcEEEEEECCCCC------------HHHHHHHHHHHHHHHHCC--------CEEEEEEecCCCCCH----HHHHH Confidence 345678999999987542 255677888888888763 445543 23332332 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. .+++++|..... .........+.+.++|+|..+...+. .++.+++.+ T Consensus 66 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~ 120 (321) T 5IX8_B 66 QLQSFKT-------------------LGVDYAVLSPAAYSGYDPVVADLARSGIKTISAGIPVNS------DKIAFGVLQ 120 (321) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSSSSCHHHHHHHHHTTCEEEEESSCCSC------TTCCEEEEC T ss_pred HHHHHHH-------------------cCCCEEEEcCCCccccHHHHHHHHHCCCEEEEECCCCCC------CcceEEEEc Confidence 3444332 467776654332 22234445666789999987654321 245667777 Q NP_000836.2 198 PDSYQAQAMVDIVTALGW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET- 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~- 272 (908) ++...+..+++++.+.+. ++++++.. ++.++..+.+++++.+++. ++.+.... .....+..+....++++++. T Consensus 121 d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-g~~~~~~~-~~~~~~~~~~~~~~~~~~~~~ 198 (321) T 5IX8_B 121 DDTLIGKVLGKALCDDGAQGKQVIVVPGAAGLEWPRLRYEGFKEVASAC-GAKLTPAA-FRGEMSLADGMAQTQDLLMRT 198 (321) T ss_dssp CHHHHHHHHHHHHHHTTCTTCEEEECCCCSSSSHHHHHHHHHHHHHHHT-TCEECCCC-CCSCCCHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHccCCCcEEEEEeCCCCCcHHHHHHHHHHHHHHhc-CCEEEeee-ecCCCCHHHHHHHHHHHHHhC Confidence 777778888888765554 48888875 4456677888888888765 34443211 11001122344445555421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) .++++|+... +..+..+++++++.|+ T Consensus 199 ~~~~~i~~~~-~~~a~~~~~~~~~~g~ 224 (321) T 5IX8_B 199 PDAEYVFTPV-TFLGIGAVRAARQANR 224 (321) T ss_dssp TTEEEEECSS-HHHHHHHHHHHHHTTC T ss_pred CCCCEEEeCC-hHHHHHHHHHHHHcCC Confidence 2355565543 4455667888887776 No 230 >4WUT_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: FCB, MSE; 1.5A {Agrobacterium vitis} Probab=97.04 E-value=1.1e-06 Score=89.04 Aligned_cols=222 Identities=9% Similarity=0.031 Sum_probs=119.1 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) ....++..+||++.|..+. .+...+..+++.++++.+. ..+.+...|...++ +...+ T Consensus 17 ~l~~~~~~~I~vi~~~~~~------------~~~~~~~~~~~~~~~~~g~-------~~~~~~~~~~~~~~----~~~~~ 73 (313) T 4WUT_A 17 NLYFQSMGEIAVIVKTVNS------------TFWQNVQKGADAAIGKQKA-------HTITFQGPAAESAI----ADQVN 73 (313) T ss_dssp -------CEEEEECSCSSC------------HHHHHHHHHHHHHHTTCSS-------CEEEEECCSSTTCH----HHHHH T ss_pred cccccCCcEEEEEECCCCC------------HHHHHHHHHHHHHHHhcCc-------eEEEEeCCcccccH----HHHHH Confidence 3456678999999987542 2456777888888877542 11223222222221 12233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. +++|++|........ ......+...++|+|..+...+.. ....+++.+.+ T Consensus 74 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~ 131 (313) T 4WUT_A 74 MVENAVN-------------------RKVDAILLAPSDPDALVPAVKKAWEARIPVVIIDSMLSKD---AEKYYQAFLAT 131 (313) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCGG---GGGGCSEEEEC T ss_pred HHHHHHh-------------------CCCCEEEECCCCHHhhHHHHHHHHHCCCCEEEEeCCCCcc---hhhheEEEEEC Confidence 3443332 478877764433222 233445667899999887644321 01134567777 Q NP_000836.2 198 PDSYQAQAMVDIVTALGW--NYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-T 272 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~--~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~ 272 (908) ++...++.+++++.+.+. ++++++.. +...+..+.+++++.+++.+...+....... .+..+....+++++. . T Consensus 132 d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~ 209 (313) T 4WUT_A 132 DNKAAGELAAKAMIQKVGTEGKIAVMSYVAGAGSEIGRVGGFTDYIKANSKLQIVGPYYSQ--SQMATALNQTTDVLAAN 209 (313) T ss_dssp CHHHHHHHHHHHHHHHHCSSSEEEEEESSTTCHHHHHHHHHHHHHHHHHCCCEEEEEEECT--TCHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHHHCCCeEEEEEEccCCChhHHHHHHHHHHHHHHcCCcEEEeccCCc--ccHHHHHHHHHHHHHHC Confidence 777778888888866555 78998875 3345556778888887765312332211111 111223333444432 1 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++.. +..+..+++++++.|...++.+++. T Consensus 210 ~~~~~i~~~~-~~~a~~~~~al~~~g~~~~i~i~~~ 244 (313) T 4WUT_A 210 ADLKGIFGAN-EPTAIGMGRAIKQAGKAGKLVAIGF 244 (313) T ss_dssp TTCCEEEECS-HHHHHHHHHHHHHTTCTTSSEEEEE T ss_pred CCCCEEEEcC-hhHHHHHHHHHHHcCCCCCEEEEEe Confidence 3567777664 4455677888887776323444443 No 231 >3HCW_A Maltose operon transcriptional repressor; RNA-BINDING, TRANSCRIPTIONAL REPRESSOR, PSI-2, NYSGXRC; HET: GOL; 2.2A {Staphylococcus aureus subsp. aureus Mu50} Probab=97.03 E-value=1.2e-06 Score=87.99 Aligned_cols=207 Identities=11% Similarity=0.084 Sum_probs=118.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|.++.... ...+......+++.++++. |+ ++.+.+...+. +...+.++ T Consensus 4 ~~~~~~I~~v~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~--------g~--~~~~~~~~~~~----~~~~~~~~ 62 (295) T 3HCW_A 4 TNQTYKIGLVLKGSEEPIR-------LNPFYINVLLGISETCNQH--------GY--GTQTTVSNNMN----DLMDEVYK 62 (295) T ss_dssp CCCSCEEEEECSCCCHHHH-------SCHHHHHHHHHHHHHHHTT--------TC--EEEECCCCSHH----HHHHHHHH T ss_pred cCCccEEEEEecCCCCccc-------cChHHHHHHHHHHHHHHHh--------CC--EEEEEecCCCc----hhHHHHHH Confidence 4578899999987431000 0124556677777776653 23 33344433321 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .++. .++|++|+...+.. ..+...+...++|+|..+...+. ..+.++.+.+++.. T Consensus 63 ~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~ 117 (295) T 3HCW_A 63 MIKQ-------------------RMVDAFILLYSKEN-DPIKQMLIDESMPFIVIGKPTSD-----IDHQFTHIDNDNIL 117 (295) T ss_dssp HHHT-------------------TCCSEEEESCCCTT-CHHHHHHHHTTCCEEEESCCCSS-----GGGGSCEEEECHHH T ss_pred HHHH-------------------cCCCEEEEeCCCCC-CHHHHHHHHCCCCEEEECCCCCc-----ccccCCEEecChHH Confidence 3332 47888887544433 34455667789999988754321 12345667777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL----ETPNA 275 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~----~~~~~ 275 (908) .++.+++++.+.+.++++++..+. ..+..+.++|++.+++. ++.+... ... .+..+....+++++ ...++ T Consensus 118 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~l~~~-~~~~~~~-~~~--~~~~~~~~~~~~~~~~~~~~~~~ 193 (295) T 3HCW_A 118 ASENLTRHVIEQGVDELIFITEKGNFEVSKDRIQGFETVASQF-NLDYQII-ETS--NEREVILNYMQNLHTRLKDPNIK 193 (295) T ss_dssp HHHHHHHHHHHHCCSEEEEEEESSCCHHHHHHHHHHHHHHHHT-TCEEEEE-EEC--SCHHHHHHHHHHHHHHHTCTTSC T ss_pred HHHHHHHHHHHcCCCEEEEEeCCCCChhHHHHHHHHHHHHHHC-CCCceEE-ecC--CCHHHHHHHHHHHHHHhcCCCCC Confidence 888888888767888999988543 25566778888888765 3443211 111 11122333344432 12346 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) |+|++.. +..+..+++++++.|+ T Consensus 194 d~i~~~~-~~~~~~~~~~l~~~g~ 216 (295) T 3HCW_A 194 QAIISLD-AMLHLAILSVLYELNI 216 (295) T ss_dssp EEEEESS-HHHHHHHHHHHHHTTC T ss_pred cEEEECC-HHHHHHHHHHHHHCCC Confidence 7777664 4456678888888776 No 232 >1JYE_A Lactose Operon Repressor; Gene Regulation, Protein Stability, Protein; 1.7A {Escherichia coli} SCOP: c.93.1.1 Probab=97.02 E-value=1.2e-06 Score=90.41 Aligned_cols=203 Identities=13% Similarity=0.080 Sum_probs=115.3 Template_Neff=11.300 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.++ T Consensus 58 ~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~ 112 (349) T 1JYE_A 58 GKQSLLIGVATSSLAL------------HAPSQIVAAILSRADQLG--------ASVVVSMVER-SGV----EACKTAVH 112 (349) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------CEEEEEECCS-SSH----HHHHHHHH T ss_pred cCCCcEEEEEeCCccC------------ccHHHHHHHHHHHHHHcC--------CEEEEEecCC-ChH----HHHHHHHH Confidence 4578899999987542 255677788888887653 3333322221 121 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.........+...++|+|..+...+ +.+..+..+... T Consensus 113 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 165 (349) T 1JYE_A 113 NLLA-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHED 165 (349) T ss_dssp HHHT-------------------TTCSCEEEESCCCHHHHHHHHHHTTTSCEEESSSCTT--------SSSCEEEECHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCcHHHHHHHHHhcCCCEEEEeCCCC--------CCCCEEEEccHH Confidence 4332 4788888764443322222345678999998765322 234455666666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.++++++++.. +..+...+.++|++.+++. ++.+....... .+..+....+++++. ..++++| T Consensus 166 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~~i 242 (349) T 1JYE_A 166 GTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAM 242 (349) T ss_dssp HHHHHHHHHHHHTCCSEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCcccHHHHHHHHHHHHHHHHC-CCCCceeeecC--CChhHHHHHHHHHHhcCCCCCEE Confidence 6777788876668899999985 3345667788888888775 35443211111 111223334455542 1347777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 243 ~~~~-d~~a~~~~~~l~~~g~~ 263 (349) T 1JYE_A 243 LVAN-DQMALGAMRAITESGLR 263 (349) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EEcC-HHHHHHHHHHHHHcCCC Confidence 6654 44566778888887764 No 233 >2PE5_B Lactose operon repressor/DNA Complex; Lac repressor, allosteric effectors, gene; HET: 145; 3.5A {Escherichia coli} SCOP: a.35.1.5, c.93.1.1 Probab=97.02 E-value=1.3e-06 Score=89.42 Aligned_cols=203 Identities=12% Similarity=0.060 Sum_probs=116.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+.++||++.|..+. .++..+..+++.++++.+ +++.+...+. .++ +...+.++ T Consensus 57 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~~ 111 (330) T 2PE5_B 57 GKQLLLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAVH 111 (330) T ss_dssp TCCCEEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------EEEEEEECCS-CSH----HHHHHHHH T ss_pred hCCCCEEEEEeCCCCC------------ccHHHHHHHHHHHHHHcC--------CEEEEEecCC-CcH----HHHHHHHH Confidence 3568899999987542 245677888888887753 3444433332 221 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.........+...++|+|..+...+ +.++.+..+... T Consensus 112 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~--------~~~~~v~~d~~~ 164 (330) T 2PE5_B 112 NLLA-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHED 164 (330) T ss_dssp HHHH-------------------TTCSEEEEESCCCHHHHHHHHHHSCSSCEEESSSCSS--------SSSCEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCcHHHHHHHHHhcCCCEEEEcCCCC--------CCCCEEEEccHH Confidence 3332 4788888754433322222234578999998765422 234455566666 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.++++++++.. ++.....+.++|++.+++. ++.+....... .+..+....+.+++. ..++++| T Consensus 165 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~~i 241 (330) T 2PE5_B 165 GTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTAM 241 (330) T ss_dssp HHHHHHHHHHHHTCCSEEEEECCTTSHHHHHHHHHHHHHHHTT-TCCCSCEEECC--SCHHHHHHHHHHHHHHTCCCSEE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCcccccHHHHHHHHHHHHHHC-CCCCceeeeCC--CchhHHHHHHHHHHhcCCCCCEE Confidence 6777778776668889999985 3345566778888888775 34433211111 111122333444442 1247777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|.. T Consensus 242 ~~~~-~~~a~~~~~~l~~~g~~ 262 (330) T 2PE5_B 242 LVAN-DQMALGAMRAITESGLR 262 (330) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EEcC-HHHHHHHHHHHHHCCCC Confidence 6664 44566778888877764 No 234 >3C3K_B Alanine racemase (E.C.5.1.1.1); STRUCTURAL GENOMICS, PROTEIN STRUCTURE INITIATIVE; HET: GOL; 1.99A {Actinobacillus succinogenes} Probab=97.01 E-value=1.3e-06 Score=87.08 Aligned_cols=203 Identities=14% Similarity=0.060 Sum_probs=115.2 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..+++.+||++.|.... .++.....+++.++++.+ + ++.+.+...+. ....+.+ T Consensus 4 ~~~~~~~I~~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 57 (285) T 3C3K_B 4 RTAKTGMLLVMVSNIAN------------PFCAAVVKGIEKTAEKNG--------Y--RILLCNTESDL----ARSRSCL 57 (285) T ss_dssp ---CCEEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT--------E--EEEEEECTTCH----HHHHHHT T ss_pred ccCCCceEEEEecCCCc------------HHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHH Confidence 34567899999984321 355677888888887753 2 33444443332 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. .++|++|+...+.....+ ..+.. ++|+|..+...+ .+..+.+.+++. T Consensus 58 ~~~~~-------------------~~~d~ii~~~~~~~~~~~-~~~~~-~ip~v~~~~~~~-------~~~~~~v~~d~~ 109 (285) T 3C3K_B 58 TLLSG-------------------KMVDGVITMDALSELPEL-QNIIG-AFPWVQCAEYDP-------LSTVSSVSIDDV 109 (285) T ss_dssp HHHHT-------------------TSCSCEEECSCGGGHHHH-HHHHT-TSCEEEESCCCT-------TCSSEEEECCHH T ss_pred HHHhc-------------------CCCCEEEEecCCCCcHHH-HHHHh-cCCEEEeCCCCC-------CCCCcEEEeCcH Confidence 33322 478888876544332222 22333 899888765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++..+ ......+.++|++.+++. ++.+....... ..+..+....+++++. ..++++ T Consensus 110 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~l~~~~~~~~ 187 (285) T 3C3K_B 110 AASEYVVDQLVKSGKKRIALINHDLAYQYAQHRESGYLNRLKFH-GLDYSRISYAE-NLDYMAGKLATFSLLKSAVKPDA 187 (285) T ss_dssp HHHHHHHHHHHHTTCCCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCCEEEECS-SSSHHHHHHHHHHHHSSSSCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEecCccchhHHHHHHHHHHHHHHC-CCCCCceeecC-CCchHHHHHHHHHHHhcCCCCCE Confidence 777788888766678899999853 334566778888887765 34433211110 0111223333444432 134777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 188 i~~~~-~~~a~~~~~al~~~g~~ 209 (285) T 3C3K_B 188 IFAIS-DVLAAGAIQALTESGLS 209 (285) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-hHHHHHHHHHHHHCCCC Confidence 76664 44567788888887764 No 235 >8ABP_A L-ARABINOSE-BINDING PROTEIN (MUTANT WITH MET; BINDING PROTEINS; HET: GAL, GLA; 1.49A {Escherichia coli} SCOP: c.93.1.1 Probab=97.01 E-value=1.3e-06 Score=88.08 Aligned_cols=214 Identities=12% Similarity=0.073 Sum_probs=115.1 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ +++.+.++ .++ +...+.+++++ T Consensus 2 ~~~Ig~~~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~-~~~----~~~~~~~~~l~ 54 (306) T 8ABP_A 2 NLKLGFLVKQPEE------------PWFQTEWKFADKAGKDLG----------FEVIKIAV-PDG----EKTLNAIDSLA 54 (306) T ss_dssp CEEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------EEEEEEEC-CSH----HHHHHHHHHHH T ss_pred CeEEEEEECCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeC-CCH----HHHHHHHHHHH Confidence 5789999987542 245667788888877652 33344444 232 22233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++|. +..+.........+...++|+|..+...+.... ...++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 114 (306) T 8ABP_A 55 A-------------------SGAKGFVICTPDPKLGSAIVAKARGYDMKVIAVDDQFVNAKG-KPMDTVPLVMLAATKIG 114 (306) T ss_dssp H-------------------TTCCEEEEECSCGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCTTSCEEEECHHHHH T ss_pred H-------------------cCCCEEEEeCCCcchhHHHHHHHHhCCCEEEEEccccccCCC-CCcccccEEeechhHHH Confidence 2 46786554 333332234445667789999988765432211 11345677777777777 Q NP_000836.2 204 QAMVDIVTA----LGWN--YVSTLASE---GNYGESGVEAFTQISREIG--GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 204 ~~~~~~l~~----~~~~--~v~ii~~~---~~~~~~~~~~~~~~~~~~~--~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +.+++++.+ .+++ +++++..+ ..++..+.++|++.+++.+ ..++....... .+..+....++++++ T Consensus 115 ~~~~~~l~~~~~~~g~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~- 191 (306) T 8ABP_A 115 ERQGQELYKEMQKRGWDVKESAVMAITANELDTARRRTTGSMDALKAAGFPEKQIYQVPTKS--NDIPGAFDAANSMLV- 191 (306) T ss_dssp HHHHHHHHHHHHHHTCCGGGEEEEEEECTTSHHHHHHHHHHHHHHHHHTCCGGGEEEEECSS--SSHHHHHHHHHHHHT- T ss_pred HHHHHHHHHHHHHcCCCcccceEEEEecCCChHHHHHHHHHHHHHHHcCCCcceeeeecCCC--CChhHHHHHHHHHHH- Confidence 777776643 3555 66666532 2455567778887777642 02222111111 111233444555543 Q NP_000836.2 273 PNARA---VIMFANEDDIRRILEAAKKLNQS-GHFLWIGS 308 (908) Q Consensus 273 ~~~~v---iv~~~~~~~~~~~l~~~~~~g~~-~~~~~i~~ 308 (908) .+++. ++++.++..+..+++++++.|+. .++.+++. T Consensus 192 ~~~~~~~~~i~~~~~~~a~~~~~~~~~~g~~~~~i~i~~~ 231 (306) T 8ABP_A 192 QHPEVKHWLIVGMNDSTVLGGVRATEGQGFKAADIIGIGI 231 (306) T ss_dssp TCTTCSEEEEECSSHHHHHHHHHHHHHTTCCGGGEEEEEE T ss_pred HCCCCceEEEEEcchhhHHHHHHHHHhCCCCHhcEEEEEe Confidence 23443 33444455567788888888764 13444443 No 236 >5ABP_A L-ARABINOSE-BINDING PROTEIN COMPLEX WITH D-GALACTOSE; BINDING PROTEIN; HET: GAL, GLA; 1.8A {Escherichia coli} SCOP: c.93.1.1 Probab=97.01 E-value=1.3e-06 Score=88.06 Aligned_cols=214 Identities=12% Similarity=0.076 Sum_probs=114.6 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++.....+++.++++.+ +++.+.+. .++ ....+.+++++ T Consensus 2 ~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~-~~~----~~~~~~~~~l~ 54 (306) T 5ABP_A 2 NLKLGFLVKQPEE------------PWFQTEWKFADKAGKDLG----------FEVIKIAV-PDG----EKTLNAIDSLA 54 (306) T ss_dssp CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEEC-CSH----HHHHHHHHHHH T ss_pred CcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEeC-CCH----HHHHHHHHHHH Confidence 5789999987542 255677788888877652 23333443 232 22233444443 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++| ++..+.........+...++|+|.++...+.... ...++++++.+++...+ T Consensus 55 ~-------------------~~~d~iii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 114 (306) T 5ABP_A 55 A-------------------SGAKGFVICTPDPKLGSAIVAKARGYDMKVIAVDDQFVNAKG-KPMDTVPLVMMAATKIG 114 (306) T ss_dssp H-------------------TTCCEEEEECSCGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCTTSCEEEECHHHHH T ss_pred H-------------------CCCCEEEEeCCCcchHHHHHHHHHhCCCEEEEEcCccccCCC-CCCccceEeeechhHHH Confidence 2 4677544 4444333334455667789999988765432111 01235677777776667 Q NP_000836.2 204 QAMVDIVTA----LGWN--YVSTLASE---GNYGESGVEAFTQISREIG--GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 204 ~~~~~~l~~----~~~~--~v~ii~~~---~~~~~~~~~~~~~~~~~~~--~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +.+++++.+ .+++ ++.++..+ ..++..+.+++++.+++.+ ..++....... .+..+....++++++ T Consensus 115 ~~~~~~l~~~~~~~g~~~~~i~v~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~--~~~~~~~~~~~~~l~- 191 (306) T 5ABP_A 115 ERQGQELYKEMQKRGWDVKESAVMAITANELDTARRRTTGSMDALKAAGFPEKQIYQVPTKS--NDIPGAFDAANSMLV- 191 (306) T ss_dssp HHHHHHHHHHHHHTTCCGGGEEEEEEECTTSHHHHHHHHHHHHHHHHTTCCGGGEEEEECSS--SSHHHHHHHHHHHHT- T ss_pred HHHHHHHHHHHHHcCCCccccEEEEEEcCCChHHHHHHHHHHHHHHHcCCCCceeEecCCCC--CChHHHHHHHHHHHH- Confidence 777766533 3555 76666532 2455667778888777642 02222111111 112234455566553 Q NP_000836.2 273 PNARA---VIMFANEDDIRRILEAAKKLNQS-GHFLWIGS 308 (908) Q Consensus 273 ~~~~v---iv~~~~~~~~~~~l~~~~~~g~~-~~~~~i~~ 308 (908) .+++. ++++.++..+..+++++++.|+. .++.+++. T Consensus 192 ~~~~~~~~~i~~~~~~~a~~~~~~~~~~g~~~~~i~v~~~ 231 (306) T 5ABP_A 192 QHPEVKHWLIVGMNDSTVLGGVRATEGQGFKAADIIGIGI 231 (306) T ss_dssp TCTTCCEEEEECSSHHHHHHHHHHHHHTTCCGGGEEEEEE T ss_pred HCCCCceEEEEEechHHHHHHHHHHHhCCCChhcEEEEEe Confidence 23443 23333444567788888887764 13344443 No 237 >4KVF_A Rhamnose ABC transporter, periplasmic rhamnose-binding; structural genomics, PSI-Biology, Protein Structure; HET: GOL; 1.722A {Kribbella flavida} Probab=96.99 E-value=1.5e-06 Score=89.53 Aligned_cols=217 Identities=11% Similarity=0.057 Sum_probs=118.1 Template_Neff=11.400 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|..+. .++.....+++.++++.| +++.+...+. .++ ....+ T Consensus 33 ~~~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~a~~~~~--------~~v~~~~~~~-~~~----~~~~~ 87 (342) T 4KVF_A 33 NAPLKEGLKIAYLPKQLNN------------PYTDVEVGGGKVAVGEIK--------GEYKLVGPND-ASA----SSQVS 87 (342) T ss_dssp TSCCCSSCEEEEECSSSSS------------HHHHHHHHHHHHHHHHTT--------CEEEECCCCT-TCC----CCHHH T ss_pred CCCccCCeEEEEEcCCCCC------------hHHHHHHHHHHHHHHHhC--------CEEEEECCCC-CCH----HHHHH Confidence 3455678999999986542 245667788888888764 2344443332 221 12233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIG-AAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg-~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .+++++. ++++++|+ +..+.........+...++|+|..+...+. ..++.+.... T Consensus 88 ~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~v~~~ 143 (342) T 4KVF_A 88 YINTLIQ-------------------QQQDVIVVAANDPNAVCPSLNQARKADIKVVTFDSDAAK-----TCRDAFINQA 143 (342) T ss_dssp HHHHHHH-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCEEEEESSCCCG-----GGCSEEEESS T ss_pred HHHHHHH-------------------cCCCEEEEcCCCHHhhHHHHHHHHHCCCEEEEECCCCcc-----cccceEeeCC Confidence 3444332 47888887 333333334445566789999987654331 1122233222 Q NP_000836.2 198 PDSYQAQAMVDIVTALG--WNYVSTLAS--EGNYGESGVEAFTQISREI--GGVCIAQSQKIPREPRPGEFEKIIKRLLE 271 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~--~~~v~ii~~--~~~~~~~~~~~~~~~~~~~--~~i~v~~~~~~~~~~~~~~~~~~~~~l~~ 271 (908) +....++.+++++.+.+ .++++++.. ++.+...+.++|++.+++. .++++....... .+..+....++++++ T Consensus 144 ~~~~~~~~~~~~l~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~ 221 (342) T 4KVF_A 144 TTQGIGESLVKMAKELAGGSGEIAVLSATPNATNQNSWIEVMKTELAKPENAKLKLVKIAYGN--DDDQKSFTEAQGLLQ 221 (342) T ss_dssp CHHHHHHHHHHHHHHHTTTCEEEEEEESCTTCHHHHHHHHHHHHHHTSGGGTTEEEEEEEECT--TCHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHhCCCcEEEEEECCCCchhHHHHHHHHHHHHcCcccCCcEEEEEeeCC--CCHHHHHHHHHHHHH Confidence 22446677777775533 688999874 3345566777887777642 123332211111 112234445555553 Q NP_000836.2 272 T-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 272 ~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) . .++++|++.. +..+..+++++++.++..++.+++ T Consensus 222 ~~~~~~~i~~~~-~~~~~~~~~~~~~~g~~~~v~i~~ 257 (342) T 4KVF_A 222 SYPNLKVIVSPT-TVGIAAASRYVSASSYKGKVAITG 257 (342) T ss_dssp HCTTEEEEEECS-HHHHHHHHHHHHTSTTTTTSEEEE T ss_pred HCCCccEEEEcC-hhHHHHHHHHHHHcCCCCceEEEE Confidence 1 2456666553 345566777777777632333443 No 238 >3EDC_D Lactose operon repressor; Lac-repressor, allosteric, tetramer, DNA-binding, Repressor; HET: HEZ; 2.1A {Escherichia coli K12} Probab=96.98 E-value=1.5e-06 Score=90.23 Aligned_cols=204 Identities=12% Similarity=0.068 Sum_probs=115.8 Template_Neff=11.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+.++||++.|..+. .++..+.++++.++++.+ +++.+...+. .++ +...+.+ T Consensus 57 ~~~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~~ 111 (360) T 3EDC_D 57 AGKQSLLIGVATSSLAL------------HAPSQIVAAIKSRADQLG--------ASVVVSMVER-SGV----EACKAAV 111 (360) T ss_dssp ----CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT--------CEEEEEECCT-TCH----HHHHHHH T ss_pred ccCCCCEEEEEeCCccC------------ccHHHHHHHHHHHHHHcC--------CEEEEEecCC-ChH----HHHHHHH Confidence 34578899999987542 255677788888887753 3444433332 221 1223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++|++|+...+.........+...++|+|..+...+ +.++.+..+.. T Consensus 112 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~ 164 (360) T 3EDC_D 112 HNLLA-------------------QRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQ--------TPINSIIFSHE 164 (360) T ss_dssp HHHHH-------------------TTCSEEEEESCCCHHHHHHHHHHTTTSCEEESSSCTT--------SSSCEEEECHH T ss_pred HHHHH-------------------CCCCEEEEeCCCCcHHHHHHHHHhcCCCEEEEcCCCC--------CCCCEEEEccH Confidence 43332 4788888764443322222235678999998765432 23455666666 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ..+..+++++.+.+.++++++.. ++.....+.++|++.+++. ++.+....... .+.......+++++.. .++|+ T Consensus 165 ~~~~~~~~~l~~~g~~~i~~l~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~d~ 241 (360) T 3EDC_D 165 DGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRN-QIQPIAEREGD--WSAMSGFQQTMQMLNEGIVPTA 241 (360) T ss_dssp HHHHHHHHHHHHHTCCCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCCSEEEECC--SSHHHHHHHHHHHHHTTCCCSE T ss_pred HHHHHHHHHHHHCCCCcEEEEeCCcccccHHHHHHHHHHHHHHC-CCCCceeeecC--CChhhHHHHHHHHHhcCCCCCE Confidence 66777777776667889999885 3445667788888888775 34443211111 1111223344444421 24777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 242 i~~~~-~~~a~~~~~~l~~~g~~ 263 (360) T 3EDC_D 242 MLVAN-DQMALGAMRAITESGLR 263 (360) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 76654 44566777888877764 No 239 >3KJX_D Transcriptional regulator, LacI family; Transcriptional regulator, Lacl family, Protein; 2.33A {Silicibacter pomeroyi} Probab=96.97 E-value=1.6e-06 Score=89.40 Aligned_cols=204 Identities=12% Similarity=0.070 Sum_probs=117.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 65 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~l~ 118 (344) T 3KJX_D 65 SNRVNLVAVIIPSLSN------------MVFPEVLTGINQVLEDTE--------L--QPVVGVTDYLP----EKEEKVLY 118 (344) T ss_dssp SSCCSEEEEEESCSSS------------SSHHHHHHHHHHHHTTSS--------C--EEEEEECTTCH----HHHHHHHH T ss_pred hCCCCeEEEEecCccc------------chHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 3567899999986532 245567778777776642 2 33344433332 22233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+....... .....+...++|+|..+.... .+..+.+..++.. T Consensus 119 ~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 171 (344) T 3KJX_D 119 EMLS-------------------WRPSGVIIAGLEHSE-AARAMLDAAGIPVVEIMDSDG-------KPVDAMVGISHRR 171 (344) T ss_dssp HHHT-------------------TCCSEEEEECSCCCS-HHHHHHHTCSSCEEEEEECSS-------CCSSCEEEECHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCCH-HHHHHHHHcCCCEEEEeCCCC-------CCcCceeEechHH Confidence 4332 467888765433322 344556678999998765321 2345566777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG---NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~---~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++.... .....+.++|++.+++. ++.+..........+..+....++++++. .++++ T Consensus 172 ~g~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 250 (344) T 3KJX_D 172 AGREMAQAILKAGYRRIGFMGTKMPLDYRARKRFEGFTEVLGKN-GVEIEDREFYSGGSALAKGREMTQAMLERSPDLDF 250 (344) T ss_dssp HHHHHHHHHHHTTCCSEEEEESSTTTCHHHHHHHHHHHHHHHHT-TCCCSEEEECCSCCCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHHcCCCcEEEEccCCCCChHHHHHHHHHHHHHHHC-CCCcCcceeecCCCcHHHHHHHHHHHHHhCCCCCE Confidence 788888888766888999988543 35566778888888775 34443211111011112233445555421 24666 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 251 i~~~~-~~~a~~~~~~l~~~g~~ 272 (344) T 3KJX_D 251 LYYSN-DMIAAGGLLYLLEQGID 272 (344) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 66553 44566777788777763 No 240 >3KJX_C Transcriptional regulator, LacI family; Transcriptional regulator, Lacl family, Protein; HET: MSE; 2.33A {Silicibacter pomeroyi} Probab=96.97 E-value=1.6e-06 Score=89.40 Aligned_cols=204 Identities=12% Similarity=0.070 Sum_probs=117.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 65 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~l~ 118 (344) T 3KJX_C 65 SNRVNLVAVIIPSLSN------------MVFPEVLTGINQVLEDTE--------L--QPVVGVTDYLP----EKEEKVLY 118 (344) T ss_dssp SSCCSEEEEEESCSSS------------SSHHHHHHHHHHHHHTSS--------C--EEEEEECTTCH----HHHHHHHH T ss_pred hCCCCeEEEEecCccc------------chHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 3567899999986532 245567778777776642 2 33344433332 22233444 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+....... .....+...++|+|..+.... .+..+.+..++.. T Consensus 119 ~l~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 171 (344) T 3KJX_C 119 EMLS-------------------WRPSGVIIAGLEHSE-AARAMLDAAGIPVVEIMDSDG-------KPVDAMVGISHRR 171 (344) T ss_dssp HHHT-------------------TCCSEEEEECSCCCH-HHHHHHHHCSSCEEEEEECTT-------CCSSEEEEECHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCCH-HHHHHHHHcCCCEEEEeCCCC-------CCcCceeEechHH Confidence 4332 467888765433322 344556678999998765321 2345566777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG---NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~---~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) .++.+++++.+.+.++++++.... .....+.++|++.+++. ++.+..........+..+....++++++. .++++ T Consensus 172 ~g~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 250 (344) T 3KJX_C 172 AGREMAQAILKAGYRRIGFMGTKMPLDYRARKRFEGFTEVLGKN-GVEIEDREFYSGGSALAKGREMTQAMLERSPDLDF 250 (344) T ss_dssp HHHHHHHHHHTTTCCSEEEECCSTTTCHHHHHHHHHHHHHHHTT-TCCEEEEECCSSCCCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHHcCCCcEEEEccCCCCChHHHHHHHHHHHHHHHC-CCCcCcceeecCCCcHHHHHHHHHHHHHhCCCCCE Confidence 788888888766888999988543 35566778888888775 34443211111011112233445555421 24666 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|.. T Consensus 251 i~~~~-~~~a~~~~~~l~~~g~~ 272 (344) T 3KJX_C 251 LYYSN-DMIAAGGLLYLLEQGID 272 (344) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 66553 44566777788777763 No 241 >1GLG_A GALACTOSE/GLUCOSE-BINDING PROTEIN COMPLEXED WITH D-GALACTOSE; GALACTOSE-BINDING PROTEIN; HET: GAL; 2.0A {Escherichia coli} SCOP: c.93.1.1 Probab=96.97 E-value=1.6e-06 Score=87.65 Aligned_cols=217 Identities=13% Similarity=0.037 Sum_probs=117.0 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ | +++.+.|+..+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~-------g--~~~~~~~~~~~~----~~~~~~~~~l~ 56 (309) T 1GLG_A 2 DTRIGVTIYKYDD------------NFMSVVRKAIEQDAKAAP-------D--VQLLMNDSQNDQ----SKQNDQIDVLL 56 (309) T ss_dssp CEEEEEEESCTTC------------HHHHHHHHHHHHHHHTCT-------T--EEEEEEECTTCH----HHHHHHHHHHH T ss_pred CcEEEEEEccCCC------------HHHHHHHHHHHHHHHhCC-------C--CeEEEecCCCCH----HHHHHHHHHHH Confidence 5789999987542 255677788888887653 2 234444443332 22233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++|+...+... ......+...++|+|..+...+.... ...++.+++.+++...+ T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 116 (309) T 1GLG_A 57 A-------------------KGVKALAINLVDPAAAGTVIEKARGQNVPVVFFNKEPSRKAL-DSYDKAYYVGTDSKESG 116 (309) T ss_dssp H-------------------TTCSEEEECCSSGGGHHHHHHHHHTTTCCEEEESSCCCHHHH-HTCTTEEEEECCHHHHH T ss_pred H-------------------CCCCEEEEeCCChhHHHHHHHHHhhCCCCEEEEccCCChhhc-ccCCcceEEecCcHHHH Confidence 2 477877764433322 23445566789999987764432110 01245667777776666 Q NP_000836.2 204 QAMVDIVT-A----L-------GWNYVSTLA--SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 204 ~~~~~~l~-~----~-------~~~~v~ii~--~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) +.+++++. + . +.++++++. .++.++..+.+++++.+++. ++.+........+....+....++++ T Consensus 117 ~~~~~~~~~~l~~~~g~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~ 195 (309) T 1GLG_A 117 IIQGDLIAKHWAANQGWDLNKDGQIQFVLLKGEPGHPDAEARTTYVIKELNDK-GIKTEQLQLDTAMWDTAQAKDKMDAW 195 (309) T ss_dssp HHHHHHHHHHHHHCGGGCTTCSSSEEEEEEECSTTCHHHHHHHHHHHHHHHHT-TCCEEEEEEEECTTCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHccCCccCCCCcEEEEEEEcCCCCccHHHHHHHHHHHHHhc-CCceeEeeccccCCCHHHHHHHHHHH Confidence 66654432 1 1 457788884 33445566777888877764 34432211111001112333445555 Q NP_000836.2 270 LET---PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 270 ~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ++. .++++|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 196 ~~~~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~~~v~~~~ 236 (309) T 1GLG_A 196 LSGPNANKIEVVIANN-DAMAMGAVEALKAHNKS-SIPVFGVD 236 (309) T ss_dssp TTSTTTTTCCEEEESS-HHHHHHHHHHHHHTTCT-TSCEECSB T ss_pred HcCCCCCCCCEEEECC-HHHHHHHHHHHHHCCCC-CCCEEEec Confidence 421 3567777664 44556678888877762 33444443 No 242 >2FVY_A D-galactose-binding periplasmic protein; PERIPLASMIC BINDING PROTIEN, HINGE, CHEMOTAXIS; HET: BGC; 0.92A {Escherichia coli} SCOP: c.93.1.1 Probab=96.97 E-value=1.6e-06 Score=87.65 Aligned_cols=217 Identities=13% Similarity=0.037 Sum_probs=117.0 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ | +++.+.|+..+. +...+.+++++ T Consensus 2 ~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~~-------g--~~~~~~~~~~~~----~~~~~~~~~l~ 56 (309) T 2FVY_A 2 DTRIGVTIYKYDD------------NFMSVVRKAIEQDAKAAP-------D--VQLLMNDSQNDQ----SKQNDQIDVLL 56 (309) T ss_dssp CEEEEEEESCTTS------------HHHHHHHHHHHHHHHTCT-------T--EEEEEEECTTCH----HHHHHHHHHHH T ss_pred CcEEEEEEccCCC------------HHHHHHHHHHHHHHHhCC-------C--CeEEEecCCCCH----HHHHHHHHHHH Confidence 5789999987542 255677788888887653 2 234444443332 22233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . ++++++|+...+... ......+...++|+|..+...+.... ...++.+++.+++...+ T Consensus 57 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 116 (309) T 2FVY_A 57 A-------------------KGVKALAINLVDPAAAGTVIEKARGQNVPVVFFNKEPSRKAL-DSYDKAYYVGTDSKESG 116 (309) T ss_dssp H-------------------TTCSEEEECCSSGGGHHHHHHHHHTTTCCEEEESSCCCHHHH-HTCTTEEEEECCHHHHH T ss_pred H-------------------CCCCEEEEeCCChhHHHHHHHHHhhCCCCEEEEccCCChhhc-ccCCcceEEecCcHHHH Confidence 2 477877764433322 23445566789999987764432110 01245667777776666 Q NP_000836.2 204 QAMVDIVT-A----L-------GWNYVSTLA--SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 204 ~~~~~~l~-~----~-------~~~~v~ii~--~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) +.+++++. + . +.++++++. .++.++..+.+++++.+++. ++.+........+....+....++++ T Consensus 117 ~~~~~~~~~~l~~~~g~~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~ 195 (309) T 2FVY_A 117 IIQGDLIAKHWAANQGWDLNKDGQIQFVLLKGEPGHPDAEARTTYVIKELNDK-GIKTEQLQLDTAMWDTAQAKDKMDAW 195 (309) T ss_dssp HHHHHHHHHHHHHCGGGCTTCSSSEEEEEEECSTTCHHHHHHHHHHHHHHHHT-TCCEEEEEEEECTTCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHccCCccCCCCcEEEEEEEcCCCCccHHHHHHHHHHHHHhc-CCceeEeeccccCCCHHHHHHHHHHH Confidence 66654432 1 1 457788884 33445566777888877764 34432211111001112333445555 Q NP_000836.2 270 LET---PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309 (908) Q Consensus 270 ~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~~ 309 (908) ++. .++++|++.. +..+..+++++++.|.. ++.+++.+ T Consensus 196 ~~~~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~-~~~v~~~~ 236 (309) T 2FVY_A 196 LSGPNANKIEVVIANN-DAMAMGAVEALKAHNKS-SIPVFGVD 236 (309) T ss_dssp HTSTTGGGCCEEEESS-HHHHHHHHHHHHHTTCT-TSCEECSB T ss_pred HcCCCCCCCCEEEECC-HHHHHHHHHHHHHCCCC-CCCEEEec Confidence 421 3567777664 44556678888877762 33444443 No 243 >3M9W_A D-xylose-binding periplasmic protein; xylose binding protein, xylose, conformational; 2.15A {Escherichia coli} Probab=96.97 E-value=1.6e-06 Score=87.92 Aligned_cols=211 Identities=9% Similarity=0.051 Sum_probs=115.4 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.... .++.....+++.++++.+ +++.+.|...++. ...+.+++++ T Consensus 2 ~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~~~~l~ 55 (313) T 3M9W_A 2 EVKIGMAIDDLRL------------ERWQKDRDIFVKKAESLG----------AKVFVQSANGNEE----TQMSQIENMI 55 (313) T ss_dssp -CEEEEEESCCSS------------STTHHHHHHHHHHHHHTS----------CEEEEEECTTCHH----HHHHHHHHHH T ss_pred CcEEEEEeCCCcc------------hHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999985422 245567778888777642 3444555443322 2233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+. .++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 110 (313) T 3M9W_A 56 N-------------------RGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMIND------ADIDFYISFDNEKVG 110 (313) T ss_dssp H-------------------TTCSEEEEECSSTTSCHHHHHHHHTTTCEEEEESSCCTT------SCCSEEEEECHHHHH T ss_pred H-------------------CCCCEEEEecCCcchHHHHHHHHHHCCCEEEEECCCCCC------CCccEEEECCHHHHH Confidence 2 46777765433322 224445566789999987654321 234466777777777 Q NP_000836.2 204 QAMVDIVTALG-WNYVSTLAS--EGNYGESGVEAFTQISREIG---GVCIAQSQKIPREPRPGEFEKIIKRLLET--PNA 275 (908) Q Consensus 204 ~~~~~~l~~~~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~---~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~ 275 (908) ..+++++.+.+ .++++++.. +..++..+.+++++.+++.+ .+.+....... ..+..+....++++++. .++ T Consensus 111 ~~~~~~l~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 189 (313) T 3M9W_A 111 ELQAKALVDIVPQGNYFLMGGSPVDNNAKLFRAGQMKVLKPYVDSGKIKVVGDQWVD-GWLPENALKIMENALTANNNKI 189 (313) T ss_dssp HHHHHHHHHHCSSEEEEEEESCTTCHHHHHHHHHHHHHHHHHHHTTSEEEEEEEECG-GGCHHHHHHHHHHHHHHTTTCC T ss_pred HHHHHHHHHhCCCCCEEEEeCCCCChhHHHHHHHHHHHHHHhHHcCCeEEEccccCC-CCCHHHHHHHHHHHHHHCCCCC Confidence 77888775544 345777764 23455667777877776642 02222111110 01112334445555421 357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~~~i~vig~ 221 (313) T 3M9W_A 190 DAVVASN-DATAGGAIQALSAQGLSGKVAISGQ 221 (313) T ss_dssp CEEEESS-HHHHHHHHHHHHTTTCTTTSEECCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCCCCcEEecC Confidence 7877664 4456677888887776323334433 No 244 >3MA0_A D-xylose-binding periplasmic protein; xylose binding protein, xylose, conformational; HET: XYP; 2.2A {Escherichia coli} Probab=96.97 E-value=1.6e-06 Score=87.92 Aligned_cols=211 Identities=9% Similarity=0.051 Sum_probs=115.9 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.... .++.....+++.++++.+ +++.+.|...++. ...+.+++++ T Consensus 2 ~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~~~~l~ 55 (313) T 3MA0_A 2 EVKIGMAIDDLRL------------ERWQKDRDIFVKKAESLG----------AKVFVQSANGNEE----TQMSQIENMI 55 (313) T ss_dssp CCEEEEEESCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECSSCHH----HHHHHHHHHH T ss_pred CcEEEEEeCCCcc------------hHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999985422 245567778888777642 3444555443322 2233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+. .++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 110 (313) T 3MA0_A 56 N-------------------RGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMIND------ADIDFYISFDNEKVG 110 (313) T ss_dssp H-------------------TTCSEEEECCSSTTSCHHHHHHHHHTTCEEEEESSCCCS------SCCSEEEEECHHHHH T ss_pred H-------------------CCCCEEEEecCCcchHHHHHHHHHHCCCEEEEECCCCCC------CCccEEEECCHHHHH Confidence 2 46777765433322 224445566789999987654321 234466777777777 Q NP_000836.2 204 QAMVDIVTALG-WNYVSTLAS--EGNYGESGVEAFTQISREIG---GVCIAQSQKIPREPRPGEFEKIIKRLLET--PNA 275 (908) Q Consensus 204 ~~~~~~l~~~~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~---~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~ 275 (908) ..+++++.+.+ .++++++.. +..++..+.+++++.+++.+ .+.+....... ..+..+....++++++. .++ T Consensus 111 ~~~~~~l~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 189 (313) T 3MA0_A 111 ELQAKALVDIVPQGNYFLMGGSPVDNNAKLFRAGQMKVLKPYVDSGKIKVVGDQWVD-GWLPENALKIMENALTANNNKI 189 (313) T ss_dssp HHHHHHHHHHCSSEEEEEEECCTTCHHHHHHHHHHHHHHHHHHHTTSEEEEEEEECG-GGCHHHHHHHHHHHHHHTTTCC T ss_pred HHHHHHHHHhCCCCCEEEEeCCCCChhHHHHHHHHHHHHHHhHHcCCeEEEccccCC-CCCHHHHHHHHHHHHHHCCCCC Confidence 77888775544 345777764 23455667777877776642 02222111110 01112334445555421 357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~~~i~vig~ 221 (313) T 3MA0_A 190 DAVVASN-DATAGGAIQALSAQGLSGKVAISGQ 221 (313) T ss_dssp CEEEESS-HHHHHHHHHHHHTTTCTTTSEECCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCCCCcEEecC Confidence 7877664 4456677888887776323334433 No 245 >3MA0_C D-xylose-binding periplasmic protein; xylose binding protein, xylose, conformational; HET: XYP; 2.2A {Escherichia coli} Probab=96.97 E-value=1.6e-06 Score=87.92 Aligned_cols=211 Identities=9% Similarity=0.051 Sum_probs=115.9 Template_Neff=11.500 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||+++|.... .++.....+++.++++.+ +++.+.|...++. ...+.+++++ T Consensus 2 ~~~Igvv~~~~~~------------~~~~~~~~g~~~a~~~~g----------~~l~~~~~~~~~~----~~~~~~~~l~ 55 (313) T 3MA0_C 2 EVKIGMAIDDLRL------------ERWQKDRDIFVKKAESLG----------AKVFVQSANGNEE----TQMSQIENMI 55 (313) T ss_dssp CCEEEEEECCSCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHHHHH T ss_pred CcEEEEEeCCCcc------------hHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCHH----HHHHHHHHHH Confidence 5789999985422 245567778888777642 3444555443322 2233344433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|....... .......+...++|+|..+...+. .++.+++..++...+ T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 110 (313) T 3MA0_C 56 N-------------------RGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMIND------ADIDFYISFDNEKVG 110 (313) T ss_dssp H-------------------HTCSEEEECCSSTTSCHHHHHHHHHTTCEEEEESSCCTT------SCCSEEEEECHHHHH T ss_pred H-------------------CCCCEEEEecCCcchHHHHHHHHHHCCCEEEEECCCCCC------CCccEEEECCHHHHH Confidence 2 46777765433322 224445566789999987654321 234466777777777 Q NP_000836.2 204 QAMVDIVTALG-WNYVSTLAS--EGNYGESGVEAFTQISREIG---GVCIAQSQKIPREPRPGEFEKIIKRLLET--PNA 275 (908) Q Consensus 204 ~~~~~~l~~~~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~---~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~ 275 (908) ..+++++.+.+ .++++++.. +..++..+.+++++.+++.+ .+.+....... ..+..+....++++++. .++ T Consensus 111 ~~~~~~l~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~ 189 (313) T 3MA0_C 111 ELQAKALVDIVPQGNYFLMGGSPVDNNAKLFRAGQMKVLKPYVDSGKIKVVGDQWVD-GWLPENALKIMENALTANNNKI 189 (313) T ss_dssp HHHHHHHHHHCCSEEEEEEECCTTCHHHHHHHHHHHHHHHHHHHTTSEEEEEEEECG-GGCHHHHHHHHHHHHHHTTTCC T ss_pred HHHHHHHHHhCCCCCEEEEeCCCCChhHHHHHHHHHHHHHHhHHcCCeEEEccccCC-CCCHHHHHHHHHHHHHHCCCCC Confidence 77888775544 345777764 23455667777877776642 02222111110 01112334445555421 357 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|++.. +..+..+++++++.|+..++.+++. T Consensus 190 d~i~~~~-~~~a~~~~~~~~~~g~~~~i~vig~ 221 (313) T 3MA0_C 190 DAVVASN-DATAGGAIQALSAQGLSGKVAISGQ 221 (313) T ss_dssp CEEEESS-HHHHHHHHHHHHTTTCTTTSEECCC T ss_pred CEEEECC-hHHHHHHHHHHHHCCCCCCcEEecC Confidence 7877664 4456677888887776323334433 No 246 >5IBQ_A Probable ribose ABC transporter, substrate-binding; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: XXM; 1.2A {Rhizobium etli} Probab=96.97 E-value=1.6e-06 Score=87.77 Aligned_cols=217 Identities=10% Similarity=0.036 Sum_probs=115.8 Template_Neff=11.500 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....++..+||+++|..+. .++.....+++.++++.+ +++.+.+...++ +... T Consensus 17 ~~~~~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~ 70 (310) T 5IBQ_A 17 NLYFQSMADLIAIITPAHDN------------PFFKAEAVGAEAKAKELG----------YETLVMTHDDDA----NKQS 70 (310) T ss_dssp ------CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHH T ss_pred ccceeeCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCH----HHHH Confidence 34556788999999997542 255667778888777642 334444443332 2223 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .+++++|+...... .......+.+.++|+|..+...+. ..++++++. T Consensus 71 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~ 126 (310) T 5IBQ_A 71 EMIDTAIG-------------------RGAKAIILDNAGADASVAAVKKAKDAGIPSFLIDREINA-----TGVAVAQIV 126 (310) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSCTTTTHHHHHHHHHTTCCEEEESSCCSC-----SSSSSEEEE T ss_pred HHHHHHHH-------------------CCCCEEEEeCCCchhhHHHHHHHHHCCCCEEEeCCCCCC-----CCCceEEEE Confidence 33343332 46787776443332 223344566789999987754321 123456677 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWN--YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~--~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) .+....++.+++++.+.+.+ +++++.. +..++..+.+++++.+++.+...+....... .+..+....++++++ T Consensus 127 ~d~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~ 204 (310) T 5IBQ_A 127 SNNYQGAQLGAQEFVKLMGEKGNYVELVGKESDTNAGIRSQGYHDVIDDYPEMKSVAKQSAN--WSQTEAYSKMETILQA 204 (310) T ss_dssp ECHHHHHHHHHHHHHHHTTTCEEEEEEECCTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred cChHHHHHHHHHHHHHHhCCcceEEEEEcCCCChhHHHHHHHHHHHHHHCCCeEEEEEeeCC--CCHHHHHHHHHHHHHH Confidence 77777777888887654433 3555553 2344566777888877764212221111111 111223344455542 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ..++++|++.. +..+..+++++++.|.. ++.+++. T Consensus 205 ~~~~~~i~~~~-~~~a~~~~~al~~~g~~-~i~vv~~ 239 (310) T 5IBQ_A 205 NPDIKGVISGN-DTMAMGAIAALQAAGRK-DVIVVGF 239 (310) T ss_dssp CCSCCEEEESS-HHHHHHHHHHHHHTTCT-TSEEECS T ss_pred CCCCCEEEECC-hHHHHHHHHHHHHCCCC-CcEEEEe Confidence 13577776654 44566777788777762 3344443 No 247 >3K9C_B Transcriptional regulator, LacI family protein; PSI-II, 11026W, LacI family protein; HET: GOL; 2.14A {Rhodococcus jostii} Probab=96.96 E-value=1.7e-06 Score=86.50 Aligned_cols=201 Identities=16% Similarity=0.153 Sum_probs=116.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++++||++.|.++ .++.....+++.++++.+ +++.+.++..+ . ...+.+ T Consensus 8 ~~~~~~~I~~i~~~~~-------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~-~----~~~~~~ 59 (289) T 3K9C_B 8 RQASSRLLGVVFELQQ-------------PFHGDLVEQIYAAATRRG----------YDVMLSAVAPS-R----AEKVAV 59 (289) T ss_dssp -CCSSEEEEEEEETTC-------------HHHHHHHHHHHHHHHHTT----------EEEEEEEEBTT-B----CHHHHH T ss_pred hhCCCCeEEEEeCCCC-------------hhHHHHHHHHHHHHHHCC----------CeEEEEeCCCC-H----HHHHHH Confidence 3457899999987543 245667788888877653 23334443322 1 122333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++.. .++|++|+...+.....+ ..+ ..++|+|..+...+ .+..+.+..++. T Consensus 60 ~~l~~-------------------~~~d~ii~~~~~~~~~~~-~~~-~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 111 (289) T 3K9C_B 60 QALMR-------------------ERCEAAILLGTRFDTDEL-GAL-ADRVPALVVARASG-------LPGVGAVRGDDV 111 (289) T ss_dssp HHHHT-------------------TTEEEEEEETCCCCHHHH-HHH-HTTSCEEEESSCCC-------STTSEEEEECHH T ss_pred HHHHh-------------------CCCCEEEEECCCCCHHHH-HHH-hcCCCEEEEeccCC-------CCCCcEEEeCcH Confidence 33332 478888876543332222 233 46899888765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~vi 278 (908) ..++.+++++.+.+.++++++... +.++..+.++|++.+++. ++.+....... ..+..+....++++++. .++|+| T Consensus 112 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~d~i 189 (289) T 3K9C_B 112 AGITLAVDHLTELGHRNIAHIDGADAPGGADRRAGFLAAMDRH-GLSASATVVTG-GTTETEGAEGMHTLLEMPTPPTAV 189 (289) T ss_dssp HHHHHHHHHHHHTTCCSEEEEECTTSTTHHHHHHHHHHHHHHT-TCGGGEEEEEC-CSSHHHHHHHHHHHHHSSSCCSEE T ss_pred HHHHHHHHHHHHCCCCcEEEeeCCCCCChHHHHHHHHHHHHHc-CCCCCCcEEeC-CCChHHHHHHHHHHhcCCCCCCEE Confidence 777788888766678899999853 345667778888887764 34433211111 01112233445555421 247887 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 190 ~~~~-~~~a~~~~~~l~~~g~~ 210 (289) T 3K9C_B 190 VAFN-DRCATGVLDLLVRSGRD 210 (289) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHCCCC Confidence 7664 44566778888877764 No 248 >4RY8_B Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: SR1; 1.75A {Thermotoga lettingae TMO} Probab=96.95 E-value=1.7e-06 Score=88.41 Aligned_cols=215 Identities=9% Similarity=0.041 Sum_probs=118.1 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.+ +++.+.+...++ +...+. T Consensus 10 ~~~~~~~~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~ 63 (329) T 4RY8_B 10 FENPKNVRIALVREVGEG------------SFFERYLAGAQSMARELG----------VTLLEATAHGDM----ARMVTM 63 (329) T ss_dssp GGSGGGCEEEEEESCCCS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHHHH T ss_pred cCCCCCcEEEEEEeCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHHHH Confidence 456678999999997542 245667778888877642 334444543332 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+ .+.++.+.++ T Consensus 64 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d 117 (329) T 4RY8_B 64 IENFIT-------------------QRVDAIIIDHGRPDPLMPKIKEALDRGIRVVTFDLVVD-------DNRVPEIEQD 117 (329) T ss_dssp HHHHHH-------------------TTCSEEEEESCCHHHHHHHHHHHHHHTCEEEEESCCCS-------CTTSCEEECC T ss_pred HHHHHh-------------------cCCCEEEECCCCccccHHHHHHHHHCCCEEEEECCCCC-------CCCCcEEecC Confidence 443332 47887776443332 22344556778999998776432 2345667777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLASEGNYGESGVEAFTQISREI-GGVCIAQSQK-IPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~i~v~~~~~-~~~~~~~~~~~~~~~~l~~-~~ 273 (908) ....++.+++++.+ .+.++++++..+..++......+.+.+.+. .++.+..... ... .+..+....++++++ .. T Consensus 118 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~l~~~~ 196 (329) T 4RY8_B 118 DLLIGYLISKQLAVDFAGNANVIYVNVGGFAPLDKRDKMWQIIKWRFPGIKEVAKIGAVTG-STAADTQTRMEAAMKEKP 196 (329) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEECCSSSHHHHHHHHHHHHHHHHCTTEEEEEEECCCCS-SHHHHHHHHHHHHHHHCT T ss_pred hHHHHHHHHHHHHHHcCCCceEEEEEcCCCccHHHHHHHHHHHHHHCCCcEEEEEEcCCCC-CCHHHHHHHHHHHHHHCC Confidence 77777788877755 577899998754434433444444444331 1233321110 110 111233344555542 12 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|++.. +..+..+++++++.|+..++.+++. T Consensus 197 ~~~~I~~~~-~~~a~~~~~al~~~g~~~~v~v~~~ 230 (329) T 4RY8_B 197 EANAVLAMW-DEFAKGAVRAIMQAGKSDQFKVYSV 230 (329) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHHTCGGGCEEEEE T ss_pred CCCEEEEcC-hHHHHHHHHHHHHcCCCCceEEEEe Confidence 467776553 4456678888887776423334443 No 249 >4RY8_C Periplasmic binding protein/LacI transcriptional regulator; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: SR1; 1.75A {Thermotoga lettingae TMO} Probab=96.95 E-value=1.7e-06 Score=88.41 Aligned_cols=215 Identities=9% Similarity=0.041 Sum_probs=117.0 Template_Neff=11.300 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++.++||++.|..+. .++.....+++.++++.+ +++.+.+...++ +...+. T Consensus 10 ~~~~~~~~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~ 63 (329) T 4RY8_C 10 FENPKNVRIALVREVGEG------------SFFERYLAGAQSMARELG----------VTLLEATAHGDM----ARMVTM 63 (329) T ss_dssp C--CTTCEEEEEESCCCS------------HHHHHHHHHHHHHHHHHT----------CEEEEEECTTCH----HHHHHH T ss_pred cCCCCCcEEEEEEeCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeCCCCH----HHHHHH Confidence 456678999999997542 245667778888877642 334444543332 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+ .+.++.+.++ T Consensus 64 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d 117 (329) T 4RY8_C 64 IENFIT-------------------QRVDAIIIDHGRPDPLMPKIKEALDRGIRVVTFDLVVD-------DNRVPEIEQD 117 (329) T ss_dssp HHHHHH-------------------TTCSEEEEESCCHHHHHHHHHHHHHTTCEEEEESCCCS-------CTTSCEEECC T ss_pred HHHHHh-------------------cCCCEEEECCCCccccHHHHHHHHHCCCEEEEECCCCC-------CCCCcEEecC Confidence 443332 47887776443332 22344556778999998776432 2345667777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLASEGNYGESGVEAFTQISREI-GGVCIAQSQK-IPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~-~~i~v~~~~~-~~~~~~~~~~~~~~~~l~~-~~ 273 (908) ....++.+++++.+ .+.++++++..+..++......+.+.+.+. .++.+..... ... .+..+....++++++ .. T Consensus 118 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~l~~~~ 196 (329) T 4RY8_C 118 DLLIGYLISKQLAVDFAGNANVIYVNVGGFAPLDKRDKMWQIIKWRFPGIKEVAKIGAVTG-STAADTQTRMEAAMKEKP 196 (329) T ss_dssp HHHHHHHHHHHHHHHTTTCEEEEEECCSSCHHHHHHHHHHHHHHHHCTTEEEEEEECCCCS-SHHHHHHHHHHHHHHHCT T ss_pred hHHHHHHHHHHHHHHcCCCceEEEEEcCCCccHHHHHHHHHHHHHHCCCcEEEEEEcCCCC-CCHHHHHHHHHHHHHHCC Confidence 77777788877755 577899998754434433444444444331 1233321110 110 111233344555542 12 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|++.. +..+..+++++++.|+..++.+++. T Consensus 197 ~~~~I~~~~-~~~a~~~~~al~~~g~~~~v~v~~~ 230 (329) T 4RY8_C 197 EANAVLAMW-DEFAKGAVRAIMQAGKSDQFKVYSV 230 (329) T ss_dssp TCCEEEESS-HHHHHHHHHHHHHHTCGGGCEEEEE T ss_pred CCCEEEEcC-hHHHHHHHHHHHHcCCCCceEEEEe Confidence 467776553 4456678888887776423334443 No 250 >3ROT_A ABC sugar transporter, periplasmic sugar; NYSGRC, PSI-BIOLOGY, Structural Genomics, New; HET: GOL; 1.91A {Legionella pneumophila subsp. pneumophila} Probab=96.93 E-value=1.9e-06 Score=86.61 Aligned_cols=205 Identities=8% Similarity=0.085 Sum_probs=118.1 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) .+++||++.|.... .++.....+++.++++. |+++.+...|+..++ +...+.++++ T Consensus 2 ~~~~I~vi~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~v~~~~~~~~~~~----~~~~~~~~~l 57 (297) T 3ROT_A 2 VRDKYYLITHGSQD------------PYWTSLFQGAKKAAEEL--------KVDLQILAPPGANDV----PKQVQFIESA 57 (297) T ss_dssp -CCEEEEECSCCCS------------HHHHHHHHHHHHHHHHH--------TCEEEEECCSSSCCH----HHHHHHHHHH T ss_pred CCcEEEEEccCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEECCCCCCCH----HHHHHHHHHH Confidence 46789999985332 24566778888888775 345655555433332 2233344443 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. .+++++|+.. .+.........+...++|+|..+...+... ..++++++.+++... T Consensus 58 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~d~~~~ 115 (297) T 3ROT_A 58 LA-------------------TYPSGIATTIPSDTAFSKSLQRANKLNIPVIAVDTRPKDKT---KNPYLVFLGSDNLLA 115 (297) T ss_dssp HH-------------------TCCSEEEECCCCSSTTHHHHHHHHHHTCCEEEESCCCSCTT---TSCCSCEEECCHHHH T ss_pred HH-------------------hCCCEEEEeCCChHHHHHHHHHHHHCCCCEEEEcCCCCCCC---CCCceeEEeCChHHH Confidence 32 4788777643 222222445556678999998776543211 124567777777777 Q NP_000836.2 203 AQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 203 ~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ++.+++++.+. +.++++++.. ++.++..+.+++++.+++. ++.+... ... .+..+....+++++.. .++++ T Consensus 116 ~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-g~~~~~~-~~~--~~~~~~~~~~~~~~~~~~~~~~ 191 (297) T 3ROT_A 116 GKKLGEKALELTPSAKRALVLNPQPGHIGLEKRAYGIKTILQDK-GIFFEEL-DVG--TDPNQVQSRVKSYFKIHPETNI 191 (297) T ss_dssp HHHHHHHHHHHCTTCCEEEEEESCTTCHHHHHHHHHHHHHHHHT-TCEEEEE-ECC--SCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHhCCCCCeEEEEcCCCCchhHHHHHHHHHHHHHhc-CCeEEEE-eCC--CCHHHHHHHHHHHHHHCCCccE Confidence 88888887665 6789999975 3345667778888888765 3444321 111 1122333445555421 23566 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~ 299 (908) |++.. +..+..+++++++.|. T Consensus 192 i~~~~-~~~a~~~~~~~~~~g~ 212 (297) T 3ROT_A 192 IFCLT-SQALDPLGQMLLHPDR 212 (297) T ss_dssp EEESS-HHHHHHHHHHHHSHHH T ss_pred EEECC-hhhhHHHHHHhhCCCC Confidence 65553 3445566666666553 No 251 >3ROT_B ABC sugar transporter, periplasmic sugar; NYSGRC, PSI-BIOLOGY, Structural Genomics, New; HET: MSE, GOL; 1.91A {Legionella pneumophila subsp. pneumophila} Probab=96.93 E-value=1.9e-06 Score=86.61 Aligned_cols=205 Identities=8% Similarity=0.085 Sum_probs=118.1 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) .+++||++.|.... .++.....+++.++++. |+++.+...|+..++ +...+.++++ T Consensus 2 ~~~~I~vi~~~~~~------------~~~~~~~~g~~~a~~~~--------g~~v~~~~~~~~~~~----~~~~~~~~~l 57 (297) T 3ROT_B 2 VRDKYYLITHGSQD------------PYWTSLFQGAKKAAEEL--------KVDLQILAPPGANDV----PKQVQFIESA 57 (297) T ss_dssp -CCEEEEECSCCSS------------HHHHHHHHHHHHHHHHH--------TCEEEEECCSSSCCH----HHHHHHHHHH T ss_pred CCcEEEEEccCCCC------------HHHHHHHHHHHHHHHHh--------CCEEEEECCCCCCCH----HHHHHHHHHH Confidence 46789999985332 24566778888888775 345655555433332 2233344443 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. .+++++|+.. .+.........+...++|+|..+...+... ..++++++.+++... T Consensus 58 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~d~~~~ 115 (297) T 3ROT_B 58 LA-------------------TYPSGIATTIPSDTAFSKSLQRANKLNIPVIAVDTRPKDKT---KNPYLVFLGSDNLLA 115 (297) T ss_dssp HT-------------------TCCSEEEECCCCSSSSHHHHHHHHHTTCCEEEESCCCSCTT---TSCCSCEEECCHHHH T ss_pred HH-------------------hCCCEEEEeCCChHHHHHHHHHHHHCCCCEEEEcCCCCCCC---CCCceeEEeCChHHH Confidence 32 4788777643 222222445556678999998776543211 124567777777777 Q NP_000836.2 203 AQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARA 277 (908) Q Consensus 203 ~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~v 277 (908) ++.+++++.+. +.++++++.. ++.++..+.+++++.+++. ++.+... ... .+..+....+++++.. .++++ T Consensus 116 ~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-g~~~~~~-~~~--~~~~~~~~~~~~~~~~~~~~~~ 191 (297) T 3ROT_B 116 GKKLGEKALELTPSAKRALVLNPQPGHIGLEKRAYGIKTILQDK-GIFFEEL-DVG--TDPNQVQSRVKSYFKIHPETNI 191 (297) T ss_dssp HHHHHHHHHHHCTTCCEEEEEESSTTCHHHHHHHHHHHHHHHHT-TCEEEEE-ECC--SCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHhCCCCCeEEEEcCCCCchhHHHHHHHHHHHHHhc-CCeEEEE-eCC--CCHHHHHHHHHHHHHHCCCccE Confidence 88888887665 6789999975 3345667778888888765 3444321 111 1122333445555421 23566 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~ 299 (908) |++.. +..+..+++++++.|. T Consensus 192 i~~~~-~~~a~~~~~~~~~~g~ 212 (297) T 3ROT_B 192 IFCLT-SQALDPLGQMLLHPDR 212 (297) T ss_dssp EEESS-HHHHHHHHHHHHSHHH T ss_pred EEECC-hhhhHHHHHHhhCCCC Confidence 65553 3445566666666553 No 252 >5BRA_A Putative periplasmic binding protein with; Periplasmic solute binding Protein, ENZYME; HET: MSE; 2.971A {Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)} Probab=96.93 E-value=1.9e-06 Score=89.01 Aligned_cols=220 Identities=8% Similarity=-0.032 Sum_probs=122.4 Template_Neff=10.800 Q NP_000836.2 37 AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQS 116 (908) Q Consensus 37 ~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~ 116 (908) .......+.++||++.|..+. .++.....+++.++++.+ +++.+...+. .++ +.. T Consensus 36 ~~~~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~v~~~~~~~-~~~----~~~ 90 (350) T 5BRA_A 36 LITTANDKKYTIATVVKVDGI------------AWFDRMRDGVDQFKADTG--------NDVWMVGPSQ-ADA----AAQ 90 (350) T ss_pred HHHhhcCCCeEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CEEEEEeCCC-CCH----HHH Confidence 344556788999999997542 255677888888887763 3444432222 222 223 Q NP_000836.2 117 LTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRV 195 (908) Q Consensus 117 ~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~ 195 (908) .+.+++++. .+++++|+...+.. .......+.+.++|+|..+...+. ...++++ T Consensus 91 ~~~~~~l~~-------------------~~~d~iI~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v 145 (350) T 5BRA_A 91 VQIVENLIA-------------------QGVDAIAIVPFSVEAVEPVLKKARERGIVVISHEASNIQ------NVDYDIE 145 (350) T ss_pred HHHHHHHHH-------------------CCCCEEEECCCChHHHHHHHHHHHHCCCCEEEeCCCCCC------CCCeEEE Confidence 334444332 47888776543322 224455667789999877654321 1334556 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLL 270 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~ 270 (908) .+++...+..+++++.+. +.++++++.. ++.++..+.+++++.+++.+ ++.+.... .....+..+....+++++ T Consensus 146 ~~d~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~l 224 (350) T 5BRA_A 146 AFDNKAYGANLMKELGKSMGGKGKYVTTVGSLTSKSQMEWIDGAVEYQKANFPEMSEATGR-LETYDDANTDYNKLKEAM 224 (350) T ss_pred CCCHHHHHHHHHHHHHHHhCCCcEEEEEeCCCCCHHHHHHHHHHHHHHHHHCCCeEEEEee-cCCCCCHHHHHHHHHHHH Confidence 667666677777777543 5788999885 34456667778887776531 13322110 000011123334455554 Q NP_000836.2 271 ET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 271 ~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) +. .++++|++.. +..+..+++++++.|+..++.+++. T Consensus 225 ~~~~~~~~i~~~~-~~~a~~~~~al~~~g~~~~v~v~g~ 262 (350) T 5BRA_A 225 TAYPDITGILGAP-MPTSAGAGRLIAEGGLKGKVFFAGT 262 (350) T ss_pred HHCCCCCEEEEcC-hhHHHHHHHHHHHCCCCCCeEEEEe Confidence 21 2456665543 4456678888888776423344443 No 253 >2H3H_A Sugar ABC transporter, periplasmic sugar-binding; glucose binding protein, periplasmic binding; HET: BGC; 1.7A {Thermotoga maritima} Probab=96.93 E-value=1.9e-06 Score=87.35 Aligned_cols=209 Identities=10% Similarity=0.057 Sum_probs=113.2 Template_Neff=11.300 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.+. .++.....+++.++++.+ +++.+...+ ..++ +...+.+++++ T Consensus 1 ~~~Ig~i~~~~~-------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~-~~~~----~~~~~~~~~l~ 54 (313) T 2H3H_A 1 MLTIGVIGKSVH-------------PYWSQVEQGVKAAGKALG--------VDTKFFVPQ-KEDI----NAQLQMLESFI 54 (313) T ss_dssp CCEEEEECSCSS-------------HHHHHHHHHHHHHHHHHT--------CEEEEECCS-SSCH----HHHHHHHHHHH T ss_pred CeEEEEEcCCCC-------------hHHHHHHHHHHHHHHHhC--------CEEEEECCC-ccCH----HHHHHHHHHHH Confidence 367899998642 245667788888887753 333332211 1221 12233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|+...+... ......+...++|+|..+...+. .++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 109 (313) T 2H3H_A 55 A-------------------EGVNGIAIAPSDPTAVIPTIKKALEMGIPVVTLDTDSPD------SGRYVYIGTDNYQAG 109 (313) T ss_dssp H-------------------TTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHHHHH T ss_pred H-------------------cCCCEEEECCCChHhhHHHHHHHHHCCCCEEEECCCCCC------CCcceEEeCChHHHH Confidence 2 477877764433322 23445567789999887654321 234566777777777 Q NP_000836.2 204 QAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 204 ~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) +.+++++.+. +.++++++.. ++.++..+.++|.+.+++. ++.+....... .+..+....++++++ ..++++| T Consensus 110 ~~~~~~l~~~~~g~~~i~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ai 186 (313) T 2H3H_A 110 YTAGLIMKELLGGKGKVVIGTGSLTAMNSLQRIQGFKDAIKDS-EIEIVDILNDE--EDGARAVSLAEAALNAHPDLDAF 186 (313) T ss_dssp HHHHHHHHHHHTSCSEEEEEESCSSCHHHHHHHHHHHHHHTTS-SCEEEEEEECS--SCHHHHHHHHHHHHHHCTTCCEE T ss_pred HHHHHHHHHHhCCCeEEEEEeCCCCchHHHHHHHHHHHHHhcC-CcEEEEEEcCC--CCHHHHHHHHHHHHHHCCCCCEE Confidence 7888877654 6788988875 3345667788888887764 34433211111 111122333445442 1257777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++... .....++.++++.+...++.+++. T Consensus 187 ~~~~~-~~~~~~~~~~~~~~~~~~v~iig~ 215 (313) T 2H3H_A 187 FGVYA-YNGPAQALVVKNAGKVGKVKIVCF 215 (313) T ss_dssp EECST-THHHHHHHHHHHTTCTTTSEEEEE T ss_pred EEcCC-CChHHHHHHHHHCCCCCCeEEEEe Confidence 66542 233444555555554323334433 No 254 >2H3H_B Sugar ABC transporter, periplasmic sugar-binding; glucose binding protein, periplasmic binding; HET: BGC; 1.7A {Thermotoga maritima} Probab=96.93 E-value=1.9e-06 Score=87.35 Aligned_cols=209 Identities=10% Similarity=0.057 Sum_probs=113.2 Template_Neff=11.300 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|.+. .++.....+++.++++.+ +++.+...+ ..++ +...+.+++++ T Consensus 1 ~~~Ig~i~~~~~-------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~-~~~~----~~~~~~~~~l~ 54 (313) T 2H3H_B 1 MLTIGVIGKSVH-------------PYWSQVEQGVKAAGKALG--------VDTKFFVPQ-KEDI----NAQLQMLESFI 54 (313) T ss_dssp CCEEEEECSCSS-------------HHHHHHHHHHHHHHHHHT--------CEEEEECCS-SCCH----HHHHHHHHHHH T ss_pred CeEEEEEcCCCC-------------hHHHHHHHHHHHHHHHhC--------CEEEEECCC-ccCH----HHHHHHHHHHH Confidence 367899998642 245667788888887753 333332211 1221 12233344333 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++|+...+... ......+...++|+|..+...+. .++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~~~~ 109 (313) T 2H3H_B 55 A-------------------EGVNGIAIAPSDPTAVIPTIKKALEMGIPVVTLDTDSPD------SGRYVYIGTDNYQAG 109 (313) T ss_dssp H-------------------HTCSEEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCTT------SCCSCEEECCHHHHH T ss_pred H-------------------cCCCEEEECCCChHhhHHHHHHHHHCCCCEEEECCCCCC------CCcceEEeCChHHHH Confidence 2 477877764433322 23445567789999887654321 234566777777777 Q NP_000836.2 204 QAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 204 ~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) +.+++++.+. +.++++++.. ++.++..+.++|.+.+++. ++.+....... .+..+....++++++ ..++++| T Consensus 110 ~~~~~~l~~~~~g~~~i~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~ai 186 (313) T 2H3H_B 110 YTAGLIMKELLGGKGKVVIGTGSLTAMNSLQRIQGFKDAIKDS-EIEIVDILNDE--EDGARAVSLAEAALNAHPDLDAF 186 (313) T ss_dssp HHHHHHHHHHTTTEEEEEEEESCSSSHHHHHHHHHHHHHTTTS-EEEEEEEEECS--SCHHHHHHHHHHHHHHCTTCCEE T ss_pred HHHHHHHHHHhCCCeEEEEEeCCCCchHHHHHHHHHHHHHhcC-CcEEEEEEcCC--CCHHHHHHHHHHHHHHCCCCCEE Confidence 7888877654 6788988875 3345667788888887764 34433211111 111122333445442 1257777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++... .....++.++++.+...++.+++. T Consensus 187 ~~~~~-~~~~~~~~~~~~~~~~~~v~iig~ 215 (313) T 2H3H_B 187 FGVYA-YNGPAQALVVKNAGKVGKVKIVCF 215 (313) T ss_dssp EECST-THHHHHHHHHHHTTCBTTBEEEEE T ss_pred EEcCC-CChHHHHHHHHHCCCCCCeEEEEe Confidence 66542 233444555555554323334433 No 255 >3GBV_A Putative LacI-family transcriptional regulator; NYSGXRC, PSI-II, 11231j, transcriptional regulator; HET: EDO; 2.2A {Bacteroides fragilis} Probab=96.93 E-value=1.9e-06 Score=86.77 Aligned_cols=155 Identities=18% Similarity=0.140 Sum_probs=94.8 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++.++||++.|.+... .++.....+++.++++.|.. +.++++...|.. ++ ....+.++ T Consensus 5 ~~~~~~Ig~i~~~~~~~-----------~~~~~~~~g~~~~~~~~~~~-----~~~i~~~~~~~~-~~----~~~~~~~~ 63 (304) T 3GBV_A 5 SNKKYTFACLLPKHLEG-----------EYWTDVQKGIREAVTTYSDF-----NISANITHYDPY-DY----NSFVATSQ 63 (304) T ss_dssp --CCEEEEEEEECCCTT-----------SHHHHHHHHHHHHHHHTGGG-----CEEEEEEEECSS-CH----HHHHHHHH T ss_pred cCCCeEEEEEccccCCC-----------hhHHHHHHHHHHHHHhhhhc-----CeEEEEecCCCC-CH----HHHHHHHH Confidence 45789999999864321 25567888999998887632 234444444432 22 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +++. +++|++|....+.. .......+...++|+|..+...+. .++++.+.++.. T Consensus 64 ~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 118 (304) T 3GBV_A 64 AVIE-------------------EQPDGVMFAPTVPQYTKGFTDALNELGIPYIYIDSQIKD------APPLAFFGQNSH 118 (304) T ss_dssp HHHT-------------------TCCSEEEECCSSGGGTHHHHHHHHHHTCCEEEESSCCTT------SCCSEEEECCHH T ss_pred HHHH-------------------hCCCEEEECCCChhhhHHHHHHHHHcCCCEEEEcCCCCC------CCCcEEEcCChH Confidence 4332 46787765433322 223345566789999987764431 235667777777 Q NP_000836.2 201 YQAQAMVDIVTAL--GWNYVSTLAS------EGNYGESGVEAFTQISREI 242 (908) Q Consensus 201 ~~~~~~~~~l~~~--~~~~v~ii~~------~~~~~~~~~~~~~~~~~~~ 242 (908) ..++.+++++.+. +.++++++.. +..++..+.+++++.+++. T Consensus 119 ~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 168 (304) T 3GBV_A 119 QSGYFAARMLMLLAVNDREIVIFRKIHEGVIGSNQQESREIGFRQYMQEH 168 (304) T ss_dssp HHHHHHHHHHHHHSTTCSEEEEEEEEBTTBCCCHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHccCCCeEEEEEeccCCCCCChHHHHHHHHHHHHHHHH Confidence 7788888887654 7789999873 2345566778888877664 No 256 >3HUU_A Transcription regulator like protein; PSI-II, NYSGXRC, 11235m, transcription regulator; 1.95A {Staphylococcus haemolyticus} Probab=96.89 E-value=2.3e-06 Score=86.17 Aligned_cols=205 Identities=13% Similarity=0.116 Sum_probs=115.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|.++.... ...++.....+++.++++.+ + ++.+.+...++ +...+.+ T Consensus 18 ~~~~~~~Ig~i~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 76 (305) T 3HUU_A 18 ITNKTLTIGLIQKSSAPEIR-------QNPFNSDVLNGINQACNVRG--------Y--STRMTVSENSG----DLYHEVK 76 (305) T ss_dssp ---CCCEEEEECSCCSHHHH-------TSHHHHHHHHHHHHHHHHHT--------C--EEEECCCSSHH----HHHHHHH T ss_pred HcCCCcEEEEEEcCCChhHh-------cCccHHHHHHHHHHHHHHhC--------C--eEEEEEcCCCc----chHHHHH Confidence 34678999999987642100 01345667788888777642 3 33334433321 1222233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. +++|++|+...+.. ......+...++|+|..+...+ .+.++++.++.. T Consensus 77 ~~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 129 (305) T 3HUU_A 77 TMIQS-------------------KSVDGFILLYSLKD-DPIEHLLNEFKVPYLIVGKSLN-------YENIIHIDNDNI 129 (305) T ss_dssp HHHHT-------------------TCCSEEEESSCBTT-CHHHHHHHHTTCCEEEESCCCS-------STTCCEEECCHH T ss_pred HHHHh-------------------CCCCEEEEeccCCC-ChHHHHHHHcCCCEEEECCCCC-------CCCCcEEecChH Confidence 32221 47888886554433 2445566778999998765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~~~ 276 (908) ..++.+++++.+.+.++++++..... ....+.++|++.+++. ++.+.... .. +..+....+++++ ...++| T Consensus 130 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~~~~~~~~d 204 (305) T 3HUU_A 130 DAAYQLTQYLYHLGHRHILFLQESGHYAVTEDRSVGFKQYCDDV-KISNDCVV-IK---SMNDLRDFIKQYCIDASHMPS 204 (305) T ss_dssp HHHHHHHHHHHHTTCCSEEEEEESSCBHHHHHHHHHHHHHHHHT-TCCCCEEE-EC---SHHHHHHHC--------CCCS T ss_pred HHHHHHHHHHHHcCCCeEEEEeCCCCchhHHHHHHHHHHHHHHc-CCCcceEE-Ec---chhhHHHHHHHHHHHcCCCCc Confidence 77888888887678889999985432 3466778888887764 34332111 11 1123334444442 123678 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +|++.. +..+..+++++++.|+ T Consensus 205 ~i~~~~-~~~a~~~~~~l~~~g~ 226 (305) T 3HUU_A 205 VIITSD-VMLNMQLLNVLYEYQL 226 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTC T ss_pred EEEECC-HHHHHHHHHHHHHcCC Confidence 775553 4456778888887776 No 257 >3HUU_C Transcription regulator like protein; PSI-II, NYSGXRC, 11235m, transcription regulator; 1.95A {Staphylococcus haemolyticus} Probab=96.89 E-value=2.3e-06 Score=86.17 Aligned_cols=205 Identities=13% Similarity=0.116 Sum_probs=116.7 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|.++.... ...++.....+++.++++.+ + ++.+.+...++ +...+.+ T Consensus 18 ~~~~~~~Ig~i~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 76 (305) T 3HUU_C 18 ITNKTLTIGLIQKSSAPEIR-------QNPFNSDVLNGINQACNVRG--------Y--STRMTVSENSG----DLYHEVK 76 (305) T ss_dssp ---CCCEEEEECSCCCHHHH-------TSHHHHHHHHHHHHHHHHTT--------C--EEEECCCSSHH----HHHHHHH T ss_pred HcCCCcEEEEEEcCCChhHh-------cCccHHHHHHHHHHHHHHhC--------C--eEEEEEcCCCc----chHHHHH Confidence 34678999999987642100 01345667788888777642 3 33334433321 1222233 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. +++|++|+...+.. ......+...++|+|..+...+ .+.++++.++.. T Consensus 77 ~~~~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~ 129 (305) T 3HUU_C 77 TMIQS-------------------KSVDGFILLYSLKD-DPIEHLLNEFKVPYLIVGKSLN-------YENIIHIDNDNI 129 (305) T ss_dssp HHHHT-------------------TCCSEEEESSCBTT-CHHHHHHHHTTCCEEEESCCCS-------CSSCCEEECCHH T ss_pred HHHHh-------------------CCCCEEEEeccCCC-ChHHHHHHHcCCCEEEECCCCC-------CCCCcEEecChH Confidence 32221 47888886554433 2445566778999998765432 134566777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL--ETPNAR 276 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~--~~~~~~ 276 (908) ..++.+++++.+.+.++++++..... ....+.++|++.+++. ++.+.... .. +..+....+++++ ...++| T Consensus 130 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~~~~~~~~d 204 (305) T 3HUU_C 130 DAAYQLTQYLYHLGHRHILFLQESGHYAVTEDRSVGFKQYCDDV-KISNDCVV-IK---SMNDLRDFIKQYCIDASHMPS 204 (305) T ss_dssp HHHHHHHHHHHHHTCCCEEEEEESSCBHHHHHHHHHHHHHHHHT-TCCCCEEE-EC---SHHHHHHHHTTC------CCS T ss_pred HHHHHHHHHHHHcCCCeEEEEeCCCCchhHHHHHHHHHHHHHHc-CCCcceEE-Ec---chhhHHHHHHHHHHHcCCCCc Confidence 77888888887678889999985432 3466778888887764 34332111 11 1123334444442 123678 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~ 299 (908) +|++.. +..+..+++++++.|+ T Consensus 205 ~i~~~~-~~~a~~~~~~l~~~g~ 226 (305) T 3HUU_C 205 VIITSD-VMLNMQLLNVLYEYQL 226 (305) T ss_dssp EEEESS-HHHHHHHHHHHHHTTC T ss_pred EEEECC-HHHHHHHHHHHHHcCC Confidence 775553 4456778888887776 No 258 >3KKE_C LacI family Transcriptional regulator; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: ACT; 2.2A {Mycobacterium smegmatis str. MC2 155} Probab=96.87 E-value=2.5e-06 Score=85.91 Aligned_cols=205 Identities=12% Similarity=0.124 Sum_probs=117.5 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .++..+..+++.++++. |++ +.+.+.. +. ....+. T Consensus 10 l~~~~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~--~~~~~~~-~~----~~~~~~ 62 (303) T 3KKE_C 10 LRHSRSGTIGLIVPDVNN------------AVFADMFSGVQMAASGH--------STD--VLLGQID-AP----PRGTQQ 62 (303) T ss_dssp CCTTCSCEEEEECSCTTS------------TTHHHHHHHHHHHHHHT--------TCE--EEEECCC-ST----THHHHH T ss_pred HhcCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHhcC--------CCE--EEEEeCC-CC----hhHHHH Confidence 345678999999987542 24566777887777664 233 3333322 21 112223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +.+++. ..++|++|+...+.........+ ..++|+|..+...+ +..+.+..++ T Consensus 63 ~~~~~~------------------~~~~d~ii~~~~~~~~~~~~~~~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 115 (303) T 3KKE_C 63 LSRLVS------------------EGRVDGVLLQRREDFDDDMLAAV-LEGVPAVTINSRVP--------GRVGSVILDD 115 (303) T ss_dssp HHHHHH------------------TTSCSEEEEECCTTCCHHHHHHH-HTTSCEEEESCCCT--------TSCCEEEECH T ss_pred HHHHHH------------------cCCCCEEEEeccccCCHHHHHHH-HhCCCEEEeCCCCC--------CCCCEEEeCc Confidence 333322 14688888654433222333444 67999998776432 1355677777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE------ 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~------ 271 (908) ...++.+++++.+.+.++++++..+. .....+.++|++.+++. ++.+.....+..+.+..+..+.++++++ T Consensus 116 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 194 (303) T 3KKE_C 116 QKGGGIATEHLITLGHSRIAFISGTAIHDTAQRRKEGYLETLASA-GLRSEAAWVVDAGWEADAGSAALNTLYRGANLGK 194 (303) T ss_dssp HHHHHHHHHHHHHHTCCCEEEECSCTTCHHHHHHHHHHHHHHHHH-TCCCCGGGEECCCSSHHHHHHHHHHHHHHSCTTS T ss_pred hHHHHHHHHHHHHcCCCcEEEEeCCCCChHHHHHHHHHHHHHHHc-CCCCCceeEEecCCChHHHHHHHHHHHhhcCCCC Confidence 77888888888777888999998543 35566778888888765 3332211111100111223344444432 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 195 ~~~~~~i~~~~-~~~a~~~~~a~~~~g~~ 222 (303) T 3KKE_C 195 PDGPTAVVVAS-VNAAVGALSTALRLGLR 222 (303) T ss_dssp TTSCSEEEESS-HHHHHHHHHHHHHHTCC T ss_pred CCCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 13577777664 44566778888877763 No 259 >3KKE_B LacI family Transcriptional regulator; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: ACT; 2.2A {Mycobacterium smegmatis str. MC2 155} Probab=96.87 E-value=2.5e-06 Score=85.91 Aligned_cols=205 Identities=12% Similarity=0.124 Sum_probs=117.5 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .++..+..+++.++++. |++ +.+.+.. +. ....+. T Consensus 10 l~~~~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~--~~~~~~~-~~----~~~~~~ 62 (303) T 3KKE_B 10 LRHSRSGTIGLIVPDVNN------------AVFADMFSGVQMAASGH--------STD--VLLGQID-AP----PRGTQQ 62 (303) T ss_dssp HHHTCCSEEEEECSCTTS------------TTHHHHHHHHHHHHHHT--------TCE--EEEECCC-ST----THHHHH T ss_pred HhcCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHhcC--------CCE--EEEEeCC-CC----hhHHHH Confidence 345678999999987542 24566777887777664 233 3333322 21 112223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +.+++. ..++|++|+...+.........+ ..++|+|..+...+ +..+.+..++ T Consensus 63 ~~~~~~------------------~~~~d~ii~~~~~~~~~~~~~~~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 115 (303) T 3KKE_B 63 LSRLVS------------------EGRVDGVLLQRREDFDDDMLAAV-LEGVPAVTINSRVP--------GRVGSVILDD 115 (303) T ss_dssp HHHHHH------------------TTSCSCEEECCCTTCCHHHHHHH-HTTSCEEEESCCCT--------TSCCEEEECH T ss_pred HHHHHH------------------cCCCCEEEEeccccCCHHHHHHH-HhCCCEEEeCCCCC--------CCCCEEEeCc Confidence 333322 14688888654433222333444 67999998776432 1355677777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE------ 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~------ 271 (908) ...++.+++++.+.+.++++++..+. .....+.++|++.+++. ++.+.....+..+.+..+..+.++++++ T Consensus 116 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ 194 (303) T 3KKE_B 116 QKGGGIATEHLITLGHSRIAFISGTAIHDTAQRRKEGYLETLASA-GLRSEAAWVVDAGWEADAGSAALNTLYRGANLGK 194 (303) T ss_dssp HHHHHHHHHHHHHTTCCSEEEEESCTTCHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHHHHCTTS T ss_pred hHHHHHHHHHHHHcCCCcEEEEeCCCCChHHHHHHHHHHHHHHHc-CCCCCceeEEecCCChHHHHHHHHHHHhhcCCCC Confidence 77888888888777888999998543 35566778888888765 3332211111100111223344444432 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 195 ~~~~~~i~~~~-~~~a~~~~~a~~~~g~~ 222 (303) T 3KKE_B 195 PDGPTAVVVAS-VNAAVGALSTALRLGLR 222 (303) T ss_dssp TTSCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 13577777664 44566778888877763 No 260 >3BBL_A Regulatory protein of LacI family; Protein Structure Initiative II, PSI-II; HET: EDO; 2.35A {Chloroflexus aggregans} Probab=96.86 E-value=2.6e-06 Score=84.93 Aligned_cols=146 Identities=13% Similarity=0.134 Sum_probs=85.5 Template_Neff=11.700 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|+...... ......+...++|+|..+...+ .+..+.+.+++...++.+++++.+.+.++++++..+ T Consensus 63 ~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~~~~~~~~l~~~g~~~i~~i~~~ 134 (287) T 3BBL_A 63 GNVDGFVLSSINYN-DPRVQFLLKQKFPFVAFGRSNP-------DWDFAWVDIDGTAGTRQAVEYLIGRGHRRIAILAWP 134 (287) T ss_dssp TCCSEEEECSCCTT-CHHHHHHHHTTCCEEEESCCST-------TCCCCEEEECHHHHHHHHHHHHHHHTCCCEEEEECC T ss_pred CCCCEEEEecCCCC-CHHHHHHHhCCCCEEEeCCCCC-------CCCCcEEEeChHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 47888887544332 2344556678999998775432 123556667777777788888866678899998844 Q NP_000836.2 225 G--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET---PNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 225 ~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~---~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) . .....+.+++.+.+++. ++.+..........+..+....++++++. .++|+|++.. +..+..+++++++.|+ T Consensus 135 ~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~i~~~~-~~~~~~~~~~l~~~g~ 212 (287) T 3BBL_A 135 EDSRVGNDRLQGYLEAMQTA-QLPIETGYILRGEGTFEVGRAMTLHLLDLSPERRPTAIMTLN-DTMAIGAMAAARERGL 212 (287) T ss_dssp TTCHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHTSCTTTSCSEEEESS-HHHHHHHHHHHHHTTC T ss_pred ccchHHHHHHHHHHHHHHHC-CCCCCCcceeccCCCHHHHHHHHHHHHccCCCCCCCEEEECC-HHHHHHHHHHHHHCCC Confidence 2 24556677788777764 33322111111001111233334444321 2467777664 4456778888888776 Q NP_000836.2 300 S 300 (908) Q Consensus 300 ~ 300 (908) . T Consensus 213 ~ 213 (287) T 3BBL_A 213 T 213 (287) T ss_dssp C T ss_pred C Confidence 4 No 261 >4PZ0_A sugar ABC transporter, sugar-binding protein; structural genomics, The Center for; HET: PAV, EDO; 1.25A {Bacillus anthracis} Probab=96.85 E-value=2.8e-06 Score=86.62 Aligned_cols=213 Identities=13% Similarity=0.078 Sum_probs=116.2 Template_Neff=11.400 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILD-TCSRDTYALEQSLTF 119 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d-~~~~~~~a~~~~~~~ 119 (908) ...+.++||++.|..+. .++..+..+++.++++. |++ +.+.+ +..++ ....+. T Consensus 6 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~--~~~~~~~~~~~----~~~~~~ 59 (324) T 4PZ0_A 6 KKADDVKFAFIPKLTGV------------GFFTSGGEGAKEMGDKL--------GVQ--VKYDGPSEASV----SGQVKY 59 (324) T ss_dssp SCGGGCEEEEECSSSSS------------HHHHHHHHHHHHHHHHH--------TCE--EEECCCSSCCH----HHHHHH T ss_pred hccCCcEEEEEeCCCCC------------hHHHHHHHHHHHHHHHH--------CCE--EEEECCCCCCH----HHHHHH Confidence 45678999999986542 25567778888887764 233 33344 22232 223334 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++|+...+.. .......+...++|+|..+...+. ....+.+..+ T Consensus 60 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~ 114 (324) T 4PZ0_A 60 INNFIN-------------------QNYDALMVSSTSVDGLSQSLQRAKKKGMTVLTWDSDVNP------KDRSFYISQG 114 (324) T ss_dssp HHHHHH-------------------TTCSEEEECCSCSSTTHHHHHHHHHTTCEEEEESSCCCG------GGCSEEEESC T ss_pred HHHHHh-------------------cCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCc------ccCcEEEecC Confidence 444332 47888776543332 224455677789999987764431 1122333344 Q NP_000836.2 199 D-SYQAQAMVDIVTAL-G-WNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 199 ~-~~~~~~~~~~l~~~-~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) + ...++.+++++.+. + .++++++.. ++.+...+.+++++.+++.+ ++++....... .+..+....+++++.. T Consensus 115 ~~~~~g~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~ 192 (324) T 4PZ0_A 115 TPDQLANLLIEMTSKQIGDKGKVAFFYSSPTVTDQNQWVTKAKEIIKEKYPNWEIVTTQYGE--NNAQKSLSVGENILKT 192 (324) T ss_dssp CHHHHHHHHHHHHHHHHTTCEEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHCCCeeEEEEEcCCCCHHHHHHHHHHHHHHHHHCCCcEEeeeccCC--CCHHHHHHHHHHHHHH Confidence 3 45566777777543 4 678988874 33455667777887776521 13332211111 1112334445555421 Q NP_000836.2 273 -PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 -~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++. ++..+..+++++++.|+..++.+++ T Consensus 193 ~~~~~~i~~~-~~~~a~~~~~al~~~g~~~~i~v~g 227 (324) T 4PZ0_A 193 YPDINAVICP-DATALPAMAQAAENLKMDKKVVVTG 227 (324) T ss_dssp CTTCCEEEEC-STTHHHHHHHHHHHTTCBTTBEEEE T ss_pred CCCCCEEEec-CCcchHHHHHHHHHCCCCCCeEEEE Confidence 246666655 3445667778888777632333443 No 262 >4YS6_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER, SOLUTE-BINDING PROTEIN, ENZYME; HET: BGC, MSE; 1.698A {Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)} Probab=96.85 E-value=2.8e-06 Score=88.09 Aligned_cols=217 Identities=9% Similarity=0.018 Sum_probs=115.7 Template_Neff=11.100 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.|..+. .++.....+++.++++.| +++.+.|...+. +...+. T Consensus 31 ~~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~l~~~~~~~~~----~~~~~~ 84 (360) T 4YS6_A 31 SGKGSDKLVGVAMPTKDL------------QRWNQDGSNMEKQLKDAG----------YEVDLQYASNDV----QTQVSQ 84 (360) T ss_dssp ------CEEEEEESCSSS------------THHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHH T ss_pred CCCCCCcEEEEEecCCCC------------HHHHhhHHHHHHHHHHcC----------CEEEEEeCCCCH----HHHHHH Confidence 456678999999987542 245567778887777653 344445544332 222333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAA-SSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~-s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++++|.... +.........+...++|+|..+...+. ..++.+++.++ T Consensus 85 i~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d 140 (360) T 4YS6_A 85 IENMIS-------------------NGCKLLVIASIEGDSLGTVLAQAKKKGISVIAYDRLIMN-----SDAVSYYATFD 140 (360) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTSCHHHHHHHHHTTCEEEEESSCCCS-----CTTCCEEEEEC T ss_pred HHHHHH-------------------CCCCEEEEeCCCcccHHHHHHHHHHCCCEEEEECCCCCC-----CCcccEEEEeC Confidence 444332 46777765432 222234455667789999987654331 12346677777 Q NP_000836.2 199 DSYQAQAMVDIVTAL-------GWNYVSTLAS--EGNYGESGVEAFTQISREIGG--VCIAQS------QKIPREPRPGE 261 (908) Q Consensus 199 ~~~~~~~~~~~l~~~-------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~--i~v~~~------~~~~~~~~~~~ 261 (908) +...++.+++++.+. +.++++++.. ++.++..+.+++++.+++.++ +.+... .......+..+ T Consensus 141 ~~~~~~~~~~~l~~~~~~~~~~g~~~v~~i~~~~~~~~~~~r~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~ 220 (360) T 4YS6_A 141 NYMVGTKQGEYIKEKLNLETAKGPFNLEIFTGDPGDNNARFFYGGAMDVLKPYVDGGVLVVKSGSVAFEKVATAGWSTET 220 (360) T ss_dssp HHHHHHHHHHHHHHHTTTTTCCCCEEEEEEBCCTTCHHHHHHHHHHHHHHHHHHHTTSEECTTCCCSHHHHBCGGGCHHH T ss_pred hHHHHHHHHHHHHHHhccccCCCCceEEEEEcCCCChhHHHHHhHHHHHhHhhcCCCeEEEecCceeeeeeccCCCCHHH Confidence 777777777777543 6779999985 345566777888887766421 221100 00000011111 Q NP_000836.2 262 FEKIIKRLLET-----PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 262 ~~~~~~~l~~~-----~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) ....+++++.+ .++|+|++.. +..+..+++++++.|+..++.+++ T Consensus 221 ~~~~~~~~l~~~~~~~~~~d~i~~~~-~~~a~~~~~al~~~g~~~~i~v~~ 270 (360) T 4YS6_A 221 AQNRMDAIIASYYADGTKLDAVLCSN-DSTALGVTNALTASYKGEWPIVTG 270 (360) T ss_dssp HHHHHHHHHHHHSSSSCCCCEEEESS-HHHHHHHHHHHHHHCCSSCCEECC T ss_pred HHHHHHHHHHHhhccCCCceEEEECC-hHHHHHHHHHHHHcCCCCCCEEEE Confidence 11223333211 3567776654 445667788888777632333443 No 263 >3L49_C ABC sugar (Ribose) transporter, periplasmic; SUGAR BINDING/TRANSPORTER, STRUCTURAL GENOMICS, PSI; HET: UNL; 2.3A {Rhodobacter sphaeroides} Probab=96.84 E-value=2.9e-06 Score=84.69 Aligned_cols=203 Identities=12% Similarity=0.091 Sum_probs=110.6 Template_Neff=11.900 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++.++||++.|.... ........+++.++++.| +++.+.|+..++. ...+.+++ T Consensus 3 ~~~~~Ig~~~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~~~~~~~~~~~~----~~~~~~~~ 56 (291) T 3L49_C 3 LEGKTIGITAIGTDH------------DWDLKAYQAQIAEIERLG----------GTAIALDAGRNDQ----TQVSQIQT 56 (291) T ss_dssp CTTCEEEEEESCCCS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECCSCHH----HHHHHHHH T ss_pred CCCcEEEEEecCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCHH----HHHHHHHH Confidence 467899999985432 234456667776666543 3444555443322 22233443 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++. ++++++|+.. .+.........+...++|+|..+...+ ..++++.+++.. T Consensus 57 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~~~~~ 109 (291) T 3L49_C 57 LIA-------------------QKPDAIIEQLGNLDVLNPWLQKINDAGIPLFTVDTATP--------HAINNTTSNNYS 109 (291) T ss_dssp HHH-------------------TCCSEEEEECCCHHHHHHHHHHHHHTTCCEEEESCCCT--------TCSEEEECCHHH T ss_pred HHH-------------------cCCCEEEEcCCChhhhHHHHHHHHHCCCCEEEeCCCCC--------CccceeccChHH Confidence 332 4788888653 333323445556778999998775432 134555555555 Q NP_000836.2 202 QAQAM-VDIVTALGWN-YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIP-REPRPGEFEKIIKRLLET-P-- 273 (908) Q Consensus 202 ~~~~~-~~~l~~~~~~-~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~-~~~~~~~~~~~~~~l~~~-~-- 273 (908) .+..+ ..++.+.+.+ +++++.. ++.++..+.+++++.+++.+++++....... ...+..+....++++++. . T Consensus 110 ~~~~~~~~~~~~~g~~~~v~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 189 (291) T 3L49_C 110 IGAELALQMVADLGGKGNVLVFNGFYSVPVCKIRYDQMKYVLEAFPDVKIIEPELRDVIPNTIQSAYSNVTDMLTKYPNE 189 (291) T ss_dssp HHHHHHHHHHHHTTTCEEEEEECTTTTSHHHHHHHHHHHHHHTTCTTEEECSSCBCCCSSSHHHHHHHHHHHHHHHCCST T ss_pred HHHHHHHHHHHHhCCCceEEEEEcCCCCHHHHHHHHHHHHHHHHCCCcEEeccccccCCCCCHHHHHHHHHHHHHHCCCC Confidence 55433 3444555666 7888875 3445666777887777653223332211000 001112334445555431 1 Q NP_000836.2 274 -NARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 274 -~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++++|++.. +..+..+++++++.|+ T Consensus 190 ~~~dai~~~~-~~~a~~~~~~l~~~g~ 215 (291) T 3L49_C 190 GDVGAIWACW-DVPMIGATQALQAAGR 215 (291) T ss_dssp TSCCEEEESS-SHHHHHHHHHHHHHTC T ss_pred CCccEEEEcC-CHHHHHHHHHHHHCCC Confidence 567777664 4456677888887776 No 264 >3JY6_A Transcriptional regulator, LacI family; NYSGXRC, PSI-II, transcriptional regulator, Lac; 1.97A {Lactobacillus brevis} Probab=96.83 E-value=3e-06 Score=83.95 Aligned_cols=199 Identities=11% Similarity=0.090 Sum_probs=113.6 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|..+. .++.....+++.++++.+ + ++.+.+...+. ....+.++ T Consensus 4 ~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 57 (276) T 3JY6_A 4 TQSSKLIAVIVANIDD------------YFSTELFKGISSILESRG--------Y--IGVLFDANADI----EREKTLLR 57 (276) T ss_dssp -CCCCEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCccEEEEEEcCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 4567899999986532 245567778887776643 2 23344443332 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. .++|++|+...+.. .....+...++|+|..+...+ .+..+.+..++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 109 (276) T 3JY6_A 58 AIGS-------------------RGFDGLILQSFSNP--QTVQEILHQQMPVVSVDREMD-------ACPWPQVVTDNFE 109 (276) T ss_dssp HHHT-------------------TTCSEEEEESSCCH--HHHHHHHTTSSCEEEESCCCT-------TCSSCEEECCHHH T ss_pred HHHH-------------------cCCCEEEEecCCCc--HHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 3332 47888887544332 233445678999988765432 1245566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNY---GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~---~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .++.+++++.+.+.++++++.....+ ...+.+++.+.+++. ++.......+ +..+....+++++. ..++++ T Consensus 110 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~----~~~~~~~~~~~~l~~~~~~~~ 184 (276) T 3JY6_A 110 AAKAATTAFRQQGYQHVVVLTSELELSRTRQERYRGILAAAQDV-DVLEVSESSY----NHSEVHQRLTQLITQNDQKTV 184 (276) T ss_dssp HHHHHHHHHHTTTCCEEEEEEECSTTCHHHHHHHHHHHTTCSEE-EEEEECSSSC----CHHHHHHHHHHHHHSSSSCEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCccccchhHHHHHHHHHHHHHhC-CCeEeeccCC----CHHHHHHHHHHHHhcCCCCcE Confidence 77788888766678899998854332 455667777776654 3322111111 11223344555542 135677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 185 i~~~~-~~~a~~~~~~l~~~g~~ 206 (276) T 3JY6_A 185 AFALK-ERWLLEFFPNLIISGLI 206 (276) T ss_dssp EEESS-HHHHHHHSHHHHHSSSC T ss_pred EEEcC-hHHHHHHHHHHHHcCCC Confidence 76653 44566677777777763 No 265 >3JY6_D Transcriptional regulator, LacI family; NYSGXRC, PSI-II, transcriptional regulator, Lac; 1.97A {Lactobacillus brevis} Probab=96.83 E-value=3e-06 Score=83.95 Aligned_cols=199 Identities=11% Similarity=0.090 Sum_probs=111.5 Template_Neff=11.700 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|..+. .++.....+++.++++.+ + ++.+.+...+. ....+.++ T Consensus 4 ~~~~~~Ig~~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 57 (276) T 3JY6_D 4 TQSSKLIAVIVANIDD------------YFSTELFKGISSILESRG--------Y--IGVLFDANADI----EREKTLLR 57 (276) T ss_dssp ----CEEEEEESCTTS------------HHHHHHHHHHHHHHHTTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCccEEEEEEcCCCC------------hHHHHHHHHHHHHHHHcC--------C--EEEEEeCCCCH----HHHHHHHH Confidence 4567899999986532 245567778887776643 2 23344443332 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. .++|++|+...+.. .....+...++|+|..+...+ .+..+.+..++.. T Consensus 58 ~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 109 (276) T 3JY6_D 58 AIGS-------------------RGFDGLILQSFSNP--QTVQEILHQQMPVVSVDREMD-------ACPWPQVVTDNFE 109 (276) T ss_dssp HHHH-------------------TTCSEEEECSSCCH--HHHHHHSCSCCCEEEESSCCS-------SCSSCEEEECHHH T ss_pred HHHH-------------------cCCCEEEEecCCCc--HHHHHHHhCCCCEEEeCCCCC-------CCCCCeEEeChHH Confidence 3332 47888887544332 233445678999988765432 1245566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGNY---GESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~~---~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) .++.+++++.+.+.++++++.....+ ...+.+++.+.+++. ++.......+ +..+....+++++. ..++++ T Consensus 110 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~----~~~~~~~~~~~~l~~~~~~~~ 184 (276) T 3JY6_D 110 AAKAATTAFRQQGYQHVVVLTSELELSRTRQERYRGILAAAQDV-DVLEVSESSY----NHSEVHQRLTQLITQNDQKTV 184 (276) T ss_dssp HHHHHHHHHHTTTCCEEEEEEECGGGCHHHHHHHHHHHTTCSEE-EEEEECTTCC-----CHHHHHHHHHHHHSSCCCEE T ss_pred HHHHHHHHHHHCCCCEEEEEcCccccchhHHHHHHHHHHHHHhC-CCeEeeccCC----CHHHHHHHHHHHHhcCCCCcE Confidence 77788888766678899998854332 455667777776654 3322111111 11223344555542 135677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 185 i~~~~-~~~a~~~~~~l~~~g~~ 206 (276) T 3JY6_D 185 AFALK-ERWLLEFFPNLIISGLI 206 (276) T ss_dssp EEESS-HHHHHHHSHHHHHSSCC T ss_pred EEEcC-hHHHHHHHHHHHHcCCC Confidence 76653 44566677777777763 No 266 >5HQJ_A Periplasmic binding protein/LacI transcriptional regulator; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: 64K, MSE; 1.55A {Burkholderia graminis C4D1M} Probab=96.83 E-value=3e-06 Score=85.67 Aligned_cols=204 Identities=10% Similarity=0.095 Sum_probs=114.8 Template_Neff=11.700 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+.++||++.+.+. .++..+..+++.++++.+ +++.+...++ .++ +...+. T Consensus 23 ~~~~~~~~Ig~~~~~~~-------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~-~~~----~~~~~~ 76 (311) T 5HQJ_A 23 MKDAKDISVAVIPKVAV-------------PFFDDCNKGAKTAADKAG--------VKYQWVVPQN-TQG----STQVQI 76 (311) T ss_dssp CCCGGGCEEEEECSSSC-------------TTHHHHHHHHHHHHHHHT--------CEEEECCCSS-SSS----HHHHHH T ss_pred cccCCCceEEEecCCCC-------------HHHHHHHHHHHHHHHHHC--------CEEEEECCCC-CCH----HHHHHH Confidence 34567899999665432 245677888888888763 3444433332 221 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. ++++++| ++..+.........+...++|+|..+...+. .++.+++.++ T Consensus 77 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d 131 (311) T 5HQJ_A 77 IEDLIS-------------------RHVDGIAISVNEPKSVESVMKRAEQSGIKVLTYDSDSPK------SGRSMYIGTN 131 (311) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTGGGHHHHHHHHTTTCEEEEESSCCTT------SCCSCEEECC T ss_pred HHHHHH-------------------cCCCEEEEcCCCHHHHHHHHHHHHHcCCeEEEEcCCCCC------CCCcEEEecC Confidence 444332 4678775 4443333233445566789999987764321 2456677777 Q NP_000836.2 199 DSYQAQAMVDIVTA--LGWNYVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273 (908) Q Consensus 199 ~~~~~~~~~~~l~~--~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~ 273 (908) ....++.+++++.+ .+.++++++.. +..+...+.+++++.+++..++++....... .+..+....+++++. .. T Consensus 132 ~~~~~~~~~~~l~~~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 209 (311) T 5HQJ_A 132 NEQAGATMAETMGKALNGQGEVAIITGQLGAVNLNERIAGIKKGLAKYPGIKVVETQGTD--DDLARGVSVVETTLRAHP 209 (311) T ss_dssp HHHHHHHHHHHHHHHTTTEEEEEEECSCTTCHHHHHHHHHHHHHHTTCTEEEEEEEECCT--TCHHHHHHHHHHHHHHCT T ss_pred HHHHHHHHHHHHHHHcCCCeeEEEEECCCCCccHHHHHHHHHHHHHhCCCcEEEEecCCC--ccHHHHHHHHHHHHHHCC Confidence 77778888888765 57789999985 3445666777888877653124443221111 111223344444442 12 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++++|++.. +..+..+++++++. T Consensus 210 ~~~~i~~~~-~~~a~~~~~~~~~~ 232 (311) T 5HQJ_A 210 NLKGIFGVS-QVGGPAVAKVLNTR 232 (311) T ss_dssp TEEEEEECS-TTHHHHHHHHHTST T ss_pred CccEEEEec-CCcHHHHHHHHHHH Confidence 567776654 33445566666543 No 267 >3EJW_A SmLsrB; Periplasmic binding protein, Plasmid, SIGNALING; HET: PAV; 1.8A {Sinorhizobium meliloti} Probab=96.81 E-value=3.3e-06 Score=85.59 Aligned_cols=211 Identities=10% Similarity=-0.016 Sum_probs=114.6 Template_Neff=11.400 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.+ +++.+...+ ..++ +...+.+++++ T Consensus 1 ~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~~-~~~~----~~~~~~~~~l~ 55 (315) T 3EJW_A 1 ENQIAFIPKLVGV------------GFFTSGGAGAVKAGEEVG--------AKVTYDGPT-EPSV----SGQVQFINNFV 55 (315) T ss_dssp CCEEEEECSCSSS------------HHHHHHHHHHHHHHHHHT--------CEEEECCCS-SCCH----HHHHHHHHHHH T ss_pred CcEEEEEeccCCC------------hHHHHHHHHHHHHHHHHC--------CEEEEECCC-CCCH----HHHHHHHHHHH Confidence 3689999987652 255677888888888763 334333221 2222 22333444443 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP-PDSYQ 202 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~-~~~~~ 202 (908) . ++++++|+...+.. .......+...++|+|..+...+. ....+.+.. +.... T Consensus 56 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~~~~~~ 110 (315) T 3EJW_A 56 N-------------------QGYNALIVSSVSPDGLCPALKRAMERGVLVMTWDSDVNP------DCRSYYINQGTPEQL 110 (315) T ss_dssp H-------------------TTCSEEEECCSCSSTTHHHHHHHHHTTCEEEEESSCCCG------GGCSEEEESCCHHHH T ss_pred H-------------------cCCCEEEEcCCChhhhHHHHHHHHHCCCEEEEEcCCCCc------ccccEEEeCCCHHHH Confidence 2 47888776543322 224455667789999987764431 111222333 45555 Q NP_000836.2 203 AQAMVDIVTAL--G-WNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNA 275 (908) Q Consensus 203 ~~~~~~~l~~~--~-~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~ 275 (908) ++.+++++.+. + .++++++.. ++.++..+.++|++.+++.+ ++++....... .+..+....++++++ ..++ T Consensus 111 g~~~~~~l~~~~~~~~~~i~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~ 188 (315) T 3EJW_A 111 GGLLVDMAAEGVKKEKAKVAFFYSSPTVTDQNAWAEAAKAKIAKEHPGWEIVTTQYGY--NDAQKSLQTAESILQTYPDL 188 (315) T ss_dssp HHHHHHHHHHHHCCSSEEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCTTC T ss_pred HHHHHHHHHHHcccCCCcEEEEEcCCCcHHHHHHHHHHHHHHHHHCCCcEEeecccCC--CCHHHHHHHHHHHHHHCCCC Confidence 66777776443 3 688998875 34456667778888776531 23332211111 111233344555542 1256 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++|+... +..+..+++++++.|+..++.+++. T Consensus 189 ~~i~~~~-~~~a~~~~~al~~~g~~~~v~v~~~ 220 (315) T 3EJW_A 189 DAIIAPD-ANALPAAAQAAENLKRAEGVTIVGF 220 (315) T ss_dssp CEEEECS-TTHHHHHHHHHHHHTCTTTCEEEEB T ss_pred CEEEeCC-CCchHHHHHHHHHcccCCCCEEEEe Confidence 6666553 4456677888888776323444443 No 268 >3QK7_C Transcriptional regulators; STRUCTURAL GENOMICS, NEW YORK STRUCTURAL; 2.7A {Yersinia pestis} Probab=96.81 E-value=3.3e-06 Score=84.46 Aligned_cols=207 Identities=11% Similarity=0.100 Sum_probs=115.7 Template_Neff=11.800 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .+++.+||++.|.++... ...+...+..+++.++++.+ +++ .+.+.. +. +...+.++ T Consensus 3 ~~~~~~I~~i~~~~~~~~--------~~~~~~~~~~~~~~~~~~~g--------~~~--~~~~~~-~~----~~~~~~~~ 59 (294) T 3QK7_C 3 LGRTDAIALAYPSRPRVL--------NNSTFLEMISWIGIELGKRG--------LDL--LLIPDE-PG----EKYQSLIH 59 (294) T ss_dssp --CCCEEEEEEESSSGGG--------CCHHHHHHHHHHHHHHHTTT--------CEE--EEEEEC-TT----CCCHHHHH T ss_pred CCCCCeEEEEecCCchhh--------cCHHHHHHHHHHHHHHHHcC--------CeE--EEEeCC-Ch----hHHHHHHH Confidence 356789999998643100 01244566677777666542 333 333322 21 12223333 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) ++.. .++|++|....+... .....+...++|+|..+...+ .+.++.+.++... T Consensus 60 ~~~~-------------------~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 112 (294) T 3QK7_C 60 LVET-------------------RRVDALIVAHTQPED-FRLQYLQKQNFPFLALGRSHL-------PKPYAWFDFDNHA 112 (294) T ss_dssp HHHT-------------------TCCSEEEECSCCSSC-HHHHHHHHTTCCEEEESCCCC-------SSCCEEEEECHHH T ss_pred HHHh-------------------CCCCEEEEeCCCCCc-HHHHHHHHCCCCEEEECCCCC-------CCCCeEEEeChHH Confidence 3322 478888865444333 344556668999998775432 1345667777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .++.+++++.+.+.++++++..+. .....+.+++++.+++. ++.+..........+..+....++++++ ..++|+| T Consensus 113 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~i 191 (294) T 3QK7_C 113 GASLAVKRLLELGHQRIAFVSTDARISYVDQRLQGYVQTMSEA-GLMPLAGYLQKADPTRPGGYLAASRLLALEVPPTAI 191 (294) T ss_dssp HHHHHHHHHHHTTCCSEEEEEECSCSHHHHHHHHHHHHHHHHT-TCCCCTTCEEEECSSHHHHHHHHHHHHTSSSCCSEE T ss_pred HHHHHHHHHHHCCCCeEEEEeCCCCCcHHHHHHHHHHHHHHHC-CCCCcccceecCCCCchHHHHHHHHHHcCCCCCCEE Confidence 788888888767888999988532 34556777888887765 3433211111100111223344555542 1357777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 192 ~~~~-~~~a~~~~~~l~~~g~~ 212 (294) T 3QK7_C 192 ITDC-NMLGDGVASALDKAGLL 212 (294) T ss_dssp EESS-HHHHHHHHHHHHHHTCB T ss_pred EECC-cHHHHHHHHHHHHcCCC Confidence 7654 44566778888877763 No 269 >3E3M_D Transcriptional regulator, LacI family; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Plasmid; 1.6A {Silicibacter pomeroyi} Probab=96.81 E-value=3.3e-06 Score=87.29 Aligned_cols=204 Identities=13% Similarity=0.136 Sum_probs=115.2 Template_Neff=11.300 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||+++|..+. .++.....+++.++++.+ + ++.+.+...++ +...+.++ T Consensus 67 ~~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~ 120 (355) T 3E3M_D 67 TKRSGFVGLLLPSLNN------------LHFAQTAQSLTDVLEQGG--------L--QLLLGYTAYSP----EREEQLVE 120 (355) T ss_dssp ----CEEEEEESCSBC------------HHHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEecCCCC------------hhHHHHHHHHHHHHHHCC--------C--EEEEEeCCCCh----HHHHHHHH Confidence 3567899999986532 245566777777665542 2 33344443332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+.... ........+.+.++|+|..+...+ .+..+++..++.. T Consensus 121 ~~~~-------------------~~~d~ii~~~~~-~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 173 (355) T 3E3M_D 121 TMLR-------------------RRPEAMVLSYDG-HTEQTIRLLQRASIPIVEIWEKPA-------HPIGHTVGFSNER 173 (355) T ss_dssp HHHH-------------------TCCSEEEEECSC-CCHHHHHHHHTSCSCEEEESSCCS-------SCSSEEEECCHHH T ss_pred HHHH-------------------hCCCEEEEcCCC-CCHHHHHHHHHCCCCEEEEcCCCC-------CCCCcEEEeCHHH Confidence 3332 478888874322 233445566678999998875432 1345566777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN---YGESGVEAFTQISREIGGVCIAQSQKIP-REPRPGEFEKIIKRLLE-TPNAR 276 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~-~~~~~~~~~~~~~~l~~-~~~~~ 276 (908) .+..+++++.+.+.++|+++..... ....+.++|++.+++. ++.+....... ...+..+....+++++. ..++| T Consensus 174 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d 252 (355) T 3E3M_D 174 AAYDMTNALLARGFRKIVFLGEKDDDWTRGAARRAGFKRAMREA-GLNPDQEIRLGAPPLSIEDGVAAAELILQEYPDTD 252 (355) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESSCTTSHHHHHHHHHHHHHHHT-TSCSCCEEEESCSSCCHHHHHHHHHHHHHHCTTCC T ss_pred HHHHHHHHHHHCCCCeEEEEcCCCCCchhHHHHHHHHHHHHHHC-CCCCCcceecCCCCCCHHHHHHHHHHHHHHCCCCc Confidence 7778888876667889999875432 2456777888887765 34322111100 00111223344555442 13578 Q NP_000836.2 277 AVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 277 viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +|++.. +..+..+++++++.|+. T Consensus 253 ai~~~~-~~~a~~~~~al~~~g~~ 275 (355) T 3E3M_D 253 CIFCVS-DMPAFGLLSRLKSIGVA 275 (355) T ss_dssp EEEESS-HHHHHHHHHHHHHHTCC T ss_pred EEEECC-cHHHHHHHHHHHHcCCC Confidence 787764 44566788888888763 No 270 >2WRZ_A L-ARABINOSE-BINDING PERIPLASMIC PROTEIN; SUGAR TRANSPORT, ARABINOSE BINDING PROTEIN; 2.2A {ESCHERICHIA COLI} Probab=96.80 E-value=3.5e-06 Score=84.89 Aligned_cols=206 Identities=12% Similarity=0.097 Sum_probs=109.7 Template_Neff=11.900 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) +++||++.|..+. .++..+..+++.++++.| +++.+.+. .+. +...+.+++++ T Consensus 2 ~~~I~~i~~~~~~------------~~~~~~~~~~~~~~~~~~----------~~l~~~~~-~~~----~~~~~~~~~l~ 54 (306) T 2WRZ_A 2 NLKLGFLVAQPEE------------PASQTQWKFADKAGKDLG----------FEVIKIAV-PDG----EKTLNAIDSLA 54 (306) T ss_dssp CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHHT----------CEEEEEEC-SSH----HHHHHHHHHHH T ss_pred CeEEEEEeCCCCC------------hHHHHHHHHHHHHHHHhC----------CEEEEEeC-CCH----HHHHHHHHHHH Confidence 5789999987542 245667788888887753 23333343 221 22333444433 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGV-IGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 203 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~v-Ig~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~ 203 (908) . .+++++ +++..+.........+...++|+|..+...+.... ...++++++.+++...+ T Consensus 55 ~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~-~~~~~~~~v~~d~~~~~ 114 (306) T 2WRZ_A 55 A-------------------SGAKGFVISTPDPKLGSAIVAKARGYDMKVIAVDNQFVNAKG-KPMDTVPLVMEAATKIG 114 (306) T ss_dssp H-------------------HTCCEEEEECSCGGGHHHHHHHHHHTTCEEEEESSCCBCTTS-CBCCSSCEEECCHHHHH T ss_pred H-------------------CCCCEEEEeCCCcchhHHHHHHHHhCCCEEEEEcCcccCCCC-CCcccccEEecchHHHH Confidence 2 467774 44444433334455566789999988764432110 01234666777776667 Q NP_000836.2 204 QAMVDIVTA----LGWN--YVSTLAS---EGNYGESGVEAFTQISREIG--GVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 204 ~~~~~~l~~----~~~~--~v~ii~~---~~~~~~~~~~~~~~~~~~~~--~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +.+++++.+ .+++ ++.++.. +..++..+.+++++.+++.+ ...+....... .+..+....++++++ T Consensus 115 ~~~~~~l~~~~~~~g~~~~~i~v~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~--~~~~~~~~~~~~~l~- 191 (306) T 2WRZ_A 115 ERQGQELYKEMQKRGWDVKESAVMAITANELDTARRRTTGSMDALKAAGFPEKQIYQVPTKS--EDIPGAFDAANSMLV- 191 (306) T ss_dssp HHHHHHHHHHHHHHTCCGGGEEEEEEECTTSHHHHHHHHHHHHHHHHTTCCGGGEEEEECSS--SSHHHHHHHHHHHHH- T ss_pred HHHHHHHHHHHHHcCCCccceEEEEEEcCCChhhHHHHHHHHHHHHHcCCCCceeEEecCCC--CChhHHHHHHHHHHH- Confidence 777766533 4555 6665542 22345567778888777642 01221111100 111233445555543 Q NP_000836.2 273 PNARA---VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 273 ~~~~v---iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .+++. ++++.++..+..+++++++.|+. T Consensus 192 ~~~~~~~~~i~~~~~~~a~~~~~~l~~~g~~ 222 (306) T 2WRZ_A 192 QHPEVKHWLIVGMNDSTVLGGVRATEGQGFK 222 (306) T ss_dssp TCTTCSEEEEECSSHHHHHHHHHHHHHTTCC T ss_pred hCCCCceEEEEecChHHHHHHHHHHHhCCCC Confidence 23332 23333344566788888887764 No 271 >5BQ3_A Rhamnose ABC transporter, rhamnose-binding protein; ABC transporter, Structural Genomics, Joint; HET: MSE; 2.6A {Actinomyces odontolyticus ATCC 17982} Probab=96.78 E-value=3.7e-06 Score=85.92 Aligned_cols=218 Identities=11% Similarity=0.032 Sum_probs=115.3 Template_Neff=11.600 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI-TLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~-~l~~~~~d~~~~~~~a~~~~~ 117 (908) .....+.++||++.|..+. .++.....+++.++++.+ + ++.+.. ++..++ .... T Consensus 21 ~~~~~~~~~Igv~~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~~~~~-~~~~~~----~~~~ 75 (332) T 5BQ3_A 21 GSYDVSSQSITFIPKQLNN------------PFSDVMLGGGKNAAGEIG--------FAEVNVVG-PLEASS----SSQV 75 (332) T ss_dssp CCCCCSSCEEEEECSSSSC------------HHHHHHHHHHHHHHHHHT--------CSEEEECC-CSSCCT----TTTH T ss_pred CcccCCCcEEEEEeCCCCC------------HHHHHHHHHHHHHHHHhC--------CcEEEEEC-CCCCCH----HHHH Confidence 4556778999999986542 245667778888887753 3 344433 332222 2223 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVI-GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vI-g~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. ++++++| ++..+.........+...++|+|..+...+. .....+... T Consensus 76 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~v~~ 131 (332) T 5BQ3_A 76 SFINSEVQ-------------------AGTNVLVIAANDPDAVCPALQDARKAGTKVVTFDSDSAA-----DCRDLFINQ 131 (332) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSSTTTSHHHHHHHHHHTCEEEEESSCCCT-----TSCSEEEES T ss_pred HHHHHHHH-------------------hCCCEEEEeCCCHHhhHHHHHHHHHcCCEEEEECCCCCc-----cccceeEec Confidence 33444332 4678744 4443333334445566789999987765431 011222222 Q NP_000836.2 197 PPDSYQAQAMVDIVTAL--GWNYVSTLAS--EGNYGESGVEAFTQISRE---IGGVCIAQSQKIPREPRPGEFEKIIKRL 269 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~--~~~~v~ii~~--~~~~~~~~~~~~~~~~~~---~~~i~v~~~~~~~~~~~~~~~~~~~~~l 269 (908) .+....++.+++++.+. +.++++++.. +..+...+.+.+++.+++ ..++++....... .+..+....++++ T Consensus 132 ~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~ 209 (332) T 5BQ3_A 132 VESKQVAITMLDMVSDQIGGSGKVAILSATANAANQNAWIKFMEDEIASNDKYKGIEIVAKVYGD--DDDTKSFQEAQGL 209 (332) T ss_dssp SCHHHHHHHHHHHHHHHHTSCEEEEEEESCTTCHHHHHHHHHHHHHHHHCTTSTTEEEEEEEECT--TCHHHHHHHHHHH T ss_pred cCHHHHHHHHHHHHHHHhCCCeEEEEEECCCCCHHHHHHHHHHHHHHHhchhcCCeEEEEEEeCC--CCHHHHHHHHHHH Confidence 44555566777776554 5678999985 333455666777766642 1123332111111 1112233445555 Q NP_000836.2 270 LET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 270 ~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++. .+.++|+... +..+..+++++++.|+..++.+++. T Consensus 210 l~~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~~~v~vi~~ 248 (332) T 5BQ3_A 210 LQAHPDLNAIVSPT-TVGIAATARYLSTSDYKGKVFLTGL 248 (332) T ss_dssp HHHCTTCCEEEECS-HHHHHHHHHHHHHSTTTTTSEEEEB T ss_pred HHHCCCcCEEEeCC-cchHHHHHHHHhhcCCCCcEEEEEe Confidence 421 2455665543 4445567778877776323444443 No 272 >4RY0_A Probable ribose ABC transporter, substrate-binding; SUGAR TRANSPORTER, ENZYME FUNCTION INITIATIVE; HET: RIP; 1.4A {Rhizobium etli CFN 42} Probab=96.77 E-value=3.9e-06 Score=83.60 Aligned_cols=211 Identities=9% Similarity=0.047 Sum_probs=113.7 Template_Neff=12.000 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +..+||++.|..+. .++.....+++.++++.+ +++.+.++..++. ...+.++++ T Consensus 2 ~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~g----------~~~~~~~~~~~~~----~~~~~~~~l 55 (289) T 4RY0_A 2 MADLIAIITPAHDN------------PFFKAEAVGAEAKAKELG----------YETLVMTHDDDAN----KQSEMIDTA 55 (289) T ss_dssp CCCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCHH----HHHHHHHHH T ss_pred ccceEEEEecCCCC------------HHHHHHHHHHHHHHHHhC----------CEEEEEcCCCCHH----HHHHHHHHH Confidence 46789999987542 255667778887777642 3344444433321 222333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAA-ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~-~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. ++++++|... ...........+.+.++|+|..+...+. ..++++++.+++... T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~ 111 (289) T 4RY0_A 56 IG-------------------RGAKAIILDNAGADASVAAVKKAKDAGIPSFLIDREINA-----TGVAVAQIVSNNYQG 111 (289) T ss_dssp HH-------------------TTCSEEEECCSCTTTHHHHHHHHHHTTCCEEEESSCCSC-----SSSSSEEEEECHHHH T ss_pred Hh-------------------cCCCEEEEeCCChhhhHHHHHHHHHCCCCEEEeCCCCCC-----CCCceEEEEcCcHHH Confidence 32 4677665433 2222223345566789999987654331 123456677777777 Q NP_000836.2 203 AQAMVDIVTALGWN--YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 203 ~~~~~~~l~~~~~~--~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ++.+++++.+.+.+ +++++.. +..+...+.++|++.+++.+...+....... .+..+....+++++. ..++|+ T Consensus 112 ~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~~~d~ 189 (289) T 4RY0_A 112 AQLGAQEFVKLMGEKGNYVELVGKESDTNAGIRSQGYHDVIDDYPEMKSVAKQSAN--WSQTEAYSKMETILQANPDIKG 189 (289) T ss_dssp HHHHHHHHHHHHTTCEEEEEEECCTTSHHHHHHHHHHHHHHTTCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCTTCCE T ss_pred HHHHHHHHHHHhCCCccEEEEEcCCCChhHHHHHHHHHHHHHHCCCeEEEEeeeCC--CCHHHHHHHHHHHHHHCCCCCE Confidence 77888877654433 3555543 2334556777888877664212221111000 111223344555542 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) |++.. +..+..+++++++.|.. ++.+++. T Consensus 190 i~~~~-~~~a~~~~~a~~~~~~~-~~~ii~~ 218 (289) T 4RY0_A 190 VISGN-DTMAMGAIAALQAAGRK-DVIVVGF 218 (289) T ss_dssp EEESS-HHHHHHHHHHHHHTTCT-TSEEECS T ss_pred EEECC-hHHHHHHHHHHHHCCCC-CeEEEEe Confidence 76664 44566777888777662 3344443 No 273 >3TB6_A Arabinose metabolism transcriptional repressor; transcription regulation, arabinose binding, DNA; HET: ARB, GOL; 2.21A {Bacillus subtilis} Probab=96.75 E-value=4.4e-06 Score=83.69 Aligned_cols=206 Identities=12% Similarity=0.113 Sum_probs=114.5 Template_Neff=12.000 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+..+||++.|..+. .++..+..+++.++++.| +++.+.+...++ +...+.+ T Consensus 11 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~~----------~~~~~~~~~~~~----~~~~~~~ 64 (298) T 3TB6_A 11 ALHSNKTIGVLTTYISD------------YIFPSIIRGIESYLSEQG----------YSMLLTSTNNNP----DNERRGL 64 (298) T ss_dssp ----CCEEEEEESCSSS------------TTHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred hccCCCeEEEEecCCcc------------hhHHHHHHHHHHHHHHcC----------CcEEEEecCCCH----HHHHHHH Confidence 45568899999997542 256677888888887753 233444443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI----MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~----~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) ++++. ++++++|+...+.... .....+...++|+|..+...+ .+..+++. T Consensus 65 ~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~~~~ip~v~~~~~~~-------~~~~~~v~ 118 (298) T 3TB6_A 65 ENLLS-------------------QHIDGLIVEPTKSALQTPNIGYYLNLEKNGIPFAMINASYA-------ELAAPSFT 118 (298) T ss_dssp HHHHH-------------------TCCSEEEECCSSTTSCCTTHHHHHHHHHTTCCEEEESSCCT-------TCSSCEEE T ss_pred HHHHh-------------------CCCCEEEEecCCcccCCCChHHHHHHHHcCCCEEEEecCCC-------CCCCCEEE Confidence 44332 4788888654433211 222355678999998776443 13456667 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWNYVSTLAS-EGNYGESGVEAFTQISREIGGVCIAQS--QKIPREPRPGEFEKIIKRLLE-- 271 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~~v~ii~~-~~~~~~~~~~~~~~~~~~~~~i~v~~~--~~~~~~~~~~~~~~~~~~l~~-- 271 (908) .+....++.+++++.+.+.++++++.. ++..+..+.++|++.+++. ++..... .......+..+..+.++++++ T Consensus 119 ~d~~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 197 (298) T 3TB6_A 119 LDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKRMNGFIQAHRER-ELFPSPDMIVTFTTEEKESKLLEKVKATLEKN 197 (298) T ss_dssp ECHHHHHHHHHHHHHHTTCCSEEEEEESSSHHHHHHHHHHHHHHHHT-TCCCCGGGEEEECHHHHTTHHHHHHHHHHHHT T ss_pred eCHHHHHHHHHHHHHHCCCCeEEEEEcCCCccchHHHHHHHHHHHhC-CCCCChhhEEEecchHHHHHHHHHHHHHHHHc Confidence 777777778888876667888888874 3345566777888877764 2322111 001100111111222333321 Q NP_000836.2 272 -TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 -~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 198 ~~~~~~~i~~~~-~~~a~~~~~~l~~~g~~ 226 (298) T 3TB6_A 198 SKHMPTAILCYN-DEIALKVIDMLREMDLK 226 (298) T ss_dssp TTSCCSEEECSS-HHHHHHHHHHHHHTTCC T ss_pred ccCCCCEEEEcC-hHHHHHHHHHHHHCCCC Confidence 12478887764 44566778888877763 No 274 >3GYB_A Transcriptional regulators (LACI-FAMILY TRANSCRIPTIONAL REGULATORY; Transcription, Protein Structure Initiative II(PSI; 1.6A {Corynebacterium glutamicum} Probab=96.70 E-value=5.4e-06 Score=82.18 Aligned_cols=198 Identities=14% Similarity=0.080 Sum_probs=111.6 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|..+. .++..+..+++.++++. |+++ .+.+...+ . ...+.+++ T Consensus 3 ~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~--~~~~~~~~-~----~~~~~~~~ 55 (280) T 3GYB_A 3 LRTQLIAVLIDDYSN------------PWFIDLIQSLSDVLTPK--------GYRL--SVIDSLTS-Q----AGTDPITS 55 (280) T ss_dssp -CCCEEEEEESCTTS------------GGGHHHHHHHHHHHGGG--------TCEE--EEECSSSS-C----SSSCHHHH T ss_pred CCCcEEEEEecCCCC------------hHHHHHHHHHHHHHHHh--------CcEE--EEEecCCC-c----ccchHHHH Confidence 457899999987542 25566777888777664 2333 33333222 1 12223333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. +++|++|+....... .+...++|++..+...+. .+..+.+.+++... T Consensus 56 ~~~-------------------~~~d~ii~~~~~~~~-----~~~~~~~pvv~~~~~~~~------~~~~~~v~~d~~~~ 105 (280) T 3GYB_A 56 ALS-------------------MRPDGIIIAQDIPDF-----TVPDSLPPFVIAGTRITQ------ASTHDSVANDDFRG 105 (280) T ss_dssp HHT-------------------TCCSEEEEESCC-------------CCCEEEESCCCSS------SCSTTEEEECHHHH T ss_pred HHh-------------------cCCCEEEEeCCCCCC-----CCcccCCCEEEeCCCCCC------CCCCcEEEeChHHH Confidence 332 478888875433321 134568998876653321 13456677777777 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~ 281 (908) ++.+++++.+.+.++++++..+......+.++|.+.+++. ++.+....... ..+..+....+++++.. .++++|++. T Consensus 106 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~l~~~~~~~~i~~~ 183 (280) T 3GYB_A 106 AEIATKHLIDLGHTHIAHLRVGSGAGLRRFESFEATMRAH-GLEPLSNDYLG-PAVEHAGYTETLALLKEHPEVTAIFSS 183 (280) T ss_dssp HHHHHHHHHHTTCCSEEEECCSSHHHHHHHHHHHHHHHHT-TCCCEECCCCS-CCCHHHHHHHHHHHHHHCTTCCEEEES T ss_pred HHHHHHHHHHCCCCeEEEEeCCCcchHHHHHHHHHHHHHC-CCCCCcccccC-CcccchHHHHHHHHHHhCCCCCEEEEC Confidence 8888888876677899998865556667778888887765 34433221111 01112233444455421 246777766 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~ 300 (908) . +..+..+++++++.|+. T Consensus 184 ~-~~~a~~~~~~~~~~g~~ 201 (280) T 3GYB_A 184 N-DITAIGALGAARELGLR 201 (280) T ss_dssp S-HHHHHHHHHHHHHHTCC T ss_pred C-HHHHHHHHHHHHHcCCC Confidence 4 34566778888877764 No 275 >3GYB_B Transcriptional regulators (LACI-FAMILY TRANSCRIPTIONAL REGULATORY; Transcription, Protein Structure Initiative II(PSI; HET: MSE; 1.6A {Corynebacterium glutamicum} Probab=96.70 E-value=5.4e-06 Score=82.18 Aligned_cols=198 Identities=14% Similarity=0.080 Sum_probs=106.1 Template_Neff=11.800 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) +++++||++.|..+. .++..+..+++.++++. |+++ .+.+...+ . ...+.+++ T Consensus 3 ~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~--~~~~~~~~-~----~~~~~~~~ 55 (280) T 3GYB_B 3 LRTQLIAVLIDDYSN------------PWFIDLIQSLSDVLTPK--------GYRL--SVIDSLTS-Q----AGTDPITS 55 (280) T ss_dssp --CCEEEEEESCTTS------------GGGHHHHHHHHHHHGGG--------TCEE--EEECSSSS-C----SSSCHHHH T ss_pred CCCcEEEEEecCCCC------------hHHHHHHHHHHHHHHHh--------CcEE--EEEecCCC-c----ccchHHHH Confidence 457899999987542 25566777888777664 2333 33333222 1 12223333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. +++|++|+....... .+...++|++..+...+. .+..+.+.+++... T Consensus 56 ~~~-------------------~~~d~ii~~~~~~~~-----~~~~~~~pvv~~~~~~~~------~~~~~~v~~d~~~~ 105 (280) T 3GYB_B 56 ALS-------------------MRPDGIIIAQDIPDF-----TVPDSLPPFVIAGTRITQ------ASTHDSVANDDFRG 105 (280) T ss_dssp HHT-------------------TCCSEEEEECSSSSS-----CCCBCCC---------------------CCCEECHHHH T ss_pred HHh-------------------cCCCEEEEeCCCCCC-----CCcccCCCEEEeCCCCCC------CCCCcEEEeChHHH Confidence 332 478888875433321 134568998876653321 13456677777777 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMF 281 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~ 281 (908) ++.+++++.+.+.++++++..+......+.++|.+.+++. ++.+....... ..+..+....+++++.. .++++|++. T Consensus 106 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~~-~~~~~~~~~~~~~~l~~~~~~~~i~~~ 183 (280) T 3GYB_B 106 AEIATKHLIDLGHTHIAHLRVGSGAGLRRFESFEATMRAH-GLEPLSNDYLG-PAVEHAGYTETLALLKEHPEVTAIFSS 183 (280) T ss_dssp HHHHHHHHHHTTCCSEEEECCSSHHHHHHHHHHHHHHHHT-TCCCEECCCCS-CCCHHHHHHHHHHHHHHCTTCCEEEES T ss_pred HHHHHHHHHHCCCCeEEEEeCCCcchHHHHHHHHHHHHHC-CCCCCcccccC-CcccchHHHHHHHHHHhCCCCCEEEEC Confidence 8888888876677899998865556667778888887765 34433221111 01112233444455421 246777766 Q NP_000836.2 282 ANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 282 ~~~~~~~~~l~~~~~~g~~ 300 (908) . +..+..+++++++.|+. T Consensus 184 ~-~~~a~~~~~~~~~~g~~ 201 (280) T 3GYB_B 184 N-DITAIGALGAARELGLR 201 (280) T ss_dssp S-HHHHHHHHHHHHHHTCC T ss_pred C-HHHHHHHHHHHHHcCCC Confidence 4 34566778888877764 No 276 >5UFH_A LacI-type transcriptional regulator; Human Microbiome, structural genomics, PSI-Biology; HET: NO3, MSE; 1.45A {Bifidobacterium animalis subsp. lactis (strain AD011)} Probab=96.67 E-value=5.9e-06 Score=85.04 Aligned_cols=202 Identities=10% Similarity=0.039 Sum_probs=112.8 Template_Neff=11.300 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ....+||++.|..+. .++..+..+++.++++.+ +.+. +.+...++ ....+.++. T Consensus 63 ~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~--~~~~~~~~----~~~~~~~~~ 116 (347) T 5UFH_A 63 GTTGLLGLAIFDFSQ------------PFASYLADQIIVCAREHH--------YGVI--INTYGQNE----HGLARAMRQ 116 (347) T ss_dssp ---CEEEEEESCSSS------------HHHHHHHHHHHHHHHHTT--------CEEE--EEECTTST----THHHHHHHH T ss_pred CCCCeEEEEEcCCCC------------hhHHHHHHHHHHHHHHCC--------CEEE--EEcCCCCh----HHHHHHHHH Confidence 467889999986432 245567777777776642 2333 33332221 122233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|+...... .....+...++|+|..+...+ ......+..++... T Consensus 117 ~~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~ 168 (347) T 5UFH_A 117 ANN-------------------LAADGWIVFADHAM--GQHSKMLDQSYPLVLTGDWDA-------YGKVDQVTMPNVEA 168 (347) T ss_dssp GGG-------------------SSCSEEEEECCSCC--CC--CTTCCSSCEEEESSSCC-------TTSSEEEECCHHHH T ss_pred HHh-------------------cCCCEEEEEccccc--chhHHHHhcCCCEEEeCCccc-------CCCCcEEEcCHHHH Confidence 332 47888876544322 223445567999997765432 13455666777777 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEGN------------YGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKRL 269 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~~------------~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~l 269 (908) ++.+++++.+.+.++++++..+.. +...+.++|++.+++. ++.+.....+... .+..+....++++ T Consensus 169 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~ 247 (347) T 5UFH_A 169 MRYTTNRLLDSGYRSIALFGADGSLGARHYRQATEGTQELRVQGYMQAYEEH-GIEARMDMLFSGGLLTSDSGVRATNLM 247 (347) T ss_dssp HHHHHHHHHHTTCCCEEEESSCGGGCHHHHHHCCSCHHHHHHHHHHHHHHHT-TCCCCGGGEECCSSSSHHHHHHHHHHH T ss_pred HHHHHHHHHHcCCCeEEEEcCCcccchhhhhccCcccHHHHHHHHHHHHHHC-CCCCCHHHeecCCCCChHHHHHHHHHH Confidence 888888886678889999985432 4456778888888775 3443221111100 1111223344444 Q NP_000836.2 270 LE-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 270 ~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +. ..++|+|++.. +..+..+++++++.|+. T Consensus 248 ~~~~~~~~ai~~~~-d~~a~~~~~~l~~~g~~ 278 (347) T 5UFH_A 248 MDQGVRPDAIICLN-DAMALGALHQLQVRGIR 278 (347) T ss_dssp HHTTCCCSEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHcCCCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 32 13678887764 44567778888887764 No 277 >3CTP_A Periplasmic binding protein/LacI transcriptional regulator; STRUCTURAL GENOMICS, PROTEIN STRUCTURE INITIATIVE; HET: XLF; 1.41A {Alkaliphilus metalliredigens} Probab=96.67 E-value=6e-06 Score=84.26 Aligned_cols=198 Identities=13% Similarity=0.148 Sum_probs=114.7 Template_Neff=11.500 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .++..+..+++.++++.+ +++.+.+...+. ....+.++ T Consensus 57 ~~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 110 (330) T 3CTP_A 57 TKNSKTIGLMVPNISN------------PFFNQMASVIEEYAKNKG----------YTLFLCNTDDDK----EKEKTYLE 110 (330) T ss_dssp ---CCEEEEEESCTTS------------HHHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC----------CEEEEEeCCCCH----HHHHHHHH Confidence 3567899999986432 245567777777776642 234444543332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.. ..+...++|+|..+...+ +..+++..++.. T Consensus 111 ~~~~-------------------~~~d~ii~~~~~~~-----~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 158 (330) T 3CTP_A 111 VLQS-------------------HRVAGIIASRSQCE-----DEYANIDIPVVAFENHIL--------DNIITISSDNYN 158 (330) T ss_dssp HHHH-------------------TTCSEEEEETCCCS-----GGGTTCCSCEEEESSCCC--------TTSCEEEECHHH T ss_pred HHHH-------------------CCCCEEEEeCCCCh-----HHHhcCCCCEEEEcCCCc--------cCCcEEEcCcHH Confidence 3332 47888886543322 235667999998765432 245667777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVI 279 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv 279 (908) .+..+++++.+.++++++++..+. .+...+.+++++.+++. ++.+.... ...+.+..+....++.+....++|+|+ T Consensus 159 ~g~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~i~ 236 (330) T 3CTP_A 159 GGRMAFDHLYEKGCRKILHIKGPEVFEATELRYKGFLDGARAK-DLEIDFIE-FQHDFQVKMLEEDINSMKDIVNYDGIF 236 (330) T ss_dssp HHHHHHHHHHHTTCCSEEEEECCTTCHHHHHHHHHHHHHHHHT-TCCCEEEE-CSSSCCGGGGGCCCTTGGGGGGSSEEE T ss_pred HHHHHHHHHHHcCCCcEEEEeCCccchhHHHHHHHHHHHHHHC-CCCCCeEE-ecccccHHHHHHHHHHhhhcCCCCEEE Confidence 788888888777888999988543 35566778888887764 34432211 110011122333444443223578777 Q NP_000836.2 280 MFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 280 ~~~~~~~~~~~l~~~~~~g~~ 300 (908) +.. +..+..+++++++.|+. T Consensus 237 ~~~-~~~a~~~~~al~~~g~~ 256 (330) T 3CTP_A 237 VFN-DIAAATVMRALKKRGVS 256 (330) T ss_dssp ESS-HHHHHHHHHHHHHTTCC T ss_pred EcC-HHHHHHHHHHHHHCCCC Confidence 764 44566778888887763 No 278 >3G85_A Transcriptional regulator (LacI family); Transcription regulator, PSI-II, 11230o, Structural; 1.84A {Clostridium acetobutylicum ATCC 824} Probab=96.67 E-value=6e-06 Score=82.30 Aligned_cols=204 Identities=12% Similarity=0.083 Sum_probs=115.0 Template_Neff=11.700 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ..++..+||++.|.... ..++.....+++.++++.+ +.+++.+.+...+... ... T Consensus 7 ~~~~~~~I~~i~~~~~~-----------~~~~~~~~~g~~~a~~~~g--------~~~~~~~~~~~~~~~~----~~~-- 61 (289) T 3G85_A 7 NSQSKPTIALYWSSDIS-----------VNIISRFLRGLQSKLAKQN--------YNYNVVICPYKTDCLH----LEK-- 61 (289) T ss_dssp ----CCEEEEEEETTSC-----------GGGHHHHHHHHHHHHHHTT--------TCSEEEEEEECTTCGG----GCG-- T ss_pred cCCCCCeEEEEeCCCCC-----------cHHHHHHHHHHHHHHHHcC--------CCcEEEEEEcCCChHH----Hhh-- Confidence 45578999999983211 1356677888888887752 2345555554433211 111 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) +.+.. .++|++|+...+......... ...++|+|..+... +.+..+..++. T Consensus 62 ~~~~~-------------------~~~d~ii~~~~~~~~~~~~~~-~~~~ipvv~~~~~~---------~~~~~v~~d~~ 112 (289) T 3G85_A 62 GISKE-------------------NSFDAAIIANISNYDLEYLNK-ASLTLPIILFNRLS---------NKYSSVNVDNY 112 (289) T ss_dssp GGSTT-------------------TCCSEEEESSCCHHHHHHHHH-CCCSSCEEEESCCC---------SSSEEEEECHH T ss_pred chhhh-------------------cCCCEEEEecCCcccHHHHHH-hCCCCCEEEeCCCc---------cCCCEEEeCcH Confidence 01111 578888865443322223333 46789999877532 23456667777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+.+.++++++..+. .....+.++|++.+++. ++.+..........+..+..+.+++++. ..++++ T Consensus 113 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ 191 (289) T 3G85_A 113 KMGEKASLLFAKKRYKSAAAILTESLNDAMDNRNKGFIETCHKN-GIKISENHIIAAENSIHGGVDAAKKLMKLKNTPKA 191 (289) T ss_dssp HHHHHHHHHHHHTTCCBCEEEECCCSSHHHHHHHHHHHHHHHHT-TCBCCGGGEEECCSSHHHHHHHHHHHTTSSSCCSE T ss_pred HHHHHHHHHHHHcCCCeeEEEecCCCChHHHHHHHHHHHHHHHc-CCCCCccceEEcCCChHHHHHHHHHHHhcCCCCCE Confidence 7788888888777888998887432 34566778888888765 3443321111100111223344455432 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 192 i~~~~-~~~a~~~~~~l~~~g~~ 213 (289) T 3G85_A 192 LFCNS-DSIALGVISVLNKRQIS 213 (289) T ss_dssp EEESS-HHHHHHHHHHHHHTTCC T ss_pred EEECC-HHHHHHHHHHHHHCCCC Confidence 77664 44566778888877764 No 279 >3H5O_B Transcriptional regulator GntR; 11234b, transcription regulator, GntR, Chromobacterium; HET: MSE, SO4; 2.3A {Chromobacterium violaceum} Probab=96.67 E-value=6.1e-06 Score=84.58 Aligned_cols=203 Identities=14% Similarity=0.107 Sum_probs=113.6 Template_Neff=11.300 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|..+. .++.....+++.++++.+ +++.+.|+..++ +...+.++ T Consensus 59 ~~~~~~I~~v~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~~ 112 (339) T 3H5O_B 59 SAKSRTVLVLIPSLAN------------TVFLETLTGIETVLDAAG----------YQMLIGNSHYDA----GQELQLLR 112 (339) T ss_dssp ----CEEEEEESCSTT------------CTTHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHHH T ss_pred cCCCCEEEEEEcCCCC------------hhHHHHHHHHHHHHHHcC----------CeEEEEeCCCCh----hHHHHHHH Confidence 3567899999986542 245567778877776643 233444543332 22233344 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. .++|++|+...+.. ......+...++|+|..+...+ +.++.+..++.. T Consensus 113 ~l~~-------------------~~~d~ii~~~~~~~-~~~~~~~~~~~ipvv~~~~~~~--------~~~~~v~~d~~~ 164 (339) T 3H5O_B 113 AYLQ-------------------HRPDGVLITGLSHA-EPFERILSQHALPVVYMMDLAD--------DGRCCVGFSQED 164 (339) T ss_dssp HHHT-------------------TCCSEEEEESSCCC-TTHHHHHHHTTCCEEEEESCCS--------SSCCEEECCHHH T ss_pred HHHh-------------------cCCCEEEEeCCCCC-hHHHHHHHhCCCCEEEEccCCC--------CCCcEEEcCHHH Confidence 4332 46888886543332 3344556678999998764321 345566677777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASE-GNYGESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~-~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .++.+++++.+.+.++++++... +.....+.++|++.+++. +..+........ ..+.......+++++. ..++|+| T Consensus 165 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~r~~~~~~~l~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~d~I 243 (339) T 3H5O_B 165 AGAAITRHLLSRGKRRIGFLGAQLDERVMKRLDGYRAALDAA-DCRDAGLEWLDPQPSSMQMGADMLDRALAERPDCDAL 243 (339) T ss_dssp HHHHHHHHHHHTTCCSEEEEEESCCHHHHHHHHHHHHHHHHH-TCCCGGGEEEECSCCCHHHHHHHHHHHHHHCTTCCEE T ss_pred HHHHHHHHHHHCCCCcEEEEeCCCCHHHHHHHHHHHHHHHHC-CCcccCCccccCCCCCHHHHHHHHHHHHHhCCCCCEE Confidence 78888888876688899999854 334556777888877764 232211111110 0011112233333332 1356777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 244 ~~~~-~~~a~~~~~~l~~~g~~ 264 (339) T 3H5O_B 244 FCCN-DDLAIGALARSQQLGIA 264 (339) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7664 44566778888877763 No 280 >5YSZ_A Transcriptional regulator, LacI family; transcriptional regulator, cellulase gene regulator; HET: CBI, GOL; 1.631A {Thermobifida fusca YX} Probab=96.62 E-value=7.5e-06 Score=84.75 Aligned_cols=148 Identities=11% Similarity=0.080 Sum_probs=89.0 Template_Neff=11.100 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|+...+... .....+...++|+|..+...+. ..+.++.+..++...+..+++++.+.+.++++++..+ T Consensus 143 ~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~~~~~~~~l~~~g~~~i~~l~~~ 216 (360) T 5YSZ_A 143 QHVDGVLLLSLHRDD-PLPQMLDEAGVPYVYGGRPLGV-----PEEQVSYVDIDNIGGGRQATQRLIETGHRRIATIAGP 216 (360) T ss_dssp SCCSEEEEESCCTTC-SHHHHHHHHTCCEEEESCCTTS-----CGGGCCEEEECHHHHHHHHHHHHHHTTCSSEEEEECC T ss_pred CCCCEEEEECCCCCC-chHHHHHHcCCCEEEeCCCCCC-----CcccCcEEEcCcHHHHHHHHHHHHHcCCCcEEEEeCC Confidence 578888765433332 3445566789999987754321 1245667777777788888888876788899999854 Q NP_000836.2 225 GN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 225 ~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .. +...+.++|++.+++. ++.+........+.+..+....++++++ ..++|+|++.. +..+..+++++++.|.. T Consensus 217 ~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~daI~~~~-d~~a~~~~~al~~~g~~ 293 (360) T 5YSZ_A 217 QDMVAGVERLQGYREALLAA-GMEYDETLVSYGDFTYDSGVAAMRELLDRAPDVDAVFAAS-DLMGLAALRVLRASGRR 293 (360) T ss_dssp TTSHHHHHHHHHHHHHHHHT-TCCCCGGGEEECCSSHHHHHHHHHHHHHHCTTCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred cccHHHHHHHHHHHHHHHHC-CCCCCHhheeecCCCHHHHHHHHHHHHHhCCCCCEEEECC-hHHHHHHHHHHHHcCCC Confidence 33 5566778888887765 3433211111100112233444555542 12477777664 44566778888877763 No 281 >3MIZ_A Putative transcriptional regulator protein, LacI; Lacl family, Protein Structure Initiative; HET: MSE; 1.91A {Rhizobium etli} Probab=96.58 E-value=8.6e-06 Score=81.66 Aligned_cols=206 Identities=13% Similarity=0.104 Sum_probs=115.6 Template_Neff=11.800 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+..+||++.|..... .+...+..+++.++++.+ +++.+.+...++ +...+.+ T Consensus 9 ~~~~~~~I~~v~~~~~~~-----------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~~ 63 (301) T 3MIZ_A 9 RSSRSNTFGIITDYVSTT-----------PYSVDIVRGIQDWANANG----------KTILIANTGGSS----EREVEIW 63 (301) T ss_dssp ---CCCEEEEEESSTTTC-----------CSCHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHHH T ss_pred hcCCCCEEEEEecCCCCC-----------chHHHHHHHHHHHHHHcC----------CeEEEEecCCCH----HHHHHHH Confidence 456789999999854211 245567778777776642 233444443332 2223334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. +++|++|+....... ....+...++|+|..+...+. .+.++.+..++. T Consensus 64 ~~~~~-------------------~~~d~ii~~~~~~~~--~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~d~~ 116 (301) T 3MIZ_A 64 KMFQS-------------------HRIDGVLYVTMYRRI--VDPESGDVSIPTVMINCRPQT------RELLPSIEPDDY 116 (301) T ss_dssp HHHHH-------------------TTCSEEEEEEEEEEE--CCCCCTTCCCCEEEEEEECSS------TTSSCEEEECHH T ss_pred HHHHh-------------------CCCCEEEEecCCccc--CCcccccCCCCEEEEcCCCCC------cccCCcceeChH Confidence 43332 478888865433221 222456789999987764321 234567777777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPR-----EPRPGEFEKIIKRLLET- 272 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~-----~~~~~~~~~~~~~l~~~- 272 (908) ..++.+++++.+.+.++++++..+. .....+.+++++.+++. ++.+.....+.. ..+..+....++++++. T Consensus 117 ~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~ 195 (301) T 3MIZ_A 117 QGARDLTRYLLERGHRRIGYIRLNPILLGAELRLDAFRRTTSEF-GLTENDLSISLGMDGPVGAENNYVFAAATEMLKQD 195 (301) T ss_dssp HHHHHHHHHHHTTTCCSEEEEECCTTSHHHHHHHHHHHHHHHHH-TCCGGGEEEEECEESSTTSCEECHHHHHHHHHTST T ss_pred HHHHHHHHHHHHCCCCcEEEEecCcccccHHHHHHHHHHHHHHc-CCChhhceEEecCCCCCCcccchHHHHHHHHHhcC Confidence 7888888888666788999988533 23456777888887765 344321111100 00111122344554421 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) .++++|++.. +..+..+++++++.|+. T Consensus 196 ~~~~~i~~~~-~~~a~~~~~~l~~~g~~ 222 (301) T 3MIZ_A 196 DRPTAIMSGN-DEMAIQIYIAAMALGLR 222 (301) T ss_dssp TCCSEEEESS-HHHHHHHHHHHHTTTCC T ss_pred CCCCEEEECC-HHHHHHHHHHHHHCCCC Confidence 2477777664 44566777777777763 No 282 >1TJY_A sugar transport protein; PROTEIN-LIGAND COMPLEX, SIGNALING PROTEIN; HET: PAV; 1.3A {Salmonella typhimurium} SCOP: c.93.1.1 Probab=96.56 E-value=9.4e-06 Score=82.17 Aligned_cols=210 Identities=10% Similarity=-0.009 Sum_probs=113.6 Template_Neff=11.200 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDT-CSRDTYALEQSLTFVQA 122 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~-~~~~~~a~~~~~~~~~~ 122 (908) ++++||++.|..+. .++.....+++.++++.+ +++. +.+. ..+. ....+.+++ T Consensus 2 ~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~g--------~~~~--~~~~~~~~~----~~~~~~~~~ 55 (316) T 1TJY_A 2 SAERIAFIPKLVGV------------GFFTSGGNGAQEAGKALG--------IDVT--YDGPTEPSV----SGQVQLVNN 55 (316) T ss_dssp CCCEEEEECSSSSS------------HHHHHHHHHHHHHHHHHT--------CEEE--ECCCSSCCH----HHHHHHHHH T ss_pred CCeEEEEEecCCCC------------HHHHHHHHHHHHHHHHhC--------CEEE--EECCCCCCH----HHHHHHHHH Confidence 46789999987542 255677788888877752 3333 3333 2222 223334444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAAS-SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP-PDS 200 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s-~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~-~~~ 200 (908) ++. .+++++++...+ .........+...++|+|......+. .+..+.+.. ++. T Consensus 56 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~------~~~~~~v~~~d~~ 110 (316) T 1TJY_A 56 FVN-------------------QGYDAIIVSAVSPDGLCPALKRAMQRGVKILTWDSDTKP------ECRSYYINQGTPK 110 (316) T ss_dssp HHH-------------------TTCSEEEECCSSSSTTHHHHHHHHHTTCEEEEESSCCCG------GGCSEEEESCCHH T ss_pred HHH-------------------cCCCEEEEcCCChhhhHHHHHHHHHCCCEEEEECCCCCc------hhceeEEecCCHH Confidence 332 467877764333 22234455667789999987764331 122334444 455 Q NP_000836.2 201 YQAQAMVDIVTAL-G--WNYVSTLAS--EGNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLET-P 273 (908) Q Consensus 201 ~~~~~~~~~l~~~-~--~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~ 273 (908) ..++.+++++.+. + .++|+++.. ++.....+.++|++.+++.. ++.+....... .+..+....+++++.. . T Consensus 111 ~~g~~~~~~l~~~~~~~~~~v~~l~~~~~~~~~~~r~~g~~~~~~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~l~~~~ 188 (316) T 1TJY_A 111 QLGSMLVEMAAHQVDKEKAKVAFFYSSPTVTDQNQWVKEAKAKISQEHPGWEIVTTQFGY--NDATKSLQTAEGIIKAYP 188 (316) T ss_dssp HHHHHHHHHHHHHHCSSSEEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTEEEEEEEECT--TCHHHHHHHHHHHHHHCS T ss_pred HHHHHHHHHHHHHhCCCCCeEEEEECCCCcHHHHHHHHHHHHHHHHHCCCcEEEeeccCC--CCHHHHHHHHHHHHHHCC Confidence 6677777777543 5 678998875 33455667778888776531 23333211111 1112233445555421 2 Q NP_000836.2 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 274 ~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) ++++|+... +..+..+++++++.|+. ++.+++. T Consensus 189 ~~~~i~~~~-~~~a~~~~~al~~~g~~-~v~v~g~ 221 (316) T 1TJY_A 189 DLDAIIAPD-ANALPAAAQAAENLKRN-NLAIVGF 221 (316) T ss_dssp SCCEEEECS-TTHHHHHHHHHHHTTCC-SCEEEEB T ss_pred CCCEEEecC-CCchHHHHHHHHHcCCC-CcEEEEe Confidence 456665543 44556677787777762 3334443 No 283 >4O5A_A LacI family transcription regulator; structural genomics, PSI-Biology, protein structure; HET: SO4, GOL; 1.777A {Bifidobacterium animalis subsp. lactis} Probab=96.55 E-value=9.7e-06 Score=83.19 Aligned_cols=207 Identities=12% Similarity=0.108 Sum_probs=115.3 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) ..+..+||++.|.++.... ...++..+..+++.++++.+ + ++.+.+...+. ...+.+. T Consensus 65 ~~~~~~Igvv~~~~~~~~~-------~~~~~~~~~~g~~~~~~~~g--------~--~~~~~~~~~~~-----~~~~~~~ 122 (345) T 4O5A_A 65 QSRTRRIGLVLGYDPQLLS-------AEPYIMRLISGLGSALEERD--------Y--SLLVRMSMDDD-----DEVSILE 122 (345) T ss_dssp -CCCCEEEEEEECC---------------CHHHHHHHHHHHHGGGT--------C--EEEEEEECSSS-----HHHHHHH T ss_pred cCCCCEEEEEEeCChHHhc-------cChHHHHHHHHHHHHHHHCC--------C--EEEEEecCCCc-----cHHHHHH Confidence 4567899999987531000 01245567777777776542 2 23333332221 1112222 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) +++. ..++|++|+...+.....+..+....++|+|..+...+ .+.++++.+++.. T Consensus 123 ~~~~------------------~~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~ 177 (345) T 4O5A_A 123 DWIA------------------TGNVDALLLLNLEIGDPRIELMKNNPQMPCLALADSSL-------TSGLPTLMSDDAA 177 (345) T ss_dssp HHHH------------------HTCSSEEEECSCCTTCHHHHHHHTCTTSCEEEEECGGG-------TTTSCEEECCHHH T ss_pred HHHH------------------hCCCCEEEEeCCcCCChHHHHHHhCCCCCEEEEccccc-------CCCCCEEEeCcHH Confidence 2221 15788888755443332222333357999988765432 1345667777778 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~vi 278 (908) .+..+++++.+.+.++++++..... ....+.++|.+.+++. ++.+.. .... .+..+....+++++. ..++|+| T Consensus 178 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~-~~~~~~-~~~~--~~~~~~~~~~~~~l~~~~~~dai 253 (345) T 4O5A_A 178 ASGTMIRHLALFGHKNIARVAGPEELGHSYIRDAAFSEITTEL-GMRYRC-LHTD--YTPESGAEATKRLLSVEPRPTAI 253 (345) T ss_dssp HHHHHHHHHHHTTCCEEEEEECCTTSTTHHHHHHHHHHHHHHT-TCEEEE-EECC--SCHHHHHHHHHHHHHSSSCCSEE T ss_pred HHHHHHHHHHHcCCCeEEEEeCchhccchHHHHHHHHHHHHHh-CCceEE-EecC--CCHHHHHHHHHHHhcCCCCCCEE Confidence 8888888887778889999985332 4556778888888765 344321 1111 111223344455432 2367888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|+. T Consensus 254 ~~~~-d~~a~~~~~~l~~~g~~ 274 (345) T 4O5A_A 254 IYDN-DVMALAGESVASVKGVR 274 (345) T ss_dssp EESS-HHHHHHHHHHHHHHTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7764 44566788888887763 No 284 >3UUG_B Multiple sugar-binding periplasmic receptor ChvE; periplasmic binding protein, SUGAR-BINDING PROTEIN; HET: BDP; 1.75A {Agrobacterium tumefaciens} Probab=96.50 E-value=1.2e-05 Score=81.98 Aligned_cols=206 Identities=10% Similarity=0.011 Sum_probs=114.2 Template_Neff=11.400 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) +..+||++.|.... .++.....+++.++++.| + ++.+.+...+. +...+.++++ T Consensus 2 ~~~~Ig~v~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~~~l 55 (330) T 3UUG_B 2 DKGSVGIAMPTKSS------------ARWIDDGNNIVKQLQEAG--------Y--KTDLQYADDDI----PNQLSQIENM 55 (330) T ss_dssp CCCEEEEEECCSSS------------THHHHHHHHHHHHHHHTT--------C--EEEEEECTTCH----HHHHHHHHHH T ss_pred CCceEEEEcCCCCC------------HHHHHHhhHHHHHHHHcC--------C--EEEEEecCCCH----HHHHHHHHHH Confidence 46789999987521 245567778887777653 2 33344433332 1223333433 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) +. .+++++|+...+... ......+...++|+|..+...+. ..++++++.+++... T Consensus 56 ~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~~d~~~~ 111 (330) T 3UUG_B 56 VT-------------------KGVKVLVIASIDGTTLSDVLKQAGEQGIKVIAYDRLIRN-----SGDVSYYATFDNFQV 111 (330) T ss_dssp HH-------------------HTCSEEEECCSSGGGGHHHHHHHHHTTCEEEEESSCCCS-----CTTCCEEEEECHHHH T ss_pred Hh-------------------cCCCEEEEecCCccchHHHHHHHHHCCCEEEEEcCCCCC-----CCCccEEEEeChHHH Confidence 32 478887765433322 23445566789999987754331 123456677777777 Q NP_000836.2 203 AQAMVDIVTA-------LGWNYVSTLAS--EGNYGESGVEAFTQISREIGG-VCIAQSQK-------IPREPRPGEFEKI 265 (908) Q Consensus 203 ~~~~~~~l~~-------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~-i~v~~~~~-------~~~~~~~~~~~~~ 265 (908) +..+++++.+ .+.++++++.. ++..+..+.++|++.+++.+. ..+..... .....+..+.... T Consensus 112 ~~~~~~~l~~~~~~~~~~g~~~i~~i~~~~~~~~~~~~~~g~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~ 191 (330) T 3UUG_B 112 GVLQATSITDKLGLKDGKGPFNIELFGGSPDDNNAFFFYDGAMSVLKPYIDSGKLVVKSGQMGMDKVGTLRWDPATAQAR 191 (330) T ss_dssp HHHHHHHHHHHHTGGGTCCCEEEEECCCCTTCHHHHHHHHHHHHHHHHHHHHTSEECTTCCCSHHHHCCGGGCHHHHHHH T ss_pred HHHHHHHHHHHhcccCCCCCcEEEEEecCCCCccHHHHHHHHHHHhHHhhhcCcEEEeeCCcccccccccCCCHHHHHHH Confidence 7777777654 46778998873 334556677788877765421 11211100 0000111223344 Q NP_000836.2 266 IKRLLET----PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 266 ~~~l~~~----~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) +++++.. .++++|++.. +..+..+++++++.|+. T Consensus 192 ~~~~l~~~~~~~~~~ai~~~~-~~~a~~~~~al~~~g~~ 229 (330) T 3UUG_B 192 MDNLLSAYYTDAKVDAVLSPY-DGLSIGIISSLKGVGYG 229 (330) T ss_dssp HHHHHHHHCSSSCCCEEECSS-HHHHHHHHHHHHHTTCS T ss_pred HHHHHHhhcCCCCccEEEeCC-cHHHHHHHHHHHhCCCC Confidence 4555421 2367776664 44566778888877764 No 285 >3LKV_A uncharacterized CONSERVED DOMAIN PROTEIN; ATPase Binding Cassette, PSI, MCSG; HET: PHE; 2.2A {Vibrio cholerae} Probab=96.46 E-value=1.3e-05 Score=80.10 Aligned_cols=215 Identities=8% Similarity=0.110 Sum_probs=114.8 Template_Neff=12.100 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) .....++||++.|... .++.....+++.++++.+.. .|+++++.+.|+..++. ...+.+ T Consensus 4 ~~~~~~~I~~v~~~~~-------------~~~~~~~~~~~~~~~~~g~~----~g~~~~~~~~~~~~~~~----~~~~~~ 62 (302) T 3LKV_A 4 IMAKTAKVAVSQIVEH-------------PALDATRQGLLDGLKAKGYE----EGKNLEFDYKTAQGNPA----IAVQIA 62 (302) T ss_pred ccCCCeEEEEEcCCCC-------------HHHHHHHHHHHHHHHHhCCC----CCceEEEEEEcCCCCHH----HHHHHH Confidence 4456889999998642 24556667777666654321 24567776666544322 222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSD-----NTRYDFFSRV 195 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~-----~~~~~~~~~~ 195 (908) +++.. .+++++|+.... ....... . ..++|+|......+.... .....+++.+ T Consensus 63 ~~~~~-------------------~~~d~ii~~~~~-~~~~~~~-~-~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~ 120 (302) T 3LKV_A 63 RQFVG-------------------ENPDVLVGIATP-TAQALVS-A-TKTIPIVFTAVTDPVGAKLVKQLEQPGKNVTGL 120 (302) T ss_pred HHHHH-------------------CCCCEEEEeCCc-hHHHHHH-H-hcCCCEEEEcCCCCCccchhhcCCCCCCcEEEc Confidence 33322 478888874322 2222222 2 679999987754432110 0012233333 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLASEGN-YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~~~~-~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) +....++.+++++.+. +.+++++++.+.. ++..+.+++++.+++. ++.+...... +..+....++++. T Consensus 121 --~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~~----~~~~~~~~~~~~~-- 191 (302) T 3LKV_A 121 --SDLSPVEQHVELIKEILPNVKSIGVVYNPGEANAVSLMELLKLSAAKH-GIKLVEATAL----KSADVQSATQAIA-- 191 (302) T ss_pred --CHHHHHHHHHHHHHHHCCCCcEEEEEeCCCChhHHHHHHHHHHHHHcC-CCeEeEeeCC----CHHHHHHHHHHHC-- Confidence 3333456667776554 7789999985443 4556677788777664 3544322111 1123444455443 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~~ 308 (908) .++++|++..+ ..+..+++++.+.+...++.+++. T Consensus 192 ~~~~~i~~~~~-~~~~~~~~~~~~~~~~~~i~i~~~ 226 (302) T 3LKV_A 192 EKSDVIYALID-NTVASAIEGMIVAANQAKTPVFGA 226 (302) T ss_pred CCCCEEEECCc-hHHHHHHHHHHHCCCCCCCcEEEe Confidence 36788876653 345556666666554323444443 No 286 >4KQC_A Periplasmic binding protein/LacI transcriptional regulator; structural genomics, APC110243, ABC transporter; HET: NO3; 1.62A {Brachyspira murdochii} Probab=96.39 E-value=1.8e-05 Score=80.11 Aligned_cols=209 Identities=12% Similarity=0.062 Sum_probs=109.7 Template_Neff=11.600 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) ++..+||++.|.... .++..+..+++.++++. |+++.+...++..+. ....+.+++ T Consensus 2 ~~~~~I~~v~~~~~~------------~~~~~~~~~~~~~~~~~--------g~~~~~~~~~~~~~~----~~~~~~i~~ 57 (319) T 4KQC_A 2 NADPYIAVVSKGFQH------------KFWVTVRDGAEAAAKQN--------GVKISFVGPETESDS----KIQQDLLDS 57 (319) T ss_dssp CSSCEEEEECCCSSS------------THHHHHHHHHHHHHHHH--------TCEEEEECCSSTTCH----HHHHHHHHH T ss_pred CCCCeEEEEecCCCC------------HHHHHHHHHHHHHHHHc--------CCEEEEeCCCCCCCH----HHHHHHHHH Confidence 356889999984321 24566777887777764 344544433321221 123334444 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|+...+.........+...++|+|..+...+... .....++.+.+++... T Consensus 58 l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~--~~~~~~~~v~~d~~~~ 116 (319) T 4KQC_A 58 EIN-------------------KNPDAIAFAAVTGDFTEQIKRIKEKNIPLIGFDSGILPDQ--AQGAVLATASTDNRAA 116 (319) T ss_dssp HHH-------------------TCCSCEEECCCSSCCHHHHHHHHHTTCCEEEETTCSCGGG--CTTCEEEEEECCHHHH T ss_pred HHH-------------------hCCCEEEEcCCCcchHHHHHHHHHCCCCEEEEcCCCCccc--ccCceeEEEEcChHHH Confidence 432 4788887654433222334455678999998876433211 0123456677777777 Q NP_000836.2 203 AQAMVDIVTALGWN-----------YVSTLASE-GNYGESGVEAFTQISREIGGVCIA-------QSQKIPREPRPGEFE 263 (908) Q Consensus 203 ~~~~~~~l~~~~~~-----------~v~ii~~~-~~~~~~~~~~~~~~~~~~~~i~v~-------~~~~~~~~~~~~~~~ 263 (908) ++.+++++.+.+.+ +++++... +.....+.++|++.+++.+ .... .........+..+.. T Consensus 117 g~~~~~~l~~~~~~~i~~~~~~~~~~v~~~~~~~~~~~~~r~~g~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~ 195 (319) T 4KQC_A 117 AAIVADKMFEALKTRIAAFTSDNKAKIAVLQLDNSDTGIGRAEGFVKRFTELA-DGDAATAGKYALQVIVPTTQNEADIA 195 (319) T ss_dssp HHHHHHHHHHHHHHHHHTSBTTBCEEEEEECCCSSHHHHHHHHHHHHHHHHHH-HHSTTTTTSEEEEEECCSSSSHHHHH T ss_pred HHHHHHHHHHHHHHHhhhcCCCCcEEEEEEEeCCCcchHHHHHHHHHHHHhcc-CcchhhCcceeeEEEccCCCCHHHHH Confidence 88888877554443 34444422 3345566777877776642 2210 000000001111222 Q NP_000836.2 264 KIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 264 ~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ..++.+. ..++++|++.. +..+..+++++++.|. T Consensus 196 ~~~~~l~-~~~~~~i~~~~-~~~a~~~~~a~~~~g~ 229 (319) T 4KQC_A 196 NEVNALR-GKSVLGIYLSN-EAMARGFLVVYKSAEA 229 (319) T ss_dssp HHHHTTT-TTTCSEEEECS-HHHHHHHHHHCCBCST T ss_pred HHHHHHh-cCCceEEEEcC-HHHHHHHHHHHHhccc Confidence 3333332 24667777664 4455677777777664 No 287 >4WWH_A ABC TRANSPORTER SOLUTE BINDING PROTEIN; ABC TRANSPORTER SOLUTE BINDING PROTEIN; HET: MSE, TRS, GAL; 1.2A {Mycobacterium smegmatis} Probab=96.38 E-value=1.8e-05 Score=81.89 Aligned_cols=210 Identities=12% Similarity=0.038 Sum_probs=113.1 Template_Neff=11.000 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....+..+||++.|..+. .++.....+++.++++.| +++.+.+...+. +...+. T Consensus 30 ~~~~~~~~Igvv~~~~~~------------~~~~~~~~g~~~~~~~~g----------~~~~~~~~~~~~----~~~~~~ 83 (362) T 4WWH_A 30 GDGDAKGTVGIAMPTKSS------------ERWVADGQNMVDQFKAFG----------YDTDLQYGDDVV----QNQVSQ 83 (362) T ss_dssp ----CCCEEEEEECCSSS------------THHHHHHHHHHHHHHHTT----------CEEEEEECTTCH----HHHHHH T ss_pred ccCCCCceEEEEcCCCCC------------HHHHHHHhHHHHHHHHhC----------CeEEEeecCccH----HHHHHH Confidence 345678999999987532 234556677777776643 233344433332 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVS-IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~-~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .++|++|........ ......+...++|+|..+...+.. .+..+.+..+ T Consensus 84 ~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~-----~~~~~~v~~d 139 (362) T 4WWH_A 84 IENMIT-------------------KGVKLLVIAPIDGSSLTNTLQHAADLKIPVISYDRLIKGT-----PNVDYYATFD 139 (362) T ss_dssp HHHHHH-------------------TTCSEEEECCSSTTSCHHHHHHHHHTTCCEEEESSCCCSC-----SCCCEEEEEC T ss_pred HHHHHh-------------------cCCCEEEEecCChhhhHHHHHHHHHCCCCEEEeCCCCCCC-----CCCcEEEEec Confidence 443332 467877764433322 234455667899999877543310 1235566677 Q NP_000836.2 199 DSYQAQAMVDIVTA-------LGWNYVSTLAS--EGNYGESGVEAFTQISREIGG-VCIAQSQK-------IPREPRPGE 261 (908) Q Consensus 199 ~~~~~~~~~~~l~~-------~~~~~v~ii~~--~~~~~~~~~~~~~~~~~~~~~-i~v~~~~~-------~~~~~~~~~ 261 (908) +...++.+++++.+ .+.++|+++.. +......+.++|++.+++.+. ..+..... .....+..+ T Consensus 140 ~~~~g~~~~~~l~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 219 (362) T 4WWH_A 140 NTKVGVLQANYIVDTLGVADGKGPFNLELFAGSPDDNNATYFFQGAMSVLQPYIDSGKLVVKSGQTTFDQIATLRWDGGL 219 (362) T ss_dssp HHHHHHHHHHHHHHHHTGGGTCCCEEEEECBCCTTCTHHHHHHHHHHHHHHHHHHHTSEECTTCCCSHHHHBCGGGCHHH T ss_pred HHHHHHHHHHHHHHHhCCcCCCCCeEEEEEECCCCChhHHHHHHHHHHHhHhhccCCeEEEeeCccccccccccCCCHHH Confidence 77777888887754 46778998874 233455667778777765421 11211100 000011122 Q NP_000836.2 262 FEKIIKRLLET----PNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 262 ~~~~~~~l~~~----~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ....+++++.. .++++|++.. +..+..+++++++.|+. T Consensus 220 ~~~~~~~~l~~~~~~~~~daii~~~-~~~a~~~~~al~~~g~~ 261 (362) T 4WWH_A 220 AQSRMDNLLSQAYTSGRVDAVLSPY-DGISRGVISALKSAGYG 261 (362) T ss_dssp HHHHHHHCCCCCCSSSCCCEEECSS-HHHHHHHHHHHHHTTCS T ss_pred HHHHHHHHHHHHhcCCCccEEEeCC-hHHHHHHHHHHHHCCCC Confidence 34445555421 2567777654 34466677788777763 No 288 >3CS3_A Sugar-binding transcriptional regulator, LacI family; STRUCTURAL GENOMICS, SUGAR-BINDING TRANSCRIPTIONAL REGULATOR; HET: SO4; 2.4A {Enterococcus faecalis} Probab=96.37 E-value=1.8e-05 Score=78.05 Aligned_cols=194 Identities=11% Similarity=0.015 Sum_probs=113.5 Template_Neff=11.600 Q NP_000836.2 42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQ 121 (908) Q Consensus 42 ~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~ 121 (908) .++..+||++.|..+. .++.....+++.++++. |+++ .+.+...+ . + T Consensus 5 ~~~~~~Ig~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~--~~~~~~~~--------~---~ 51 (277) T 3CS3_A 5 RRQTNIIGVYLADYGG------------SFYGELLEGIKKGLALF--------DYEM--IVCSGKKS--------H---L 51 (277) T ss_dssp CCCCCEEEEEECSSCT------------TTHHHHHHHHHHHHHTT--------TCEE--EEEESTTT--------T---T T ss_pred cCCCCEEEEEECCCCC------------chHHHHHHHHHHHHHhc--------CCEE--EEEeCCch--------h---h Confidence 3567899999986432 25566777888777764 2333 33332211 0 1 Q NP_000836.2 122 ALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201 (908) Q Consensus 122 ~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~ 201 (908) .+.. ++++++|...... .......+...++|+|..+...+. +..+++..++.. T Consensus 52 ~~~~-------------------~~~d~ii~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~~-------~~~~~v~~d~~~ 104 (277) T 3CS3_A 52 FIPE-------------------KMVDGAIILDWTF-PTKEIEKFAERGHSIVVLDRTTEH-------RNIRQVLLDNRG 104 (277) T ss_dssp CCCT-------------------TTCSEEEEECTTS-CHHHHHHHHHTTCEEEESSSCCCS-------TTEEEEEECHHH T ss_pred cccc-------------------cccCEEEEeCCCC-ChHHHHHHHHCCCeEEEECCCCCc-------cCCcEEEeCcHH Confidence 1111 4678777633222 223445566789999988764431 345677777777 Q NP_000836.2 202 QAQAMVDIVTALGWNYVSTLASEGN--YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET--PNARA 277 (908) Q Consensus 202 ~~~~~~~~l~~~~~~~v~ii~~~~~--~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~--~~~~v 277 (908) .++.+++++.+.+.++++++..... ....+.+++++.+++. ++++... ... .+..+....++++++. .++++ T Consensus 105 ~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~l~~~~~~~~~ 180 (277) T 3CS3_A 105 GATQAIEQFVNVGSKKVLLLSGPEKGYDSQERLAVSTRELTRF-GIPYEII-QGD--FTEPSGYAAAKKILSQPQTEPVD 180 (277) T ss_dssp HHHHHHHHHHHTTCSCEEEEECCTTSHHHHHHHHHHHHHHHHT-TCCEEEE-ECC--SSHHHHHHHHHHHTTSCCCSSEE T ss_pred HHHHHHHHHHHCCCCeEEEEcCCCCCCCHHHHHHHHHHHHHHc-CCCCeEE-ecC--CChHHHHHHHHHHHcCCCCCCcE Confidence 8888888886667889999885432 4566778888887764 3443211 111 1112333445555432 25677 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++. ++..+..+++++++.|+. T Consensus 181 i~~~-~~~~a~~~~~~l~~~g~~ 202 (277) T 3CS3_A 181 VFAF-NDEMAIGVYKYVAETNYQ 202 (277) T ss_dssp EEES-SHHHHHHHHHHHTTSSCC T ss_pred EEEe-CHHHHHHHHHHHHHCCCC Confidence 5554 455567788888877764 No 289 >2H0A_A Transcriptional regulator; Transcription, regulator, repressor, Structural Genomics; 2.8A {Thermus thermophilus} Probab=96.30 E-value=2.4e-05 Score=76.97 Aligned_cols=144 Identities=12% Similarity=0.039 Sum_probs=83.5 Template_Neff=12.000 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|........ .....+...++|+|..+... +.++.+..++...++.+++++.+.+.++++++..+ T Consensus 54 ~~~d~ii~~~~~~~~-~~~~~~~~~~ipvv~~~~~~---------~~~~~v~~d~~~~~~~~~~~l~~~g~~~i~~~~~~ 123 (276) T 2H0A_A 54 YLTDGLILASYDLTE-RFEEGRLPTERPVVLVDAQN---------PRYDSVYLDNRLGGRLAGAYLARFPGPIFAIAVEE 123 (276) T ss_dssp CCCSEEEEESCCCC-------CCSCSSCEEEESSCC---------TTSEEEEECSHHHHHHHHHHHTTSSSCEEEEEECC T ss_pred hcCCEEEEeccCCCh-HHHHccCCcCCCEEEECCCC---------CCCCEEEEChHHHHHHHHHHHHhCCCCEEEEEeCC Confidence 478888865433322 23344566799999876542 23456667777778888888876688889888743 Q NP_000836.2 225 -------GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET-PNARAVIMFANEDDIRRILEAAKK 296 (908) Q Consensus 225 -------~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~-~~~~viv~~~~~~~~~~~l~~~~~ 296 (908) ..+...+.+++++.+++. ++.+.....+....+..+....++++++. .++++|++.. +..+..+++++++ T Consensus 124 ~~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~~-~~~a~~~~~~~~~ 201 (276) T 2H0A_A 124 EPDRAFRRTVFAERMAGFQEALKEA-GRPFSPDRLYITRHSQEGGRLALRHFLEKASPPLNVFAGA-DQVALGVLEEAVR 201 (276) T ss_dssp SCCC---CCHHHHHHHHHHHHHHHT-TCCCCGGGEEEECSSHHHHHHHHHHHHTTCCSSEEEECSS-HHHHHHHHHHHHT T ss_pred CCchHhhhhHHHHHHHHHHHHHHHc-CCCCChhheEEecCChHHHHHHHHHHHHhcCCCCEEEECC-HHHHHHHHHHHHH Confidence 234556778888888765 34432211111001112233444555421 2477776653 4456678888888 Q NP_000836.2 297 LNQS 300 (908) Q Consensus 297 ~g~~ 300 (908) .|+. T Consensus 202 ~g~~ 205 (276) T 2H0A_A 202 LGLT 205 (276) T ss_dssp TSCT T ss_pred CCCC Confidence 7764 No 290 >3E61_B Putative transcriptional repressor of ribose; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: GOL; 2.0A {Staphylococcus saprophyticus subsp. saprophyticus} Probab=96.28 E-value=2.5e-05 Score=77.04 Aligned_cols=197 Identities=11% Similarity=0.029 Sum_probs=106.2 Template_Neff=11.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++.+||++.|..+. .+......+++.++++.+ + ++.+.+...+. ....+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 57 (277) T 3E61_B 4 YKRKSKLIGLLLPDMSN------------PFFTLIARGVEDVALAHG--------Y--QVLIGNSDNDI----KKAQGYL 57 (277) T ss_dssp ------CEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--CEEEEECTTCH----HHHHHHH T ss_pred CCCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC--------C--eEEEEeCCCCH----HHHHHHH Confidence 34567899999986432 245567777777776642 2 33344433321 2223344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|....+.. .....+...++|+|..+...+ ....+..++. T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~---------~~~~v~~d~~ 107 (277) T 3E61_B 58 ATFVS-------------------HNCTGMISTAFNEN--IIENTLTDHHIPFVFIDRINN---------EHNGISTNHF 107 (277) T ss_dssp HHHHH-------------------TTCSEEEECGGGHH--HHHHHHHHTTCCEEECC---------------CBCCCCHH T ss_pred HHHHH-------------------cCCCEEEEeCCCch--HHHHHHHHCCCCEEEECCCCC---------CCCEEEeChH Confidence 43332 47888876543322 223455678999998775432 2345666667 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+.++++++.... .....+.+++++.+++. ++.+.... .. .........+.+. ..++++| T Consensus 108 ~~~~~~~~~l~~~~~~~v~~~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~l~-~~~~~ai 181 (277) T 3E61_B 108 KGGQLQAEVVRKGKGKNVLIVHENLLIDAFHQRVQGIKYILDQQ-RIDYKMLE-AT---LLDNDKKFIDLIK-ELSIDSI 181 (277) T ss_dssp HHHHHHHHHHHHTTCSEEEEEECCTTSHHHHHHHHHHHHHHHHT-TCEEEEEE-GG---GGSSHHHHHHHHH-HTTCCEE T ss_pred HHHHHHHHHHHcCCCCeEEEEeCCCCChHHHHHHHHHHHHHHHC-CCChHHHh-hh---cccchHHHHHHHh-hCCCCEE Confidence 7777788887665667888887532 34556777888777764 34332111 11 0111222222232 2467888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|.. T Consensus 182 ~~~~-d~~a~~~~~al~~~g~~ 202 (277) T 3E61_B 182 ICSN-DLLAINVLGIVQRYHFK 202 (277) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7764 44566777888777763 No 291 >3E61_A Putative transcriptional repressor of ribose; STRUCTURAL GENOMICS, TRANSCRIPTION, DNA-binding, Transcription; HET: GOL; 2.0A {Staphylococcus saprophyticus subsp. saprophyticus} Probab=96.28 E-value=2.5e-05 Score=77.04 Aligned_cols=197 Identities=11% Similarity=0.029 Sum_probs=101.8 Template_Neff=11.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...++.+||++.|..+. .+......+++.++++.+ + ++.+.+...+. ....+.+ T Consensus 4 ~~~~~~~Ig~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~----~~~~~~~ 57 (277) T 3E61_A 4 YKRKSKLIGLLLPDMSN------------PFFTLIARGVEDVALAHG--------Y--QVLIGNSDNDI----KKAQGYL 57 (277) T ss_dssp ------CEEEEESCTTS------------HHHHHHHHHHHHHHHHTT--------C--CEEEEECTTCH----HHHHHHH T ss_pred CCCCCCEEEEEeCCCCC------------HHHHHHHHHHHHHHHHCC--------C--eEEEEeCCCCH----HHHHHHH Confidence 34567899999986432 245567777777776642 2 33344433321 2223344 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|....+.. .....+...++|+|..+...+ ....+..++. T Consensus 58 ~~l~~-------------------~~~d~ii~~~~~~~--~~~~~~~~~~ipvv~~~~~~~---------~~~~v~~d~~ 107 (277) T 3E61_A 58 ATFVS-------------------HNCTGMISTAFNEN--IIENTLTDHHIPFVFIDRINN---------EHNGISTNHF 107 (277) T ss_dssp HHHHH-------------------TTCSEEEECGGGHH--HHHHHHHHC-CCEEEGGGCC------------------HH T ss_pred HHHHH-------------------cCCCEEEEeCCCch--HHHHHHHHCCCCEEEECCCCC---------CCCEEEeChH Confidence 43332 47888876543322 223455678999998775432 2345666667 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) ..++.+++++.+.+.++++++.... .....+.+++++.+++. ++.+.... .. .........+.+. ..++++| T Consensus 108 ~~~~~~~~~l~~~~~~~v~~~~~~~~~~~~~~r~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~l~-~~~~~ai 181 (277) T 3E61_A 108 KGGQLQAEVVRKGKGKNVLIVHENLLIDAFHQRVQGIKYILDQQ-RIDYKMLE-AT---LLDNDKKFIDLIK-ELSIDSI 181 (277) T ss_dssp HHHHHHHHHHHHTTCCSEEEEESCTTSHHHHHHHHHHHHHHHC----CEEEEE-GG---GGGSHHHHHHHHH-HHTCCEE T ss_pred HHHHHHHHHHHcCCCCeEEEEeCCCCChHHHHHHHHHHHHHHHC-CCChHHHh-hh---cccchHHHHHHHh-hCCCCEE Confidence 7777788887665667888887532 34556777888777764 34332111 11 0111222222232 2467888 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++.. +..+..+++++++.|.. T Consensus 182 ~~~~-d~~a~~~~~al~~~g~~ 202 (277) T 3E61_A 182 ICSN-DLLAINVLGIVQRYHFK 202 (277) T ss_dssp EESS-HHHHHHHHHHHHHTTCC T ss_pred EECC-HHHHHHHHHHHHHcCCC Confidence 7764 44566777888777763 No 292 >6HNI_A ABC-type transport system, sugar-family extracellular; Substrate binding protein, adhesin, tyrosine; HET: TYR, EDO; 1.35A {Peptoclostridium difficile 630} Probab=96.19 E-value=3.4e-05 Score=77.89 Aligned_cols=218 Identities=9% Similarity=0.062 Sum_probs=114.9 Template_Neff=11.800 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|.++ .++.....+++.++++.+.. .|+++++.+.|...+. ....+ T Consensus 17 ~~~~~~~~~Igvv~~~~~-------------~~~~~~~~g~~~~~~~~g~~----~g~~i~~~~~~~~~~~----~~~~~ 75 (319) T 6HNI_A 17 NSKDKEVKKIGITQLVEH-------------PALDATRTGFVKALEKNGFK----DGENIDIDFQNAQNDM----PTTQS 75 (319) T ss_pred HhhcCCceEEEEEecCCC-------------HHHHHHHHHHHHHHHHhCCC----CCceEEEEEECCCCCH----HHHHH Confidence 345667899999998653 24556777777777664321 1345666666654332 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRV 195 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~ 195 (908) .++++.. .++|++|+...... ..... ...++|+|..+...+..... ...++.+.+ T Consensus 76 ~~~~~~~-------------------~~~d~ii~~~~~~~-~~~~~--~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~ 133 (319) T 6HNI_A 76 IASKFAS-------------------DKKDLIFAISTPSA-QAAFN--ATKDIPILITAVSDPVAAGLVKTLEKPGTNVS 133 (319) T ss_pred HHHHHHH-------------------CCCCEEEEeCCchH-HHHHH--HHcCCCEEEEcCCCCCccccccCCCCCCcCee Confidence 3333322 47888876443322 22222 25799998876544321100 001122444 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ..+....++.+++++.+. +.++++++..+...+ ..+.+++++.+++. ++++..... .+..+....++++. T Consensus 134 ~~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~----~~~~~~~~~i~~~~-- 206 (319) T 6HNI_A 134 GTSDFVSVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKN-GFKVVEKGI----TTSNEVNQGISSLV-- 206 (319) T ss_pred ecCHHHHHHHHHHHHHHHCCCCcEEEEEeCCCChHHHHHHHHHHHHHHcC-CCEEeeeeC----CCHHHHHHHHHHhC-- Confidence 455555566677777554 788999998544332 34566777776654 344432111 11122334444442 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++.. +..+..+++++++.+...++.+++ T Consensus 207 ~~~~~i~~~~-~~~a~~~~~~~~~~~~~~~v~v~~ 240 (319) T 6HNI_A 207 GKIDVLYVPT-DNLVASSMPIVSKIATENKIPVIA 240 (319) T ss_pred CCCCEEEECC-hHHHHHHHHHHHHCCCCCCceEEE Confidence 3678887664 334556666776665532333443 No 293 >6HNJ_A ABC-type transport system, sugar-family extracellular; Substrate binding protein, adhesin, tyrosine; HET: PGE, EDO; 1.8A {Peptoclostridium difficile 630} Probab=96.19 E-value=3.4e-05 Score=77.89 Aligned_cols=218 Identities=9% Similarity=0.062 Sum_probs=114.9 Template_Neff=11.800 Q NP_000836.2 39 SIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLT 118 (908) Q Consensus 39 ~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~ 118 (908) .....+.++||++.|.++ .++.....+++.++++.+.. .|+++++.+.|...+. ....+ T Consensus 17 ~~~~~~~~~Igvv~~~~~-------------~~~~~~~~g~~~~~~~~g~~----~g~~i~~~~~~~~~~~----~~~~~ 75 (319) T 6HNJ_A 17 NSKDKEVKKIGITQLVEH-------------PALDATRTGFVKALEKNGFK----DGENIDIDFQNAQNDM----PTTQS 75 (319) T ss_pred HhhcCCceEEEEEecCCC-------------HHHHHHHHHHHHHHHHhCCC----CCceEEEEEECCCCCH----HHHHH Confidence 345667899999998653 24556777777777664321 1345666666654332 22233 Q NP_000836.2 119 FVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRV 195 (908) Q Consensus 119 ~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~ 195 (908) .++++.. .++|++|+...... ..... ...++|+|..+...+..... ...++.+.+ T Consensus 76 ~~~~~~~-------------------~~~d~ii~~~~~~~-~~~~~--~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~ 133 (319) T 6HNJ_A 76 IASKFAS-------------------DKKDLIFAISTPSA-QAAFN--ATKDIPILITAVSDPVAAGLVKTLEKPGTNVS 133 (319) T ss_pred HHHHHHH-------------------CCCCEEEEeCCchH-HHHHH--HHcCCCEEEEcCCCCCccccccCCCCCCcCee Confidence 3333322 47888876443322 22222 25799998876544321100 001122444 Q NP_000836.2 196 VPPDSYQAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLET 272 (908) Q Consensus 196 ~~~~~~~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~ 272 (908) ..+....++.+++++.+. +.++++++..+...+ ..+.+++++.+++. ++++..... .+..+....++++. T Consensus 134 ~~~~~~~~~~~~~~l~~~~~~~~~i~~i~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~~----~~~~~~~~~i~~~~-- 206 (319) T 6HNJ_A 134 GTSDFVSVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKN-GFKVVEKGI----TTSNEVNQGISSLV-- 206 (319) T ss_pred ecCHHHHHHHHHHHHHHHCCCCcEEEEEeCCCChHHHHHHHHHHHHHHcC-CCEEeeeeC----CCHHHHHHHHHHhC-- Confidence 455555566677777554 788999998544332 34566777776654 344432111 11122334444442 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIG 307 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g~~~~~~~i~ 307 (908) .++++|++.. +..+..+++++++.+...++.+++ T Consensus 207 ~~~~~i~~~~-~~~a~~~~~~~~~~~~~~~v~v~~ 240 (319) T 6HNJ_A 207 GKIDVLYVPT-DNLVASSMPIVSKIATENKIPVIA 240 (319) T ss_pred CCCCEEEECC-hHHHHHHHHHHHHCCCCCCceEEE Confidence 3678887664 334556666776665532333443 No 294 >3H75_A Periplasmic sugar-binding domain protein; Protein Structure Initiative II (PSI; HET: SO4; 1.6A {Pseudomonas fluorescens Pf-5} Probab=96.16 E-value=3.8e-05 Score=78.89 Aligned_cols=212 Identities=15% Similarity=0.069 Sum_probs=109.7 Template_Neff=10.900 Q NP_000836.2 44 GDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL 123 (908) Q Consensus 44 ~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l 123 (908) ..++||++.|.... ..+...+..+++.++++.+ + ++.+.+...++ ....+.++++ T Consensus 2 ~~~~I~~i~~~~~~-----------~~~~~~~~~g~~~~a~~~g--------~--~~~~~~~~~~~----~~~~~~~~~l 56 (350) T 3H75_A 2 SLTSVVFLNPGNST-----------ETFWVSYSQFMQAAARDLG--------L--DLRILYAERDP----QNTLQQAREL 56 (350) T ss_dssp -CCEEEEEECSCTT-----------CHHHHHHHHHHHHHHHHHT--------C--EEEEEECTTCH----HHHHHHHHHH T ss_pred CCeEEEEEcCCCCC-----------CHHHHHHHHHHHHHHHHhC--------C--EEEEEEcCCCH----HHHHHHHHHH Confidence 46789999986211 1245667777777777642 2 33444443332 1222333333 Q NP_000836.2 124 IEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSD-------NTRYDFFSRVV 196 (908) Q Consensus 124 ~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~-------~~~~~~~~~~~ 196 (908) +.. ..++|++|..............+...+||+|..+...+.... ....+++..+. T Consensus 57 ~~~-----------------~~~~d~ii~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~~v~ 119 (350) T 3H75_A 57 FQG-----------------RDKPDYLMLVNEQYVAPQILRLSQGSGIKLFIVNSPLTLDQRELIGQSRQNYSDWIGSMV 119 (350) T ss_dssp HHS-----------------SSCCSEEEEECCSSHHHHHHHHHTTSCCEEEEEESCCCTTTC------------CEEEEE T ss_pred HcC-----------------CCCCCEEEEeCCcccHHHHHHHHHhcCCeEEEECCCCCHHHHHHhcCcchhcccchhEee Confidence 210 046788776543322223445566789999987754332100 00012345666 Q NP_000836.2 197 PPDSYQAQAMVDIVTA-LGWN------YVSTLAS--EGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIK 267 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~-~~~~------~v~ii~~--~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~ 267 (908) .++...+..+++++.+ .+.+ +++++.. +......+.++|++.+++.+...+.... .. ..+..+....++ T Consensus 120 ~d~~~~g~~~~~~l~~~~g~~~~~~~~~i~~i~~~~~~~~~~~r~~g~~~~l~~~~~~~~~~~~-~~-~~~~~~~~~~~~ 197 (350) T 3H75_A 120 GDDEEAGYRMLKELLHKLGPVPAGHGIELLAFSGLKVTPAAQLRERGLRRALAEHPQVHLRQLV-YG-EWNRERAYRQAQ 197 (350) T ss_dssp CCHHHHHHHHHHHHHHHHCCCCSSCCEEEEEEESCTTSHHHHHHHHHHHHHHHHCTTEEEEEEE-EC-TTCHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHHhCCCCCCCCcEEEEEeCCCCCHHHHHHHHHHHHHHHhCCCeEEEEEE-eC-CCCHHHHHHHHH Confidence 6777777777777643 4432 6777764 2334556778888887764312221111 11 011122334445 Q NP_000836.2 268 RLLE-TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 268 ~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ++++ ..++++|++.. +..+..+++++++.|+. T Consensus 198 ~~l~~~~~~~~i~~~~-d~~a~~~~~al~~~g~~ 230 (350) T 3H75_A 198 QLLKRYPKTQLVWSAN-DEMALGAMQAARELGRK 230 (350) T ss_dssp HHHHHCTTEEEEEESS-HHHHHHHHHHHHHTTCC T ss_pred HHHHHCCCCcEEEECC-HHHHHHHHHHHHHcCCC Confidence 5542 12466666553 44566778888887764 No 295 >4RKQ_A Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: EDO; 1.903A {Arthrobacter sp.} Probab=96.09 E-value=4.6e-05 Score=75.83 Aligned_cols=199 Identities=12% Similarity=0.049 Sum_probs=110.8 Template_Neff=11.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++. ...+. T Consensus 10 l~~~~~~~I~~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~ 63 (294) T 4RKQ_A 10 LVQGARTSVGLAIPDLTN------------PYFPAFASSVVELATLRG--------W--HVVVDDYGHGGR----SGLDA 63 (294) T ss_dssp SCCSCCCEEEEEESCSSS------------THHHHHHHHHHHHHHHTT--------C--EEEEEECCSTTC----CHHHH T ss_pred HccCCCCeEEEEeCCCCC------------ccHHHHHHHHHHHHHHcC--------C--eEEEEeCCCChh----hHHHH Confidence 345678999999986432 245566777777766542 2 334444333221 22223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++.+ . +++|++|....+... .... . ..++|+|..+...+ +..+.+..+. T Consensus 64 ~~~~-~-------------------~~~d~ii~~~~~~~~-~~~~-~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 112 (294) T 4RKQ_A 64 VEHL-A-------------------PQVDAVIGYLGGYAD-QAQT-V-LGRRPLIVLDENPG--------GAAGSINFDY 112 (294) T ss_dssp HHHH-G-------------------GGCSEEEECCTTCHH-HHHH-H-HTTSCEEEESSCCT--------TCSEEEEECH T ss_pred HHHH-h-------------------hcCCEEEEeCCCchh-HHHH-H-hcCCCEEEECCCCC--------CCCCEEEeCH Confidence 3322 1 467887764333221 1111 2 46899988765332 2455667777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN-------YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~-------~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ...++.+++++.+.+.++++++..+.. +...+.+++.+.+++. ++.+... ... .+..+....+++++. T Consensus 113 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~l~~ 188 (294) T 4RKQ_A 113 QHAAKVAVAQLMDSKRQHIAYLEAGSASESDEPVPCTVRGKAVAGRLDEL-GASWSLI-VAE--ETAEAAREAAAAFLRE 188 (294) T ss_dssp HHHHHHHHHHHHHTTCSSEEEEEESCCTTSSSCCCCSHHHHHHHHHHHHT-TCCEEEE-EEC--SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHCCCCeEEEEecCCCCCCCCCCcchHHHHHHHHHHHHh-CCCceEE-ecC--ccHHHHHHHHHHHHHH Confidence 777888888876667889999885332 3456667777777765 3433211 111 111223344444442 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 189 ~~~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (294) T 4RKQ_A 189 HPETDGILAFN-DLMAAGVLKALSGSGRR 216 (294) T ss_dssp CTTCCEEEESS-HHHHHHHHHHHHHTTCC T ss_pred CCCCcEEEECC-HHHHHHHHHHHHHCCCC Confidence 12467776653 44566778888887764 No 296 >4RKQ_B Transcriptional regulator, LacI family; sugar binding, transcription regulation, Enzyme; HET: EDO; 1.903A {Arthrobacter sp.} Probab=96.09 E-value=4.6e-05 Score=75.83 Aligned_cols=199 Identities=12% Similarity=0.049 Sum_probs=108.6 Template_Neff=11.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ...++..+||++.|..+. .+...+..+++.++++.+ + ++.+.+...++. ...+. T Consensus 10 l~~~~~~~I~~i~~~~~~------------~~~~~~~~~~~~~~~~~g--------~--~~~~~~~~~~~~----~~~~~ 63 (294) T 4RKQ_B 10 LVQGARTSVGLAIPDLTN------------PYFPAFASSVVELATLRG--------W--HVVVDDYGHGGR----SGLDA 63 (294) T ss_dssp ----CCCEEEEEESCSSS------------THHHHHHHHHHHHHHHTT--------C--EEEEEECCSTTC----CHHHH T ss_pred HccCCCCeEEEEeCCCCC------------ccHHHHHHHHHHHHHHcC--------C--eEEEEeCCCChh----hHHHH Confidence 345678999999986432 245566777777766542 2 334444333221 22223 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) ++.+ . +++|++|....+... .... . ..++|+|..+...+ +..+.+..+. T Consensus 64 ~~~~-~-------------------~~~d~ii~~~~~~~~-~~~~-~-~~~ipvv~~~~~~~--------~~~~~v~~d~ 112 (294) T 4RKQ_B 64 VEHL-A-------------------PQVDAVIGYLGGYAD-QAQT-V-LGRRPLIVLDENPG--------GAAGSINFDY 112 (294) T ss_dssp HHHH-G-------------------GGCSEEEECCSSCHH-HHHH-H-HTTSCEEEESSCCT--------TCSEEEEECH T ss_pred HHHH-h-------------------hcCCEEEEeCCCchh-HHHH-H-hcCCCEEEECCCCC--------CCCCEEEeCH Confidence 3322 1 467887764333221 1111 2 46899988765332 2455667777 Q NP_000836.2 200 SYQAQAMVDIVTALGWNYVSTLASEGN-------YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 200 ~~~~~~~~~~l~~~~~~~v~ii~~~~~-------~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~- 271 (908) ...++.+++++.+.+.++++++..+.. +...+.+++.+.+++. ++.+... ... .+..+....+++++. T Consensus 113 ~~~~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~-~~~--~~~~~~~~~~~~~l~~ 188 (294) T 4RKQ_B 113 QHAAKVAVAQLMDSKRQHIAYLEAGSASESDEPVPCTVRGKAVAGRLDEL-GASWSLI-VAE--ETAEAAREAAAAFLRE 188 (294) T ss_dssp HHHHHHHHHHHHHTTCCSEEEEEECC------CCCCSHHHHHHHHHHHHH-TCCEEEE-EEC--SSHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHCCCCeEEEEecCCCCCCCCCCcchHHHHHHHHHHHHh-CCCceEE-ecC--ccHHHHHHHHHHHHHH Confidence 777888888876667889999885332 3456667777777765 3433211 111 111223344444442 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++++.|+. T Consensus 189 ~~~~~~i~~~~-~~~a~~~~~al~~~g~~ 216 (294) T 4RKQ_B 189 HPETDGILAFN-DLMAAGVLKALSGSGRR 216 (294) T ss_dssp CTTCCEEEESS-HHHHHHHHHHHHHHTCC T ss_pred CCCCcEEEECC-HHHHHHHHHHHHHCCCC Confidence 12467776653 44566778888887764 No 297 >3LFT_A uncharacterized protein; ABC, ATPase, cassette, L-Trp, PSI; HET: TRP; 1.35A {Streptococcus pneumoniae} Probab=96.03 E-value=5.4e-05 Score=75.11 Aligned_cols=202 Identities=15% Similarity=0.156 Sum_probs=105.7 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ..+||++.|.+. .++....++++.++++.+.. |.++++.+.|+..++. ...+.++++. T Consensus 2 ~~~I~~i~~~~~-------------~~~~~~~~~~~~~~~~~g~~-----~~~~~~~~~d~~~~~~----~~~~~~~~~~ 59 (295) T 3LFT_A 2 NAKIGVLQFVSH-------------PSLDLIYKGIQDGLAEEGYK-----DDQVKIDFMNSEGDQS----KVATMSKQLV 59 (295) T ss_dssp CEEEEEEECSCC-------------HHHHHHHHHHHHHHHHTTCC-----GGGEEEEEEECTTCHH----HHHHHHHHHT T ss_pred CcEEEEEEccCC-------------HHHHHHHHHHHHHHHHcCCc-----cCeEEEEEECCCCCHH----HHHHHHHHHH Confidence 568999988742 25567788888888876422 2346666666543322 2223333332 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRVVPPDSY 201 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~~~~~~~ 201 (908) . .++|++|+.... ....+.. + ..++|+|..+...+..... ...+..+.+..+... T Consensus 60 ~-------------------~~~d~ii~~~~~-~~~~~~~-~-~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (295) T 3LFT_A 60 A-------------------NGNDLVVGIATP-AAQGLAS-A-TKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHN 117 (295) T ss_dssp T-------------------SSCSEEEEESHH-HHHHHHH-H-CSSSCEEEESCSCTTTTTSCSCSSCCCSSEEEEEECC T ss_pred H-------------------CCCCEEEEeCCH-HHHHHHH-h-cCCCCEEEEEcCChhhcchhhhccCCCCCcceecCCC Confidence 2 478888864332 2222222 2 5799998876544321100 000111223333334 Q NP_000836.2 202 QAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) .++.+++++.+. +.+++++++.+..++ ..+.+++++.+++. ++++.... .. +..+....++++. .++++| T Consensus 118 ~~~~~~~~l~~~~~~~~~v~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~--~~~~~i 190 (295) T 3LFT_A 118 PAQQQVELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKA-GLTVETFA-VP---STNEIASTVTVMT--SKVDAI 190 (295) T ss_dssp CHHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEEEE-ES---SGGGHHHHHHHHT--TTCSEE T ss_pred cHHHHHHHHHHHCCCCcEEEEeecCCCCChHHHHHHHHHHHHHc-CCEEEEEE-eC---CHHHHHHHHHHhc--cCCCEE Confidence 455666666554 678899998654433 45667777777664 34443211 11 1123444444442 367777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g 298 (908) ++.. +..+..+++++.+.+ T Consensus 191 ~~~~-~~~~~~~~~~~~~~~ 209 (295) T 3LFT_A 191 WVPI-DNTIASGFPTVVSSN 209 (295) T ss_dssp EECS-CHHHHHTHHHHHHHT T ss_pred EECC-ChhhhcchhHHHHHH Confidence 6654 333444555555544 No 298 >3LFT_B uncharacterized protein; ABC, ATPase, cassette, L-Trp, PSI; HET: MSE, TRP; 1.35A {Streptococcus pneumoniae} Probab=96.03 E-value=5.4e-05 Score=75.11 Aligned_cols=202 Identities=15% Similarity=0.156 Sum_probs=103.1 Template_Neff=12.200 Q NP_000836.2 45 DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALI 124 (908) Q Consensus 45 ~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~l~ 124 (908) ..+||++.|.+. .++....++++.++++.+.. |.++++.+.|+..++. ...+.++++. T Consensus 2 ~~~I~~i~~~~~-------------~~~~~~~~~~~~~~~~~g~~-----~~~~~~~~~d~~~~~~----~~~~~~~~~~ 59 (295) T 3LFT_B 2 NAKIGVLQFVSH-------------PSLDLIYKGIQDGLAEEGYK-----DDQVKIDFMNSEGDQS----KVATMSKQLV 59 (295) T ss_dssp --CEEEEECSCC-------------HHHHHHHHHHHHHHHHTTC---------CCEEEEECTTCHH----HHHHHHHHHH T ss_pred CcEEEEEEccCC-------------HHHHHHHHHHHHHHHHcCCc-----cCeEEEEEECCCCCHH----HHHHHHHHHH Confidence 568999988742 25567788888888876422 2346666666543322 2223333332 Q NP_000836.2 125 EKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN---TRYDFFSRVVPPDSY 201 (908) Q Consensus 125 ~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~---~~~~~~~~~~~~~~~ 201 (908) . .++|++|+.... ....+.. + ..++|+|..+...+..... ...+..+.+..+... T Consensus 60 ~-------------------~~~d~ii~~~~~-~~~~~~~-~-~~~ipvv~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 117 (295) T 3LFT_B 60 A-------------------NGNDLVVGIATP-AAQGLAS-A-TKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHN 117 (295) T ss_dssp H-------------------SSCSEEEEESHH-HHHHHHH-H-CSSSCEEEESCSCTTTTTSCSCSSCCCSSEEEEEECC T ss_pred H-------------------CCCCEEEEeCCH-HHHHHHH-h-cCCCCEEEEEcCChhhcchhhhccCCCCCcceecCCC Confidence 2 478888864332 2222222 2 5799998876544321100 000111223333334 Q NP_000836.2 202 QAQAMVDIVTAL--GWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAV 278 (908) Q Consensus 202 ~~~~~~~~l~~~--~~~~v~ii~~~~~~~-~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~vi 278 (908) .++.+++++.+. +.+++++++.+..++ ..+.+++++.+++. ++++.... .. +..+....++++. .++++| T Consensus 118 ~~~~~~~~l~~~~~~~~~v~~l~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~~-~~---~~~~~~~~~~~~~--~~~~~i 190 (295) T 3LFT_B 118 PAQQQVELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKA-GLTVETFA-VP---STNEIASTVTVMT--SKVDAI 190 (295) T ss_dssp CHHHHHHHHHHHCTTCCEEEEEEETTCHHHHHHHHHHHHHHHHT-TCEEEEEE-ES---SGGGHHHHHHHHH--TTCSEE T ss_pred cHHHHHHHHHHHCCCCcEEEEeecCCCCChHHHHHHHHHHHHHc-CCEEEEEE-eC---CHHHHHHHHHHhc--cCCCEE Confidence 455666666554 678899998654433 45667777777664 34443211 11 1123444444442 367777 Q NP_000836.2 279 IMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 279 v~~~~~~~~~~~l~~~~~~g 298 (908) ++.. +..+..+++++.+.+ T Consensus 191 ~~~~-~~~~~~~~~~~~~~~ 209 (295) T 3LFT_B 191 WVPI-DNTIASGFPTVVSSN 209 (295) T ss_dssp EECS-CHHHHHTHHHHHHHT T ss_pred EECC-ChhhhcchhHHHHHH Confidence 6654 333444555555544 No 299 >3HS3_B Ribose operon repressor; PSI-II, NYSGXRC, 11235h, periplasmic binding; 1.6A {Lactobacillus acidophilus} Probab=95.74 E-value=0.00012 Score=71.98 Aligned_cols=195 Identities=13% Similarity=0.113 Sum_probs=106.9 Template_Neff=11.500 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ...+..+||++.|..+. .+......+++.++++. |+++.+...+. .++ ....+.+ T Consensus 6 ~~~~~~~Ig~v~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~~~~~~~-~~~----~~~~~~i 60 (277) T 3HS3_B 6 YQKKSKMIGIIIPDLNN------------RFYAQIIDGIQEVIQKE--------GYTALISFSTN-SDV----KKYQNAI 60 (277) T ss_dssp --CCCCEEEEEESCSCS------------HHHHHHHHHHHHHHHHT--------TCEEEEEECSS-CCH----HHHHHHH T ss_pred ccCCCCeEEEEeCCCCC------------hhHHHHHHHHHHHHHHc--------CCEEEEEecCC-CcH----HHHHHHH Confidence 34567899999986432 24556777777777664 23343332221 221 1222334 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~ 200 (908) ++++. .++|++|....+... ....++|+|..+...+. +....+..+.. T Consensus 61 ~~l~~-------------------~~~d~ii~~~~~~~~------~~~~~ipvv~~~~~~~~-------~~~~~v~~d~~ 108 (277) T 3HS3_B 61 INFEN-------------------NNVDGIITSAFTIPP------NFHLNTPLVMYDSANIN-------DDIVRIVSNNT 108 (277) T ss_dssp HHHHH-------------------TTCSEEEEECCCCCT------TCCCSSCEEEESCCCCC-------SSSEEEEECHH T ss_pred HHHHH-------------------CCCCEEEEeCCCCCc------ccccCCCEEEecCCCCC-------CCceEEEeccH Confidence 43332 478888865433221 13569999987764321 23455666777 Q NP_000836.2 201 YQAQAMVDIVTALGWNYVSTLASE--GNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TPNARA 277 (908) Q Consensus 201 ~~~~~~~~~l~~~~~~~v~ii~~~--~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v 277 (908) ..++.+++++.+. .++++++... ......+.++|++.+++. ++.+.... .. .......+.++++ ..++++ T Consensus 109 ~~~~~~~~~l~~~-~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~-~~----~~~~~~~~~~~l~~~~~~~~ 181 (277) T 3HS3_B 109 KGGKESIKLLSKK-IEKVLIQHWPLSLPTIRERIEAMTAEASKL-KIDYLLEE-TP----ENNPYISAQSALNKSNQFDA 181 (277) T ss_dssp HHHHHHHHTSCTT-CCEEEEEESCTTSHHHHHHHHHHHHHHHHT-TCEEEEEE-CC----SSCHHHHHHHHHHTGGGCSE T ss_pred HHHHHHHHHHHhc-CceEEEEeCCCCCHHHHHHHHHHHHHHHHC-CCceeecC-CC----CCCHHHHHHHHHhhCCCCCE Confidence 7777777777553 5788888743 334456777888877765 34432111 11 0111122233322 135777 Q NP_000836.2 278 VIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 278 iv~~~~~~~~~~~l~~~~~~g~~ 300 (908) |++.. +..+..+++++++.|+. T Consensus 182 i~~~~-d~~a~~~~~al~~~g~~ 203 (277) T 3HS3_B 182 IITVN-DLYAAEIIKEAKRRNLK 203 (277) T ss_dssp EECSS-HHHHHHHHHHHHHTTCC T ss_pred EEEcC-HHHHHHHHHHHHHCCCC Confidence 76663 44566778888887763 No 300 >3JVD_A Transcriptional regulators; STRUCTURAL GENOMICS, PSI-2, SUGAR BINDING; HET: SO4; 2.3A {Corynebacterium glutamicum} Probab=95.72 E-value=0.00012 Score=74.15 Aligned_cols=192 Identities=13% Similarity=0.121 Sum_probs=105.9 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .+..+||++.|..+. .++..+..+++.++++. |+++. +.+.. ++ +...+.+++ T Consensus 62 ~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~--~~~~~-~~----~~~~~~~~~ 114 (333) T 3JVD_A 62 HRSALVGVIVPDLSN------------EYYSESLQTIQQDLKAA--------GYQML--VAEAN-SV----QAQDVVMES 114 (333) T ss_dssp --CCEEEEEESCSSS------------HHHHHHHHHHHHHHHHH--------TCEEE--EEECC-SH----HHHHHHHHH T ss_pred CCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHc--------CCeEE--EEECC-CH----HHHHHHHHH Confidence 467889999886432 24556667777666553 22332 33322 11 122233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|...... .+...++|+|..+...+. +....+..++... T Consensus 115 l~~-------------------~~~d~ii~~~~~~-------~~~~~~ipvv~~~~~~~~-------~~~~~v~~d~~~~ 161 (333) T 3JVD_A 115 LIS-------------------IQAAGIIHVPVVG-------SIAPEGIPMVQLTRGELG-------PGFPRVLCDDEAG 161 (333) T ss_dssp HHH-------------------HTCSEEEECCCTT-------CCC-CCSCEEEECC-----------CCSCEEEECHHHH T ss_pred HHh-------------------cCCCEEEEecccc-------cccCCCCCEEEEcCCCCC-------CCCCEEEeCcHHH Confidence 332 4778887643221 356679999987764321 2345666666667 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +..+++++.+.++++++++.... .....+.++|++.+++. ++.+..... . .+..+....++.+++..++|++++ T Consensus 162 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~-~--~~~~~~~~~~~~~~~~~~~dai~~ 237 (333) T 3JVD_A 162 FFQLTESVLGGSGMNIAALVGEESLSTTQERMRGISHAASIY-GAEVTFHFG-H--YSVESGEEMAQVVFNNGLPDALIV 237 (333) T ss_dssp HHHHHHHHCCSSSCEEEEEESCTTSHHHHHHHHHHHHHHHHT-TCEEEEEEC-C--SSHHHHHHHHHHHHHTCCCSEEEE T ss_pred HHHHHHHHHcCCCCcEEEEECCcccchHHHHHHHHHHHHHHc-CCccEEEec-C--CCHHHHHHHHHHHHhCCCCCEEEE Confidence 77778887655788999887532 44566778888888775 344432100 0 111122334444432235778665 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~ 299 (908) .. +..+..+++++++.|+ T Consensus 238 ~~-d~~a~~~~~al~~~g~ 255 (333) T 3JVD_A 238 AS-PRLMAGVMRAFTRLNV 255 (333) T ss_dssp CC-HHHHHHHHHHHHHTTC T ss_pred CC-HHHHHHHHHHHHHCCC Confidence 53 5556678888888776 No 301 >3JVD_B Transcriptional regulators; STRUCTURAL GENOMICS, PSI-2, SUGAR BINDING; HET: SO4; 2.3A {Corynebacterium glutamicum} Probab=95.72 E-value=0.00012 Score=74.15 Aligned_cols=192 Identities=13% Similarity=0.121 Sum_probs=106.7 Template_Neff=11.400 Q NP_000836.2 43 DGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA 122 (908) Q Consensus 43 ~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~~~ 122 (908) .+..+||++.|..+. .++..+..+++.++++. |+++. +.+.. ++ +...+.+++ T Consensus 62 ~~~~~I~~i~~~~~~------------~~~~~~~~g~~~~~~~~--------g~~~~--~~~~~-~~----~~~~~~~~~ 114 (333) T 3JVD_B 62 HRSALVGVIVPDLSN------------EYYSESLQTIQQDLKAA--------GYQML--VAEAN-SV----QAQDVVMES 114 (333) T ss_dssp --CCEEEEEESCTTC------------HHHHTTHHHHHHHHHHT--------TCEEE--EEECC-SH----HHHHHHHHH T ss_pred CCCCEEEEEeCCCCC------------hhHHHHHHHHHHHHHHc--------CCeEE--EEECC-CH----HHHHHHHHH Confidence 467889999886432 24556667777666553 22332 33322 11 122233333 Q NP_000836.2 123 LIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 202 (908) Q Consensus 123 l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~ 202 (908) ++. .++|++|...... .+...++|+|..+...+. +....+..++... T Consensus 115 l~~-------------------~~~d~ii~~~~~~-------~~~~~~ipvv~~~~~~~~-------~~~~~v~~d~~~~ 161 (333) T 3JVD_B 115 LIS-------------------IQAAGIIHVPVVG-------SIAPEGIPMVQLTRGELG-------PGFPRVLCDDEAG 161 (333) T ss_dssp HHH-------------------TTCSEEEECCC-----------CCSSSCEEEESSCCCB-------TTBCEEEECHHHH T ss_pred HHh-------------------cCCCEEEEecccc-------cccCCCCCEEEEcCCCCC-------CCCCEEEeCcHHH Confidence 332 4778887643221 356679999987764321 2345666666667 Q NP_000836.2 203 AQAMVDIVTALGWNYVSTLASEG--NYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIM 280 (908) Q Consensus 203 ~~~~~~~l~~~~~~~v~ii~~~~--~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~ 280 (908) +..+++++.+.++++++++.... .....+.++|++.+++. ++.+..... . .+..+....++.+++..++|++++ T Consensus 162 ~~~~~~~l~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~-~--~~~~~~~~~~~~~~~~~~~dai~~ 237 (333) T 3JVD_B 162 FFQLTESVLGGSGMNIAALVGEESLSTTQERMRGISHAASIY-GAEVTFHFG-H--YSVESGEEMAQVVFNNGLPDALIV 237 (333) T ss_dssp HHHHHHHHCCSSSCEEEEEESCTTSHHHHHHHHHHHHHHHHT-TCEEEEEEC-C--SSHHHHHHHHHHHHHTCCCSEEEE T ss_pred HHHHHHHHHcCCCCcEEEEECCcccchHHHHHHHHHHHHHHc-CCccEEEec-C--CCHHHHHHHHHHHHhCCCCCEEEE Confidence 77778887655788999887532 44566778888888775 344432100 0 111122334444432235778665 Q NP_000836.2 281 FANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 281 ~~~~~~~~~~l~~~~~~g~ 299 (908) .. +..+..+++++++.|+ T Consensus 238 ~~-d~~a~~~~~al~~~g~ 255 (333) T 3JVD_B 238 AS-PRLMAGVMRAFTRLNV 255 (333) T ss_dssp CC-HHHHHHHHHHHHHTTC T ss_pred CC-HHHHHHHHHHHHHCCC Confidence 53 5556678888888776 No 302 >3S99_A Basic membrane lipoprotein; SSGCID, Basic membrane lipoprotein, Structural; HET: IOD, ADE; 2.05A {Brucella melitensis biovar Abortus} Probab=95.68 E-value=0.00014 Score=74.71 Aligned_cols=216 Identities=7% Similarity=-0.005 Sum_probs=102.9 Template_Neff=10.300 Q NP_000836.2 27 MMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC 106 (908) Q Consensus 27 ~~~~~~~~~~~~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~ 106 (908) ||...+ ...+......+..+||++.|..... ..+......+++.++++. |+.+++.+.+.. T Consensus 9 ~~~~~~-~~~~~~~~~~~~~~I~~v~~~~~~d----------~~~~~~~~~g~~~~~~~~--------g~~v~~~~~~~~ 69 (356) T 3S99_A 9 MGTLEA-QTQGPGSMAEEKLKVGFIYIGPPGD----------FGWTYQHDQARKELVEAL--------GDKVETTFLENV 69 (356) T ss_dssp ------------------CEEEEEECSSCGGG----------SSHHHHHHHHHHHHHHHH--------TTTEEEEEECSC T ss_pred cccccc-cCCCCCCccccccEEEEEEccCCCc----------cchHHHHHHHHHHHHHHH--------CCCeEEEEEecC Confidence 444333 3334446667889999999753210 024456667777666653 232344444432 Q NP_000836.2 107 SRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSD 185 (908) Q Consensus 107 ~~~~~a~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~ 185 (908) .+. ....+.+++++. .++|+||+...... ..+..+++ ..++|++..+...+ T Consensus 70 ~~~----~~~~~~i~~~~~-------------------~~~d~II~~~~~~~-~~~~~~~~~~~~ip~v~~~~~~~---- 121 (356) T 3S99_A 70 AEG----ADAERSIKRIAR-------------------AGNKLIFTTSFGYM-DPTVKVAKKFPDVKFEHATGYKT---- 121 (356) T ss_dssp CTT----HHHHHHHHHHHH-------------------TTCSEEEECSGGGH-HHHHHHHTTCTTSEEEEESCCCC---- T ss_pred CCh----hhHHHHHHHHHH-------------------cCCCEEEEcChhhh-HHHHHHHHHCCCCEEEEccCCCC---- Confidence 221 122233333332 57888886543322 22223333 36899888765332 Q NP_000836.2 186 NTRYDFFSRVVPPDSYQAQAMVDIVTA-LGWNYVSTLASEG-NYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGE 261 (908) Q Consensus 186 ~~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v~ii~~~~-~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~ 261 (908) .+++..+..+....+..++.++.. .+.++|+++.... .....+.++|.+.+++.+ .+.+... +..+. +... T Consensus 122 ---~~n~~~v~~d~~~~~~~ag~~~~~~~~~~~i~~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~d~~~ 196 (356) T 3S99_A 122 ---ADNMSAYNARFYEGRYVQGVIAAKMSKKGIAGYIGSVPVPEVVQGINSFMLGAQSVNPDFRVKVI--WVNSWFDPGK 196 (356) T ss_dssp ---BTTEEEEEECHHHHHHHHHHHHHHHCSSCEEEEEECCCCHHHHHHHHHHHHHHHTTCTTCEEEEE--ECSSSCCHHH T ss_pred ---CCCeEEEeeehHHHHHHHHHHHHHHcCCCeeEEEeCCCChHHhhhHHHHHHHHHHhCCCCEEEEE--EcCCCCChhH Confidence 134455556655566666665543 4667899887432 334566777777776532 1222111 11001 1112 Q NP_000836.2 262 FEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 262 ~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) ..+.+++++. .++|+|+...+ +..+++++++.+ T Consensus 197 ~~~~~~~ll~-~~~d~I~~~~~---a~~v~~a~~~~g 229 (356) T 3S99_A 197 EADAAKALID-QGVDIITQHTD---STAAIQVAHDRG 229 (356) T ss_dssp HHHHHHHHHH-TTCSEEEESSS---SSHHHHHHHHTT T ss_pred HHHHHHHHHH-CCCCEEEeCCC---CHHHHHHHHHcC Confidence 2344555553 47888877653 456777776654 No 303 >6DSP_B Autoinducer 2-binding protein LsrB; AI-2 receptor, SIGNALING PROTEIN; HET: PAV; 1.37A {Clostridium saccharobutylicum DSM 13864} Probab=95.34 E-value=0.00028 Score=71.90 Aligned_cols=221 Identities=6% Similarity=-0.041 Sum_probs=98.5 Template_Neff=11.100 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||++.+.... .+...+..+++.++++. |+++.+.. +...++ .... T Consensus 14 ~~~~~~~~~~Igvi~~~~~~------------~~~~~~~~g~~~~a~~~--------g~~~~~~~-~~~~~~----~~~~ 68 (347) T 6DSP_B 14 TNSSKKGNVTVTFIPKLTGN------------AFFESANKGAQKYSEQW--------GFKVDYEG-DANASA----ASQV 68 (347) T ss_dssp --------CEEEEECSCSSS------------HHHHHHHHHHHHHHHHH--------TCEEEECC-CSSCCH----HHHH T ss_pred cCccCCCCeEEEEEecCCCC------------HHHHHHHHHHHHHHHHH--------CCEEEEEc-CCCCCH----HHHH Confidence 34566778999999875332 24456667777666653 23333321 222221 1222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. +++|++|....... .......+...++|+|.++...+. .....+.+. T Consensus 69 ~~~~~l~~-------------------~~~d~ii~~~~~~~~~~~~~~~~~~~~ipvv~~~~~~~~-----~~~~~~~v~ 124 (347) T 6DSP_B 69 SVINKAVQ-------------------QGTNAICLSSVDAAGVKDALKAAADAGVTVTTWDSDVDP-----SVRKVMVSQ 124 (347) T ss_dssp HHHHHHHH-------------------TTCSEEEECCSCHHHHHHHHHHHHHTTCEEEEESSCCCG-----GGCSEEEES T ss_pred HHHHHHHH-------------------cCCCEEEEeCCChHHHHHHHHHHHHCCCEEEEECCCCCc-----ccceeEEee Confidence 33443332 47888776433222 223445566789999988754321 011233444 Q NP_000836.2 197 PPDSYQAQAMVDIVTALGWN------YVST--LAS-EG-N---YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFE 263 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~~~~~------~v~i--i~~-~~-~---~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~ 263 (908) .++...++.+++++.+.+.+ ++++ +.. .. . ....+...++...++..++.+.....+....+..+.. T Consensus 125 ~d~~~~g~~~~~~l~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 204 (347) T 6DSP_B 125 GTPEQLGQMLVQMGYDSLKERGKDPEKDAIKYCWHYSNATVTDQNSWQVEGEKYIKSKYPNWQNVAPDNYYSNQDAEQAI 204 (347) T ss_dssp CCHHHHHHHHHHHHHHHHHHTTCCTTTSCCEEEEEESCSSCHHHHHHHHHHHHHHHHHCTTCEESCTTCEECTTCHHHHH T ss_pred CCHHHHHHHHHHHHHHHHHhcCCCcccccceEEEEecCCCcchHHHHHHHHHHHHHHHCCCcEEccCCCCCCCCCHHHHH Confidence 55666677777776443322 3333 221 11 1 1112333343333322123322111001001112233 Q NP_000836.2 264 KIIKRLLET-PNARAVIMFANEDDIRRILEAAKKLNQS-GHFLWIGS 308 (908) Q Consensus 264 ~~~~~l~~~-~~~~viv~~~~~~~~~~~l~~~~~~g~~-~~~~~i~~ 308 (908) ..++++++. .++++|++. ++..+..+++++++.|+. .++.+++. T Consensus 205 ~~~~~~l~~~~~~dai~~~-~d~~a~~~~~al~~~g~~p~~v~v~g~ 250 (347) T 6DSP_B 205 SVGESILSAHSDIDLIICN-DSTALPGQAQAAQNKGLTAKNVTITGF 250 (347) T ss_dssp HHHHHHHHHCTTCCEEEEC-STTHHHHHHHHHHHTTCCTTTCEEEEB T ss_pred HHHHHHHHHCCCcCEEEEc-CCCchHHHHHHHHHCCCCCCCeEEEeC Confidence 445555431 246777663 444556778888887764 23444443 No 304 >2FQW_A Membrane lipoprotein tmpC; ABC transport system, ligand-binding protein; HET: NOS; 1.71A {Treponema pallidum} Probab=95.31 E-value=0.0003 Score=70.64 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=74.4 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTALGWNYVS 219 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~~~~~~v~ 219 (908) +++++||+...... .....++ +..++|++..+...+. .+++..+..+....+..+ ++++.+.+.++++ T Consensus 61 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~~~~~~~~~~g~~a~~~~~~~g~~~i~ 133 (318) T 2FQW_A 61 ENMGLVVACGSFLV-EAVIETSARFPKQKFLVIDAVVQD------RDNVVSAVFGQNEGSFLVGVAAALKAKEAGKSAVG 133 (318) T ss_dssp TTCSEEEEESGGGH-HHHHHHHHHCTTSCEEEESSCCCS------CTTEEEEEECHHHHHHHHHHHHHHHHHHTTCCEEE T ss_pred CCCCEEEEcCHHHH-HHHHHHHHHCCCCeEEEEeccCCC------cccEEEEeechhHHHHHHHHHHHHHHHHcCCCEEE Confidence 47888886543322 1222222 3458998887654321 122333334433333333 4455445678999 Q NP_000836.2 220 TLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 220 ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++.... .....+.++|++.+++.+ ..+.....+..+. +.....+.++++.. .++|+|+... +..+..+++++++. T Consensus 134 ~i~~~~~~~~~~~~~gf~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~ 210 (318) T 2FQW_A 134 FIVGMELGMMPLFEAGFEAGVKAVD-PDIQVVVEVANTFSDPQKGQALAAKLYD-SGVNVIFQVA-GGTGNGVIKEARDR 210 (318) T ss_dssp EEESCCSTTTHHHHHHHHHHHHHHC-TTCEEEEEECSCSSCHHHHHHHHHHHHH-TTCCEEEEEC-GGGHHHHHHHHHHH T ss_pred EEecccCcchhHHHHHHHHHHHHHC-CCCEEEEEEcCCCCCHHHHHHHHHHHHH-cCCCEEEEcC-cHHhHHHHHHHHHh Confidence 998432 344556677777776532 2211111111001 11123344555553 4788887764 33455677888777 Q NP_000836.2 298 NQS 300 (908) Q Consensus 298 g~~ 300 (908) |+. T Consensus 211 g~~ 213 (318) T 2FQW_A 211 RLN 213 (318) T ss_dssp HHT T ss_pred hcC Confidence 653 No 305 >2FQX_A Membrane lipoprotein tmpC; ABC transport system, ligand-binding protein; HET: GMP; 1.7A {Treponema pallidum} Probab=95.31 E-value=0.0003 Score=70.64 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=74.4 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTALGWNYVS 219 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~~~~~~v~ 219 (908) +++++||+...... .....++ +..++|++..+...+. .+++..+..+....+..+ ++++.+.+.++++ T Consensus 61 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~~~~~~~~~~g~~a~~~~~~~g~~~i~ 133 (318) T 2FQX_A 61 ENMGLVVACGSFLV-EAVIETSARFPKQKFLVIDAVVQD------RDNVVSAVFGQNEGSFLVGVAAALKAKEAGKSAVG 133 (318) T ss_dssp TTCSEEEEESTTTH-HHHHHHHHHCTTSCEEEESSCCCS------CTTEEEEEECHHHHHHHHHHHHHHHHHHTTCCEEE T ss_pred CCCCEEEEcCHHHH-HHHHHHHHHCCCCeEEEEeccCCC------cccEEEEeechhHHHHHHHHHHHHHHHHcCCCEEE Confidence 47888886543322 1222222 3458998887654321 122333334433333333 4455445678999 Q NP_000836.2 220 TLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 220 ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++.... .....+.++|++.+++.+ ..+.....+..+. +.....+.++++.. .++|+|+... +..+..+++++++. T Consensus 134 ~i~~~~~~~~~~~~~gf~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~ 210 (318) T 2FQX_A 134 FIVGMELGMMPLFEAGFEAGVKAVD-PDIQVVVEVANTFSDPQKGQALAAKLYD-SGVNVIFQVA-GGTGNGVIKEARDR 210 (318) T ss_dssp EEESCCSTTTHHHHHHHHHHHHHHC-TTCEEEEEECSCSSCHHHHHHHHHHHHH-TTCCEEEEEC-GGGHHHHHHHHHHH T ss_pred EEecccCcchhHHHHHHHHHHHHHC-CCCEEEEEEcCCCCCHHHHHHHHHHHHH-cCCCEEEEcC-cHHhHHHHHHHHHh Confidence 998432 344556677777776532 2211111111001 11123344555553 4788887764 33455677888777 Q NP_000836.2 298 NQS 300 (908) Q Consensus 298 g~~ 300 (908) |+. T Consensus 211 g~~ 213 (318) T 2FQX_A 211 RLN 213 (318) T ss_dssp HHT T ss_pred hcC Confidence 653 No 306 >2FQY_A Membrane lipoprotein tmpC; ABC receptor protein, nucleoside binding; HET: ADN; 1.9A {Treponema pallidum} Probab=95.31 E-value=0.0003 Score=70.64 Aligned_cols=146 Identities=10% Similarity=0.046 Sum_probs=74.4 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTALGWNYVS 219 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~~~~~~v~ 219 (908) +++++||+...... .....++ +..++|++..+...+. .+++..+..+....+..+ ++++.+.+.++++ T Consensus 61 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~~~~~~~~~~g~~a~~~~~~~g~~~i~ 133 (318) T 2FQY_A 61 ENMGLVVACGSFLV-EAVIETSARFPKQKFLVIDAVVQD------RDNVVSAVFGQNEGSFLVGVAAALKAKEAGKSAVG 133 (318) T ss_dssp TTCSEEEEESGGGH-HHHHHHHHHCTTSCEEEESSCCCS------CTTEEEEEECHHHHHHHHHHHHHHHHHHTTCSEEE T ss_pred CCCCEEEEcCHHHH-HHHHHHHHHCCCCeEEEEeccCCC------cccEEEEeechhHHHHHHHHHHHHHHHHcCCCEEE Confidence 47888886543322 1222222 3458998887654321 122333334433333333 4455445678999 Q NP_000836.2 220 TLASEG-NYGESGVEAFTQISREIGGVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 220 ii~~~~-~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) ++.... .....+.++|++.+++.+ ..+.....+..+. +.....+.++++.. .++|+|+... +..+..+++++++. T Consensus 134 ~i~~~~~~~~~~~~~gf~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~ 210 (318) T 2FQY_A 134 FIVGMELGMMPLFEAGFEAGVKAVD-PDIQVVVEVANTFSDPQKGQALAAKLYD-SGVNVIFQVA-GGTGNGVIKEARDR 210 (318) T ss_dssp EEESCCSTTTHHHHHHHHHHHHHHC-TTCEEEEEECSCSSCHHHHHHHHHHHHH-TTCCEEEEEC-HHHHHHHHHHHHHH T ss_pred EEecccCcchhHHHHHHHHHHHHHC-CCCEEEEEEcCCCCCHHHHHHHHHHHHH-cCCCEEEEcC-cHHhHHHHHHHHHh Confidence 998432 344556677777776532 2211111111001 11123344555553 4788887764 33455677888777 Q NP_000836.2 298 NQS 300 (908) Q Consensus 298 g~~ 300 (908) |+. T Consensus 211 g~~ 213 (318) T 2FQY_A 211 RLN 213 (318) T ss_dssp HHT T ss_pred hcC Confidence 653 No 307 >3H5T_A Transcriptional regulator, LacI family; Transcriptional regulator, DNA-dependent, Protein Structure; 2.53A {Corynebacterium glutamicum} Probab=95.00 E-value=0.00053 Score=70.44 Aligned_cols=146 Identities=15% Similarity=0.125 Sum_probs=82.3 Template_Neff=10.800 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|....... ......+...++|+|..+...+ .+.+..+..++...++.+++++.+.+.++|+++... T Consensus 127 ~~~dgii~~~~~~~-~~~~~~~~~~~ipvV~~~~~~~-------~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 198 (366) T 3H5T_A 127 AAVDGVVIYSVAKG-DPHIDAIRARGLPAVIADQPAR-------EEGMPFIAPNNRKAIAPAAQALIDAGHRKIGILSIR 198 (366) T ss_dssp CCCSCEEEESCCTT-CHHHHHHHHHTCCEEEESSCCS-------CTTCCEEEECHHHHTHHHHHHHHHTTCCSEEEEEEC T ss_pred CCCCEEEEEccCCC-ChHHHHHHHcCCCEEEeCCCcc-------cCCCCEEecChHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 47787775433322 2333455667999998875432 123445556667778888888876688899998743 Q NP_000836.2 225 G-------------------NYGESGVEAFTQISREIGGVCIAQSQKIPRE-PRPGEFEKIIKRLLE-TPNARAVIMFAN 283 (908) Q Consensus 225 ~-------------------~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~-~~~~~~~~~~~~l~~-~~~~~viv~~~~ 283 (908) . .....+.+++.+.+++. ++.+......... .+..+....++++++ ..++++|++.. T Consensus 199 ~~~~~~~~~~~~~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~ai~~~~- 276 (366) T 3H5T_A 199 LDRANNDGEVTRERLENAQYQVQRDRVRGAMEVFIEA-GIDPGTVPIMECWINNRQHNFEVAKELLETHPDLTAVLCTV- 276 (366) T ss_dssp CSSSCCCEECCHHHHHTCCCTTHHHHHHHHHHHHHHH-TCCGGGSCEEEESSCCHHHHHHHHHHHHHHCTTCCEEEESS- T ss_pred ccccCCCCccchHHHHhhchHHHHHHHHHHHHHHHHC-CCCCCCCccccccccchhhHHHHHHHHHHhCCCccEEEECC- Confidence 2 23445667777777664 3433211111000 011123334444442 12467776654 Q NP_000836.2 284 EDDIRRILEAAKKLNQS 300 (908) Q Consensus 284 ~~~~~~~l~~~~~~g~~ 300 (908) +..+..+++++.+.|+. T Consensus 277 d~~a~~~~~al~~~g~~ 293 (366) T 3H5T_A 277 DALAFGVLEYLKSVGKS 293 (366) T ss_dssp HHHHHHHHHHHHHTTCC T ss_pred HHHHHHHHHHHHHcCCC Confidence 44566777888777764 No 308 >6NDI_A Hypothetical Protein CD630_05490; Structural Genomics, Center for Structural; HET: MSE; 2.6A {Klebsiella pneumoniae subsp. pneumoniae} Probab=94.87 E-value=0.00064 Score=68.56 Aligned_cols=144 Identities=12% Similarity=0.080 Sum_probs=79.7 Template_Neff=11.600 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|........... ..+..++|+|..+...+ .+....+..++...++.+++++.+.+.++++++... T Consensus 119 ~~~d~ii~~~~~~~~~~~--~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 189 (334) T 6NDI_A 119 HRPDGIIFTTMGLRQVPL--PEKLLTLPCVLANCESL-------SQPVASYIPDDEQGQYDAVKALLAAGYRRPLCLHLP 189 (334) T ss_dssp TCCSEEEEEEEEEECCCS--CGGGSSSCSEEEEECCS-------SSCCEEEEECHHHHHHHHHHHHHHTTCCCEEEEECC T ss_pred cCCCEEEEeCCCCCCCCC--chHHcCCCEEEEcCCcc-------CCCceEEEcCCHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 478877764332222221 22347999988765432 123455666777778888888766788899998843 Q NP_000836.2 225 G--NYGESGVEAFTQISREIGGVCIAQSQ--KIP-REPRPG-EFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 225 ~--~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~-~~~~~~-~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) . .....+.++|++.+++. ++.+.... ... .+.... ......+.+++ ..++++|++.. +..+..+++++++. T Consensus 190 ~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ai~~~~-d~~a~~~~~~l~~~ 267 (334) T 6NDI_A 190 ASQPATIRRRRGLERACREA-GIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGKPGFDSVICGN-DRIAFMVYQTLLGQ 267 (334) T ss_dssp TTSHHHHHHHHHHHHHHHHT-TCCGGGSCEEECCSSGGGGGGHHHHHHHTEETTEESCSEEEESS-HHHHHHHHHHHHHT T ss_pred CCChHHHHHHHHHHHHHHHc-CCCcccccccccCCCCcccccHHHHHHHHHHhCCCCCcEEEECC-HHHHHHHHHHHHHC Confidence 2 24556777888887765 34332110 000 000011 11122233322 13567776653 44566788888887 Q NP_000836.2 298 NQ 299 (908) Q Consensus 298 g~ 299 (908) |+ T Consensus 268 g~ 269 (334) T 6NDI_A 268 GL 269 (334) T ss_dssp TC T ss_pred CC Confidence 76 No 309 >6NDI_B Hypothetical Protein CD630_05490; Structural Genomics, Center for Structural; HET: MSE; 2.6A {Klebsiella pneumoniae subsp. pneumoniae} Probab=94.87 E-value=0.00064 Score=68.56 Aligned_cols=144 Identities=12% Similarity=0.080 Sum_probs=79.7 Template_Neff=11.600 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|........... ..+..++|+|..+...+ .+....+..++...++.+++++.+.+.++++++... T Consensus 119 ~~~d~ii~~~~~~~~~~~--~~~~~~ipvv~~~~~~~-------~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 189 (334) T 6NDI_B 119 HRPDGIIFTTMGLRQVPL--PEKLLTLPCVLANCESL-------SQPVASYIPDDEQGQYDAVKALLAAGYRRPLCLHLP 189 (334) T ss_dssp TCCSEEEEEEEEEECCCS--CGGGSSSCSEEEEECCS-------SSCCEEEEECHHHHHHHHHHHHHHTTCCCEEEEECC T ss_pred cCCCEEEEeCCCCCCCCC--chHHcCCCEEEEcCCcc-------CCCceEEEcCCHHHHHHHHHHHHHCCCCcEEEEeCC Confidence 478877764332222221 22347999988765432 123455666777778888888766788899998843 Q NP_000836.2 225 G--NYGESGVEAFTQISREIGGVCIAQSQ--KIP-REPRPG-EFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKL 297 (908) Q Consensus 225 ~--~~~~~~~~~~~~~~~~~~~i~v~~~~--~~~-~~~~~~-~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~ 297 (908) . .....+.++|++.+++. ++.+.... ... .+.... ......+.+++ ..++++|++.. +..+..+++++++. T Consensus 190 ~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ai~~~~-d~~a~~~~~~l~~~ 267 (334) T 6NDI_B 190 ASQPATIRRRRGLERACREA-GIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGKPGFDSVICGN-DRIAFMVYQTLLGQ 267 (334) T ss_dssp TTSHHHHHHHHHHHHHHHHT-TCCGGGSCEEECCSSGGGGGGHHHHHHHTEETTEESCSEEEESS-HHHHHHHHHHHHHT T ss_pred CCChHHHHHHHHHHHHHHHc-CCCcccccccccCCCCcccccHHHHHHHHHHhCCCCCcEEEECC-HHHHHHHHHHHHHC Confidence 2 24556777888887765 34332110 000 000011 11122233322 13567776653 44566788888887 Q NP_000836.2 298 NQ 299 (908) Q Consensus 298 g~ 299 (908) |+ T Consensus 268 g~ 269 (334) T 6NDI_B 268 GL 269 (334) T ss_dssp TC T ss_pred CC Confidence 76 No 310 >4IIL_A Membrane lipoprotein TpN38(b); periplasmic-binding protein, riboflavin transport, MEMBRANE; HET: EDO, RBF; 1.3A {Treponema pallidum subsp. pallidum} Probab=94.79 E-value=0.00072 Score=68.72 Aligned_cols=212 Identities=10% Similarity=0.067 Sum_probs=105.5 Template_Neff=10.600 Q NP_000836.2 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTF 119 (908) Q Consensus 40 ~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~ 119 (908) ....++.+||++.|..... ..+......+++.++++.|..+ .++.+ .+.+...+. +...+. T Consensus 27 ~~~~~~~~I~~i~~~~~~~----------~~~~~~~~~gi~~~~~~~~~~g---~~~~~--~~~~~~~~~----~~~~~~ 87 (346) T 4IIL_A 27 VQDERAVRIAVFVPGFRHD----------SPVYAMLCDGVERAVTQERATG---RSIGL--DIIEAGPNQ----ALWREK 87 (346) T ss_dssp ----CCEEEEEEESSCSTT----------CHHHHHHHHHHHHHHHHHHTTT---CCEEE--EEEECCSCG----GGHHHH T ss_pred CCCccCceEEEEeCCCCCC----------ChHHHHHHHHHHHHHHHHHhcc---ccccc--EEEEcCCCH----HHHHHH Confidence 4456789999999764211 1255677788888888765321 12233 333332121 122333 Q NP_000836.2 120 VQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198 (908) Q Consensus 120 ~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~ 198 (908) +++++. .+++|+||+...... .....++ ...++|+|..+...+. .+.+..+..+ T Consensus 88 l~~~~~------------------~~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~------~~~~~~v~~d 142 (346) T 4IIL_A 88 LAHLAA------------------EQRYRLIVSSNPALP-HVLEPILRQFPLQRFLVLDAYAPQ------EHSLITFRYN 142 (346) T ss_dssp HHHHHH------------------TTCCSEEEEESTTHH-HHHHHHHHHCTTCCEEEESCCCTT------CSSEEEEEEC T ss_pred HHHHHH------------------hCCCCEEEEcChhhH-HHHHHHHHHCCCCEEEEEeCCCCC------CCcEEEEEEc Confidence 333321 157888886543222 2222232 3568998887654321 1233444455 Q NP_000836.2 199 DSYQAQAMVDIVTA---------LGWNYVSTLASEGN-YGESG-VEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKI 265 (908) Q Consensus 199 ~~~~~~~~~~~l~~---------~~~~~v~ii~~~~~-~~~~~-~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~ 265 (908) ....+..++.++.. .+.++|+++..... ....+ .++|++.+++.+ .+++... +..+. +.....+. T Consensus 143 ~~~~~~~ag~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~r~~~gf~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~ 220 (346) T 4IIL_A 143 QWEQAYLAGHLSALVSASAMRFANADKKIGLIAGQSYPVMTQTIIPAFLAGARAVDPAFEVDVR--VVGNWYDAAKSADL 220 (346) T ss_dssp HHHHHHHHHHHHHHHHHSCCTTCCSSCEEEEEESSCCHHCCCCCHHHHHHHHHHHCTTCEEEEE--ECSSSSCHHHHHHH T ss_pred HHHHHHHHHHHHHHHhhhHhhhhcCCCEEEEEeCcCCcchhhhHHHHHHHHHHHhCCCCEEEEE--EecCCCCHHHHHHH Confidence 55455554444422 25678998885432 22233 677777776531 1222111 11001 11223445 Q NP_000836.2 266 IKRLLETPNARAVIMFANEDDIRRILEAAKKLNQ 299 (908) Q Consensus 266 ~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g~ 299 (908) ++++.. .++|+|+... +..+..+++++++.|. T Consensus 221 ~~~l~~-~~~d~i~~~~-~~~a~gv~~a~~~~gv 252 (346) T 4IIL_A 221 ARILFH-EGVDVMMPIC-GGANQGVLAAARELGF 252 (346) T ss_dssp HHHHHH-HTCCEEEEEC-GGGHHHHHHHCCCCCC T ss_pred HHHHHH-CCCCEEEECC-chhhHHHHHHHHHhCC Confidence 555553 4788887764 4445667777776653 No 311 >6PI6_C Atrazine periplasmic binding protein; SAD phasing, periplasmic binding protein; HET: OKM; 1.65A {Pseudomonas sp. (strain ADP)} Probab=94.78 E-value=0.00074 Score=68.92 Aligned_cols=206 Identities=6% Similarity=-0.033 Sum_probs=104.7 Template_Neff=10.200 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||+++|..... ..+......+++.++++.+ +.+.+.+.+...++ .... T Consensus 17 ~~~~~~~~~~I~~v~~~~~~d----------~~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~----~~~~ 74 (355) T 6PI6_C 17 RGSHMQEPLKVAFVYAGPVSD----------AGYTYAHDQGRLAMEKNLG--------AKVKSSYVENVPEG----ADAE 74 (355) T ss_dssp ------CCEEEEEECSSCGGG----------SSHHHHHHHHHHHHHHHHG--------GGEEEEEECSCCSG----GGHH T ss_pred CCCCCCCCeEEEEEEccCCCc----------cchHHHHHHHHHHHHHHhC--------CCcEEEEEecCCCc----ccHH Confidence 344566789999999864211 1245667777777777653 33443333322221 1222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .++|+||+...... ..+..++++ .++|+|..+...+ .+++..+. T Consensus 75 ~~l~~l~~-------------------~~~d~II~~~~~~~-~~~~~~a~~~~~i~~v~~~~~~~-------~~~~~~v~ 127 (355) T 6PI6_C 75 RVIRKLAA-------------------DGNKLIFTTSFGFM-NPTERVAKAFPNVVFEHATGVKL-------AKNLGVYE 127 (355) T ss_dssp HHHHHHHH-------------------TTCSEEEECSGGGH-HHHHHHHHHCTTSEEEEETCCCC-------BTTEEEEE T ss_pred HHHHHHHH-------------------CCCCEEEEcChhhH-HHHHHHHHHCCCCEEEEcccCCC-------cCCEEEec Confidence 33333332 46788876543322 223333433 6899988765432 12344555 Q NP_000836.2 197 PPDSYQAQAMVDIVTA-LGWNYVSTLASE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~-~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) .+....+..++.++.. .+.++|+++... ......+.++|.+.+++.+ .+.+... +.... +.....+.+++++. T Consensus 128 ~d~~~~g~~ag~~a~~~~~~~~i~~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~ll~- 204 (355) T 6PI6_C 128 SRQYEGTYLQGVLAAKMTKTGVIGFVGSFPVPEVIRNINAYTLGAQSVNPKIKTKVI--WVSTWYDPAKERQAAETLIA- 204 (355) T ss_dssp ECTHHHHHHHHHHHHHHCSSSEEEEEESCCSHHHHHHHHHHHHHHHTTCTTCEEEEE--ECSCSCCHHHHHHHHHHHHH- T ss_pred cchHHHHHHHHHHHHHHcCCCcEEEEeCCCchHHHHHHHHHHHHHHHhCCCCEEEEE--EccCCCCHHHHHHHHHHHHH- Confidence 5665566655555443 356789988743 2344566777877776532 1222111 11001 11122344555553 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .++|+|+...+ +..+++++++.| T Consensus 205 ~~~d~I~~~~~---a~gv~~a~~~~g 227 (355) T 6PI6_C 205 QGADVLTQNTN---SPATLQVAQEKG 227 (355) T ss_dssp TTCCEEEESSS---SSHHHHHHHHTT T ss_pred CCCCEEEeCCC---CHHHHHHHHHhC Confidence 47888877653 356677776655 No 312 >6PII_A Atrazine periplasmic binding protein; SAD phasing, periplasmic binding protein; HET: EMC, GUN, PO4; 1.87A {Pseudomonas sp. (strain ADP)} Probab=94.78 E-value=0.00074 Score=68.92 Aligned_cols=206 Identities=6% Similarity=-0.033 Sum_probs=106.5 Template_Neff=10.200 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||+++|..... ..+......+++.++++.+ +.+.+.+.+...++ .... T Consensus 17 ~~~~~~~~~~I~~v~~~~~~d----------~~~~~~~~~g~~~~~~~~g--------~~~~~~~~~~~~~~----~~~~ 74 (355) T 6PII_A 17 RGSHMQEPLKVAFVYAGPVSD----------AGYTYAHDQGRLAMEKNLG--------AKVKSSYVENVPEG----ADAE 74 (355) T ss_dssp ---CCCCCEEEEEECSSCGGG----------SSHHHHHHHHHHHHHHHHG--------GGEEEEEECSCCST----HHHH T ss_pred CCCCCCCCeEEEEEEccCCCc----------cchHHHHHHHHHHHHHHhC--------CCcEEEEEecCCCc----ccHH Confidence 344566789999999864211 1245667777777777653 33443333322221 1222 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVV 196 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~ 196 (908) +.+++++. .++|+||+...... ..+..++++ .++|+|..+...+ .+++..+. T Consensus 75 ~~l~~l~~-------------------~~~d~II~~~~~~~-~~~~~~a~~~~~i~~v~~~~~~~-------~~~~~~v~ 127 (355) T 6PII_A 75 RVIRKLAA-------------------DGNKLIFTTSFGFM-NPTERVAKAFPNVVFEHATGVKL-------AKNLGVYE 127 (355) T ss_dssp HHHHHHHH-------------------TTCSEEEECSGGGH-HHHHHHHHHCTTSEEEEESCCCC-------BTTEEEEE T ss_pred HHHHHHHH-------------------CCCCEEEEcChhhH-HHHHHHHHHCCCCEEEEcccCCC-------cCCEEEec Confidence 33333332 46788876543322 223333433 6899988765432 12344555 Q NP_000836.2 197 PPDSYQAQAMVDIVTA-LGWNYVSTLASE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKIIKRLLET 272 (908) Q Consensus 197 ~~~~~~~~~~~~~l~~-~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~ 272 (908) .+....+..++.++.. .+.++|+++... ......+.++|.+.+++.+ .+.+... +.... +.....+.+++++. T Consensus 128 ~d~~~~g~~ag~~a~~~~~~~~i~~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~ll~- 204 (355) T 6PII_A 128 SRQYEGTYLQGVLAAKMTKTGVIGFVGSFPVPEVIRNINAYTLGAQSVNPKIKTKVI--WVSTWYDPAKERQAAETLIA- 204 (355) T ss_dssp ECTHHHHHHHHHHHHHHCSSSEEEEEESCCCHHHHHHHHHHHHHHHTTCTTCEEEEE--ECSSSCCHHHHHHHHHHHHH- T ss_pred cchHHHHHHHHHHHHHHcCCCcEEEEeCCCchHHHHHHHHHHHHHHHhCCCCEEEEE--EccCCCCHHHHHHHHHHHHH- Confidence 5665566655555443 356789988743 2344566777877776532 1222111 11001 11122344555553 Q NP_000836.2 273 PNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 273 ~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .++|+|+...+ +..+++++++.| T Consensus 205 ~~~d~I~~~~~---a~gv~~a~~~~g 227 (355) T 6PII_A 205 QGADVLTQNTN---SPATLQVAQEKG 227 (355) T ss_dssp TTCCEEEESSS---SSHHHHHHHHTT T ss_pred CCCCEEEeCCC---CHHHHHHHHHhC Confidence 47888877653 356677776655 No 313 >6RQG_A 46 kDa surface antigen; immunodominant surface protein Mycoplasma hyopneumoniae; 3.1A {Mycoplasma hyopneumoniae J} Probab=94.68 E-value=0.00085 Score=68.97 Aligned_cols=92 Identities=14% Similarity=-0.013 Sum_probs=52.0 Template_Neff=8.700 Q NP_000836.2 145 DKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTAL---------- 213 (908) Q Consensus 145 ~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~---------- 213 (908) .++|++|...... ........+...++|+|.++...+.. ......+..++...++.+++++.+. T Consensus 76 ~~~dgIIi~~~~~~~~~~~~~~~~~~giPvV~~~~~~~~~-----~~~~~~V~~d~~~~g~~a~~~l~~~~~~~~~~~~~ 150 (387) T 6RQG_A 76 PAPKGFIIAPENGSGVGTAVNTIADKGIPIVAYDRLITGS-----DKYDWYVSFDNEKVGELQGLSLAAGLLGKEDGAFD 150 (387) T ss_dssp SCCSCEEECCSSTTTTHHHHHHHHTTTCCEEEESSCCCSC-----CCCCEEEEECHHHHHHHHHHHHHHHHHTCCSSCCS T ss_pred cCCCEEEEeCCCcccHHHHHHHHHHCCCCEEEEecCCCCC-----CcccEEEEcCHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 4678777543322 22233445667899999887643310 1234455566666666666665322 Q NP_000836.2 214 ---------------GWNYVSTLAS--EGNYGESGVEAFTQISRE 241 (908) Q Consensus 214 ---------------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~ 241 (908) +.++++++.. .+.....+.++|.+.+++ T Consensus 151 ~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~ 195 (387) T 6RQG_A 151 SIDQMNEYLKSHMPQETISFYTIAGSQDDNNSQYFYNGAMKVLKE 195 (387) T ss_dssp SHHHHHHHHHHTCCSSCEEEEECBCCTTSHHHHHHHHHHHHHHHH T ss_pred chHHHhHHHHHhCCCCceEEEEEECCCCChhHHHHHHHHHHHHHH Confidence 2467777753 223445567777777765 No 314 >6RUX_C Surface antigen P46; immunodominant surface protein Mycoplasma hyopneumoniae; HET: MAL; 2.5A {Mycoplasma hyopneumoniae J} Probab=94.68 E-value=0.00085 Score=68.97 Aligned_cols=92 Identities=14% Similarity=-0.013 Sum_probs=52.0 Template_Neff=8.700 Q NP_000836.2 145 DKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTAL---------- 213 (908) Q Consensus 145 ~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~---------- 213 (908) .++|++|...... ........+...++|+|.++...+.. ......+..++...++.+++++.+. T Consensus 76 ~~~dgIIi~~~~~~~~~~~~~~~~~~giPvV~~~~~~~~~-----~~~~~~V~~d~~~~g~~a~~~l~~~~~~~~~~~~~ 150 (387) T 6RUX_C 76 PAPKGFIIAPENGSGVGTAVNTIADKGIPIVAYDRLITGS-----DKYDWYVSFDNEKVGELQGLSLAAGLLGKEDGAFD 150 (387) T ss_dssp SCCSCEEECCSSTTTTHHHHHHHHTTTCCEEEESSCCCSC-----SCCCEEEEECHHHHHHHHHHHHHHHHTTCCSSCCS T ss_pred cCCCEEEEeCCCcccHHHHHHHHHHCCCCEEEEecCCCCC-----CcccEEEEcCHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 4678777543322 22233445667899999887643310 1234455566666666666665322 Q NP_000836.2 214 ---------------GWNYVSTLAS--EGNYGESGVEAFTQISRE 241 (908) Q Consensus 214 ---------------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~ 241 (908) +.++++++.. .+.....+.++|.+.+++ T Consensus 151 ~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~ 195 (387) T 6RUX_C 151 SIDQMNEYLKSHMPQETISFYTIAGSQDDNNSQYFYNGAMKVLKE 195 (387) T ss_dssp SHHHHHHHHHHTCCSSCEEEEECBCCTTSHHHHHHHHHHHHHHHH T ss_pred chHHHhHHHHHhCCCCceEEEEEECCCCChhHHHHHHHHHHHHHH Confidence 2467777753 223445567777777765 No 315 >6S3T_T 46 kDa surface antigen, Immunoglobulin; immunodominant surface protein Mycoplasma hyopneumoniae; HET: XYP; 3.5A {Mycoplasma hyopneumoniae J} Probab=94.68 E-value=0.00085 Score=68.97 Aligned_cols=92 Identities=14% Similarity=-0.013 Sum_probs=52.0 Template_Neff=8.700 Q NP_000836.2 145 DKISGVIGAAASS-VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTAL---------- 213 (908) Q Consensus 145 ~~v~~vIg~~~s~-~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~---------- 213 (908) .++|++|...... ........+...++|+|.++...+.. ......+..++...++.+++++.+. T Consensus 76 ~~~dgIIi~~~~~~~~~~~~~~~~~~giPvV~~~~~~~~~-----~~~~~~V~~d~~~~g~~a~~~l~~~~~~~~~~~~~ 150 (387) T 6S3T_T 76 PAPKGFIIAPENGSGVGTAVNTIADKGIPIVAYDRLITGS-----DKYDWYVSFDNEKVGELQGLSLAAGLLGKEDGAFD 150 (387) T ss_dssp SCCSCEEECCSSTTTTHHHHHHHHHTTCCEEEESSCCCSC-----CCCCEEEEECHHHHHHHHHHHHHHHHTTCCSSCCS T ss_pred cCCCEEEEeCCCcccHHHHHHHHHHCCCCEEEEecCCCCC-----CcccEEEEcCHHHHHHHHHHHHHHHhcCCCCCCcc Confidence 4678777543322 22233445667899999887643310 1234455566666666666665322 Q NP_000836.2 214 ---------------GWNYVSTLAS--EGNYGESGVEAFTQISRE 241 (908) Q Consensus 214 ---------------~~~~v~ii~~--~~~~~~~~~~~~~~~~~~ 241 (908) +.++++++.. .+.....+.++|.+.+++ T Consensus 151 ~~~~~~~~~~~~~~~g~~~i~~i~~~~~~~~~~~r~~g~~~~l~~ 195 (387) T 6S3T_T 151 SIDQMNEYLKSHMPQETISFYTIAGSQDDNNSQYFYNGAMKVLKE 195 (387) T ss_dssp CHHHHHHHHHHSCCSSCEEEEECBCCTTSTHHHHHHHHHHHHHHH T ss_pred chHHHhHHHHHhCCCCceEEEEEECCCCChhHHHHHHHHHHHHHH Confidence 2467777753 223445567777777765 No 316 >4FE4_A Xylose operon regulatory protein; dauixie, d-xylose, XylR, DNA looping; 3.45A {Escherichia coli} Probab=94.62 E-value=0.00092 Score=69.19 Aligned_cols=148 Identities=14% Similarity=0.103 Sum_probs=82.2 Template_Neff=11.500 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++|++|.+..+ ......++..++|+|..+...+... ..+....+..++...++.+++++.+.+.++++++... T Consensus 55 ~~~dgiI~~~~~---~~~~~~~~~~~ipvv~~~~~~~~~~---~~~~~~~v~~d~~~~g~~~~~~l~~~g~~~i~~i~~~ 128 (392) T 4FE4_A 55 WLGDGVIADFDD---KQIEQALADVDVPIVGVGGSYHLAE---SYPPVHYIATDNYALVESAFLHLKEKGVNRFAFYGLP 128 (392) T ss_dssp CCCSEEEEETTS---HHHHTTSTTCCSCEEEECBCCSSGG---GCCSSEECEECHHHHHHHHHHHHHHHSCCCEEEECCC T ss_pred hcCCEEEEeCCC---HHHHHHHhcCCCCEEEecCCccccC---CCCCCeEEEeCHHHHHHHHHHHHHHcCCCeEEEeCCc Confidence 467777765322 2233445667999998776432100 1234456667777778888888866678889988753 Q NP_000836.2 225 GN----YGESGVEAFTQISREIGGVCIAQSQKI-PREPRPGEFEKIIKRLLE-TPNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 225 ~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~-~~~~~~~~~~~~~~~l~~-~~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .. ....+.++|.+.+++. +......... ....+..+....++++++ ..++|+|++.. +..+..+++++.+.| T Consensus 129 ~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~ii~~~-d~~a~~~~~al~~~g 206 (392) T 4FE4_A 129 ESSGKRWATEREYAFRQLVAEE-KYRGVVYQGLETAPENWQHAQNRLADWLQTLPPQTGIIAVT-DARARHILQVCEHLH 206 (392) T ss_dssp TTSSCCHHHHHHHHHHHHHTTS-SSCEEEECCCCSSCSSHHHHHHHHHHHHHHSCSSEEEEESS-TTHHHHHHHHHHHTT T ss_pred hhhcchHHHHHHHHHHHHHHhh-ccceeecCCCCCCCccHHHHHHHHHHHHHcCCCCcEEEEeC-cHHHHHHHHHHHHcC Confidence 32 3456677888877654 2221111000 000111122334444432 12467776654 445667778888777 Q NP_000836.2 299 QS 300 (908) Q Consensus 299 ~~ 300 (908) +. T Consensus 207 ~~ 208 (392) T 4FE4_A 207 IP 208 (392) T ss_dssp CC T ss_pred CC Confidence 64 No 317 >4FE7_A Xylose operon regulatory protein; HTH_ARAC, Helix-turn-helix, PBP, periplasmic binding; HET: XYS; 2.9A {Escherichia coli} Probab=94.42 E-value=0.0012 Score=68.89 Aligned_cols=205 Identities=12% Similarity=0.051 Sum_probs=108.3 Template_Neff=11.100 Q NP_000836.2 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSL 117 (908) Q Consensus 38 ~~~~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~ 117 (908) ......+..+||++.|. .. .+...+..+++.++++.+ +.+.+ .+.. +. .. T Consensus 18 ~~~~~~~~~~I~v~~~~-~~------------~~~~~~~~g~~~~a~~~g--------~~~~~--~~~~-~~----~~-- 67 (412) T 4FE7_A 18 GSHMFTKRHRITLLFNA-NK------------AYDRQVVEGVGEYLQASQ--------SEWDI--FIEE-DF----RA-- 67 (412) T ss_dssp ---CCCCCEEEEEECCT-TS------------HHHHHHHHHHHHHHHHHT--------CCEEE--EECC--C----C--- T ss_pred CCCcCCCceEEEEEEeC-Cc------------HHHHHHHHHHHHHHHHcC--------CCcEE--Eeec-ch----Hh-- Confidence 34556678999999986 21 255667778777776643 22222 2221 11 11 Q NP_000836.2 118 TFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVP 197 (908) Q Consensus 118 ~~~~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~ 197 (908) .++.+.. ..+|++|.+... ......+...++|+|..+...+.. ...+....+.. T Consensus 68 -~~~~~~~-------------------~~~dgiI~~~~~---~~~~~~~~~~~ipvv~~~~~~~~~---~~~~~~~~v~~ 121 (412) T 4FE7_A 68 -RIDKIKD-------------------WLGDGVIADFDD---KQIEQALADVDVPIVGVGGSYHLA---ESYPPVHYIAT 121 (412) T ss_dssp ---------------------------CCCSEEEEETTC---HHHHHHHTTCCSCEEEEEECCSSG---GGSCSSEEEEE T ss_pred -hHHHHHh-------------------hCCCEEEEeCCC---HHHHHHHhcCCCCEEEecCCcccc---CCCCCCcEEEe Confidence 1222211 456777765322 223344566799999887643210 01233455667 Q NP_000836.2 198 PDSYQAQAMVDIVTALGWNYVSTLASEG----NYGESGVEAFTQISREIGGVCIAQSQK-IPREPRPGEFEKIIKRLLE- 271 (908) Q Consensus 198 ~~~~~~~~~~~~l~~~~~~~v~ii~~~~----~~~~~~~~~~~~~~~~~~~i~v~~~~~-~~~~~~~~~~~~~~~~l~~- 271 (908) ++...++.+++++.+.+.++++++.... .....+.++|++.+++. +........ .....+..+....++++++ T Consensus 122 d~~~~g~~a~~~l~~~g~~~i~~i~~~~~~~~~~~~~r~~g~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 200 (412) T 4FE7_A 122 DNYALVESAFLHLKEKGVNRFAFYGLPESSGKRWATEREYAFRQLVAEE-KYRGVVYQGLETAPENWQHAQNRLADWLQT 200 (412) T ss_dssp CHHHHHHHHHHHHHHTTCCEEEEECCCTTSCCHHHHHHHHHHHHHHTTS-SSCCEEECCSCSSCSSHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHcCCCeEEEecCCcccccchHHHHHHHHHHHHhhc-CceeeeecCcccCCccHHHHHHHHHHHHHc Confidence 7777788888888666778898887432 23556677888877764 232111100 0000111122334444432 Q NP_000836.2 272 TPNARAVIMFANEDDIRRILEAAKKLNQS 300 (908) Q Consensus 272 ~~~~~viv~~~~~~~~~~~l~~~~~~g~~ 300 (908) ..++++|++.. +..+..+++++.+.|+. T Consensus 201 ~~~~~~ii~~~-d~~a~~~~~al~~~g~~ 228 (412) T 4FE7_A 201 LPPQTGIIAVT-DARARHILQVCEHLHIP 228 (412) T ss_dssp SCTTEEEEESS-HHHHHHHHHHHHHHTCC T ss_pred CCCCeEEEEeC-cHHHHHHHHHHHHCCCC Confidence 12467776653 44556777788777764 No 318 >2HQB_A Transcriptional activator of comK gene; Berkeley Structure Genomics Center Target; 2.7A {Bacillus halodurans} Probab=93.50 E-value=0.0031 Score=61.96 Aligned_cols=140 Identities=9% Similarity=-0.001 Sum_probs=72.1 Template_Neff=11.200 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVT-ALGWNYVSTLA 222 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~-~~~~~~v~ii~ 222 (908) .++|+||....... .....+++. .++|+|..+...+ .+.+..+..+....+..++.++. ..+.++|+++. T Consensus 62 ~~~d~Ii~~~~~~~-~~~~~~a~~~~~i~~v~~~~~~~-------~~~~~~v~~d~~~~~~~a~~~~~~~~~~~~i~~i~ 133 (296) T 2HQB_A 62 GGVNLIFGHGHAFA-EYFSTIHNQYPDVHFVSFNGEVK-------GENITSLHFEGYAMGYFGGMVAASMSETHKVGVIA 133 (296) T ss_dssp TTCCEEEECSTHHH-HHHHTTTTSCTTSEEEEESCCCC-------SSSEEEEEECCHHHHHHHHHHHHHTCSSSEEEEEE T ss_pred CCCCEEEEeCHHHH-HHHHHHHHHCCCcEEEEecCCcC-------CCCEEEEEechhHHHHHHHHHHHHhcCCCcEEEEe Confidence 47888876543322 223333332 6899988765432 13344555555556666666654 45678899887 Q NP_000836.2 223 SEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPR-PGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 223 ~~~~~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~-~~~~~~~~~~l~~~~~~~viv~~~~~~~~~~~l~~~~~~g 298 (908) .... ..+.++|.+.+++.+...+.. .+..... .......++++.. .++|+|+... +..+..+++++++.| T Consensus 134 ~~~~--~~~~~gf~~~~~~~~~~~~~~--~~~~~~~d~~~~~~~~~~~~~-~~~d~i~~~~-~~~~~~~~~a~~~~g 204 (296) T 2HQB_A 134 AFPW--QPEVEGFVDGAKYMNESEAFV--RYVGEWTDADKALELFQELQK-EQVDVFYPAG-DGYHVPVVEAIKDQG 204 (296) T ss_dssp SCTT--CHHHHHHHHHHHHTTCCEEEE--EECSSSSCHHHHHHHHHHHHT-TTCCEEECCC-TTTHHHHHHHHHHHT T ss_pred cCCC--chHHHHHHHHHHHhCCCceEE--EEeCCCCCHHHHHHHHHHHHH-CCCCEEEEcC-CcccHHHHHHHHHcC Confidence 5432 235667776665432111110 0110011 1122334444443 4678877653 444556677776655 No 319 >6SHU_A Basic membrane protein D; transporter, nucleoside, purine, TRANSPORT PROTEIN; HET: ADN; 1.43002869382A {Borrelia burgdorferi (strain JD1)} Probab=93.26 E-value=0.0039 Score=63.47 Aligned_cols=205 Identities=10% Similarity=-0.043 Sum_probs=106.0 Template_Neff=10.300 Q NP_000836.2 41 RVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120 (908) Q Consensus 41 ~~~~~i~Ig~l~p~~~~~~~~~~c~~~~~~~~~~~~~a~~~A~~~iN~~~~il~g~~l~~~~~d~~~~~~~a~~~~~~~~ 120 (908) ......+||++.|..... ..+......+++.+.++.| +++ ...+. ++ ....+.+ T Consensus 43 ~~~~~~~I~~i~~~~~~d----------~~~~~~~~~g~~~~~~~~g--------~~~--~~~~~--~~----~~~~~~l 96 (361) T 6SHU_A 43 GKSEAKTVSLIVDGAFDD----------KGFNESSSKAIRKLKADLN--------INI--IEKAS--TG----NSYLGDI 96 (361) T ss_dssp -CCTTCEEEEEEESCSCS----------SSHHHHHHHHHHHHHHHHC--------CEE--EEEEE--CG----GGHHHHH T ss_pred CCcCCcEEEEEECCCCCC----------CchHHHHHHHHHHHHHHhC--------CeE--EEcCC--Cc----cchHHHH Confidence 445678999999853211 1245567777777776653 222 22221 11 1222333 Q NP_000836.2 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRL-FKIPQISYASTAPELSDNTRYDFFSRVVPPD 199 (908) Q Consensus 121 ~~l~~~~~~~~~~~~~~~~~~~~~~~v~~vIg~~~s~~~~~va~~~~~-~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~ 199 (908) +++.. .++|+||+..... ...+..+++. .++|++.++...+... ..+++..+..+. T Consensus 97 ~~l~~-------------------~~~d~II~~~~~~-~~~~~~~a~~~~~i~~v~~~~~~~~~~---~~~~~~~v~~d~ 153 (361) T 6SHU_A 97 ANLED-------------------GNSNLIWGIGFRL-SDILFQRASENVSVNYAIIEGVYDEIQ---IPKNLLNISFRS 153 (361) T ss_dssp HHHHH-------------------TTCSEEEEESGGG-HHHHHHHHHHCTTSCEEEESCCCSSCC---CCTTEEEEEECH T ss_pred HHHHh-------------------CCCCEEEEeChhh-HHHHHHHHHhCCCCcEEEeecCCcccc---CcCCEEEEEeCH Confidence 43332 4788888653322 2223333332 6899888776432100 123455566666 Q NP_000836.2 200 SYQAQAMVDIVTA-LGWNYVSTLASE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREP-RPGEFEKIIKRLLETPNA 275 (908) Q Consensus 200 ~~~~~~~~~~l~~-~~~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~ 275 (908) ...+..++.++.. .+.++|+++... ......+.++|.+.+++.+ .+.+... +..+. +.....+.++++.. .++ T Consensus 154 ~~~~~lag~~~~~~~~~~~ig~i~~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~--~~~~~~d~~~a~~~~~~~~~-~~~ 230 (361) T 6SHU_A 154 EEVAFLAGYFASKASKTGKIGFVGGVRGKVLESFMYGYEAGAKYANSNIKVVSQ--YVGTFGDFGLGRSTASNMYR-DGV 230 (361) T ss_dssp HHHHHHHHHHHHHHCSSSEEEEEESSCSHHHHHHHHHHHHHHHHHCTTCEEEEE--ECSSSSCHHHHHHHHHHHHH-TTC T ss_pred HHHHHHHHHHHHHHcCCCeEEEEeCCCChHHHHHHHHHHHHHHHHCcCCEEEEE--ECCCCCChHHHHHHHHHHHH-cCC Confidence 6666666666544 456789998743 2344556677777765532 1222111 11001 11123344555553 478 Q NP_000836.2 276 RAVIMFANEDDIRRILEAAKKLN 298 (908) Q Consensus 276 ~viv~~~~~~~~~~~l~~~~~~g 298 (908) |+|+... +..+..+++++++.| T Consensus 231 d~I~~~~-~~~~~g~~~a~~~~g 252 (361) T 6SHU_A 231 DIIFAAA-GLSGIGVIEAAKELG 252 (361) T ss_dssp CEEEEES-THHHHHHHHHHHHHC T ss_pred CEEEECC-chHHHHHHHHHHHHC Confidence 8887764 345566777777765 No 320 >4P98_A Basic membrane lipoprotein; Structural Genomics, PSI-Biology, Midwest Center; HET: MLY, MLZ, BR; 1.9A {Conexibacter woesei} Probab=91.79 E-value=0.01 Score=58.80 Aligned_cols=133 Identities=5% Similarity=-0.089 Sum_probs=64.4 Template_Neff=11.000 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILR-LFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTA-LGWNYVSTLA 222 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~-~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~-~~~~~v~ii~ 222 (908) +++|+||+...... .....+.+ ..++|++..+...+... ..+++..+..+....+..+..++.. .+.++|+++. T Consensus 74 ~~~d~Ii~~~~~~~-~~~~~~~~~~~~i~~v~~~~~~~~~~---~~~~~~~v~~~~~~~~~~ag~~~~~~~~~~~i~~i~ 149 (317) T 4P98_A 74 RGFDLVVGHGIDVS-EPILRVATEFPDVHFSASGDATLAER---LPPNVDGWTYDFGQLGYLDGFVAGSLRGVEKVGAVG 149 (317) T ss_dssp TTCSEEEEESHHHH-HHHHHHHTTCTTSEEEEECCGGGGGG---CCTTEEEEEECHHHHHHHHHHHHHTSSSCCEEEEEE T ss_pred CCCCEEEEeCHHhH-HHHHHHHHHCCCCEEEEccCcchhcc---CCCCeEEEEeehHHHHHHHHHHHHHHcCCCcEEEEe Confidence 57888886543321 22222222 35899887665332100 0234444555555455555544432 3567899987 Q NP_000836.2 223 SE-GNYGESGVEAFTQISREIG-GVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFAN 283 (908) Q Consensus 223 ~~-~~~~~~~~~~~~~~~~~~~-~i~v~~~~~~~~~~~~~~~~~~~~~l~~~~~~~viv~~~~ 283 (908) .. ......+.++|.+.+++.+ .+.+........ .+.....+.++++++ .++|+|+...+ T Consensus 150 ~~~~~~~~~~~~gf~~~~~~~~~~~~~~~~~~~~~-~d~~~~~~~~~~l~~-~~~d~i~~~~~ 210 (317) T 4P98_A 150 GPQLPFVLATHKGIRAGLKAANPRASYEETYTGRF-YDLQKEQEAARGLLD-KGAQLLVATDD 210 (317) T ss_dssp SSCCHHHHHHHHHHHHHHHHHCTTCEEEEEECSSS-SCHHHHHHHHHHHHH-TTCSSEEESSC T ss_pred CCCChHHHHHHHHHHHHHHHHCCCCEEEEEEccCC-CCHHHHHHHHHHHHH-CCCCEEEECCC Confidence 43 2234456677777776531 122221110000 011223345555553 47888777643 No 321 >4PEV_C solute binding protein; Structural Genomics, PSI-Biology, Midwest Center; HET: ADN, MSE; 2.58A {Aeropyrum pernix} Probab=90.15 E-value=0.022 Score=58.94 Aligned_cols=145 Identities=11% Similarity=-0.042 Sum_probs=70.8 Template_Neff=9.100 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANIL-RLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAM----VDIVTA-----LG 214 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~-~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~----~~~l~~-----~~ 214 (908) .++|+||....... .....++ ...++|++..+...+. ..+++..+..+....+..+ +.++.+ .+ T Consensus 110 ~g~D~II~~~~~~~-~~~~~~a~~~~~i~fv~~~~~~~~-----~~~nv~~v~~d~~~~g~laG~~aa~~~~~~~~~~~g 183 (422) T 4PEV_C 110 GEYDLIVLVGFLWQ-EPLEKVAPRYPEQKYALIDAATRE-----RYDNVASYLFREQEVASLVGIIAADIANNISKATGE 183 (422) T ss_dssp CCCSEEEEESGGGH-HHHHHHHHHCTTSEEEEESBCCSS-----CCTTEEEEEECHHHHHHHHHHHHHHHHHHHHHHHSS T ss_pred CCCCEEEEeCcccH-HHHHHHHHHCCCCeEEEEeCCCcc-----CCCCEEEEEECHHHHHHHHHHHHHHHHhhHhhhhCC Confidence 47888886543322 1122222 2468998877654321 0123334444444433333 333321 24 Q NP_000836.2 215 WNYVSTLASE-GNYGESGVEAFTQISREIG-----GVCIAQSQKIPREP-RPGEFEKIIKRLLETPNARAVIMFANEDDI 287 (908) Q Consensus 215 ~~~v~ii~~~-~~~~~~~~~~~~~~~~~~~-----~i~v~~~~~~~~~~-~~~~~~~~~~~l~~~~~~~viv~~~~~~~~ 287 (908) .++|++|... ......+.++|.+.+++.+ .+.+... +.... +.......++++.. .++|+|+... +... T Consensus 184 ~~~Ig~i~g~~~~~~~~~~~gf~~g~~~~~~~~~~~~~v~~~--~~~~~~d~~~a~~~a~~ll~-~g~dvI~~~~-~~~a 259 (422) T 4PEV_C 184 EAKAGAVAGMDIPPLWRFHIGYLYGVQYYNQAMGTDVEMVWT--YTGRFDDPTLGKTTAEQMLQ-QGVRVFYGVA-GLTH 259 (422) T ss_dssp CCEEEEEECCCSHHHHHHHHHHHHHHHHHHHTTTCCCCEEEE--ECSCSSCHHHHHHHHHHHHH-TTEEEEEEES-TTHH T ss_pred CCEEEEEECCCChHHHHHHHHHHHHHHHHCHhcCCCCEEEEE--EecCCCChHHHHHHHHHHHH-CCCCEEEEcc-chhh Confidence 6789888743 2334456667777665531 1122111 11001 11122344555553 4788877664 4445 Q NP_000836.2 288 RRILEAAKKLNQ 299 (908) Q Consensus 288 ~~~l~~~~~~g~ 299 (908) ..+++++++.++ T Consensus 260 ~gv~~a~~~~g~ 271 (422) T 4PEV_C 260 VGMFNAVKEAAA 271 (422) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 667777777765 No 322 >5ER3_A Sugar ABC transporter, periplasmic sugar-binding; Structural Genomics, PSI-Biology, Midwest Center; HET: GOL, MSE; 2.105A {Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)} Probab=89.00 E-value=0.032 Score=55.66 Aligned_cols=91 Identities=11% Similarity=-0.005 Sum_probs=54.2 Template_Neff=10.900 Q NP_000836.2 145 DKISGVIGAAASSV-SIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALG--WNYVSTL 221 (908) Q Consensus 145 ~~v~~vIg~~~s~~-~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~--~~~v~ii 221 (908) .++|++|....... .......+. .++|+|..+...+. ......+..++...++.+++++.+.+ .++++++ T Consensus 237 ~~~dgii~~~~~~~~~~~~~~~~~-~~ipvv~~~~~~~~------~~~~~~v~~d~~~~g~~aa~~l~~~~~~~~~i~~i 309 (341) T 5ER3_A 237 AKVDGIAISPIDPENQVAMINDAC-KVTPVICQDSDAPA------SRRKFYLGTSNYLAGRAAGKLIQEAIPEGGEVMLF 309 (341) T ss_dssp TTCSEEEECCSSGGGCHHHHHHHH-TTSCEEEESSCCTT------SCCSCEEECCHHHHHHHHHHHHHHHCTTCEEEEEE T ss_pred CCCCEEEECCCCHHHHHHHHHHHh-hCCCEEEEcCCCCc------ccCcEEEeCCHHHHHHHHHHHHHHHCCCCcEEEEE Confidence 46787775433322 122233445 68999987754321 12345566777777888888875543 3788888 Q NP_000836.2 222 ASEG--NYGESGVEAFTQISREI 242 (908) Q Consensus 222 ~~~~--~~~~~~~~~~~~~~~~~ 242 (908) .... .....+.++|++.+++. T Consensus 310 ~~~~~~~~~~~r~~g~~~~l~~~ 332 (341) T 5ER3_A 310 VGKMEVLNAQERSQGIMDELAGK 332 (341) T ss_dssp ESCTTSHHHHHHHHHHHHHHTTC T ss_pred ECCCCChhHHHHHHHHHHHHhcC Confidence 7432 23445667777777664 No 323 >3QI7_A Putative transcriptional regulator; PERIPLASMIC BINDING PROTEIN-LIKE, STRUCTURAL GENOMICS; 1.86A {Clostridium difficile} Probab=87.09 E-value=0.055 Score=54.67 Aligned_cols=152 Identities=12% Similarity=0.065 Sum_probs=79.5 Template_Neff=9.900 Q NP_000836.2 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASE 224 (908) Q Consensus 145 ~~v~~vIg~~~s~~~~~va~~~~~~~iP~Is~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~v~ii~~~ 224 (908) .++++++..............+...++|+|......+....-........+..++...++.+++++.+.+.++++++... T Consensus 86 ~~~d~ii~~~~~~~~~~~i~~~~~~gi~~iii~~~~~~~~~v~~~~~~~~V~~D~~~~g~~a~~~l~~~g~~~i~~i~~~ 165 (371) T 3QI7_A 86 KEVQAIVVSTDQAGLLPALQKVKEKRPEIITISAPMGDDKNQLSQFVDVNLGVSAEERGKVLAERSKEMGAKAFIHYAST 165 (371) T ss_dssp TTEEEEEEECSSCCCHHHHHHHHHHCTTSEEEESSCCSCHHHHHHHSSEEEECCHHHHHHHHHHHHHHTTCSCEEEEEET T ss_pred CCCcEEEEeCCCCchHHHHHHHHHhCCCEEEEeCCCCCChhHHcccccEEEECChHHHHHHHHHHHHHCCCCEEEEEeCC Confidence 46777775433322223334456678998877654321000000002344566666777778888766677788888743 Q NP_000836.2 225 GN----YGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLL---------ETPNARAVIMFANEDDIRRIL 291 (908) Q Consensus 225 ~~----~~~~~~~~~~~~~~~~~~i~v~~~~~~~~~~~~~~~~~~~~~l~---------~~~~~~viv~~~~~~~~~~~l 291 (908) .. ....+.++|++.+++. ++.+....... .........+++++ ...++++|+.. ++..+..++ T Consensus 166 ~~~~~~~~~~R~~gf~~~l~~~-gi~~~~~~~~~--~~~~~~~~~~~~~l~~~~~~~~~~~~~~~ai~~~-~d~~a~g~~ 241 (371) T 3QI7_A 166 DDLKDVNIAKRLEMIKETCKNI-GLPFVQVNTPN--INTEEDKNKVKQFLNEDIEKQVKKYGKDINVFGV-NEYMDEVIL 241 (371) T ss_dssp TGGGSHHHHHHHHHHHHHHHHT-TCCEEEEEECC--CSSTHHHHHHHHHHHHHHHHHHHHHCSCCEEEES-SHHHHHHHH T ss_pred ccccchhHHHHHHHHHHHHHHc-CCCeeeeecCC--CCCHHHHHHHHHHHHHHHHHHHHHHCCcEEEEEc-ChhhHHHHH Confidence 22 2456778888888875 35433211101 11111111222221 11346666654 344567788 Q NP_000836.2 292 EAAKKLNQS 300 (908) Q Consensus 292 ~~~~~~g~~ 300 (908) +++++.|.. T Consensus 242 ~al~~~g~~ 250 (371) T 3QI7_A 242 TKALELKYI 250 (371) T ss_dssp HHHHHHCCB T ss_pred HHHHHCCCE Confidence 888877763 No 324 >6U1N_R Muscarinic acetylcholine receptor M2,Vasopressin V2; Arrestin, GPCR, complex, signaling, SIGNALING; HET: SEP, 2CU, TPO;{Homo sapiens} Probab=78.82 E-value=0.23 Score=52.20 Aligned_cols=34 Identities=15% Similarity=0.117 Sum_probs=18.4 Template_Neff=11.800 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+...+-.+++= .-|.+.+. T Consensus 99 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 133 (509) T 6U1N_R 99 GPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVT 133 (509) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHTTTHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 36788888777665554443333333 33444443 No 325 >2Z73_A Rhodopsin; Visual pigment, Gq-type, G-Protein Coupled; HET: PLM, TWT, PC1, BOG, RET; 2.5A {Todarodes pacificus} Probab=72.81 E-value=0.44 Score=48.80 Aligned_cols=33 Identities=15% Similarity=0.097 Sum_probs=16.8 Template_Neff=11.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+++....-.+++ =..|...+. T Consensus 105 ~~~c~~~~~~~~~~~~~s~~~~~~isi~R~~ai~ 138 (448) T 2Z73_A 105 FAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIG 138 (448) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567887776665544433333332 234544443 No 326 >3AYN_A Rhodopsin; transmembrane protein, Photoreceptor, Chromophore, Glycoprotein; HET: PC1, PLM, BOG, RET; 2.7A {Todarodes pacificus} Probab=72.81 E-value=0.44 Score=48.80 Aligned_cols=33 Identities=15% Similarity=0.097 Sum_probs=16.8 Template_Neff=11.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+++....-.+++ =..|...+. T Consensus 105 ~~~c~~~~~~~~~~~~~s~~~~~~isi~R~~ai~ 138 (448) T 3AYN_A 105 FAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIG 138 (448) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567887776665544433333332 234544443 No 327 >6P9X_R Guanine nucleotide-binding protein G(s) subunit; GPCR, MEMBRANE PROTEIN;{Homo sapiens} Probab=69.60 E-value=0.58 Score=47.67 Aligned_cols=27 Identities=4% Similarity=0.007 Sum_probs=16.5 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKT 670 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~ 670 (908) ....|.+..++..++....+..+++-. T Consensus 177 ~~~~C~~~~~~~~~~~~~s~~~l~~ia 203 (427) T 6P9X_R 177 NVGWCRLVTAAYNYFHVTNFFWMFGEG 203 (427) T ss_dssp TCHHHHHHHHHHHHHHHHHHHHHTTTH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHH Confidence 457788877776655555555444443 No 328 >5X33_A LTB4 receptor,Lysozyme,LTB4 receptor (E.C.3.2.1.17); helix, MEMBRANE PROTEIN; HET: 7Y9; 3.7A {Cavia porcellus} Probab=69.09 E-value=0.61 Score=48.96 Aligned_cols=18 Identities=17% Similarity=0.259 Sum_probs=11.4 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+.+.. T Consensus 87 ~~~~C~~~~~~~~~~~~~ 104 (523) T 5X33_A 87 GLAGCRLCHYICGVSMYA 104 (523) T ss_pred chHHHHHHHHHHHHHHHH Confidence 367788877766554443 No 329 >5XSZ_A Lysophosphatidic acid receptor 6a,Endolysin,receptor (E.C.3.2.1.17); alpha helical, membrane protein; HET: OLC; 3.2A {Danio rerio} Probab=67.40 E-value=0.7 Score=47.60 Aligned_cols=34 Identities=15% Similarity=0.193 Sum_probs=17.1 Template_Neff=12.000 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA-LLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~-l~~K~~ri~~if 677 (908) ....|.+..++..+......-. ++.=..|.+.+. T Consensus 96 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidRy~ai~ 130 (477) T 5XSZ_A 96 GSLLCKLSVSLFYTNMYGSILFLTCISVDRFLAIV 130 (477) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3678888777665444332222 222334544444 No 330 >4PXZ_A P2Y purinoceptor 12, Soluble cytochrome; purinergic receptor P2Y12, agonist-bound, G-protein; HET: CLR, 6AD, OLC; 2.5A {Homo sapiens, Escherichia coli, Homo sapiens} Probab=67.15 E-value=0.71 Score=47.32 Aligned_cols=34 Identities=21% Similarity=0.307 Sum_probs=17.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ =..|.+.+. T Consensus 102 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 136 (466) T 4PXZ_A 102 RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTT 136 (466) T ss_dssp HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777665544433333333 233444443 No 331 >6IGK_A Endothelin receptor type B,Endolysin,Endothelin receptor; alpha helical, SIGNALING PROTEIN-PROTEIN BINDING; HET: CIT, OLC; 2.0A {Homo sapiens} Probab=65.67 E-value=0.8 Score=47.49 Aligned_cols=34 Identities=9% Similarity=0.173 Sum_probs=17.5 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+.+....-.++ .=..|.+.+. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidR~~ai~ 142 (498) T 6IGK_A 108 GAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVA 142 (498) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877766554443333332 2334544443 No 332 >3ODU_A C-X-C chemokine receptor type 4; Structural Genomics, PSI-2, Protein Structure; HET: OLC, OLA, ITD; 2.5A {Homo Sapiens, Enterobacteria phage T4} Probab=65.54 E-value=0.8 Score=47.55 Aligned_cols=34 Identities=18% Similarity=0.256 Sum_probs=18.7 Template_Neff=11.800 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|.+.+. T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidRy~~i~ 149 (502) T 3ODU_A 115 GNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIV 149 (502) T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 46789888877665544333333 33334554444 No 333 >5T04_A Neurotensin receptor type 1,Endolysin,NEUROTENSIN RECEPTOR; MEMBRANE PROTEIN, G PROTEIN-COUPLED RECEPTOR; HET: PEG, TCE; 3.3A {Rattus norvegicus} Probab=65.04 E-value=0.84 Score=47.61 Aligned_cols=16 Identities=6% Similarity=-0.145 Sum_probs=10.0 Template_Neff=11.700 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+.+. T Consensus 107 ~~~C~~~~~~~~~~~~ 122 (513) T 5T04_A 107 DAGCRGYYFLRDACTY 122 (513) T ss_pred hHHHHHHHHHHHHHHH Confidence 5678877666554443 No 334 >3ODU_B C-X-C chemokine receptor type 4; Structural Genomics, PSI-2, Protein Structure; HET: ITD, OLC, OLA; 2.5A {Homo Sapiens} Probab=65.04 E-value=0.84 Score=47.38 Aligned_cols=35 Identities=14% Similarity=0.200 Sum_probs=18.7 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if~ 678 (908) ....|.+..++..+++....- .++.=.-|.+.+.+ T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidR~~ai~~ 150 (502) T 3ODU_B 115 GNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVH 150 (502) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC Confidence 467888888776655443333 23333445554443 No 335 >3OE0_A C-X-C chemokine receptor type 4; Structural Genomics, PSI-2, Protein Structure; 2.9A {Homo Sapiens, Enterobacteria phage T4} Probab=61.92 E-value=1 Score=46.52 Aligned_cols=34 Identities=15% Similarity=0.206 Sum_probs=18.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA-LLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~-l~~K~~ri~~if 677 (908) ....|.+..++..+++....-. ++.=.-|.+.+. T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~l~~iaidRy~~i~ 149 (499) T 3OE0_A 115 GNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIV 149 (499) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3678888777766554433332 233334544444 No 336 >5T1A_A C-C chemokine receptor type 2; C-C Chemokine Receptor type 2; HET: SO4, 73R, VT5, YCM, OLC; 2.806A {Homo sapiens} Probab=60.86 E-value=1.1 Score=46.45 Aligned_cols=34 Identities=15% Similarity=0.207 Sum_probs=17.2 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=..|.+.+. T Consensus 119 ~~~~C~~~~~~~~~~~~~s~~~l~~iaidRy~~i~ 153 (508) T 5T1A_A 119 GNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIV 153 (508) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 36778887776654443333222 22334544444 No 337 >6K41_R Guanine nucleotide-binding protein G(o) subunit; GPCR, Complex, cryo-EM, MEMBRANE PROTEIN; HET: CZX; 2.9A {Homo sapiens} Probab=60.42 E-value=1.2 Score=46.60 Aligned_cols=34 Identities=15% Similarity=0.001 Sum_probs=15.1 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+....-.+++= .-|...+. T Consensus 280 ~~~~C~~~~~l~~~~~~~s~~~l~~iai~R~~ai~ 314 (512) T 6K41_R 280 RRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS 314 (512) T ss_dssp ----CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887777665544433333332 33444443 No 338 >6K42_R Guanine nucleotide-binding protein G(i) subunit; GPCR, Complex, cryo-EM, MEMBRANE PROTEIN; HET: CZX; 4.1A {Bos taurus} Probab=60.42 E-value=1.2 Score=46.60 Aligned_cols=34 Identities=15% Similarity=0.001 Sum_probs=17.5 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+....-.+++= .-|...+. T Consensus 280 ~~~~C~~~~~l~~~~~~~s~~~l~~iai~R~~ai~ 314 (512) T 6K42_R 280 RRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS 314 (512) T ss_dssp CSTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887777665544433333332 33444443 No 339 >5YC8_A Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome; GPCR crystallography, rationally thermostabilized mutant; HET: 3C0; 2.5A {Homo sapiens} Probab=60.13 E-value=1.2 Score=44.60 Aligned_cols=18 Identities=6% Similarity=0.071 Sum_probs=11.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 94 ~~~~C~~~~~~~~~~~~~ 111 (421) T 5YC8_A 94 GPVVCDLWLALDYVVSNA 111 (421) T ss_dssp CHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHH Confidence 367788877766554443 No 340 >6N4B_R Guanine nucleotide-binding protein G(i) subunit; Cannabinoid receptor, GPCR, synthetic cannabinoid; HET: KCA, CLR; 3.0A {Homo sapiens} Probab=59.77 E-value=1.2 Score=46.18 Aligned_cols=18 Identities=6% Similarity=0.296 Sum_probs=7.9 Template_Neff=10.800 Q NP_000836.2 587 PVFVAILGIIATTFVIVT 604 (908) Q Consensus 587 ~~~~~~~~i~~~~~~~~~ 604 (908) ..++.++|++.-++++.. T Consensus 138 ~~ii~iigi~~N~lvl~~ 155 (495) T 6N4B_R 138 SLTLGTFTVLENLLVLCV 155 (495) T ss_pred HHHHHHHHHHHHHHHHHH Confidence 344444555444443333 No 341 >3VW7_A Chimera of Proteinase-activated receptor 1; High resolution structure, protease-activated receptor; HET: OLC, VPX; 2.2A {Homo sapiens, Enterobacteria phage T4, Homo sapiens} Probab=59.50 E-value=1.2 Score=45.59 Aligned_cols=34 Identities=15% Similarity=0.224 Sum_probs=17.4 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.+++ =.-|.+.+. T Consensus 89 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidRy~ai~ 123 (484) T 3VW7_A 89 GSELCRFVTAAFYCNMYASILLMTVISIDRFLAVV 123 (484) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567888777765544433333332 233444443 No 342 >6GPS_A C-C chemokine receptor type 2,Rubredoxin,C-C; GPCR, Signalling, Drug-design, SIGNALING PROTEIN; HET: F7N; 3.3A {Homo sapiens} Probab=59.46 E-value=1.2 Score=44.63 Aligned_cols=23 Identities=9% Similarity=0.160 Sum_probs=13.4 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL 666 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l 666 (908) ....|.+..++..+++....-.+ T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~ 130 (429) T 6GPS_A 108 GNAMCKLFTGLYHIGYFGGIFFI 130 (429) T ss_pred hHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887776665544433333 No 343 >6ME8_A Soluble cytochrome b562,Melatonin receptor type; GPCR, melatonin receptor type 1B; HET: JEY; 3.1A {Escherichia coli} Probab=58.95 E-value=1.3 Score=45.24 Aligned_cols=26 Identities=15% Similarity=0.132 Sum_probs=15.9 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK 669 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K 669 (908) ....|.+..++..+++...+-.+++- T Consensus 185 ~~~~C~~~~~~~~~~~~~s~~~~~~i 210 (460) T 6ME8_A 185 GEEHCKASAFVMGLSVIGSVWNITAI 210 (460) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHH Confidence 36778888777766555444444443 No 344 >6ME6_A Soluble cytochrome b562,Melatonin receptor type; GPCR, melatonin receptor type 1B; HET: OLC, JEY; 2.8A {Escherichia coli} Probab=58.34 E-value=1.3 Score=45.13 Aligned_cols=34 Identities=18% Similarity=0.168 Sum_probs=17.1 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -.-|...+. T Consensus 185 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 219 (460) T 6ME6_A 185 GEEHCKASAFVMGLSVIGSVWNITAIAIDRYLYIC 219 (460) T ss_dssp CSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3667888777665544433333322 233444443 No 345 >4GRV_A Neurotensin receptor type 1, Neurotensin; G-protein coupled receptor, neurotensin receptor; HET: EPE; 2.802A {Rattus norvegicus, Enterobacteria phage T4} Probab=58.13 E-value=1.4 Score=45.79 Aligned_cols=33 Identities=9% Similarity=-0.115 Sum_probs=16.5 Template_Neff=11.800 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAA-LLTKTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~-l~~K~~ri~~if 677 (908) ...|.+..++..+++....-. ++.=..|.+.+. T Consensus 107 ~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~ai~ 140 (510) T 4GRV_A 107 DAGCRGYYFLRDACTYATALNVASLSVARYLAIC 140 (510) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 567887776655444333222 233344554444 No 346 >6WWZ_R Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit; GPCR, Chemokine, Chemokine receptor, Complex; 3.34A {Rattus norvegicus} Probab=57.89 E-value=1.4 Score=46.26 Aligned_cols=33 Identities=12% Similarity=0.192 Sum_probs=17.1 Template_Neff=10.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~i 676 (908) ....|.+..++..+++...+-.++.- ..|...+ T Consensus 259 ~~~~C~~~~~~~~~~~~~s~~~l~~iaidRy~ai 292 (529) T 6WWZ_R 259 SNATCKLLKGIYAINFNCGMLLLTCISMDRYIAI 292 (529) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887777665554433333332 2344444 No 347 >5ZKC_A Muscarinic acetylcholine receptor M2,Apo-cytochrome b562; GPCR crystallography, rationally thermostabilized mutant; HET: 3C0; 2.3A {Homo sapiens} Probab=57.52 E-value=1.4 Score=43.99 Aligned_cols=34 Identities=12% Similarity=0.115 Sum_probs=17.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ =.-|...+. T Consensus 94 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 128 (421) T 5ZKC_A 94 GPVVCDLWLALDYVVSNARVMNLLIISFDRYFCVT 128 (421) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 3678888877665554433333322 233444443 No 348 >5IU7_A Adenosine receptor A2a,Soluble cytochrome b562,Adenosine; G-protein-coupled receptor, integral membrane protein; HET: CLR, OLC, OLA, 6DY, OLB; 1.9A {Homo sapiens} Probab=57.19 E-value=1.4 Score=44.21 Aligned_cols=17 Identities=18% Similarity=0.092 Sum_probs=10.0 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 82 ~~~~C~~~~~~~~~~~~ 98 (433) T 5IU7_A 82 ACHGCLFIACFVLVLAQ 98 (433) T ss_pred cchHHHHHHHHHHHHHH Confidence 35567777766554443 No 349 >5NM4_A Lysozyme C (E.C.3.2.1.17); room-temperature, serial crystallography, Signaling protein; HET: ZMA, OLA, CLR; 1.7A {Homo sapiens} Probab=57.15 E-value=1.4 Score=44.20 Aligned_cols=17 Identities=18% Similarity=0.092 Sum_probs=10.0 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 82 ~~~~C~~~~~~~~~~~~ 98 (433) T 5NM4_A 82 ACHGCLFIACFVLVLAQ 98 (433) T ss_dssp EHHHHHHHHHHHHHHHH T ss_pred ccchHHHHHHHHHHHHH Confidence 35567777666554443 No 350 >5WIU_A D(4) dopamine receptor,Soluble cytochrome b562; GPCR, dopamine receptor, antagonist, sodium; HET: PEG, PO4, OLA, AQD; 1.962A {Homo sapiens} Probab=56.40 E-value=1.5 Score=43.87 Aligned_cols=22 Identities=9% Similarity=-0.076 Sum_probs=13.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+.+....-. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~ 129 (422) T 5WIU_A 108 SPRLCDALMAMDVMLCTASIFN 129 (422) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHH Confidence 3567888777765544433333 No 351 >5WIV_A D(4) dopamine receptor,Soluble cytochrome b562; GPCR, dopamine receptor, antagonist, sodium; HET: PEG, PO4, OLA, AQD; 2.143A {Homo sapiens} Probab=56.40 E-value=1.5 Score=43.87 Aligned_cols=22 Identities=9% Similarity=-0.076 Sum_probs=13.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+.+....-. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~ 129 (422) T 5WIV_A 108 SPRLCDALMAMDVMLCTASIFN 129 (422) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHHHHH Confidence 3567888777765544433333 No 352 >5NDD_A Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated; MEMBRANE PROTEIN, GPCR, 7TM; HET: 8TZ; 2.801A {Enterobacteria phage T4} Probab=56.28 E-value=1.5 Score=46.94 Aligned_cols=34 Identities=21% Similarity=0.221 Sum_probs=17.2 Template_Neff=11.000 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.+++ =.-|...+. T Consensus 273 ~~~~C~~~~~l~~~~~~~s~~~l~~iaidRy~aI~ 307 (619) T 5NDD_A 273 GEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIV 307 (619) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777665544433333333 233444443 No 353 >4IB4_A Human 5-HT2B receptor_BRIL chimera; ergotamine, Novel protein engineering, GPCR; HET: CLR, PLM, OLA, ERM, PEG, OLC, OLB; 2.7A {Homo sapiens} Probab=56.21 E-value=1.5 Score=43.85 Aligned_cols=34 Identities=18% Similarity=0.037 Sum_probs=17.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -.-|...+. T Consensus 99 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 133 (430) T 4IB4_A 99 PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIK 133 (430) T ss_dssp CTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567888777765554433333333 233444443 No 354 >6AK3_A Prostaglandin E2 receptor EP3 subtype,Soluble; GPCR, lipid, signaling protein, prostanoid; HET: POV, P2E; 2.9A {Homo sapiens} Probab=55.29 E-value=1.6 Score=43.47 Aligned_cols=19 Identities=16% Similarity=0.140 Sum_probs=11.2 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+.+... T Consensus 88 ~~~~c~~~~~~~~~~~~~s 106 (418) T 6AK3_A 88 SGRLCTFFGLTMTVFGLSS 106 (418) T ss_dssp GGHHHHHHHHHHHHHHHHH T ss_pred CchhHHHHHHHHHHHHHHH Confidence 3467887776665444433 No 355 >6AK3_B Prostaglandin E2 receptor EP3 subtype,Soluble; GPCR, lipid, signaling protein, prostanoid; HET: P2E, POV; 2.9A {Homo sapiens} Probab=55.29 E-value=1.6 Score=43.47 Aligned_cols=19 Identities=16% Similarity=0.140 Sum_probs=10.8 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+.+... T Consensus 88 ~~~~c~~~~~~~~~~~~~s 106 (418) T 6AK3_B 88 SGRLCTFFGLTMTVFGLSS 106 (418) T ss_dssp -CHHHHHHHHHHHHHHHHH T ss_pred CchhHHHHHHHHHHHHHHH Confidence 3467887776665444433 No 356 >6M9T_A Prostaglandin E2 receptor EP3 subtype,Endolysin; GPCR, prostaglandin E2 receptor 3; HET: SO4, OLA, J9P, OLC; 2.5A {Homo sapiens} Probab=54.94 E-value=1.7 Score=45.58 Aligned_cols=17 Identities=12% Similarity=0.104 Sum_probs=10.2 Template_Neff=11.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCF 661 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l 661 (908) ...|.+..++..+++.. T Consensus 139 ~~~C~~~~~~~~~~~~~ 155 (537) T 6M9T_A 139 GRLCTFFGLTMTVFGLS 155 (537) T ss_pred hhHHHHHHHHHHHHHHH Confidence 46777777665544443 No 357 >5ZKP_A Platelet-activating factor receptor,Flavodoxin; G protein-coupled receptor, Platelet-activating factor; HET: 9ER, FMN; 2.81A {Homo sapiens} Probab=54.81 E-value=1.7 Score=44.22 Aligned_cols=34 Identities=18% Similarity=0.216 Sum_probs=16.9 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+......-.++ .=.-|.+.+. T Consensus 88 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 122 (466) T 5ZKP_A 88 PKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVT 122 (466) T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877765544433333322 2334444444 No 358 >5ZKQ_A Platelet-activating factor receptor; G protein-coupled receptor, Platelet-activating factor; HET: SO4, 9EU, OLC; 2.9A {Homo sapiens} Probab=54.65 E-value=1.7 Score=43.68 Aligned_cols=18 Identities=6% Similarity=0.264 Sum_probs=11.5 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 88 ~~~~C~~~~~~~~~~~~~ 105 (438) T 5ZKQ_A 88 PKFLCNVAGCLFFINTYC 105 (438) T ss_dssp CHHHHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHH Confidence 367788887766554443 No 359 >5W0P_C T4 lysozyme-human rhodopsin-mouse visual arrestin; rhodopsin, GPCR, arrestin, GRK, phosphorylation; HET: TPO, SEP, NAG; 3.013A {Enterobacteria phage RB55} Probab=54.43 E-value=1.7 Score=49.17 Aligned_cols=21 Identities=19% Similarity=0.278 Sum_probs=12.4 Template_Neff=10.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA 664 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~ 664 (908) ....|.+..++..+.+...+- T Consensus 266 ~~~~C~~~~~l~~~~~~~s~~ 286 (906) T 5W0P_C 266 GPTGCNLQGFFATLGGEIALW 286 (906) T ss_pred CchHHHHHHHHHHHHHHHHHH Confidence 356788877766554443333 No 360 >5W0P_B T4 lysozyme-human rhodopsin-mouse visual arrestin; rhodopsin, GPCR, arrestin, GRK, phosphorylation; HET: SEP, NAG, TPO; 3.013A {Enterobacteria phage RB55} Probab=54.02 E-value=1.8 Score=49.07 Aligned_cols=23 Identities=22% Similarity=0.327 Sum_probs=13.4 Template_Neff=10.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL 666 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l 666 (908) ....|.+..++..+.+...+-.+ T Consensus 266 ~~~~C~~~~~l~~~~~~~s~~~l 288 (906) T 5W0P_B 266 GPTGCNLQGFFATLGGEIALWSL 288 (906) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHHHHHH Confidence 35678887776665544433333 No 361 >6OSA_R Neurotensin receptor type 1, JMV449; GPCR, G-protein, complex, SIGNALING PROTEIN;{Homo sapiens} Probab=53.46 E-value=1.8 Score=43.48 Aligned_cols=16 Identities=6% Similarity=-0.145 Sum_probs=9.8 Template_Neff=12.000 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+++. T Consensus 158 ~~~c~~~~~~~~~~~~ 173 (435) T 6OSA_R 158 DAGCRGYYFLRDACTY 173 (435) T ss_pred HHHHHHHHHHHHHHHH Confidence 5678777666554443 No 362 >4U14_A Muscarinic acetylcholine receptor M3,Endolysin fusion; alpha helix, G protein-coupled receptors; HET: 0HK; 3.57A {Rattus norvegicus} Probab=52.86 E-value=1.9 Score=43.86 Aligned_cols=22 Identities=9% Similarity=0.028 Sum_probs=12.9 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..++.....-. T Consensus 81 ~~~~C~~~~~~~~~~~~~s~~~ 102 (460) T 4U14_A 81 GNLACDLWLSIDYVASNASVMN 102 (460) T ss_dssp HHHHHHHHHHHHHHHHHHHHHH T ss_pred CccHHHHHHHHHHHHHHHHHHH Confidence 3677888777666554433333 No 363 >5TUD_A Chimera protein of 5-hydroxytryptamine receptor; 7-TM, GPCR, Fab, complex, SIGNALING; HET: ERM; 3.0A {Homo sapiens} Probab=52.52 E-value=1.9 Score=43.67 Aligned_cols=34 Identities=18% Similarity=0.025 Sum_probs=17.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+......-.++ .=.-|...+. T Consensus 115 ~~~~C~~~~~~~~~~~~~s~~~~~~iaidR~~~i~ 149 (457) T 5TUD_A 115 PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIK 149 (457) T ss_dssp CTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877766544433333322 2334444443 No 364 >6C1R_B C5a anaphylatoxin chemotactic receptor 1; GPCR, MEMBRANE PROTEIN-INHIBITOR complex; HET: OLA, MLI, ZAL, EFD, OLC, YCM; 2.2A {Escherichia coli} Probab=52.18 E-value=2 Score=43.13 Aligned_cols=34 Identities=26% Similarity=0.328 Sum_probs=17.0 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -..|...+. T Consensus 191 ~~~~C~~~~~~~~~~~~~s~~~~~~is~~R~~~i~ 225 (422) T 6C1R_B 191 GGAACSILPSLILLNMYASILLLATISADRFLLVF 225 (422) T ss_dssp CHHHHHHGGGHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567887777665544433333333 233444443 No 365 >6OL9_A Muscarinic acetylcholine receptor M5, T4; GPCR inhibitor complex, MEMBRANE PROTEIN; HET: P33, 0HK, OLA, OLC; 2.541A {Homo sapiens} Probab=52.11 E-value=2 Score=44.03 Aligned_cols=16 Identities=6% Similarity=0.185 Sum_probs=10.0 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGM 659 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf 659 (908) ....|.+..++..++. T Consensus 81 ~~~~C~~~~~~~~~~~ 96 (480) T 6OL9_A 81 GSLACDLWLALDYVAS 96 (480) T ss_dssp CHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHH Confidence 3567887776655444 No 366 >6LI0_A G-protein coupled receptor 52,Flavodoxin,G-protein coupled; Human GPR52 receptor, Class A; HET: FMN, FLC, OLC, EN6, PEG; 2.2A {Homo sapiens} Probab=52.05 E-value=2 Score=43.78 Aligned_cols=34 Identities=15% Similarity=0.198 Sum_probs=17.0 Template_Neff=11.800 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+.+....-.++ .=.-|.+.+. T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 129 (468) T 6LI0_A 95 ESLTCQVFGYIISVLKSVSMWCLACISVDRYLAIT 129 (468) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 466788877765544433333332 2333444443 No 367 >4XES_A neurotensin receptor subtype 1, lysozyme; membrane protein, G protein-coupled receptor; HET: PEG, GOL, CIT, EPE; 2.6A {Rattus norvegicus} Probab=51.22 E-value=2.1 Score=44.65 Aligned_cols=33 Identities=9% Similarity=-0.048 Sum_probs=16.5 Template_Neff=11.800 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+.+....-.+++ -.-|...+. T Consensus 107 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 140 (541) T 4XES_A 107 DAGCRGYYFLRDACTYATALNVASLSVARYLAIC 140 (541) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 567887776665544433333332 233444443 No 368 >6C1Q_B C5a anaphylatoxin chemotactic receptor 1; GPCR, MEMBRANE PROTEIN; HET: 9P2, YCM, ZAL; 2.9A {Escherichia coli} Probab=50.95 E-value=2.1 Score=42.87 Aligned_cols=34 Identities=26% Similarity=0.328 Sum_probs=16.9 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.+++ -..|...+. T Consensus 191 ~~~~C~~~~~~~~~~~~~s~~~~~~is~~R~~~i~ 225 (422) T 6C1Q_B 191 GGAACSILPSLILLNMYASILLLATISADRFLLVF 225 (422) T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 3567887777665544433333333 233444443 No 369 >3V2Y_A Sphingosine 1-phosphate receptor 1, Lysozyme; sphingosine, EDG receptor, lipid receptor; HET: NAG, ML5; 2.8A {Homo sapiens, Enterobacteria phage T4} Probab=50.54 E-value=2.2 Score=44.40 Aligned_cols=33 Identities=15% Similarity=0.082 Sum_probs=16.0 Template_Neff=11.000 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ...|.+..++..++.....-.+++= .-|.+.+. T Consensus 132 ~~~c~~~~~~~~~~~~~s~~~l~~iaidRy~aI~ 165 (520) T 3V2Y_A 132 PAQWFLREGSMFVALSASVFSLLAIAIERYITML 165 (520) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4678777766554444333333332 23444443 No 370 >5UIW_A C-C chemokine receptor type 5,Rubredoxin,C-C; G-protein coupled receptor, Chemokine receptor; HET: OLC, OLA; 2.204A {Homo sapiens} Probab=50.33 E-value=2.2 Score=42.19 Aligned_cols=19 Identities=11% Similarity=0.266 Sum_probs=11.5 Template_Neff=12.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+++... T Consensus 99 ~~~~c~~~~~~~~~~~~~s 117 (411) T 5UIW_A 99 GNTMCQLLTGLYFIGFFSG 117 (411) T ss_dssp HHHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHHH Confidence 3567887777665544433 No 371 >5OLZ_A Adenosine receptor A2a,Soluble cytochrome b562,Adenosine; G-Protein Coupled Receptor, Adenosine 2a; HET: TAR, CLR, OLA, T4E, OLC, PGE; 1.9A {Homo sapiens} Probab=49.96 E-value=2.3 Score=42.63 Aligned_cols=16 Identities=19% Similarity=0.104 Sum_probs=9.3 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+... T Consensus 84 ~~~C~~~~~~~~~~~~ 99 (434) T 5OLZ_A 84 CHGCLFIACFVLVLAQ 99 (434) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHH Confidence 5567776666554433 No 372 >6P9Y_R Guanine nucleotide-binding protein G(s) subunit; GPCR, MEMBRANE PROTEIN;{Homo sapiens} Probab=49.66 E-value=2.3 Score=43.79 Aligned_cols=30 Identities=20% Similarity=0.252 Sum_probs=18.4 Template_Neff=9.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIH 674 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~ 674 (908) ...|.+..++...+....+..+++-.+-.+ T Consensus 219 ~~~C~~~~~~~~~~~~~s~~wl~~iai~ry 248 (483) T 6P9Y_R 219 TVECKAVMVFFHYCVVSNYFWLFIEGLYLF 248 (483) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 578888877766665555555555444333 No 373 >6MXT_A Fusion protein of Lysozyme and; G protein-coupled receptor, adrenergic receptor; HET: OLA, K5Y, OLC, P33, HTO, YCM; 2.95934213525A {Enterobacteria phage T4} Probab=49.35 E-value=2.4 Score=43.36 Aligned_cols=34 Identities=21% Similarity=0.215 Sum_probs=16.6 Template_Neff=11.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++....+-.+++ =.-|...+. T Consensus 237 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 271 (472) T 6MXT_A 237 GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT 271 (472) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567877776655444333333322 234444443 No 374 >6KUX_A alpha2A adrenergic receptor; alpha2A adrenergic receptor, antagonist, GPCR; HET: E3F, PEG, FLC; 2.7A {Spodoptera frugiperda} Probab=48.92 E-value=2.4 Score=41.68 Aligned_cols=18 Identities=11% Similarity=-0.077 Sum_probs=11.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 83 ~~~~C~~~~~~~~~~~~~ 100 (395) T 6KUX_A 83 GKAWCEIYLALDVLFCTS 100 (395) T ss_dssp SHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHH Confidence 356788877766554443 No 375 >4U15_B M3-mT4L, Tiotropium; GPCR T4L Stabillized Crystallography, MEMBRANE; HET: OLC, TAR, 0HK, P6G; 2.8A {Rattus norvegicus} Probab=48.41 E-value=2.5 Score=42.07 Aligned_cols=18 Identities=6% Similarity=0.032 Sum_probs=11.3 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 81 ~~~~C~~~~~~~~~~~~~ 98 (418) T 4U15_B 81 GNLACDLWLSIDYVASNA 98 (418) T ss_dssp CSHHHHHHHHHHHHHHHH T ss_pred cccHHHHHHHHHHHHHHH Confidence 367788877766554443 No 376 >3EML_A Human Adenosine A2A receptor/T4 lysozyme; adenosine, caffeine, GPCR, membrane protein; HET: STE, ZMA, SO4; 2.6A {Homo sapiens, Enterobacteria phage T4, Homo sapiens} Probab=48.34 E-value=2.5 Score=43.30 Aligned_cols=15 Identities=20% Similarity=0.173 Sum_probs=9.0 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLG 658 (908) Q Consensus 644 ~~~~C~~~~~~~~~g 658 (908) ....|.+..++..+. T Consensus 88 ~~~~C~~~~~l~~~~ 102 (488) T 3EML_A 88 ACHGCLFIACFVLVL 102 (488) T ss_dssp CHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHH Confidence 356677776665443 No 377 >6ORV_RP Guanine nucleotide-binding protein G(s) subunit; G-coupled protein receptor, GPCR, non-peptide; HET: N2V; 3.0A {Homo sapiens} Probab=48.20 E-value=2.5 Score=43.60 Aligned_cols=34 Identities=15% Similarity=0.304 Sum_probs=20.6 Template_Neff=9.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++........+.-+++-.+-+|... T Consensus 231 ~~~~C~~~~~~~~~~~~as~~wl~~~al~l~~~i 264 (491) T 6ORV_RP 231 DSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLL 264 (491) T ss_pred CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3578888877766666555555555554444433 No 378 >3PBL_A D(3) dopamine receptor; Structural Genomics, PSI-2, PSI-Biology, Protein; HET: ETQ, MAL; 2.89A {Homo sapiens, Enterobacteria phage T4} Probab=47.84 E-value=2.6 Score=43.15 Aligned_cols=33 Identities=15% Similarity=0.089 Sum_probs=16.5 Template_Neff=11.500 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+......-.+++ =.-|.+.+. T Consensus 109 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 142 (481) T 3PBL_A 109 RICCDVFVTLDVMMCTASIWNLCAISIDRYTAVV 142 (481) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567887776655444333333322 334444443 No 379 >6CMO_R Soluble cytochrome b562,Rhodopsin, Guanine nucleotide-binding; Rhodopsin G protein ; HET: NAG;{Escherichia coli} Probab=47.51 E-value=2.6 Score=42.94 Aligned_cols=34 Identities=18% Similarity=0.261 Sum_probs=17.3 Template_Neff=10.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.++. -.-|...+. T Consensus 246 ~~~~C~~~~~l~~~~~~~s~~~~~~isi~R~~ai~ 280 (463) T 6CMO_R 246 GPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVC 280 (463) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CCchHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567888777666554433333332 233444443 No 380 >6B3J_R Guanine nucleotide-binding protein G(s) subunit; class B G protein-coupled receptor;{Homo sapiens} Probab=46.45 E-value=2.8 Score=43.23 Aligned_cols=34 Identities=15% Similarity=0.304 Sum_probs=20.6 Template_Neff=9.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++........+.-+++-.+-+|+.. T Consensus 231 ~~~~C~~~~~~~~~~~las~~wl~~~al~l~~~i 264 (491) T 6B3J_R 231 DSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLL 264 (491) T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3578888877766666555555555554444433 No 381 >4LDE_A Lysozyme, Beta-2 adrenergic receptor (E.C.3.2.1.17); G protein coupled receptor, MEMBRANE; HET: P0G, 1WV; 2.79A {Enterobacteria phage T4, Homo sapiens} Probab=45.08 E-value=3 Score=42.41 Aligned_cols=33 Identities=21% Similarity=0.226 Sum_probs=16.8 Template_Neff=11.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~i 676 (908) ....|.+..++....+...+-.+++- ..|...+ T Consensus 251 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i 284 (469) T 4LDE_A 251 GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAI 284 (469) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678877776655544333333332 3344443 No 382 >5WF5_A Human A2a adenosine receptor_T4L chimera; human A2a adenosine receptor, D52N; HET: OLC, UKA; 2.6A {Homo sapiens} Probab=44.86 E-value=3.1 Score=42.97 Aligned_cols=13 Identities=23% Similarity=0.319 Sum_probs=7.7 Template_Neff=10.900 Q NP_000836.2 645 TIICSFRRVFLGL 657 (908) Q Consensus 645 ~~~C~~~~~~~~~ 657 (908) ...|.+..++..+ T Consensus 105 ~~~C~~~~~l~~~ 117 (504) T 5WF5_A 105 CHGCLFIACFVLV 117 (504) T ss_dssp HHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHH Confidence 4567776665443 No 383 >2R4R_A Beta-2 adrenergic receptor, antibody for; transmembrane helix, G-protein coupled receptor; 3.4A {Mus musculus} Probab=44.84 E-value=3.1 Score=40.08 Aligned_cols=17 Identities=18% Similarity=0.247 Sum_probs=10.5 Template_Neff=12.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 102 ~~~~c~~~~~~~~~~~~ 118 (365) T 2R4R_A 102 GNFWCEFWTSIDVLCVT 118 (365) T ss_pred hhHHHHHHHHHHHHHHH Confidence 35678777766554443 No 384 >5TGZ_A Cannabinoid receptor 1,Flavodoxin; Membrane protein, G protein-coupled receptor; HET: OLC, OLA, ZDG, FMN; 2.8A {Homo sapiens} Probab=44.78 E-value=3.1 Score=42.00 Aligned_cols=20 Identities=10% Similarity=0.353 Sum_probs=9.1 Template_Neff=11.700 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVT 604 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~ 604 (908) ++..++.++|++.-++++.. T Consensus 27 ~~~~~~~~~gi~~N~~vl~~ 46 (452) T 5TGZ_A 27 VLSLTLGTFTVLENLLVLCV 46 (452) T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 33444455555544444433 No 385 >3RZE_A Histamine H1 receptor/Lysozyme chimera; Structural Genomics, PSI-Biology, Membrane Protein; HET: PO4, D7V, 5EH, OLC; 3.1A {Homo sapiens, Enterobacteria phage T4} Probab=44.72 E-value=3.1 Score=42.02 Aligned_cols=18 Identities=11% Similarity=0.065 Sum_probs=11.4 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 77 ~~~~C~~~~~l~~~~~~~ 94 (452) T 3RZE_A 77 GRPLCLFWLSMDYVASTA 94 (452) T ss_dssp HHHHHHHHHHHHHHHHHH T ss_pred CCcHHHHHHHHHHHHHHH Confidence 467888877766544433 No 386 >6MEO_B Envelope glycoprotein gp160, T-cell surface; HIV coreceptor, MEMBRANE PROTEIN; HET: NAG, TYS, MAN, A2G, BMA; 3.9A {Human immunodeficiency virus 1} Probab=44.70 E-value=3.1 Score=39.05 Aligned_cols=18 Identities=11% Similarity=0.274 Sum_probs=10.9 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|....++...++.. T Consensus 97 ~~~~c~~~~~~~~~~~~~ 114 (313) T 6MEO_B 97 GNTMCQLLTGLYFIGFFS 114 (313) T ss_pred cHHHHHHHHHHHHHHHHH Confidence 356788777665554443 No 387 >4ZUD_A Chimera protein of Soluble cytochrome; human Angiotensin Receptor AT1R, BRIL; HET: OLM; 2.8A {Escherichia coli} Probab=44.48 E-value=3.1 Score=41.07 Aligned_cols=22 Identities=9% Similarity=0.214 Sum_probs=12.9 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+++....-. T Consensus 192 ~~~~c~~~~~~~~~~~~~s~~~ 213 (410) T 4ZUD_A 192 GNYLCKIASASVSFNLYASVFL 213 (410) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777666554433333 No 388 >4IAR_A Chimera protein of human 5-hydroxytryptamine; ergotamine, Novel protein engineering, GPCR; HET: OLB, ERM; 2.7A {Homo sapiens, Escherichia coli} Probab=44.43 E-value=3.2 Score=40.86 Aligned_cols=17 Identities=12% Similarity=0.091 Sum_probs=10.8 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 89 ~~~~C~~~~~~~~~~~~ 105 (401) T 4IAR_A 89 GQVVCDFWLSSDITCCT 105 (401) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHH Confidence 36778887776554443 No 389 >6D26_A Prostaglandin D2 receptor 2, Endolysin; GPCR, MEMBRANE PROTEIN-ANTAGONIST complex; HET: PGE, SIN, OLA, SO4, FSY, YCM; 2.798A {Homo sapiens} Probab=44.14 E-value=3.2 Score=42.01 Aligned_cols=33 Identities=21% Similarity=0.243 Sum_probs=17.1 Template_Neff=12.100 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+......-.+++ =..|.+.+. T Consensus 102 ~~~C~~~~~~~~~~~~~s~~~~~~ia~~Ry~ai~ 135 (470) T 6D26_A 102 TTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVV 135 (470) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567888777665544433333333 334544444 No 390 >6D27_A Prostaglandin D2 receptor 2, Endolysin; GPCR, MEMBRANE PROTEIN-ANTAGONIST complex; HET: MES, PGE, OLA, FT4, SO4, YCM, PGO; 2.738A {Homo sapiens} Probab=44.14 E-value=3.2 Score=42.01 Aligned_cols=33 Identities=21% Similarity=0.243 Sum_probs=17.1 Template_Neff=12.100 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ...|.+..++..+......-.+++ =..|.+.+. T Consensus 102 ~~~C~~~~~~~~~~~~~s~~~~~~ia~~Ry~ai~ 135 (470) T 6D27_A 102 TTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVV 135 (470) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 567888777665544433333333 334544444 No 391 >6A93_A 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562; MEMBRANE PROTEIN; HET: CLR, PLM, 1PE, 8NU; 3.0A {Homo sapiens} Probab=43.83 E-value=3.3 Score=40.22 Aligned_cols=18 Identities=11% Similarity=-0.027 Sum_probs=11.3 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 78 ~~~~C~~~~~~~~~~~~~ 95 (376) T 6A93_A 78 PSKLCAVWIYLDVLFSTA 95 (376) T ss_dssp CHHHHHHHHHHHHHHHHH T ss_pred ChhHHHHHHHHHHHHHHH Confidence 356788877766544443 No 392 >6A94_A 5-hydroxytryptamine receptor 2A,Human Serotonin Receptor; receptor, MEMBRANE PROTEIN; HET: PLM, 1PE, ZOT, CLR, A6L; 2.9A {Homo sapiens} Probab=43.83 E-value=3.3 Score=40.22 Aligned_cols=18 Identities=11% Similarity=-0.027 Sum_probs=11.3 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 78 ~~~~C~~~~~~~~~~~~~ 95 (376) T 6A94_A 78 PSKLCAVWIYLDVLFSTA 95 (376) T ss_dssp CTHHHHHHHHHHHHHHHH T ss_pred ChhHHHHHHHHHHHHHHH Confidence 356788877766544443 No 393 >4IAQ_A 5-hydroxytryptamine receptor 1B; dihydroergotamine, Novel protein engineering, GPCR; HET: 2GM; 2.8A {Homo sapiens, Escherichia coli} Probab=43.20 E-value=3.4 Score=40.64 Aligned_cols=18 Identities=11% Similarity=0.043 Sum_probs=11.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..++... T Consensus 89 ~~~~C~~~~~~~~~~~~~ 106 (403) T 4IAQ_A 89 GQVVCDFWLSSDITCCTA 106 (403) T ss_dssp HHHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHH Confidence 356788877766554443 No 394 >6KPG_R Guanine nucleotide-binding protein G(i) subunit; GPCR, G protein, cryo-EM, MEMBRANE; HET: 8D0;{Homo sapiens} Probab=42.85 E-value=3.5 Score=41.88 Aligned_cols=18 Identities=6% Similarity=0.329 Sum_probs=8.0 Template_Neff=11.600 Q NP_000836.2 586 VPVFVAILGIIATTFVIV 603 (908) Q Consensus 586 ~~~~~~~~~i~~~~~~~~ 603 (908) +..+++++|++..++++. T Consensus 166 ~~~~~~~~gi~~N~l~i~ 183 (469) T 6KPG_R 166 LSLTLGTFTVLENLLVLC 183 (469) T ss_dssp HHHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHHhHHHHH Confidence 334444555544444333 No 395 >4MQS_A Muscarinic acetylcholine receptor M2, Nanobody; G protein-coupled receptor, Muscarinic acetylcholine; HET: IXO; 3.5A {Homo sapiens} Probab=42.44 E-value=3.5 Score=39.35 Aligned_cols=18 Identities=6% Similarity=0.071 Sum_probs=11.0 Template_Neff=12.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 109 ~~~~c~~~~~~~~~~~~~ 126 (351) T 4MQS_A 109 GPVVCDLWLALDYVVSNA 126 (351) T ss_pred ChhHHHHHHHHHHHHHHH Confidence 356787777665554443 No 396 >4DJH_B Kappa-type opioid receptor; JDtic, GPCR newtork, PSI-Biology, KOR; HET: JDC, OLC, CIT, PEG; 2.9A {Homo Sapiens} Probab=42.33 E-value=3.6 Score=41.85 Aligned_cols=19 Identities=16% Similarity=0.183 Sum_probs=11.6 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFS 662 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~ 662 (908) ....|.+..++..+++... T Consensus 90 ~~~~C~~~~~~~~~~~~~s 108 (480) T 4DJH_B 90 GDVLCKIVLSIDYYNMFTS 108 (480) T ss_dssp HHHHHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHHHH Confidence 3567888777655544433 No 397 >6OS0_A Type-1 angiotensin II receptor,Soluble cytochrome; GPCR, nanobody, MEMBRANE PROTEIN; HET: NAG; 2.9A {Homo sapiens} Probab=42.32 E-value=3.6 Score=40.84 Aligned_cols=34 Identities=15% Similarity=0.222 Sum_probs=17.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|...+. T Consensus 104 ~~~~C~~~~~~~~~~~~~s~~~~~~isi~R~~~i~ 138 (425) T 6OS0_A 104 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIV 138 (425) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778887776655443333322 22334444443 No 398 >6OS1_A Type-1 angiotensin II receptor,Soluble cytochrome; GPCR, MEMBRANE PROTEIN; HET: CLR, OLC; 2.794A {Homo sapiens} Probab=42.32 E-value=3.6 Score=40.84 Aligned_cols=34 Identities=15% Similarity=0.222 Sum_probs=17.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|...+. T Consensus 104 ~~~~C~~~~~~~~~~~~~s~~~~~~isi~R~~~i~ 138 (425) T 6OS1_A 104 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIV 138 (425) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778887776655443333322 22334444443 No 399 >6OS2_A Type-1 angiotensin II receptor,Soluble cytochrome; GPCR, MEMBRANE PROTEIN; HET: CLR, OLC, NAG; 2.7A {Homo sapiens} Probab=42.32 E-value=3.6 Score=40.84 Aligned_cols=34 Identities=15% Similarity=0.222 Sum_probs=17.3 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAAL-LTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l-~~K~~ri~~if 677 (908) ....|.+..++..+++....-.+ +.=.-|...+. T Consensus 104 ~~~~C~~~~~~~~~~~~~s~~~~~~isi~R~~~i~ 138 (425) T 6OS2_A 104 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIV 138 (425) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778887776655443333322 22334444443 No 400 >4YAY_A human Angiotensin Receptor_Bril Chimera; XFEL, Serial Femtosecond Crystallography, human; HET: ZD7; 2.9A {Escherichia coli} Probab=41.90 E-value=3.7 Score=40.60 Aligned_cols=25 Identities=12% Similarity=0.218 Sum_probs=14.7 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+++...+..++. T Consensus 192 ~~~~c~~~~~~~~~~~~~s~~~~~~ 216 (414) T 4YAY_A 192 GNYLCKIASASVSFNLYASVFLLTC 216 (414) T ss_dssp TTHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777766555444444433 No 401 >4N6H_A Soluble cytochrome b562, Delta-type opioid; human opioid receptor, sodium regulation; HET: OLA, PGE, TLA, OLC, EJ4; 1.8A {Escherichia coli, Homo sapiens} Probab=41.57 E-value=3.7 Score=40.64 Aligned_cols=34 Identities=15% Similarity=0.121 Sum_probs=16.7 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+.+....-.++ .=..|...+. T Consensus 193 ~~~~C~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 227 (414) T 4N6H_A 193 GELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVC 227 (414) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchhHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 356788777665544433333222 2234544444 No 402 >6AKX_B Neuropeptide Y receptor type 1,T4; G Protein-Coupled Receptor Chemokine Receptor; HET: A4R; 2.8A {Homo sapiens} Probab=41.42 E-value=3.8 Score=39.78 Aligned_cols=22 Identities=9% Similarity=0.150 Sum_probs=12.8 Template_Neff=12.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAA 665 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~ 665 (908) ....|.+..++..+++....-. T Consensus 99 ~~~~c~~~~~~~~~~~~~s~~~ 120 (381) T 6AKX_B 99 GNTMCQLLTGLYFIGFFSGIFF 120 (381) T ss_dssp CHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHH Confidence 3567887777665554443333 No 403 >6D9H_R Guanine nucleotide-binding protein G(i) subunit; signaling protein, membrane protein, active-state; HET: ADN;{Homo sapiens} Probab=40.77 E-value=3.9 Score=40.00 Aligned_cols=16 Identities=6% Similarity=-0.155 Sum_probs=9.4 Template_Neff=12.000 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+.+. T Consensus 132 ~~~C~~~~~~~~~~~~ 147 (389) T 6D9H_R 132 FHTCLMVACPVLILTQ 147 (389) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHH Confidence 4578777666554443 No 404 >6RZ4_A Cysteinyl leukotriene receptor 1,Soluble cytochrome; GPCR, LCP, MEMBRANE PROTEIN, cysteinyl; HET: KNT, OLC, OLA; 2.7A {Homo sapiens} Probab=39.89 E-value=4.1 Score=40.33 Aligned_cols=35 Identities=14% Similarity=0.081 Sum_probs=17.2 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if~ 678 (908) ....|.+..++..+......- .++.-.-|...+.+ T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~~ 130 (423) T 6RZ4_A 95 GDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVF 130 (423) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred cccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC Confidence 366788877665544333222 22333345444443 No 405 >6RZ5_B Cysteinyl leukotriene receptor 1,Soluble cytochrome; GPCR, LCP, MEMBRANE PROTEIN, cysteinyl; HET: 1PE, ZLK, OLA, OLC; 2.53A {Homo sapiens} Probab=39.89 E-value=4.1 Score=40.33 Aligned_cols=35 Identities=14% Similarity=0.081 Sum_probs=17.2 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if~ 678 (908) ....|.+..++..+......- .++.-.-|...+.+ T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~~ 130 (423) T 6RZ5_B 95 GDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVF 130 (423) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred cccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC Confidence 366788877665544333222 22333345444443 No 406 >5TVN_A 5-hydroxytryptamine receptor 2B,Soluble cytochrome b562,5-hydroxytryptamine; LSD, GPCR, serotonin receptor, MEMBRANE; HET: 7LD, OLC, CLR; 2.9A {Homo sapiens} Probab=39.86 E-value=4.1 Score=39.89 Aligned_cols=34 Identities=18% Similarity=0.015 Sum_probs=17.3 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..++.....-.+++= .-|...+. T Consensus 84 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 118 (402) T 5TVN_A 84 PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIK 118 (402) T ss_dssp CSTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CccchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887776655444333333332 23444443 No 407 >5UZ7_R Guanine nucleotide-binding protein G(s) subunit; Class B G protein-coupled receptor; 4.1A {Homo sapiens} Probab=39.51 E-value=4.3 Score=41.89 Aligned_cols=27 Identities=19% Similarity=0.292 Sum_probs=15.2 Template_Neff=10.000 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ...|.+..++..+.....+..+++-++ T Consensus 224 ~~~C~~~~~l~~~~~~~s~~wl~~iai 250 (501) T 5UZ7_R 224 PVSCKILHFFHQYMMACNYFWMLCEGI 250 (501) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 467887776665554444444444443 No 408 >6I9K_A Kumopsin1; Rhodopsin, GPCR, Light-sensitive, Retinal, MEMBRANE; HET: RET, OLC; 2.145A {Hasarius adansoni} Probab=38.98 E-value=4.4 Score=39.30 Aligned_cols=17 Identities=12% Similarity=0.123 Sum_probs=10.3 Template_Neff=12.400 Q NP_000836.2 645 TIICSFRRVFLGLGMCF 661 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l 661 (908) ...|.+..++..+++.. T Consensus 120 ~~~c~~~~~~~~~~~~~ 136 (380) T 6I9K_A 120 PFMCELYGMIGSLFGSA 136 (380) T ss_pred HHHHHHHHHHHHHHHHH Confidence 56787776665554433 No 409 >4XNV_A P2Y purinoceptor 1, Rubredoxin; human P2Y1 receptor, G protein; HET: CLR, BUR, 1PE, OLC, Y01; 2.2A {Homo sapiens} Probab=38.66 E-value=4.5 Score=40.04 Aligned_cols=33 Identities=15% Similarity=0.288 Sum_probs=16.8 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ...|.+..++..+++....-.+++- .-|...+. T Consensus 120 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 153 (421) T 4XNV_A 120 DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVV 153 (421) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 5678887776665544333333332 33444443 No 410 >4XNW_C P2Y purinoceptor 1, Rubredoxin; human P2Y1 receptor, G protein; HET: 2ID; 2.7A {Homo sapiens} Probab=38.66 E-value=4.5 Score=40.04 Aligned_cols=33 Identities=15% Similarity=0.288 Sum_probs=16.8 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ...|.+..++..+++....-.+++- .-|...+. T Consensus 120 ~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 153 (421) T 4XNW_C 120 DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVV 153 (421) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 5678887776665544333333332 33444443 No 411 >5WB1_A Envelope protein US28,nanobody 7; chemokine receptor, MEMBRANE PROTEIN; 3.508A {Human cytomegalovirus} Probab=38.12 E-value=4.6 Score=40.62 Aligned_cols=34 Identities=15% Similarity=0.208 Sum_probs=17.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++...+-.++.- .-|...+. T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 142 (458) T 5WB1_A 108 ASVPCTLLTACFYVAMFASLCFITEIALDRYYAIV 142 (458) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678877666555444433333332 33444443 No 412 >6LI1_A G-protein coupled receptor 52,Flavodoxin,G-protein coupled; Human GPR52 receptor, Class A; HET: PGE, OLC, FMN; 2.9A {Homo sapiens} Probab=38.11 E-value=4.6 Score=40.55 Aligned_cols=34 Identities=15% Similarity=0.199 Sum_probs=17.9 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ =.-|.+.+. T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 129 (449) T 6LI1_A 95 ESLTCQVFGYIISVLKSVSMWCLACISVDRYLAIT 129 (449) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4677888777665544433333333 334444444 No 413 >5UNG_B Soluble cytochrome b562,Type-2 angiotensin II; human Angiotensin II receptor complex; HET: OLC, OLA, 8ES; 2.8A {Escherichia coli} Probab=38.07 E-value=4.6 Score=39.71 Aligned_cols=33 Identities=21% Similarity=0.351 Sum_probs=17.1 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~i 676 (908) ....|.+..++..+++....-.++.- ..|...+ T Consensus 189 ~~~~c~~~~~~~~~~~~~s~~~~~~ia~~R~~~i 222 (411) T 5UNG_B 189 GPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSV 222 (411) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887776665554433333332 2344443 No 414 >5UNF_A Soluble cytochrome b562,Type-2 angiotensin II; human Angiotensin II receptor complex; HET: 8ES; 2.8A {Escherichia coli} Probab=37.89 E-value=4.7 Score=39.75 Aligned_cols=25 Identities=24% Similarity=0.344 Sum_probs=14.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+++....-.++. T Consensus 189 ~~~~c~~~~~~~~~~~~~s~~~~~~ 213 (411) T 5UNF_A 189 GPVMCKVFGSFLTLNMFASIFFITC 213 (411) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887777666555444333333 No 415 >6J21_A Substance-P receptor (E.C.3.2.1.17),Endolysin; GPCR, Complex, Antagonist, signalling protein; HET: GBQ, OLC; 3.2A {Homo sapiens} Probab=37.85 E-value=4.7 Score=40.12 Aligned_cols=34 Identities=18% Similarity=0.236 Sum_probs=16.7 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..++.....-.++ .=.-|...+. T Consensus 100 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 134 (441) T 6J21_A 100 GLFYCKFHNFFPIAAVFASIWSMTAVAFDRYMAII 134 (441) T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788877665544433332222 2334444443 No 416 >5ZHP_A Muscarinic acetylcholine receptor M3,Lysozyme,Muscarinic acetylcholine; G protein coupled receptor, MEMBRANE; HET: MAL, CIT, PG4, 9EC, P6G; 3.1A {Rattus norvegicus} Probab=37.68 E-value=4.7 Score=39.82 Aligned_cols=17 Identities=6% Similarity=0.079 Sum_probs=10.5 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+... T Consensus 81 ~~~~C~~~~~~~~~~~~ 97 (418) T 5ZHP_A 81 GNLACDLWLSIDYVASN 97 (418) T ss_dssp CHHHHHHHHHHHHHHHH T ss_pred cccHHHHHHHHHHHHHH Confidence 35678877776554443 No 417 >5NJ6_A Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated; MEMBRANE PROTEIN, GPCR, 7TM; 4.0A {Homo sapiens} Probab=37.61 E-value=4.7 Score=40.08 Aligned_cols=34 Identities=21% Similarity=0.221 Sum_probs=16.8 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+......-.+++ =.-|...+. T Consensus 91 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 125 (437) T 5NJ6_A 91 GEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIV 125 (437) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888776655544333333322 333444443 No 418 >5DSG_B Muscarinic acetylcholine receptor M4,Endolysin,Muscarinic acetylcholine; Membrane, GPCR, Signaling, Antagonist, MEMBRANE; HET: P6G, OLC, 0HK, PG6, EDT, OLA; 2.6A {Homo sapiens} Probab=37.28 E-value=4.8 Score=39.81 Aligned_cols=17 Identities=6% Similarity=0.130 Sum_probs=10.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+++. T Consensus 82 ~~~~C~~~~~~~~~~~~ 98 (422) T 5DSG_B 82 GAVVCDLWLALDYVVSN 98 (422) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHHH Confidence 36678877776554443 No 419 >4Z36_A Lysophosphatidic Acid Receptor 1, cytochrome; human lysophosphatidic acid receptor 1; HET: 1WV, ON3; 2.9A {Homo sapiens} Probab=37.22 E-value=4.9 Score=40.64 Aligned_cols=34 Identities=15% Similarity=0.156 Sum_probs=15.9 Template_Neff=11.200 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSY-AALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~-~~l~~K~~ri~~if~ 678 (908) ...|.+..++..+...... ..++.-.-|.+.+.+ T Consensus 136 ~~~c~~~~~l~~~~~~~s~~~l~~isidRy~aI~~ 170 (459) T 4Z36_A 136 VSTWLLRQGLIDTSLTASVANLLAIAIERHITVFR 170 (459) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHc Confidence 4578777666554333222 222233345544443 No 420 >6PT0_R Cannabinoid receptor 2, Guanine nucleotide-binding; GPCR complex, WIN55, 212-2, MEMBRANE; HET: WI5, CLR, PLM; 3.2A {Homo sapiens} Probab=36.97 E-value=4.9 Score=38.72 Aligned_cols=12 Identities=0% Similarity=-0.097 Sum_probs=5.9 Template_Neff=12.300 Q NP_000836.2 645 TIICSFRRVFLG 656 (908) Q Consensus 645 ~~~C~~~~~~~~ 656 (908) ...|....++.. T Consensus 103 ~~~~~~~~~~~~ 114 (369) T 6PT0_R 103 KAVFLLKIGSVT 114 (369) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 445655554443 No 421 >6OIJ_R Guanine nucleotide-binding protein G(i) subunit; G-protein coupled receptor-G-protein complex, neurotransmitter; HET: Y01, IXO; 3.3A {Homo sapiens} Probab=36.53 E-value=5.1 Score=38.43 Aligned_cols=34 Identities=18% Similarity=0.165 Sum_probs=16.6 Template_Neff=12.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+++....-.++. -.-|...+. T Consensus 103 ~~~~c~~~~~~~~~~~~~s~~~~~~i~~~R~~~i~ 137 (363) T 6OIJ_R 103 GTLACDLWLALDYVASQASVMNLLLISFDRYFSVT 137 (363) T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567877766655444433333322 233444444 No 422 >4Z35_A Lysophosphatidic Acid Receptor 1, cytochrome; human lysophosphatidic acid receptor 1; HET: ON9, 1WV; 2.9A {Homo sapiens} Probab=36.39 E-value=5.1 Score=40.54 Aligned_cols=14 Identities=7% Similarity=0.083 Sum_probs=8.0 Template_Neff=11.200 Q NP_000836.2 645 TIICSFRRVFLGLG 658 (908) Q Consensus 645 ~~~C~~~~~~~~~g 658 (908) ...|.+..++..++ T Consensus 136 ~~~c~~~~~l~~~~ 149 (464) T 4Z35_A 136 VSTWLLRQGLIDTS 149 (464) T ss_pred HHHHHHHHHHHHHH Confidence 45677666554443 No 423 >6KR8_A beta 2 adrenergic receptor; G-protein coupled receptor, b2AR, full; NMR {Homo sapiens} Probab=36.37 E-value=5.1 Score=37.80 Aligned_cols=34 Identities=21% Similarity=0.187 Sum_probs=16.9 Template_Neff=12.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+++....-.++ .-..|...+. T Consensus 79 ~~~~c~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 113 (336) T 6KR8_A 79 GNFWCEFWTSIDVLCVTASIWTLCVIAVDRYFAIC 113 (336) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCC T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 356788777766554433333222 2334444443 No 424 >6IIU_A Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane; GPCR, Complex, Antagonist, SIGNALING PROTEIN; HET: CLR, A8X, OLC; 2.5A {Escherichia coli} Probab=36.22 E-value=5.2 Score=40.63 Aligned_cols=24 Identities=4% Similarity=0.173 Sum_probs=11.7 Template_Neff=11.800 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVTFVRY 608 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~~~~~ 608 (908) ++..++.++|++..++.++.+... T Consensus 136 ~~~~~~~~lgi~~N~~~l~~~~~~ 159 (484) T 6IIU_A 136 WFAASFCVVGLASNLLALSVLAGA 159 (484) T ss_pred HHHHHHHHHHHHHHHHHHHHHHcc Confidence 444455555655554444444433 No 425 >6IIV_A Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane; GPCR, Complex, Antagonist, SIGNALING PROTEIN; HET: CLR, A90; 3.0A {Escherichia coli} Probab=36.22 E-value=5.2 Score=40.63 Aligned_cols=24 Identities=4% Similarity=0.173 Sum_probs=11.7 Template_Neff=11.800 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVTFVRY 608 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~~~~~ 608 (908) ++..++.++|++..++.++.+... T Consensus 136 ~~~~~~~~lgi~~N~~~l~~~~~~ 159 (484) T 6IIV_A 136 WFAASFCVVGLASNLLALSVLAGA 159 (484) T ss_pred HHHHHHHHHHHHHHHHHHHHHHcc Confidence 444455555655554444444433 No 426 >6E3Y_R Calcitonin gene-related peptide 1, Nanobody; class B G protein-coupled receptor; 3.3A {Lama glama} Probab=36.12 E-value=5.2 Score=41.00 Aligned_cols=25 Identities=16% Similarity=0.236 Sum_probs=13.8 Template_Neff=10.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+.....+.-+++ T Consensus 218 ~~~~C~~~~~l~~~~~~as~~wl~~ 242 (490) T 6E3Y_R 218 NPVSCKVSQFIHLYLMGCNYFWMLC 242 (490) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHH Confidence 3577887776655544443333333 No 427 >6UUN_R Guanine nucleotide-binding protein G(s) subunit; GPCR, adrenomedullin receptor complex, MEMBRANE;{Homo sapiens} Probab=36.12 E-value=5.2 Score=41.00 Aligned_cols=25 Identities=16% Similarity=0.236 Sum_probs=13.8 Template_Neff=10.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT 668 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~ 668 (908) ....|.+..++..+.....+.-+++ T Consensus 218 ~~~~C~~~~~l~~~~~~as~~wl~~ 242 (490) T 6UUN_R 218 NPVSCKVSQFIHLYLMGCNYFWMLC 242 (490) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHH Confidence 3577887776655544443333333 No 428 >6M1I_A Ribonuclease 3 (E.C.3.1.26.3), Microprocessor complex; GPCR, PROTEIN BINDING; 3.5A {Homo sapiens} Probab=35.51 E-value=5.4 Score=39.54 Aligned_cols=28 Identities=21% Similarity=0.265 Sum_probs=17.2 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ....|.+..++..++....+..+++-++ T Consensus 184 ~~~~C~~~~~~~~~~~~~s~~~l~~ia~ 211 (406) T 6M1I_A 184 STVECKAVMVFFHYCVVSNYFWLFIEGL 211 (406) T ss_dssp CCSHHHHHHHHHHHHHHTTTTTTHHHHH T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3578888877766655555555554443 No 429 >4XT1_A US28, CX3CL1, nanobody 7; GPCR, chemokine, membrane protein, complex; HET: CLR, UNL, OLC; 2.886A {Cytomegalovirus} Probab=35.42 E-value=5.4 Score=38.30 Aligned_cols=35 Identities=14% Similarity=0.192 Sum_probs=17.1 Template_Neff=12.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if~ 678 (908) ....|.+..++...++....-.++. -.-|...+.+ T Consensus 108 ~~~~C~~~~~~~~~~~~~s~~~~~~i~~~R~~~i~~ 143 (362) T 4XT1_A 108 ASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVY 143 (362) T ss_dssp -CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTS T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHc Confidence 3567877766655444433333332 3345444443 No 430 >6LW5_A N-formyl peptide receptor 2,Soluble cytochrome; Formyl peptide receptor, G protein-coupled; HET: CLR; 2.8A {Escherichia coli} Probab=35.22 E-value=5.5 Score=39.58 Aligned_cols=18 Identities=11% Similarity=0.361 Sum_probs=10.6 Template_Neff=11.700 Q NP_000836.2 645 TIICSFRRVFLGLGMCFS 662 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~ 662 (908) ...|.+..++..+++... T Consensus 200 ~~~C~~~~~~~~~~~~~s 217 (427) T 6LW5_A 200 WFLCKLIHIVVDINLFGS 217 (427) T ss_dssp HHHHHHHHHHHHHHHHHH T ss_pred ccHHHHHHHHHHHHHHHH Confidence 456877776655444433 No 431 >5VBL_B agonist peptide,Rubredoxin-Apelin receptor chimera; human apelin receptor complex, agonist; HET: ALC, OLC, 200, HRG, OIC; 2.6A {Homo sapiens} Probab=34.87 E-value=5.6 Score=39.04 Aligned_cols=34 Identities=21% Similarity=0.230 Sum_probs=17.0 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+.+....-.++.- .-|...+. T Consensus 116 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 150 (407) T 5VBL_B 116 GTFFCKLSSYLIFVNMYASAFCLTGLSFDRYLAIV 150 (407) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35678887766655444333333332 33444443 No 432 >5V54_B OB-1 fused 5-HT1b receptor; 5-hydroxytryptamine, GPCR antagonist, OB1, ELECTRON; HET: 89F; 3.9A {Homo sapiens} Probab=34.66 E-value=5.7 Score=38.71 Aligned_cols=34 Identities=18% Similarity=0.068 Sum_probs=16.9 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ =.-|...+. T Consensus 82 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 116 (395) T 5V54_B 82 GQVVCDFWLSSDITCCTASIWHLCVIALDRYWAIT 116 (395) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTT T ss_pred chhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777655444333333333 233444443 No 433 >5WB2_A Envelope protein US28,nanobody 7, CX3CL1; chemokine receptor, engineered proteins, MEMBRANE; HET: YCM, MES, CLR, OLC; 3.5A {Human cytomegalovirus} Probab=34.21 E-value=5.8 Score=39.81 Aligned_cols=34 Identities=15% Similarity=0.208 Sum_probs=17.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++....-.++.- .-|...+. T Consensus 107 ~~~~C~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 141 (460) T 5WB2_A 107 ASVPCTLLTACFYVAMFASLCFITEIALDRYYAIV 141 (460) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred cchHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHH Confidence 35678877766655444333333332 33444443 No 434 >6IBB_A Succinate receptor 1, Nanobody6; SUCNR1 GPR91 GPCR G-Protein coupled; HET: GOL, OLC, CLR, H95; 2.12A {Rattus norvegicus} Probab=33.17 E-value=6.2 Score=37.34 Aligned_cols=34 Identities=18% Similarity=0.179 Sum_probs=17.1 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++....+....-.++. -..|...+. T Consensus 94 ~~~~c~~~~~~~~~~~~~s~~~~~~ia~~R~~~i~ 128 (342) T 6IBB_A 94 GDVLCISNRYVLHANLYTSILFLTFISIDRYLLMK 128 (342) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887776665544333333333 234444443 No 435 >4GBR_A Beta-2 adrenergic receptor, Lysozyme (E.C.3.2.1.17); 7 transmembrane helices, G-protein coupled; HET: CAU; 3.993A {Homo sapiens} Probab=32.99 E-value=6.3 Score=36.36 Aligned_cols=17 Identities=18% Similarity=0.247 Sum_probs=10.3 Template_Neff=12.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|....++...+.. T Consensus 74 ~~~~c~~~~~~~~~~~~ 90 (309) T 4GBR_A 74 GNFWCEFWTSIDVLCVT 90 (309) T ss_pred chhHHHHHHHHHHHHHH Confidence 35678777766554443 No 436 >6NBF_R Parathyroid hormone/parathyroid hormone-related peptide receptor; Parathyroid hormone receptor, GPCR, Class; HET: CLR, PLM; 3.0A {Homo sapiens} Probab=32.16 E-value=6.7 Score=40.00 Aligned_cols=29 Identities=17% Similarity=0.206 Sum_probs=17.2 Template_Neff=9.800 Q NP_000836.2 646 IICSFRRVFLGLGMCFSYAALLTKTNRIH 674 (908) Q Consensus 646 ~~C~~~~~~~~~gf~l~~~~l~~K~~ri~ 674 (908) ..|.+...+...+....+.-+++-.+-.| T Consensus 253 ~~C~~~~~l~~~~~~~s~~wl~~~al~~~ 281 (478) T 6NBF_R 253 AGCRVAVTFFLYFLATNYYWILVEGLYLH 281 (478) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 67888777766665555555555444333 No 437 >6NBH_R Parathyroid hormone/parathyroid hormone-related peptide receptor; Parathyroid hormone receptor, GPCR, Class; HET: CLR, PLM; 3.5A {Homo sapiens} Probab=32.16 E-value=6.7 Score=40.00 Aligned_cols=29 Identities=17% Similarity=0.206 Sum_probs=17.2 Template_Neff=9.800 Q NP_000836.2 646 IICSFRRVFLGLGMCFSYAALLTKTNRIH 674 (908) Q Consensus 646 ~~C~~~~~~~~~gf~l~~~~l~~K~~ri~ 674 (908) ..|.+...+...+....+.-+++-.+-.| T Consensus 253 ~~C~~~~~l~~~~~~~s~~wl~~~al~~~ 281 (478) T 6NBH_R 253 AGCRVAVTFFLYFLATNYYWILVEGLYLH 281 (478) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 67888777766665555555555444333 No 438 >6LML_R Guanine nucleotide-binding protein G(i) subunit; glucagon receptor, GPCR, Gi1 protein;{Homo sapiens} Probab=31.93 E-value=6.8 Score=39.09 Aligned_cols=34 Identities=24% Similarity=0.451 Sum_probs=22.0 Template_Neff=10.300 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ...|.+..++........+.-+++-.+-+++.+. T Consensus 195 ~~~C~~~~~~~~~~~~~s~~w~~~~~~~l~~~i~ 228 (422) T 6LML_R 195 VAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG 228 (422) T ss_dssp CTHHHHHHHHHHHHTTTTTTHHHHHHHHHHHHTT T ss_pred hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4788888777776666666666665555555443 No 439 >6WHC_R Guanine nucleotide-binding protein G(s) subunit; GPCR, receptor complex, MEMBRANE PROTEIN;{Homo sapiens} Probab=31.83 E-value=6.8 Score=39.91 Aligned_cols=34 Identities=24% Similarity=0.451 Sum_probs=22.5 Template_Neff=9.900 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ...|.+..++........+.-+++-.+-+|+... T Consensus 221 ~~~C~~~~~~~~~~~~~s~~wl~~~~l~l~~~i~ 254 (477) T 6WHC_R 221 VAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG 254 (477) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3688888877777666666666666655555443 No 440 >6LI2_A G-protein coupled receptor 52,Rubredoxin,G-protein coupled; Human GPR52 receptor, Class A; HET: OLC; 2.8A {Homo sapiens} Probab=31.69 E-value=6.8 Score=37.61 Aligned_cols=34 Identities=15% Similarity=0.199 Sum_probs=17.6 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.++. =.-|...+. T Consensus 95 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 129 (372) T 6LI2_A 95 ESLTCQVFGYIISVLKSVSMWCLACISVDRYLAIT 129 (372) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 3567888777766544433333333 334444444 No 441 >4L6R_A Soluble cytochrome b562 and Glucagon; Human glucagon receptor, diabetes, GPCR; 3.3A {Escherichia coli, Homo sapiens} Probab=31.23 E-value=7.1 Score=38.95 Aligned_cols=34 Identities=24% Similarity=0.451 Sum_probs=21.3 Template_Neff=10.500 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ...|.+..++..++....+.-+++-.+-++..+. T Consensus 205 ~~~C~~~~~~~~~~~las~~w~~~i~~~~~~~~~ 238 (425) T 4L6R_A 205 VAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG 238 (425) T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 5678887777766665555555555555555444 No 442 >6KUW_A Alpha-2C adrenergic receptor; Alpha2c adrenergic receptor, antagonist, GPCR; HET: OLC, OLA, CLR, E33; 2.8A {Homo sapiens} Probab=31.07 E-value=7.1 Score=39.70 Aligned_cols=17 Identities=12% Similarity=-0.062 Sum_probs=10.6 Template_Neff=11.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+... T Consensus 92 ~~~~C~~~~~~~~~~~~ 108 (496) T 6KUW_A 92 GQWWCGVYLALDVLFCT 108 (496) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHH Confidence 36678887776554443 No 443 >4WW3_A BOG; Animals, Decapodiformes, Inositol 1, 4; HET: TWT, PC1, PLM, BOG, RET; 2.8A {Todarodes pacificus} Probab=30.81 E-value=7.2 Score=36.86 Aligned_cols=17 Identities=12% Similarity=0.038 Sum_probs=10.5 Template_Neff=12.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..++.. T Consensus 96 ~~~~c~~~~~~~~~~~~ 112 (350) T 4WW3_A 96 GFAACKVYGFIGGIFGF 112 (350) T ss_dssp HHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHH Confidence 35678777766554443 No 444 >6J20_A Substance-P receptor,Endolysin (E.C. 3.2.1.17); GPCR, Complex, Antagonist, signalling protein; HET: GBQ; 2.7A {Homo sapiens} Probab=30.61 E-value=7.3 Score=38.58 Aligned_cols=34 Identities=18% Similarity=0.236 Sum_probs=17.0 Template_Neff=12.300 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALL-TKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~-~K~~ri~~if 677 (908) ....|.+..++..+......-.++ .=.-|...+. T Consensus 100 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~Ry~~i~ 134 (441) T 6J20_A 100 GLFYCKFHNFFPIAAVFASIWSMTAVAFDRYMAII 134 (441) T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 356788877766544433333322 2334444444 No 445 >5YWY_A Prostaglandin E2 receptor EP4 subtype; G-protein coupled receptor, lipid mediator; HET: 7UR; 3.2A {Homo sapiens} Probab=30.60 E-value=7.3 Score=36.50 Aligned_cols=34 Identities=12% Similarity=0.138 Sum_probs=16.9 Template_Neff=12.600 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..+.+....-.++. -.-|...+. T Consensus 88 ~~~~c~~~~~~~~~~~~~s~~~~~~is~~R~~~i~ 122 (332) T 5YWY_A 88 GQPLCEYSTFILLFFSLSRLSIICAMSVERYLAIN 122 (332) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888776665544433333322 233444443 No 446 >4JKV_A Soluble cytochrome b562, Smoothened homolog; Human smoothened receptor, antitumor agent; HET: 1KS, PG4, PGE, OLA, PEG, OLC; 2.45A {Escherichia coli} Probab=30.35 E-value=7.5 Score=39.54 Aligned_cols=34 Identities=18% Similarity=0.213 Sum_probs=19.3 Template_Neff=9.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++..+++...+.-+++-++-++..+ T Consensus 230 ~~~~C~~~~~l~~~~~las~~w~~~~a~~~~~~i 263 (475) T 4JKV_A 230 ETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF 263 (475) T ss_dssp SCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887777766665555554444444444433 No 447 >4N4W_A Smoothened homolog; Human smoothened receptor, antitumor agent; HET: MAN, BMA, SNT, PG4, NAG, OLC; 2.8A {Homo sapiens, Shigella flexneri} Probab=30.35 E-value=7.5 Score=39.54 Aligned_cols=34 Identities=18% Similarity=0.213 Sum_probs=19.3 Template_Neff=9.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) ....|.+..++..+++...+.-+++-++-++..+ T Consensus 230 ~~~~C~~~~~l~~~~~las~~w~~~~a~~~~~~i 263 (475) T 4N4W_A 230 ETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSF 263 (475) T ss_dssp SCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGG T ss_pred CchhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567887777766665555554444444444433 No 448 >6FJ3_A Parathyroid hormone/parathyroid hormone-related peptide receptor; GPCR, cell signalling, 7TM, MEMBRANE; HET: FUC, OLA, NAG, MAN, YCM, PG4, HRG, BMA; 2.5A {Homo sapiens} Probab=30.23 E-value=7.5 Score=41.02 Aligned_cols=33 Identities=12% Similarity=0.126 Sum_probs=21.0 Template_Neff=10.000 Q NP_000836.2 646 IICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 646 ~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ..|.+..+++...+...|.=+++-.+-+|+.+. T Consensus 214 ~~C~~~~~~~~y~~la~~~Wm~~e~~~l~~~i~ 246 (602) T 6FJ3_A 214 AGCRVAVTFFLYFLATNYYWIAVEGLYLHSLIF 246 (602) T ss_dssp -HHH-HHHH--HHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 678888888777777777777777766666544 No 449 >5ZBH_A Neuropeptide Y receptor type 1,T4; G Protein-Coupled Receptor Neuropeptide Y; HET: 9AF; 3.0A {Homo sapiens} Probab=29.80 E-value=7.7 Score=39.78 Aligned_cols=17 Identities=6% Similarity=0.305 Sum_probs=10.6 Template_Neff=11.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+.+. T Consensus 118 ~~~~C~~~~~~~~~~~~ 134 (527) T 5ZBH_A 118 GEAMCKLNPFVQCVSIT 134 (527) T ss_pred hHHHHHHHHHHHHHHHH Confidence 35678887766554443 No 450 >6NIY_R Adenosine receptor A1,Soluble cytochrome b562,Adenosine; GPCR, transmembrane, receptor, calcitonin, MEMBRANE;{Homo sapiens} Probab=29.59 E-value=7.9 Score=39.32 Aligned_cols=27 Identities=19% Similarity=0.292 Sum_probs=15.1 Template_Neff=10.300 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ...|.+..++..+.....+.-+++-++ T Consensus 216 ~~~C~~~~~l~~~~~~~s~~w~~~ia~ 242 (474) T 6NIY_R 216 PVSCKILHFFHQYMMACNYFWMLCEGI 242 (474) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 567887776665554444444444443 No 451 >5XJM_A Type-2 angiotensin II receptor,Soluble cytochrome; class A GPCR, regulate human; 3.2A {Mus musculus} Probab=29.03 E-value=8.1 Score=37.87 Aligned_cols=34 Identities=21% Similarity=0.365 Sum_probs=17.6 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++..++.....-.+++ -.-|...+. T Consensus 80 ~~~~C~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 114 (422) T 5XJM_A 80 GPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVI 114 (422) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888877766554433333332 233444443 No 452 >6VMS_R Guanine nucleotide-binding protein G(i) subunit; Dopamine, Dopamine receptor, GPCR, G; HET: 08Y; 3.8A {Rattus norvegicus} Probab=28.87 E-value=8.2 Score=38.63 Aligned_cols=16 Identities=13% Similarity=0.044 Sum_probs=9.8 Template_Neff=11.300 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+++. T Consensus 245 ~~~C~~~~~~~~~~~~ 260 (450) T 6VMS_R 245 RIHCDIFVTLDVMMCT 260 (450) T ss_dssp TTHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHH Confidence 5678777766554443 No 453 >6PS2_A Fusion protein of Beta-2 adrenergic; GPCR, COMPLEX-LCP method, SBDD, drug; HET: CLR, SO4, JTZ, OLB, OLA, OLC; 2.4A {Homo sapiens} Probab=28.33 E-value=8.5 Score=39.39 Aligned_cols=34 Identities=18% Similarity=0.134 Sum_probs=16.6 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYA-ALLTKTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~-~l~~K~~ri~~if 677 (908) ....|.+..++..++.....- .++.=.-|.+.+. T Consensus 126 ~~~~C~~~~~l~~~~~~~s~~~~~~iai~Ry~ai~ 160 (506) T 6PS2_A 126 GNFWCEFWTSIDVLCVTASIWTLCVIAVDRYFAIT 160 (506) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 356788777765544433222 2233334544443 No 454 >6PB0_R Corticotropin-releasing factor receptor 1, Urocortin; Corticotropin-releasing factor 1 receptor, urocortins1; HET: CLR, PLM; 3.0A {Homo sapiens} Probab=28.25 E-value=8.6 Score=37.30 Aligned_cols=28 Identities=4% Similarity=-0.014 Sum_probs=17.0 Template_Neff=11.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTN 671 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ 671 (908) ....|.+..++...+....+..+++-.+ T Consensus 161 ~~~~C~~~~~~~~~~~~~s~~~l~~ia~ 188 (375) T 6PB0_R 161 NVGWCRLVTAAYNYFHVTNFFWMFGEGC 188 (375) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3567888777766655555555555443 No 455 >3PDS_A Fusion protein Beta-2 adrenergic receptor/Lysozyme; GPCR, signaling, beta adrenergic agonist; HET: ERC, CLR, SO4; 3.5A {Homo sapiens,Enterobacteria phage T4,Homo sapiens} Probab=28.08 E-value=8.7 Score=38.53 Aligned_cols=33 Identities=15% Similarity=0.119 Sum_probs=16.1 Template_Neff=11.400 Q NP_000836.2 645 TIICSFRRVFLGLGMCF-SYAALLTKTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l-~~~~l~~K~~ri~~if 677 (908) ...|.+..++..++... .+..++.=.-|.+.+. T Consensus 79 ~~~c~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 112 (458) T 3PDS_A 79 NFWCEFWTSIDVLCVTASIETLCVIAVDRYFAIT 112 (458) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 56787777665544332 2223333334544443 No 456 >5UEN_B Adenosine receptor A1,Soluble cytochrome b562,Adenosine; GPCR, transmembrane, receptor, adenosine, MEMBRANE; HET: OLA, DU1; 3.2A {Homo sapiens} Probab=27.53 E-value=9 Score=37.51 Aligned_cols=16 Identities=6% Similarity=-0.155 Sum_probs=9.6 Template_Neff=12.200 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+.+. T Consensus 78 ~~~C~~~~~~~~~~~~ 93 (416) T 5UEN_B 78 FHTCLMVACPVLILTQ 93 (416) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred cchhHHHHHHHHHHHH Confidence 4578777766554443 No 457 >5ZBQ_A Neuropeptide Y Y1 receptor in; G Protein-Coupled Receptor, Receptor Inhibitor; HET: 9AO; 2.7A {Homo sapiens} Probab=27.31 E-value=9.1 Score=39.21 Aligned_cols=20 Identities=10% Similarity=0.287 Sum_probs=11.7 Template_Neff=11.500 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSY 663 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~ 663 (908) ....|.+..++..+++.... T Consensus 108 ~~~~C~~~~~~~~~~~~~s~ 127 (525) T 5ZBQ_A 108 GEAMCKLNPFVQCVSITVSI 127 (525) T ss_pred hHHHHHHHHHHHHHHHHHHH Confidence 35678877766655544333 No 458 >6RNK_A Succinate receptor 1, Nanobody6; SUCNR1, GPR91, GPCR, G-Protein coupled; HET: KAZ, OLC; 1.94A {Rattus norvegicus} Probab=27.26 E-value=9.1 Score=36.04 Aligned_cols=34 Identities=18% Similarity=0.179 Sum_probs=16.7 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLT-KTNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~-K~~ri~~if 677 (908) ....|.+..++...++....-.++. -.-|...+. T Consensus 94 ~~~~c~~~~~~~~~~~~~s~~~~~~i~~~R~~~i~ 128 (342) T 6RNK_A 94 GDVLCISNRYVLHANLYTSILFLTFISIDRYLLMK 128 (342) T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 3567877776665544433333332 233444443 No 459 >5UEN_A Adenosine receptor A1,Soluble cytochrome b562,Adenosine; GPCR, transmembrane, receptor, adenosine, MEMBRANE; HET: DU1, OLA; 3.2A {Homo sapiens} Probab=27.12 E-value=9.2 Score=37.37 Aligned_cols=16 Identities=6% Similarity=-0.155 Sum_probs=9.6 Template_Neff=12.300 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..++.. T Consensus 78 ~~~C~~~~~~~~~~~~ 93 (416) T 5UEN_A 78 FHTCLMVACPVLILTQ 93 (416) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred cchhHHHHHHHHHHHH Confidence 4578777766554443 No 460 >6PB1_P Corticotropin-releasing factor receptor 2, Urocortin; Corticotropin-releasing factor 2 receptor, urocortins1; HET: CLR, PLM; 2.8A {Homo sapiens} Probab=26.87 E-value=9.4 Score=37.30 Aligned_cols=33 Identities=6% Similarity=0.185 Sum_probs=20.5 Template_Neff=10.700 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRI 676 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~i 676 (908) ....|.+..++...+....+..+++-.+-.|.. T Consensus 179 ~~~~C~~~~~~~~~~~~~s~~~l~~ia~~ry~~ 211 (387) T 6PB1_P 179 NEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTA 211 (387) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 457888887777666665555555555444433 No 461 >6OMM_R N-formyl peptide receptor 2, Peptide; Formyl peptide receptor 2/lipoxin A4; HET: PLM, CLR; 3.17A {Homo sapiens} Probab=26.55 E-value=9.6 Score=36.23 Aligned_cols=16 Identities=6% Similarity=0.468 Sum_probs=9.9 Template_Neff=12.500 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++..+++. T Consensus 116 ~~~c~~~~~~~~~~~~ 131 (363) T 6OMM_R 116 WFLCKLIHIVVDINLF 131 (363) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHH Confidence 5678777666554443 No 462 >5N2S_A Adenosine receptor A2a,Soluble cytochrome b562,Adenosine; G-PROTEIN-COUPLED RECEPTOR, INTEGRAL THERMOSTABILIZING MUTATIONS; HET: 8K8, SO4; 3.303A {Escherichia coli} Probab=26.30 E-value=9.8 Score=37.63 Aligned_cols=15 Identities=7% Similarity=-0.115 Sum_probs=8.7 Template_Neff=11.900 Q NP_000836.2 645 TIICSFRRVFLGLGM 659 (908) Q Consensus 645 ~~~C~~~~~~~~~gf 659 (908) ...|.+..++..+.+ T Consensus 184 ~~~c~~~~~~~~~~~ 198 (436) T 5N2S_A 184 FHTCLMVACPVLILA 198 (436) T ss_dssp HHHHHHHHHHHHHHH T ss_pred hHHHHHhHHHHHHHH Confidence 446777666655433 No 463 >5LWE_A C-C chemokine receptor type 9; Membrane protein; HET: CLR, 79K, MLI, OLA; 2.8A {Homo sapiens} Probab=25.09 E-value=11 Score=35.31 Aligned_cols=20 Identities=10% Similarity=0.283 Sum_probs=11.5 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSY 663 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~ 663 (908) ....|....++..+++.... T Consensus 93 ~~~~c~~~~~~~~~~~~~s~ 112 (331) T 5LWE_A 93 QTFMCKVVNSMYKMNFYSCV 112 (331) T ss_dssp -CHHHHHHHHHHHHHHHHHH T ss_pred chHHHHHHHHHHHHHHHHHH Confidence 46678877766555444333 No 464 >5ZTY_A G protein coupled receptor, T4; GPCR, cell signaling, ligand design; HET: OLC, SO4, PG4, OLA, 9JU, PEG, EPE; 2.8A {Homo sapiens} Probab=24.40 E-value=11 Score=38.32 Aligned_cols=20 Identities=15% Similarity=0.295 Sum_probs=9.0 Template_Neff=10.800 Q NP_000836.2 585 VVPVFVAILGIIATTFVIVT 604 (908) Q Consensus 585 ~~~~~~~~~~i~~~~~~~~~ 604 (908) ++..++.++|++.-+++++. T Consensus 37 ~~~~i~~~~gl~gN~lvl~~ 56 (500) T 5ZTY_A 37 VLCTLLGLLSALENVAVLYL 56 (500) T ss_pred HHHHHHHHHHHHHHHHHHHH Confidence 33444445555444444433 No 465 >2KSA_A Substance-P receptor, Substance P; Substance P, DMPC/CHAPS bicelle, Autodock; NMR {Homo sapiens} Probab=23.57 E-value=12 Score=35.48 Aligned_cols=16 Identities=19% Similarity=0.395 Sum_probs=9.5 Template_Neff=12.600 Q NP_000836.2 645 TIICSFRRVFLGLGMC 660 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~ 660 (908) ...|.+..++...++. T Consensus 102 ~~~c~~~~~~~~~~~~ 117 (364) T 2KSA_A 102 LFYCKFHNFFPIAAVF 117 (364) T ss_dssp HHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHH Confidence 5677776666554443 No 466 >5LWE_B C-C chemokine receptor type 9; Membrane protein; HET: 79K, OLA, MLI, CLR; 2.8A {Homo sapiens} Probab=23.45 E-value=12 Score=34.90 Aligned_cols=18 Identities=11% Similarity=0.333 Sum_probs=10.4 Template_Neff=12.400 Q NP_000836.2 644 DTIICSFRRVFLGLGMCF 661 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l 661 (908) ....|.+..++..+++.. T Consensus 93 ~~~~c~~~~~~~~~~~~~ 110 (331) T 5LWE_B 93 QTFMCKVVNSMYKMNFYS 110 (331) T ss_dssp -CTTHHHHHHHHHHHHHH T ss_pred chhHHHHHHHHHHHHHHH Confidence 456787776665544443 No 467 >5DHG_B Nociceptin receptor-Cytochrome b562 Chimera; Nociceptin/orphanin FQ peptide receptor, NOP; HET: DGV, OLA, OLC; 3.0A {Escherichia coli} Probab=23.42 E-value=12 Score=36.65 Aligned_cols=34 Identities=18% Similarity=0.097 Sum_probs=17.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++...+-.++.- ..|...+. T Consensus 193 ~~~~c~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 227 (424) T 5DHG_B 193 GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIC 227 (424) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 35678877776655544433333332 33444443 No 468 >5DHH_B GPCR-BRIL Chimera; Nociceptin/orphanin FQ peptide receptor, NOP; HET: OLA, OLC, DGW; 3.004A {Homo sapiens} Probab=23.42 E-value=12 Score=36.65 Aligned_cols=34 Identities=18% Similarity=0.097 Sum_probs=17.4 Template_Neff=12.100 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTK-TNRIHRIF 677 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K-~~ri~~if 677 (908) ....|.+..++..+++...+-.++.- ..|...+. T Consensus 193 ~~~~c~~~~~~~~~~~~~s~~~~~~iai~R~~~i~ 227 (424) T 5DHH_B 193 GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAIC 227 (424) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 35678877776655544433333332 33444443 No 469 >4DKL_A Mu-type opioid receptor, lysozyme chimera; G-protein coupled receptor, 7 transmembrane; HET: SO4, CLR, MPG, BF0, 1PE; 2.8A {Mus musculus, Enterobacteria phage T4} Probab=20.35 E-value=15 Score=36.47 Aligned_cols=17 Identities=18% Similarity=0.227 Sum_probs=10.1 Template_Neff=11.900 Q NP_000836.2 644 DTIICSFRRVFLGLGMC 660 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~ 660 (908) ....|.+..++..+++. T Consensus 85 ~~~~C~~~~~~~~~~~~ 101 (464) T 4DKL_A 85 GNILCKIVISIDYYNMF 101 (464) T ss_dssp CSHHHHHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHH Confidence 35678777766554433 No 470 >5NX2_A Glucagon-like peptide 1 receptor, truncated; 7TM, GPCR, signalling protein, membrane; HET: SOG, 9DQ, 9DZ, 9DT, 9DW, 9DK, NAG; 3.7A {Homo sapiens} Probab=20.13 E-value=16 Score=36.14 Aligned_cols=33 Identities=15% Similarity=0.316 Sum_probs=19.8 Template_Neff=10.600 Q NP_000836.2 645 TIICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 677 (908) Q Consensus 645 ~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if 677 (908) +..|.+..++........+.-+++-.+-+++.. T Consensus 204 ~~~C~~~~~~~~~~~las~~w~~~~~~~~~~~i 236 (422) T 5NX2_A 204 SLSCRLVFLFMQYCVAANYYWLLVEGVYLYTLL 236 (422) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 478888777766665555555555554444443 No 471 >6LN2_A Glucagon-like peptide 1 receptor,Rubredoxin,Glucagon-like peptide; Full length Human GLP1 receptor; HET: 97Y, NAG; 3.2A {Homo sapiens} Probab=20.07 E-value=16 Score=36.87 Aligned_cols=35 Identities=14% Similarity=0.264 Sum_probs=21.7 Template_Neff=8.200 Q NP_000836.2 644 DTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFE 678 (908) Q Consensus 644 ~~~~C~~~~~~~~~gf~l~~~~l~~K~~ri~~if~ 678 (908) ....|.+..++....+...+.-+++-.+-+++.+. T Consensus 199 ~~~~C~~~~~l~~y~~las~~W~~~~a~~l~~~i~ 233 (469) T 6LN2_A 199 DSLACRLVFLLCQYCVAANYYWLLVEGVYLYTLLA 233 (469) T ss_dssp HHTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 35778888777766666666666555555444443